title: Epidermal growth factor receptor signal transactivation.
abstract: Cross-communication between heterologous signaling systems and the epidermal growth factor receptor (EGFR) has been shown to be critical for a variety of biological responses: EGFR transactivation when G-protein-coupled receptors (GPCRs) are stimulated represents the paradigm of an interreceptor network that is dependent on G-proteins, kinases, metalloproteases, and growth factor precursors. Investigating the mechanism of this process will help expand our knowledge of physiological regulatory mechanisms and diverse pathophysiological disorders.
authors.affiliation: Max-Planck-Institut für Biochemie, Martinsried, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Leserer
authors.forename: A
authors.initials: A
authors.lastname: Gschwind
authors.forename: A
authors.initials: A
authors.lastname: Ullrich
mesh_terms: D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D015533:Transcriptional Activation
chemical_list: D016207:Cytokines; D008024:Ligands; D011956:Receptors, Cell Surface; D004815:Epidermal Growth Factor