HLA-A*6817, identified in the Kolla Amerindians of North-West Argentina possesses a novel nucleotide substitution.
Analysis of HLA polymorphism of the indigenous populations of Central and South America has identified many alleles not seen previously in other populations. We have described a novel allele, B*5113, previously in a Kolla Amerindian individual from North-West Argentina. Here we present a second novel allele from this population: A*6817, which differs from its closest neighbour A*68012 by a single substitution at nucleotide 419. This substitution of adenosine 419 A*68012 for thymidine in A*6817 results in a novel amino acid change (aspartate to valine) at residue 116.
Ramon
D
D
Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
Scott
I
I
Cox
S T
ST
Pesoa
S
S
Vullo
C
C
Little
A M
AM
Madrigal
J A
JA
D001118:Argentina; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide
D015234:HLA-A Antigens