title: Timing mechanisms in the cerebellum: testing predictions of a large-scale computer simulation.
abstract: We used large-scale computer simulations of eyelid conditioning to investigate how the cerebellum generates and makes use of temporal information. In the simulations the adaptive timing displayed by conditioned responses is mediated by two factors: (1) different sets of granule cells are active at different times during the conditioned stimulus (CS), and (2) responding is not only amplified at reinforced times but also suppressed at unreinforced times during the CS. These factors predict an unusual pattern of responding after partial removal of the cerebellar cortex that was confirmed using small, electrolytic lesions of cerebellar cortex. These results are consistent with timing mechanisms in the cerebellum that are similar to Pavlov's "inhibition of delay" hypothesis.
authors.affiliation: W. M. Keck Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Medina
authors.forename: K S
authors.initials: KS
authors.lastname: Garcia
authors.forename: W L
authors.initials: WL
authors.lastname: Nores
authors.forename: N M
authors.initials: NM
authors.lastname: Taylor
authors.forename: M D
authors.initials: MD
authors.lastname: Mauk
mesh_terms: D000818:Animals; D002529:Cerebellar Nuclei / Q000502:physiology; D002531:Cerebellum / Q000166:cytology / Q000502:physiology*; D003198:Computer Simulation; D003215:Conditioning, Eyelid / Q000502:physiology; D008297:Male; D008959:Models, Neurological; D009412:Nerve Fibers / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D011237:Predictive Value of Tests; D011690:Purkinje Fibers / Q000502:physiology; D011817:Rabbits; D011930:Reaction Time / Q000502:physiology*; D013569:Synapses / Q000502:physiology