A comparison of the patterns of striatal Fos-like immunoreactivity induced by various dopamine agonists in rats.
In contrast to the highly patchy patterns of Fos-like immunoreactivity seen in the rostral striatum after administration of a number of dopamine agonists, the monoamine uptake blocker cocaine has been reported to produce a relatively homogeneous pattern of gene expression. In the current study we extended these observations by using a quantitative technique to demonstrate that while amphetamine and apomorphine produce patchy striatal Fos expression, the selective dopamine uptake inhibitors amfonelic acid, nomifensine and GBR-12909 all, like cocaine, produce near random patterns of gene expression. These findings suggest that the production of relatively 'non-patchy' patterns of immediate early gene expression may be a general property of dopamine transport inhibitors unrelated to any unique pharmacological properties of cocaine.
Wirtshafter
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Department of Psychology and Laboratory of Integrative Neuroscience, The University of Illinois at Chicago, 1007 W. Harrison Street, Chicago, IL 60607-7137, USA. davew@uic.edu
D000661:Amphetamine / Q000008:administration & dosage; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage; D003042:Cocaine / Q000008:administration & dosage; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism*; D018491:Dopamine Agonists / Q000008:administration & dosage*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D008297:Male; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000008:administration & dosage; D009627:Nomifensine / Q000008:administration & dosage; D010879:Piperazines / Q000008:administration & dosage; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013194:Staining and Labeling
D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; D009287:Naphthyridines; D010879:Piperazines; D016760:Proto-Oncogene Proteins c-fos; D009627:Nomifensine; D009268:Nalidixic Acid; C043425:vanoxerine; D000661:Amphetamine; D003042:Cocaine; D001058:Apomorphine; C006486:amfonelic acid