title: Constructive antagonism in limb development.
abstract: Several advances have been made in our understanding of the control of the growth and patterning of embryonic limbs. Development of the vertebrate limb is dependent on reciprocal interactions between the ectoderm and mesoderm that regulate the structure and function of the apical ectodermal ridge. One key component of this regulatory program appears to be the precise control of signaling by members of the bone morphogenetic protein family via multiple antagonistic interactions.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston 02143, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Dudley
authors.forename: C J
authors.initials: CJ
authors.lastname: Tabin
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D005121:Extremities / Q000196:embryology*; D005326:Fetal Proteins / Q000502:physiology; D000080865:Formins; D008840:Microfilament Proteins; D009687:Nuclear Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D005326:Fetal Proteins; D000080865:Formins; D008840:Microfilament Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors