Immunomodulating activity of a polysaccharide isolated from Mori Cortex Radicis.
The immunomodulating activity of a polysaccharide isolated from Morus alba (PMA) root bark was examined in murine splenic lymphocytes. PMA enhanced proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. However, PMA suppressed primary IgM antibody production from B cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a T-cell dependent antigen sheep red blood cells. Our observations showed that the immunomodulating activity of PMA increased lymphocyte proliferation and that PMA decreased antibody production from B cells, which was distinct from those of other plant-originated polysaccharides.
Kim
H M
HM
Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon.
Han
S B
SB
Lee
K H
KH
Lee
C W
CW
Kim
C Y
CY
Lee
E J
EJ
Huh
H
H
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014197:Trees / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D011134:Polysaccharides