title: Plasminogen activator inhibitor-1: defining characteristics in the cerebrospinal fluid of newborns.
abstract: We measured plasminogen activator inhibitor-1 levels in the cerebrospinal fluid and plasma of newborns with and without posthemorrhagic hydrocephalus. We found that plasminogen activator inhibitor-1 levels in the cerebrospinal fluid of healthy newborns are <10 mg/mL but are greatly elevated in patients who have posthemorrhagic hydrocephalus and correlate directly with cerebrospinal fluid D-dimer and protein levels.
authors.affiliation: Division of Newborn Medicine and the Department of Laboratory Medicine, Children's Hospital, Boston, MA 02115, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Hansen
authors.forename: C
authors.initials: C
authors.lastname: Lapp
authors.forename: C
authors.initials: C
authors.lastname: Brugnara
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005342:Fibrinolysis; D005865:Gestational Age; D006801:Humans; D006849:Hydrocephalus / Q000097:blood / Q000134:cerebrospinal fluid*; D007231:Infant, Newborn / Q000502:physiology*; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000134:cerebrospinal fluid*; D012016:Reference Values
chemical_list: D017395:Plasminogen Activator Inhibitor 1