Pancreatitis associated with potassium bromide/phenobarbital combination therapy in epileptic dogs.
In a retrospective study, at least 10% of dogs receiving potassium bromide/phenobarbital combination therapy, compared with 0.3% of dogs receiving phenobarbital monotherapy, had probable pancreatitis. Pancreatitis may be a more frequent and more serious adverse effect of potassium bromide/phenobarbital combination therapy than has been reported previously.
Gaskill
C L
CL
Department of Anatomy and Physiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown.
Cribb
A E
AE
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001965:Bromides / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced / Q000662:veterinary*; D010634:Phenobarbital / Q000009:adverse effects* / Q000627:therapeutic use; D017680:Potassium Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies
D000927:Anticonvulsants; D001965:Bromides; D017680:Potassium Compounds; C039004:potassium bromide; D010634:Phenobarbital