Specific detection of epstein-barr virus in inflammatory pseudotumor of the spleen in a patient with a high serum level of soluble IL-2 receptor.
A case of inflammatory pseudotumor of the spleen is described in a 63-year-old woman who presented with an intrasplenic tumor and an elevated serum level of soluble interleukin 2 receptor (sIL-2R). Microscopic examination after removal of the spleen revealed that the tumor was composed of mixed cellular infiltrates, mainly lymphocytes and plasma cells, and spindle-cell proliferation. Epstein-Barr virus (EBV) was specifically detected in the tumor by in situ hybridization for EBV RNA. The serum level of sIL-2R level was normalized after splenectomy. EBV infection may play a role in the development of splenic inflammatory pseudotumor and the elevation of sIL-2R level.
Yamaguchi
M
M
Department of Surgery, Showa University Fujigaoka Hospital,Yokohama, Japan.
Yamamoto
T
T
Tate
G
G
Matsumoto
T
T
Matsumiya
A
A
Kuzume
M
M
Sanada
Y
Y
Kumada
K
K
D005260:Female; D006104:Granuloma, Plasma Cell / Q000097:blood / Q000175:diagnosis / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D013158:Splenic Diseases / Q000097:blood / Q000175:diagnosis / Q000821:virology*; D014057:Tomography, X-Ray Computed
D015375:Receptors, Interleukin-2