title: [Acute lymphoblastic leukemia in adults. Apropos of 42 cases].
abstract: Between 1989 and 1995, 42 cases with acute lymphoblastic leukemia (18 males and 24 females) were diagnosed in our institution. Median age was 38.5 years (range, 16-88 years). Leukocyte count was more than 30.10(9)/l in 54% of cases. According to the French-American-British (FAB) criteria, 67% were classified L1 and 33% L2. Sixteen patients were treated with 12LA80 protocol, 14 patients with LALA 85 protocol, 6 patients with LALA 87 protocol and 6 patients with EORTC protocol. Complete remission was achieved in 22 cases (52%), 8 cases (20%) failed to respond and 12 (28%) died during induction. Relapse was observed in 10 cases. The 4-year survival rate was 28% confirming the worse prognosis of this leukemia when treated with standard chemotherapy.
authors.affiliation: Service d'Hématologie Clinique, CHU Farhat Hached de Sousse, Tunisie.
authors.forename: M A
authors.initials: MA
authors.lastname: Laatiri
authors.forename: S
authors.initials: S
authors.lastname: Chehata
authors.forename: A
authors.initials: A
authors.lastname: Amouri
authors.forename: N
authors.initials: N
authors.lastname: Bouaouina
authors.forename: C
authors.initials: C
authors.lastname: Gayed
authors.forename: A
authors.initials: A
authors.lastname: Saad
authors.forename: S
authors.initials: S
authors.lastname: Ennabli
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate; D014416:Tunisia / Q000453:epidemiology