Compression for venous leg ulcers.
OBJECTIVE
To assess the effectiveness and cost-effectiveness of compression bandaging and stockings in the treatment of venous leg ulcers.


METHODS
Searches of 19 databases, hand searching of journals, conference proceedings and bibliographies. Manufacturers of compression bandages and stockings and an Advisory Panel were contacted for unpublished studies.


METHODS
Trials that evaluated compression bandaging or stockings, as a treatment for venous leg ulcers. There was no restriction on date or language. Ulcer healing was the primary endpoint.


METHODS
Details of eligible studies were extracted and summarised using a data extraction sheet. Data extraction was verified by two reviewers independently.


RESULTS
Twenty two trials reporting 24 comparisons were identified. Compression was more effective than no compression (4/6 trials). When multi-layered systems were compared, elastic compression was more effective than non-elastic compression (5 trials). There was no difference in healing rates between 4-layer bandaging and other high compression multi-layered systems (3 trials). There was no difference in healing rates between elastomeric multi-layered systems (4 trials). Multi-layered high compression was more effective than single layer compression (4 trials). Compression stockings were evaluated in two trials. One found a high compression stocking plus a thrombo stocking to be more effective than a short stretch bandage. The second small trial reported no difference between the compression stockings and Unna's boot. There was insufficient data to draw conclusion about the relative cost-effectiveness of different regimens.


CONCLUSIONS
Compression increases ulcer healing rates compared with no compression. Multi-layered systems are more effective than single-layered systems. High compression is more effective than low compression but there are no clear differences in the effectiveness of different types of high compression.
Cullum
N
N
Centre for Evidence Based Nursing, Department of Health Studies, University of York, Genesis 6, York, UK, YO10 5DQ. nac2@york.ac.uk
Nelson
E A
EA
Fletcher
A W
AW
Sheldon
T A
TA
D001458:Bandages; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D014647:Varicose Ulcer / Q000628:therapy*