title: Effect of honey on naringin absorption from a decoction of the pericarps of Citrus grandis.
abstract: To measure naringin/naringenin absorption of a decoction prepared from the pericarps of Citrus grandis and to investigate the effect of honey on naringin/naringenin absorption, six healthy males received 200 mL decoctions of untreated and honey-treated Pericarpium Citri Grandis in a randomized crossover design. The absorption was measured by renal recovery of naringenin glucuronides/sulfates over 48 hours. The contents of naringin/naringenin in 200 mL decoctions of untreated and honey-treated Pericarpium Citri Grandis were determined to be 261.5/23.8 mumol and 303.3/11.6 mumol, respectively. The mean cumulated renal excretion of naringenin glucuronides/sulfates after intake of these two decoctions were 74.8 mumol (26.2% of dose) and 49.8 mumol (15.8% of dose), respectively. Paired Student's t-test showed that the difference of the total renal recovery of naringin/naringenin between the two decoctions was significant. The results indicated that honey significantly reduced naringin/naringenin absorption by 33.4% in humans and suggested that honey treatment might alter the efficacy of Pericarpium Citri Grandis.
authors.affiliation: Graduate Institute of Chinese Pharmaceutical Sciences, Taichung, Taiwan, R.O.C.
authors.forename: Y C
authors.initials: YC
authors.lastname: Hou
authors.forename: S L
authors.initials: SL
authors.lastname: Hsiu
authors.forename: H F
authors.initials: HF
authors.lastname: Yen
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: P D
authors.initials: PD
authors.lastname: Chao
mesh_terms: D000042:Absorption; D002851:Chromatography, High Pressure Liquid; D002957:Citrus / Q000737:chemistry*; D018592:Cross-Over Studies; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics; D005243:Feces / Q000737:chemistry; D044950:Flavanones; D005419:Flavonoids / Q000493:pharmacokinetics* / Q000652:urine; D005638:Fruit / Q000737:chemistry; D020719:Glucuronides / Q000652:urine; D006722:Honey; D006801:Humans; D008297:Male
chemical_list: D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; D020719:Glucuronides; C005273:naringenin; C005274:naringin