Influenza in three patients with human immunodeficiency virus infection.
Three Japanese outpatients with human immunodeficiency virus (HIV) infection on anti-retroviral therapy showed evidence of influenza in January 1999. CD4+ T cell counts of these patients prior to the diagnosis of influenza were 72, 248, and 152/mm3, and HIV RNA levels were 19,953, 1,259, and 1,585 copies/ml, respectively. Fever continued 4 to 5 days with no severe complications. One patient showed post-influenzal bronchitis which was effectively treated by antibiotics. None of these patients showed increased serum HIV RNA levels during and after influenza, however, in one patient, a transient reduction of CD4+ and CD8+ cells was seen during the active phase of influenza. Although symptoms of influenza in HIV carriers are generally mild and similar to those in healthy adults, careful follow-up is needed as symptoms of influenza in some HIV-infected patients can be prolonged and serious.
Nabeshima
S
S
Department of General Medicine, Kyushu University Hospital, Fukuoka.
Ariyama
I
I
Chong
Y
Y
Hirotsu
K
K
Kakuda
K
K
Hayashi
J
J
Kashiwagi
S
S
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D009980:Influenza A virus; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000209:etiology* / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D012367:RNA, Viral / Q000097:blood
D007252:Influenza Vaccines; D012367:RNA, Viral