[Synthesis of uracil and theophylline derivatives and study of their effect on glucose transport in rat hepatic cells].
A series of uracil and theophyllin derivatives were synthesized. 4-Amino-1,3-dimethyl-5-nonanoylaminouracil displayed the most pronounced effect of the in vitro stimulation of the 2-deoxyglucose transport into hepatic rat cells.
Leonov
O N
ON
Institute of Biological Medicine, Moscow, Russia.
Tsirenina
M L
ML
Mel'nik
E I
EI
Devichenskiĭ
V M
VM
Kriukova
L Iu
LIu
Vorontsov
E A
EA
Kuznetsov
S L
SL
Kriukov
L N
LN
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002478:Cells, Cultured; D003847:Deoxyglucose / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D010726:Phosphodiesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013806:Theophylline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D010726:Phosphodiesterase Inhibitors; D014498:Uracil; D003847:Deoxyglucose; D013806:Theophylline