Pericentric inversion in human chromosome 8 and spherocytosis.
A cytogenetic study of a patient revealed a pericentric inversion in chromosome 8, and spherocytes in 10% of cells, in a routine blood smear. The critical portion which affected the expression of spherocytosis appeared to be localized at 8p22-8q21. The mother's karyotyping showed the transmission of the inversion to the child.
Ganguly
B B
BB
Centre for Research in Mental Retardation, Malad, Mumbai, India.
Dalvi
R
R
Mehta
A V
AV
D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002898:Chromosomes, Human, Pair 8; D002658:Developmental Disabilities / Q000235:genetics; D005192:Family Health; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D008540:Meiosis; D008957:Models, Genetic; D009035:Mothers; D013102:Spherocytes