Novel functions of interferon-induced proteins.
Interferons are important cytokines which regulate antiviral, cell growth, immune modulatory and anti-tumor functions. These pleiotropic effects of interferons are brought about by a large number of cellular proteins, the interferon-inducible proteins. Investigation of the biochemical and cellular activities of some of these proteins have revealed new pathways of regulation of cellular RNA and protein metabolism, growth and differentiation, apoptosis and signal transduction. In this article we discuss recent findings on the novel activities of a selected number of interferon-induced proteins.
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Department of Molecular Biology/NC20, The Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA.
D015088:2',5'-Oligoadenylate Synthetase / Q000502:physiology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002352:Carrier Proteins / Q000502:physiology*; D002454:Cell Differentiation; D002460:Cell Line / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D047908:Intracellular Signaling Peptides and Proteins; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D015398:Signal Transduction; D000071857:Tumor Suppressor p53-Binding Protein 1; D019892:eIF-2 Kinase / Q000502:physiology*
D000998:Antiviral Agents; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; C498301:TP53BP1 protein, human; D000071857:Tumor Suppressor p53-Binding Protein 1; D007372:Interferons; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D019892:eIF-2 Kinase; D015088:2',5'-Oligoadenylate Synthetase