title: [The I/D polymorphism of the ACE gene in children with Henoch-Schoenlein purpura].
abstract: The study group consisted of 24 children with Henoch-Schoenlein purpura (HSP) (13 girls and 11 boys, aged 66-233 months) who were treated in the Ist Pediatric Department between 1980 and 1998. The I/D polymorphism of ACE gene was determined by PCR amplification of genomic DNA with primers flanking the polymorphic region. Our preliminary results suggest lack of association between ACE genotype and kidney function. However, further follow-up studies based on sufficient number of participants are necessary to elucidate the role of ACE polymorphism in appearance and progression of renal symptoms in HSP.
authors.affiliation: I Kliniki Chorób Dzieci Katedry Chorób Dzieci.
authors.forename: A
authors.initials: A
authors.lastname: Brodkiewicz
authors.forename: A
authors.initials: A
authors.lastname: Ciechanowicz
authors.forename: A
authors.initials: A
authors.lastname: Urbańska
authors.forename: J
authors.initials: J
authors.lastname: Peregud-Pogorzelski
authors.forename: P
authors.initials: P
authors.lastname: Dzieński
authors.forename: D
authors.initials: D
authors.lastname: Subicka
authors.forename: J
authors.initials: J
authors.lastname: Fydryk
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D011695:IgA Vasculitis / Q000235:genetics*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012189:Retrospective Studies
chemical_list: D007703:Peptidyl-Dipeptidase A