SRPrises in RNA-protein recognition.
The recent structure determination of the phylogenetically conserved cor re of the signal recognition particle (SRP) reveals a novel of highly un usual RNA-protein interface, where non-canonical base pairs play a centr al role. The structure shows how a helix-turn-helix motif can be employ ed to bind RNA and offers hints as to how the signal peptide is recogniz ed by the SRP.
Rupert
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PB
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
Ferré-D'amaré
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AR
D019077:Helix-Turn-Helix Motifs / Q000502:physiology; D008958:Models, Molecular; D011485:Protein Binding / Q000235:genetics* / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D012313:RNA / Q000378:metabolism*; D018271:Signal Recognition Particle / Q000378:metabolism*
D018271:Signal Recognition Particle; D012313:RNA