title: Combinatorial synthesis of heterocycles: solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives.
abstract: A new solid-phase synthesis of various substituted 2-amino-4(1H)-quinazolinones from a resin bound amine component is described. The amine was readily converted to the corresponding polymer bound S-methylthiopseudourea. Condensation with different substituted isatoic anhydrides afforded 2-amino-4(1H)-quinazolinone derivatives. The method is amenable for combinatorial library generation.
authors.affiliation: Chemical Sciences Division, Wyeth-Ayerst Research, Pearl River, New York 10965, USA.
authors.forename: A
authors.initials: A
authors.lastname: Gopalsamy
authors.forename: H
authors.initials: H
authors.lastname: Yang
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D007202:Indicators and Reagents; D011799:Quinazolines