A practical large-scale synthesis of 17alpha-acetoxy-11beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione (CDB-2914).
A new practical synthesis of 17alpha-acetoxy-11beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione (CDB-2914) is described. The synthesis gives easily isolable solids at all steps and is amenable to large-scale process.
Rao
P N
PN
Department of Organic Chemistry, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78245-0549, USA. pnrao@sfbr.org
Acosta
C K
CK
Bahr
M L
ML
Burdett
J E
JE
Cessac
J W
JW
Morrison
P A
PA
Kim
H K
HK
D002855:Chromatography, Thin Layer / Q000379:methods; D003283:Contraceptives, Postcoital, Synthetic / Q000138:chemical synthesis* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009649:Norpregnadienes / Q000138:chemical synthesis* / Q000302:isolation & purification; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
D003283:Contraceptives, Postcoital, Synthetic; D009649:Norpregnadienes; C094854:ulipristal