title: Drawing lines in the Drosophila wing: initiation of wing vein development.
abstract: It has been proposed that wing veins in Drosophila form at boundaries between discrete sectors of cells that subdivide the anterior-posterior axis of the developing wing primordium. Recently, analysis of events underlying initiation of vein formation suggests that there is a general developmental mechanism for drawing lines between adjacent domains of cells, which is referred to as 'for-export-only-signaling'. In this model, cells in one domain produce a short range signal to which they cannot respond. As a consequence of this constraint, cells lying in a narrow line immediately outside the signal-producing domain are the only cells that can respond to the signal by activating expression of vein-promoting genes.
authors.affiliation: Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093-0349, USA. bier@biomail.ucsd.edu
authors.forename: E
authors.initials: E
authors.lastname: Bier
mesh_terms: D000818:Animals; D005075:Biological Evolution; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development*; D014921:Wings, Animal / Q000254:growth & development*