title: Effect of interposed periosteum in an animal physeal fracture model.
abstract: To study the effect of interposed periosteum on physeal fracture healing, 52 skeletally immature female Harlan Sprague-Dawley rats, 4 to 5 weeks of age, were randomized to one of three cohort groups. All animals underwent surgical dissection of the left proximal medial tibia; dissection consisted of superficial exposure and incision of a standard periosteal flap. Animals in Group I (fracture alone) underwent physeal fracture; those in Group II (fracture and periosteum) underwent physeal fracture with interposition of periosteum in the fracture site, and those in Group III (positive control) underwent physeal fracture, excision of 1/2 of the growth plate, and interposition of periosteum in the defect. After histologic examination of serial sections, fracture alone resulted in physeal injury frequently associated with small bar formation without a reduction in leg length. With the addition of interposition of periosteum into the fracture site, a small, but statistically significant, increase in leg length discrepancy frequently associated with small histologic bar formation occurred when compared with fracture alone.
authors.affiliation: Carolinas Medical Center, Charlotte, NC, USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Phieffer
authors.forename: R A
authors.initials: RA
authors.lastname: Meyer
authors.forename: H E
authors.initials: HE
authors.lastname: Gruber
authors.forename: M
authors.initials: M
authors.lastname: Easley
authors.forename: J M
authors.initials: JM
authors.lastname: Wattenbarger
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005260:Female; D017102:Fracture Healing; D006132:Growth Plate; D007870:Leg Length Inequality / Q000209:etiology; D010521:Periosteum; D010865:Pilot Projects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013978:Tibial Fractures / Q000601:surgery*