[Liver transplantation with a graft taken from a heart transplant patient who was brain-dead].
The shortage of organ donors has led to progressive softening of selection criteria for organ donation. We report on hepatic transplantation in a 55-year-old woman with primary biliary cirrhosis, whose donor was a 50-year-old heart transplant recipient who became brain stem dead, due to cerebral bleeding 8 months after transplantation. An orthotopic liver transplantation was performed. The postoperative course was uneventful and the recipient was alive and had normal liver function after a 42-month follow-up. Analysis of the literature included ethical consideration, potential hepatotoxic effects of immunosuppressive drugs and modification of the graft immunogenicity. It confirms that transplanted patients should not be a priori excluded from organ donation.
Arvieux
C
C
Service de chirurgie générale et digestive, Grenoble, France.
Létoublon
C
C
Bouchard
F
F
Pasquier
D
D
Delecour
T
T
Barnoud
D
D
Penillon
S
S
Barnoud
R
R
Sturm
J M
JM
Hodaj
H
H
Borel
E
E
Naud
G
G
Pirenne
J
J
Zarski
J P
JP
D001926:Brain Death; D002543:Cerebral Hemorrhage / Q000150:complications; D004992:Ethics, Medical; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008105:Liver Cirrhosis, Biliary / Q000601:surgery; D016031:Liver Transplantation; D008875:Middle Aged; D014019:Tissue Donors
D007166:Immunosuppressive Agents