Endoplasmic reticulum-associated protein degradation.
The quality control system in the endoplasmic reticulum of eukaryotic cells ensures that newly synthesized proteins that fail to fold into the correct conformation or unassembled orphan subunits of oligomeric proteins are rapidly eliminated by proteolytic degradation. This entails the export of proteins from the endoplasmic reticulum to the cytosol followed by their destruction by the cytosolic ubiquitin/proteasome pathway. While this mechanism effectively prevents the cellular accumulation of non-functional or unwanted endogenous proteins, it renders the cell vulnerable to certain viruses and toxins that are able to subvert this degradative mechanism for their own advantage.
Lord
J M
JM
Department of Biological Sciences, University of Warwick, Coventry, UK.
Davey
J
J
Frigerio
L
L
Roberts
L M
LM
D001343:Autophagy; D003546:Cysteine Endopeptidases / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D018832:Molecular Chaperones / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D017510:Protein Folding; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D012276:Ricin / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism; D014764:Viral Proteins / Q000378:metabolism
D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D018832:Molecular Chaperones; D009097:Multienzyme Complexes; D011506:Proteins; D014452:Ubiquitins; D014764:Viral Proteins; D012276:Ricin; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex