[Clinical study of childhood acute myelogenous leukemia].
OBJECTIVE
To investigate the clinical characteristics, treatment responsiveness and prognostic factors of childhood acute myelogenous leukemia.


METHODS
Two hundred and seventy-four children with acute myelogenous leukemia diagnosed between 1978 and 1995 were retrospectively analyzed.


CONCLUSIONS
Male:female is 1.6:1. The median age was 7.25 years. M2 and M3 were the commonest subtypes(80%). Twenty cases were hyperleukocytosis and 24 with extramedullary involvement. Thirty two percent of the patients was Auer rods positive. Two hundred and forty-four patients received combination chemotherapy. Complete remission (CR) rates varied from 55.88% to 92.31%. Intensive chemotherapy(including DA, DA + Vm26 or Vp16) was the cornerstone for high CR rate. Other factors influencing CR rate were initial WBC count and hepatosplenomegaly.
Beijing Childrens Hospital.
X
X
Zhao
Y
Y
Hu
Y
Y
Zang
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003630:Daunorubicin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies
D004317:Doxorubicin; D003630:Daunorubicin