Hypopyon after repeated transplantation of human amniotic membrane onto the corneal surface.
OBJECTIVE
The authors describe a localized probable immunoreaction after repeated transplantation of amniotic membrane (AM) onto the corneal surface.


METHODS
Interventional case report.


METHODS
Amniotic membrane was transplanted onto the corneal surface of a 78-year-old female with a deep trophic corneal ulcer resulting in temporary epithelial closure. A second and finally third amniotic membrane transplantation (AMT) was performed because of recurrent ulcerations. All three AMs were obtained from the same donor.


RESULTS
The first transplantation of the AM was without complication. However, a hypopyon developed 2 days after the second and 2 days after the third AMT, but the patient responded immediately to topical and systemic corticosteroids.


CONCLUSIONS
Immunologic, toxic, and hypersensitivity effects could have contributed to the hypopyon iritis that appeared after the second and third AMT, but not after the initial transplantation. In case of a repeated AMT, the use of AM from different donors may help to minimize the risk of an immediate postoperative intraocular inflammation.
Gabler
B
B
University Eye Clinic, Regensburg, Germany. bernhard.gabler@klinik.uni-regensburg.de
Lohmann
C P
CP
D000368:Aged; D000650:Amnion / Q000637:transplantation*; D000867:Anterior Chamber / Q000187:drug effects / Q000473:pathology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003320:Corneal Ulcer / Q000601:surgery*; D005128:Eye Diseases / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy; D012086:Reoperation; D013492:Suppuration / Q000188:drug therapy / Q000209:etiology
D000900:Anti-Bacterial Agents; D005938:Glucocorticoids