title: Brain abscess formation in radiation necrosis of the temporal lobe following radiation therapy for nasopharyngeal carcinoma.
abstract: BACKGROUND
  Radiation necrosis is a known complication following radiation therapy for extracranial as well as intracranial tumours. However, brain abscess formation in radiation necrosis has not been reported in the literature. We report the clinical data of 6 patients suffering from this condition.
  
  
  METHODS
  Twenty-eight patients with radiation necrosis of the temporal lobe following radiotherapy for nasopharyngeal carcinoma were treated surgically at the Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong between January 1992 and July 1999. Of these, 6 cases were complicated by brain abscess formation. The clinical data of these 6 patients are retrospectively reviewed.
  
  
  RESULTS
  The patients were 5 males and 1 female, ranging in age from 41 to 67 years. Three patients had previous treatment with steroids for the symptomatic radiation necrosis. A history of nasal infection or otitis media was recognised in all 6 patients. All patients were treated surgically by temporal lobectomy and excision of the necrotic tissue together with the abscess cavity. Intra-operatively, a bony defect was observed between the middle cranial fossa and the sphenoid sinus in 3 patients and the bony defect was repaired with a temporalis muscle flap. The species of organisms could only be identified in 3 patients. In 3 patients, the pus smear was positive but the culture was negative. Subsequently, 4 patients recovered and 2 patients died.
  
  
  CONCLUSIONS
  Cerebral radiation necrosis is a predisposing cause of brain abscess formation. Surgical excision is recommended as the treatment of choice in this group of patients.
authors.affiliation: Department of Neurosurgery, Queen Elizabeth Hospital, Hong Kong, China.
authors.forename: K M
authors.initials: KM
authors.lastname: Cheng
authors.forename: C M
authors.initials: CM
authors.lastname: Chan
authors.forename: Y T
authors.initials: YT
authors.lastname: Fu
authors.forename: L C
authors.initials: LC
authors.lastname: Ho
authors.forename: Y W
authors.initials: YW
authors.lastname: Tsang
authors.forename: M K
authors.initials: MK
authors.lastname: Lee
authors.forename: Y L
authors.initials: YL
authors.lastname: Cheung
authors.forename: C K
authors.initials: CK
authors.lastname: Law
mesh_terms: D000328:Adult; D000368:Aged; D001922:Brain Abscess / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D002277:Carcinoma / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D009336:Necrosis; D011832:Radiation Injuries / Q000150:complications* / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology / Q000528:radiation effects*; D014057:Tomography, X-Ray Computed