Chiral monodentate phosphine ligand MOP for transition-metal-catalyzed asymmetric reactions.
Chiral monophosphines, whose chirality is due to biaryl axial chirality, have been prepared from enantiomerically pure 2, 2'-dihydroxy-1,1'-binaphthyl and demonstrated to be highly efficient chiral ligands for transition-metal-catalyzed organic transformations, especially for reactions where chelating bisphosphine ligands cannot be used. The high efficiency is observed in palladium-catalyzed asymmetric hydrosilylation of a wide variety of olefins such as alkyl-substituted terminal olefins and in asymmetric reactions via pi-allylpalladium intermediates represented by asymmetric reduction of allylic esters with formic acid.
Hayashi
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Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
D002384:Catalysis; D008024:Ligands; D019216:Metals, Heavy / Q000737:chemistry*; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry
D008024:Ligands; D019216:Metals, Heavy; D009281:Naphthalenes; D009942:Organometallic Compounds; D010720:Phosphines; D012821:Silanes; D010165:Palladium