title: [Differential approach to administration of cosaar].
abstract: Effects of cosaar (MSD) on central hemodynamics and microcirculation were studied in 20 patients with arterial hypertension under acute pharmacological test and on the treatment week 2, 6 and 8. Two variants of hemodynamic response were registered: hypokinetic and hyperkinetic. Unidirectional hemodynamic changes occurred both in short- and long-term therapy. This allows to use the short course for differential choice of patients for cosaar therapy. The best effect of cosaar is expected in patients with a hyperkinetic variant of the hemodynamic response under the short treatment course.
authors.forename: L N
authors.initials: LN
authors.lastname: Eliseeva
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Blednova
authors.forename: Z A
authors.initials: ZA
authors.lastname: Avakimian
authors.forename: A M
authors.initials: AM
authors.lastname: Tkachenko
authors.forename: T A
authors.initials: TA
authors.lastname: Orlova
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D019808:Losartan / Q000008:administration & dosage*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D019808:Losartan