title: Aldehyde dehydrogenase 2 and glutathione S-transferase M 1 polymorphisms in relation to the risk for oral cancer in Japanese drinkers.
abstract: We investigated 191 patients with oral cancer (121 males and 70 females) and 121 non oral cancer patients (69 males and 52 females), both groups with a history of alcohol use. Blood was analyzed with aldehyde dehydrogenase 2 (ALDH 2) and glutathione S-transferase M 1 (GSTM 1) genotyping. ALDH 2 genotyping was performed by polymerase chain reaction (PCR)-Restriction fragment length polymorphism (RFLP) method and GSTM 1 genotyping was amplified with PCR using GSTM 1 specific primers. In the oral cancer group, the alcohol-drinking rate (59.7%) was significantly higher than in the non cancer group (alcohol-drinking rate 27.3%, p < 0.01). The incidence of inactive ALDH 2 and GSTM 1 in the cancer group with an alcohol-drinking habit was 34.2 and 67.5% and was higher than in the non cancer group with an alcohol-drinking habit (15.1, 45.5%).
authors.affiliation: First Department of Oral and Maxillofacial Surgery, Tokyo Dental College, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: H
authors.initials: H
authors.lastname: Noma
authors.forename: T
authors.initials: T
authors.lastname: Shibahara
authors.forename: A
authors.initials: A
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Muramatusu
authors.forename: T
authors.initials: T
authors.lastname: Ohmori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects; D000444:Aldehyde Dehydrogenase / Q000097:blood* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005982:Glutathione Transferase / Q000097:blood* / Q000235:genetics; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics; D009363:Neoplasm Proteins / Q000097:blood* / Q000235:genetics; D016017:Odds Ratio; D012307:Risk Factors
chemical_list: D009363:Neoplasm Proteins; D000444:Aldehyde Dehydrogenase; D005982:Glutathione Transferase