Recent advances in structure, binding sites with ligands and pharmacological function of beta-adrenoceptors obtained by molecular biology and molecular modeling.
The structure, binding sites interacting with ligands and the physiological functions of G-protein coupled beta-adrenoceptors (beta-ARs) are being elucidated by molecular biology and molecular modeling studies. The definition given amino acid sequences of beta-ARs in molecular biology and the analysis of three-dimensional and functional binding sites interacting with ligands by molecular modeling may be important for identifying other functional beta-ARs in various tissues and discovering new drugs. Thus, this review focuses on the interaction sites for receptor-ligand and roles of functional beta-ARs as studied by molecular biology and molecular modeling.
Nagatomo
T
T
Department of Pharmacology, Niigata College of Pharmacy, Japan. nagatomo@niigata-pharm.ac.jp
Koike
K
K
D000318:Adrenergic beta-Agonists / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000595:Amino Acid Sequence; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D011943:Receptors, Adrenergic, beta / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta