IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation and biological activities.
A novel bioactive macrolide, IB-96212 has been isolated from the fermentation broth of a marine actinomycete, L-25-ES25-008. The strain belongs to the genus Micromonospora. The macrolide showed a very strong cytotoxic activity against P-388, and lower but significant activity against A-549, HT-29, and MEL-28 cell lines. We describe the isolation, taxonomy and fermentation of the producing strain as well as the isolation of IB-96212.
Fernández-Chimeno
R I
RI
Drug Discovery Division, PharmaMar, SA La Calera, Madrid, Spain.
Cañedo
L
L
Espliego
F
F
Grávalos
D
D
De La Calle
F
F
Fernández-Puentes
J L
JL
Romero
F
F
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000378:metabolism* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; C411677:IB 96212; D018942:Macrolides