Meal fatty acid uptake in adipose tissue: gender effects in nonobese humans.
We tested for gender differences in dietary fatty acid metabolism in 12 nonobese men and 12 nonobese women using the meal fatty acid tracer/adipose tissue biopsy study design. In addition to determining body composition, measurements of regional adipose tissue lipoprotein lipase activity, blood flow, and fat cell size were performed to place the meal fatty acid kinetic studies in perspective. Twenty-four hours after ingesting the test meal, the concentration of meal fatty acids was greater (P < 0.05) in abdominal subcutaneous than in thigh adipose tissue in both men (0. 61 +/- 0.12 vs. 0.45 +/- 0.09 mg/g) and women (0.59 +/- 0.10 vs. 0. 43 +/- 0.05) but was not different between men and women. A greater percentage of dietary fat was stored in subcutaneous adipose tissue in women than in men (38 +/- 3 vs. 24 +/- 3%, respectively, P < 0. 05), and a greater portion of meal fatty acid disposal was unaccounted for in men. Significant gender differences in regional adipose tissue blood flow after meal ingestion were noted; the differences were in the direction that could support greater nutrient storage in lower body fat in women.
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.
S A
SA
Romanski
R M
RM
Nelson
M D
MD
Jensen
D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism*; D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D048429:Cell Size / Q000502:physiology; D004041:Dietary Fats / Q000378:metabolism / Q000493:pharmacokinetics*; D004734:Energy Metabolism / Q000502:physiology; D005227:Fatty Acids / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000378:metabolism; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D007328:Insulin; D014280:Triglycerides; D008071:Lipoprotein Lipase