title: [Liver transplantation with a graft taken from a heart transplant patient who was brain-dead].
abstract: The shortage of organ donors has led to progressive softening of selection criteria for organ donation. We report on hepatic transplantation in a 55-year-old woman with primary biliary cirrhosis, whose donor was a 50-year-old heart transplant recipient who became brain stem dead, due to cerebral bleeding 8 months after transplantation. An orthotopic liver transplantation was performed. The postoperative course was uneventful and the recipient was alive and had normal liver function after a 42-month follow-up. Analysis of the literature included ethical consideration, potential hepatotoxic effects of immunosuppressive drugs and modification of the graft immunogenicity. It confirms that transplanted patients should not be a priori excluded from organ donation.
authors.affiliation: Service de chirurgie générale et digestive, Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Arvieux
authors.forename: C
authors.initials: C
authors.lastname: Létoublon
authors.forename: F
authors.initials: F
authors.lastname: Bouchard
authors.forename: D
authors.initials: D
authors.lastname: Pasquier
authors.forename: T
authors.initials: T
authors.lastname: Delecour
authors.forename: D
authors.initials: D
authors.lastname: Barnoud
authors.forename: S
authors.initials: S
authors.lastname: Penillon
authors.forename: R
authors.initials: R
authors.lastname: Barnoud
authors.forename: J M
authors.initials: JM
authors.lastname: Sturm
authors.forename: H
authors.initials: H
authors.lastname: Hodaj
authors.forename: E
authors.initials: E
authors.lastname: Borel
authors.forename: G
authors.initials: G
authors.lastname: Naud
authors.forename: J
authors.initials: J
authors.lastname: Pirenne
authors.forename: J P
authors.initials: JP
authors.lastname: Zarski
mesh_terms: D001926:Brain Death; D002543:Cerebral Hemorrhage / Q000150:complications; D004992:Ethics, Medical; D005260:Female; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008105:Liver Cirrhosis, Biliary / Q000601:surgery; D016031:Liver Transplantation; D008875:Middle Aged; D014019:Tissue Donors
chemical_list: D007166:Immunosuppressive Agents