Update on histamine as a mediator of inflammation.
Histamine is an important mediator and regulator of inflammation. Histamine acts via H1, H2, and H3 receptors that are functionally coupled to G-proteins and histamine release is regulated by cytokines that act as histamine release factors. Histamine suppresses the immune response and deviates the immune response toward the Th2 pathway.
Weltman
J K
JK
Brown University School of Medicine, Fall River, Massachusetts 02720, USA.
D000818:Animals; D006632:Histamine / Q000378:metabolism*; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism*; D011968:Receptors, Histamine / Q000378:metabolism
D018836:Inflammation Mediators; D011968:Receptors, Histamine; D006632:Histamine