[The role of omeprazole in the eradication of Helicobacter pylori in patients with duodenal ulcers].
BACKGROUND
This research study has tried to establish efficiency of omeprazole, in combination with two antibiotics (metronidazol and amoxicilin), with the aim to eradicate Helicobacter pylori (H. pylori). Efficiency of omeprazole in healing duodenal ulcer has also been observed.


METHODS
Patients suffering from dyspeptic problems and duodenal ulcer but positive H. pylori status (proved with CLO test) have been examined. Patients have been treated during the first seven days with triple therapy (omeprazol 2 x 20 mg, metronidazol 2 x 500 mg and amoksicilin 2 x 1000 mg). Subsequently, the patients were ordered omeprazole 20 mg in the one single morning dose in period of 21 days. Control endoscopy with the view of establishing the rate of healing ulcer and eradicating H. pylori was made four weeks after the beginning of the therapy.


RESULTS
Complete eradication of H. pylori was found with 35/43 (81.4%) patients, and alleviation of ulcer was achieved with 40/43 (93.1%) patients. Not a single patient had any complication after the beginning of treatment with omeprazole. Five patients (11.6%) had increased dyspeptic problems but interruption of the therapy was not required.


CONCLUSIONS
Triple therapy with omeprazole, metronidazol and amoxicilin brings a high rate of eradication H. pylori and healing duodenal ulcer. Therapy is being well tolerated, the pain and dyspeptic problems are being quickly removed.
Gribajcević
M
M
Klinika za gastroenterohepatologiju, Klinicki centar Univerzteta u Sarajevu.
Vanis
N
N
Salaka
U
U
Pasalić
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000254:growth & development*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D010406:Penicillins / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D010406:Penicillins; D008795:Metronidazole; D000658:Amoxicillin; D009853:Omeprazole