The removal of uremic toxins.
Three major groups of uremic solutes can be characterized: the small water-soluble compounds, the middle molecules, and the protein-bound compounds. Whereas small water-soluble compounds are quite easily removed by conventional hemodialysis, this is not the case for many other molecules with different physicochemical characteristics. Continuous ambulatory peritoneal dialysis (CAPD) is often characterized by better removal of those compounds. Urea and creatinine are small water-soluble compounds and the most current markers of retention and removal, but they do not exert much toxicity. This is also the case for many other small water-soluble compounds. Removal pattern by dialysis of urea and creatinine is markedly different from that of many other uremic solutes with proven toxicity. Whereas middle molecules are removed better by dialyzers containing membranes with a larger pore size, it is not clear whether this removal is sufficient to prevent the related complications. Larger pore size has virtually no effect on the removal of protein-bound toxins. Therefore, at present, the current dialytic methods do not offer many possibilities to remove protein-bound compounds. Nutritional and environmental factors as well as the residual renal function may influence the concentration of uremic toxins in the body fluids.
Renal Division, Department of Medicine, University Hospital of Gent, Gent, Belgium. Annemieke.Dhondt@rug.ac.be
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Dhondt
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Vanholder
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Van Biesen
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Lameire
D003404:Creatinine / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D006435:Renal Dialysis; D014508:Urea / Q000737:chemistry / Q000493:pharmacokinetics; D014511:Uremia / Q000378:metabolism* / Q000628:therapy*
D014508:Urea; D003404:Creatinine