Improved dissolution rate of poorly soluble drug by incorporation of buffers.
This study focused on comparing dissolution rates of indomethacin after co-compressing with three different buffers (calcium carbonate, sodium carbonate, and sodium citrate) at pH 2 and 7. Factors affecting the dissolution rate were also examined, such as type and particle size of buffer and weight-to-weight ratio of drug to buffer. It was found that, at pH 7, the release rates of indomethacin with sodium carbonate (< 74 microns, all proportions) and sodium citrate (< 74 microns, 75% loading) at a 20-min test time were about 10-fold and 6-fold greater, respectively, than that of indomethacin alone. When the drug and buffer were compressed into tablets using a tableting machine, the release rates of indomethacin for the control, sodium carbonate incorporated (25% and 75% buffer loading), and sodium citrate incorporated (75% buffer loading) at a 15-min test time were 50%, 90%, 66%, and 67%, respectively.
Preechagoon
D
D
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Thailand. detpre@kku.ac.th
Udomprateep
A
A
Manwiwattanagul
G
G
D002021:Buffers; D002119:Calcium Carbonate / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002951:Citrates / Q000737:chemistry*; D007213:Indomethacin / Q000737:chemistry*; D000077559:Sodium Citrate; D012995:Solubility; D013607:Tablets
D002021:Buffers; D002254:Carbonates; D002951:Citrates; D013607:Tablets; D000077559:Sodium Citrate; C005686:sodium carbonate; D002119:Calcium Carbonate; D007213:Indomethacin