title: Systemic anti-inflammatory effect of somatostatin released from capsaicin-sensitive vagal and sciatic sensory fibres of the rat and guinea-pig.
abstract: The systemic anti-inflammatory effect induced by antidromic sensory nerve stimulation was investigated in rats and guinea-pigs. In atropine-pretreated rats, bilateral antidromic stimulation of vagal afferent fibres (8 Hz, 20 min, at C-fibre strength) inhibited plasma extravasation induced by 1% mustard oil on the acutely denervated hindlegs by 36.45+/-3.95%. Both the prevention of this inhibitory effect by cysteamine pretreatment and the stimulation-evoked rise of plasma somatostatin-like immunoreactivity in the two species suggest a mediator role of neural somatostatin. Since this response was blocked by systemic capsaicin pretreatment and slightly reduced after subdiaphragmal vagotomy, participation of thoracic capsaicin-sensitive afferents is indicated. In guinea-pigs pretreated with guanethidine and pipecuronium, antidromic sciatic nerve stimulation induced 45.46+/-5.08% inhibition on the contralateral leg and increased plasma somatostatin-like immunoreactivity. It is concluded that somatostatin released from the activated vagal capsaicin-sensitive sensory nerve terminals of the rat and somatic nerves of the guinea-pigs exerts a systemic humoral function.
authors.affiliation: Department of Pharmacology and Pharmacotherapy, University Medical School of Pécs, H-7601 P.O.Box 99, Pécs, Hungary.
authors.forename: M
authors.initials: M
authors.lastname: Thán
authors.forename: J
authors.initials: J
authors.lastname: Németh
authors.forename: Z
authors.initials: Z
authors.lastname: Szilvássy
authors.forename: E
authors.initials: E
authors.lastname: Pintér
authors.forename: Z
authors.initials: Z
authors.lastname: Helyes
authors.forename: J
authors.initials: J
authors.lastname: Szolcsányi
mesh_terms: D000344:Afferent Pathways; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood* / Q000276:immunology; D001794:Blood Pressure / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D004558:Electric Stimulation; D005119:Extravasation of Diagnostic and Therapeutic Materials; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D006614:Hindlimb; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology; D009149:Mustard Plant; D009412:Nerve Fibers / Q000187:drug effects*; D017300:Pipecuronium / Q000494:pharmacology; D010936:Plant Extracts / Q000009:adverse effects; D010938:Plant Oils; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects* / Q000378:metabolism; D012867:Skin / Q000098:blood supply / Q000294:innervation / Q000473:pathology; D013004:Somatostatin / Q000097:blood* / Q000276:immunology; D014630:Vagus Nerve / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D010938:Plant Oils; D017300:Pipecuronium; D013004:Somatostatin; D002211:Capsaicin; C027793:mustard oil; D006145:Guanethidine