Supportive care in hematologic malignancies: hematopoietic growth factors, infections, transfusion therapy.
A number of recent developments in the supportive care of hematological malignancies have been selected for critical discussion. The first section focuses on the role of evidence-based guidelines in influencing the use of hematopoietic growth factors in medical practice. The next section updates the current clinical status of amifostine (Ethyol, Alza Corp., Palo Alto CA, USA, and US Bioscience, West Conshohocken, PA, USA) the first broad-spectrum cytoprotective agent available. The management of invasive fungal infections and the use of liposomal antifungal agents are reviewed next. Finally, the current status of transfusion support is presented.
Fetscher
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Department of Internal Medicine, Freiburg University Medical Center, Freiburg im Breisgau, Germany.
Mertelsmann
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R
D000328:Adult; D004999:Amifostine / Q000494:pharmacology / Q000627:therapeutic use; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001228:Aspergillosis / Q000517:prevention & control; D001803:Blood Transfusion / Q000706:statistics & numerical data; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D017321:Clinical Trials, Phase I as Topic; D019337:Hematologic Neoplasms / Q000150:complications / Q000628:therapy*; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006801:Humans; D017053:Infection Control; D009503:Neutropenia / Q000209:etiology / Q000628:therapy; D005791:Patient Care; D017410:Practice Guidelines as Topic; D011837:Radiation-Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D012955:Societies, Medical; D065227:Transfusion Reaction
D000935:Antifungal Agents; D016298:Hematopoietic Cell Growth Factors; D011837:Radiation-Protective Agents; D000666:Amphotericin B; D004999:Amifostine