Polyaromatic Scavenger Reagents (PAHSR): A New Methodology for Rapid Purification in Solution-Phase Combinatorial Synthesis.
A new method of purification of solution-phase combinatorial libraries has been developed. Development of a chemically inert polyaromatic anchor with a reactive "scavenger reagent" (PAHSR) allows unreacted reagents and impurities to be removed from a reaction by absorption of the PAHSR to charcoal and simple filtration.
Warmus
JS
Department of Chemistry, Parke-Davis Pharmaceutical Research, A Division of Warner-Lambert, 2800 Plymouth Road, Ann Arbor, Michigan 48105.
da Silva MI