title: Synthesis and biological properties of new 1beta-methylcarbapenems having tetrazolothioether moiety.
abstract: The synthesis and biological activities of a series of new 1beta-methylcarbapenems 1a-l having tetrazolothioether moiety at C-5 position of pyrrolidine were described. Among these compounds, 1c showed the most potent antibacterial activity and advanced pharmacokinetics compared with imipenem and meropenem.
authors.affiliation: Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, South Korea.
authors.forename: K J
authors.initials: KJ
authors.lastname: Shin
authors.forename: K D
authors.initials: KD
authors.lastname: Koo
authors.forename: K H
authors.initials: KH
authors.lastname: Yoo
authors.forename: D C
authors.initials: DC
authors.lastname: Kim
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: S W
authors.initials: SW
authors.lastname: Park
mesh_terms: D000818:Animals; D015780:Carbapenems / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D015780:Carbapenems