A pilot study of large volume apheresis of red blood cells and plasma during one donation by allogeneic blood donors.
As a pilot study, we assessed large volume apheresis of red blood cells (RBC) and plasma. The protocol was as follows: (a) 3-RBC group: 3 units (240 ml) of RBC were drawn, (b) RBC+P group: 2 units (160 ml) of RBC and 400 ml of plasma were drawn during one apheresis procedure, and (c)


METHODS
400 ml of whole blood was drawn by a manual method. Each group contained 7 healthy male donors of body weight 54-65 kg. We were able to perform these apheresis procedures without serious complications. Recovery of RBC for the donors of the 3-RBC group was delayed, but the level returned to the pre-donation level within nine weeks. The decreased total protein and albumin in the RBC+P group recovered within one week. The apheresed RBCs demonstrated the same quality as the manually collected RBC. These findings suggest that this apheresis approach may be applicable for routine donation.
Blood Transfusion Service, School of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyoku, 113-8519, Tokyo, Japan.
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F
Komatsu
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M
Kajiwara
D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D001782:Blood Donors; D017707:Erythrocyte Transfusion; D006801:Humans; D008297:Male; D010865:Pilot Projects; D010951:Plasma Exchange; D010956:Plasmapheresis / Q000379:methods; D014184:Transplantation, Homologous