Hippocampal and striatal [(3)H]5-HT reuptake under acute stressors in two rat strains differing for their emotivity.
Spontaneously hypertensive rats and Lewis rats differ in their anxiety levels and in their serotonergic and corticotropic responses to stress. Since the 5-HT transporter plays a key role in 5-HT neurotransmission, we have analyzed whether hippocampal and/or striatal [(3)H]5-HT reuptake kinetics are altered by stress in a strain-dependent manner. It was found that forced swimming, treadmill running, or restraint for 30 min affected neither hippocampal nor striatal [(3)H]5-HT reuptake K(m) and V(max) values in the two rat strains. This study, which is the first to examine the impact of acute stress on [(3)H]5-HT reuptake with respect to the nature of the stressor, the brain region analyzed, and the rat strain, could reinforce the hypothesis that extracellular 5-HT levels during stress are representative of 5-HT release.
Martin
C
C
Laboratoire de Physiologie de l'Exercice Musculaire et du Sport, Université Bordeaux II, 33076, Bordeaux, France.
Duclos
M
M
Mormède
P
P
Manier
G
G
Chaouloff
F
F
D000818:Animals; D001007:Anxiety / Q000378:metabolism* / Q000523:psychology; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology; D005080:Exercise Test; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011918:Rats, Inbred SHR; D012146:Rest; D012149:Restraint, Physical; D012420:Running / Q000502:physiology; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology; D013550:Swimming / Q000502:physiology
D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors