Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method.
Solid-phase synthetic method of muramyl dipeptide derivatives is reported. A diverse library of muramyl dipeptides could be potentially synthesized by acylation, reductive alkylation, sulfonamide formation, urea formation, N-alkylation, amine addition, or component Ugi reactions based on this method for drug screening.
Liu
G
G
Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing, China. gangliu27@yahoo.com
Zhang
S D
SD
Xia
S Q
SQ
Ding
Z K
ZK
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000138:chemical synthesis / Q000737:chemistry*; D000215:Acylation; D000478:Alkylation; D013449:Sulfonamides / Q000737:chemistry; D014508:Urea / Q000737:chemistry
D013449:Sulfonamides; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D014508:Urea