title: The influence of impaired wound healing on the tissue reaction to percutaneous devices using titanium fiber mesh anchorage.
abstract: The objective of this investigation was to study the influence of impaired wound healing on the soft-tissue response to percutaneous devices using titanium fiber mesh anchorage. For this reason, diabetes mellitus was induced in rabbits with alloxan. Untreated rabbits were used as controls. Two implant types were inserted subcutaneously: two-stage percutaneous devices as well as separate titanium fiber mesh sheets. The soft-tissue response to both implants was assessed by clinical, histologic, and histomorphometric evaluation. Clinically, we observed a higher number of infectious complications around percutaneous implants in diabetic animals. Histologic and histomorphometric analyses revealed that severe diabetes effected matrix maturation and delayed neovascularization (p<0.05). We also observed higher numbers of inflammatory cells in the mesh porosity of percutaneous implants in severely diabetic animals (p = 0.09). Our results indicate that severe, uncontrolled diabetes negatively influences the maturity and neovascularization of connective tissue inside the fiber mesh porosity. The higher number of infectious complications in diabetic animals suggests that the presence of impaired healing conditions facilitates infection around skin penetrating devices.
authors.affiliation: Department of Biomaterials, University of Nijmegen, Nijmegen, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Gerritsen
authors.forename: J A
authors.initials: JA
authors.lastname: Lutterman
authors.forename: J A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004864:Equipment and Supplies; D011817:Rabbits; D014025:Titanium; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D014025:Titanium