title: Preoperative predictors of late postoperative outcome among patients with nonischemic mitral regurgitation with 'high risk' descriptors and comparison with unoperated patients.
abstract: Among patients with chronic nonischemic mitral regurgitation (MR), high short-term mortality risk can be identified by left (LV) and/or right ventricular (RV) ejection fraction (EF) criteria (LVEF </=45% and/or RVEF </=30%). Mitral valve replacement or repair (MVR) significantly improves outcome in this subgroup, but predictors of late postoperative survival are not known, and the benefit of MVR has not been defined in patients matched for severity of LV and RV dysfunction. Therefore, prospective assessment of 14 consecutive high risk MR patients was performed before MVR and during 9 years (average) postoperatively to define echocardiographic and radionuclide angiographic predictors of survival; survival also was evaluated in a contemporaneous series of 9 high risk unoperated MR patients, and in subgroups of operated and unoperated patients matched for EF. Of 14 MVR patients, 4 died (3 cardiac: 1 sudden, 2 congestive heart failure). Only preoperative RVEF </=20% significantly predicted postoperative deaths (rest p = 0.032; exercise p = 0.05). Of 9 unoperated patients, 8 died. Mortality risk of unoperated patients remained higher than that of MVR patients when groups were matched for preoperative LVEF (p = 0.0001). Among patients with RVEF >20%, MVR significantly improved survival versus medical treatment (rest: p < 0.0001, exercise: p = 0.0003). In high risk MR patients, MVR improves survival; preoperative RV performance can define subgroups with different long-term postoperative survival.
authors.affiliation: Division of Cardiovascular Pathophysiology and Department of Cardiothoracic Surgery, Joan and Sanford I. Weill Medical College of Cornell University, The New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY, USA.
authors.forename: D
authors.initials: D
authors.lastname: Wencker
authors.forename: J S
authors.initials: JS
authors.lastname: Borer
authors.forename: C
authors.initials: C
authors.lastname: Hochreiter
authors.forename: R B
authors.initials: RB
authors.lastname: Devereux
authors.forename: M J
authors.initials: MJ
authors.lastname: Roman
authors.forename: P
authors.initials: P
authors.lastname: Kligfield
authors.forename: P
authors.initials: P
authors.lastname: Supino
authors.forename: K
authors.initials: K
authors.lastname: Krieger
authors.forename: O W
authors.initials: OW
authors.lastname: Isom
mesh_terms: D002908:Chronic Disease; D017023:Coronary Angiography; D004452:Echocardiography; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology* / Q000601:surgery; D011184:Postoperative Period; D011446:Prospective Studies; D015635:Radionuclide Ventriculography; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology*; D015996:Survival Rate; D016896:Treatment Outcome; D016276:Ventricular Function / Q000502:physiology*