title: Alkyl and alkoxycarbonyl derivatives of ginkgolide B: synthesis and biological evaluation of PAF inhibitory activity.
abstract: Alkyl and alkoxycarbonyl derivatives 6-24 of ginkgolide B, prepared in one step from ginkgolide B through alkylation and acylation and evaluated for their in vitro ability to inhibit the PAF-induced aggregation of rabbit platelets, show equivalent or superior activities to ginkgolide B.
authors.affiliation: Shanghai Institute of Materia Medica, Academia Sinica, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Hu
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Xie
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: H
authors.initials: H
authors.lastname: Zhen
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011817:Rabbits; D013057:Spectrum Analysis
chemical_list: D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; C045856:ginkgolide B