title: Preparation and antimicrobial activity of micacocidin.
abstract: Micacocidin (3), a Zn-free derivative of micacocidin A (1), was prepared to evaluate its antimicrobial activity in comparison with 1 and to obtain a starting material for chemical modification of 1. The structure of 3, quite unlike those of any previously known antimicrobial agents, was elucidated by 1-D and 2-D homonuclear and heteronuclear NMR and mass spectroscopy. Micacocidin (3) thus prepared exhibited weak or no antibacterial activity except against Mycoplasma species, i.e. 3 showed stronger activity than 1. It is noteworthy that 3 displayed high activity against fungi such as Candida, Aspergillus and Trichophyton species.
authors.affiliation: Aburahi Laboratories, Shionogi & Co Ltd, Koka, Shiga, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ikenishi
authors.forename: Y
authors.initials: Y
authors.lastname: Takinami
authors.forename: M
authors.initials: M
authors.lastname: Takema
authors.forename: W Y
authors.initials: WY
authors.lastname: Sun
authors.forename: A
authors.initials: A
authors.lastname: Ino
authors.forename: Y
authors.initials: Y
authors.lastname: Hayase
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000145:classification / Q000187:drug effects*; D005658:Fungi / Q000145:classification / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; C112186:micacocidin A