Radium-induced eye melanomas in dogs.
The intraocular radiotoxicity of intravenously injected 226Ra and 228Ra was studied in beagle dogs. Approximately 0.071% of injected radium was retained in each eye of beagles following intravenous administration. The retention was principally in the tapetum and the intraocular pigmented structures where significant pigmentary lesions were produced. These included melanotic plaques on the iris, melanosis of the ciliary body, varying degrees of tapetal degeneration, and intraocular melanomas. The tumors occurred principally in the ciliary body and to a much lesser extent in the iris. They appeared to arise from the pigment epithelium layer of the ciliary body. Thus, unlike melanomas arising in other sites, they are apparently not of neural crest origin. In addition to bone cancer, they represent another radium-induced neoplasm in beagles. Radium-induced intraocular melanomas have not been reported in people.
Taylor
G N
GN
Radiobiology Division 2334 CAMT, Salt Lake City, UT 84108-1218, USA. glen.taylor@hsc.utah.edu
Lloyd
R D
RD
Miller
S C
SC
Muggenburg
B A
BA
D000818:Animals; D002924:Ciliary Body / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005134:Eye Neoplasms / Q000209:etiology* / Q000473:pathology; D006965:Hyperplasia / Q000209:etiology; D007275:Injections, Intravenous; D007498:Iris / Q000473:pathology / Q000528:radiation effects; D016015:Logistic Models; D008546:Melanoma, Experimental / Q000209:etiology* / Q000473:pathology; D008548:Melanosis / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000528:radiation effects; D011883:Radium / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D012160:Retina / Q000378:metabolism / Q000473:pathology; D013995:Time
D011883:Radium