Aromatase inhibitors from Isodon excisus var. coreanus.
The diethyl ether extract of Isodon excisus var. coreanus exhibited significant inhibitory activity in aromatase assay. Bioactivity-guided fractionation of the extract led to the isolation of three active compounds: inflexin (ent-1alpha-hydroxy-3beta,6a-diacetoxykaur-16-en-11,15-dione ) (1), ursolic acid (2), and ursolic acid 3-O-acetate (3).
Jeong
H J
HJ
PCRPS and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, USA. Hyehjean@nmdhst.cc.nih.gov
Chang
L C
LC
Kim
H K
HK
Kim
I H
IH
Kinghorn
A D
AD
Pezzuto
J M
JM
D016588:Anticarcinogenic Agents / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*; D010920:Placenta / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D010936:Plant Extracts