Inheritance of pendulum movements in rats.
The stereotyped hyperkinesis referred to as pendulum movements (PM) may be found in up to 50% of the animals in stocks of Wistar rats. The mode of inheritance of predisposition to PM was studied by two methods: 1) a classical Mendelian analysis of hybrids of the strains PM+ and PM- bred from Wistar stock for enhancement and absence of PM, respectively, and 2) a segregation analysis of pedigree data from the archive records of breeding the cataleptic GC strain. The two methods gave the same result: the inheritance of predisposition to PM can be explained by a major gene model with an incomplete penetrance of heterozygous genotype.
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
N N
NN
Barykina
V G
VG
Kolpakov
T A
TA
Alekhina
V F
VF
Chuguy
T I
TI
Axenovich
D000818:Animals; D005260:Female; D006580:Genetic Carrier Screening; D005838:Genotype; D008297:Male; D008957:Models, Genetic; D051381:Rats; D017208:Rats, Wistar; D012641:Selection, Genetic; D013239:Stereotyped Behavior / Q000502:physiology*