Is cancer an autoimmune process dependent on anti-apoptotic autoantibodies?
Dysregulated apoptosis is a potentially important mechanism in the pathogenesis of cancer. Autoantibodies, which inhibit apoptosis, have recently been identified in patients with malignant diseases. We suggest that such inhibitory autoantibodies participate in tumorigenesis. These views may provide a basis for the increased incidence of cancer in patients with autoimmune diseases and have novel therapeutic implications for cancer.
Bar-Dayan
Y
Y
Department of Medicine B and Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer Hospital and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. baardayan@netvision.net.il
Kaveri
S V
SV
Kazatchkine
M D
MD
Shoenfeld
Y
Y
D017209:Apoptosis / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000150:complications*; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies