Characterization of a novel respiratory syncytial virus-specific human cytotoxic T-lymphocyte epitope.
Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8(+) T cells.
Goulder
P J
PJ
Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. goulder@helix.mgh.harvard.edu
Lechner
F
F
Klenerman
P
P
McIntosh
K
K
Walker
B D
BD
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D018984:Epitopes, T-Lymphocyte; D005434:Flow Cytometry; D015793:HLA-B7 Antigen / Q000378:metabolism; D006801:Humans; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D015793:HLA-B7 Antigen