5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait.
The purpose [corrected] of this study was to investigate the relationship between bipolar disorder and the harm avoidance personality trait (HA), and the genetic contribution of the polymorphic DNA variation T102C in exon 1 of 5-HTR2a (chromosome 13q14-21) in bipolar disorder and HA personality trait. Forty bipolar patients and 89 normal subjects completed the TPQ questionnaire and were genotyped for 5-HT2a. Bipolar patients scored higher than normal subjects on the HA dimension. However, no contribution of the 5-HTR2a polymorphism on the bipolar disorder or on the HA personality trait emerged. Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect.
Blairy
S
S
Department of Psychiatry, Free University of Brussels, Erasme Hospital, Belgium. sblairy@ulb.ac.be
Massat
I
I
Staner
L
L
Le Bon
O
O
Van Gestel
S
S
Van Broeckhoven
C
C
Hilger
C
C
Hentges
F
F
Souery
D
D
Mendlewicz
J
J
D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology*; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D015203:Reproducibility of Results; D017422:Sequence Analysis, DNA
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin