Erythromycin improves gastric emptying in critically ill patients intolerant of nasogastric feeding.
OBJECTIVE
To evaluate the effect of intravenous erythromycin on gastric emptying and the success of enteral feeding in mechanically ventilated, critically ill patients with large volume gastric aspirates.


METHODS
Prospective, double-blind, randomized, and placebo-controlled trial.


METHODS
General intensive care unit in a university hospital.


METHODS
Twenty critically ill, mechanically ventilated patients intolerant of nasogastric feeding (indicated by a residual gastric volume of > or =250 mL during feed administration at > or =40 mL/hr).


METHODS
After a gastric aspirate of > or =250 mL, which was discarded, the enteral feeding was continued at the previous rate for 3 hrs. Intravenous erythromycin (200 mg) or placebo was then administered over 20 mins. The residual gastric contents were again aspirated and the volume was recorded 1 hr after the infusion began.


RESULTS
Gastric emptying was calculated as volume of feed infused into the stomach over 4 hrs minus the residual volume aspirated. Mean gastric emptying was 139+/-37 (+/-SEM) mL after erythromycin and -2+/-46 mL after placebo (p = .027). Nasogastric feeding was successful in nine of ten patients treated with erythromycin and five of ten who received placebo 1 hr after infusion (chi-square p = .05).


CONCLUSIONS
In critically ill patients who have large volumes of gastric aspirates indicating a failure to tolerate nasogastric feeding, a single small dose of intravenous erythromycin allows continuation of feed in the short term.
Royal Adelaide Hospital, SA, Australia.
M J
MJ
Chapman
R J
RJ
Fraser
M T
MT
Kluger
M D
MD
Buist
D J
DJ
De Nichilo
D018806:APACHE; D003422:Critical Care; D004311:Double-Blind Method; D004750:Enteral Nutrition; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D007441:Intubation, Gastrointestinal / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial
D005765:Gastrointestinal Agents; D004917:Erythromycin