title: IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. II. Physico-chemical properties and structure determination.
abstract: IB-96212, is a new member of spiroketal containing macrolide class of fermentation-derived natural products isolated from mycelial extracts of Micromonospora sp. The structure consists of a new aglycone which possesses a 26-membered macrolide ring system and of one deoxy sugar identified as L-rhodinose, this structure represents the first reported spiroketal macrolide natural product related to other macrolides, such as oligomycins, dunaimycins, citovaricin, rutamycin and ossamycin.
authors.affiliation: Drug Discovery Division, Instituto Biomar SA, León, Spain.
authors.forename: L M
authors.initials: LM
authors.lastname: Cañedo
authors.forename: J L
authors.initials: JL
authors.lastname: Fernández-Puentes
authors.forename: J P
authors.initials: JP
authors.lastname: Baz
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D018942:Macrolides; D008847:Micromonospora / Q000378:metabolism*; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; C411677:IB 96212; D018942:Macrolides