title: Apolipoprotein E and atherosclerosis.
abstract: Apolipoprotein E plays a key protective role in atherosclerosis. Its capacity to safeguard against this disease can be attributed to at least three distinct functions. First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants. Second, lesion apolipoprotein E in concert with apolipoprotein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of the lesion. Third, lesion apolipoprotein E directly modifies both macrophage- and T lymphocyte-mediated immune responses that contribute to this chronic inflammatory disease.
authors.affiliation: The Scripps Research Institute, Department of Immunology, La Jolla, California 92037, USA. lcurtiss@scripps.edu
authors.forename: L K
authors.initials: LK
authors.lastname: Curtiss
authors.forename: W A
authors.initials: WA
authors.lastname: Boisvert
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000502:physiology*; D001161:Arteriosclerosis / Q000503:physiopathology*; D002784:Cholesterol / Q000097:blood; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D002784:Cholesterol