Effect of mometasone furoate by topical application on allergic rhinitis model in rats.
The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate. Topical application of both drugs inhibited dose-dependently the increase of nasal symptoms (sneezing and nasal rubbing) after antigen challenge to the nasal cavity of actively sensitized rats. Mometasone furoate and fluticasone propionate at concentrations of 0.01 or 0.1% significantly inhibited both nasal rubbing and sneezing 1 h after topical application of both drugs. The relative potencies of mometasone furoate in nasal rubbing and sneezing compared to fluticasone propionate were 5.01 and 6.87, respectively. Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibited the increase of antigen-induced nasal rubbing even 6 h after topical application, indicating that both drugs have a long-lasting effect.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Y
Y
Sugimoto
K
K
Ishizawa
K
K
Saitou
G
G
Suzuki
T
T
Tarumi
H
H
Nakahara
Y
Y
Kirino
C
C
Kamei
D000287:Administration, Topical; D000730:Androstadienes / Q000627:therapeutic use; D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D000068298:Fluticasone; D008297:Male; D000068656:Mometasone Furoate; D017063:Outcome Assessment, Health Care; D011244:Pregnadienediols / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012220:Rhinitis / Q000188:drug therapy*
D000730:Androstadienes; D018926:Anti-Allergic Agents; D011244:Pregnadienediols; D000068656:Mometasone Furoate; D000068298:Fluticasone