A model for ZnII-containing-beta-lactamase: synthesis, X-ray crystal structure of a zinc(II) complex bearing thiol group and hydrolysis of phosphate diester.
A novel N3S1 typed tripodal ligand bearing an SH group, N-(mercaptoethyl)-di(2-pyridylmethyl)amine, DPASH, was prepared and its zinc(II) complex, [ZnII(DPAS)Cl], was structurally characterized by X-ray crystallography. [ZnII(DPAS)Cl] promoted hydrolysis of sodium bis(p-nitrophenyl)hydrogenphosphate), BNP-.
Kurosaki
H
H
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Tawada
T
T
Kawasoe
S
S
Ohashi
Y
Y
Goto
M
M
D018360:Crystallography, X-Ray; D004952:Esters; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D008956:Models, Chemical; D011487:Protein Conformation; D013438:Sulfhydryl Compounds; D015032:Zinc / Q000737:chemistry*; D001618:beta-Lactamases / Q000138:chemical synthesis / Q000737:chemistry*
D004952:Esters; D013438:Sulfhydryl Compounds; D001618:beta-Lactamases; D015032:Zinc