Acceleration by KW-5092 of intestinal motility associated with acetylcholine release in vivo.
Effect of KW-5092 ([1-[2-[[[5-(piperidinomethyl)-2-furanyl]methyl]amino]ethyl]-2- imidazolidinylidene]propanedinitrile fumarate) on intestinal motility and release of endogenous acetylcholine (ACh) were measured simultaneously in the small intestine of anesthetized dog using the in vivo microdialysis method. Intraarterial and intravenous administrations of KW-5092 accelerated the intestinal motility and increased dialysate ACh concentrations. These KW-5092-induced responses paralleled the increase in blood concentration of KW-5092. Thus, the acceleration of intestinal motility by KW-5092 was found in vivo to be associated with an increase in ACh release from the intestinal cholinergic neurons.
Department of Surgery II, Nagasaki University School of Medicine, Japan.
N
N
Makimoto
A
A
Yamazaki
H
H
Kobayashi
N
N
Kishibayashi
K
K
Ohmori
A
A
Furuichi
T
T
Kanematsu
K
K
Taniyama
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D009570:Nitriles / Q000494:pharmacology*
D005765:Gastrointestinal Agents; D007093:Imidazoles; D009570:Nitriles; C081341:KW 5092; D000109:Acetylcholine