[Nitric oxide inhalation in the treatment of acute respiratory distress syndrome].
OBJECTIVE
To investigate the role of nitric oxide (NO) in acute respiratory distress syndrome (ARDS).


METHODS
Ten patients with ARDS underwent Swan-Ganz catheterization and mechanical ventilation. Before and after inhalation of 35 ppmNO, hemodynamic, blood gas and DO2 parameters were examined.


RESULTS
After inhaling NO, mPAP and PVR were significantly reduced from 3.6 +/- 0.6 kPa to 2.7 +/- 0.5 kPa and from 32 +/- 11 kPa.s-1.L-1 to 22 +/- 9 kPa.s-1.L-1 respectively (P < 0.001). CO, BP and SVR were not significantly different (P > 0.05). Qs/Qt and P(A-a)O2 were decreased from 31% +/- 9% to 25% +/- 8% and from 37 +/- 6 kPa to 34 +/- 6 kPa respectively (P < 0.01). PaO2 and SaO2 were increased from 12 +/- 3 kPa to 15 +/- 5 kPa and from 95% +/- 3% to 96% +/- 3% respectively (P < 0.05, P < 0.001).


CONCLUSIONS
In the treatment of ARDS, inhalation of NO can have a better effect.
Department of Respiratory Disease, Guangdong Provincial People's Hospital.
X
X
Gao
S
S
Huang
D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D009569:Nitric Oxide