[P16 expression in lung cancer and its significance].
OBJECTIVE
To study the relationship of suppressor gene p16 and lung cancer for prognosis evaluation.


METHODS
Immunohistochemical method was used to detect and analyse the expression of P16 protein of CDKN2 suppressor gene of 76 cases in formalin-fixed, paraffin-embedded tissue specimens of human lung cancer.


RESULTS
P16 positive rate was 45%: 52% for 23 of 44 cases of squamous carcinoma and 29% for 7 of 24 cases of adenocarcinoma. Differentiation degree and prognosis of lung cancer were associated significantly with P16 expression. P16 expression was somewhat related to clinical stage.


CONCLUSIONS
P16 gene plays a key role in the prognosis of patients with lung cancer.
Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing.
Y
Y
Guo
J
J
Guan
B
B
Ge
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis*; D005260:Female; D015870:Gene Expression; D019942:Genes, p16; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D019941:Cyclin-Dependent Kinase Inhibitor p16