title: Brady-tachycardia syndrome after radiotherapy for lung cancer. Assessment by computed tomography and carbon-11 methionine positron emission tomography.
abstract: A 74-year-old male who had received radiotherapy (total 54 Gy) for right lung cancer 7 months earlier developed a symptomatic brady-tachycardia syndrome requiring the implantation of a permanent pacemaker. Chest CT showed a pulmonary tumor of 2-cm diameter in the right lower lobe with direct extension into the surrounding tissue, suggesting the possibility of cardiac invasion. Carbon-11 methionine positron emission tomography (PET) indicated the absence of visible invasion of the heart with lung cancer. The bradytachycardia syndrome, therefore, was considered to be associated with sinus node injury due to radiation. Carbon-11 methionine PET metabolic imaging might play an important role in evaluating noninvasively the cause of the arrhythmia in this patient.
authors.affiliation: Third Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: O
authors.initials: O
authors.lastname: Okazaki
authors.forename: K
authors.initials: K
authors.lastname: Izumo
authors.forename: T
authors.initials: T
authors.lastname: Michihata
authors.forename: T
authors.initials: T
authors.lastname: Katagiri
authors.forename: K
authors.initials: K
authors.lastname: Harumi
mesh_terms: D000368:Aged; D001919:Bradycardia / Q000175:diagnosis* / Q000209:etiology; D002250:Carbon Radioisotopes; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008715:Methionine; D011878:Radiotherapy / Q000009:adverse effects*; D012849:Sinoatrial Node / Q000528:radiation effects; D013610:Tachycardia / Q000175:diagnosis* / Q000209:etiology; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D002250:Carbon Radioisotopes; D008715:Methionine