The effect of propofol and alfentanil on the increase in intraocular pressure due to succinylcholine and intubation.
OBJECTIVE
The aim of this study was to evaluate the effects of propofol and alfentanil on the increase in intraocular pressure (IOP) due to succinylcholine and intubation, in comparison with thiopental sodium and vecuronium bromide.


METHODS
Forty patients aged 20-50 years, scheduled for elective surgery requiring endotracheal intubation, were assigned to four groups of ten. General anesthesia was induced with 2.5 mg/kg propofol in Group I, 2.5 mg/kg propofol and 10 microg/kg alfentanil in Group II and 5 mg/kg thiopental in Groups III and IV; muscle relaxation was obtained with either 1.5 mg/kg succinylcholine (Group I, II and III) or 0.1 mg/kg vecuronium bromide (Group IV). In all patients mean arterial pressure, heart rate, oxygen saturation and IOP were recorded before (baseline) and after induction, after the muscle relaxant and after endotracheal intubation.


RESULTS
Compared with their baseline values in Group I IOP decreased significantly after propofol (p<0.01) and increased significantly after intubation (p<0.01). In Group II IOP decreased significantly after propofol and alfentanyl (p<0.001), remained low after succinylcholine (p<0.01) and did not change after intubation. In Group III IOP decreased significantly after thiopental (p<0.001) and increased significantly after intubation (p<0.001). In Group IV it decreased significantly after thiopental (p<0.001), remained low after vecuronium (p<0.001) and increased significantly after intubation (p<0.05).


CONCLUSIONS
In all Groups, IOP did not increase significantly after succinylcholine, but only anesthesia induced with propofol and alfentanil prevented the increase in IOP due to intubation.
Eti
Z
Z
Department of Anesthesia and Reanimation, Medical Faculty of Marmara University, Istanbul, Turkey.
Yayci
A
A
Umuroglu
T
T
Gögüş
F Y
FY
Bozkurt
N
N
D000328:Adult; D015760:Alfentanil / Q000008:administration & dosage*; D000771:Anesthesia, Intravenous / Q000379:methods; D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D017558:Elective Surgical Procedures; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007440:Intubation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects*; D009798:Ocular Hypertension / Q000209:etiology / Q000517:prevention & control*; D015742:Propofol / Q000008:administration & dosage*; D013390:Succinylcholine / Q000009:adverse effects*; D014132:Trachea
D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D009467:Neuromuscular Depolarizing Agents; D015760:Alfentanil; D013390:Succinylcholine; D015742:Propofol