title: An imine addition/ring-closing metathesis approach to the spirocyclic core of halichlorine and pinnaic acid.
abstract: [reaction: see text] An approach to the spirocyclic core of halichlorine and pinnaic acid has been designed around an imine allylation/ring-closing metathesis sequence. This sequence has been used to generate several azabicylo[n.5] model systems. A newly reported metathesis catalyst was show to be highly effective for cyclization of these systems.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. dwright@chem.ufl.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Wright
authors.forename: J P
authors.initials: JP
authors.lastname: Schulte II
authors.forename: M A
authors.initials: MA
authors.lastname: Page
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000470:Alkaloids; D013141:Spiro Compounds; C412666:halichlorine; C412665:pinnaic acid