Heat-killed Mycobacterium bovis-bacillus Calmette Guerin-suppressed total serum IgE response in ovalbumin-sensitized newborn mice.
To determine the impact of bacillus Calmette Guerin (BCG) vaccination on IgE production in ovalbumin (OVA)-sensitized newborn mice, four groups (I, II, III, IV) of BALB/c mice were immunized on the first day of life with live BCG, killed BCG, BCG diluent, and saline, respectively. No injection was applied to mice in group V (control). All mice except group V were sensitized and challenged with OVA in the fourth and sixth weeks, respectively, and serum total IgE levels were determined at 8 weeks, 2 weeks after the second OVA challenge. IgE levels of all groups were significantly higher than the control group except for group II (p = 0.95). Mice in group II showed significantly lower IgE values than group IV and I (p = 0.007 and p = 0.003, respectively). We concluded that heat-killed BCG may downregulate IgE response to OVA in newborn mice.
Bakir
M
M
Marmara University Hospital, Department of Pediatrics, Istanbul, Turkey.
Tükenmez
F
F
Bahçeciler
N N
NN
Barlan
I B
IB
Başaran
M M
MM
D000818:Animals; D000831:Animals, Newborn; D001500:BCG Vaccine / Q000276:immunology*; D015536:Down-Regulation / Q000276:immunology; D005260:Female; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D009163:Mycobacterium bovis / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology*; D011247:Pregnancy; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
D001500:BCG Vaccine; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated; D007073:Immunoglobulin E; D010047:Ovalbumin