Cells and cytokines in the pathogenesis of inflammatory bowel disease: new insights from mouse T cell transfer models.
Recently, a number of experimental models of human inflammatory bowel disease (IBD) of immunological basis have been developed. These have proven useful tools in the study of IBD, allowing a more detailed dissection of the pathogenesis of the disease. Studies from these models have revealed new, important knowledge about environmental factors, cell subset, cytokines and effector molecules in the pathogenesis of IBD. This review focuses on recent advances in the understanding of the development of IBD obtained from adoptive CD4+ T cell transfer models of the disease.
Bregenholt
S
S
Laboratory of Experimental Immunology, Department of Medical Anatomy, University of Copenhagen, Copenhagen, Denmark. sbregenh@pasteur.fr
D019264:Adoptive Transfer; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology / Q000637:transplantation*; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D004195:Disease Models, Animal; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D051379:Mice
D016207:Cytokines