title: A model for ZnII-containing-beta-lactamase: synthesis, X-ray crystal structure of a zinc(II) complex bearing thiol group and hydrolysis of phosphate diester.
abstract: A novel N3S1 typed tripodal ligand bearing an SH group, N-(mercaptoethyl)-di(2-pyridylmethyl)amine, DPASH, was prepared and its zinc(II) complex, [ZnII(DPAS)Cl], was structurally characterized by X-ray crystallography. [ZnII(DPAS)Cl] promoted hydrolysis of sodium bis(p-nitrophenyl)hydrogenphosphate), BNP-.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kurosaki
authors.forename: T
authors.initials: T
authors.lastname: Tawada
authors.forename: S
authors.initials: S
authors.lastname: Kawasoe
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: M
authors.initials: M
authors.lastname: Goto
mesh_terms: D018360:Crystallography, X-Ray; D004952:Esters; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D008956:Models, Chemical; D011487:Protein Conformation; D013438:Sulfhydryl Compounds; D015032:Zinc / Q000737:chemistry*; D001618:beta-Lactamases / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D004952:Esters; D013438:Sulfhydryl Compounds; D001618:beta-Lactamases; D015032:Zinc