Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein complex.
Genetic deficiency of the dystrophin-glycoprotein complex causes hereditary dilated cardiomyopathy. Enteroviruses can also cause cardiomyopathy and we have recently described a potential molecular mechanism for enterovirus-induced dilated cardiomyopathy. The coxsackieviral protease 2A proteolytically cleaves and functionally impairs dystrophin. Additionally, during infection with coxsackievirus B3, the dystrophin-glycoprotein complex becomes disrupted and the sarcolemmal integrity is lost. This review article discusses the importance of the dystrophin cleavage for the development of increased sarcolemmal permeability and potential pathways for mechanisms by which the dystrophin cleavage during coxsackieviral infection may contribute to dilated cardiomyopathy.
Badorff
C
C
Department of Medicine, University of California, San Diego, USA.
Lee
G H
GH
Knowlton
K U
KU
D002472:Cell Transformation, Viral / Q000235:genetics; D003384:Coxsackievirus Infections / Q000235:genetics / Q000821:virology*; D003588:Cytopathogenic Effect, Viral; D003598:Cytoskeletal Proteins / Q000235:genetics*; D049030:Dystroglycans; D029822:Enterovirus B, Human / Q000235:genetics*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D009205:Myocarditis / Q000235:genetics / Q000821:virology*
D003598:Cytoskeletal Proteins; C483081:DAG1 protein, human; D008562:Membrane Glycoproteins; D049030:Dystroglycans