The ameliorating effects of the cognitive-enhancing Chinese herbs on scopolamine-induced amnesia in rats.
Ameliorating effects were investigated of the cognitive-enhancing Chinese herbs administered orally for 1 week-Panax ginseng (PG), Panax notoginseng (PNG), Dioscorea opposita (DO), Gastrodia elata (GE), Salvia miltiorrhiza (SM), Acorus gramineus (AG), Coptis chinensis (CC), Polygonum multiflorum (PM), Cyperus rotundus (CR) and Psoralea corylifolia (PC)-on the scopolamine (SCOP)-induced amnesia by using a passive avoidance task in rats. Of ten Chinese herbs, only PG, PNG, GE and CC prolonged the SCOP-shortened STL. These results revealed that PG, PNG GE and CC administered orally for 1 week improved the SCOP-induced learning and memory deficit in rats.
Hsieh
M T
MT
Institute of Chinese Pharmaceutical Sciences, China Medical College, Taiwan, R.O.C. rei106@tcts1.seed.net.tw
Peng
W H
WH
Wu
C R
CR
Wang
W H
WH
D000284:Administration, Oral; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008568:Memory / Q000187:drug effects*; D018727:Muscarinic Antagonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine
D004365:Drugs, Chinese Herbal; D018727:Muscarinic Antagonists; D012601:Scopolamine