Isoprostanes quickly normalize after quitting cigarette smoking in healthy adults.
BACKGROUND
Isoprostanes and in particular 8-epi-PGF2 alpha have been claimed as a useful measure for invivo oxidation injury. While smokers show elevated 8-epi-PGF2 alpha the behaviour during quitting smoking is unknown.


RESULTS
We determined 8-epi-PGF2 alpha in 7 healthy adults ready to quit smoking in plasma, serum and urine by means of an enzyme immunoassay after extraction and purification before quitting smoking and during a follow-up period of 4 weeks. After quitting smoking, 8-epi-PGF2 alpha shows a rapid decline within a few days almost completely normalizing within 4 weeks.


CONCLUSIONS
The cigarette-smoking associated invivo oxidation injury almost completely disappears within 4 weeks of quitting smoking.
Oguogho
A
A
Department of Nuclear Medicine, University of Vienna, Austria.
Lupattelli
G
G
Palumbo
B
B
Sinzinger
H
H
D000328:Adult; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D012907:Smoking / Q000097:blood; D016540:Smoking Cessation; D014662:Vasoconstrictor Agents / Q000097:blood*
D014662:Vasoconstrictor Agents; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost