title: Effects of fiber composition and hindlimb unloading on the vasodilator properties of skeletal muscle arterioles.
abstract: It has been hypothesized that microgravity-induced orthostatic hypotension may result from an exaggerated vasodilatory responsiveness of arteries. The purpose of this study was to determine whether skeletal muscle arterioles exhibit enhanced vasodilation in rats after 2 wk of hindlimb unloading (HU). First-order arterioles isolated from soleus and white gastrocnemius muscles were tested in vitro for vasodilatory responses to isoproterenol (Iso), adenosine (Ado), and sodium nitroprusside (SNP). HU had no effect on responses induced by Iso but diminished maximal vasodilation to Ado and SNP in both muscles. In addition, vasodilatory responses in arterioles from control rats varied between muscle types. Maximal dilations induced by Iso (soleus: 42 +/- 6%; white gastrocnemius: 60 +/- 7%) and Ado (soleus: 51 +/- 8%; white gastrocnemius: 81 +/- 6%) were greater in arterioles from white gastrocnemius muscles. These data do not support the hypothesis that microgravity-induced orthostatic hypotension results from an enhanced vasodilatory responsiveness of skeletal muscle arterioles. Furthermore, the data support the concept that dilatory responsiveness of arterioles varies in muscle composed of different fiber types.
authors.affiliation: Department of Health and Kinesiology, Cardiovascular Research Institute, Texas A&M University, College Station, Texas 77843, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: McCurdy
authors.forename: P N
authors.initials: PN
authors.lastname: Colleran
authors.forename: J
authors.initials: J
authors.lastname: Muller-Delp
authors.forename: M D
authors.initials: MD
authors.lastname: Delp
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001160:Arterioles / Q000502:physiology; D001824:Body Constitution; D006614:Hindlimb / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000166:cytology; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014664:Vasodilation / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology; D016474:Weight-Bearing / Q000502:physiology; D014893:Weightlessness
chemical_list: D000318:Adrenergic beta-Agonists; D014665:Vasodilator Agents; D009599:Nitroprusside; D000241:Adenosine; D007545:Isoproterenol