Changes in cerebral hemodynamics during simple partial motor seizures.
Changes in cerebral perfusion were studied during nine short-lasting simple partial motor seizures (SPS) in an 11-year-old girl. Blood flow velocity changes in both middle cerebral arteries (MCAs) were assessed by transcranial Doppler sonography during simultaneous EEG monitoring. Within 7.4 +/- 1.4 s after electroencephalographic seizure onset, flow velocity in the MCA ipsilateral to the electrical discharges started to increase and then gradually rose up to 70% above baseline values. Spread of the epileptic activity to the other hemisphere in the late stage of seizure was associated with a slight increase in blood flow velocity (<30%) in the contralateral MCA. After the end of the seizure, flow velocities returned to baseline within 47 +/- 7 s. Our findings indicate that focal epileptic seizures evoke asymmetric perfusion increases which are closely related to the onset and cessation of the electroencephalographic seizure activity.
Niehaus
L
L
Department of Neurology, Charité, Campus Virchow Klinikum, Humboldt University, Berlin, Germany.
Wieshmann
U C
UC
Meyer
B
B
D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002648:Child; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004576:Electromyography; D020938:Epilepsy, Partial, Motor / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D020768:Middle Cerebral Artery / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology; D017585:Ultrasonography, Doppler, Transcranial