title: Co-morbidity in Gaucher's disease results of a nationwide enquiry in Spain.
abstract: OBJECTIVE
  Gaucher's disease (GD) is an autosomal recessive disease produced by mutations of the Glucocerebrosidase gene. Carriers are considered to be healthy subjects because there is no manifestation of the disease, but they show signs of macrophage disfunction. The aim of the study was to determine if GD patients and non affected carriers risk suffering other diseases when compared to healthy non-carrier relatives.
  
  
  METHODS
  
  
  
  METHODS
  Epidemiologic study of historic cohorts. The fact that they have one or two mutated alleles has been considered to be the risk factor leading to other conditions (Dementia, Parkinson disease, Ischemic stroke, Ischemic heart disease, Non rheumatic valvular disease, Cancer hematological and non-hematological, Pulmonary fibrosis, Tuberculosis, Gallstones and Schizophrenia). All people, patients, carriers and healthy controls shared the same genetical background and environmental influence. - Patients and relatives enrolled on the Spanish Gaucher Disease Registry were evaluated.
  
  
  METHODS
  For the Relative-Risk calculation the Mantel-Haenszel test was applied. Yates' correction was used when size sample was too small. A value of p <0.05 was accepted for statistical significance.
  
  
  RESULTS
  370 people, from 79 different families, were surveyed. We received evaluable information from 45 families (56%), totalling 258 people (69%): 59 healthy subjects (Mean age 32. 20, RANGE: 10-85; M 57.63%/F 42.37%), 132 carriers (Mean age 35.91, RANGE: 1-79; M 56.82%/F 43.18%) and 67 patients (Mean age 32.16, Range: 1-76; M 44.78%/F 55.22%. - Relative Risk of suffering any disease with regard to Gaucher's status: Patient vs Healthy 9.69 (95% Confidence interval [CI] 2.00-63.99; p 0.0006). Patient vs Carrier 3.74 (CI 1.53-9.27; p 0.001); Carrier vs Healthy 2.59 (CI 0. 52-12.50; p 0.21). Relative Risk of suffering any disease with regard to sex was 3.96 for female patients (CI 1.01-16.75; p 0.02) and 1.34 for female carriers (CI 0.27-6.75; p = 0.68).
  
  
  CONCLUSIONS
  As a group, Gaucher's patients seem to have a greater risk of suffering other common unrelated diseases than carriers or healthy relatives. This excess of risk is particularly higher among female patients and can not be explained in terms of differences in age. Carrier status doesn't seem to highten the risk of suffering other diseases.
authors.affiliation: Servicio de Medicina Interna B, Hospital Clínico Universitario, Avda S. Juan Bosco no 15, 50009 Zaragoza, Spain. mibh-jperez@hcu-lblesa.es.
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Calvo
authors.forename: M
authors.initials: M
authors.lastname: Bernal
authors.forename: P
authors.initials: P
authors.lastname: Giraldo
authors.forename: M A
authors.initials: MA
authors.lastname: Torralba
authors.forename: F
authors.initials: F
authors.lastname: Civeira
authors.forename: M
authors.initials: M
authors.lastname: Giralt
authors.forename: M
authors.initials: M
authors.lastname: Pocovi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002648:Child; D015331:Cohort Studies; D005260:Female; D005776:Gaucher Disease / Q000150:complications / Q000453:epidemiology / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005962:Glucosylceramidase / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
chemical_list: D005962:Glucosylceramidase