[Chemotherapy by isolated liver perfusion with endovascular occlusion catheter: preliminary experience in pigs].
Very high concentrations of cytotoxic drug may be obtained with chemotherapy performed with vascular exclusion.


OBJECTIVE
To study the pharmacokinetics and toxicity of melphalan during in situ isolated liver perfusion, and to test an endovascular occlusion catheter.


METHODS
Isolated liver perfusion with melphalan (15 mg bolus) was performed in 6 pigs (50-60 kg) for 30 min, with non-oxygenated Ringer's solution. Hepatic outflow, collected by a double balloon catheter inserted into the retrohepatic inferior vena cava, was pumped into the gastroduodenal artery, while the common hepatic artery and portal vein were clamped.


RESULTS
A maximum concentration of 30,000 ng/mL was obtained in the circuit before an exponential decrease, while the concentration in systemic blood was less than 500 ng/mL (n = 3). Before closing the abdomen, melphalan concentrations were about 2,000 ng/mg in the liver, and undetectable in the muscle. Postoperative course (2 weeks, n = 2) was uneventful with minor alterations in blood tests and hepatic histology.


CONCLUSIONS
This method of local chemotherapy with melphalan appears to be safe with minor leakage and minimal toxicity.
Centre hépato-biliaire, hôpital Paul-Brousse, Villejuif, France.
E
E
Savier
F
F
Lokiec
S
S
Le Fur
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D002404:Catheterization; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D013552:Swine; D014682:Vena Cava, Inferior
D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan