A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons.
Bühler
L
L
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02129, USA.
Awwad
M
M
Basker
M
M
Gojo
S
S
Thall
A
A
Down
J D
JD
Sykes
M
M
Andrews
D
D
Sackstein
R
R
White-Scharf
M E
ME
Sachs
D H
DH
Cooper
D K
DK
D000818:Animals; D000917:Antibody Formation; D019013:CD40 Antigens / Q000276:immunology; D023201:CD40 Ligand; D003169:Complement Inactivator Proteins / Q000494:pharmacology; D016572:Cyclosporine / Q000627:therapeutic use; D004546:Elapid Venoms / Q000494:pharmacology; D018380:Hematopoietic Stem Cell Transplantation; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy / Q000379:methods*; D007937:Leukapheresis; D007959:Lymphocyte Culture Test, Mixed; D008212:Lymphocyte Depletion; D008562:Membrane Glycoproteins / Q000276:immunology*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010215:Papio; D013156:Splenectomy; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology; D014183:Transplantation, Heterologous / Q000276:immunology*; D014916:Whole-Body Irradiation
D019013:CD40 Antigens; D003169:Complement Inactivator Proteins; D004546:Elapid Venoms; D008562:Membrane Glycoproteins; C016310:cobra venom factor; D023201:CD40 Ligand; D016572:Cyclosporine; D009173:Mycophenolic Acid