title: Feverfew for preventing migraine.
abstract: BACKGROUND
  Feverfew (Tanacetum parthenium L.) is a popular herbal remedy for migraine.
  
  
  OBJECTIVE
  To systematically review the evidence for or against the efficacy of feverfew versus placebo for the prevention of migraine.
  
  
  METHODS
  Electronic literature searches were performed using the databases CISCOM (Research Council for Complementary Medicine, London, UK), MEDLINE, EMBASE, Biosis and the Cochrane Library (each from its inception to April 1998). Manufacturers were contacted and the bibliographies of identified articles checked for further trials.
  
  
  METHODS
  Randomised, placebo-controlled, double-blind trials assessing the efficacy of feverfew for preventing migraine were included. No restrictions regarding the language of publication were imposed.
  
  
  METHODS
  Data on patients, interventions, methods, outcomes and results were extracted in a pre-defined, standardised manner. Methodological quality was evaluated using the scoring system developed by Jadad and colleagues. Both data extraction and the assessment of methodological quality were performed independently by two reviewers.
  
  
  RESULTS
  Four trials met the inclusion criteria. The majority of these trials suggested beneficial effects of feverfew compared with placebo. However, the trial with the highest methodological quality, which was also among the largest, found no significant difference between feverfew and placebo.
  
  
  CONCLUSIONS
  The efficacy of feverfew for the prevention of migraine has not been established beyond reasonable doubt.
authors.affiliation: Department of Complementary Medicine, School of Postgraduate Medicine & Health Sciences, University of Exeter, United Kingdom, 25 Victoria Park Road, Exeter, Devon, UK, EX2 4NT. M.H.Pittler@exeter.ac.uk
authors.forename: M H
authors.initials: MH
authors.lastname: Pittler
authors.forename: B K
authors.initials: BK
authors.lastname: Vogler
authors.forename: E
authors.initials: E
authors.lastname: Ernst
mesh_terms: D000529:Complementary Therapies; D006801:Humans; D008881:Migraine Disorders / Q000517:prevention & control*; D008517:Phytotherapy; D010946:Plants, Medicinal; D016032:Randomized Controlled Trials as Topic; D020903:Tanacetum parthenium / Q000627:therapeutic use*