Alpha-amylase inhibitors from roselle (Hibiscus sabdariffa Linn.) tea.
A roselle (Hibiscus sabdariffa Linn.) tea extract was found to have high inhibitory activity against porcine pancreatic alpha-amylase. Hibiscus acid and its 6-methyl ester were respectively isolated as active principles from the 50% methanol and acetone extracts of roselle tea. The activity of each isolate was compared to that of structurally related citric acid, a previously known inhibitor of fungal alpha-amylase.
Hansawasdi
C
C
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Kawabata
J
J
Kasai
T
T
D000818:Animals; D001628:Beverages / Q000032:analysis*; D002951:Citrates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019343:Citric Acid / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D019685:Rosales; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D002951:Citrates; D004791:Enzyme Inhibitors; D019343:Citric Acid; C007999:hydroxycitric acid; D000516:alpha-Amylases