Anticonvulsive activity of Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.
The ethanolic extracts of leaves of Albizzia lebbeck and flowers of Hibiscus rosa sinesis and the petroleum ether extract of flowers of Butea monosperma exhibited anticonvulsant activity. The bioassay guided fractionation indicated that the anticonvulsant activity lies in the methanolic fraction of chloroform soluble part of ethanolic extract of the leaves of A. lebbeck, acetone soluble part of ethanolic extract of H. rosa sinesis flowers and acetone soluble part of petroleum ether extract of B. monosperma flowers. The fractions protected animals from maximum electro shock, electrical kindling and pentylenetetrazole-induced convulsions in mice. The fractions also inhibited convulsions induced by lithium-pilocarpine and electrical kindling. However, they failed to protect animals from strychnine-induced convulsions. The fractions antagonised the behavioral effects of D-amphetamine and potentiated the pentobarbitone-induced sleep. The fractions raised brain contents of gamma-aminobutyric acid (GABA) and serotonin. These fractions were found to be anxiogenic and general depressant of central nervous system.
Kasture
V S
VS
N.D.M.V.P. Samaj's College of Pharmacy, 422002, Nasik, India.
Chopde
C T
CT
Deshmukh
V K
VK
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000037:antagonists & inhibitors / Q000633:toxicity; D003292:Convulsants; D004597:Electroshock; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008094:Lithium; D008297:Male; D051379:Mice; D018721:Muscarinic Agonists; D010424:Pentobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010433:Pentylenetetrazole; D010862:Pilocarpine; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000927:Anticonvulsants; D000697:Central Nervous System Stimulants; D003292:Convulsants; D006993:Hypnotics and Sedatives; D018721:Muscarinic Agonists; D010936:Plant Extracts; D010862:Pilocarpine; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D008094:Lithium; D000661:Amphetamine; D010424:Pentobarbital; D010433:Pentylenetetrazole