[Whole bladder wall laser irradiation to prevent bladder cancer recurrence with intravesical HpD and ascorbic acid].
OBJECTIVE
To evaluate the effect of whole bladder wall laser irradiation with intravesical HpD and ascorbic acid on bladder cancer recurrence.


METHODS
Photodynamic therapy(PDT) was performed by intravesical instillation of hematoporphyrin derivative (HpD) PsD-007 containing ascorbic acid followed by whole bladder wall laser irradiation in 30 post-operative cases of bladder cancer.


RESULTS
The tumour recurrence rate was 23.3% (7/30) on follow-up for 30 months after PDT. No photo-sensitizing effects was found on the skin of patients, nor was retraction of bladder observed in any case of this series.


CONCLUSIONS
This method is effective in the prevention of bladder cancer recurrence. Protection from light is not necessary during treatment.
Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
C
C
Li
Y
Y
Chen
Q
Q
Wang
D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy*; D005260:Female; D006414:Hematoporphyrin Photoradiation; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D006415:Hematoporphyrins; D011838:Radiation-Sensitizing Agents; C052552:photocarcinorin