L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study.
The effects of L-alpha-glyceryl-phosphorylcholine (LGPC), a putative acetylcholine precursor, were studied on the pattern electroretinogram (PERG) in two rhesus monkeys. In the time interval 10-30 min after LGPC administration (85 mg/kg i.m.), the amplitude of the PERG increased significantly. In both monkeys the amplitude enhancement was more pronounced for low spatial frequency stimuli (1 cycle/degree) than for medium spatial frequency gratings (5 cycles/degree). This result suggests that besides the general facilitatory properties, LGPC may have specific spatial frequency tuning effects at the level of retinal information processing.
Antal
A
A
Department of Physiology, Szent-Györgyi Albert Medical University, Szeged, Hungary.
Kéri
S
S
Bodis-Wollner
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I
D000704:Analysis of Variance; D000818:Animals; D004596:Electroretinography / Q000187:drug effects*; D005997:Glycerylphosphorylcholine / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D010865:Pilot Projects; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000187:drug effects*
D005997:Glycerylphosphorylcholine