title: Disseminated and recurrent sarcoid-like granulomatous panniculitis due to bovine collagen injection.
abstract: Three to five percent of patients treated with injectable collagen implants have adverse local reactions. Systemic signs or symptoms are infrequent. We describe the case of a 53-year-old woman who developed local and general complaints 2 months after receiving two collagen injections in both nasolabial folds. She presented asthenia, malaise, polyarthralgia and inflammatory nodular panniculitis in the places of injection as well as on the forearms and lower extremities. Skin testing was compatible with hypersensitivity to collagen. This case raises the question as to whether the injection of animal-derived collagen induces manifestations similar to those observed in connective autoimmune diseases or human adjuvant disease.
authors.affiliation: Department of Internal Medicine, Institut Universitari Dexeus de Barcelona, Spain.
authors.forename: M I
authors.initials: MI
authors.lastname: García-Domingo
authors.forename: J
authors.initials: J
authors.lastname: Alijotas-Reig
authors.forename: A
authors.initials: A
authors.lastname: Cisteró-Bahima
authors.forename: F
authors.initials: F
authors.lastname: Tresserra
authors.forename: E
authors.initials: E
authors.lastname: Enrique
mesh_terms: D000818:Animals; D018771:Arthralgia / Q000139:chemically induced / Q000276:immunology; D002417:Cattle; D003094:Collagen / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000276:immunology; D005549:Foreign-Body Reaction / Q000139:chemically induced* / Q000276:immunology; D006099:Granuloma / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000276:immunology; D007279:Injections, Subcutaneous; D008046:Lip; D008875:Middle Aged; D009666:Nose; D015434:Panniculitis / Q000139:chemically induced* / Q000276:immunology; D017445:Skin Diseases, Vascular / Q000139:chemically induced / Q000276:immunology; D012882:Skin Tests; D013518:Surgery, Plastic / Q000009:adverse effects*
chemical_list: D003094:Collagen