[Drug therapy before and after surgery for epilepsy. Critical review and recommendations].
As a result of a critical review of the literature and a survey at German epilepsy centers of usual pre- and postoperative drug treatment, the following strategy is recommended: 1. Patients under consideration for surgery should be referred to specialists. Experience has shown that surgery is reasonable for only about a third of all patients with refractory epilepsies. The patient should first have been treated for at least 3 years with at least two first-line drugs in monotherapy and subsequent combined therapy. This applies only to medial temporal lobe epilepsies with very good postoperative prognoses. All other surgically removable epilepsy syndromes with less positive prognosis should be treated with additional antiepileptic drugs before any surgery. 2. There is no exception to the continuation of drug treatment after epilepsy surgery. If the patient remains free of seizures for at least 2 years, discontinuing the drug treatment can be discussed, just as with patients who are free of seizures due to drug treatment alone. In general, the less successful the operative therapy, the longer and more intensive the drug treatment.
Neurologische Klinik, Universität Erlangen-Nürnberg. zee@neuro.med.uni-erlangen.de
H
H
Stefan
W
W
Fröscher
G
G
Krämer
D
D
Schmidt
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D004361:Drug Tolerance; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery*; D005858:Germany; D019538:Health Care Surveys; D006801:Humans; D019635:Neurosurgical Procedures; D011182:Postoperative Care; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D011300:Preoperative Care
D000927:Anticonvulsants