title: "Glaucoma affecting each crystalline lens": a long-lost manuscript by Dr. William Mackenzie.
abstract: Dr. William Mackenzie was one of the great pioneers of British ophthalmology in the 19th century. We present a newly-discovered manuscript in which Mackenzie described how he performed surgery for bilateral nuclear sclerosis of the lens, in 1842-1843. This case became the focus for a discussion of the nature of "cataract" and "glaucoma" in the fourth edition of Mackenzie's great work, A practical treatise on diseases of the eye. Mackenzie is generally remembered as a great compiler of knowledge, but the text Mackenzie built around this case shows him pursuing original arguments based on his own observation. This case report gives us a vignette of Mackenzie that illustrates aspects of Mackenzie's character and achievements in an intimate way, and it dramatizes in a lively manner how some of the most fundamental concepts in ophthalmology evolved.
authors.affiliation: Inverclyde Royal Hospital, Greenock, Scotland. gowa12@udcf.gla.ac.uk
authors.forename: D
authors.initials: D
authors.lastname: Mansfield
authors.forename: J
authors.initials: J
authors.lastname: Beaton
authors.forename: H
authors.initials: H
authors.lastname: Bennett
mesh_terms: D002386:Cataract / Q000209:etiology / Q000266:history*; D002387:Cataract Extraction / Q000266:history*; D005901:Glaucoma / Q000150:complications / Q000266:history*; D049671:History, 18th Century; D049672:History, 19th Century; D006801:Humans; D007908:Lens, Crystalline / Q000473:pathology*; D008373:Manuscripts as Topic / Q000266:history*; D009885:Ophthalmology / Q000266:history*; D006113:United Kingdom