Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in Trypanosoma equiperdum.
A series of S-nitrosothiols, structurally related to the NO*-donor S-nitroso-N-acetylpenicillamine, and of organic nitrate esters that contain amidine groups which specify a recognition via the trypanosomal purine transporter P2, were synthesized and tested for their ability to inhibit the uptake of [2-(3)H]adenosine on Trypanosoma equiperdum.
Soulère
L
L
Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique-ESA-CNRS 5068, Université de Toulouse III, France.
Hoffmann
P
P
Bringaud
F
F
Périé
J
J
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000378:metabolism; D033703:Nucleoside Transport Proteins; D011684:Purine Nucleosides / Q000378:metabolism*; D014345:Trypanosoma / Q000378:metabolism*
D002352:Carrier Proteins; D008565:Membrane Proteins; D020030:Nitric Oxide Donors; D033703:Nucleoside Transport Proteins; D011684:Purine Nucleosides