[Expression of heat shock proteins in salivary gland tumors. Immunohistochemical study of HSP27, HSP70, HSP90, and HSP110: apropos of 50 cases].
Heat shock proteins (HSPs) are known to be increased in response to biological stress. Recently some authors described their presence in tumors. Our immunohistochemical investigations revealed the expression of HSP27, HSP70, HSP90 and HSP110 in most of benign tumors of salivary glands (33 cases). In the malignant tumors, the reaction was immunopositive for HSP70 and HSP90 in 13/17 cases; but HSP27 and HSP110 were only expressed in 5/17 cases. In conclusion HSPs were expressed less in malignant than in benign cells. These results suggest that the loss of some HSPs may be a possible sign of malignancy.
Vanmuylder
N
N
Laboratoire d'Anatomie Pathologique et de Microscopie Electronique, Université Libre de Bruxelles, route de Lennik, 1070 Bruxelles.
Evrard
L
L
Daelemans
P
P
Van Reck
J
J
Dourov
N
N
D050957:HSP110 Heat-Shock Proteins; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000032:analysis*; D018841:HSP90 Heat-Shock Proteins / Q000032:analysis*; D006360:Heat-Shock Proteins; D006801:Humans; D007124:Immunoenzyme Techniques; D018832:Molecular Chaperones; D009363:Neoplasm Proteins / Q000032:analysis*; D012468:Salivary Gland Neoplasms / Q000737:chemistry*
D050957:HSP110 Heat-Shock Proteins; D055551:HSP27 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins; C057725:HSPB1 protein, human; C097205:HSPH1 protein, human; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D009363:Neoplasm Proteins