Identification of a novel HLA-B46 allele, B*4602, in Japanese.
The B*4602 was identified in a healthy Japanese donor. The B46 variant antigen differed serologically from B46. The nucleotide sequence of B*4602 differed from that of B*4601 by a single base (from A to G) at position 293 in exon 2. The substitution changed the amino acid Asp at position 74 to Gly. The gene frequency of B*4602 in the Japanese population is extremely low. The presumed haplotype of B*4602 was HLA-A2-Cw1-B*4602-DRB1*09. This is the first report of polymorphism of the B46 antigen.
Akesaka
T
T
Japanese Red Cross Central Blood Center, Hoshi University, Tokyo.
Kashiwase
K
K
Shimamura
M
M
Ishikawa
Y
Y
Tanaka
H
H
Fujii
M
M
Akaza
T
T
Hando
K
K
Yuasa
S
S
Takahashi
T
T
Juji
T
T
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D005091:Exons; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D014019:Tissue Donors
D015235:HLA-B Antigens; C080311:HLA-B46 antigen