Use of a platelet filter test in patients with thrombocytosis.
In the differential diagnosis of primary and secondary thrombocytosis platelet function tests may play an important role. We examined the applicability of a platelet filter test (shear-dependent platelet aggregation) as a tool, to differentiate primary thrombocytosis (cases with myeloproliferative disorders) from secondary (reactive) thrombocytosis. The test was carried out in 53 patients suffering from myeloproliferative disorders associated with primary thrombocytosis and in 21 patients with other diseases complicated by secondary thrombocytosis. Using citrate as anticoagulant, the sensitivity of the O'Brien's test proved to be 77.1%, and its specificity 94.4%. Using heparin as anticoagulant the sensitivity and specificity of the test were found to be also reliably high. Based on these studies we suggest the use of the O'Brien's filterometer as a screening test in the differential diagnosis in patients with elevated platelet count. In the case of normal results, the causes of reactive thrombocytosis should be clarified first, while with abnormal results, haematological examination of the patients should be performed.
2nd Department of Internal Medicine, University Medical School, Debrecen, Hungary.
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L
Rejtö
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A
Schlammadinger
P
P
László
A
A
Kiss
B
B
Telek
Z
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Boda
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000494:pharmacology; D001760:Bleeding Time; D002908:Chronic Disease; D019343:Citric Acid / Q000494:pharmacology; D003937:Diagnosis, Differential; D004837:Epinephrine / Q000494:pharmacology; D005189:False Positive Reactions; D005260:Female; D005374:Filtration; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood / Q000175:diagnosis; D015539:Platelet Activation; D010976:Platelet Count; D010979:Platelet Function Tests / Q000295:instrumentation / Q000379:methods*; D012680:Sensitivity and Specificity; D013922:Thrombocytosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D014841:von Willebrand Factor / Q000378:metabolism
D000925:Anticoagulants; D014841:von Willebrand Factor; D019343:Citric Acid; D000244:Adenosine Diphosphate; D006493:Heparin; D004837:Epinephrine