Obesity. Enzyme blocker prompts mice to shed weight.
A multidisciplinary team may have discovered an important new weapon in the battle of the bulge. On page 2379 of this issue, the team reports that a molecule that is needed for fat synthesis in the body may play a key role in appetite signaling in the brain. Moreover, the investigators produced a synthetic inhibitor of this molecule that spurred a dramatic drop in appetite and weight in mice.
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D000818:Animals; D001066:Appetite / Q000187:drug effects; D001067:Appetite Depressants / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005215:Fasting; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008316:Malonyl Coenzyme A / Q000378:metabolism; D051379:Mice; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects*
D001067:Appetite Depressants; D004791:Enzyme Inhibitors; D009478:Neuropeptide Y; D012333:RNA, Messenger; D008316:Malonyl Coenzyme A; D064429:Fatty Acid Synthases