title: Phe and Asn side chains in DNA double strands.
abstract: The contribution of amino acid side chains to the recognition of DNA by peptides or proteins is evaluated by substituting single nucleobases of a DNA double strand by amino acid side chains. C-nucleosides with the side chains of phenylalanine and asparagine were synthesized and incorporated in DNA. This modification should allow to keep the double strand conformation. Hydrogen bonds, pi-pi-interactions and solvation have an influence on the double strand stability.
authors.affiliation: Institut für Organische Chemnie, Universität Würzburg, Germany. diederichsen@chemie.uni-wuerzburg.de
authors.forename: U
authors.initials: U
authors.lastname: Diederichsen
authors.forename: C M
authors.initials: CM
authors.lastname: Biro
mesh_terms: D001216:Asparagine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D020137:Base Pair Mismatch; D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D009705:Nucleosides; D020135:Peptide Nucleic Acids; D010649:Phenylalanine; D001216:Asparagine; D004247:DNA