title: Botulinum toxin treatment of cocontractions after birth-related brachial plexus lesions.
abstract: The authors studied botulinum toxin type A therapy of severe biceps-triceps cocontractions after nerve regeneration following birth-related brachial plexus lesions. Six children (age, 2 to 4 years) were treated two to three times over a period of 8 to 12 months with 40 mouse units of botulinum toxin at two sites of the triceps muscle. Elbow range of motion improved from 0 to 25 to 50 deg to 0 to 25 to 100 deg (p < 0.05), and muscle force of elbow flexion increased from a mean of Medical Research Council classification 1.7 to 3.7 (p < 0.05). After a 1-year follow-up, there was no clinical recurrence.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Germany. rollnik.jens@mh-hannover.de
authors.forename: J D
authors.initials: JD
authors.lastname: Rollnik
authors.forename: R
authors.initials: R
authors.lastname: Hierner
authors.forename: M
authors.initials: M
authors.lastname: Schubert
authors.forename: Z L
authors.initials: ZL
authors.lastname: Shen
authors.forename: S
authors.initials: S
authors.lastname: Johannes
authors.forename: M
authors.initials: M
authors.lastname: Tröger
authors.forename: K
authors.initials: K
authors.lastname: Wohlfarth
authors.forename: A C
authors.initials: AC
authors.lastname: Berger
authors.forename: R
authors.initials: R
authors.lastname: Dengler
mesh_terms: D001720:Birth Injuries / Q000188:drug therapy* / Q000503:physiopathology; D001905:Botulinum Toxins / Q000008:administration & dosage*; D020516:Brachial Plexus Neuropathies / Q000188:drug therapy* / Q000503:physiopathology; D002675:Child, Preschool; D004576:Electromyography; D005260:Female; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology
chemical_list: D001905:Botulinum Toxins