The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1.
Virus-specific CD4(+) T cell help and CD8(+) cytotoxic T cell (CTL) responses are critical for the maintenance of effective immunity in chronic viral infections. HIV-1 infection presents a unique situation in which HIV-1-specific T helper cell responses are characteristically impaired and virus-specific CTLs wane over time as disease progresses; a relationship exists between T cell help and CTL responses in HIV-1 infection.
Altfeld
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Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA. Maltfeld@partners.org
Rosenberg
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D000818:Animals; D004195:Disease Models, Animal; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology