title: Comparative activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against epidemiologically defined Acinetobacter baumannii strains.
abstract: In vitro activities of seven fluoroquinolones against 140 clinical Acinetobacter baumannii isolates representing 138 different strain types were determined. The rank order of activity was clinafloxacin > gatifloxacin > levofloxacin > trovafloxacin > gemifloxacin = moxifloxacin > ciprofloxacin. The 31 outbreak-related A. baumannii strains were significantly more resistant than were 109 sporadic strains.
authors.affiliation: Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Heinemann
authors.forename: H
authors.initials: H
authors.lastname: Wisplinghoff
authors.forename: M
authors.initials: M
authors.lastname: Edmond
authors.forename: H
authors.initials: H
authors.lastname: Seifert
mesh_terms: D000150:Acinetobacter / Q000187:drug effects*; D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D002939:Ciprofloxacin / Q000494:pharmacology; D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial / Q000502:physiology; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D000077735:Gemifloxacin; D005858:Germany / Q000453:epidemiology; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D011804:Quinolines
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D009287:Naphthyridines; D011804:Quinolines; D002939:Ciprofloxacin; D064704:Levofloxacin; C057477:clinafloxacin; C080163:trovafloxacin; D015242:Ofloxacin; D000077734:Gatifloxacin; D000077735:Gemifloxacin; D000077266:Moxifloxacin