title: Hodgkin's disease in association with Down syndrome: a case report.
abstract: The increased incidence of malignancies, especially acute leukemia, in Down syndrome has been clearly established. The association of Hodgkin's disease with Down syndrome has not been extensively documented, and only a few cases have been reported. We present here a case report of Hodgkin's disease in an 11-year-old female child with Down syndrome. The child presented with a stage IVB nodular sclerotic Hodgkin's disease and died of progressive disease. We also present a brief review of the mechanisms of development of malignancy in Down syndrome.
authors.affiliation: Regional Cancer Centre, Trivandrum, Kerala, India.
authors.forename: P
authors.initials: P
authors.lastname: Kusumakumary
authors.forename: R
authors.initials: R
authors.lastname: Jyothirmayi
authors.forename: V G
authors.initials: VG
authors.lastname: Chellam
authors.forename: N M
authors.initials: NM
authors.lastname: Krishnan
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002648:Child; D004314:Down Syndrome / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D020022:Genetic Predisposition to Disease; D006689:Hodgkin Disease / Q000150:complications* / Q000235:genetics; D006801:Humans; D016312:Treatment Refusal