[The predominant expression of Th2 type cytokines in human tumor cells].
OBJECTIVE
To observe the expression of Th1 versus Th2 type cytokines in human tumor cells.


METHODS
The gene expression of Th1/Th2 cytokines in human tumor cells was detected by RT-PCR and RNA dot hybridization using IL-2 and IFN gamma as Th1 type cytokine genes, IL-4, IL-10 and IL-13 as Th2 type cytokine genes.


RESULTS
There were predominant expressions of Th2 type cytokines in 20 different human tumor cell lines including 11 solid tumor and 9 hematogenous tumor cells.


CONCLUSIONS
Predominant expression of Th2 type cytokines by tumor cells may be related to the evasion of tumor cells from immune surveillance.
Shandong Cancer Biotherapy Center, Shandong Academy of Medical Sciences, Jinan.
J
J
Liu
Z
Z
Tian
R
R
Sun
D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D018793:Interleukin-13 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology; D008223:Lymphoma / Q000378:metabolism / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000378:metabolism*
D016207:Cytokines; D018793:Interleukin-13; D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma