Efficient synthesis of rhodamine conjugates through the 2'-position.
Reaction of substrates containing primary amines with rhodamine 2'-esters cleanly produces fluorescent rhodamine 2'-amide conjugates at ambient temperature. Only primary amines react with the esters under these conditions. Chemoselectivity can thus be achieved in substrates containing different types of amines.
Adamczyk
M
M
Department of Organic Chemistry, Abbott Laboratories, Abbott Park, IL 60064-6016, USA. maciej.adamczyk@abbott.com
Grote
J
J
D000577:Amides; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D004952:Esters; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D012235:Rhodamines / Q000138:chemical synthesis* / Q000737:chemistry; D018629:Spectrometry, Mass, Secondary Ion; D013329:Structure-Activity Relationship
D000577:Amides; D004952:Esters; D007202:Indicators and Reagents; D012235:Rhodamines