Isoproterenol-induced myocardial injury resulting in altered S100A4 and S100A11 protein expression in the rat.
S-100 proteins (S100) are characterized by calcium-binding ability with two structural EF hands. Several S100 are expressed in cardiomyocytes and thought to play a crucial role in calcium signaling. To examine whether the expression of S100 is a response to detectable myocardial damage or regeneration, we investigated, immunohistochemically, the expression of S100A4 and S100A11 in the isoproterenol (ISP)-treated rat heart. Definite expression of S100A4 and S100A11 was demonstrated in normal cardiomyocytes, and their staining patterns were enhanced in the ISP-treated rat heart, suggesting the possible involvement of S1-A4 and S100A11 in ISP-induced myocardial damage.
Inamoto
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S
The Second Department of Pathology, andThe First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan.
Murao
S
S
Yokoyama
M
M
Kitazawa
S
S
Maeda
S
S
D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D006332:Cardiomegaly / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D006352:Heart Ventricles / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007150:Immunohistochemistry; D007545:Isoproterenol / Q000009:adverse effects*; D008297:Male; D008969:Molecular Sequence Data; D009206:Myocardium / Q000737:chemistry / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D007106:Immune Sera; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; C499412:S100a4 protein, rat; C077591:S100A4 protein, human; C072337:S100A11 protein, human; D007545:Isoproterenol