Mastocytosis and the skin.
The most frequent site of organ involvement in individuals with any form of mastocytosis is the skin. Cutaneous lesions include urticaria pigmentosa, mastocytoma, diffuse and erythematous cutaneous mastocytosis, and telangiectasia macularis eruptiva perstans. The major histologic feature is an increase in the number of mast cells in the dermis. Treatment depends on the type of skin lesions.
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Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, USA.
D000328:Adult; D017668:Age of Onset; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016207:Cytokines / Q000502:physiology; D015777:Eicosanoids / Q000502:physiology; D005483:Flushing / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008407:Mast Cells / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000473:pathology; D008415:Mastocytosis / Q000145:classification / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009928:Organ Specificity; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000502:physiology; D012878:Skin Neoplasms / Q000473:pathology; D019089:Stem Cell Factor / Q000235:genetics / Q000502:physiology; D013684:Telangiectasis / Q000209:etiology; D014582:Urticaria Pigmentosa / Q000235:genetics / Q000473:pathology
D016207:Cytokines; D015777:Eicosanoids; D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit