title: HLA-A*6817, identified in the Kolla Amerindians of North-West Argentina possesses a novel nucleotide substitution.
abstract: Analysis of HLA polymorphism of the indigenous populations of Central and South America has identified many alleles not seen previously in other populations. We have described a novel allele, B*5113, previously in a Kolla Amerindian individual from North-West Argentina. Here we present a second novel allele from this population: A*6817, which differs from its closest neighbour A*68012 by a single substitution at nucleotide 419. This substitution of adenosine 419 A*68012 for thymidine in A*6817 results in a novel amino acid change (aspartate to valine) at residue 116.
authors.affiliation: Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Ramon
authors.forename: I
authors.initials: I
authors.lastname: Scott
authors.forename: S T
authors.initials: ST
authors.lastname: Cox
authors.forename: S
authors.initials: S
authors.lastname: Pesoa
authors.forename: C
authors.initials: C
authors.lastname: Vullo
authors.forename: A M
authors.initials: AM
authors.lastname: Little
authors.forename: J A
authors.initials: JA
authors.lastname: Madrigal
mesh_terms: D001118:Argentina; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide
chemical_list: D015234:HLA-A Antigens