Maternal exposure to trichloroethylene in drinking water and birth-weight outcomes.
An ecological epidemiological study was conducted with data obtained from an environmental dose-reconstruction study and the Arizona Birth Information Tapes. Before 1981, a portion of the city of Tucson water-distribution system was contaminated with trichloroethylene (i.e., < 5 micrograms per liter of water to 107 micrograms per liter of water). Target and comparison populations were selected with a Geographic Information System. Logistical-regression analysis revealed an association between maternal exposure to trichloroethylene via drinking water and very-low-birth-weight babies (i.e., < 1,501 grams) (odds ratio = 3.3; 95% confidence interval = 0.5, 20.6; and Wald chi-square p value = 0.2). No association was found between maternal exposure to trichloroethylene via drinking water and low birth weight or full-term low-birth-weight infants (gestational period > 35 wk and < 46 wk).
Rodenbeck
S E
SE
Division of Health Assessment and Consultation Agency for Toxic Substances and Disease Registry, Public Health Service, US Department of Health and Human Services, Fort Worth, Texas, USA.
Sanderson
L M
LM
Rene
A
A
D001130:Arizona; D001724:Birth Weight / Q000187:drug effects*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D016015:Logistic Models; D018811:Maternal Exposure / Q000009:adverse effects*; D016347:Medical Records Systems, Computerized; D012997:Solvents / Q000009:adverse effects*; D014241:Trichloroethylene / Q000009:adverse effects*; D014874:Water Pollutants, Chemical / Q000009:adverse effects*; D014881:Water Supply
D012997:Solvents; D014874:Water Pollutants, Chemical; D014241:Trichloroethylene