title: CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.
abstract: The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+ subset of DC and that this pathway is important in establishing interferon gamma-dependent resistance to the protozoan parasite Toxoplasma gondii. These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function.
authors.affiliation: Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. jaliberti@niaid.nih.gov
authors.forename: J
authors.initials: J
authors.lastname: Aliberti
authors.forename: C
authors.initials: C
authors.lastname: Reis e Sousa
authors.forename: M
authors.initials: M
authors.lastname: Schito
authors.forename: S
authors.initials: S
authors.lastname: Hieny
authors.forename: T
authors.initials: T
authors.lastname: Wells
authors.forename: G B
authors.initials: GB
authors.lastname: Huffnagle
authors.forename: A
authors.initials: A
authors.lastname: Sher
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D007111:Immunity, Cellular; D018664:Interleukin-12 / Q000276:immunology*; D051379:Mice; D019713:Receptors, CCR5 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D016827:CD8 Antigens; D019713:Receptors, CCR5; D018664:Interleukin-12