Genetics of hereditary colon cancer - a basis for prevention?
Hereditary colorectal cancer syndromes are among the best in vivo models to study colorectal carcinogenesis and the influence of putative modifiers of the cancer risk. The present knowledge regarding the wide range of colorectal cancer (CRC) susceptibilities and the histological and molecular changes they elicit is leading to a very dynamic and integrated concept of tumorigenesis in the colon and to new views about prevention and early treatment of cancer.
Müller
H H
HH
Research Group Human Genetics of the Devision of Medical Genetics, DKBW University of Basel, UKBB, CH 4005, Basel, Switzerland. hansjakob.mueller@unibas.ch
Heinimann
K
K
Dobbie
Z
Z
D011125:Adenomatous Polyposis Coli / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics* / Q000517:prevention & control; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics; D006801:Humans; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D012307:Risk Factors