[Pharmacological study of papain from the papaya plant cultivated in Uzbekistan].
It was experimentally established that papain from papaya cultivated in Uzbekistan possesses a pronounced proteolytic activity: 0.1, 0.5, and 1% papain solutions decreased the weight of burn crust in vitro and accelerated experimental burn healing in vivo. Under clinical conditions, papain produced therapeutic effect in patients with inflammatory disorders in genitals, intestine, liver, and eye. The pharmacological effects of papain produced from Uzbek papaya are identical to those of the commercial product from Merck.
Second Tashkent State Medical Institute, Republic of Uzbekistan.
M R
MR
Rakhimov
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002056:Burns / Q000188:drug therapy; D005128:Eye Diseases / Q000188:drug therapy; D006168:Guinea Pigs; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007928:Lethal Dose 50; D051379:Mice; D010206:Papain / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013696:Temperature; D014945:Wound Healing / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D010206:Papain