title: Flow injection spectroscopic analysis of model drugs using on-line UV-diode array, FT-infrared and 1H-nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry.
abstract: A prototype flow injection analysis (FIA) system for the characterisation of compounds via a combination of diode array UV, 1H NMR, FT-IR spectroscopy and time-of-flight (TOF) mass spectrometry has been investigated using a number of pharmaceuticals and related compounds as model compounds. This combination of spectrometers allowed the on-flow collection of UV, 1H NMR, IR and mass spectra together with atomic composition data, enabling almost complete structural characterisation to be performed. Practical detection limits with the current system were in the region of 50 micrograms, however, the use of state of the art spectrometers would result in a significant reduction in the amount of material required.
authors.affiliation: AstraZeneca Pharmaceuticals, Mereside, Macclesfield, Cheshire, UK.
authors.forename: D
authors.initials: D
authors.lastname: Louden
authors.forename: A
authors.initials: A
authors.lastname: Handley
authors.forename: S
authors.initials: S
authors.lastname: Taylor
authors.forename: E
authors.initials: E
authors.lastname: Lenz
authors.forename: S
authors.initials: S
authors.lastname: Miller
authors.forename: I D
authors.initials: ID
authors.lastname: Wilson
authors.forename: A
authors.initials: A
authors.lastname: Sage
mesh_terms: D017022:Flow Injection Analysis / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D004364:Pharmaceutical Preparations / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations