Role of brain angiotensin II in renal nerve inhibition elicited by volume expansion in the conscious rabbit.
Losartan (10 microg/25 microl) or vehicle was injected into the fourth brain ventricle prior to volume expansion (VE) with Haemaccel (2 ml/min for 30 min). RSNA was reduced by a maximum of 45% in response to the VE following vehicle and by 33% following losartan. There was no significant difference between the treatments in RSNA, nor in the blood pressure and heart rate responses. We conclude that endogenous angiotensin II does not make a major contribution to the reflex reduction in RSNA initiated by VE.
Badoer
E
E
Department of Medicine, Monash Medical Centre, Monash University, 246 Clayton Rd, Clayton 3168, Victoria, Melbourne, Australia. emilio.badoer@rmit.edu.au
Ryan
A
A
De Matteo
R
R
D000804:Angiotensin II / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003243:Consciousness / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007668:Kidney / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism; D019808:Losartan / Q000494:pharmacology; D008297:Male; D011097:Polygeline / Q000494:pharmacology; D011817:Rabbits; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D013153:Splanchnic Nerves / Q000187:drug effects / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology*
D000804:Angiotensin II; D011097:Polygeline; D019808:Losartan