Anti-inflammatory and analgesic activity of Biebersteinia multifida DC. root extract.
The root of Biebersteinia multifida DC (Geraniaceae), a native plant of Iran, has been used topically for the treatment of musculoskeletal disorders as a folk medicine. The anti-inflammatory and analgesic effects of the root extract were studied using carrageenan induced edema and formalin tests. A similar activity was seen between Biebersteinia multifida root extract (10 mg/kg; i.p.) and indomethacin (4 mg/kg; i.p.) in carrageenan test. The results of formalin test showed the analgesic activity of the root extract (50 mg/kg; i.p.) was comparable with morphine (10 mg/kg; i.p.) at the first phase of formalin test. Furthermore, the probable ulcerogenic activity of the root extract was also studied. The extract did not show any ulcerogenic effect at anti-inflammatory doses (10 mg/kg; p.o.).
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, 14155-6451, Tehran, Iran. farsam@sina.tums.ac.ir
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H
Farsam
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Amanlou
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Reza Dehpour
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F
Jahaniani
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007492:Iran; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D007213:Indomethacin