Synthesis and bioactivities of novel piperidylpyrimidine derivatives: inhibitors of tumor necrosis factor-alpha production.
New piperidylpyrimidine derivatives, including quinazolines, were prepared, and their abilities to inhibit TNF-alpha production evaluated. Some compounds showed potent inhibitory activity in mouse macrophages stimulated with LPS. The synthesis and structure activity relationships of these compounds are described.
Fujiwara
N
N
Research Center, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan. nfujiwar@sumitomopharm.co.jp
Fujita
H
H
Iwai
K
K
Kurimoto
A
A
Murata
S
S
Kawakami
H
H
D000818:Animals; D051379:Mice; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D010880:Piperidines; D011743:Pyrimidines; D014409:Tumor Necrosis Factor-alpha