title: Reversible left ventricular dysfunction associated with raised troponin I after subarachnoid haemorrhage does not preclude successful heart transplantation.
abstract: Transient abnormalities in ECGs, echocardiograms, and cardiac enzymes have been described in the acute setting of subarachnoid haemorrhage. In addition, left ventricular dysfunction has been reported at the time of brain death. A patient with an acute subarachnoid haemorrhage who presented with raised troponin I (TnI) concentrations and diffuse left ventricular dysfunction is described. After declaration of brain death 32 hours later, the heart was felt initially not suitable for transplantation. A normal cardiac catheterisation, however, lead to successful transplantation of the donor heart. Raised catecholamine concentrations and metabolic perturbations have been proposed as the mechanisms leading to the cardiac dysfunction seen with brain death. This may be a biphasic process, allowing time for myocardial recovery and reversal of the left ventricular dysfunction. Awareness of this phenomenon in the acutely ill neurologic population needs to be raised in order to prevent the unnecessary rejection of donor hearts.
authors.affiliation: Neurology/Neurosurgery Intensive Care Unit, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA. deiberte@neuro.wustl.edu
authors.forename: E
authors.initials: E
authors.lastname: Deibert
authors.forename: V
authors.initials: V
authors.lastname: Aiyagari
authors.forename: M N
authors.initials: MN
authors.lastname: Diringer
mesh_terms: D015415:Biomarkers / Q000097:blood; D001926:Brain Death / Q000097:blood; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000601:surgery; D000075202:Contraindications; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood*; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000209:etiology*
chemical_list: D015415:Biomarkers; D019210:Troponin I