title: Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa.
abstract: Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 micrograms/mL respectively.
authors.forename: C C
authors.initials: CC
authors.lastname: Neto
authors.forename: A J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: B N
authors.initials: BN
authors.lastname: Zhou
authors.forename: D G
authors.initials: DG
authors.lastname: Kingston
authors.forename: G B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010568:Peru; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D000097245:Ursolic Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009828:Oleanolic Acid; D014315:Triterpenes; D000097245:Ursolic Acid; C412808:2-oxopomolic acid; C412807:3-O-acetylpomolic acid; C115535:pomolic acid