Cloned lines of Babesia bovis differ in their ability to induce cerebral babesiosis in cattle.
Clones of a Babesia bovis isolate known to cause particularly severe cerebral babesiosis were tested for virulence phenotype by inoculation of cattle. Clones were selected for phenotyping by two criteria - rate of growth in culture and hybridization of a virulence-related probe to Southern blots. Largely on the basis of associated mortality, B. bovis clones were judged to vary in their pathogenic potential.
Nevils
M A
MA
Department of Veterinary Patholobiology, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
Figueroa
J V
JV
Turk
J R
JR
Canto
G J
GJ
Le
V
V
Ellersieck
M R
MR
Carson
C A
CA
D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics / Q000302:isolation & purification; D016793:Babesia bovis / Q000254:growth & development / Q000302:isolation & purification* / Q000472:pathogenicity*; D001404:Babesiosis / Q000401:mortality / Q000469:parasitology*; D002196:Capillaries / Q000469:parasitology; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology*; D002469:Cell Separation; D002999:Clone Cells; D004912:Erythrocytes / Q000469:parasitology; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008297:Male; D010641:Phenotype; D015800:Protozoan Proteins / Q000235:genetics / Q000302:isolation & purification; D013154:Spleen / Q000469:parasitology / Q000473:pathology; D013687:Telencephalon / Q000098:blood supply / Q000469:parasitology* / Q000473:pathology
D000953:Antigens, Protozoan; D015800:Protozoan Proteins