Regulation of mammalian iron homeostasis.
Iron homeostasis is regulated with respect to uptake, storage and utilization. Newer work is presented that defines proteins responsible for iron transport, sequestration and sensing, and that addresses their regulation at the cellular and organismal levels by ambient iron concentrations, demand for erythropoiesis, body iron burden, and redox stimuli.
Department of Internal Medicine, University of Utah, Salt Lake City 84112, USA.
B D
BD
Schneider
E A
EA
Leibold
D000818:Animals; D006706:Homeostasis; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D035925:Iron-Regulatory Proteins; D007506:Iron-Sulfur Proteins / Q000235:genetics / Q000378:metabolism; D018384:Oxidative Stress; D012313:RNA / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D020218:Response Elements
D035925:Iron-Regulatory Proteins; D007506:Iron-Sulfur Proteins; D016601:RNA-Binding Proteins; D012313:RNA; D007501:Iron