title: The prospects for antisense therapy.
abstract: The use of short spans of nucleic acid--DNA or RNA--to disrupt the expression of disease-related genetic code is an idea potentially applicable to a vast number of illnesses, including most neoplasms. On several fronts, including hematologic malignancies, the concept has reached clinical trials--where appreciation of the in vivo hurdles is leading to new approaches for delivery of this new magic bullet.
authors.affiliation: University of Pennsylvania School of Medicine, Philadelphia, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Gewirtz
mesh_terms: D016375:Antisense Elements (Genetics) / Q000235:genetics / Q000627:therapeutic use*; D018390:Gene Targeting; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000628:therapy; D008957:Models, Genetic
chemical_list: D016375:Antisense Elements (Genetics)