Non-effect of hexamethonium, a ganglionic blocker, on the response of ileal apolipoprotein A-IV mRNA following a massive small bowel resection in rats.
An intravenous infusion of hexamethonium, a ganglionic blocker, did not affect the increase in the apolipoprotein A-IV mRNA level in the residual ileum following a massive small bowel resection in unrestrained conscious rats. The result suggests that upregulation of the apolipoprotein A-IV gene in the residual ileum is not mediated by a neural pathway, including the nicotinic synapse route.
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan. ksnym@chem.agr.hokudai.ac.jp
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Sonoyama
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Fujiwara
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Kasai
D000818:Animals; D001054:Apolipoproteins A / Q000235:genetics*; D005730:Ganglionic Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D018738:Hexamethonium / Q000008:administration & dosage / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects* / Q000378:metabolism* / Q000601:surgery; D007262:Infusions, Intravenous; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism / Q000601:surgery; D008297:Male; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D001054:Apolipoproteins A; D005730:Ganglionic Blockers; D012333:RNA, Messenger; C022205:apolipoprotein A-IV; D018738:Hexamethonium