title: Haptoglobin phenotypes in HIV-1-seropositive patients in Ghana: decreased risk for Hp0 individuals.
abstract: Plasma haptoglobin phenotypes were determined by polyacrylamide gel electrophoresis, followed by benzidine staining for 58 HIV-1 seropositive Ghanaians and 79 randomly selected age-matched controls. Hp0 was present in only 14% of HIV-1 seropositive individuals compared with more than 40% of the controls. The Hp0 individuals showed a highly significant reduced risk for HIV-1 infection (OR = 0. 21, 95% CI = 0.09-0.51, p = 0.0002). Hp0 may have a protective effect in HIV-1 infection.
authors.affiliation: Noguchi Memorial Institute for Medical Research University of Ghana, Legon, Accra, Ghana. noguchi@ncs.com.gh
authors.forename: I K
authors.initials: IK
authors.lastname: Quaye
authors.forename: F A
authors.initials: FA
authors.lastname: Ekuban
authors.forename: J A
authors.initials: JA
authors.lastname: Brandful
authors.forename: B A
authors.initials: BA
authors.lastname: Gyan
authors.forename: B D
authors.initials: BD
authors.lastname: Akanmori
authors.forename: N A
authors.initials: NA
authors.lastname: Ankrah
mesh_terms: D004591:Electrophoresis, Polyacrylamide Gel; D005869:Ghana; D006679:HIV Seropositivity / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000302:isolation & purification; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D010641:Phenotype
chemical_list: D006242:Haptoglobins