title: [Intra- and postoperative heart rate changes following propofol anesthesia; a comparison with isoflurane anesthesia].
abstract: Bradycardia during propofol anesthesia is well known, but bradycardia after propofol anesthesia has not been studied well. We compared perioperative heart rates in patients who had undergone gynecological surgery under lumbar epidural anesthesia supplemented with light general anesthesia using isoflurane and nitrous oxide in oxygen (Group Iso, n = 25) with those who had received lumbar epidural anesthesia supplemented with propofol (Group Prop, n = 25). The heart rates for the Group Prop were significantly lower (P < 0.05) than those for the Group Iso after the induction of anesthesia up to 2 hours after surgery. Two patients in the Group Prop developed bradycardia below 50 bpm 1 and 2 hours after surgery. In one of them intravenous atropine was necessary to treat bradycardia. We conclude that more attention should be paid to postoperative as well as intraoperative bradycardia in patients who receive propofol.
authors.affiliation: Department of Anesthesiology, Fukuoka University Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Shinokuma
authors.forename: K
authors.initials: K
authors.lastname: Seo
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: S
authors.initials: S
authors.lastname: Kawashima
authors.forename: K
authors.initials: K
authors.lastname: Muranaka
authors.forename: H
authors.initials: H
authors.lastname: Miyawaki
mesh_terms: D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D001919:Bradycardia / Q000139:chemically induced*; D005260:Female; D013509:Gynecologic Surgical Procedures; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007432:Intraoperative Period; D007530:Isoflurane / Q000009:adverse effects*; D009609:Nitrous Oxide; D011184:Postoperative Period; D015742:Propofol / Q000009:adverse effects*
chemical_list: D007530:Isoflurane; D009609:Nitrous Oxide; D015742:Propofol