title: Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2).
abstract: A case of extraskeletal myxoid chondrosarcoma (EMC) in which there was histochemical, immunohistochemical, and ultrastructural evidence of neuroendocrine differentiation is reported. Genetic investigations showed the recently described novel translocation t(9;17)(q22;q11.2) and associated fusion of the CHN and RBP56 genes, contrasting with the translocation t(9;22)(q22;q12) and EWS/CHN gene fusion found in the majority of EMCs.
authors.affiliation: Department of Histopathology, Christie Hospital, Manchester, UK.
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: J
authors.initials: J
authors.lastname: Coyne
authors.forename: M
authors.initials: M
authors.lastname: Tariq
authors.forename: B P
authors.initials: BP
authors.lastname: Eyden
authors.forename: M
authors.initials: M
authors.lastname: Atkinson
authors.forename: A J
authors.initials: AJ
authors.lastname: Freemont
authors.forename: J
authors.initials: J
authors.lastname: Varley
authors.forename: C
authors.initials: C
authors.lastname: Attwooll
authors.forename: N
authors.initials: N
authors.lastname: Telford
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002081:Buttocks; D002454:Cell Differentiation; D002813:Chondrosarcoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003582:Cytogenetics; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000378:metabolism / Q000473:pathology*; D011347:Procollagen / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000235:genetics; D016622:Silver Staining; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D011347:Procollagen; D012333:RNA, Messenger; D012334:RNA, Neoplasm