[Processes of protein biosynthesis in cardiac muscle and cardioprotective effect of mu-opiate receptor ligands in immobilization stress].
Immobilization stress leads to the increase of 99mTc-pyrophosphate accumulation in the heart that points to the cardiomyocyte damage. The stress-reaction was accompanied by a decrease of protein synthesis rate in the heart muscle and immunoreactive insulin level in blood plasma and increase of blood plasma cortisol and aldosteron. Pretreatment with agonists mu-opioid receptors DALDA and DAGO (0.1 mg/kg intraperitonealy (i.p.) twice during stress) completely prevented the stress-induction decrease of myocardial protein synthesis rate, heart damage and hormonal imbalance. Cycloheximide administration (0.3 mg/kg i.p.) increased rats myocardial membrane injury during immobilization and reduced cardioprotective effect of DALDA.
Naryzhnaia
N V
NV
Laboratory of Experimental Cardiology, Tomsk Institute of Cardiology. nuclear@cardiolog.tomsk.su
Maslov
L N
LN
Lishmanov
Iu B
IuB
D000818:Animals; D002316:Cardiotonic Agents / Q000378:metabolism / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000378:metabolism / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D007103:Immobilization; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis*; D009206:Myocardium / Q000378:metabolism*; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000819:agonists* / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*
D002316:Cardiotonic Agents; D009124:Muscle Proteins; D009842:Oligopeptides; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; C063076:tyrosyl-arginyl-phenylalanyl-lysinamide; D003513:Cycloheximide