Platelet serotonin uptake is higher in early-onset than in late-onset alcoholics.
The main objective of this study was to compare platelet serotonin (5-HT) uptake between early-onset alcoholics (EOA) and late-onset alcoholics (LOA). Subjects were 24 dependent male alcoholic in-patients and 21 healthy control subjects. 5-HT uptake was quantified by incubating platelets with [3H]5-HT at various concentrations (0.5 to 1000 nM). 5-HT uptake was higher in EOA, compared to both the LOA and control groups (P < 0.02) at the highest 5-HT concentration (1000 nM). No significant difference was found between LOA and controls or between EOA + LOA and controls. Previous studies have shown that 5-HT uptake was higher in platelets, lymphocytes, and brain of alcoholics vs controls, but our data suggest that higher platelet serotonin transporter function is limited to EOA, not LOA.
Javors
M
M
Department of Psychiatry, The University of Texas Health Science Center, San Antonio 78229, USA.
Tiouririne
M
M
Prihoda
T
T
D000328:Adult; D017668:Age of Onset; D000437:Alcoholism / Q000097:blood* / Q000453:epidemiology*; D000704:Analysis of Variance; D001792:Blood Platelets; D006801:Humans; D008297:Male; D012701:Serotonin / Q000097:blood*
D012701:Serotonin