title: Increased withdrawal volume per deposit for pre-operative autologous blood donation in adolescents.
abstract: OBJECTIVE
  This study was undertaken to assess the feasibility, tolerance, haemodynamic and haematologic effects of an aggressive phlebotomy schedule for autologous blood donation (ABD) in adolescents undergoing major orthopaedic surgery.
  
  
  METHODS
  Twenty adolescents were studied prospectively; 10 patients in group A donated 20% of the circulating blood volume on 2 occasions, whereas 10 patients in group B donated 10% on 4 occasions.
  
  
  RESULTS
  The amount of blood donated, subjective tolerance, cardiovascular changes during the procedure and pre-operative haemoglobin level did not differ between the study groups (group A 111+/-16 vs. group B 106+/-10 g/l). The increase in erythropoietin was greater and occurred sooner in group A than in group B.
  
  
  CONCLUSIONS
  In adolescents ABD is feasible with a reduced number of appointments as they demonstrate tolerance to phlebotomies with a volume which is double the standard per deposit.
authors.affiliation: Departments of Anaesthesia and Haematology, University Children's Hospital, Basel, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Erb
authors.forename: R
authors.initials: R
authors.lastname: Möller
authors.forename: P
authors.initials: P
authors.lastname: Christen
authors.forename: E
authors.initials: E
authors.lastname: Signer
authors.forename: F J
authors.initials: FJ
authors.lastname: Frei
mesh_terms: D000293:Adolescent; D001782:Blood Donors; D001794:Blood Pressure; D001800:Blood Specimen Collection / Q000379:methods; D001804:Blood Transfusion, Autologous / Q000379:methods*; D001810:Blood Volume; D002648:Child; D004921:Erythropoietin / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood; D006339:Heart Rate; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D017701:Reticulocyte Count; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D004921:Erythropoietin; D005293:Ferritins