Single-quantum coherence filter for strongly coupled spin systems for localized (1)H NMR spectroscopy.
A pulse sequence for localized in vivo (1)H NMR spectroscopy is presented, which selectively filters single-quantum coherence built up by strongly coupled spin systems. Uncoupled and weakly coupled spin systems do not contribute to the signal output. Analytical calculations using a product operator description of the strongly coupled AB spin system as well as in vitro tests demonstrate that the proposed filter produces a signal output for a strongly coupled AB spin system, whereas the resonances of a weakly coupled AX spin system and of uncoupled spins are widely suppressed. As a potential application, the detection of the strongly coupled AA'BB' spin system of taurine at 1.5 T is discussed.
Trabesinger
A H
AH
Institute of Biomedical Engineering and Medical Informatics, University of Zurich, Switzerland.
Mueller
D C
DC
Boesiger
P
P
D000818:Animals; D002138:Calibration; D002417:Cattle; D002951:Citrates / Q000737:chemistry; D003627:Data Interpretation, Statistical; D006801:Humans; D007294:Inositol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D011743:Pyrimidines / Q000737:chemistry; D011789:Quantum Theory; D013654:Taurine / Q000737:chemistry
D002951:Citrates; D011743:Pyrimidines; D013654:Taurine; D007294:Inositol; C070669:lithium citrate