title: A four-part regimen for clinical heart failure.
abstract: Combination therapy with a diuretic, digoxin, ACE inhibitor, and beta-blocker can help patients with heart failure caused by severe systolic dysfunction feel better and live longer. Especially with ACE inhibitors and beta-blockers, the key to success is starting at low doses and titrating carefully to proven target doses. The demanding complexity of the four-drug regimen is well worth the results.
authors.affiliation: University of Maryland School of Medicine, Baltimore, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Freudenberger
authors.forename: S S
authors.initials: SS
authors.lastname: Gottlieb
authors.forename: S W
authors.initials: SW
authors.lastname: Robinson
authors.forename: M L
authors.initials: ML
authors.lastname: Fisher
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000627:therapeutic use; D004077:Digoxin / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002316:Cardiotonic Agents; D004232:Diuretics; D004077:Digoxin