title: Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark.
abstract: The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria. mailbox@ibadan.skannet.com
authors.forename: O A
authors.initials: OA
authors.lastname: Olajide
authors.forename: S O
authors.initials: SO
authors.lastname: Awe
authors.forename: J M
authors.initials: JM
authors.lastname: Makinde
authors.forename: A I
authors.initials: AI
authors.lastname: Ekhelar
authors.forename: A
authors.initials: A
authors.lastname: Olusola
authors.forename: O
authors.initials: O
authors.lastname: Morebise
authors.forename: D T
authors.initials: DT
authors.lastname: Okpako
mesh_terms: D019342:Acetic Acid; D000349:Africa; D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy; D002199:Capillary Permeability / Q000187:drug effects; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control; D005557:Formaldehyde; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D019441:Plant Epidermis / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D015003:Yeasts
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D005557:Formaldehyde; D019342:Acetic Acid