Innervation pattern of substance P- and calcitonin gene-related peptide-immunoreactive nerves of the cerebral arteries in the quail.
The pattern of cerebrovascular substance P (SP)- and calcitonin gene-related peptide (CGRP)-immunoreactive (IR) innervation was investigated in the quail. SP- and CGRP-IR nerves were relatively a few in the rostral part of the anterior circulation, and very scanty or lacking in its caudal part and the whole of the posterior circulation. A significant finding was that the anterior circulation in the majority of individuals is furnished with a varying proportion of SP-IR nerves with or without CGRP immunoreactivity. There was a good correlation in the expression of CGRP immunoreactivity between SP-IR cells in the ophthalmic division of the trigeminal ganglion and SP-IR nerves supplying the major cerebral arteries. In the quail, SP- and CGRP-IR fiber bundles are usually present in the internal ethmoidal artery (IEA). From these and other findings, it is most probable that cerebral perivascular SP- and CGRP-IR nerves are mainly derived from the same categories of neurons in the primary sensory ganglion via the IEA. The close association of varicose SP-IR axons to the nerve cells in the pial arteries suggests that these intrinsic neurons may play some vasocontrolling roles through the modulatory effect of their pericellular SP-IR axons.
Kusaba
H
H
Muromi Animal Hospital, Fukuoka, Japan.
Ando
K
K
Fujihara
N
N
D000818:Animals; D000911:Antibodies, Monoclonal; D001921:Brain / Q000033:anatomy & histology* / Q000098:blood supply; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis / Q000502:physiology*; D002536:Cerebral Arteries / Q000294:innervation*; D003370:Coturnix / Q000033:anatomy & histology*; D003391:Cranial Nerves / Q000098:blood supply / Q000737:chemistry / Q000502:physiology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D007150:Immunohistochemistry; D008297:Male; D013373:Substance P / Q000032:analysis / Q000502:physiology*
D000911:Antibodies, Monoclonal; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide