Finite-temperature sequence alignment.
We develop a statistical theory of probabilistic sequence alignments derived from a 'thermodynamic' partition function at finite temperature. Such alignments are a generalization of those obtained from information-theoretic approaches. Finite-temperature statistics can be used to characterize the significance of an alignment and the reliability of its single element pairs.
Kschischo
M
M
Max-Planck Institut für Kolloid- und Grenzflächenforschung, Potsdam, Germany.
Lässig
M
M
D000465:Algorithms; D003198:Computer Simulation; D019277:Entropy; D007257:Information Theory; D008390:Markov Chains; D015233:Models, Statistical; D016415:Sequence Alignment / Q000379:methods* / Q000706:statistics & numerical data; D013696:Temperature; D013816:Thermodynamics