An experimental study of the adhesive potential of different meshes.
OBJECTIVE
To assess the adhesive potential and incidence of incisional hernia with three meshes.


METHODS
Open experimental study.


METHODS
Surgical Research Laboratory, Turkey.


METHODS
75 Wistar albino rats


METHODS
Abdominal walls were excised, and defects closed primarily or with polyglactin 910, polypropylene, or dura mater. Adhesions were graded and hydroxyproline concentrations measured on days 14 and 180. On day 180, the incidence of incisional hernia, and the grades of inflammation and fibrosis were also recorded.


RESULTS
The polyglactin 910 group had a higher adhesion grading than the control and dura mater groups on day 14, whereas the polypropylene group had higher adhesion grading than controls. Both polypropylene and polyglactin 910 groups had significantly higher concentration of hydroxyproline than the control and dura mater groups. On day 180, the polypropylene group had a higher adhesion grading than the controls. There were no differences in hydroxyproline concentrations, incidence of hernias, or grading of fibrosis levels among the groups.


CONCLUSIONS
Polyglactin 910 induced more fibrotic adhesions in the early postoperative period whereas polypropylene did in both the early and late postoperative periods.
Baykal
A
A
Department of General Surgery, University of Hacettepe, Faculty of Medicine, Ankara, Turkey. abaykal@hacettepe.edu.tr
Yorganci
K
K
Sokmensuer
C
C
Hamaloglu
E
E
Renda
N
N
Sayek
I
I
D000005:Abdomen / Q000601:surgery; D000818:Animals; D004388:Dura Mater; D006547:Hernia / Q000209:etiology; D011098:Polyglactin 910 / Q000009:adverse effects*; D011126:Polypropylenes / Q000009:adverse effects*; D011183:Postoperative Complications / Q000209:etiology*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology*; D014945:Wound Healing / Q000502:physiology
D011126:Polypropylenes; D011098:Polyglactin 910