Hepatoprotective diastereomeric lignans from Saururus chinensis herbs.
Two new diastereomeric sauchinones (2, 3), along with the known sauchinone (1), a phenylpropanoid (sarisan), and two known lignans (galbacin and saucernetin), were isolated from the n-hexane fraction of Saururus chinensis using reversed-phase HPLC. The stereostructures of the lignans, sauchinone A (2) and 1'-epi-sauchinone (3), were established by analysis of spectroscopic data. Incubation of cultured rat hepatocytes intentionally injured by CCl(4) with each of the compounds 1, 2, and 3 significantly reduced the levels of glutamic pyruvic transaminase released by the damaged hepatocytes.
Sung
S H
SH
College of Pharmacy, Seoul National University, Seoul, 151-742, Korea.
Kim
Y C
YC
D000818:Animals; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013057:Spectrum Analysis; D013237:Stereoisomerism
D017705:Lignans