Hypoglycemic effects of lactucin-8-O-methylacrylate of Parmentiera edulis fruit.
Hypoglycemic activity-guided fractionation together with chemical analysis led to the isolation of one guaianolide (lactucin-8-O-methylacrylate) from the chloroform extract of the dried fruits of Parmentiera edulis. Identification was based on spectroscopic methods. The compounds lowers blood sugar levels after administration to alloxan-diabetic mice.
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Laboratorio de Investigacion de Productos Naturales, Escuela Superior de Ingeniería Química e Industias extractivas IPN, Punto fijo 16, col, cp 07708, Torres Lindavista, Mexico. dmex@df1.telmex.net.mx
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Zavala
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Hernandez
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Lagunes
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D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*
D007004:Hypoglycemic Agents; D008689:Methacrylates; C440988:lactucin-8-O-methylacrylate; D000496:Alloxan