Host-pathogen interactions in emerging and re-emerging infectious diseases: a genomic perspective of tuberculosis, malaria, human immunodeficiency virus infection, hepatitis B, and cholera.
On exposure to a pathogen, a host may resist infection, become subclinically infected, or progress through several stages from mild to severe infection. Chronic sequelae may or may not occur. Host factors, particularly host genes, influence many of these stages. We have used a model of the continuum of pathogenesis of infectious diseases to consider the effect of host genes on five pathogens of significant public health burden: Mycobacterium tuberculosis, Plasmodium species, human immunodeficiency virus, hepatitis B virus, and Vibrio cholerae. The relationships between these infections and polymorphisms in human leukocyte antigen, cytokines, other immune response, or pathogen receptor genes are reviewed. We discuss gene-gene interactions and their effects in complex settings, such as coinfections with several pathogens. Priorities for prevention and control of these pathogens include vaccines and antimicrobial drugs. Research on how host genes can influence vaccine responses and the efficacy of drugs or other interventions, as well as further research into the relationship of host genes to infectious disease outcomes, may lead to new strategies for prevention and control.
McNicholl
J M
JM
Division of AIDS, National Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333, USA. jkm7@cdc.gov
Downer
M V
MV
Udhayakumar
V
V
Alper
C A
CA
Swerdlow
D L
DL
D002771:Cholera / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D018450:Disease Progression; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014943:Global Health; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D006509:Hepatitis B / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D008288:Malaria / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control; D015233:Models, Statistical; D009017:Morbidity; D011110:Polymorphism, Genetic / Q000235:genetics; D011159:Population Surveillance; D015980:Public Health Practice; D014376:Tuberculosis / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control