Haptoglobin phenotypes in HIV-1-seropositive patients in Ghana: decreased risk for Hp0 individuals.
Plasma haptoglobin phenotypes were determined by polyacrylamide gel electrophoresis, followed by benzidine staining for 58 HIV-1 seropositive Ghanaians and 79 randomly selected age-matched controls. Hp0 was present in only 14% of HIV-1 seropositive individuals compared with more than 40% of the controls. The Hp0 individuals showed a highly significant reduced risk for HIV-1 infection (OR = 0. 21, 95% CI = 0.09-0.51, p = 0.0002). Hp0 may have a protective effect in HIV-1 infection.
Quaye
I K
IK
Noguchi Memorial Institute for Medical Research University of Ghana, Legon, Accra, Ghana. noguchi@ncs.com.gh
Ekuban
F A
FA
Brandful
J A
JA
Gyan
B A
BA
Akanmori
B D
BD
Ankrah
N A
NA
D004591:Electrophoresis, Polyacrylamide Gel; D005869:Ghana; D006679:HIV Seropositivity / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000302:isolation & purification; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D010641:Phenotype
D006242:Haptoglobins