title: A new allele, HLA-B*1555, identified in an African patient awaiting bone marrow transplantation.
abstract: Human HLA genes exhibit extreme polymorphism, the extent of which is emphasised by the identification of an ever increasing number of new alleles by DNA-based typing strategies. Here we describe a novel allele, belonging to the HLA-B*15 group, which was identified in an African patient awaiting a bone marrow transplant This individual was shown to exhibit two HLA-B alleles, B*5301 and a new allele which has been named B*1555. B*1555 differs from B*1531 in exon 3 by a single nucleotide substitution. This substitution results in a change in the amino acid residue at position 97, which is located within the beta-pleated sheet region of the HLA molecule.
authors.affiliation: Anthony Nolan Research Institute and Histocompatiblity Laboratories, The Royal Free Hospital, Hampstead, London, United Kingdom.
authors.forename: M A
authors.initials: MA
authors.lastname: Hoddinott
authors.forename: S T
authors.initials: ST
authors.lastname: Cox
authors.forename: A J
authors.initials: AJ
authors.lastname: McWhinnie
authors.forename: S G
authors.initials: SG
authors.lastname: Marsh
authors.forename: H
authors.initials: H
authors.lastname: Ogilvie
authors.forename: J A
authors.initials: JA
authors.lastname: Madrigal
authors.forename: A M
authors.initials: AM
authors.lastname: Little
mesh_terms: D000349:Africa / Q000208:ethnology; D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001483:Base Sequence; D044383:Black People / Q000235:genetics*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005091:Exons; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D006113:United Kingdom
chemical_list: D015235:HLA-B Antigens