title: Protracted febrile myalgia of familial Mediterranean fever. Mutation analysis and clinical correlations.
abstract: Protracted febrile myalgia (PFM) is a rare form of vasculitic disease that affects patients with familial Mediterranean fever (FMF). Mutation analysis performed in 15 patients who suffered from this disorder showed that 9 of the 15 patients were homozygous for M694V. FMF in these 9 patients was associated with more severe symptoms compared to a group of 30 M694V homozygous FMF patients without PFM.
authors.affiliation: Department of Medicine C, Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Sidi
authors.forename: Y
authors.initials: Y
authors.lastname: Shinar
authors.forename: A
authors.initials: A
authors.lastname: Livneh
authors.forename: P
authors.initials: P
authors.lastname: Langevitz
authors.forename: M
authors.initials: M
authors.lastname: Pras
authors.forename: E
authors.initials: E
authors.lastname: Pras
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003598:Cytoskeletal Proteins; D004252:DNA Mutational Analysis; D010505:Familial Mediterranean Fever / Q000235:genetics*; D005260:Female; D005334:Fever / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009135:Muscular Diseases / Q000235:genetics*; D009154:Mutation; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D000071198:Pyrin
chemical_list: D003598:Cytoskeletal Proteins; C000604192:MEFV protein, human; D011506:Proteins; D000071198:Pyrin