title: Enoxaparin and bleeding complications: a review in patients with and without renal insufficiency.
abstract: OBJECTIVE
  To compare the frequency of bleeding complications from enoxaparin in patients with normal renal function versus patients with renal insufficiency.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  University-based tertiary care center.
  
  
  METHODS
  One hundred six patients who received two or more doses of enoxaparin.
  
  
  RESULTS
  Total bleeding complications occurred in 22% of patients with normal renal function and 51% with renal insufficiency (p<0.01). Major bleeds were also significantly different, 2% and 30%, respectively (p<0.001). No patients with normal renal function were given fresh-frozen plasma or packed red blood cells, whereas in those with renal insufficiency, 13% and 32%, respectively, received these products (p<0.01).
  
  
  CONCLUSIONS
  Enoxaparin may have resulted in increased bleeding complications and use of blood products in patients with renal insufficiency. Prospective studies need to be conducted to define the drug's role and dosage adjustments in these patients.
authors.affiliation: Department of Pharmacy, Ohio State University Medical Center, Columbus 43210, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Gerlach
authors.forename: K K
authors.initials: KK
authors.lastname: Pickworth
authors.forename: S K
authors.initials: SK
authors.lastname: Seth
authors.forename: S B
authors.initials: SB
authors.lastname: Tanna
authors.forename: J F
authors.initials: JF
authors.lastname: Barnes
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects*; D017984:Enoxaparin / Q000009:adverse effects*; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000097:blood / Q000150:complications*; D012189:Retrospective Studies
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin