Functional domains, structural variations and pathogen interactions of MCP, DAF and CR1.
The Regulators of Complement Activation (RCA) are a fascinating group of proteins that play important roles in innate and acquired immunity. In this review, we examine structure-function aspects of three membrane-bound RCA proteins and discuss the unique impact of their genetic organization on their evolution.
Hourcade
D
D
Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Liszewski
M K
MK
Krych-Goldberg
M
M
Atkinson
J P
JP
D000818:Animals; D015703:Antigens, CD / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D005075:Biological Evolution; D018958:CD55 Antigens / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D003167:Complement Activation; D014644:Genetic Variation; D006801:Humans; D007239:Infections / Q000276:immunology; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D017434:Protein Structure, Tertiary; D017463:Receptors, Complement 3b / Q000737:chemistry* / Q000235:genetics / Q000502:physiology
D015703:Antigens, CD; C497857:CD46 protein, human; D018958:CD55 Antigens; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D017463:Receptors, Complement 3b