Pyloroplasty improves long-term gastric emptying in rats undergoing fundoplication.
BACKGROUND
Conflicting reports exist regarding the permanence of improved gastric emptying (GE) after fundoplication for gastroesophageal reflux in children.


METHODS
Changes in gastric volume (GV) and GE of a radiolabeled mixed meal induced by a Nissen fundoplication (NF) were compared with those with a NF plus pyloroplasty (NF + P). GE was measured preoperatively, 15 and 30 days postoperation, in 24 Sprague-Dawley rats; 12 had NF alone, and 12 had NF + P Results were expressed as percent gastric retention at 90 minutes (GR90). GV was measured at the same time periods in 20 additional rats.


RESULTS
NF rats had enhanced GE with reduction of preoperative GR90 from 37.6% to 23.7% at 15 days (P < .05); however, at 30 days the GR90 increased to 34.3%. NF + P rats had enhanced GE with reduction in GR90 from 37.2% to 20.8% at 15 days (P< .05), which persisted at 30 days (20.4%). Mean GV decreased from (1.36 mL/100 g body weight) preoperation to 0.86 at 15 days (P< .05) at 15 days in the NF group, and returned to 1.29 at 30 days. Mean GV decreased from 1.36 to 0.91 at 15 days in the NF + P rats and persisted at 0.90 at 30 days.


CONCLUSIONS
In the rat model, NF enhances GE transiently, whereas NF + P produces long-term enhancement of GE.
Department of Surgery, UCLA School of Medicine, Los Angeles, California 90095, USA.
J
J
Bustorff-Silva
E W
EW
Fonkalsrud
C A
CA
Perez
C
C
Hoh
H E
HE
Raybould
J B
JB
Atkinson
D000818:Animals; D018662:Fundoplication; D005746:Gastric Emptying; D008297:Male; D011708:Pylorus / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors