title: Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold.
authors.affiliation: Central Research Division, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, USA. ralph_p_robinson@groton.pfizer.com
authors.forename: R P
authors.initials: RP
authors.lastname: Robinson
authors.forename: E R
authors.initials: ER
authors.lastname: Laird
authors.forename: J F
authors.initials: JF
authors.lastname: Blake
authors.forename: J
authors.initials: J
authors.lastname: Bordner
authors.forename: K M
authors.initials: KM
authors.lastname: Donahue
authors.forename: L L
authors.initials: LL
authors.lastname: Lopresti-Morrow
authors.forename: P G
authors.initials: PG
authors.lastname: Mitchell
authors.forename: M R
authors.initials: MR
authors.lastname: Reese
authors.forename: L M
authors.initials: LM
authors.lastname: Reeves
authors.forename: E J
authors.initials: EJ
authors.lastname: Stam
authors.forename: S A
authors.initials: SA
authors.lastname: Yocum
mesh_terms: D044482:Benzeneacetamides; D017364:Collagenases / Q000737:chemistry; D015195:Drug Design; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D053509:Matrix Metalloproteinase 13; D061965:Matrix Metalloproteinase Inhibitors; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: C410930:3-(4-(4-fluorophenyloxy)phenyl)-2-oxopyrrolidine-4-hydroxamic acid; D044482:Benzeneacetamides; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D011760:Pyrrolidinones; D017364:Collagenases; D053509:Matrix Metalloproteinase 13