The ratio of striatal D1 to muscarinic receptors changes in aging rats housed in an enriched environment.
The enriched environment (EC) causes morphological plasticity in striatal cells that express D1 and D2 receptors. We used radioligand binding assays to examine whether EC produces plasticity in striatal receptor density and receptor density ratios. After 30 days of EC, 2-year-old rats had a higher ratio of D1 to muscarinic receptors in striatum relative to singly housed rats. Assays also showed trends for a greater ratio of D1 to cannabinoid receptors and a greater density of D1 receptors in striatum after EC. D2 receptor density was unaffected by the EC condition.
Anderson
B J
BJ
Department of Psychology, SUNY Stony Brook, Stony Brook, NY 11794-2500, USA. banderson@notes.cc.sunysb.edu
Gatley
S J
SJ
Rapp
D N
DN
Coburn-Litvak
P S
PS
Volkow
N D
ND
D000375:Aging / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D003342:Corpus Striatum / Q000737:chemistry / Q000378:metabolism*; D004777:Environment; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011916:Rats, Inbred F344; D043882:Receptors, Cannabinoid; D017447:Receptors, Dopamine D1 / Q000032:analysis / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000032:analysis / Q000378:metabolism; D011955:Receptors, Drug / Q000032:analysis / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000032:analysis / Q000378:metabolism*
D043882:Receptors, Cannabinoid; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D011955:Receptors, Drug; D011976:Receptors, Muscarinic