title: sp2-bridged diaryl retinoids: effects of bridge-region substitution on retinoid X receptor (RXR) selectivity.
abstract: RXR class selectivity and RXR transcriptional activation activity compared to those for the retinoic acid receptor subtypes were enhanced on the 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylethenyl)be nzoic acid scaffold and its 3-methyl analogue by replacing their 1,1-ethenyl bridge by a 1,1-(2-methylpropenyl) or cyclopropylidenylmethylene group.
authors.affiliation: Medicinal Chemistry Department, Molecular Medicine Research Institute, Mountain View, CA 94043, USA. mdawson@mmrx.org
authors.forename: M I
authors.initials: MI
authors.lastname: Dawson
authors.forename: P D
authors.initials: PD
authors.lastname: Hobbs
authors.forename: L
authors.initials: L
authors.lastname: Jong
authors.forename: D
authors.initials: D
authors.lastname: Xiao
authors.forename: W R
authors.initials: WR
authors.lastname: Chao
authors.forename: C
authors.initials: C
authors.lastname: Pan
authors.forename: X K
authors.initials: XK
authors.lastname: Zhang
mesh_terms: D002455:Cell Division / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D047488:Retinoid X Receptors; D012176:Retinoids / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D014157:Transcription Factors / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D012176:Retinoids; D014157:Transcription Factors