Autocrine motility factor receptor expression associates with tumor progression in thymoma.
We assessed the autocrine motility factor receptor (AMFR/gp78) expression in thymoma. AMFR/gp78 antigen was identified in tumor cells in 16 out of 51 (31.4%) thymomas. The AMFR/gp78 expression was closely associated with the stage (I/II vs. III/IV, p<0.0001), pathological subtypes (epithelial vs. other types, p=0.0214), and enhanced expression of alpha-smooth-muscle actin within stroma (p<0. 0001). The outcome of the patients with AMFR/gp78 expression was significantly worse than for those without it (p<0.01). All initial tumors with recurrence expressed AMFR/gp78. The AMFR/gp78 appears to be involved in tumor progression in thymoma.
Ohta
Y
Y
First Department of Surgery, Kanazawa University, School of Medicine, Kanazawa 920-8641, Japan.
Minato
H
H
Tanaka
Y
Y
Go
T
T
Oda
M
M
Watanabe
Y
Y
D000199:Actins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism; D060285:Receptors, Autocrine Motility Factor; D018121:Receptors, Cytokine / Q000378:metabolism*; D016019:Survival Analysis; D013945:Thymoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D013953:Thymus Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D044767:Ubiquitin-Protein Ligases
D000199:Actins; D009363:Neoplasm Proteins; D018121:Receptors, Cytokine; C555000:AMFR protein, human; D060285:Receptors, Autocrine Motility Factor; D044767:Ubiquitin-Protein Ligases