Anergic T cells as active regulators of the immune response.
T cell anergy is one of the mechanisms leading to the establishment and maintenance of peripheral tolerance. Recent data from our and other laboratories indicate that anergic T cells are not functionally inert but in fact are capable of regulating the immune response in an active manner. In this review, we describe our viewpoint on how anergic self-reactive T cells could contribute to regulation of the immune response.
Taams
L S
LS
Institute of Infectious Diseases and Immunology, Department of Immunology, Utrecht University, The Netherlands.
Wauben
M H
MH
D000818:Animals; D017635:Clonal Anergy / Q000276:immunology*; D006801:Humans; D017634:Self Tolerance / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*