title: Patterns of recurrence in patients with squamous cell carcinoma of the vulva. A multicenter CTF Study.
abstract: BACKGROUND
  Invasive vulvar carcinoma is a rare disease with an incidence rate of 3-5% of all female genital neoplasms. The current study discusses the limited number of articles in the literature regarding the patterns of recurrence as well as the clinical outcome of patients with recurrent disease based on a consistent and consecutive series of cases.
  
  
  METHODS
  A common clinical chart focusing on the study of patterns of recurrence was used in five Italian gynecologic institutions with uniform criteria of surgical nomenclature, pathologic variables, and sites of recurrence. Between 1980-1994, 502 cases of primary invasive squamous carcinoma of the vulva were registered consecutively, treated, and considered for this multicentered study.
  
  
  RESULTS
  Of 502 patients, 187 (37.3%) developed a recurrence. Distribution of the recurrences by site was as follows: perineal, 53.4%; inguinal, 18.7%; pelvic, 5.7%; distant, 7.9%; and multiple, 14.2%. In a multivariate analysis, 3 characteristics appeared to be statistically correlated with the risk of recurrence: International Federation of Gynecology and Obstetrics Stage > II (P = 0.029), positive lymph nodes (P = 0.009), and vascular space invasion (P = 0.004). The 5-year survival rate was 60% for perineal recurrences, 27% for inguinal and pelvic recurrences, 15% for distant recurrences, and 14% for multiple recurrences.
  
  
  CONCLUSIONS
  In the current study the prognostic factors found to have statistical significance as prognostic factors for risk of recurrence were tumor dimension, lymph node involvement, and stromal and vascular space invasion. The presence of inguinal lymph node metastases was predictive of multiple and distant recurrences with a low rate of incidence of isolated perineal recurrence (27%) compared with negative lymph node cases (57.5%). Survival analysis of recurrent disease showed that the surgical resection of local recurrences may provide acceptable results (51% at 5 years). This observation may justify a follow-up program aimed at identifying those patients with early local recurrence suitable for radical resection.
authors.affiliation: Institute of Obstetrics and Gynecology, University of Padova, Padova, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Maggino
authors.forename: F
authors.initials: F
authors.lastname: Landoni
authors.forename: E
authors.initials: E
authors.lastname: Sartori
authors.forename: P
authors.initials: P
authors.lastname: Zola
authors.forename: A
authors.initials: A
authors.lastname: Gadducci
authors.forename: C
authors.initials: C
authors.lastname: Alessi
authors.forename: M
authors.initials: M
authors.lastname: Soldà
authors.forename: S
authors.initials: S
authors.lastname: Coscio
authors.forename: G
authors.initials: G
authors.lastname: Spinetti
authors.forename: A
authors.initials: A
authors.lastname: Maneo
authors.forename: A
authors.initials: A
authors.lastname: Ferrero
authors.forename: G
authors.initials: G
authors.lastname: Konishi De Toffoli
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery