title: Immunomodulating activity of a polysaccharide isolated from Mori Cortex Radicis.
abstract: The immunomodulating activity of a polysaccharide isolated from Morus alba (PMA) root bark was examined in murine splenic lymphocytes. PMA enhanced proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. However, PMA suppressed primary IgM antibody production from B cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a T-cell dependent antigen sheep red blood cells. Our observations showed that the immunomodulating activity of PMA increased lymphocyte proliferation and that PMA decreased antibody production from B cells, which was distinct from those of other plant-originated polysaccharides.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Yusung, Taejon.
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: S B
authors.initials: SB
authors.lastname: Han
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.forename: C Y
authors.initials: CY
authors.lastname: Kim
authors.forename: E J
authors.initials: EJ
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Huh
mesh_terms: D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012756:Sheep; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014197:Trees / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D011134:Polysaccharides