Manganese superoxide dismutase gene polymorphism and schizophrenia: relation to tardive dyskinesia.
There has been increasing evidence that deranged superoxide dismutase (SOD) activities might be a risk factor for schizophrenia and/or tardive dyskinesia (TD). In the present study, we investigated the genetic association between a functional polymorphism (Ala-9Val) in the human manganese (Mn) SOD gene and schizophrenia or TD (192 schizophrenics: 39 with TD and 153 without TD; 141 controls). No significant differences in the allelic or genotypic distribution between schizophrenics and controls were observed. However, we did find a significant difference in genotypic distribution between schizophrenics with and those without TD (p =. 03). Moreover, decreased -9Ala (mutant) allele was found among patients with TD (p =.02; odds ratio = 0.29; 95% confidence interval = 0.10-0.83). In conjunction with previous findings of increased free radicals and decreased SOD activities in TD subjects, these results suggest that the -9Ala (high activity) MnSOD allele may play a role in protecting against susceptibility to TD in schizophrenics.
Hori
H
H
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ohmori
O
O
Shinkai
T
T
Kojima
H
H
Okano
C
C
Suzuki
T
T
Nakamura
J
J
D017677:Age Distribution; D000483:Alleles; D016022:Case-Control Studies; D015897:Comorbidity; D004409:Dyskinesia, Drug-Induced / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012559:Schizophrenia / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D013482:Superoxide Dismutase / Q000235:genetics*
D013482:Superoxide Dismutase