Rhenium-188-labeled anti-neural cell adhesion molecule antibodies with 2-iminothiolane modification for targeting small-cell lung cancer.
We have evaluated the potential of 188Re-labeled monoclonal antibodies (MAbs) modified with 2-iminothiolane (2IT) for targeting small-cell lung cancer (SCLC). Radiolabeled MAbs NK1NBL1 and C218 recognizing neural cell adhesion molecule were injected i.v. into athymic mice inoculated with human SCLC tumors, and the biodistribution was examined. NK1NBL1 localized in the tumors better than C218. 188Re-labeled MAbs cleared from the blood faster than 125I-labeled counterparts, resulting in higher tumor-to-blood ratios. In conclusion, the 188Re-labeled MAbs are attractive candidates for imaging and therapy of SCLC.
Hosono
M N
MN
Department of Radiology, Osaka City University, Japan.
Hosono
M
M
Mishra
A K
AK
Faivre-Chauvet
A
A
Gautherot
E
E
Barbet
J
J
Knapp
F F
FF
Chatal
J F
JF
D000818:Animals; D000911:Antibodies, Monoclonal; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging*; D003432:Cross-Linking Reagents; D006801:Humans; D007096:Imidoesters; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D051379:Mice; D008819:Mice, Nude; D019006:Neural Cell Adhesion Molecules / Q000276:immunology*; D016719:Radioimmunodetection / Q000379:methods; D011868:Radioisotopes / Q000493:pharmacokinetics*; D012211:Rhenium / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
D000911:Antibodies, Monoclonal; D003432:Cross-Linking Reagents; D007096:Imidoesters; D019006:Neural Cell Adhesion Molecules; D011868:Radioisotopes; C005905:methyl 4-mercaptobutyrimidate; D012211:Rhenium