title: Radiation treatment for incompletely resected soft-tissue sarcomas in dogs.
abstract: OBJECTIVE
  To evaluate efficacy of radiation for treatment of incompletely resected soft-tissue sarcomas in dogs.
  
  
  METHODS
  Prospective serial study.
  
  
  METHODS
  48 dogs with soft-tissue sarcomas.
  
  
  METHODS
  Tumors were resected to < 3 cm3 prior to radiation. Tumors were treated on alternate days (three 3-Gy fractions/wk) until 21 fractions had been administered. Cobalt 60 radiation was used for all treatments.
  
  
  RESULTS
  Five-year survival rate was 76%, and survival rate was not different among tumor types or locations. Four (8%) dogs developed metastases. Eight (17%) dogs had tumor recurrence after radiation. Development of metastases and local recurrence were significantly associated with reduced survival rate. Median survival time in dogs that developed metastases was 250 days. Median disease-free interval for all dogs was 1,082 days. Median time to recurrence was 700 days. Dogs that developed recurrence after a prolonged period responded well to a second surgery. Acute radiation toxicosis was minimal; osteosarcoma developed at the radiation site in 1 dog.
  
  
  CONCLUSIONS
  An excellent long-term survival rate may be achieved by treating soft-tissue sarcomas in dogs with resection followed by radiation. Amputation is not necessary for long-term control of soft-tissue sarcomas in limbs. Development of metastases and recurrence of local tumors after radiation treatment are associated with decreased survival rate. Acute and delayed radiation toxicosis was minimal with the protocol used in this study.
authors.affiliation: Animal Medical Center, New York, NY 10021, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: McKnight
authors.forename: G N
authors.initials: GN
authors.lastname: Mauldin
authors.forename: M C
authors.initials: MC
authors.lastname: McEntee
authors.forename: K A
authors.initials: KA
authors.lastname: Meleo
authors.forename: A K
authors.initials: AK
authors.lastname: Patnaik
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D015996:Survival Rate