Total percentage body weight changes during add-on therapy with tiagabine, carbamazepine and phenytoin.
Changes in body weight were evaluated in 349 patients from a study comparing efficacy of add-on therapy with tiagabine (TGB), carbamazepine (CBZ) or phenytoin (PHT). TGB add-on therapy showed no significant weight changes when added to either PHT or CBZ. CBZ add-on therapy showed a significant percentage weight gain of a mean body increase of 1.5% (P = 0.002). Adjunctive TGB therapy had no significant effect on total body weight, while adjunctive CBZ therapy was associated with weight gain.
Department of Neurology, Saint Louis University, MO 63110, USA.
R E
RE
Hogan
M E
ME
Bertrand
R L
RL
Deaton
K W
KW
Sommerville
D000927:Anticonvulsants / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects*; D002220:Carbamazepine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D009557:Nipecotic Acids / Q000627:therapeutic use*; D010672:Phenytoin / Q000627:therapeutic use*; D000078308:Tiagabine; D015430:Weight Gain
D000927:Anticonvulsants; D009557:Nipecotic Acids; D002220:Carbamazepine; D010672:Phenytoin; D000078308:Tiagabine