The effect of acute citalopram on extracellular 5-HT levels is not augmented by lithium: an in vivo microdialysis study.
A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentative strategy. Since lithium has been demonstrated to affect 5-HT neurotransmission, we examined the effect of acute and subchronic lithium on 5-HT levels after a challenge with citalopram. We found that subchronic administration of lithium increases extracellular 5-HT baseline level and decreases the extracellular 5-HIAA baseline. However, we found no evidence that the effect of acute citalopram on extracellular 5-HT levels is augmented by acute or subchronic lithium.
Wegener
G
G
Institute for Basic Psychiatric Research, Department of Biological Psychiatry, DK-8240, Risskov, Denmark. wegener@dadlnet.dk
Linnet
K
K
Rosenberg
R
R
Mørk
A
A
D000818:Animals; D015283:Citalopram / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005110:Extracellular Space / Q000187:drug effects* / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D008094:Lithium / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D017551:Microdialysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*
D015283:Citalopram; D012701:Serotonin; D008094:Lithium