Effects of vestibular cerebellum lesion on motion sickness in rats.
The importance of the vestibular apparatus in the development of motion sickness is widely accepted, although the role of the vestibular cerebellum remains controversial. We examined the effects of vestibular cerebellum lesion on the development of motion sickness in rats. Rats do not vomit, but the behaviour known as "pica", the eating of non-nutritive substances, such as kaolin, can be used as an index of motion sickness. A 2 h load of hypergravity induced pica in rats, indicating that they suffered from motion sickness. Pica was induced by hypergravity load even after surgical lesion to the bilateral cerebellar flocculus or to the cerebellar vermis. We concluded that the vestibular cerebellum was not essential in the development of motion sickness in rats.
Uno
A
A
Department of Otolaryngology, Suita Municipal Hospital, Osaka, Japan. auno@ent.med.osaka-u.ac.jp
Takeda
N
N
Kitahara
T
T
Sakata
Y
Y
Yamatodani
A
A
Kubo
T
T
D000818:Animals; D002526:Cerebellar Diseases / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D018471:Hypergravity; D008297:Male; D009041:Motion Sickness / Q000209:etiology*; D051381:Rats; D017208:Rats, Wistar; D015837:Vestibular Diseases / Q000150:complications* / Q000503:physiopathology / Q000601:surgery