A pilot study of protein sparing in healthy dogs using peripheral parenteral nutrition.
Total parenteral nutrition is the standard nutritional support of dogs when the enteral route is contraindicated, but it can be difficult because of cost, technical difficulties, and potential complications. Peripheral parenteral nutrition (PPN) may be a feasible option for short-term support in some cases. The objectives of this study were to determine the effect of PPN on nitrogen balance (as an indicator of the effect on protein sparing), serum folate concentrations and serum insulin-like growth factor-I (IGF - I) concentrations in fasting dogs. The effect of PPN on these parameters has not previously been reported in dogs. Using a cross-over design, three healthy adult fasting dogs were randomly assigned to three treatments: 5 per cent amino acid solution, 5 per cent glucose solution, and a control electrolyte solution. The solutions were administered into a peripheral vein at 60 ml kg(-1)per day for 4 days. The amino acid infusion resulted in a positive nitrogen balance and the glucose infusion produced less nitrogen loss than the control. Amino acid, but not glucose or electrolyte infusions, decreased serum folate concentrations. Amino acid and glucose infusions resulted in higher serum IGF -I concentrations than electrolyte infusions, although the differences were small and IGF -I decreased in all cases. In conclusion, these findings suggest that PPN increases nitrogen balance in healthy dogs undergoing short-term fasting.
Chandler
M L
ML
Institute for Veterinary Animal and Biomedical Science, Massey University, Palmerston North, New Zealand. mchandler@vet.ed.ac.uk
Guilford
W G
WG
Maxwell
A
A
Barter
L
L
D000596:Amino Acids / Q000008:administration & dosage; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D002406:Catheterization, Peripheral / Q000662:veterinary; D018592:Cross-Over Studies; D004285:Dogs / Q000378:metabolism* / Q000502:physiology; D004573:Electrolytes / Q000008:administration & dosage; D005260:Female; D005492:Folic Acid / Q000097:blood; D005508:Food Deprivation / Q000502:physiology*; D005947:Glucose / Q000008:administration & dosage; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D009584:Nitrogen / Q000652:urine*; D009752:Nutritional Status / Q000502:physiology; D010288:Parenteral Nutrition / Q000662:veterinary*; D010865:Pilot Projects; D011506:Proteins / Q000378:metabolism*; D011897:Random Allocation; D000077325:Ringer's Lactate; D016482:Urinalysis / Q000662:veterinary
D000596:Amino Acids; D004573:Electrolytes; D007552:Isotonic Solutions; D011506:Proteins; D000077325:Ringer's Lactate; D007334:Insulin-Like Growth Factor I; D005492:Folic Acid; D005947:Glucose; D009584:Nitrogen