title: [Screening for transitional cell carcinoma of the bladder with trophoblastic differentiation in Upper Galilee].
abstract: Urinary bladder carcinoma with trophoblastic differentiation (TD) is a variant of urothelial (transitional cell) carcinoma (TCC) which secretes placental proteins, predominantly beta-human chorionic gonadotropin (HCG). An aggressive clinical course and a poor prognosis are characteristic of this tumor. We evaluated the frequency and clinical and pathological appearance of TCC-TD in the Upper Galilee and Golan Heights between 1988 and 1995 inclusive. Beta HCG, human placental lactogen (HPL), pregnancy specific beta-1 glycoprotein (SP-1) and placental alkaline phosphatase were determined immunohistochemically in paraffin-embedded TCC of urinary bladder. Tumor grade, stage and patient survival were also determined. There was beta-HCG immunostaining in 13 of 62 cases (20.9%). TD was correlated with higher grades of TCC and with advanced stages of disease. No cases of TCC-TD were found in grade 1, stage 0. Co-expression of beta-HCG and HPL was displayed in 2 cases, beta-HCG and SP-1 in 9, and beta-HCG, HPL and SP-1 in 2. Disease-free survival and overall survival were shorter in TCC-TD.
authors.affiliation: Division of Cytology, Rebecca Sieff Government Hospital, Safed.
authors.forename: M
authors.initials: M
authors.lastname: Moldavsy
authors.forename: A
authors.initials: A
authors.lastname: Sazbon
authors.forename: N
authors.initials: N
authors.lastname: Kuchersky
authors.forename: H
authors.initials: H
authors.lastname: Turani
mesh_terms: D000368:Aged; D000469:Alkaline Phosphatase / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000032:analysis; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D009367:Neoplasm Staging; D010928:Placental Lactogen / Q000032:analysis; D011247:Pregnancy; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis; D015996:Survival Rate; D014328:Trophoblastic Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000473:pathology / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human; D011268:Pregnancy-Specific beta 1-Glycoproteins; D010928:Placental Lactogen; D000469:Alkaline Phosphatase