Effect of Luffa echinata on lipid peroxidation and free radical scavenging activity.
The dried alcoholic (50%) extract of the plant Luffa echinata was investigated for inhibition of lipid peroxidation, for hydroxyl radical scavenging activity and interaction with 1,1-diphenyl-2-picrylhydrazyl stable free radical (DPPH). It was found that the test extract exhibited a considerable inhibition of lipid peroxidation and possessed hydroxyl radical scavenging activity. Evaluation of antiradical scavenging activity showed significant interaction with DPPH. These properties could be considered as a useful and exploitable combination for justifying the reported activity.
Department of Pharmacognosy, Government College of Pharmacy, Bangalore, Karnataka, India.
V P
VP
Kumar
S
S
Shashidhara
M M
MM
Kumar
B Y
BY
Sridhara
D000818:Animals; D015764:Bepridil / Q000031:analogs & derivatives* / Q000378:metabolism; D001713:Biphenyl Compounds; D019662:Cucurbitaceae / Q000737:chemistry*; D000431:Ethanol / Q000737:chemistry; D016166:Free Radical Scavengers / Q000378:metabolism*; D017665:Hydroxyl Radical / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010851:Picrates; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D017665:Hydroxyl Radical; D000431:Ethanol; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl