title: Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arterial occlusive disease requiring angioplasty. A possible role in diabetic vascular disease?
abstract: BACKGROUND
  To study levels of E-selectin in patients with peripheral arterial occlusive disease who were undergoing percutaneous transluminal angioplasty.
  
  
  METHODS
  Experimental design and setting: Cross sectional case control study, conducted in a teaching hospital.
  
  
  METHODS
  Seven patients with type-2 (non-insulin dependent) diabetes mellitus undergoing transluminal angioplasty for symptomatic peripheral arterial occlusive disease, had blood tests for sE-selectin measurement, and were compared to a similar groups of age and sex matched non-diabetic patients with arteriopathy who are undergoing the same procedure. Also evaluated were a group of diabetic patients and healthy non-diabetics with no peripheral arterial disease.
  
  
  RESULTS
  The levels of sE-selectin in the two diabetic groups were significantly higher than the non-diabetic groups measuring at 77 ng/ml (53-120) and 79 ng/ml (43-98) (median, range) vs 54 ng/ml (24-104) in the non-diabetic with arteriopathy, and 42 ng/ml (35-66) in the normal healthy controls, p<0.04, p<0.003 respectively, Mann Whitney "U" test.
  
  
  CONCLUSIONS
  We have demonstrated significantly high values of soluble E-selectin in patients with diabetes mellitus requiring angioplasty for symptomatic peripheral arterial occlusive disease. This suggests that sE-selectin may be involved in the diabetic angiopathic process. It may act as a precursor for smooth muscle proliferation.
authors.affiliation: University Department of Medicine, Ninewells Hospital & Medical School, Dundee Scotland, UK.
authors.forename: T A
authors.initials: TA
authors.lastname: Elhadd
authors.forename: G
authors.initials: G
authors.lastname: Kennedy
authors.forename: M
authors.initials: M
authors.lastname: McLaren
authors.forename: P A
authors.initials: PA
authors.lastname: Stonebridge
authors.forename: W J
authors.initials: WJ
authors.lastname: Shaw
authors.forename: J J
authors.initials: JJ
authors.lastname: Belch
mesh_terms: D000800:Angioplasty, Balloon; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003925:Diabetic Angiopathies / Q000097:blood* / Q000628:therapy*; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000097:blood* / Q000209:etiology / Q000628:therapy*
chemical_list: D019040:E-Selectin