title: Initiation of neural induction by FGF signalling before gastrulation.
abstract: During neural induction, the 'organizer' of the vertebrate embryo instructs neighbouring ectodermal cells to become nervous system rather than epidermis. This process is generally thought to occur around the mid-gastrula stage of embryogenesis. Here we report the isolation of ERNI, an early response gene to signals from the organizer (Hensen's node). Using ERNI as a marker, we present evidence that neural induction begins before gastrulation--much earlier in development than previously thought. We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction.
authors.affiliation: Department of Genetics and Development, Columbia University, New York, New York 10032, USA.
authors.forename: A
authors.initials: A
authors.lastname: Streit
authors.forename: A J
authors.initials: AJ
authors.lastname: Berliner
authors.forename: C
authors.initials: C
authors.lastname: Papanayotou
authors.forename: A
authors.initials: A
authors.lastname: Sirulnik
authors.forename: C D
authors.initials: CD
authors.lastname: Stern
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D019556:COS Cells; D002642:Chick Embryo; D046508:Culture Techniques; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000378:metabolism; D004627:Embryonic Induction; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000096:biosynthesis / Q000502:physiology*; D005775:Gastrula; D006609:High Mobility Group Proteins / Q000096:biosynthesis / Q000378:metabolism; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D009420:Nervous System / Q000196:embryology*; D020897:Organizers, Embryonic; D011784:Quail; D055748:SOXB1 Transcription Factors; D015398:Signal Transduction; D014157:Transcription Factors
chemical_list: D030161:Avian Proteins; D004268:DNA-Binding Proteins; C410845:ERNI protein, chicken; D006609:High Mobility Group Proteins; D009419:Nerve Tissue Proteins; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors