title: The platelet alpha2-integrin (GPIa) nucleotide-807 polymorphism is not associated with a risk for maternal-fetal human platelet antigen-5 incompatibility.
abstract: Alloimmunization against human platelet antigen (HPA)-5 may lead to neonatal alloimmune thrombocytopenia. The HPA-5 dimorphism is expressed on the platelet alpha2beta1 integrin. The density of this receptor is associated with another dimorphism of the 2beta1 integrin (nucleotide-807C/T). We hypothesized that anti-HPA-5b-induced neonatal thrombocytopenia is more likely to occur if the receptor is expressed at high than at low levels. Among 933 mother-child pairs, we identified 79 HPA-5aa mothers giving birth to a HPA-Sab offspring. Seventeen mothers had HPA-5b antibodies, but the offspring had a normal platelet count. We genotyped the offspring and mothers for the alpha2-807C/T dimorphism to evaluate its relationship to antibody formation. There was no difference between the frequency of the 807C/T dimorphism among children delivered from alloimmunized mothers and those from mothers without antibodies (P>0.3). The frequency of the 807C/T dimorphism was not different in the two maternal groups. In three maternal-fetal incompatibilities, we observed at delivery normal platelet counts of platelets typed HPA-5b-alpha2807T, despite increasing maternal antibody titers during the pregnancy. Our data do not support the hypothesis that the 807C/T dimorphism in the HPA-5ab children is a predisposing factor to either elicit alloimmunization against HPA-5b or for neonatal alloimmune thrombocytopenia.
authors.affiliation: Clinic for Blood Group Serology, University of Vienna, Austria. simon.panzer@univie.ac.at
authors.forename: S
authors.initials: S
authors.lastname: Panzer
authors.forename: M
authors.initials: M
authors.lastname: Janisiw
authors.forename: G
authors.initials: G
authors.lastname: Fischer
authors.forename: B
authors.initials: B
authors.lastname: Jilma
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D016023:Integrins / Q000235:genetics* / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D038981:Receptors, Collagen; D012307:Risk Factors
chemical_list: C071092:5a alloantigen, human; D016824:Antigens, Human Platelet; D016023:Integrins; D007519:Isoantigens; D038981:Receptors, Collagen