title: Invasive disease due to group B streptococcal infection in adults: results from a Canadian, population-based, active laboratory surveillance study--1996. Sentinel Health Unit Surveillance System Site Coordinators.
abstract: In 1996, a population-based surveillance program for invasive adult group B streptococcal (GBS) diseases in Canada was undertaken, to define the epidemiologic and microbiologic characteristics of the disease. Nine public health units across Canada, representing 9.6% of the population, participated in the program. In total, 106 culture-positive cases of invasive adult GBS disease were reported, which represented an incidence rate 4.6 per 100,000 adults (41/100, 000 for pregnant and 4.1/100,000 for nonpregnant adults). Sixty-two (58.5%) of the 106 cases occurred in females, and, of these, 15 (14. 2%) were associated with pregnancy. Serotype V was the most common, accounting for 31% of the 90 GBS isolates typed (26.7% of nonpregnant and 4.4% of pregnant cases). This was followed by serotypes III (19%), Ia (17%), Ib (10%), II (9%), and VII (1%). Thirteen percent were nontypeable. All isolates were susceptible to penicillin, ampicillin, and vancomycin. Resistance to erythromycin and clindamycin was 6.7% and 4.4%, respectively.
authors.affiliation: Walter Mackenzie Centre, Edmonton, Alberta, Canada T6G 2J2. gjt@bugs. uah.ualberta.ca. gjt@bugs.uah.ualbert.ca
authors.forename: G J
authors.initials: GJ
authors.lastname: Tyrrell
authors.forename: L D
authors.initials: LD
authors.lastname: Senzilet
authors.forename: J S
authors.initials: JS
authors.lastname: Spika
authors.forename: D A
authors.initials: DA
authors.lastname: Kertesz
authors.forename: M
authors.initials: M
authors.lastname: Alagaratnam
authors.forename: M
authors.initials: M
authors.lastname: Lovgren
authors.forename: J A
authors.initials: JA
authors.lastname: Talbot
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002170:Canada / Q000453:epidemiology; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000494:pharmacology; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D015203:Reproducibility of Results; D012703:Serotyping; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000276:immunology / Q000401:mortality / Q000503:physiopathology; D013292:Streptococcus agalactiae / Q000187:drug effects / Q000276:immunology
chemical_list: D010406:Penicillins