title: [Variability and development of viral populations: assessment and implications].
abstract: RNA virus populations consist of complex distributions of closely related but not identical genomes known as viral quasi-species. The quasi-species concept describes the dynamics of these genomes subjected to a continuous process of variation, competition, and selection. Quasi-species dynamics has broad implications not only in the understanding of the molecular mechanisms underlying adaptation of RNA viruses but also in the design of strategies for control and prevention of viral disease. Viral load and genetic heterogeneity have a determinant influence on the adaptation of RNA virus to their environment. Vaccines designed to control diseases caused by highly variable viruses must contain several B and T epitopes to provide an ample and diversified immune response. Similarly, antiviral drugs should be used in combination therapy to minimize selection of resistant viruses. The theoretical model of quasi-species has opened the way for new antiviral therapies based on augmentation of the mutation rate during replication of viral RNA. Finally the quasi-species concept provides the basis for defining the selective factors that could influence the evolution of RNA virus and promote the emergence or reemergence of viral diseases.
authors.affiliation: Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Universidad Autonoma de Madrid, Cantoblanco, España. edomingo@cbm.uam.es
authors.forename: E
authors.initials: E
authors.lastname: Baranowski
authors.forename: C M
authors.initials: CM
authors.lastname: Ruiz-Jarabo
authors.forename: C
authors.initials: C
authors.lastname: Escarmis
authors.forename: E
authors.initials: E
authors.lastname: Domingo
mesh_terms: D000898:Antibiosis; D000998:Antiviral Agents / Q000627:therapeutic use; D000939:Epitopes / Q000276:immunology; D014644:Genetic Variation; D016679:Genome, Viral; D006801:Humans; D008967:Molecular Biology; D009154:Mutation / Q000235:genetics; D012327:RNA Virus Infections / Q000517:prevention & control; D012328:RNA Viruses / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D012641:Selection, Genetic; D019562:Viral Load; D014765:Viral Vaccines / Q000276:immunology; D014779:Virus Replication / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D000939:Epitopes; D014765:Viral Vaccines