title: Anti-aging medicine. 2. Efficacy and safety of hormones and antioxidants.
abstract: Little is known about the efficacy and safety of substances that are being promoted to consumers as "anti-aging" therapies. Hormones such as DHEA, human growth hormone, and testosterone tend to decline with aging, but the therapeutic value of replacing them to "normal" physiologic levels has not been substantiated by controlled clinical trials. The best source of antioxidants is a balanced diet, although older patients may benefit from vitamin E supplementation. Providing anti-aging medicine in the primary care setting means practicing good medicine. It means talking to patients who request these therapies and understanding why they want them and how much risk they're willing to take.
authors.affiliation: Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Butler
authors.forename: M
authors.initials: M
authors.lastname: Fossel
authors.forename: C X
authors.initials: CX
authors.lastname: Pan
authors.forename: D J
authors.initials: DJ
authors.lastname: Rothman
authors.forename: S M
authors.initials: SM
authors.lastname: Rothman
mesh_terms: D000375:Aging / Q000187:drug effects*; D000975:Antioxidants / Q000009:adverse effects / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000494:pharmacology; D004035:Diet Therapy; D017277:Drug Approval; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D006801:Humans; D018570:Risk Assessment; D014815:Vitamins / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D014815:Vitamins; D002118:Calcium