Is nuclear factor-kappaB a good treatment target in brain ischemia/reperfusion injury?
Nuclear factor-kappaB (NF-kappaB) is a transcription factor which resides in its unactivated form in the cytoplasm. Following activation subsequent to cerebral ischemia and reperfusion injury, NF-kappaB acts on genes for cytokines, adhesion molecules, nitric oxide synthase, cyclooxygenase-2, metalloproteinase-9, and perhaps apoptotic genes. These genes have a variety of positive and negative influences on the outcome of brain injury. The effect of manipulation of NF-kappaB needs to be examined critically, as it pertains to these reactive genes.
Carroll
J E
JE
Department of Neurology, Medical College of Georgia, Augusta, USA.
Hess
D C
DC
Howard
E F
EF
Hill
W D
WD
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D018836:Inflammation Mediators / Q000502:physiology; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000502:physiology; D015427:Reperfusion Injury / Q000188:drug therapy*; D013997:Time Factors
D018836:Inflammation Mediators; D016328:NF-kappa B