[Congenital manifestations of juvenile xanthogranuloma (large nodular form)].
An infant girl presented at birth with multiple, large nodular xanthogranulomas. Her monozygotic twin sister was not affected. The congenital tumors were up to 1.5 cm in diameter, done-shaped and mainly located on the head and the upper half of the body. Histologically the cells were characterized as CD68+ non-Langerhans histiocytes. Follow-up for 18 months showed no new tumors and regression of the existing ones. No extra-cutaneous manifestations were observed. Knowledge of the differential diagnosis, especially the group of Langerhans cell histiocytosis, is essential for prognosis estimation.
Jung
T
T
Abteilung für Dermatologie und Venerologie, Georg-August-Universität Göttingen.
Emmert
S
S
Günzl
H J
HJ
Neumann
C
C
Rünger
T M
TM
D001706:Biopsy; D003937:Diagnosis, Differential; D004200:Diseases in Twins; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012867:Skin / Q000473:pathology; D012868:Skin Abnormalities / Q000175:diagnosis* / Q000473:pathology; D014430:Twins, Monozygotic; D014972:Xanthogranuloma, Juvenile / Q000151:congenital* / Q000175:diagnosis / Q000473:pathology