Electronic excitation as a mechanism of the ion selectivity filter.
A correlation between the character of pharmacological activity and the energies of electronic transitions in some biologically active molecules, affecting the nervous system, has been found. In order to explain the correlation, a new principle of the membrane ion selectivity filter has been suggested. The principle is based on the recombination process of a metal cation, passing through the filter, with an electron, when the energy quantum (equal to the metal ionization energy) is emitted. The amino acid residue group, performing the function of the channel filter, absorbs this quantum, transits itself into an electronically excited state, changes its conformation and lets, as a result, the cation pass. The process is possible only in that case when the amino acid residue group has a transition of the same energy, therefore not all of metals can pass through the filter. From the viewpoint of this conception, an active molecule acts because of its transition into an electronically excited state of the same energy and interfering, thereby, with the natural processes.
Khvostenko
O G
OG
Institute of Molecular and Crystal Physics, Ufa Research Center, Russian Academy of Sciences. khv@mail.ru
Shishlov
N M
NM
Fokin
A I
AI
Shvedov
V I
VI
Fedotova
O A
OA
D000818:Animals; D002462:Cell Membrane; D002463:Cell Membrane Permeability; D004579:Electron Transport; D006801:Humans; D007473:Ion Channels; D017136:Ion Transport
D007473:Ion Channels