Synthesis, characterization and bioactivity of a new VO2+/aspirin complex.
A new VO2+ complex with salicylic acid acetate (Aspirin) of formula C18H18Cl2O12V2 was synthesized and characterized. Its biological effects upon cell proliferation, differentiation and promotion of tyrosine protein phosphorylation have been tested in two lines of osteoblast-like cells in culture.
Etcheverry
S B
SB
Cátedra de Bioquímica Patológica, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina. etcheverry@nahuel.biol.unlp.edu.ar
Williams
P A
PA
Barrio
D A
DA
Sálice
V C
VC
Ferrer
E G
EG
Cortizo
A M
AM
D000818:Animals; D001241:Aspirin / Q000138:chemical synthesis* / Q000494:pharmacology; D015153:Blotting, Western; D001842:Bone and Bones / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D010006:Osteoblasts / Q000187:drug effects; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D014638:Vanadates / Q000138:chemical synthesis* / Q000494:pharmacology
D019000:Phosphotyrosine; D014638:Vanadates; D001241:Aspirin