title: Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder.
abstract: A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:235-239, 2000.
authors.affiliation: Department of Psychiatry, SUNY Stony Brook, Stony Brook, New York 11794, USA. LdeLisi@notes.cc.sunysb.edu
authors.forename: L E
authors.initials: LE
authors.lastname: DeLisi
authors.forename: S
authors.initials: S
authors.lastname: Shaw
authors.forename: T J
authors.initials: TJ
authors.lastname: Crow
authors.forename: G
authors.initials: G
authors.lastname: Shields
authors.forename: A B
authors.initials: AB
authors.lastname: Smith
authors.forename: V W
authors.initials: VW
authors.lastname: Larach
authors.forename: N
authors.initials: N
authors.lastname: Wellman
authors.forename: J
authors.initials: J
authors.lastname: Loftus
authors.forename: B
authors.initials: B
authors.lastname: Nathankumar
authors.forename: K
authors.initials: K
authors.lastname: Razi
authors.forename: M
authors.initials: M
authors.lastname: Kushner
authors.forename: J
authors.initials: J
authors.lastname: Stewart
authors.forename: A
authors.initials: A
authors.lastname: Vita
authors.forename: M
authors.initials: M
authors.lastname: Comazzi
authors.forename: R
authors.initials: R
authors.lastname: Sherrington
mesh_terms: D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D018709:Statistics, Nonparametric
chemical_list: D005819:Genetic Markers