IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. II. Physico-chemical properties and structure determination.
IB-96212, is a new member of spiroketal containing macrolide class of fermentation-derived natural products isolated from mycelial extracts of Micromonospora sp. The structure consists of a new aglycone which possesses a 26-membered macrolide ring system and of one deoxy sugar identified as L-rhodinose, this structure represents the first reported spiroketal macrolide natural product related to other macrolides, such as oligomycins, dunaimycins, citovaricin, rutamycin and ossamycin.
Cañedo
L M
LM
Drug Discovery Division, Instituto Biomar SA, León, Spain.
Fernández-Puentes
J L
JL
Baz
J P
JP
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D018942:Macrolides; D008847:Micromonospora / Q000378:metabolism*; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013057:Spectrum Analysis
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; C411677:IB 96212; D018942:Macrolides