title: In vitro potency of moxifloxacin, clinafloxacin and sitafloxacin against 248 genetically defined clinical isolates of Staphylococcus aureus.
abstract: The in vitro potency of three newer fluoroquinolones, moxifloxacin, clinafloxacin and sitafloxacin was tested against 248 genetically defined Staphylococcus aureus isolates, comprising 116 unrelated S. aureus, seven heterogeneous intermediate vancomycin-resistant S. aureus strains as well as 125 clonally related methicillin-resistant S. aureus. All strains were susceptible to clinafloxacin and sitafloxacin based on an investigational breakpoint of 1 mg/L and were less influenced by mutations within the grl and gyr gene loci. In one-quarter to one-third of the strains tested, reserpine decreased slightly the MICs of moxifloxacin, clinafloxacin and sitafloxacin. Compared with moxifloxacin, clinafloxacin and sitafloxacin showed a significantly increased anti-staphylococcal potency.
authors.affiliation: Institute for Medical Microbiology and Virology, Heinrich-Heine University Dusseldorf, Germany. schmitfj@uni-duesseldorf.de
authors.forename: F J
authors.initials: FJ
authors.lastname: Schmitz
authors.forename: A C
authors.initials: AC
authors.lastname: Fluit
authors.forename: D
authors.initials: D
authors.lastname: Milatovic
authors.forename: J
authors.initials: J
authors.lastname: Verhoef
authors.forename: H P
authors.initials: HP
authors.lastname: Heinz
authors.forename: S
authors.initials: S
authors.lastname: Brisse
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds; D016521:Electrophoresis, Gel, Pulsed-Field; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D011804:Quinolines; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; C057477:clinafloxacin; C076246:sitafloxacin; D000077266:Moxifloxacin