title: Hippocampal and striatal [(3)H]5-HT reuptake under acute stressors in two rat strains differing for their emotivity.
abstract: Spontaneously hypertensive rats and Lewis rats differ in their anxiety levels and in their serotonergic and corticotropic responses to stress. Since the 5-HT transporter plays a key role in 5-HT neurotransmission, we have analyzed whether hippocampal and/or striatal [(3)H]5-HT reuptake kinetics are altered by stress in a strain-dependent manner. It was found that forced swimming, treadmill running, or restraint for 30 min affected neither hippocampal nor striatal [(3)H]5-HT reuptake K(m) and V(max) values in the two rat strains. This study, which is the first to examine the impact of acute stress on [(3)H]5-HT reuptake with respect to the nature of the stressor, the brain region analyzed, and the rat strain, could reinforce the hypothesis that extracellular 5-HT levels during stress are representative of 5-HT release.
authors.affiliation: Laboratoire de Physiologie de l'Exercice Musculaire et du Sport, Université Bordeaux II, 33076, Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Duclos
authors.forename: P
authors.initials: P
authors.lastname: Mormède
authors.forename: G
authors.initials: G
authors.lastname: Manier
authors.forename: F
authors.initials: F
authors.lastname: Chaouloff
mesh_terms: D000818:Animals; D001007:Anxiety / Q000378:metabolism* / Q000523:psychology; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology; D005080:Exercise Test; D006624:Hippocampus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011918:Rats, Inbred SHR; D012146:Rest; D012149:Restraint, Physical; D012420:Running / Q000502:physiology; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology; D013550:Swimming / Q000502:physiology
chemical_list: D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors