A PET study of adenosine A1 receptor in anesthetized monkey brain.
We demonstrated the distribution of adenosine A1 receptors in the anesthetized monkey brain with positron emission tomography (PET) using [(11)C]KF15372 ([1-propyl-(11)C]8-dicyclopropylmethyl-1, 3-dipropylxanthine). [(11)C]KF15372 was injected intravenously. The regional standardized uptake values and the distribution volume were calculated. We also investigated the effect of carrier on the uptake and regional brain distribution of [(11)C]KF15372. The use of [(11)C]KF15372 with dynamic PET scanning could be an appropriate method to analyze the regional binding potential of adenosine A1 receptors in living brain.
Wakabayashi
S
S
Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.
Nariai
T
T
Ishiwata
K
K
Nagaoka
T
T
Hirakawa
K
K
Oda
K
K
Sakiyama
Y
Y
Shumiya
S
S
Toyama
H
H
Suzuki
F
F
Senda
M
M
D000758:Anesthesia; D000818:Animals; D001923:Brain Chemistry; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D005260:Female; D008252:Macaca fascicularis; D018047:Receptors, Purinergic P1 / Q000032:analysis*; D014055:Tomography, Emission-Computed; D014970:Xanthines / Q000378:metabolism*
D002250:Carbon Radioisotopes; D018047:Receptors, Purinergic P1; D014970:Xanthines; C067197:8-(dicyclopropylmethyl)-1,3-dipropylxanthine