[Epidemiology and clinical course of HCV infection in children and adolescents with chronic renal failure].
The aim of the study was to evaluate epidemiology and clinical course of HCV infection in children and adolescents with end-stage renal disease. The study involved 70 patients, aged 1-25 years, 31 M, 39 F: group of 40 dialysed (27 HD, 13 CAPD) and 30 patients suffering from different chronic renal disease as a control group. Anti-HCV antibodies were assayed by EIA 3rd gene (Abbott Diagnostic) and were sought by LIATEK HCV 3rd gene. HCv RNA was detected and measured by a standardised HCV RNA PCR assay (Amplicor Roche). HCV genotypes were identified by InnoLIPA (Innogenetics). HCV infection was diagnosed in 20 (50%) dialysed and in 3 (10%) non-dialysed patients. None of the HCV infected patients presented the clinical symptoms of hepatitis; the mild activity of ALT was observed in 8 cases only. HCV viremia was relatively low: 365 x 103 copies/mL in PD and 110,9 x 103 copies/mL in HD patients. 3 genotypes of HCV were identified: 1a, 1b and 4c/4d. In 3 cases liver biopsy was performed, no cirrhosis was diagnosed.
Inglot
M
M
Katedry i Kliniki Chorób Zakaźnych Akademii Medycznej we Wrocławiu.
Berny
U
U
Zalewska
M
M
Zwolińska
D
D
Gładysz
A
A
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification*; D006508:Hepatitis Antibodies / Q000276:immunology; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology / Q000821:virology; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D012720:Severity of Illness Index
D006508:Hepatitis Antibodies