Itraconazole lung concentrations in haematological patients.
Itraconazole distribution is largely dependent on its high liposolubility. Intrapulmonary lung concentrations remain unknown in haematological patients. We report itraconazole lung concentrations in such patients treated with itraconazole. Itraconazole and hydroxyitraconazole were measured by high-performance liquid chromatography in concomitant blood samples and lung post-mortem biopsies (three cases) or lung lobectomy (one case). These itraconazole and metabolite lung concentrations were sufficient to be active on Aspergillus.
Coronel
B
B
Intensive Care Unit, Edouard Herriot Hospital, Lyon, France. coronel@lyon.fnclcc.fr
Levron
J C
JC
Dorez
D
D
Van Devenne
A
A
Archimbaud
E
E
Mercatello
A
A
D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D005260:Female; D019337:Hematologic Neoplasms / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D017964:Itraconazole / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; C084794:hydroxyitraconazole; D017964:Itraconazole