CD4(+) lymphocyte-mediated suppression of cytomegalovirus expression in human astrocytes.
Cytomegalovirus-stimulated CD4(+) lymphocytes from seropositive but not seronegative donors suppressed viral gene expression in primary human astrocytes. This suppressive activity was mediated through soluble factors. These findings suggest that CD4(+) lymphocytes play a role in defense of the brain against cytomegalovirus.
Cheeran
M C
MC
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, Minneapolis, Minnesota 55404, USA.
Gekker
G
G
Hu
S
S
Yager
S L
SL
Peterson
P K
PK
Lokensgard
J R
JR
D001253:Astrocytes / Q000276:immunology / Q000821:virology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D003587:Cytomegalovirus / Q000502:physiology*; D006801:Humans; D014779:Virus Replication / Q000276:immunology