The theoretical basis for scaling-up by the use of the method of microwave granulation.
For the scaling-up achieved by the use of the method of wet microwave granulation based on calculations, there is a need for an exact mathematical description for the relationship between the dose of radiation and the resultant effect. By assessing the physical, physical-chemical, and chemical factors, we may conclude that, by the gross kinetic evaluation of the change in the enthalpy and the loss of humidity, there is a possible solution for the mathematical description of the single-step, single-pot granulation from the practical aspect of finding ways to scale-up. This paper overviews the experiments performed in a laboratory-size microwave vacuum granulator in testing two different granules with respect to composition and permittivity and presents the evaluation of the experimental data.
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Meditop Pharmaceutical Co., Pilisborosjenõ.
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Acs
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Greskovits
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D019355:Calcium Citrate / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D004345:Drug Industry / Q000379:methods; D019277:Entropy; D005079:Excipients / Q000737:chemistry; D006813:Humidity; D007700:Kinetics; D007785:Lactose / Q000737:chemistry; D008872:Microwaves; D008956:Models, Chemical; D010316:Particle Size; D011208:Powders; D013678:Technology, Pharmaceutical / Q000379:methods*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D005079:Excipients; D011208:Powders; D014867:Water; D007785:Lactose; D019355:Calcium Citrate