Pre-B and pre-T-cell receptors: conservation of strategies in regulating early lymphocyte development.
Early lymphocyte development is characterized by the regulated activity of the V(D)J recombinase and the positive and negative selection of cells based on the structure of their assembled antigen receptor genes. Developing B and T cells use remarkably similar signaling complexes, the pre-B-cell receptor (pre-BCR) and the pre-T-cell receptor (pre-TCR) respectively, to monitor the progress of antigen receptor gene assembly This review will compare and contrast the regulation and activities of the pre-BCR and pre-TCR signaling complexes. In addition, we will consider a number of critical but as yet unanswered questions prompted by such an analysis.
Graduate Program in Immunology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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Muljo
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Schlissel
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D019070:Cell Lineage; D004792:Enzyme Precursors / Q000502:physiology; D015870:Gene Expression; D015322:Gene Rearrangement, B-Lymphocyte; D007147:Immunoglobulin Light Chains; D054444:Immunoglobulin Light Chains, Surrogate; D015851:Interleukin-7 / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D008213:Lymphocyte Activation; D020935:MAP Kinase Signaling System; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D013234:Stem Cells / Q000276:immunology; D000072377:Syk Kinase; D013601:T-Lymphocytes / Q000276:immunology*; D051746:ZAP-70 Protein-Tyrosine Kinase; D019061:src-Family Kinases / Q000502:physiology
D004792:Enzyme Precursors; D007147:Immunoglobulin Light Chains; D054444:Immunoglobulin Light Chains, Surrogate; D015851:Interleukin-7; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D000072377:Syk Kinase; C000606897:Syk protein, mouse; D051746:ZAP-70 Protein-Tyrosine Kinase; C497262:Zap70 protein, mouse; D019061:src-Family Kinases