title: Factors that influence adolescent adaptation to sickle cell disease.
abstract: OBJECTIVE
  To examine whether psychosocial factors play a more important role than biomedical risk factors in predicting adolescent adaptation to sickle cell disease (SCD); to determine whether psychosocial factors moderate the relationship between biomedical risk factors and adaptation.
  
  
  METHODS
  Ninety African American adolescents from the multisite Cooperative Study of Sickle Cell Disease were recruited to complete a battery that included measures of psychosocial status and psychological adaptation. Data regarding their health status were collected from medical records.
  
  
  RESULTS
  The findings revealed that intrapersonal (self-esteem, social assertiveness), stress-processing (use of social support), and social ecological factors (family relations) were significant predictors of adaptation; however, biomedical factors did not predict adaptation. There was no evidence that psychosocial factors moderated the relationship between biomedical risk factors and adaptation.
  
  
  CONCLUSIONS
  Psychosocial factors proved to be better predictors of adaptation than biomedical risk factors. Additional research is needed to better understand the nature of the interrelationships among biomedical risk factors, psychosocial factors, and adaptation.
authors.affiliation: Department of Psychology, University of Cincinnati, Ohio 45221, USA. kathleen.burlew@uc.edu
authors.forename: K
authors.initials: K
authors.lastname: Burlew
authors.forename: J
authors.initials: J
authors.lastname: Telfair
authors.forename: L
authors.initials: L
authors.lastname: Colangelo
authors.forename: E C
authors.initials: EC
authors.lastname: Wright
mesh_terms: D000223:Adaptation, Psychological; D000293:Adolescent; D001741:Black or African American / Q000523:psychology; D000755:Anemia, Sickle Cell / Q000523:psychology*; D001007:Anxiety / Q000523:psychology; D003863:Depression / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008962:Models, Theoretical; D011569:Psychiatric Status Rating Scales; D012494:Sampling Studies; D012720:Severity of Illness Index; D012917:Social Adjustment; D013315:Stress, Psychological / Q000209:etiology*; D014481:United States