Study of beta-blockers/beta-cyclodextrins inclusion complex by NMR, DSC, X-ray and SEM investigation.
The formation of inclusion complexes between beta-cyclodextrin with the two beta-blockers, atenolol and celiprolol, have been studied in the aqueous environment and in the solid state by nuclear magnetic resonance (NMR) spectroscopy, X-ray, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) techniques. The magnitude of the chemical shifts of the interior and exterior beta-cyclodextrin protons in the presence of each beta-blocker indicated that these are included within the beta-cyclodextrin cavity. In aqueous solution they form 1:1 complexes. In the solid state the formation of the beta-cyclodextrin/atenolol (celiprolol) complexes is confirmed by X-ray, DSC and SEM, also employed to characterize pure substances and their physical mixtures.
Ficarra
R
R
Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università di Messina, Italy.
Ficarra
P
P
Di Bella
M R
MR
Raneri
D
D
Tommasini
S
S
Calabrò
M L
ML
Gamberini
M C
MC
Rustichelli
C
C
D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D014961:X-Ray Diffraction
D000319:Adrenergic beta-Antagonists