title: Nonpsychotropic synthetic cannabinoids.
abstract: Unlike natural cannabinoids which belong to the 6aR - trans series, the synthetic dexanabinol (HU-211), a 6aS-trans enantiomer, does not have affinity toward cannabinoid receptors and is devoid of cannabimimetic activity. On the other hand, dexanabinol demonstrated significant neuroprotective properties which prompted its development as a therapeutic agent. We now present the extension of a series of 6aS-trans cannabinoids with novel derivatives, including water soluble derivatives and congeners of dexanabinol.
authors.affiliation: Alchem Laboratories Corporation, 13305 Rachael Boulevard, Alachua, FL, USA. emilpop@aol.com
authors.forename: E
authors.initials: E
authors.lastname: Pop
mesh_terms: D000818:Animals; D002186:Cannabinoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000187:drug effects
chemical_list: D002186:Cannabinoids; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug