Corticotropin releasing hormone: therapeutic implications and medicinal chemistry developments.
Corticotropin releasing hormone (CRH, sometimes known as CRF) is an endogenous 41 amino acid peptide that has been implicated in the onset of pregnancy, the 'fight or flight' response, in addition to a large number of physiological disorders. Recently, medicinal chemists have developed a number of potent and selective compounds that show promise in a vast array of therapeutic uses. Herein we review the current status of research.
Keller
P A
PA
Department of Chemistry, The University of Wollongong, NSW, Australia. paul_keller@uow.edu.au
Elfick
L
L
Garner
J
J
Morgan
J
J
McCluskey
A
A
D000595:Amino Acid Sequence; D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D011247:Pregnancy; D018019:Receptors, Corticotropin-Releasing Hormone / Q000145:classification / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D018019:Receptors, Corticotropin-Releasing Hormone; D003346:Corticotropin-Releasing Hormone