New antineoplastic prenylhydroquinones. Synthesis and evaluation.
Several prenylhydroquinones have been prepared through Diels-Alder condensation, further functionalized or degraded chemically and then evaluated for their cytotoxic activity against some neoplastic cultured cell lines. A number of them have shown IC50 values under the microM level.
Molinari
A
A
Instituto de Química, Universidad Católica de Valparaíso, Chile.
Oliva
A
A
Aguilera
N
N
Miguel del Corral
J M
JM
Castro
M A
MA
Gordaliza
M
M
García-Grávalos
M D
MD
San Feliciano
A
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006873:Hydroquinones