Evaluation of antidiarrhoeal profile of Jussiaea suffruticosa linn. extract in rats.
The antidiarrhoeal potential of a methanol extract of the aerial parts of Jussiaea suffruticosa Linn. (MEJS) was studied with several experimental models of diarrhoea in rats. MEJS treated rats showed significant inhibitory activity against castor oil induced diarrhoea and PGE(2) induced enteropooling. It also showed a significant reduction in gastrointestinal motility following a charcoal meal in rats. The extract exhibited significant antidiarrhoeal potential at doses of 100,200 and 300 mg/kg in all the animal models and thus established the efficacy of MEJS as a potent antidiarrhoeal agent.
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
T
T
Murugesan
L
L
Ghosh
K
K
Mukherjee
J
J
Das
M
M
Pal
B P
BP
Saha
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy*; D015232:Dinoprostone / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D007194:India; D007928:Lethal Dose 50; D008297:Male; D008518:Medicine, East Asian Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales / Q000737:chemistry / Q000627:therapeutic use* / Q000633:toxicity
D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil; D015232:Dinoprostone