Grapefruit: the last decade acquisitions.
This review reports the last decade acquisitions on grapefruit. New coumarins and limonoids were isolated and characterised. The bioavailability of many drugs was tested with grapefruit juice (GJ) coadministration; the inhibition on cytochrome P450 seems due to a synergic action between flavonoids and coumarins. Antimicrobial, antifeeding, insecticidal, and antitumour activities were also reported.
Istituto di Botanica, Università di Urbino Via Bramante, 28-61029, Urbino, Italy.
B
B
Tirillini
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D001628:Beverages; D001682:Biological Availability; D032083:Citrus paradisi; D003374:Coumarins / Q000493:pharmacokinetics; D004357:Drug Synergism; D006801:Humans; D007306:Insecticides; D008517:Phytotherapy; D010936:Plant Extracts; D010938:Plant Oils
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D003374:Coumarins; D007306:Insecticides; D010936:Plant Extracts; D010938:Plant Oils