title: Poliovirus-specific intestinal antibody responses coincide with decline of poliovirus excretion.
abstract: Antibody responses to poliovirus type 3 were studied in fecal samples of 66 children immunized with 3 doses of enhanced-potency inactivated poliovirus vaccine (E-IPV), followed by 1 dose of monovalent oral poliovirus vaccine (OPV, type 3 Sabin). One fecal sample taken before OPV vaccination and 9 collected thereafter were tested for neutralizing antibodies by a microneutralization assay and for class-specific responses by heavy chain-capture radioimmunoassays. Both neutralizing antibody and IgA responses usually occurred during the second week and coincided with ceasing of virus excretion or a decrease in the excreted virus titer. Half of the vaccinees had received a trypsin-modified E-IPV, but their responses did not differ from those of children immunized with the regular E-IPV. These results are in agreement with the view that an intestinal antibody response, mainly consisting of IgA, may be involved in the ceasing of a primary poliovirus excretion.
authors.affiliation: Department of Biochemistry, National Public Health Institute, Helsinki, Finland. sanna.valtanen@ktl.fi
authors.forename: S
authors.initials: S
authors.lastname: Valtanen
authors.forename: M
authors.initials: M
authors.lastname: Roivainen
authors.forename: L
authors.initials: L
authors.lastname: Piirainen
authors.forename: M
authors.initials: M
authors.lastname: Stenvik
authors.forename: T
authors.initials: T
authors.lastname: Hovi
mesh_terms: D005243:Feces / Q000821:virology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D007422:Intestines / Q000276:immunology*; D017955:Poliovirus / Q000276:immunology*; D011054:Poliovirus Vaccine, Inactivated / Q000276:immunology*; D019562:Viral Load
chemical_list: D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011054:Poliovirus Vaccine, Inactivated; C033027:secretory IgM