title: Chemically assisted dissection of tissues: an interesting support in abdominal myomectomy.
abstract: BACKGROUND
  The aim of this study was to verify the efficacy of sodium-2-mercaptoethanesulfonate (mesna) in the chemical separation of tissues in abdominal myomectomies when used with the traditional mechanical separation techniques.
  
  
  METHODS
  In a prospective, randomized study, 58 women underwent abdominal myomectomy. In 29 of these, we used mesna for highlighting and separating tissues, and in the other 29 we used saline solution for the same purposes. The variables evaluated included the number of myomas removed, the volume of the biggest myoma, and the total volume of the myomas removed in every intervention. We also recorded operating time, the length of hospital stay, the degree of procedure difficulty, perioperative blood loss, operative complications, and cost.
  
  
  RESULTS
  The operation was significantly shorter in the mesna group (p < 0.05) even though the volume and the number of myomas were larger. The degree of difficulty evaluated by the surgeon at the end of every operation was not significantly different in the two groups. The reduction in hemoglobin 24 hours after operation was significantly less in the patients treated with mesna (p = 0.006), but this difference was probably altered by the increase in hematocrit levels.
  
  
  CONCLUSIONS
  Because of its ability as a chemical dissector, mesna may be a useful aid in this type of benign gynecologic operation. Larger studies to confirm this are needed.
authors.affiliation: Department of Obstetrics and Gynecology, University of Parma, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Benassi
authors.forename: G
authors.initials: G
authors.lastname: Lopopolo
authors.forename: F
authors.initials: F
authors.lastname: Pazzoni
authors.forename: L
authors.initials: L
authors.lastname: Ricci
authors.forename: C
authors.initials: C
authors.lastname: Kaihura
authors.forename: F
authors.initials: F
authors.lastname: Piazza
authors.forename: E
authors.initials: E
authors.lastname: Vadora
authors.forename: C
authors.initials: C
authors.lastname: Zini
mesh_terms: D000328:Adult; D016063:Blood Loss, Surgical; D005260:Female; D013509:Gynecologic Surgical Procedures; D006400:Hematocrit; D006801:Humans; D007889:Leiomyoma / Q000601:surgery*; D007902:Length of Stay; D015080:Mesna / Q000627:therapeutic use*; D011446:Prospective Studies; D020011:Protective Agents / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000601:surgery*
chemical_list: D020011:Protective Agents; D015080:Mesna