Cardiac systolic function before and after hematopoietic stem cell transplantation.
In order to examine the effect of hematopoietic stem cell transplantation (HSCT) on cardiac systolic function, we measured left ventricular ejection fraction (LVEF) by radioventriculography (RVG) before and after the transplantation procedure. One hundred and forty-eight patients were examined, 96 undergoing allogeneic grafting and 52 autologous. Fifty patients had CML, 48 AML, 21 ALL, 18 multiple myeloma and 11 breast cancer. The second RVG examination was performed 22 to 227 days (median 60 days) after HSCT. The mean LVEF value in the whole patient group was 60.2% (range 39-81%) before and 61.1% (35-86%) after transplantation. Patients with CML had significantly higher LVEF before transplantation than patients with acute leukemia (P = 0.007) and multiple myeloma (P = 0.005). No significant changes in mean LVEF between the pre- and post-transplant measurements were seen in any of the diagnostic subgroups or in allogeneic or autologous recipients. None of the 148 patients in the study has shown any signs of clinical heart failure at 2, 5 to 10 years follow-up. Patients who had received anthracyclines in the previous treatment had significantly lower LVEF before transplantation but showed no increased risk of decline in cardiac function. In conclusion, the HSCT procedure does not seem to affect myocardial function 1-7 months after transplantation.
Department of Hematology, Huddinge University Hospital, Sweden.
S
S
Lehmann
B
B
Isberg
P
P
Ljungman
C
C
Paul
D000293:Adolescent; D000328:Adult; D018943:Anthracyclines / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D002066:Busulfan / Q000494:pharmacology; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D015635:Radionuclide Ventriculography; D013318:Stroke Volume / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D013599:Systole / Q000502:physiology*; D019172:Transplantation Conditioning; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000209:etiology*; D014916:Whole-Body Irradiation / Q000009:adverse effects
D018943:Anthracyclines; D002066:Busulfan