Polymorphism of repeated regions of pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica.
Pertactin is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica that induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed that B. parapertussis pertactin is invariant, whereas B. pertussis pertactin varies mostly in region I and B. bronchiseptica pertactin varies in both repeated regions I and II, but mostly in region II. These differences may result from specific characteristics of these Bordetella species.
Boursaux-Eude
C
C
Laboratoire des Bordetella, Institut Pasteur, 75724 Paris, France.
Guiso
N
N
D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001884:Bordetella / Q000235:genetics*; D016950:Bordetella bronchiseptica / Q000235:genetics; D001886:Bordetella pertussis / Q000235:genetics; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D020449:Repetitive Sequences, Amino Acid; D017386:Sequence Homology, Amino Acid; D010566:Virulence Factors, Bordetella
D001425:Bacterial Outer Membrane Proteins; D010566:Virulence Factors, Bordetella; C068929:pertactin