title: Lateral parabrachial lesions impair intraperitoneal but not intraventricular methylscopolamine-induced taste aversion learning.
abstract: The role of the lateral parabrachial area (lPB) in the acquisition of a delayed taste aversion learning task (TAL) was examined by delivering the peripherally acting aversive compound, methylscopolamine (MSP), through two different routes, intraperitoneal and intraventricular. Consistent with previous anatomical, behavioral and molecular work, electrolytic lesions centered at the lPB did impair TAL when the MSP was injected intraperitoneally. However, lPB-lesioned animals exhibited intact learning capacities when MSP was administered intraventricularly. These results are interpreted in terms of the lPB as a critical anatomical relay involved in bottom-up visceral processing of aversive stimuli and also in relation to the relevance of forebrain structures in TAL.
authors.affiliation: Departamento de Psicología Experimental y Psicobiología, Universidad de Almería, 04120, Almería, Spain. icubero@filabres.ualm.es
authors.forename: I
authors.initials: I
authors.lastname: Cubero
authors.forename: A
authors.initials: A
authors.lastname: Puerto
mesh_terms: D000704:Analysis of Variance; D001362:Avoidance Learning / Q000187:drug effects*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D019832:N-Methylscopolamine / Q000008:administration & dosage / Q000494:pharmacology*; D011149:Pons / Q000187:drug effects / Q000502:physiology*; D016548:Prosencephalon / Q000502:physiology; D013649:Taste
chemical_list: D019832:N-Methylscopolamine