Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families.
The role of genetic factors in the etiology of the autistic spectrum of disorders has clearly been demonstrated. Ten chromosomal regions, on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q have potentially been linked to autism.1-8 We have analyzed these chromosomal regions in a total of 17 multiplex families with autism originating from the isolated Finnish population by pairwise linkage analysis and sib-pair analysis. Mild evidence for putative contribution was found only with the 1p chromosomal region in the susceptibility to autism. Our data suggest that additional gene loci exist for autism which will be detectable in and even restricted to the isolated Finnish population.
Auranen
M
M
Department of Human Molecular Genetics, National Public Health Institute, Mannerheimintie 166, FIN-00300, Helsinki, Finland. mari.auranen@ktl.fi
Nieminen
T
T
Majuri
S
S
Vanhala
R
R
Peltonen
L
L
Järvelä
I
I
D000293:Adolescent; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002882:Chromosomes, Human, Pair 13; D002885:Chromosomes, Human, Pair 16; D002886:Chromosomes, Human, Pair 17; D002894:Chromosomes, Human, Pair 4; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D005387:Finland; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D009679:Nuclear Family
D005819:Genetic Markers