HIV infection with negative serological tests: development of seropositivity in association with highly active antiretroviral therapy.
A 19-year-old woman with well-documented HIV-1 infection had persistently negative enzyme immunoassay (EIA) and Western blot serological tests. She has plasma HIV-1 RNA levels of > 480,000 copies/mL and T-helper cell counts of approximately 100/mm3. When treated with highly active antiretroviral therapy (HAART), the viral load became undetectable (< 400 copies/mL), the T-helper cell count increased to > 500/mm3 and EIA and Western blot tests became positive.
Chockalingam
M
M
Department of Medicine, State University of New York Health Science Center at Brooklyn, USA.
Clarke
L
L
McCormack
W M
WM
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy*; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D012367:RNA, Viral / Q000032:analysis*; D016896:Treatment Outcome
D019380:Anti-HIV Agents; D012367:RNA, Viral