[Mechanism of progression of chronic renal failure and new treatment strategies].
Chronic renal failure is a self-perpetuating, progressive disease leading to end-stage renal failure, even if primary insult to the kidneys was removed. Progressive course of disease is caused by chronic interstitial inflammation leading to fibrosis, tubular atrophy, and glomerular sclerosis. Main predictive risk factors of the disease progression include: proteinuria, systemic and glomerular hypertension. It is presumed that in most cases progressive course of the disease is related to genetic predisposition to greater activity of renin-angiotensin system. Among attempts to slow progressive course of the disease effective are interventions acting on renin-angiotensin system, endothelin 1 and on profibrotic cytokines. Role of dietary factors and potential treatment modalities are discussed.
Litwin
M
M
Kliniki Dializoterapii i Transplantacji Nerek Instytut-Pomnik Centrum Zdrowia Dziecka w Warszawie.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D018450:Disease Progression; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000037:antagonists & inhibitors*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000503:physiopathology*
D000806:Angiotensin-Converting Enzyme Inhibitors; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1