Radical cyclization of beta-aminoacrylates: synthesis of (-)-indolizidine 223AB.
[reaction: see text] (-)-Indolizidine 223AB was synthesized via radical cyclization of the beta-aminoacrylate derivative of a trans-2,5-disubstituted pyrrolidine. The trans-2,5-disubstituted pyrrolidine substrate was prepared by radical cyclization of a Ses-protected beta-aminoacrylate.
Lee
E
E
School of Chemistry and Molecular Engineering, Seoul National University, Seoul, 151-742, Korea.
Jeong
E J
EJ
Min
S J
SJ
Hong
S
S
Lim
J
J
Kim
S K
SK
Kim
H J
HJ
Choi
B G
BG
Koo
K C
KC
D000818:Animals; D001001:Anura / Q000378:metabolism; D003500:Cyclization; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis*; D007212:Indolizines; D012867:Skin / Q000737:chemistry
D007202:Indicators and Reagents; D007211:Indoles; D007212:Indolizines; C413142:indolizidine 223AB