title: Structurally and functionally distinct mouse hsp70 family members Mot-1 and Mot-2 proteins are encoded by two alleles.
abstract: The mouse mortalin proteins Mot-1 and Mot-2 differ by two amino acids in their carboxy-terminus. These proteins are differentially localized in the cell cytoplasm and have contrasting biological activities. The genetic relationship between Mot-1 and Mot-2 was deciphered by mouse family analyses. Mot-1 and Mot-2 segregated in F1 and F2 progeny, providing direct evidence that the two proteins are encoded by two alleles.
authors.affiliation: National Institute of Bioscience and Human-Technology, AIST, Tsukuba, Ibaraki, Japan.
authors.forename: S C
authors.initials: SC
authors.lastname: Kaul
authors.forename: E
authors.initials: E
authors.lastname: Duncan
authors.forename: T
authors.initials: T
authors.lastname: Sugihara
authors.forename: R R
authors.initials: RR
authors.lastname: Reddel
authors.forename: Y
authors.initials: Y
authors.lastname: Mitsui
authors.forename: R
authors.initials: R
authors.lastname: Wadhwa
mesh_terms: D000483:Alleles; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008957:Models, Genetic; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
chemical_list: D002352:Carrier Proteins; D018840:HSP70 Heat-Shock Proteins; C083794:Hspa9 protein, mouse; C115087:Hspa9-ps1 protein, mouse