Lipid acetylation reactions and the metabolism of platelet-activating factor.
In this review properties of lipid acetyltransferase enzymes are outlined. The three activities of interest are lyso PAF acetyltransferase (acetyl CoA: 1-alkyl-sn-glycero-3-phosphocholine acetyltransferase), AGP acetyltransferase (acetyl CoA: 1-alkyl sn-glycero-3-phosphate acetyltransferase) and a transacetylase activity that can transfer acetyl groups from PAF to lipid acceptors in the formation of 1-alkenyl-2-acetyl-sn-glycero-3-phosphoethanolamine and N-acetyl sphingosine (C2 ceramide). This review focuses on the role of acetyltransferases and transacetylases within the metabolism of platelet-activating factor and specifically addresses characteristics of the enzymes, including subcellular localization, substrate selectivity, and enzymatic regulation.
Baker
R R
RR
Department of Biochemistry, University of Toronto, Canada.
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D002518:Ceramides / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D010972:Platelet Activating Factor / Q000378:metabolism*
D002518:Ceramides; D010972:Platelet Activating Factor; D000123:Acetyltransferases; C052591:alkylglycerophosphate 2-O-acetyltransferase; C046035:1-alkylglycerophosphocholine acetyltransferase