[Effect of the novel aminoadamantane derivative A-7 on Parkinsonian syndrome induced by systemic administration of neurotoxin MPTP].
A new antiparkinsonian drug, N-(2-adamantyl)hexamethyleneimine hydrochloride (A-7), was studied on the model of parkinsonism syndrome (PS) induced by MPTP neurotoxin. A-7 (5-20 mg/kg) attenuated the MPTP induced akinesia and rigidity manifestations in C57B1/6 mice, the effect being more pronounced than that of cyclodol and levodopa and comparable to that of midantane (amantadine). A-7 also decreased the PS manifestations in rats: removed tremor, rigidity, and oligokinesia, normalized the MPTP-violated bioelectrical activity of nucleus caudatus, sensomotor cortex, and dorsal hippocamp, and eliminated pathologic slow activity, paroxysmal discharges, and high-frequency activity discharges. The activity of A-7 exceeded that of levodopa (enhancing tremor) and cyclodol (not eliminating the pathologic slow activity).
Laboratory of Psychopharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
L N
LN
Nerobkova
E A
EA
Val'dman
T A
TA
Voronina
N V
NV
Markina
L M
LM
Sharkova
D000547:Amantadine / Q000627:therapeutic use; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004594:Electrophysiology; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D014282:Trihexyphenidyl / Q000627:therapeutic use; D014334:Tropolone / Q000031:analogs & derivatives
D000978:Antiparkinson Agents; D007980:Levodopa; C030370:2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone; D014282:Trihexyphenidyl; D014334:Tropolone; D000547:Amantadine