title: Effects of ENU dosage on mouse strains.
abstract: The germline supermutagen, N-ethyl-N-nitrosourea (ENU), has a variety of effects on mice. ENU is a toxin and carcinogen as well as a mutagen, and strains differ in their susceptibility to its effects. Therefore, it is necessary to determine an appropriate mutagenic, non-toxic dose of ENU for strains that are to be used in experiments. In order to provide some guidance, we have compiled data from a number of laboratories that have exposed male mice from inbred and non-inbred strains or their F(1) hybrids to ENU. The results show that most F(1) hybrid animals tolerate ENU well, but that inbred strains of mice vary in their longevity and in their ability to recover fertility after treatment with ENU.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. M.justice@bcm.tmc.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Justice
authors.forename: D A
authors.initials: DA
authors.lastname: Carpenter
authors.forename: J
authors.initials: J
authors.lastname: Favor
authors.forename: A
authors.initials: A
authors.lastname: Neuhauser-Klaus
authors.forename: M
authors.initials: M
authors.lastname: Hrabé de Angelis
authors.forename: D
authors.initials: D
authors.lastname: Soewarto
authors.forename: A
authors.initials: A
authors.lastname: Moser
authors.forename: S
authors.initials: S
authors.lastname: Cordes
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: V
authors.initials: V
authors.lastname: Chapman
authors.forename: J S
authors.initials: JS
authors.lastname: Weber
authors.forename: E M
authors.initials: EM
authors.lastname: Rinchik
authors.forename: P R
authors.initials: PR
authors.lastname: Hunsicker
authors.forename: W L
authors.initials: WL
authors.lastname: Russell
authors.forename: V C
authors.initials: VC
authors.lastname: Bode
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005038:Ethylnitrosourea / Q000494:pharmacology* / Q000633:toxicity; D006824:Hybridization, Genetic; D007248:Infertility, Male / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains
chemical_list: D005038:Ethylnitrosourea