The pathology of chronic asthma.
Our understanding of the pathophysiology of asthma has undergone great advances in the past decade, particularly with the recognition of cytokines and the roles they may take in orchestrating the local immune response. With this information, it has been possible to target new therapeutic entities such as cytokine or chemokine receptors. Eosinophils and T lymphocytes have a special place in the inflammatory and structural alterations contributing to the asthmatic diathesis. It is possible that phenotype subsets of these cells exist and they hold the key to perpetuation of immunologic and physiologic abnormalities in asthma.
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Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Minshall
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Hamid
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D001249:Asthma / Q000473:pathology* / Q000503:physiopathology*; D001402:B-Lymphocytes / Q000502:physiology; D001491:Basophils / Q000502:physiology; D002908:Chronic Disease; D016207:Cytokines / Q000502:physiology; D004804:Eosinophils / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation; D008407:Mast Cells / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
D016207:Cytokines