[Proteolytic specificity of plasmin with respect to adhesive proteins].
We showed that plasmin specifically hydrolyzes proteins participating in cell adhesion (fibronectin, vitronectin, and laminin) and does not affect nonadhesive proteins, such as albumin, ovalbumin, and alkaline phosphatase. These and some earlier results allow us to speak of the specific antiadhesive activity of plasmin, which significantly extends the concepts regarding the functional importance of this protein and indicates that it directly participates in the regulation of cell adhesion, the remodeling of the extracellular matrix, and, therefore, in cell migration.
Shvyrkova
I G
IG
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Moscow, Russia.
Muranova
T A
TA
D002448:Cell Adhesion; D005109:Extracellular Matrix / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D007797:Laminin / Q000378:metabolism*; D019096:Vitronectin / Q000378:metabolism*
D005353:Fibronectins; D007797:Laminin; D019096:Vitronectin; D005341:Fibrinolysin