Bilateral diffuse uveal melanocytic proliferation and uterine cancer. A case report.
OBJECTIVE
To report a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), a rare paraneoplastic syndrome causing visual loss in patients with systemic carcinoma.


RESULTS
A 70-year-old woman developed visual symptoms 13 months after surgery and local irradiation therapy for uterine cancer. Following bilateral external beam irradiation supplemented with subsequent drainage of subretinal fluid in the left eye, the visual acuity improved from 0.01 to 0.15 in this eye only. The visual acuity remained at this level until she died 4 1/4 years after the onset of eye symptoms.


CONCLUSIONS
This is the fourth case that survived longer than 24 months after the onset of visual symptoms of the 22 previously reported cases with BDUMP. It demonstrates that radiotherapy may have a vision-preserving effect in this group of patients. The patient also developed two different paraneoplastic phenomena--a nephrotic syndrome before and BDUMP after treatment for uterine cancer.
Ritland
J S
JS
University Eye Department, The National Hospital, University of Oslo, Norway.
Eide
N
N
Tausjø
J
J
D000368:Aged; D002455:Cell Division; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008544:Melanocytes / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D012160:Retina / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D014603:Uveal Diseases / Q000150:complications* / Q000175:diagnosis / Q000628:therapy