The influence of plasticizer molecular weight on spreading droplet size of HPMC aqueous solutions using an indirect method.
Film coating is a complex process that involves many factors. To ensure spreading and/or film capability, plasticizers are added. The role of different molecular weights of polyethylene glycol on the behavior of hydroxypropylmethylcellulose (HPMC) with different grades was determined and compared with values for the film without the plasticizer using a real method for spreading. The droplet size, distribution, and shape were analyzed as the criterion. The results show that the polymer grades and plasticizer types are important in droplet size formation.
Mazandaran University of Medical Sciences, School of Pharmacy, Sari, Iran.
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Orafai
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Shojaei
D020099:Coated Materials, Biocompatible / Q000737:chemistry; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D008970:Molecular Weight; D010968:Plasticizers / Q000737:chemistry*; D015203:Reproducibility of Results; D012996:Solutions; D014783:Viscosity; D014867:Water / Q000737:chemistry
D020099:Coated Materials, Biocompatible; D010968:Plasticizers; D012996:Solutions; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose