[In vitro studies on anemia in chronic inflammatory disease: influence of interleukin-6 on human erythropoietin].
The influence of interleukin-6 (Il-6) on human erythropoietic progenitors growth in vitro was evaluated. It was found Il-6 causes approximately 35% inhibition of early BFU-E growth stimulated with erythropoietin, kit ligand and interleukin-3, Il-6 did not inhibit erythroid colony formation by late BFU-E and CFU-E progenitors. This data suggests the role Il-6 as one of inflammatory cytokines in pathogenesis of anemia of chronic disease acting inhibitory at early BFU-E erythroid progenitors level.
Ratajczak
M Z
MZ
Instytutu-Centrum Medycyny Doświadczalnej i Klinicznej PAN, Warszawie.
Ratajczak
J
J
Skorski
T
T
D000740:Anemia / Q000150:complications* / Q000378:metabolism*; D002908:Chronic Disease; D015672:Erythroid Precursor Cells / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D007249:Inflammation / Q000150:complications*; D015850:Interleukin-6 / Q000378:metabolism / Q000494:pharmacology*
D015850:Interleukin-6