Hypergranular promyelocytic leukemia: correlation between morphology and chromosomal translocations including t(15;17) and t(11;17).
The FAB group has reviewed 32 cases of promyelocytic leukemia and variant forms. By utilizing published criteria the ability to make a correct diagnosis by morphology with molecular genetic confirmation and to eliminate cases that did not have the PML/RARalpha rearrangement was excellent.
University of Rochester Cancer Center, NY 14642, USA.
J M
JM
Bennett
D
D
Catovsky
M T
MT
Daniel
G
G
Flandrin
D A
DA
Galton
H R
HR
Gralnick
C L
CL
Willman
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002265:Carboxylic Ester Hydrolases / Q000032:analysis; D002880:Chromosomes, Human, Pair 11 / Q000648:ultrastructure*; D002884:Chromosomes, Human, Pair 15 / Q000648:ultrastructure*; D002886:Chromosomes, Human, Pair 17 / Q000648:ultrastructure*; D003594:Cytoplasmic Granules / Q000201:enzymology / Q000648:ultrastructure*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics; D014411:Neoplastic Stem Cells / Q000201:enzymology / Q000648:ultrastructure*; D015514:Oncogene Proteins, Fusion / Q000032:analysis / Q000235:genetics; D009195:Peroxidase / Q000032:analysis; D013194:Staining and Labeling; D014178:Translocation, Genetic; D014212:Tretinoin / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D014212:Tretinoin; D009195:Peroxidase; D002265:Carboxylic Ester Hydrolases; C019873:chloroacetate esterase