Non-thermal effects of continuous 2.45 GHz microwaves on Fas-induced apoptosis in human Jurkat T-cell line.
Non-thermal effects of microwaves (MWs) are one of the main issues studied for revising standards. The effects of MW exposure on apoptosis at non-thermal level (48 h, 2.45 GHz, 5 mW/cm2) have been studied. Results obtained assess non-thermal MW effects on Fas, but neither on butyrate- nor on ceramide-induced apoptosis in human Jurkat T-cell line. These data show that MW interacts either with Fas pathway between receptor and caspase-3 activation or on membrane proteins (i.e. Fas receptor or neurosphyngomyelinase).
Peinnequin
A
A
CRSSA-RBI, La Tronche, France. a_peinnequin@compuserve.com
Piriou
A
A
Mathieu
J
J
Dabouis
V
V
Sebbah
C
C
Malabiau
R
R
Debouzy
J C
JC
D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D002087:Butyrates / Q000494:pharmacology; D002518:Ceramides / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D019169:Jurkat Cells; D008872:Microwaves; D013601:T-Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D019014:fas Receptor / Q000502:physiology*
D002087:Butyrates; D002518:Ceramides; D019014:fas Receptor