Paracoccidioidomycosis (South American blastomycosis) successfully treated with terbinafine: first case report.
We describe a 63-year-old man who presented with painful malodorous lesions in the perianal, perineal and scrotal regions. Following definitive diagnosis of paracoccidioidomycosis, he was treated initially with trimethoprim/sulphamethoxazole, but there was no clinical improvement. He then received terbinafine (Lamisil) 250 mg twice daily for 6 months. There was rapid resolution of all lesions and complete relief of symptoms, without any associated side-effects. The patient remains clinically well and without any evidence of infection 2 years after discontinuation of terbinafine treatment.
Ollague
J M
JM
Department of Dermatology, Venereology and Allergy, IESS University of Guayaquil, PO Box 09-01-8611, Guayaquil, Ecuador. jollague@gye.satnet.net
de Zurita
A M
AM
Calero
G
G
D000935:Antifungal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use*; D010229:Paracoccidioidomycosis / Q000188:drug therapy*; D010502:Perineum; D012611:Scrotum; D000077291:Terbinafine; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000935:Antifungal Agents; D009281:Naphthalenes; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000077291:Terbinafine