title: Effects of the dose of Ehrlichia phagocytophila on the severity of experimental infections in lambs.
abstract: Twenty-one lambs were used to investigate whether their response to an infection with Ehrlichia phagocytophila was dose-dependent Four groups of four lambs were infected intravenously with a dilution in physiological saline of E phagocytophila-infected sheep blood containing either 1.3 x 10(5) infected cells, or approximately 43 infected cells, 4.3 infected cells, or 1.3 infected cells (mean values) and four lambs were left uninfected. The incubation period was significantly shorter in the lambs infected with the highest dose of E phagocytophila. However, the clinical and haematological changes observed, and the weekly weight gains of the lambs were independent of the dose of E phagocytophila. As little as one Ephagocytophila infected cell may be enough to transmit the infection.
authors.affiliation: Department of Sheep and Goat Research, Norwegian School of Veterinary Science, Sandnes.
authors.forename: S
authors.initials: S
authors.lastname: Stuen
authors.forename: K
authors.initials: K
authors.lastname: Artursson
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000097:blood; D004198:Disease Susceptibility / Q000662:veterinary; D004306:Dose-Response Relationship, Immunologic; D004536:Ehrlichia / Q000276:immunology / Q000472:pathogenicity*; D016873:Ehrlichiosis / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000276:immunology / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial