Cutaneous malakoplakia: a report of two cases with the use of anti-BCG for the detection for micro-organisms.
Malakoplakia is an uncommon granulomatous infectious disease that is found primarily in the genito-urinary tract, but may rarely involve the skin. Histologic findings are marked by the presence of foamy macrophages containing basophilic concentric spherules, the Michaelis-Gutman bodies. Micro-organisms are not readily identifiable. Immunostaining with polyclonal anti-mycobacterium bovis (BCG) has been described as a method of identifying bacterial and fungal organisms in situations where organisms may be sparse. We report 2 cases of cutaneous malakoplakia with demonstration of organisms by immunostaining with anti-BCG antibodies.
Mehregan
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Pinkus Dermatopathology Laboratory, Monroe, MI 48161, USA.
Mehregan
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Mehregan
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D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D001365:Axilla; D006119:Groin; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D008287:Malacoplakia / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009163:Mycobacterium bovis / Q000276:immunology; D012867:Skin / Q000473:pathology; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis* / Q000473:pathology
D000907:Antibodies, Bacterial