The many faces of mismatch repair in meiosis.
Mismatches, and the proteins that repair them, play multiple roles during meiosis from generating the diversity upon which selection acts to preventing the intermingling of diverged populations and species. The mechanisms by which the mismatch repair proteins accomplish these many roles include gene conversion, reciprocal crossing over, mismatch repair-induced recombination and anti-recombination. This review focuses on recent studies, predominantly in Saccharomyces cerevisiae, that have advanced our understanding of the details of mismatch repair complexes and how they apply to the diverse roles these proteins play in meiosis. These studies have also revealed unexpected and novel functions for some of the mismatch repair proteins.
Genome Stability Group, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK. rborts@molbiol.ox.ac.uk
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Abdullah
D020137:Base Pair Mismatch; D004260:DNA Repair / Q000502:physiology*; D005785:Gene Conversion; D005854:Germ Cells / Q000502:physiology; D006801:Humans; D008540:Meiosis; D009692:Nucleic Acid Heteroduplexes; D011995:Recombination, Genetic
D009692:Nucleic Acid Heteroduplexes