title: CD4(+) lymphocyte-mediated suppression of cytomegalovirus expression in human astrocytes.
abstract: Cytomegalovirus-stimulated CD4(+) lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4(+) lymphocytes play a role in defense of the brain against cytomegalovirus.
authors.affiliation: Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Cheeran
authors.forename: G
authors.initials: G
authors.lastname: Gekker
authors.forename: S
authors.initials: S
authors.lastname: Hu
authors.forename: S L
authors.initials: SL
authors.lastname: Yager
authors.forename: P K
authors.initials: PK
authors.lastname: Peterson
authors.forename: J R
authors.initials: JR
authors.lastname: Lokensgard
mesh_terms: D001253:Astrocytes / Q000276:immunology / Q000821:virology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D003587:Cytomegalovirus / Q000502:physiology*; D006801:Humans; D014779:Virus Replication / Q000276:immunology