title: Ventricular motion during the ejection phase: a computational analysis.
abstract: In the present paper, the study of the ventricular motion during systole was addressed by means of a computational model of ventricular ejection. In particular, the implications of ventricular motion on blood acceleration and velocity measurements at the valvular plane (VP) were evaluated. An algorithm was developed to assess the force exchange between the ventricle and the surrounding tissue, i.e., the inflow and outflow vessels of the heart. The algorithm, based on the momentum equation for a transitory flowing system, was used in a fluid-structure model of the ventricle that includes the contractile behavior of the fibers and the viscous and inertial forces of the intraventricular fluid. The model calculates the ventricular center of mass motion, the VP motion, and intraventricular pressure gradients. Results indicate that the motion of the ventricle affects the noninvasive estimation of the transvalvular pressure gradient using Doppler ultrasound. The VP motion can lead to an underestimation equal to 12.4 +/- 6.6%.
authors.affiliation: Department of Bioengineering and Centro di Bioingegneria e Innovazioni Tecnologiche in Cardiochirurgia, Politecnico di Milano, and Instituti di Ricovero e Cura a Carattere Scientifico San Raffaele, 20133 Milan, Italy. reaelli@biomed.polimi.it
authors.forename: A
authors.initials: A
authors.lastname: Redaelli
authors.forename: F
authors.initials: F
authors.lastname: Maisano
authors.forename: J J
authors.initials: JJ
authors.lastname: Schreuder
authors.forename: F M
authors.initials: FM
authors.lastname: Montevecchi
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D006321:Heart / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D013318:Stroke Volume / Q000502:physiology*; D013599:Systole / Q000502:physiology*; D018608:Ultrasonography, Doppler; D016276:Ventricular Function