Synthesis and NMR characterization of diastereomeric CPSMeG derivatives.
Synthesis and stereochemical characterization of enantiomerically pure CPSMeG derivatives by NMR methods are reported. The effect of 5'-dimethoxytrityl on the conformational properties is described. It was found that in P-diastereomers the conformational differences about the C3'-O3' bond, as discernible from the delta J values, are enhanced by the presence of this protecting group.
Machytka
D
D
Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary.
Sági
G
G
Kajtár-Peredy
M
M
Gács-Baitz
E
E
D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D003596:Cytosine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D015226:Dinucleoside Phosphates / Q000138:chemical synthesis*; D006147:Guanine / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D063065:Organophosphonates / Q000737:chemistry; D013237:Stereoisomerism
D015226:Dinucleoside Phosphates; D063065:Organophosphonates; D006147:Guanine; D003596:Cytosine