Synthesis and herbicidal activity of N-oxide derivatives.
As part of an ongoing program on the chemistry and biological activity of N-oxide-containing molecules, a number of novel 1,2, 5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline N,N'-dioxide derivatives were synthesized and evaluated for their herbicidal activity. Many of these compounds exhibited moderate to good herbicidal pre-emergence activity against Triticum aestivum. Dose-response studies were done on the more representative compounds (12, 20, and 26). The most active compound, butylcarbamoylbenzo[1,2-c]1,2,5-oxadiazole N-oxide, 26, displayed herbicidal activity at concentrations as low as 24 g/ha.
Cerecetto
H
H
Cátedra de Cereales y Cultivos Industriales, Facultad de Agronomía, Universidad de la República, Paysandú, Uruguay. hcerecet@bilbio.edu.uy
Dias
E
E
Di Maio
R
R
González
M
M
Pacce
S
S
Saenz
P
P
Seoane
G
G
Suescun
L
L
Mombrú
A
A
Fernández
G
G
Lema
M
M
Villalba
J
J
D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000138:chemical synthesis* / Q000494:pharmacology; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D010087:Oxides / Q000138:chemical synthesis* / Q000494:pharmacology
D006540:Herbicides; D010087:Oxides