title: Resting energy expenditure, growth hormone indices, body composition and adipose tissue distribution in premenopausal women.
abstract: OBJECTIVE
  A significant growth hormone (GH) contribution to interindividual variance in energy expenditure (REE) in women can be hypothesized. The present study examines the independent association between physiological levels of GH function indices and REE.
  
  
  METHODS
  All subjects were hospitalized in the Institute of Internal Medicine of the University of Verona.
  
  
  METHODS
  Twenty-four premenopausal overweight (BMI = 28-55 kg m-2) women aged 18-49 years.
  
  
  METHODS
  REE was estimated by indirect calorimetry and body composition and fat distribution by single slice computed tomography method. GH activity and GH status were determined by measuring serum levels of insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3).
  
  
  RESULTS
  GH indices did not show any significant correlation with REE. The relation between GH indices and REE was also examined by multiple regression analysis to account for possible confounders such as body composition, adipose tissue distribution and age. When body composition was considered, body fat and fat-free mass were the only significant predictors of REE (R2 = 0.699, P = 0.0001). The contributions of GH indices were not significant.
  
  
  CONCLUSIONS
  Our findings do not support the hypothesis that GH in physiological conditions could be an independent determinant of REE in women with obesity.
authors.affiliation: Geriatrics Division, San Lorenzo Hospital, Valdagno; the Institute of Geriatrics, University of Verona, Verona, Italy. farmel@tin.it
authors.forename: F
authors.initials: F
authors.lastname: Armellini
authors.forename: M
authors.initials: M
authors.lastname: Zamboni
authors.forename: G
authors.initials: G
authors.lastname: De Pergola
authors.forename: L
authors.initials: L
authors.lastname: Bissoli
authors.forename: E
authors.initials: E
authors.lastname: Turcato
authors.forename: R
authors.initials: R
authors.lastname: Giorgino
authors.forename: O
authors.initials: O
authors.lastname: Bosello
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D001481:Basal Metabolism; D001823:Body Composition; D001824:Body Constitution; D002153:Calorimetry, Indirect; D005260:Female; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism* / Q000473:pathology*; D017697:Premenopause / Q000378:metabolism
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I