title: Multiple myeloma in cats: variable presentation with different immunoglobulin isotypes in two cats.
abstract: Multiple myeloma was diagnosed in two cats with monoclonal hyperglobulinemia, proteinuria, and plasma cell proliferations in bone marrow. An immunoglobulin G-producing myeloma occurred in the vertebral bone marrow of one cat, and twice responded to surgical reduction followed by a combination of local irradiation and chemotherapy. The cat's survival time was approximately 2 years. The other myeloma in a cat that presented with hypercalcemia and renal insufficiency involved visceral organs and produced a biclonal peak due to immunoglobulin A dimer formation on serum electrophoresis. This cat's tumor did not respond to chemotherapy.
authors.affiliation: Department of Pathobiology, University of Guelph, ON, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Bienzle
authors.forename: D C
authors.initials: DC
authors.lastname: Silverstein
authors.forename: K
authors.initials: K
authors.lastname: Chaffin
mesh_terms: D000818:Animals; D001707:Biopsy, Needle / Q000662:veterinary; D002371:Cat Diseases / Q000276:immunology / Q000473:pathology*; D002415:Cats; D003720:Densitometry / Q000662:veterinary; D004588:Electrophoresis, Cellulose Acetate / Q000662:veterinary; D005065:Euthanasia / Q000662:veterinary; D005260:Female; D007132:Immunoglobulin Isotypes / Q000032:analysis*; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000662:veterinary; D008297:Male; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
chemical_list: D007132:Immunoglobulin Isotypes