1,2-Dimethylhydrazine carcinogenesis in CBA male mice prenatally treated with diethylstilbestrol.
CBA female mice, at the 17th day of pregnancy, received single intraperitoneal injection of diethylstilbestrol (DES) at the dose of 1 mg/kg body weight (b. w.). Their descentands at the age of 2 months started receiving subcutaneous injections of 1,2-dimethylhydrazine (DMH) at the dose level of 8 mg(base)/kg b. w., total 15 weekly injections. Prenatal DES treatment of male mice considerably accelerated the development and increased the incidence of DMH-induced androgen-dependent renal adenomas and, notably, renal capsule angiosarcomas (RCA). In males receiving prenatal DES (without subsequent DMH-treatment), there was a statistically significant increase of renal adenomas and 9% of RCA were observed which are exceedinly rare in untreated mice. The enhancement of androgen-dependent tumourigenesis may be considered as an indication, even though indirect, of the hyperandrogenization produced in male mice by the prenatal DES treatment.
Institute of Carcinogenesis, N. N. Blokhin Cancer Research Centre, Moscow, Russian Federation.
V
V
Turusov
L
L
Trukhanova
D
D
Samoilov
D019813:1,2-Dimethylhydrazine / Q000008:administration & dosage*; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D003110:Colonic Neoplasms / Q000139:chemically induced; D004054:Diethylstilbestrol / Q000008:administration & dosage*; D005260:Female; D007274:Injections, Intraperitoneal; D007680:Kidney Neoplasms / Q000139:chemically induced; D051379:Mice; D008808:Mice, Inbred CBA; D009369:Neoplasms / Q000139:chemically induced*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012509:Sarcoma / Q000139:chemically induced
D004054:Diethylstilbestrol; D019813:1,2-Dimethylhydrazine