Cisapride provides symptomatic relief in functional dyspepsia associated with gastric myoelectrical abnormality.
OBJECTIVE
We evaluated the effects of cisapride (10 mg t.d.s. and 20 mg b.d.) on gastrointestinal symptoms and gastric myoelectrical activity in patients with functional dyspepsia. Myoelectrical activity was measured by electrogastrography.


METHODS
Patients with functional dyspepsia, defined as discomfort in the epigastrium, a negative endoscopy, and clinical symptoms of dyspepsia, were enrolled. A total of 38 patients participated in the study (23 female; 15 male; 24-72 years of age). Screening electrogastrography identified those with a normal electrogastrogram (14 subjects) and those with an abnormal electrogastrogram (24 patients). Patients were randomly assigned to 2 weeks of placebo or 2 weeks of cisapride (10 mg t.d.s.); both groups then received 2 weeks of cisapride (20 mg b.d.). Electrogastrograms were repeated at the end of each 2-week treatment period.


RESULTS
Cisapride 10 mg t.d.s. significantly improved symptoms in all patients. An additional 2 weeks of treatment with cisapride 20 mg b.d. led to continued improvement in symptoms in all patients, with significant improvement in the group with abnormal baseline electrogastrograms. Cisapride significantly improved postprandial bloating and discomfort in patients with abnormal baseline electrogastrograms. Cisapride also significantly improved postprandial gastric myoelectrical activity as measured by electrogastrography in patients with abnormal baseline electrogastrograms.


CONCLUSIONS
Cisapride provides symptomatic relief and improves gastric myoelectrical abnormalities in patients with functional dyspepsia.
Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX 77555-0764, USA. jiande.chen@utmb.edu
J D
JD
Chen
M Y
MY
Ke
X M
XM
Lin
Z
Z
Wang
M
M
Zhang
D000328:Adult; D000368:Aged; D020117:Cisapride / Q000008:administration & dosage / Q000494:pharmacology*; D004415:Dyspepsia / Q000188:drug therapy* / Q000473:pathology; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D019518:Postprandial Period; D013270:Stomach / Q000502:physiology*; D016896:Treatment Outcome
D005765:Gastrointestinal Agents; D020117:Cisapride