title: Role of acetaldehyde in the induction of heart left ventricular atrial natriuretic peptide gene expression in rats.
abstract: We studied the effects of ethanol and acetaldehyde on myocardial gene expression of atrial natriuretic peptide (ANP) and growth of rats. Combined ethanol and calcium carbimide treatment increased blood-acetaldehyde levels and ANP mRNA levels by 40-60% in 2-8 day experiments, compared to the controls. The results suggest a role for acetaldehyde in the development of alcoholic heart dysfunction.
authors.affiliation: Department of Clinical Chemistry, Helsinki University Central Hospital, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Jänkälä
authors.lastname: Eriksson CJP
authors.forename: N E
authors.initials: NE
authors.lastname: Petersen
authors.forename: M
authors.initials: M
authors.lastname: Härkönen
authors.forename: T
authors.initials: T
authors.lastname: Mäki
mesh_terms: D000079:Acetaldehyde / Q000009:adverse effects* / Q000097:blood; D000428:Alcohol Drinking / Q000009:adverse effects; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D001522:Behavior, Animal / Q000502:physiology; D015152:Blotting, Northern; D001835:Body Weight; D017931:DNA Primers / Q000235:genetics; D018076:DNA, Complementary / Q000187:drug effects; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D015870:Gene Expression / Q000187:drug effects* / Q000235:genetics*; D006352:Heart Ventricles / Q000187:drug effects*; D008297:Male; D012333:RNA, Messenger / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced*
chemical_list: D017931:DNA Primers; D018076:DNA, Complementary; D012333:RNA, Messenger; D000431:Ethanol; D009320:Atrial Natriuretic Factor; D000079:Acetaldehyde