title: Synthesis of aminoglycoside-modified oligonucleotides.
abstract: [structure: see text] To study the structural requirements of aminoglycoside binding to nucleic acids, compound 1-an analogue of the naturally occurring nucleoside J-was synthesized. When incorporated into oligodeoxynucleotides, 1 leads to thermal stabilization of the resulting duplexes. The increase in pairing affinity is stronger with complementary RNA than with DNA.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Tona
authors.forename: R
authors.initials: R
authors.lastname: Bertolini
authors.forename: J
authors.initials: J
authors.lastname: Hunziker
mesh_terms: D000617:Aminoglycosides / Q000138:chemical synthesis / Q000737:chemistry*; D020029:Base Pairing; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D012313:RNA / Q000737:chemistry
chemical_list: D000617:Aminoglycosides; D009841:Oligonucleotides; D012313:RNA; D004247:DNA