Serum protein 90K/Mac-2BP is an independent predictor of disease severity during hepatitis C virus infection.
The serum protein designated 90K/Mac-2BP has been found at elevated concentrations in the sera of patients with various types of cancer and viral infections. The importance of the 90K/Mac-2BP serum concentrations in predicting the response towards interferon-alpha treatment for hepatitis C virus (HCV) infection prompted us to utilize a new ELISA for soluble human 90K/Mac-2BP to monitor the serum concentrations of this protein in our HCV-positive patients. Seventy HCV-PCR and anti-HCV antibody positive patients were analyzed for their serum levels of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, cholinesterase, HCV-viral load, viral subtypes, and 90K/Mac-2BP. On correlation of age and 90K/Mac-2BP levels, we found an apparent correlation that was proved rather to be a strong dependence of 90K/Mac-2BP concentrations on disease severity/duration, which increases with age. Multiple correlation analysis demonstrated the independent nature of 90K/Mac-2BP concentrations, underscoring the potential high utility of this new marker. Our data corroborate the potential of the scavenger receptor family protein 90K/Mac-2BP as an independent predictor of disease severity during HCV infection.
Kittl
E M
EM
Ludwig-Boltzmann Institute for Moleculargenetic Laboratory Diagnostics, Donauspital, SMZ-Ost, Wien, Austria.
Hofmann
J
J
Hartmann
G
G
Sebesta
C
C
Beer
F
F
Bauer
K
K
Huber
K R
KR
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D000951:Antigens, Neoplasm; D001219:Aspartate Aminotransferases / Q000097:blood; D014408:Biomarkers, Tumor; D002352:Carrier Proteins / Q000097:blood*; D002802:Cholinesterases / Q000097:blood; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005838:Genotype; D006023:Glycoproteins / Q000097:blood*; D006526:Hepatitis C / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000097:blood; D016326:Extracellular Matrix Proteins
D000410:Alanine Transaminase; D000951:Antigens, Neoplasm; D001219:Aspartate Aminotransferases; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D002802:Cholinesterases; D006023:Glycoproteins; D005723:gamma-Glutamyltransferase; C081856:LGALS3BP protein, human; D016326:Extracellular Matrix Proteins