Syntheses and antifilarial profile of 7-chloro-4-(substituted amino) quinolines: a new class of antifilarial agents.
The syntheses of 7-chloro-4-(substituted amino) quinolines (2-22) and their antifilarial activities are delineated. Some of the screened compounds have shown promising filarial response and sterilization effect on female Acanthocheilonema viteae in rodents.
Tewari
S
S
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Chauhan
P M
PM
Bhaduri
A P
AP
Fatima
N
N
Chatterjee
R K
RK
D000634:Aminoquinolines / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004153:Dipetalonema / Q000187:drug effects*; D004154:Dipetalonema Infections / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D005260:Female; D005369:Filaricides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015394:Molecular Structure; D009115:Muridae
D000634:Aminoquinolines; D005369:Filaricides