title: A proposed classification of mastocytosis incorporating molecular genetics.
abstract: As an understanding of the molecular genetic causes of different forms of mastocytosis is developed, the therapy of choice may depend on the specific genetic abnormalities expressed by a patient's neoplastic mast cells. The authors propose a new classification system for mastocytosis that incorporates both molecular-genetic and clinical data. This system provides a theoretic framework for mast cell researchers and helps practicing physicians in estimating prognosis and determining therapeutic options for individual patients.
authors.affiliation: Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA. j1691@columbia.edu
authors.forename: B J
authors.initials: BJ
authors.lastname: Longley
authors.forename: D D
authors.initials: DD
authors.lastname: Metcalfe
mesh_terms: D000328:Adult; D017668:Age of Onset; D019943:Amino Acid Substitution; D000818:Animals; D019070:Cell Lineage; D002648:Child; D003062:Codon / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics; D004285:Dogs; D004790:Enzyme Induction; D006801:Humans; D012515:Mast-Cell Sarcoma / Q000235:genetics / Q000662:veterinary; D008415:Mastocytosis / Q000145:classification* / Q000453:epidemiology / Q000235:genetics; D051379:Mice; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D011519:Proto-Oncogenes; D012867:Skin / Q000473:pathology; D019089:Stem Cell Factor / Q000502:physiology; D014582:Urticaria Pigmentosa / Q000145:classification / Q000235:genetics
chemical_list: D003062:Codon; D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit