title: Neuroleptic malignant syndrome associated with amoxapine and lithium in an older adult.
abstract: This report describes the presentation of neuroleptic malignant syndrome (NMS) in the primary care setting in an older adult with major depression with psychosis. This patient had been stable on a regimen of amoxapine, lithium carbonate, lorazepam, and benztropine. The patient had rigidity, altered sensorium, diaphoresis, autonomic instability, elevated WBC count and urine myoglobin, and creatine phosphokinase (CPK) reaching 1331 U/I. He was successfully treated with bromocriptine.
authors.affiliation: Department of Psychiatry SUNY Health Science Center at Syracuse, New York, USA.
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: A A
authors.initials: AA
authors.lastname: Racaniello
mesh_terms: D000657:Amoxapine / Q000009:adverse effects* / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D018692:Antimanic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D018021:Lithium Chloride / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology*; D011618:Psychotic Disorders / Q000188:drug therapy
chemical_list: D018687:Antidepressive Agents, Second-Generation; D018692:Antimanic Agents; D018021:Lithium Chloride; D000657:Amoxapine