Action of ethanol on different skull and brain parameters in the chick embryo.
Fifty microliters of ethanol diluted in 50 microl of distilled water were injected into the air chamber of chick eggs immediately before their incubation, and modifications in a series of parameters were recorded. The somatic weight of the ethanol-treated embryos was lower compared with control and vehicle-administered embryos during days 13, 15, 17, and 19 of incubation, but was the same on day 21. The brain weight was lower in the ethanol-treated embryos on all the days studied (days 13, 15, 17, 19, and 21 of incubation). Skull measurements showed that the transverse anteroposterior and sagittal diameters were significantly smaller in ethanol-treated embryos compared with control and vehicle-administered embryos on days 17, 19, and 21 of incubation.
Roda-Moreno
J A
JA
Departamento de Ciencias Morfológicas, Instituto de Neurociencias Federico Olóriz, Facultad de Medicina, Universidad de Granada, Spain.
Pascual-Morenilla
M T
MT
Roda-Murillo
O
O
Lopez-Soler
M
M
Arrebola-Nacle
F
F
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002642:Chick Embryo; D000431:Ethanol / Q000494:pharmacology*; D009929:Organ Size; D012886:Skull / Q000187:drug effects / Q000196:embryology*; D013997:Time Factors
D002492:Central Nervous System Depressants; D000431:Ethanol