title: Bifurcation in a simple model of the cardiovascular system.
abstract: A simple nonlinear beat-to-beat model of the human cardiovascular system has been studied. The model, introduced by DeBoer et al. was a simplified linearized version. We present a modified model which allows to investigate the nonlinear dynamics of the cardiovascular system. We found that an increase in the alpha-sympathetic gain, via a Hopf bifurcation, leads to sustained oscillations both in heart rate and blood pressure variables at about 0.1 Hz (Mayer waves). Similar oscillations were observed when increasing the beta-sympathetic gain or decreasing the vagal gain. Further changes of the gains, even beyond reasonable physiological values, did not reveal another bifurcation. The dynamics observed were thus either fixed point or limit cycle. Introducing respiration into the model showed entrainment between the respiration frequency and the Mayer waves.
authors.affiliation: Department of Medical Physics, School of Physics and Astronomy, Tel-Aviv University, Israel. solange@post.tau.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Eyal
authors.forename: S
authors.initials: S
authors.lastname: Akselrod
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D003198:Computer Simulation; D004562:Electrocardiography; D006321:Heart / Q000294:innervation; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D017711:Nonlinear Dynamics; D012815:Signal Processing, Computer-Assisted; D013564:Sympathetic Nervous System / Q000502:physiology