[Clinical evaluation of several tumor markers in the diagnosis of primary hepatic cancer].
OBJECTIVE
To evaluate the practical significance of alphafetoprotein(AFP), alpha-L-fucosidase(AFu), gamma-glutamyltransferase(GGT), sialic acid(SA) and carcinoembryonic antigen(CEA) in the diagnosis of primary hepatic cancer(PHC).


METHODS
AFP, AFu, GGT, SA and CEA in the serum were studied in 67 patients with PHC, 8 with hepatic metastasis of gastrointestinal cancer, 89 with benign liver diseases and in 131 controls without liver diseases.


RESULTS
According to statistics, the sensitivity of AFP, AFu, GGT, SA and CEA in the diagnosis of PHC was 65.4%, 70.8%, 34.8%, 60.2% and 36.4% repectively; their specificity was 92.6%, 98.1%, 87.1%, 94.5% and 77.8% respectively. CEA in hepatic metastasis of gastrointestinal cancer was higher than that in the other groups of patients. Simultaneous detection of AFP, AFu GGT and CEA gave a diagnostic sensitivity and specificity in PHC of 81.4% and 91.6% respectively.


CONCLUSIONS
AFP and AFu are superior to GGT, SA and CEA in the diagnosis of PHC; simultaneous detection of AFP, AFu, GGT and SA might increase the diagnositic sensitivity and specificity of PHC. CEA was less helpful in the diagnosis of PHC, but might be used to differentiate PHC from hepatic metastasis of gastrointestinal cancer.
Dept. of Gastroenterology, 2nd Hospital, Hubei Medical University, Wuhan.
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Shi
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Zhou
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Xia
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000097:blood; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000378:metabolism; D005644:alpha-L-Fucosidase / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins; D005723:gamma-Glutamyltransferase; D005644:alpha-L-Fucosidase; D019158:N-Acetylneuraminic Acid