Coagulation products and their uses.
The indications, pharmacokinetics, and therapeutic guidelines for available coagulation products are reviewed. Patients with hemophilia, von Willebrand's disease (VWD), or acquired inhibitors to antihemophilic factor (AHF) cannot spontaneously stop an acute hemorrhage. Coagulation products used to manage bleeding in patients with these disorders include AHF concentrates, factor IX concentrates, factor VIIa concentrate, factor IX complexes, anti-inhibitor coagulant complexes, and desmopressin acetate. Typically, these commercially available products are used to manage acute bleeding or to prevent excessive bleeding during surgery. The dosage of the coagulation products and the duration of therapy depend on many variables, including the severity of the hemorrhage, the pharmacokinetics of the coagulation products, and patient-specific factors. Product purity and viral attenuation are also important considerations in determining an appropriate dosage regimen. Recombinant versions of some coagulant factors are available and can eliminate the risk of viral transmission. A thorough understanding of each coagulation product can guide product selection, dosing, and treatment duration and can reduce the risk of viral transmission.
Division of Pharmacotherapy, School of Pharmacy, University of North Carolina at Chapel Hill 27599-7360, USA. celeste_lindley@unc.edu
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D000818:Animals; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use*; D005164:Factor IX / Q000009:adverse effects / Q000627:therapeutic use*; D005169:Factor VIII / Q000009:adverse effects / Q000627:therapeutic use*; D006467:Hemophilia A / Q000628:therapy*; D006487:Hemostasis; D006801:Humans; D013552:Swine; D014842:von Willebrand Diseases / Q000628:therapy*
D005169:Factor VIII; D005164:Factor IX; D003894:Deamino Arginine Vasopressin