title: Retrospective study of prion-protein accumulation in tonsil and appendix tissues.
abstract: To identify individuals who could be at high risk of developing vCJD, a sensitive immunohistochemical technique was used to detect prion protein in a retrospective series of over 3000 tonsil and appendix specimens. No positives were detected but further studies are required to help reduce uncertainties about possible future numbers of vCJD cases in the UK.
authors.forename: J W
authors.initials: JW
authors.lastname: Ironside
authors.forename: D A
authors.initials: DA
authors.lastname: Hilton
authors.forename: A
authors.initials: A
authors.lastname: Ghani
authors.forename: N J
authors.initials: NJ
authors.lastname: Johnston
authors.forename: L
authors.initials: L
authors.lastname: Conyers
authors.forename: L M
authors.initials: LM
authors.lastname: McCardle
authors.forename: D
authors.initials: D
authors.lastname: Best
mesh_terms: D001065:Appendix / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000473:pathology*; D003430:Cross-Sectional Studies; D006801:Humans; D015994:Incidence; D014066:Palatine Tonsil / Q000473:pathology*; D011328:Prions / Q000032:analysis*; D012189:Retrospective Studies; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D011328:Prions