title: Use of calcitonin for the treatment of an odontoid fracture. Case report.
abstract: The authors report on the efficacy of nonsurgical treatment of an older patient with a fractured odontoid process. The patient, an 85-year-old woman, had multiple medical problems that put her at an increased surgery-related risk. Therefore, an alternative approach was elected, including immobilization with a Philadelphia collar and the provision of calcitonin nasal spray. Bone union and clinical recovery were achieved within 8 weeks of initiating the nasal calcitonin therapy (12 weeks postinjury). Considering the patient's age, comorbidities, and the severity of the fracture, the recovery period was unusually short. The authors believe that calcitonin played a pivotal role in the healing process of the fractured odontoid bone. There is no question that the fusion in this patient could be unrelated to the medical therapy. This description of one patient, as well as the lack of a large randomized study, precludes any scientific conclusions. Nevertheless, the authors believe that the development of a successful fusion in this high-risk patient should be reported as an observation that merits confirmation and study. The authors also discuss the physiological effects of calcitonin and the research and clinical experience with this hormone in different conditions affecting bone.
authors.affiliation: Department of Neurosurgery, University of Cincinnati College of Medicine, Ohio, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Darakchiev
authors.forename: R V
authors.initials: RV
authors.lastname: Bulas
authors.forename: S B
authors.initials: SB
authors.lastname: Dunsker
mesh_terms: D000281:Administration, Intranasal; D000368:Aged; D000369:Aged, 80 and over; D001915:Braces; D002116:Calcitonin / Q000008:administration & dosage / Q000627:therapeutic use*; D004194:Disease; D005260:Female; D017102:Fracture Healing; D006801:Humans; D007103:Immobilization; D004204:Joint Dislocations / Q000188:drug therapy / Q000628:therapy; D009809:Odontoid Process / Q000293:injuries*; D016103:Spinal Fractures / Q000188:drug therapy* / Q000628:therapy
chemical_list: D002116:Calcitonin