title: Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production.
abstract: To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recruitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility.
authors.affiliation: Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Fruscella
authors.forename: M
authors.initials: M
authors.lastname: Romano
authors.forename: D
authors.initials: D
authors.lastname: Albani
authors.forename: S
authors.initials: S
authors.lastname: Bernasconi
authors.forename: W
authors.initials: W
authors.lastname: Luini
authors.forename: A
authors.initials: A
authors.lastname: Bruno
authors.forename: M
authors.initials: M
authors.lastname: Salmona
authors.forename: L
authors.initials: L
authors.lastname: Diomede
mesh_terms: D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins; D002465:Cell Movement / Q000276:immunology; D018932:Chemokine CCL2 / Q000096:biosynthesis*; D002784:Cholesterol / Q000276:immunology; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000276:immunology; D006903:Hydroxymethylglutaryl CoA Reductases / Q000502:physiology*; D006937:Hypercholesterolemia / Q000201:enzymology* / Q000276:immunology; D007962:Leukocytes / Q000276:immunology* / Q000502:physiology; D008297:Male; D051379:Mice; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000276:immunology; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D018932:Chemokine CCL2; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C497388:Srebf1 protein, mouse; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases