Transplant of cultured autologous pure melanocytes after laser-abrasion for the treatment of segmental vitiligo.
Segmental vitiligo is a special type of vitiligo with unilateral distribution of lesions and has a stable course. Clinically, many patients with segmental vitiligo have unsatisfactory responses to topical corticosteroid or UV phototherapy. We have developed a technique for the isolation of melanocytes from a small specimen of normally pigmented skin obtained via a suction blister. The melanocytes can be proliferated in culture and then replanted onto laser-abrased vitiliginous areas. We used this procedure to treat 25 patients with segmental vitiligo that were refractory to medical therapy. The repigmented portion of the total treated area amounted to 95-100% in 21 patients and 65 to 94% in 4 patients. The response rate to treatment was 100% in this study. No scarring or other side-effects developed. The results of this study demonstrate that this method is a valuable tool for the treatment of patients with segmental vitiligo.
Department of Dermatology, Show Chwan Memorial Hospital, Changhua City, Taiwan, R.O.C.
Y F
YF
Chen
J S
JS
Chang
P Y
PY
Yang
C M
CM
Hung
M H
MH
Huang
D N
DN
Hu
D000293:Adolescent; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D003131:Combined Modality Therapy; D004954:Esthetics; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008544:Melanocytes / Q000637:transplantation*; D008875:Middle Aged; D017060:Patient Satisfaction; D014182:Transplantation, Autologous; D014820:Vitiligo / Q000175:diagnosis / Q000601:surgery*