No evidence for association of alpha 1a adrenoceptor gene polymorphism and clozapine-induced urinary incontinence.
Clozapine is an effective atypical antipsychotic that has high affinity for many neurotransmitter receptors. Among the adverse effects of clozapine, urinary incontinence is commonly found and is suggested to be caused by alpha-adrenergic blockade. We tested the hypothesis that clozapine-induced urinary incontinence is related to a genetic variant of the alpha(1a)-adrenoceptor. We also tested whether the alpha(1a)-receptor gene confers susceptibility to schizophrenic disorders. Our result indicated that the alpha(1a)-adrenoceptor gene polymorphism investigated plays no major role in the pathogenesis of schizophrenia or in clozapine-induced urinary incontinence. Considering the superior effects of clozapine and its potent adrenergic antagonistic effects, it is of interest to investigate the association between this polymorphism and the treatment response.
Hsu
J W
JW
Section of Psychiatry, Yu-Li Veterans Hospital, National Yang-Ming University, Veterans General Hospital-Taipei, Taiwan, ROC.
Wang
Y C
YC
Lin
C C
CC
Bai
Y M
YM
Chen
J Y
JY
Chiu
H J
HJ
Tsai
S J
SJ
Hong
C J
CJ
D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D011569:Psychiatric Status Rating Scales; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy / Q000235:genetics; D012565:Schizophrenic Psychology; D014549:Urinary Incontinence / Q000139:chemically induced* / Q000235:genetics*
C547713:ADRA1A protein, human; D014150:Antipsychotic Agents; D018340:Receptors, Adrenergic, alpha-1; D003024:Clozapine