[The protective role of postvaccinal immunity in mumps in children].
The immunological study of children with infectious parotitis (IP) without complications and with such complications as pancreatitis, meningitis or orchitis in the glandular form was carried out. In accordance with the previously proposed principle, 4 types of immune response (IR) were established on the basis of differences in initial resistance and the IR profile: cell-mediated immunity (types I and III) and humoral immunity (types II and IV). The patients included nonvaccinated children, as well as children vaccinated on epidemic indications, 3-6, 7-9, 10 and more years before infection. The comparative analysis of the number of IP cases with and without complications in the groups of children, divided according to their immunization history and the type of IR, revealed that postvaccinal immunity in children vaccinated on epidemic indications (less than a month ago) or 3-6 years before infection had protective potential, sufficient for the prevention of complicated forms of IP. Immunity obtained 7-9 years ago was effective for the protection from IP complications only in cell-mediated, but not humoral IR. Postvaccinal immunity obtained more than 10 years ago did not ensure the decrease in the occurrence of complicated forms of IP (in comparison with that in nonvaccinated patients) in children with any type of IR.
Research Institute of Children's Infections, St. Petersburg, Russia.
G F
GF
Zheleznikova
V V
VV
Ivanova
M K
MK
Bekhtereva
Z U
ZU
Gnilevskaia
N E
NE
Monakhova
E V
EV
Novozhilova
O V
OV
Goleva
A N
AN
Sizemov
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D009107:Mumps / Q000150:complications / Q000276:immunology / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000276:immunology*; D009109:Mumps virus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D009108:Mumps Vaccine