title: Is the prophylactic administration of magnesium sulphate in women with pre-eclampsia indicated prior to labour?
abstract: OBJECTIVE
  To determine whether prophylactic magnesium sulphate is necessary to prevent eclampsia and associated complications among women with pre-eclampsia prior to labour.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Tertiary referral centre.
  
  
  METHODS
  Three hundred and eighteen women with pre-eclampsia (blood pressure > or = 140/90 mmHg and > or = 2+ proteinuria) who were not in labour or for planned induction thereof and had not received magnesium sulphate during transfer.
  
  
  METHODS
  Clinical evaluation of the pregnant women with careful blood pressure control. Magnesium sulphate was withheld even in the presence of imminent eclampsia. During labour, the option of magnesium sulphate prophylaxis was left to the clinician, but magnesium sulphate was administered in cases of eclampsia.
  
  
  METHODS
  Eclampsia and related complications.
  
  
  RESULTS
  Five women (1.5%) developed eclampsia, although none developed related complications. Women presented at an early gestational age (mean 30 weeks), with high blood pressure, often suffering from headaches. Twenty pregnancies were terminated prior to viability, of which half were terminated for maternal reasons. Ten intrauterine deaths occurred. Most often fetal distress (38.6%) initiated the delivery process, which was mainly by caesarean section (68.5%). With the exception of epigastric discomfort, symptoms and signs of imminent eclampsia decreased after admission. Blood pressure values were significantly lower at delivery although biochemistry results deteriorated from admission to delivery.
  
  
  CONCLUSIONS
  In women with pre-eclampsia prior to labour, where blood pressure control was carefully applied but magnesium sulphate not given, the eclampsia rate was low and eclampsia did not appear to worsen the existing prognosis for mother or fetus.
authors.affiliation: Department of Obstetrics and Gynaecology, Tygerberg Hospital and University of Stellenbosch, South Africa.
authors.forename: D R
authors.initials: DR
authors.lastname: Hall
authors.forename: H J
authors.initials: HJ
authors.lastname: Odendaal
authors.forename: M
authors.initials: M
authors.lastname: Smith
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001794:Blood Pressure / Q000502:physiology; D004461:Eclampsia / Q000517:prevention & control*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007745:Labor Onset; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000150:complications / Q000517:prevention & control; D011247:Pregnancy
chemical_list: D000927:Anticonvulsants; D008278:Magnesium Sulfate