[A case of acute recurrent benign pericarditis in a patient with glucose-6-phosphate dehydrogenase deficiency, treated with sodium salicylate].
Glucose 6-phosphate dehydrogenase deficiency is an important cause of hemolysis. People with this disease are prone to hemolytic crisis induced by drugs, including acetylsalicylic acid. Sodium salicylate is the main therapeutic choice for acute idiopathic pericarditis. In vitro studies have demonstrated the role played by sodium salicylate in the inhibition of glucose 6-phosphate dehydrogenase, but, at therapeutic doses, this inhibition is not enough to explain acetylsalicylic acid-induced hemolysis observed in vivo. We thus treated a patient affected by acute idiopathic pericarditis and glucose 6-phosphate dehydrogenase deficiency with sodium salicylate, obtaining complete resolution of fever and symptoms, without any hemolytic complication. Therapy with sodium salicylate could thus be a safe and effective alternative for patients with glucose 6-phosphate dehydrogenase who require anti-inflammatory therapy.
Istituto di Clinica Medica Generale e Cardiologia, Università degli Studi di Firenze.
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Tedeschini
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Ruggiano
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Sofo
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Poggesi
D000208:Acute Disease; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D005953:Glycogen Storage Disease Type I / Q000150:complications*; D006801:Humans; D008297:Male; D010493:Pericarditis / Q000150:complications* / Q000188:drug therapy*; D012008:Recurrence; D012980:Sodium Salicylate / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012980:Sodium Salicylate