Antiulcerogenic effects of Tylophora conspicua in male rats.
Studies were undertaken on the effect of a crude (TC) and an alkaloid fraction (TA) of the leaf extracts of Tylophora conspicua on indomethacin-induced gastric ulceration and gastric acid secretion in male albino rats. Both the TC and TA produced a dose-dependent inhibition of gastric ulceration. At a dose level of 40 mg/kg TC and TA were more effective (TA being more potent) than propranolol in inhibiting gastric ulceration. The highest dose of the extracts used (80 mg/kg) completely inhibited gastric ulceration. Intravenous administration of the TC and TA significantly decreased acid output at low dose (20 mg/kg), medium dose (40 mg/kg) and high dose (80 mg/kg) from the peak basal of 0.54 +/- 0.02 mEq/L/min to 0. 49 +/- 0.02 mEq/L/min, 0.35 +/- 0.01 mEq/L/min and 0.21 +/- 0.02 Meq/L/min respectively. 80 mg/kg of TC and TA significantly reduced the histamine (1 mg/kg) induced gastric acid secretion. The results suggest that the antiulcer activity of Tylophora conspicua might be produced by gastric acid inhibition.
Raji
Y
Y
Department of Physiology, College of Medicine, University of Ibadan, Nigeria.
Hammed
A I
AI
Adesanwo
J K
JK
Ogunwande
I A
IA
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism; D007213:Indomethacin; D007275:Injections, Intravenous; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000470:Alkaloids; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D007213:Indomethacin