title: Synthesis and antitumor activity of selected 7-alkylidene substituted cephems.
abstract: Selected 7-alkylidene substituted cephems were synthesized and subjected to antitumor assay. The effect of substituents was examined to establish structure-activity relationships. It was found that the intensive intracellular generation of nitric oxide induced by tert-butyl 7-alkylidene cephalosporanate sulfones could be also regarded as an additional cytotoxic factor taking place both in vitro and in vivo experiments.
authors.affiliation: Latvian Institute of Organic Synthesis, Riga, Latvia. veinberg@osi.lanet.lv
authors.forename: G
authors.initials: G
authors.lastname: Veinberg
authors.forename: M
authors.initials: M
authors.lastname: Vorona
authors.forename: I
authors.initials: I
authors.lastname: Shestakova
authors.forename: I
authors.initials: I
authors.lastname: Kanepe
authors.forename: O
authors.initials: O
authors.lastname: Zharkova
authors.forename: R
authors.initials: R
authors.lastname: Mezapuke
authors.forename: I
authors.initials: I
authors.lastname: Turovskis
authors.forename: I
authors.initials: I
authors.lastname: Kalvinsh
authors.forename: E
authors.initials: E
authors.lastname: Lukevics
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002511:Cephalosporins