title: Antiplasmodial, analgesic, and anti-inflammatory activities of the aqueous extract of the stem bark of Erythrina senegalensis.
abstract: The in vivo antiplasmodial, analgesic and anti-inflammatory properties of Erythrina senegalensis, an ornamental plant commonly used in Northern Nigeria for the treatment of fevers, was evaluated. Aqueous extracts of the stem bark of the plant was used for the study. The in vivo antiplasmodial activity of the aqueous extract against Plasmodium berghei was assessed using the suppressive and curative test procedures. Analgesic activity was assessed using the acetic acid (0.75%v/v) induced abdominal constriction, while the anti-inflammatory activity was evaluated on egg-albumin induced paw oedema in rats as a model of acute inflammation. The stem bark extract of E. senegalensis exhibited only slight antiplasmodial activity while significant (P<0.05) analgesic and anti-inflammatory effects were observed. Preliminary phytochemical analysis of the extract indicates the presence of alkaloids and glycosides.
authors.affiliation: Department of Pharmacology & Toxicology, National Institute for Pharmaceutical Research and Development, P.M.B. 21, Abuja, Nigeria.
authors.forename: K
authors.initials: K
authors.lastname: Saidu
authors.forename: J
authors.initials: J
authors.lastname: Onah
authors.forename: A
authors.initials: A
authors.lastname: Orisadipe
authors.forename: A
authors.initials: A
authors.lastname: Olusola
authors.forename: C
authors.initials: C
authors.lastname: Wambebe
authors.forename: K
authors.initials: K
authors.lastname: Gamaniel
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D051379:Mice; D009549:Nigeria; D010147:Pain Measurement / Q000187:drug effects; D019441:Plant Epidermis / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010962:Plasmodium berghei / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000962:Antimalarials; D010936:Plant Extracts