3-Nitropropionic acid and similar nitrotoxins.
3-Nitropropionic acid as well as 3-nitro-1-propanol and its beta-D-glucopyranoside (miserotoxin) are the plant and fungal toxins reported to interrupt mitochondrial electron transport resulting in cellular energy deficit. These nitrotoxins induce neurological degeneration in ruminants and humans. 3-Nitropropionic acid-intoxicated rats serve as the animal model for Huntington's disease.
Patocka
J
J
Department of Toxicology, Purkynĕ Military Medical Academy, Hradec Králové. patocka@pmfhk.cz
Bielavský
J
J
Cabal
J
J
Fusek
J
J
D000818:Animals; D005960:Glucosides / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D009183:Mycotoxins / Q000737:chemistry; D009498:Neurotoxins / Q000737:chemistry / Q000633:toxicity; D009574:Nitro Compounds; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity; D010947:Plants, Toxic; D020005:Propanols / Q000737:chemistry / Q000633:toxicity; D011422:Propionates / Q000737:chemistry / Q000633:toxicity
D005960:Glucosides; D009183:Mycotoxins; D009498:Neurotoxins; D009574:Nitro Compounds; D010936:Plant Extracts; D020005:Propanols; D011422:Propionates; C020776:miserotoxin; C024522:3-nitro-1-propanol; C015392:3-nitropropionic acid