title: Persistent anaphylactic reaction after induction with thiopentone and cisatracurium.
abstract: A 6-year-old boy presented for surgery for phimosis. The anaesthetic technique included intravenous induction with thiopentone and neuromuscular blockade with cisatracurium. Severe persistent bronchospasm and central cyanosis followed the administration of these drugs. A continuous i.v. infusion of epinephrine at 0.2 microg. kg(-1) x min(-1) was necessary to break the severe refractory bronchial hyperresponsiveness. There was no previous exposure to anaesthetic drugs and no definite family history of allergy. Through increased serum eosinophil cationic protein, tryptase and histamine levels and IgE levels specific to cisatracurium, we demonstrated an IgE-mediated anaphylactic reaction to cisatracurium in the child's first exposure to this new neuromuscular blocking agent. Anaphylactic reactions to new anaesthetic drugs may be challenging to recognize and treat during general anaesthesia in children. The pathogenesis, diagnosis and management of life threatening persistent allergic reactions to intravenous anaesthetics are discussed.
authors.affiliation: Paediatric Intensive Care Unit, 'Aghia Sophia' Children's Hospital, Levadias and Thivon Street, 11527 Athens, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Briassoulis
authors.forename: T
authors.initials: T
authors.lastname: Hatzis
authors.forename: P
authors.initials: P
authors.lastname: Mammi
authors.forename: A
authors.initials: A
authors.lastname: Alikatora
mesh_terms: D000322:Adrenergic Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D000707:Anaphylaxis / Q000139:chemically induced* / Q000188:drug therapy; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D001279:Atracurium / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D001798:Blood Proteins / Q000032:analysis; D016535:Bronchial Hyperreactivity / Q000188:drug therapy; D001986:Bronchial Spasm / Q000139:chemically induced / Q000188:drug therapy; D002648:Child; D053818:Chymases; D003490:Cyanosis / Q000139:chemically induced; D047091:Eosinophil Granule Proteins; D004837:Epinephrine / Q000008:administration & dosage / Q000627:therapeutic use; D006632:Histamine / Q000097:blood; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D008407:Mast Cells / Q000201:enzymology; D019148:Neuromuscular Blockade; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000009:adverse effects*; D010688:Phimosis / Q000601:surgery; D012260:Ribonucleases; D012697:Serine Endopeptidases / Q000097:blood; D013874:Thiopental / Q000008:administration & dosage / Q000009:adverse effects*; D053802:Tryptases
chemical_list: D000322:Adrenergic Agonists; D018686:Anesthetics, Intravenous; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D007073:Immunoglobulin E; D006632:Histamine; D012260:Ribonucleases; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases; D013874:Thiopental; C101584:cisatracurium; D004837:Epinephrine