Krukenberg tumor: a clinico-pathological study of 15 cases.
Krukenberg tumor clinically mimics primary ovarian cancer. We report a series of 15 cases of Krukenberg tumor. The patients' age range from 13 to 71 years. Most ovarian tumors (14/15) were bilateral. A primary digestive tumor was diagnosed pre-operatively in 3 cases, per-operatively in 3 cases and post-operatively in 4 cases. No primary tumor was identified in the 5 other cases. Histological diagnosis of Krukenberg tumor is usually easy either on paraffin or frozen sections. Mucin stains are helpful. Two main histological types were found in our series : the classic form with sarcoma-like storiform tumoral stroma and an alternative cellular-acellular pattern. Mucinous carcinoid was microscopically challenged in two cases. Most patients died within 2 years (median survival 14 months). Nor surgery, neither chemotherapy is efficient but bilateral oophorectomy should be proposed in post-menopausal women with gastric linitis removed surgically.
Mrad
K
K
Département de Pathologie, Institut Gustave Roussy, Villejuif, France.
Morice
P
P
Fabre
A
A
Pautier
P
P
Lhommé
C
C
Duvillard
P
P
Sabourin
J C
JC
D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007725:Krukenberg Tumor / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D010052:Ovariectomy; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy