Processing glucosidase inhibition by 1-azafagomine.
Natural azasugars have the ring oxygen substituted by nitrogen. They show potent inhibitory activity against glycosidases. The effect of substituting the ring carbon with nitrogen was examined with 1-azafagomine. 1-Azafagomine exhibited similar activity against processing glucosidase to that of fagomine.
Muroi
M
M
Animal and Cellular Systems Laboratory, RIKEN (The Institute of Physical and Chemical Research), Wako-shi, Saitama, Japan.
Ando
O
O
Bols
M
M
Takatsuki
A
A
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005959:Glucosidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005960:Glucosides / Q000378:metabolism; D006801:Humans; D050112:Imino Pyranoses; D007212:Indolizines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D011499:Protein Processing, Post-Translational; D013379:Substrate Specificity
C414749:1-azafagomine; D004791:Enzyme Inhibitors; D005960:Glucosides; D050112:Imino Pyranoses; D007212:Indolizines; D010880:Piperidines; D017485:1-Deoxynojirimycin; C105643:fagomine; D005959:Glucosidases