The serotonergic agent m-chlorophenylpiperazine induces migraine attacks: A controlled study.
In a double-blind study versus placebo, the serotonergic agent m-chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24 hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT2B,2C,1A receptor subtypes in the pathophysiology of migraine.
Leone
M
M
Istituto Nazionale Neurologico Carlo Besta, Milan, Italy.
Attanasio
A
A
Croci
D
D
Filippini
G
G
D'Amico
D
D
Grazzi
L
L
Nespolo
A
A
Bussone
G
G
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000139:chemically induced* / Q000503:physiopathology; D010147:Pain Measurement; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood
D010879:Piperazines; D017366:Serotonin Receptor Agonists; C015068:1-(3-chlorophenyl)piperazine