Amiodarone-induced bone marrow granulomas.
Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias. In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or severe thrombocytopenia (case 2). Multiple bone marrow granulomas were found in both patients, without evidence of any other cause. In both patients the granulomas disappeared after amiodarone withdrawal, suggesting a direct association.
Departments of Molecular Biology & Haematology, St. George's Hospital Medical School, London, UK.
N Y
NY
Boutros
S
S
Dilly
D H
DH
Bevan
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy; D001706:Biopsy; D001855:Bone Marrow Diseases / Q000139:chemically induced*; D005260:Female; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D008297:Male
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone