Primary anaplastic large cell lymphoma of the adrenal gland.
Primary adrenal lymphomas are rare. Most reported cases are of B-cell phenotype and follow an aggressive clinical course. We report a case of primary anaplastic large cell, CD30+ adrenal lymphoma developing in a 62-year-old woman. The patient presented with fatigue and vague right upper quadrant pressure. Computed tomography revealed bilateral adrenal masses. A right adrenalectomy was performed. Histologic evaluation showed islands of large atypical cells surrounded by eosinophilic acellular material. The tumor cells stained positive for CD45, CD45RO, CD43, and CD30. Epstein-Barr virus genome was identified in tumor cells using in situ hybridization. The patient was treated with chemotherapy and a 23-month follow-up examination showed no change in the size of the opposite adrenal gland and no other evidence of lymphoma.
Frankel
W L
WL
Department of Pathology, The Ohio State University Medical Center and Arthur G. James Cancer Hospital and Research Institute, Columbus, USA.
Shapiro
P
P
Weidner
N
N
D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D000315:Adrenalectomy; D015703:Antigens, CD; D003131:Combined Modality Therapy; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D051917:Leukosialin; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008875:Middle Aged; D012795:Sialoglycoproteins / Q000032:analysis
D015703:Antigens, CD; D017730:Ki-1 Antigen; D051917:Leukosialin; C465014:SPN protein, human; D012795:Sialoglycoproteins; D017493:Leukocyte Common Antigens