Studies on the synthesis of N(G)-nitro-L-arginine derivatives and their effects on septic shock.
(HCl x N(G)-NO2-Arg)2Lys-OCH3, (HCl x N(G)-NO2-Arg)2Lys-OH, [(HCl x N(G)-NO2-Arg)2Lys]2Lys-OCH3, and [(HCl x N(G)-NO2-Arg)2Lys]2Lys-OH were synthesized by use of a solution method. Their effect on septic shock was studied in vivo. The results indicate that increasing the number of N(G)-NO2-Arg residues in a molecule may be useful to improve the response to septic shock.
College of Pharmaceutical Sciences, Beijing Medical University, P. R. China.
Z
Z
Ming
W
W
Chao
G
G
Mingdi
P
P
Shiqu
Y
Y
Junke
Z
Z
Kexiang
W
W
Saizhu
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use*; D019335:Nitroarginine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012772:Shock, Septic / Q000188:drug therapy*
D004791:Enzyme Inhibitors; D019335:Nitroarginine