title: Excess triiodothyronine as a risk factor of coronary events.
abstract: BACKGROUND
  Abnormalities in cardiac function, eg, arrhythmias and congestive heart failure, often accompany thyrotoxicosis. A relationship between thyroid hormone excess and the cardiac complications of angina pectoris and myocardial infarction (MI) remains largely speculative.
  
  
  METHODS
  The results of thyroid function studies on blood samples drawn from a total of 1049 patients (aged 40 years or older) immediately on emergency medical admission were related to frequencies of angina pectoris and myocardial infarction as determined according to current diagnostic algorithms. After 3 years, those patients who had initially presented with angina pectoris or acute MI were observed for subsequent coronary events; of these (n=185), 98% of the subjects (n=181) could be reevaluated.
  
  
  RESULTS
  On hospital admission, the relative rate of angina pectoris and MI was markedly high (odds ratio, 2.6; 95% confidence interval, 1.3-5.2; P=.007) in patients with elevated serum free and total triiodothyronine (T(3)) levels. An initially elevated free T(3) level was a risk factor for subsequent coronary events during the 3-year follow-up (adjusted odds ratio, 4.8; 95% confidence interval, 1.3-17.4; P=.02).
  
  
  CONCLUSIONS
  An elevation of serum free T(3) levels at hospital admission is associated with a 2.6-fold greater likelihood of the presence of a coronary event. Moreover, an initially elevated T(3) level is associated with a 3-fold higher risk of developing a subsequent coronary event during the next 3 years. Excess T(3) seemed to be a factor associated with the development and progression of acute myocardial ischemia.
authors.affiliation: Medical Clinic 1, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Peters
authors.forename: M
authors.initials: M
authors.lastname: Ehlers
authors.forename: B
authors.initials: B
authors.lastname: Blank
authors.forename: D
authors.initials: D
authors.lastname: Exler
authors.forename: C
authors.initials: C
authors.lastname: Falk
authors.forename: T
authors.initials: T
authors.lastname: Kohlmann
authors.forename: B
authors.initials: B
authors.lastname: Fruehwald-Schultes
authors.forename: P
authors.initials: P
authors.lastname: Wellhoener
authors.forename: W
authors.initials: W
authors.lastname: Kerner
authors.forename: H L
authors.initials: HL
authors.lastname: Fehm
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D016017:Odds Ratio; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood*
chemical_list: D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine