[Regulation of hyaluronidase inhibition through its chemical modification].
The modification of hyaluronidase by aldehydodextran regulates inhibition of the enzyme by heparin. A 70-90% modification of the surface amino groups of hyaluronidase results in sharp conformational changes and a substantial decrease of its inhibition by heparin, whereas hyaluronidase derivatives with a modification degree of 96-100% are practically uninhibited.
Maksimenko
A V
AV
Institute of Experimental Cardiology, Russian Cardiologycal Research Center, Moscow, Russia. cclibr@transts.ru
Petrova
M L
ML
Tishchenlo
E G
EG
Shchechilina
Iu V
IuV
D003911:Dextrans; D004789:Enzyme Activation; D005343:Fibrinolytic Agents / Q000378:metabolism* / Q000494:pharmacology; D006493:Heparin / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
D003911:Dextrans; D005343:Fibrinolytic Agents; D006493:Heparin; D006821:Hyaluronoglucosaminidase