title: Low-intensity exercise as a modifier of physical frailty in older adults.
abstract: OBJECTIVE
  To examine the effects of a 3-month low-intensity exercise program on physical frailty.
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  Regional tertiary-care hospital and academic medical center with an outpatient rehabilitation fitness center.
  
  
  METHODS
  Eighty-four physically frail older adults (mean age, 83 +/- 4 yrs).
  
  
  METHODS
  Three-month low-intensity supervised exercise (n = 48) versus unsupervised home-based flexibility activities (n = 36).
  
  
  METHODS
  Physical performance test, measures of balance, strength, flexibility, coordination, speed of reaction, peripheral sensation.
  
  
  RESULTS
  Significant improvement was made by the exercise group on our primary indicator of frailty, a physical performance test (PPT) (29 +/- 4 vs 31 +/- 4 out of a possible 36 points), as well as many of the risk factors previously identified as contributors to frailty; eg, reductions in flexibility, strength, gait speed, and poor balance. Although the home exercise control group showed increases in range of motion, the improvements in flexibility did not translate into improvements in physical performance capacity as assessed by the PPT.
  
  
  CONCLUSIONS
  Our results suggest that physical frailty is modifiable with a program of modest activities that can be performed by virtually all older adults. They also indicate that exercise programs consisting primarily of flexibility activities are not likely to reverse or attenuate physical frailty. Although results suggest that frailty is modifiable, it is not likely to be eliminated with exercise, and efforts should be directed toward preventing the condition.
authors.affiliation: Claude Pepper Older Adult Independence Center, Division of Geriatrics and Gerontology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: D R
authors.initials: DR
authors.lastname: Sinacore
authors.forename: A A
authors.initials: AA
authors.lastname: Ehsani
authors.forename: E F
authors.initials: EF
authors.lastname: Binder
authors.forename: J O
authors.initials: JO
authors.lastname: Holloszy
authors.forename: W M
authors.initials: WM
authors.lastname: Kohrt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005081:Exercise Therapy; D005260:Female; D016330:Frail Elderly; D006801:Humans; D008297:Male; D004856:Postural Balance; D016059:Range of Motion, Articular