Risk factors for neurological complications after acoustic neurinoma radiosurgery: refinement from further experiences.
OBJECTIVE
Further actuarial analyses of neurological complications were performed on a larger population treated by stereotactic radiosurgery at our institution, to establish the optimal treatment parameters.


METHODS
Between June 1990 and September 1998, 138 patients with acoustic neurinomas underwent stereotactic radiosurgery at Tokyo University Hospital. Of these, 125 patients who received medical follow-up for 6 months or more entered the present study. Patient ages ranged from 13 to 77 years (median, 53 years). Average tumor diameter ranged from 6.7 to 25.4 mm (mean, 13. 9 mm). Maximum tumor doses ranged from 20 to 40 Gy (mean, 29.8 Gy) and peripheral doses from 12 to 25 Gy (mean, 15.4 Gy). One to 12 isocenters were used (median, 4). Follow-up period ranged from 6 to 104 months (median, 37 months). The potential risk factors for neurological complications were analyzed by two univariate and one multivariate actuarial analyses. Neurological complications examined include hearing loss, facial palsy, and trigeminal nerve dysfunction. Variables included in the analyses were four demographic variables, two variables concerning tumor dimensions, and four variables concerning treatment parameters. A variable with significant p values (p < 0.05) on all three actuarial analyses was considered a risk factor.


RESULTS
The variables that had significant correlation to increasing the risk for each neurological complication were: Neurofibromatosis Type 2 (NF2) for both total hearing loss and pure tone threshold (PTA) elevation; history of prior surgical resection, tumor size, and the peripheral tumor dose for facial palsy; and the peripheral tumor dose and gender (being female) for trigeminal neuropathy. In facial palsies caused by radiosurgery, discrepancy between the course of palsy and electrophysiological responses was noted.


CONCLUSIONS
Risk factors for neurological complications seem to have been almost established, without large differences between institutions treating a large number of patients by radiosurgery. Radiosurgical doses and tumor dimensions were considered the two important risk factors for the 7th and 5th nerve injuries. Neurofibromatosis Type 2 was an important factor for hearing loss.
Department of Otolaryngology, Faculty of Medicine, University of Tokyo,Tokyo, Japan. itoken-tky@umin.ac.jp
K
K
Ito
M
M
Shin
M
M
Matsuzaki
K
K
Sugasawa
T
T
Sasaki
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003638:Deafness / Q000209:etiology*; D005158:Facial Paralysis / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D016518:Neurofibromatosis 2 / Q000150:complications; D009464:Neuroma, Acoustic / Q000601:surgery*; D016016:Proportional Hazards Models; D016634:Radiosurgery / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012307:Risk Factors; D020433:Trigeminal Nerve Diseases / Q000209:etiology*