Expression of vascular endothelial growth factor in liver tissues of hepatitis B.
OBJECTIVE
To study the relationship between vascular endothelial growth factor (VEGF) and grading (G) and staging (S) of hepatitis B (HB).


METHODS
Immunohistochemical staining was performed with VEGF monoclonal antibody in 250 biopsies of HB.


RESULTS
The types of VEGF expression in liver tissues were of plasma type, sinusoidal membrane type and sinusoidal endothelial cell type. VEGF was mainly secreted by hepatocytes, and was also positively expressed in liver sinusoidal endothelial cells, fat-storing cells, myofibroblast and monomorphological nuclear cells. And it was negative in vascular endothelial cells and hepatocytes which had not significant damage, suggesting that the expression of VEGF was enhanced with the increase of G (chi(2)=90.43, P<0.01). VEGF was positively expressed on those whose scores of S were lower, while strongly positively expressed on those whose scores of S were higher. There was also a significant difference between them (chi(2)=115.74, P<0.01).


CONCLUSIONS
The expressions of VEGF are related to G and S of HB
Yan
J
J
Department of Pathology, 123rd Hospital of PLA, Bengbu, Anhui Province 233015, China.
Chen
W
W
Ma
Y
Y
Sun
X
X
D016228:Endothelial Growth Factors / Q000032:analysis*; D019694:Hepatitis B, Chronic / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry*; D008222:Lymphokines / Q000032:analysis*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors