Synthesis and antiviral activity of 3-(beta-D-ribofuranosyl)-1,2,4-oxadiazole-5-carboxamide.
3-(beta-D-Ribofuranosyl)-1,2,4-oxadiazole-5-carboxamide (5) was prepared by condensation reaction of amidoxime 6 with monoethyl oxaloyl chloride followed by reaction with ammonia. The compound 5, however, did not exhibit any significant activity against herpes simplex virus type-I (HSV-I) and semliki forest virus (SFV).
Pratap
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Central Drug Research Institute, Lucknow, India.
Yarovenko
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VN
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000378:metabolism; D051379:Mice; D012672:Semliki forest virus / Q000187:drug effects; D013329:Structure-Activity Relationship
C414824:5-(2-(4-N,N-dimethylaminophenyl)ethyl)-2'-deoxyuridine; C414823:5-(3-(N-methylphenylamino)propanoyl)-2'-deoxyuridine; D000998:Antiviral Agents; D007372:Interferons; D003857:Deoxyuridine