[Detection of type 6 human herpesvirus (HHV-6) specific DNA sequence in lymphoma tissues by PCR].
OBJECTIVE
To study the relationship between human herpesvirus-6 (HHV-6) and lymphoma in China.


METHODS
The specimens of paraffin-embedded lymphoma tissue, leukemia cell lines and normal blood donor peripheral blood lymphocytes(PBL) were examined for the presence of HHV-6 DNA sequence by polymerase chain reaction (PCR).


RESULTS
Of the 52 cases lymphoma studied, HHV-6 DNA sequence was detected in 21 cases; of 43 normal PBL, HHV-6 DNA sequence was detected in 8 cases. The difference was statistically significant (P < 0.05). HHV-6 DNA sequence was also present in two leukemia cell lines.


CONCLUSIONS
The results suggest that HHV-6 may be related to lymphoma in China.
Institute of Basic Medical Sciences, Academy of Medical Sciences, Peking Union Medical College, Beijing.
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D004279:DNA, Viral / Q000032:analysis*; D015654:Herpesvirus 6, Human / Q000235:genetics*; D006689:Hodgkin Disease / Q000821:virology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000821:virology; D014407:Tumor Cells, Cultured
D004279:DNA, Viral