Advances in signalling by extracellular nucleotides. the role and transduction mechanisms of P2Y receptors.
Nucleotides are ubiquitous intercellular messengers whose actions are mediated by specific receptors. Since the first clonings in 1993, it is known that nucleotide receptors belong to two families: the ionotropic P2X receptors and the metabotropic P2Y receptors. Five human P2Y receptor subtypes have been cloned so far and a sixth one must still be isolated. In this review we will show that they differ by their preference for adenine versus uracil nucleotides and triphospho versus diphospho nucleotides, as well as by their transduction mechanisms and cell expression.
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Institute of Interdisciplinary Research, School of Medicine, Free University of Brussels, Brussels, Belgium.
Janssens
R
R
Suarez-Huerta
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N
Robaye
B
B
Boeynaems
J M
JM
D000262:Adenylyl Cyclases / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D018118:Chloride Channels / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005089:Exocytosis; D005110:Extracellular Space / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008024:Ligands; D009711:Nucleotides / Q000737:chemistry / Q000502:physiology*; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D011494:Protein Kinases / Q000502:physiology; D018048:Receptors, Purinergic P2 / Q000187:drug effects / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship; D010738:Type C Phospholipases / Q000378:metabolism
D018118:Chloride Channels; D002712:Chlorides; D007473:Ion Channels; D008024:Ligands; D009711:Nucleotides; D018048:Receptors, Purinergic P2; D011993:Recombinant Fusion Proteins; D011494:Protein Kinases; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases; D043265:Phosphatidylinositol Diacylglycerol-Lyase