Cytokines and T cells in host defense.
Soluble and cell-bound ligands profoundly influence the differentiative fate of lymphocytes during an immune response. Recent advances have been made in understanding the role of cytokine signals and costimulatory signals in the regulation of T cell responses associated with resistance or susceptibility to infection. There has also been recent progress in defining the requirements for the generation and maintenance of immunologic memory, a critical component of adaptive immunity.
Hunter
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CA
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. chunter@phl. vet.upenn.edu
Reiner
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SL
D000818:Animals; D018122:B7-1 Antigen / Q000276:immunology; D001424:Bacterial Infections; D018106:CD28 Antigens / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D010272:Parasitic Diseases / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology
D018122:B7-1 Antigen; D018106:CD28 Antigens; D016207:Cytokines