title: [Effect of the dopamine antagonist metoclopramide on uterine contraction].
abstract: BACKGROUND
  Because of its activity on the gastro-intestinal tract metoclopramide is used also in pregnancy, though nothing is known about its effect on the pregnant uterus. Therefore it was of interest to look after a change in uterine activity after the application of metoclopramide in a clinical relevant dose.
  
  
  METHODS
  24 strips from pregnant uteri were removed during a cesarean section, brought into an organ chamber and changes of spontaneous activity after the application of metoclopramide were measured.
  
  
  RESULTS
  A highly significant decrease of uterine activity was observed.
  
  
  CONCLUSIONS
  It was demonstrated that metoclopramide, in contrast to stomach and ureter, exerts not a tonifying but a relaxant effect on the uterus.
authors.affiliation: Universitätsklinik für Frauenheilkunde, Innsbruck.
authors.forename: W
authors.initials: W
authors.lastname: Lechner
authors.forename: A
authors.initials: A
authors.lastname: Bergant
mesh_terms: D046508:Culture Techniques; D018492:Dopamine Antagonists / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008787:Metoclopramide / Q000494:pharmacology*; D011247:Pregnancy; D014590:Uterine Contraction / Q000187:drug effects*
chemical_list: D018492:Dopamine Antagonists; D008787:Metoclopramide