Candida arthritis in a premature infant treated successfully with oral fluconazole for six months.
BACKGROUND
Candida arthritis in premature infants is a rare condition mainly treated with parenteral amphotericin B.


METHODS
Arthritis 9 weeks after birth. The infection resulted out of colonisation at birth and fungaemia at day 6 and day 13 of life.


METHODS
Oral fluconazole for 6 months (5 mg/kg/day after loading with 7 mg/kg/day).


RESULTS
Full remission.


CONCLUSIONS
Oral fluconazole is an alternative to parenteral amphotericin B in the treatment of premature infants, but proof of absorption and an extended treatment period according to prematurity might be warranted.
Weigl
J A
JA
Klinik für Allgemeine Pädiatrie, Kiel, Germany. weigl@pediatrics.uni-kiel.de
D000284:Administration, Oral; D000935:Antifungal Agents / Q000627:therapeutic use*; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000188:drug therapy*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy*; D004334:Drug Administration Schedule; D015725:Fluconazole / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome
D000935:Antifungal Agents; D015725:Fluconazole