Effects of bacterial glyceroglycolipid M874B on growth and TPA-induced differentiation of HL60 cells.
Bacterial monogalactosyldiacylglycerol M874B (MGDAG), which protects against oxygen radicals, was found to increase the growth of the human promyelocytic leukemia cell HL60 when added to the cell culture, but suppresses the 12-O-tetradecanoyl phorbol-13-acetate-induced differentiation. Analogous MGDAG, S365B had weak, but similar effects. These activities were not observed with analogous plant glyceroglycolipids and diacylglycerol.
Central Research Laboratories, Mercian Corporation, Fujisawa, Japan.
M
M
Matsufuji
Y
Y
Nagamatsu
A
A
Yoshimoto
D000192:Actinomycetales / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D038983:Galactolipids; D005690:Galactose / Q000494:pharmacology*; D005989:Glycerides / Q000494:pharmacology*; D006017:Glycolipids / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016166:Free Radical Scavengers; D038983:Galactolipids; D005989:Glycerides; D006017:Glycolipids; C412404:di-O-12-methyl-tetradecanoyl-3-O-galactopyranosyl-glycerol; D013755:Tetradecanoylphorbol Acetate; D005690:Galactose