Glucose-6-phosphate dehydrogenase deficiency-induced hemolysis in newly diagnosed diabetic monozygotic twins.
A pair of monozygotic male twins are described who manifested hemolysis at the concurrent onset of diabetes type 1. Hemolysis appeared progressively following the correction of hyperglycemia and ketoacidosis (one twin). It was found to be related to unknown glucose 6-phosphate dehydrogenase (G-6-PD) deficiency. Other causes of hemolysis such as drugs or bacterial infection were excluded. The fall in glucose availability after the correction of hyperglycemia is proposed as a possible explanation for hemolysis.
Galli-Tsinopoulou
A
A
4th Pediatric Department, Aristotle University of Thessaloniki, Greece. galtsin@otenet.gr
Nousia-Arvanitakis
S
S
D000743:Anemia, Hemolytic / Q000201:enzymology*; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy; D004200:Diseases in Twins; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D014430:Twins, Monozygotic
D007328:Insulin