Multipoint mapping of viability and segregation distorting loci using molecular markers.
In line-crossing experiments, deviations from Mendelian segregation ratios are usually observed for some markers. We hypothesize that these deviations are caused by one or more segregation-distorting loci (SDL) linked to the markers. We develop both a maximum-likelihood (ML) method and a Bayesian method to map SDL using molecular markers. The ML mapping is implemented via an EM algorithm and the Bayesian method is performed via the Markov chain Monte Carlo (MCMC). The Bayesian mapping is computationally more intensive than the ML mapping but can handle more complicated models such as multiple SDL and variable number of SDL. Both methods are applied to a set of simulated data and real data from a cross of two Scots pine trees.
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Department of Biology, University of Oulu, FIN-90401 Oulu, Finland. claus@genetics.ucr.edu
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D000483:Alleles; D001499:Bayes Theorem; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D020090:Chromosome Segregation / Q000235:genetics*; D003198:Computer Simulation; D003433:Crosses, Genetic; D005328:Fetal Viability / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D007178:Inbreeding; D016013:Likelihood Functions; D008540:Meiosis / Q000235:genetics; D008957:Models, Genetic; D016012:Poisson Distribution; D011237:Predictive Value of Tests; D014197:Trees / Q000235:genetics
D005819:Genetic Markers