The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.
The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell biology and immunology studies to explain the role of the actin cytoskeleton in creating the molecular basis for immunological synapse formation and T cell signaling.
Dustin
M L
ML
Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis MO 63110, USA. dustin@immunology.wustl.edu
Cooper
J A
JA
D000199:Actins / Q000276:immunology; D000818:Animals; D002450:Cell Communication / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology* / Q000648:ultrastructure; D006801:Humans; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*
D000199:Actins