Massive rise in thyroglobulin with adult respiratory distress syndrome after embolisation of thyroid cancer metastasis.
A patient with long-standing metastatic disease from a well differentiated papillary cell carcinoma of the thyroid underwent embolisation of a painful large sacral metastasis. Following embolisation she had a massive rise in circulating serum thyroglobulin (Tg) levels coinciding with the development of adult respiratory distress syndrome (ARDS) on the tenth day without any other obvious cause. The patient subsequently recovered. The time course suggests that ARDS in this case might have resulted from aggregation of Tg molecules in the pulmonary microcirculation.
Elshafie
O
O
Department of Medicine, Sultan Qaboos University Hospital, Sultanate of Oman.
Hussein
S
S
Jeans
W D
WD
Woodhouse
N J
NJ
D002291:Carcinoma, Papillary / Q000556:secondary / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000209:etiology*; D013125:Spinal Neoplasms / Q000556:secondary / Q000628:therapy*; D013954:Thyroglobulin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000473:pathology / Q000628:therapy*
D013954:Thyroglobulin