[Effect of sodium nitrite on the activity of the neocortex neurons during realization of defense and inhibition conditioned reflexes].
A decrease in intensity and duration of short-latency reaction components of the sensorimotor and visual cortical neurons to specific stimuli (pain reinforcement and light flashes, respectively) was observed after the administration of NO-generating sodium nitrite (11 mg/kg, subcutaneously). Activation decrease in the visual cortex took place irrespective of biological significance of the light flashes, i.e., in case when this stimulus was a signal of defensive conditioning and in case when these flashes were applied with continuous light (a conditioned inhibitor). Sodium nitrite almost did not change the late activation of sensorimotor and visual neurons in response to pain reinforcement and disinhibitory action of the latter. The results confirm the viewpoint about different neurotransmitters in "specifically modal" and "non-specific" pathways to the neocortex during learning.
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
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Shul'gina
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D007266:Inhibition, Psychological; D009044:Motor Cortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D019579:Neocortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D010775:Photic Stimulation; D011817:Rabbits; D012977:Sodium Nitrite / Q000494:pharmacology*; D013003:Somatosensory Cortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D014793:Visual Cortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology
D020030:Nitric Oxide Donors; D012977:Sodium Nitrite