title: [Cellular neurothekeoma, a rare cutaneous tumor. Anatomo-clinical and immunohistochemical study of 2 cases].
abstract: Cellular neurothekeoma is an unusual cutaneous tumor described in 1986. We report two new cases in 14-year-old girls. Both tumors measured less than one centimeter and were located on the forearm and the shoulder. They had a plexiform architecture and were developed in the dermis and the dermo-hypodermic junction. Spindle and epithelioid tumor cells were immunoreactive for vimentin, NKI-C3, NSE, CD68 and smooth muscle actin. There was no recurrence 2 and 7 months after the operation. Cellular neurothekeoma is a benign tumor. Its histogenesis is still unknown. Histological and immunohistochemical features, with positivity of the tumor cells for NKI-C3, a non specific melanocytic marker, and negativity for S-100 protein and HMB-45, allow to differentiate cellular neurothekeoma from myxoid neurothekeoma and melanocytic tumors.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital Nord, Amiens.
authors.forename: D
authors.initials: D
authors.lastname: Chatelain
authors.forename: J
authors.initials: J
authors.lastname: Ricard
authors.forename: M
authors.initials: M
authors.lastname: Colombat
authors.forename: C
authors.initials: C
authors.lastname: Ghighi
authors.forename: F
authors.initials: F
authors.lastname: Thelu
authors.forename: C
authors.initials: C
authors.lastname: Cordonnier
authors.forename: M F
authors.initials: MF
authors.lastname: Gontier
authors.forename: H
authors.initials: H
authors.lastname: Sevestre
mesh_terms: D000199:Actins / Q000032:analysis; D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D018321:Neurothekeoma / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D000199:Actins; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D010751:Phosphopyruvate Hydratase; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule