Evidence of cross-protection within Leptospira interrogans in an experimental model.
Killed whole-cell preparations were used as bacterins against leptospirosis. As this type of protection is considered to be serogroup-specific, several serogroups were added to the usual vaccines, and the most pathogenic serovar was chosen for each group. Different leptospire extracts were evaluated for their protective capacity against acute lethal leptospirosis in gerbils (Meriones unguiculatus). Total extracts induced complete protection against homologous challenges and partial protection against heterologous challenges. LPS fractions protected against homologous but not heterologous challenges, whereas protein extract induced significant protection against both types of challenge. Thus, cross-protection within L. interrogans was related to the protein extract.
Ecole Nationale Vétérinaire de Nantes, Unité de Bactériologie Médicale et Moléculaire des Leptospires, Atlanpole, La Chantrerie, BP 40706, 44307, Nantes Cedex 03, France.
C
C
Sonrier
C
C
Branger
V
V
Michel
N
N
Ruvoën-Clouet
J P
JP
Ganière
G
G
André-Fontaine
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D001426:Bacterial Proteins / Q000008:administration & dosage; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D003429:Cross Reactions; D004195:Disease Models, Animal; D005260:Female; D005849:Gerbillinae; D007114:Immunization; D007921:Leptospira interrogans / Q000145:classification / Q000276:immunology*; D008297:Male; D014895:Weil Disease / Q000276:immunology / Q000517:prevention & control*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines