Matemone, a new bioactive bromine-containing oxindole alkaloid from the indian ocean sponge Iotrochota purpurea.
A new bioactive bromine-containing oxindole alkaloid, matemone (1), was isolated from the Indian Ocean sponge Iotrochota purpurea, together with the known 6-bromoindole-3-carbaldehyde. The structures were elucidated on the basis of spectral and chemical data. Compound 1 shows mild cytotoxicity against three cancer cell lines and marginal antibacterial activity against Staphyloccocus aureus. DNA intercalant screening demonstrated DNA interactions with 1. Both compounds inhibit division of sea-urchin eggs.
LPTE, Faculté des Sciences, Université de Nice Sophia-Antipolis, 28 Avenue de Valrose, 06108 Nice-Cedex 2, France.
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Carletti
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Banaigs
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Amade
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001966:Bromine / Q000032:analysis*; D002176:Candida albicans / Q000187:drug effects; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007211:Indoles; C413038:matemone; D001966:Bromine