[The role of cytochrome p450 in metabolism of S-ethynylthiophosphates].
We studied interaction between S-ethynyl ethers of phosphorus acids with cytochrome P-450 from rat liver and housefly abdomen. High thionic effect, i.e., considerable selectivity for the studied compounds in homoiotherms and arthropods, proved to the related to the triple bond in these compounds. Apparently, cytochrome P-450 participates in S-ethynylthiophosphates metabolism and breaks the P-S bond. This gives rise to "self-destroying" metabolites, namely, alkylthioketenes, which decelerate deactivation reactions through destruction of the corresponding isoform of cytochrome P-450 in the microsomal fraction in both homoiotherms and insects. However, the activation reaction goes much faster in insects than in homoiotherms.
Vikhreva
L A
LA
Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia.
Pudova
T A
TA
Godovikov
N N
NN
Kabachnik
M I
MI
Salganik
R Ia
RIa
Nedel'kina
S V
SV
D000480:Alkynes / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006793:Houseflies; D066298:In Vitro Techniques; D008861:Microsomes / Q000201:enzymology / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D009946:Organothiophosphorus Compounds / Q000378:metabolism*; D051381:Rats; D013045:Species Specificity
D000480:Alkynes; D009946:Organothiophosphorus Compounds; D003577:Cytochrome P-450 Enzyme System