Malignant melanoma and lymphoproliferative malignancy: is there a shared aetiology?
We report seven patients who developed malignant melanoma either coincident with or before the diagnosis of non-Hodgkin's lymphoma or chronic lymphatic leukaemia. One patient died secondary to leukaemia, and chemotherapy-induced immunosuppression may have contributed to the development of metastatic melanoma in another patient. Immunosuppression, exposure to ultraviolet radiation and genetic factors may result in a host environment that is conducive to the development of both tumours in these patients.
McKenna
D B
DB
Department of Dermatology, Royal Infirmary of Edinburgh, Lauriston Building, Edinburgh EH3 9YW, U.K.
Doherty
V R
VR
McLaren
K M
KM
Hunter
J A
JA
D000368:Aged; D004416:Dysplastic Nevus Syndrome / Q000150:complications; D005260:Female; D006801:Humans; D007107:Immune System / Q000528:radiation effects; D007166:Immunosuppressive Agents / Q000009:adverse effects; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000209:etiology* / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology* / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000209:etiology* / Q000276:immunology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology* / Q000276:immunology; D012878:Skin Neoplasms / Q000209:etiology* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014466:Ultraviolet Rays / Q000009:adverse effects
D007166:Immunosuppressive Agents