Arterial to end-tidal carbon dioxide pressure difference during laparoscopic surgery in pregnancy.
BACKGROUND
There is controversy about whether capnography is adequate to monitor pulmonary ventilation to reduce the risk of significant respiratory acidosis in pregnant patients undergoing laparoscopic surgery. In this prospective study, changes in arterial to end-tidal carbon dioxide pressure difference (PaCO2--PetCO2), induced by carbon dioxide pneumoperitoneum, were determined in pregnant patients undergoing laparoscopic cholecystectomy.


METHODS
Eight pregnant women underwent general anesthesia at 17-30 weeks of gestation. Carbon dioxide pnueumoperitoneum was initiated after obtaining arterial blood for gas analysis. Pulmonary ventilation was adjusted to maintain PetCO2 around 32 mmHg during the procedure. Arterial blood gas analysis was performed during insufflation, after the termination of insufflation, after extubation, and in the postoperative period.


RESULTS
The mean +/- SD for PaCO2--PetCO2 was 2.4 +/- 1.5 before carbon dioxide pneumoperitoneum, 2.6 +/- 1.2 during, and 1.9 +/- 1.4 mmHg after termination of pneumoperitoneum. PaCO2 and pH during pneumoperitoneum were 35 +/- 1.7 mmHg and 7.41 +/- 0.02, respectively. There were no significant differences in either mean PaCO2--PetCO2 or PaCO2 and pH during various phases of laparoscopy.


CONCLUSIONS
Capnography is adequate to guide ventilation during laparoscopic surgery in pregnant patients. Respiratory acidosis did not occur when PetCO2 was maintained at 32 mmHg during carbon dioxide pneumoperitoneum.
Departments of Anesthesia and Surgery, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Bhavani@capnography.com
K
K
Bhavani-Shankar
R A
RA
Steinbrook
D C
DC
Brooks
S
S
Datta
D000704:Analysis of Variance; D000768:Anesthesia, General; D019296:Capnography; D002763:Cholecystectomy; D005260:Female; D006801:Humans; D010535:Laparoscopy; D011027:Pneumoperitoneum / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000601:surgery*; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange