H107, a new aminoglycoside anti-Pseudomonas antibiotic produced by a new strain of Spirillospora.
Spirillospora spp. (strain 719) has been the source of several antibiotics. One of these designated H107 is produced as a trace. Compared with other antibiotics produced by the same strain, it was obtained only from the broth filtrate after precipitation with acetic acid followed by extraction with n-butanol. It was a water soluble metabolite active against Gram-negative bacteria and especially Pseudomonas spp., and was identified as an aminoglycoside compound. This is the first report of aminoglycoside anti-Pseudomonas production by Spirillospora.
Hacène
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H
Laboratoire de Microbiologie Appliquée, Unité de Recherche sur les Zones Arides, Université des Sciences et de la Technologie Houari-Boumediène, Alger, Algeria.
Daoudi-Hamdad
F
F
Bhatnagar
T
T
Baratti
J C
JC
Lefebvre
G
G
D000192:Actinomycetales / Q000737:chemistry*; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013045:Species Specificity
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C415942:antibiotic H107