[Use of midodrine and frozen semen to treat semen transport disturbances. Report of 2 cases].
Retrograde ejaculation severely compromises male fertility. The use of sympathicomimetics for the treatment of this condition has poor results, except in patients with partial retrograde ejaculation, whose semen has a higher spermatozoa concentration. The semen of two patients with partial retrograde ejaculation was collected and frozen after the injection of a sympathicomimetic (Midodrine). The frozen/thawed samples were mixed with fresh semen recently ejaculated to obtain a minimal number of motile spermatozoa, and used for intrauterine insemination (> de 1 x 10(6) motile spermatozoa/ml). In both cases, pregnancies that developed satisfactorily, were obtained.
Sánchez
R
R
Departamento de Ciencias Preclínicas, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile. rsanchez@ufro.cl
Peña
P
P
Villagrán
E
E
D000328:Adult; D004542:Ejaculation / Q000502:physiology; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000209:etiology; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D008879:Midodrine / Q000627:therapeutic use*; D012662:Semen Preservation / Q000379:methods*; D013081:Sperm Motility / Q000187:drug effects; D013083:Sperm Transport / Q000502:physiology; D013566:Sympathomimetics / Q000627:therapeutic use*
D013566:Sympathomimetics; D008879:Midodrine