title: Percutaneous image-guided biopsy of lung nodules in the assessment of disease activity in Wegener's granulomatosis.
abstract: OBJECTIVE
  In patients with known Wegener's granulomatosis (WG) and persistent chest radiographic abnormalities, assessment for disease activity is often difficult, prompting the need for histological diagnosis to determine appropriate treatment. Here we report the use of automated image-guided core needle biopsy of pulmonary lesions for the assessment of disease activity in WG, rather than for primary diagnosis.
  
  
  METHODS
  Image-guided percutaneous core needle biopsy was performed on five occasions in four patients with thoracic WG and persistent radiographic abnormalities of the chest. Clinical features, indication for biopsy, radiographic abnormalities and pathological findings were recorded.
  
  
  RESULTS
  Adequate pathological specimens were obtained, allowing exclusion of infection and tumour. Active chronic inflammation with or without vasculitis was demonstrated in each case, indicating the need for further immunosuppressive therapy. A small pneumothorax following biopsy in one case required no treatment. Follow-up chest imaging revealed a reduction in the extent of thoracic disease following therapy in all cases.
  
  
  CONCLUSIONS
  The safety and diagnostic accuracy of image-guided core biopsy of thoracic lesions makes it a useful tool in the assessment of disease activity in WG patients with persistent chest radiographic lesions.
authors.affiliation: Department of Rheumatology, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TT, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Carruthers
authors.forename: S
authors.initials: S
authors.lastname: Connor
authors.forename: A J
authors.initials: AJ
authors.lastname: Howie
authors.forename: A R
authors.initials: AR
authors.lastname: Exley
authors.forename: K
authors.initials: K
authors.lastname: Raza
authors.forename: P A
authors.initials: PA
authors.lastname: Bacon
authors.forename: P
authors.initials: P
authors.lastname: Guest
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D018450:Disease Progression; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*