[Hepatitis B virus infection and aflatoxin exposure in the development of primary liver cancer].
OBJECTIVE
To investigate the role of hepatitis B Virus (HBV) infection and aflatoxin (AF) exposure in the development of primary liver cancer (PLC).


METHODS
A 10-year prospective case-control study was carried out in 737 HBsAg carriers and 699 HBsAg negative cases, and the aflatoxin B1 albumin adducts (AFB1-Alb) were detected in the serum of the cohort including 30 HBsAg postive cases and 150 control individuals according to the case-control study model (ratio 1:5) at random in the high prevalance area of PLC.


RESULTS
The average year-incidence rate was significantly higher in the HBsAg postive group (824.13/100,000) than in the control group (70.97/100,000, RR = 11.61). There was no significant difference in the incidence rate of other tumors between the two groups (P > 0.05). The serum positive rate of AFB1-Alb was significantly higher in the PLC group (76.67%) than in the control group (48.67%, OR = 3.47), and the serum concentration of AFB1-Alb was also significantly higher in the PLC group than in the control group (P < 0.01).


CONCLUSIONS
HBV infection and AF exposure are important etiological factors in the development of PLC and both result in carcinogenic synergy.
Lu
P
P
Qidong Liver Cancer Institute, Jiangsu.
Kuang
S
S
Wang
J
J
D000328:Adult; D016604:Aflatoxin B1 / Q000009:adverse effects / Q000097:blood*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D011897:Random Allocation
D016604:Aflatoxin B1