title: Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors.
abstract: Following the identification of first pass metabolism issues with our recently described anti-HCMV compounds, the naphthyridines and isoquinolines, we have designed a class of novel metabolically stable and orally bioavailable anti-HCMV agents, the dihydroisoquinolines.
authors.affiliation: BioChem Pharma Inc., Laval, Québec, Canada. chanl@biochempharma.com
authors.forename: L
authors.initials: L
authors.lastname: Chan
authors.forename: T
authors.initials: T
authors.lastname: Stefanac
authors.forename: N
authors.initials: N
authors.lastname: Turcotte
authors.forename: Z
authors.initials: Z
authors.lastname: Hu
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Bédard
authors.forename: S
authors.initials: S
authors.lastname: May
authors.forename: H
authors.initials: H
authors.lastname: Jin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects*; D015195:Drug Design; D006801:Humans; D007546:Isoquinolines / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D009287:Naphthyridines / Q000737:chemistry; D010627:Phenethylamines / Q000737:chemistry; D010948:Viral Plaque Assay
chemical_list: D000998:Antiviral Agents; D007546:Isoquinolines; D009287:Naphthyridines; D010627:Phenethylamines