Anticholinergic medication for the unstable bladder: prospective trials of imipramine/propantheline versus penthienate and oxybutynin versus penthienate.
A comparison was made of three drug regimens: imipramine (Tofranil)/propantheline, oxybutynin (Ditropan) and penthienate bromide (Monodral). Two comparative trials were performed in prospective studies, using a randomization and cross-over design. All the drugs were found to improve the urinary symptoms and urodynamic changes associated with the unstable bladder, but penthienate was shown to be more effective than imipramine/propantheline. Its effect on the unstable bladder was equivalent to that of oxybutynin. Side-effects were common and most common with oxybutynin. However, the inability of these drugs to prevent the uninhibited detrusor contractions of the unstable bladder consistently and objectively was demonstrated.
Clarke
B
B
Department of Obstetrics and Gynecology, University of Queensland and Royal Women's Hospital, Australia.
D018759:Adrenergic Uptake Inhibitors / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D007231:Infant, Newborn; D008333:Mandelic Acids / Q000627:therapeutic use*; D010276:Parasympatholytics / Q000627:therapeutic use; D011446:Prospective Studies; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D016896:Treatment Outcome; D014555:Urination Disorders / Q000188:drug therapy*
D018759:Adrenergic Uptake Inhibitors; D018680:Cholinergic Antagonists; D008333:Mandelic Acids; D010276:Parasympatholytics; D000644:Quaternary Ammonium Compounds; C102258:penthienate; C005419:oxybutynin; D007099:Imipramine