title: Impaired glucose tolerance (IGT) is not associated with disturbed homocysteine metabolism.
abstract: Elevated plasma total homocysteine (tHcy) has been suggested to be an additional risk factor for cardiovascular disease in subjects with impaired glucose tolerance (IGT) and Type 2 diabetes (T2D). In order to investigate whether an insulin resistant/chronic hyperinsulinemic situation in male diabetic and prediabetic subjects directly influences the tHcy metabolism, fasting tHcy and post-methionine load tHcy plasma levels (PML-tHcy) were determined in 15 men with IGT, 13 men with newly diagnosed T2D, and 16 normoglycemic controls (NGT). Fasting tHcy (IGT, 13.1 +/- 4.6; T2D, 12.8 +/- 4.0; NGT, 10.7 +/- 4.4 micromol/L) and PML-tHcy (IGT, 46.5 +/-17.39; T2D, 41.1 +/- 6.8; NGT, 38.0 +/- 9.7 micromol/L) showed no differences between the groups. Fasting tHcy and PML-tHcy correlated with fasting proinsulin (r = 0.395, p < 0.05; r = 0.386, p< 0.05) and creatinine (r = 0.489, p < 0.01; r = 0.339, p < 0.05), resp. Multiple regression analysis showed only a relationship between fasting tHcy and creatinine. No relationships have been found between fasting tHcy and PML-tHcy, resp., and indicators of an insulin resistant state, e.g., insulin and proinsulin, as well as serum cobalamin and folate concentrations. In conclusion, our data suggest that the degree of glucose intolerance has no direct impact on the metabolism of homocysteine. However, tHcy levels tend to be elevated with the development of nephropathy, indicating an association between tHcy and renal function in these subjects.
authors.affiliation: Institute and Policlinic of Clinical Metabolic Research, Medical Faculty Carl Gustav Carus, Technical University Dresden, Federal Republic of Germany.
authors.forename: A
authors.initials: A
authors.lastname: Pixa
authors.forename: J
authors.initials: J
authors.lastname: Pietzsch
authors.forename: U
authors.initials: U
authors.lastname: Julius
authors.forename: M
authors.initials: M
authors.lastname: Menschikowski
authors.forename: M
authors.initials: M
authors.lastname: Hanefeld
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood; D003404:Creatinine / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008715:Methionine / Q000494:pharmacology; D008875:Middle Aged; D011384:Proinsulin / Q000097:blood; D012307:Risk Factors; D013997:Time Factors; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D001786:Blood Glucose; D007328:Insulin; D006710:Homocysteine; D011384:Proinsulin; D005492:Folic Acid; D008715:Methionine; D003404:Creatinine; D014805:Vitamin B 12