A molecular NAND gate based on Watson-Crick base pairing.
[reaction: see text] A DNA-binding dye, 4',6-diamidino-2-phenylindole (DAPI) signals AT base pairing with a shift in the fluorescence emission spectrum. The signaling follows W-C base-pairing rules, and both dAMP and dTMP are required for the largest spectral shift. Thus, the dye with its two phosphate receptor sites functions as a molecular NAND gate accepting nucleotides as inputs. Moreover, when the observation wavelength is changed from 470 to 411.5 nm, the gate functions in TRANSFER logic.
Baytekin
H T
HT
Middle East Technical University, Department of Chemistry, Ankara, Turkey.
Akkaya
E U
EU
D000249:Adenosine Monophosphate / Q000737:chemistry / Q000378:metabolism; D020029:Base Pairing / Q000187:drug effects*; D004735:Energy Transfer / Q000187:drug effects*; D005456:Fluorescent Dyes / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D007254:Information Science; D007257:Information Theory; D007364:Intercalating Agents / Q000494:pharmacology; D013938:Thymidine Monophosphate / Q000737:chemistry / Q000378:metabolism
D005456:Fluorescent Dyes; D007211:Indoles; D007364:Intercalating Agents; D013938:Thymidine Monophosphate; D000249:Adenosine Monophosphate; C007293:DAPI