[Changes in pituitary gonadotropins according to body mass index and adipose tissue distribution, in postmenopausal women receiving different types of hormone replacement therapy].
OBJECTIVE
To establish how gonadotrophins levels are modified according to body mass index (BMI) and waist-hip ratio (WHR), in postmenopausal women receiving different types of hormone replacement therapy (HRT).


METHODS
Forty postmenopausal women were studied, and divided into two groups of 20 women each one (according to the HRT schedule administered (continuous or continuous combined). At baseline, three and six months, luteinizing hormone (Lh), follicle stimulating hormone (FSH) and estradiol (E2) serum levels were determined. The two groups were divided into two subgroups first according to BMI, and thereinafter according to WHR. Differences among the groups were assessed by Mann-Whitney U test. The changes along each treatment group, were determined by Wilcoxon test.


RESULTS
FSH and LH levels decreased and those of E2 increased at 3 and 6 months after the beginning of treatment in each one of the HRT schedules, but without differences among them. Upon subdividing the groups, the changes were similar to the undivided group.


CONCLUSIONS
It can be concluded that HRT modifies pituitary gonadotrophin secretion, but later changes exist in LH in obese and those with upper level body fat distribution.
Carranza Lira
S
S
Servicio de Ginecología Endocrina, Hospital de Gineco Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México, D.F.
Cortés Fuentes
E
E
D000273:Adipose Tissue; D015992:Body Mass Index; D015914:Estrogen Replacement Therapy; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*
D006065:Gonadotropins, Pituitary