title: Clinical use of nafarelin in the treatment of leiomyomas. A review of the literature.
abstract: OBJECTIVE
  To review the efficacy and safety of nafarelin in the treatment of leiomyomas.
  
  
  METHODS
  A literature review of published clinical trials was conducted. Six studies, including a total of 602 patients with leiomyomas, were reviewed. Patients received intranasal nafarelin, 50-400 micrograms twice daily for three to six months. Vaginal bleeding patterns, leiomyoma and uterine size, surgical conditions and adverse effects were assessed.
  
  
  RESULTS
  Nafarelin consistently suppressed estrogen production, reduced leiomyoma and uterine size, and controlled menorrhagia. The significant reduction in uterine bleeding and amenorrhea resulting from administration of nafarelin was associated with a rise in mean hemoglobin concentrations. In addition, nafarelin improved hematologic parameters in women with and without anemia. Nafarelin was well tolerated, although hot flushes were the most commonly reported adverse events. Measured bone mineral density decreased significantly during treatment, although by six to nine months post-treatment, it increased to values not significantly different from baseline. The adverse effects of nafarelin were generally reversible after treatment withdrawal.
  
  
  CONCLUSIONS
  Nafarelin treatment of women with symptomatic leiomyomas effectively decreases uterine bleeding; improves hematologic parameters; manages symptoms of menometrorrhagia, dysmenorrhea and pelvic discomfort; reduces uterine and myoma size; and is well tolerated. Reduction in bone mineral density occurs, but levels return to, or near, baseline levels within six months after treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Yokohama City University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Minaguchi
authors.forename: J M
authors.initials: JM
authors.lastname: Wong
authors.forename: M C
authors.initials: MC
authors.lastname: Snabes
mesh_terms: D015746:Abdominal Pain / Q000517:prevention & control; D002986:Clinical Trials as Topic; D005260:Female; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy*; D008595:Menorrhagia / Q000517:prevention & control; D017274:Nafarelin / Q000627:therapeutic use*; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D006728:Hormones; D017274:Nafarelin