Synthesis and biological properties of new 1beta-methylcarbapenems having tetrazolothioether moiety.
The synthesis and biological activities of a series of new 1beta-methylcarbapenems 1a-l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem.
Shin
K J
KJ
Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, South Korea.
Koo
K D
KD
Yoo
K H
KH
Kim
D C
DC
Kim
D J
DJ
Park
S W
SW
D000818:Animals; D015780:Carbapenems / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D015780:Carbapenems