title: Aspiration and imprint cytopathology of thyroid carcinoma associated with familial adenomatous polyposis.
abstract: Thyroid carcinomas occur in association with familial adenomatous polyposis (FAP), and some are the first symptom of FAP. Although several histological features have been reported, the cytopathology of FAP-associated thyroid carcinoma has not yet been described. We report on two cases of FAP-associated thyroid carcinomas diagnosed by fine-needle aspiration biopsy and one case imprinted after resection. All 3 patients belonged to the same family, and thyroid carcinoma was the first symptom of the proband. Cytological features include fascicular or whorl formation of spindle cells with papillary, follicular, and/or solid architectures, in addition to the typical features of papillary carcinoma. The cytological features of FAP-associated thyroid carcinomas are characteristic and may suggest FAP.
authors.affiliation: Department of Pathology, Jichi Medical School, Minamikawachi-machi, Kawachi-gun, Tochigi, Japan. jmchong-tky@umin.ac.jp
authors.forename: J
authors.initials: J
authors.lastname: Chong
authors.forename: N
authors.initials: N
authors.lastname: Koshiishi
authors.forename: K
authors.initials: K
authors.lastname: Kurihara
authors.forename: S
authors.initials: S
authors.lastname: Kubono
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Fukayama
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000473:pathology*; D000293:Adolescent; D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002648:Child; D005260:Female; D017491:Genes, APC; D006801:Humans; D009154:Mutation; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery