title: The concept of abnormal hemispheric organization in addiction research.
abstract: In addition to the established areas of endogenous psychoses, the concept of abnormal hemispheric organization in the field of psychiatry is also generating ever greater interest in the area of research into addiction. On the basis of the demonstrably higher rate of developmental risk factors (pre-, peri-, postnatal), in particular the marker left-handedness (LH) has been interpreted as an indication of induced hemispheric 'malcontrol' in endogenous psychoses. In various studies, elevated rates of LH have also been shown in alcoholics. Alcoholism could be related to biological factors associated with anomalous cerebral dominance. In a joint study carried out by the Anton Proksch Institut in Vienna (Austria), and the University of Erlangen-Nuremberg (Germany) involving a total of 250 alcohol-dependent inpatients, the hypothesis of deviant laterality in the presence of an elevated frequency of developmental risk factors has been confirmed exclusively in male alcoholics. A comparison of subtypes has also revealed that Type IV in the Lesch typology, and Type II in the Cloninger classification, are more vulnerable subtypes. These results clearly show that there are differences to be found within the overall group of alcoholics, and underscore the need for subtyping and gender-specific studies.
authors.affiliation: Department of Psychiatry, Friedrich Alexander University of Erlangen-Nuremberg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Sperling
authors.forename: H
authors.initials: H
authors.lastname: Frank
authors.forename: P
authors.initials: P
authors.lastname: Martus
authors.forename: R
authors.initials: R
authors.lastname: Mader
authors.forename: A
authors.initials: A
authors.lastname: Barocka
authors.forename: H
authors.initials: H
authors.lastname: Walter
authors.forename: M
authors.initials: M
authors.lastname: Lesch
mesh_terms: D000437:Alcoholism / Q000145:classification* / Q000453:epidemiology / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D012307:Risk Factors