Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism, coronary thrombosis, and myocardial infarction in middle-aged Finnish men who died suddenly.
High plasminogen activator inhibitor-1 (PAI-1) plasma levels increase future risk of myocardial infarction (MI). The 4G allele of the 4G/5G polymorphism of the PAI-1 gene has been associated with increased plasma levels of PAI-1. The association of the PAI-1 polymorphism with coronary narrowings, coronary thrombosis and myocardial infarction (MI) was studied in a prospective autopsy series of 300 middle-aged Caucasian Finnish men (33 to 69 yrs) suffering sudden out-of-hospital death (Helsinki Sudden Death Study). The 4G allele was found in 76.8% of men with sudden cardiac death (SCD) compared to 67.5% in men who died accidentally and 63.2% in men who died of other diseases (p = 0.08 and p = 0.055, respectively). Men possessing the 4G allele had more often acute MI (OR 3.5; p <0.05) and coronary thrombosis (OR 5.5. p = 0.01) compared to 5G homozygotes. 5G homozygotes, comprising one third of the men in our study, seem to be at a decreased risk of thrombosis, whereas carriers of the common 4G allele have an increased risk of thrombosis, AMI and possibly SCD compared to 5G homozygotes.
Medical School, University of Tampere and Tampere University Hospital, Finland. jm56215@uta.fi
J
J
Mikkelsson
M
M
Perola
U
U
Wartiovaara
L
L
Peltonen
A
A
Palotie
A
A
Penttilä
P J
PJ
Karhunen
D000059:Accidents / Q000401:mortality; D000483:Alleles; D001344:Autopsy; D002423:Cause of Death; D015897:Comorbidity; D003327:Coronary Disease / Q000150:complications / Q000473:pathology; D003328:Coronary Thrombosis / Q000235:genetics / Q000401:mortality*; D003331:Coronary Vessels / Q000473:pathology; D003645:Death, Sudden / Q000453:epidemiology*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics / Q000401:mortality*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012306:Risk; D012907:Smoking / Q000453:epidemiology; D013405:Suicide / Q000706:statistics & numerical data
D017395:Plasminogen Activator Inhibitor 1