Susceptibility of juvenile and sub-adult Atlantic halibut (Hippoglossus hippoglossus L.) to infection by Vibrio anguillarum and efficacy of protection induced by vaccination.
Experimental bath challenge of juvenile and sub-adult Atlantic halibut with Vibrio anguillarum induced severe mortalities of 47 and 80%, respectively. However, animals vaccinated with a commercial V. anguillarum vaccine demonstrated excellent protection against the disease (100% RPS). This study also describes the gross pathology and histological changes associated with this infection. A loss of coordination, haemorrhage at the fin base and splenomegaly were frequent findings. Serum agglutinating activity demonstrated a rise following vaccination, the mean log2 titre rising from 3.8 to 8.4. This was associated with a significant rise in antibody-mediated complement killing ability of immune serum when compared to non-immune serum.
FRS Marine Laboratory, Torry, Aberdeen, Scotland, U.K.
I R
IR
Bricknell
T J
TJ
Bowden
D W
DW
Verner-Jeffreys
D W
DW
Bruno
R J
RJ
Shields
A E
AE
Ellis
D000372:Agglutination Tests; D000818:Animals; D017756:Aquaculture; D001428:Bacterial Vaccines; D004198:Disease Susceptibility; D005393:Fish Diseases / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D005412:Flatfishes / Q000276:immunology*; D013154:Spleen / Q000473:pathology; D014611:Vaccination / Q000662:veterinary*; D014735:Vibrio Infections / Q000276:immunology / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*
D001428:Bacterial Vaccines