title: Hepatitis C virus co-infection is a negative prognostic factor for clinical evolution in human immunodeficiency virus-positive patients.
abstract: A longitudinal study of human immunodeficiency virus (HIV)-infected individuals followed-up in 13 centres was performed to assess the influence of hepatitis C virus (HCV) on the clinical and immunological evolution of HIV-infected patients. Eight-hundred and twelve HIV-infected patients with known HIV acquisition date, 89 co-infected with HCV, were included in the cohort. Clinical progression was defined as: 30% decrease of Karnofsky's index; and/or 20% body weight loss; and/or acquired immune deficiency syndrome (AIDS)-defining illness; and/or death (except by accident, suicide, or overdose). Immunological progression was defined as a decrease of initial CD4 count to below 200 mm(-3). If immunological progression was not statistically different between groups (P=0.25), clinical progression was significantly faster in HCV-HIV co-infected patients in univariate (P=0.02) and multivariable survival analysis (hazard ratio=1.63, P=0.03). This argues for active management of hepatitis C chronic infection among HCV-HIV co-infected patients.
authors.affiliation: The University Hospital of Dijon, France.
authors.forename: L
authors.initials: L
authors.lastname: Piroth
authors.forename: M
authors.initials: M
authors.lastname: Grappin
authors.forename: L
authors.initials: L
authors.lastname: Cuzin
authors.forename: Y
authors.initials: Y
authors.lastname: Mouton
authors.forename: O
authors.initials: O
authors.lastname: Bouchard
authors.forename: F
authors.initials: F
authors.lastname: Raffi
authors.forename: D
authors.initials: D
authors.lastname: Rey
authors.forename: D
authors.initials: D
authors.lastname: Peyramond
authors.forename: F
authors.initials: F
authors.lastname: Gourdon
authors.forename: C
authors.initials: C
authors.lastname: Drobacheff
authors.forename: M L
authors.initials: ML
authors.lastname: Lombart
authors.forename: F
authors.initials: F
authors.lastname: Lucht
authors.forename: J M
authors.initials: JM
authors.lastname: Besnier
authors.forename: L
authors.initials: L
authors.lastname: Bernard
authors.forename: P
authors.initials: P
authors.lastname: Chavanet
authors.forename: H
authors.initials: H
authors.lastname: Portier
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D005602:France; D015658:HIV Infections / Q000150:complications* / Q000209:etiology / Q000276:immunology; D015497:HIV-1; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011379:Prognosis; D013997:Time Factors