title: Mapping of the N terminus of the Schistosoma mansoni tegumental antigen Sm15 to its predicted precursor protein.
abstract: Sm15 is a major Schistosoma mansoni 15 kDa tegumental antigen, resulting from the proteolytic processing of a larger precursor. The amino terminus of Sm15 was identified by direct amino acid sequencing, and the antigen was tentatively mapped to the segment spanning amino acids 362-497 of the precursor. This will allow subsequent studies to elucidate the possible immunological role of proteolytic processing in schistosomiasis.
authors.affiliation: Departamento de Imunologia, Cidade Universitária, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Av. Moraes Rego s/n, 50670-420, PE, Recife, Brazil.
authors.forename: R P
authors.initials: RP
authors.lastname: Werkhäuser
authors.forename: S G
authors.initials: SG
authors.lastname: De Simone
authors.forename: E
authors.initials: E
authors.lastname: Xavier
authors.forename: S M
authors.initials: SM
authors.lastname: Montenegro
authors.forename: F G
authors.initials: FG
authors.lastname: Abath
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry*; D015153:Blotting, Western; D003001:Cloning, Molecular; D016054:DNA, Protozoan / Q000737:chemistry; D018604:Epitope Mapping; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000737:chemistry*; D012550:Schistosoma mansoni / Q000737:chemistry* / Q000276:immunology; D020539:Sequence Analysis, Protein
chemical_list: D000953:Antigens, Protozoan; D016054:DNA, Protozoan; D011498:Protein Precursors