Preparation and evaluation of samarium (III) phosphate [(153)Sm] colloid (SMPC) for possible therapeutic use.
A simple method of preparation of a new therapeutic colloid, samarium(III) phosphate-(153)Sm (SMPC), is reported involving the reaction of carrier-added (153)SmCl(3) with phosphoric acid. Recovery of the colloid was accomplished by dialysis leading to purification and a radiochemical (RC) yield of more than 90%. The RC purity of purified colloid formulated in isotonic phosphate buffer was more than 99% as assessed by paper chromatography. The product retained its RC purity throughout the period of stability study of 7 days. Complete retention of radioactivity instilled in the rabbit knee joint was observed over the study period of 6 days, with radioactivity in the blood being indistinguishable from the natural background activity. Ninety-six percent of colloidal particles were in the size range of 0.3-2 microm. The promising results demonstrated warrant further studies on SMPC for assessing the suitability for therapy.
Radiopharmaceuticals Programme, Board of Radiation and Isotope Technology (BRIT), Bhabha Atomic Research Center (BARC) Vashi Complex, Navi Mumbai, India.
G
G
Prabhakar
S H
SH
Joshi
D K
DK
Ranganatha
S
S
Umamaheswari
M
M
Ananthakrishnan
N
N
Ramamoorthy
D000818:Animals; D003102:Colloids; D011817:Rabbits; D011868:Radioisotopes / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012493:Samarium / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution
D003102:Colloids; D011868:Radioisotopes; D012493:Samarium