Anti-inflammatory activities of Trichilia glabra aqueous leaf extract.
Trichilia glabra L. aqueous leaf extract exerted a significant antiinflammatory effect 'in vivo' in the zymosan-induced inflammation model. The extract impaired the 'in vitro' activities of polymorphonuclear leukocytes and complement, components of mouse immune system closely related to the inflammatory response induced by zymosan. In particular, a significant reduction in the phagocytic capability and respiratory burst response of mouse polymorphonuclear leukocytes together with an inhibition in the hemolytic activity of mouse complement was observed.
Benencia
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Laboratory of Virology, Faculty of Science, University of Buenos Aires, Pabellón II, Piso 4, Ciudad Universitaria, (1428) Nuñez, Buenos Aires, Argentina. fbenen@qb.fcen.uba.ar
Courrèges
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MC
Coulombié
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D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003169:Complement Inactivator Proteins / Q000494:pharmacology; D003170:Complement Pathway, Alternative / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects; D009580:Nitroblue Tetrazolium; D010587:Phagocytosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D015054:Zymosan
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003169:Complement Inactivator Proteins; D010936:Plant Extracts; D009580:Nitroblue Tetrazolium; D015054:Zymosan