title: Intestinal absorption of calcium from foodstuffs as compared to a pharmaceutical preparation.
abstract: Only few data are available on intestinal calcium absorption from foodstuffs and composite meals in humans. The aim of the study was to compare intraindividually the calcium absorption from milk and from a breakfast with that from a pharmaceutical calcium preparation of equal calcium content. In 8 healthy volunteers between 44 and 58 years of age, the intestinal calcium absorption was measured in randomized order applying the double isotope technique from: (1) 500ml of fresh milk (equivalent to 620mg Ca), (2) a test meal composed of 250 g curd, 150g yoghurt, 3 slices pineapple, 2 breakfast rolls, 2 cups of coffee, 10g of coffee cream, 20g butter, 50g jam and 20g honey (equivalent to 580mg Ca), and (3) a lactogluconate effervescent tablet (equivalent to 500mgCa). All test doses were given on an empty stomach and labelled with 20mg 44Ca. Simultaneously, 5mg 42Ca in a sterile isotonic solution were injected intravenously. The mean values of the absorbed fractions are 24.0% +/- 5.4% (mean +/-SD), 17.9% +/- 7.1%, and 28.7% +/- 9.1% for the milk, for the meal and for the tablet respectively. The data show that less calcium is absorbed from foodstuffs as compared to a preparation of optimal bioavailability. But in this study only the difference between absorption from the milk and from the meal was statistically significant. Therefore, it is possible to obtain a sufficient calcium supply of the human body also by properly selected foodstuffs.
authors.affiliation: Institute of Radiation Protection, GSF-National Research Center for Environment and Health, Neuherberg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Werner
authors.forename: Ch
authors.initials: Ch
authors.lastname: Hansen
authors.forename: P
authors.initials: P
authors.lastname: Roth
authors.forename: J P
authors.initials: JP
authors.lastname: Kaltwasser
mesh_terms: D000328:Adult; D001682:Biological Availability; D002118:Calcium / Q000378:metabolism* / Q000493:pharmacokinetics; D005502:Food; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations; D002118:Calcium