NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus.
A system for performing NMR imaging experiments on drug delivery devices within a flow-through dissolution apparatus, USP Apparatus 4, has been developed. The system was used to image the physical changes that occur in solid dosage forms during dissolution in the flow-through apparatus. Simultaneous cumulative drug release measurements were also made. The NMR images obtained under these conditions and the drug release data provide a better understanding of the processes involved in the release of drugs from drug delivery systems based on diffusion, dissolution and osmosis mechanisms.
Fyfe
C A
CA
Department of Chemistry, University of British Columbia, V6T 1Z1, Vancouver, BC, Canada.
Grondey
H
H
Blazek-Welsh
A I
AI
Chopra
S K
SK
Fahie
B J
BJ
D016503:Drug Delivery Systems / Q000379:methods; D007785:Lactose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D010078:Oxazines; D013607:Tablets / Q000493:pharmacokinetics
D010078:Oxazines; D013607:Tablets; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose