Using an analogous monoclonal antibody to evaluate the reproductive and chronic toxicity potential for a humanized anti-TNFalpha monoclonal antibody.
Treacy
G
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Centocor, Inc., Malvern, Pennsylvania 19355, USA.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000633:toxicity*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007246:Infertility / Q000139:chemically induced*; D000069285:Infliximab; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*; D013723:Teratogens / Q000633:toxicity; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D000911:Antibodies, Monoclonal; D013723:Teratogens; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab