Regression of a presumed meningioma with the antiestrogen agent mepitiostane. Case report.
This 68-year-old woman underwent a distal gastrectomy for gastric cancer in August 1994. A presumed meningioma of the falx was found incidentally on a staging examination of the gastric cancer, but the meningioma was not treated with surgery. Instead, after gastrectomy the patient received tegafur as adjuvant chemotherapy until February 1996, when she was readmitted to the hospital because of loss of appetite and emaciation but with no recurrence of the gastric cancer. A computerized tomography scan obtained during this second admission showed no change in the meningioma. To improve her general condition, tegafur was discontinued and she was started on a course of the antiestrogen agent mepitiostane. Administration of mepitiostane for approximately 2 years resulted in a marked regression (73%) of the meningioma. This is the first reported case of a presumed meningioma that regressed as a result of use of the antiestrogen agent mepitiostane.
Oura
S
S
First Department of Surgery, Wakayama Medical College, Wakayama City, Japan.
Sakurai
T
T
Yoshimura
G
G
Tamaki
T
T
Umemura
T
T
Kokawa
Y
Y
Masuo
O
O
Naito
Y
Y
D000231:Adenocarcinoma, Papillary / Q000601:surgery; D000368:Aged; D000732:Androstanols / Q000009:adverse effects / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004965:Estrogen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008579:Meningioma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000732:Androstanols; D000970:Antineoplastic Agents; D004965:Estrogen Antagonists; C006242:mepitiostane