Endocytosis: why not wait to deubiquitinate?
Deubiquitination by the Fat facets protein - a regulator of photoreceptor differentiation during Drosophila eye development - has been found to activate endocytosis, while ubiquitination inhibits endocytosis. Surprisingly, this is the opposite effect that ubiquitination has on endocytosis of many plasma membrane proteins.
Carthew
R W
RW
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Xu
C
C
D000818:Animals; D004330:Drosophila / Q000254:growth & development / Q000502:physiology; D004705:Endocytosis / Q000502:physiology*; D010450:Endopeptidases / Q000737:chemistry / Q000502:physiology*; D005123:Eye / Q000254:growth & development; D017956:Photoreceptor Cells, Invertebrate / Q000254:growth & development; D015398:Signal Transduction; D014452:Ubiquitins / Q000378:metabolism*
D014452:Ubiquitins; D010450:Endopeptidases; C059237:ubiquitin-Nalpha-protein hydrolase