[Comparative characteristics of vanadium-containing compounds, possessing insulin-like effects].
The serum glucose concentration, HbAc1, fructoseamine, the activity of AST, ALT, amylase, glycogen content and glucokinase activity in rat hepatocytes were examined in streptozotocin-diabetic rats during long-term orthovanadate and vanadyl sulphate treatment. The improvement of this parameters were demonstrated after oral orthovanadate and vanadyl sulphate administration. However, insulin-mimetic properties of vanadyl sulphate were more marked in comparison with orthovanadate. LD-50 and cytotoxicity analysis in isolated hepatocytes showed that vanadyl sulphate was less toxic than orthovanadate.
Golubev
M A
MA
Institute of Biomedical Chemistry RAMS, Moscow, Russia.
Gorodetskiĭ
V K
VK
Anis'kina
A P
AP
Tochilkin
A I
AI
Beliaeva
N F
NF
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007328:Insulin / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008297:Male; D018716:Molecular Mimicry; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D017968:Vanadium Compounds / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity
D007328:Insulin; D017968:Vanadium Compounds; D013311:Streptozocin