title: Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method.
abstract: Solid-phase synthetic method of muramyl dipeptide derivatives is reported. A diverse library of muramyl dipeptides could be potentially synthesized by acylation, reductive alkylation, sulfonamide formation, urea formation, N-alkylation, amine addition, or component Ugi reactions based on this method for drug screening.
authors.affiliation: Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing, China. gangliu27@yahoo.com
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: S D
authors.initials: SD
authors.lastname: Zhang
authors.forename: S Q
authors.initials: SQ
authors.lastname: Xia
authors.forename: Z K
authors.initials: ZK
authors.lastname: Ding
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000138:chemical synthesis / Q000737:chemistry*; D000215:Acylation; D000478:Alkylation; D013449:Sulfonamides / Q000737:chemistry; D014508:Urea / Q000737:chemistry
chemical_list: D013449:Sulfonamides; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D014508:Urea