title: Renal structural properties in prehypertensive Dahl salt-sensitive rats.
abstract: In 10- to 12-week-old Dahl salt-sensitive (DS) and salt-resistant (DR) rats fed a 0.3% salt diet (n=10 in each group), flow-pressure and pressure-glomerular filtration rate (F-P and P-GFR, respectively) relationships were established for maximally vasodilated perfused kidneys. From these relationships, 3 indices of vascular structural properties were estimated: slope of F-P (minimal renal vascular resistance reflecting overall luminal dimensions of preglomerular and postglomerular vasculature), slope of P-GFR (glomerular filtration capability against pressure), and threshold pressure for beginning filtration at P-GFR (preglomerular-to-postglomerular vascular resistance ratio). Thereafter, maximal renal vascular resistance was determined to assess wall-to-lumen ratios of the resistance vessels in half of each group. In the remainder, the kidneys were perfusion-fixed for histological analysis. Mean arterial pressure did not differ between the DS and DR rats. There were no significant differences in the slopes of F-P between the 2 groups. In contrast, the slope of P-GFR was significantly lower (33%) in DS rats than in DR rats, although the DS kidneys began filtering at a threshold pressure similar to that of the DR kidneys. Thus, in DS rats, there were no abnormalities in luminal dimensions at preglomerular and postglomerular vascular segments, but the kidney filtration capacity decreased at any given increase in pressure. Maximal vascular resistance was greater in DS than in DR rats, a finding compatible with the histological appearance, which showed vascular hypertrophy with little, if any, vascular narrowing in the interlobular arteries of DS rats. In conclusion, hypertrophic remodeling without vascular narrowing at preglomerular resistance vessels and structural defects in filtering at the glomeruli could occur in prehypertensive DS rats.
authors.affiliation: Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Tomoda
authors.forename: M
authors.initials: M
authors.lastname: Takata
authors.forename: H
authors.initials: H
authors.lastname: Kinuno
authors.forename: S
authors.initials: S
authors.lastname: Tomita
authors.forename: K
authors.initials: K
authors.lastname: Yasumoto
authors.forename: H
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000818:Animals; D006439:Hemodynamics; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D008297:Male; D051381:Rats; D012077:Renal Artery / Q000473:pathology / Q000503:physiopathology; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*
chemical_list: D017673:Sodium Chloride, Dietary