title: A magnetic resonance-compatible experimental set-up for hyperthermia studies.
abstract: This study presents the development and testing of an experimental set-up for simultaneous measurements of pH (intracellular by MR and extracellular by fibre-optic pH meter), tumour bio-energetics (by MR), and core/tumour temperatures (by thermocouples) in tumour-bearing mice. Potential sources of measurement errors when using these techniques concurrently in an MR set-up are discussed. Emphasis is placed on simple practical solutions to these problems.
authors.affiliation: Clinical Oncology and Radiotherapeutics Unit, Cambridge University School of Clinical Medicine, UK. ramaj@medinst.ernet.in
authors.forename: R
authors.initials: R
authors.lastname: Jayasundar
authors.forename: L D
authors.initials: LD
authors.lastname: Hall
authors.forename: N M
authors.initials: NM
authors.lastname: Bleehen
mesh_terms: D000818:Animals; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging; D051379:Mice; D009374:Neoplasms, Experimental / Q000503:physiopathology*; D013821:Thermometers