Effect of Picrorrhiza kurroa extract on transplanted tumours and chemical carcinogenesis in mice.
Anti-tumour and anti-carcinogenic activity of Picrorrhiza kurroa extract were studied in mice. Administration of 20-methylcholanthrene (20 MC) produced 100% induction of sarcoma in control mice, whereas the tumour incidence and tumour related deaths were significantly inhibited by the oral administration of P. kurroa extract 150 and 750 mg/kg body weight, respectively. The extract was also found to reduce the volume of transplanted solid tumours induced by Dalton's lymphoma ascites (DLA) tumour cell lines and increased the life span of ascites tumour bearing mice. P. kurroa extract inhibited yeast topoisomerase I and II enzyme activity when tested on Saccharomyces cerevisiae mutant cell cultures. The extract did not inhibit the enzyme involved in the activation of carcinogen and the cell cycle regulatory enzyme cdc2 kinase.
Joy
K L
KL
Amala Cancer Research Centre, Thrissur 680 553, Kerala, Amala Nagar, India.
Rajeshkumar
N V
NV
Kuttan
G
G
Kuttan
R
R
D000815:Aniline Hydroxylase / Q000037:antagonists & inhibitors; D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors; D002273:Carcinogens / Q000633:toxicity; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D007194:India; D008297:Male; D008748:Methylcholanthrene / Q000633:toxicity; D051379:Mice; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012513:Sarcoma, Experimental / Q000188:drug therapy; D016019:Survival Analysis; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D002273:Carcinogens; D004791:Enzyme Inhibitors; D010936:Plant Extracts; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D008748:Methylcholanthrene; D000815:Aniline Hydroxylase; D016203:CDC2 Protein Kinase