Identification of candidate genes for psychiatric disorders on 18p11.
Linkage studies have suggested a locus for bipolar disorder as well as schizophrenia in the pericentric region of chromosome 18. Several candidate genes have been identified in the region including ACTH, IMP, and G(olf), however no reports of mutations in families showing linkage to the 18p11 locus have been reported. Recently, mild linkage disequilibrium has been observed with a polymorphic marker that maps within the G(olf) gene and schizophrenia in families from Germany and Israel, suggesting that a gene mapping near G(olf) may be involved in psychiatric disorders. A BAC and cosmid contig around the G(olf) locus has been generated and BAC clones were used for cDNA selection experiments. Several novel genes have been identified which are expressed in the brain. These genes may be possible candidate genes for psychiatric illness.
Rojas
K
K
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 233 S 10th Street, Suite 209, Philadelphia, PA 19107, USA.
Liang
L
L
Johnson
E I
EI
Berrettini
W H
WH
Overhauser
J
J
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D003360:Cosmids; D017931:DNA Primers; D018076:DNA, Complementary; D005192:Family Health; D008040:Genetic Linkage; D006801:Humans; D016133:Polymerase Chain Reaction; D012559:Schizophrenia / Q000235:genetics*
D017931:DNA Primers; D018076:DNA, Complementary