Levels of collagen degradation products (telopeptides) in the tear film of patients with keratoconus.
OBJECTIVE
Levels of collagen degradation products (telopeptides) in the tear film of patients with keratoconus were measured to study the release of telopeptides in the tears.


METHODS
Tear samples were collected from 26 keratoconus patients and 36 age-similar human control subjects. Levels of telopeptides were quantified and compared between the two groups.


RESULTS
The telopeptide level in tears from keratoconus patients was 2.5-fold higher than in tears from the control group. The telopeptide concentration was age-dependent in both groups. In tears from young people, telopeptide level was 2-fold higher than in tears from the older people.


CONCLUSIONS
The tear film of patients with keratoconus contains higher levels of telopeptides than those of control subjects. Determination of telopeptide levels in tears could be useful for the follow-up of keratoconus development in patients.
Laboratoire de Biochimie et de Biologie Moléculaire, Faculté de Médecine, Brest, France.
J H
JH
Abalain
H
H
Dossou
J
J
Colin
H H
HH
Floch
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D002648:Child; D003094:Collagen / Q000378:metabolism*; D024042:Collagen Type I; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism*; D012720:Severity of Illness Index; D013666:Tears / Q000378:metabolism*
D015415:Biomarkers; D024042:Collagen Type I; D005136:Eye Proteins; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C042434:tear proteins; D003094:Collagen