[The synthetic peptide D-(iEW) (thymodepressin) protects bone marrow CFU-S from ionizing radiation exposure].
Synthetic polypeptide D-(iEW) (Thymodepressin) was shown to reduce the bone marrow CFU-S in the S-phase of cell cycle. Apparently, due to this property the agent being administered 2 days before the irradiation with 4 Gy causes a prominent restoration of the CFU-S population afterwards. The 3-5 times higher value of this parameter as compared to the control (irradiation only) is likely to be connected to the increased "survival" of the Thymodepressin-protected CFU-S after the treatment with ionizing irradiation.
Semina
O V
OV
Medical Radiological Research Centre, Russian Academy of Medical Sciences, Obninsk, Russia. mrrc@obninsk.ru
Deĭgin
V I
VI
Semenets
T N
TN
Beziaev
G P
GP
Poverennyĭ
A M
AM
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D003114:Colony-Forming Units Assay; D005260:Female; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D013997:Time Factors
D010455:Peptides; D011837:Radiation-Protective Agents