Cloning genes for non-syndromal hearing impairment.
Over 45 genes that cause autosomal non-syndromic hearing impairment (NSHI) have been localized and many more are predicted to exist. To clone these genes, a number of different strategies can be used. This paper focuses on four general approaches: functional cloning, positional cloning, position-dependent candidate gene cloning, and position-independent candidate gene cloning.
Smith
R J
RJ
Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City 52242, USA. richard-smith@uiowa.edu
Van Camp
G
G
D019976:Cloning, Organism / Q000379:methods*; D015870:Gene Expression / Q000235:genetics*; D006311:Hearing Disorders / Q000235:genetics*; D006801:Humans; D017354:Point Mutation / Q000235:genetics; D009626:Terminology as Topic