title: Synthesis and cytotoxic activity of acetogenin analogues.
abstract: A set of 16 new simplified analogues of acetogenins has been designed based on: (i) the replacement of the bis THF moiety of these natural products by an ethylene glycol bis ether unit; (ii) the introduction of different lipophilic side chains (alkyl, aryl, dialkylamino, O-cholesteryl); (iii) the presence of the same terminal isolactone. In vitro cytotoxic activity against L1210 leukemia is reported.
authors.affiliation: Laboratoire de Synthèse et Réactivité des Substances Naturelles, Université de Poitiers et CNRS, France.
authors.forename: S
authors.initials: S
authors.lastname: Rodier
authors.forename: Y
authors.initials: Y
authors.lastname: Le Huérou
authors.forename: B
authors.initials: B
authors.lastname: Renoux
authors.forename: J
authors.initials: J
authors.lastname: Doyon
authors.forename: P
authors.initials: P
authors.lastname: Renard
authors.forename: A
authors.initials: A
authors.lastname: Pierré
authors.forename: J P
authors.initials: JP
authors.lastname: Gesson
authors.forename: R
authors.initials: R
authors.lastname: Grée
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology*; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D007783:Lactones; C112079:isomurisolenin