Late complications of tissue glues in aortic surgery.
BACKGROUND
Tissue glues are used in cardiothoracic surgery as an adjunct to operative procedures where tissues are frail, as in aortic dissection, or where added hemostasis is required. This study was undertaken to review the use of tissue glue in our institution over a 5.5-year period. The aim of the study was to identify any potentially glue-related complications.


METHODS
A review of tissue glue use for the period from January 1993 to September 1998 was performed and pre-, intra-, and postoperative parameters were collected. After some unusual surgical findings, of special interest was a range of pathology found at late reoperation.


RESULTS
A total of 67 cases of tissue glue use were identified, with the majority of operations for type A dissection (76%). There were two intraoperative deaths. Twenty-seven of 65 patients (41%) required 29 further open chest operations; of these, 17 were for acute problems of bleeding or tamponade. Twelve patients (18%) underwent late reoperations months to years later. Nine of these patients, concentrated in two operative groups (7 patients with aortic valve resuspension and 2 patients who had undergone "switch" operations for transposition of great vessels), displayed complications related to the application of gelatin-resorcinol-formaldehyde (GRF) tissue glue.


CONCLUSIONS
Indications for tissue glues in cardiothoracic surgery must be carefully considered. We have reviewed our use of some tissue glues in acute type A aortic dissections and in pediatric cardiac patients and have discontinued the use of GRF glues because of unsatisfactory long-term complications.
Bingley
J A
JA
Department of Cardiothoracic Surgery, The Prince Charles Hospital, Chermside, Queensland, Australia. j.bingley@uq.net.au
Gardner
M A
MA
Stafford
E G
EG
Mau
T K
TK
Pohlner
P G
PG
Tam
R K
RK
Jalali
H
H
Tesar
P J
PJ
O'Brien
M F
MF
D000784:Aortic Dissection / Q000473:pathology / Q000601:surgery*; D001013:Aorta, Thoracic / Q000473:pathology / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000473:pathology / Q000601:surgery*; D004338:Drug Combinations; D005260:Female; D005557:Formaldehyde / Q000009:adverse effects / Q000627:therapeutic use; D005780:Gelatin / Q000009:adverse effects / Q000627:therapeutic use; D006488:Hemostasis, Surgical; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D012008:Recurrence; D012086:Reoperation; D012118:Resorcinols / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D014014:Tissue Adhesives / Q000009:adverse effects* / Q000627:therapeutic use
D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin