Synthesis of polypyrrolinones on solid support.
[reaction: see text] An efficient, three-step iterative synthesis of polypyrrolinones has been achieved on solid support, setting the stage for the construction of a wide variety of libraries based on the pyrrolinone scaffold. Central to the approach is an effective end-game sequence featuring pyrrolinone ring construction with traceless release from the solid support.
Smith
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AB
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu
Liu
H
H
Okumura
H
H
Favor
D A
DA
Hirschmann
R
R
D000447:Aldehydes; D006868:Hydrolysis; D007202:Indicators and Reagents; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D011760:Pyrrolidinones / Q000138:chemical synthesis*
D000447:Aldehydes; D007202:Indicators and Reagents; D010455:Peptides; D011760:Pyrrolidinones