title: Asymmetric Mannich-Type Reactions of Aldimines with a Chiral Acetate.
abstract: We introduce here a strategy that enables effective addition of lithium enolates of acetates to aldimines. The new method depends strongly on the use of o-alkoxy (or o-fluoro) aniline-derived aldimines which have been found to have a potential effect on the enolate addition. This scope was expanded to the asymmetric process using the chiral acetate. A Lewis acid additive has a complementary role in the pronounced activation of imine functionalities.
authors.affiliation: Graduate School of Engineering, Nagoya University, CREST, Japan Science and Technology Corporation (JST), Furo-cho, Chikusa, Nagoya 464-8603, Japan.
authors.initials: S
authors.lastname: Saito
authors.initials: K
authors.lastname: Hatanaka
authors.initials: H
authors.lastname: Yamamoto