Serum alpha-fetoprotein levels in Beckwith-Wiedemann syndrome.
We conducted a retrospective study that compared serial alpha-fetoprotein (AFP) concentrations obtained from 22 children with Beckwith-Wiedemann syndrome (BWS) with levels established for healthy children. The AFP concentration is greater in patients with BWS and declines during the postnatal period at a significantly slower rate than what is reported in healthy children. AFP levels obtained in the course of routine tumor screening in children with BWS should be interpreted with a normal curve established specifically for BWS rather than with previously published data for healthy infants and children.
Everman
D B
DB
Department of Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, OH 44106-6506, USA.
Shuman
C
C
Dzolganovski
B
B
O'riordan
M A
MA
Weksberg
R
R
Robin
N H
NH
D001506:Beckwith-Wiedemann Syndrome / Q000097:blood*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins