title: [Parameters of lipid metabolism during perimenopause and thyroid pathology].
abstract: A total of 210 perimenopausal women were examined. Lipid status was evaluated in groups of patients differing by thyroid function and characteristics of the perimenopausal period. Case histories were analyzed using a universal information chart. Serum levels of T3, T4, TTH, LH, FSH, PRL, E2, and progesterone were radioimmunoassayed. Blood lipid spectrum was evaluated on a Kone device (Finland) by special standard methods. High levels of cholesterol and triglycerides, a tendency to an increase in CH-LDL and CH-VLDL, a decrease in CH-HDL, and a high atherogenicity coefficient were detected in women with endemic goiter and hypothyrosis in comparison with perimenopausal women without thyroid disease. The highest levels of cholesterol, triglycerides, CH-LDL, and atherogenicity coefficient were detected in women with endemic goiter and climacteric syndrome, which suggests that hypothyrosis in the presence of climacteric syndrome aggravates disordered lipid metabolism.
authors.forename: T M
authors.initials: TM
authors.lastname: Esedova
authors.forename: A E
authors.initials: AE
authors.lastname: Esedova
authors.forename: N Kh
authors.initials: NKh
authors.lastname: Nasrullaeva
authors.forename: M M
authors.initials: MM
authors.lastname: Gadzhieva
authors.forename: L V
authors.initials: LV
authors.lastname: Gurova
authors.forename: R A
authors.initials: RA
authors.lastname: Ferzilaeva
mesh_terms: D000375:Aging / Q000378:metabolism*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008593:Menopause / Q000378:metabolism*; D008875:Middle Aged; D013959:Thyroid Diseases / Q000378:metabolism* / Q000503:physiopathology