Formulation and evaluation of Methocel K15M bioadhesive matrix tablets.
Methocel K15M is a bioadhesive polymer. Its adhesion and bioadhesion characteristics were evaluated by shear stress measurement and detachment force measurement methods, respectively. The effect of pH on adhesion was studied, and it was found that the maximum adhesion was between pH 5 and pH 6. Adhesion strength at different parts of the sheep intestine was studied; in the duodenal portion of the intestine, the adhesion was maximum. Chlorpheniramine maleate and diclofenac sodium drugs are formulated with Methocel K15M as matrix tablets. In vitro release studies revealed that some of the formulations showed initial first-order behavior followed by zero-order release behavior.
Chary
R B
RB
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Rao
Y M
YM
D000269:Adhesives / Q000493:pharmacokinetics*; D000818:Animals; D002744:Chlorpheniramine / Q000493:pharmacokinetics*; D006634:Histamine H1 Antagonists / Q000493:pharmacokinetics*; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000378:metabolism*; D008747:Methylcellulose / Q000493:pharmacokinetics*; D011108:Polymers / Q000493:pharmacokinetics; D012756:Sheep; D013607:Tablets
D000269:Adhesives; D006634:Histamine H1 Antagonists; D011108:Polymers; D013607:Tablets; D002744:Chlorpheniramine; D008747:Methylcellulose