[Activation of coagulation cascade in children during an idiopathic nephrotic syndrome relapse].
The objective of this study was to assess concentrations of selected markers of coagulation in children with relapse of idiopathic nephrotic syndrome during a 6-week therapy. Study groups: 22 subjects (32 relapses)--14 males, 8 females (mean age 7.15 +/- 1.5 y.) with no thrombotic complications were included into the study. All children were clinically steroid-sensitive.


METHODS
Coagulation markers (platelet count, thrombin time, APTT, INR, fibrinogen 1 + 2 fragments (F1 + 2), thrombin-antithrombin complexes (TAT), serum levels of D-dimer (DD), fibrin monomers (FM) and antithrombin activity (ATIII)) were measured three times: on admission, after 2 and 6 weeks. The control group consisted of 13 healthy children.


RESULTS
Serum concentration of TAT or F1 + 2 did not differ between 3 stages (p > 0.05). However, values at 0 and 2 weeks were significantly higher than in control group (p < 0.05). We found no correlation between TAT or F1 + 2 and FBG, ALB, TCH, TG levels. [table: see text]


CONCLUSIONS
The coagulation cascade in relapse of NS was activated during first 6 weeks of therapy whereas metabolic disturbances (low ALB, high FGB, TCH, TG, high platelets) normalized. It is speculative whether it was caused by active immunological process but definitely it resulted in "prothrombotic state" in INS patients.
Tkaczyk
M
M
Kliniki Nefrologii i Dializoterapii, z Pracowni Krzepniecia i Fibrynolizy Zakładu Diagnostyki Laboratoryjnej.
Owczarek
D
D
Puczko-Nogal
B
B
Makosiej
R
R
Rogowska-Kalisz
A
A
Ptaśnik
W
W
Finke
D
D
D000293:Adolescent; D015415:Biomarkers; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000378:metabolism*; D012008:Recurrence
D015415:Biomarkers; D001779:Blood Coagulation Factors; D005340:Fibrinogen