title: Mesigyna once-a-month combined injectable contraceptive: experience in Latin America.
abstract: A phase III clinical study was carried out among 534 fertile Latin American women to evaluate cycle control, side effects, and contraceptive efficacy of a once-a-month combined injectable, Mesigyna, consisting of 50 mg norethisterone enanthate and 5 mg estradiol valerate. The pregnancy rate at 1 year was 0 per 100 woman-years for a total experience of 4688 woman-months. The overall discontinuation rate at one year was 17.9%. Discontinuation rate for bleeding problems was 5.1%. The Colombian women had a significant increase (p <0.001) in bleeding problems compared to other countries. The discontinuation rate for amenorrhea was 1.1%. There were no significant differences between the groups regarding discontinuation for other medical or non-medical reasons. Mean weight gain after one year of use was 1.02 kg. Mesigyna is an appropiate once-a-month injectable contraceptive for Latin American women since it is highly effective and its perception of normal menstrual bleeding is of importance in the Latin American population.
authors.affiliation: Centro de Investigacion Biomedica Universidad, Autonoma de Coahuila, Mexico. sbassol@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Bassol
authors.forename: M C
authors.initials: MC
authors.lastname: Cravioto
authors.forename: M
authors.initials: M
authors.lastname: Durand
authors.forename: R
authors.initials: R
authors.lastname: Bailon
authors.forename: S
authors.initials: S
authors.lastname: Carranza
authors.forename: J
authors.initials: J
authors.lastname: Fugarolas
authors.forename: R
authors.initials: R
authors.lastname: Gaona
authors.forename: L M
authors.initials: LM
authors.lastname: Parada
authors.forename: C
authors.initials: C
authors.lastname: Celis
authors.forename: S
authors.initials: S
authors.lastname: Santoyo
authors.forename: J
authors.initials: J
authors.lastname: Garza-Flores
authors.forename: L
authors.initials: L
authors.lastname: Vazquez
authors.forename: C
authors.initials: C
authors.lastname: Lopez
authors.forename: C
authors.initials: C
authors.lastname: Gurucharri
authors.forename: J
authors.initials: J
authors.lastname: Novelli
authors.forename: H
authors.initials: H
authors.lastname: Carneiro de Oliveira
authors.forename: J
authors.initials: J
authors.lastname: Mendez
authors.forename: M E
authors.initials: ME
authors.lastname: de Andrade
authors.forename: N R
authors.initials: NR
authors.lastname: de Mello
authors.forename: K
authors.initials: K
authors.lastname: de Melo
authors.forename: E
authors.initials: E
authors.lastname: Chada
authors.forename: M E
authors.initials: ME
authors.lastname: Yassle
authors.forename: A
authors.initials: A
authors.lastname: Castañeda
authors.forename: P
authors.initials: P
authors.lastname: Gomez
authors.forename: C
authors.initials: C
authors.lastname: Arboleda
authors.forename: L
authors.initials: L
authors.lastname: Trujillo
authors.forename: R
authors.initials: R
authors.lastname: Bucheli
authors.forename: I
authors.initials: I
authors.lastname: Hidalgo
authors.forename: R
authors.initials: R
authors.lastname: Olavide
authors.forename: J
authors.initials: J
authors.lastname: Parejarios
authors.forename: J
authors.initials: J
authors.lastname: Succar
authors.forename: R
authors.initials: R
authors.lastname: Reyes-Marquez
authors.forename: G
authors.initials: G
authors.lastname: Albrecht
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced; D001794:Blood Pressure; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D004958:Estradiol / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007267:Injections; D007843:Latin America; D009640:Norethindrone / Q000031:analogs & derivatives*; D011247:Pregnancy; D014592:Uterine Hemorrhage / Q000139:chemically induced; D015430:Weight Gain
chemical_list: D003271:Contraceptive Agents, Female; D004338:Drug Combinations; C418365:estradiol, norethindrone drug combination; D004958:Estradiol; D009640:Norethindrone