[Protective effect of benznidazole against parasite reactivation in patients chronically infected with Trypanosoma cruzi and treated with corticoids for associated diseases].
Patients in the chronic phase of Chagas' disease and receiving corticoid because of concommitant diseases were treated with benznidazole, which was initiated at the same time of the use of corticoid in a group of 12 patients or 15 days afterwards in 6 patients. It has been proved in another paper that in the chronic phase of Chagas' disease corticoid use is associated with increased parasitemia, as evaluated by xenodiagnosis. In this study benznidazole use prevented this increase, and we suggest that in immunocompromised patients with chronic Chagas' disease the use of this drug could be useful.
Rassi
A
A
Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Goiás, Brasil.
Amato Neto
V
V
de Siqueira
A F
AF
Ferriolli Filho
F
F
Amato
V S
VS
Rassi Júnior
A
A
D000293:Adolescent; D000328:Adult; D000818:Animals; D014355:Chagas Disease / Q000150:complications / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use*; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014345:Trypanosoma / Q000187:drug effects* / Q000254:growth & development
D005938:Glucocorticoids; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole