Adhesion signaling: PAK meets Rac on solid ground.
Interaction of cells with the extracellular matrix influences various aspects of cellular behavior. A recent study shows that cell-substrate adhesion is necessary for effective coupling of the small GTPase Rac to its effector PAK.
Symons
M
M
The Picower Institute for Medical Research, Manhasset, NY 11030, USA. msymons@picower.edu.
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D015398:Signal Transduction; D054462:p21-Activated Kinases; D020744:rac GTP-Binding Proteins / Q000502:physiology*
D017346:Protein Serine-Threonine Kinases; D054462:p21-Activated Kinases; D020744:rac GTP-Binding Proteins