Lactogenic immunity following vaccination of cattle with bovine coronavirus.
In order to investigate the ability of an oil adjuvanted vaccine containing bovine coronavirus antigen to enhance lactogenic immunity in the calf, pregnant cows and heifers were vaccinated and specific virus neutralising antibody levels determined in serum, colostrum and milk. Pre-existing antibody titres (as a result of natural infection) in the serum of these animals were found to be significantly increased as a result of a single shot vaccination carried out between 2 and 12 weeks before calving. This was reflected in a similar increase in the titre and duration of specific antibody in milk and colostrum that was passed on to the calves. The overall response observed was highly dependent on an adequate antigen payload being incorporated within the single dose vaccine. No abnormal local or systemic reactions were observed as a result of vaccination. It is hoped that this approach will lead to the production of a superior commercial vaccine for the protection of neonatal calves against enteric coronavirus infection.
Schering Plough Animal Health, Breakspear Road South, Harefield, Middlesex UB9 6LS, Uxbridge, UK. colin.crouch@spcorp.com
C F
CF
Crouch
S
S
Oliver
D C
DC
Hearle
A
A
Buckley
A J
AJ
Chapman
M J
MJ
Francis
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000276:immunology; D002417:Cattle; D003126:Colostrum / Q000276:immunology*; D017934:Coronavirus / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D008892:Milk / Q000276:immunology*; D011247:Pregnancy; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D014765:Viral Vaccines