[Benznidazole in the primary chemoprophylaxis of the reactivation of Chagas' disease in chronic chagasic patients using corticosteroids at immunosuppressive doses: is there sufficient evidence for recommending its use?].
There is evidence that trypanosomicide drugs prevent the parasitological reactivation of Chagas' disease in patients under corticosteroid therapy. On the other hand there are few reports of clinical reactivation of this disease associated with the use of these immunosuppressive drugs. Primary chemoprophylaxis with trypanosomicide in this situation should not be recommended before being assessed by a randomized controlled trial.
Nishioka
S de A
Sde A
Centro de Ciências Biomédicas, Universidade Federal de Uberlândia, Uberlândia, MG, 38411-160, Brasil. snishioka@hc.ufu.br
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D014355:Chagas Disease / Q000188:drug therapy / Q000517:prevention & control*; D002908:Chronic Disease; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011322:Primary Prevention / Q000379:methods*; D014344:Trypanocidal Agents / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole