Lack of utility of specific immunoglobulin G antibody avidity for serodiagnosis of reactivated toxoplasmosis in immunocompromised patients.
The avidities of Toxoplasma-specific immunoglobulin G serum antibodies were measured in immunocompromised patients presenting with cerebral or extracerebral toxoplasmosis and/or serological reactivation. Since avidity remained high and stable in 39 of 40 patients with toxoplasmosis and 27 of 28 patients with serological reactivation, we conclude that this test cannot help diagnose toxoplasmosis in these patients.
Mechain
B
B
Laboratoire de Parasitologie-Mycologie, Hôpital Saint-Louis, 75475 Paris Cedex 10, France.
Garin
Y J
YJ
Robert-Gangneux
F
F
Dupouy-Camet
J
J
Derouin
F
F
D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis / Q000276:immunology*; D000915:Antibody Affinity; D000918:Antibody Specificity; D006801:Humans; D016867:Immunocompromised Host; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology; D012680:Sensitivity and Specificity; D012698:Serologic Tests; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000175:diagnosis* / Q000276:immunology*
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G