Inhibition of mitochondrial succinate oxidation by antipsychotic medication.
Fourteen antipsychotics of 5 different chemical classes were tested for their effects on mitochondrial succinate oxidation. Each of the compounds tested, with the exception of haloperidol, phenothiazine and prochlorperazine, inhibited succinate oxidation. The apparent inhibition constant for phenothiazine derivatives declined with increasing values of the partition coefficient.
Institute of Fundamental Sciences, Massey University, Palmerston North, New Zealand.
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Brown
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Taylor
D000818:Animals; D014150:Antipsychotic Agents / Q000145:classification / Q000494:pharmacology*; D002417:Cattle; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D019802:Succinic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D014150:Antipsychotic Agents; D019802:Succinic Acid