title: Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold.
abstract: [structure: see text] Receptors based on a tetraphenylporphyrin scaffold bearing different charged and hydrophobic groups have been synthesized. The interactions of these with horse heart cytochrome c were studied by fluorescence spectroscopy. Receptor 4 was identified to be the strongest synthetic receptor (K(d) = 20 nM) for cytochrome c. The differences in affinity among the receptors reflected a dependence on the number of anionic and hydrophobic groups.
authors.affiliation: Department of Chemistry, Yale University, New Haven, CT 06520-8107, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Jain
authors.forename: A D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D003574:Cytochrome c Group / Q000737:chemistry / Q000378:metabolism*; D018716:Molecular Mimicry; D011166:Porphyrins / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D013050:Spectrometry, Fluorescence
chemical_list: D003574:Cytochrome c Group; D011166:Porphyrins; C409084:tetraphenylporphyrin