[Effect of calcitonin gone-related peptide on coronary thrombosis and thrombolytic therapy].
OBJECTIVE
To inverstigate the effect of Caleitonin gene-related peptide (CGRP) on intracoronary thrombosis, thrombolysis, and reocclusion.


METHODS
Thirty-six dogs were divided into three groups: saline solution (NS) group, nitroglycerin(NTG) group and CGRP group. The canine model of intracoronary thrombsis was established. Urokinase(UK) was administered intravenously. The time and rate of intracoronary thrombosis, patency and reocclusion were observed.


RESULTS
The time of thrombus formation was markedly prolonged in the CGRP group. (NS 41 +/- 9 min, CGRP 72 +/- 11 min P < 0.01). The time of patency was shorted from 80 +/- 7 min(NS), 70 +/- 11 min(NTG) to 50 +/- 9 min(CGRP) (P < 0.01). The time of reocclusion was increased from 20 +/- 10 min(NS), 39 +/- 7 min(NTG) to 65 +/- 12 min(CGRP)(P < 0.01).


CONCLUSIONS
CGRP can delay the intracoronary thrombus formation, assist thrombolysis and decrease the reocclusis after thrombolysis.
First Hospital of Norman Bethune University of Medical Sciences, Chang chun.
Y
Y
Zheng
L
L
Zhao
X
X
Yang
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000627:therapeutic use*; D003328:Coronary Thrombosis / Q000188:drug therapy / Q000517:prevention & control*; D004285:Dogs; D011897:Random Allocation; D055502:Secondary Prevention; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D014568:Urokinase-Type Plasminogen Activator; D015740:Calcitonin Gene-Related Peptide