Rac and roll over the corpses.
A genetic pathway controlling the removal of apoptotic corpses has now been identified in the nematode. Mammalian homologs of the components of this pathway are already known to have key roles in cell motility and integrin-mediated signaling, suggesting that the three processes are mechanistically related.
Caron
E
E
MRC-LMCB, University College London, UK. e.caron@ucl.ac.uk
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000235:genetics / Q000502:physiology; D016923:Cell Death / Q000235:genetics; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D010587:Phagocytosis; D011494:Protein Kinases / Q000235:genetics / Q000502:physiology; D011518:Proto-Oncogene Proteins; D050737:Proto-Oncogene Proteins c-crk; D020764:cdc42 GTP-Binding Protein / Q000502:physiology; D020744:rac GTP-Binding Proteins / Q000502:physiology
D015801:Helminth Proteins; D011518:Proto-Oncogene Proteins; D050737:Proto-Oncogene Proteins c-crk; D011494:Protein Kinases; D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins