Delayed generalized allergic reactions to corticosteroids.
A 37-year-old patient presented with a severe allergic local reaction upon inhalation of budesonide for asthma. Skin tests were positive for budesonide and amcinonide (group B) and elicited a strong local reaction and a disseminated macular exanthema. Corticosteroids from other groups were well tolerated. A 38-year-old male patient had first an allergic contact dermatitis to topically applied prednisolone acetate and then a disseminated eczematous exanthema upon oral intake of prednisone. A delayed-type sensitization to corticosteroids from group A such as hydrocortisone, prednisone and tixocortol pivalate was identified. A detailed diagnosis in patients with allergic reactions to corticosteroids is crucial with regard to their use in emergency therapy.
Bircher
A J
AJ
Allergy Clinic, Department of Dermatology, University Hospital Basel, Switzerland. Andreas.Bircher@unibas.ch
Bigliardi
P
P
Zaugg
T
T
Mäkinen-Kiljunen
S
S
D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000188:drug therapy; D019819:Budesonide / Q000009:adverse effects / Q000627:therapeutic use; D003872:Dermatitis / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010328:Patch Tests; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000473:pathology
D000305:Adrenal Cortex Hormones; D019819:Budesonide; D011239:Prednisolone