title: In vitro activity of telithromycin (HMR 3647) and seven other antimicrobial agents against anaerobic bacteria.
abstract: We assessed the in vitro activity of telithromycin (HMR 3647) and seven other antimicrobials against 292 strains of obligately anaerobic bacteria. MICs were determined with the microdilution technique and Wilkins-Chalgren broth according to DIN 58940-83. MIC50/MIC90s (mg/L) for telithromycin were 4/4 for Bacteroides fragilis, Bacteroides ovatus and Bacteroides thetaiotaomicron, 2/4 for Fusobacterium spp. and Bilophila wadsworthia, 2/2 for Bacteroides caccae, 1/4 for Bacteroides vulgatus, 0.25/4 for Prevotella spp., > or =0.03/0.5 for Clostridium spp. and 0.125/4 for Peptostreptococcus spp.
authors.affiliation: Institute for Medical Microbiology and Epidemiology of Infectious Diseases, Liebigstrasse 24, University of Leipzig, Germany. ackermg@medizin.uni-leipzig.de
authors.forename: G
authors.initials: G
authors.lastname: Ackermann
authors.forename: R
authors.initials: R
authors.lastname: Schaumann
authors.forename: B
authors.initials: B
authors.lastname: Pless
authors.forename: M C
authors.initials: MC
authors.lastname: Claros
authors.forename: A C
authors.initials: AC
authors.lastname: Rodloff
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C106791:telithromycin