Antitumor promoting activities of 3-O-acyl-(-)epigallocatechins.
As an exploratory investigation of antitumor promoting compounds, 3-O-acyl-(-)-epigallocatechins possessing a straight-, branched-, phenyl-inserted- or 1,4-phenylene-inserted-acyl chain of varying length from C4 to C18 were synthesized and evaluated their inhibitory effects against the activation of the Epstein-Barr virus early antigen (EBV-EA). It was indicated that the epigallocatechin derivatives having the straight- or branched-acyl chain of C8 to C11 carbon atoms achieve marked effects.
Uesato
S
S
Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, Osaka, Japan. uesato@ipcku.kansai-u.ac.jp
Kitagawa
Y
Y
Hara
Y
Y
Tokuda
H
H
Okuda
M
M
Mou
X Y
XY
Mukainaka
T
T
Nishino
H
H
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives*; D005419:Flavonoids / Q000494:pharmacology*; D004854:Herpesvirus 4, Human / Q000187:drug effects; D014775:Virus Activation / Q000187:drug effects
D016588:Anticarcinogenic Agents; D005419:Flavonoids; D002392:Catechin; C057580:gallocatechol