title: Magnetization transfer and diffusion-weighted imaging in nocturnal frontal lobe epilepsy.
abstract: The authors assessed the presence of brain abnormalities in 21 patients with nocturnal frontal lobe epilepsy (NFLE), using magnetization transfer ratio (MTR) and mean diffusivity (;D) histograms. Compared with healthy volunteers and patients with idiopathic generalized epilepsy, patients with NFLE had lower MTR (p = 0.002 and 0.01) and;D (p = 0.03 and 0.04) histogram peak heights. Subtle and widespread abnormalities related to intra- and extracellular distribution and motion of water are detectable in the brains of patients with NFLE.
authors.affiliation: Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Ferini-Strambi
authors.forename: M
authors.initials: M
authors.lastname: Bozzali
authors.forename: M
authors.initials: M
authors.lastname: Cercignani
authors.forename: A
authors.initials: A
authors.lastname: Oldani
authors.forename: M
authors.initials: M
authors.lastname: Zucconi
authors.forename: M
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002940:Circadian Rhythm; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D004829:Epilepsy, Generalized / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D015588:Observer Variation