[Renal transplantation in children in the Czech Republic].
The aim of the study is to review results of pediatric renal transplantation in center in Prague, Czech Republic. Results are compared with the registry data from Europe and United States. Patients, who underwent RTx at the University Hospital Motol, Prague (Czech Republic) between 1977 and the end of 1999, were analyzed. Since 1977 128 Rtx from cadaveric donors were performed in children in mean age 12.8 +/- 4.1 years. In 1977-1987, patients were treated with prednisone and azathioprine, and since 1988, cyclosporine A, added to prednisone and azathioprine. Sequential quadruple immunosuppression was used only in few highly sensitized patients. Acute graft rejections were treated with methylprednisolone pulses, antithymocyte globulin and monoclonal antibodies OKT3, in selected cases. In 1988 and 1999 cyclosporine A was replaced by tacrolimus as initial immunosuppression in some patients. The number of Tx ranged between 5 and 13 per year. Patients and graft survival were significantly lower in the first time period 1977-1987 with a median patients 5-year survival rate of only 50% and graft survival 30%. In the last period (1988-1999) 5-year patients survival is 90% and 5-year graft survival is 68% (p = 0.01). Two cases of posttransplant lymphoproliferative disease were diagnosed so far. One of them died several months after RTx, the other received cytostatic therapy for Hodgkin tumor and graft function was maintained. Main causes of graft failure were chronic rejection followed by acute steroid resistant rejections, severe cytomegalovirus infections, noncompliance, vascular thrombosis, and recurrence of original disease.
Feber
J
J
1-st Department of Paediatrics, Transplant Center Motol, University Hospital Motol, Praha, Czech Republic.
Spatenka
J
J
Janda
J
J
Kreisinger
J
J
Simkova
E
E
Duśek
J
J
Vondrak
K
K
Seeman
T
T
Moravek
J
J
Zeman
L
L
D000293:Adolescent; D000328:Adult; D002391:Catchment Area, Health; D002648:Child; D018153:Czech Republic / Q000453:epidemiology; D005060:Europe; D006084:Graft Rejection / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D012042:Registries