A genome-wide map showing common regions of loss of heterozygosity/allelic imbalance in breast cancer.
We report here a new framework map that integrates data from 143 studies on the loss of heterozygosity/allelic imbalance in breast cancer. Full details of these loss of heterozygosity maps can be found at the web site (http://www.nottingham.ac.uk/pdzmgh/loh/) that accompanies this report. By combining results from these data, we have also been able to highlight and identify minimum commonly deleted regions on each chromosome. In addition to finding commonly deleted regions at both the BRCA1 and BRCA2 loci, which confirmed the power of the technique, 24 other regions were identified on 16 different chromosomes.
Osborne
R J
RJ
Institute of Genetics, Queen's Medical Centre, University of Nottingham, United Kingdom.
Hamshere
M G
MG
D000483:Alleles; D024682:BRCA2 Protein; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D019398:Genes, BRCA1 / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D019656:Loss of Heterozygosity; D009363:Neoplasm Proteins / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D014157:Transcription Factors / Q000235:genetics
D024682:BRCA2 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors