title: Syntheses and antifilarial profile of 7-chloro-4-(substituted amino) quinolines: a new class of antifilarial agents.
abstract: The syntheses of 7-chloro-4-(substituted amino) quinolines (2-22) and their antifilarial activities are delineated. Some of the screened compounds have shown promising filarial response and sterilization effect on female Acanthocheilonema viteae in rodents.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Tewari
authors.forename: P M
authors.initials: PM
authors.lastname: Chauhan
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: N
authors.initials: N
authors.lastname: Fatima
authors.forename: R K
authors.initials: RK
authors.lastname: Chatterjee
mesh_terms: D000634:Aminoquinolines / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004153:Dipetalonema / Q000187:drug effects*; D004154:Dipetalonema Infections / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D005260:Female; D005369:Filaricides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D015394:Molecular Structure; D009115:Muridae
chemical_list: D000634:Aminoquinolines; D005369:Filaricides