A patient with cyclic neutropenia complicated by severe persistent neutropenia successfully delivered a healthy baby.
We describe a 24-year-old pregnant woman complicated by cyclic neutropenia (CN), who was successfully treated with granulocyte-colony stimulating factor (G-CSF). Her white blood cell (WBC) and neutrophil count fluctuated from 2,600 to 4,600/microl, and 26 to 2,530/microl, respectively. The peak neutrophil count gradually decreased as pregnancy advanced, resulting in the disappearance of its cyclicity. At 39 weeks of pregnancy when the neutrophil count became 84/microl, the patient was started on G-CSF and her neutrophil count increased to 1,550/microl on the fourth day after delivery. She delivered a healthy baby without any complications at 39 weeks of pregnancy.
First Department of Internal Medicine, School of Medicine, The University of Tokushima.
T
T
Abe
H
H
Azuma
A
A
Watanabe
T
T
Shigekiyo
S
S
Endou
R
R
Pou
R
R
Fukui
K
K
Maeda
T
T
Aono
T
T
Matsumoto
D000328:Adult; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D009504:Neutrophils; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy; D011256:Pregnancy Outcome
D016179:Granulocyte Colony-Stimulating Factor