title: Nonimmune interaction of the SfbI protein of Streptococcus pyogenes with the immunoglobulin G F(ab')(2) fragment.
abstract: Fibronectin-binding protein I (SfbI) of Streptococcus pyogenes binds to mouse immunoglobulin G (IgG) but not to IgA or IgM in a nonimmune fashion. The fibronectin-binding domains of SfbI were responsible for this activity, which was targeted to the IgG F(ab')(2) fragment. SfbI also binds to B cells but not to CD4(+) or CD8(+) lymphocytes.
authors.affiliation: Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF-German Research Centre for Biotechnology, D-38124 Braunschweig, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Medina
authors.forename: K
authors.initials: K
authors.lastname: Schulze
authors.forename: G S
authors.initials: GS
authors.lastname: Chhatwal
authors.forename: C A
authors.initials: CA
authors.lastname: Guzmán
mesh_terms: D018829:Adhesins, Bacterial; D000276:Adjuvants, Immunologic / Q000378:metabolism; D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000378:metabolism*; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism*; D051379:Mice; D011485:Protein Binding; D013154:Spleen / Q000166:cytology / Q000378:metabolism; D013297:Streptococcus pyogenes
chemical_list: D018829:Adhesins, Bacterial; D000276:Adjuvants, Immunologic; D001426:Bacterial Proteins; D002352:Carrier Proteins; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; C078635:fibronectin-binding proteins, bacterial