Intercellular adhesion molecule-1 (ICAM-1) K469E polymorphism: no association with type 1 diabetes among Finns.
The intercellular adhesion molecule-1 (ICAM-1) has an important role in the process of lymphocyte migration and activation, and is supposed to be involved in the pathogenesis of type 1 diabetes. We studied A/G (K469E) polymorphism of the ICAM-1 gene in 218 type 1 diabetes patients and 212 controls from Finland and found no association. We then studied transmission of the ICAM-1 alleles in 102 Finnish families using a transmission disequilibrium test (TDT). Alleles A and G were transmitted to the affected offspring in 50% each. Stratification by the HLA-DQB1-DQA1 genotypes, sex and age at onset did not reveal association. Our data demonstrate that in the Finnish population K469E polymorphism of the ICAM-1 gene is not associated with type 1 diabetes.
Nejentsev
S
S
JDF Centre for Prevention of Type 1 Diabetes in Finland, Turku. serneje@utu.fi
Laine
A P
AP
Simell
O
O
Ilonen
J
J
D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D018698:Glutamic Acid / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008239:Lysine / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
D018799:Intercellular Adhesion Molecule-1; D018698:Glutamic Acid; D008239:Lysine