Relation between lipoprotein (a) and in vitro oxidation of apolipoprotein B-containing lipoproteins.
OBJECTIVE
To assess the relationship between lipoprotein (a) [Lp (a)] and lipoprotein oxidation in patients with coronary artery disease (CAD).


METHODS
Oxidation of apolipoprotein (apo)B-containing lipoproteins, vitamin E, carotenoids, lipid-lipoprotein levels were determined in 171 CAD and 70 non-CAD subjects.


RESULTS
In CAD patients with Lp (a) concentrations >/= 30 mg/dL; total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), and apo B levels were significantly higher and lag-time and age were significantly lower than those of CAD patients with Lp (a) concentrations < 30 mg/dL. In non-CAD subjects with Lp (a) concentrations >/= 30 mg/dL; TC, LDL-C, and vitamin E levels were significantly higher and lag-time was significantly lower than those of non-CAD subjects with Lp (a) concentrations < 30 mg/dL. In CAD patients, Lp (a) correlated negatively with lag-time and positively with MDA levels. Lp (a) correlated negatively with lag-time and vitamin E levels in non-CAD subjects.


CONCLUSIONS
We have shown that plasma apo B-containing lipoproteins of both CAD and non-CAD subjects with Lp (a) levels >/= 30 mg/dL are more susceptible to in vitro oxidative modification than those of subjects with Lp (a) levels < 30 mg/dL. The relationship between Lp (a) and enhanced susceptibility of apo B-containing lipoproteins to oxidation, appears to support routine investigation of Lp (a).
Department of Biochemistry, Medical Faculty of Uludağ University, Bursa, Turkey. akinserdar@superonline.com
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Tokullugil
D000328:Adult; D000368:Aged; D001055:Apolipoproteins B / Q000097:blood*; D002338:Carotenoids / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D014810:Vitamin E / Q000097:blood
D001055:Apolipoproteins B; D017270:Lipoprotein(a); D014810:Vitamin E; D002338:Carotenoids; D008315:Malondialdehyde