title: Large plantar wart caused by human papillomavirus-66 and resolution by topical cidofovir therapy.
abstract: Warts can be difficult to diagnose and to treat in the setting of human immunodeficiency virus (HIV) infection. A 37-year-old woman with a background of HIV presented with a large verrucous plaque involving her right foot. Human papillomavirus (HPV)-66 was identified in the lesional skin biopsy sample and in scrapings obtained from her cervix. The wart rapidly responded to topical cidofovir therapy. HPV-66 is a novel HPV type to be associated with verruca vulgaris. Topical cidofovir should be further investigated as an alternative treatment modality for verruca vulgaris.
authors.affiliation: Department of Dermatology, the Section of Gynecology Surgery, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Davis
authors.forename: B S
authors.initials: BS
authors.lastname: Gostout
authors.forename: R M
authors.initials: RM
authors.lastname: McGovern
authors.forename: D H
authors.initials: DH
authors.lastname: Persing
authors.forename: R L
authors.initials: RL
authors.lastname: Schut
authors.forename: M R
authors.initials: MR
authors.lastname: Pittelkow
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D000287:Administration, Topical; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D001706:Biopsy; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004279:DNA, Viral / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D027383:Papillomaviridae / Q000187:drug effects / Q000235:genetics; D030361:Papillomavirus Infections / Q000188:drug therapy / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology / Q000821:virology; D014860:Warts / Q000188:drug therapy / Q000473:pathology / Q000821:virology*
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir