Melanisation of Cryptococcus neoformans in human brain tissue.
Melanin-specific reagents revealed melanin in cryptococcal cell walls from human brain tissue, and fungal-cell melanin "ghosts" were recovered from infected tissue. The results indicate that Cryptococcus neoformans melanises during human infection.
Nosanchuk
J D
JD
Rosas
A L
AL
Lee
S C
SC
Casadevall
A
A
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D003453:Cryptococcosis / Q000188:drug therapy / Q000378:metabolism*; D003455:Cryptococcus neoformans / Q000201:enzymology / Q000302:isolation & purification / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008543:Melanins / Q000096:biosynthesis*; D012377:Rodentia; D014268:Trifluoperazine / Q000627:therapeutic use
D000935:Antifungal Agents; D018492:Dopamine Antagonists; D008543:Melanins; D014268:Trifluoperazine; D000666:Amphotericin B