Screening for Staphylococcus epidermidis markers discriminating between skin-flora strains and those responsible for infections of joint prostheses.
Fifty-four Staphylococcus epidermidis strains responsible for infections of joint prostheses and 23 strains isolated from skin flora were studied for markers of virulence, to discriminate invasive strains from normal flora. They were screened for binding to polystyrene and matrix proteins and for the presence of staphylococcal genes involved in adhesion. The ica operon involved in biofilm formation was the only marker discriminating between these 2 categories of strains.
Galdbart
J O
JO
Unité des Staphylocoques, Centre National de Référence des Staphylocoques, Institut Pasteur, Paris, and Service de Microbiologie, Hôpital Beaujon, A.P.-H.P., Clichy, France.
Allignet
J
J
Tung
H S
HS
Rydèn
C
C
El Solh
N
N
D001422:Bacterial Adhesion; D015415:Biomarkers / Q000032:analysis; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006801:Humans; D007595:Joint Prosthesis / Q000382:microbiology*; D011137:Polystyrenes / Q000494:pharmacology; D016459:Prosthesis-Related Infections / Q000382:microbiology*; D012867:Skin / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity
D015415:Biomarkers; D016326:Extracellular Matrix Proteins; D011137:Polystyrenes