Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP.
Saarelainen
T
T
A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland.
Pussinen
R
R
Koponen
E
E
Alhonen
L
L
Wong
G
G
Sirviö
J
J
Castrén
E
E
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000503:physiopathology*; D051379:Mice; D008822:Mice, Transgenic; D020813:Receptor, trkB / Q000235:genetics* / Q000378:metabolism; D013028:Space Perception / Q000502:physiology*
D019208:Brain-Derived Neurotrophic Factor; D020813:Receptor, trkB