title: Attenuation of circadian rhythms of food intake and respiration in aging diabetes-prone BHE/Cdb rats.
abstract: The hypothesis that BHE/Cdb rats with mutations in their mitochondrial genome might accommodate this mutation by changing their food intake patterns was tested. Four experiments were conducted. Experiments 1 and 2 examined food intake patterns of BHE/Cdb rats fed a stock diet or BHE/Cdb and Sprague-Dawley rats fed a high-fat diet from weaning. Experiment 3 examined the daily rhythms of respiration and heat production in these rats at 200 days of age. Experiment 4 examined the effects of diet composition on these measurements at 50-day intervals. The Sprague-Dawley rats, regardless of diet, had the typical day-night rhythms of feeding and respiration. In contrast, the BHE/Cdb rats fed the high-fat diet showed normal rhythms initially, but with age, these rhythms were attenuated. The changes in rhythms preceded the development of glucose intolerance.
authors.affiliation: Department of Foods and Nutrition, University of Georgia, Athens, Georgia 30602, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Mathews
authors.forename: K
authors.initials: K
authors.lastname: Wickwire
authors.forename: W P
authors.initials: WP
authors.lastname: Flatt
authors.forename: C D
authors.initials: CD
authors.lastname: Berdanier
mesh_terms: D000375:Aging / Q000235:genetics*; D000704:Analysis of Variance; D000818:Animals; D019540:Area Under Curve; D001786:Blood Glucose; D002153:Calorimetry, Indirect; D002940:Circadian Rhythm / Q000235:genetics*; D003920:Diabetes Mellitus / Q000097:blood / Q000235:genetics*; D018752:Diet, Fat-Restricted; D004041:Dietary Fats / Q000378:metabolism; D004435:Eating / Q000235:genetics*; D005247:Feeding Behavior / Q000502:physiology; D020022:Genetic Predisposition to Disease; D005951:Glucose Tolerance Test; D005990:Glycerol / Q000097:blood; D008297:Male; D008928:Mitochondria / Q000235:genetics; D017440:Photoperiod; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D012119:Respiration / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D014280:Triglycerides; D005990:Glycerol