Interleukin-10 has different effects on proliferation of Listeria monocytogenes in livers and spleens of mice.
The aim of this study was to investigate the effect of interleukin-10 (IL-10) on the course of Listeria monocytogenes infection in naive and immune mice. Treatment with IL-10 during the course of a primary infection significantly decreased the number of bacteria in the spleen and did not affect the number in the liver. During a secondary infection in immune mice treated with IL-10, the number of bacteria was significantly lower in the spleen but significantly higher in the liver in comparison to mock-treated immune mice. IL-10 treatment during a primary Listeria infection decreased the concentration of gamma interferon (IFN-gamma) in plasma and the toxoplasmastatic activity of macrophages, whereas it increased the percentage of mildly CD3-positive T cells in the spleen. During a secondary infection, the concentration of IFN-gamma in plasma was decreased on day 1 but remained unaffected during later days of infection. From these results, we conclude that IL-10 has different effects on the proliferation of L. monocytogenes in the spleen and liver during primary and secondary Listeria infections.
Samsom
J N
JN
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. jn.samsom.cell@med.vu.nl
Annema
A
A
Geertsma
M F
MF
Langermans
J A
JA
Groeneveld
P H
PH
de Heer
E
E
van Furth
R
R
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D017252:CD3 Complex / Q000032:analysis; D002455:Cell Division / Q000187:drug effects; D005260:Female; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000276:immunology* / Q000627:therapeutic use; D008088:Listeriosis / Q000188:drug therapy / Q000276:immunology*; D008099:Liver / Q000166:cytology / Q000382:microbiology*; D008262:Macrophage Activation; D051379:Mice; D008808:Mice, Inbred CBA; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013154:Spleen / Q000166:cytology / Q000382:microbiology*; D016176:T-Lymphocyte Subsets; D018417:Th1 Cells
D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016753:Interleukin-10; D007371:Interferon-gamma