A new allele, HLA-B*1555, identified in an African patient awaiting bone marrow transplantation.
Human HLA genes exhibit extreme polymorphism, the extent of which is emphasised by the identification of an ever increasing number of new alleles by DNA-based typing strategies. Here we describe a novel allele, belonging to the HLA-B*15 group, which was identified in an African patient awaiting a bone marrow transplant This individual was shown to exhibit two HLA-B alleles, B*5301 and a new allele which has been named B*1555. B*1555 differs from B*1531 in exon 3 by a single nucleotide substitution. This substitution results in a change in the amino acid residue at position 97, which is located within the beta-pleated sheet region of the HLA molecule.
Hoddinott
M A
MA
Anthony Nolan Research Institute and Histocompatiblity Laboratories, The Royal Free Hospital, Hampstead, London, United Kingdom.
Cox
S T
ST
McWhinnie
A J
AJ
Marsh
S G
SG
Ogilvie
H
H
Madrigal
J A
JA
Little
A M
AM
D000349:Africa / Q000208:ethnology; D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001483:Base Sequence; D044383:Black People / Q000235:genetics*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005091:Exons; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D006113:United Kingdom
D015235:HLA-B Antigens