Relationship between obsessive-compulsive disorders and diseases affecting primarily the basal ganglia.
Obsessive-compulsive disorder (OCD) has been reported in association with some neurological diseases that affect the basal ganglia such as Tourette's syndrome, Sydenham's chorea, Parkinson's disease, and Huntington's disease. Furthermore, studies such as neuroimaging, suggest a role of the basal ganglia in the pathophysiology of OCD. The aim of this paper is to describe the association of OCD and several neurologic disorders affecting the basal ganglia, report the existing evidences of the role of the basal ganglia in the pathophysiology of OCD, and analyze the mechanisms probably involved in this pathophysiology.
Maia
A S
AS
Departments of Psychiatrics and Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil.
Barbosa
E R
ER
Menezes
P R
PR
Miguel Filho
E C
EC
D001479:Basal Ganglia / Q000503:physiopathology; D001480:Basal Ganglia Diseases / Q000150:complications*; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000503:physiopathology