[New approach to evaluating mutagenicity by cytogenetic techniques].
A two-population model that satisfactorily describes the emergence of multiaberrant cells during spontaneous mutagenesis is proposed. The model is based on the conception of existence of two cell populations. In the first basic part, the cells are distributed by the Poisson law. In the second rather small part, those are distributed in a geometric fashion. It is suggested that such distributions result from mutations in reparation and replication genes. These mutations determine higher incidence of chromosomal aberrations distributed by the geometrical law.
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D002869:Chromosome Aberrations / Q000235:genetics*; D020732:Cytogenetic Analysis; D004261:DNA Replication; D006801:Humans; D016296:Mutagenesis / Q000235:genetics*