[The antimicrobial activity and acute toxicity of the polymer salts of gentamycin].
By neutralization of copolymers of N-(2-hydroxypropyl) methacrylamide with acrylic acid and copolymers of N-vinylpyrrolidone with crotonic and p-crotonoylaminophenoxyacetic acids in the presence of gentamycin, water-soluble polymer salts containing from 10 to 25 mass% of gentamycin were obtained. These salts regardless of gentamycin content completely retain high level of antimicrobial activity of gentamycin against Staphylococcus spp. and Escherichia coli and are characterized by less (by more than one order of magnitude) acute toxicity.
Solovskiĭ
M V
MV
Institute of Macromolecular Compounds, Russian Academy of Sciences, Saint-Petersburg.
Zaikina
N A
NA
Okulova
N V
NV
Belokhvostova
A T
AT
D000179:Acrylates; D000818:Animals; D003437:Crotonates; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology* / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010642:Phenoxyacetates; D011108:Polymers / Q000494:pharmacology / Q000633:toxicity; D011760:Pyrrolidinones; D013211:Staphylococcus aureus / Q000187:drug effects
D000179:Acrylates; D003437:Crotonates; D005839:Gentamicins; D010642:Phenoxyacetates; D011108:Polymers; D011760:Pyrrolidinones; C042670:N-vinyl-2-pyrrolidinone; C036658:acrylic acid