Mapping of the N terminus of the Schistosoma mansoni tegumental antigen Sm15 to its predicted precursor protein.
Sm15 is a major Schistosoma mansoni 15 kDa tegumental antigen, resulting from the proteolytic processing of a larger precursor. The amino terminus of Sm15 was identified by direct amino acid sequencing, and the antigen was tentatively mapped to the segment spanning amino acids 362-497 of the precursor. This will allow subsequent studies to elucidate the possible immunological role of proteolytic processing in schistosomiasis.
Werkhäuser
R P
RP
Departamento de Imunologia, Cidade Universitária, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Av. Moraes Rego s/n, 50670-420, PE, Recife, Brazil.
De Simone
S G
SG
Xavier
E
E
Montenegro
S M
SM
Abath
F G
FG
D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry*; D015153:Blotting, Western; D003001:Cloning, Molecular; D016054:DNA, Protozoan / Q000737:chemistry; D018604:Epitope Mapping; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000737:chemistry*; D012550:Schistosoma mansoni / Q000737:chemistry* / Q000276:immunology; D020539:Sequence Analysis, Protein
D000953:Antigens, Protozoan; D016054:DNA, Protozoan; D011498:Protein Precursors