[Changes in the vascular wall in a combination of hypercholesterolemia and posttraumatic regeneration of the endothelium].
Proceeding from our notions about proatherogenic properties of hypercholesterinemia and capability of injurious effects on the vascular wall to stimulate the process, sequelae were studied of a combined effect of the above factors on the endothelial monolayer of the aorta in an animal experiment (rabbits, n = 17). Used in the study were AgNO3 impregnation, electron microscopy, histochemistry, and morphometry. It has been ascertained that association of chronic hypercholesterinemia with local mechanical damage to the vascular endothelium tends to change its morphofunctional properties to a greater degree than in differentiated action of each of them promoting significantly the development of atherosclerosis in differentiated action of each of them.
Gavrish
A S
AS
Lisovets
M A
MA
Blagodarova
E V
EV
D000222:Adaptation, Physiological; D000818:Animals; D001011:Aorta / Q000293:injuries* / Q000502:physiology / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D004036:Diet, Atherogenic; D004730:Endothelium, Vascular / Q000293:injuries* / Q000502:physiology / Q000648:ultrastructure; D006651:Histocytochemistry; D006937:Hypercholesterolemia / Q000473:pathology / Q000503:physiopathology*; D008854:Microscopy, Electron; D011817:Rabbits; D012038:Regeneration / Q000502:physiology*