A new synthetic approach to 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives via a [2 + 2 + 2] cycloaddition reaction.
Tetrahydroisoquinoline-3-carboxylic acid derivatives are prepared via a [2 + 2 + 2] cycloaddition reaction as a key step using Wilkinson's and CpCo(CO)2 catalysts.
Kotha
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Department of Chemistry, Indian Institute of Technology-Bombay, Mumbai, India. srk@ether.chem.iitb.ernet.in
Sreenivasachary
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D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D015195:Drug Design; D007546:Isoquinolines / Q000138:chemical synthesis*
D000480:Alkynes; D007546:Isoquinolines