title: The efficacy of 2.5% phenylephrine and flurbiprofen combined in inducing and maintaining pupillary dilatation during cataract surgery.
abstract: OBJECTIVE
  To evaluate the effectiveness of phenylephrine 2.5% and flurbiprofen 0.03% combined in inducing and maintaining mydriasis during extracapsular cataract extraction (ECCE).
  
  
  METHODS
  One hundred patients undergoing ECCE + intraocular lens (IOL) implantation were randomly divided into four groups. The first group was given phenylphrine 10%, the second group phenylephrine 10% + flurbiprofen, the third group phenylephrine 2.5% and fourth group phenylephrine 2.5% + flurbiprofen. Cyclopentolate 1% was used in all patients. Phenylephrine and cyclopentolate were instilled preoperatively four times during 1 hour and flurbiprofen was given four times the day before surgery and twice with an hour's interval before operation. Pre-operative and post-cortex aspiration horizontal pupil diameters were measured with callipers viewed through the operating microscope.
  
  
  RESULTS
  Pupil diameters in pre-operative and post-cortex aspiration were no different in the 2.5% and 10% phenylephrine groups (p>0.05). Both diameters were larger and pupillary constriction was smaller in the flurbiprofen groups (p<0.05).
  
  
  CONCLUSIONS
  2.5% phenylephrine was as effective as 10% phenylephrine, with and without flurbiprofen, in inducing and maintaining pupil dilatation during ECCE surgery.
authors.affiliation: Department of Ophthalmology, Celal Bayar University, Manisa, Turkey. fozturk@aku.edu.tr
authors.forename: F
authors.initials: F
authors.lastname: Oztürk
authors.forename: E
authors.initials: E
authors.lastname: Kurt
authors.forename: U U
authors.initials: UU
authors.lastname: Inan
authors.forename: S S
authors.initials: SS
authors.lastname: Ilker
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D002387:Cataract Extraction; D003519:Cyclopentolate / Q000008:administration & dosage / Q000494:pharmacology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005480:Flurbiprofen / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D019654:Lens Implantation, Intraocular; D015877:Miosis / Q000517:prevention & control; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects*; D013566:Sympathomimetics / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D013566:Sympathomimetics; D010656:Phenylephrine; D005480:Flurbiprofen; D003519:Cyclopentolate