Mammalian chitinase-like proteins.
Mammals express genes coding for proteins that show significant similarity to chitinases of family 18 glycosyl hydrolases. These chitinase-like proteins have no chitinase activity due to changes in critical residues in the putative active center. One of these is oviductin, a high molecular weight glycoprotein most likely involved in fertilization and protection of the tubal epithelium owing to its mucin character. Another is YKL-40 (HCgp39) produced in association with tissue remodeling. Such proteins could have a general function in morphogenesis.
Bleau
G
G
Département d'Obstétrique-Gynécologie, Centre Hospitalier de l'Université de Montréal, Hôpital Saint-Luc, Québec, Canada.
Massicotte
F
F
Merlen
Y
Y
Boisvert
C
C
D000595:Amino Acid Sequence; D000818:Animals; D002688:Chitinases / Q000737:chemistry*; D017124:Conserved Sequence; D006026:Glycoside Hydrolases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008322:Mammals; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012697:Serine Endopeptidases / Q000737:chemistry
D006026:Glycoside Hydrolases; D002688:Chitinases; D012697:Serine Endopeptidases; C074599:oviductin