Fatal invasive aspergillosis complicating severe Plasmodium falciparum malaria.
We report the first 2 cases of fatal invasive aspergillosis complicating severe malaria. In 2 nonimmune European adults without underlying disease, death was directly ascribable to invasive aspergillosis. We believe that transient malaria-induced immunosuppression allowed massive growth and overwhelming dissemination of preexisting Aspergillus colonization.
Hocqueloux
L
L
Clinique de Réanimation des Maladies Infectieuses, Hôpital Bichat-Claude Bernard, 75018 Paris, France.
Bruneel
F
F
Pages
C L
CL
Vachon
F
F
D000328:Adult; D001228:Aspergillosis / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology; D001230:Aspergillus / Q000302:isolation & purification; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D017809:Fatal Outcome; D006801:Humans; D016778:Malaria, Falciparum / Q000150:complications*; D008297:Male