title: Bone cells and matrices in orthopedic tissue engineering.
abstract: The ability to harvest and manipulate osteogenic cells gives clinicians the opportunity to harness capacity of these cells for targeted regeneration and repair of skeletal tissues. Further opportunities to optimize use of cells exist in the ability to design specialized matrices that act as conductive scaffolds. Realization of the full potential of engineered matrix materials and cell-matrix composites can provide new solutions to many clinical problems in skeletal reconstruction.
authors.affiliation: Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Fleming
authors.forename: C N
authors.initials: CN
authors.lastname: Cornell
authors.forename: G F
authors.initials: GF
authors.lastname: Muschler
mesh_terms: D001857:Bone Matrix / Q000166:cytology*; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation; D001842:Bone and Bones / Q000166:cytology*; D020099:Coated Materials, Biocompatible; D046508:Culture Techniques; D006801:Humans; D019637:Orthopedic Procedures; D020858:Tissue and Organ Harvesting
chemical_list: D020099:Coated Materials, Biocompatible