title: Enhancement of sodium intestinal secretion in relation to absorption in malnourished rats. Hyperosmolar challenge.
abstract: Two experimental models were tried in young malnourished rats in order to study effect of an hyperosmolar challenge in the small intestine on the bi-directional fluxes of sodium. Weanling rats were fed with energy restricted diets. In model I 1 mL of NaCl 900 mOsm/kg was introduced in the small intestine of the rats and left from 5 up to 70 min, in order to determine the moment of higher net Na+ secretion, which occurred at 10 min. In model II, the bi-directional fluxes of Na+ and Cl- were studied using NaCl or mannitol 900 mOsm/kg under the effect of mecholil, atropine or 2-4 dinitrophenol, for 10 min. Mecholil decreased the Na+ absorption enhancing the net secretion. Control rats were used as reference. In the restricted diets animals occurred an increase of the net secretion stimulated by NaCl 900 mOsm/kg, and this effect was enhanced by mecholil. It is suggested that in malnutrition there is an impairment in Na- intestinal absorption.
authors.affiliation: Universidade de São Paulo.
authors.forename: R C
authors.initials: RC
authors.lastname: de Angelis
authors.forename: J V
authors.initials: JV
authors.lastname: Campos
authors.forename: R N
authors.initials: RN
authors.lastname: Rogano
authors.forename: G G
authors.initials: GG
authors.lastname: Giuli
authors.forename: I C
authors.initials: IC
authors.lastname: Terra
authors.forename: J H
authors.initials: JH
authors.lastname: Scialfa
authors.forename: I
authors.initials: I
authors.lastname: Klemps Filho
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006982:Hypertonic Solutions / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage / Q000493:pharmacokinetics; D009748:Nutrition Disorders / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000493:pharmacokinetics; D012964:Sodium / Q000378:metabolism*
chemical_list: D006982:Hypertonic Solutions; D012462:Saline Solution, Hypertonic; D008353:Mannitol; D012964:Sodium