[Adjuvant chemotherapy following radical surgery for non-small cell lung cancer: a randomized study].
OBJECTIVE
To evaluate the efficacy of adjuvant chemotherapy after radical surgery for non-small cell lung cancer (NSCLC).


METHODS
Seventy patients with NSCLC(stage I-III) undergone radical surgery were randomized into two groups: 35 patients received adjuvant chemotherapy with cyclophosphamide (CTX) 300 mg/m2, vincristine(VCR) 1.4 mg/m2, adriamycin(ADM) 50 mg/m2, d1; cisplatin (PDD) 20 mg/m2, d1-5, for 4 cycles, and followed by oral ftorafur (FT-207) 600-900 mg/d for 1 year (adjuvant chemotherapy group). The other 35 patients received surgical treatment only (surgery group).


RESULTS
The overall 5-year survival rate was 48.6% in the adjuvant chemotherapy group, and 31.4% in the surgery group, respectively. The difference between the two groups was not statistically significant (P > 0.05). The 5-year survival rate of patients in atage III was 44.0% and 20.8% (5/24) received surgery with and without adjuvant chemotherapy, respectively. The difference between the two groups was statistically significant (P < 0.025). The 5-year survival rate of patients in stage I-II in the two group was 60.0% and 54.5%, respectively (P > 0.75).


CONCLUSIONS
Postoperative adjuvant chemotherapy in NSCLC improves survival but only in patients in stage III, it results in significantly higher 5-year susvival rate than surgery alone.
Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou.
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Xu
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Rong
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Lin
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D015996:Survival Rate; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin