[Drug-induced enterocolitis. Important differential diagnosis in the investigation of diarrhea and intestinal hemorrhage].
This article is a review of the side-effects of drugs affecting the small and large intestines. Pseudomembranous colitis is caused by antibiotics facilitating an overgrowth of Clostridium difficile. A hemorrhagic colitis, generally self-limiting, can be caused by penicillin, amoxycillin and ampicillin. Toxicity of NSAID may induce intestinal ulcers, diaphragm-like strictures, perforation, colitis and relapse of inflammatory bowel disease. Drug-induced lymphocytic colitis has been reported due to ticlopidine, Cyclo 3 Fort, and occasionally by ranitidine, carbamazepine, vinburnine, tardyferon, and flutamide. Sulphasalazine and 5-ASA can cause relapse of ulcerative colitis. Neutropenic enterocolitis is a severe complication to cytotoxic therapy for cancer. Ischemic colitis can be caused by drugs inducing mesenteric vasoconstriction.
Tysk
C
C
Sektionen för gastroenterologi, Regionsjukhuset i Orebro. curt.tysk@orebroll.se
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects; D003113:Colonoscopy; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000139:chemically induced; D004760:Enterocolitis / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000175:diagnosis; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply / Q000187:drug effects / Q000473:pathology; D050607:Organogold Compounds; D010406:Penicillins / Q000009:adverse effects; D012460:Sulfasalazine / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D018501:Antirheumatic Agents; D050607:Organogold Compounds; D010406:Penicillins; D012460:Sulfasalazine