Ongoing research on mammalian cloning and embryo stem cell technologies: bioethics of their potential medical applications.
Reproduction by cloning has been achieved by transfer into enucleated oocytes of nuclei from embryonic cells and more recently from cells of adult animals. The efficiency at which embryos produced by such nuclear transfers will develop into healthy newborns is very low but has succeeded in producing some cloned bovines, ovines and mice. Since the first report of sheep cloning from an adult cell in 1997, the potential applications of reproductive cloning in human medicine have been envisaged amidst a flurry of moral debates. Although the technology is still far from being ready for any human use, it has been condemned up front. It has also led to irrational fantasies and fears, based mainly on the misconception that genetic identity means identical twin personalities. Scientific research is ongoing to refine the cloning technology for applications in the production of genetically homogeneous farm animals with useful nutritional or therapeutic genetic traits. A new area of research is non-reproductive therapeutic cloning for the purpose of producing autologous embryonic cells and tissues for transplantation.
Revel
M
M
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. lvrevel@wis.weizmann.ac.il
D000822:Animal Husbandry; D000818:Animals; D001675:Bioethics; D002417:Cattle; D019976:Cloning, Organism; D005818:Genetic Engineering; D015894:Genome, Human; D006801:Humans; D008322:Mammals; D013677:Medical Laboratory Science; D051379:Mice; D053652:Nuclear Transfer Techniques; D009865:Oocytes; D010551:Personality / Q000235:genetics; D012099:Reproductive Techniques; D012756:Sheep; D013234:Stem Cells / Q000502:physiology*; D016378:Tissue Transplantation; D014182:Transplantation, Autologous; D014430:Twins, Monozygotic / Q000235:genetics