title: Neuropsychological functioning in nonreferred siblings of children with attention deficit/hyperactivity disorder.
abstract: The goal of this study was to assess neuropsychological functioning in nonreferred siblings of children with attention deficit/hyperactivity disorder (ADHD). Participants were 156 siblings of ADHD probands with (N = 40) and without (N = 116) ADHD (according to criteria of the Diagnostic and Statistical Manual of Mental Disorders (3rd edition, revised; American Psychiatric Association, 1987) and 118 siblings of non-ADHD normal controls of similar age, IQ, and grade level. Information on attention, executive, and memory functions was obtained in a standardized manner without knowledge of clinical status. Compared with siblings of controls, siblings with ADHD were significantly impaired on the Stroop test and on verbal learning and memory. In contrast, siblings without ADHD were similar to controls on virtually all measures. These data suggest that some executive, attention, and verbal learning deficits are found in nonreferred individuals with ADHD but that neuropsychological deficits are unlikely to constitute an endophenotype to ADHD.
authors.affiliation: Harvard Medical School.
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Seidman
authors.forename: Joseph
authors.initials: J
authors.lastname: Biederman
authors.forename: Michael C
authors.initials: MC
authors.lastname: Monuteaux
authors.forename: Wendy
authors.initials: W
authors.lastname: Weber
authors.forename: Stephen V
authors.identifier: 0000-0002-9217-3982
authors.initials: SV
authors.lastname: Faraone
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000523:psychology*; D016022:Case-Control Studies; D002648:Child; D003071:Cognition; D020022:Genetic Predisposition to Disease / Q000235:genetics / Q000523:psychology*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009679:Nuclear Family / Q000523:psychology*; D010641:Phenotype; D014706:Verbal Learning