Effect of quinupristin/dalfopristin on production of cytokines by human monocytes.
The effect of the novel streptogramin antibiotic quinupristin/dalfopristin (synercid) on cytokine production in vitro was examined in monocytes obtained from healthy human volunteers and stimulated with either lipopolysaccharide or heat-killed Staphylococcus aureus (Pansorbin). Synercid at concentrations that are achievable in humans (1, 5, and 10 microgram/mL) significantly suppressed production of interleukin (IL)-1alpha, IL-1beta, IL-6, IL-10, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor-alpha in a concentration-dependent manner. Thus, synercid possesses significant immunomodulatory activity, in addition to its antimicrobial activity.
Khan
A A
AA
Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, CA 94305. USA. khana@pamf.org
Slifer
T R
TR
Araujo
F G
FG
Remington
J S
JS
D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D014769:Virginiamycin / Q000494:pharmacology*
D016207:Cytokines; D014769:Virginiamycin; C062940:quinupristin-dalfopristin