[Tests for cell membrane destabilization in assessing activity-progression of chronic glomerulonephritis].
OBJECTIVE
To study the role of cell membrane destabilization (MD) in the serum and urine in assessing activity/progression of primary chronic glomerulonephritis (CGN).


METHODS
The trial entered 163 patients (mean age 38 +/- 7.3 years) with primary CGN in active phase, 64 patients with CGN in remission and 24 controls. The groups were compared by MD (urine phospholipids--PL, blood and urine ethanolamine--EA), indexes of activity and sclerosis (AI and SI), lipid peroxidation (LPO), etc.


RESULTS
In active glomerulonephritis (GN) vs inactive one there were high levels of 24-h proteinuria, AI, PL and EA in the urine, malonic dialdehyde (MDA) and hydroperoxides (HP) in the blood. SI was similar in both groups. In active GN significant correlations were found between urinary SI, systolic and diastolic pressure, elevated levels of beta-lipoproteins and triglycerides; between blood EA and 24-h proteinuria, blood platelets, beta-lipoproteins, triglycerides, MDA, urine EA.


CONCLUSIONS
LPO and MD play an essential role in GN pathogenesis. They reflect activity of inflammation in GN irrespective of the activity type and clinicomorphological form of GN, absence or presence of CRF.
Sigitova
O N
ON
Maksudova
A N
AN
Miasoutova
L I
LI
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002462:Cell Membrane / Q000378:metabolism; D002908:Chronic Disease; D018450:Disease Progression; D019856:Ethanolamine / Q000378:metabolism*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood* / Q000473:pathology / Q000652:urine*; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011379:Prognosis; D011507:Proteinuria / Q000652:urine; D013256:Steroids / Q000378:metabolism*
D015415:Biomarkers; D010743:Phospholipids; D013256:Steroids; D008315:Malondialdehyde; D019856:Ethanolamine; D006861:Hydrogen Peroxide