title: Effects of fluconazole and clarithromycin on rifabutin and 25-O-desacetylrifabutin pharmacokinetics.
abstract: Ten human immunodeficiency virus-infected patients were given rifabutin in addition to fluconazole and clarithromycin. There was a 76% increase in the area under the concentration-time curve of rifabutin when either fluconazole or clarithromycin was given alone and a 152% increase when both drugs were given together with rifabutin. Patients should be monitored for adverse effects of rifabutin administered concomitantly with clarithromycin and/or fluconazole.
authors.affiliation: Department of Pharmacy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Jordan
authors.forename: M A
authors.initials: MA
authors.lastname: Polis
authors.forename: G
authors.initials: G
authors.lastname: Kelly
authors.forename: P K
authors.initials: PK
authors.lastname: Narang
authors.forename: H
authors.initials: H
authors.lastname: Masur
authors.forename: S C
authors.initials: SC
authors.lastname: Piscitelli
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000904:Antibiotics, Antitubercular / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D000935:Antifungal Agents / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000494:pharmacology*; D015658:HIV Infections / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017828:Rifabutin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D000935:Antifungal Agents; C107196:25-desacetylrifabutin; D017828:Rifabutin; D015725:Fluconazole; D017291:Clarithromycin