The Q/E27 polymorphism in the beta2-adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride-rich lipoproteins.
OBJECTIVE
To investigate whether a substitution of glutamine by glutamic acid at amino acid position 27 (Q/E27) and an arginine to glycine transition at amino acid 16 (R/G16) in the beta2-adrenoceptor gene are associated with lipid and lipoprotein disturbances and/or increased body weight in men.


METHODS
Population-based study.


METHODS
Department of medicine at a university hospital.


METHODS
A total of 180 healthy men, aged 30-45 years, were recruited at random from a register containing all permanent residents in Stockholm County (response rate of 70%).


METHODS
Frequency of beta2-adrenoceptor genotypes and alleles in relation to plasma lipid and lipoprotein levels and body mass index.


RESULTS
Individuals carrying the E27 allele and/or the G16 allele had significantly higher body mass index (BMI). Furthermore, carriers of the E27 allele had significantly higher plasma concentrations of cholesterol, triglycerides, VLDL cholesterol and VLDL triglycerides than did subjects homozygous for the Q allele.


CONCLUSIONS
The E27 allele of the beta2-adrenoceptor gene is associated with slightly to moderately elevated BMI and dyslipoproteinaemia involving triglyceride-rich lipoproteins in healthy younger and middle-aged men.
Ehrenborg
E
E
Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden. ewae@instmed.ks.se
Skogsberg
J
J
Ruotolo
G
G
Large
V
V
Eriksson
P
P
Arner
P
P
Hamsten
A
A
D000328:Adult; D000483:Alleles; D001120:Arginine / Q000235:genetics; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D015243:Cholesterol, VLDL / Q000097:blood; D005838:Genotype; D018698:Glutamic Acid / Q000235:genetics; D005973:Glutamine / Q000235:genetics; D005998:Glycine / Q000235:genetics; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D013548:Sweden; D014280:Triglycerides / Q000097:blood*
D015243:Cholesterol, VLDL; D018343:Receptors, Adrenergic, beta-2; D014280:Triglycerides; D005973:Glutamine; D018698:Glutamic Acid; D001120:Arginine; D002784:Cholesterol; D005998:Glycine