Notch signal transduction: a real rip and more.
The Notch signaling pathway functions in a wide variety of processes that regulate tissue patterning and morphogenesis in developing vertebrates and invertebrates. Research on the mechanism of ligand-induced Notch signal transduction has revealed a novel and essential element in the signal cascade. Some recent findings support a model in which sequential proteolytic cleavage serves to regulate Notch signal transduction.
Weinmaster
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Department of Biological Chemistry, UCLA School of Medicine, Los Angeles, 90095-1737, USA. gweinmaster@mednet.ucla.edu
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism*; D053764:Presenilin-1; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*
D008024:Ligands; D008565:Membrane Proteins; D053764:Presenilin-1; D051880:Receptors, Notch; D010450:Endopeptidases