In vitro activities of MK-826 (L-749,345) against 363 strains of anaerobic bacteria.
The activity of MK-826 was compared to the activities of cefoxitin, ceftriaxone, imipenem, and meropenem against 363 gram-negative and gram-positive anaerobes by using NCCLS procedures. At least 98% of the strains were susceptible to the carbapenems. All strains of Clostridium perfringens, Fusobacterium nucleatum, Peptostreptococcus, and Sutterella wadsworthensis were susceptible to all agents tested.
Wexler
H M
HM
Research Services, Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA. hwexler@ucla.edu
Molitoris
D
D
Finegold
S M
SM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D003016:Clostridium perfringens / Q000187:drug effects; D016967:Fusobacterium nucleatum / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010462:Peptostreptococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D015780:Carbapenems; C118072:MK 826