[Treatment of unspecific ulcerative rectocolitis in a child with enemas containing butyrate. Case report].
OBJECTIVE
To report a promising therapy to ulcerative colitis in children.


METHODS
We report a case of ulcerative colitis in 4 years old female, who had this diagnosis since she was 1 year old. The treatment of RCU1 had an unsatisfactory response to conventional therapies (rectal and oral corticosteroids and immunosuppressive agent).


RESULTS
She showed improvement, using enemas containing butyrate, in clinical, endoscopic and histological parameters.


CONCLUSIONS
Although the role of butyrate in the treatment of ulcerative colitis still remains to be determined, we find effective response in this case. Despite evidences that butyrate may be beneficial and safety in treating refractory distal ulcerative colitis, results of controlled trials, specially in children will be necessary to prove the efficacy of this therapy.
Assumpção
I R
IR
Unidade da Gastroenterologia do Instituto da Criança, Hospital da Clínicas da Faculdade de Medicina, Universidade de São Paulo-ICr-HC-FMUSP. izaura@u-net.com.br
Rodrigues
M
M
Barbieri
D
D
D000284:Administration, Oral; D000285:Administration, Rectal; D002087:Butyrates / Q000008:administration & dosage / Q000627:therapeutic use*; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D004733:Enema / Q000379:methods*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D015122:Mercaptopurine / Q000008:administration & dosage / Q000627:therapeutic use
D002087:Butyrates; D007166:Immunosuppressive Agents; D015122:Mercaptopurine