title: Reperfusion injury significantly impacts clinical outcome after pulmonary transplantation.
abstract: BACKGROUND
  Reperfusion injury after pulmonary transplantation can contribute significantly to postoperative pulmonary dysfunction. We hypothesized that posttransplantation reperfusion injury would result in an increase in both in-hospital mortality and morbidity. We also hypothesized that the incidence of reperfusion injury would be dependent upon the cause of recipient lung disease and the interval of donor allograft ischemia.
  
  
  METHODS
  We performed a retrospective study of all lung transplant recipients at our institution from June 1990 until June 1998. One hundred patients received 120 organs during this time period. We compared two groups of patients in this study: those experiencing a significant reperfusion injury (22%) and those who did not (78%).
  
  
  RESULTS
  In-hospital mortality was significantly greater in patients experiencing reperfusion injury (40.9% versus 11.7%, p < 0.02). Posttransplantation reperfusion injury also resulted in prolonged ventilation (393.5 versus 56.8 hours, p < 0.001) and an increased length of stay in both the intensive care unit (22.2 versus 10.5 days, p < 0.01) and in the hospital (48.8 versus 25.6 days, p < 0.03). The incidence of reperfusion injury could not be attributed to length of donor organ ischemia (221.5 versus 252.9 minutes, p < 0.20). The clinical impact of reperfusion injury was significantly greater in patients undergoing transplantation for preexisting pulmonary hypertension (6/14) than those with chronic obstructive pulmonary disease or emphysema alone (6/54) (42.9% versus 11.1%, p < 0.012).
  
  
  CONCLUSIONS
  Clinically significant pulmonary reperfusion injury increased in-hospital mortality and morbidity resulting in prolonged ventilation, length of stay in the intensive care unit, and cost of hospitalization. The incidence of reperfusion injury was not dependent upon the duration of donor organ ischemia but increased with the presence of preoperative pulmonary hypertension. These findings suggest that recipient pathophysiology and donor allograft quality may play important roles in determining the incidence of reperfusion injury.
authors.affiliation: Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: King
authors.forename: O A
authors.initials: OA
authors.lastname: Binns
authors.forename: F
authors.initials: F
authors.lastname: Rodriguez
authors.forename: R C
authors.initials: RC
authors.lastname: Kanithanon
authors.forename: T M
authors.initials: TM
authors.lastname: Daniel
authors.forename: W D
authors.initials: WD
authors.lastname: Spotnitz
authors.forename: C G
authors.initials: CG
authors.lastname: Tribble
authors.forename: I L
authors.initials: IL
authors.lastname: Kron
mesh_terms: D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D017721:Hospital Costs; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay / Q000191:economics; D008168:Lung / Q000098:blood supply*; D016040:Lung Transplantation / Q000191:economics / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011183:Postoperative Complications / Q000191:economics / Q000401:mortality / Q000503:physiopathology*; D015427:Reperfusion Injury / Q000191:economics / Q000401:mortality / Q000503:physiopathology*; D012189:Retrospective Studies
chemical_list: D010100:Oxygen