title: Effects of intestinal endotoxemia on pathogenesis of liver injury induced by thioacetamide.
abstract: OBJECTIVE
  To study the effect of intestinal endotoxemia on pathogenesis of liver injury induced by thioacetamide (TAA).
  
  
  METHODS
  Twenty-six male Wistar rats were divided into 4 groups, namely: normally control group (N), colectomy control group (C), colectomy+TAA group (C+T), TAA group (T). The changes in plasma biochemistry were measured.
  
  
  RESULTS
  Plasma endotoxin levels were significantly higher in TAA group than normally control group. Plasma endotoxin levels in colectomy+TAA group were close to that of normally control group. Plasma ALT activity in colectomy+TAA group increased significantly compared with that of normal control group, but markedly lower than that in TAA group. Plasma endotoxin levels were positively correlated to ALT activity in T and C+T groups (r=0. 985, P<0.01).
  
  
  CONCLUSIONS
  TAA itself has a deleterious effect to hepatic cells. It can also induce intestinal endotoxemia in which the liver injury is more inclined to occur and severe.
authors.affiliation: The Institute for Hepatology, Shanxi Medical University, Taiyuan 030001, China.
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: D
authors.initials: D
authors.lastname: Han
authors.forename: D
authors.initials: D
authors.lastname: Ren
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019446:Endotoxemia / Q000150:complications*; D007422:Intestines / Q000382:microbiology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide / Q000633:toxicity*
chemical_list: D013853:Thioacetamide; D000410:Alanine Transaminase