[Alcohol consumption and anti-alcohol effect of afobazol in MR and NMRA rats].
Dynamics of the alcohol intake variation in MR and MNRA inbred rats with different emotional-stress reaction (ESR) phenotypes was studied in the course of a 7-month voluntary alcoholization. Initially, the MNRA rats with an active ESR phenotype showed a higher level of a 15% aqueous ethanol consumption than did the MR rats. After 3 months, the consumption of ethanol in the highly emotional MR rats sharply increased and was retained on a high level during subsequent alcoholization. The new anxiolytic agent afobazol [5-ethoxy-2(morpholinoethylthio)-benzimidazole hydrochliride] did not potentiate the CNS depressant action of alcohol. A 2-week administration of afobazol (1 mg/kg, i.p.) after a 6-month alcoholization markedly reduced the alcohol consumption and reduced the craving to alcohol in the rats of both lines studied.
Laboratory of Pharmacogenetics, Russian Academy of Medical Sciences, Moscow, Russia.
I V
IV
Viglinskaia
S B
SB
Seredenin
L G
LG
Kolik
D000428:Alcohol Drinking / Q000188:drug therapy* / Q000235:genetics; D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004357:Drug Synergism; D008297:Male; D009025:Morpholines / Q000627:therapeutic use*; D010641:Phenotype; D051381:Rats; D013045:Species Specificity; D013315:Stress, Psychological / Q000235:genetics
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines