Neuroprotective activity of tiagabine in a focal embolic model of cerebral ischemia.
Gamma aminobutyric acid (GABA) agonists have been shown to have neuroprotective effects when used after focal or global cerebral ischemia. In this study, we evaluated the neuroprotective effects of a GABA re-uptake inhibitory agent, tiagabine, on focal ischemic brain injury in an embolic model in rats. Tiagabine, injected at 1 h after embolization, significantly reduced brain infarction volume, measured with 2,3,5-triphenyltetrazolium chloride (TTC) histological assay. There were varying degrees of neuroprotective effect exhibited in the other experimental groups however this did not reach significance. These results suggest that tiagabine is neuroprotective when administrated at an early period after the ischemic brain injury.
The Department of Medicine, Division of Neurology, 2E3.13 WMHSC, University of Alberta Hospital, T6G 2B7, Edmonton, Canada.
W
W
Chen Xu
Y
Y
Yi
L
L
Qiu
A
A
Shuaib
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology*; D002544:Cerebral Infarction / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D020766:Intracranial Embolism / Q000150:complications*; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D014179:Neurotransmitter Uptake Inhibitors / Q000627:therapeutic use*; D009557:Nipecotic Acids / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D000078308:Tiagabine
D018696:Neuroprotective Agents; D014179:Neurotransmitter Uptake Inhibitors; D009557:Nipecotic Acids; D000078308:Tiagabine