Inhibition of the protective IgA response by ketotifen is related to the inflammatory reaction in the peritoneal cavity and intestinal mucosa of BALB/c mice infected with Trichinella spiralis.
Interleukin-5 (IL-5) production, eosinophilia, and IgA responses of BALB/c mice infected with Trichinella spiralis were measured in the peritoneal cavity and intestinal mucosa. Ketotifen, an anti-allergic compound, was used to control the inflammatory response. IgA responses differed against adult and muscle stages of the parasite and between the intestine and the peritoneal cavity. IL-5 and eosinophil production also differed between the intestine and the peritoneal cavity. The occurrence of parasite-specific IgA antibodies in the peritoneal cavity may reflect the migration of cells from the lamina propria. Following ketotifen treatment there was a reduction in the IL-5, eosinophilic, and IgA responses; these responses affected both the size of worms and the number of worms.
Doligalska
M
M
Department of Parasitology, Institute of Zoology, University of Warsaw, Poland. mdolig@eco1.biol.uw.edu.pl
Laskowska
M
M
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology; D000909:Antibodies, Helminth / Q000096:biosynthesis*; D004804:Eosinophils / Q000166:cytology; D006790:Host-Parasite Interactions; D007070:Immunoglobulin A / Q000096:biosynthesis*; D015848:Interleukin-5 / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D007665:Ketotifen / Q000494:pharmacology*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010529:Peritoneal Cavity / Q000473:pathology; D017160:Trichinella spiralis / Q000276:immunology*; D014235:Trichinellosis / Q000276:immunology*
D018926:Anti-Allergic Agents; D000909:Antibodies, Helminth; D007070:Immunoglobulin A; D015848:Interleukin-5; D007665:Ketotifen