title: Intra-arterial mitoxantrone and paclitaxel in a patient with Stewart-Treves syndrome: selection of chemotherapy by an ex vivo ATP-based chemosensitivity assay.
abstract: We report on a 72-year-old patient developing Stewart-Treves syndrome (STS) of the right arm 9 years after curative irradiation for ipsilateral stage III breast cancer. Facing the poor track record of both irradiation and chemotherapy in this highly malignant lymphangiosarcoma, amputation was recommended but refused by the patient. Therefore, limb conserving-therapy using three courses of intra-arterial mitoxantrone (MX) and paclitaxel (PTX) was attempted. This novel chemotherapy protocol was selected by pretherapeutic ex vivo ATP-based chemosensitivity testing of autologous tumor tissue. The patient experienced complete response, which was subsequent histologically confirmed by compartment resection. When developing recurrent STS outside of the perfused area 6 months after primary therapy, the patient was retested and reinduced with three other courses of intraarterial MX/PTX which again produced durable complete remission. This case demonstrates the benefit of indivdualized therapy in this prognostically desperate disease allowing both limb conservation and maintained quality of life.
authors.affiliation: Department of Gynecology and Obstetrics, University of Cologne, Germany. Martina.Breidenbach@medizin.uni-koeln.de
authors.forename: M
authors.initials: M
authors.lastname: Breidenbach
authors.forename: D
authors.initials: D
authors.lastname: Rein
authors.forename: T
authors.initials: T
authors.lastname: Schmidt
authors.forename: W
authors.initials: W
authors.lastname: Heindel
authors.forename: H
authors.initials: H
authors.lastname: Kolhagen
authors.forename: P
authors.initials: P
authors.lastname: Mallmann
authors.forename: C M
authors.initials: CM
authors.lastname: Kurbacher
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000532:radiotherapy; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008204:Lymphangiosarcoma / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008209:Lymphedema / Q000188:drug therapy / Q000209:etiology; D008942:Mitoxantrone / Q000008:administration & dosage; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D017239:Paclitaxel / Q000008:administration & dosage; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013577:Syndrome
chemical_list: D000255:Adenosine Triphosphate; D008942:Mitoxantrone; D017239:Paclitaxel