Effects of somatostatin analogues and vitamin C on bacterial translocation in an experimental intestinal obstruction model of rats.
The passage of viable endogenous bacteria and their products across the intact intestinal mucosal barrier, disseminating to the mesenteric lymph nodes, peritoneal cavity, spleen, liver, and circulation, is defined as bacterial translocation. Intestinal obstruction induces bacterial translocation due to mucosal disruption, motility dysfunction, and increased intestinal volume, leading to bacterial overgrowth. In a rat model of intestinal obstruction, the effects of both high-dose vitamin C (350 microg/kg), an antioxidant agent known to have a cytoprotective effect in ischemia-reperfusion injury, and somatostatin (20 microg/kg), a gastrointestinal antisecretory agent, in preventing bacterial translocation were studied. Both intestinal and liver samples from the rats was observed, and it was found that the rate of bacterial translocation was 100% in the control group, and only 43% for the rats who were given intraperitoneal vitamin C and somatostatin. The difference was statistically significant. In conclusion, we are convinced that vitamin C and somatostatin analogues may have protective effects against bacterial translocation in mechanical bowel obstruction.
Department of General Surgery, Faculty of Medicine, Ege University, Bornova Izmir, Turkey.
M
M
Akyildiz
S
S
Ersin
E
E
Oymaci
M
M
Dayangaç
M
M
Kapkac
M
M
Alkanat
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D018988:Bacterial Translocation / Q000187:drug effects*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006728:Hormones / Q000494:pharmacology*; D007415:Intestinal Obstruction / Q000188:drug therapy / Q000382:microbiology* / Q000517:prevention & control; D008099:Liver / Q000382:microbiology; D008198:Lymph Nodes / Q000382:microbiology; D008640:Mesenteric Lymphadenitis / Q000188:drug therapy / Q000378:metabolism; D015282:Octreotide / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D006728:Hormones; D001205:Ascorbic Acid; D015282:Octreotide