An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats.
Oxydemeton-methyl, an organophosphate insecticide and acaricide produced decrease in the exploratory behaviour and prolongation of barbitone sodium-induced hypnosis after intermittent aerosol spray inhalational exposure for 1 h in rats compared to the saline control group. Further, CD50 +/- S.E.M. value for pentylenetetrazole (PTZ) and CI50 +/- S.E.M. value for electroshock (i.e. the dose of PTZ and intensity of electroshock producing positive seizure response in 50% of rats) were significantly decreased by acute exposure to oxydemeton-methyl compared to that of saline control group. The study has established the central nervous system depressant effect and proconvulsant potential of oxydemeton-methyl which is widely used by the agricultural workers in the form of field spray.
Department of Pharmacology, Indira Gandhi Medical College, Shimla.
D K
DK
Kansal
A
A
Chakrabarti
D000818:Animals; D001462:Barbital / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D003292:Convulsants; D004597:Electroshock; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D020258:Neurotoxicity Syndromes / Q000523:psychology*; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010433:Pentylenetetrazole; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D003292:Convulsants; D006993:Hypnotics and Sedatives; D007306:Insecticides; D009946:Organothiophosphorus Compounds; D001462:Barbital; C026086:methyl demeton; D010433:Pentylenetetrazole