Time course of inwardly rectifying K(+) current reduction in glial cells surrounding ischemic brain lesions.
K(+) currents of activated glial cells surrounding ischemic infarcts are investigated using acutely dissociated cells from the periinfarct area after permanent middle cerebral artery occlusion in rats. Inwardly rectifying K(+) currents (K(IR)) were markedly reduced in cells neighboring infarcts with maximal alteration at day 3 after infarct followed by a partial recovery. This reduction of glial K(IR) currents may contribute to the functional disturbances in the periinfarct area.
Köller
H
H
Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, P.O. Box 101007, D-40001D-40225, Düsseldorf, Germany. koeller@neurologie.uni-duesseldorf.de
Schroeter
M
M
Jander
S
S
Stoll
G
G
Siebler
M
M
D000818:Animals; D001464:Barium / Q000494:pharmacology; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D002478:Cells, Cultured; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D020244:Infarction, Middle Cerebral Artery; D017136:Ion Transport / Q000187:drug effects / Q000502:physiology; D009414:Nerve Growth Factors; D009457:Neuroglia / Q000378:metabolism* / Q000473:pathology; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying; D051381:Rats; D017208:Rats, Wistar; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D009414:Nerve Growth Factors; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D001464:Barium; D011188:Potassium