Effect of alcohol on growth of Plasmodium falciparum.
The effect of ethanol on the in vitro growth of the malaria parasite Plasmodium falciparum was investigated. 17 mM (0.08%) and 85 mM (0.39%) ethanol were added to parasite cultures and growth was determined for six days. A significant growth inhibition for both ethanol concentrations was observed on each day. It reached 65% for 85 mM ethanol after six days of incubation. Malarial parasites are strongly inhibited by ethanol concentrations which are attainable by extensive alcohol consumption.
Lell
B
B
Sektion Humanparasitologie, Institut für Tropenmedizin, Tübingen, Federal Republic of Germany.
Binh
V Q
VQ
Kremsner
P G
PG
D000349:Africa / Q000453:epidemiology; D000428:Alcohol Drinking; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D008288:Malaria / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000469:parasitology
D000890:Anti-Infective Agents; D000431:Ethanol