Primary anaplastic large cell lymphoma of the adrenal gland.
Primary adrenal lymphomas are rare. Most reported cases are of B-cell phenotype and follow an aggressive clinical course. We report a case of primary anaplastic large cell, CD30+ adrenal lymphoma developing in a 62-year-old woman. The patient presented with fatigue and vague right upper quadrant pressure. Computed tomography revealed bilateral adrenal masses. A right adrenalectomy was performed. Histologic evaluation showed islands of large atypical cells surrounded by eosinophilic acellular material. The tumor cells stained positive for CD45, CD45RO, CD43, and CD30. Epstein-Barr virus genome was identified in tumor cells using in situ hybridization. The patient was treated with chemotherapy and a 23-month follow-up examination showed no change in the size of the opposite adrenal gland and no other evidence of lymphoma.
Department of Pathology, The Ohio State University Medical Center and Arthur G. James Cancer Hospital and Research Institute, Columbus, USA.
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WL
Frankel
P
P
Shapiro
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N
Weidner
D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D000315:Adrenalectomy; D015703:Antigens, CD; D003131:Combined Modality Therapy; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D017493:Leukocyte Common Antigens / Q000032:analysis; D051917:Leukosialin; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008875:Middle Aged; D012795:Sialoglycoproteins / Q000032:analysis
D015703:Antigens, CD; D017730:Ki-1 Antigen; D051917:Leukosialin; C465014:SPN protein, human; D012795:Sialoglycoproteins; D017493:Leukocyte Common Antigens