[Catecholaminergic secretions and monovalent cations in adrenal medulla].
Taken together the results of this work indicate that 1st) The countertransport systems, [Na+]i-[Ca2+]o or [Li+]i-[Ca2+]o are implicated on the catecholamine secretory response evoked by ouabaine and lithium in the cat adrenal medulla. 2nd) Both procedures (ouabain, or lithium) induce an increment of cytosolic [Ca2+]i, secundary to the accumulation of monavalents cations (Na+ or Li+) in the cytosol, which is finally responsible for the catecholamine secretory response and 3rd) In addition to [Na+]i-[Ca2+]o or [Li+]i-[Ca2+]o counter transport systems, either Na+ or Li+ could depolarize the cell and therefore activate voltage-dependent Ca2+, and possibly Na+ channels leading to further increments of [Ca2+]i.
Sánchez García
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P
Sánchez Blasco
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EF
D000313:Adrenal Medulla / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D002414:Cations, Monovalent / Q000378:metabolism; D002417:Cattle; D002478:Cells, Cultured; D004347:Drug Interactions; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism; D008094:Lithium / Q000378:metabolism / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism
D002395:Catecholamines; D002414:Cations, Monovalent; D010042:Ouabain; D008094:Lithium; D012964:Sodium