Highly concentrated vascular endothelial growth factor in platelets in Crow-Fukase syndrome.
We report a marked difference in concentration of vascular endothelial growth factor (VEGF) between serum and plasma in patients with Crow-Fukase syndrome (CFS). The serum/plasma VEGF levels in 4 CFS patients were 8,634/152, 5,203/176, 3,724/127, and 868/13 pg/ml, respectively. We also showed that platelets were a major source of this VEGF and that VEGF was released during platelet aggregation by physiological stimulation. It is suggested that in CFS, local VEGF concentration is markedly elevated by aggregation of platelets containing excessive VEGF and their adhesion to vascular walls, resulting in excessive physiological activities of VEGF. Our findings provide important information for developing more effective therapeutic trials.
Hashiguchi
T
T
Third Department of Internal Medicine, Kagoshima University, School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520 Japan. terutoha@khosp3.kufm.kagoshima-u.ac.jp
Arimura
K
K
Matsumuro
K
K
Otsuka
R
R
Watanabe
O
O
Jonosono
M
M
Maruyama
Y
Y
Maruyama
I
I
Osame
M
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology; D016228:Endothelial Growth Factors / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000097:blood*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D016878:POEMS Syndrome / Q000097:blood* / Q000188:drug therapy; D015539:Platelet Activation / Q000187:drug effects; D010974:Platelet Aggregation / Q000502:physiology; D010976:Platelet Count; D013917:Thrombin / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D000893:Anti-Inflammatory Agents; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000244:Adenosine Diphosphate; D013917:Thrombin; D002118:Calcium; D008775:Methylprednisolone