Cardiac troponin I: a marker for post-burn cardiac injury.
Cardiac troponin I (cTnI) was measured by chemiluminescent immunoassay following burn injury. Thirty patients [total body surface area (TBSA) of burn 15-98%] were included in this study and each had four to six blood samples collected at 2-day intervals between the 5th and 14th days post-burn. All patients were found to have increased cTnI on two or more occasions. The mean cTnI concentration was significantly higher in patients with TBSA of burn > 30% (0.34 microg/L compared with 0.09 microg/L, P<0.001) and in those with obvious burn wound exudation (0.32 microg/L compared with 0.12 microg/L, P<0.01). cTnI concentrations peaked at the time when there was obvious burn wound exudation or spontaneous separation of eschar, then decreased after surgical excision. Two patients with persistently high cTnI concentrations developed tachycardia. We conclude that burned patients have varying degrees of non-ischaemic cardiac injury, manifesting as leakage of cTnI from myocytes into the circulation.
Chen
Y N
YN
Department of Clinical Laboratory, Guang Zhou Red Cross Hospital, P R China. stsxns@zsulink.zsu.edu.cn
Luo
Z R
ZR
Zeng
L J
LJ
Wu
M Y
MY
Wu
Y Z
YZ
Lin
Z Y
ZY
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002056:Burns; D002318:Cardiovascular Diseases / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007118:Immunoassay; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D013610:Tachycardia; D013997:Time Factors; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D019210:Troponin I