[18F]fluorodeoxyglucose positron emission tomography in the diagnosis of cancer in patients with paraneoplastic neurological syndrome and anti-Hu antibodies.
The diagnosis of cancer is often difficult in patients with paraneoplastic neurological syndrome and anti-Hu antibodies. Fluorodeoxyglucose 18 positron emission tomography scanning is a highly sensitive and specific method to detect lung tumors. We investigated 15 patients with paraneoplastic neurological syndrome and anti-Hu antibodies. Radiological methods led to the diagnosis of cancer in 12 patients, and test results were negative in 3. Whole-body [18F]fluorodeoxyglucose positron emission tomography showed abnormal uptake in the mediastinum in these 3 patients in accordance with the expected location of the malignancy.
Antoine
J C
JC
Service de Neurologie, Hôpital de Bellevue, Faculté de Médecine Jacques Lisfranc, Saint-Etienne, France.
Cinotti
L
L
Tilikete
C
C
Bouhour
F
F
Camdessanché
J P
JP
Confavreux
C
C
Vighetto
A
A
Renault-Mannel
V
V
Michel
D
D
Honnorat
J
J
D000368:Aged; D000369:Aged, 80 and over; D051959:ELAV Proteins; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000000981:diagnostic imaging* / Q000276:immunology*; D016601:RNA-Binding Proteins / Q000276:immunology*; D014055:Tomography, Emission-Computed
D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D019788:Fluorodeoxyglucose F18