title: Taxus canadensis abundant taxane: conversion to paclitaxel and rearrangements.
abstract: An efficient conversion of Taxus canadensis abundant taxane, 9-dihydro-13-acetylbaccatin III to baccatin III is described. Since the synthesis of paclitaxel from baccatin III has been reported, this work can be used for additional supply of this powerful anticancer drug. In addition, new taxanes derived from skeletal rearrangements originating from oxidation reduction reactions of the Canadian yew major taxane, are reported.
authors.affiliation: Université du Quebec, INRS-Institut Armand-Frappier, Laval, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Nikolakakis
authors.forename: G
authors.initials: G
authors.lastname: Caron
authors.forename: A
authors.initials: A
authors.lastname: Cherestes
authors.forename: F
authors.initials: F
authors.lastname: Sauriol
authors.forename: O
authors.initials: O
authors.lastname: Mamer
authors.forename: L O
authors.initials: LO
authors.lastname: Zamir
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017239:Paclitaxel / Q000031:analogs & derivatives / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014197:Trees / Q000737:chemistry*
chemical_list: D017239:Paclitaxel