The central nervous system and infection by Candida species.
In this paper we have reviewed the main clinico-pathologic disease groups of neurocandidiasis: the microabscesses, the macroabscesses, and the meningitis. Special attention has been paid to the predisposing conditions for the appearance of neurocandidiasis, the neuroimaging techniques, and the study of the cerebrospinal fluid, needed for diagnosis. We have also discussed the differential diagnosis with other illnesses. Treatment should be given with amphotericin-B and 5-fluorocytosine. The use of other antifungal drugs for neurocandidiasis is also discussed.
Sánchez-Portocarrero
J
J
Department of Medicine, European University of Madrid, Villaviciosa De Odón, 28670, Madrid, Spain. jorge.sanchez@ema.cisa.uem.es
Pérez-Cecilia
E
E
Corral
O
O
Romero-Vivas
J
J
Picazo
J J
JJ
D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D002175:Candida; D002176:Candida albicans; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D020314:Central Nervous System Fungal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D006801:Humans; D007165:Immunosuppression Therapy; D016921:Meningitis, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D012307:Risk Factors; D015819:Substance Abuse, Intravenous / Q000150:complications