Tbx12, a novel T-box gene, is expressed during early stages of heart and retinal development.
T-box genes encode transcription factors that regulate many developmental processes. We have cloned a novel mouse T-box gene, Tbx12. Tbx12 is the vertebrate homologue of the Drosophila H15 gene and the Caenorhabditis elegans tbx-12 gene. Tbx12 is expressed in extraembryonic tissues such as the amnion and allantois. In the embryo, Tbx12 is strongly expressed in the neural retina and the heart.
MCD Biology, University of Colorado, Boulder, CO 80309-0347, USA.
C T
CT
Carson
E R
ER
Kinzler
B A
BA
Parr
D000482:Allantois / Q000378:metabolism; D000595:Amino Acid Sequence; D000650:Amnion / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000196:embryology; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000196:embryology; D004622:Embryo, Mammalian / Q000378:metabolism; D004625:Embryo, Nonmammalian; D006321:Heart / Q000196:embryology*; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D012160:Retina / Q000196:embryology*; D020825:T-Box Domain Proteins; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D020825:T-Box Domain Proteins; C486013:Tbx20 protein, mouse; D014157:Transcription Factors