[Fluocinonide Reference Standard (Control 981) of National Institute of Health Sciences].
The raw material of fluocinonide was examined for preparation of the "Fluocinonide Reference Standard (Control 981)". The analytical data obtained were: UV spectrum, lambda max of 237.4 nm; IR spectrum, same as that of the Fluocinonide Reference Standard (Control 841); optical rotation, [alpha]20(D) = + 84.4 degree, thin-layer chromatography, one impurity detected; high-performance liquid chromatography, three impurities detected and total amount estimated to be about 0.20%; loss on drying, 0.15%; assay by HPLC, 99.6% Based on the above results, the raw material was authorized as the Fluocinonide Reference Standard (Control 981) of the National Institute of Health Sciences.
Iwata
M
M
Maekawa
K
K
Saito
H
H
Tanimoto
T
T
Okada
S
S
D005447:Fluocinonide / Q000592:standards*; D006077:Government Agencies; D007564:Japan; D010602:Pharmacopoeias as Topic / Q000592:standards; D012015:Reference Standards
D005447:Fluocinonide