Alterations in neurochemistry during retinal degeneration.
Retinitis pigmentosa refers to a family of hereditary retinal degenerations that lead to photoreceptor death and vision loss. The underlying cause(s) are not known. In recent years there has been accumulating evidence of neurochemical changes during degeneration. In particular, the amino acids glutamate, GABA, and glycine show alterations in labelling intensity in subsets of neurons. Furthermore, there are differences in the labelling of the precursors, glutamine and aspartate, prior to, during, and following loss of photoreceptors, suggesting that the metabolic pathways involved in neurotransmitter formation and degradation may be abnormal. In addition, there is an elevation in glutamine and arginine content within Müller cells prior to the onset of photoreceptor death. Investigations evaluating Müller cell function indicate that formation and degradation of glutamate, in particular, is abnormal in the degenerating retina from an early age. These studies suggest that even though the primary genetic defect of the RCS rat is within the retinal pigment epithelium, Müller cells develop abnormally, and may contribute to the observed photoreceptor loss.
Fletcher
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Department of Anatomy and Cell Biology, The University of Melbourne, Parkville, Victoria, Australia. e.fletcher@unimelb.edu.au
D000818:Animals; D000831:Animals, Newborn; D001224:Aspartic Acid / Q000032:analysis; D018698:Glutamic Acid / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology; D005973:Glutamine / Q000032:analysis; D005998:Glycine / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D018377:Neurotransmitter Agents / Q000032:analysis* / Q000378:metabolism; D020419:Photoreceptor Cells, Vertebrate / Q000473:pathology; D051381:Rats; D012160:Retina / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D012162:Retinal Degeneration / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000378:metabolism; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D018377:Neurotransmitter Agents; D005973:Glutamine; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D005998:Glycine