title: Sleep related O2 desaturation in COPD patients with normoxaemia and mild hypoxyaemia.
abstract: It is unknown whether daytime features predict oxygenation during sleep in COPD patients with normoxaemia or mild hypoxaemia. In this study our purpose was to evaluate by a pulse oxymeter, nocturnal desaturation in 33 COPD with PaO2 > 60 mmHg and to examine some daytime parameters as possible predictors of nocturnal hypoxaemia. A significant nocturnal desaturation has been defined by spending > or = 30% of total sleep-time with a TSTSaO2 < 90% > 30. According to this criterion we classified our patients in Desaturators (D) and Non Desaturators (ND). Our results showed that 39% of our patients were D and 61% ND. Among anthropometric and respiratory functional data we found that daytime SaO2B (r = 0.74 p < 0.001) daytime PaO2 (r = 0.47 p < 0.01) and daytime PaCO2 (r = 0.45 p < 0.05) were significantly correlated with the nocturnal oxygen desaturation and can predict the presence of sleep related hypoxaemia. In conclusion, our study confirms that a relatively high percentage of COPD patients with normoxaemia or borderline hypoxaemia exhibits significant nocturnal hypoxaemia. Further studies will suggest whether sleep related hypoxaemia deserves nocturnal oxygen therapy.
authors.affiliation: Department of Clinical Methodology and Medical Surgery Technology, University of Bari. oresta@pneumol.uniba.it
authors.forename: O
authors.initials: O
authors.lastname: Resta
authors.forename: M P
authors.initials: MP
authors.lastname: Foschino-Barbaro
authors.forename: S
authors.initials: S
authors.lastname: Talamo
authors.forename: M C
authors.initials: MC
authors.lastname: Nocerino
authors.forename: A
authors.initials: A
authors.lastname: Stefano
authors.forename: G
authors.initials: G
authors.lastname: Corvaglia
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D008176:Lung Volume Measurements; D008297:Male; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D012890:Sleep
chemical_list: D010100:Oxygen