Morin hydrate: a potential antioxidant in minimizing the free-radicals-mediated damage to cardiovascular cells by anti-tumor drugs.
The co-incubation of morin hydrate with either doxorubicin or mitomycin C could minimize the toxicity of these anti-tumor drugs on cardiovascular cells, such as red blood cells, human umbilical vein endothelial cells (ECV304) and primary mouse cardiomyocytes, whereas morin hydrate did not lower the cytotoxicity of the drugs on human hepatocellular carcinoma cells (HepG2). Morin hydrate may not exert its antioxidant effect by enhancing the antioxidant enzymatic activity because it did not cause any induction on the mRNA levels of manganese superoxide dismutase expression in ECV304 cells and HepG2 cells.
Kok
L D
LD
Department of Biochemistry, The Chinese University of Hong Kong, New Territories, Hong Kong Special Administrative Region.
Wong
Y P
YP
Wu
T W
TW
Chan
H C
HC
Kwok
T T
TT
Fung
K P
KP
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects*; D004317:Doxorubicin / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D004912:Erythrocytes / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D005609:Free Radicals / Q000633:toxicity; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D051379:Mice; D016685:Mitomycin / Q000633:toxicity*; D009206:Myocardium / Q000166:cytology; D012333:RNA, Messenger / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics; D014407:Tumor Cells, Cultured; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D047309:Flavones
D000975:Antioxidants; D004317:Doxorubicin; D005419:Flavonoids; D005609:Free Radicals; D016685:Mitomycin; D012333:RNA, Messenger; D013482:Superoxide Dismutase; C008548:morin; D047309:Flavones