Hexachlorophene-induced brain edema in rat observed by proton magnetic resonance.
Rat brain was examined with 4.7 T proton magnetic resonance (MR). On administering hexachlorophene (HCP) 30 mg/kg/day for 5 days, myelin-rich structures stood out in T2-weighted images. Apparent diffusion coefficient (ADC) was markedly suppressed in all regions examined except for cerebral cortex. Seven days after terminating the exposure to HCP, without enhancement in T2-weighted images, ADC was still decreased in corpus callosum, optic nerve and trigeminal nerve. Rat administered with HCP and followed with high magnetic field proton MR seems to provide a good model for cytotoxic brain edema, and it may also be useful to visualize heavily myelinated structures.
Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Japan. yosimasa@med.uoeh-u.ac.jp
Y
Y
Kinoshita
H
H
Matsumura
H
H
Igisu
A
A
Yokota
D000818:Animals; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000139:chemically induced* / Q000175:diagnosis*; D003337:Corpus Callosum / Q000473:pathology; D004058:Diffusion; D006582:Hexachlorophene; D008279:Magnetic Resonance Imaging; D008297:Male; D009900:Optic Nerve / Q000473:pathology; D011522:Protons; D051381:Rats; D014276:Trigeminal Nerve / Q000473:pathology
D011522:Protons; D006582:Hexachlorophene