title: New antineoplastic prenylhydroquinones. Synthesis and evaluation.
abstract: Several prenylhydroquinones have been prepared through Diels-Alder condensation, further functionalized or degraded chemically and then evaluated for their cytotoxic activity against some neoplastic cultured cell lines. A number of them have shown IC50 values under the microM level.
authors.affiliation: Instituto de Química, Universidad Católica de Valparaíso, Chile.
authors.forename: A
authors.initials: A
authors.lastname: Molinari
authors.forename: A
authors.initials: A
authors.lastname: Oliva
authors.forename: N
authors.initials: N
authors.lastname: Aguilera
authors.forename: J M
authors.initials: JM
authors.lastname: Miguel del Corral
authors.forename: M A
authors.initials: MA
authors.lastname: Castro
authors.forename: M
authors.initials: M
authors.lastname: Gordaliza
authors.forename: M D
authors.initials: MD
authors.lastname: García-Grávalos
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006873:Hydroquinones