Natural killer 1.1(+) T cells and "natural suppressor" T cells in the bone marrow.
Unusual cells in the bone marrow of mice and/or humans suppress immune responses and inhibit the mixed leukocyte reaction, graft-versus-host disease, and systemic autoimmunity. Previous studies showed that these "natural suppressor" T cells expressed the CD4(-)CD8(-) T-cell receptor-alphabeta(+) phenotype. More recent studies demonstrate that the latter cells express the natural killer 1.1 (NK1.1) marker and are members of the NK1.1(+) T-cell family that secrete high levels of IFN-gamma and IL-4 after initial activation. The suppressive activity of the bone marrow NK1.1(+) T cells is dependent on their rapid secretion of high levels of IL-4. This unique cytokine secretion is not observed in conventional NK1. 1(-) T cells and can downregulate the function of the latter cells.
Strober
S
S
Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA. sstrober@stanford.edu
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000166:cytology*; D010641:Phenotype; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta