[Effect of the dopamine antagonist metoclopramide on uterine contraction].
BACKGROUND
Because of its activity on the gastro-intestinal tract metoclopramide is used also in pregnancy, though nothing is known about its effect on the pregnant uterus. Therefore it was of interest to look after a change in uterine activity after the application of metoclopramide in a clinical relevant dose.


METHODS
24 strips from pregnant uteri were removed during a cesarean section, brought into an organ chamber and changes of spontaneous activity after the application of metoclopramide were measured.


RESULTS
A highly significant decrease of uterine activity was observed.


CONCLUSIONS
It was demonstrated that metoclopramide, in contrast to stomach and ureter, exerts not a tonifying but a relaxant effect on the uterus.
Lechner
W
W
Universitätsklinik für Frauenheilkunde, Innsbruck.
Bergant
A
A
D046508:Culture Techniques; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008787:Metoclopramide / Q000494:pharmacology*; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
D018492:Dopamine Antagonists; D008787:Metoclopramide