A patient of short stature with normal GH secretion, but a low serum IGF-I level.
We report the case of a 7-year-old patient of short stature who had normal GH secretion, but a very low serum IGF-I level. On admittance, his height and weight were 102.2 cm (-3.8S.D.) and 15.7 kg (-1.8S.D.), respectively. His bone age was 2 years and 8 months. The serum GH responses to insulin, glucagon and L-dopa were all normal. GH secretion during sleep was also normal, but the serum IGF-I level was very low (29 ng/ml). The serum IGF-I level was greatly increased by the administration of GH. No mutation was detected in the GH-1 gene. His height velocity was noticeably improved by GH treatment.
Mochizuki
D
D
Department of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan.
Kodama
H
H
Kubota
K
K
Mori
Y
Y
Nakamoto
N
N
Kobayashi
M
M
Yanagawa
Y
Y
Kaji
M
M
D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects; D002648:Child; D013006:Growth Hormone / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D012016:Reference Values
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone