title: Response of naïve and memory CD8+ T cells to antigen stimulation in vivo.
abstract: We studied the influence of memory T cell properties on the efficiency of secondary immune responses by comparing the in vivo immune response of the same numbers of T cell receptor (TCR) transgenic (Tg) naïve and memory T cells. Compared to naïve Tg cells, memory cells divided after a shorter lag time; had an increased division rate; a lower loss rate; and showed more rapid and efficient differentiation to effector functions. We found that initial naïve T cell priming resulted in cells expressing mutually exclusive effector functions, whereas memory T cells were multifunctional after reactivation, with each individual cell expressing two to three different effector functions simultaneously. These special properties of memory T cells ensure the immediate control of reinfection.
authors.affiliation: INSERM U.345, Institut Necker, Paris, France. veiga-femandes@necker.fr
authors.forename: H
authors.initials: H
authors.lastname: Veiga-Fernandes
authors.forename: U
authors.initials: U
authors.lastname: Walter
authors.forename: C
authors.initials: C
authors.lastname: Bourgeois
authors.forename: A
authors.initials: A
authors.lastname: McLean
authors.forename: B
authors.initials: B
authors.lastname: Rocha
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology; D015329:Gene Rearrangement, T-Lymphocyte / Q000276:immunology; D007156:Immunologic Memory; D051379:Mice; D008822:Mice, Transgenic; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*
chemical_list: D016827:CD8 Antigens; D004268:DNA-Binding Proteins; C499308:Rag2 protein, mouse; D011948:Receptors, Antigen, T-Cell; C064655:V(D)J recombination activating protein 2