A convenient synthesis of a novel nucleoside analogue: 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone.
The nucleoside analogue 4-(alpha-diformyl-methyl)-1-(beta-D-ribofuranosyl)-2-pyrimidinone (5) was prepared from the corresponding 4-methyl pyrimidinone nucleoside by means of the Vilsmeier reaction. The unprotected nucleoside can be phosphorylated directly with phosphorus oxychloride in triethyl phosphate.
Gao
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K
Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Orgel
L E
LE
D002851:Chromatography, High Pressure Liquid; D003562:Cytidine / Q000138:chemical synthesis*; D005663:Furans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*
C414832:4-(diformyl-methyl)-1-(ribofuranosyl)-2-pyrimidinone; D005663:Furans; D011741:Pyrimidine Nucleosides; D003562:Cytidine