Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor.
We describe a healthy peripheral blood stem cell (PBSC) donor who developed a cutaneous reaction, erythema exsudativum multiforme, during the administration of granulocyte colony-stimulating factor (G-CSF) for mobilization. The cutaneous lesions were located on his hips, apart from the site of G-CSF injection. Treatment with topical corticosteroid was commenced, and the lesions resolved completely within a week. Adverse cutaneous reactions induced by G-CSF have been reported infrequently in healthy donors. Further documentation of cases and their full evaluation will be of great importance for both physicians and PBSC donor.
Mori
T
T
Keio Bone Marrow Transplant Program, Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Sato
N
N
Watanabe
R
R
Okamoto
S
S
Ikeda
Y
Y
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D001782:Blood Donors; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000188:drug therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006615:Hip / Q000473:pathology; D006801:Humans; D007564:Japan; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000188:drug therapy; D014184:Transplantation, Homologous / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D016179:Granulocyte Colony-Stimulating Factor