Antimicrobial susceptibility of 1,422 Haemophilus influenzae isolates from respiratory tract infections in Spain. Results of a 1-year (1996-97) multicenter surveillance study. Spanish Surveillance Group for Respiratory Pathogens.
A Haemophilus influenzae multicenter antimicrobial susceptibility surveillance was carried out. An overall beta-lactamase production rate of 25.7% was found, with significant differences between hospitals ranging between 7.9 and 47.9%. Presumable intrinsic resistance was found in 4.6% of strains. No differences in susceptibility were observed between beta-lactamase positive and beta-lactamase negative strains for all antibiotics, except for penicillin, amoxicillin and cefaclor. A higher prevalence of resistance was found for clarithromycin vs azithromycin (22.6 vs 0.7%). Differences in all these factors make surveillance essential as a guideline for empiric treatment in community-acquired respiratory tract infections.
García-Rodríguez
J A
JA
University Hospital, Salamanca, Spain.
Baquero
F
F
García de Lomas
J
J
Aguilar
L
L
D004352:Drug Resistance, Microbial; D006192:Haemophilus Infections / Q000188:drug therapy* / Q000453:epidemiology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D012680:Sensitivity and Specificity; D013030:Spain / Q000453:epidemiology