title: Design and synthesis of alpha,beta-unsaturated carbonyl compounds as potential ACE inhibitors.
abstract: The alpha,beta-unsaturated amide that is incorporated into the basic structural frame of a simple substrate molecule of angiotensin converting enzyme was found to serve as a Michael acceptor for the catalytic carboxylate of Glu-127, inhibiting the enzyme irreversibly.
authors.affiliation: School of Pharmacy, Ewha Womans University, 120-750, Seoul, South Korea. hypark@mm.ewha.ac.kr
authors.forename: H Y
authors.initials: HY
authors.lastname: Park Choo
authors.forename: K H
authors.initials: KH
authors.lastname: Peak
authors.forename: J
authors.initials: J
authors.lastname: Park
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Chung
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020128:Inhibitory Concentration 50; D007700:Kinetics; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D011392:Proline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; C412577:N-(2-(3-phenyl-2-propenoylamino)propanoyl)proline; D011392:Proline; D007703:Peptidyl-Dipeptidase A