title: [Hyponatremia--with comments on hypernatremia].
abstract: Disorders of the serum sodium concentration (hypo- and hypernatremia) are amongst the most frequent electrolyte disorders in clinical medicine. They are attributable to disturbance of to water metabolism. Hyponatremia is almost always a condition of water excess while hypernatremia is due water deficiency. Physiological normonatremia (normal plasma osmolality) is maintained by an integrated system involving regulated water intake via thirst and control of water excretion via antidiuretic hormone secretion. Therefore hypo- and hypernatremia should be analyzed in terms of dysregulated ADH secretion, fluid intake and renal water excretion. Hyponatremia is usually a disorder of vasopressin excess, due to 'non-osmotic' vasopressin release. The latter may occur in two different settings: (I) SIADH, (II) baroreceptor mediated vasopressin secretion (cardiac failure, liver cirrhosis). This entities are easy to distinguish in clinical practice. SIADH is associated with striking lower plasma concentrations of urate, creatinine and urea. In SIADH the blood pressure is normal and there is no edema. In contrast in the hyponatremia of liver cirrhosis and heart failure the plasma measurements indicated are usually slightly elevated, the blood pressure is low and there is edema. The typical patient with hypernatremia is old and has no thirst sensation. Hypo- or hypernatremia may cause major neurologic symptoms. These symptoms are more related to the rate of change in the serum sodium concentration than to the absolute level of a hypo- or hypernatremia reached. The traditional treatment for hyponatremia used to be water restriction. However V2-Vasopressin-Antagonists may provide a better treatment modality in the future. Hypernatremia is treated by slow rehydratation.
authors.affiliation: Medizinische Klinik III, Universitätsklinikum Dresden, Deutschland.
authors.forename: C
authors.initials: C
authors.lastname: Palm
authors.forename: D
authors.initials: D
authors.lastname: Reimann
authors.forename: P
authors.initials: P
authors.lastname: Gross
mesh_terms: D003937:Diagnosis, Differential; D004326:Drinking; D005440:Fluid Therapy; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis; D006801:Humans; D006955:Hypernatremia / Q000097:blood / Q000209:etiology* / Q000628:therapy; D007010:Hyponatremia / Q000097:blood / Q000209:etiology* / Q000628:therapy; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis; D014667:Vasopressins / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D014667:Vasopressins