[Target-controlled propofol infusion for general anesthesia in three obese patients].
We report three cases in which the target-controlled propofol infusion technique was used in obese patients for general anesthesia. General anesthesia was induced by intravenous administration of fentanyl 150-300 micrograms and ketamine 50-80 mg and propofol 2 micrograms.ml-1 to achieve a target blood concentration by target-controlled infusion system. Anesthetic maintenance was achieved by ketamine 1 mg.kg-1.h-1 for 1 hour after the induction, propofol at target blood concentration of 2-3.5 micrograms.ml-1 and the intermittent epidural injection of 1.5% lidocaine through an epidural catheter. The surgical procedures were uneventful. The estimated blood concentrations of propofol at emergence from anesthesia calculated by ConGrace ranged from 1.49-1.69 micrograms.ml-1, and it took 230-300 seconds to emerge from anesthesia. The target-controlled propofol infusion technique appears useful to control the depth of anesthesia in obese patients.
Kakinohana
M
M
Division of Anesthesia, Okinawa Prefectural Miyako Hospital, Hirara.
Tomiyama
H
H
Matsuda
S
S
Okuda
Y
Y
D000328:Adult; D000768:Anesthesia, General / Q000379:methods*; D000771:Anesthesia, Intravenous / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000097:blood; D002769:Cholelithiasis / Q000601:surgery; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D008875:Middle Aged; D009765:Obesity; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood
D018686:Anesthetics, Intravenous; D015742:Propofol