Recurrent blastomycosis of the central nervous system: case report and review.
Although blastomycosis of the central nervous system (CNS) occurs in approximately 4% of patients with blastomycosis, recurrent CNS blastomycosis is very rare. We review the clinical features, treatment, and outcome of 4 previously reported cases. We also report a case of recurrent CNS blastomycosis successfully treated with surgery and liposomal amphotericin B after an inadequate response to amphotericin B therapy. This treatment may be an alternate approach for management of similar cases.
Chowfin
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A
University of North Dakota School of Medicine, Fargo, ND 58122, USA. achowfin@hotmail.com
Tight
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R
Mitchell
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S
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001759:Blastomycosis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D001921:Brain / Q000000981:diagnostic imaging; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D008081:Liposomes; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012008:Recurrence; D016896:Treatment Outcome
D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B