title: Synthesis of polypyrrolinones on solid support.
abstract: [reaction: see text] An efficient, three-step iterative synthesis of polypyrrolinones has been achieved on solid support, setting the stage for the construction of a wide variety of libraries based on the pyrrolinone scaffold. Central to the approach is an effective end-game sequence featuring pyrrolinone ring construction with traceless release from the solid support.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu
authors.forename: A B
authors.initials: AB
authors.lastname: Smith
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Okumura
authors.forename: D A
authors.initials: DA
authors.lastname: Favor
authors.forename: R
authors.initials: R
authors.lastname: Hirschmann
mesh_terms: D000447:Aldehydes; D006868:Hydrolysis; D007202:Indicators and Reagents; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D011760:Pyrrolidinones / Q000138:chemical synthesis*
chemical_list: D000447:Aldehydes; D007202:Indicators and Reagents; D010455:Peptides; D011760:Pyrrolidinones