The effect of zhu yu hua tan tang on intracranial pressure in case of acute cerebral hemorrhage.
The therapeutic effect of Zhu Yu Hua Tan Tang ([symbol: see text] Decoction for removing blood stasis and resolving phlegm) plus general and modern treatment on acute cerebral hemorrhage in 44 cases, and the pressure-lowering effect of Zhu Yu Hua Tan Tang and mannitol in 20 cases of acute cerebral hemorrhage in the basilar region, and in rabbits with experimental encephaledema induced by injection of olive oil into the common carotid artery were observed in this study. The results showed that Zhu Yu Hua Tan Tang plus general treatment can better improved the conscious state of the patients than western medicine, and it can make the intracranial pressure drop clinically by 40.44%. The intracranial pressure-lowering effect of Zhu Yu Hua Tan Tang, though slow, is smooth and long-lasting without any rebound phenomenon, as compared to those of mannitol. Similar results were found in animal experiments, but the intracranial pressure-lowering amplitude of Zhu Yu Hua Tan Tang was stronger than that of mannitol. The difference between the clinical and experimental results needs to be further studied.
Guo
Z
Z
Shenzhen Municipal Hospital of Traditional Chinese Medicine, Guangdong Province.
Shi
S
S
Yang
W
W
Li
M
M
Zhang
F
F
D000368:Aged; D000818:Animals; D002543:Cerebral Hemorrhage / Q000188:drug therapy* / Q000503:physiopathology; D004234:Diuretics, Osmotic / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D008875:Middle Aged; D011817:Rabbits
D004234:Diuretics, Osmotic; D004365:Drugs, Chinese Herbal; D008353:Mannitol