title: Initial interactions of subgenus D adenoviruses with A549 cellular receptors: sialic acid versus alpha(v) integrins.
abstract: Selected members of the adenovirus family have been shown to interact with the coxsackie adenovirus receptor, alpha(v) integrins, and sialic acid on target cells. Initial interactions of subgenus D adenoviruses with target cells have until now been poorly characterized. Here, we demonstrate that adenovirus type 8 (Ad8), Ad19a, and Ad37 use sialic acid as a functional cellular receptor, whereas the Ad9 and Ad19 prototypes do not.
authors.affiliation: Department of Virology, University of Umeâ, S-90185 Umeâ, Sweden. niklas.arnberg@climi.umu.se
authors.forename: N
authors.initials: N
authors.lastname: Arnberg
authors.forename: A H
authors.initials: AH
authors.lastname: Kidd
authors.forename: K
authors.initials: K
authors.lastname: Edlund
authors.forename: F
authors.initials: F
authors.lastname: Olfat
authors.forename: G
authors.initials: G
authors.lastname: Wadell
mesh_terms: D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000378:metabolism*; D002213:Capsid / Q000737:chemistry / Q000235:genetics; D036022:Capsid Proteins; D029822:Enterovirus B, Human / Q000378:metabolism; D006801:Humans; D039564:Integrin alphaV; D008969:Molecular Sequence Data; D019158:N-Acetylneuraminic Acid / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D015703:Antigens, CD; D036022:Capsid Proteins; D039564:Integrin alphaV; D011991:Receptors, Virus; C043322:penton protein, adenovirus; D019158:N-Acetylneuraminic Acid