title: [Paraplegia episodes revealing tuberculous myelitis].
abstract: A 38 year-old woman, without previous medical history, presented, since 1993, several paraplegic fits carrying herself progressively through to a severe paraplegia. Diagnoses successively proposed were spinal cord compressions by slipped discs, spinal cord infarct and multiple sclerosis. In November 1998, the patient presented back pain and fever. Spinal cord magnetic resonance imaging (MRI) revealed a mildly enlarged dorsal cord with signal abnormalities. The lesions were isointense on T1-weighted images, hyperintense on T2-weighted images and showed a ringlike contrast enhancement. A lumbar puncture showed a trouble cerebrospinal fluid (CSF) with leucocytes 600/mm(3) (85 p.100 polynuclear), protein 6.7 g/l, glucose 0.26 g/l, chloride 109 mmol/l. The patient was first treated with parenteral unspecific antibiotherapy. Microbiological studies of blood and CSF were negative. CSF examination with polymerase chain reaction (PCR) was positive for Mycobacterium tuberculosis. Clinical (pain and fever) symptoms and CSF abnormalities decreased after antituberculous treatment. However, paraparesis remain severe. Spinal tuberculous localizations often lead to diagnostic and therapeutic errors. Improvement of spinal cord MRI sequences and using of PCR technics in CSF would contribute to reduce these difficulties.
authors.affiliation: Clinique Neurologique, Hôpital Roger Salengro, CHRU de Lille.
authors.forename: X
authors.initials: X
authors.lastname: Douay
authors.forename: J
authors.initials: J
authors.lastname: de Seze
authors.forename: T
authors.initials: T
authors.lastname: Stojkovic
authors.forename: J Y
authors.initials: JY
authors.lastname: Gauvrit
authors.forename: C
authors.initials: C
authors.lastname: Savage
authors.forename: J P
authors.initials: JP
authors.lastname: Pruvo
authors.forename: P
authors.initials: P
authors.lastname: Vermersch
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005578:Fosfomycin / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D010264:Paraplegia / Q000209:etiology*; D014399:Tuberculosis, Spinal / Q000134:cerebrospinal fluid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology
chemical_list: D000995:Antitubercular Agents; D005578:Fosfomycin; D002939:Ciprofloxacin