Mitotic and in situ end-labeling apoptotic indices as prognostic markers in malignant mesothelioma.
The prognostic role of mitotic and apoptotic indices in 60 patients with malignant mesothelioma was examined on hematoxylin-eosin-stained sections. The findings were compared with apoptotic indices determined by in situ end labeling (ISEL) in 35 of the cases. There was a significant survival advantage associated with lower mitotic counts and a lower apoptotic index defined by ISEL (P < .05). There was no association between the apoptotic index derived from the hematoxylin-eosin-stained sections and prognosis (P = .90). However, there was a positive association between the apoptotic counts calculated from hematoxylin-eosin- and ISEL-stained sections (P < .01). The mitotic count and ISEL apoptotic index are potentially useful markers of prognosis in malignant mesothelioma.
Department of Histopathology, The Royal Hospital Haslar, Hampshire, UK.
T W
TW
Beer
N J
NJ
Carr
M A
MA
Whittaker
N
N
Pullinger
D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D001706:Biopsy; D004801:Eosine Yellowish-(YS); D005260:Female; D005500:Follow-Up Studies; D006416:Hematoxylin; D006801:Humans; D020287:In Situ Nick-End Labeling; D008297:Male; D008654:Mesothelioma / Q000473:pathology*; D008875:Middle Aged; D008940:Mitotic Index; D011379:Prognosis; D013194:Staining and Labeling; D016019:Survival Analysis
D004801:Eosine Yellowish-(YS); D006416:Hematoxylin