Urinary steroid profile in adrenocortical tumors.
Determination of the urinary steroid profile has been proposed as a sensitive tool for diagnosing adrenocortical tumors. The urinary steroid profiles were determined for patients with adrenocortical tumors. Urinary steroids were extracted, derivatized to form methyloxime-trimethylsilyl ether and analyzed by gas chromatography/mass spectrometry. Patients with adrenal adenomas from primary hyperaldosteronism had increased metabolites of 18-hydroxycorticosterone and aldosterone, and those with Cushing's syndrome had elevated excretion of 11 -deoxycortisol, cortisol, 18-hydroxycortisol, and cortisone metabolites. In patients with adrenocortical carcinomas, increased levels of metabolites of 11-deoxycortisol or 33-hydroxy-5-ene steroids were observed. The urinary steroid profiles of adrenal adenomas and adrenocortical carcinomas were quite different, suggesting the diagnostic validity for discriminating malignant from benign diseases.
Kikuchi
E
E
Department of Urology, Keio University School of Medicine, Tokyo, Japan.
Yanaihara
H
H
Nakashima
J
J
Homma
K
K
Ohigashi
T
T
Asakura
H
H
Tachibana
M
M
Shibata
H
H
Saruta
T
T
Murai
M
M
D000236:Adenoma / Q000150:complications / Q000652:urine*; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000652:urine*; D002277:Carcinoma / Q000150:complications / Q000652:urine*; D003480:Cushing Syndrome / Q000652:urine; D003937:Diagnosis, Differential; D006801:Humans; D006929:Hyperaldosteronism / Q000209:etiology / Q000652:urine; D013256:Steroids / Q000652:urine*
D013256:Steroids