A specific role for cyclin D1 in mammary gland development.
Cyclin D1 is a critical component of the core cell cycle machinery. Mice lacking cyclin D1 develop mammary glands that fail to undergo normal lobuloalveolar proliferation during pregnancy. Thus, cyclin D1 seems to play a critical role in pregnancy-induced proliferation of mammary epithelium. Cyclin D1 also participates in neoplasia, as the majority of human mammary carcinomas contain elevated levels of this cyclin.
Sicinski
P
P
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA.
Weinberg
R A
RA
D000818:Animals; D019938:Cyclin D1 / Q000502:physiology*; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000196:embryology* / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011247:Pregnancy
D019938:Cyclin D1