title: Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark.
abstract: The anti-inflammatory profile of the aqueous extract of Bridelia ferruginea stem bark was investigated using both in vivo and in vitro models. The extract exhibited strong topical anti-inflammatory effect shown as inhibition of croton oil-induced ear oedema in mice, and reduced hind-paw swelling and growth retardation in the adjuvant-induced arthritis model in rats, following oral administration at 10, 20, 40 or 80 mg/kg. The extract (10-80 mg/kg, p.o.) caused an inhibition of increase in vascular permeability in both cyclophosphamide-induced haemorrhagic cystitis and acetic acid-induced vascular permeability in rats and mice, respectively. B. ferruginea produced stabilization of erythrocytes exposed to heat and stress-induced lysis. Antipyretic and analgesic properties of the extract were also observed.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria. mailbox@ibadan.skannet.com
authors.forename: O A
authors.initials: OA
authors.lastname: Olajide
authors.forename: J M
authors.initials: JM
authors.lastname: Makinde
authors.forename: D T
authors.initials: DT
authors.lastname: Okpako
authors.forename: S O
authors.initials: SO
authors.lastname: Awe
mesh_terms: D019342:Acetic Acid; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating; D001169:Arthritis, Experimental / Q000188:drug therapy; D003520:Cyclophosphamide; D003556:Cystitis / Q000139:chemically induced / Q000517:prevention & control; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D004912:Erythrocytes / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D019441:Plant Epidermis / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D018906:Antineoplastic Agents, Alkylating; D010936:Plant Extracts; D003520:Cyclophosphamide; D019342:Acetic Acid