Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains.
In vitro activities of seven fluoroquinolones against 140 clinical Acinetobacter baumannii isolates representing 138 different strain types were determined. The rank order of activity was clinafloxacin > gatifloxacin > levofloxacin > trovafloxacin > gemifloxacin = moxifloxacin > ciprofloxacin. The 31 outbreak-related A. baumannii strains were significantly more resistant than were 109 sporadic strains.
Heinemann
B
B
Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany.
Wisplinghoff
H
H
Edmond
M
M
Seifert
H
H
D000150:Acinetobacter / Q000187:drug effects*; D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D002939:Ciprofloxacin / Q000494:pharmacology; D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial / Q000502:physiology; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D000077735:Gemifloxacin; D005858:Germany / Q000453:epidemiology; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D011804:Quinolines
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D009287:Naphthyridines; D011804:Quinolines; D002939:Ciprofloxacin; D064704:Levofloxacin; C057477:clinafloxacin; C080163:trovafloxacin; D015242:Ofloxacin; D000077734:Gatifloxacin; D000077735:Gemifloxacin; D000077266:Moxifloxacin