title: Collagen metabolism markers as a reflection of bone and soft tissue turnover during the menstrual cycle and oral contraceptive use.
abstract: Two different groups of women, 23 healthy young adults and 13 women with chronic posterior pelvic pain, were studied before and during use of oral contraceptives (OC). Collagen metabolism markers-here, the amino-terminal propeptide of type I procollagen, the carboxy-terminal telopeptide of type I collagen, and the amino-terminal of procollagen type III-as well as hormones and other endocrine factors indicating the balance between androgen expression/anabolism and catabolism of the subjects (testosterone, sex-hormone binding globulin, and insulin-like growth factor I were measured. Type I procollagen, the carboxy-terminal telopeptide of type I collagen, and the amino-terminal of procollagen type III were all significantly decreased during OC use. These findings implicate OC use-induced changes in collagen type I and III turnover. A shift in the anabolic/catabolic balance was also recorded indicating a less anabolic situation during OC use.
authors.affiliation: Department of Clinical Sciences, Division of Family Medicine, Stockholm, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Wreje
authors.forename: J
authors.initials: J
authors.lastname: Brynhildsen
authors.forename: H
authors.initials: H
authors.lastname: Aberg
authors.forename: B
authors.initials: B
authors.lastname: Byström
authors.forename: M
authors.initials: M
authors.lastname: Hammar
authors.forename: B
authors.initials: B
authors.lastname: von Schoultz
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D016723:Bone Remodeling; D003094:Collagen / Q000097:blood / Q000378:metabolism*; D024042:Collagen Type I; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008597:Menstrual Cycle; D017699:Pelvic Pain; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D011347:Procollagen / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D003276:Contraceptives, Oral; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; D012738:Sex Hormone-Binding Globulin; C052929:collagen type I trimeric cross-linked peptide; C041876:procollagen Type III-N-terminal peptide; D007334:Insulin-Like Growth Factor I; D003094:Collagen