title: Transperineal magnetic resonance image guided prostate biopsy.
abstract: OBJECTIVE
  We report the findings of a transperineal magnetic resonance image (MRI) guided biopsy of the prostate in a man with increasing prostate specific antigen who was not a candidate for a transrectal ultrasound guided biopsy.
  
  
  METHODS
  Using an open configuration 0.5 Tesla MRI scanner and pelvic coil, a random sextant sample was obtained under real time MRI guidance from the peripheral zone of the prostate gland as well as a single core from each MRI defined lesion. The patient had previously undergone proctocolectomy for ulcerative colitis and, therefore, was not a candidate for transrectal ultrasound guided biopsy. Prior attempts to make the diagnosis of prostate cancer using a transurethral approach were unsuccessful.
  
  
  RESULTS
  The random sextant samples contained benign prostatic hyperplasia, whereas Gleason grade 3 + 3 = 6 adenocarcinoma was confirmed in 15% and 25% of the 2 cores obtained from the MRI targeted specimens of 2 defined lesions. The procedure was well tolerated by the patient.
  
  
  CONCLUSIONS
  Transperineal MRI guided biopsy is a new technique that may be useful in detecting prostate cancer in men with increasing prostate specific antigen who are not candidates for transrectal ultrasound guided biopsy.
authors.affiliation: Departments of Radiation Oncology, Radiology, Pathology and Urology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: A V
authors.initials: AV
authors.lastname: D'Amico
authors.forename: C M
authors.initials: CM
authors.lastname: Tempany
authors.forename: R
authors.initials: R
authors.lastname: Cormack
authors.forename: N
authors.initials: N
authors.lastname: Hata
authors.forename: M
authors.initials: M
authors.lastname: Jinzaki
authors.forename: K
authors.initials: K
authors.lastname: Tuncali
authors.forename: M
authors.initials: M
authors.lastname: Weinstein
authors.forename: J P
authors.initials: JP
authors.lastname: Richie
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D001706:Biopsy / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010537:Peritoneum; D011467:Prostate / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*