Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation.
Tacrolimus is increasingly used for graft-versus-host disease (GVHD) prophylaxis and therapy in the allogeneic stem cell transplant (allo-SCT) setting. Pancreatitis, previously described as a side-effect of cyclosporine, has not been reported in allo-SCT recipients receiving tacrolimus. We present here a case of acute pancreatitis in a 28-year-old patient with chronic myelogenous leukemia (CML) who received an unrelated umbilical cord blood transplant (UCBT) and tacrolimus for GVHD prophylaxis. On day +31 post-transplant, she developed severe acute pancreatitis with multiorgan failure, from which she recovered completely. Tacrolimus was the probable cause of pancreatitis in this patient.
University of Colorado Bone Marrow Transplant Program, Denver, CO 80262, USA.
Y
Y
Nieto
P
P
Russ
G
G
Everson
S I
SI
Bearman
P J
PJ
Cagnoni
R B
RB
Jones
E J
EJ
Shpall
D000328:Adult; D005260:Female; D005312:Fetal Blood; D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000628:therapy; D010195:Pancreatitis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D006435:Renal Dialysis; D016559:Tacrolimus / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous / Q000276:immunology*
D007166:Immunosuppressive Agents; D016559:Tacrolimus