The rat vertex-middle latency auditory-evoked potential as indicator of anaesthetic depth: a comparison with evoked-reflex testing.
We investigated whether components from the rat Vx-MLAEP could be used to assess depth of anaesthesia induced by propofol. Propofol decreased MLAEP amplitudes and increased latencies. We propose that the P(16)-N(22) wave in the rat MLAEP is similar to the human P1, and that recovery of this wave during propofol anaesthesia correlates with behavioural measures of the regaining of consciousness.
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, NL-3508 TD, Utrecht, The Netherlands. z.l.haberham@las.vet.uu.nl
Z L
ZL
Haberham
W E
WE
van den Brom
A J
AJ
Venker-van Haagen
H N
HN
de Groot
V
V
Baumans
L J
LJ
Hellebrekers
D000758:Anesthesia / Q000379:methods*; D000818:Animals; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D008297:Male; D015742:Propofol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects* / Q000502:physiology
D015742:Propofol