[Hypokalemic renal tubular syndromes: pathogenesis, diagnosis and therapy].
Hereditary tubular defects include syndromes with the retention of Na+, hypertension, hypokalemic metabolic alkalosis (Conn's and Liddle's syndromes) and syndromes with Na+ restriction, hypotension and hypokalemic metabolic alkalosis (Bartter's and Gitelman's syndromes). The understanding of their molecular mechanisms extended markedly with the improvement of their diagnostics, prevention and therapy. The paper reviews briefly their pathogenesis. (Tab. 4, Fig. 3, Ref. 38.)
Clinic of Pharmacotherapy, Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.
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Gazdikova
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Oksa
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Dzurik
D001477:Bartter Syndrome / Q000175:diagnosis; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis; D006973:Hypertension / Q000150:complications; D007008:Hypokalemia / Q000150:complications*; D007674:Kidney Diseases / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D013577:Syndrome