title: Antioxidant status of surgical patients receiving TPN with an omega-3-fatty acid-containing lipid emulsion supplemented with alpha-tocopherol.
abstract: BACKGROUND
  LCT lipid emulsions and even more fish oil-containing lipid emulsions are under debate regarding their tocopherol and PUFA content as well as their effect on the antioxidative status especially in patients with oxidative stress.
  
  
  METHODS
  Thirty-three patients undergoing major abdominal surgery were randomly assigned to receive either an alpha-tocopherol-supplemented (562 micromol/l) MCT/LCT/omega-3-acid triglycerides (MLF, 5/4/1 w/w/w, 20%) emulsion or a soybean oil-based LCT emulsion (20%). The TPN regimen continuously provided 1.4 g fat kg bw(-1)d(-1)over 5 days.
  
  
  RESULTS
  Plasma antioxidant concentrations were strongly reduced by surgical treatment. Following 5 days of TPN with the MLF emulsion, mean plasma alpha-tocopherol increased by 20.0 micromol/l (1.98 micromol/mmol lipid), while nearly no change was observed in the LCT emulsion group. In both groups, plasma concentrations of all non-supplemented antioxidants (vitamin C, carotenoids, selenium) as well as serum total antioxidant capacity further decreased during TPN. The concentrations of plasma cholesterol oxidation products as a measure of in vivo lipid peroxidation revealed no changes over the TPN period in either group.
  
  
  CONCLUSIONS
  In contrast to the LCT emulsion, administration of the a-tocopherol supplemented MLF lipid emulsion normalized a-tocopherol plasma concentrations. Despite its high long-chain PUFA content, no hint for increased lipid peroxidation was found.
authors.affiliation: Institute of Nutrition Science, Technical University of Munich, Freising-Weihenstephan, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Linseisen
authors.forename: J
authors.initials: J
authors.lastname: Hoffmann
authors.forename: S
authors.initials: S
authors.lastname: Lienhard
authors.forename: K W
authors.initials: KW
authors.lastname: Jauch
authors.forename: G
authors.initials: G
authors.lastname: Wolfram
mesh_terms: D000005:Abdomen / Q000601:surgery; D000368:Aged; D000975:Antioxidants / Q000032:analysis* / Q000494:pharmacology; D005217:Fat Emulsions, Intravenous / Q000737:chemistry*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005217:Fat Emulsions, Intravenous; D015525:Fatty Acids, Omega-3; D008055:Lipids; D014810:Vitamin E