title: [Living-related liver transplantation--first experiences at Rabin Medical Center].
abstract: Our experience with living-related liver transplantation is described. In 2 boys and 1 girl, aged 4-4.5 years with acute, fulminating hepatitis A, the presence of very severe jaundice (bilirubin levels > 18 mg%) associated with severe coagulopathy (INR > 10) and encephalopathy indicated the need for urgent liver transplantation. In all 3 cases the left lateral hepatic segment of a matched blood type parent was transplanted. None of the donors suffered a serious complication postoperatively and all returned to full activity in 6-16 weeks. The post-transplantation course was uneventful in 1 child, but in the other 2 there was hepatic arterial thrombosis in 1 at 1 day and in the other at 8 days post-transplantation. Early detection of arterial thrombosis by Doppler sonography permitted salvage of the 2 hepatic grafts after thrombectomy and re-anastomosis. In 1 of these 2 children an anastomotic biliary stricture was found 2 months after transplantation. It was corrected at surgery and a percutaneous stent was inserted. All 3 children are alive with normal graft function at 2, 7 and 8 months post-transplantation, respectively. This initial experience indicates that living-related liver transplantation is feasible in Israel. The technique might help to solve our severe organ shortage for children awaiting liver transplantation.
authors.affiliation: Dept. of Transplantation, Rabin Medical Center, Petah Tikva.
authors.forename: N
authors.initials: N
authors.lastname: Bar-Nathan
authors.forename: Z
authors.initials: Z
authors.lastname: Shapira
authors.forename: E
authors.initials: E
authors.lastname: Shaharabani
authors.forename: A
authors.initials: A
authors.lastname: Yussim
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Ari
authors.forename: T
authors.initials: T
authors.lastname: Sheinfeld
authors.forename: I
authors.initials: I
authors.lastname: Zehavi
authors.forename: R
authors.initials: R
authors.lastname: Shapira
authors.forename: G
authors.initials: G
authors.lastname: Dinari
authors.forename: Z
authors.initials: Z
authors.lastname: Ben-Ari
authors.forename: R
authors.initials: R
authors.lastname: Tur-Kaspa
authors.forename: E
authors.initials: E
authors.lastname: Mor
mesh_terms: D000328:Adult; D002675:Child, Preschool; D005260:Female; D006498:Hepatectomy; D006501:Hepatic Encephalopathy / Q000601:surgery; D006506:Hepatitis A / Q000601:surgery; D006801:Humans; D019520:Living Donors; D008297:Male; D010290:Parents; D011183:Postoperative Complications