[Fatal anaphylactic reaction after oral acetazolamide (diamox) for glaucoma].
A woman aged 66 was prescribed acetazolamide (Diamox) in the outpatient clinic because of glaucoma. She went into irreversible anaphylactic shock with massive pulmonary oedema, probably due to a cross reaction in sulphonamide allergy. Before prescribing acetazolamide, the physician should inquire about sulphonamide allergy because of the related chemical structure of the substances. Such an allergy should be regarded as a contraindication.
Gerhards
L J
LJ
Afd. Cardiologie, Martini Ziekenhuis, Groningen.
van Arnhem
A C
AC
Holman
N D
ND
Nossent
G D
GD
D000086:Acetazolamide / Q000009:adverse effects* / Q000494:pharmacology; D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced*; D000075202:Contraindications; D004232:Diuretics / Q000009:adverse effects* / Q000494:pharmacology; D004342:Drug Hypersensitivity / Q000150:complications; D004347:Drug Interactions; D017809:Fatal Outcome; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D011654:Pulmonary Edema / Q000139:chemically induced; D013449:Sulfonamides / Q000009:adverse effects
D004232:Diuretics; D013449:Sulfonamides; D000086:Acetazolamide