title: Central 5-HT(4) receptors and drinking behavior.
abstract: The aim of the present study was to investigate the effect of acute third ventricle injections of two different 5-HT(4) receptor antagonists, GR 113808 and SB 204070, on water intake in different situations. Injections of 80 nmol/rat of both GR 113808 and SB 204070 were unable to modify water intake in normohydrated rats. Pretreatment with GR 113808 (40 and 80 nmol/rat) and SB 204070 (80 and 160 nmol/rat) blunted water intake after third ventricle injections of angiotensin II (9.6 pmol/rat) compared to saline-pretreated controls. Pretreatment with 80 nmol/rat of both antagonists potentiated drinking induced by third ventricle injections of carbachol (11.0 nmol/rat) compared to saline-pretreated control. In all doses employed, none of the compounds was able to modify water intake in dehydrated rats. A separate control test using one-bottle taste aversion paradigm indicated that the reduction in water intake observed in some of the present experiments could not be attributed to a drug-induced malaise. It is suggested that central 5-HT(4) receptors exert a dualistic role on the control of water intake potentiating angiotensin II-induced drinking and inhibiting thirst induced by central cholinergic activation
authors.affiliation: Department of Physiology, Health Sciences Institute, Federal University of Bahia, 40110-100 Salvador, Bahia, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Castro
authors.forename: E
authors.initials: E
authors.lastname: De Castro-E-Silva
authors.forename: A K
authors.initials: AK
authors.lastname: Lima
authors.forename: F S
authors.initials: FS
authors.lastname: Souza
authors.forename: I
authors.initials: I
authors.lastname: Maldonado
authors.forename: D F
authors.initials: DF
authors.lastname: Macêdo
authors.forename: M G
authors.initials: MG
authors.lastname: Ferreira
authors.forename: G F
authors.initials: GF
authors.lastname: Santamaria
authors.forename: I P
authors.initials: IP
authors.lastname: Bandeira
authors.forename: A L
authors.initials: AL
authors.lastname: Amor
authors.forename: F L
authors.initials: FL
authors.lastname: Carvalho
authors.forename: M A
authors.initials: MA
authors.lastname: Rocha
authors.forename: I R
authors.initials: IR
authors.lastname: Oliveira
authors.forename: J B
authors.initials: JB
authors.lastname: Fregoneze
mesh_terms: D000818:Animals; D004146:Dioxanes / Q000008:administration & dosage; D004326:Drinking / Q000187:drug effects / Q000502:physiology; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D007211:Indoles / Q000008:administration & dosage; D007276:Injections, Intraventricular; D008297:Male; D010880:Piperidines / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000502:physiology*; D044422:Receptors, Serotonin, 5-HT4; D012702:Serotonin Antagonists / Q000008:administration & dosage; D013449:Sulfonamides / Q000008:administration & dosage; D013894:Thirst / Q000187:drug effects / Q000502:physiology; D014868:Water Deprivation / Q000502:physiology
chemical_list: D004146:Dioxanes; D007211:Indoles; D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D013449:Sulfonamides; C084858:SB 204070A; D044422:Receptors, Serotonin, 5-HT4; C082871:GR 113808