[Percutaneous transfemoral arterial implantation of drug delivery system for arterial infusion therapy of advanced primary hepatic carcinoma].
OBJECTIVE
To study the efficiency of arterial infusion chemotherapy via drug delivery system (DDS) for advanced primary hepatic carcinoma.


METHODS
Hepatic arterial infusion chemotherapy was performed in 82 cases of primary hepatic carcinoma with no indication for operation or transarterial embolism treatment. The patients were divided into 2 group as follows: (1) Group A: 42 patients were treated intra-arterially once every 1 or 2 weeks via implanted DDS. (2) Group B: 40 patients were treated through one bolus arterial infusion chemotherapy, once every month.


RESULTS
The response rate (CR + PR) was 38.1% and 15.0% respectively in group A and B (P < 0.05); the 0.5-, 1- and 2- year survival rate was 61.9%, 28.6% and 9.5% respectively in group A, but 20%, 5%, 0% respectively in group B (P < 0.01); Liver, biliary, gastrointestinal and bone marrow toxicity in group A patients was greatly lower than those in group B patients.


CONCLUSIONS
Intermittent arterial infusion chemotherapy via DDS significantly improves survival and quality of life in patients with advanced primary hepatic carcinoma.
Department of Radiology, 3rd affiliated Hospital, Sun Yatsen University of Medical Science, Guangzhou.
K
K
Zhu
G
G
Hu
W
W
Liang
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009367:Neoplasm Staging; D011446:Prospective Studies; D015996:Survival Rate
D016685:Mitomycin; D003907:Dexamethasone; D016190:Carboplatin