New quinoline alkaloids from Ruta chalepensis.
The roots of Ruta chalepensis, collected from the northern Saudi desert, yielded two new quinoline alkaloids, namely, 2-¿6'-(2H-benzo[d]1' ',3' '-dioxolen-5' '-yl)hexyl¿-hydroquinolin-4-one (1) and 2-¿6'-(2H-benzo[d]1' ',3' '-dioxolen-5' '-yl)hexyl¿-4-methoxy-quinoline (2). Nine previously reported alkaloids, dictamnine, pteleine, skimmianine, rutacridone, isogravacridonechlorine, maculosidine, graveoline, graveolinine, and 4-methoxy-1-methyl-2(1H)-quinolinone, and coumarins, chalepensin, and umbelliferone were also isolated. Structure elucidations were based primarily on 1D and 2D NMR analyses and chemical transformations. Antimicrobial activity of these compounds is discussed.
Medicinal, Aromatic and Poisonous Plants Research Center and Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
K
K
El Sayed
M S
MS
Al-Said
F S
FS
El-Feraly
S A
SA
Ross
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D013057:Spectrum Analysis
D000470:Alkaloids; D011804:Quinolines