title: Isolation of an attenuated myxoma virus field strain that can confer protection against myxomatosis on contacts of vaccinates.
abstract: Twenty MV strains obtained from a survey of field strains currently circulating throughout Spain were analyzed for their virulence and horizontal spreading among rabbits by contact transmission. A virus strain with suitable characteristics to be used as a potential vaccine against myxomatosis in wild rabbit populations was selected. Following inoculation, the selected MV strain elicited high levels of MV specific antibodies and induced protection of rabbits against a virulent MV challenge. Furthermore, the attenuated MV was transmitted to 9 out of 16 uninoculated rabbits by contact, inducing protection against myxomatosis.
authors.affiliation: Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Bárcena
authors.forename: A
authors.initials: A
authors.lastname: Pagès-Manté
authors.forename: R
authors.initials: R
authors.lastname: March
authors.forename: M
authors.initials: M
authors.lastname: Morales
authors.forename: M A
authors.initials: MA
authors.lastname: Ramírez
authors.forename: J M
authors.initials: JM
authors.lastname: Sánchez-Vizcaíno
authors.forename: J M
authors.initials: JM
authors.lastname: Torres
mesh_terms: D000818:Animals; D007114:Immunization; D009233:Myxoma virus / Q000276:immunology* / Q000472:pathogenicity; D011213:Poxviridae Infections / Q000517:prevention & control* / Q000635:transmission; D011817:Rabbits; D014412:Tumor Virus Infections / Q000517:prevention & control* / Q000635:transmission; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014774:Virulence
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines