title: Radiographic scoring method for the assessment of the severity of nutritional rickets.
abstract: Radiographic changes of rickets are well characterized, but no method of grading the severity of these changes has been in general use. Consequently, it is difficult to compare objectively or follow radiographic improvement. We prospectively evaluated the utility and reproducibility of a scoring method for measuring the severity of rickets. A 10-point score for radiographs of wrists and knees was devised to assess the degree of metaphyseal fraying and cupping and the proportion of the growth plate affected. The score progresses in half point increments from zero (normal) to 10 points (severe). Four trained physicians independently scored radiographs on two separate occasions from 67 children with active rickets. A broad representation of mean radiographic scores was moderately correlated with alkaline phosphatase (r = 0.58). Interobserver correlation of radiographic scores was 0.84 or greater for all observer pairs and intraobserver correlation was 0.89 or greater for each observer. Researchers and clinicians should find the score useful to assess objectively the severity of rickets.
authors.affiliation: Department of Family Medicine, Jos University Teaching Hospital, Nigeria.
authors.forename: T D
authors.initials: TD
authors.lastname: Thacher
authors.forename: P R
authors.initials: PR
authors.lastname: Fischer
authors.forename: J M
authors.initials: JM
authors.lastname: Pettifor
authors.forename: J O
authors.initials: JO
authors.lastname: Lawson
authors.forename: B J
authors.initials: BJ
authors.lastname: Manaster
authors.forename: J C
authors.initials: JC
authors.lastname: Reading
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D002675:Child, Preschool; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging; D015588:Observer Variation; D011446:Prospective Studies; D011859:Radiography; D012279:Rickets / Q000145:classification / Q000000981:diagnostic imaging*; D012720:Severity of Illness Index; D014955:Wrist Joint / Q000000981:diagnostic imaging
chemical_list: D000469:Alkaline Phosphatase