Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to L-thyronine.
The synthesis of substituted phenoxyphenyl oxamic acid derivatives related to L-thyronine (L-T3) is described. The in vitro and in vivo cholesterol lowering and cardiovascular effects of these compounds are presented and discussed.
Metabolic and Cardiovascular Diseases Research, Novartis Institute for Biomedical Research, Summit, NJ 07901, USA. james.stanton@pharma.novartis.com
J L
JL
Stanton
E
E
Cahill
R
R
Dotson
J
J
Tan
H C
HC
Tomaselli
J M
JM
Wasvary
Z F
ZF
Stephan
R E
RE
Steele
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013970:Thyronines / Q000737:chemistry*
D000924:Anticholesteremic Agents; D002317:Cardiovascular Agents; D013970:Thyronines; D010072:Oxamic Acid