Molecular mechanisms of radiation carcinogenesis and the linear, non-threshold dose response model of radiation risk estimation.
Recent research in molecular radiation carcinogenesis is reviewed with the specific aim of exploring the implications this research may have on the dose response relationship of radiation-induced cancer at low doses and low dose rates. It is concluded that the linear non-threshold dose response hypothesis may be used in radiation protection planning as a simple, convenient method to optimize procedures and regulations, but should not be mistaken as a stringent scientific conclusion directly derived from the present state of knowledge of the processes involved in radiation carcinogenesis.
Department of Radiation Biology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary & Westfield College, UK.
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KR
Trott
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Rosemann
D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D016147:Genes, Tumor Suppressor / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism*; D012641:Selection, Genetic