Evolutionary conservation of gene structures of the Pax1/9 gene family.
Based on amino acid sequence comparisons, Pax1 and Pax9 genes are considered to form a subgroup of vertebrate Pax genes. We show here that the gene structures of mouse Pax1, human PAX9 genes are similar to that of a single Pax1/9 related gene in Branchiostoma lanceolatum, AmphiPax1. This supports the hypothesis that Pax1 and Pax9 genes were derived from a single ancestral gene. A refined protein alignment of AmphiPax1, mouse Pax1 and human PAX9 proteins based on the determined exon boundaries indicates that sequence divergence at the C-termini may be related to the unique functions of the Pax1 and Pax9 genes in vertebrates. AmphiPax1 is expressed in adult amphioxus in the pharyngeal endoderm.
Hetzer-Egger
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C
Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, Stuebeweg 51, D-79108, Freiburg, Germany.
Schorpp
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M
Boehm
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T
D000595:Amino Acid Sequence; D000818:Animals; D002816:Chordata, Nonvertebrate / Q000235:genetics*; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000235:genetics; D019143:Evolution, Molecular; D016678:Genome; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D051764:PAX9 Transcription Factor; D051761:Paired Box Transcription Factors; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D051764:PAX9 Transcription Factor; C497323:PAX9 protein, human; D051761:Paired Box Transcription Factors; D014157:Transcription Factors; C119756:pax19 protein, invertebrate; C070835:PAX1 transcription factor