title: [The synthetic peptide D-(iEW) (thymodepressin) protects bone marrow CFU-S from ionizing radiation exposure].
abstract: Synthetic polypeptide D-(iEW) (Thymodepressin) was shown to reduce the bone marrow CFU-S in the S-phase of cell cycle. Apparently, due to this property the agent being administered 2 days before the irradiation with 4 Gy causes a prominent restoration of the CFU-S population afterwards. The 3-5 times higher value of this parameter as compared to the control (irradiation only) is likely to be connected to the increased "survival" of the Thymodepressin-protected CFU-S after the treatment with ionizing irradiation.
authors.affiliation: Medical Radiological Research Centre, Russian Academy of Medical Sciences, Obninsk, Russia. mrrc@obninsk.ru
authors.forename: O V
authors.initials: OV
authors.lastname: Semina
authors.forename: V I
authors.initials: VI
authors.lastname: Deĭgin
authors.forename: T N
authors.initials: TN
authors.lastname: Semenets
authors.forename: G P
authors.initials: GP
authors.lastname: Beziaev
authors.forename: A M
authors.initials: AM
authors.lastname: Poverennyĭ
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D003114:Colony-Forming Units Assay; D005260:Female; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D013997:Time Factors
chemical_list: D010455:Peptides; D011837:Radiation-Protective Agents