Disease progression in sporadic inclusion body myositis: observations in 78 patients.
Functional decline for each decade at symptom onset and need for cane, walker, or wheelchair were assessed in 78 biopsy-proved patients with sporadic inclusion body myositis. Patients with disease onset between 40 and 59 years used a walker after 10.2 +/- 5.8 years, whereas those with disease onset between 60 and 79 years used a walker after 5.7 +/- 5.0 years (p = 0.05). Because patients progress faster to disability when symptoms begin after the age of 60, age at disease onset may define patient subsets for stratification in clinical trials.
Peng
A
A
Neuromuscular Diseases Section, National Institute of Neurologic Diseases and Stroke, National Institutes of Health, Bethesda, MD, USA.
Koffman
B M
BM
Malley
J D
JD
Dalakas
M C
MC
D000328:Adult; D000368:Aged; D004185:Disability Evaluation; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000175:diagnosis*; D009460:Neurologic Examination