title: Prioritization of NTP reproductive toxicants for field studies.
abstract: Population studies that evaluate human reproductive impairment are time consuming, expensive, logistically difficult, and with limited resources must be prioritized to effectively prevent the adverse health effects in humans. Interactions among health scientists, unions, and industry can serve to identify populations exposed to potential hazards and develop strategies to evaluate and apply appropriate controls. This report describes a systematic method for prioritizing chemicals that may need human reproductive health field studies. Rodent reproductive toxicants identified from the National Toxicology Program (NTP) Reproductive Assessment by Continuous Breeding (RACB) protocol were prioritized on the basis of potency of toxic effect and population at risk. This model for prioritization links NTP findings with data from the National Occupational Exposure Survey (NOES) and the Hazardous Substance Data Base (HSDB) or the High Production Volume Chemical Database (HPVC) to prioritize chemicals for their potential impact on worker populations. The chemicals with the highest priority for field study were: dibutyl phthalate, boric acid, tricresyl phosphate, and N, N-dimethylformamide.
authors.affiliation: National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Pkwy, Cincinnati OH 45226, USA. wjm2@cdc.gov
authors.forename: W J
authors.initials: WJ
authors.lastname: Moorman
authors.forename: H W
authors.initials: HW
authors.lastname: Ahlers
authors.forename: R E
authors.initials: RE
authors.lastname: Chapin
authors.forename: G P
authors.initials: GP
authors.lastname: Daston
authors.forename: P M
authors.initials: PM
authors.lastname: Foster
authors.forename: R J
authors.initials: RJ
authors.lastname: Kavlock
authors.forename: J S
authors.initials: JS
authors.lastname: Morawetz
authors.forename: T M
authors.initials: TM
authors.lastname: Schnorr
authors.forename: S M
authors.initials: SM
authors.lastname: Schrader
mesh_terms: D000818:Animals; D003245:Consensus Statements as Topic; D005260:Female; D015386:Hazardous Substances / Q000009:adverse effects*; D006292:Health Priorities; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D051379:Mice; D019055:No-Observed-Adverse-Effect Level; D016273:Occupational Exposure / Q000517:prevention & control*; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D018570:Risk Assessment; D018675:Toxicity Tests; D014481:United States
chemical_list: D015386:Hazardous Substances