The first, second, third and fourth order Markov chain analysis on the amino-acid sequence of human dopamine beta-hydroxylase.
The repeated amino-acid sequences in human dopamine beta-hydroxylase (DBH) may be indispensable for DBH activity, because such repetitions cannot be simply attributed to random chance. The amino acid sequence of human DBH was analysed according to two-, three-, four- and five-amino-acid sequences and their probabilities in human DBH were calculated. The first, second, third and fourth order Markov chain was used to calculate the transition probability for two-, three-, four- and five-amino-acid sequences. The longest repeated sequence is glycine-isoleucine-leucine-glutamic acid-glutamic acid, which appears twice in DBH. The results suggest that the amino acids with a high Markov transition probability may serve as the potential targets of new drugs, because they are unlikely to change into other amino acids.
Wu
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Biochemistry Section, Department of Basic Medicine, National Institute for Minamata Disease, Minamata, Kumamoto 867, Japan.
D000595:Amino Acid Sequence; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D006801:Humans; D008390:Markov Chains; D008957:Models, Genetic; D012559:Schizophrenia / Q000235:genetics
D004299:Dopamine beta-Hydroxylase