Effect of single wrist exercise on fibroblast growth factor-2, insulin-like growth factor, and growth hormone.
Anabolic effects of exercise are mediated, in part, by fibroblast growth factor-2 (FGF-2), insulin-like growth factor-I (IGF-I), and growth hormone (GH). To identify local vs. systemic modification of these mediators, 10 male subjects performed 10 min of unilateral wrist-flexion exercise. Blood was sampled from catheters placed in basilic veins of both arms. Lactate was significantly increased only in the exercising arm. FGF-2 decreased dramatically (P < 0.01) in both the resting (from 1.49 +/- 0.32 to nadir at 0.11 +/- 0.11 pg/ml) and exercising arm (1.80 +/- 0.60 to 0.29 +/- 0.14 pg/ml). Small but significant increases were found in both the resting and exercising arm for IGF-I and IGF binding protein-3 (IGFBP-3). GH was elevated in blood sampled from both the resting (from 1.04 +/- 0.68 to a peak of 2.57 +/- 0.53 ng/ml) and exercising arm (1.04 +/- 0.66 to 2.43 +/- 0.42 ng/ml, P < 0.05). Unilateral wrist exercise was not sufficiently intense to increase circulating lactate or heart rate, but it led to systemic changes in GH, IGF-I, IGFBP-3, and FGF-2. Low-intensity exercise involving small muscle groups can influence the circulating levels of growth factors.
Department of Pediatrics, University of California, College of Medicine, Irvine 92868, USA.
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Eliakim
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Cooper
D000328:Adult; D002352:Carrier Proteins / Q000097:blood; D015444:Exercise / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006023:Glycoproteins / Q000097:blood; D006400:Hematocrit; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010447:Peptide Hydrolases / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism*; D014953:Wrist / Q000502:physiology*
D002352:Carrier Proteins; D006023:Glycoproteins; D018972:Insulin-Like Growth Factor Binding Protein 3; D013002:Somatomedins; C075944:insulin-like growth factor binding protein, acid labile subunit; D016222:Fibroblast Growth Factor 2; D019382:Human Growth Hormone; D019344:Lactic Acid; D007334:Insulin-Like Growth Factor I; D010447:Peptide Hydrolases