Reduction in renal haemodynamics by exaggerated vesicovascular reflex in rats with acute urinary retention.
1. We examined the possibility that a vesicovascular reflex is exaggerated by acute urinary retention, and that the increase in renal vascular resistance caused by this reflex may lead to renal dysfunction. We evaluated the vesicovascular responses to normal micturition (NM, transcystometric condition) and acute urinary retention (isovolumetric condition mimicking complete bladder-outlet obstruction (CBOO) and partial urethral ligation mimicking partial bladder-outlet obstruction (PBOO)) in anaesthetized female Wistar rats. 2. Acute urinary retention due to CBOO or PBOO provoked a prolonged or increased intravesical pressure, an enhancement in both bladder pelvic afferent and bladder pelvic efferent nervous activity, and an elevation in mean arterial blood pressure. 3. Single-unit analysis showed that these vesicovascular reflexes were triggered by activation of low-threshold and high-threshold bladder mechanoreceptors, but not by renal uretropelvic mechanoreceptors. 4. Bladder contraction in CBOO and PBOO conditions and graded increases in bladder volume significantly reduced renal blood flow and cortical microvascular blood flow. The acute urinary retention-induced renal vasoconstriction was mediated by the renal nerve. Renal denervation, but not bilateral ureteral resection, abolished the renal vasoconstriction associated with the vesicovascular reflexes. 5. These findings indicate that exaggerated activation of bladder afferents exerts a positive feedback effect to increase sympathetic outflow to the kidney further, thereby contributing to significant renal vasoconstriction via a renal nerve-dependent mechanism.
Chien
C T
CT
Office for Clinical Research, National Taiwan University Hospital, Taipei, Taiwan.
Yu
H J
HJ
Cheng
Y J
YJ
Wu
M S
MS
Chen
C F
CF
Hsu
S M
SM
D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D004525:Efferent Pathways / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014524:Urethral Obstruction / Q000503:physiopathology; D001743:Urinary Bladder / Q000294:innervation / Q000503:physiopathology; D001745:Urinary Bladder Diseases / Q000503:physiopathology; D016055:Urinary Retention / Q000503:physiopathology*; D014554:Urination / Q000502:physiology*