[The effect of estradiol on human endometrial cancer. Experimental in vivo and in vitro studies].
In this article our findings concerning estradiol-induced changes in steroid receptor activation, cell kinetics and tumor growth regulation during in vivo and in vitro progression of human endometrial adenocarcinomas are reviewed. We found major changes such as alterations in estrogen receptor function and post-receptor alterations in tumor growth regulation. Our results suggest that although the development of these alterations is genetically determined, they may to some extent be modified by circulating estradiol levels. No biological changes were found, suggesting that the use of menopausal estrogen replacement therapy by women with non-diagnosed endometrial cancer may increase their death rate.
Horvath
G
G
Sektionen för gynekologisk onkologi, Sahlgrenska Universitetssjukhuset, Göteborg. gyorgy.horvath@sahlgrenska.se
D000230:Adenocarcinoma / Q000139:chemically induced / Q000235:genetics / Q000473:pathology*; D000818:Animals; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D016889:Endometrial Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000473:pathology*; D004958:Estradiol / Q000008:administration & dosage* / Q000009:adverse effects; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D051379:Mice; D011960:Receptors, Estrogen / Q000187:drug effects; D012307:Risk Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects
D011960:Receptors, Estrogen; D004958:Estradiol