title: Octyl 2-cyanoacrylate in sutureless surgery of extraocular muscles: an experimental study in the rabbit model.
abstract: BACKGROUND
  Sutureless surgery for strabismus eliminates the risk of perforating the ocular bulb in patients with extremely thin sclerae. Thus far, however, the results obtained with tissue adhesives such as the cyanoacrylates instead of sutures have been less than satisfactory.
  
  
  METHODS
  A new adhesive, octyl 2-cyanoacrylate, was tested in 36 rabbit eyes in which the superior rectus was recessed 5 mm. In 36 other eyes the same operation was performed using 5/0 Vicryl sutures. Animals were killed 1, 3, 5, 15, 30 and 45 days after surgery. One eye from each animal was used for histopathological examination of the reinserted muscle and sclera, while the other was used in a tensiometric test to measure how many grams of weight were needed to detach the muscle from its new insertion site.
  
  
  RESULTS
  The tensile strength of the bond achieved with the cyanoacrylate adhesive was 94+/-12 g 1 day after surgery (vs 238+/-19 g in the suture group) and 520+/-24 g after 45 days (vs 576+/-27 g with sutures). No cases of slippage, muscle detachment, or local tissue reactions were observed in either group. There were no differences in histological findings between the eyes of the two groups.
  
  
  CONCLUSIONS
  Although further study will be necessary before this technique can be used in humans, our findings indicate that octyl 2-cyanoacrylate is superior to the cyanoacrylate adhesives used in the past in terms of adhesion and holding power; given its favorable toxicity profile, this product may offer interesting applications in the future.
authors.affiliation: Department of Ophthalmology, Catholic University of Rome, Italy. riccib@tiscalinet.it
authors.forename: B
authors.initials: B
authors.lastname: Ricci
authors.forename: F
authors.initials: F
authors.lastname: Ricci
authors.forename: P E
authors.initials: PE
authors.lastname: Bianchi
mesh_terms: D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use*; D004195:Disease Models, Animal; D009801:Oculomotor Muscles / Q000601:surgery*; D011817:Rabbits; D013285:Strabismus / Q000601:surgery*; D013536:Suture Techniques / Q000592:standards; D013718:Tensile Strength; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate