Physiology of a microgravity environment selected contribution: effects of spaceflight during pregnancy on labor and birth at 1 G.
The events of parturition (labor, delivery, maternal care, placentophagia, and onset of nursing) were analyzed in female Norway rats (Rattus norvegicus) flown on either 11- or 9-day-long spaceflights beginning at the approximate midpoint of their pregnancies. Each space shuttle flight landed on the 20th day of the rats' pregnancies, just 48-72 h before parturition. After spaceflight, dams were continuously monitored and recorded by time-lapse videography throughout the completion of parturition and onset of nursing (days 22 and 23). Analyses of parturition revealed that, compared with ground controls, flight dams displayed twice the number of lordosis contractions, the predominant labor contraction type in rats. The number of vertical contractions (those that immediately precede expulsion of a pup from the womb), the duration of labor, fetal wastage, number of neonates born, neonatal birth weights, placentophagia, and maternal care during parturition, including the onset of nursing, were comparable in flight and ground control dams. Our findings indicate that, with the exception of labor contractions, mammalian pregnancy and parturition remain qualitatively and quantitatively intact after spaceflight during pregnancy.
Life Sciences Division, National Aeronautics and Space Administration Ames Research Center, Moffett Field, California 94035, USA. aronca@mail.arc.nasa.gov
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Ronca
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Alberts
D000222:Adaptation, Physiological; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D003624:Darkness; D005260:Female; D005333:Fetus / Q000502:physiology; D007044:Hysterectomy; D007743:Labor, Obstetric / Q000502:physiology* / Q000523:psychology; D008027:Light; D008425:Maternal Behavior / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology* / Q000523:psychology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013026:Space Flight; D014893:Weightlessness / Q000009:adverse effects*