Differential infectivity and division of Toxoplasma gondii in human peripheral blood leukocytes.
When tachyzoites were incubated with human peripheral blood leukocytes in vitro, more monocytes and dendritic cells than neutrophils or lymphocytes were infected. Although tachyzoites were able to divide in each of these cell types, monocytes and dendritic cells were more permissive to rapid tachyzoite division than neutrophils or lymphocytes.
Channon
J Y
JY
Departments of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. jacqueline.Channon@dartmouth.edu
Seguin
R M
RM
Kasper
L H
LH
D000818:Animals; D002455:Cell Division; D003713:Dendritic Cells / Q000469:parasitology; D005347:Fibroblasts / Q000469:parasitology; D006801:Humans; D007962:Leukocytes / Q000469:parasitology*; D008214:Lymphocytes / Q000469:parasitology; D009000:Monocytes / Q000473:pathology; D009504:Neutrophils / Q000469:parasitology; D014122:Toxoplasma / Q000166:cytology* / Q000472:pathogenicity*