Histidin as a mercurial poisoning inhibitor.
Histidin has been shown to effectively inhibit coagulation of horse oxyhemoglobin (HbO(2)) modified by mercury(II) ion bound to reactive thiol groups of protein. Kinetic parameters were measured and the histidin-to-mercury binding constant was kinetically estimated. Histidin, as other pharmaceutically acceptable compounds with some mercury-binding capacity, has been suggested to alleviate mercury intoxication conditions.
Myshkin
A E
AE
Institute of Biochemical Physics of the Russian Academy of Sciences, Kosygin St. 4, Moscow V-334, 117977, Russia. myshkin@photonics.ru
Khromova
V S
VS
D000818:Animals; D006639:Histidine / Q000737:chemistry* / Q000494:pharmacology; D006736:Horses; D007700:Kinetics; D008630:Mercury Poisoning / Q000517:prevention & control*; D008706:Methemoglobin / Q000737:chemistry
D006639:Histidine; D008706:Methemoglobin