title: Specific detection of epstein-barr virus in inflammatory pseudotumor of the spleen in a patient with a high serum level of soluble IL-2 receptor.
abstract: A case of inflammatory pseudotumor of the spleen is described in a 63-year-old woman who presented with an intrasplenic tumor and an elevated serum level of soluble interleukin 2 receptor (sIL-2R). Microscopic examination after removal of the spleen revealed that the tumor was composed of mixed cellular infiltrates, mainly lymphocytes and plasma cells, and spindle-cell proliferation. Epstein-Barr virus (EBV) was specifically detected in the tumor by in situ hybridization for EBV RNA. The serum level of sIL-2R level was normalized after splenectomy. EBV infection may play a role in the development of splenic inflammatory pseudotumor and the elevation of sIL-2R level.
authors.affiliation: Department of Surgery, Showa University Fujigaoka Hospital,Yokohama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: G
authors.initials: G
authors.lastname: Tate
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: A
authors.initials: A
authors.lastname: Matsumiya
authors.forename: M
authors.initials: M
authors.lastname: Kuzume
authors.forename: Y
authors.initials: Y
authors.lastname: Sanada
authors.forename: K
authors.initials: K
authors.lastname: Kumada
mesh_terms: D005260:Female; D006104:Granuloma, Plasma Cell / Q000097:blood / Q000175:diagnosis / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D013158:Splenic Diseases / Q000097:blood / Q000175:diagnosis / Q000821:virology*; D014057:Tomography, X-Ray Computed
chemical_list: D015375:Receptors, Interleukin-2