Combining a beta2-agonist with a face mask to prevent exercise-induced bronchoconstriction.
BACKGROUND
In this study, we aimed to test the effect of combining a P2-agonist with a heat- and moisture-exchanging cellulose face mask in patients with bronchoconstriction induced by exercise in cold air.


METHODS
Nine allergic, asthmatic patients with a history of adverse reaction to exercise were tested on an ergometric bicycle at a temperature of approximately -10 degrees C. They were in turn given no treatment, given premedication with a beta2-agonist, allowed to breathe through a heat- and moisture-exchanging cellulose face mask, and given both premedication and the face mask. After each treatment regimen, they were subjected to provocation with exercise and cold air.


RESULTS
The decrease in FEV, was greatest with no therapy (mean maximal change: 27%), and this diminished when the face mask was used (mean maximal change: 12%,) or premedication with a 32-agonist was given (mean maximal change: 7%); no decrease in FEV1 occurred with the combination of agonist and face mask.


CONCLUSIONS
The results suggest that different mechanisms are involved in the pathophysiology of exercise-induced bronchoconstriction (EIB). This finding may be of importance for asthmatic athletes who train and compete in a cold climate and are affected by small changes in their lung function.
Allergy Centre, Sahlgrenska University Hospital, Gothenburg, Sweden.
E
E
Millqvist
U
U
Bengtsson
O
O
Löwhagen
D058666:Adrenergic beta-2 Receptor Agonists; D000328:Adult; D001250:Asthma, Exercise-Induced / Q000188:drug therapy* / Q000517:prevention & control*; D002482:Cellulose; D003080:Cold Temperature; D003131:Combined Modality Therapy; D004983:Ethanolamines / Q000627:therapeutic use; D005260:Female; D005541:Forced Expiratory Volume; D000068759:Formoterol Fumarate; D006358:Hot Temperature; D006801:Humans; D006813:Humidity; D008297:Male; D008397:Masks
D058666:Adrenergic beta-2 Receptor Agonists; D004983:Ethanolamines; D002482:Cellulose; D000068759:Formoterol Fumarate