Improved 3D quantitative mapping of blood volume and endothelial permeability in brain tumors.
We describe a new method to allow simultaneous mapping of endothelial permeability and blood volume in intracranial lesions. The technique is based on a tumor leakage profile during the first pass (fp) of contrast bolus calculated from the time-dependent plasma-contrast concentration function (PCCF) in three-dimensional (3D) T1-weighted dynamic studies. The performance of the method has been evaluated by comparing results with those obtained from more conventional methods in patients with primary brain neoplasms. The new permeability maps (k(fp)) are visually compatible with those calculated using a conventional multicompartment model (k(tran)). Quantitatively, the new maps are free from overestimation of k(tran) due to first-pass effects. The new blood volume maps, which segment out the contamination of contrast leakage, agree closely with maps derived from susceptibility studies. The new method is fast, robust, and easy to perform. The method is suitable for use in clinical environments and is likely to be of benefit where longitudinal assessment of treatment response is required.
Division of Imaging Science and Biomedical Engineering, Stopford Medical School, University of Manchester, United Kingdom. kll@sv1.smb.man.ac.uk
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KL
Li
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Zhu
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J
Waterton
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Jackson
D001932:Brain Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D002199:Capillary Permeability; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000493:pharmacokinetics; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012039:Regional Blood Flow
D003287:Contrast Media; D019786:Gadolinium DTPA