title: Herpes zoster in immunocompetent and immunocompromised Japanese children.
abstract: BACKGROUND
  To confirm epidemiological features of herpes zoster among children with or without immunosuppression, herpes zoster patients who had presented to this hospital were retrospectively investigated.
  
  
  METHODS
  Medical records were reviewed for the 92 cases of pediatric herpes zoster patients diagnosed during the period from 1981 to 1998. The age at onset of herpes zoster and of varicella, the interval between varicella and zoster, the dermatomal distribution of herpes zoster and complications were compared between immunocompetent and immunocompromised children.
  
  
  RESULTS
  The mean age at onset of zoster in immunocompetent children was 8.5 +/- 4.0 years and in immunosuppressed children was 9.7 +/- 3.8 years. The age at onset of varicella was significantly lower (1.6 +/- 1.8 years) in immunocompetent than in immunosuppressed children (4.6 +/- 2.7 years). The interval between varicella and zoster was 6.2 +/- 3.2 years in immunocompetent children. More than 80% of patients with acute leukemia or malignant lymphoma had herpes zoster within 2 years after diagnosis of malignancy. Lesions of herpes zoster were most frequently found in the thoracic nerve regions. Five of 11 zoster patients with cutaneous dissemination, three of five zoster patients having aseptic meningitis and three of four patients complicated facial palsy were children without underlying disease.
  
  
  CONCLUSIONS
  The present study confirmed that varicella in the first year of life was a risk factor in immunocompetent children, as reported previously. Herpes zoster in children without immunosuppression was found not to be as mild as generally accepted.
authors.affiliation: Department of Pediatrics, Tokyo Metropolitan Komagome Hospital, Japan. takyamnd-k@komagome-hospital.bunkyo.tokyo.jp
authors.forename: N
authors.initials: N
authors.lastname: Takayama
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Kaku
authors.forename: M
authors.initials: M
authors.lastname: Minamitani
mesh_terms: D017668:Age of Onset; D002644:Chickenpox / Q000150:complications / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006562:Herpes Zoster / Q000453:epidemiology / Q000276:immunology*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D014775:Virus Activation