Altered thiol status in preeclampsia.
Thirty preeclamptic, 30 normotensive pregnant and 25 healthy nonpregnant women were analyzed with regard to the antioxidant system (thiols and superoxide dismutase, SOD). In preeclampsia both plasma and lysate thiol levels were significantly lower compared to controls (p < 0.001). SOD levels were higher in normotensive pregnant women, but were lower in preeclamptic compared to nonpregnant women. This finding of antioxidant changes in the red blood cell suggests that red cell dysfunction is fundamental in the development of preeclampsia, and similar alterations in the balance of the thiol could be present across the endothelial cell membrane.
Kharb
S
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Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, India.
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013438:Sulfhydryl Compounds / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D013438:Sulfhydryl Compounds; D013482:Superoxide Dismutase