Effects of serotonergic agents on the transport response in rats.
In two experiments, researchers investigated the effects of manipulating serotonin systems on the transport response and dorsal immobility response in developing rats. In Experiment 1, administration of ketanserin and cinanserin, but not metergoline, suppressed the transport response in 23-day-old rats. These agents were without effect on dorsal immobility durations. In Experiment 2, administration of quipazine to 30-, 40-, and 50-day-old rats resulted in significant increases in transport response intensities and dorsal immobility durations. Results are discussed with respect to the nature of the transport response.
Wilson
C
C
Department of Psychology and Department of Chemistry, Sam Houston State University, Huntsville, TX 77341, USA.
Pulido
M
M
D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D002928:Cinanserin / Q000494:pharmacology; D005260:Female; D006128:Growth / Q000187:drug effects; D007650:Ketanserin / Q000494:pharmacology; D008711:Metergoline / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D011814:Quipazine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018490:Serotonin Agents / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D018490:Serotonin Agents; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D008711:Metergoline; D011814:Quipazine; D007650:Ketanserin; D002928:Cinanserin