[Brain ischemia induced by gravitational overload].
It is suggested that radial gravitational overloads in craniocaudal direction, during which the pressure in meningeal arteries drops to zero, can be used to model the ischemic state. The post-ischemic period is characterized by increasing content of lipid peroxidation products in the venous blood and by violation of the neurological state in rats. This ischemia model, requiring no anaesthesia for the experimental animals, can be used in the directed search for new neuroprotectors and their characterization.
Gaevyĭ
M D
MD
Pharmacology Department, State Pharmaceutical Academy, Pyatigorsk, Russia.
Adzhienko
L M
LM
Makarova
L M
LM
Abdulsalam
A A
AA
D000818:Animals; D001522:Behavior, Animal; D002545:Brain Ischemia / Q000209:etiology / Q000378:metabolism* / Q000523:psychology*; D018470:Gravity, Altered / Q000009:adverse effects*; D015227:Lipid Peroxidation; D018696:Neuroprotective Agents / Q000494:pharmacology; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances; D014748:Vinca Alkaloids / Q000494:pharmacology
D018696:Neuroprotective Agents; D017392:Thiobarbituric Acid Reactive Substances; D014748:Vinca Alkaloids; C013983:vinpocetine