Exercise and oxidative stress methodology: a critique.
Historically, exercise physiologists' interest in oxygen has primarily centered on the problem of oxygen consumption. However, the interest of the general scientific community in oxygen-centered radicals has raised awareness of the oxygen paradox and has motivated investigators to question whether exercise-stimulated "overconsumption" of oxygen might induce an oxidative stress and pose some risk to biological systems. In recent years, a considerable amount of research has demonstrated that radicals are capable of damaging a vast array of biological targets. Unfortunately, the work related to oxidative stress and antioxidants subsequent to exercise has been narrow in scope. This paper provides a brief review of the shortcomings of the present state of knowledge in this discipline and outlines topics requiring attention.
Jenkins
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Biology Department, Ithaca College, Ithaca, NY 14850, USA. jenkins@ithaca.edu
D000368:Aged; D002648:Child; D015444:Exercise / Q000502:physiology*; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology*; D010420:Pentanes / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000502:physiology*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D010420:Pentanes; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; C033353:pentane; D005978:Glutathione