UV-A and PUV-A action on Sendai virus HN glycoprotein.
The UV-A and PUV-A treatments were applied on the Sendai virus and the changes of the biological properties of HN surface glycoprotein were monitorized. Under the UV-A action the HA and NA activities are inhibited in a dose-correlated way. When the irradiation was done in the presence of a photoreagent (8-MOP) the HA activity remained unchanged, but the enzymic activity was affected. The possible mechanisms of these inhibition processes are discussed.
Obeadă
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Stefan S. Nicolau Institute of Virology, Bucharest.
Pleşa
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Repanovici
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D004307:Dose-Response Relationship, Radiation; D015707:HN Protein / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D006386:Hemagglutination Tests; D008730:Methoxsalen / Q000494:pharmacology; D009439:Neuraminidase / Q000378:metabolism; D011701:PUVA Therapy; D018108:Respirovirus / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
D015707:HN Protein; D009439:Neuraminidase; D008730:Methoxsalen