The effect of topical adrenaline on the development of myringosclerosis after tympanostomy tube insertion.
OBJECTIVE
To determine the effect of topical adrenaline application after myringotomy and before tympanostomy tube placement on the development of myringosclerosis.


METHODS
A prospective, randomized, double-blind study, with each patient acting as his or her own control. Ethical approval and full parental consent were obtained.


METHODS
Department of Otorhinolaryngology-Head and Neck Surgery in a university teaching hospital.


METHODS
Fifty children satisfying inclusion and exclusion criteria for first-time tympanostomy tube insertion. THERAPEUTIC INTERVENTION: Myringotomy followed by adrenaline application to incision before tympanostomy tube insertion. Control contralateral ear received saline application after myringotomy. Follow-up examination was done 14 to 21 days after surgery and again after 1 year by a single blinded surgeon.


METHODS
Comparison of myringosclerosis between adrenaline-treated ears and matched control ears.


RESULTS
No difference was found in early morbidity between the two groups of ears. Myringosclerosis after 1 year was not found to have been significantly affected by adrenaline application (p = 0.2)


CONCLUSIONS
The use of adrenaline on the myringotomy site before tympanostomy tube placement was not found to influence early postoperative morbidity or the later development of myringosclerosis.
Department of Otorhinolaryngology/Head and Neck Surgery, Leicester Royal Infirmary, UK.
A R
AR
Banerjee
C
C
Jennings
J N
JN
Marshall
A A
AA
Narula
D000287:Administration, Topical; D002648:Child; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D008876:Middle Ear Ventilation / Q000009:adverse effects*; D009017:Morbidity; D010040:Otosclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D011446:Prospective Studies; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*
D014662:Vasoconstrictor Agents; D004837:Epinephrine