title: The physiology and the pathophysiology of the gastric accommodation reflex in man.
abstract: Summarizing the previous sections, we have demonstrated that the gastric accommodation reflex in man involves the release of serotonin and the activation of a nitrergic motor neuron. We observed that almost half of the patients with functional dyspepsia have an impaired accommodation reflex, and this is associated with early satiety and weight loss. Drug-induced inhibition of the accommodation reflex is able to induce early satiety in healthy subjects. Administration of the anti-migraine drug sumatriptan, an agonist at 5-HT1P receptors on gastric myenteric neurons, causes a relaxation of the proximal stomach in man through a nitrergic pathway. Pretreatment with sumatriptan is able to restore impaired accommodation and to improve early satiety in patients with functional dyspepsia. We conclude from these data that fundus-relaxing drugs may have a therapeutic potential in functional dyspepsia, and we hypothesize that fundus-contracting drugs may have therapeutic potential in the treatment of obesity.
authors.affiliation: Department of Internal Medicine, University Hospital Gasthuisberg, University of Leuven.
authors.forename: J
authors.initials: J
authors.lastname: Tack
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001066:Appetite / Q000502:physiology; D004415:Dyspepsia / Q000503:physiopathology*; D005746:Gastric Emptying; D006801:Humans; D009119:Muscle Contraction; D012018:Reflex / Q000502:physiology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013270:Stomach / Q000502:physiology* / Q000503:physiopathology; D018170:Sumatriptan / Q000494:pharmacology
chemical_list: D017366:Serotonin Receptor Agonists; D018170:Sumatriptan