An antimalarial stilbene from Artocarpus integer.
Antimalarial activity-guided study of the aerial parts of Artocarpus integer led to the isolation of the prenylated stilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2',4'-tetrahydroxystilbene with an EC50 of 1.7 micrograms/ml against Plasmodium falciparum in culture. The known stilbenes, trans-4-isopentenyl-3,5,2',4'-tetrahydroxystilbene and 4-methoxy-2,2-dimethyl-6-(2-(2,4-dihydroxy)phenyl-trans-ethenyl)chromene , were also isolated. Structures of these compounds were deduced on the basis of their spectral data.
Boonlaksiri
C
C
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Oonanant
W
W
Kongsaeree
P
P
Kittakoop
P
P
Tanticharoen
M
M
Thebtaranonth
Y
Y
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D013267:Stilbenes / Q000302:isolation & purification*
C416519:4-(3-methylbut-1-enyl)-3,5,2',4'-tetrahydroxystilbene; D000962:Antimalarials; D013267:Stilbenes