Serum glutathione S-transferase alpha as a measure of hepatocellular function following prolonged anaesthesia with sevoflurane and halothane in paediatric patients.
We studied the effects of prolonged anaesthesia (4.3-7.7 h) with sevoflurane and halothane on hepatic function in 14 paediatric patients. Hepatic function was assessed using serum concentrations of liver-specific glutathione S-transferase alpha (GSTA) before and 0, 3 and 15 h after the end of anaesthesia. A transient significant increase in GSTA over baseline was observed in the sevoflurane group, but not in the halothane group, and the difference between the groups was not significant. These data suggest that, although statistically insignificant, the use of sevoflurane for prolonged anaesthesia in paediatric patients is more likely than halothane to be involved in damage to hepatic function.
Iwanaga
Y
Y
Department of Anesthesiology and Emergency Medicine, Kagawa Medical University,1750-1 Ikenobe Miki-cho Kagawa, Japan.
Komatsu
H
H
Yokono
S
S
Ogli
K
K
D000704:Analysis of Variance; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005982:Glutathione Transferase / Q000097:blood* / Q000187:drug effects; D006221:Halothane / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000097:blood* / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage* / Q000009:adverse effects; D000077149:Sevoflurane; D013997:Time Factors
D018685:Anesthetics, Inhalation; D007527:Isoenzymes; D008738:Methyl Ethers; D000077149:Sevoflurane; D005982:Glutathione Transferase; C119995:glutathione S-transferase alpha; D006221:Halothane