Type IV collagen as an early marker for diabetic nephropathy in non-insulin-dependent diabetes mellitus.
We measured urinary albumin (U-Alb) and type IV collagen (uIV.C) in spot urine collected from 82 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 205 controls. Eighty-two NIDDM patients that had no increased excretion of either U-Alb or uIV.C were observed for 6 months. Prevalence of increased excretion of U-Alb and uIV.C at 6 months in these patients were 32.9%, and 62.2%, respectively. Increased excretion of uIV.C was detected in 27 patients without microalbuminuria. chi(2) analysis suggested that uIV.C was more sensitive than U-Alb, and that hypertension enhanced increased excretion of both U-Alb and uIV.C. uIV.C was significantly correlated (P<0.01) with U-Alb but not glycosylated hemoglobin A1C (HbA1C) in NIDDM patients. Taken together, uIV.C may be a useful marker for early diabetic nephropathy.
Department of Laboratory Medicine and Clinical Laboratory Center, Gunma University School of Medicine, 371-8511, Maebashi, Japan.
N
N
Kotajima
T
T
Kimura
T
T
Kanda
K
K
Obata
A
A
Kuwabara
Y
Y
Fukumura
I
I
Kobayashi
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000652:urine; D015415:Biomarkers / Q000652:urine*; D003094:Collagen / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000628:therapy / Q000652:urine*; D003928:Diabetic Nephropathies / Q000652:urine*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000652:urine; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D003094:Collagen; D006442:Glycated Hemoglobin