Neoangiogenesis in the peritoneal membrane.
OBJECTIVE
This study reviews relevant publications on the peritoneal vasculature and tries to establish morphological-functional relationships.


METHODS
The design is a review article.


RESULTS
Recent morphological studies in peritoneal dialysis (PD) patients have shown the presence of diabetiform neoangiogenesis in long-term peritoneal dialysis. The same abnormalities could be induced in rats administered a high glucose dialysis solution daily for 20 weeks. The animals showed functional abnormalities in peritoneal transport similar to those found in long-term PD patients. Evidence was obtained in patients that vascular endothelial growth factor could be involved in glucose-induced peritoneal neoangiogenesis.


CONCLUSIONS
Diabetiform peritoneal neoangiogenesis is an important pathogenetic factor in ultrafiltration failure in long-term peritoneal dialysis patients.
Division of Nephrology, University of Amsterdam, The Netherlands.
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Krediet
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Zweers
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van der Wal
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Struijk
D000818:Animals; D015314:Dialysis Solutions / Q000633:toxicity; D016228:Endothelial Growth Factors / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000209:etiology* / Q000517:prevention & control; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010537:Peritoneum / Q000098:blood supply* / Q000378:metabolism; D010539:Permeability; D051381:Rats
D015314:Dialysis Solutions; D016228:Endothelial Growth Factors; D005947:Glucose