NMDA receptor activation: critical role in oxidant tissue injury.
The excitatory amino acid glutamate serves important neurologic functions, but overactivation of its N-methyl-D-aspartate (NMDA) receptor is toxic to neurons (excitotoxicity). We report that NMDA receptor blocker MK-801 (dizocilpine maleate) attenuated oxidant injury induced by paraquat or by xanthine oxidase. We conclude that excitotoxicity may be a key factor in oxidant tissue injury.
Said
S I
SI
VA Medical Center, Northport, NY, USA.
Pakbaz
H
H
Berisha
H I
HI
Raza
S
S
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D006168:Guinea Pigs; D009498:Neurotoxins / Q000633:toxicity*; D016877:Oxidants / Q000633:toxicity*; D018384:Oxidative Stress; D010269:Paraquat / Q000633:toxicity*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000502:physiology; D014969:Xanthine Oxidase / Q000633:toxicity*
D018691:Excitatory Amino Acid Antagonists; D009498:Neurotoxins; D016877:Oxidants; D017382:Reactive Oxygen Species; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D014969:Xanthine Oxidase; D010269:Paraquat