[Insular system of animals in a chronic heparin deficiency].
The chronic heparin deficiency achieved by long-term treatment (for 3 weeks) with protamine-sulfate is accompanied by the development of stable hyperglycemia, decreased glucose tolerance, and the appearance of insulin resistance. Administration of exogenous heparin promotes the restoration of normoglycemia.
Ul'ianov
A M
AM
Laboratory of Protective Blood Systems, School of Biology, Moscow State University, Russia.
Tarasov
Iu A
IuA
D000818:Animals; D005951:Glucose Tolerance Test; D006493:Heparin / Q000008:administration & dosage / Q000172:deficiency* / Q000627:therapeutic use; D006494:Heparin Antagonists / Q000008:administration & dosage; D006943:Hyperglycemia / Q000188:drug therapy / Q000209:etiology*; D007333:Insulin Resistance; D008297:Male; D011479:Protamines / Q000008:administration & dosage; D051381:Rats
D006494:Heparin Antagonists; D011479:Protamines; D006493:Heparin