Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder.
A previous report [Blouin et al., 1998: Nat Genet 20:70-73] suggesting linkage to chromosomes 13q32 and 8p21 in families with schizophrenia led us to investigate these regions in a large set of 301 multiplex families with schizophrenia. Multipoint analyses failed to reveal evidence for linkage to any portion of chromosome 13, while only a weakly positive score was present on 8p using the identical marker reported in the earlier report. Failure to confirm the Blouin et al claims in a substantially larger cohort adds emphasis to the inconsistency of the findings concerning linkage in schizophrenia. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:235-239, 2000.
DeLisi
L E
LE
Department of Psychiatry, SUNY Stony Brook, Stony Brook, New York 11794, USA. LdeLisi@notes.cc.sunysb.edu
Shaw
S
S
Crow
T J
TJ
Shields
G
G
Smith
A B
AB
Larach
V W
VW
Wellman
N
N
Loftus
J
J
Nathankumar
B
B
Razi
K
K
Kushner
M
M
Stewart
J
J
Vita
A
A
Comazzi
M
M
Sherrington
R
R
D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D018709:Statistics, Nonparametric
D005819:Genetic Markers