title: Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.
abstract: Although the biochemistry of triglyceride synthesis has been studied for decades, an understanding of the molecular processes involved has been lacking. The recent cloning of a gene encoding acyl coenzyme A : diacylglycerol acyltransferase, an enzyme that catalyses the final step in triglyceride synthesis, has opened this area to molecular investigation and has begun to provide new insights into triglyceride metabolism.
authors.affiliation: Gladstone Institutes of Cardiovascular Disease, San Francisco, CA 94141-9100, USA. bfarese@gladstone.ucsf.edu
authors.forename: R V
authors.initials: RV
authors.lastname: Farese
authors.forename: S
authors.initials: S
authors.lastname: Cases
authors.forename: S J
authors.initials: SJ
authors.lastname: Smith
mesh_terms: D000217:Acyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D003001:Cloning, Molecular; D018076:DNA, Complementary; D051048:Diacylglycerol O-Acyltransferase; D006801:Humans; D014280:Triglycerides / Q000096:biosynthesis*
chemical_list: D018076:DNA, Complementary; D014280:Triglycerides; D000217:Acyltransferases; D051048:Diacylglycerol O-Acyltransferase