Helicobacter pylori may have only a transient presence in the oral cavity and on the surface of oral cancer.
We used the reverse transcription polymerase chain reaction (RT-PCR) and culture methods to study the presence of Helicobacter pylori in the gastric and oral samples from a total of 116 gastritis and peptic ulcer patients, including 58 with oral cancer. Detection rates of H. pylori were 46.6% in stomach samples and 12.1% in oral swab samples. All of the oral cancer surface swab samples were positive for H. pylori, as were their gastric samples suggesting that oral H. pylori derived from the stomach. The culture supernatants of Streptococcus mutans and Prevotella intermedia inhibited the growth of the H. pylori strain and caused the formation of the coccal form. In cases where H. pylori was detected in the oral cavity samples, including the oral cancer surface samples, it was believed that this species had colonized the stomach and were present in the oral cavity only as a transient organism.
Okuda
K
K
Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan. kokuda@tdc.ac.jp
Ishihara
K
K
Miura
T
T
Katakura
A
A
Noma
H
H
Ebihara
Y
Y
D001426:Bacterial Proteins / Q000737:chemistry / Q000494:pharmacology; D001685:Biological Factors / Q000737:chemistry / Q000494:pharmacology; D015169:Colony Count, Microbial; D005756:Gastritis / Q000382:microbiology; D016480:Helicobacter pylori / Q000254:growth & development* / Q000302:isolation & purification; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D009062:Mouth Neoplasms / Q000382:microbiology*; D010437:Peptic Ulcer / Q000382:microbiology; D018713:Prevotella intermedia / Q000737:chemistry; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013270:Stomach / Q000382:microbiology; D013295:Streptococcus mutans / Q000737:chemistry
D001426:Bacterial Proteins; D001685:Biological Factors