Development of acute lymphoblastic leukemia in a child after treatment of Langerhans cell histiocytosis: report of one case.
Langerhans cell histiocytosis (LCH) is a group of poorly understood disorders. To our knowledge, LCH is a non-malignant disorder. The association of LCH with a secondary neoplasm has not been well assessed, however, a few cases have been reported. We report a case of LCH, a localized osteolytic lesion over metaphysis of left femur, who was treated with local curettage and chemotherapy with vincristine, prednisone and 6-mercaptopurine (6-MP) for eight months from end of 1991 to August, 1992. Six years later, she had acute lymphoblastic leukemia (ALL) in 1998. In review of current literature, only 5 cases of LCH, including our case, have preceded ALL. The possible association, a reactive process or a therapy-related process, between LCH and acute leukemia is still unclear at present and needs to be explored by more studies in the future.
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
J H
JH
Wu
M Y
MY
Lu
K H
KH
Lin
S T
ST
Jou
D T
DT
Lin
D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000628:therapy; D006801:Humans; D007223:Infant; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology*