Phosphinooxazolines--a new class of versatile, modular P,N-ligands for asymmetric catalysis.
Chiral phosphinooxazolines (PHOX ligands), which coordinate to a metal center with a N- and a P-atom, allow effective enantiocontrol in a variety of metal-catalyzed reactions. They are readily synthesized, and because of their modular structure, the steric and electronic properties can be tailored for a specific application by variation of the oxazoline ring, the backbone, and the phosphine moiety.
Helmchen
G
G
Institut für Organische Chemie, Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany.
Pfaltz
A
A
D002384:Catalysis; D008024:Ligands; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis / Q000737:chemistry*; D012413:Rubidium / Q000737:chemistry; D013237:Stereoisomerism
D008024:Ligands; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D010080:Oxazoles; D010720:Phosphines; D010165:Palladium; D012413:Rubidium