Cell biology. Travel bulletin--traffic jams cause tumors.
All animal cells have a polarity, that is, different proteins are clustered in distinct domains of the plasma membrane and these regions carry out different jobs. As Peifer discusses in a lively Perspective, new work (Bilder et al.) identifies some of the molecular characters that direct proteins to their different cellular destinations.
Peifer
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Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. peifer@unc.edu
D000818:Animals; D001692:Biological Transport; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D002471:Cell Transformation, Neoplastic; D003593:Cytoplasm / Q000378:metabolism; D004330:Drosophila / Q000166:cytology / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007365:Intercellular Junctions / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D009154:Mutation; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D010641:Phenotype; D017434:Protein Structure, Tertiary; D025521:Tumor Suppressor Proteins
D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; C404683:Scrib protein, Drosophila; D025521:Tumor Suppressor Proteins; C081435:l(2)gl protein, Drosophila; C070350:dlg1 protein, Drosophila