Nitric oxide--angiotensin II axis in renal and cardiovascular injury.
The knowledge and the information about Renin Angiotensin System and Arginine-Nitric Oxide pathway helped us in understanding more about cardiac, vascular and renal systems, their function, the physiology, and pathophysiology of different diseases that may affect them. The existence of a Nitric Oxide/Angiotensin II axis, brought modification to our ways of thinking with new and more pathophysiological approaches to the treatment of hypertension and end-organ disease. There appears to be a link between hypertension, salt sensitivity, endothelial function and NO-AnglI axis on one side and end organ damage on the other side. Anti-hypertensive agents that can restore endothelial function beside their antihypertensive effect, may be better in preventing or at least slowing end-organ damage.
Adam
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Department of Veterans Affairs Medical Center and University of Minnesota, Minneapolis 55417, USA.
Raij
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D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*
D000804:Angiotensin II; D009569:Nitric Oxide