A time-less function for mouse timeless.
The timeless (tim) gene is essential for circadian clock function in Drosophila melanogaster. A putative mouse homolog, mTimeless (mTim), has been difficult to place in the circadian clock of mammals. Here we show that mTim is essential for embryonic development, but does not have substantiated circadian function.
Gotter
A L
AL
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Manganaro
T
T
Weaver
D R
DR
Kolakowski
L F
LF
Possidente
B
B
Sriram
S
S
MacLaughlin
D T
DT
Reppert
S M
SM
D000818:Animals; D056926:CLOCK Proteins; D018797:Cell Cycle Proteins; D002678:Chimera; D002940:Circadian Rhythm / Q000235:genetics; D017930:Genes, Reporter; D006579:Heterozygote; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008156:Luciferases / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D010802:Phylogeny; D011994:Recombinant Proteins / Q000378:metabolism; D018411:Spodoptera; D013493:Suprachiasmatic Nucleus / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic; D014162:Transfection
D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; D011994:Recombinant Proteins; C509769:TIMELESS protein, human; C509770:Timeless protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D008156:Luciferases; D056926:CLOCK Proteins; C538943:CLOCK protein, human; C538944:Clock protein, mouse