title: [18F]fluorodeoxyglucose positron emission tomography in the diagnosis of cancer in patients with paraneoplastic neurological syndrome and anti-Hu antibodies.
abstract: The diagnosis of cancer is often difficult in patients with paraneoplastic neurological syndrome and anti-Hu antibodies. Fluorodeoxyglucose 18 positron emission tomography scanning is a highly sensitive and specific method to detect lung tumors. We investigated 15 patients with paraneoplastic neurological syndrome and anti-Hu antibodies. Radiological methods led to the diagnosis of cancer in 12 patients, and test results were negative in 3. Whole-body [18F]fluorodeoxyglucose positron emission tomography showed abnormal uptake in the mediastinum in these 3 patients in accordance with the expected location of the malignancy.
authors.affiliation: Service de Neurologie, Hôpital de Bellevue, Faculté de Médecine Jacques Lisfranc, Saint-Etienne, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Antoine
authors.forename: L
authors.initials: L
authors.lastname: Cinotti
authors.forename: C
authors.initials: C
authors.lastname: Tilikete
authors.forename: F
authors.initials: F
authors.lastname: Bouhour
authors.forename: J P
authors.initials: JP
authors.lastname: Camdessanché
authors.forename: C
authors.initials: C
authors.lastname: Confavreux
authors.forename: A
authors.initials: A
authors.lastname: Vighetto
authors.forename: V
authors.initials: V
authors.lastname: Renault-Mannel
authors.forename: D
authors.initials: D
authors.lastname: Michel
authors.forename: J
authors.initials: J
authors.lastname: Honnorat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D051959:ELAV Proteins; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000000981:diagnostic imaging* / Q000276:immunology*; D016601:RNA-Binding Proteins / Q000276:immunology*; D014055:Tomography, Emission-Computed
chemical_list: D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D019788:Fluorodeoxyglucose F18