Pyoderma gangrenosum in a patient with autoimmune haemolytic anaemia and complement deficiency.
About 50% of cases of pyoderma gangrenosum (PG) are associated with a variety of systemic diseases. We describe a patient with severe PG on both legs who suffered from an autoimmune haemolytic anaemia in association with a congenital deficiency of complement factors C2 and C4. To the best of our knowledge, this constellation has not been previously reported.
Coors
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Department of Dermatology, University of Erlangen-Nuremberg, Hartmannstr. 14, D-91052 Erlangen, Germany.
von den Driesch
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D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D003175:Complement C2 / Q000172:deficiency*; D003181:Complement C4 / Q000172:deficiency*; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000209:etiology*
D000893:Anti-Inflammatory Agents; D003175:Complement C2; D003181:Complement C4; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone; D008775:Methylprednisolone