M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein.
We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) protein whose gene was previously localized to chromosome 1q42 [Allikmets et al. (1995) Mamm. Genome 6, 111-117]. The gene transcript is expressed in all human tissues examined, with the highest levels in bone marrow. A non-expressed pseudogene also exists at chromosome 15q13-14. The new protein, which is most similar to the mitochondrial (M)-ABC1 protein, was also localized to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-ABC2 was shown to contain a mitochondrial-targeting signal sequence.
BC Cancer Research Centre, British Columbia Cancer Agency, University of British Columbia, 601 West 10th Avenue, V5Z 1L3, Vancouver, BC, Canada.
F
F
Zhang
D L
DL
Hogue
L
L
Liu
C L
CL
Fisher
D
D
Hui
S
S
Childs
V
V
Ling
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D002460:Cell Line; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D003001:Cloning, Molecular; D020869:Gene Expression Profiling; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007425:Intracellular Membranes / Q000737:chemistry; D008928:Mitochondria / Q000737:chemistry*; D008969:Molecular Sequence Data; D010802:Phylogeny; D020161:Physical Chromosome Mapping; D021382:Protein Sorting Signals / Q000235:genetics; D011544:Pseudogenes / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D016415:Sequence Alignment; D014162:Transfection
C412459:ABCB10 protein, human; D018528:ATP-Binding Cassette Transporters; D021382:Protein Sorting Signals; D012333:RNA, Messenger