title: Pigmented nails and Strongyloides stercoralis infestation causing clinical worsening in a patient treated for immunoproliferative small intestinal disease: two unusual observations.
abstract: Immunoproliferative small intestinal disease (IPSID) is commonly reported from developing countries with poor socioeconomic conditions, hygiene, and high frequency of gastrointestinal infections and infestations. The disease requires anti-malignant chemotherapy in lymphomatous stage. Reported here is a 20-year old man with IPSID lymphoma who responded to anti-malignant chemotherapy initially, but later deteriorated due to Strongyloides stercoralis infestation, which was treated successfully with mebendazole. Importance of an early recognition and adequate treatment for gastrointestinal infections and infestations before anti-malignant chemotherapy for this disease is highlighted considering the occurrence of this disease in the developing world. The patient developed alternate brown black and white lines in the finger nails after combination chemotherapy, which has not been reported earlier in this disease; the nail changes disappeared 6 months after the withdrawal of doxorubicin suggesting this drug as the cause for such nail changes during anti-malignant combination chemotherapy.
authors.affiliation: Department of Gastroenterology, Institute of Postgraduate Medical Education and Research, Calcutta, India. shanti@cal2.vsnl.net.in
authors.forename: U C
authors.initials: UC
authors.lastname: Ghoshal
authors.forename: J
authors.initials: J
authors.lastname: Saha
authors.forename: U
authors.initials: U
authors.lastname: Ghoshal
authors.forename: B K
authors.initials: BK
authors.lastname: Ray
authors.forename: A
authors.initials: A
authors.lastname: Santra
authors.forename: S
authors.initials: S
authors.lastname: Naik
authors.forename: D N
authors.initials: DN
authors.lastname: Mazumder
mesh_terms: D000328:Adult; D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D006801:Humans; D007161:Immunoproliferative Small Intestinal Disease / Q000150:complications* / Q000188:drug therapy; D007414:Intestinal Neoplasms / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D009262:Nails / Q000187:drug effects* / Q000473:pathology; D017171:Strongyloides stercoralis; D013322:Strongyloidiasis / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology
chemical_list: D000969:Antinematodal Agents; D008463:Mebendazole