title: SRPrises in RNA-protein recognition.
abstract: The recent structure determination of the phylogenetically conserved cor re of the signal recognition particle (SRP) reveals a novel of highly un usual RNA-protein interface, where non-canonical base pairs play a centr al role. The structure shows how a helix-turn-helix motif can be employ ed to bind RNA and offers hints as to how the signal peptide is recogniz ed by the SRP.
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
authors.forename: P B
authors.initials: PB
authors.lastname: Rupert
authors.forename: A R
authors.initials: AR
authors.lastname: Ferré-D'amaré
mesh_terms: D019077:Helix-Turn-Helix Motifs / Q000502:physiology; D008958:Models, Molecular; D011485:Protein Binding / Q000235:genetics* / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D012313:RNA / Q000378:metabolism*; D018271:Signal Recognition Particle / Q000378:metabolism*
chemical_list: D018271:Signal Recognition Particle; D012313:RNA