title: Generating interactive molecular documentaries using a library of graphical actions.
abstract: Paper-based publishing of scientific articles limits the types of presentations that can be used. The emergence of electronic publishing has created opportunities to increase the range of formats available for conveying scientific content. We introduce the Graphical Explanation Markup Language, GEML, implemented as an XML format for defining molecular documentaries which exploit the interactive capabilities of electronic publishing. GEML builds upon existing molecular structure definitions such as the Protein Data Bank (PDB) standard file format. GEML provides a library of gestures (or actions) commonly used for structural explanations, and is extensible. XML allows us to separate explicit statements about how to highlight a molecular structure from the implementation of these instructions. We also present GEIS (Generator of Explanatory Interactive Systems), a program that takes as input a GEML documentary definition file and produces all the files necessary for an interactive, web-based molecular documentary. To demonstrate GEML and GEIS, we constructed a documentary capturing the difficult 3D notions expressed in two selected published reports about human topoisomerase I. We have created a prototype Java application, GEMLBuilder, as an editor of GEML files.
authors.affiliation: Stanford Medical Informatics, Stanford University, CA 94305-5479, USA. prasanth@smi.stanford.edu
authors.forename: P
authors.initials: P
authors.lastname: Pulavarthi
authors.forename: R
authors.initials: R
authors.lastname: Chiang
authors.forename: R B
authors.initials: RB
authors.lastname: Altman
mesh_terms: D003196:Computer Graphics; D004264:DNA Topoisomerases, Type I / Q000737:chemistry; D016208:Databases, Factual; D006801:Humans; D008958:Models, Molecular; D019212:Multimedia; D011381:Programming Languages; D011643:Publishing; D012984:Software
chemical_list: D004264:DNA Topoisomerases, Type I