Efficient synthesis of 8-oxo-dGTP: a mutagenic nucleotide.
An efficient synthesis of mutagenic and oxidative DNA damage product, 8-oxo-dGTP (4) has been achieved in high yield, along with a serendipitous generation of 8-dimsyl-dG (2). In combination with dPTP (5), 8-oxo-dGTP (4) can be formulated into a kit for investigating DNA random mutagenesis.
Amersham Pharmacia Biotech, Piscataway, NJ 08855, USA.
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Nampalli
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Kumar
D003848:Deoxyguanine Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009153:Mutagens / Q000138:chemical synthesis* / Q000737:chemistry
D003848:Deoxyguanine Nucleotides; D009153:Mutagens; C078206:8-oxodeoxyguanosine triphosphate