Reduction in incidence of severe paracetamol poisoning.
We report substantial reductions in the frequency of severe paracetamol hepatotoxicity locally and nationally after legislative limitations on its sale. These reductions were not explained by changes in referral patterns or use of N-acetylcysteine.
Prince
M I
MI
Thomas
S H
SH
James
O F
OF
Hudson
M
M
D000082:Acetaminophen / Q000506:poisoning*; D000111:Acetylcysteine / Q000008:administration & dosage; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D007880:Legislation, Drug; D008107:Liver Diseases / Q000628:therapy; D008297:Male; D011041:Poisoning / Q000145:classification / Q000453:epidemiology / Q000517:prevention & control; D012720:Severity of Illness Index; D006113:United Kingdom / Q000453:epidemiology
D018712:Analgesics, Non-Narcotic; D016166:Free Radical Scavengers; D000082:Acetaminophen; D000111:Acetylcysteine