title: DNA-cleavage studies on N-substituted monocyclic enediynes: enhancement of potency by incorporation of intercalating or electron poor aromatic ring and subsequent design of a novel phototriggerable acyclic enediyne.
abstract: A number of novel N-substituted enediynes (azaenediynes) 1-4 were synthesized as DNA cleaving agents. Enhancement of DNA cleavage potency was observed with those compounds which could interact with DNA through intercalation of the extended aromatic ring or through electrostatic attraction with electron poor aromatic ring. An acyclic enediyne 5 with a novel phototriggerable device was also synthesized and its DNA-cleaving activity was established.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Kharagpur. absk@hijli.iitkgp.ernet.in
authors.forename: A
authors.initials: A
authors.lastname: Basak
authors.forename: H M
authors.initials: HM
authors.lastname: Bdour
authors.forename: J C
authors.initials: JC
authors.lastname: Shain
authors.forename: S
authors.initials: S
authors.lastname: Mandal
authors.forename: K R
authors.initials: KR
authors.lastname: Rudra
authors.forename: S
authors.initials: S
authors.lastname: Nag
mesh_terms: D004247:DNA / Q000737:chemistry*; D004583:Electrons; D006868:Hydrolysis; D007364:Intercalating Agents / Q000737:chemistry*; D013058:Mass Spectrometry; D010777:Photochemistry
chemical_list: D007364:Intercalating Agents; D004247:DNA