Effect of Helicobacter pylori eradication on malignant transformation of gastric adenoma.
BACKGROUND
A nonrandomized trial of Helicobacter pylori eradication was conducted in patients with endoscopically diagnosed gastric adenoma to determine the long-term effect of antimicrobial treatment on progression of the adenoma.


METHODS
Of 64 patients with an endoscopically diagnosed gastric adenoma and H pylori infection, 32 were treated with omeprazole and antibiotics to eradicate the infection, and 32 were not.


RESULTS
During 2 years of follow-up, 4 (12.5%) of the 32 patients in the untreated group developed an early stage, intestinal-type gastric cancer, whereas no gastric cancer was found in the 32 patients in the treated group.


CONCLUSIONS
H Pylori eradication may inhibit progression of gastric adenoma to carcinoma.
Saito
K
K
First Department of Internal Medicine, Gunma University School of Medicine, Japan.
Arai
K
K
Mori
M
M
Kobayashi
R
R
Ohki
I
I
D000236:Adenoma / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000008:administration & dosage*; D002277:Carcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D017291:Clarithromycin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage*; D011336:Probability; D012016:Reference Values; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D016896:Treatment Outcome
D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole