title: In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans.
abstract: The antifungal activity of nyasol (NYS) alone or with various antifungal agents was measured in vitro against Candida albicans, Aspergillus fumigatus, and Trichophyton mentagrophytes. NYS is a compound recently purified from a medicinal plant, Anemarrhena asphodeloides. Among 12 agents, miconazole (MCZ), ketoconazole (KCZ), clotrimazole (CTZ), and cerulenin showed marked synergistic effects against C. albicans. The fractional inhibition concentration (FIC) indices against 4 strains of C. albicans were 0.067-0.31 for MCZ plus NYS, 0.078-0.31 for KCZ plus NYS, and 0.098-0.13 for CTZ plus NYS. These values indicate the possibility of using NYS as an adjuvant to azole agents in the chemotherapy of candidiasis.
authors.affiliation: Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iida
authors.forename: K B
authors.initials: KB
authors.lastname: Oh
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Matsuoka
authors.forename: H
authors.initials: H
authors.lastname: Kurata
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D001393:Azoles / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004357:Drug Synergism; D005658:Fungi / Q000187:drug effects*; D017705:Lignans; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014249:Trichophyton / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D017705:Lignans; D010636:Phenols; C109393:nyasol