Designing chiral libraries for drug discovery.
Identification of new biological targets combined with combinatorial medicinal chemistry has enormous potential to facilitate the discovery of new therapeutics. However, these new targets might require the use of different or more complex screening libraries. This complexity might be achieved through the use of new templates or the identification of new chemistries. One approach is the use of chiral libraries that have been designed using three-dimensional pharmacophore and shape descriptors to provide maximal structure-activity information after screening. The advantages of using a designed chiral library in primary screening and the information one should obtain are discussed.
Beroza
P
DuPont Pharmaceuticals Research Laboratories, 4570 Executive Drive, Suite 400, San Diego, CA 92121, USA.
Suto
MJ