title: Enhanced oncogenicity of human papillomavirus type 16 (HPV16) variants in Japanese population.
abstract: To investigate whether HPV16 E6 variants carry an elevated risk for cervical cancer in Japanese population, we investigated the E6 sequence variation in 40 cervical intraepithelial neoplasias (CINs) I-III and 43 invasive cervical cancers (ICCs), all positive for HPV16. HPV16 E6 variants were frequently found in ICCs than in CINs (88 vs. 65%, P=0.01). The E6 D25E, a rare variant in Western countries, was most frequently observed in ICC (44%). CIN I/II lesions with HPV16 variants were less likely to regress than those with HPV16 prototype (P=0.048). The finding that HPV16 E6 variants represent a significant risk factor is common between Western and Japanese women despite the different distribution of each variant.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tokyo, 1-7-1, Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Nakagawa
authors.forename: X
authors.initials: X
authors.lastname: Tang
authors.forename: T
authors.initials: T
authors.lastname: Yasugi
authors.forename: K
authors.initials: K
authors.lastname: Kawana
authors.forename: S
authors.initials: S
authors.lastname: Sekiya
authors.forename: Y
authors.initials: Y
authors.lastname: Hirai
authors.forename: I
authors.initials: I
authors.lastname: Kukimoto
authors.forename: T
authors.initials: T
authors.lastname: Kanda
authors.forename: Y
authors.initials: Y
authors.lastname: Taketani
mesh_terms: D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology; D012097:Repressor Proteins; D012307:Risk Factors; D012689:Sequence Homology, Nucleic Acid; D014412:Tumor Virus Infections / Q000150:complications / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000821:virology*
chemical_list: D004279:DNA, Viral; C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins