title: Life-threatening status asthmaticus treated with inhaled nitric oxide.
abstract: Inhaled nitric oxide (NO) was administered to 5 consecutive children with life-threatening status asthmaticus who required mechanical ventilation and did not respond to maximal medical management. Four showed a >20% decrease in baseline PaCO(2) (median PaCO(2) = 154 mm Hg, range = 95 to 229 mm Hg) occurring rapidly after the administration of inhaled NO. Three children, in addition to the index case, received continuous inhaled NO therapy, ranging from 5.5 to 21.5 hours. Systemic hypotension was not observed, and the maximum methemoglobin level was 1.9%. Four children survived to hospital discharge. Although the precise mechanism of action is not known, it appears that inhaled NO merits further study and may represent a life-saving therapy in this select patient population.
authors.affiliation: Department of Pediatrics, Children's Hospital of The King's Daughters, EasternVirginia Medical School, Norfolk 23507, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Nakagawa
authors.forename: S J
authors.initials: SJ
authors.lastname: Johnston
authors.forename: S A
authors.initials: SA
authors.lastname: Falkos
authors.forename: R J
authors.initials: RJ
authors.lastname: Gomez
authors.forename: A
authors.initials: A
authors.lastname: Morris
mesh_terms: D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000627:therapeutic use*; D012121:Respiration, Artificial; D013224:Status Asthmaticus / Q000188:drug therapy* / Q000628:therapy
chemical_list: D001993:Bronchodilator Agents; D002245:Carbon Dioxide; D009569:Nitric Oxide