[Mechanisms of the optimization of oxygen metabolism under the effects of mafusol and mildronate during emergency implantation of hip prosthesis].
The results of using antihypoxants Mafusol and Mildronate in the course of emergency endoprosthesis of the hip joint were analyzed in 41 patients at the age of (80.5 +/- 5.6) years with fractures of the proximal part of the femoral bone. The authors noted optimization of the organism oxygen budget under the influence of the drugs, its physiological mechanisms being deciphered. The protective properties of these drugs manifested themselves in lower consumption of oxygen by the tissues with greater possibilities of its release by oxyhemoglobin as well as in the lessening of intrapulmonary shunting and prevention of the development of metabolic acidosis.
Stebleva
T F
TF
Voĭtovich
A V
AV
Mamaeva
E G
EG
Lapshangskaia
E E
EE
Semigolovskiĭ
N Iu
NIu
Lebedinskiĭ
K M
KM
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000138:Acidosis / Q000517:prevention & control; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D005561:Formates / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology*; D006620:Hip Fractures / Q000601:surgery; D006801:Humans; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects
D000276:Adjuvants, Immunologic; D005561:Formates; D006490:Hemostatics; D008763:Methylhydrazines; C030544:formic acid; C050147:3-(2,2,2-trimethylhydrazine)propionate; D010100:Oxygen