title: Kinetic studies on Ce(IV)-induced hydrolysis of single-stranded and double-stranded oligonucleotides.
abstract: The Ce(IV)-induced hydrolyses of DNA are kinetically investigated. The formation constants of the Ce(IV)-DNA complexes are in the following order: the single-stranded DNA > the double-stranded DNA >> the dinucleotide. On the other hand, the catalytic rate constants for the single-stranded DNA and the double-stranded DNA are comparable with each other, but both of them are much smaller than the value for the dinucleotide hydrolysis.
authors.affiliation: Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Igawa
authors.forename: J
authors.initials: J
authors.lastname: Sumaoka
authors.forename: M
authors.initials: M
authors.lastname: Komiyama
mesh_terms: D002563:Cerium / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000737:chemistry / Q000378:metabolism*; D015226:Dinucleoside Phosphates / Q000737:chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D006868:Hydrolysis; D007700:Kinetics
chemical_list: D004277:DNA, Single-Stranded; D015226:Dinucleoside Phosphates; D002563:Cerium; D004247:DNA