[Role of cytokine signaling in cardiomyopathy].
Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocyte via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besides various well-established mechanisms by which myocardial hypertrophy and remodeling are regulated, a gp130 signaling may be a newly discovered mechanism that regulates these events in association with cytoprotective effect in cardiomyopathy. In addition, the activation of gp130 dependent signaling pathway in cardiac myocytes might play a pivotal role in the prevention of heart failure.
Takihara
K
K
Department of Molecular Medicine, Osaka University Medical School.
D000818:Animals; D017209:Apoptosis; D009202:Cardiomyopathies / Q000209:etiology*; D016207:Cytokines / Q000502:physiology*; D006333:Heart Failure / Q000517:prevention & control; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D009025:Morpholines / Q000378:metabolism; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D016207:Cytokines; D009025:Morpholines; C005759:2-phenyl-5,5-dimethyltetrahydro-1,4-oxazine