Induction of tumor cell differentiation.
It is proposed that cell proliferation with reduced individual cell growth (total protein accumulation) is necessary, but not sufficient, for cell differentiation. These conditions may facilitate transcription and accumulation of histones H1 and/or H1o relative to the core histones. This may have a critical role in cell differentiation.
Department of Biological Sciences, State University of New York at Buffalo 14260, USA.
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Flickinger
D002454:Cell Differentiation; D002455:Cell Division; D006657:Histones / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*
D006657:Histones