Epitopes on Rh proteins.
Analyses of the reactions of monoclonal anti-D with Rh D variant red cells have shown that there are at least 24 different epitopes of the Rh D antigen. Similar studies Of Rh E variant red cells with monoclonal anti-E indicate that there are at least 4 epitopes of the Rh E antigen. The relation of these serologically defined epitopes to the structure of the Rh proteins is reviewed. Most epitopes are discontinuous, with critical residues present in different loops of the proteins.
Bristol Institute for Transfusion Sciences, UK. marion.scott@nbs.nhs.uk
M L
ML
Scott
D
D
Voak
W
W
Liu
J W
JW
Jones
N D
ND
Avent
D000941:Antigens / Q000737:chemistry / Q000276:immunology; D018604:Epitope Mapping; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D006801:Humans; D012204:Rh-Hr Blood-Group System / Q000737:chemistry / Q000276:immunology*; D012698:Serologic Tests
D000941:Antigens; D000939:Epitopes; D012204:Rh-Hr Blood-Group System