Mitochondrial DNA heteroplasmy in cloned cattle produced by fetal and adult cell cloning.
Mammals have been cloned from adult donor cells. Here we report the first cases of mitochondrial DNA (mtDNA) heteroplasmy in adult mammalian clones generated from fetal and adult donor cells. The heteroplasmic clones included a healthy cattle equivalent of the sheep Dolly, for which a lack of heteroplasmy was reported.
Steinborn
R
R
[1] Institute of Animal Breeding Genetics, University of Veterinary Medicine, Vienna, Austria. Ralf.Steinborn@vu-wien.ac.at
Schinogl
P
P
Zakhartchenko
V
V
Achmann
R
R
Schernthaner
W
W
Stojkovic
M
M
Wolf
E
E
Müller
M
M
Brem
G
G
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D019976:Cloning, Organism; D004272:DNA, Mitochondrial; D004847:Epithelial Cells / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology; D014644:Genetic Variation
D004272:DNA, Mitochondrial