Pharmacokinetic/pharmacodynamic evaluation of a novel potassium channel opener, SKP-450, in healthy volunteers.
To evaluate the pharmacokinetic/pharmacodynamic characteristics of SKP-450, a novel K+ channel opener, a single blind, randomized, placebo-controlled, dose-rising, parallel-group study was conducted in 28 healthy volunteers. The volunteers were randomly allocated to dosage groups of 50 micrograms, 100 micrograms, 200 micrograms, and 300 micrograms. Single doses of SKP-450 were administered orally, after overnight fasting, and serial blood sampling and pharmacodynamic measurements were performed up to 48 hours after the drug was administered. The 200 micrograms group was further studied for food interactions in a crossover fashion. Drug concentrations in plasma were determined by HPLC. Hemodynamic changes after drug administration were evaluated by serial measurements of blood pressure (BP), pulse rate (PR), cardiac index (CI), and total peripheral resistance (TPR), using computerized impedance cardiography. Changes in plasma renin activity (PRA) and aldosterone concentrations (PAC) were determined 4 and 24 hours after drug administration. Both SKP-450 and SKP-818, an active metabolite, showed linear pharmacokinetic characteristics, and food intake did not significantly affect the pharmacokinetic characteristics of either compound. Dose-related pharmacological effects were obvious for both the 200 micrograms and 300 micrograms groups. Hemodynamic parameters related to vasodilation and reflex tachycardia, such as maximum changes in diastolic BP, PR, CI, and TPR, showed significant dose-dependent changes. The area under the time-effect curve (AUEC) of the parameters also showed a similar dose-dependent pattern. The PRA and PAC exhibited significant changes 4 hours after drug administration in the 300 micrograms group. Adverse effects, such as headaches, were more frequently observed at the higher dose levels. SKP-450 was generally well tolerated by these normotensive subjects. The antihypertensive efficacy of SKP-450 needs to be evaluated in hypertensive patients after multiple dosing.
Jang
I J
IJ
Department of Pharmacology, College of Medicine, Seoul National University, Korea.
Yu
K S
KS
Shon
J H
JH
Bae
K S
KS
Cho
J Y
JY
Yi
S Y
SY
Shin
S G
SG
Ryu
K H
KH
Cho
Y B
YB
Kim
D K
DK
Yoo
S E
SE
D000284:Administration, Oral; D000328:Adult; D001578:Benzopyrans / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D006261:Headache / Q000209:etiology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D015221:Potassium Channels / Q000378:metabolism*; D011760:Pyrrolidinones / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D016037:Single-Blind Method; D014665:Vasodilator Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology
D001578:Benzopyrans; D015221:Potassium Channels; D011760:Pyrrolidinones; D014665:Vasodilator Agents; C096762:KR 30450