Anti- and pro-oxidative properties of PADMA 28, a Tibetan herbal formulation.
There is growing public interest in traditional medicine. PADMA 28, a multicompound herbal preparation derived from Tibetan medicine, has proven efficacy in some clinical trials and tests at the cellular level. We report here on studies of PADMA 28 at the molecular level. Extracts of PADMA 28 contain both reducing and metal ion-chelating substances. In this way, PADMA 28 acts as a powerful antioxidant or prooxidant, depending on its concentration and the reaction under study.
Suter
M
M
Institute of Biochemistry, Swiss Federal Institute of Technology, Zürich, Switzerland.
Richter
C
C
D000975:Antioxidants / Q000737:chemistry* / Q000378:metabolism; D003574:Cytochrome c Group / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects; D005290:Ferric Compounds / Q000378:metabolism; D005296:Ferrous Compounds / Q000378:metabolism; D006735:Horseradish Peroxidase / Q000378:metabolism; D007502:Iron Chelating Agents / Q000737:chemistry; D008518:Medicine, East Asian Traditional; D009584:Nitrogen / Q000037:antagonists & inhibitors / Q000378:metabolism; D016877:Oxidants / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry* / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D019163:Reducing Agents / Q000737:chemistry; D013379:Substrate Specificity
D000975:Antioxidants; D003574:Cytochrome c Group; D005290:Ferric Compounds; D005296:Ferrous Compounds; D007502:Iron Chelating Agents; D016877:Oxidants; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D019163:Reducing Agents; C066069:Padma 28; D006735:Horseradish Peroxidase; D009584:Nitrogen