title: New Synthetic Technology for the Mild and Selective One-Carbon Homologation of Hindered Aldehydes in the Presence of Ketones.
abstract: A selective, mild, and highly efficient method has been uncovered during the total synthesis of the CP molecules to accomplish the one-carbon homologation of sterically hindered aldehydes in the presence of acid- and base-labile moieties, Michael acceptors, and even other carbonyl groups such as reactive and epimerizable ketones. Mechanistic studies have revealed a neutral reagent for the rapid collapse of cyanohydrins to ketones.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, and Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093.
authors.initials: KC
authors.lastname: Nicolaou
authors.initials: G
authors.lastname: Vassilikogiannakis
authors.initials: R
authors.lastname: Kranich
authors.initials: PS
authors.lastname: Baran
authors.initials: YL
authors.lastname: Zhong
authors.initials: S
authors.lastname: Natarajan