Serum antibodies in celiac disease.
Celiac disease is characterized by small intestinal damage which often leads to global malabsorption. For diagnosis an intestinal biopsy to demonstrate the mucosal changes is mandatory. However, serological tests are useful additional tools to confirm the diagnosis and to monitor therapy. These serological tests, which are based on the detection of antibodies against gliadin and autoantibodies against components of the extracellular matrix, are described in this article.
Friedrich-Alexander-Universität Erlangen-Nürnberg Medizinische Klinik I, Germany. walburga.dieterich@med1.imed.uni-erlangen.de
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D001323:Autoantibodies / Q000097:blood*; D002446:Celiac Disease / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D016326:Extracellular Matrix Proteins / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007413:Intestinal Mucosa / Q000473:pathology
D001323:Autoantibodies; D016326:Extracellular Matrix Proteins; D007070:Immunoglobulin A; D005903:Gliadin