title: A stereoselective synthesis of the C-10 to C-18 (right-half) fragment of mycalamides employing lewis acid promoted intermolecular aldol reaction.
abstract: [reaction: see text] Beginning with D-mannitol, a stereoselective synthesis of the right-half segment of the mycalamides has been accomplished by employing Lewis acid catalyzed intermolecular aldol reaction and oxypalladation as the key steps.
authors.affiliation: Department of Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai, 980-8578, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Toyota
authors.forename: M
authors.initials: M
authors.lastname: Hirota
authors.forename: H
authors.initials: H
authors.lastname: Hirano
authors.forename: M
authors.initials: M
authors.lastname: Ihara
mesh_terms: D000818:Animals; D002384:Catalysis; D007202:Indicators and Reagents; D008353:Mannitol / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007202:Indicators and Reagents; D008387:Marine Toxins; D011714:Pyrans; C059647:mycalamide B; C059646:mycalamide A; D008353:Mannitol