title: Development of an eight-hour occupational exposure limit for beryllium.
abstract: This article recommends an 8-hour occupational exposure limit (OEL) for beryllium. It responds to growing concerns about the continuing incidence of chronic beryllium disease despite the long-standing OEL for beryllium: 2 micrograms of beryllium per cubic meter of air (microgram/m3), 8-hour time-weighted average (TWA). Current 8-hour TWA beryllium OELs are not based on chronic beryllium disease toxicology and an increasing number of studies report incidence of chronic beryllium disease at exposure levels apparently below 2 micrograms/m3. The experience of the beryllium-exposed population of Lorain, Ohio, in the late 1940s, and the ambient air regulatory standards derived from that event provide evidence that establishing a protective level is possible. These levels are used as the basis for a new recommended beryllium exposure standard. A correspondingly protective 8-hour TWA level of 0.1 microgram/m3 has been derived, which, for commonly encountered workplace conditions (in terms of geometric standard deviation and percent-compliance), should provide long-term mean exposure protection comparable to that received by the unaffected Lorain subpopulation and provided by the Environmental Protection Agency (EPA) ambient standard. It is concluded that an exposure limit of 0.1 microgram/m3 combined with exposure monitoring to assure a high rate of day-to-day compliance would provide better control of both long-term mean exposure levels and short-term levels than do current occupational exposure limits. The health data available, while certainly not conclusive, support further reductions in exposure levels to help minimize the incidence of chronic beryllium disease.
authors.affiliation: U.S. Department of Energy, Washington, D.C., USA.
authors.forename: P F
authors.initials: PF
authors.lastname: Wambach
authors.forename: R M
authors.initials: RM
authors.lastname: Tuggle
mesh_terms: D000395:Air Pollutants, Occupational / Q000592:standards; D001607:Berylliosis / Q000517:prevention & control*; D001608:Beryllium / Q000009:adverse effects / Q000032:analysis*; D006801:Humans; D016273:Occupational Exposure / Q000592:standards*; D016272:Occupational Health; D012016:Reference Values; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D000395:Air Pollutants, Occupational; D001608:Beryllium