[The diagnostic significance of the indices of oxygen-dependent neutrophil metabolism in rheumatism patients with a background of leukopenia].
Results are submitted of investigations designed to study parameters characterizing the peripheral blood neutrophil functional activity in leukopenias accompanying the course of rheumatism. Neutrophils were proved to be defective, their disturbed functional activity being manifested by the decrement of their ability to restore the NBT-test. There has been noted an inadequate augmentation of the metabolic activity following neutrophil stimulation as compared to results in healthy subjects. Of practical significance in the above investigations is screening of patients presenting with low values for the functional reserve of neutrophils as a threat to the early prediction of the course of pyo-inflammatory complications. It is suggested that a spontaneous NBT-test be used in the differential diagnosis of bacterial and non-bacterial complications while a stimulated NBT-test is believed to be helpful in identifying neutrophil dysfunction when results of a spontaneous NBT-test are at variance with clinical findings.
Matiukha
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D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007202:Indicators and Reagents; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000097:blood / Q000175:diagnosis*; D009504:Neutrophils / Q000378:metabolism*; D009580:Nitroblue Tetrazolium; D010100:Oxygen / Q000097:blood*; D012216:Rheumatic Diseases / Q000097:blood / Q000175:diagnosis*
D007202:Indicators and Reagents; D009580:Nitroblue Tetrazolium; D010100:Oxygen