title: Efficacy in treatment of subclinical cervical HPV infection without intraepithelial neoplasia: systematic review.
abstract: BACKGROUND
  The treatment of the subclinical Human papillomavirus (HPV) infection of the uterine cervix is controversial.
  
  
  OBJECTIVE
  To assess the efficacy of any therapy for subclinical HPV infection of the cervix without intraepithelial neoplasia, via a search in the medical literature.
  
  
  METHODS
  We performed a systematic review with a comprehensive reference search in Medline, LILACS, Excerpta Medica, AIDSLINE, Popline, Cochrane Library and other authors' reference lists to identify experimental studies of therapy for subclinical HPV infection without intraepithelial neoplasia of the uterine cervix. In order to identify unpublished studies, we also contacted experts in the area, clinical trial registries, pharmaceutical industries, government and research institutions. We also searched on the Internet and in the book-of-abstracts of some medical conferences. The studies identified were masked and selected by inclusion criteria to help ascertain their internal validity. The data about regression or progression of HPV infection were extracted from the studies included.
  
  
  RESULTS
  We identified 67 studies related to the treatment of subclinical HPV infection without intraepithelial neoplasia of the uterine cervix. Only five clinical trials matched the inclusion criteria and none demonstrated significant differences between the experimental group and the control group concerning regression of HPV infection (with or without CIN I) or progression to higher grades of CIN.
  
  
  CONCLUSIONS
  The evidence we found in the medical literature regarding the efficacy of any therapy for subclinical HPV infection without intraepithelial neoplasia of the uterine cervix was unsatisfactory.
authors.affiliation: Department of Gynecology, Instituto Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Russomano
authors.forename: A
authors.initials: A
authors.lastname: Reis
authors.forename: M J
authors.initials: MJ
authors.lastname: de Camargo
authors.forename: M V
authors.initials: MV
authors.lastname: Dutra
authors.forename: S C
authors.initials: SC
authors.lastname: Fonseca
authors.forename: J
authors.initials: J
authors.lastname: Anderson
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology / Q000628:therapy*; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000473:pathology