[The influence of obesity on ovarian function. II. Plasma leptin concentration in women with polycystic ovary syndrome].
OBJECTIVE
The aim of the present study was to estimate the leptin role in the pathogenesis of polycystic ovary syndrome.


METHODS
The study was carried out in 21 obese women with PCO, 18 obese women without menstrual disturbances and 9 normal-weight healthy women.


METHODS
In all patients antropomethric parameters: weight, height, % of body fat, waist and hip girths were measured and than BMI and WHR were calculated. Plasma concentrations of leptin, insulin, LH, FSH, testosterone, cortisol, PRL, estradiol were estimated.


RESULTS
There were no statistical significant difference between plasma leptin concentrations in obese patients with PCO in comparison to obese women with normal menstrual cycle. In both groups of obese patients plasma leptin concentrations was significantly higher than in control group (p < 0.001, p < 0.001). There were significant correlation between plasma leptin and % body fat, BMI and waist girth in all studied groups.


CONCLUSIONS
We conclude that leptin is not directly involved in observed hormonal disturbances in polycystic ovary syndrome. The main predictor of plasma leptin concentrations in patients with PCO is amount of body fat.
Kowalska
I
I
Kliniki Endokrynologii Akademii Medycznej w Białymstoku.
Kinalski
M
M
Wołczyński
S
S
Straczkowski
M
M
Kinalska
I
I
Szamatowicz
M
M
D000328:Adult; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications
D020738:Leptin