title: Pretreatment prognostic factors for children with hepatoblastoma-- results from the International Society of Paediatric Oncology (SIOP) study SIOPEL 1.
abstract: The aim of this study was to investigate the prognostic significance of pretreatment patient and tumour characteristics for overall (OS) and event-free (EFS) survival in 154 children affected by hepatoblastoma (HB) in the first prospective liver tumour study run by the International Society of Paediatric Oncology. The pretreatment characteristics studied were age, alpha-fetoprotein, platelet count, histology; from radiology: intrahepatic tumour extension (PRETEXT), lung metastases, enlarged hilar lymph nodes, vena cava or extrahepatic vena porta tumour extension and tumour focality. Five-year OS was 75% (95% confidence interval (CI) 68-82%) and EFS 66% (95% CI 59-74%). Both were univariately associated with PRETEXT and the presence of metastases. Additionally tumour focality and enlargement of hilar lymph nodes at diagnosis were univariately associated with EFS. In multivariate analysis, PRETEXT was the only predictor of OS; PRETEXT and metastases were predictors of EFS. There is a need to investigate further these factors to confirm their validity.
authors.affiliation: Northern and Yorkshire Clinical Trials and Research Unit, Arthington House, Hospital Lane, LS16 6QB, Leeds, UK. medjmb@leeds.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: G
authors.initials: G
authors.lastname: Perilongo
authors.forename: E
authors.initials: E
authors.lastname: Shafford
authors.forename: J
authors.initials: J
authors.lastname: Keeling
authors.forename: J
authors.initials: J
authors.lastname: Pritchard
authors.forename: P
authors.initials: P
authors.lastname: Brock
authors.forename: C
authors.initials: C
authors.lastname: Dicks-Mireaux
authors.forename: A
authors.initials: A
authors.lastname: Phillips
authors.forename: A
authors.initials: A
authors.lastname: Vos
authors.forename: J
authors.initials: J
authors.lastname: Plaschkes
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D018197:Hepatoblastoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008297:Male; D015999:Multivariate Analysis; D011300:Preoperative Care / Q000379:methods; D016019:Survival Analysis