Decrease of sexual receptivity by prolylendopeptidase inhibitor in female rats.
The effects of a prolylendopeptidase inhibitor, 1-[3-(2-indanylanylacetyl)-L-thioprolyl]pyrrolidine (Z-321), on lordosis behavior were investigated in estrogen and progesterone-treated ovariectomized rats. Females were orally administered 100, 200 or 300 mg/kg Z-321 or the vehicle (control). The mean lordosis quotient in the rats given 300 mg/kg Z-321 was lower than that in control group, but that in rats given 100 or 200 mg/kg Z-321 was not lower. Thus, Z-321 suppressed lordosis in estrogen and progesterone-treated ovariectomized rats. Peptide neurotransmitters, especially those containing proline, are thought to be involved in the inhibitory mechanisms for lordosis behavior.
Oosuka
I
I
Department of Basic Human Sciences, School of Human Sciences, Waseda University, Tokorozawa, Saitama, Japan.
Tanaka
Y
Y
Miura
N
N
Yamanouchi
K
K
D000818:Animals; D002766:Cholecystokinin / Q000502:physiology; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D011187:Posture; D000085822:Prolyl Oligopeptidases; D011480:Protease Inhibitors / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D014667:Vasopressins / Q000502:physiology
C106522:1-(3-(2-indanylacetyl)-L-thioprolyl)pyrrolidine; D011480:Protease Inhibitors; D011759:Pyrrolidines; D014667:Vasopressins; D002766:Cholecystokinin; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases