p75 neurotrophin receptor signaling: mechanisms for neurotrophic modulation of cell stress?
The recent recognition that the p75 neurotrophin receptor, p75((NTR)), can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75(NTR) signaling remain to be fully characterized, many of the currently identified pathways activated by p75(NTR) may be generally characterized as stress response signals. This review describes recent advances in identifying the molecular components involved in p75(NTR) signal transduction and suggests that p75(NTR) signaling may more aptly serve as a general mechanism for the transduction and modulation of stress signals.
Dobrowsky
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Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas, USA. dobrowsky@ukans.edu
Carter
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BD
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D004268:DNA-Binding Proteins; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B / Q000502:physiology; D020800:Receptor, Nerve Growth Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013107:Sphingolipids / Q000502:physiology
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; D020800:Receptor, Nerve Growth Factor; D013107:Sphingolipids; C402289:Zfp110 protein, mouse