[Inherent mdr-1 gene expression in fresh tumor tissue specimens from several high-incidence malignancies].
OBJECTIVE
To ascertain frequency of inherent mdr-1 gene expression in several common neoplasms.


METHODS
One hundred fifty one surgically resected tumor specimens confirmed pathologically to be malignant from preoperatively untreated cancer patients were studied. Expression of mdr-1 gene was examined by RT-PCR.


RESULTS
The frequency of primary mdr-1 gene expression was 33.3% for cancer of the stomach and gastric cardia (17/51), 37% for cancer of the esophagus (17/46), 31.3% for cancer of the colon and rectum (5/16), 13.2% for cancer of the breast (2/15), 40.0% for cancer of the thyroid (4/10), 55.0% for cancer of the lung (5/9) and 0% for cancer of the uterine cervix (0/4).


CONCLUSIONS
Primary mdr-1 gene expression is relatively of frequent occurrence as detected by RT-PCR technique.
Anyang Tumor Hospital, Henan.
L
L
Yin
K
K
Chen
D
D
Li
D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D002299:Cardia; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D019450:Genes, MDR; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D013274:Stomach Neoplasms / Q000235:genetics*