[Comparative studies of the pharmacokinetics of 131I-3H11 after different routes of administration].
OBJECTIVE
To study the pharmacokinetics of 131I-3H11, a mAb to gastric cancer, by different routes of administration.


METHODS
Three groups of rabbits were injected with 131I-3H11 through ear vein(i.v.), portal vein(pv) and into the peritoneal cavity(i.p.), respectively. At various time intervals, blood samples from the ear vein and portal vein, and the peritoneal fluid were collected and their radioactivities determined.


RESULTS
(1) The radioactivity of ear vein blood and portal vein blood was the same in the i.v. group. In the peritoneal cavity, it was 1/3 of that in the blood. (2) In pv group, radioactivity of the portal vein blood was higher than that of the ear vein blood, but the difference became insignificant 30 min later. In the peritoneal cavity, it was 1/3 of that in the blood. (3) In i.p. group, radioactivity in the peritoneal cavity was highest, its peak activity was 37.2-fold and 5.4-fold as high as that of the venous blood, respectively. That in the portal vein blood was 6.9 times higher than in the ear vein blood.


CONCLUSIONS
There is a significant pharmacokinetic advantage for i.p. over i.v. and pv routes of administration for the prevention and treatment of peritoneal recurrence and liver metastsis of gastrointestinal cancers after surgical resection.
Lu
D
D
Beijing Institute for Cancer Research.
Xu
G
G
Zhang
M
M
D000818:Animals; D000911:Antibodies, Monoclonal; D005260:Female; D000922:Immunotoxins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D011169:Portal Vein; D011817:Rabbits; D011897:Random Allocation; D013274:Stomach Neoplasms / Q000276:immunology*; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D007457:Iodine Radioisotopes