Effects of intestinal endotoxemia on pathogenesis of liver injury induced by thioacetamide.
OBJECTIVE
To study the effect of intestinal endotoxemia on pathogenesis of liver injury induced by thioacetamide (TAA).


METHODS
Twenty-six male Wistar rats were divided into 4 groups, namely: normally control group (N), colectomy control group (C), colectomy+TAA group (C+T), TAA group (T). The changes in plasma biochemistry were measured.


RESULTS
Plasma endotoxin levels were significantly higher in TAA group than normally control group. Plasma endotoxin levels in colectomy+TAA group were close to that of normally control group. Plasma ALT activity in colectomy+TAA group increased significantly compared with that of normal control group, but markedly lower than that in TAA group. Plasma endotoxin levels were positively correlated to ALT activity in T and C+T groups (r=0. 985, P<0.01).


CONCLUSIONS
TAA itself has a deleterious effect to hepatic cells. It can also induce intestinal endotoxemia in which the liver injury is more inclined to occur and severe.
Liu
L
L
The Institute for Hepatology, Shanxi Medical University, Taiyuan 030001, China.
Han
D
D
Ren
D
D
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019446:Endotoxemia / Q000150:complications*; D007422:Intestines / Q000382:microbiology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide / Q000633:toxicity*
D013853:Thioacetamide; D000410:Alanine Transaminase