CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.
The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+ subset of DC and that this pathway is important in establishing interferon gamma-dependent resistance to the protozoan parasite Toxoplasma gondii. These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function.
Aliberti
J
J
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. jaliberti@niaid.nih.gov
Reis e Sousa
C
C
Schito
M
M
Hieny
S
S
Wells
T
T
Huffnagle
G B
GB
Sher
A
A
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D007111:Immunity, Cellular; D018664:Interleukin-12 / Q000276:immunology*; D051379:Mice; D019713:Receptors, CCR5 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology*
D000953:Antigens, Protozoan; D016827:CD8 Antigens; D019713:Receptors, CCR5; D018664:Interleukin-12