Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology.
Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA.
W E
WE
Wright
J W
JW
Shay
D000818:Animals; D002455:Cell Division; D016922:Cellular Senescence; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000209:etiology* / Q000517:prevention & control*; D013045:Species Specificity; D019098:Telomerase / Q000235:genetics / Q000502:physiology; D016615:Telomere / Q000502:physiology*
D019098:Telomerase