title: Synthesis and herbicidal activity of N-oxide derivatives.
abstract: As part of an ongoing program on the chemistry and biological activity of N-oxide-containing molecules, a number of novel 1,2, 5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline N,N'-dioxide derivatives were synthesized and evaluated for their herbicidal activity. Many of these compounds exhibited moderate to good herbicidal pre-emergence activity against Triticum aestivum. Dose-response studies were done on the more representative compounds (12, 20, and 26). The most active compound, butylcarbamoylbenzo[1,2-c]1,2,5-oxadiazole N-oxide, 26, displayed herbicidal activity at concentrations as low as 24 g/ha.
authors.affiliation: Cátedra de Cereales y Cultivos Industriales, Facultad de Agronomía, Universidad de la República, Paysandú, Uruguay. hcerecet@bilbio.edu.uy
authors.forename: H
authors.initials: H
authors.lastname: Cerecetto
authors.forename: E
authors.initials: E
authors.lastname: Dias
authors.forename: R
authors.initials: R
authors.lastname: Di Maio
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: S
authors.initials: S
authors.lastname: Pacce
authors.forename: P
authors.initials: P
authors.lastname: Saenz
authors.forename: G
authors.initials: G
authors.lastname: Seoane
authors.forename: L
authors.initials: L
authors.lastname: Suescun
authors.forename: A
authors.initials: A
authors.lastname: Mombrú
authors.forename: G
authors.initials: G
authors.lastname: Fernández
authors.forename: M
authors.initials: M
authors.lastname: Lema
authors.forename: J
authors.initials: J
authors.lastname: Villalba
mesh_terms: D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000138:chemical synthesis* / Q000494:pharmacology; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D010087:Oxides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D006540:Herbicides; D010087:Oxides