title: Apraxic agraphia due to thalamic infarction.
abstract: The authors report a patient of pure apraxic agraphia with normal praxis due to left thalamic infarction. 15O-gas-PET showed reduced oxygen metabolism in the left thalamus and the left dorsolateral premotor area, while MRI and 11C-fulumazenil-PET showed no remarkable lesions in the frontal cortex. The patient's word imaging remained normal. The authors hypothesize that thalamic destruction causes pure apraxic agraphia by exerting a remote effect on left dorsolateral premotor area and blocking somewhere between graphemic area and motor programming.
authors.affiliation: Department of Neurology, Tokyo Metropolitan Geriatric Hospital, Japan. ttakae-tky@umin.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: M
authors.initials: M
authors.lastname: Bando
authors.forename: H
authors.initials: H
authors.lastname: Nagura
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Yamanouchi
mesh_terms: D000368:Aged; D000381:Agraphia / Q000175:diagnosis / Q000209:etiology*; D020520:Brain Infarction / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D020645:Mediodorsal Thalamic Nucleus / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology*; D009483:Neuropsychological Tests; D013786:Thalamic Diseases / Q000150:complications* / Q000175:diagnosis; D014055:Tomography, Emission-Computed