title: Microbial transformation of 2-hydroxy and 2-acetoxy ketones with Geotrichum sp.
abstract: Biotransformation of a series of o-, m- and p-substituted alpha-hydroxy- and alpha-acetoxyphenylethanones 1a-h and 9a-g with Geotrichum sp. led to the corresponding 1,2-diols 2 and/or monoacetates 10 in moderate to excellent enantiomeric excesses. Alpha-hydroxy- and alpha-acetoxyphenylethanones and their m- and p-derivatives gave preponderantly the S-configuration products while in the case of the o-derivatives R-alcohol was provided as the major enantiomer. The results of stereoselectivity were discussed.
authors.affiliation: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Wei
authors.forename: G Q
authors.initials: GQ
authors.lastname: Lin
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Li
mesh_terms: D001711:Biotransformation; D005848:Geotrichum / Q000378:metabolism*; D007659:Ketones / Q000737:chemistry / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D007659:Ketones