[Hypersensitivity syndrome : a rare but severe adverse effect of antithyroid drugs].
We report the case of a female patient with a severe hypersensitivity syndrome caused by carbimazole. She was treated for Graves' disease for a few weeks when she was referred for skin rash, increased liver enzymes and hypereosinophilia. No immunological abnormalities were detected. Discontinuation of carbimazole resulted in quick recovery. Pathogenesis of the hypersensitivity syndrome is discussed. Antithyroid drugs are rarely involved in the syndrome but cases with vasculitis have been described. In our patient, the role of excessive dose is possible.
Vinzio
S
S
Service de Médecine Interne et Nutrition, Hôpital de Hautepierre, 67098 Strasbourg Cedex, France. bernard.goichot@chru-strasbourg.fr
Goichot
B
B
Andrès
E
E
Schlienger
J L
JL
D000368:Aged; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002231:Carbimazole / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity; D005260:Female; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans
D013956:Antithyroid Agents; D002231:Carbimazole