Fetal erythropoietin levels in pregnancies complicated by meconium passage: does meconium suggest fetal hypoxia?
OBJECTIVE
We sought to determine whether umbilical cord plasma erythropoietin levels were different in deliveries complicated by meconium passage and to determine whether this response is influenced by gestational age.


METHODS
Fetal erythropoietin levels were measured in 203 appropriately grown neonates at 37 to 43 weeks of gestation; among those, 70 had passed meconium.


RESULTS
Meconium passage in the entire population was associated with elevated fetal erythropoietin levels (68 vs 31 mIU/mL; P <.001). Cord blood gases, pH, base deficit, and PO (2), as well as the 1- and 5-minute Apgar scores, were not different between the meconium and no-meconium groups. Gestational age and birth weights were significantly higher in the meconium group. Stepwise multiple regression analysis with meconium and gestational age used as the independent variables showed both meconium and gestational age to be independently associated with fetal erythropoietin levels (r = 0.356, F = 14.5; meconium, P <.001; gestational age, P <.01).


CONCLUSIONS
These results suggest that meconium passage can be associated with chronic fetal hypoxia as demonstrated by elevated fetal erythropoietin levels, independent of gestational age.
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, USA. obgaj@ttuhsc.edu
A
A
Jazayeri
L
L
Politz
J C
JC
Tsibris
T
T
Queen
W N
WN
Spellacy
D001034:Apgar Score; D001724:Birth Weight; D004921:Erythropoietin / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005311:Fetal Hypoxia / Q000175:diagnosis*; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D016015:Logistic Models; D008470:Meconium; D016017:Odds Ratio; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D012044:Regression Analysis
D004921:Erythropoietin; D010100:Oxygen