title: Serum alpha-fetoprotein levels in Beckwith-Wiedemann syndrome.
abstract: We conducted a retrospective study that compared serial alpha-fetoprotein (AFP) concentrations obtained from 22 children with Beckwith-Wiedemann syndrome (BWS) with levels established for healthy children. The AFP concentration is greater in patients with BWS and declines during the postnatal period at a significantly slower rate than what is reported in healthy children. AFP levels obtained in the course of routine tumor screening in children with BWS should be interpreted with a normal curve established specifically for BWS rather than with previously published data for healthy infants and children.
authors.affiliation: Department of Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, OH 44106-6506, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Everman
authors.forename: C
authors.initials: C
authors.lastname: Shuman
authors.forename: B
authors.initials: B
authors.lastname: Dzolganovski
authors.forename: M A
authors.initials: MA
authors.lastname: O'riordan
authors.forename: R
authors.initials: R
authors.lastname: Weksberg
authors.forename: N H
authors.initials: NH
authors.lastname: Robin
mesh_terms: D001506:Beckwith-Wiedemann Syndrome / Q000097:blood*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins