title: The 5S rRNA genes in Macaca fascicularis are organized in two large tandem repeats.
abstract: The 5S rRNA genes in Macaca fascicularis are organized in tandem repeats which are unusually large and complex. The tandem repeats consist of a 7.3 kb DNA fragment with two 5S rRNA genes linked to a 4.3 kb fragment with one gene. The total number of genes in the repeats is 50-100 per haploid genome. The 5S rDNA has an external promoter, the D box, in the same position relative to transcription start as the human gene but is transcribed less efficiently than a human 5S rRNA gene in a HeLa cell extract.
authors.affiliation: Biochemistry Laboratory B, Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK-2200 N, Copenhagen, Denmark.
authors.forename: L R
authors.initials: LR
authors.lastname: Jensen
authors.forename: S
authors.initials: S
authors.lastname: Frederiksen
mesh_terms: D000818:Animals; D001483:Base Sequence; D004275:DNA, Ribosomal / Q000032:analysis; D016678:Genome; D006801:Humans; D008252:Macaca fascicularis; D008969:Molecular Sequence Data; D012341:RNA, Ribosomal, 5S / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D020080:Tandem Repeat Sequences / Q000235:genetics*
chemical_list: D004275:DNA, Ribosomal; D012341:RNA, Ribosomal, 5S