[The effect of obesity on ovarian function. I. Serum insulin and insulin dependent protein concentrations in obese patients with polycystic ovary syndrome].
OBJECTIVE
The aim of the present study was to estimate the role of insulin in the pathogenesis of polycystic ovary syndrome.


METHODS
The study was carried out in 21 obese women with PCO, 18 obese women without menstrual disturbances and 9 normal-weight healthy women.


METHODS
In all patients antropomethric parameters: weight, height, % of body fat, waist and hip girths were measured and than BMI and WHR were calculated. Oral glucose tolerance test after 75 g glucose was done after overnight fast. Plasma glucose and insulin were measured in 0 min, 60 min and 120 min of the test. The concentrations of IGF-I, IGFBP-1, SHBG, LH, FSH, testosterone, cortisol, PRL, estradiol, were estimated.


RESULTS
There was statistical significant difference between plasma insulin concentrations in obese patients with PCO in comparison to obese women with normal menstrual cycle (p < 0.05) and control group (p < 0.001). The concentrations of IGFBP-1 and SHBG were similar in both groups of obese patients and differ markedly in comparison to the control group. There were significant correlation between plasma insulin and % body fat, BMI and waist girth in all studied groups.


CONCLUSIONS
We conclude that in obese women with PCO insulin influence ovarian androgen production and decreases the serum SHBG and IGFBP-1 which could contribute in the augmentation of the symptoms of PCO.
Kinalski
M
M
Instytutu Połoznictwa i Chorób Kobiecych, Akademii Medycznej w Białymstoku.
Kowalska
I
I
Wołczyński
S
S
Straczkowski
M
M
Telejko
B
B
Kinalska
I
I
Szamatowicz
M
M
D000328:Adult; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D012720:Severity of Illness Index; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
D007328:Insulin; D018970:Insulin-Like Growth Factor Binding Protein 1; D012738:Sex Hormone-Binding Globulin