Antimicrobial activity of crude extracts and pure compounds of Hypericum hircinum.
The antimicrobial activity of the n-hexane (H) and chloroform (C) extracts, the methanol extract (M) and its ethyl acetate (E) and n-butanol (B) fractions, and six isolated constituents of the aerial parts of Hypericum hircinum was investigated using an agar diffusion method. The maximum activity was exhibited by the methanolic extract against Staphylococcus aureus, while all pure constituents showed no antimicrobial activity against the tested microorganisms.
Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, via Bonanno 33, 56126 Pisa, Italy. luipi@farm.unipi.it
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Pistelli
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Bertoli
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Zucconelli
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Morelli
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Panizzi
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Menichini
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D020902:Hypericum; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010936:Plant Extracts