[Idiopathic interstitial nephritis induced acute renal failure: clinical and pathological analysis].
OBJECTIVE
To understand idiopathic interstitial nephritis (IIN) and its relationship with acute renal failure as well as its clinical and pathological characteristics for avoiding misdiagnosis and missing diagnosis.


METHODS
A detail clinical and pathological analysis was performed on 7 patients with idiopathic interstitial nephritis.


RESULTS
The major manifestations were acute non-oliguric renal insufficiency combined with mild proteinuria (< 2 g/d), microscopic hematuria and obvious disorder of renal tubular function (for example, glycosuria). Three patients had high gamma-globulinemia and 2 were associated with uveitis. Renal biopsy showed typical tubulointerstial nephritis but glomeruli, and the renal vasculature was almost normal. All patients were treated with prednison. Renal function recovered in 5 patients.


CONCLUSIONS
When a patient has renal insufficiency especially non-oliguric renal failure with disorder of tubular function without definite causes, IIN should be considered. The diagnosis and treatment should be done immediately.
Department of Nephrology, First Hospital, Beijing Medical University.
Q
Q
Jin
Y
Y
Liu
Y
Y
Shen
D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D011241:Prednisone