title: Recurrent blastomycosis of the central nervous system: case report and review.
abstract: Although blastomycosis of the central nervous system (CNS) occurs in approximately 4% of patients with blastomycosis, recurrent CNS blastomycosis is very rare. We review the clinical features, treatment, and outcome of 4 previously reported cases. We also report a case of recurrent CNS blastomycosis successfully treated with surgery and liposomal amphotericin B after an inadequate response to amphotericin B therapy. This treatment may be an alternate approach for management of similar cases.
authors.affiliation: University of North Dakota School of Medicine, Fargo, ND 58122, USA. achowfin@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Chowfin
authors.forename: R
authors.initials: R
authors.lastname: Tight
authors.forename: S
authors.initials: S
authors.lastname: Mitchell
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001759:Blastomycosis / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D001921:Brain / Q000000981:diagnostic imaging; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D008081:Liposomes; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B