title: Neuronal nitric oxide synthase immunoreactive neurons in the mammalian retina.
abstract: The development of immunocytochemistry has led to a better understanding of synaptic transmission carried out by neuroactive substances in the mammalian brain, including the retina. In the mammalian retina, nitric oxide (NO) is widely accepted as a neuromodulator. Histochemistry based on NADPH-d and immunocytochemistry based on nitric oxide synthase (NOS) have been used to identify the presence of nitric oxide in the mammalian retina. Certain types of amacrine cells and a class of displaced amacrine cells have been labeled consistently in all mammalian retinae studied to date. Other cell types showing NADPH-d reactivity or NOS immunoreactivity varied between species. NADPH-d reactive or NOS immunoreactive amacrine cells may serve as a source of NO for amacrine, bipolar, and ganglion cells in the inner retina, whereas interplexiform cells, bipolar cells, and horizontal cells may serve as a source of NO for the outer retina of mammals.
authors.affiliation: Department of Anatomy, College of Medicine, Catholic University of Korea, Seoul, Korea.
authors.forename: I B
authors.initials: IB
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Oh
authors.forename: M H
authors.initials: MH
authors.lastname: Chun
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008322:Mammals; D016253:Microscopy, Immunoelectron; D009252:NADPH Dehydrogenase / Q000032:analysis; D009474:Neurons / Q000201:enzymology* / Q000648:ultrastructure; D018377:Neurotransmitter Agents / Q000378:metabolism; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000032:analysis*; D052248:Nitric Oxide Synthase Type I; D012160:Retina / Q000166:cytology / Q000201:enzymology* / Q000648:ultrastructure; D017949:Retinal Cone Photoreceptor Cells / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000378:metabolism; D017948:Retinal Rod Photoreceptor Cells / Q000378:metabolism; D013045:Species Specificity
chemical_list: D018377:Neurotransmitter Agents; D009569:Nitric Oxide; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D009252:NADPH Dehydrogenase