Presence of human herpesvirus-8 DNA sequences and overexpression of human IL-6 and cyclin D1 in inflammatory myofibroblastic tumor (inflammatory pseudotumor).
Inflammatory myofibroblastic tumor (IMT) is composed of myofibroblasts, plasma cells, and lymphocytes. Cytokines are possibly involved in its pathogenesis. Human herpesvirus-8 (HHV-8) encodes cell cycle regulatory and signaling proteins. A combination of nested PCR with several negative controls and Southern blot methods showed the presence of HHV-8 DNA in seven cases of IMT. Additionally, strong expression was demonstrated by in situ hybridization in many tumoral nuclei. Most of the myofibroblasts in all of the cases were immunoreactive for human IL-6 and cyclin D1. These cytokines probably have a paracrine action and may sustain myofibroblastic growth. HHV-8 could play an essential role in triggering IMT development by a local reactivation of viral lytic replication. The relationship between HHV-8 and immunosuppression status as the only associated cause for tumorigenesis should be revised.
Gómez-Román
J J
JJ
Departamento de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Instituto Nacional de la Salud, Facultad de Medicina, Universidad de Cantabria, Santander, Spain.
Ocejo-Vinyals
G
G
Sánchez-Velasco
P
P
Nieto
E H
EH
Leyva-Cobián
F
F
Val-Bernal
J F
JF
D000328:Adult; D000368:Aged; D019938:Cyclin D1 / Q000378:metabolism*; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006104:Granuloma, Plasma Cell / Q000378:metabolism*; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D007866:Leg; D008175:Lung Neoplasms / Q000378:metabolism; D008198:Lymph Nodes; D008206:Lymphatic Diseases / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000378:metabolism
D004279:DNA, Viral; D015850:Interleukin-6; D019938:Cyclin D1