Synthesis of [bis(inosine-5')]-tetraphosphate and [bis(inosine-5')]-pentaphosphate analogues bearing the residues of methylenediphosphonic acid.
Various methods of synthesis of metabolically stable phosphonate analogues of bisnucleoside oligophosphates containing two residues of methylenediphosphonic acid in the oligophosphate chain are studied. Phosphonate analogues of Ip4I and Ip5I are prepared.
Shipitsyn
A V
AV
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
Tarussova
N B
NB
Shirokova
E A
EA
Krayevsky
A A
AA
D007292:Inosine Nucleotides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D063065:Organophosphonates / Q000138:chemical synthesis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet
D007292:Inosine Nucleotides; D063065:Organophosphonates; C414828:bis(inosine-5')-pentaphosphate; C414829:bis(inosine-5')-tetraphosphate