title: Spillover in the spotlight.
abstract: Fast neurotransmission in the brain is typically mediated by local actions of transmitters at ionotropic receptors within synaptic contacts. Recent studies now reveal that, in addition to point-to-point signaling, amino-acid transmitters mediate diffuse signaling at extrasynaptic metabotropic receptors.
authors.affiliation: Department of Neuroscience, University of California, San Diego, La Jolla 92093-0608, USA. jisaacson@ucsd.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Isaacson
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology; D018698:Glutamic Acid / Q000502:physiology; D018079:Receptors, GABA / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D018079:Receptors, GABA; D018094:Receptors, Metabotropic Glutamate; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid