[CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility].
OBJECTIVE
To evaluate the relationship between CYP2D6 and GSTM1 genetic polymorphism and lung cancer susceptibility among Cantonese in China.


METHODS
In a case-control study, PCR was used to identify CYP2D6 and GSTM1 genotypes and restriction enzyme BstNI was used to identify a specific point mutation of CYP2D6.


RESULTS
Between lung cancer patient group and normal control group CYP2D6 genetic polymorphism did not show frequency distribution differences but that of GSTM1 did (58.7% n = 46, 35.7%, n = 70, P < 0.05) OR = 2.56(1.11-2.44).


CONCLUSIONS
There is no association between CYP2D6 G-A mutation and lung cancer susceptibility, while individuals with GSTM1 -/- genotype are susceptible to lung cancer.
Department of Hygiene, Zhenjiang Medical College.
J
J
Gao
C
C
Ren
Q
Q
Zhang
D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D017354:Point Mutation; D011110:Polymorphism, Genetic
D019389:Cytochrome P-450 CYP2D6; D005982:Glutathione Transferase