Localization of G-protein-coupled receptors in health and disease.
G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The broad range of physiological functions associated with GPCRs indicates that a better understanding of these receptors and their regulation can provide a solid foundation for novel pharmacological interventions in a variety of disease states.
National Center for Biotechnology Information, NLM, NIH, 8600 Rockville Pike, Room 8N805, Building 38A, Bethesda, MD 20894, USA. Edwards@ncbi.nlm.nih.gov
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D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D003550:Cystic Fibrosis / Q000209:etiology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000502:physiology; D003919:Diabetes Insipidus / Q000209:etiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D011956:Receptors, Cell Surface / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D011973:Receptors, LDL / Q000032:analysis; D012174:Retinitis Pigmentosa / Q000209:etiology
C505032:CFTR protein, human; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D019204:GTP-Binding Proteins