title: Histidin as a mercurial poisoning inhibitor.
abstract: Histidin has been shown to effectively inhibit coagulation of horse oxyhemoglobin (HbO(2)) modified by mercury(II) ion bound to reactive thiol groups of protein. Kinetic parameters were measured and the histidin-to-mercury binding constant was kinetically estimated. Histidin, as other pharmaceutically acceptable compounds with some mercury-binding capacity, has been suggested to alleviate mercury intoxication conditions.
authors.affiliation: Institute of Biochemical Physics of the Russian Academy of Sciences, Kosygin St. 4, Moscow V-334, 117977, Russia. myshkin@photonics.ru
authors.forename: A E
authors.initials: AE
authors.lastname: Myshkin
authors.forename: V S
authors.initials: VS
authors.lastname: Khromova
mesh_terms: D000818:Animals; D006639:Histidine / Q000737:chemistry* / Q000494:pharmacology; D006736:Horses; D007700:Kinetics; D008630:Mercury Poisoning / Q000517:prevention & control*; D008706:Methemoglobin / Q000737:chemistry
chemical_list: D006639:Histidine; D008706:Methemoglobin