title: Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury?
abstract: Nuclear factor-kappaB (NF-kappaB) is a transcription factor which resides in its unactivated form in the cytoplasm. Following activation subsequent to cerebral ischemia and reperfusion injury, NF-kappaB acts on genes for cytokines, adhesion molecules, nitric oxide synthase, cyclooxygenase-2, metalloproteinase-9, and perhaps apoptotic genes. These genes have a variety of positive and negative influences on the outcome of brain injury. The effect of manipulation of NF-kappaB needs to be examined critically, as it pertains to these reactive genes.
authors.affiliation: Department of Neurology, Medical College of Georgia, Augusta, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Carroll
authors.forename: D C
authors.initials: DC
authors.lastname: Hess
authors.forename: E F
authors.initials: EF
authors.lastname: Howard
authors.forename: W D
authors.initials: WD
authors.lastname: Hill
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D018836:Inflammation Mediators / Q000502:physiology; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000502:physiology; D015427:Reperfusion Injury / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D018836:Inflammation Mediators; D016328:NF-kappa B