Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease.
Thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation, were assayed in postmortem brain. Basal TBARS levels were increased and oxidative stimulation produced more TBARS in AD relative to control brains. In addition, apolipoprotein E isoforms showed differing antioxidant activities, with E2 > E3 > E4, suggesting that the lowest antioxidant activity of E4 could contribute to its association with AD.
Tamaoka
A
A
Department of Neurology, University of Tsukuba, Ibaraki, Japan.
Miyatake
F
F
Matsuno
S
S
Ishii
K
K
Nagase
S
S
Sahara
N
N
Ono
S
S
Mori
H
H
Wakabayashi
K
K
Tsuji
S
S
Takahashi
H
H
Shoji
S
S
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism*; D001057:Apolipoproteins E / Q000737:chemistry / Q000378:metabolism*; D001923:Brain Chemistry; D005260:Female; D005296:Ferrous Compounds / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D015227:Lipid Peroxidation; D008297:Male; D010084:Oxidation-Reduction; D012016:Reference Values; D013702:Temporal Lobe / Q000378:metabolism* / Q000473:pathology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
D000975:Antioxidants; D001057:Apolipoproteins E; D005296:Ferrous Compounds; D017392:Thiobarbituric Acid Reactive Substances; C020748:ferrous sulfate; D006861:Hydrogen Peroxide