title: Typical features of calciphylaxis in a patient with end-stage renal failure, diabetes mellitus and oral anticoagulation.
abstract: We report a multimorbid patient with end-stage renal failure showing a large necrosis and livedo racemosa on the right thigh. Histology revealed medial calcification of the small arteries typical of calciphylaxis. We found the typical features of the disease with different risk factors like elevated calcium-phosphate product, diabetes mellitus and oral anticoagulation. On account of the location of the skin lesions, a bad prognosis was expected. In spite of therapeutical measures with lowering of the calcium and phosphate levels, the patient died 1 month after the diagnosis had been made.
authors.affiliation: Dermatology, Inselspital, Bern, Switzerland. markus.streit@insel.ch
authors.forename: M
authors.initials: M
authors.lastname: Streit
authors.forename: B E
authors.initials: BE
authors.lastname: Paredes
authors.forename: S
authors.initials: S
authors.lastname: Rüegger
authors.forename: C U
authors.initials: CU
authors.lastname: Brand
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D002114:Calcinosis / Q000473:pathology; D002115:Calciphylaxis / Q000150:complications / Q000473:pathology*; D003327:Coronary Disease / Q000188:drug therapy / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D007868:Leg Dermatoses / Q000473:pathology; D017445:Skin Diseases, Vascular / Q000473:pathology
chemical_list: D000925:Anticoagulants