title: Transoral CO2 laser for surgical management of glottic carcinoma in situ.
abstract: OBJECTIVE
  In carcinoma in situ (CIS) tumors malignant cells have not penetrated the basement membrane and therefore have no metastatic potential. Treatment strategies of CIS are topics of ongoing discussion. The aim of this study was to evaluate long-term results of CO2 laser therapy in laryngeal CIS.
  
  
  METHODS
  From 1986 to 1995, 29 patients with glottic CIS with a minimum follow-up of 2 years were treated initially with transoral CO2 laser surgery and were included is this series.
  
  
  RESULTS
  A complete removal of the tumor was possible with superficial laser cordectomy in 21 patients and with subligamental laser cordectomy in 8 cases. There was no tumor-related death in this series. Repeated laser resections were performed in four patients for local recurrences. No patient required total laryngectomy or radiotherapy during a follow-up ranging from 25 to 143 months.
  
  
  CONCLUSIONS
  Local control rates presented in this study are superior to those previously reported with conventional surgery and similar to those after radiotherapy. The ultimate rate of larynx preservation was seven times higher than reported after radiotherapy. Our results add further support to the observation that laser surgery is the best treatment option for CIS of the larynx. Based on the material of this study, recommended treatment for CIS is CO2 laser resection in combination with a meticulous follow-up for early recognition of local recurrence.
authors.affiliation: Department of Oto-Rhino-Laryngology, University of Cologne, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Damm
authors.forename: C
authors.initials: C
authors.lastname: Sittel
authors.forename: M
authors.initials: M
authors.lastname: Streppel
authors.forename: H E
authors.initials: HE
authors.lastname: Eckel
mesh_terms: D000368:Aged; D002245:Carbon Dioxide; D002278:Carcinoma in Situ / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009960:Oropharynx; D011182:Postoperative Care; D011183:Postoperative Complications; D011300:Preoperative Care; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014832:Voice Disorders / Q000175:diagnosis; D014833:Voice Quality
chemical_list: D002245:Carbon Dioxide