Treatment of post transfusion graft-versus-host disease.
OBJECTIVE
In Japan, so many cases of post-transfusion graft-versus-host disease (PT-GVHD) have been reported, and no effective treatment has been reported.


METHODS



RESULTS
Totally 61 cases of PT-GVHD have been collected, and their background were analyzed. A serine protease inhibitor, nafamostat mesilate(N.M.) was examined as a drug for treatment of PT-GVHD using 4 patients.


RESULTS
N.M. was confirmed to inhibit cytotoxic activities of established cytotoxic T cell (CTL) clones in vitro. Simultaneously it was confirmed that fever and skin rash disappeared and liver function tests were normalized soon after the administration of N.M. in all four cases. Leukopenia and thrombocytopenia simultaneously improved.


CONCLUSIONS
The effects of N.M. seem to be limited to inhibit cytotoxic activity of CTL. In addition to this drug, how to remove the CTL from the patients will be the essentially important theme for the future.
Japanese Red Cross Central Blood Center, Tokyo, Japan. juji@cbc.jrc.or.jp
T
T
Juji
M
M
Nishimura
K
K
Tadokoro
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards; D001550:Benzamidines; D004341:Drug Evaluation; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D006146:Guanidines / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards; D006801:Humans; D008297:Male; D008875:Middle Aged; D015842:Serine Proteinase Inhibitors / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use; D065227:Transfusion Reaction; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001550:Benzamidines; D006146:Guanidines; D015842:Serine Proteinase Inhibitors; C032855:nafamostat