Reinstatement of both a conditioned place preference and a conditioned place aversion with drug primes.
In two experiments, we report that the place-conditioning paradigm can be used to demonstrate reinstatement of place preference/aversion by a drug prime following extinction training. In Experiment 1, rats were trained to prefer a chamber paired with morphine. Following extinction training, a morphine drug prime reinstated the morphine place preference. In Experiment 2, a lithium-induced conditioned place aversion was reinstated following extinction training by a lithium prime prior to testing. These results indicate that not only do rewarding drug primes produce reinstatement of learned responses (as demonstrated in the drug self-administration paradigm), but also aversive drug primes reinstate aversive learned responses.
Parker
L A
LA
Departments of Psychology, Wilfrid Laurier University, Waterloo, Canada.
Mcdonald
R V
RV
D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects; D007858:Learning / Q000187:drug effects*; D018021:Lithium Chloride / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward
D000701:Analgesics, Opioid; D018692:Antimanic Agents; D009020:Morphine; D018021:Lithium Chloride