title: Pepsinogen C expression in tumors of extragastric origin.
abstract: We have examined by immunohistochemistry the ability of human carcinomas of various origin to produce pepsinogen C, an aspartyl proteinase mainly involved in the digestion of proteins in the stomach and recently found to be associated with breast carcinomas. Of the 268 tumors analyzed 80 (29.8%) showed positive staining for pepsinogen C. These positive tumors included 12 gastric (38.7% of the 31 examined cases), nine pancreatic (42.8%), two renal (20%), 12 prostatic (40%), three bladder (27.3%), 14 endometrial (29.7%) and 18 ovarian (40%) carcinomas. We also detected 10 melanomas (50%) that were positive for pepsinogen C. By contrast, immunohistochemical staining for the proteinase was not detected in colorectal, cervical, lung and basal cell skin carcinomas. These results demonstrate that pepsinogen C, a proteolytic enzyme of highly restricted expression in human tissues, can also be expressed by a wide variety of human carcinomas. In addition, and similar to pepsinogen C expression in breast carcinomas, the production of this enzyme by different human tumors might be related to putative hormonal alterations associated with the development and progression of these tumors.
authors.affiliation: Department of Pathology, Hospital de Cabueñes, Gijón, Spain.
authors.forename: A M
authors.initials: AM
authors.lastname: Merino
authors.forename: J
authors.initials: J
authors.lastname: Vázquez
authors.forename: J C
authors.initials: JC
authors.lastname: Rodríguez
authors.forename: R
authors.initials: R
authors.lastname: Fernández
authors.forename: I
authors.initials: I
authors.lastname: Quintela
authors.forename: L O
authors.initials: LO
authors.lastname: González
authors.forename: L M
authors.initials: LM
authors.lastname: Sánchez
authors.forename: F
authors.initials: F
authors.lastname: Vizoso
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology; D002277:Carcinoma / Q000201:enzymology*; D004067:Digestive System Neoplasms / Q000201:enzymology; D005260:Female; D005833:Genital Neoplasms, Female / Q000201:enzymology; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000201:enzymology; D009363:Neoplasm Proteins / Q000032:analysis*; D009369:Neoplasms / Q000201:enzymology*; D009928:Organ Specificity; D020115:Pepsinogen C / Q000032:analysis*; D012878:Skin Neoplasms / Q000201:enzymology; D014565:Urogenital Neoplasms / Q000201:enzymology
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D020115:Pepsinogen C