title: Sleep deprivation stimulates serotonin release in the suprachiasmatic nucleus.
abstract: Recent literature suggests that sleep deprivation has a general stimulatory effect on the central serotonergic system. Herein we report that in hamsters, sleep deprivation induced by gentle handling for 3 h under dim red light at midday stimulates serotonin release in the suprachiasmatic nuclei by as much as 171%. Basal levels of 5-HT release are re-established within 1 h after cessation of treatment. Sleep deprivation also evokes phase advances of the circadian activity rhythm averaging 2 h. When sleep deprivation is undertaken in bright light, serotonin release is stimulated, but phase-shifting is greatly inhibited. It is therefore proposed that if the phase-resetting response to sleep deprivation is mediated by increased serotonin release, light inhibits the phase-resetting effect by blocking the postsynaptic or other downstream actions of serotonin.
authors.affiliation: Department of Biological Sciences, Kent State University, OH 44242-0001, USA.
authors.forename: G H
authors.initials: GH
authors.lastname: Grossman
authors.forename: R E
authors.initials: RE
authors.lastname: Mistlberger
authors.forename: M C
authors.initials: MC
authors.lastname: Antle
authors.forename: J C
authors.initials: JC
authors.lastname: Ehlen
authors.forename: J D
authors.initials: JD
authors.lastname: Glass
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D012701:Serotonin / Q000378:metabolism*; D012892:Sleep Deprivation / Q000378:metabolism*; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*
chemical_list: D012701:Serotonin