[Telomerase activity in human primary endometrial carcinoma].
OBJECTIVE
To investigate the possible relationship between telomerase expression and progression of endometrial carcinoma.


METHODS
Thirty-four primary endometrial carcinoma and 6 normal endometrial tissue specimens were examined by means of telomeric repeat amplification protocol (TRAP) assay for telomerase activity.


RESULTS
Of 34 endometrial cancer specimens, 28 (82.4%) showed telomerase activity, whereas 1 of 6 (16.7%) benign endometrial tissues exhibited telomerase activity.


CONCLUSIONS
Telomerase expression might contribute to the progression of endometrial carcinoma and could be used as its tumor marker.
Zhou
C
C
Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Sun
J
J
Jin
S
S
D000230:Adenocarcinoma / Q000201:enzymology*; D014408:Biomarkers, Tumor; D016889:Endometrial Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D019098:Telomerase / Q000378:metabolism*
D014408:Biomarkers, Tumor; D019098:Telomerase