Hepatocyte growth factor in renal regeneration, renal disease and potential therapeutics.
Hepatocyte growth factor (HGF) has mitogenic, motogenic, morphogenic, and anti-apoptotic activities on renal cells and is a potential renotropin for renal protection and repair. In chronic renal failure/fibrosis, HGF in the kidney declines in a reciprocal manner to the increase in transforming growth factor-beta (TGF-beta). Neutralization of HGF by the antibody leads to acceleration of renal failure/fibrosis while HGF administration leads to remarkable attenuation, thus indicating the importance of HGF versus TGF-beta counterbalance in both pathogenesis and therapeutics in cases of chronic renal failure. HGF is being strongly considered for potential treatment of acute and chronic renal failure.
Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Japan.
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K
Matsumoto
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Mizuno
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Nakamura
D000818:Animals; D017228:Hepatocyte Growth Factor / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology* / Q000503:physiopathology; D007674:Kidney Diseases / Q000503:physiopathology* / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy; D012038:Regeneration / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
D016212:Transforming Growth Factor beta; D017228:Hepatocyte Growth Factor