The clinicopathologic spectrum of cytotoxic lymphomas of the skin.
Cytotoxic lymphomas of the skin comprise a spectrum of peripheral T cell and natural killer cell lymphomas with primary or secondary skin manifestations. They comprise a broad, heterogeneous group of lymphoproliferative disorders, and are characterized by expression of cytotoxic proteins (TIA-1, granzyme A and B, and perforin). These lymphomas often show an aggressive clinical course. In this article a detailed description of clinical, histopathologic, immunohistochemical, and molecular characteristics of cutaneous cytotoxic lymphomas follows a brief introduction on cytotoxic lymphocytes.
El Shabrawi-Caelen
L
L
Department of Dermatology, University of Graz, Austria.
Cerroni
L
L
Kerl
H
H
D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D011379:Prognosis; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism*