title: The first, second, third and fourth order Markov chain analysis on the amino-acid sequence of human dopamine beta-hydroxylase.
abstract: The repeated amino-acid sequences in human dopamine beta-hydroxylase (DBH) may be indispensable for DBH activity, because such repetitions cannot be simply attributed to random chance. The amino acid sequence of human DBH was analysed according to two-, three-, four- and five-amino-acid sequences and their probabilities in human DBH were calculated. The first, second, third and fourth order Markov chain was used to calculate the transition probability for two-, three-, four- and five-amino-acid sequences. The longest repeated sequence is glycine-isoleucine-leucine-glutamic acid-glutamic acid, which appears twice in DBH. The results suggest that the amino acids with a high Markov transition probability may serve as the potential targets of new drugs, because they are unlikely to change into other amino acids.
authors.affiliation: Biochemistry Section, Department of Basic Medicine, National Institute for Minamata Disease, Minamata, Kumamoto 867, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Wu
mesh_terms: D000595:Amino Acid Sequence; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D006801:Humans; D008390:Markov Chains; D008957:Models, Genetic; D012559:Schizophrenia / Q000235:genetics
chemical_list: D004299:Dopamine beta-Hydroxylase