title: Glutamate is the afferent neurotransmitter in the human cochlea.
abstract: Glutamate, the most important afferent neurotransmitter in the auditory system, is thought to be the afferent transmitter between the cochlear inner hair cells and afferent neurons, hitherto visualized only in the cochlea of animal species. It has been identified for the first time in sections from the human inner ear. L-glutamate, NMDAR2B and the enzyme glutamine synthetase were identified by using monoclonal antibodies. The distribution pattern of the transmitter L-glutamate in the human cochlea is similar to that observed in other mammals. L-glutamate was identified adjacent to outer and inner hair cells and in the spiral ganglion. Similar distributions were found for glutamine synthetase and the ionotropic NMDA receptor subunit NMDAR2. The identification of neurotransmitters and their receptors in the human cochlea has implications for the pharmacotherapy of inner ear diseases.
authors.affiliation: Department of Otolaryngology and Head & Neck Surgery, Uppsala University Hospital, Sweden. leif.nordang@ent.uas.lul.se
authors.forename: L
authors.initials: L
authors.lastname: Nordang
authors.forename: E
authors.initials: E
authors.lastname: Cestreicher
authors.forename: W
authors.initials: W
authors.lastname: Arnold
authors.forename: M
authors.initials: M
authors.lastname: Anniko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003051:Cochlea / Q000378:metabolism*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006199:Hair Cells, Auditory, Inner / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009475:Neurons, Afferent / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013136:Spiral Ganglion / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid