title: Clinicopathological implication of cripto expression in early stage invasive cervical carcinomas.
abstract: This study evaluates the expression of cripto (CR-1) protein in matched sets of non-neoplastic cervical epithelium, primary cervical carcinoma and metastatic tumours in the lymph nodes to investigate its role in uterine cervical cancer development and progression. Ninety-four primary cervical carcinomas in an early clinical stage and having the same surgical treatment modality were analysed. Immunoreactivity in the primary tumour was compared with that of non-neoplastic cervical epithelium and metastatic lymph nodes. The conventional clinicopathological prognostic variables for cervical carcinomas such as grade, tumour size, depth of invasion, parametrial and endometrial extension, lymphovascular space involvement and lymph node metastasis status were also compared with CR-1 expression of the primary tumour. Strong CR-1 immunopositivity was significantly correlated with tumour size and lymphovascular space involvement (P < 0.05). Furthermore, a significant relationship was found between CR-1 immunoreactivity and endometrial extension as well as parametrial involvement (P < 0.05). Interestingly, the CR-1 expression level was increased in metastatic lymph nodes compared with their primary tumours. These results suggest that CR-1 may contribute to disease progression in cervical carcinomas.
authors.affiliation: Department of Pathology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Ertoy
authors.forename: A
authors.initials: A
authors.lastname: Ayhan
authors.forename: E
authors.initials: E
authors.lastname: Saraç
authors.forename: E
authors.initials: E
authors.lastname: Karaağaoğlu
authors.forename: W
authors.initials: W
authors.lastname: Yasui
authors.forename: E
authors.initials: E
authors.lastname: Tahara
authors.forename: A
authors.initials: A
authors.lastname: Ayhan
mesh_terms: D004815:Epidermal Growth Factor; D005260:Female; D005500:Follow-Up Studies; D058851:GPI-Linked Proteins; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins; D008207:Lymphatic Metastasis; D008562:Membrane Glycoproteins; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging / Q000379:methods; D011379:Prognosis; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D058851:GPI-Linked Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C070636:TDGF1 protein, human; D004815:Epidermal Growth Factor