title: Determination of clopidol residues in chicken tissues by high-performance liquid chromatography-mass spectrometry.
abstract: A high-performance liquid chromatographic-mass spectrometric (HPLC-MS) method has been developed for determination of clopidol residues in chicken tissues. Samples are extracted with acetonitrile. The extracts are cleaned up on an alumina column followed by an anion-exchange column. The clopidol is separated on a column (150 cmx4.6 mm) of Intertsil by using acetonitrile-water (20:80) as mobile phase. The clopidol was qualitatively identified by molecule mass and determined quantitatively by selected ion monitoring mode at 190 m/z. The recoveries with RSDs ranged from 91.6+/-10.1 to 97.3+/-5.7 at 0.010 to 10.0 mg/kg by spiking three matrices (chicken muscle, liver, and kidney). The limit of detection was 0.005 mg/kg, and the limit of quantification was 0.010 mg/kg.
authors.affiliation: Qinhuangdao Import & Export Commodity Inspection Bureau, P.C., China.
authors.forename: G F
authors.initials: GF
authors.lastname: Pang
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Cao
authors.forename: C L
authors.initials: CL
authors.lastname: Fan
authors.forename: J J
authors.initials: JJ
authors.lastname: Zhang
authors.forename: X M
authors.initials: XM
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Wang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003007:Clopidol / Q000032:analysis*; D003049:Coccidiostats / Q000032:analysis*; D004350:Drug Residues / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003049:Coccidiostats; D003007:Clopidol