Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease.
Patients with celiac disease are at high risk of having autoimmune disorders. Moreover, untreated patients with celiac disease have been found to have a higher than expected prevalence of organ-specific autoantibodies. In a prospective study of 90 patients with celiac disease, we found that the prevalence of diabetes and thyroid-related serum antibodies was 11.1% and 14.4%, respectively. Like antiendomysium autoantibodies, these organ-specific antibodies seem to be gluten-dependent and tend to disappear during a gluten-free diet.
Clinica Pediatrica e Laboratorio di Analisi, IRCCS "Burlo Garofolo" Trieste, Trieste, Italy.
A
A
Ventura
E
E
Neri
C
C
Ughi
A
A
Leopaldi
A
A
Città
T
T
Not
D016022:Case-Control Studies; D002446:Celiac Disease / Q000178:diet therapy / Q000453:epidemiology*; D002648:Child; D015897:Comorbidity; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D005983:Glutens / Q000009:adverse effects*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D013967:Thyroiditis, Autoimmune / Q000453:epidemiology* / Q000517:prevention & control
D005983:Glutens