title: Study of beta-blockers/beta-cyclodextrins inclusion complex by NMR, DSC, X-ray and SEM investigation.
abstract: The formation of inclusion complexes between beta-cyclodextrin with the two beta-blockers, atenolol and celiprolol, have been studied in the aqueous environment and in the solid state by nuclear magnetic resonance (NMR) spectroscopy, X-ray, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) techniques. The magnitude of the chemical shifts of the interior and exterior beta-cyclodextrin protons in the presence of each beta-blocker indicated that these are included within the beta-cyclodextrin cavity. In aqueous solution they form 1:1 complexes. In the solid state the formation of the beta-cyclodextrin/atenolol (celiprolol) complexes is confirmed by X-ray, DSC and SEM, also employed to characterize pure substances and their physical mixtures.
authors.affiliation: Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università di Messina, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Ficarra
authors.forename: P
authors.initials: P
authors.lastname: Ficarra
authors.forename: M R
authors.initials: MR
authors.lastname: Di Bella
authors.forename: D
authors.initials: D
authors.lastname: Raneri
authors.forename: S
authors.initials: S
authors.lastname: Tommasini
authors.forename: M L
authors.initials: ML
authors.lastname: Calabrò
authors.forename: M C
authors.initials: MC
authors.lastname: Gamberini
authors.forename: C
authors.initials: C
authors.lastname: Rustichelli
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D014961:X-Ray Diffraction
chemical_list: D000319:Adrenergic beta-Antagonists