Role of acetaldehyde in the induction of heart left ventricular atrial natriuretic peptide gene expression in rats.
We studied the effects of ethanol and acetaldehyde on myocardial gene expression of atrial natriuretic peptide (ANP) and growth of rats. Combined ethanol and calcium carbimide treatment increased blood-acetaldehyde levels and ANP mRNA levels by 40-60% in 2-8 day experiments, compared to the controls. The results suggest a role for acetaldehyde in the development of alcoholic heart dysfunction.
Jänkälä
H
H
Department of Clinical Chemistry, Helsinki University Central Hospital, Finland.
Eriksson CJP
Petersen
N E
NE
Härkönen
M
M
Mäki
T
T
D000079:Acetaldehyde / Q000009:adverse effects* / Q000097:blood; D000428:Alcohol Drinking / Q000009:adverse effects; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D001522:Behavior, Animal / Q000502:physiology; D015152:Blotting, Northern; D001835:Body Weight; D017931:DNA Primers / Q000235:genetics; D018076:DNA, Complementary / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D015870:Gene Expression / Q000187:drug effects* / Q000235:genetics*; D006352:Heart Ventricles / Q000187:drug effects*; D008297:Male; D012333:RNA, Messenger / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced*
D017931:DNA Primers; D018076:DNA, Complementary; D012333:RNA, Messenger; D000431:Ethanol; D009320:Atrial Natriuretic Factor; D000079:Acetaldehyde