Lecithin-cholesterol acyltransferase: role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis.
In the past several years significant advances have been made in our understanding of lecithin-cholesterol acyltransferase (LCAT) function. LCAT beneficially alters the plasma concentrations of apolipoprotein B-containing lipoproteins, as well as HDL. In addition, its proposed role in facilitating reverse cholesterol transport and modulating atherosclerosis has been demonstrated in vivo. Analysis of LCAT transgenic animals has established the importance of evaluating HDL function, as well as HDL plasma levels, to predict atherogenic risk.
Santamarina-Fojo
S
S
Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, Maryland, USA. silvia@mdb.nhlbi.nih.gov
Lambert
G
G
Hoeg
J M
JM
Brewer
H B
HB
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood*; D001692:Biological Transport; D002784:Cholesterol / Q000097:blood*; D018014:Gene Transfer Techniques; D005923:Glomerulosclerosis, Focal Segmental / Q000201:enzymology; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood / Q000235:genetics / Q000378:metabolism*
D008074:Lipoproteins; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase