Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2).
A case of extraskeletal myxoid chondrosarcoma (EMC) in which there was histochemical, immunohistochemical, and ultrastructural evidence of neuroendocrine differentiation is reported. Genetic investigations showed the recently described novel translocation t(9;17)(q22;q11.2) and associated fusion of the CHN and RBP56 genes, contrasting with the translocation t(9;22)(q22;q12) and EWS/CHN gene fusion found in the majority of EMCs.
Harris
M
M
Department of Histopathology, Christie Hospital, Manchester, UK.
Coyne
J
J
Tariq
M
M
Eyden
B P
BP
Atkinson
M
M
Freemont
A J
AJ
Varley
J
J
Attwooll
C
C
Telford
N
N
D014408:Biomarkers, Tumor / Q000032:analysis; D002081:Buttocks; D002454:Cell Differentiation; D002813:Chondrosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003582:Cytogenetics; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000378:metabolism / Q000473:pathology*; D011347:Procollagen / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000235:genetics; D016622:Silver Staining; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor; D011347:Procollagen; D012333:RNA, Messenger; D012334:RNA, Neoplasm