Age-related change of neuropeptide Y-immunoreactive neurons in the rat main olfactory bulb.
The change of neuropeptide Y (NPY)-immunoreactive (IR) neurons in the rat main olfactory bulb as a result of aging was investigated at several aging stages over a two-year period; postnatal 1-24 months (P 1-P 24). From P 1 to P 12, the number of NPY-IR neurons and fibers increased with highest number in P 12, and the type of NPY-IR neurons had changed from bipolar neurons with short processes to bipolar/multipolar neurons with long processes. At P 24 the population of NPY-IR neurons and fibers had significantly decreased. Furthermore, the morphology of NPY-IR neurons showed a tendency to decrease in size and processes. It is suggested that the decrease of the number and size of NPY-IR neurons and fibers may underlie the age-related changes in the olfactory processes.
Won
M H
MH
Department of Anatomy, College of Medicine, Hallym University, 200-702, Chunchon, South Korea. mhwon@sun.hally.ac.kr
Kang
T C
TC
Lee
J C
JC
Choi
K Y
KY
Park
S K
SK
Jeong
Y G
YG
Jo
S M
SM
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000502:physiology; D007150:Immunohistochemistry; D009474:Neurons / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D009478:Neuropeptide Y / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D009830:Olfactory Bulb / Q000737:chemistry / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D009478:Neuropeptide Y