Hepatocyte migration during liver development requires Prox1.
Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.
Sosa-Pineda
B
B
Department of Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Wigle
J T
JT
Oliver
G
G
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D008099:Liver / Q000166:cytology* / Q000196:embryology; D051379:Mice; D025521:Tumor Suppressor Proteins; D000098551:Prospero-Related Homeobox 1 Protein
D018398:Homeodomain Proteins; D025521:Tumor Suppressor Proteins; D000098551:Prospero-Related Homeobox 1 Protein