Desquamation in the stratum corneum.
To maintain a constant thickness of the stratum corneum the desquamation rate and the de novo production of corneocytes is delicately balanced. Using a plantar stratum corneum model we have obtained evidence that proteolysis is a central event in the desquamation process. A number of regulatory mechanisms for desquamation have been postulated based on our findings.
Egelrud
T
T
Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Sweden. torbjorn.egelrud@dermven.umu.se
D002448:Cell Adhesion; D002454:Cell Differentiation; D002470:Cell Survival; D004792:Enzyme Precursors / Q000502:physiology; D000078404:Epidermal Cells; D004817:Epidermis / Q000201:enzymology / Q000502:physiology*; D005110:Extracellular Space / Q000737:chemistry / Q000502:physiology; D006801:Humans; D007610:Kallikreins; D008055:Lipids / Q000737:chemistry / Q000502:physiology; D010539:Permeability; D012697:Serine Endopeptidases / Q000502:physiology
D004792:Enzyme Precursors; D008055:Lipids; C082472:KLK7 protein, human; D007610:Kallikreins; D012697:Serine Endopeptidases