title: Use of prevalence and incidence measures to describe age-related prescribing of antidepressants with and without anticholinergic effects.
abstract: To evaluate whether physicians avoid prescribing highly anticholinergic antidepressants (AAD) in the elderly, a population-based retrospectively data analysis was performed using databases from a Dutch health insurance company. Data collected on approximately 240,000 persons covered the period from 1 July 1993 to 1 January 1996. The prevalence and the incidence (number of new starters) of antidepressant use was measured over 1994 and 1995. Use of AAD was proportionally higher in the elderly in terms of both prevalence and incidence rates; the ratio of starters of AAD versus starters of non-AAD in 1994 increased steadily with age (from 0.54 in the age group 20-29 to 1.15 in the age group 60-69). In 1995 these incidence ratios decreased (0.41 to 0.99, respectively); however, the decrease was higher in the younger age groups. The data indicate that in the population studied, physicians do not refrain from prescribing highly anticholinergic agents to older patients despite their potential adverse drug reactions in this age group. This study also indicates that prevalence and incidence rates can be extracted from reimbursement data and give insight into actual prescribing practices.
authors.affiliation: Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Faculty of Pharmacy, P.O. Box 80082, 3508 TB, Utrecht, The Netherlands.
authors.forename: M E
authors.initials: ME
authors.lastname: van Eijk
authors.forename: P
authors.initials: P
authors.lastname: Bahri
authors.forename: G
authors.initials: G
authors.lastname: Dekker
authors.forename: R M
authors.initials: RM
authors.lastname: Herings
authors.forename: A
authors.initials: A
authors.lastname: Porsius
authors.forename: J
authors.initials: J
authors.lastname: Avorn
authors.forename: A
authors.initials: A
authors.lastname: de Boer
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D004363:Drug Utilization / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D017891:Pharmacoepidemiology; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D015995:Prevalence; D012189:Retrospective Studies
chemical_list: D000928:Antidepressive Agents; D018680:Cholinergic Antagonists