Chemokine receptor-related genetic sequences in an african green monkey simian cytomegalovirus-derived stealth virus.
The US28 gene of human cytomegalovirus (HCMV) codes a cell surface receptor for both beta chemokine and fractalkine molecules. This receptor facilitates HCMV-induced cell fusion and virus dissemination and influences susceptibility to infection with other viruses, including the human immunodeficiency virus. Five adjacent but divergent open reading frames that potentially code for molecules related to the US28 protein of HCMV are present in an African green monkey simian cytomegalovirus-derived stealth virus. This finding implies a role for chemokines in the pathogenicity of at least some stealth-adapted viruses. It may also help explain the apparent therapeutic benefit achieved in certain stealth virus-infected patients treated with agents that downregulate chemokine production.
Martin
W J
WJ
Center for Complex Infectious Diseases, Rosemead, California, 91770, USA.
D000595:Amino Acid Sequence; D000818:Animals; D018932:Chemokine CCL2 / Q000235:genetics*; D002522:Chlorocebus aethiops / Q000821:virology*; D003001:Cloning, Molecular; D003587:Cytomegalovirus / Q000235:genetics* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D015673:Fatigue Syndrome, Chronic / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000235:genetics*
C515334:CCR2 protein, human; C515336:Ccr2 protein, rat; D018932:Chemokine CCL2; D004279:DNA, Viral; D054390:Receptors, CCR2; D019707:Receptors, Chemokine