Serum tryptase and the laboratory diagnosis of systemic mastocytosis.
Total tryptase levels of 20 ng/mL or higher in a baseline serum sample when the ratio of total to beta-tryptase is 20 or greater strongly suggest underlying systemic mastocytosis. Whether these criteria prove to be more sensitive than a bone marrow biopsy will require further study. Although the absolute level of total tryptase does not predict disease severity, it may provide a practical method for assessing the efficacy of therapeutic interventions designed to reduce the mast cell burden.
Schwartz
L B
LB
Division of Rheumatology, Allergy, and Immunology, Virginia Commonwealth University, Richmond, USA. lschwart@hsc.vcu.edu
Irani
A M
AM
D000707:Anaphylaxis / Q000201:enzymology; D000818:Animals; D015415:Biomarkers; D004790:Enzyme Induction; D004792:Enzyme Precursors / Q000235:genetics / Q000378:metabolism; D005796:Genes; D006801:Humans; D007527:Isoenzymes / Q000097:blood* / Q000235:genetics; D008322:Mammals / Q000378:metabolism; D008407:Mast Cells / Q000145:classification / Q000201:enzymology; D008415:Mastocytosis / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics; D011180:Postmortem Changes; D011499:Protein Processing, Post-Translational; D012189:Retrospective Studies; D012697:Serine Endopeptidases / Q000097:blood* / Q000235:genetics; D013398:Sudden Infant Death / Q000209:etiology; D053802:Tryptases
D015415:Biomarkers; D004792:Enzyme Precursors; D007527:Isoenzymes; D012697:Serine Endopeptidases; D053802:Tryptases