Chemokines and viruses: the dearest enemies.
The relation between viruses and the chemokine system is characterized by a complex blend of enmity and attraction. Chemokines are key regulators of innate and adaptive immune responses against invading microorganisms, including viruses. They act not only as immune system "traffic officers," controlling leukocyte migration under both physiological and pathological conditions, but also as fine orchestrators that modulate the induction, amplification, and cytokine-secretion pattern of antiviral responses. However, viruses have succeeded in turning the chemokine system into an ally. During the course of a long parallel evolution, viruses have captured from their hosts the genetic information for encoding chemokines and chemokine receptors and have reprogrammed it for evading the control of the immune system. Moreover, selected viral agents, most notably primate immunodeficiency retroviruses, have adopted chemokine receptors as essential gateways for entry into their target cells. The endogenous secretion of chemokines is thus emerging as an important in vivo mechanism of viral control, which is potentially inducible by effective vaccines. The deepening knowledge of the interactions between viruses and chemokines may lead to novel therapeutic and preventive strategies for the control of viral and inflammatory diseases.
Lusso
P
P
Unit of Human Virology, DIBIT-San Raffaele Scientific Institute, Via Olgettina n. 58, Milan, 20132, Italy. paulo.lusso@hsr.it
D000818:Animals; D018925:Chemokines / Q000502:physiology*; D006801:Humans; D019707:Receptors, Chemokine / Q000502:physiology; D011991:Receptors, Virus / Q000502:physiology; D014777:Virus Diseases / Q000276:immunology; D014780:Viruses / Q000472:pathogenicity*
D018925:Chemokines; D019707:Receptors, Chemokine; D011991:Receptors, Virus