The dissolution kinetics of sulfamethoxazol, trimethoprim and oxytetracycline hydrochloride from multicomponent solid dispersion capsules ("Sulfoxytrim").
Release profiles and dissolution kinetics of active substance, viz. sulfamethoxazol (SMO), trimethoprim (TMP), and oxytetracycline hydrochloride (OTC) from capsulated multicomponent dispersions was studied in a flow-cell apparatus at 37 degrees C by using a dissolution medium of 0.1 mol/l HCl. The results revealed that the relative dissolution efficiency (DE) and dissolution profiles of one active ingredient were affected by the presence of the two others. Vitamin C added caused the decreased the dissolution rate constants (K) and DE--values of all the active substances studied.
Department of Applied Pharmacy, University of Medicine, Lublin, Poland.
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Zuń
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Czarnecki
D000900:Anti-Bacterial Agents / Q000032:analysis*; D000890:Anti-Infective Agents / Q000032:analysis*; D001205:Ascorbic Acid / Q000032:analysis; D002214:Capsules; D004359:Drug Therapy, Combination / Q000032:analysis*; D007202:Indicators and Reagents; D007700:Kinetics; D010118:Oxytetracycline / Q000032:analysis*; D012995:Solubility; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000032:analysis*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002214:Capsules; D007202:Indicators and Reagents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D001205:Ascorbic Acid; D010118:Oxytetracycline