Skin hemodynamics during change from supine to lateral position.
The purpose of this study was to identify the skin hemodynamics during the position change from supine to lateral in patients with neurodegenerative diseases. The participants were 19 patients with neurodegenerative diseases and 12 healthy volunteers. The alteration in the total concentration of oxyhemoglobin and deoxyhemoglobin, indicative of change in blood volume, was measured in the skin of the left flank by using a portable noninvasive tissue oxygen monitor by near-infrared spectroscopy. The positions were changed from the left and right lateral with a return to the supine between each procedure. In healthy volunteers, total hemoglobin concentration (skin blood volume) increased when the position changed from supine to left lateral and decreased when changed from supine to right lateral. The decreased skin blood volume gradually recovered after a change from the supine to the right lateral position in healthy volunteers. However, it did not recover in three sporadic olivopontocerebellar atrophy (OPCA) patients with marked autonomic dysfunction and one Parkinsonian patient with severe orthostatic hypotension. Our study identified that the intracutaneous blood was changing dynamically during the position change from supine to lateral and was regulated by autonomic nerve function.
Kusano
E
E
Basic Laboratory Sciences, School of Allied Health Sciences, Faculty of Medicine, Osaka University, Japan.
Yorifuji
S
S
Okuno
M
M
Nakanishi
F
F
Imaoka
H
H
Matsuo
Y
Y
Abe
K
K
Hayakawa
K
K
D017776:Autonomic Pathways / Q000503:physiopathology; D001510:Bed Rest / Q000009:adverse effects / Q000451:nursing; D001810:Blood Volume / Q000502:physiology; D016022:Case-Control Studies; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000451:nursing / Q000503:physiopathology*; D009730:Nursing Assessment; D011187:Posture / Q000502:physiology*; D012867:Skin / Q000098:blood supply* / Q000294:innervation; D019265:Spectroscopy, Near-Infrared; D016683:Supine Position / Q000502:physiology*