The hypocretin/orexin story.
Newly described peptides, produced in neurons in the lateral hypothalamic area, have been shown to stimulate appetite and stereotypic behaviors associated with feeding. Discovered independently by two groups, the hypocretins/orexins stimulate autonomic function and have been shown to be physiological regulators of the arousal state. Neuroendocrine and metabolic effects of these peptides, some related to sleep-wakefulness and arousal state, are just now being discovered.
Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63131, USA. samsonwk@slu.edu
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D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000235:genetics / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000235:genetics / Q000502:physiology*; D000068797:Orexins
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D000068797:Orexins