title: Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease.
authors.affiliation: Amgen, One Amgen Center Drive, Thousand Oaks, California 91320-1789, USA. grishton@amgen.com
authors.forename: G M
authors.initials: GM
authors.lastname: Rishton
authors.forename: D M
authors.initials: DM
authors.lastname: Retz
authors.forename: P A
authors.initials: PA
authors.lastname: Tempest
authors.forename: J
authors.initials: J
authors.lastname: Novotny
authors.forename: S
authors.initials: S
authors.lastname: Kahn
authors.forename: J J
authors.initials: JJ
authors.lastname: Treanor
authors.forename: J D
authors.initials: JD
authors.lastname: Lile
authors.forename: M
authors.initials: M
authors.lastname: Citron
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D016282:Aspartic Acid Endopeptidases; D002460:Cell Line; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D009636:Norbornanes / Q000138:chemical synthesis* / Q000737:chemistry; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D016229:Amyloid beta-Peptides; D009636:Norbornanes; D011480:Protease Inhibitors; D013449:Sulfonamides; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human