[Results of treatment of lupus nephritis in children. Own experience].
The study aims at assessing the results of treating lupus nephritis in 31 children, aged 4-16 years at the diagnosis of the disease. Renal biopsy was performed in 29 patients. Patients were divided into 2 groups. Group 1 included 15 children treated in 1980-92 and group 2 included 16 children treated in 1993-98. The average age, sex and follow-up were similar in both groups. All children were treated with corticosteroids. Alkylating agents were administered to 12 patients in group 1 and in 14 in group 2. Group 2 patients were given cyclophosphamide in monthly intravenous pulses, and methylprednisolone according to the Mendoza regime. In Group 1, 8 remissions (53%) were observed. Better results with more aggressive treatment were obtained in group 2--13 remissions (81%).
Kwinta-Rybicka
J
J
Kliniki Nefrologii Dzieciecej Katedry Pediatrii Polsko-Amerykańskiego Instytutu Pediatrii Wydziału Lekarskiego UJ w Krakowie.
Sancewicz-Pach
K
K
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008181:Lupus Nephritis / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D008775:Methylprednisolone