Synthesis of feruloyl-myo-inositols and their inhibitory effects on superoxide generation.
Ester compounds consisting of ferulic acid and myo-inositol, obtained from rice bran, were synthesized. The inhibitory effects of these feruloyl-myo-inositols on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced superoxide (O2-) generation were examined using differentiated HL-60 cells. Among the derivatives tested, only 3,4,5,6-tetra-O-acetyl-1,2-di-O-[3-(4'-acetoxy-3'-methoxyphenyl)-2-pr openoyl]-myo-inositol (3) showed a distinct inhibitory activity.
Hosoda
A
A
Industrial Technology Center of Wakayama Prefecture, Ogura, Japan.
Nomura
E
E
Murakami
A
A
Koshimizu
K
K
Ohigashi
H
H
Mizuno
K
K
Taniguchi
H
H
D016588:Anticarcinogenic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D004952:Esters / Q000737:chemistry; D006098:Granulocytes / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D015394:Molecular Structure; D013481:Superoxides / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
C415224:3,4,5,6-tetra-O-acetyl-1,2-di-O-(3-(4'-acetoxy-3'-methoxyphenyl)-2-propenoyl)myo-inositol; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D004952:Esters; D013481:Superoxides; D007294:Inositol; D013755:Tetradecanoylphorbol Acetate