Growth factor regulation of the cell cycle in developing and mature inner ear sensory epithelia.
Growth factors and other extracellular signals regulate cell division in many tissues. Consequently, growth factors may have therapeutic uses to stimulate the production of replacement sensory hair cells in damaged human inner ears, thereby assisting in alleviating hearing loss and vestibular dysfunction. Assessment of the ability of growth factors to stimulate cell proliferation in inner ear sensory epithelia is at an early stage. This paper provides a brief account of what we know regarding growth factor regulation of cell proliferation in developing and mature inner ear sensory epithelia.
Oesterle
E C
EC
Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA, USA.
Hume
C R
CR
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D007758:Ear, Inner / Q000166:cytology* / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism* / Q000494:pharmacology; D006198:Hair Cells, Auditory / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D017978:Receptors, Growth Factor / Q000378:metabolism
D006133:Growth Substances; D017978:Receptors, Growth Factor; D018844:Cyclin-Dependent Kinases