[The use of cycloferon in the therapy of experimental herpetic keratitis].
The cycloferon efficacy was investigated in the treatment of experimental herpesvirus kerato-conjunctivitis in rabbits. The model was demonstrated to reflect the main aspects of herpesvirus eye lesions in humans. Cycloferon application similarly to that of known interferon inducer poludan has been shown to enhance processes of inflammation and subsequent regeneration of eye tissues as well as to decrease mortality of animals due to the generalization of infection.
Sukhinin
V P
VP
Influenza Research Institute, RAMS, St. Petersburg.
Pleskov
V M
VM
Zarubaev
V V
VV
Slita
A V
AV
Pestrinskaia
E A
EA
Brzheskiĭ
V V
VV
Kovalenko
A L
AL
Ershov
F I
FI
D000166:Acridines / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D007369:Interferon Inducers / Q000627:therapeutic use*; D015863:Iridocyclitis / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000821:virology; D016849:Keratitis, Herpetic / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D011131:Polyribonucleotides / Q000627:therapeutic use; D011817:Rabbits; D018139:Simplexvirus / Q000302:isolation & purification; D013997:Time Factors
D000166:Acridines; D007369:Interferon Inducers; D011131:Polyribonucleotides; C044366:poludan; C026430:10-carboxymethyl-9-acridanone