A cutaneous eruption from G-CSF in a healthy donor.
A healthy 12-month-old donor treated with G-CSF for collection of stem cells from peripheral blood developed a discrete, papular, erythematous eruption which histologically showed irregularly shaped lymphocytes with mitoses. We suggest that such a reaction is due to activation of lymphocytes by G-CSF in a normal host, leading to atypical changes in cellularity.
Torrelo
A
A
Departments of Pediatric Dermatology, Hospital del Niño Jesús, Madrid, Spain.
Madero
L
L
Mediero
I G
IG
Zambrano
A
A
D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007223:Infant; D008297:Male; D012871:Skin Diseases / Q000209:etiology*; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000009:adverse effects*
D016179:Granulocyte Colony-Stimulating Factor