title: High incidence of respiratory distress syndrome (RDS) in infants born to mothers with placenta previa.
abstract: OBJECTIVE
  To evaluate the incidence of respiratory distress syndrome (RDS) in infants born to mothers with placenta previa and to assess the risk factors for RDS.
  
  
  METHODS
  Ninety-nine pregnant women with placenta previa who delivered by cesarean section at 30-35 weeks of gestation were compared retrospectively with 102 pregnant women matched for week of gestation and birth year, who underwent elective cesarean section. Maternal characteristics, neonatal outcome, and incidence of RDS were analyzed. Umbilical cord blood samples were collected at delivery and were used to determine cortisol, epinephrine, and norepinephrine levels. Student's t-test, the chi-square test, and Fisher's exact test were used for statistical comparisons. P < 0.05 was considered significant. The Mann-Whitney U test was used for comparison of continuous variables.
  
  
  RESULTS
  Preeclampsia, histological chorioamnionitis, and premature rupture of membranes were significantly lower in the placenta previa group (placenta previa: 2.0% vs. control: 14.7%, P < 0.01; 14.1% vs. 30.1%, P < 0.01; 7.1% vs. 17.6%, P < 0.05, respectively). The incidence of RDS was significantly higher in the placenta previa group than in the control group (29.3% vs. 6.9%, P < 0.0001). The cortisol level in umbilical cord blood in the placenta previa group was lower than in the control group (median 7.3, range 4.4-14.9 microg/dl vs. median 10.6, range 4.9-30.3 microg/dl, P < 0.05). There were no significant differences in epinephrine or norepinephrine levels between the two groups.
  
  
  CONCLUSIONS
  The incidence of RDS in infants delivered at 30-35 weeks' gestation by cesarean section was significantly higher in mothers with placenta previa than in women without placenta previa. This may reflect decreased fetal stress since the cord blood cortisol levels were found to be lower in women with placenta previa.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tokushima, School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Bekku
authors.forename: N
authors.initials: N
authors.lastname: Mitsuda
authors.forename: K
authors.initials: K
authors.lastname: Ogita
authors.forename: N
authors.initials: N
authors.lastname: Suehara
authors.forename: M
authors.initials: M
authors.lastname: Fujimura
authors.forename: T
authors.initials: T
authors.lastname: Aono
mesh_terms: D002585:Cesarean Section; D004837:Epinephrine / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005333:Fetus / Q000502:physiology; D005865:Gestational Age; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007231:Infant, Newborn; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010923:Placenta Previa / Q000150:complications*; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology* / Q000209:etiology; D013312:Stress, Physiological
chemical_list: D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine