title: Aromatase inhibitors from Isodon excisus var. coreanus.
abstract: The diethyl ether extract of Isodon excisus var. coreanus exhibited significant inhibitory activity in aromatase assay. Bioactivity-guided fractionation of the extract led to the isolation of three active compounds: inflexin (ent-1alpha-hydroxy-3beta,6a-diacetoxykaur-16-en-11,15-dione ) (1), ursolic acid (2), and ursolic acid 3-O-acetate (3).
authors.affiliation: PCRPS and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, USA. Hyehjean@nmdhst.cc.nih.gov
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeong
authors.forename: L C
authors.initials: LC
authors.lastname: Chang
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
authors.forename: I H
authors.initials: IH
authors.lastname: Kim
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
mesh_terms: D016588:Anticarcinogenic Agents / Q000302:isolation & purification; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*; D010920:Placenta / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D010936:Plant Extracts