[Antithrombotic activity of para-aminobenzoic acid].
Mechanisms of the anticoagulant activity of p-aminobenzoic acid (PABA) were studied. The specific antithrombin activity of PABA is aIIa = 7.00 +/- 0.32 IU/mg and the specific antiactivated factor Xa activity is aXa = 6.70 +/- 0.12 IU/mg. Study of the antithrombotic activity of PABA in rats with a model of venous stasis showed that intravenous injection of PABA at a dose of 1.5 mg/kg prevented the experimental thrombosis development 1.5 h after injection. The activity exhibited a peak 3 h after drug injection and ceased by the 5th hour. Equal antithrombotic activity in the rat blood plasma was observed for fraxiparin at a dose of 40 aXa IU/kg and PABA at 25 aXa IE/kg (1.5 mg/kg). At the same time, PABA affected neither the number of thrombocytes nor their response to the thrombocyte aggregation factors (ADP or adrenaline).
Laboratory of Hemostasis Pathology and Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
N N
NN
Drozd
V A
VA
Makarov
N T
NT
Miftakhova
S A
SA
Kalugin
O G
OG
Stroeva
S I
SI
Akberova
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D000818:Animals; D015951:Factor Xa / Q000378:metabolism; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D020246:Venous Thrombosis / Q000517:prevention & control
D005343:Fibrinolytic Agents; D015951:Factor Xa; D010129:4-Aminobenzoic Acid