title: Preliminary study of continuous glucose monitoring with a microdialysis technique and a null method--a numerical analysis.
abstract: Monitoring of the subcutaneous tissue glucose concentration is an attractive method for continuous monitoring of the glucose concentration in diabetic patients. Several researchers have studied this, but no satisfactory method has been developed. We have proposed a new method, which can measure the glucose concentration of subcutaneous tissue continuously, even as the efficiency of membrane perfusion and sensor performance decline. Two reference solutions were prepared with concentrations higher and lower than the objective solution. They were perfused alternately for different ratios of perfusion times. The glucose concentration, after perfusing microdialysis, was detected and the trend of changes in the concentration was used to control the ratio of the two perfusion solutions. When the trend was a unity, the glucose concentration was calculated from the ratio of the two perfusion solutions. The numerical study was performed with a compartment model and a basic control theory. In simulation, the 90% response time to step change was approximately 7 min, which is fast enough when compared with the fluctuation of glucose in the electrolyte. This result suggested that this new system might be useful for continuous monitoring of the glucose concentration in subcutaneous tissue.
authors.affiliation: Institute for Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Koseki
authors.forename: T
authors.initials: T
authors.lastname: Sumino
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Togawa
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
mesh_terms: D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood*; D005947:Glucose / Q000032:analysis*; D006801:Humans; D017551:Microdialysis; D008962:Models, Theoretical
chemical_list: D001786:Blood Glucose; D005947:Glucose