Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology.
Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.
Wright
W E
WE
Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA.
Shay
J W
JW
D000818:Animals; D002455:Cell Division; D016922:Cellular Senescence; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000209:etiology* / Q000517:prevention & control*; D013045:Species Specificity; D019098:Telomerase / Q000235:genetics / Q000502:physiology; D016615:Telomere / Q000502:physiology*
D019098:Telomerase