title: The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans.
abstract: An essential aspect of a neuron's identity is the pattern of its axonal projections. In C. elegans, axons extend either longitudinally or circumferentially in response to distinct molecular cues, some of which have been identified. It is currently unclear, however, how the differential capacity to respond to these cues is transcriptionally implemented in distinct neuronal subtypes. Here, we characterise a C. elegans paired-like homeobox gene, CePhox2/ceh-17, expressed in five head neurons, ALA and the 4 SIAs, all of which project axons towards the tail along the lateral and sublateral cords. Abrogation of ceh-17 function, while leaving intact many phenotypic traits of these neurons, disrupts their antero-posterior axonal elongation beyond the mid-body region. Conversely, ectopic expression of ceh-17 in the mechanoreceptors, several of which are known to pioneer their tract, leads to exaggerated longitudinal axonal outgrowth. Thus, ceh-17 is a novel gene involved in fasciculation-independent longitudinal axonal navigation.
authors.affiliation: Laboratoire de Génétique et Physiologie du Développement, Developmental Biology Institute of Marseille, CNRS/INSERM/Université de la Méditerranée/AP de Marseille, Luminy Case 907, France.
authors.forename: N
authors.initials: N
authors.lastname: Pujol
authors.forename: P
authors.initials: P
authors.lastname: Torregrossa
authors.forename: J J
authors.initials: JJ
authors.lastname: Ewbank
authors.forename: J F
authors.initials: JF
authors.lastname: Brunet
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001369:Axons; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000235:genetics / Q000254:growth & development*; D029742:Caenorhabditis elegans Proteins; D003001:Cloning, Molecular; D018509:DNA, Helminth; D017353:Gene Deletion; D017238:Genes, Helminth; D005801:Genes, Homeobox; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D029742:Caenorhabditis elegans Proteins; D018509:DNA, Helminth; D015801:Helminth Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; C501507:ceh-17 protein, C elegans