Guest and subunit exchange in self-assembled ionophores.
[reaction: see text] Self-assembled ionophores, formed by hydrogen bonding of isoG 1 around a cation, are dynamic structures. Multinuclear NMR spectroscopy in CD(3)CN-CDCl(3) showed that cation exchange is >10(4) faster than exchange of isoG 1 ligand in (isoG 1)(10)-Cs(+) Ph(4)B(-). The cationic guest also affected the kinetic stability of the complex. 2D-EXSY NMR experiments in CDCl(3) showed that ligand exchange was 2 orders of magnitude faster for the Li(+)-decamer than for the Cs(+)-decamer.
Cai
M
M
Department of Chemistry and Biochemistry, University of Maryland, College Park 20742, USA.
Sidorov
V
V
Lam
Y F
YF
Flowers
R A
RA
Davis
J T
JT
D002412:Cations / Q000378:metabolism; D006151:Guanosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D006860:Hydrogen Bonding; D017136:Ion Transport; D007476:Ionophores / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure
D002412:Cations; D007476:Ionophores; D008024:Ligands; D006151:Guanosine