Synthesis and biological properties of new glycosidic cationic lipids for DNA delivery.
Lipidic glycosides with amino alkyl pendent groups were synthesized and evaluated for in vitro DNA transfection activity. The first representative of this new class of cationic lipids showed good gene delivery and low toxicity to HeLa and 3T3 cells.
Bessodes
M
M
Laboratoire de Vectorologie Moleculaire et Cellulaire, UMR7001 ENSCP/CNRS/Aventis Pharma Gencell, Vitry/Seine, France. michel.bessodes@aventis.com
Dubertret
C
C
Jaslin
G
G
Scherman
D
D
D016475:3T3 Cells; D000818:Animals; D000838:Anions; D004247:DNA / Q000008:administration & dosage*; D006027:Glycosides / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice
D000838:Anions; D006027:Glycosides; D008055:Lipids; D004247:DNA