Healing of porcine donor sites covered with silver-coated dressings.
OBJECTIVE
To compare rates of healing of donor sites in pigs between those dressed with silver-coated dressings and those dressed with petrolatum-impregnated absorbent gauze.


METHODS
Open study with each animal acting as its own control.


METHODS
University research facility, Canada.


METHODS
6 young specific-pathogen-free domestic pigs.


METHODS
A total of 72 wounds about 1 cm x 2 cm x 0.4 mm were made in rows of eight on each pig with a dermatome. They were divided into three groups of 24, and dressed with petrolatum gauze, or silver-coated dressings moistened with sterile water either once only or daily for 10 days. All dressings were secured in place with an elastic bandage.


METHODS
Erythema, infection, epidermal migration, and healing.


RESULTS
Wounds dressed with moistened silver-coated dressings re-epithelialised significantly more quickly. This resulted in complete re-epithelialisation within 70% of the time taken by those wounds dressed with petrolatum gauze.


CONCLUSIONS
Silver-coated dressings provide a moist environment for the healing wound combined with an effective antimicrobial agent, and this significantly accelerates healing compared with wounds dressed with traditional petrolatum gauze dressings.
Olson
M E
ME
LESARC, University of Calgary, AB, Canada.
Wright
J B
JB
Lam
K
K
Burrell
R E
RE
D000818:Animals; D001458:Bandages; D004195:Disease Models, Animal; D010577:Petrolatum / Q000627:therapeutic use*; D018030:Silver Compounds / Q000627:therapeutic use*; D016038:Skin Transplantation; D013552:Swine; D014182:Transplantation, Autologous; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000628:therapy*
D018030:Silver Compounds; D010577:Petrolatum