[Pharmacological reminder of the emotional condition facilitates the amnestic memory trace retrieval].
Passive avoidance reflex was shown to be differently reproduced in rats. The reproduction was more stable in rats with a higher level of learning. Amnestic effects induced seizures were shown to depend on relationships between the intensity of learning and the intensity of seizures. Unconditioned stimuli acting as a reminder decreased the amnestic effects of seizures. Learning process significantly reduced the seizure severity. A dissociated convulsive state was reproduced with the aid of a pharmacological reminder of anxiety formed in the course of learning. Haloperidol produced anxiety and suppressed amnestic effects of seizures, facilitated conditioning in rats with a low level of learning.
Bazian
A S
AS
Institute of Higher Nervous Activity and Neurophysiology, Russian Acad. Sci., Moscow, Russia.
Getsova
V M
VM
Orlova
N V
NV
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D003214:Conditioning, Classical / Q000502:physiology; D003292:Convulsants; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000523:psychology
D003292:Convulsants; D006220:Haloperidol; D010433:Pentylenetetrazole