title: Specific and total IgE in patients with recurrent, acute urticaria caused by Anisakis simplex.
abstract: Titres of parasite-specific IgE were investigated in 19 patients thought to have recurrent, acute urticaria caused by sensitization to Anisakis simplex (Dujardin, 1845), before and after they were placed on a fish-free diet. Patients with other allergic disease and those being treated with corticosteroids or antihistaminics were excluded. Skin-prick tests were carried out with A. simplex extract, and blue- and white-fish extracts. The CAP system (Pharmacia), a commercial test kit developed for the assay of food-specific IgE, was used to monitor serum concentrations of total IgE and antigen-specific IgE against Anisakis, Ascaris, Echinococcus, Toxocara, tuna, salmon, shrimp, mussel and cod. Before going on a fish-free diet, the 19 patients had CAP scores against A. simplex of 5 (three cases), 3 (seven) or 2 (nine). After a mean of 120 days on the diet, the scores against A. simplex were unchanged in 15 of the cases, reduced in three [from 5 to 4 (one case) or from 2 to 0 (two cases)] and increased in one (from 2 to 3). Most (16) of the patients no longer had any urticaria and the others reported significant reductions in the intensity and frequency of their symptoms.
authors.affiliation: Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Perteguer
authors.forename: T
authors.initials: T
authors.lastname: Chivato
authors.forename: A
authors.initials: A
authors.lastname: Montoro
authors.forename: C
authors.initials: C
authors.lastname: Cuéllar
authors.forename: J M
authors.initials: JM
authors.lastname: Mateos
authors.forename: R
authors.initials: R
authors.lastname: Laguna
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D017129:Anisakiasis / Q000150:complications / Q000178:diet therapy / Q000276:immunology*; D017163:Anisakis / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D005260:Female; D005399:Fishes / Q000469:parasitology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011933:Reagent Kits, Diagnostic; D012008:Recurrence; D012882:Skin Tests; D014581:Urticaria / Q000178:diet therapy / Q000209:etiology / Q000276:immunology*
chemical_list: D000947:Antigens, Helminth; D011933:Reagent Kits, Diagnostic; D007073:Immunoglobulin E