Beta-cyclodextrin(beta-CD) influence on the biotoxicities of substituted benzene compounds and pesticide intermediates.
The acute toxicities of 19 substituted benzene compounds and intermediates of pesticides to Photobacterium phosphoreum in beta-CD aqueous solution (5 g/L) were studied and compared with those in water through luminescent bacteria toxicity test, and 15min-EC50 values were obtained. The presence of beta-CD significantly reduce biotoxicities of the low-polarity compounds, while for the higher-polarity compounds, such effect was slight. The differences of biotoxicities were correlated with Log10Kow (octanol/water partition coefficients). A significant linear relationship was obtained with some abnormal data picked out. Some explanations concerning molecular structure of chemicals as well as beta-CD were given for the relationship.
Wen-Lu
S
S
Center for Computation and Analysis, China Pharmaceutical University, Nanjing, PR China.
Qing-Guo
H
H
Lian-Sheng
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W
D001555:Benzene Derivatives / Q000032:analysis / Q000633:toxicity*; D003505:Cyclodextrins / Q000032:analysis / Q000633:toxicity*; D010575:Pesticides / Q000032:analysis / Q000633:toxicity*; D010776:Photobacterium / Q000187:drug effects*; D012044:Regression Analysis; D013056:Spectrophotometry, Ultraviolet; D047392:beta-Cyclodextrins
D001555:Benzene Derivatives; D003505:Cyclodextrins; D010575:Pesticides; D047392:beta-Cyclodextrins; C031215:betadex