title: The peripheral benzodiazepine receptors: a review.
abstract: Peripheral benzodiazepine receptors (PBRs) have been identified in various peripheral tissues as well as in glial cells in the brain. This review describes the tissue and subcellular distribution of the PBR in mammalian tissues and analyzes its many putative endogenous ligands. It deals with the pharmacological, structural and molecular characterization of the PBR, the proteins associated with the receptor (VDAC, ANC, PRAX-1) and their roles in cell growth and differentiation, cancer, steroid biosynthesis, and other physiological roles.
authors.affiliation: Laboratoire de Cytogénétique Moléculaire et Oncologie, CNRS UMR 147, Institut Curie, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Beurdeley-Thomas
authors.forename: L
authors.initials: L
authors.lastname: Miccoli
authors.forename: S
authors.initials: S
authors.lastname: Oudard
authors.forename: B
authors.initials: B
authors.lastname: Dutrillaux
authors.forename: M F
authors.initials: MF
authors.lastname: Poupon
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D006801:Humans; D008024:Ligands; D011963:Receptors, GABA-A / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D008024:Ligands; D011963:Receptors, GABA-A