Tbx12, a novel T-box gene, is expressed during early stages of heart and retinal development.
T-box genes encode transcription factors that regulate many developmental processes. We have cloned a novel mouse T-box gene, Tbx12. Tbx12 is the vertebrate homologue of the Drosophila H15 gene and the Caenorhabditis elegans tbx-12 gene. Tbx12 is expressed in extraembryonic tissues such as the amnion and allantois. In the embryo, Tbx12 is strongly expressed in the neural retina and the heart.
Carson
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MCD Biology, University of Colorado, Boulder, CO 80309-0347, USA.
Kinzler
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Parr
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D000482:Allantois / Q000378:metabolism; D000595:Amino Acid Sequence; D000650:Amnion / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000196:embryology; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000196:embryology; D004622:Embryo, Mammalian / Q000378:metabolism; D004625:Embryo, Nonmammalian; D006321:Heart / Q000196:embryology*; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D012160:Retina / Q000196:embryology*; D020825:T-Box Domain Proteins; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D020825:T-Box Domain Proteins; C486013:Tbx20 protein, mouse; D014157:Transcription Factors