Cutaneous herpetic infections complicating burns.
Many people harbor herpes simplex virus, often with a known history of "cold sores". During the relatively immunosuppressed state associated with a serious burn, recrudescence of such infections can occur. We report four adults and two children who developed severe herpetic ulceration, over the face and neck in five patients and in a partial thickness wound in one patient. Herpetic infection was diagnosed by culture and direct immunofluorescence testing and treatment was immediately instituted with systemic and topical Acylovir(R) (Zovirax, Glaxo Wellcome). Ulceration healed under treatment and did not leave visible scarring in any of the patients. Although these infections are rapidly progressive, they respond to prompt treatment with antiviral chemotherapy. Rapidly progressive vesicles and ulceration appearing on the face or in the wounds of burn patients should prompt immediate evaluation for herpetic infection.
Sheridan
R L
RL
Department of Surgery, Division of Burns and Trauma, Massachusetts General Hospital, Boston, MA, USA. sheridan.robert@mgh.harvard.edu
Schulz
J T
JT
Weber
J M
JM
Ryan
C M
CM
Pasternack
M S
MS
Tompkins
R G
RG
D000212:Acyclovir / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D002056:Burns / Q000150:complications*; D005260:Female; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007223:Infant; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment
D000998:Antiviral Agents; D000212:Acyclovir