Can magnesium act as a second messenger? Current data on translocation induced by various biologically active substances.
Free intracellular Mg2+([Mg2+]i) can potentially integrate the signals from hormones, cellular metabolism and organismal ion homeostasis and affect the activities of ion channel and other effectors. Interest in [Mg2+]i has been heightened by recent reports that small changes in [Mg2+]i in the physiological range can significantly modulate important cellular functions. In addition, a variety of new evidence shows that [Mg2+]i instantaneously changes following stimulation with various biologically active substances. These observations suggest that [Mg2+]i may act as a second messenger.
Takaya
J
J
Department of Pediatrics, Kansai Medical University, Osaka, Japan.
Higashino
H
H
Kobayashi
Y
Y
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D007473:Ion Channels; D007477:Ions; D008274:Magnesium / Q000378:metabolism* / Q000502:physiology*; D051381:Rats; D015290:Second Messenger Systems; D015398:Signal Transduction
D007473:Ion Channels; D007477:Ions; D008274:Magnesium; D002118:Calcium