Heparin-free hemodialysis in the treatment of hypernatremia in severely burned patients.
BACKGROUND
Hypernatremia in severely burned patients is associated with high morbidity and mortality rates. As the causes of hypernatremia in major burn patients are still not clear, hemodialysis is the method of choice for the treatment. While hemodialysis is effective for the control of hypernatremia, it can cause bleeding complications that may be fatal for burn patients with extensive wounds and potential gastro-intestinal mucosal damage.


METHODS
In the present study heparin-free hemodialysis in which the heparin is firmly absorbed to the haemofiltration membrane, hemophan, dispensed with systemic use of heparin. In two extensively burned patients with burn area of 100% TBSA and 98% TBSA respectively and hypernatremia with serum sodium concentration as high as 169 and 158 mmol/l respectively, heparin-free hemodialysis was performed five times and three times each.


RESULTS
Hypernatremia was satisfactorily corrected with no interference to the coagulation system in the two patients as indicated by clinical observation and biochemical analysis. The patient with burn area of 98% TBSA survived and the patient with burn area of 100% TBSA died of wound coverage failure 6 weeks after injury because of non-availability of autograft.


CONCLUSIONS
Heparin-free hemodialysis is an effective and safe method in the treatment of hypernatremia in extensively burned patients.
Burns Institute, 304th Hospital, 100037, Beijing, People's Republic of China.
J
J
Chai
L
L
Diao
Z
Z
Sheng
Z
Z
Guo
W
W
Gao
X
X
Jia
D000328:Adult; D002056:Burns / Q000150:complications* / Q000175:diagnosis; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006493:Heparin; D006801:Humans; D006955:Hypernatremia / Q000209:etiology* / Q000628:therapy*; D015601:Injury Severity Score; D008297:Male; D008851:Micropore Filters; D006435:Renal Dialysis / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome
D006493:Heparin