Roles of phospholipid signaling in chemoattractant-induced responses.
Chemoattractants, including chemokines, play a central role in regulation of inflammatory reactions by attracting and activating leukocytes. These molecules have been found to regulate metabolism of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) via phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K). Recent studies of mouse lines that lack PLC-(beta)2, PLC-(beta)3, or PI3K(gamma) demonstrate that chemoattractants act through PLC-(beta)2 and PLC-(beta)3 to hydrolyze PtdIns(4,5)P(2) and through PI3K(gamma) to phosphorylate PtdIns(4,5)P(2) in mouse neutrophils. These studies also confirmed the importance and revealed new roles of these signaling pathways in chemoattractant-induced responses.
Department of Genetics and Developmental Biology and Department of Pathology, University of Connecticut, Farmington, CT 06030, USA.
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D000818:Animals; D018925:Chemokines / Q000502:physiology; D002630:Chemotactic Factors / Q000502:physiology*; D002633:Chemotaxis; D019204:GTP-Binding Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000502:physiology*; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D015398:Signal Transduction; D013481:Superoxides / Q000378:metabolism; D010738:Type C Phospholipases / Q000235:genetics / Q000502:physiology*
D018925:Chemokines; D002630:Chemotactic Factors; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; C060974:phosphatidylinositol 3,4,5-triphosphate; D013481:Superoxides; D019869:Phosphatidylinositol 3-Kinases; D010738:Type C Phospholipases; D019204:GTP-Binding Proteins