Brachial plexopathy associated with diffuse edematous scleroderma.
Peripheral nervous system (PNS) involvement is rare in systemic sclerosis (SSc), usually restricted to peripheral nerve entrapment. To our knowledge, only one case of scleroderma with brachial plexus involvement has been reported previously. We report here on a 61-year-old woman with past history of limited cutaneous SSc who developed motor deficiency in the left arm concomitant with diffuse edematous scleroderma without evidence for trauma or compression of the brachial plexus. After six months intravenous pulse cyclophosphamide therapy, dramatic improvement of skin and neurological involvement was observed.
Mouthon
L
L
Department of Internal Medicine, Hôpital Avicenne and Paris-Nord University, 125, route de Stalingrad, 93000 Bobigny, France. luc.mouthon@avc.ap-hop-paris.fr
Halimi
C
C
Dussaule Md
J C
JC
Cayre-Castel Md
M
M
Guillevin
L
L
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D020516:Brachial Plexus Neuropathies / Q000209:etiology* / Q000503:physiopathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D009048:Motor Skills; D011241:Prednisone / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000150:complications*; D012595:Scleroderma, Systemic / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011241:Prednisone