Lipid analog with 2-nitrophenol trigger designed for liposome fusion at physiological pH.
A novel lipid analog with two long alkyl (C16) chains, an aspartate skeleton, a connecting alkyl (C8) chain, and 2-nitrophenol trigger group is synthesized by an efficient synthetic route, which can induce liposome fusion at physiological pH.
Shah
S N
SN
Biomolecules Department, National Institute of Bioscience and Human-Technology, Tsukuba, Ibaraki, Japan.
Tomohiro
T
T
Ogawa
Y
Y
Kodaka
M
M
Okuno
H
H
D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D008561:Membrane Fusion; D009596:Nitrophenols / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D008055:Lipids; D008081:Liposomes; D009596:Nitrophenols; C045573:2-nitrophenol