title: Atrophic dermatofibroma. Elastophagocytosis by the tumor cells.
abstract: A 55-year-old woman presented with an asymptomatic red plaque on the left upper back for 6 or 7 years. The lesion was depressed in response to finger pressure. The clinical diagnosis was anetoderma. Histopathologically, the characteristic cells of cellular dermatofibroma proliferated within the thinned dermis, which showed atrophy of about 60 or 70%. The proliferated cells were positive for factor XIIIa and negative for CD34. The involved dermis showed the loss of elastic fibers on elastica van Gieson stain. Electron microscopically, the proliferating cells phagocytized the elastic fibers. We report a typical case of atrophic dermatofibroma and show the possibility that the cause of this disease might be elastophagocytosis between the collagen fibers by the dermatofibroma cells.
authors.affiliation: Department of Dermatology, Fukui Medical University, Japan. kiyo@fmsrsa.fukui-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kiyohara
authors.forename: M
authors.initials: M
authors.lastname: Kumakiri
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Ohkawara
authors.forename: L M
authors.initials: LM
authors.lastname: Lao
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D001284:Atrophy; D004547:Elastic Tissue / Q000473:pathology*; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010587:Phagocytosis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D011503:Transglutaminases / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D011503:Transglutaminases