[Possible mechanisms of polyuria in progressive chronic renal failure].
OBJECTIVE
Elucidation of the role of saluresis and osmotic diuresis in renal function of patients with chronic renal failure.


METHODS
The trial included 68 subjects, among them 25 patients with chronic renal failure (CRF) of the third and fourth degree aged 16 to 72 years. Enzyme immunoassay was used to measure osmolality, sodium, potassium, magnesium, calcium and creatinine concentrations in the serum and urine as well as urine prostaglandin E2.


RESULTS
Renal function was studied in CRF patients with a 75-90% fall of glomerular filtration rate. Creatinine clearance was 19.9 +/- 0.96, it varied in different patients from 10.6 to 29.7 ml/min. It is shown that diuresis does not correlate with the total ion excretion (Na+ plus K+)(r = 0.946, p < 0.0001). A correlation was found between excretion of these ions and Mg2+ ions this indicating location of reabsorption reduction in the thick ascending limb of Henle loop. In CRF patients (Na+ plus K+) excretion correlated with PGE2 excretion (r = 0.65, p < 0.0001).


CONCLUSIONS
It is suggested that at this stage of chronic renal failure the mechanism of a diuresis increase is not due to osmotic diuresis but rather to secretion of prostaglandin E2 which inhibits cation reabsorption and stimulates diuresis. Differences are considered between osmotic diuresis and different types of saluresis; their possible mechanisms are discussed.
Natochin
Iu V
IuV
Bogolepova
A E
AE
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002118:Calcium / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D015232:Dinoprostone / Q000652:urine; D018450:Disease Progression; D004231:Diuresis / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D008274:Magnesium / Q000097:blood / Q000652:urine; D008875:Middle Aged; D009318:Natriuresis / Q000502:physiology; D009399:Nephrons / Q000378:metabolism* / Q000503:physiopathology; D009994:Osmolar Concentration; D011141:Polyuria / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D011188:Potassium / Q000097:blood / Q000652:urine; D011379:Prognosis; D012964:Sodium / Q000097:blood / Q000652:urine
D015415:Biomarkers; D012964:Sodium; D003404:Creatinine; D008274:Magnesium; D015232:Dinoprostone; D011188:Potassium; D002118:Calcium