title: Human herpesvirus-6 (HHV-6)-associated hemophagocytic syndrome.
abstract: Virus-associated hemophagocytic syndrome (VAHS) is characterized by histiocytic proliferation and phagocytosis triggered by virus infections. Viruses in the herpes group, especially the Epstein-Barr virus (EBV), are well known to cause VAHS; however, the relationship between this syndrome and human herpesvirus-6 (HHV-6) infection has rarely been reported. In this study, we describe a 23-month-old girl who exhibited typical manifestations of VAHS associated with HHV-6 infection. To the best of our knowledge, this case is the fifth reported case in the English literature.
authors.affiliation: Department of Pediatrics, Koshigaya Municipal Hospital, Saitama, Japan. mtakagi@nch.go.jp
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: A
authors.initials: A
authors.lastname: Unno
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Obinata
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001778:Blood Coagulation Disorders / Q000209:etiology; D004279:DNA, Viral / Q000097:blood; D005076:Exanthema / Q000209:etiology; D005260:Female; D005334:Fever / Q000209:etiology; D006529:Hepatomegaly / Q000209:etiology; D006566:Herpesviridae Infections / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D010198:Pancytopenia / Q000209:etiology; D012887:Skull Fractures / Q000150:complications; D013163:Splenomegaly / Q000209:etiology; D014766:Viremia / Q000150:complications* / Q000175:diagnosis
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D007075:Immunoglobulin M