The decision to cancel a preimplantation genetic diagnosis cycle.
It has been suggested that a minimum number (six) of cumulus-oocyte complexes (COCs) should be retrieved for fertilization to offer enough chances to ensure a pregnancy after a preimplantation genetic diagnosis (PGD) procedure. Therefore a decision to cancel a PGD cycle should be adequately weighted to offer the patients the highest chances to obtain a pregnancy. We describe a case where, after retrieving only three COCs suitable for fertilization, a triplet pregnancy was obtained. This case suggests that, although low numbers of COCs can reduce the effectiveness of the PGD procedure, other factors are involved in its final result. Thus, the opportunity of routinely cancelling such cycles should be reconsidered. In addition, this is, to our knowledge, the first case where sex selection was carried out to prevent the birth of carriers of the abnormal gene, and not of affected offspring.
Santaló
J
J
Unitat de Biologia Cellular, Facultat de Ciències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. Josep.Santalo@uab.es
Grossmann
M
M
Giménez
C
C
Marina
F
F
Egozcue
J
J
Marina
S
S
Vidal
F
F
D000328:Adult; D003657:Decision Making; D004624:Embryo Transfer; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D030342:Genetic Diseases, Inborn / Q000517:prevention & control; D006679:HIV Seropositivity / Q000150:complications / Q000235:genetics; D006467:Hemophilia A / Q000235:genetics / Q000517:prevention & control; D019698:Hepatitis C, Chronic / Q000150:complications / Q000235:genetics; D006801:Humans; D008297:Male; D009865:Oocytes / Q000502:physiology; D006080:Ovarian Follicle / Q000166:cytology / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis; D012743:Sex Preselection; D014960:X Chromosome / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics