T-cell regulation of peripheral tolerance and immunity: the potential role for Notch signalling.
Recognition of antigen by T cells in the periphery may lead either to the generation of productive immunity or the induction of tolerance. These two functional outcomes are a consequence of distinct pathways of T-cell differentiation. T cells are selected to become regulatory cells and their function is to maintain homeostasis with the immune system. In this review we discuss the cell-fate decisions that T cells might make allowing them to promote immunity or induce tolerance in the context of the role that Notch signalling may play in this process.
Immunobiology Group, MRC Centre for Inflammation Research and the Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, UK.
G F
GF
Hoyne
M J
MJ
Dallman
J R
JR
Lamb
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D051880:Receptors, Notch; D015398:Signal Transduction / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D008565:Membrane Proteins; D051880:Receptors, Notch