Adverse pregnancy outcome following post-chorionic villus sampling amniocentesis compared to chorionic villus sampling.
OBJECTIVE
To assess the adverse pregnancy outcome of post-chorionic villus sampling (CVS) amniocentesis and chorionic villus sampling.


METHODS
Adverse pregnancy outcomes of 32 post-CVS amniocentesis cases and 264 CVS only cases were compared. The base-line characteristics were comparable in the 2 groups.


RESULTS
One (3.1%) chromosomal abnormality was detected in the post-CVS amniocentesis group, compared to 5 (1.8%) in the CVS only group (p > 0.05). The fetal loss rate (spontaneous abortions and stillbirths) among continuing pregnancies was 3.2% in the post-CVS amniocentesis group and 3.5% in the CVS only group (p > 0.05). No statistically significant difference was found in the incidence of neonatal death, preterm delivery, fetal growth restriction, or congenital anomalies between the 2 groups.


CONCLUSIONS
Adverse pregnancy outcome occurred at a similar frequency in the post-CVS amniocentesis group as in the CVS only group. Therefore, a subsequent amniocentesis after CVS can be considered as a safe procedure that does not introduce any additional adverse pregnancy outcome compared to that of CVS only.
Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
S K
SK
Kim
D J
DJ
Cho
J W
JW
Kim
J E
JE
Chung
Y H
YH
Yang
D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects*; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D002869:Chromosome Aberrations; D005260:Female; D005313:Fetal Death; D005317:Fetal Growth Retardation; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011256:Pregnancy Outcome