Molecular biology. Transposase team puts a headlock on DNA.
Transposable DNA elements jump from one location in the genome to another. But, the cut-and-paste molecular machinations that support this nomadic lifestyle are still being unraveled. In their Perspective, Williams and Baker at the Massachusetts Institute of Technology discuss new details of transposon relocation revealed through resolution of the structure of a transposase enzyme bound to DNA (Davies et al.).
Williams
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Department of Chemistry, Office 68-517, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. tlwillia@mit.edu
Baker
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D020816:Amino Acid Motifs; D001665:Binding Sites; D002384:Catalysis; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004251:DNA Transposable Elements; D008024:Ligands; D008345:Manganese / Q000378:metabolism; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D019895:Transposases / Q000737:chemistry* / Q000378:metabolism*
D004251:DNA Transposable Elements; D008024:Ligands; D008345:Manganese; D004247:DNA; D019895:Transposases