T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling.
Recognition of antigen by T cells in the periphery may lead either to the generation of productive immunity or the induction of tolerance. These two functional outcomes are a consequence of distinct pathways of T-cell differentiation. T cells are selected to become regulatory cells and their function is to maintain homeostasis with the immune system. In this review we discuss the cell-fate decisions that T cells might make allowing them to promote immunity or induce tolerance in the context of the role that Notch signalling may play in this process.
Hoyne
G F
GF
Immunobiology Group, MRC Centre for Inflammation Research and the Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, UK.
Dallman
M J
MJ
Lamb
J R
JR
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D051880:Receptors, Notch; D015398:Signal Transduction / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D008565:Membrane Proteins; D051880:Receptors, Notch