title: Serotonin 5-HT2 receptors in schizophrenic patients studied by positron emission tomography.
abstract: Using positron emission tomography (PET) and [11C]N-methylspiperone (NMSP), we examined 5-HT2 receptors in the cortex of schizophrenic patients in whom we previously observed decreased prefrontal D1 receptor binding. The subjects were 10 neuroleptic-naive schizophrenic patients, 7 schizophrenic patients who were drug-free but had previously been treated with neuroleptics, and 12 normal controls. A non-significant trend towards decreased prefrontal [11C]NMSP binding was observed in the neuroleptic-treated patients, suggesting a possible effect of previous neuroleptic treatment on the alteration in cortical 5-HT2 function. However, the neuroleptic-naive patients showed no noticeable difference in cortical [11C]NMSP binding compared to controls. Our results do not rule out the role of 5-HT2 function as a crucial site of therapeutic activity of schizophrenia, but they do suggest that cortical 5-HT2 receptors might not be primarily involved in the pathophysiology of schizophrenia.
authors.affiliation: Department of Neurobehavioral Medicine, Graduate School of Tokyo Medical and Dental University, Japan. okubo.psyc@med.tmd.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Okubo
authors.forename: T
authors.initials: T
authors.lastname: Suhara
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: O
authors.initials: O
authors.lastname: Inoue
authors.forename: O
authors.initials: O
authors.lastname: Terasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Someya
authors.forename: T
authors.initials: T
authors.lastname: Sassa
authors.forename: Y
authors.initials: Y
authors.lastname: Sudo
authors.forename: E
authors.initials: E
authors.lastname: Matsushima
authors.forename: M
authors.initials: M
authors.lastname: Iyo
authors.forename: Y
authors.initials: Y
authors.lastname: Tateno
authors.forename: M
authors.initials: M
authors.lastname: Toru
mesh_terms: D000328:Adult; D002247:Carbon Isotopes; D002540:Cerebral Cortex / Q000378:metabolism*; D006801:Humans; D011985:Receptors, Serotonin / Q000032:analysis*; D012559:Schizophrenia / Q000378:metabolism*; D013134:Spiperone / Q000031:analogs & derivatives*; D014055:Tomography, Emission-Computed
chemical_list: D002247:Carbon Isotopes; D011985:Receptors, Serotonin; D013134:Spiperone; C039167:3-N-methylspiperone