Costimulation in antiviral immunity: differential requirements for CD4(+) and CD8(+) T cell responses.
A key step toward improving vaccines is understanding the molecular interactions responsible for inducing antiviral T cell responses. An emerging theme from recent studies is that CD4(+) and CD8(+) T cell responses require distinct costimulatory pathways for activation. In addition, these costimulatory interactions can play a crucial role during the death phase of the T cell response and determine the number of effector T cells that survive to become memory T cells.
Whitmire
J K
JK
Department of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA. jwhitmire@mail.liai.org
Ahmed
R
R
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*