Immunohistochemical tenascin-C expression in paediatric supratentorial glioblastoma multiforme.
Tenascin-C (TN-C) plays an important part in the growth of neoplastic tissue, leading to new vessel development. TN-C has been assessed in adult glioblastoma multiforme (GBM) and has been evaluated as anti-neoplastic therapy. No studies have focused on this tissue in paediatric GBM. Tissues were obtained from six paediatric supratentorial GBMs. Immunohistochemistry was performed using a mouse antibody directed against human TN-C, and expression in tumour vasculature was described on the basis of TN-C immunoreactivity. The expression was minimal in three, moderate in two, and intense in one specimen. TN-C was not correlated with clinical history, neurological findings, or with tumour site. Although based on a limited number of patients, this study provides additional insights into tumour growth modulation and cytogenetic profile of paediatric GBM. The detailed understanding of events responsible for GBM growth is a prerequisite for the development of therapeutic modalities leading to improved prognosis and cure.
Neurosurgical Clinic--Policlinico, University of Messina School of Medicine, Italy. germano@unime.it
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A
Germanò
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S
Galatioto
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Caffo
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Caruso
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La Torre
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E
Cardia
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F
Tomasello
D002648:Child; D002675:Child, Preschool; D005260:Female; D005909:Glioblastoma / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015173:Supratentorial Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000532:radiotherapy; D019063:Tenascin / Q000378:metabolism*
D019063:Tenascin