title: Lack of association between TTV viral load and aminotransferase levels in patients with hepatitis C or non-B-C.
abstract: TT virus (TTV) is a newly identified un-enveloped single-stranded DNA virus. Although TTV was initially thought to be a new hepatitis virus, it is still unclear whether it causes hepatitis. To clarify the natural history and pathogenesis of TTV infection, serial serum samples from patients with chronic hepatitis were analysed. TTV DNA was quantified by real-time detection polymerase chain reaction assay (RTD-PCR), which was adapted for TTV. Five patients with chronic hepatitis, 4 with hepatitis C and 1 with non-B-C, were studied. The study period ranged from 9 to 50 months. In 3 patients there were frequent increases in TTV DNA titres, but no concomitant elevation of the aminotransferase (ALT) levels. In 2 patients who were treated with interferon, the changes in TTV titres were not synchronized with those of the ALT levels. Thus, in cases of chronic hepatitis, no correlation was observed between the serum TTV DNA titres and the ALT levels.
authors.affiliation: Second Department of Medicine, Nagoya City University Medical School, Mizuho, Nagoya, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Mizokami
authors.forename: E
authors.initials: E
authors.lastname: Orito
authors.forename: T
authors.initials: T
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: F
authors.initials: F
authors.lastname: Sugauchi
authors.forename: M
authors.initials: M
authors.lastname: Mukaide
authors.forename: R
authors.initials: R
authors.lastname: Ueda
mesh_terms: D000328:Adult; D004266:DNA Virus Infections / Q000175:diagnosis* / Q000503:physiopathology; D004267:DNA Viruses / Q000302:isolation & purification*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000201:enzymology / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000201:enzymology* / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D000637:Transaminases / Q000097:blood*; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D000637:Transaminases