[Microscopic polyangiitis accompanying interstitial pneumonia with aluminum lung].
A 67-year-old man who had worked as an aluminum grinder had been given a diagnosis of pneumoconiosis. Ten years later, he was admitted with fever, dyspnea on exertion, and numbness. Chest roentgenograms showed linear-reticular shadows in both lower lung fields. ELISA-based tests were positive for perinuclear anti-neutrophil cytoplasmic antibody (P-ANCA). Renal biopsy specimens disclosed crescentic glomerulonephritis and angiitis of small arteries. Our diagnosis was microscopic polyangiitis accompanying interstitial pneumonia with aluminum lung. The results of high-energy dispersion X-ray microanalysis indicated that the patient's lungs contained aluminum. His general condition improved with the administration of corticosteroid and immunosuppressive agents, and his chief symptoms disappeared.
Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
M
M
Seike
T
T
Enomoto
S
S
Henmi
K
K
Uematsu
A
A
Azuma
A
A
Yoshimura
Y
Y
Takasaki
H
H
Mochimaru
Y
Y
Fukuda
S
S
Kudoh
D000368:Aged; D000535:Aluminum; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008669:Metallurgy; D011009:Pneumoconiosis / Q000150:complications* / Q000188:drug therapy; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone; D000535:Aluminum