title: [Evaluation of an specific treatment for Trypanosoma cruzi in children, in the evolution of the indeterminate phase].
abstract: Twelve chagasic patients between the ages of seven and twelve, in the indeterminate phase with serology and xenodiagnosis positive, received the specific treatment. Eight of these were evaluated after an eight-year treatment period and four were followed-up during 20 years. Two patients took 7 mg/kg of nifurtimox during sixty and ninety days and ten of these used 5-7 mg/kg of benznidazole during 60 days. The clinical outcome was verified through clinical examination, electrocardiogram and contrasted X-ray of the esophagus. After the treatment, only one patient presented negativity in all the examinations. Seven (58.4%) remained in the indeterminate form and despite the precocious treatment four chagasic patients (33.3%) progressed clinically to second degree cardiopathy and/or megaesophagus.
authors.affiliation: Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasília, DF, Brasil.
authors.forename: C A
authors.initials: CA
authors.lastname: Silveira
authors.forename: E
authors.initials: E
authors.lastname: Castillo
authors.forename: C
authors.initials: C
authors.lastname: Castro
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009547:Nifurtimox / Q000627:therapeutic use*; D009593:Nitroimidazoles / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi
chemical_list: D009593:Nitroimidazoles; D014344:Trypanocidal Agents; D009547:Nifurtimox; C009999:benzonidazole