title: Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.
abstract: A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity.
authors.affiliation: Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd, Tochigi-ken, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Obi
authors.forename: J
authors.initials: J
authors.lastname: Uda
authors.forename: K
authors.initials: K
authors.lastname: Iwase
authors.forename: O
authors.initials: O
authors.lastname: Sugimoto
authors.forename: H
authors.initials: H
authors.lastname: Ebisu
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
mesh_terms: D019943:Amino Acid Substitution; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D002175:Candida / Q000201:enzymology; D002473:Cell Wall / Q000201:enzymology; D002687:Chitin Synthase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D015394:Molecular Structure; D011487:Protein Conformation
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; C011952:nikkomycin; D002687:Chitin Synthase