Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production.
To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recruitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility.
Fruscella
P
P
Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.
Romano
M
M
Albani
D
D
Bernasconi
S
S
Luini
W
W
Bruno
A
A
Salmona
M
M
Diomede
L
L
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins; D002465:Cell Movement / Q000276:immunology; D018932:Chemokine CCL2 / Q000096:biosynthesis*; D002784:Cholesterol / Q000276:immunology; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000276:immunology; D006903:Hydroxymethylglutaryl CoA Reductases / Q000502:physiology*; D006937:Hypercholesterolemia / Q000201:enzymology* / Q000276:immunology; D007962:Leukocytes / Q000276:immunology* / Q000502:physiology; D008297:Male; D051379:Mice; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000276:immunology; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors
D022762:CCAAT-Enhancer-Binding Proteins; D018932:Chemokine CCL2; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C497388:Srebf1 protein, mouse; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases