Plasma TAFI antigen variations in healthy subjects.
The Thrombin Activatable Fibrinolysis Inhibitor (TAFI) is a recently described inhibitor of fibrinolysis. The physiological variations of plasma TAFI antigen are not well known. We studied TAFI antigen values in healthy populations with a commercially available kit from Milan Analytica (Switzerland). Broad range of TAFI antigen values (from 41% to 259%) was found in a population of 249 healthy individuals. Gender as well as pregnancy did not influence mean values of TAFI antigen. There was a positive correlation between TAFI antigen and age in female (r = 0.28; p <0.05) but not in male populations. Mean TAFI antigen value of a black African male group [mean +/- SD (range): 87 +/- 23 (39-144%)] was significantly lower than the one of age matched Caucasian men [114 +/- 34 (52-259%)] (p <0.0001). TAFI antigen values were very stable within individuals, they did not significantly vary on day time or at several months period. Thus, in contrast to large inter-individual variations, TAFI antigen levels are quite stable within individuals.
Chetaille
P
P
Laboratory of Hematology, University of Medicine La Timone, Marseille, France.
Alessi
M C
MC
Kouassi
D
D
Morange
P E
PE
Juhan-Vague
I
I
D000328:Adult; D000367:Age Factors; D000368:Aged; D000933:Antifibrinolytic Agents / Q000097:blood / Q000276:immunology; D000941:Antigens / Q000097:blood; D044383:Black People; D025901:Carboxypeptidase B2; D002268:Carboxypeptidases / Q000097:blood / Q000276:immunology*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012016:Reference Values; D012737:Sex Factors; D013997:Time Factors; D044465:White People
D000933:Antifibrinolytic Agents; D000941:Antigens; D002268:Carboxypeptidases; D025901:Carboxypeptidase B2