AIDS myelopathy is not associated with elevated HIV viral load in cerebrospinal fluid.
The pathogenesis of AIDS-associated myelopathy is unknown. Elevated HIV-1 viral load in CSF has been associated with cognitive impairment. The authors investigated if a similar association exists in patients with myelopathy. The authors evaluated levels of HIV-1 RNA in the CSF of 16 individuals with AIDS myelopathy and in 16 nonmyelopathic HIV-infected control subjects. There was no correlation between levels of HIV-1 RNA and the presence or severity of myelopathy.
Geraci
A
A
Albert Einstein College of Medicine and Beth Israel Medical Center, New York, NY 10003, USA.
Di Rocco
A
A
Liu
M
M
Werner
P
P
Tagliati
M
M
Godbold
J
J
Simpson
D
D
Morgello
S
S
D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid* / Q000821:virology; D000328:Adult; D005260:Female; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000134:cerebrospinal fluid; D012720:Severity of Illness Index; D013118:Spinal Cord Diseases / Q000134:cerebrospinal fluid* / Q000821:virology*; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid; D019562:Viral Load
D012367:RNA, Viral; D014409:Tumor Necrosis Factor-alpha