title: Endoscopic laser surgery in the treatment of radiation failure of early laryngeal carcinoma.
abstract: BACKGROUND
  This study was undertaken to analyze the local control rates and survival of patients undergoing endoscopic laser surgery for squamous cell carcinoma of the larynx as a salvage procedure for recurrent tumors after radiotherapy.
  
  
  METHODS
  Twenty-four patients underwent endoscopic laser surgery for radiation failure at our hospital from 1988 to 1995. All patients were men, between 45 and 88 years old. The localization of the recurrence was in the supraglottis in 3 cases and in the glottis in 21 cases. The postirradiation recurrences were staged rT1 in 18 patients and rT2 in 6 patients.
  
  
  RESULTS
  Local recurrence after laser surgery developed in six patients (25%) who had a total laryngectomy. Voice preservation was thus achieved in 75% of patients. No patient died because of the laryngeal cancer, and the observed 5-year survival rate was 76%.
  
  
  CONCLUSIONS
  These results indicate that in selected cases, endoscopic laser surgery may be used successfully for treating radiation failure of early laryngeal carcinomas.
authors.affiliation: Department of Otorhinolaryngology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Quer
authors.forename: X
authors.initials: X
authors.lastname: León
authors.forename: C
authors.initials: C
authors.lastname: Orús
authors.forename: P
authors.initials: P
authors.lastname: Venegas
authors.forename: M
authors.initials: M
authors.lastname: López
authors.forename: J
authors.initials: J
authors.lastname: Burgués
mesh_terms: D000206:Actuarial Analysis; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery*; D016001:Confidence Intervals; D005500:Follow-Up Studies; D005931:Glottis / Q000473:pathology / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods; D007828:Laryngoscopy; D007829:Laryngostenosis / Q000209:etiology; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D016879:Salvage Therapy; D015996:Survival Rate; D017211:Treatment Failure; D014831:Voice / Q000502:physiology