Reduction of dyskinesia and induction of akinesia induced by morphine in two parkinsonian patients with severe sciatica.
In two patients with Parkinson's disease and L-Dopa induced dyskinesia we administered morphine orally to alleviate lumboradicular pain unresponsive to any other form of treatment. Besides an alleviation of the pain both patients showed a decrease in dyskinetic movements at very low doses of morphine and an increase in akinesia at higher doses. This observation indicates a modulation of basal ganglia output by morphine with the possibility of reducing L-Dopa induced dyskinesia in patients treated with morphine for pain.
Berg
D
D
Department of Neurology, University of Würzburg, Federal Republic of Germany.
Becker
G
G
Reiners
K
K
D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000978:Antiparkinson Agents / Q000009:adverse effects; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D006801:Humans; D018476:Hypokinesia / Q000139:chemically induced; D007405:Intervertebral Disc Displacement / Q000150:complications; D007980:Levodopa / Q000009:adverse effects; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000188:drug therapy*; D012585:Sciatica / Q000188:drug therapy*
D000701:Analgesics, Opioid; D000978:Antiparkinson Agents; D007980:Levodopa; D009020:Morphine