title: Adjuvant high-dose interferon alfa-2b in patients with high-risk melanoma.
abstract: We performed an analysis of toxicity and survival in stage III melanoma patients receiving adjuvant interferon alfa-2b (IFN). This was a retrospective single-arm analysis of 40 patients with stage III melanoma who received (IFN) administered at maximum tolerated doses of 20 mU/m2/day intravenously (i.v.) for 1 month and 10 mU/m2 three times per week subcutaneously (s.c.) for 48 weeks. Toxicity in our series is comparable to that experienced in the Eastern Cooperative Oncology Group (ECOG) 1684 trial, except for higher rates of dose-limiting myelosuppression and hepatotoxicity. All 40 patients experienced constitutional symptoms, but only 14/40 (35%) experienced grade 3 to 4 symptoms. Of the 40 patients, 36 (90%) experienced neurologic symptoms, but only seven (17.5%) experienced grade 3 to 4 neurotoxicity. Two patients stopped treatment because of severe psychiatric symptoms; one patient attempted suicide, and a psychosis developed in another. Thirty-nine (97.5%) patients experienced myelosuppression; 31 (77.5%) developing grade 3 to 4 myelosuppression. Hepatotoxicity was evident in 39 (97.5%) patients, and 26 (65%) experienced grade 3 to 4 hepatotoxicity. Three patients (7.5%) experienced mild renal toxicity. At a median follow-up of 27 months from initiation of therapy, there have been 19 relapses (47.5% disease-free survival [DFS]) and 10 deaths (75% OS) resulting from progression of disease. The DFS compares with the treatment arm in ECOG 1684 at 27 months, but overall survival is higher in our series of patients at the same time point. In a single program setting, IFN can be administered with similar side effects and outcome profiles seen in multi-institutional studies. Modifications in the induction regimen resulted in notably higher hematologic and hepatic toxicities but did not preclude administering further therapy and did not result in increased attrition rate among patients: only nine patients (22.5%) had their treatment stopped as a result of IFN-related toxicity. In comparison, 26% of patients had to have their treatment discontinued because of toxicity in ECOG 1684.
authors.affiliation: Melanoma Program at Massachusetts General Hospital, and Dana Farber Cancer Institute, Boston 02114, USA.
authors.forename: E
authors.initials: E
authors.lastname: Jonasch
authors.forename: U N
authors.initials: UN
authors.lastname: Kumar
authors.forename: G P
authors.initials: GP
authors.lastname: Linette
authors.forename: F S
authors.initials: FS
authors.lastname: Hodi
authors.forename: R J
authors.initials: RJ
authors.lastname: Soiffer
authors.forename: B F
authors.initials: BF
authors.lastname: Ryan
authors.forename: A J
authors.initials: AJ
authors.lastname: Sober
authors.forename: M C
authors.initials: MC
authors.lastname: Mihm
authors.forename: H
authors.initials: H
authors.lastname: Tsao
authors.forename: R G
authors.initials: RG
authors.lastname: Langley
authors.forename: B A
authors.initials: BA
authors.lastname: Cosimi
authors.forename: M A
authors.initials: MA
authors.lastname: Gadd
authors.forename: K K
authors.initials: KK
authors.lastname: Tanabe
authors.forename: W
authors.initials: W
authors.lastname: Souba
authors.forename: H A
authors.initials: HA
authors.lastname: Haynes
authors.forename: R
authors.initials: R
authors.lastname: Barnhill
authors.forename: R
authors.initials: R
authors.lastname: Osteen
authors.forename: F G
authors.initials: FG
authors.lastname: Haluska
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D018572:Disease-Free Survival; D004305:Dose-Response Relationship, Drug; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000401:mortality; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use* / Q000633:toxicity; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000401:mortality; D008875:Middle Aged; D011994:Recombinant Proteins; D012189:Retrospective Studies; D012307:Risk Factors; D012878:Skin Neoplasms / Q000188:drug therapy / Q000401:mortality; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins