title: The impact of early initiation of highly active antiretroviral therapy on the human immunodeficiency virus type 1-specific CD8 T cell response in children.
abstract: This cross-sectional study investigated the effect of early highly active antiretroviral therapy (HAART) on human immunodeficiency virus (HIV) type 1-specific CD8 T cell responses in children. HIV-1-specific CD8 T cell responses were quantified using an enzyme-linked immunospot assay to measure interferon-gamma-secreting cells. HIV-1-infected children were classified by time of HAART initiation prior to age 1 year or after age 2 years as early (n=24) or late (n=28) treated. The magnitude and breadth of the HIV-1-specific CD8 T cell response was significantly lower in children receiving early compared with late HAART treatment (P=.0007 and.0001, respectively). However, total CD8 T cell responses in the early HAART treatment group did not differ significantly from those of age-matched non-HAART-treated controls (n=30). Thus, the reduced magnitude and breadth of the HIV-1-specific CD8 T cell response in early HAART-treated children is due to their younger age.
authors.affiliation: Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY 10016, USA. hspiegel@adarc.org hspiegel@adarc.org
authors.forename: H M
authors.initials: HM
authors.lastname: Spiegel
authors.forename: R
authors.initials: R
authors.lastname: Chandwani
authors.forename: M E
authors.initials: ME
authors.lastname: Sheehy
authors.forename: J
authors.initials: J
authors.lastname: Dobroszycki
authors.forename: G
authors.initials: G
authors.lastname: Fennelly
authors.forename: A
authors.initials: A
authors.lastname: Wiznia
authors.forename: J
authors.initials: J
authors.lastname: Radding
authors.forename: M
authors.initials: M
authors.lastname: Rigaud
authors.forename: H
authors.initials: H
authors.lastname: Pollack
authors.forename: W
authors.initials: W
authors.lastname: Borkowsky
authors.forename: M
authors.initials: M
authors.lastname: Rosenberg
authors.forename: D F
authors.initials: DF
authors.lastname: Nixon
mesh_terms: D000293:Adolescent; D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007223:Infant
chemical_list: D019380:Anti-HIV Agents