The possible role of myocardial biopsy in systemic sclerosis.
The histopathological features of heart involvement in systemic sclerosis (SSc) are not widely known. In internal and transplantation medicine, myocardial biopsies are increasingly used to diagnose cardiomyopathies including myocarditis. In two SSc patients presenting with dyspnoea with no evidence of pulmonary involvement, the cause of the compromised heart function was sought by myocardial biopsy. Immunohistological analysis revealed an increased number of CD3+ + T cells indicating myocarditis in one, and increased amounts of fibroblasts in both SSc patients. The authors think that myocardial involvement in SSc should be differentially evaluated and they propose the use of myocardial biopsies as a tool to distinguish between inflammatory and fibrotic forms of heart involvement in SSc patients.
Liangos
O
O
Department of Nephrology and Rheumatology, Freie Universität Berlin, Berlin, Germany.
Neure
L
L
Kühl
U
U
Pauschinger
M
M
Sieper
J
J
Distler
A
A
Schwimmbeck
P L
PL
Braun
J
J
D001706:Biopsy; D017252:CD3 Complex / Q000032:analysis; D005260:Female; D005355:Fibrosis / Q000209:etiology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009205:Myocarditis / Q000209:etiology / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D012595:Scleroderma, Systemic / Q000150:complications / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology
D017252:CD3 Complex