title: [Congenital malaria due to Plasmodium falciparum and Plasmodium malariae].
abstract: Increasing tourism and growing numbers of immigrants from malaria-endemic countries are leading to a higher importation rate of rare tropical disorders in European countries. We describe, to the best of our knowledge, the first case of connatal malaria in Austria. The patient is the first child of a 24 year old mother who was born in Ghana and immigrated to Austria one and a half years before delivery. She did not stay in an endemic region during this period and did not show fever or any other signs of malaria. The boy was healthy for the first six weeks of his life. In the 8th week of life he was admitted to our hospital due to persistent fever of unknown origin. On physical examination he showed only mild splenomegaly. Routine laboratory testing revealed mild hemolytic anemia with a hemoglobin value of 8.3 g/l. In the blood smear Plasmodium falciparum and Plasmodium malariae were detected. Oral therapy with quinine hydrochloride was successful and blood smears became negative for Plasmodia within 6 days. This case shows that congenital malaria can occur in children of clinically healthy women who were born in malaria-endemic areas even one and a half year after they have immigrated to non-endemic regions.
authors.affiliation: Universitätsklinik für Kinder- und Jugendheilkunde Graz. werner.zenz@kfunigraz.ac.at
authors.forename: W
authors.initials: W
authors.lastname: Zenz
authors.forename: M
authors.initials: M
authors.lastname: Trop
authors.forename: H
authors.initials: H
authors.lastname: Kollaritsch
authors.forename: F
authors.initials: F
authors.lastname: Reinthaler
mesh_terms: D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001317:Austria / Q000453:epidemiology; D005260:Female; D005335:Fever of Unknown Origin / Q000469:parasitology; D005869:Ghana / Q000208:ethnology; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008288:Malaria / Q000151:congenital* / Q000175:diagnosis / Q000469:parasitology* / Q000628:therapy; D016778:Malaria, Falciparum / Q000151:congenital / Q000175:diagnosis; D008297:Male; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D010965:Plasmodium malariae / Q000302:isolation & purification*; D011803:Quinine / Q000627:therapeutic use; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D011803:Quinine