1,2-Dimethylhydrazine carcinogenesis in CBA male mice prenatally treated with diethylstilbestrol.
CBA female mice, at the 17th day of pregnancy, received single intraperitoneal injection of diethylstilbestrol (DES) at the dose of 1 mg/kg body weight (b. w.). Their descentands at the age of 2 months started receiving subcutaneous injections of 1,2-dimethylhydrazine (DMH) at the dose level of 8 mg(base)/kg b. w., total 15 weekly injections. Prenatal DES treatment of male mice considerably accelerated the development and increased the incidence of DMH-induced androgen-dependent renal adenomas and, notably, renal capsule angiosarcomas (RCA). In males receiving prenatal DES (without subsequent DMH-treatment), there was a statistically significant increase of renal adenomas and 9% of RCA were observed which are exceedinly rare in untreated mice. The enhancement of androgen-dependent tumourigenesis may be considered as an indication, even though indirect, of the hyperandrogenization produced in male mice by the prenatal DES treatment.
Turusov
V
V
Institute of Carcinogenesis, N. N. Blokhin Cancer Research Centre, Moscow, Russian Federation.
Trukhanova
L
L
Samoilov
D
D
D019813:1,2-Dimethylhydrazine / Q000008:administration & dosage*; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D003110:Colonic Neoplasms / Q000139:chemically induced; D004054:Diethylstilbestrol / Q000008:administration & dosage*; D005260:Female; D007274:Injections, Intraperitoneal; D007680:Kidney Neoplasms / Q000139:chemically induced; D051379:Mice; D008808:Mice, Inbred CBA; D009369:Neoplasms / Q000139:chemically induced*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012509:Sarcoma / Q000139:chemically induced
D004054:Diethylstilbestrol; D019813:1,2-Dimethylhydrazine