Penetration by a giant gastric ulcer induced by a nonsteroidal anti-inflammatory drug.
A patient presented with penetration by a giant gastric ulcer resulting from treatment with a nonsteroidal anti-inflammatory drug. A test for Helicobacter pylori proved negative. Treatment with a combination of an inhibitor of gastric acid secretion and prostaglandin substitution therapy with misoprostol resulted in closure of the perforation and cicatrization of the gastric ulcer without the need for laparotomy.
Shimizu
I
I
Second Dept. of Internal Medicine, School of Medicine, University of Tokushima, Japan. shimizui@clin.med.tokushima-u.ac.jp
Horie
T
T
Inoue
H
H
Oshima
T
T
Fujimoto
M
M
Ozaki
Y
Y
Yamamoto
K
K
Iuchi
A
A
Ito
S
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D005773:Gastroscopy; D006801:Humans; D008134:Long-Term Care; D017116:Low Back Pain / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000139:chemically induced*; D013276:Stomach Ulcer / Q000139:chemically induced*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac