Acute and subacute toxicity of Cochlospermum regium (Mart. & Schr.) pilger.
The toxicity of a hydroethanol extract of the subterranean part of Cochlospermum regium was evaluated in mice and rats. The extract had moderate acute toxicity when administered intraperitoneally and low toxicity upon oral administration. A subacute toxicity test revealed that the extract is well tolerated by these animals.
Toledo
M I
MI
Depto. de Farmácia-bioquímica, Universidade Federal de Mato Grosso do Sul, Brazil.
Siqueira
J M
JM
Araújo
L C
LC
Oga
S
S
D000284:Administration, Oral; D000818:Animals; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008297:Male; D019660:Malvaceae / Q000633:toxicity*; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity; D018517:Plant Roots; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects
D010936:Plant Extracts