Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound.
The carbapenem potassium salts 4, 7 and 8 were prepared. Their rates of beta-lactam hydrolysis and their biological activities, particularly their beta-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality.
Pfaendler
H R
HR
Department of Chemistry, University of Munich, Germany. hrp@orf.chemie.uni-muenchen.de
Weishaupt
R
R
Meffert
H
H
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D015780:Carbapenems / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D015780:Carbapenems