Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping.
We report the chromosomal localization in both mouse and human of a novel G-protein-coupled receptor, GPR48, which resembles glycoprotein hormone receptors, that may be implicated in Wilms tumor deletion syndromes such as WAGR. This receptor forms a novel sub-family of glycoprotein hormone-like GPCRs. We have mapped this receptor to human chromosome 11p14-->p13 by several approaches, including radiation hybrid and interspecific backcross mapping, and show that GPR48 is close to BDNF. This data differs from the recently published mapping of LGR4 (5q34-->q35.1) (Hsu et al., 1998). Additionally, we show that Gpr48 and Bdnf are tightly linked on mouse chromosome 2, in a region with conserved synteny to human 11p14-->p13.
Loh
E D
ED
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA.
Broussard
S R
SR
Liu
Q
Q
Copeland
N G
NG
Gilbert
D J
DJ
Jenkins
N A
NA
Kolakowski
L F
LF
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011956:Receptors, Cell Surface / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled
D019208:Brain-Derived Neurotrophic Factor; C411562:LGR4 protein, human; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled