Enhanced pulmonary pathology in cotton rats upon challenge after immunization with inactivated parainfluenza virus 3 vaccines.
Vaccine-induced potentiation was studied in cotton rats immunized with formalin-inactivated human parainfluenza type 3, ultraviolet light-inactivated virus, or infection with live virus. Immunized animals and unimmunized controls were later challenged by intranasal inoculation of live virus and evaluated for pulmonary pathology 4 days later. Animals immunized with either of the inactivated vaccines developed marked peribronchiolitis, perivasculitis, and an alveolar cellular infiltration much more severe than seen in animals infected previously, or in unmanipulated but challenged animals. Disease enhancement after immunization with killed virus is thus a characteristic of a member of each of three genera of the family, Paramyxoviridae, and is not restricted to immunization with formalin-inactivated virus.
Ottolini
M G
MG
Department of Pediatrics, Uniformed Services University of the Health Sciences, F. Edward Hébert School of Medicine, Bethesda, Maryland 20814-4799, USA. mottolini@usuhs.mil
Porter
D D
DD
Hemming
V G
VG
Prince
G A
GA
D000818:Animals; D004195:Disease Models, Animal; D005557:Formaldehyde; D006801:Humans; D008168:Lung / Q000473:pathology*; D022241:Parainfluenza Vaccines / Q000276:immunology*; D010224:Parainfluenza Virus 3, Human / Q000276:immunology*; D010253:Respirovirus Infections / Q000276:immunology / Q000473:pathology* / Q000821:virology; D016205:Sigmodontinae; D014611:Vaccination; D015164:Vaccines, Inactivated / Q000276:immunology
D022241:Parainfluenza Vaccines; D015164:Vaccines, Inactivated; D005557:Formaldehyde