title: Expression of DM-GRASP/BEN in the developing mouse spinal cord and various epithelia.
abstract: The expression pattern of the immunoglobulin DM-GRASP/BEN gene was studied in the mouse embryo using in situ hybridization. DM-GRASP/BEN is expressed in the spinal cord in a subset of motoneurons expressing Islet-1, and non homogeneously in the dorsal root ganglia (DRG). In contrast, it's expression is homogeneous in the vestibulo-cochlear and trigemminal ganglia. DM-GRASP/BEN is also expressed in various epithelia of ectodermal or endodermal origin like the nasal, buccopharyngal and lung epithelia. In upper lip, DM-GRASP/BEN transcripts are present in the epidermal cells of the developing hair vibrissa follicles. First detected in the hair placode, DM-GRASP/BEN expression is localized in the central cells of the epithelial hair peg and then in a thin layer of cells crushed against the outer root sheath by the outgrowth of the hair shaft.
authors.affiliation: Biologie de la Différenciation Epithéliale, UMR CNRS 5538 LEDAC, Institut Albert Bonniot, Université Joseph Fourier, Grenoble, France. sandrine.fraboulet@ujf-grenoble.fr
authors.forename: S
authors.initials: S
authors.lastname: Fraboulet
authors.forename: T
authors.initials: T
authors.lastname: Schmidt-Petri
authors.forename: D
authors.initials: D
authors.lastname: Dhouailly
authors.forename: O
authors.initials: O
authors.lastname: Pourquié
mesh_terms: D020410:Activated-Leukocyte Cell Adhesion Molecule / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation; D005314:Embryonic and Fetal Development / Q000235:genetics; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology* / Q000502:physiology*
chemical_list: D020410:Activated-Leukocyte Cell Adhesion Molecule