The role of calbindin and 1,25dihydroxyvitamin D3 in the kidney.
The identification of a putative apical Ca++ channel in 1,25dihydroxyvitamin D3 responsive epithelia (proximal intestine and the distal nephron) as well as recent studies using calbindin-D28k knock-out mice indicating the first direct in-vivo evidence for a role for this calcium-binding protein in renal calcium absorption suggest mechanisms, which had remained incomplete, related to the control of renal calcium absorption.
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA.
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K
Sooy
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Kohut
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S
Christakos
D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D002117:Calcitriol / Q000494:pharmacology / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D064030:S100 Calcium Binding Protein G / Q000235:genetics / Q000502:physiology*; D019459:Urothelium / Q000502:physiology*
C576498:CALB1 protein, human; C576499:Calb1 protein, mouse; D064092:Calbindin 1; D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D002117:Calcitriol; D002118:Calcium