[Biological markers and exposure to asbestos].
Review of published studies clearly demonstrates the absence of value of the CEA, CYFRA21-1 and NSE biomarkers, either alone or combined, for the screening of lung cancer. So far, diagnostic value of other biomarkers, such as p53 tumor suppressor gene or the detection of antibodies raised against receptors encoded by oncogene or against p21 protein (encoded by K-ras oncogne) remains speculative. This justifies that efforts should be reinforced in this field. Similarly, further studies are needed for biomarkers indicative of individual susceptibility to asbestos-related cancers, particularly in the field of P450 cytochromes or glutathione-S-transferase.
Pairon
J C
JC
Service de pneumologie et pathologie professionnelle, CHI de Créteil.
Housset
B
B
D001195:Asbestosis / Q000175:diagnosis*; D015415:Biomarkers; D019363:Cytochrome P-450 CYP1A1; D019389:Cytochrome P-450 CYP2D6; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System; D004781:Environmental Exposure; D006801:Humans
D015415:Biomarkers; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D019363:Cytochrome P-450 CYP1A1; D019389:Cytochrome P-450 CYP2D6