Carcinoembryonic antigen family of adhesion molecules in the cotton top tamarin (Saguinus oedipus).
Humans and the cotton top tamarin, a model for colitis and colorectal cancer, share carcinoembryonic antigen (CEA) moieties. We quantified CEA in colonic washings and extracts in both, and CEA bands were confirmed by Western blot. We compared CEA-family expression in tissues and serum in the tamarin with that of the common marmoset, which develops colitis but not cancer. CEA levels are higher in tamarin washings compared with humans, and higher than in marmosets extracts (P<0.005). CEA molecular species appear to be specific, and human CEA-family member epitopes are also found in these primates. The higher CEA levels in the tamarin may reflect the overall higher cancer prevalence.
Tobi
M
M
Department of Medicine, John D. Dingell VAMC, Center for Molecular Medicine, Wayne State University, Detroit, MI 48201, USA. tobi.martin@allen-park.va.gov
Chintalapani
S
S
Kithier
K
K
Clapp
N
N
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D015153:Blotting, Western; D002144:Callithrix; D002272:Carcinoembryonic Antigen / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000097:blood / Q000276:immunology / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D006801:Humans; D011933:Reagent Kits, Diagnostic; D012452:Saguinus / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D000939:Epitopes; D011933:Reagent Kits, Diagnostic