Dictyostelium: a model for regulated cell movement during morphogenesis.
Dictyostelium has played an important role in unraveling the pathways that control cell movement and chemotaxis. Recent studies have started to elucidate the pathways that control cell sorting, morphogenesis, and the establishment of spatial patterning in this system. In doing so, they provide new insights into how cell movements within a multicellular organism are regulated and the importance of pathways that are similar to those that regulate chemotaxis of cells on two-dimensional surfaces during aggregation.
Firtel
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Center for Molecular Genetics, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093-0634, USA. rafirtel@ucsd.edu
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D000818:Animals; D002630:Chemotactic Factors / Q000378:metabolism; D002633:Chemotaxis / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism; D004023:Dictyostelium / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009024:Morphogenesis
D002630:Chemotactic Factors; D000242:Cyclic AMP