[Polymorphism of human alleles associated with genetic resistance against HIV-1 infection and its implications].
To investigate the genetic susceptibility of different ethnic populations to human immunodeficiency virus-1(HIV-1) infection by comparing the characteristics of gene mutation frequency and polymorphism of CCR5, CCR2 and SDF-1 alleles among different nationalities in the world. The recently reported data on AIDS progression in patients, and on gene mutation and polymorphism of CCR5, CCR2b and SDF-1 genes were collected. The data also included the HIV-1-associated genes polymorphisms of the Chinese individuals detected by the present authors. There was a significant link between the gene mutation, polymorphism of HIV-1-associated genes, genetic susceptibilities and the AIDS progression in patients, although the differences of HIV-1-associated gene mutation, polymorphisms existed among different ethnic populations in the world. The Chinese individuals are more likely to be infected by the M-tropic HIV-1 strain than the American Caucasian. The Chinese individuals have very low gene mutation of CCR5Delta32, which would be helpful for the prevention and gene therapy against the HIV-1 infection.
Wang
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F
Department of Bioengineering, Beijing Institute of Infectious Diseases, P. R. China. fushengw@public.bta.net.cn
Liu
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D
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000483:Alleles; D020022:Genetic Predisposition to Disease; D015497:HIV-1; D006801:Humans; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000235:genetics; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000235:genetics
C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine