Sophisticated medical devices as local drug-delivery systems.
The sustained release of antimicrobial substances from catheters, endoprostheses, wound-dressings and arterial grafts may be prudent for the prevention of device-associated infections. The release of heparin, synthetic prostacycline, hirudin and anti-inflammatory dexamethasone and related compounds from stent coatings may further reduce the risk of thrombosis, intimal hyperplasia and the requirement for long-term anticoagulation treatments. The delivery of cytokines and growth factors from wound dressings and bone grafts may accelerate wound healing and implant integration.
Institute for Scientific Evaluation of Naturopathy, University of Cologne, Germany.
J M
JM
Schierholz
J
J
Beuth
D000890:Anti-Infective Agents / Q000008:administration & dosage; D000925:Anticoagulants / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000009:adverse effects; D004864:Equipment and Supplies; D006801:Humans; D011108:Polymers
D000890:Anti-Infective Agents; D000925:Anticoagulants; D011108:Polymers