title: Solid-phase peptide synthesis in the reverse (N --> C) direction.
abstract: [reaction: see text] A new strategy for SPPS in the reverse direction based on the use of 2-Cl-trityl resin, an allyl ester as the temporary protecting group, and Cu(OBt)(2)/DIPCDI or HATU/DIEA as the coupling method is described. These conditions ensure good yields with minimal racemization of the C-terminal residue.
authors.affiliation: Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Thieriet
authors.forename: F
authors.initials: F
authors.lastname: Guibé
authors.forename: F
authors.initials: F
authors.lastname: Albericio
mesh_terms: D001671:Biochemistry / Q000379:methods*; D010455:Peptides / Q000138:chemical synthesis*
chemical_list: D010455:Peptides