Safety and efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) in children with elevated blood lead concentrations.
OBJECTIVE
To evaluate the safety and efficacy of meso-2,3-dimercaptosuccinic acid in the treatment of children with lead toxicity.


METHODS
This was an open-label study in 59 children 12-65-months old, with pretreatment whole-blood lead levels of 25-66 microg/dL, who received 116, 26-28 day courses of oral dimer-captosuccinic acid, while residing either in the Pediatric Clinical Research Unit of the Johns Hopkins Hospital or in lead-safe housing during the outpatient portion of the study.


RESULTS
All, who completed the study, showed sharp decreases in blood lead concentration during therapy, but 2-3 weeks following completion of drug therapy, blood lead concentration rebounded to an average of 58% (23 microg Pb/dL of whole blood) of their average pretreatment blood lead concentration (40 microg Pb/dL of whole blood). There were no adverse reactions attributable to dimercaptosuccinic acid; however, 2 of the 59 patients were reexposed to defective lead paint and experienced sharp increases in blood lead concentration while on therapy. In one instance, the child's blood lead concentration increased from 20 to 90 microg Pb/dL whole blood in 1 week. Other unexpected events were discussed in the text.


CONCLUSIONS
Dimercaptosuccinic acid is apparently safe and does mobilize lead into the urine, but not the essential metals, zinc and copper. Reexposure is always a danger; therefore, all children, while on therapy, should be monitored for their blood lead concentration at weekly intervals during and immediately after therapy. No conclusions can be drawn from this study regarding long-term beneficial effects, if any, of this drug on late neurocognitive outcome.
Lead Poisoning Program, The Kennedy Krieger Institute, Baltimore, Maryland 21205, USA.
J J
JJ
Chisolm
D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000097:blood; D000755:Anemia, Sickle Cell / Q000150:complications; D000931:Antidotes / Q000008:administration & dosage* / Q000009:adverse effects; D002614:Chelating Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003300:Copper / Q000652:urine; D003404:Creatinine / Q000652:urine; D003710:Demography; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications; D006801:Humans; D007223:Infant; D007854:Lead / Q000097:blood* / Q000652:urine; D007855:Lead Poisoning / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D004113:Succimer / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D015032:Zinc / Q000652:urine
D000931:Antidotes; D002614:Chelating Agents; D007854:Lead; D003300:Copper; D003404:Creatinine; D004113:Succimer; D000469:Alkaline Phosphatase; D015032:Zinc