CNS granulomatosis in a child with chronic granulomatous disease.
Chronic granulomatous disease (CGD) is a disease in which a granulomatous process involves various organ systems and in which recurrent infections are seen. The basic defect is the absence of the granulocyte respiratory burst. CNS involvement is rare. We present a report of a child with CGD and CNS involvement, presenting with hydrocephalus. Candida was identified in the granulomata. The patient responded well to a CSF shunt and antifungal therapy.
Agus
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Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel.
Spektor
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Israel
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D001927:Brain Diseases / Q000209:etiology* / Q000601:surgery; D002177:Candidiasis / Q000209:etiology*; D002557:Cerebrospinal Fluid Shunts; D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000601:surgery; D006801:Humans; D008297:Male; D016921:Meningitis, Fungal / Q000209:etiology*