The use of zeolites as slow release anthelmintic carriers.
This work examines the ability of commercial zeolite Y to act as a slow release agent for a number of anthelmintic drugs. Administration to rats, dosed with Nippostrongylus brasiliensis, of pyrantel and/or fenbendazole and pigs, dosed with Ascaris and Oesophagostomum, of dichlorvos (DDVP) loaded onto zeolite Y was more successful in killing adult worms than administration of the pure drug alone. The zeolite Y was used as supplied for initial studies and then later dealuminated for further studies. The drug loadings were monitored by thermal analysis and the loaded zeolites were used in several field trials. The results indicate that zeolite Y is a suitable vehicle for the slow release of some anthelmintics. The slow release of drug from the zeolite matrix improved its efficacy.
Dyer
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A
Department of Chemistry, University of Salford, Salford, Lancashire, M5 4WT, UK.
Morgan
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S
Wells
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P
Williams
C
C
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004006:Dichlorvos / Q000008:administration & dosage / Q000627:therapeutic use; D004337:Drug Carriers; D004355:Drug Stability; D005260:Female; D005273:Fenbendazole / Q000008:administration & dosage / Q000627:therapeutic use; D006374:Helminthiasis, Animal / Q000188:drug therapy*; D008297:Male; D011716:Pyrantel Pamoate / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013552:Swine; D017641:Zeolites
D000871:Anthelmintics; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D017641:Zeolites; D005273:Fenbendazole; D004006:Dichlorvos; D011716:Pyrantel Pamoate