A new cytotoxic polyhydroxysterol from soft coral Sarcophyton trocheliophorum.
A new cytotoxic polyhydroxysterol, 23,24-dimethylcholest-16(17)-E-en-3beta,5alpha,6beta,2 0(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC50 values of 2.8, 4.3, and 4.9 microg/ml, respectively, and exhibited minimal toxicity to normal human peripheral blood lymphocytes.
Bioscience Center. Department of Biological Science, Faculty of'Science, National University of Singapore, Singapore. dongh@cuhk.edu.hk
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D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002782:Cholestenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D014407:Tumor Cells, Cultured
C417464:23,24-dimethylcholest-16(17)-E-en-3beta,5alpha,6beta,20(S)-tetraol; D000970:Antineoplastic Agents; D002782:Cholestenes