title: Relations between early prespike magnetic field changes, interictal discharges, and return to basal activity in the neocortex of rabbits.
abstract: To evaluate possible prespike field synchronizations, its relation to both interictal discharges and postspike return to baseline, penicillin-induced cortical interictal discharges were recorded in anaesthetized rabbits by magnetoencephalography (MEG) and electrocorticography (EcoG). Statistical parameters of spatial (global field power (GFP)) and temporal properties (Z-parameter) of field synchronization were calculated. In our previous report, three types of prespike field synchronization were found before the onset of interictal spike. We report here that the continuous and fluctuating, but not the abrupt prespike increases, were more often associated with a spike and wave pattern of interictal discharge than with a spike alone. Furthermore, the postspike return of these statistical parameters shows the same three patterns as the prespike field synchronizations, but in the inverse time sequence. More often than not pre- and postspike pattern were of the same type. The results suggest an influence of prespike field synchronization upon interictal discharge and subsequent field return dynamics.
authors.affiliation: Institute of Pathophysiology, Friedrich Schiller University, D-07740 Jena, 2, Nonnenplan, Germany. uzwi@mti-n.uni-jena.de
authors.forename: U
authors.initials: U
authors.lastname: Zwiener
authors.forename: M
authors.initials: M
authors.lastname: Eiselt
authors.forename: F
authors.initials: F
authors.lastname: Giessler
authors.forename: H
authors.initials: H
authors.lastname: Nowak
mesh_terms: D000818:Animals; D004569:Electroencephalography; D004574:Electromagnetic Fields; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D007033:Hypothalamus, Middle / Q000187:drug effects / Q000503:physiopathology; D015225:Magnetoencephalography; D019579:Neocortex / Q000187:drug effects / Q000503:physiopathology*; D010406:Penicillins / Q000008:administration & dosage; D011817:Rabbits; D013238:Stereotaxic Techniques
chemical_list: D010406:Penicillins