Palladium-Catalyzed cross-Benzannulation of Aminoenynes with Diynes. Highly Regioselective Synthesis of Polysubstituted Anilines.
Polysubstituted anilines were prepared by the palladium-catalyzed cross-benzannulation of conjugated aminoenynes 1-4 with diynes 8. The reaction proceeded in a highly regioselective manner under mild conditions, and the anilines were obtained as single regioisomers. Our method complements the well-known precedures for the preparation of polysubstituted anilines which are widely used in organic synthesis.
Saito
S
Institute for Chemical Reaction Science, Tohoku University, Sendai, 980-8578, Japan, and Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Uchiyama
N
Gevorgyan
V
Yamamoto
Y