Regional differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori isolates from Japan.
The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions in Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and 12.9%, respectively. While there was no difference in clarithromycin resistance, the prevalence of metronidazole resistance was significantly higher in Kyoto (23.8%) than in Sapporo (8.1%). From 1996 to 1999, the prevalence of metronidazole resistance did not change but the prevalence of clarithromycin resistance doubled (from 9.1 to 18.7%).
Kato
M
M
Department of Endoscopy, Hokkaido University School of Medicine, Sapporo, Japan.
Yamaoka
Y
Y
Kim
J J
JJ
Reddy
R
R
Asaka
M
M
Kashima
K
K
Osato
M S
MS
El-Zaatari
F A
FA
Graham
D Y
DY
Kwon
D H
DH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005260:Female; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008875:Middle Aged
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D017291:Clarithromycin