Serum p53 autoantibodies in the follow-up of head and neck cancer patients.
p53 autoantibodies (AAB) are a fairly new serological parameter in patients with malignancies. Although the actual mechanism of how they develop is still unclear, it seems that these AAB could be of prognostic relevance. Very few studies demonstrated the usefulness of p53 AAB in the follow-up of cancer patients. In this study, 109 patients with head and neck cancer were investigated using an ELISA for the presence of p53 AAB in their serum and were followed-up for at least 36 months. In 21 of the cancer patients, p53 serum AAB were detected. In 5/21 p53-seropositive AAB patients, a correlation with the clinical course was observed. Sixteen of the p53-positive patients did not show any significant AAB titer changes during the follow-up, and no significant correlation with the clinical course was seen. According to these results, the clinical value of p53 AAB in the follow-up of patients with head and neck cancer seems to be limited.
Gottschlich
S
S
Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Germany. gottschlich@hno.uni-kiel.de
Maune
S
S
Maass
J D
JD
Görögh
T
T
Hoffmann
M
M
Hoffmann-Fazel
A
A
Meyer
J
J
Werner
J A
JA
Rudert
H
H
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
D001323:Autoantibodies; D016159:Tumor Suppressor Protein p53