Seasonal variation in heart rate variability in asthmatic children.
Asthma is a "seasonal disease" with symptoms either aggravated by environmental changes during specific seasons or prevalent at certain times of the year for other reasons. We examined whether the heart rate variability (HRV) of asthmatic children changes by season. The HRV during a portion of one night (00:00-04:00) and day (12:00-16:00) and the entire 24h period (00:00-24:00) during each of the four seasons was analyzed. The data of 95 children with asthma and 106 healthy children, as controls, were assessed. In children with asthma during the 24h period, seasonal variation in the low-frequency (LF) band (0.04-0.15 Hz) and the high-frequency (HF) band (0.15-0.4 Hz) were detected (HF: F=6.81, p=.0003; LF: F=4.18, p= .008). The HF value in the summer was significantly higher than in autumn and spring (Scheffe test: autumn vs. summer, s = 4.46, p < .001: spring vs. summer, s = 2.86, p < .05), while the LF value in autumn was significantly lower than in summer (s = 3.42, p < .01). In the control group, no seasonal variation in HF, LF, or LF/HF was detected. The findings infer the HRV, a surrogate measure of autonomic nervous system function, of asthmatic children is more susceptible to seasonal changes brought about by either endogenous annual rhythms or environmental weather phenomena.
Kazuma
N
N
Department of Pediatrics, Tokyo Women's Medical College, Daini Hospital, Japan.
Otsuka
K
K
Miyakawa
M
M
Shirase
E
E
Matsuoka
I
I
Murata
M
M
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015716:Electrocardiography, Ambulatory; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010507:Periodicity; D012621:Seasons; D013806:Theophylline / Q000627:therapeutic use; D014887:Weather
D001993:Bronchodilator Agents; D013806:Theophylline