[The chemotherapeutic efficacy of ciprofloxacin and lomefloxacin in the inhalation method of infecting white mice with tularemia].
Peculiarities of the protective effect of ciprofloxacin and lomefloxacin were studied and the optimal regimens of their use were determined in multifactor experiments on albino mice infected with finally dispersed aerosol of the virulent strain of the European subspecies of Francisella tularensis. As for protective effect, the fluoroquinolones provided high percentage of the animal survival. The optimal course of the treatment was at least 7 days. The interval of 0 to 48 hours between the infection and the start of the treatment had no statistically significant effect on chemotherapeutic efficacy of fluoroquinolones.
D'iakov
S I
SI
Research Institute of Military Medicine, Ministry of Defence of the Russian Federation, St. Petersburg.
Bubnov
V P
VP
Lebedeva
I K
IK
Sidorenko
S V
SV
Moskalenko
V I
VI
D000336:Aerosols; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D024841:Fluoroquinolones; D051379:Mice; D010316:Particle Size; D015363:Quinolones / Q000627:therapeutic use*; D012107:Research Design; D014406:Tularemia / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality
D000336:Aerosols; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D002939:Ciprofloxacin; C053091:lomefloxacin