title: Asymmetric wolff rearrangement reactions with alpha-alkylated-alpha-diazoketones: stereoselective synthesis of alpha-substituted-beta-amino acid derivatives
abstract: Photoinduced asymmetric Wolff rearrangement reactions were performed with alpha-amino-alpha'-methyl-alpha'-diazoketones to afford alpha-methyl-beta-amino acid esters with good stereoselectivity. Factors that may influence the stereochemistry were examined, including steric effects and temperature dependence, which had a great impact on the stereochemistry.
authors.affiliation: Department of Chemistry, AstraZeneca R&D Montreal, 7171 Frederick-Banting, St. Laurent, Quebec, Canada H4S 1Z9.
authors.initials: H
authors.lastname: Yang
authors.initials: K
authors.lastname: Foster
authors.initials: CR
authors.lastname: Stephenson
authors.initials: W
authors.lastname: Brown
authors.initials: E
authors.lastname: Roberts