SCID mice show a similar susceptibility to Angiostrongylus cantonensis as do wild-type mice of the C.B-17 strain.
C.B-17-SCID/SCID (SCID) mice infected with Angiostrongylus cantonensis yielded a high percentage of worm recovery and did not show any body weight loss until day 24 postinfection. Unexpectedly, C.B-17-+/+(+/+) mice also produced a similar worm burden containing well-developed worms. This is probably attributable to the observation that +/+ mice failed to induce eosinophilia in cerebrospinal fluid (CSF) despite their production of antigen-specific IgA and IgGI; +/+ mice have defective bone-marrow eosinopoiesis, which in turn results in reduced blood and CSF eosinophilia. Interleukin 5 (IL-5) production in +/+ mice is similar to that in BALB/c and C57BL/6 mice. However, bone-marrow eosinopoiesis in response to IL-5 is markedly suppressed in +/+ mice. This is probably associated with impaired expression of common beta-chain mRNA in bone-marrow cells of +/+ mice, which leads to the failure of bone-marrow eosinopoiesis. Hence, +/+ mice may serve as a useful model for the elucidation of eosinophil production in the mouse and for determination of the relationship between parasite infection and the eosinophil.
Department of Parasitology, Akita University School of Medicine, Japan. kenyoshi@med.akita-u.ac.jp
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Yoshimura
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Sugaya
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Aoki
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Ishida
D017185:Angiostrongylus cantonensis / Q000276:immunology* / Q000472:pathogenicity; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology; D001700:Biomphalaria; D001853:Bone Marrow; D004198:Disease Susceptibility; D004802:Eosinophilia; D015870:Gene Expression; D007377:Interleukin-3 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D007962:Leukocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D016513:Mice, SCID / Q000276:immunology*; D009017:Morbidity; D051381:Rats; D018123:Receptors, Interleukin / Q000235:genetics; D016185:Receptors, Interleukin-3 / Q000235:genetics; D053649:Receptors, Interleukin-5; D017206:Strongylida Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007377:Interleukin-3; D015848:Interleukin-5; D018123:Receptors, Interleukin; D016185:Receptors, Interleukin-3; D053649:Receptors, Interleukin-5