Serial position effect and selective amnesia induced by scopolamine in mice.
Mice were trained to run through a maze with six gates, each consisting of three doors--two locked and one unlocked. They learned to choose a correct (unlocked) door at the gates close to the beginning and end better than in the middle, showing the primacy and recency effects of serial learning. A low dose of scopolamine unexpectedly enhanced the primacy effect, while a high dose impaired learning in general. The enhancement of the primacy effect can be explained in terms of reduction of retroactive interference.
Watanabe
S
S
Department of Psychology, Keio University.
Yanagisawa
N
N
D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000494:pharmacology*; D012601:Scopolamine / Q000009:adverse effects / Q000494:pharmacology*; D012691:Serial Learning / Q000187:drug effects*
D018727:Muscarinic Antagonists; D012601:Scopolamine