Synthesis of some thiazolyl-pyrazoline derivatives and preliminary investigation of their hypotensive activity.
Some 1-(4-arylthiazol-2-yl)-3,5-diaryl-2-pyrazoline derivatives were synthesized by reacting 1-thiocarbamoyl-3,5-diaryl-2-pyrazoline derivatives with phenacetylbromide in ethanol. The structural elucidation of the compounds were performed by IR, 1H-NMR and Mass spectral data and elemental analyses. The hypotensive activities of 13 compounds were evaluated by using the tail-cuff method. All examined compounds showed appreciable hypotensive activities. Clonidine was used as reference substance in the pharmacological evaluation.
Turan-Zitouni
G
G
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskisehir, Turkey. gzitouni@anadolu.edu.tr
Chevallet
P
P
Kiliç
F S
FS
Erol
K
K
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003000:Clonidine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology*
D000959:Antihypertensive Agents; D011720:Pyrazoles; D013844:Thiazoles; D003000:Clonidine