[Participation of the cytochrome P450-dependent biotransformation system in realizing the toxic effects of acrylamide].
Neuro-, hepato- and geno-toxic effects of the industrial xenobiotic, acrylamide, were studied in intact rats and in rats with induced phenobarbital- and 3-methylholanthren-dependent isoforms of cytochrome P-450. The induction of the first isoform increased neuro- and hepato-toxic effects of acrylamide and decreased the extent of cell genome damage. Activation of the 3-methylholanthren-dependent cytochrome had no influence on the toxicity of this xenobiotic. Realisation of toxic effects of acrylamide may involve a decrease of the carbohydrate energy metabolism, but in the intact organism these processes precede the induction of the phenobarbital-dependent cytochrome P450.
Romanova
T A
TA
Krasnoyarsk State Agricultural University, Russia.
D020106:Acrylamide / Q000493:pharmacokinetics* / Q000633:toxicity; D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D004734:Energy Metabolism; D004790:Enzyme Induction; D008099:Liver / Q000187:drug effects; D008297:Male; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity; D009420:Nervous System / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D009153:Mutagens; D020106:Acrylamide; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital