Contact allergy to 5,5'-di-tert-butyl-2,2'-dihydroxy-(hydroxymethyl)-dibenzyl ethers, sensitizers, in p-tert-butylphenol-formaldehyde resin.
Allergy to p-tert-butylphenol-formaldehyde resin (PTBP-F-R) is not rare. This resin consists of a large number of substances, most of which are still unknown. More knowledge about the sensitizers in the resin is a good basis for development of diagnosis, treatment and prevention. The aim of this investigation was to study allergens in PTBP-F-R by isolation of some medium molecular weight substances from the resin and patch testing these in individuals hypersensitive to PTBP-F-R. 2 isolated substances were shown to be allergens in PTBP-F-R, 5,5'-di-tert-butyl-2,2'-dihydroxy-3,3'-dihydroxymethyl-dibenzyl ether and 5,5'-di-tert-butyl-2,2'-dihydroxy-3-hydroxymethyl-dibenzyl ether. 13 patients hypersensitive to PTBP-F-R were patch tested with serial dilutions of 5,5'-di-tert-butyl-2,2'-dihydroxy-3,3'-dihydroxymethyl-dibenzyl ether and 12 of them reacted positively. 12 patients hypersensitive to PTBP-F-R were patch tested with serial dilutions of 5,5'-di-tert-butyl-2,2'-dihydroxy-3-hydroxymethyl-dibenzyl ether and 11 of them reacted positively. Positive patch test reactions were seen down to 0.0000025 mmole x 1(-1) (approximately 0.01 ppm) for both 5,5'-di-tert-butyl-2,2'-dihydroxy-3,3'-dihydroxymethyl-dibenzyl ether and 5,5'-di-tert-butyl-2,2'-dihydroxy-3-hydroxymethyl-dibenzyl ether in the most sensitive patient. HPLC analysis of 2 PTBP-F-Rs showed the presence of 1.0-1.7% w/w 5,5'-di-tert-butyl-2,2'-dihydroxy-3,3'-dihydroxymethyl-dibenzyl ether and 0.75-0.90% w/w 5,5'-di-tert-butyl-2,2'-dihydroxy-3-hydroxymethyl-dibenzyl ether in the resins.
Zimerson
E
E
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Sweden.
Bruze
M
M
D000485:Allergens / Q000009:adverse effects* / Q000737:chemistry; D001593:Benzyl Compounds / Q000009:adverse effects / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D004987:Ethers / Q000009:adverse effects / Q000737:chemistry*; D006801:Humans; D010328:Patch Tests; D012117:Resins, Synthetic / Q000009:adverse effects* / Q000737:chemistry*
C417688:5,5'-di-tert-butyl-2,2'-dihydroxy-3,3'-dihydroxymethyl dibenzyl ether; D000485:Allergens; D001593:Benzyl Compounds; D004987:Ethers; D012117:Resins, Synthetic; C014273:p-tert-butylphenolformaldehyde resin; C417689:5,5'-di-tert-butyl-2,2'-dihydroxy-3-hydroxymethyl dibenzyl ether