title: Hyperbaric oxygenation induced tolerance against focal cerebral ischemia in mice is strain dependent.
abstract: SV129 or C57BL/6 mice were exposed to hyperbaric oxygenation (HBO, 5 days, 1 h every day, 100% O(2) at 3 atm absolute). One day after the 5th HBO session focal cerebral ischemia was induced. In SV129 mice, HBO induced tolerance against permanent focal cerebral ischemia (n=42, mean infarct volume reduction 27%, P=0.001), but not against transient (30 or 60 min) focal cerebral ischemia. In the C57BL/6 strain of mice, HBO did not induce tolerance against focal cerebral ischemia, even when the duration of ischemia or the HBO protocol were modified. For the first time we demonstrate that HBO can induce tolerance to focal cerebral ischemia, but this effect is strain dependent.
authors.affiliation: Department of Neurology, Humboldt University, Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Prass
authors.forename: F
authors.initials: F
authors.lastname: Wiegand
authors.forename: P
authors.initials: P
authors.lastname: Schumann
authors.forename: M
authors.initials: M
authors.lastname: Ahrens
authors.forename: K
authors.initials: K
authors.lastname: Kapinya
authors.forename: C
authors.initials: C
authors.lastname: Harms
authors.forename: W
authors.initials: W
authors.lastname: Liao
authors.forename: G
authors.initials: G
authors.lastname: Trendelenburg
authors.forename: K
authors.initials: K
authors.lastname: Gertz
authors.forename: M A
authors.initials: MA
authors.lastname: Moskowitz
authors.forename: F
authors.initials: F
authors.lastname: Knapp
authors.forename: I V
authors.initials: IV
authors.lastname: Victorov
authors.forename: D
authors.initials: D
authors.lastname: Megow
authors.forename: U
authors.initials: U
authors.lastname: Dirnagl
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology* / Q000517:prevention & control*; D002544:Cerebral Infarction / Q000473:pathology / Q000517:prevention & control; D006931:Hyperbaric Oxygenation; D019194:Ischemic Preconditioning / Q000379:methods*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013045:Species Specificity