Changes in 5-HT(7) serotonin receptor mRNA expression with aging in rat brain.
We examined 5-HT(7) receptor mRNA expression with in situ hybridization histochemistry in the brains of young (3 months), middle-aged (12 months) and old rats (24 months). In the ventral CA3 area of the hippocampus 5-HT(7) mRNA expression is reduced by approximately 30% between young and middle age without further decline between middle and old age. In other brain areas 5-HT(7) mRNA expression is unaffected by age.
Kohen
R
R
VA Puget Sound Health Care System, Geriatric Research, Education and Clinical Center, GRECC-182B, Seattle, WA 98108, USA. ruko@u.washington.edu
Heidmann
D E
DE
Anthony
J
J
White
S S
SS
Hamblin
M W
MW
Szot
P
P
D000375:Aging / Q000235:genetics*; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D017966:Pyramidal Cells / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011914:Rats, Inbred BN; D011985:Receptors, Serotonin / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D012333:RNA, Messenger; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor