title: [A case of HTLV-I associated myelopathy with abnormal patchy MRI lesions in the spinal cord].
abstract: We report a case of HTLV-I associated myelopathy (HAM) with a spinal cord MRI showing abnormal multifocal and patchy lesions. A 50-year-old woman suffering from progressive paraparesis was admitted to our hospital. HTLV-I antibodies in the serum and CSF were positive, and a diagnosis of HAM was made. Her T2 weighted spinal cord MRI showed scattered areas of high signal intensity from the cervical to the thoracic cord. The lesions were enhanced with gadolinium-DTPA on T1 weighted imaging. Atrophy of the thoracic cord has been reported in many patients with HAM. In rare cases, T2 weighed thoracic cord MRI showed diffuse high signal intensity. The pattern of high signal intensity in our case, however, was multifocal and patchy, thus differing from the findings of previous reports. And we believe this is the first such report. This case suggests that the MRI of HAM patient may show multifocal and scattered lesions in the spinal cord.
authors.affiliation: Department of Neurology, Nishi-Kobe Medical Center, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Yanagihara
authors.forename: K
authors.initials: K
authors.lastname: Nakaji
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002574:Cervical Vertebrae; D005260:Female; D005682:Gadolinium; D015481:HTLV-I Antibodies / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000175:diagnosis* / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology*; D013904:Thoracic Vertebrae
chemical_list: D015415:Biomarkers; D015481:HTLV-I Antibodies; D005682:Gadolinium