title: Correlation between erythropoietin and lactate in humans during altitude exposure.
abstract: The plasma concentrations of both immunoreactive erythropoietin (EPO) and lactate were determined in four healthy untrained subjects at sea level and on the 2nd or 3rd day at altitudes (1,300 and 3,500 m). The mean plasma EPO (18.8 +/- 1.6 mU/ml at sea level) increased significantly on the 3rd day at 1,300 m (25.5 +/- 2.0 mU/ml, p < 0. 05) and showed an almost three-fold increase on the 2nd day at 3,500 m (53.5 +/- 3.7 mU/ml, p < 0.001). Likewise, the mean plasma lactate at 3,500 m (3.98 +/- 0.27 mmol/l) was 3.6 times as high as that at sea level (1.11 +/- 0.05 mmol/l) (p < 0.001). The plasma EPO concentrations were found to correlate well with the lactate concentrations at sea level and altitudes (r = 0.86, p < 0.01). These results are consistent with the well-known EPO/lactate response to altitudes and suggest that the circulating EPO concentration as well as blood lactate concentration can be used as an index of anaerobic condition.
authors.affiliation: Department of Physiology II, College of Nursing, Nara Medical University, Kashihara, Japan. ssakata@naramed-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Sakata
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Kishi
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: I
authors.initials: I
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Ohno
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: M
authors.initials: M
authors.lastname: Takaki
authors.forename: H
authors.initials: H
authors.lastname: Kohzuki
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: I
authors.initials: I
authors.lastname: Shimamoto
authors.forename: S
authors.initials: S
authors.lastname: Yanagi
authors.forename: K
authors.initials: K
authors.lastname: Ogoshi
authors.forename: J B
authors.initials: JB
authors.lastname: Sherchand
mesh_terms: D000328:Adult; D000531:Altitude; D001274:Atmospheric Pressure; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D004921:Erythropoietin; D019344:Lactic Acid