Pleural fluid and serum eosinophilia: association with fluoxetine hydrochloride.
We report the case of a patient who was treated with fluoxetine hydrochloride (Prozac) for depression. Approximately 8 weeks into the treatment, an eosinophilic pleural effusion and serum eosinophilia developed. An extensive workup for the etiology of eosinophilic pleural effusion was unrevealing. Pleural biopsy showed a nonspecific inflammatory reaction and mild fibrosis. The pleural effusion and eosinophilia resolved within a few weeks of cessation of the drug. Fluoxetine can be associated with pleural and serum eosinophilia, possibly through an allergic-mediated reaction.
Behnia
M
M
Department of Medicine, Indiana University Medical Center, Indianapolis 46202, USA.
Dowdeswell
I
I
Vakili
S
S
D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D001769:Blood; D004802:Eosinophilia / Q000139:chemically induced*; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000139:chemically induced* / Q000473:pathology
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine