title: Comparison of maritime pine oil and fish oil effects on plasma lipoproteins in apolipoprotein E-deficient mice.
abstract: The goal of this study was to compare the lipid lowering properties of maritime pine and fish oils in apolipoprotein E-deficient (KOE) mice, an animal model of hyperlipidemia. KOE mice were supplemented with either lard, fish or maritime pine oil (10% w/w) for one month. Compared to lard, fish and maritime pine oils decreased cholesterol (-31% and -52% respectively) and phospholipid (-41 and -52%) levels and increased triglyceride (+182% and +123%) levels. These lipid changes resulted in an enrichment in triglycerides and a depletion in cholesterol of VLDL+IDL plasma fraction as compared to lard-fed mice. These findings suggest that VLDL-triglyceride lipolysis is impaired in KOE mice fed fish or maritime pine oil.
authors.affiliation: 1INSERM U-325, Lille, France.
authors.forename: G
authors.initials: G
authors.lastname: Asset
authors.forename: E
authors.initials: E
authors.lastname: Baugé
authors.forename: R L
authors.initials: RL
authors.lastname: Wolff
authors.forename: J C
authors.initials: JC
authors.lastname: Fruchart
authors.forename: J
authors.initials: J
authors.lastname: Dallongeville
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency*; D002784:Cholesterol / Q000097:blood; D002850:Chromatography, Gel; D004041:Dietary Fats / Q000494:pharmacology; D004195:Disease Models, Animal; D005395:Fish Oils / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000097:blood; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000737:chemistry / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry; D008079:Lipoproteins, VLDL / Q000097:blood / Q000737:chemistry; D008297:Male; D008386:Marine Biology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010743:Phospholipids / Q000097:blood; D010938:Plant Oils / Q000494:pharmacology*; D014197:Trees
chemical_list: D001057:Apolipoproteins E; D004041:Dietary Fats; D005395:Fish Oils; D008055:Lipids; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010743:Phospholipids; D010938:Plant Oils; D002784:Cholesterol; C029310:lard