Formation of aromatic rings through enamine annulation
Condensation of pyrrolidine enamine of ketones with 1, 4-diacetoxy-2-butanone provides a new, concise synthetic route to substituted benzenes, dihydroindenes, tetrahydronaphthalenes, and di- and octahydrophenanthrenes. The reaction produced modest yields with regiocontrol of the secondary amine substituent.
Wang
C
Department of Chemistry, University of Houston, Houston, Texas 77204-5641, USA.
Kohn
H