[Round window microcatheter administered microdose of gentamycin: an alternative in the treatment of tinnitus in patients with Menière's disease].
BACKGROUND
In this study, we review the results of Menière's disease treatment using microdose gentamycin delivered directly to the round window using a new microcatheter system.


METHODS
11 patients were treated by 1.25 mg gentamycin on the 3rd and 7th day after insertion of the new microcatheter at the niche of the round window membrane, while a second group of 7 patients was treated by a gentamycin dosage of 1 microliter/h continuously applied by a minipump over a period of 10 days. Electrocochleography was derived by an integrated electrode and the microcatheter was removed after 10 days. The results were analysed with a follow-up ranging from 6 to 12 months.


RESULTS
In 15 of 18 patients (83%) tinnitus was improved significantly throughout the follow-up period. Vertigo was eliminated in all patients, and pressure was relieved in 17 of 18 (94%).


CONCLUSIONS
These preliminary data suggest that gentamycin delivered by the Round-Window-Microcatheter is a safe and effective treatment for the reduction of tinnitus, vertigo, and pressure associated with Menière's disease.
Prosper Meniere Society, Englewood, CO, USA.
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S
Marks
I K
IK
Arenberg
M E
ME
Hoffer
D001300:Audiometry, Evoked Response; D002404:Catheterization; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007260:Infusion Pumps; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy*; D012405:Round Window, Ear; D013997:Time Factors; D014012:Tinnitus / Q000188:drug therapy* / Q000209:etiology
D005839:Gentamicins