title: Solid-phase synthesis of indolizidine and quinolizidine derivatives.
abstract: An efficient method for the construction of simple indolizidine and quinolizidine derivatives on solid support has been developed. An intramolecular tandem Michael reaction initiated by the nucleophilic attack of a suitably placed amino group on the tethered Wittig condensation products between 4- or 5-aminoaldehydes attached to a trityl chloride resin and 4-[(4-methylphenyl)sulfonyl]-1-(triphenylphosphoranylidene)-2-b utanon e is the key step.
authors.affiliation: Dipartimento di Chimica, Università di Ferrara, via L. Borsari 46, 44100 Ferrara, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Barco
authors.forename: S
authors.initials: S
authors.lastname: Benetti
authors.forename: C
authors.initials: C
authors.lastname: De Risi
authors.forename: P
authors.initials: P
authors.lastname: Marchetti
authors.forename: G P
authors.initials: GP
authors.lastname: Pollini
authors.forename: V
authors.initials: V
authors.lastname: Zanirato
mesh_terms: D015195:Drug Design; D007202:Indicators and Reagents; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D007202:Indicators and Reagents; D007212:Indolizines; D011807:Quinolizines