title: An unusual concurrence of graft versus host disease caused by engraftment of maternal lymphocytes with DiGeorge anomaly.
abstract: We describe a girl with DiGeorge anomaly and normal cytogenetic and molecular studies, whose clinical course was complicated by graft versus host disease caused by intrauterine materno-fetal transfusion, and several immunohematological alterations including a monoclonal gammapathy of undetermined significance (first IgG, which subsequently changed to IgM). The main clinical features and pathological findings are discussed.
authors.affiliation: Servicio de Inmunología, Hospital Universitario "Marqués de Valdecilla", Instituto Nacional de la Salud, 39008 Santander, Spain.
authors.forename: J G
authors.initials: JG
authors.lastname: Ocejo-Vinyals
authors.forename: M J
authors.initials: MJ
authors.lastname: Lozano
authors.forename: P
authors.initials: P
authors.lastname: Sánchez-Velasco
authors.forename: J
authors.initials: J
authors.lastname: Escribano de Diego
authors.forename: J E
authors.initials: JE
authors.lastname: Paz-Miguel
authors.forename: F
authors.initials: F
authors.lastname: Leyva-Cobián
mesh_terms: D002675:Child, Preschool; D002678:Chimera; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D004062:DiGeorge Syndrome / Q000150:complications* / Q000235:genetics / Q000276:immunology; D017809:Fatal Outcome; D005260:Female; D005331:Fetomaternal Transfusion / Q000150:complications* / Q000235:genetics; D006086:Graft vs Host Disease / Q000150:complications* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D010375:Pedigree; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M