title: Modeling the dual pacemaker system of the tau mutant hamster.
abstract: Circadian pacemakers in many animals are compound. In rodents, a two-oscillator model of the pacemaker composed of an evening (E) and a morning (M) oscillator has been proposed based on the phenomenon of "splitting" and bimodal activity peaks. The authors describe computer simulations of the pacemaker in tau mutant hamsters viewed as a system of mutually coupled E and M oscillators. These mutant animals exhibit normal type 1 PRCs when released into DD but make a transition to a type 0 PRC when held for many weeks in DD. The two-oscillator model describes particularly well some recent behavioral experiments on these hamsters. The authors sought to determine the relationships between oscillator amplitude, period, PRC, and activity duration through computer simulations. Two complementary approaches proved useful for analyzing weakly coupled oscillator systems. The authors adopted a "distinct oscillators" view when considering the component E and M oscillators and a "system" view when considering the system as a whole. For strongly coupled systems, only the system view is appropriate. The simulations lead the authors to two primary conjectures: (1) the total amplitude of the pacemaker system in tau mutant hamsters is less than in the wild-type animals, and (2) the coupling between the unit E and M oscillators is weakened during continuous exposure of hamsters to DD. As coupling strength decreases, activity duration (alpha) increases due to a greater phase difference between E and M. At the same time, the total amplitude of the system decreases, causing an increase in observable PRC amplitudes. Reduced coupling also increases the relative autonomy of the unit oscillators. The relatively autonomous phase shifts of E and M oscillators can account for both immediate compression and expansion of activity bands in tau mutant and wild-type hamsters subjected to light pulses.
authors.affiliation: Department of Biology, NSF Center for Biological Timing, University of Virginia, Charlottesville 22903-2477, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Menaker
authors.forename: W O
authors.initials: WO
authors.lastname: Friesen
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D003198:Computer Simulation; D006224:Cricetinae / Q000235:genetics* / Q000502:physiology*; D008954:Models, Biological; D009154:Mutation / Q000502:physiology*; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins