title: Efficacy of unilateral deep brain stimulation of the thalamic ventralis intermedius nucleus in a patient with bipolar disorder associated with Klinefelter syndrome and essential tremor. Case report.
abstract: Deep brain stimulation (DBS) of the ventralis intermedius nucleus (Vim) is a safe and effective treatment for essential tremor. Bipolar disorder and essential tremor had each been reported to occur in association with Klinefelter syndrome but the three diseases have been reported to occur together in only one patient. The genetic basis and natural history of these disorders are not completely understood and may be related rather than coincidental. The authors report on a 23-year-old man with Klinefelter syndrome (47,XXY) and bipolar disorder who was treated successfully with unilateral DBS of the thalamic Vim for essential tremor.
authors.affiliation: Department of Neurosurgery, Pennsylvania Neurological Institute at Pennsylvania Hospital, Hospital of the University of Pennsylvania, Philadelphia 19104, USA. Telfeian@mail.med.upenn.edu
authors.forename: A E
authors.initials: AE
authors.lastname: Telfeian
authors.forename: J A
authors.initials: JA
authors.lastname: Boockvar
authors.forename: T
authors.initials: T
authors.lastname: Simuni
authors.forename: J
authors.initials: J
authors.lastname: Jaggi
authors.forename: B
authors.initials: B
authors.lastname: Skolnick
authors.forename: G H
authors.initials: GH
authors.lastname: Baltuch
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D004599:Electric Stimulation Therapy; D020329:Essential Tremor / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007713:Klinefelter Syndrome / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D016896:Treatment Outcome; D020651:Ventral Thalamic Nuclei / Q000503:physiopathology*