title: Guest and subunit exchange in self-assembled ionophores.
abstract: [reaction: see text] Self-assembled ionophores, formed by hydrogen bonding of isoG 1 around a cation, are dynamic structures. Multinuclear NMR spectroscopy in CD(3)CN-CDCl(3) showed that cation exchange is >10(4) faster than exchange of isoG 1 ligand in (isoG 1)(10)-Cs(+) Ph(4)B(-). The cationic guest also affected the kinetic stability of the complex. 2D-EXSY NMR experiments in CDCl(3) showed that ligand exchange was 2 orders of magnitude faster for the Li(+)-decamer than for the Cs(+)-decamer.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park 20742, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cai
authors.forename: V
authors.initials: V
authors.lastname: Sidorov
authors.forename: Y F
authors.initials: YF
authors.lastname: Lam
authors.forename: R A
authors.initials: RA
authors.lastname: Flowers
authors.forename: J T
authors.initials: JT
authors.lastname: Davis
mesh_terms: D002412:Cations / Q000378:metabolism; D006151:Guanosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D006860:Hydrogen Bonding; D017136:Ion Transport; D007476:Ionophores / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure
chemical_list: D002412:Cations; D007476:Ionophores; D008024:Ligands; D006151:Guanosine