Actinic keratosis is squamous cell carcinoma.
BACKGROUND
The prevalence of nonmelanoma skin cancer in the United States is alarming. It can be most appropriately treated if the earliest manifestation of cutaneous squamous cell carcinoma is recognized.


METHODS
Clinical, histologic, and molecular biology, considerations were reviewed to determine whether actinic keratosis is the earliest clinical manifestation of cutaneous squamous cell carcinoma.


RESULTS
The clinical, histologic, and molecular parameters of actinic keratosis are those of squamous cell carcinoma.


CONCLUSIONS
Actinic keratosis does not transform, convert, or progress into cutaneous squamous cell carcinoma but is the earliest clinically recognizable manifestation of this malignancy.
Lober
B A
BA
Division of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, USA.
Lober
C W
CW
D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D007642:Keratosis / Q000235:genetics / Q000473:pathology*; D008967:Molecular Biology; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000473:pathology; D015995:Prevalence; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*; D009626:Terminology as Topic