title: Association of D2 dopamine receptor and alcohol dehydrogenase 2 genes with Polynesian alcoholics.
abstract: Alleles of the D2 dopamine receptor (DRD2) and the alcohol dehydrogenase 2 (ADH2) genes were determined in 69 French Polynesian alcoholic patients and 57 controls matched for racial origin. Three racial groups were studied: pure Polynesians (PP), Polynesians mixed with Caucasian (PCA) ancestry and Polynesians mixed with Chinese (PCH) ancestry. DRD2 A1 allele frequencies in the alcoholics compared to their controls in these groups were: PP,.26 vs.32 (P =. 69); PCA,.44 vs.35 (P =.46); PCH,.40 vs 0.39 (P =.88). ADH2 1 allele frequencies in alcoholics compared to their controls groups were: PP, .56 vs.62 (P =.66); PCA,.75 vs.56 (P =.09); PCH,.78 vs.32 (P =.009). In the PCA group, the combination of the DRD2 A1 genotypes and the ADH2 1 homozygotes was strongly associated with alcoholism (P =. 0027). This preliminary study shows the importance of ascertaining racial ancestry in molecular genetic association studies. Moreover, it suggests that a combination of genes are involved in susceptibility to the development of alcoholism.
authors.affiliation: Service de Psychiatrie Adulte, Hopital Vaiami, Papeete Tahiti, Polynésie Fran"caise.
authors.forename: S
authors.initials: S
authors.lastname: Amadéo
authors.forename: E P
authors.initials: EP
authors.lastname: Noble
authors.forename: M L
authors.initials: ML
authors.lastname: Fourcade-Amadéo
authors.forename: C
authors.initials: C
authors.lastname: Tetaria
authors.forename: M F
authors.initials: MF
authors.lastname: Brugiroux
authors.forename: L
authors.initials: L
authors.lastname: Nicolas
authors.forename: X
authors.initials: X
authors.lastname: Deparis
authors.forename: A
authors.initials: A
authors.lastname: Elbaz
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Ritchie
authors.forename: P V
authors.initials: PV
authors.lastname: Martin
authors.forename: J
authors.initials: J
authors.lastname: Mallet
mesh_terms: D000328:Adult; D000426:Alcohol Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000437:Alcoholism / Q000201:enzymology / Q000208:ethnology* / Q000235:genetics*; D000483:Alleles; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D011114:Polynesia; D017448:Receptors, Dopamine D2 / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2; D000426:Alcohol Dehydrogenase