title: Reorganization of the motor cortex in a patient with congenital hemiparesis and mirror movements.
abstract: Abnormal branching of corticospinal fibers from the unaffected motor cortex is responsible for mirror movements in patients with congenital hemiparesis, but it is unknown which mechanisms enable these patients to lateralize motor activity. Using multiunit electromyographic analysis and transcranial magnetic stimulation, the authors provide evidence for nonbranched crossed and uncrossed corticospinal projections and intracortical inhibition of the mirror hand. They propose that this remarkable reorganization of the unaffected motor cortex helps these patients to reduce mirror movements.
authors.affiliation: Unit of Neurology, Santa Maria Nuova Hospital, Florence, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cincotta
authors.forename: A
authors.initials: A
authors.lastname: Borgheresi
authors.forename: P
authors.initials: P
authors.lastname: Liotta
authors.forename: A
authors.initials: A
authors.lastname: Montigiani
authors.forename: E
authors.initials: E
authors.lastname: Marin
authors.forename: G
authors.initials: G
authors.lastname: Zaccara
authors.forename: U
authors.initials: U
authors.lastname: Ziemann
mesh_terms: D000328:Adult; D002547:Cerebral Palsy / Q000473:pathology / Q000503:physiopathology*; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008280:Magnetics; D008297:Male; D009044:Motor Cortex / Q000473:pathology / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010291:Paresis / Q000151:congenital* / Q000473:pathology / Q000503:physiopathology*; D011712:Pyramidal Tracts / Q000473:pathology / Q000502:physiology