A case of classic Kaposi's sarcoma in a Japanese man: detection of human herpes virus 8 (HHV-8) infection by means of polymerase chain reaction and immunofluorescence assay.
The recently discovered human herpes virus 8 (HHV-8) has been implicated in the pathogenesis of Kaposi's sarcoma (KS). Because classic KS in Japan is rare and the detection of HHV-8 DNA by polymerase chain reaction (PCR) has been successful only in limited cases, the frequency and role of HHV-8 infection in KS in Japan remain unclear. Herein we report a case of classic KS in a Japanese man whose HHV-8 infection was confirmed by the detection of lesional viral DNA and serum antibodies against lytic antigen.
Yamada
Y
Y
Department of Dermatology, Kobe University School of Medicine, Japan.
Funasaka
Y
Y
Nishioka
E
E
Okuno
T
T
Ichihashi
M
M
D000368:Aged; D001483:Base Sequence; D001707:Biopsy, Needle; D019084:Fluorescent Antibody Technique, Indirect; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D015552:Injections, Intralesional; D016898:Interferon-alpha / Q000008:administration & dosage; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D016896:Treatment Outcome
D016898:Interferon-alpha