title: Concentration of cardiac troponin I in a horse with a ruptured aortic regurgitation jet lesion and ventricular tachycardia.
abstract: An 18-year-old Thoroughbred gelding was evaluated because of sudden onset of ventricular tachycardia and signs of colic. Three years earlier, a diastolic decrescendo murmur, consistent with aortic regurgitation, had been detected, but the horse continued to perform well and compete successfully. Cardiac ultrasonographic examination revealed a defect in the interventricular septum below the aortic root, and serum concentrations of cardiac troponin I (cTnI) were higher than those measured in clinically normal horses. Repeated development of tachyarrhythmia during hospitalization prompted a decision to euthanatize the horse. A ruptured endocardial jet lesion below the aortic valve with formation of a cleft into the interventricular septum was found on necropsy. This report of increased serum cTnI concentrations in a horse with myocardial disease and our other findings suggest that assessment of cardiac troponin concentrations may be a useful tool in the evaluation of horses with suspected myocardial disease.
authors.affiliation: Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824-1314, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Cornelisse
authors.forename: H C
authors.initials: HC
authors.lastname: Schott
authors.forename: N B
authors.initials: NB
authors.lastname: Olivier
authors.forename: T P
authors.initials: TP
authors.lastname: Mullaney
authors.forename: A
authors.initials: A
authors.lastname: Koller
authors.forename: D V
authors.initials: DV
authors.lastname: Wilson
authors.forename: F J
authors.initials: FJ
authors.lastname: Derksen
mesh_terms: D000818:Animals; D001022:Aortic Valve Insufficiency / Q000097:blood / Q000150:complications / Q000662:veterinary*; D003402:Creatine Kinase / Q000097:blood; D004452:Echocardiography / Q000662:veterinary; D004699:Endocardium / Q000473:pathology; D017809:Fatal Outcome; D006352:Heart Ventricles / Q000473:pathology; D006734:Horse Diseases / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D006736:Horses; D007527:Isoenzymes; D008297:Male; D012422:Rupture, Spontaneous / Q000097:blood / Q000175:diagnosis / Q000662:veterinary; D017180:Tachycardia, Ventricular / Q000097:blood / Q000150:complications / Q000662:veterinary*; D019210:Troponin I / Q000097:blood*
chemical_list: D007527:Isoenzymes; D019210:Troponin I; D003402:Creatine Kinase