Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair.
This review, which is the final installment in a series devoted to controversial issues in acute renal failure (ARF) (3, 47), will examine available information regarding the role of growth factors in ARF. In general, studies in this area have fallen into two broad categories: 1) those that have examined the renal expression of genes encoding growth factors or transcriptional factors associated with the growth response that is induced after ARF, and 2) those that have examined the efficacy of exogenously administered growth factors in accelerating recovery of renal function in experimental models of ARF. Despite the vast amount of information that has accumulated in these two areas of investigation, our understanding of the mechanisms involved in the process of regeneration and repair after ARF, and the role of growth factors in this response, remains rudimentary. This overview, contributed to by a number of experts in the field, is designed to summarize present knowledge and to highlight potentially fertile areas for future research in this area.
Nigam
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Departments of Pediatrics and Medicine, University of California San Diego, La Jolla, California 92093-0693, USA.
Lieberthal
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D058186:Acute Kidney Injury / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012038:Regeneration / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects; D013312:Stress, Physiological / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D006133:Growth Substances