[An assessment of the efficacy of stress-protector pharmacological preparations and hyperbaric oxygenation in patients in the perioperative period].
Modulating effects of some drugs and HBO on adaptation reaction have been studied in 74 surgical patients. Investigation methods included cardiac rhythm record (statistical analysis with histogram plotting--sympathetic activity index), tcpO2, tcpCO2, SaO2, finger pulse amplitude (vasomotor tone evaluation), and evaluation of changes in arterial pressure and heart rate. The treatment included intravenous propranolol (0.92-1.38 micrograms/kg/min) or cordanum (1.85-2.7 micrograms/kg/min) or clonidine (0.018-0.037 microgram/kg/min) or dalargin (0.55-0.83 microgram/kg/min) HBO-100% O2 for 1 h at 1.5 ATA during increase of sympathetic activity. The results indicate that all drugs and HBO modulate the adaptation response of the organism and improve the outcomes of surgery.
Kiriachkov
Iu Iu
IuIu
Khmelevskiĭ
Ia M
IaM
Sloventantor
V Iu
VIu
Vorontsova
E V
EV
D000222:Adaptation, Physiological / Q000187:drug effects; D000465:Algorithms; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000187:drug effects*; D019990:Perioperative Care / Q000379:methods* / Q000706:statistics & numerical data; D013312:Stress, Physiological / Q000517:prevention & control*; D013997:Time Factors