The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease.
One of the theories involved in the etiology of Alzheimer's disease (AD) is the oxidative stress hypothesis. The amyloid beta-peptide (A beta), a hallmark in the pathogenesis of AD and the main component of senile plaques, generates free radicals in a metal-catalyzed reaction inducing neuronal cell death by a reactive oxygen species mediated process which damage neuronal membrane lipids, proteins and nucleic acids. Therefore, the interest in the protective role of different antioxidants in AD such as vitamin E, melatonin and estrogens is growing up. In this review we summarize data that support the involvement of oxidative stress as an active factor in A beta-mediated neuropathology, by triggering or facilitating neurodegeneration, through a wide range of molecular events that disturb neuronal cell homeostasis.
Miranda
S
S
Centro de Regulación Celular y Patología, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago, Chile.
Opazo
C
C
Larrondo
L F
LF
Muñoz
F J
FJ
Ruiz
F
F
Leighton
F
F
Inestrosa
N C
NC
D000544:Alzheimer Disease / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D008670:Metals / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology; D009696:Nucleic Acids / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism
D016229:Amyloid beta-Peptides; D000975:Antioxidants; D008563:Membrane Lipids; D008670:Metals; D018696:Neuroprotective Agents; D009696:Nucleic Acids; D011506:Proteins; D017382:Reactive Oxygen Species; D011956:Receptors, Cell Surface