title: Holt-Oram syndrome revisited. Two patients in the same family.
abstract: Holt-Oram syndrome was first described in 1960 as an association of familial heart disease and musculoskeletal abnormalities. The most important findings include atrial septal defects, atrioventricular conduction abnormalities, vascular hypoplasia, and upper limb musculoskeletal deformities. We report two patients with this syndrome in the same family and discuss the variability of the musculoskeletal abnormalities and their association with the cardiac morphologic defects. Both patients in this study had associated eosinophilia, which has not been reported in the literature.
authors.affiliation: Hospital São Francisco da Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: J D
authors.initials: JD
authors.lastname: Frota Filho
authors.forename: W
authors.initials: W
authors.lastname: Pereira
authors.forename: T L
authors.initials: TL
authors.lastname: Leiria
authors.forename: M
authors.initials: M
authors.lastname: Vallenas
authors.forename: P E
authors.initials: PE
authors.lastname: Leães
authors.forename: C
authors.initials: C
authors.lastname: Blacher
authors.forename: E
authors.initials: E
authors.lastname: Lúcio
authors.forename: F A
authors.initials: FA
authors.lastname: Lucchese
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000235:genetics*; D000328:Adult; D004802:Eosinophilia / Q000175:diagnosis; D006228:Hand Deformities, Congenital / Q000175:diagnosis / Q000235:genetics*; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D013577:Syndrome; D013933:Thumb / Q000002:abnormalities*