title: Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12.
abstract: The human UBE2L6 gene encodes UbcH8(Kumar), a ubiquitin-conjugating enzyme (E2) highly simliar in primary structure to UbcH7 which is encoded by UBE2L3. Like UBC4 and UBC5 in yeast, these proteins demonstrate functional redundancy. Herein we report the intron/exon structure of UBE2L6. Comparison of the genomic organization of UBE2L6 with UBE2L3 demonstrates that these genes remain highly conserved at the genomic as well as at the protein level. We also describe the chromosomal localization of UBE2L6, which maps to chromosome 11q12.
authors.affiliation: Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Leeds, UK. rmrhca@stjames.leeds.ac.uk
authors.forename: H C
authors.initials: HC
authors.lastname: Ardley
authors.forename: S A
authors.initials: SA
authors.lastname: Rose
authors.forename: N
authors.initials: N
authors.lastname: Tan
authors.forename: J P
authors.initials: JP
authors.lastname: Leek
authors.forename: A F
authors.initials: AF
authors.lastname: Markham
authors.forename: P A
authors.initials: PA
authors.lastname: Robinson
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics; D005091:Exons / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D007438:Introns / Q000235:genetics*; D008025:Ligases / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D020161:Physical Chromosome Mapping; D016415:Sequence Alignment; D044763:Ubiquitin-Conjugating Enzymes
chemical_list: C079437:UBE2L3 protein, human; C471622:UBE2L6 protein, human; D044763:Ubiquitin-Conjugating Enzymes; D008025:Ligases