Genomic structures and sequences of two closely linked genes (AMT, TCTA) on dog chromosome 20q15.1-->q15.2.
Analysis of genomic sequence from canine chromosome 20q15.1-->q15.2 revealed the presence of two closely linked genes. The two genes represent the corresponding canine orthologs of human aminomethyltransferase (AMT) and the human T-cell leukemia translocation associated (TCTA) gene. Aminomethyltransferase or glycine cleavage system T-protein is an important enzyme in glycine metabolism. The reported canine AMT gene spans 5 kb and consists of nine exons. It encodes a protein of 403 amino acids with 88% identity to human aminomethyltransferase. Human TCTA is located on 3p21 near the breakpoint of a t(1;3) translocation observed in some cancer cell lines. The 4-kb canine TCTA gene consists of three exons and probably represents a pseudogene. It is located adjacent to AMT and very close to DAG1 and BSN.
Leeb
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T
Institute of Veterinary Medicine, University of Göttingen, Göttingen, Germany. tleeb@zucht.tiho-hannover.de
Breen
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Brenig
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D050960:Aminomethyltransferase; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018387:Codon, Initiator / Q000235:genetics; D004285:Dogs; D005091:Exons / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D019877:Hydroxymethyl and Formyl Transferases / Q000235:genetics*; D007438:Introns / Q000235:genetics*; D015458:Leukemia, T-Cell / Q000235:genetics*; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D011401:Promoter Regions, Genetic / Q000235:genetics; D011544:Pseudogenes / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014178:Translocation, Genetic / Q000235:genetics*
D018387:Codon, Initiator; D019877:Hydroxymethyl and Formyl Transferases; D050960:Aminomethyltransferase