Enoxaparin and bleeding complications: a review in patients with and without renal insufficiency.
OBJECTIVE
To compare the frequency of bleeding complications from enoxaparin in patients with normal renal function versus patients with renal insufficiency.


METHODS
Retrospective chart review.


METHODS
University-based tertiary care center.


METHODS
One hundred six patients who received two or more doses of enoxaparin.


RESULTS
Total bleeding complications occurred in 22% of patients with normal renal function and 51% with renal insufficiency (p<0.01). Major bleeds were also significantly different, 2% and 30%, respectively (p<0.001). No patients with normal renal function were given fresh-frozen plasma or packed red blood cells, whereas in those with renal insufficiency, 13% and 32%, respectively, received these products (p<0.01).


CONCLUSIONS
Enoxaparin may have resulted in increased bleeding complications and use of blood products in patients with renal insufficiency. Prospective studies need to be conducted to define the drug's role and dosage adjustments in these patients.
Gerlach
A T
AT
Department of Pharmacy, Ohio State University Medical Center, Columbus 43210, USA.
Pickworth
K K
KK
Seth
S K
SK
Tanna
S B
SB
Barnes
J F
JF
D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D017984:Enoxaparin / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies
D000925:Anticoagulants; D017984:Enoxaparin