title: Identification of a novel HLA-B46 allele, B*4602, in Japanese.
abstract: The B*4602 was identified in a healthy Japanese donor. The B46 variant antigen differed serologically from B46. The nucleotide sequence of B*4602 differed from that of B*4601 by a single base (from A to G) at position 293 in exon 2. The substitution changed the amino acid Asp at position 74 to Gly. The gene frequency of B*4602 in the Japanese population is extremely low. The presumed haplotype of B*4602 was HLA-A2-Cw1-B*4602-DRB1*09. This is the first report of polymorphism of the B46 antigen.
authors.affiliation: Japanese Red Cross Central Blood Center, Hoshi University, Tokyo.
authors.forename: T
authors.initials: T
authors.lastname: Akesaka
authors.forename: K
authors.initials: K
authors.lastname: Kashiwase
authors.forename: M
authors.initials: M
authors.lastname: Shimamura
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Fujii
authors.forename: T
authors.initials: T
authors.lastname: Akaza
authors.forename: K
authors.initials: K
authors.lastname: Hando
authors.forename: S
authors.initials: S
authors.lastname: Yuasa
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Juji
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D005091:Exons; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D014019:Tissue Donors
chemical_list: D015235:HLA-B Antigens; C080311:HLA-B46 antigen