Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.
A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity.
Obi
K
K
Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd, Tochigi-ken, Japan.
Uda
J
J
Iwase
K
K
Sugimoto
O
O
Ebisu
H
H
Matsuda
A
A
D019943:Amino Acid Substitution; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D002175:Candida / Q000201:enzymology; D002473:Cell Wall / Q000201:enzymology; D002687:Chitin Synthase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D015394:Molecular Structure; D011487:Protein Conformation
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; C011952:nikkomycin; D002687:Chitin Synthase