Stabilization of chromium(V) species in bovine serum albumin adduct.
A detailed investigation of molecular interactions of the protein bovine serum albumin (BSA) with potassium dichromate has been made. Compelling evidence for the formation of a relatively stable Cr(V) species which decays only slowly to afford Cr(III) products has been obtained. The resulting final chromium(III) product mediates in cross-linking of BSA. The implications of the formation of a relatively stable chromium(V) as well as chromium(III)-mediated cross-links in the marker protein are discussed in the context of the metal ion-induced biotoxicity.
Ananth
K M
KM
Chemical Laboratory, Central Leather Research Institute, Adyar, Chennai, 600 020, India.
Rajaram
R
R
Ramasami
T
T
D000818:Animals; D002417:Cattle; D002857:Chromium / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D004591:Electrophoresis, Polyacrylamide Gel; D012710:Serum Albumin, Bovine / Q000737:chemistry*
D002857:Chromium; D012710:Serum Albumin, Bovine