[An experimental study of the role of a blockade of serotonin 5-HT3 receptors and dopamine D2 receptors in the mechanism of the occurrence of early radiation vomiting in monkeys].
The experiments with M. fasciculata monkeys exposed to 137Cs gamma-radiation with a dose of 6.9 Gy showed that Latranum, a blocker of serotonin 5-HT3 receptors, is a more efficient antiemetic than Dimetphramidum, a D2 dophamin lytic. This is suggested by fewer animals with emetic reaction of by less severe vomiting in case they have any. The results agree well with a hypothesis that serotonin receptors are dominant in the chemoreceptor trigger zone of monkeys.
Martirosov
K S
KS
State Research Center of Russia, Institute of Biophysics, Moscow. ibkoguc@alara.msk.su
Grigor'ev
Iu G
IuG
Zorin
V V
VV
Andrianova
I E
IE
D000818:Animals; D000932:Antiemetics / Q000494:pharmacology* / Q000627:therapeutic use; D001549:Benzamides / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D065127:Dopamine D2 Receptor Antagonists; D004353:Drug Evaluation, Preclinical; D005260:Female; D005720:Gamma Rays; D008252:Macaca fascicularis; D008297:Male; D011833:Radiation Injuries, Experimental / Q000150:complications* / Q000188:drug therapy; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000528:radiation effects; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000528:radiation effects; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors; D014839:Vomiting / Q000188:drug therapy / Q000209:etiology*; D014916:Whole-Body Irradiation
D000932:Antiemetics; D001549:Benzamides; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists; C037141:dimetpramid