New 1,3-benzoxazin-2-ones or thiones of molluscacidal activity.
A facile synthetic approach towards 3-aryl, alkyl or beta-glucopyranosyl-1,3-benzoxazin-2-ones and their thio-analogues 3 was adopted via the reaction of the easily available 3-(2-hydroxyaryl)-2-propen-1-ones 1 with a variety of isocyanates or isothiocyanates. The isolation of the open-chain carbamates 2 and then independent cyclization to the corresponding 1,3-benzoxazines 3 confirms the reaction sequence. Molluscacidal activity of the products was screened.
Girgis
A S
AS
National Research Centre, Dokki, Cairo, Egypt.
D000818:Animals; D001700:Biomphalaria / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D008975:Molluscacides / Q000138:chemical synthesis* / Q000494:pharmacology; D010078:Oxazines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D008975:Molluscacides; D010078:Oxazines