title: Tissue oxygen pressure during prolonged ischemia of the liver.
abstract: BACKGROUND
  The potential role of hepatovenous back-perfusion in maintaining organ viability of the inflow-occluded liver has been reported with respect to aspects of tissue perfusion and energy metabolism. In the present study, the physiological differences between liver ischemia induced by portal triad clamping (PTC) and that induced by total hepatic vascular exclusion (THVE) were investigated in a porcine disease model, with special reference to changes in tissue oxygen pressure (PtO(2)) of the liver.
  
  
  METHODS
  Twelve female pigs were used for induction of 60 min of normothermic liver ischemia. They were assigned to two groups: a PTC group (n = 6) and a THVE group (n = 6). PtO(2) was measured before, during, and after the ischemic period at two different points in the middle lobe: on the central side close to the hepatovenous confluence and on the peripheral side close to the gallbladder bed.
  
  
  RESULTS
  Although central PtO(2) decreased during ischemia in both groups, PTC group values at 40 and 60 min of ischemia remained significantly higher than THVE group values (60 +/- 28 and 42 +/- 21 mmHg vs 11 +/- 5 and 13 +/- 3 mmHg, respectively; means +/- SD). Peripheral PtO(2) in the PTC group during ischemia was low in comparison to corresponding central PtO(2) values.
  
  
  CONCLUSIONS
  Oxygen supply to the tissue via hepatovenous reflux may contribute to maintaining organ viability under prolonged inflow occlusion of the liver.
authors.affiliation: Department of Surgery I, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita, 879-5593, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hiratsuka
authors.forename: Y I
authors.initials: YI
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Kawano
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Kitano
mesh_terms: D000818:Animals; D004734:Energy Metabolism; D005260:Female; D007511:Ischemia / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000378:metabolism*; D008102:Liver Circulation; D010100:Oxygen / Q000032:analysis; D010101:Oxygen Consumption; D010313:Partial Pressure; D011168:Portal System; D015424:Reperfusion; D013552:Swine; D013997:Time Factors
chemical_list: D010100:Oxygen