[Interleukin-6 and its soluble receptors in human breast cancer].
OBJECTIVE
To study interleukin-6(IL-6) and its receptors in human breast cancer.


METHODS
Using ELISA method and ABC immunohistochemistry, IL-6 and its receptors were examined in 45 cases of breast cancer, 10 cases of benign breast diseases and 17 cases of healthy women.


RESULTS
High levels of serum IL-6 and its soluble receptors were frequently observed in breast cancer patients. The levels correlated with the stage and axillary lymph node involvement. The positive staining of IL-6, IL-6R alpha, gp130 were 68.9% in neoplasm tissue.


CONCLUSIONS
IL-6 and its soluble receptors may be important paramenters reflecting the biological behaviour and prognosis of breast cancer.
Surgery Department, First Affiliated Hospital, Suzhou Medical College.
Y
Y
Kuang
Z
Z
Zhang
X
X
Zhang
D001943:Breast Neoplasms / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D019947:Receptors, Interleukin-6 / Q000097:blood*
D015850:Interleukin-6; D019947:Receptors, Interleukin-6