Methylmalonic acid induces excitotoxic neuronal damage in vitro.
Kölker
S
S
Department of Neuropediatrics and Metabolic Diseases, University Children's Hospital, Marburg, Germany. koelker@mailer.uni-marburg.de
Ahlemeyer
B
B
Krieglstein
J
J
Hoffmann
G F
GF
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione / Q000378:metabolism / Q000494:pharmacology; D000409:Alanine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D002642:Chick Embryo; D016291:Dizocilpine Maleate / Q000378:metabolism / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism / Q000494:pharmacology; D008764:Methylmalonic Acid / Q000633:toxicity*; D019331:NG-Nitroarginine Methyl Ester / Q000378:metabolism / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000378:metabolism / Q000494:pharmacology; D009498:Neurotoxins / Q000633:toxicity*; D010880:Piperidines / Q000378:metabolism / Q000494:pharmacology
D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D009498:Neurotoxins; D010880:Piperidines; C000211:2-amino-3-phosphonopropionic acid; D016291:Dizocilpine Maleate; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D008764:Methylmalonic Acid; D000409:Alanine; C010739:ifenprodil; D019331:NG-Nitroarginine Methyl Ester