In vitro bioactivity and gentamicin release from glass-polymer-antibiotic composites.
Composite materials have been prepared from bioactive glass powders in the SiO(2)-CaO-P(2)O(5) system, a biodegradable polymer [poly(L-lactic acid) (PLA)], a biostable polymer [polymethylmethacrylate (PMMA)], and an antibiotic [gentamicin]. The purpose of such composites is to obtain implantable materials that are able to lead to bone growth and also can, at the most critical inflammation-infection step, release an antibiotic. X-ray diffraction, scanning electron microscopy, X-ray energy dispersive spectroscopy, and FTIR analyses after different soaking periods in SBF demonstrated the growth of an apatite-like layer on the composite surface. Therefore the bioactive glass-polymer-antibiotic combination used in this work does not inhibit the glass bioactivity. The release of gentamicin after a soaking of the materials in SBF was followed by UV-visible spectroscopy. A fast initial release during the first 10 h of soaking, followed by a controlled release of the drug was observed.
Ragel
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Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Vallet-Regí
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M
D001031:Apatites; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000187:drug effects / Q000601:surgery; D016503:Drug Delivery Systems; D004343:Drug Implants; D005839:Gentamicins / Q000008:administration & dosage*; D005898:Glass; D006801:Humans; D066298:In Vitro Techniques; D019344:Lactic Acid; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers; D019904:Polymethyl Methacrylate; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D001031:Apatites; D001672:Biocompatible Materials; D004343:Drug Implants; D005839:Gentamicins; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D019904:Polymethyl Methacrylate