title: Ontogeny: the evolution of an oocyte.
abstract: The physiology of oocyte development, maturation, and selection forms the basis for understanding ovarian follicle dynamics, reproductive function and ovulation induction. The number of ovarian follicles with which women are invested from birth and the rate of decline determine their reproductive lifespan. The processes of atresia and apoptosis constantly deplete this finite store. The initiation of follicle growth involves complex chemical signaling and ensures that a cohort of follicles is prepared for recruitment monthly. The effects of gonadotrophins, autocrine signals, and the degree of vascularization further determine dominance and the selection of an oocyte for ovulation.
authors.affiliation: Department of Obstetrics and Gynecology, Singapore General Hospital, Singapore.
authors.forename: C
authors.initials: C
authors.lastname: Yap
mesh_terms: D005260:Female; D006801:Humans; D009865:Oocytes / Q000254:growth & development*; D006080:Ovarian Follicle / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*