Genetics of alcohol withdrawal.
Alcohol withdrawal is a clinically and etiologically heterogeneous syndrome caused by a complex interaction of environmental (e.g., amount of ethanol) and genetic factors. Multiple genes are considered to be involved in various components of the syndrome, each of them contributing only modestly to withdrawal vulnerability. Association studies using candidate genes of the dopamine, serotonin, gabaergic and opioidergic systems are reviewed and methodological limitations are discussed.
Schmidt
L G
LG
Department of Psychiatry, Free University of Berlin, Eschenallee 3, 14050 Berlin, Germany.
Sander
T
T
D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D011446:Prospective Studies; D012701:Serotonin / Q000235:genetics; D013375:Substance Withdrawal Syndrome / Q000235:genetics*; D005680:gamma-Aminobutyric Acid / Q000235:genetics
D012701:Serotonin; D005680:gamma-Aminobutyric Acid