Interleukin 6 may be an important mediator of trimethoprim-induced systemic adverse reaction resembling aseptic meningitis.
Antonen
J
J
Hulkkonen
J
J
Pasternack
A
A
Hurme
M
M
D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D016207:Cytokines / Q000097:blood* / Q000134:cerebrospinal fluid*; D006261:Headache / Q000139:chemically induced; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis* / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D008582:Meningitis, Aseptic / Q000097:blood / Q000134:cerebrospinal fluid / Q000139:chemically induced*; D009127:Muscle Rigidity / Q000139:chemically induced; D020795:Photophobia / Q000139:chemically induced; D014295:Trimethoprim / Q000009:adverse effects*
D000892:Anti-Infective Agents, Urinary; D016207:Cytokines; D015850:Interleukin-6; D014295:Trimethoprim