Association of smoking and personality with a polymorphism of the dopamine transporter gene: results from a community survey.
In studies that used mixed volunteer samples, Lerman et al. [1999: Health Psychol 18:14-20] and Sabol et al. [1999: Health Psychol 18:7-13] reported on an association of smoking with a polymorphism of the dopamine transporter gene. We attempted to replicate this association in a nonvolunteer community sample of 861 Caucasians. No associations were found with either smoking initiation or smoking cessation. Sabol et al. [1999] also reported on an association of the dopamine transporter polymorphism with the personality trait of novelty seeking. However, we failed to find any associations with a range of personality traits, including a scale of fun seeking that correlates with novelty seeking. These negative findings suggest that either the original associations are not replicable or that any association is very small.
Jorm
A F
AF
Psychiatric Epidemiology Research Centre, Australian National University, Canberra. Anthony.Jorm@anu.edu.au
Henderson
A S
AS
Jacomb
P A
PA
Christensen
H
H
Korten
A E
AE
Rodgers
B
B
Tan
X
X
Easteal
S
S
D000328:Adult; D000704:Analysis of Variance; D001315:Australia / Q000453:epidemiology; D002352:Carrier Proteins / Q000235:genetics*; D016009:Chi-Square Distribution; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D005106:Exploratory Behavior; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory; D015203:Reproducibility of Results; D012907:Smoking / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism / Q000523:psychology; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D004298:Dopamine