Apoptosis.
Apoptosis is the genetically regulated form of cell death that permits the safe disposal of cells at the point in time when they have fulfilled their intended biological function. Examples of apoptosis can be cited throughout the whole of the animal and plant kingdoms. It is a vitally important process during normal development and the adult life of many living organisms. In humans, dysregulation of apoptosis can result in inflammatory, malignant, autoimmune, and neurodegenerative diseases. In addition, infectious agents, including viruses, exploit cellular apoptosis in the host to evade the immune system. This review gives a brief historical perspective of some of the landmark discoveries in apoptosis research. The morphological and biochemical stages of apoptosis are then covered, followed by an overview of how it can be studied in the laboratory. Finally, the implications for therapeutic intervention in disease treatment are discussed.
Afford
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S
Liver Research Laboratories, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK. s.c.afford@bham.ac.uk
Randhawa
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D000818:Animals; D030801:Animals, Genetically Modified; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D017173:Caenorhabditis elegans / Q000235:genetics; D020169:Caspases / Q000502:physiology; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology; D009154:Mutation; D009336:Necrosis; D012106:Research; D015398:Signal Transduction / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D014409:Tumor Necrosis Factor-alpha; D020169:Caspases