title: A convenient synthesis of a novel nucleoside analogue: 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone.
abstract: The nucleoside analogue 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone (5) was prepared from the corresponding 4-methyl pyrimidinone nucleoside by means of the Vilsmeier reaction. The unprotected nucleoside can be phosphorylated directly with phosphorus oxychloride in triethyl phosphate.
authors.affiliation: Salk Institute for Biological Studies, La Jolla, California 92037, USA.
authors.forename: K
authors.initials: K
authors.lastname: Gao
authors.forename: L E
authors.initials: LE
authors.lastname: Orgel
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003562:Cytidine / Q000138:chemical synthesis*; D005663:Furans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*
chemical_list: C414832:4-(diformyl-methyl)-1-(ribofuranosyl)-2-pyrimidinone; D005663:Furans; D011741:Pyrimidine Nucleosides; D003562:Cytidine