[Cellular neurothekeoma, a rare cutaneous tumor. Anatomo-clinical and immunohistochemical study of 2 cases].
Cellular neurothekeoma is an unusual cutaneous tumor described in 1986. We report two new cases in 14-year-old girls. Both tumors measured less than one centimeter and were located on the forearm and the shoulder. They had a plexiform architecture and were developed in the dermis and the dermo-hypodermic junction. Spindle and epithelioid tumor cells were immunoreactive for vimentin, NKI-C3, NSE, CD68 and smooth muscle actin. There was no recurrence 2 and 7 months after the operation. Cellular neurothekeoma is a benign tumor. Its histogenesis is still unknown. Histological and immunohistochemical features, with positivity of the tumor cells for NKI-C3, a non specific melanocytic marker, and negativity for S-100 protein and HMB-45, allow to differentiate cellular neurothekeoma from myxoid neurothekeoma and melanocytic tumors.
Chatelain
D
D
Service d'Anatomie Pathologique, Hôpital Nord, Amiens.
Ricard
J
J
Colombat
M
M
Ghighi
C
C
Thelu
F
F
Cordonnier
C
C
Gontier
M F
MF
Sevestre
H
H
D000199:Actins / Q000032:analysis; D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D018321:Neurothekeoma / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
D000199:Actins; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D010751:Phosphopyruvate Hydratase; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule