[Inhibition of renal carbonic anhydrase as a respiratory stimulant-- an obsolete indication?].
Inhibition of carbonic anhydrase in general or specific inhibition of one the different isoenzymes results in a significant metabolic acidosis due to renal bicarbonate loss. The increase of arterial pCO2 stimulates central and peripheral chemoreceptors and enhances ventilation. The inhibition of carbonic anhydrase as a respiratory stimulant is an accepted measure for the prevention of acute mountain sickness, has been used for a restricted number of subjects with sleep-disordered breathing or chronic hypoxaemic lung disease. The few indications and the narrow therapeutic index restrict the use of carbonic anhydrase blockers as stimulants for ventilation.
Schöni
M H
MH
Universitäts-Kinderklinik, Inselspital Bern. martin.h.schoeni@insel.ch
D000532:Altitude Sickness / Q000188:drug therapy; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy; D012143:Respiratory Physiological Phenomena / Q000187:drug effects*; D012891:Sleep Apnea Syndromes / Q000188:drug therapy
D002257:Carbonic Anhydrase Inhibitors