Influence of auto-antibody specificities on the clinical course in patients with chronic and acute ITP.
It is now well established that the target antigens of platelet auto-antibodies are the GP IIb/IIIa and GP Ib/IX receptors. In our study, it was observed that the majority of patients had antibodies directed towards the GP IIb/IIIa receptor, whereas the number of patients having antibodies directed towards the GP Ib/IX receptor was much less. Also, we found that the patients in whom the auto-antibodies are directed towards the GP IIb/IIIa receptors usually have mild bleeding. On the other hand, the patients having auto-antibodies directed towards both GP IIb/IIIa and GP Ib/IX receptors have a severe bleeding diathesis, and usually show poor prognosis to treatment with corticosteroids.
Institute of Immunohaematology (ICMR), K.E.M. Hospital Campus, Parel, Mumbai, India. yasheshmehta@hotmail.com
Y S
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Mehta
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Pathare
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Badakere
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Ghosh
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Mohanty
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000918:Antibody Specificity / Q000276:immunology; D001323:Autoantibodies / Q000009:adverse effects / Q000097:blood / Q000276:immunology*; D016009:Chi-Square Distribution; D002648:Child; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D006470:Hemorrhage / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D015994:Incidence; D008297:Male; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000276:immunology; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000276:immunology; D011379:Prognosis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis* / Q000276:immunology*; D016896:Treatment Outcome
D001323:Autoantibodies; D007074:Immunoglobulin G; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex