title: Regional differences in metronidazole resistance and increasing clarithromycin resistance among Helicobacter pylori isolates from Japan.
abstract: The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions in Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and 12.9%, respectively. While there was no difference in clarithromycin resistance, the prevalence of metronidazole resistance was significantly higher in Kyoto (23.8%) than in Sapporo (8.1%). From 1996 to 1999, the prevalence of metronidazole resistance did not change but the prevalence of clarithromycin resistance doubled (from 9.1 to 18.7%).
authors.affiliation: Department of Endoscopy, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: J J
authors.initials: JJ
authors.lastname: Kim
authors.forename: R
authors.initials: R
authors.lastname: Reddy
authors.forename: M
authors.initials: M
authors.lastname: Asaka
authors.forename: K
authors.initials: K
authors.lastname: Kashima
authors.forename: M S
authors.initials: MS
authors.lastname: Osato
authors.forename: F A
authors.initials: FA
authors.lastname: El-Zaatari
authors.forename: D Y
authors.initials: DY
authors.lastname: Graham
authors.forename: D H
authors.initials: DH
authors.lastname: Kwon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005260:Female; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D017291:Clarithromycin