Fast echo planar based correlation-peak imaging: demonstration on the rat brain in vivo.
Two-dimensional correlation spectroscopy (2D-COSY) was combined with a fast echo planar based spectroscopic imaging technique in a new sequence. It can be optimized according to the coupling patterns of particular metabolites by using a constant time (CT) variant of COSY with chemical shift selective excitation and refocusing. Experiments were performed with an evolution time of 110 ms which was determined by simulating the CT-COSY experiment at several evolution times for the spin systems of myo-inositol (Ins) and taurine (Tau). The sequence has a minimum total measurement time of 17 min and was tested on a spherical phantom filled with a solution of Ins. The in vivo application of this method on the healthy rat brain demonstrates its improved spectral resolution as cross-peak signals from both Ins and Tau can be separated clearly. Magn Reson Med 44:23-28, 2000.
Mayer
D
D
Universität Bremen, Fachberelch 2 (Chemie), Bremen, Germany.
Dreher
W
W
Leibfritz
D
D
D000818:Animals; D001921:Brain / Q000378:metabolism*; D017352:Echo-Planar Imaging / Q000379:methods*; D007294:Inositol / Q000378:metabolism; D019047:Phantoms, Imaging; D051381:Rats; D013654:Taurine / Q000378:metabolism
D013654:Taurine; D007294:Inositol