title: Review article: agents affecting gall-bladder motility--role in treatment and prevention of gallstones.
abstract: Various agents may either enhance or impair post-prandial gall-bladder motility, and they are identified in this review. When studying the impact of medication on gall-bladder motility, the effects on interdigestive gall-bladder and intestinal motility should also be taken into account. Patients at high risk of gallstone disease, and patients who are treated chronically with gall-bladder motility inhibiting drugs, may benefit from improved gall-bladder motility using a prokinetic agent. However, there are no long-term studies to prove that such a strategy prevents gallstone formation.
authors.affiliation: Gastrointestinal Research Unit, University Medical Center, Utrecht, The Netherlands. k.j.vanerpecum@digd.azu.nl
authors.forename: K J
authors.initials: KJ
authors.lastname: van Erpecum
authors.forename: N G
authors.initials: NG
authors.lastname: Venneman
authors.forename: P
authors.initials: P
authors.lastname: Portincasa
authors.forename: G P
authors.initials: GP
authors.lastname: Vanberge-Henegouwen
mesh_terms: D002769:Cholelithiasis / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control*; D004917:Erythromycin / Q000627:therapeutic use; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology*; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D005769:Gastrointestinal Motility; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D019518:Postprandial Period
chemical_list: D005765:Gastrointestinal Agents; D004917:Erythromycin