Measurements of human brain ethanol T(2) by spectroscopic imaging at 4 T.
Previous MRS measurements of ethanol in human brain have yielded a range of transverse relaxation times for ethanol methyl resonance at 1.5 T (200-380 ms). To determine the T(2) of the methyl proton resonance of ethanol in human brain, 8 x 8 spectroscopic images were acquired at 16 different TE values. A frequency-selective refocusing pulse was used to suppress J-modulation of the ethanol triplet, permitting nonintegral multiples of 1/J to be used for TE values. The measured T(2) values for the methyl resonances of ethanol, creatine, and N-acetyl aspartate in mixed tissues were 82 +/- 12, 148 +/- 20, and 227 +/- 25 ms, respectively. Regression analysis of the measured T(2) as a function of gray matter content indicates a shorter T(2) value for ethanol in pure white matter compared to that in pure gray matter. Magn Reson Med 44:35-40, 2000.
Sammi
M K
MK
Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA. msammi@bnl.gov
Pan
J W
JW
Telang
F W
FW
Schuhlein
D
D
Molina
P E
PE
Volkow
N D
ND
Springer
C S
CS
Hetherington
H P
HP
D000328:Adult; D001921:Brain / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
D000431:Ethanol