Synthesis and evaluation of aza HUN-7293.
The aza analogue of the cyclic heptadepsipeptide HUN-7293 (1), which is a potent naturally occurring inhibitor of inducible cell adhesion molecule expression, and its C2(3) (MLEU3 C2) epimer were prepared via solution-phase synthesis. Biological evaluations of these two compounds as inhibitors of cell adhesion molecules expression are detailed.
Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA. boger@scripps.edu
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Boger
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Chen
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Foster
D002448:Cell Adhesion / Q000187:drug effects; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*
C097977:HUN 7293; D010456:Peptides, Cyclic