Susceptibility of clinical isolates of Bacteroides fragilis group strains to cefoxitin, cefoperazone and ticarcillin/clavulanate.
A total of 40 strains of the B. fragilis group was isolated from clinical specimens in two hospital centers in Fortaleza from 1993 to 1997. The most frequently isolated species was Bacteroides fragilis (19 strains) and most isolates came from intra-abdominal and wound infections. The susceptibility profile was traced for cefoxitin, cefoperazone and ticarcillin-clavulanate by using the agar dilution reference method. All isolates were susceptible to ticarcillin-clavulanate (128/2 microg/ml). Resistance rates of 15 and 70% were detected to cefoxitin (64 microg/ml) and cefoperazone (64 microg/ml), respectively. Such regional results permit a better orientation in choosing this group of antibiotics for prophylaxis and therapy especially in relation to cefoxitin, which is frequently used in the hospital centers studied.
Peixoto Júnior
A A
AA
Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, CE, Brasil.
Rocha
M M
MM
Moreira
J L
JL
Carvalho
C B
CB
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects*; D002438:Cefoperazone / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology; D019818:Clavulanic Acid / Q000494:pharmacology; D013982:Ticarcillin / Q000494:pharmacology; D018440:beta-Lactam Resistance
D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D002440:Cefoxitin; D002438:Cefoperazone; D013982:Ticarcillin