title: The CD4(+) T cell response to HIV-1.
abstract: Although virus-specific CD4(+) T cells have proven to be a critical component of the immunologic control of chronic viral infections in a number of models, the role and even the existence of HIV-1-specific CD4(+) T cells in human HIV-1 infection has been controversial. Recent advances in quantifying and functionally characterizing HIV-1-specific T cells may shed light on the participation of these cells in anti-HIV-1 host defense.
authors.affiliation: Vaccine and Gene Therapy Institute, Oregon Health Sciences University, Mail Code L220, Portland, OR 97201-3098, USA. pickerl@ohsu.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Picker
authors.forename: V C
authors.initials: VC
authors.lastname: Maino
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans
chemical_list: D019380:Anti-HIV Agents