Comparison of the effects of inhalational anaesthetic agents on sympathetic activity in rabbits.
The effects of inhalational anaesthetic agents on renal sympathetic nerve activity (RSNA) were compared in anaesthetized rabbits. Concentrations of 6% desflurane, 1.2% isoflurane, and 2.4% enflurane increased mean RSNA up to 32, 36 and 44% while higher concentrations, of 12, 2.4 and 3.2% depressed it by 42, 83 and 5%, respectively. For halothane RSNA was unchanged up to 0.8% and decreased by 36% at 1.6% concentration. Nitrous oxide increased RSNA up to 28% at 50% concentration. Maximum reductions in mean arterial pressure (MAP) were 60% for both 2.4% isoflurane and 3.2% enflurane, 50% for 12% desflurane and 1.6% halothane, while 70% nitrous oxide increased MAP by 22%. In conclusion, unlike the entirely depressive effects of halothane, the effects of desflurane, isoflurane and enflurane were biphasic involving excitation at lower concentrations and depression of RSNA and a reduction in MAP at higher concentrations. Nitrous oxide caused increases in both RSNA and MAP.
Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
C K
CK
Pac-Soo
C
C
Wang
M K
MK
Chakrabarti
J G
JG
Whitwam
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002319:Cardiovascular System / Q000294:innervation; D004305:Dose-Response Relationship, Drug; D004737:Enflurane / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007530:Isoflurane / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000294:innervation; D008297:Male; D009609:Nitrous Oxide / Q000494:pharmacology; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects*
D018685:Anesthetics, Inhalation; D004737:Enflurane; D007530:Isoflurane; D009609:Nitrous Oxide