Kidney transplantation in dogs with naturally occurring end-stage renal disease.
Renal allografts were performed between unrelated donors and 15 dogs with naturally occurring end-stage renal disease. Donor selection was based on compatible dog erythrocyte antigen typing and cross-matching. An immunosuppressive protocol consisting of rabbit antidog antithymocyte serum, cyclosporin-A, azathioprine, and prednisone was used to control postoperative rejection of the donated kidney. Although seven animals died because of technical failures or rejection episodes, a median survival time of eight months has been achieved, with two dogs living for longer than five years after surgery. Long-term survivors have died from a variety of problems not related to renal allograft rejection.
Mathews
K A
KA
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada.
Holmberg
D L
DL
Miller
C W
CW
D000818:Animals; D004283:Dog Diseases / Q000401:mortality / Q000601:surgery*; D004285:Dogs; D007165:Immunosuppression Therapy / Q000662:veterinary*; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000662:veterinary*; D016030:Kidney Transplantation / Q000401:mortality / Q000662:veterinary*; D009864:Ontario / Q000453:epidemiology; D011182:Postoperative Care / Q000662:veterinary; D016019:Survival Analysis