Jejunal adenocarcinoma presenting as a primary ovarian carcinoma.
OBJECTIVE
The aim of this case report was to evaluate the impact of immunohistochemical markers in diagnosing the primary site of adenocarcinoma in the abdominopelvic region.


METHODS
Surgicopathologic data were obtained from laparotomy and necropsy. Paraffin-embedded tissue from the ovary and jejunum was stained with hematoxylin and eosin, as well as with immunohistochemical stains for cytokeratin 20 and cytokeratin 7.


RESULTS
A 53-year-old African American woman underwent an emergency laparotomy due to small bowel obstruction. During the operation, in addition to a complex adnexal mass as the cause of obstruction, a small solid jejunal tumor was also identified. Pathologic evaluation of the two sites demonstrated an infiltrating moderately to poorly differentiated adenocarcinoma with mucinous features. The malignant cells from both intestinal and ovarian sites showed immunoreactivity for cytokeratin 20 and revealed negative staining for cytokeratin 7. These results confirmed the diagnosis of intestinal primary with ovarian metastasis, which was initially misdiagnosed as an ovarian primary.


CONCLUSIONS
Given the potential difficulty in determining the primary site of these tumors, immunohistochemistry proved to be a useful tool in reaching the correct diagnosis.
Department of Pathology, Jacobi Medical Center, Bronx, New York 10461, USA.
G
G
Kilic
M
M
Abadi
D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D007415:Intestinal Obstruction / Q000209:etiology; D007580:Jejunal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000556:secondary
D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins