Fetal and adult human CNS stem cells have similar molecular characteristics and developmental potential.
The mammalian central nervous system (CNS) contains multipotent stem cells that develop into neurons, astrocytes and oligodendrocytes. Our current data show that fetal and adult human CNS stem cell isolates display similar proliferation kinetics, differentiate into three major cell types of the nervous system and express similar sets of regulatory genes. However, each individual CNS stem cell isolate could be distinguished by its specific gene expression and developmental potential.
Palm
K
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Neurofunctional Surgery Center, Department of Surgery, The CSMC Burns & Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Boulevard, Davis Building, Room 4018, Los Angeles, CA 90048, USA.
Salin-Nordström
T
T
Levesque
M F
MF
Neuman
T
T
D001253:Astrocytes / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D015415:Biomarkers; D001921:Brain / Q000166:cytology* / Q000196:embryology; D001923:Brain Chemistry / Q000235:genetics; D002454:Cell Differentiation / Q000502:physiology; D005333:Fetus / Q000166:cytology; D018507:Gene Expression Regulation, Developmental; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics; D064231:Nestin; D009474:Neurons / Q000737:chemistry / Q000166:cytology* / Q000502:physiology; D009836:Oligodendroglia / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D016601:RNA-Binding Proteins / Q000235:genetics; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology* / Q000502:physiology; D014404:Tubulin / Q000235:genetics
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins; C491297:MSI1 protein, human; C577484:NES protein, human; D009419:Nerve Tissue Proteins; D064231:Nestin; D016601:RNA-Binding Proteins; D014404:Tubulin