HLA-DRB genotypes in Japanese patients with renal cell carcinoma.
OBJECTIVE
Several clinical features, such as the spontaneous regression of some renal cell carcinoma (RCC) metastases after nephrectomy, suggest immune involvement in tumor destruction.


METHODS
We investigated the role of genetic variation at the HLA class II loci in RCC by analyzing the HLA-DR antigen and HLA-DRB1, DRB3, DRB4 and DRB5 alleles in 55 patients using the polymerase chain rection.


RESULTS
No statistically significant differences were observed in the frequency of the HLA-DR antigen or HLA-DRB3, DRB4, or DRB5 genes between the patients and a healthy control group. On the other hand, the HLA-DRB1*0403 and *1202 alleles were significantly more frequent in the patients than in the controls (p < 0.001 and p < 0.01, respectively).


CONCLUSIONS
RCC might be linked to these two alleles in Japanese patients.
Kojima
Y
Y
Department of Urology, Osaka University Medical School, Osaka, Japan.
Takahara
S
S
Nonomura
N
N
Sada
M
M
Tsuji
T
T
Hatori
M
M
Fujioka
H
H
Kuroda
H
H
Miki
T
T
Okuyama
A
A
D000328:Adult; D000368:Aged; D000483:Alleles; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D016130:Immunophenotyping; D007564:Japan; D007680:Kidney Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D006684:HLA-DR Antigens