title: Fractionated stereotactic radiotherapy for pediatric brain tumors: the Chicago children's experience.
abstract: Thirty-three children with a total of 35 benign/malignant brain and eye neoplasms were treated with fractionated stereotactic radiotherapy. In the first 11 children immobilization for treatment was achieved with plaster of Paris casts or aquaplast masks. In the remaining 22 children the Laitinen stereoadapter was used. Radiation was delivered with noncoplanar static or rotational beams. The dose fractionation used was 50.4-60 Gy in 28-30 fractions in patients receiving treatment with curative intent, and 10-32 Gy at 2-4 Gy/fraction for reirradiation. The accuracy of daily treatment was < 2 mm. After a median follow-up of 27 months, 22 of the 25 children treated with curative intent achieved local control. One child had progressive brain necrosis following 54 Gy in 30 fractions for a pontine astrocytoma. The exact etiology of this complication is unknown. This series demonstrates that in children fractionated stereotactic radiotherapy using the Laitinen stereoadapter is well tolerated and accurate and results in good local control.
authors.affiliation: Division of Radiation Oncology, Northwestern Memorial Hospital, Chicago, Illinois, USA. j-kalapurakal@nwu.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Kalapurakal
authors.forename: A
authors.initials: A
authors.lastname: Kepka
authors.forename: T
authors.initials: T
authors.lastname: Bista
authors.forename: S
authors.initials: S
authors.lastname: Goldman
authors.forename: T
authors.initials: T
authors.lastname: Tomita
authors.forename: M H
authors.initials: MH
authors.lastname: Marymont
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000532:radiotherapy*; D002641:Chicago; D002648:Child; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000379:methods*; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D005134:Eye Neoplasms / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D012189:Retrospective Studies; D013238:Stereotaxic Techniques; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome