title: Synthesis and bioactivities of novel piperidylpyrimidine derivatives: inhibitors of tumor necrosis factor-alpha production.
abstract: New piperidylpyrimidine derivatives, including quinazolines, were prepared, and their abilities to inhibit TNF-alpha production evaluated. Some compounds showed potent inhibitory activity in mouse macrophages stimulated with LPS. The synthesis and structure activity relationships of these compounds are described.
authors.affiliation: Research Center, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan. nfujiwar@sumitomopharm.co.jp
authors.forename: N
authors.initials: N
authors.lastname: Fujiwara
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Iwai
authors.forename: A
authors.initials: A
authors.lastname: Kurimoto
authors.forename: S
authors.initials: S
authors.lastname: Murata
authors.forename: H
authors.initials: H
authors.lastname: Kawakami
mesh_terms: D000818:Animals; D051379:Mice; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D010880:Piperidines; D011743:Pyrimidines; D014409:Tumor Necrosis Factor-alpha