Primary lumbosacral Wilms tumour associated with occult spinal dysraphism.
A 4-year-old child presenting with sudden-onset paraplegia and a sacral tumour in association with spina bifida occulta is reported. There were no stigmata of spinal dysraphism at birth. Imaging studies confirmed a sacral tumour with extradural extension up to T10 and spinal dysraphism. The histological features of the extradural and sacral components of the tumour were consistent with a Wilms tumour. The differential diagnosis included a primary sacral teratoma containing Wilms tumour elements or a primary extrarenal Wilms tumour arising in association with a spinal dysraphism. There was no clinical response to chemotherapy or radiotherapy.
Govender
D
D
Department of Pathology, University of Natal Medical School, Durban, South Africa. govendh@med.und.ac.za
Hadley
G P
GP
Nadvi
S S
SS
Donnellan
R B
RB
D002675:Child, Preschool; D005260:Female; D006801:Humans; D012447:Sacrum / Q000473:pathology* / Q000601:surgery; D016135:Spinal Dysraphism / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013125:Spinal Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013724:Teratoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D009396:Wilms Tumor / Q000150:complications / Q000473:pathology* / Q000601:surgery