Management of gestational diabetes with a conservative insulin protocol.
OBJECTIVE
To investigate whether 2-hour postprandial blood glucose levels up to 8.0 mmol/L affect maternal or neonatal outcomes in pregnancies complicated by gestational diabetes mellitus (GDM).


METHODS
Retrospective analysis of data collated by the Victorian Perinatal Data Collection Unit.


METHODS
394 GDM women and 394 control women matched for age and country of birth who gave birth at a university teaching hospital, 1991-1997.


METHODS
Maternal--hypertension/pre-eclampsia, obstetric intervention, gestation at delivery, length of hospital stay; neonatal--Apgar scores, time to establish respiration, birthweight, macrosomia, large or small for gestational age (LGA or SGA), fetopelvic disproportion, jaundice, hypoglycaemia.


RESULTS
For most outcome measures there were no statistically significant differences between the GDM and control groups. However, in the GDM group, gestation was shorter, hospital stays longer and delivery interventions more common.


CONCLUSIONS
Our study suggests that maternal and neonatal outcomes in GDM women are comparable with those of women without GDM when 2-hour postprandial glucose levels of up to 8mmol/L are maintained. This is 1.0 mmol/L higher than the current Australian Diabetes in Pregnancy Society recommendation.
Simpson
R W
RW
Box Hill Hospital, Melbourne, VIC. simptron@ozemail.com.au
Kast
S J
SJ
D001034:Apgar Score; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D036861:Delivery, Obstetric; D016640:Diabetes, Gestational / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000150:complications; D007003:Hypoglycemia / Q000209:etiology; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D007567:Jaundice, Neonatal / Q000209:etiology; D007902:Length of Stay; D007744:Obstetric Labor Complications / Q000209:etiology; D011225:Pre-Eclampsia / Q000150:complications; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D012119:Respiration; D012189:Retrospective Studies
D001786:Blood Glucose; D007328:Insulin