Determination of the minor component bromhexine in cotrimoxazole-containing tablets by absorption spectrophotometry and partial least-squares (PLS-1) multivariate calibration.
The mucolitic bromhexine [N-(2-amino-3,5-dibromobenzyl)-N-methylcyclohexylamine] has been determined in cotrimoxazole-containing tablets by partial least-squares (PLS-1) multivariate of spectrophotometric calibration data in the spectral range 310-350 nm. In the studied commercial tablets, cotrimoxazole is present in large excess (ca. 100:1 in weight) with respect to bromhexine, and a high degree of spectral overlapping exists among bromhexine and cotrimoxazole components. However, the obtained recoveries are reasonably good with the presently discussed technique.
Ribone
M E
ME
Departamento de Química Analítica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina.
Pagani
A P
AP
Olivieri
A C
AC
D001964:Bromhexine / Q000032:analysis*; D002138:Calibration; D016018:Least-Squares Analysis; D013054:Spectrophotometry, Atomic / Q000379:methods*; D013607:Tablets / Q000032:analysis*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000032:analysis*
D013607:Tablets; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D001964:Bromhexine