[Radiation-induced thyroid cancers].
Human epithelial thyroid radiation-induced tumorigenesis is the most frequent radiation-induced tumorigenic process in man. Results of different studies, concerning the molecular mecanism(s) of epithelial thyroid radiation-associated tumorigenesis show : 1) that there is not a significant difference in the frequency of activation of ras, gsp and trk proto-oncogenes between radiation-associated and <<spontaneous >> thyroid tumors; 2) the relevant role played by RET/PTC ret proto-oncogene activating rearrangements, in the development of radiation-associated thyroid tumors originated after therapeutic radiation (mainly PTC 1) or the atomic accident of Chernobyl (mainly PTC 3) and 3) suggest that the patients who develop thyroid tumors after a history of irradiation, show a genomic instability consisting in a DNA repair defect.
Bounacer
A
A
IFR 1221 CNRS, UPR 42 du CNRS 94801 Villejuif, France.
Schlumberger
M
M
Caillou
B
B
Sarasin
A
A
Suárez
H G
HG
D029721:Drosophila Proteins; D019204:GTP-Binding Proteins / Q000235:genetics; D016147:Genes, Tumor Suppressor; D011905:Genes, ras; D006801:Humans; D009381:Neoplasms, Radiation-Induced; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D020800:Receptor, Nerve Growth Factor / Q000235:genetics; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000235:genetics
D029721:Drosophila Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D020800:Receptor, Nerve Growth Factor; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila; D019204:GTP-Binding Proteins