Transient beneficial effect of GH replacement therapy and topical GH application on skin ulcers in a boy with prolidase deficiency.
A diagnostic examination for short stature in a boy with chronic ulcers of the feet due to prolidase deficiency, a rare disorder associated with intractable ulcers of the skin, led to the diagnosis of growth hormone (GH) deficiency. Replacement treatment with r-hGH associated with the topical application of a GH-containing ointment when the boy was 13 years old resulted in complete but transitory healing of the ulcers, which can probably be attributed to the growth-promoting effects of GH on dermal connective tissue.
Monafo
V
V
Department of Pediatric Sciences, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. gl.marseglia@smatteo.pv.it
Marseglia
G L
GL
Maghnie
M
M
Dyne
K M
KM
Cetta
G
G
D000293:Adolescent; D002648:Child; D004150:Dipeptidases / Q000172:deficiency*; D016523:Foot Ulcer / Q000188:drug therapy; D013006:Growth Hormone / Q000008:administration & dosage / Q000172:deficiency* / Q000627:therapeutic use*; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male; D009824:Ointments; D011994:Recombinant Proteins / Q000627:therapeutic use; D012883:Skin Ulcer / Q000188:drug therapy*
D009824:Ointments; D011994:Recombinant Proteins; D013006:Growth Hormone; D004150:Dipeptidases; C022449:proline dipeptidase