Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease.
In patients with Alzheimer's disease, but not in health controls, longitudinal magnetic resonance spectroscopy shows a striking decline in the neuronal marker, N-acetyl aspartate, despite little decline in underlying grey-matter volume.
Adalsteinsson
E
E
Sullivan
E V
EV
Kleinhans
N
N
Spielman
D M
DM
Pfefferbaum
A
A
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000378:metabolism; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D001224:Aspartic Acid; C000179:N-acetylaspartate