The pharmacokinetics and metabolism of sucralose in the rabbit.
The excretion and metabolism of (14)C-sucralose has been investigated in non-pregnant and pregnant rabbits after administration of single 10mg/kg oral doses. Means of 22% and 55% of the dose were excreted in urine and faeces, respectively, by non-pregnant animals during 5 days. Excretion was similar in pregnant animals with means of 22% and 65% of the dose in urine and faeces, respectively, during the same time. Following a single oral dose, a mean of approximately 7% of the dose was still being excreted during the 96-120-hr collection period. Only one major radioactive component was detected in urine samples which corresponded to unchanged sucralose.
John
B A
BA
Huntingdon Research Centre Ltd, Huntingdon, Cambs PE18 6ES, UK.
Wood
S G
SG
Hawkins
D R
DR
D000042:Absorption / Q000502:physiology; D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes / Q000652:urine; D002855:Chromatography, Thin Layer; D005243:Feces / Q000737:chemistry; D005260:Female; D011247:Pregnancy; D011817:Rabbits; D012588:Scintillation Counting; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D013549:Sweetening Agents / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D013549:Sweetening Agents; D013395:Sucrose; C026285:trichlorosucrose