Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa.
In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Compositae plants were screened. Consequently, the lignans, arctiin (ARC) and arctigenin (ARC-G), were obtained from the aerial part of Saussurea medusaas active constituents. These compounds exhibited the remarkable anti-tumor-promoting effect on two-stage carcinogenesis test of mouse skin tumors induced by 7, 12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoyl phorbol-13-acetate as a promoter by both topical application and oral administration. Furthermore, ARC-G exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide as an initiator and glycerol as a promoter.
Takasaki
M
M
Kyoto Pharmaceutical University, Yamashina-ku, 607-8414, Kyoto, Japan.
Konoshima
T
T
Komatsu
K
K
Tokuda
H
H
Nishino
H
H
D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D019659:Asteraceae / Q000737:chemistry*; D002478:Cells, Cultured; D004195:Disease Models, Animal; D005260:Female; D005990:Glycerol; D017705:Lignans / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D018632:Mice, Inbred SENCAR; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D013755:Tetradecanoylphorbol Acetate
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate; D005990:Glycerol