title: Heart failure with preserved LV function: pathophysiology, clinical presentation, treatment, and nursing implications.
abstract: The syndrome of congestive heart failure occurring secondary to diastolic dysfunction accounts for the major pathophysiologic mechanism in up to one-third of patients who present with dyspnea on exertion and pulmonary congestion. Diastolic dysfunction is characterized by an alteration in the normal diastolic pressure-volume relationship while systolic function may be normal. It is manifested by impairment in the left ventricle's ability to relax and fill completely during diastole at normal low ventricular pressures. This subset of heart failure is most commonly associated with concentric left ventricular hypertrophy and ischemic states. Symptom presentation is similar to that associated with systolic dysfunction as are rates of rehospitalization. Diagnosis is made based on data obtained from invasive and noninvasive procedures. Unlike in the setting of systolic dysfunction, however, there are no large-scale randomized clinical trials evaluating drug efficacy that could be used to guide treatment for the management of diastolic dysfunction. Treatment recommendations, therefore, are empiric. Identifying and aggressively treating potentially reversible causes is a priority. Many of the same drugs used in the management of heart failure associated with systolic dysfunction are also used in the setting of diastolic impairment; however, dosages and rationale for administration may differ. Nursing interventions too are similar. Monitoring response to medications, especially in the acute setting, and comprehensive patient education are paramount. Much is yet to be learned about the management of diastolic dysfunction.
authors.affiliation: Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri, USA.
authors.forename: S
authors.initials: S
authors.lastname: Beattie
mesh_terms: D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003971:Diastole; D006333:Heart Failure / Q000188:drug therapy / Q000451:nursing / Q000503:physiopathology; D006801:Humans; D016277:Ventricular Function, Left
chemical_list: D002317:Cardiovascular Agents