Linkage mapping of the ovine alpha-inhibin (INHA) beta(A)-inhibin/activin (INHBA) and beta(B)-inhibin/activin (INHBB) genes.
A full-sib mapping population was typed for Taql Southern blot RFLPs at the ovine alpha-inhibin (INHA), beta(A)-inhibin/activin (INHBA), and beta(B)-inhibin/activin (INHBB) loci. The most likely positions were found by genetic linkage analysis. INHA was placed on ovine chromosome 2q, between microsatellite markers BM6444 and INRA135, while INHBB was located 39 cM proximal to INHA between markers BMS1126 and BMS2626. The INHBA gene, a comparative mapping anchor locus, mapped to chromosome 4, between microsatellites OARCP26 and BMS719. These data confirm and refine previous chromosomal assignments by in situ hybridization, provide comparative mapping information, and identify microsatellite markers suitable for QTL association studies with inhibin/activin genes in ruminants.
Department of Animal Breeding and Genetics, Justus-Liebig-University, Giessen, Germany. Stefan.Hiendleder@agrar.uni-giessen.de
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Dodds
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Wassmuth
D028341:Activins; D000818:Animals; D015139:Blotting, Southern / Q000379:methods; D002874:Chromosome Mapping; D008040:Genetic Linkage; D028322:Inhibin-beta Subunits; D007265:Inhibins / Q000235:genetics*; D009842:Oligopeptides; D010455:Peptides / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012756:Sheep / Q000235:genetics*
D009842:Oligopeptides; D010455:Peptides; C044147:activin B; C103008:inhibin beta A subunit; C094377:inhibin-alpha subunit; D028341:Activins; C048617:myelopeptides; D007265:Inhibins; D028322:Inhibin-beta Subunits