title: Bupivacaine for postoperative pain relief at the iliac crest bone graft harvest site.
abstract: An inevitable side effect of iliac crest bone graft harvesting is postoperative pain at the donor site. Bupivacaine hydrochloride is a long-acting local anesthetic that is clinically effective for approximately 8 hours. The present study was undertaken to assess postoperative pain relief with locally injected bupivacaine at the iliac crest bone graft harvest site. Pain relief with locally injected bupivacaine or saline at the iliac bone harvest site using an indwelling catheter was studied in 13 patients in a prospective, double-blind, crossover study. Twelve patients had cervical diskectomy and arthrodesis with autograft and one patient had a triple arthrodesis of the foot. There were no statistically significant differences between patients given bupivacaine and patients given saline with respect to pain relief ratings and hip-pain ratings at rest and motion during the first 24-hour postoperative period and the second 24-hour postoperative period (Mann-Whitney test). The single diabetic patient who had a triple arthrodesis developed a wound infection at the catheter placement site. The number of patients was too small to draw conclusions about the differences in pain-medication requirements between patients undergoing single versus multiple diskectomies and fusions. In view of the lack of improvement in pain relief and the risk of infection, local administration of bupivacaine at the iliac bone harvest site is not recommended in its present form for postoperative analgesia.
authors.affiliation: Hospital for Joint Diseases Orthopaedic Institute, New York, New York, USA.
authors.forename: R
authors.initials: R
authors.lastname: Puri
authors.forename: R
authors.initials: R
authors.lastname: Moskovich
authors.forename: P
authors.initials: P
authors.lastname: Gusmorino
authors.forename: S
authors.initials: S
authors.lastname: Shott
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000627:therapeutic use*; D016025:Bone Transplantation; D002045:Bupivacaine / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007085:Ilium / Q000601:surgery* / Q000637:transplantation; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D011182:Postoperative Care; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine