Near infrared spectroscopy (NIRS) distinguishes seizure types.
Near infrared spectroscopy (NIRS) is a noninvasive method for bedside measurement of cerebral oxygenation (SaO(2)). The purpose of this study was to establish differences in SaO(2)for complex partial seizures (CPS) and rapidly secondarily generalized CPS (RCPS). We studied eight adults with medically refractory epilepsy undergoing evaluation for temporal lobectomy. We continually measured cerebral SaO(2)via a Somanetic Invos 3100a cerebral oximeter, pre-ictal (5 minutes), ictal, immediate (30 seconds) post-ictal, and late post-ictal (5 minutes after ictus). Seventeen seizures (12 CPS, four RCPS and one subclinical) were recorded in eight patients. The percentage change in cerebral SaO(2)from pre-ictal to ictal periods was derived. Cerebral SaO(2)increased (percentage change, mean: 16.6, SD: 13.9) for CPS and decreased (percentage change, mean: 51.1, SD: 18.1) for RCPS. No change in cerebral oximetry was recorded for the subclinical seizure. Post-ictal (immediate and late) increase in cerebral SaO(2)was seen for 11 of the 17 seizures (nine CPS and two RCPS). Peripheral SaO(2)rose greater than 93% for all CPS and the subclinical seizure, but decreased between 78 and 84% during RCPS. These results suggest NIRS distinguishes cerebral SaO(2)patterns between CPS and RCPS. The decrease in peripheral SaO(2), however, may account for the decrease in cerebral SaO(2)seen in generalized seizures.
Department of Neurology, Indiana University School of Medicine, Indianapolis, 46202, USA.
D K
DK
Sokol
O N
ON
Markand
E C
EC
Daly
T G
TG
Luerssen
M D
MD
Malkoff
D000328:Adult; D001785:Blood Gas Monitoring, Transcutaneous; D001921:Brain / Q000378:metabolism*; D003937:Diagnosis, Differential; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000378:metabolism; D017029:Epilepsy, Complex Partial / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D012720:Severity of Illness Index; D019265:Spectroscopy, Near-Infrared
D010100:Oxygen