Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group.
Plasma and cerebrospinal fluid (CSF) indinavir concentrations were measured by high-performance liquid chromatography. The median concentration in plasma exceeded that in CSF 10-fold. The modeled CSF curve was flat at 155 nM, and the estimated ratio of the areas under the CSF and plasma concentration-time curves was 6%. We conclude that CSF indinavir concentrations are lower than levels in plasma but exceed the clinical 95% inhibitory concentration range.
Letendre
S L
SL
HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA. slentendre@ucsd.edu
Capparelli
E V
EV
Ellis
R J
RJ
McCutchan
J A
JA
D002851:Chromatography, High Pressure Liquid; D015658:HIV Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D017320:HIV Protease Inhibitors / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D006801:Humans; D019469:Indinavir / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D008297:Male
D017320:HIV Protease Inhibitors; D019469:Indinavir