Copper-mediated cross-coupling of aryl boronic acids and alkyl thiols.
[reaction: see text] The cross-coupling of aryl boronic acids and alkanethiols mediated by copper(II) acetate and pyridine in anhydrous dimethylformamide affords aryl alkyl sulfides in good yield with a wide variety of substituted aryl boronic acids. The method is applicable to the synthesis of aryl sulfides of cysteine.
Herradura
P S
PS
Departments of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0446, USA.
Pendola
K A
KA
Guy
R K
RK
D000478:Alkylation; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D019888:Nelfinavir / Q000138:chemical synthesis / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D001897:Boronic Acids; D017320:HIV Protease Inhibitors; D013438:Sulfhydryl Compounds; D003300:Copper; D019888:Nelfinavir