Structure and properties of members of the hGH family: a review.
This review will summarize the properties of five variant forms of human growth hormone: a disulfide dimer, a glycosylated form, 20 kD-hGH, and two peptides made up of portions of 22 kD-hGH. The two pituitary peptides (hGH(1-43) and hGH(44-191)) have, respectively, insulin-potentiating and anti-insulin properties. Both have been detected in serum. The shorter peptide may prove to be useful in decreasing the amount of exogenous insulin required by diabetics. The larger, strongly anti-insulin peptide, may be involved in diabetic retinopathy. We believe that this peptide is the long sought after diabetogenic substance of the pituitary gland.
Lewis
U J
UJ
Neuroscience Institute, University of California Santa Barbara, 93117, USA.
Sinha
Y N
YN
Lewis
G P
GP
D003920:Diabetes Mellitus / Q000209:etiology; D014644:Genetic Variation; D019382:Human Growth Hormone / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008970:Molecular Weight; D005810:Multigene Family / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology; D012160:Retina / Q000378:metabolism; D013329:Structure-Activity Relationship
D019382:Human Growth Hormone