[The predominant expression of Th2 type cytokines in human tumor cells].
OBJECTIVE
To observe the expression of Th1 versus Th2 type cytokines in human tumor cells.


METHODS
The gene expression of Th1/Th2 cytokines in human tumor cells was detected by RT-PCR and RNA dot hybridization using IL-2 and IFN gamma as Th1 type cytokine genes, IL-4, IL-10 and IL-13 as Th2 type cytokine genes.


RESULTS
There were predominant expressions of Th2 type cytokines in 20 different human tumor cell lines including 11 solid tumor and 9 hematogenous tumor cells.


CONCLUSIONS
Predominant expression of Th2 type cytokines by tumor cells may be related to the evasion of tumor cells from immune surveillance.
Liu
J
J
Shandong Cancer Biotherapy Center, Shandong Academy of Medical Sciences, Jinan.
Tian
Z
Z
Sun
R
R
D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D018793:Interleukin-13 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology; D008223:Lymphoma / Q000378:metabolism / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000378:metabolism*
D016207:Cytokines; D018793:Interleukin-13; D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma