Coronary smooth muscle and endothelial adaptations to exercise training.
Exercise training produces complex changes in intrinsic control of coronary vascular resistance. In smooth muscle, adaptations that alter Ca2+ regulation seem central, including changes in the function of sarcolemmal K+ and L-type Ca2+ channels and the sarcoplasmic reticulum. Exercise training also increases the ability of the endothelium to release vasoactive factors, with increased expression and activity of endothelial cell nitric oxide synthase playing a key role.
Bowles
D K
DK
Department of Veterinary Biomedical Sciences, University of Missouri, Columbia 65211, USA. BowlesD@missouri.edu
Woodman
C R
CR
Laughlin
M H
MH
D000222:Adaptation, Physiological / Q000502:physiology*; D003331:Coronary Vessels / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical