title: Hypertriglyceridemic waist: A marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men?
abstract: BACKGROUND
  The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles).
  
  
  RESULTS
  Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values >/=90 cm and with elevated TG levels (>/=2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P<0.03) compared with men with low waist and TG levels.
  
  
  CONCLUSIONS
  It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD.
authors.affiliation: Quebec Heart Institute, Laval Hospital Research Center, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Lemieux
authors.forename: A
authors.initials: A
authors.lastname: Pascot
authors.forename: C
authors.initials: C
authors.lastname: Couillard
authors.forename: B
authors.initials: B
authors.lastname: Lamarche
authors.forename: A
authors.initials: A
authors.lastname: Tchernof
authors.forename: N
authors.initials: N
authors.lastname: Alméras
authors.forename: J
authors.initials: J
authors.lastname: Bergeron
authors.forename: D
authors.initials: D
authors.lastname: Gaudet
authors.forename: G
authors.initials: G
authors.lastname: Tremblay
authors.forename: D
authors.initials: D
authors.lastname: Prud'homme
authors.forename: A
authors.initials: A
authors.lastname: Nadeau
authors.forename: J P
authors.initials: JP
authors.lastname: Després
mesh_terms: D000005:Abdomen; D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D015415:Biomarkers; D001823:Body Composition; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000473:pathology; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D015228:Hypertriglyceridemia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D008077:Lipoproteins, LDL; D014280:Triglycerides