title: Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies.
abstract: The authors analyzed the relationship between nuclear genetic risk factors (apolipoprotein E genotype) and mitochondrial DNA (mtDNA) sequence variants in pathologically proved cases of AD (n = 185), dementia with Lewy bodies (DLB; n = 84), and control subjects (n = 179). Specific European mtDNA haplogroups and the A4336G mutation were not associated with an increased risk of AD. mtDNA haplogroup H was overrepresented in the DLB patients when compared with control subjects. Additional studies are needed to clarify the significance of the association.
authors.affiliation: Department of Neurology, The University of Newcastle upon Tyne, UK.
authors.forename: P F
authors.initials: PF
authors.lastname: Chinnery
authors.forename: G A
authors.initials: GA
authors.lastname: Taylor
authors.forename: N
authors.initials: N
authors.lastname: Howell
authors.forename: R M
authors.initials: RM
authors.lastname: Andrews
authors.forename: C M
authors.initials: CM
authors.lastname: Morris
authors.forename: R W
authors.initials: RW
authors.lastname: Taylor
authors.forename: I G
authors.initials: IG
authors.lastname: McKeith
authors.forename: R H
authors.initials: RH
authors.lastname: Perry
authors.forename: J A
authors.initials: JA
authors.lastname: Edwardson
authors.forename: D M
authors.initials: DM
authors.lastname: Turnbull
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000473:pathology; D004272:DNA, Mitochondrial / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D020961:Lewy Body Disease / Q000235:genetics* / Q000473:pathology; D012306:Risk
chemical_list: D001057:Apolipoproteins E; D004272:DNA, Mitochondrial