Intrapericardiac injections of algogenic chemicals excite primate C1-C2 spinothalamic tract neurons.
Extracellular potentials of 38 C1-C2 spinothalamic tract (STT) neurons in anesthetized monkeys (Macaca fascicularis) were examined for responses to intrapericardiac injections of an algogenic chemical mixture (adenosine, 10(-3) M; bradykinin, prostaglandin E(2), serotonin, histamine, each 10(-5) M). Chemical stimulation of cardiac/pericardiac receptors increased activity of 21 cells, decreased activity of 5 cells, and did not change activity of 12 cells. Cells excited by chemical stimuli received input from noxious mechanical stimulation of somatic fields; most receptive fields included the neck, inferior jaw, or head areas. Nerve ablations in 11 cells excited by intrapericardiac chemicals showed that cardiac input activated by algogenic chemicals traveled primarily in vagal afferent fibers to C1-C2 segments; phrenic or cardiopulmonary sympathetic inputs were predominant in 2 of 11 cells. These results supported the concept that activation of cardiac vagal afferents might lead to the production of referred pain sensation in somatic fields innervated from high cervical segments.
Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA. margaret-chandler@ouhsc.edu
M J
MJ
Chandler
J
J
Zhang
C
C
Qin
Y
Y
Yuan
R D
RD
Foreman
D000344:Afferent Pathways / Q000503:physiopathology; D000818:Animals; D004338:Drug Combinations; D004594:Electrophysiology; D006329:Heart Conduction System / Q000503:physiopathology; D007267:Injections; D008168:Lung / Q000294:innervation; D008252:Macaca fascicularis; D008297:Male; D009333:Neck; D009474:Neurons / Q000502:physiology*; D009619:Nociceptors / Q000503:physiopathology; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D010496:Pericardium / Q000503:physiopathology*; D010791:Phrenic Nerve / Q000503:physiopathology; D010812:Physical Stimulation; D013133:Spinothalamic Tracts / Q000473:pathology / Q000503:physiopathology*; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014630:Vagus Nerve / Q000503:physiopathology
D004338:Drug Combinations