Intrathecal IgG synthesis and autoantibody-secreting cells in multiple sclerosis.
We studied intrathecal IgG synthesis and autoantibody-secreting cells in 148 patients with possible onset symptoms of MS (POSMS) or clinically definite MS (CDMS). In POSMS intrathecal synthesis of IgG oligoclonal bands and abnormalities on T2-weighted magnetic resonance imaging were associated but the former were more prevalent. The cerebrospinal fluid (CSF) leukocyte count and the number of anti-protelipid protein antibody-secreting cells in cerebrospinal fluid (CSF) correlated with disease activity in POSMS. Intrathecal IgG synthesis levels and the number of anti-myelin basic protein antibody-secreting cells in CSF correlated with disease activity in CDMS. Our results support recent reports of pathogenetic heterogeneity and a pathogenetic role of the antibody response in MS.
Sellebjerg
F
F
Department of Neurology, University of Copenhagen, Glostrup Hospital, 57 Nordre Ringvej, DK-2600 Glostrup, Copenhagen, Denmark. sellebjerg@dadlnet.dk
Jensen
C V
CV
Christiansen
M
M
D000328:Adult; D000918:Antibody Specificity; D001323:Autoantibodies / Q000096:biosynthesis / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000378:metabolism; D007958:Leukocyte Count; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid / Q000276:immunology; D018991:Myelin Proteolipid Protein / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D004676:Myelin Basic Protein; D018991:Myelin Proteolipid Protein