Vasomotor hyporeactivity in the anterior cerebral artery during motor activation in Huntington's disease patients.
This experiment used functional transcranial Doppler ultrasonography to demonstrate that blood flow velocity in the anterior cerebral artery is hyporeactive in Huntington's disease (HD) patients during maze testing (P<0.05). These vascular changes are due to tracing, as opposed to problem solving, components of the maze task. Using logistic regression, the reactivity of the ACA during activation is able to categorize patients as being either gene negative, or positive, for HD (P=0.0007). The possible role that nitric oxide/peroxynitrite may play in this phenomena is discussed.
University of Connecticut Medical School, Mail Code 2103, Department of Psychiatry, Program in Neuroscience, Huntington's Disease Program, 263 Farmington Avenue, Farmington, CT 06030-2103, USA. deckel@psychiatry.uchc.edu
A W
AW
Deckel
J D
JD
Duffy
D000328:Adult; D020771:Anterior Cerebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D007839:Functional Laterality; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016015:Logistic Models; D018782:Maze Learning; D009043:Motor Activity; D012720:Severity of Illness Index; D017585:Ultrasonography, Doppler, Transcranial; D014666:Vasomotor System / Q000000981:diagnostic imaging / Q000503:physiopathology*