title: Effects of age on elastic moduli of human lungs.
abstract: The model of the lung as an elastic continuum undergoing small distortions from a uniformly inflated state has been used to describe many lung deformation problems. Lung stress-strain material properties needed for this model are described by two elastic moduli: the bulk modulus, which describes a uniform inflation, and the shear modulus, which describes an isovolume deformation. In this study we measured the bulk modulus and shear modulus of human lungs obtained at autopsy at several fixed transpulmonary pressures (Ptp). The bulk modulus was obtained from small pressure-volume perturbations on different points of the deflation pressure-volume curve. The shear modulus was obtained from indentation tests on the lung surface. The results indicated that, at a constant Ptp, both bulk and shear moduli increased with age, and the increase was greater at higher Ptp values. The micromechanical basis for these changes remains to be elucidated.
authors.affiliation: Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA. laifook@pop.uky.edu
authors.forename: S J
authors.initials: SJ
authors.lastname: Lai-Fook
authors.forename: R E
authors.initials: RE
authors.lastname: Hyatt
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D002102:Cadaver; D002648:Child; D004548:Elasticity; D005260:Female; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance / Q000502:physiology; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D016012:Poisson Distribution; D011312:Pressure; D015656:Respiratory Mechanics / Q000502:physiology; D013499:Surface Properties