Stepwise specification of lymphocyte developmental lineages.
B and T lymphocytes differentiate from multipotent precursors through distinct specification and commitment steps. New findings on the unique role of Pax5 in B-lineage commitment, dichotomous action of Notch signaling in B versus T cell development, and the gene expression changes comprising T-lineage specification and commitment now illuminate this process.
Rothenberg
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EV
Division of Biology, California Institute of Technology, Pasadena 91125, USA. evroth@its.caltech.edu
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D051757:PAX5 Transcription Factor; D011506:Proteins / Q000378:metabolism; D051880:Receptors, Notch; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C081976:EBF1 protein, human; D008565:Membrane Proteins; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; D011506:Proteins; D051880:Receptors, Notch; D015534:Trans-Activators; D014157:Transcription Factors