title: Hepatitis C virus in monozygotic twins.
abstract: A case of a pregnant patient with chronic hepatitis C who gave birth to monozygotic twins that were infected with HCV is reported. One of the newborns was positive for HCV-RNA in blood sample collected 12 hours after delivery. The other newborn was negative for HCV-RNA at birth, but was detected HCV viremia at three months of age. The results have led to the conclusion that one of the twins was probably contaminated in the intrauterine period, while the other acquired the infection in the perinatal period. Both were negative for HCV-RNA and for anti-HCV in the serum samples collected at nine months of age. The report describes the changes in the laboratory tests conducted in mother and twins until 29 months after delivery.
authors.affiliation: Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, Brasil. flopes@correionet.com.br
authors.forename: F L
authors.initials: FL
authors.lastname: Gonçales
authors.forename: R S
authors.initials: RS
authors.lastname: Stucchi
authors.forename: M H
authors.initials: MH
authors.lastname: Pavan
authors.forename: R N
authors.initials: RN
authors.lastname: Angerami
authors.forename: N S
authors.initials: NS
authors.lastname: Gonçales
mesh_terms: D000328:Adult; D004200:Diseases in Twins; D005260:Female; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000302:isolation & purification; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000821:virology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D014430:Twins, Monozygotic
chemical_list: D018937:Hepatitis C Antibodies