title: Primary lumbosacral Wilms tumour associated with occult spinal dysraphism.
abstract: A 4-year-old child presenting with sudden-onset paraplegia and a sacral tumour in association with spina bifida occulta is reported. There were no stigmata of spinal dysraphism at birth. Imaging studies confirmed a sacral tumour with extradural extension up to T10 and spinal dysraphism. The histological features of the extradural and sacral components of the tumour were consistent with a Wilms tumour. The differential diagnosis included a primary sacral teratoma containing Wilms tumour elements or a primary extrarenal Wilms tumour arising in association with a spinal dysraphism. There was no clinical response to chemotherapy or radiotherapy.
authors.affiliation: Department of Pathology, University of Natal Medical School, Durban, South Africa. govendh@med.und.ac.za
authors.forename: D
authors.initials: D
authors.lastname: Govender
authors.forename: G P
authors.initials: GP
authors.lastname: Hadley
authors.forename: S S
authors.initials: SS
authors.lastname: Nadvi
authors.forename: R B
authors.initials: RB
authors.lastname: Donnellan
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D012447:Sacrum / Q000473:pathology* / Q000601:surgery; D016135:Spinal Dysraphism / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013125:Spinal Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013724:Teratoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D009396:Wilms Tumor / Q000150:complications / Q000473:pathology* / Q000601:surgery