Synthesis and cytotoxic activity of acetogenin analogues.
A set of 16 new simplified analogues of acetogenins has been designed based on: (i) the replacement of the bis THF moiety of these natural products by an ethylene glycol bis ether unit; (ii) the introduction of different lipophilic side chains (alkyl, aryl, dialkylamino, O-cholesteryl); (iii) the presence of the same terminal isolactone. In vitro cytotoxic activity against L1210 leukemia is reported.
Rodier
S
S
Laboratoire de Synthèse et Réactivité des Substances Naturelles, Université de Poitiers et CNRS, France.
Le Huérou
Y
Y
Renoux
B
B
Doyon
J
J
Renard
P
P
Pierré
A
A
Gesson
J P
JP
Grée
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology*; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000473:pathology
D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones; C112079:isomurisolenin