title: Assessment of iron absorption from ferric trimaltol.
abstract: Therapeutic iron compounds have limited absorption and often have side-effects, which limits patient compliance. Iron trimaltol is a novel, stable complex, formed between ferric iron (Fe3+) and maltol (3-hydroxy-2-methyl-4-pyrone), and is effective in the treatment of iron deficiency anaemia with few side-effects. However, the kinetics of iron absorption from ferric trimaltol and the reliability of normal colorimetric analysis in detecting iron absorbed from this complex have not been established. We measured increases in serum iron levels in 12 volunteers following oral challenge with four different pharmaceutical formulations of ferric trimaltol in a double-blind, cross-over, randomized study. The conventional colorimetric method for detecting serum iron was compared with thermal analyses after trichloroacetic acid (TCA) treatment of serum. Measurements of serum iron levels by TCA treatment and thermal analysis closely agreed with measurements by colorimetry. For all formulations, serum iron levels peaked at 90 min with a plateau of at least 5 h [mean (standard deviation) peak absorption 8.3% (6.3%) of ingested dose, n=48]. Absorption of iron, based on peak serum values or area under the serum curve, was not different for the four formulations (n=12 each) and correlated with the individual's iron status, as assessed by serum ferritin values (r = -0.6; P < 0.001). Normal colorimetry is suitable for analysis of serum iron levels following ingestion of ferric trimaltol. There is rapid and sustained absorption of iron from ferric trimaltol and, as with ferrous iron, uptake appears to be controlled through normal mechanisms of iron acquisition that depend upon body iron stores.
authors.affiliation: Gastrointestinal Laboratory, The Rayne Institute, London, UK. dreffitt@rayne.umds.ac.uk
authors.forename: D M
authors.initials: DM
authors.lastname: Reffitt
authors.forename: T J
authors.initials: TJ
authors.lastname: Burden
authors.forename: P T
authors.initials: PT
authors.lastname: Seed
authors.forename: J
authors.initials: J
authors.lastname: Wood
authors.forename: R P
authors.initials: RP
authors.lastname: Thompson
authors.forename: J J
authors.initials: JJ
authors.lastname: Powell
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D002424:Caustics / Q000494:pharmacology; D003124:Colorimetry; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005290:Ferric Compounds / Q000097:blood / Q000493:pharmacokinetics*; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood* / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011753:Pyrones / Q000097:blood / Q000493:pharmacokinetics*; D013053:Spectrophotometry; D013696:Temperature; D013997:Time Factors; D014238:Trichloroacetic Acid / Q000494:pharmacology
chemical_list: D002424:Caustics; D005290:Ferric Compounds; D011753:Pyrones; C115835:ferric trimaltol; D014238:Trichloroacetic Acid; D005293:Ferritins; D007501:Iron