Regiospecific carbonylative annulation of iodophenol acetates and acetylenes to construct the flavones by a new catalyst of palladium-thiourea-dppp complex.
[reaction: see text] Regiospecific carbonylative annulation of o-iodophenol acetates and acetylenes mediated by palladium-thiourea-dppp complex in the presence of base at 40 degrees C under a balloon pressure of CO generates diversified flavones in high yields. This newly developed synthetic technology provides a highly efficient method for potential application to the combinatorial synthesis of those heterocycles on the solid support.
Miao
H
H
Harvard Institute of Chemistry and Cell Biology, Harvard University, Boston, MA 02115-5731, USA.
Yang
Z
Z
D000114:Acetylene / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D005419:Flavonoids / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry
D005419:Flavonoids; D010636:Phenols; D010165:Palladium; D013890:Thiourea; D000114:Acetylene