title: Seizure frequency and bilateral temporal abnormalities: a proton magnetic resonance spectroscopy of temporal lobe epilepsy.
abstract: Proton magnetic resonance spectroscopy ((1)H-MRS) was performed in seven healthy volunteers and 17 patients with temporal lobe epilepsy (TLE) to clarify the correlation of the severity of epilepsy with bilateral temporal changes in N-acetylaspartate (NAA), choline-containing compounds (Cho) and creatine + phosphocreatine (Cr). Despite unilateral EEG focus, bilateral temporal reduction in NAA /(Cho + Cr) was revealed in patients with intractable seizures. The potential for seizure generation correlated with the NAA /(Cho + Cr) reduction not only on the ipsilateral side but also on the contralateral side. Proton MRS proved to be a useful measurement for obtaining important information about the neuronal changes as well as the lateralization of the epileptogenic focus in TLE patients.
authors.affiliation: Section of Psychiatry and Behavioral Science, Tokyo Medical and Dental University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Someya
authors.forename: T
authors.initials: T
authors.lastname: Obata
authors.forename: T
authors.initials: T
authors.lastname: Suhara
authors.forename: Y
authors.initials: Y
authors.lastname: Ota
authors.forename: H
authors.initials: H
authors.lastname: Ikehira
authors.forename: S
authors.initials: S
authors.lastname: Tanada
authors.forename: K
authors.initials: K
authors.lastname: Hirakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Okubo
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004292:Dominance, Cerebral; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013702:Temporal Lobe / Q000378:metabolism* / Q000473:pathology
chemical_list: D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline