Cancer chemopreventive activity of an iridoid glycoside, 8-acetylharpagide, from Ajuga decumbens.
In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Labiatae plants were screened. Consequently, the iridoid glycoside derivative, 8-acetylharpagide (8-AcHarp), was obtained from the flowering whole plant of Ajuga decumbens as an active constituent. This glycoside exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors induced by nitric oxide (NO) donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexen eamide (NOR 1) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, 8-AcHarp exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter.
Konoshima
T
T
Kyoto Pharmaceutical University, Yamashina-ku, Japan. konosima@mb.kyoto-phu.ac.jp
Takasaki
M
M
Tokuda
H
H
Nishino
H
H
D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000956:Antigens, Viral / Q000096:biosynthesis; D002273:Carcinogens; D004052:Diethylnitrosamine; D005260:Female; D005960:Glucosides / Q000302:isolation & purification / Q000627:therapeutic use; D039823:Iridoids; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D008813:Mice, Inbred ICR; D018632:Mice, Inbred SENCAR; D009574:Nitro Compounds; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D011714:Pyrans / Q000302:isolation & purification / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D002273:Carcinogens; C033305:Epstein-Barr virus early antigen; D005960:Glucosides; D039823:Iridoids; D009574:Nitro Compounds; D010936:Plant Extracts; D011714:Pyrans; C101316:methyl-2-hydroxyimino-5-nitro-6-methoxy-3-hexeneamide; D004052:Diethylnitrosamine; C077626:8-O-acetylharpagide