title: Contamination of human milk in Middle Hesse, Germany--a cross-sectional study on the changing levels of chlorinated pesticides, PCB congeners and recent levels of nitro musks.
abstract: Human milk samples from women in Middle Hesse, Germany were chemically analyzed for contamination levels of alpha-, beta- and gamma-HCH, HCB, p,p'-DDE and p,p'-DDT as well as the PCB-congeners no. 28, 31, 49, 52, 101, 118, 138, 153, 156, 170 and 180. Changes in concentrations of these compounds in human milk over an extended time period were studied by comparing samples from 1984/85, 1990/91 and 1995. In addition, concentrations of the nitro-aromatic compounds musk xylene and musk ketone were determined in the 1995 samples. The study showed statistically highly significant (p<0.001) reductions in levels of beta- and gamma-HCH, HCB, p,p'-DDE and p,p'-DDT, in human milk from 1995 compared to samples from 1984/85. A weakly significant reduction (p<0.05) of alpha-HCH was also observed. For low-chlorinated PCB congeners, on the other hand, a highly significant increase of PCB no. 28 was detected and concentrations of congeners no. 31, 49 and 52 remained unchanged. Concentrations of the high-chlorinated congeners no. 101, 138, 153 and 180 dropped (highly significant). A highly significant reduction of PCB no. 118 and 156 occurred between 1990/91 and 1995, but a highly significant increase was found for no. 170. Lower levels of hydrocarbon contamination of human milk samples from 1995 than were found in samples from 1984/85 and 1990/91 can be seen to result partially from voluntary reductions, but primarily reflect restrictive environmental legislation in the Federal Republic of Germany. Mean concentrations of musk xylene and musk ketone in samples from 1995 were 41 microg/kg and 10 microg/kg milk fat, respectively.
authors.affiliation: Staatliches Medizinal-, Lebensmittel- und Veterinäruntersuchungsamt Mittelhessen, Giessen.
authors.forename: M
authors.initials: M
authors.lastname: Ott
authors.forename: K
authors.initials: K
authors.lastname: Failing
authors.forename: U
authors.initials: U
authors.lastname: Lang
authors.forename: C
authors.initials: C
authors.lastname: Schubring
authors.forename: H J
authors.initials: HJ
authors.lastname: Gent
authors.forename: S
authors.initials: S
authors.lastname: Georgii
authors.forename: H
authors.initials: H
authors.lastname: Brunn
mesh_terms: D000328:Adult; D002849:Chromatography, Gas; D003430:Cross-Sectional Studies; D005229:Fatty Acids, Monounsaturated / Q000032:analysis*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005858:Germany; D006801:Humans; D007306:Insecticides / Q000032:analysis*; D008895:Milk, Human / Q000737:chemistry*; D009574:Nitro Compounds / Q000032:analysis*; D009812:Odorants / Q000032:analysis*; D010573:Pesticide Residues / Q000032:analysis*; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D013997:Time Factors
chemical_list: D005229:Fatty Acids, Monounsaturated; D007306:Insecticides; D009574:Nitro Compounds; D010573:Pesticide Residues; C008563:musk; D011078:Polychlorinated Biphenyls