title: Hepatic ceroid-lipofuscinosis in enzootic cardiomyopathy of sika deer (Cervus nippon temminck).
abstract: Hepatic lesions in 25 sika deer (Cervus nippon Temminck) aged 1-15 days, affected by selenium-deficiency cardiomyopathy, were examined histopathologically. Characteristic pathological findings, induced by stagnation of the plasma proteins of the cytoplasm, consisted of vacuolar degeneration of hepatocytes, formation of hyalin droplets, and ceroid-lipofuscinosis. Electron microscopically, these changes were closely associated with degeneration of the endoplasmic reticulum and mitochondria. Peroxisomes, which were observed around the vacuoles, were regarded as a reactive result of membrane disturbance caused by a decrease in glutathione peroxidase (GSH-Px)
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori 034, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshioka
authors.forename: M
authors.initials: M
authors.lastname: Domi
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Xia
authors.forename: T
authors.initials: T
authors.lastname: Oyamada
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D002566:Ceroid / Q000378:metabolism*; D003593:Cytoplasm / Q000473:pathology; D003670:Deer; D005260:Female; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008062:Lipofuscin / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D012643:Selenium / Q000097:blood / Q000172:deficiency; D014617:Vacuoles / Q000473:pathology
chemical_list: D002566:Ceroid; D008062:Lipofuscin; D012643:Selenium