title: Effect of partial liquid ventilation on pulmonary vascular permeability and edema after experimental acute lung injury.
abstract: We evaluated the effects of partial liquid ventilation (PLV) with two different dosages of the perfluorocarbon LiquiVent (perflubron) on pulmonary vascular permeability and edema formation after oleic acid (OA)-induced acute lung injury in dogs. We used imaging with positron emission tomography to measure fractional pulmonary blood flow, lung water concentration (LWC), and the pulmonary transcapillary escape rate (PTCER) of (68)Ga-labeled transferrin at 5 and 21 h after lung injury in five dogs undergoing conventional mechanical ventilation (CMV), five dogs undergoing low-dose PLV (perflubron at 10 ml/kg), and four dogs undergoing high dose PLV (perflubron at 30 ml/kg). A positive end-expiratory pressure of 7.5 cm H(2)O was used in all dogs. After OA (0.08 ml/kg)- induced lung injury, there were no significant differences or trends for PTCER or LWC at any time when the PLV groups were compared with the CMV group. However, lung tissue myeloperoxidase activity was significantly lower in the combined PLV group than in the CMV group (p = 0.016). We conclude that after OA-induced lung injury, the addition of PLV to CMV does not directly attenuate pulmonary vascular leak or lung water accumulation. Rather, the benefits of such treatment may be due to modifications of the inflammatory response.
authors.affiliation: Departments of Radiology, Pediatrics, and Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: N R
authors.initials: NR
authors.lastname: Lange
authors.forename: J K
authors.initials: JK
authors.lastname: Kozlowski
authors.forename: R
authors.initials: R
authors.lastname: Gust
authors.forename: S D
authors.initials: SD
authors.lastname: Shapiro
authors.forename: D P
authors.initials: DP
authors.lastname: Schuster
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D004285:Dogs; D005466:Fluorocarbons / Q000008:administration & dosage; D006439:Hemodynamics; D006842:Hydrocarbons, Brominated; D008168:Lung / Q000378:metabolism / Q000503:physiopathology*; D055370:Lung Injury; D010100:Oxygen / Q000378:metabolism; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D012121:Respiration, Artificial / Q000379:methods*
chemical_list: D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron; D010100:Oxygen