title: Influenza in three patients with human immunodeficiency virus infection.
abstract: Three Japanese outpatients with human immunodeficiency virus (HIV) infection on anti-retroviral therapy showed evidence of influenza in January 1999. CD4+ T cell counts of these patients prior to the diagnosis of influenza were 72, 248, and 152/mm3, and HIV RNA levels were 19,953, 1,259, and 1,585 copies/ml, respectively. Fever continued 4 to 5 days with no severe complications. One patient showed post-influenzal bronchitis which was effectively treated by antibiotics. None of these patients showed increased serum HIV RNA levels during and after influenza, however, in one patient, a transient reduction of CD4+ and CD8+ cells was seen during the active phase of influenza. Although symptoms of influenza in HIV carriers are generally mild and similar to those in healthy adults, careful follow-up is needed as symptoms of influenza in some HIV-infected patients can be prolonged and serious.
authors.affiliation: Department of General Medicine, Kyushu University Hospital, Fukuoka.
authors.forename: S
authors.initials: S
authors.lastname: Nabeshima
authors.forename: I
authors.initials: I
authors.lastname: Ariyama
authors.forename: Y
authors.initials: Y
authors.lastname: Chong
authors.forename: K
authors.initials: K
authors.lastname: Hirotsu
authors.forename: K
authors.initials: K
authors.lastname: Kakuda
authors.forename: J
authors.initials: J
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Kashiwagi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D009980:Influenza A virus; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000209:etiology* / Q000276:immunology; D018655:Lymphocyte Count; D008297:Male; D012367:RNA, Viral / Q000097:blood
chemical_list: D007252:Influenza Vaccines; D012367:RNA, Viral