Synthesis of beta-hydroxy ketones and vinylsilanes from homopropargylic alcohols by intramolecular hydrosilation
Catalytic intramolecular hydrosilation of nonracemic homopropargylic alcohols affords the corresponding five-membered cyclic siloxanes regiospecifically. Oxidation or alkylmetal addition converts these intermediates into beta-hydroxy ketones or vinylsilanes under mild conditions.
Marshall
JA
Department of Chemistry, McCormick Road, P.O. Box 400319, University of Virginia, Charlottesville, Virginia, 22904, USA.
Yanik
MM