title: Fungal resistance.
abstract: Fungal resistance is caused by an acquisition of intrinsically resistant species, by selection of resistant strains from a population or by mutation of an initially susceptible strain. According to different classes of antimycotics there are different resistance mechanisms: differences in the uptake mechanisms, drug target alterations, mostly the ergosterol-biosynthesis pathway, and the efflux or pumping mechanisms to the outside.
authors.affiliation: Universitäts-Klinik für Innere Medizin A, Greifswald, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Bernhardt
authors.forename: K
authors.initials: K
authors.lastname: Zimmermann
authors.forename: M
authors.initials: M
authors.lastname: Knoke
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D006790:Host-Parasite Interactions; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy / Q000453:epidemiology; D012680:Sensitivity and Specificity
chemical_list: D000935:Antifungal Agents