title: Screening relatives of patients with familial chronic open angle glaucoma.
abstract: OBJECTIVE
  To describe the value and the results of screening of family members of individuals with familial chronic open-angle glaucoma (COAG) for the disease.
  
  
  METHODS
  Cross-sectional study of families with COAG.
  
  
  METHODS
  Eighty-six individuals from 15 families with COAG.
  
  
  METHODS
  Complete ophthalmologic examinations, automated perimetry, and optic nerve photography.
  
  
  METHODS
  Disease status as glaucoma patient (at least two of three parameters abnormal: intraocular pressure, visual field, or disc appearance), glaucoma suspect (one of three parameters abnormal), or normal.
  
  
  RESULTS
  Twenty-six relatives were diagnosed with COAG. The diagnosis was most frequently made on the basis of intraocular pressure readings and automated perimetry. Twenty-three relatives were classified as glaucoma suspects; automated perimetry was the most useful modality for the detection of abnormalities in these individuals. Siblings of COAG patients had the highest risk of COAG developing (64.7%) compared with children (13.2%) or other blood relatives (22.2%).
  
  
  CONCLUSIONS
  When COAG is present in more than one family member, immediate and other relatives should be evaluated for glaucoma by means of clinical examination and automated perimetry.
authors.affiliation: The Johns Hopkins Bayview Medical Center and the Wilmer Eye Institute, The Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Nguyen
authors.forename: S C
authors.initials: SC
authors.lastname: Raja
authors.forename: E I
authors.initials: EI
authors.lastname: Traboulsi
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005190:Family; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D015351:Vision Screening / Q000379:methods*; D058609:Visual Field Tests; D014794:Visual Fields