Renal tubular effects of endothelin-B receptor signaling: its role in cardiovascular homeostasis and extracellular volume regulation.
The role of the endothelin-B receptor in vascular homeostasis is controversial because the receptor has both pressor and depressor effects in vivo. One potential depressor mechanism of endothelin-B activation is through the promotion of natriuresis and diuresis in the renal tubule. Recent studies demonstrate that rodents genetically deficient for the endothelin-B exhibit sodium-dependent hypertension due to an absence of tonic inhibition of the epithelial sodium channel in the distal nephron. These studies suggest that the predominant role of endothelin-B receptors in the basal physiologic state may be to regulate renal sodium excretion relative to the level of oral salt intake.
Ohuchi
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Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, USA.
Yanagisawa
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M
Gariepy
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CE
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D005110:Extracellular Space / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology* / Q000503:physiopathology; D008954:Models, Biological; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin / Q000502:physiology*; D015398:Signal Transduction; D014882:Water-Electrolyte Balance
D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin