[An experimental study of the role of prostaglandins in the mechanism of the occurrence of dyspeptic disorders during the primary reaction after body exposure to ionizing radiation at large doses].
The experiments with dogs exposed to 100 Gy of accelerated electrons demonstrated a significant role of prostaglandins in the origin of early post-radiation dyspepsia. Their significance for genesis of post-radiation dyspeptic disturbance caused by exposure to superhigh doses becomes clear-cut when a combination of an antiemetic and inhibitors of prostaglandin biosynthesis is used. A study of the effect of dexamethasone, a blocker of arachidonic acid release, and of voltaren, an inhibitor of prostaglandin formation from cyclic endoperoxide, suggests that it would be appropriate to prevent radiation vomiting and diarrhea by inhibiting both of the above stages in prostaglandin biosynthesis.
Martirosov
K S
KS
State Research Center of Russia, Institute of Biophysics, Moscow. ibkoguc@alara.msk.su
Grigor'ev
Iu G
IuG
Zorin
V V
VV
Iashkin
P N
PN
D000208:Acute Disease; D000818:Animals; D000932:Antiemetics / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004008:Diclofenac / Q000627:therapeutic use; D004195:Disease Models, Animal; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000188:drug therapy / Q000209:etiology*; D004583:Electrons; D005260:Female; D008297:Male; D010315:Particle Accelerators; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D011453:Prostaglandins / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000150:complications* / Q000188:drug therapy; D011897:Random Allocation; D013997:Time Factors
D000932:Antiemetics; D001549:Benzamides; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D004008:Diclofenac; D003907:Dexamethasone; C037141:dimetpramid