Steroid regulation of postembryonic development and reproduction in Drosophila.
Ecdysteroids trigger major developmental transitions in Drosophila, including larval molts and metamorphosis. Recent genetic studies strongly support a role for the Ecdysteroid receptor (EcR)/Ultraspiracle (USP) heterodimer as an ecdysteroid receptor at the onset of metamorphosis, functioning as both a transcriptional activator and repressor in vivo. Genetic analysis also indicates that USP, like its vertebrate homolog retinoid X receptor (RXR), might be involved in regulatory pathways independently of EcR. The ecdysteroid hierarchy was also shown recently to regulate Drosophila oogenesis and reproduction.
Kozlova
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Howard Hughes Medical Institute, 15 N 2030 E Rm 5100, University of Utah, UT 84112-5331, USA. kozlova@howard.genetics.utah.edu
Thummel
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D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D047108:Embryonic Development; D012098:Reproduction / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics; D013256:Steroids / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics
D013256:Steroids