Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbits.
Idiopathic dilated cardiomyopathy is a severe disease of unknown etiology. Accumulating evidence suggests that agonist-like autoantibodies against the beta 1 adrenoceptor in the circulation of dilated cardiomyopathy may play an important role. The aim of this study was to evaluate the effects of the selective beta 1-adrenoceptor blocker, bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol. Cross-reactivity to beta 2 adrenoceptors was observed in some of the immunized rabbits, but disappeared almost entirely after 6 months. As compared to the beta 1-adrenoceptor peptide immunized group without bisoprolol treatment, bisoprolol treated beta 1-receptor peptide immunized group showed increase in the wall thickness and decreases in cavity dimension in anatomical measurements and only mild alterations in macro- and microscopic examinations. Thus, our study clearly demonstrated a beneficial effect of bisoprolol in rabbits who have developed autoimmune myocardial damage.
Matsui
S
S
Department of Cardiology, Sahlgrenska University Hospital, Göteborg, Sweden.
Persson
M
M
Fu
H M
HM
Hayase
M
M
Katsuda
S
S
Teraoka
K
K
Kurihara
T
T
Fu
M L
ML
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D017298:Bisoprolol / Q000494:pharmacology*; D002306:Cardiac Volume / Q000187:drug effects; D002311:Cardiomyopathy, Dilated / Q000276:immunology* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D011817:Rabbits; D018342:Receptors, Adrenergic, beta-1 / Q000276:immunology*
D000319:Adrenergic beta-Antagonists; D018342:Receptors, Adrenergic, beta-1; D017298:Bisoprolol