Advantages and disadvantages of trial designs: a review of analysis methods for ICD studies. AVID Investigators.
General modalities of analyses that have been used for ICD studies are reviewed. Published "typical" examples are briefly described. The historical cohort method is exemplified with previously unpublished data from the Seattle Cardiac Arrest Survivor database. The AVID Study database is used to compare the results obtained from nonrandomized methodologies with randomized methodologies. Particular issues related to the use of the ICD for example, mode of death, inability to blind, selection practice, and treatment decision times make this a natural pedagogic platform.
Hallstrom
A P
AP
Department of Biostatistics, University of Washington, Seattle 98105, USA. aph@u.washington.edu
Anderson
J L
JL
Cobb
L A
LA
Friedman
P L
PL
Herre
J M
JM
Klein
R C
RC
McAnulty
J
J
Steinberg
J S
JS
D015982:Bias; D016022:Case-Control Studies; D002986:Clinical Trials as Topic / Q000379:methods*; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D019992:Databases as Topic; D017147:Defibrillators, Implantable; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D015996:Survival Rate; D016896:Treatment Outcome