Speciation of insulin-mimetic VO(IV)-containing drugs in blood serum.
The biospeciations of three potential insulin-mimetic VO(IV) compounds, VO(maltolate)2, VO(picolinate)2 and VO(6-Me-picolinate)2, in blood serum were assessed via modelling calculations, using the stability constants reported in the literature for the binary insulin-mimetic complexes and their ternary complexes formed with the most important low molecular mass binders in the serum: oxalic acid, lactic acid, citric acid and phosphate. The binding capabilities of two high molecular mass serum proteins, albumin and transferrin, were also taken into account.
Kiss
T
T
Department of Inorganic and Analytical Chemistry, József Attila University, Szeged, Hungary. tkiss@chem.u-szeged.hu
Kiss
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E
Garribba
E
E
Sakurai
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H
D019343:Citric Acid / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000494:pharmacology; D019344:Lactic Acid / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry; D010848:Picolinic Acids / Q000737:chemistry; D012709:Serum Albumin / Q000378:metabolism; D014168:Transferrin / Q000378:metabolism; D014638:Vanadates / Q000097:blood*
D007328:Insulin; D008024:Ligands; D010710:Phosphates; D010848:Picolinic Acids; D012709:Serum Albumin; D014168:Transferrin; D019343:Citric Acid; D019344:Lactic Acid; D014638:Vanadates