title: Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development.
abstract: Paraxial protocadherin (PAPC) is a cell adhesion molecule that marks cells undergoing convergence-extension cell movements in Xenopus and zebrafish gastrulating embryos. Here a mouse homologue (mpapc) was identified and characterized. During early- to mid-gastrulation, mpapc is expressed in the primitive streak as the trunk mesoderm undergoes morphogenetic cell movements. At head-fold stage mpapc expression becomes localized to paraxial regions in which somites are formed in the segmental plate. At later stages, mpapc displays a complex expression pattern in cerebral cortex, olfactory bulb, inferior colliculus, and in longitudinal stripes in hindbrain. To analyze the effect of the loss of PAPC function during mouse development, a null allele of the mouse papc gene was generated. Homozygous animals show no defects in their skeleton and are viable and fertile.
authors.affiliation: Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. akihito@medic.kumamoto-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Yamamoto
authors.forename: C
authors.initials: C
authors.lastname: Kemp
authors.forename: D
authors.initials: D
authors.lastname: Bachiller
authors.forename: D
authors.initials: D
authors.lastname: Geissert
authors.forename: E M
authors.initials: EM
authors.lastname: De Robertis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015820:Cadherins / Q000096:biosynthesis* / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data
chemical_list: D015820:Cadherins