[Use of pentoxifylline in pediatric patients with grade IV (OMS) lupus nephropathy who have received multiple treatments].
OBJECTIVE
Systemic Lupus Eritematosus is an autoimmune disease, the incidence in pediatric poblation in about 5%, and until 90% develop nephropathy.


METHODS
Included patients with lupic nephropathy grade IV (OMS) ages between 0 and 16 years old, multitreated, who administrated PTX. We take samples before treatment, during, and 4 month after, evaluating renal function and hepatic function.


RESULTS
For female, tow male, promedium age 14.1 years old. Poteinuria get a significative p = 0.0012; hematuria was lowering its levels, While immune circulating complex, get too a significative p = 0.0050. In creatinine inverse showed an important modification of its pending.


CONCLUSIONS
This results demonstrates, that PTX in nephritis lupic patients, helps to brake the habitual deterioration in renal function. Includes more patients for a long time of treatment, we'll get better results than this.
Vázquez García
M J
MJ
Departamento de Alergia e Inmunología Clínica, Hospital General Dr. Darío Fernández F, México D.F. jambofly@yahoo.com
Vargas Camaño
M E
ME
Olalde Carmona
R
R
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000145:classification / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D009393:Nephritis / Q000188:drug therapy* / Q000209:etiology*; D010431:Pentoxifylline / Q000627:therapeutic use*
D010431:Pentoxifylline