Spectrophotometric studies and application of imipramine-eriochrome cyanine R system for determination of imipramine in pharmaceuticals.
Eriochrome cyanine R (ECR) has been tested as reagent for the determination of imipramine. It reacts in neutral medium with imipramine forming reddish compound, which can be quantitatively extracted into n-butanol. This property has been successfully used for the extractive-spectrophotometric determination of imipramine. Beer's law is obeyed in concentration range of 10-80 microg ml(-1) of imipramine. The method was applied to the determination of imipramine in its pharmaceutical.
Starczewska
B
B
Department of Chemistry, University of Bialystok, Poland.
D000929:Antidepressive Agents, Tricyclic / Q000032:analysis*; D001557:Benzenesulfonates / Q000032:analysis*; D007099:Imipramine / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000929:Antidepressive Agents, Tricyclic; D001557:Benzenesulfonates; D004364:Pharmaceutical Preparations; C010332:solochrome cyanine R; D007099:Imipramine