title: Iris involvement in primary intraocular lymphoma: report of two cases and review of the literature.
abstract: Non-Hodgkin's lymphoma involves ocular tissues either as a primary tumor or as secondary metastasis from systemic disease. Diagnosis is based on the identification of malignant cells in the eye by biopsy. Although primary intraocular lymphoma cells have been identified in the optic nerve, ciliary body, and iris of a small number of patients by histopathology, these sites of infiltration have rarely been observed on clinical examination. We studied clinical and histopathological findings of two patients with iris infiltration by primary intraocular lymphoma and reviewed the findings of 163 cases reported in the literature.
authors.affiliation: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892-1857, USA.
authors.forename: G
authors.initials: G
authors.lastname: Velez
authors.forename: M D
authors.initials: MD
authors.lastname: de Smet
authors.forename: S M
authors.initials: SM
authors.lastname: Whitcup
authors.forename: M
authors.initials: M
authors.lastname: Robinson
authors.forename: R B
authors.initials: RB
authors.lastname: Nussenblatt
authors.forename: C C
authors.initials: CC
authors.lastname: Chan
mesh_terms: D001706:Biopsy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D015811:Iris Neoplasms / Q000473:pathology* / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity; D014822:Vitreous Body / Q000473:pathology