title: Intact functional inhibition in the surround of experimentally induced focal cortical dysplasias in rats.
abstract: Early postnatal injections of ibotenate into the rat neopallium induce cortical dysplasias mimicking human polymicrogyria which often goes along with seizure disorders. Under in vitro conditions these experimentally induced dysplasias cause widespread hyperexcitability. The underlying mechanisms are as yet not fully understood. Electrophysiologically there is clear evidence of widespread alterations of the excitatory system. Intracellular recordings also showed some changes of the inhibitory system but have concentrated on recordings from focal areas close to the microgyrus. We investigated the integrity of functional inhibition using a paired-pulse paradigm to map the whole ipsilateral hemisphere. In rat cortical slices double-pulses were applied in layer VI/white matter and field potentials recorded in layer II/III. The ratio of the field potential amplitude did not show significant alterations in the dysplasias or their surround as compared with control and sham-injected animals. This result was obtained with two different locations of the dysplasias, excluding a mere areal specific effect. Our results show that despite prominent hyperexcitability in the surround of ibotenate-induced cortical dysplasias the inhibitory network appears to be functionally intact.
authors.affiliation: Department of Neurology, Heinrich-Heine-University, D-40225 Duesseldorf, Germany. Georg.Hagemann@uni-duesseldorf.de
authors.forename: G
authors.initials: G
authors.lastname: Hagemann
authors.forename: C
authors.initials: C
authors.lastname: Redecker
authors.forename: O W
authors.initials: OW
authors.lastname: Witte
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000473:pathology*; D004195:Disease Models, Animal; D004594:Electrophysiology; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology*; D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid; D009410:Nerve Degeneration / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D009433:Neural Inhibition / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018690:Excitatory Amino Acid Agonists; D007051:Ibotenic Acid