Na,K-ATPase in the myocardium: molecular principles, functional and clinical aspects.
The role that Na,K-ATPase plays in Na+ and K+ antiport through the sarcolemma, in cation-homeostasis in cardiomyocytes as well as in excitation-contraction coupling and cell signalling in the myocardium is now widely recognized. It was its key importance for the cell membrane function that kept this enzyme intensively studied during the last three decades and finally brought to its discoverer the deserved Nobel Prize. Almost weekly are appearing new data concerning structure, function, regulation and role of the Na,K-ATPase in different physiological and pathological conditions. The special importance of the enzyme for heart function as well as the great amount of data that is concerned specifically with the heart Na,K-ATPase and accumulated since yet, started to call for setting them in order. The present paper updates basically important data on the cardiac Na,K-ATPase in relation to its specific properties, molecular mechanisms of function, mode of action, humoral and pharmacological modulation, adaptability, physiological role and clinical aspects.
Institute for Heart Research, Slovak Academy of Sciences, Bratislava. usrdzigy@savba.savba.sk
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Ziegelhöffer
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Kjeldsen
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Bundgaard
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Breier
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Vrbjar
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Dzurba
D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D002412:Cations; D002478:Cells, Cultured; D003920:Diabetes Mellitus / Q000201:enzymology; D006801:Humans; D000860:Hypoxia; D007511:Ischemia; D007700:Kinetics; D008024:Ligands; D008274:Magnesium / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D020033:Protein Isoforms; D017433:Protein Structure, Secondary; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology*
D002412:Cations; D008024:Ligands; D020033:Protein Isoforms; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D008274:Magnesium; D011188:Potassium; D002118:Calcium