[Current data on lamotrigine].
OBJECTIVE
We analyze the most usual characteristics of lamotrigine and review the current antiepileptic indications. Similarly, we consider current hypotheses as to the mode of action during seizures which initially were not considered to be the main indication for use of the drug, as occurs with absence seizures.


METHODS
We review the adverse effects and emphasize the need to attain the desired dose after a slow, progressive increase in dosage, particularly when it is associated with valproic acid, since this therapeutic combination is very effective in refractory epilepsies. We also mention the favourable effect on the quality of life of the patients treated with this drug and in those in whom an obvious euthymic effect is seen, as well as the benefit observed in patients with mental retardation.
Casas-Fernández
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Sección de Neuropediatría, Hospital Universitario Virgen de la Arrixaca, Murcia, España. ccasas@forodigital.es
D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D000077213:Lamotrigine; D008875:Middle Aged; D011788:Quality of Life; D014227:Triazines / Q000009:adverse effects*
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine