title: Chlamydia pneumoniae seropositivity is associated with carotid artery intima-media thickness.
abstract: OBJECTIVE
  Infection may both augment the atherosclerotic process and contribute to later manifestations of overt clinical disease. Chlamydia pneumoniae elementary bodies have been detected in atherosclerotic lesions. The aim of the present study was to investigate whether elevated titers of antibodies and circulating immune complexes to C pneumoniae were associated with ultrasound findings indicating presence of atherosclerosis in the carotid artery.
  
  
  METHODS
  Serum titers of antibodies to C pneumoniae (IgM, IgA, IgG, and circulating immune complex) were related to intima-media thickness (IMT) and plaque status measured by B-mode ultrasound in the carotid artery in 113 men with treated hypertension and at least 1 of the following risk factors: hypercholesterolemia, smoking, or diabetes.
  
  
  RESULTS
  Any of the titers was elevated in 56 (50%) men, and common carotid artery IMT was thicker in this group compared with the 57 men without any elevated titers (1.00 versus 0.92 mm, P<0.05). There were no accompanying differences in blood pressure, lipid levels, blood glucose, or smoking. Elevation of separate antibody types and circulation immune complex were also associated with increased IMT. In the latter group, systolic blood pressure was higher among seropositive patients compared with those who had no circulating immune complex. Seropositivity was not related to plaque status.
  
  
  CONCLUSIONS
  Seropositivity for C pneumoniae was associated with an increased intima-media thickness in the common carotid artery but not plaque status in hypertensive men at high risk for cardiovascular disease.
authors.affiliation: Department of Medicine, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Hulthe
authors.forename: J
authors.initials: J
authors.lastname: Wikstrand
authors.forename: H
authors.initials: H
authors.lastname: Gnarpe
authors.forename: J
authors.initials: J
authors.lastname: Gnarpe
authors.forename: S
authors.initials: S
authors.lastname: Agewall
authors.forename: B
authors.initials: B
authors.lastname: Fagerberg
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D000936:Antigen-Antibody Complex / Q000097:blood; D002340:Carotid Artery Diseases / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D017536:Carotid Artery, Common / Q000382:microbiology / Q000473:pathology; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology*; D016993:Chlamydophila pneumoniae; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D017539:Tunica Intima / Q000382:microbiology / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M