Antiplasmodial compounds from the wood-decayed fungus Xylaria sp. BCC 1067.
Bioassay-guided fractionation of the extract from the wood-decayed fungus Xylaria sp. BCC 1067 led to the isolation of five antiplasmodial compounds, (-)-depudecin, (+)-phaseolinone, (+)-phomenone, 19,20-epoxycytochalasin Q, and (E)-methyl 3-(4-methoxyphenoxy)propenoate. These structures were elucidated using spectroscopic methods, especially NMR analysis.
Isaka
M
M
Jaturapat
A
A
Kladwang
W
W
Punya
J
J
Lertwerawat
Y
Y
Tanticharoen
M
M
Thebtaranonth
Y
Y
D000466:Alkadienes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000466:Alkadienes; D000962:Antimalarials; D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D005233:Fatty Alcohols; D009284:Naphthols; D012717:Sesquiterpenes; C072251:depudecin; C016657:phomenone; C056401:phaseolinone