title: Peptide T does not ameliorate experimental autoimmune encephalomyelitis (EAE) in Lewis rats.
abstract: Peptide T has been shown to inhibit T cell activation and cytokine production and function. Moreover, it has been reported to be a safe treatment in humans. We have studied the ability of peptide T to prevent or ameliorate EAE in Lewis rats. Peptide T was administered subcutaneously at different doses and phases of the disease according to several treatment protocols, but we could not observe a consistent effect of peptide T ameliorating the disease. Lymph node cell proliferation and IL-4 and interferon-gamma production were also studied. We conclude that peptide T neither prevents nor ameliorates EAE in Lewis rats.
authors.affiliation: Unitat de Neuroimmunologia Clínica, Department of Neurology, Hospital General Vall d'Hebron, Universitat Autònoma de Barcelona, Universitat Politècnica de Catalunya, ETSEIB, Barcelona, Spain. isaez@hg.vhebron.es
authors.forename: I
authors.initials: I
authors.lastname: Sáez-Torres
authors.forename: C
authors.initials: C
authors.lastname: Espejo
authors.forename: J J
authors.initials: JJ
authors.lastname: Pérez
authors.forename: N
authors.initials: N
authors.lastname: Acarín
authors.forename: X
authors.initials: X
authors.lastname: Montalban
authors.forename: E M
authors.initials: EM
authors.lastname: Martínez-Cáceres
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D005260:Female; D006168:Guinea Pigs; D007371:Interferon-gamma / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D015717:Peptide T / Q000008:administration & dosage / Q000627:therapeutic use*; D010865:Pilot Projects; D051381:Rats; D011917:Rats, Inbred Lew
chemical_list: D015717:Peptide T; D015847:Interleukin-4; D007371:Interferon-gamma