title: Biomedical application of immobilized enzymes.
abstract: Reports on chemical immobilization of proteins and enzymes first appeared in the 1960s. Since then, immobilized proteins and enzymes have been widely used in the processing of variety of products and increasingly used in the field of medicine. Here, we present a review of recent developments in immobilized enzyme use in medicine. Generally speaking, the use of immobilized enzyme in medicine can be divided into two major categories: biosensors and bioreactors. A brief overview of the evolution of the biosensor and bioreactor technology, of currently existing applications of immobilized enzymes, of problems that researchers encountered, and of possible future developments will be presented.
authors.affiliation: College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109-1065, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Liang
authors.forename: Y T
authors.initials: YT
authors.lastname: Li
authors.forename: V C
authors.initials: VC
authors.lastname: Yang
mesh_terms: D000818:Animals; D019149:Bioreactors; D015374:Biosensing Techniques; D004337:Drug Carriers; D004800:Enzymes, Immobilized; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D008081:Liposomes; D012680:Sensitivity and Specificity
chemical_list: D004337:Drug Carriers; D004800:Enzymes, Immobilized; D008081:Liposomes