title: General surgery in haemophiliac patients.
abstract: With improvements in medical technology, more and larger surgical procedures are performed in haemophiliac patients, but rarely reported in the surgical literature. A retrospective study from a 10 year period from one referral centre identified a total of 68 operations performed in haemophiliac patients. The levels of the defective factors were carefully monitored preoperatively and postoperatively, and replaced according to a standard formula. Special caution was taken to avoid any postoperative medication or procedures that could provoke haemorrhagic complications.Two patients suffered postoperative bleeding complications that were managed conservatively. Inhibitory factors were detected preoperatively in one case, and postoperatively in another, and were managed with aggressive replacement therapy. There was no mortality, and the overall morbidity rate was 6%. With adequate preoperative and postoperative monitoring of the clotting factors, meticulous haemostasis during surgery, careful postoperative nursing, and timely replacement therapy, haemophiliac patients can be operated with good results. Postoperative bleeding complications are rare, and usually amenable to conservative management.
authors.affiliation: 1st Surgical Department, University of Athens, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Bastounis
authors.forename: E
authors.initials: E
authors.lastname: Pikoulis
authors.forename: A
authors.initials: A
authors.lastname: Leppäniemi
authors.forename: D
authors.initials: D
authors.lastname: Alexiou
authors.forename: C
authors.initials: C
authors.lastname: Tsigris
authors.forename: A
authors.initials: A
authors.lastname: Tsetis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006467:Hemophilia A / Q000628:therapy*; D002836:Hemophilia B / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000628:therapy; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative / Q000379:methods*; D016896:Treatment Outcome; D014842:von Willebrand Diseases / Q000628:therapy*
chemical_list: D001779:Blood Coagulation Factors