Adult ovary transfer counteracts the callosal enlargement resulting from prepubertal ovariectomy.
The rat corpus callosum (CC) is larger in males than females, and is sensitive to hormone manipulations during development. Previous research found that, in rats, CC sensitivity to testosterone ended by postnatal day 8 (P8). In contrast, more recent findings demonstrated that CC responsivity to ovarian hormones continued at least through P70. The current experiment extends these findings by showing that the female callosum is still sensitive to ovarian hormones as late as P130, well into adulthood.
Biobehavioral Sciences Graduate Degree Program U-154, University of Connecticut, Storrs, CT 06269-4154, USA.
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Bimonte
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Holly Fitch
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Denenberg
D000704:Analysis of Variance; D000818:Animals; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000187:drug effects / Q000254:growth & development*; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D008297:Male; D010052:Ovariectomy; D010053:Ovary / Q000378:metabolism / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D014770:Virilism / Q000378:metabolism
D004967:Estrogens