In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans.
The antifungal activity of nyasol (NYS) alone or with various antifungal agents was measured in vitro against Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. NYS is a compound recently purified from a medicinal plant, Anemarrhena asphodeloides. Among 12 agents, miconazole (MCZ), ketoconazole (KCZ), clotrimazole (CTZ), and cerulenin showed marked synergistic effects against C. albicans. The fractional inhibition concentration (FIC) indices against 4 strains of C. albicans were 0.067-0.31 for MCZ plus NYS, 0.078-0.31 for KCZ plus NYS, and 0.098-0.13 for CTZ plus NYS. These values indicate the possibility of using NYS as an adjuvant to azole agents in the chemotherapy of candidiasis.
Iida
Y
Y
Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology, Japan.
Oh
K B
KB
Saito
M
M
Matsuoka
H
H
Kurata
H
H
D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D001393:Azoles / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004357:Drug Synergism; D005658:Fungi / Q000187:drug effects*; D017705:Lignans; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; D001393:Azoles; D017705:Lignans; D010636:Phenols; C109393:nyasol