title: Postbypass pulmonary artery pressure influences respiratory system compliance after ventricular septal defect closure.
abstract: It is reported that surgical correction of left-to-right shunt improves respiratory function in paediatric cardiac patients. However, such correction sometimes does not result in an improvement of respiratory compliance. The purpose of this study was to look for factors determining changes in respiratory system compliance (Crs) in patients who underwent closure of ventricular septal defect (VSD closure). In a prospective study, 17 children (< 10 kg) who underwent VSD closure were enrolled. They were divided into two groups, according to postbypass mean pulmonary artery pressure (mPAP). The patients were allocated to Group C if mPAP was < or = 18 mmHg (n=12) and to Group PH if > 18 mmHg (n=5). We compared the ratio of postoperative Crs to preoperative Crs (Cpost/Cpre) between the groups. A multiple occlusion technique was used to measure Crs. The Cpost/Cpre in group C was larger than that in group PH (1.11+/-0.17 vs. 0.81+/-0.12, P<0.01). There was a correlation between postbypass mPAP and Cpost/Cpre (r(s)=0.49, P<0.05), but no correlation was noted between preoperative mPAP, Qp/Qs or Rp/Rs and Cpost/Cpre. We concluded that high postbypass mPAP was associated with a perioperative decrease in Crs after VSD closure.
authors.affiliation: Department of Anesthesiology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Kinouchi
authors.forename: K
authors.initials: K
authors.lastname: Fukumitsu
authors.forename: H
authors.initials: H
authors.lastname: Kishimoto
authors.forename: S
authors.initials: S
authors.lastname: Kitamura
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D002315:Cardiopulmonary Bypass; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology; D007223:Infant; D008170:Lung Compliance / Q000502:physiology; D011312:Pressure; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000502:physiology*; D011652:Pulmonary Circulation / Q000502:physiology; D012123:Pulmonary Ventilation / Q000502:physiology; D012119:Respiration; D014655:Vascular Resistance / Q000502:physiology