Prospects for vaccination in prostate cancer.
Prostate cancer continues to be a major cause of morbidity and mortality. Surgical and medical management of the disease has improved but there is little effect upon overall survival. Novel therapies such as immunotherapy offer the potential of treating the disease by stimulating the immune system to mount a response to the cancer systemically. This review highlights the pitfalls and progress in the understanding of the role of the immune system in malignancy and also explains the theory behind prostate cancer vaccine trials.
Perry
M J
MJ
Department of Urology and Oncology, St George's Hospital, Medical School, London, England. mnvperry@globalnet.co.uk
Hroulda
D
D
Dalgleish
A G
AG
D017951:Antigen Presentation; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination