Role of angiotensin-converting enzyme inhibitor, lisinopril, on spermatozoal functions in rats.
Angiotensin-converting enzyme is present in the male reproductive system but its role in the physiology of reproduction is not known. To see the effect of angiotensin-converting enzyme on spermatozoal functions, lisinopril, an angiotensin-converting enzyme inhibitor, was administered orally using two different doses (10 and 20 mg/kg/day) to rats. Both short-term (2 weeks) and long-term (6 weeks) effects of the drug were observed. Lisinopril treatment resulted in a marked decrease in sperm density, sperm motility and zona pellucida penetration. Acrosome reaction by spermatozoa obtained from drug-treated animals was significantly lower when compared with spermatozoa from normal animals.
Saha
L
L
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. med.inst@pgi.chd.nic.in
Garg
S K
SK
Bhargava
V K
VK
Mazumdar
S
S
D000177:Acrosome / Q000187:drug effects; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D017706:Lisinopril / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D015044:Zona Pellucida / Q000187:drug effects / Q000378:metabolism
D000806:Angiotensin-Converting Enzyme Inhibitors; D017706:Lisinopril; D000252:Calcium-Transporting ATPases