Persistent mydriasis following intravenous atropine in a neonate.
A neonate whose mother had recently taken amitriptyline developed fixed dilated pupils after a modest dose of intravenous atropine. Interaction of atropine with neonatal amitriptyline levels is suggested and evidence of neonatal effects from maternal antidepressant use is examined. There were no neurological sequelae, and the neonate's pupils became reactive again after 7 h.
Yung
M
M
Department of Paediatric Anaesthesia, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Herrema
I
I
D000328:Adult; D000639:Amitriptyline / Q000009:adverse effects; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects; D001049:Apnea / Q000188:drug therapy; D001285:Atropine / Q000008:administration & dosage / Q000009:adverse effects*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D020139:Gastroschisis / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D008431:Maternal-Fetal Exchange; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D015878:Mydriasis / Q000139:chemically induced*; D010102:Oxygen Inhalation Therapy; D011247:Pregnancy
D000929:Antidepressive Agents, Tricyclic; D001993:Bronchodilator Agents; D018727:Muscarinic Antagonists; D000639:Amitriptyline; D001285:Atropine