Parathyroid hormone-related peptide and Indian hedgehog.
Normal endochondral bone development requires temporal and spatial coordination of various cell types. Parathyroid hormone-related peptide and Indian hedgehog interact with each other and form a feedback loop that plays a major role in this coordination. Defects in the signalling of either of the two molecules cause severe bone malformations.
Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA. chungu@helix.mgh.harvard.edu
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D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000002:abnormalities*; D004627:Embryonic Induction / Q000502:physiology; D053823:Hedgehog Proteins; D006801:Humans; D010012:Osteogenesis / Q000502:physiology*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators
D053823:Hedgehog Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D015534:Trans-Activators