The trouble with tribbles.
Cell division and cell movements must be coordinated during development. A novel inhibitor of cell division, Tribbles, has been identified that blocks mitosis at a critical point in Drosophila morphogenesis. The data support a role for Tribbles in promoting proteolytic degradation of String/Cdc25, a key regulator of mitosis.
Johnston
L A
LA
B2-152, Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. lajohnst@fred.fhcrc.org
D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D002455:Cell Division / Q000235:genetics; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000378:metabolism; D047108:Embryonic Development; D018507:Gene Expression Regulation, Developmental; D010749:Phosphoprotein Phosphatases / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017027:Protein Tyrosine Phosphatases
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; C410505:trbl protein, Drosophila; D017346:Protein Serine-Threonine Kinases; D010749:Phosphoprotein Phosphatases; D017027:Protein Tyrosine Phosphatases; C059217:stg protein, Drosophila