Renal effects of carprofen administered to healthy dogs anesthetized with propofol and isoflurane.
OBJECTIVE
To evaluate renal effects of carprofen in healthy dogs following general anesthesia.


METHODS
Randomized clinical trial.


METHODS
10 English hound dogs (6 females and 4 males).


METHODS
Dogs were randomly assigned to control (n = 5) or carprofen (5) groups. Anesthesia was induced with propofol (6 to 8 mg/kg [2.7 to 3.6 mg/lb] of body weight, i.v.) and maintained with isoflurane (end-tidal concentration, 2.0%). Each dog underwent two 60-minute anesthetic episodes with 1 week between episodes, and mean arterial blood pressure was maintained between 60 and 90 mm Hg during each episode. Dogs in the carprofen group received carprofen (2.2 mg/kg [1 mg/lb], p.o.) at 9:00 AM and 6:00 PM the day before and at 7:00 AM the day of the second anesthetic episode. Glomerular filtration rates (GFR) were determined during each anesthetic episode by use of renal scintigraphy. Serum creatinine and BUN concentrations and the urine gamma-glutamyltransferase-to-creatinine concentration (urine GGT:creatinine) ratio were determined daily for 2 days before and 5 days after general anesthesia.


RESULTS
Significant differences were not detected in BUN and serum creatinine concentrations, urine GGT:creatinine ratio, and GFR either between or within treatment groups over time.


CONCLUSIONS
Carprofen did not significantly alter renal function in healthy dogs anesthetized with propofol and isoflurane. These results suggest that carprofen may be safe to use for preemptive perioperative analgesia, provided that normal cardiorespiratory function is maintained.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
J C
JC
Ko
T
T
Miyabiyashi
R E
RE
Mandsager
T G
TG
Heaton-Jones
D F
DF
Mauragis
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001806:Blood Urea Nitrogen; D002227:Carbazoles / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood / Q000652:urine; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000662:veterinary; D007530:Isoflurane; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D015742:Propofol; D005723:gamma-Glutamyltransferase / Q000652:urine
D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D003404:Creatinine; D007530:Isoflurane; D005723:gamma-Glutamyltransferase; C007005:carprofen; D015742:Propofol