title: Variation in STR loci of the human myelin basic protein gene: north Portugal and São Tomé e Príncipe.
abstract: Allele frequencies and a single-base substitution polymorphism for 3 short tandem repeat (STR) loci of the human myelin basic protein (MBP) gene were evaluated in North Portugal and São Tomé e Príncipe. Strong linkage disequilibrium between loci MBPB and MBPC was found. However, the patterns of nonrandom allelic associations were very different in the 2 populations: levels of haplotypic diversity and heterozygosity were higher in the São Tomé population. Similarly, a difference in the frequency of base substitution G-->A at position 124 was found: the frequency reached 4.1% in North Portugal and 0.5% in São Tomé. In both populations it was always found to be associated with haplotypes B10/C11 and B12/C9.
authors.affiliation: Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), Portugal.
authors.forename: L
authors.initials: L
authors.lastname: Pereira
authors.forename: L
authors.initials: L
authors.lastname: Gusmão
authors.forename: M J
authors.initials: MJ
authors.lastname: Prata
authors.forename: P
authors.initials: P
authors.lastname: Mota
authors.forename: M J
authors.initials: MJ
authors.lastname: Trovoada
authors.forename: A
authors.initials: A
authors.lastname: Amorim
mesh_terms: D000483:Alleles; D005260:Female; D014644:Genetic Variation; D005828:Genetics, Population; D016701:Guinea; D006801:Humans; D008297:Male; D004676:Myelin Basic Protein / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011174:Portugal; D011336:Probability; D020080:Tandem Repeat Sequences / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D004676:Myelin Basic Protein