Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic.
This review provides both a biological and clinical perspective on Time-Dependent Sensitization (TDS), an ancient amplified memory response to threat manifest in the ability of both drugs and nondrug stressors to induce neuronal and behavioral effects which strengthen entirely as a function of the passage of time following even a single or acute exposure. Evidence is presented to show that TDS may be involved in the development of a spectrum of diseases and how drug regimens based on the principles of TDS could provide a novel and revolutionary means of treating psychiatric and other illnesses.
Antelman
S M
SM
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA. antelmansm@msx.upmc.edu
Levine
J
J
Gershon
S
S
D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced / Q000188:drug therapy*; D011570:Psychiatry / Q000639:trends*; D020551:Pulse Therapy, Drug / Q000639:trends*
D014150:Antipsychotic Agents