Isolation of an attenuated myxoma virus field strain that can confer protection against myxomatosis on contacts of vaccinates.
Twenty MV strains obtained from a survey of field strains currently circulating throughout Spain were analyzed for their virulence and horizontal spreading among rabbits by contact transmission. A virus strain with suitable characteristics to be used as a potential vaccine against myxomatosis in wild rabbit populations was selected. Following inoculation, the selected MV strain elicited high levels of MV specific antibodies and induced protection of rabbits against a virulent MV challenge. Furthermore, the attenuated MV was transmitted to 9 out of 16 uninoculated rabbits by contact, inducing protection against myxomatosis.
Bárcena
J
J
Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain.
Pagès-Manté
A
A
March
R
R
Morales
M
M
Ramírez
M A
MA
Sánchez-Vizcaíno
J M
JM
Torres
J M
JM
D000818:Animals; D007114:Immunization; D009233:Myxoma virus / Q000276:immunology* / Q000472:pathogenicity; D011213:Poxviridae Infections / Q000517:prevention & control* / Q000635:transmission; D011817:Rabbits; D014412:Tumor Virus Infections / Q000517:prevention & control* / Q000635:transmission; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014774:Virulence
D014613:Vaccines, Attenuated; D014765:Viral Vaccines