Salicylate induction of phenotypic resistance to quinolones in Serratia marcescens.
The influence of salicylic acid on the permeability and susceptibility of Serratia marcescens to both nalidixic acid and ciprofloxacin was studied, as well as the effect of salicylate on outer membrane proteins and lipopolysaccharide. As salicylic acid concentration increased, ciprofloxacin accumulation decreased with a concomitant, previously observed, reduction in the porin content of the outer membrane. Resistance to ciprofloxacin and nalidixic acid was enhanced when bacteria grew in the presence of salicylic acid.
Microbiology Unit, Campus of Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, E-08907 Spain.
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Berlanga
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Viñas
D000890:Anti-Infective Agents / Q000378:metabolism / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000187:drug effects / Q000378:metabolism; D002939:Ciprofloxacin / Q000378:metabolism / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D008070:Lipopolysaccharides / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000378:metabolism / Q000494:pharmacology; D010641:Phenotype; D012459:Salicylates / Q000494:pharmacology*; D012706:Serratia marcescens / Q000187:drug effects* / Q000378:metabolism
D000890:Anti-Infective Agents; D001425:Bacterial Outer Membrane Proteins; D008070:Lipopolysaccharides; D012459:Salicylates; D009268:Nalidixic Acid; D002939:Ciprofloxacin