Solid phase synthesis of [18F]labelled peptides for positron emission tomography.
A strategy for the solid phase synthesis of [18F]labelled peptides has been developed. The peptides were prepared on solid support and acylated with 4-[18F]fluorobenzoic acid using HATU within 3 min and the labelled peptide was released from the solid support within 7 min. The [18F]labelled peptides were produced in good purity with a specific activity of 20-25 GBq/micromol.
Department of Pharmacy, Kings College London, UK.
J L
JL
Sutcliffe-Goulden
M J
MJ
O'Doherty
S S
SS
Bansal
D000215:Acylation; D000595:Amino Acid Sequence; D001565:Benzoates; D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D014055:Tomography, Emission-Computed
D001565:Benzoates; D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D009842:Oligopeptides; C022893:4-fluorobenzoic acid