The pharmacokinetics and metabolism of sucralose in the mouse.
The excretion and metabolism of (14)C-sucralose has been investigated in mice following intravenous and oral administration. A 20mg/kg intravenous dose was rapidly excreted mainly in the urine (80% in 5 days). After 100, 1500 and 3000mg/kg oral doses of (14)C-sucralose, means of 23%, 15% and 16% of the dose, respectively, were excreted in the urine during 5 days. Comparison with the intravenous dose indicated that 20-30% of the oral doses was absorbed. Sucralose was excreted almost entirely unchanged and represented more than 80-90% of the radioactivity in all urine and faeces samples. Only two minor metabolites were detected, representing 2-8% of urine radioactivity.
John
B A
BA
Huntingdon Research Centre Ltd, Huntingdon, Cambs PE18 6ES, UK.
Wood
S G
SG
Hawkins
D R
DR
D000042:Absorption / Q000502:physiology; D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes / Q000652:urine; D002855:Chromatography, Thin Layer; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D011897:Random Allocation; D012588:Scintillation Counting; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D013549:Sweetening Agents / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*
D002250:Carbon Radioisotopes; D013549:Sweetening Agents; D013395:Sucrose; C026285:trichlorosucrose