Calcifying fibrous pseudotumor involving the neck of a five-week-old infant. Presence of factor XIIIa in the lesional cells.
Calcifying fibrous pseudotumor is an uncommon lesion characterized by hyalinized collagen, psammomatous or dystrophic calcifications, and a predominantly lymphoplasmacytic infiltrate. Although the pathogenesis is unclear, a possible relationship with other inflammatory "pseudotumors" has been proposed. We describe the pathology of two right neck calcifying fibrous pseudotumors present in a five-week-old female infant. The masses had many of the pathologic features of calcifying fibrous pseudotumor. The presence of a florid, mixed infiltrate, and the occurrence of more than one lesion in the same patient, favor the proposal that calcifying fibrous pseudotumor may be a sclerosing end stage of inflammatory myofibroblastic tumor. However, the presence of a previously undescribed participation of Factor XIIIa-positive cells suggests that the tumor may be of dermal dendrocyte origin.
Department of Pathology, Children's Memorial Hospital, Northwestern University, Chicago, Illinois 60614, USA.
K A
KA
Hill
F
F
Gonzalez-Crussi
A
A
Omeroglu
P M
PM
Chou
D015415:Biomarkers / Q000032:analysis; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006104:Granuloma, Plasma Cell / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D009135:Muscular Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009334:Neck Muscles / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D011503:Transglutaminases / Q000378:metabolism*
D015415:Biomarkers; D011503:Transglutaminases