[Clinical evaluation of granisetron hydrochloride for nausea and vomiting induced by oral anticancer drugs].
We investigated the antiemetic effect, safety and usefulness of granisetron hydrochloride tablets on nausea and vomiting induced by oral anticancer drugs used in chemotherapy for gastric cancer and colorectal cancer. In the present trial, oral administration of granisetron hydrochloride was performed during 5 days after nausea or vomiting. 1) Clinically, the effective rate of granisetron hydrochloride (the percentage of cases in which the drug was assessed as "Remarkably effective" or "Effective") was more than 75% on each day of administration. There were no adverse events or abnormal laboratory tests. 2) In terms of usefulness, granisetron hydrochloride was rated "Extremely useful" or "Useful" in 17 out of 23 cases (78.2%). The above results have shown that granisetron hydrochloride tablets, administrated orally once daily at a dose of 2 mg, have an excellent antiemetic effect, and that this is a safe and useful drug.
Dept. of Surgery II, Yokohama City University.
S
S
Togo
C
C
Kunisaki
Y
Y
Moriwaki
S
S
Yamaguchi
Y
Y
Ichikawa
S
S
Oki
H
H
Shimada
M
M
Takahashi
H
H
Ike
T
T
Fukushima
Y
Y
Obi
A
A
Kubo
T
T
Takahashi
H
H
Hosoi
S
S
Fukazawa
T
T
Suda
Y
Y
Yamazaki
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D013607:Tablets; D014840:Vomiting, Anticipatory / Q000188:drug therapy* / Q000209:etiology
D000932:Antiemetics; D000970:Antineoplastic Agents; D017829:Granisetron; D013607:Tablets