[Clinical features and current progress of familial adenomatous polyposis].
Familial adenomatous polyposis(FAP) is inherited disease as an autosomal dominant trait in which the large intestine is diffusely carpeted by numerous adenomas with a high incidence of colorectal cancer. Current clinical aspects and biological progress were discussed with emphasis on diagnostic imaging, natural histories of gastrointestinal polyps and intra-mandibular osteomas. Genotype-phenotype correlation including attenuated type and function of APC gene, identified in 1991 as a responsible tumour suppressor one for FAP and Gardner syndrome, were also reviewed.
Ushio
K
K
Department of Radiology, National Kyushu Cancer Center.
D011125:Adenomatous Polyposis Coli / Q000235:genetics / Q000473:pathology; D005736:Gardner Syndrome; D005770:Gastrointestinal Neoplasms / Q000209:etiology / Q000473:pathology; D017491:Genes, APC; D005817:Genetic Counseling; D005838:Genotype; D006801:Humans; D010641:Phenotype