title: Purpurinimides as photosensitizers: effect of the presence and position of the substituents in the in vivo photodynamic efficacy.
abstract: This study presents a novel approach for the regioselective synthesis of a series of alkyl ether analogues of purpurin-18-N-alkylimide. In the purpurinimide series, this is the first example which demonstrates that the presence and position of the substituents in the macrocycle makes a remarkable difference in the in vivo PDT efficacy.
authors.affiliation: Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: A
authors.initials: A
authors.lastname: Rungta
authors.forename: G
authors.initials: G
authors.lastname: Zheng
authors.forename: J R
authors.initials: JR
authors.lastname: Missert
authors.forename: W R
authors.initials: WR
authors.lastname: Potter
authors.forename: T J
authors.initials: TJ
authors.lastname: Dougherty
authors.forename: R K
authors.initials: RK
authors.lastname: Pandey
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000458:Cyanobacteria / Q000737:chemistry; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011166:Porphyrins / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011166:Porphyrins