title: Synthesis and biological activity of conformationally controlled 2-PAM derivatives.
abstract: A series of conformationally controlled 2-PAM derivatives were prepared from 2-acetylpyridine and 2,3-pyrido[b]cycloalkenones in two steps and their reactivities towards parathion poisoned AChE were evaluated. The most planar 2,3-pyrido[b]cyclohexanone oxime methiodide showed an activity comparable to 2-PAM implying E-syn is that the most active conformation of 2-PAM in the biological system.
authors.affiliation: College of Pharmacy, Yeungnam University, Kyongsan, Korea. ydjahng@ynucc.yeungnam.ac.kr
authors.forename: Y
authors.initials: Y
authors.lastname: Jahng
authors.forename: J G
authors.initials: JG
authors.lastname: Park
authors.forename: J W
authors.initials: JW
authors.lastname: Yoo
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Yang
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D001665:Binding Sites; D002801:Cholinesterase Reactivators / Q000737:chemistry*; D011220:Pralidoxime Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D002801:Cholinesterase Reactivators; D011220:Pralidoxime Compounds; D000110:Acetylcholinesterase; C028797:pralidoxime