KL-6, a mucinous glycoprotein, as an indicator of chronic lung disease of the newborn.
KL-6 is a mucinous glycoprotein that is preferentially expressed by alveolar type 2 cells. Plasma KL-6 was higher in infants with chronic lung disease (n = 12) than in infants without chronic lung disease (n = 14) on day 0-1, 10, and 30 (P =.04). KL-6 correlated with the alveolar-arterial oxygen tension difference on day 10 and day 30. Plasma KL-6 may be useful as an early marker of chronic lung disease and an indicator of severity.
Department of Pediatrics, Division of Neonatology, Osaka Medical College, Osaka, Japan.
T
T
Ogihara
K
K
Hirano
T
T
Morinobu
S
S
Ogawa
M
M
Hiroi
R
R
Ban
H
H
Ogihara
H
H
Tamai
D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D015415:Biomarkers; D001997:Bronchopulmonary Dysplasia / Q000175:diagnosis*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D018396:Mucin-1; D009077:Mucins / Q000097:blood*; D010446:Peptide Fragments; D011347:Procollagen; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide