[Precarcinoma and early carcinomatous lesions in the uterine cervix and the use of oral contraceptives].
Precancerous and early cancerous lesions of the cervix uteri (ASCUS, AGUS, LSIL and HSIL) are precursors of invasive cancer of the cervix uteri. By Papanicolaou test they are graded as Pap III and Pap IV. Different factors may increase a risk for those lesions as well as converting low stage lesion into higher one. Oral contraceptive use is one of the most potential risk factor for those lesions. The goal of this study was to examine a relationship between oral contraceptive use and precancerous and early cancerous lesion of the cervix lesion of the cervix uteri by using Papanicolaou test. After adjustment for other potential risk factors our results have shown: 1) there is high significant positive relationship between oral contraceptives use and precancerous and early cancerous lesions of the cervix uteri; 2) the users of oral contraceptives have shown Pap III and Pap IV smear grade five to ten years earlier than non-users; 3) long-term users have shown Pap III and Pap IV five years earlier than short-term users for middle age group (35-44 years); 4) the border between Pap III and Pap IV is shifted for five years toward earlier age.
Ljuca
D
D
Ginekolosko-akuserska klinika, Univerzitetsko-klinicki Centar u Tuzli.
Fatusić
Z
Z
Mujagić
H
H
Ljuca
F
F
Alispahić
N
N
D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D065006:Papanicolaou Test; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000175:diagnosis; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced* / Q000175:diagnosis; D014626:Vaginal Smears
D003276:Contraceptives, Oral