title: Histone macroH2A1.2 is concentrated in the XY compartment of mammalian male meiotic nuclei.
abstract: We show here that histone macroH2A1.2 concentrates at the transcriptionally silent XY body, normally being formed during male meiosis in the mouse. A similar accumulation has earlier been observed on the inactive X chromosomes of somatic adult female mammalian cells by Costanzi and Pehrson (1998). This correspondence in the nature of heterochromatinization of the X chromosomes in males and females adds another property of X chromosome inactivation that is shared by males and females at different phases of their life cycle.
authors.affiliation: Department of Genetics, The Hebrew University, Jerusalem, Israel. carmeli@mial.ls.huji.ac.il
authors.forename: C
authors.initials: C
authors.lastname: Richler
authors.forename: S K
authors.initials: SK
authors.lastname: Dhara
authors.forename: J
authors.initials: J
authors.lastname: Wahrman
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism; D004303:Dosage Compensation, Genetic; D005260:Female; D006570:Heterochromatin / Q000235:genetics* / Q000378:metabolism; D006657:Histones / Q000235:genetics*; D008297:Male; D008540:Meiosis / Q000235:genetics*; D051379:Mice; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D012730:Sex Chromosomes / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism
chemical_list: D006570:Heterochromatin; D006657:Histones; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D014157:Transcription Factors; C077885:XIST non-coding RNA; C120756:macroH2A histone