[The biomechanical function of the heart and its adrenergic regulation after long-term gamma radiation exposure].
The study of heart isolated by Langendorf's method has shown that the prolonged gamma irradiation of rats with 1.0 Gy dose (2.8 x 10(-7) Gy/sec) causes the decrease in contraction and relaxation ability, of myocardium, reduces functional response of heart to the stimulation of beta-adrenergic receptors, and increases of myocardium reaction to the stimulation of alpha-adrenergic receptors.
Lobanok
L M
LM
Institute of Radiobiology, National Academy of Science of Belarus, Minsk. irb@radbio.bas-net.by
Antonenko
A N
AN
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D001696:Biomechanical Phenomena; D004305:Dose-Response Relationship, Drug; D005260:Female; D005720:Gamma Rays; D006321:Heart / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects / Q000528:radiation effects; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D013268:Stimulation, Chemical; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D011941:Receptors, Adrenergic; D010656:Phenylephrine; D007545:Isoproterenol