[Nucleoside diphosphate kinase/nm23H1 expression in ovarian epithelial carcinoma: retroperitoneal lymphatic metastasis and survival].
OBJECTIVE
To determine the relationship between NDPK(A) expression and retroperitoneal lymph node metastasis (LNM) and the significance of the prognosis in epithelial ovarian carcinoma.


METHODS
NDPK(A) expression of formalin-fixed parafin-beded samples, which included 74 primary, 31 intraperitoneal and 18 retroperitoneal lymph node metastatic tumors, were examined by ABC immunohistochemisty in 74 patients with primary ovarian cancer.


RESULTS
In the 74 primary lesions, 22 samples showed positive staining of NDPK(A) (30%). Positive staining was higher in patients without LNM(46%) than those with LNM (17%, P = 0.008); it was lower in menopausal patients (19%) than in menstruant (44%, P = 0.022). Compared with primary tumor, NDPK(A) expression appeared to decrease in lymph-node lesion(28% vs 39%, P > 0.1) but to increase in intraperitoneal metastastic tumor (32% vs. 19%, P > 0.5). Multivariance analysis confirmed that the important risk factors for LNM were lower expression of NDPK(A), more large residual tumor and poor differentiation. But there was no any corelation between NDPK(A) expression and survia.


CONCLUSIONS
The study suggested that increased expression of NDPK(A)/nm23H1 is inversely related to LNM in epithelial ovarian carcinoma, but it can not confirm the prognostic significance of NDPK(A).
Cancer Hospital of Shanghai Medical University.
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Wu
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Zhang
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Shi
D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000235:genetics; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000096:biosynthesis*; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D012187:Retroperitoneal Space; D014157:Transcription Factors / Q000096:biosynthesis*
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins