Cytotoxic neolignans from the stem wood of Machilus obovatifolia.
Four new cytotoxic neolignans, machilusol A (1), machilusol C (3), machilusol D (4), machilusol E (5) as well as two new inactive neolignans, machilusol B (2) and machilusol F (6), were isolated from the stem wood of Machilus obovatifolia. All structures were identified by means of spectroscopic analysis.
Tsai
I L
IL
Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan, R.O.C. ialits@cc.kmu.edu.tw
Chen
J H
JH
Duh
C Y
CY
Chen
I S
IS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones; D003124:Colorimetry; D019073:HT29 Cells; D006801:Humans; D007097:Imines; D007202:Indicators and Reagents; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D014197:Trees / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D014934:Wood
D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D007097:Imines; D007202:Indicators and Reagents; D017705:Lignans; D010936:Plant Extracts; C010358:N,2,6-trichloro-4-benzoquinone imine