Serum myoglobin and creatine kinase following surgery.
Serum myoglobin (by radioimmunoassay) and creatine kinase were measured for up to 7 days in 30 patients following surgical procedures, including total hip replacement and bilateral subcostal abdominal incisions. Serum myoglobin reached a maximum of 1390 micrograms litre-1 (median 345 micrograms litre-1 for major surgery patients) on the first postoperative day but levels were still elevated by day 7 in some patients. Creatine kinase reached a maximum of 1339 i.u. litre-1 at day 2 (median 422 i.u. litre-1 for major surgery patients), generally peaking 1 day after myoglobin in individual patients. These values may have significance when investigating a suspicion of coincident perioperative events such as myocardial infarction or malignant hyperthermia.
Laurence
A S
AS
Northern General Hospital, Sheffield, UK.
D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D013511:Minor Surgical Procedures; D018482:Muscle, Skeletal / Q000601:surgery; D009211:Myoglobin / Q000097:blood*; D011184:Postoperative Period; D013514:Surgical Procedures, Operative
D015415:Biomarkers; D009211:Myoglobin; D003402:Creatine Kinase