Gdf16, a novel member of the growth/differentiation factor subgroup of the TGF-beta superfamily, is expressed in the hindbrain and epibranchial placodes.
We have isolated and characterized the developmental expression of Xenopus gdf16, a novel member of the growth/differentiation factor (gdf) gene family. The gdf16 gene encodes a pre-proprotein of 413 amino acids and a mature peptide of 122 amino acids. Gdf16 is most closely related to the zebrafish genes dynamo and radar, but exhibits a completely different expression pattern. Gene expression is detected at early tailbud (stage 25) in the first two epibranchial placodes and in a hindbrain-specific domain. As development proceeds, the gene is expressed in all the epibranchial placodes, the hindbrain, and the diencephalon.
Vokes
S A
SA
Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, P.O. Box 245044, Tucson, AZ 85724, USA.
Krieg
P A
PA
D000595:Amino Acid Sequence; D000818:Animals; D018507:Gene Expression Regulation, Developmental; D055412:Growth Differentiation Factors; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009420:Nervous System / Q000196:embryology*; D016415:Sequence Alignment; D016212:Transforming Growth Factor beta / Q000235:genetics*; D014981:Xenopus / Q000196:embryology* / Q000502:physiology*; D029867:Xenopus Proteins
C415354:GDF7 protein, Xenopus; D055412:Growth Differentiation Factors; D009419:Nerve Tissue Proteins; D016212:Transforming Growth Factor beta; D029867:Xenopus Proteins