title: L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. A pilot study.
abstract: The effects of L-alpha-glyceryl-phosphorylcholine (LGPC), a putative acetylcholine precursor, were studied on the pattern electroretinogram (PERG) in two rhesus monkeys. In the time interval 10-30 min after LGPC administration (85 mg/kg i.m.), the amplitude of the PERG increased significantly. In both monkeys the amplitude enhancement was more pronounced for low spatial frequency stimuli (1 cycle/degree) than for medium spatial frequency gratings (5 cycles/degree). This result suggests that besides the general facilitatory properties, LGPC may have specific spatial frequency tuning effects at the level of retinal information processing.
authors.affiliation: Department of Physiology, Szent-Györgyi Albert Medical University, Szeged, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Antal
authors.forename: S
authors.initials: S
authors.lastname: Kéri
authors.forename: I
authors.initials: I
authors.lastname: Bodis-Wollner
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004596:Electroretinography / Q000187:drug effects*; D005997:Glycerylphosphorylcholine / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D010865:Pilot Projects; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000187:drug effects*
chemical_list: D005997:Glycerylphosphorylcholine