New variotin analogues from Aspergillus viridi-nutans.
Besides the antifungal agents variotin (1), wasabidienone B(0) (4), and phomaligin A (5), two new but inactive metabolites, viriditin (2) and O-methylviriditin (3), were isolated from extracts of the culture filtrate of liquid cultures of a strain of Aspergillus viridi-nutans. In addition, wasabidienone B(1) (6) was isolated and characterized by spectroscopy.
Department of Biotechnology, University of Kaiserslautern, Paul-Erlich-Strasse 23, D-67663, Kaiserslautern, Germany.
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D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D011760:Pyrrolidinones; C001405:pecilocin