[Effect of the di mutation (non-sugar diabetes) on properties of kidney proteins in rats].
Renal proteins were studied in Brattleboro rats of the didi genotype and in Wistar and Sprague-Dawley rats with normal alleles +2 of this loci. In animals of the +2 genotype maintained under conditions of water deprivation, the content of 120 kDa protein increased significantly in inner medulla of the kidney over 3 days. No changes in the amount of this protein were observed in rats of the didi genotype under the same conditions. We suggest that the congenital inability of didi mutants to synthesize vasopressin accounts for the distinctions observed in the reactions of rats with different genotypes.
Khegaĭ
I I
II
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia. khegay@bionet.nsc.ru
D000818:Animals; D003919:Diabetes Insipidus / Q000235:genetics*; D007668:Kidney / Q000378:metabolism*; D009154:Mutation; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D051381:Rats; D011910:Rats, Brattleboro; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D014667:Vasopressins / Q000096:biosynthesis
D011506:Proteins; D014667:Vasopressins