Resistance of helicobacter pylori to metronidazole, tetracycline and amoxycillin.
Resistance to metronidazole, tetracycline and amoxycillin, and beta-lactamase production were determined for 153 clinical isolates of Helicobacter pylori. Of these isolates, 77.8% were resistant to metronidazole (MIC > 8 mg/L), 58.8% to tetracycline (MIC > 16 mg/L) and 71.9% to amoxycillin (MIC > 0.5 mg/L); 39.2% were multiresistant. Resistance to metronidazole was more common in isolates from females than in those from males (P < 0.05). None of the isolates produced beta-lactamase, so the mechanism of amoxycillin resistance was not linked to production of beta-lactamase.
Wu
H
H
Department of Microbiology, Shanghai Second Medical University, Chongqing South Road 280, China 200025. wu4hong@263.net
Shi
X D
XD
Wang
H T
HT
Liu
J X
JX
D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D000658:Amoxicillin; D013752:Tetracycline