title: Muscle CT scan findings in McLeod syndrome and chorea-acanthocytosis.
abstract: Computed tomography (CT) scans of lower leg muscles reveal a selective pattern of fat infiltration in the posterior compartment with spared gracilis, semitendinosus, and the lateral head of the gastrocnemius in both McLeod syndrome and chorea-acanthocytosis, which are disorders characterized by the presence of circulating acanthocytes. The selectivity of affected muscles indicates that late onset and slowly progressive muscular atrophy in both diseases could be a consequence of primary myopathy. Asymmetrical muscle involvement may be seen during the process of degeneration only in McLeod syndrome, however, and may be helpful in distinguishing this disease from chorea-acanthocytosis.
authors.affiliation: Department of Neurology, Nagano Red Cross Hospital, Nagano, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ishikawa
authors.forename: N
authors.initials: N
authors.lastname: Tachibana
authors.forename: K I
authors.initials: KI
authors.lastname: Tabata
authors.forename: N
authors.initials: N
authors.lastname: Fujimori
authors.forename: R I
authors.initials: RI
authors.lastname: Hayashi
authors.forename: J
authors.initials: J
authors.lastname: Takahashi
authors.forename: S I
authors.initials: SI
authors.lastname: Ikeda
authors.forename: N
authors.initials: N
authors.lastname: Hanyu
mesh_terms: D000328:Adult; D002819:Chorea / Q000097:blood / Q000000981:diagnostic imaging* / Q000235:genetics; D003402:Creatine Kinase / Q000097:blood; D005091:Exons / Q000235:genetics; D006801:Humans; D007626:Kell Blood-Group System; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000201:enzymology; D014057:Tomography, X-Ray Computed
chemical_list: D007626:Kell Blood-Group System; D003402:Creatine Kinase