title: Stroke in octogenarians undergoing coronary artery surgery with and without cardiopulmonary bypass.
abstract: BACKGROUND
  Myocardial revascularization in elderly patients is associated with a morbidity and a mortality substantially higher than those observed in younger patients. The aim of this study was to analyze the potential benefits of coronary artery bypass grafting without cardiopulmonary bypass (CPB) for octogenarians.
  
  
  METHODS
  Of 269 octogenarians who underwent coronary artery bypass grafting at our institution between January 1995 and May 1999, 172 had the operation with CPB (CPB group) and 97, without CPB (off-pump group). Revascularization of the circumflex system or right coronary artery were not considered contraindications to off-pump grafting. Demographic data, preoperative risk factors, comorbid conditions, angiographic findings, postoperative complications, and outcomes were compared.
  
  
  RESULTS
  The groups were comparable for age, sex, Canadian Cardiovascular Society class, operative priority (elective, urgent, or emergent), preoperative risk factors, and left ventricular ejection fraction. A significantly higher proportion of reoperations was observed in the off-pump cohort (16 of 97, 16.5%) compared with the CPB cohort (8 of 172, 4.7%) (p = 0.002). There was a trend toward a higher graft-patient ratio in the CPB group (3.3 versus 1.8; p = not significant). Freedom from postoperative complications was significantly higher in the off-pump group than in the CPB group (83 of 97, 85.6%, versus 129 of 172, 75%; p = 0.04). The incidence of stroke was 0% in the off-pump cohort compared with 9.3% (16 of 172) in the CPB cohort (p < 0.0005). Although there was a trend toward higher 30-day and risk-adjusted mortality rates in the off-pump group than in the CPB group (10.3% versus 5.2% and 2.8% versus 1.8%, respectively), the differences were not significant. The length of hospitalization was slightly lower in the off-pump group (9.1 versus 10.8 days; p = not significant).
  
  
  CONCLUSIONS
  This investigation suggests that patients 80 years of age and older undergoing off-pump coronary artery bypass grafting can experience significantly lower rates of perioperative stroke and overall complications compared with those undergoing the same procedure with CPB, although a trend toward higher mortality rates was observed in the off-pump group.
authors.affiliation: Division of Cardiothoracic Surgery and the Center for Minimally Invasive Cardiac Surgery, The Buffalo General Hospital, SUNY at Buffalo, New York 14203, USA.
authors.forename: M
authors.initials: M
authors.lastname: Ricci
authors.forename: H L
authors.initials: HL
authors.lastname: Karamanoukian
authors.forename: R
authors.initials: R
authors.lastname: Abraham
authors.forename: K
authors.initials: K
authors.lastname: Von Fricken
authors.forename: G
authors.initials: G
authors.lastname: D'Ancona
authors.forename: S
authors.initials: S
authors.lastname: Choi
authors.forename: J
authors.initials: J
authors.lastname: Bergsland
authors.forename: T A
authors.initials: TA
authors.lastname: Salerno
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D011183:Postoperative Complications; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome