Thienothiadiazine 2,2-dioxide acyclonucleosides: synthesis and antiviral activity.
The synthesis of acyclonucleosides derived from thieno[3,2-c] and thieno[2,3-c][1,2,6]thiadiazine 2,2-dioxides was achieved following the silylation method. Lipase-mediated methodology was employed for deprotection of the acyclic moieties. The antiviral effects were determined against a broad spectrum of viruses, including cytomegalovirus (CMV) and varicella zoster virus (VZV). Only minor antiviral activity against VZV was observed for those acyclonucleosides carrying a benzyl group.
Martinez
A
A
Instituto de Quimica Medica (CSIC), Madrid, Spain. iqmam06@pinar2.csic.es
Esteban
A
A
Castro
A
A
Gil
C
C
Conde
S
S
Andrei
G
G
Snoeck
R
R
Balzarini
J
J
De Clercq
E
E
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D003587:Cytomegalovirus / Q000187:drug effects; D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005347:Fibroblasts / Q000821:virology; D006678:HIV / Q000187:drug effects; D014645:Herpesvirus 3, Human / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013829:Thiadiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents; D013829:Thiadiazines; D003596:Cytosine