Apoptosis in the vasculature: mechanisms and functional importance.
Apoptotic death has now been recognized in a number of common and threatening vascular diseases, including atherosclerosis. Interest in apoptosis research relates to the fact that apoptosis, in contrast to oncosis, is a highly regulated process of cell death which raises the hope for the development of specific therapeutic strategies to alter disease progression. This review summarizes the mechanisms involved in vascular endothelial and smooth muscle cell survival/apoptosis, and the potential roles of apoptotic death in atherosclerosis and restenosis. The potential effects of modulation of apoptosis in these diseases are also discussed.
Mallat
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INSERM U541 & IFR "Circulation-Paris VII", 41, Bd de la Chapelle, 75475 Paris, Cedex 10, France.
Tedgui
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D000818:Animals; D017209:Apoptosis; D001161:Arteriosclerosis / Q000209:etiology / Q000628:therapy; D002450:Cell Communication; D003327:Coronary Disease / Q000209:etiology; D016228:Endothelial Growth Factors / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D008077:Lipoproteins, LDL / Q000633:toxicity; D008222:Lymphokines / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D013314:Stress, Mechanical; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D018836:Inflammation Mediators; D008077:Lipoproteins, LDL; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C099252:oxidized low density lipoprotein