STAM2, a new member of the STAM family, binding to the Janus kinases.
We here cloned a cDNA encoding STAM2, a new member of the STAM family, which contains an SH3 domain and ITAM. STAM2 like STAM1 is associated with Jak2 and Jak3, and involved in the signaling for DNA synthesis and c-myc induction mediated by IL-2 and GM-CSF. Co-expression of the SH3 deletion mutants of STAM1 and STAM2 induces an additive effect on suppressing DNA synthesis upon stimulation with IL-2 and GM-CSF, suggesting that STAM1 and STAM2 exhibit compensatory effects on the signaling pathways downstream of Jak2 and Jak3 upon stimulation with GM-SCF and IL-2, respectively.
Endo
K
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Department of Microbiology, Tohoku University School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai 980-8575, Japan.
Takeshita
T
T
Kasai
H
H
Sasaki
Y
Y
Tanaka
N
N
Asao
H
H
Kikuchi
K
K
Yamada
M
M
Chenb
M
M
O'Shea
J J
JJ
Sugamura
K
K
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000096:biosynthesis; D056827:Endosomal Sorting Complexes Required for Transport; D020869:Gene Expression Profiling; D005799:Genes, Dominant / Q000235:genetics; D016259:Genes, myc / Q000235:genetics; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D053614:Janus Kinase 2; D053616:Janus Kinase 3; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D010750:Phosphoproteins / Q000737:chemistry* / Q000235:genetics; D010766:Phosphorylation / Q000187:drug effects; D019000:Phosphotyrosine / Q000378:metabolism; D011485:Protein Binding; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins; D017384:Sequence Deletion / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects; D013379:Substrate Specificity; D015533:Transcriptional Activation / Q000187:drug effects; D018909:src Homology Domains
D048868:Adaptor Proteins, Signal Transducing; D056827:Endosomal Sorting Complexes Required for Transport; D006133:Growth Substances; D007376:Interleukin-2; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; C109775:STAM protein, human; C491647:STAM2 protein, human; D019000:Phosphotyrosine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D004247:DNA; D011505:Protein-Tyrosine Kinases; C507924:JAK2 protein, human; C507933:JAK3 protein, human; D053614:Janus Kinase 2; D053616:Janus Kinase 3