[The systemic response of antioxidant enzymes to the oxidative stress induced by irradiation at low doses].
As a result of total chronic gamma irradiation of mice (137Cs, 0.6 cGy/day, 9 days) the functioning of superoxide generation and utilisation systems in liver were disturbed. The regulatory links between the activities of superoxide dismutase and glutathione peroxidase are found to be maintained. Postradiation effects were more expressed for a total dose of 1.2 cGy than for a dose of 5.4 cGy, providing support for the hypothesis of delayed reparation as a reason of harmful action of low-dose irradiation.
Vartanian
L S
LS
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow. efrem@online.ru
Gurevich
S M
SM
Kozachenko
A I
AI
Nagler
L G
LG
Lozovskaia
E L
EL
Burlakova
E B
EB
D000818:Animals; D003600:Cytosol / Q000201:enzymology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D005979:Glutathione Peroxidase / Q000528:radiation effects*; D008099:Liver / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008930:Mitochondria, Liver / Q000201:enzymology / Q000528:radiation effects; D018384:Oxidative Stress / Q000528:radiation effects*; D013482:Superoxide Dismutase / Q000528:radiation effects*; D013997:Time Factors; D014916:Whole-Body Irradiation
D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase