title: ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism.
abstract: Biosynthesis of many classes of secondary metabolites in plants is induced by the stress hormone jasmonate. The gene for ORCA3, a jasmonate-responsive APETALA2 (AP2)-domain transcription factor from Catharanthus roseus, was isolated by transferred DNA activation tagging. Orca3 overexpression resulted in enhanced expression of several metabolite biosynthetic genes and, consequently, in increased accumulation of terpenoid indole alkaloids. Regulation of metabolite biosynthetic genes by jasmonate-responsive AP2-domain transcription factors may link plant stress responses to changes in metabolism.
authors.affiliation: Institute of Molecular Plant Sciences, Clusius Laboratory, Leiden University, Wassenaarseweg 64, 2333 AL, Leiden, Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: van der Fits
authors.forename: J
authors.initials: J
authors.lastname: Memelink
mesh_terms: D000085:Acetates / Q000494:pharmacology; D002460:Cell Line; D003517:Cyclopentanes / Q000494:pharmacology; D004269:DNA, Bacterial; D018506:Gene Expression Regulation, Plant; D018398:Homeodomain Proteins / Q000737:chemistry; D019684:Magnoliopsida / Q000235:genetics*; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry; D054883:Oxylipins; D010937:Plant Growth Regulators / Q000494:pharmacology; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D014748:Vinca Alkaloids / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D000085:Acetates; D003517:Cyclopentanes; D004269:DNA, Bacterial; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; C410983:ORCA3 protein, plant; D054883:Oxylipins; D010937:Plant Growth Regulators; D010940:Plant Proteins; C036483:T-DNA; D014157:Transcription Factors; D014748:Vinca Alkaloids; C072239:methyl jasmonate