[Topical treatment of peri-implantitis with metronidazole dental gel 25%. Clinical analysis and microbiological control].
BACKGROUND
Aim of this research is to verify the efficacy of metronidazole dental gel 25%, used as a topical antibiotic for the treatment of peri-implantitis. The efficacy of the medicine in the starting phase of the disease (mucositis), as well as during peri-implantitis involving bone-bearing loss has been evaluated.


METHODS
Twenty patients were chosen as a sample for the study. After careful evaluation of the several protocols concerning peri-implantitis treatment, some diagnostic clinical parameters have been recorded for each patient and metronidazole dental gel 25% (Elyzol Cabon) has been administered in two applications at perimplants pocket (one after a week). For each patient 3 microbiological drawings were made for the evaluation of the bacterial population around the implant site.


RESULTS
From the microbiological examination a decrease of Gram- and an increase of Gram+ which returned in almost all the patients to normal levels have been observed; moreover, in all the patients a gradual decrease of PMN, resolution index of the inflammatory process was obtained, confirmed also by a remarkable improvement of all the observed diagnostic parameters, except for the peri-implants bone radiotransparency which was unchanged.


CONCLUSIONS
The research showed that the peri-implant diseases can be positively resolved by using the metronidazole dental gel 25% topical antibiotic. This drug led to a 60-70% decrease of Gram-, and 40-50% increase for Gram+, bringing these back to normal values in almost all the patients. Moreover, a good recovery of the peri-implants soft tissues has been observed.
Facoltà di Medicina e Chirurgia, Università degli Studi, Padova.
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E
Stellini
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Migliorato
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Mazzoleni
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A
Mottola
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Lombardi
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GA
Favero
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000302:isolation & purification; D015921:Dental Implants / Q000009:adverse effects*; D005069:Evaluation Studies as Topic; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology; D010518:Periodontitis / Q000209:etiology* / Q000517:prevention & control; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D015921:Dental Implants; D005782:Gels; D008795:Metronidazole