Dominant role of the C-terminal domain in the binding of apolipoprotein(a) to the protein core of proteoglycans and other members of the vascular matrix.
The C-terminal domain of apolipoprotein(a) binds in vitro to the protein core of proteoglycans as well as fibrinogen and fibronectin, suggesting that this domain plays a role in anchoring lipoprotein(a) or free apolipoprotein(a) to the vascular subendothelial matrix.
Scanu
A M
AM
Department of Medicine, University of Chicago, IL 60637, USA.
Edelstein
C
C
Klezovitch
O
O
D001054:Apolipoproteins A / Q000737:chemistry* / Q000378:metabolism*; D001161:Arteriosclerosis / Q000378:metabolism; D001665:Binding Sites; D004730:Endothelium, Vascular / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D011489:Protein Denaturation; D011509:Proteoglycans / Q000737:chemistry* / Q000378:metabolism*
D001054:Apolipoproteins A; D005353:Fibronectins; D011509:Proteoglycans; D005340:Fibrinogen