title: Cutaneous malakoplakia: a report of two cases with the use of anti-BCG for the detection for micro-organisms.
abstract: Malakoplakia is an uncommon granulomatous infectious disease that is found primarily in the genito-urinary tract, but may rarely involve the skin. Histologic findings are marked by the presence of foamy macrophages containing basophilic concentric spherules, the Michaelis-Gutman bodies. Micro-organisms are not readily identifiable. Immunostaining with polyclonal anti-mycobacterium bovis (BCG) has been described as a method of identifying bacterial and fungal organisms in situations where organisms may be sparse. We report 2 cases of cutaneous malakoplakia with demonstration of organisms by immunostaining with anti-BCG antibodies.
authors.affiliation: Pinkus Dermatopathology Laboratory, Monroe, MI 48161, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Mehregan
authors.forename: A H
authors.initials: AH
authors.lastname: Mehregan
authors.forename: D A
authors.initials: DA
authors.lastname: Mehregan
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D001365:Axilla; D006119:Groin; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008287:Malacoplakia / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009163:Mycobacterium bovis / Q000276:immunology; D012867:Skin / Q000473:pathology; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis* / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial