title: Postextrasystolic contractile decay always contains exponential and alternans components in canine heart.
abstract: In isolated, blood-perfused canine hearts, postextrasystolic potentiation (PESP) decays monotonically after a noncompensatory pause following a spontaneous extrasystole (ES). The monotonic PESP decay yields myocardial internal Ca(2+) recirculation fraction (RF). We have found that after a compensatory pause (CP), PESP decays in alternans, consisting of an exponential and a sinusoidal decay component. We have proposed that this exponential component also yields RF. In the present study, we examined the reliability of this alternative method by widely changing the ES coupling interval (ESI), CP, and heart rate in the canine excised, cross-circulated left ventricle. We found that all PESP decays consisted of the sum of an exponential and a sinusoidal decay component of variable magnitudes whether a CP existed or not. Their decay constants as well as the calculated RF were independent of the ESI and CP. This confirmed the utility of our alternative RF determination method regardless of the ESI, CP, and heart rate. Direct experimental evidence of Ca(2+) dynamics supportive of this alternative method, however, remains to be obtained.
authors.affiliation: Department of Physiology II, Okayama University Medical School, Okayama 700-8558, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Shimizu
authors.forename: J
authors.initials: J
authors.lastname: Araki
authors.forename: G
authors.initials: G
authors.lastname: Iribe
authors.forename: T
authors.initials: T
authors.lastname: Imaoka
authors.forename: S
authors.initials: S
authors.lastname: Mohri
authors.forename: K
authors.initials: K
authors.lastname: Kohno
authors.forename: H
authors.initials: H
authors.lastname: Matsubara
authors.forename: T
authors.initials: T
authors.lastname: Ohe
authors.forename: M
authors.initials: M
authors.lastname: Takaki
authors.forename: H
authors.initials: H
authors.lastname: Suga
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D005117:Cardiac Complexes, Premature / Q000503:physiopathology*; D003326:Coronary Circulation; D004285:Dogs; D004562:Electrocardiography; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006339:Heart Rate; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D002118:Calcium