Acquired Immunodeficiency Syndrome-Related Non-Hodgkin Lymphoma.
Non-Hodgkin lymphoma affects 5% to 10% of patients with acquired immunodeficiency syndrome (AIDS) in the United States. Usually of B-cell or indeterminate phenotype and high-grade histology, the disease shows a predilection to involve extranodal sites such as the bone marrow and the central nervous system. The pathogenesis involves chronic antigen stimulation producing B-cell hyperplasia in a setting of progressive immunologic deterioration. Treatment is not standardized and is tailored to the patient's immune function and clinical status. New approaches, validated by clinical trials, are needed.
Remick
SC
Division of Medical Oncology and HIV Medicine, Albany Medical College, Albany, New York 12208, USA.