Plasma, urine and skin pharmacokinetics of cefepime in burns patients.
We studied the pharmacokinetics of cefepime (2 g bd) in six burns patients. Blood, urine and skin samples were collected to measure cefepime concentrations. A two-compartment model was fitted to the data. At day 1, t(1/2beta) was 2.45 +/- 0.56 h, V(ss) 0.36 +/- 0.1 L/kg, total clearance 152 +/- 25.2 mL/min, and AUC 217 +/- 34 mg*h/L. There was no statistical difference between day 1 and day 3 for any of the pharmacokinetic parameters. We demonstrated good penetration of cefepime in skin. These results show that it is not necessary to change the standard dosage of cefepime in burns patients.
Laboratory of Pharmacokinetics, Hôpital de la Timone and Université de la Méditerranée, and Department of Anesthesiology and Regional Burn Center, Hôpital de la Conception, Marseille, France.
E
E
Sampol
A
A
Jacquet
M
M
Viggiano
V
V
Bernini
J C
JC
Manelli
B
B
Lacarelle
A
A
Durand
D000328:Adult; D019540:Area Under Curve; D002056:Burns / Q000378:metabolism*; D000077723:Cefepime; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
D002511:Cephalosporins; D000077723:Cefepime