title: Measurements of human brain ethanol T(2) by spectroscopic imaging at 4 T.
abstract: Previous MRS measurements of ethanol in human brain have yielded a range of transverse relaxation times for ethanol methyl resonance at 1.5 T (200-380 ms). To determine the T(2) of the methyl proton resonance of ethanol in human brain, 8 x 8 spectroscopic images were acquired at 16 different TE values. A frequency-selective refocusing pulse was used to suppress J-modulation of the ethanol triplet, permitting nonintegral multiples of 1/J to be used for TE values. The measured T(2) values for the methyl resonances of ethanol, creatine, and N-acetyl aspartate in mixed tissues were 82 +/- 12, 148 +/- 20, and 227 +/- 25 ms, respectively. Regression analysis of the measured T(2) as a function of gray matter content indicates a shorter T(2) value for ethanol in pure white matter compared to that in pure gray matter. Magn Reson Med 44:35-40, 2000.
authors.affiliation: Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973, USA. msammi@bnl.gov
authors.forename: M K
authors.initials: MK
authors.lastname: Sammi
authors.forename: J W
authors.initials: JW
authors.lastname: Pan
authors.forename: F W
authors.initials: FW
authors.lastname: Telang
authors.forename: D
authors.initials: D
authors.lastname: Schuhlein
authors.forename: P E
authors.initials: PE
authors.lastname: Molina
authors.forename: N D
authors.initials: ND
authors.lastname: Volkow
authors.forename: C S
authors.initials: CS
authors.lastname: Springer
authors.forename: H P
authors.initials: HP
authors.lastname: Hetherington
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged
chemical_list: D000431:Ethanol