The role of RANTES in meningococcal disease.
The chemokine RANTES (regulated on activation, normal T cell expressed and secreted) is a potent regulator of leukocyte trafficking. RANTES preferentially attracts mature CD4 cells as well as macrophages and eosinophils, but not neutrophils. In total, 128 children with meningococcal disease were prospectively studied, and the role of RANTES in the pathophysiology of meningococcal disease was assessed. Plasma RANTES, interleukin (IL)-8, IL-6, IL-1 receptor agonist, and tumor necrosis factor-alpha were measured at admission. Severity of disease was stratified by the Glasgow meningococcal septicemia prognostic score (GMSPS). RANTES levels correlated significantly with IL-8 levels, admission lactate levels, platelets, prothrombin time, and activated partial thromboplastin time. RANTES levels were lower in children with severe disease (GMSPS>/=8; P=.001), in those with septic shock (P<.0005), and in nonsurvivors (P=.048; Mann-Whitney test). RANTES is a potential mediator in the pathophysiology of meningococcal disease.
Carrol
E D
ED
Institute of Child Health, Royal Liverpool Children's Hospital, NHS Trust (Alder Hey), Liverpool, L12 2AP, Liverpool, UK. edcarrol@liv. edcarrol@liv.ac.uk
Thomson
A P
AP
Mobbs
K J
KJ
Hart
C A
CA
D000293:Adolescent; D002465:Cell Movement; D018946:Chemokine CCL5 / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008213:Lymphocyte Activation; D008297:Male; D008589:Meningococcal Infections / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D011446:Prospective Studies
D018946:Chemokine CCL5; D016207:Cytokines; D018799:Intercellular Adhesion Molecule-1