[The neuromediator modulation of the ionic composition of the brain cells in rats irradiated at nonlethal doses].
It had been found that both the single prolonged irradiation and chronic (fractionated) one with doses of 25 and 50 cGy (1.75 mGy/min) caused essential modification of the biphase modulative effects of acetylcholine and gamma-aminobutyric acid upon K+ level in rat brain cortex slices to be compared to the acute lethal irradiation influence. The results of model experiments showed saturated fatty acids to be significant for the changes in regulative functions of nerve cell membranes after exposure to low dose-rate radiation.
Anan'eva
T V
TV
Research Institute of Biology, Dnepropetrovsk University, Ukraine.
Dvoretskiĭ
A I
AI
D000109:Acetylcholine / Q000494:pharmacology / Q000528:radiation effects; D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D007477:Ions; D008297:Male; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000528:radiation effects*; D011188:Potassium / Q000378:metabolism / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology / Q000528:radiation effects
D007477:Ions; D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D011188:Potassium