title: Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum.
abstract: The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)2, VO(picolinate)2 and VO(6-Me-picolinate)2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account.
authors.affiliation: Department of Inorganic and Analytical Chemistry, József Attila University, Szeged, Hungary. tkiss@chem.u-szeged.hu
authors.forename: T
authors.initials: T
authors.lastname: Kiss
authors.forename: E
authors.initials: E
authors.lastname: Kiss
authors.forename: E
authors.initials: E
authors.lastname: Garribba
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D019343:Citric Acid / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000494:pharmacology; D019344:Lactic Acid / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry; D010848:Picolinic Acids / Q000737:chemistry; D012709:Serum Albumin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D014638:Vanadates / Q000097:blood*
chemical_list: D007328:Insulin; D008024:Ligands; D010710:Phosphates; D010848:Picolinic Acids; D012709:Serum Albumin; D014168:Transferrin; D019343:Citric Acid; D019344:Lactic Acid; D014638:Vanadates