Can interleukin-10 be used as a true immunoregulatory cytokine?
Interleukin-10 (IL-10) is a cytokine that is currently regarded as a potential therapy for inflammatory diseases involving T helper 1-type responses because of its ability to downregulate several major functions of Th1 cells and macrophages. There are also evidence that IL-10 could be useful in controlling Th2-mediated inflammatory processes. However IL-10 has also immunostimulatory properties especially on B-cells and activated CD8+ T cells. These pleiotropic effects may explain the discrepancy observed after IL-10 treatment in different in vivo experimental models. We have recently shown that IL-10 induces the differentiation of a subset of regulatory CD4+ T cells (Tr1). In different in vivo models, these cells were shown to inhibit Th1 and Th2-type inflammatory responses through the secretion of IL-10. These Tr1 cells may thus be used in specific cellular therapy in order to deliver IL-10 precisely at the site of inflammation.
Wakkach
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A
INSERM U. 343, Hôpital de l'Archet, route de Saint-Antoine-de-Ginestière, 06200 Nice, France.
Cottrez
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F
Groux
H
H
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology; D015551:Autoimmunity; D002454:Cell Differentiation / Q000187:drug effects; D016207:Cytokines / Q000494:pharmacology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007166:Immunosuppressive Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D016207:Cytokines; D007166:Immunosuppressive Agents; D016753:Interleukin-10