[Structural basis of the intracortical synchronization of epileptic potentials in the sensomotor region of the rat neocortex].
In control rats, penicillin-induced epileptiform discharges were completely synchronous in the neocortex sites at a distance of up to 4 mm from each other. Number of the cells decreased by 45.5% during 90 days in isolated cortical slabs and the synchronisation disappeared. The data obtained show that the loss of large pyramidal neurones of the layer V entailed a loss of the spatial synchronisation. The main axonal collaterals of large pyramidal neurones of the layer V could be followed horizontally for a distance of up to 2 mm in the somatosensory cortex. The neuronal network formed by the large pyramidal neurones of the layer V seems to provide a spatial synchronisation in the neocortex.
Pasikova
N V
NV
Institute of Higher Nervous Activity and Neurophysiology, Russian Acad. Sci., Moscow, Russia.
Marchenko
V G
VG
Kositsin
N S
NS
D000818:Animals; D003344:Cortical Synchronization; D004594:Electrophysiology; D004827:Epilepsy / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology*; D019579:Neocortex / Q000473:pathology / Q000503:physiopathology*; D010406:Penicillins; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology*
D010406:Penicillins