[Serotonin syndrome secondary to the use of sertraline and metoclopramide].
The authors report the case of a patient who developed a serotonin syndrome after taking sertraline and metoclopramide. The symptoms included malaise, cardiac arrhythmia, sudation, hyperreflexia, sialosis, diarrhea and were improved by cyproheptadine. The authors review the physiological bases of the serotonin syndrome, its incidence, clinical manifestations and treatment.
Service de Médecine Interne, Hôpital Erasme, U.L.B.
X
X
Vandemergel
I
I
Beukinga
P
P
Nève
D000328:Adult; D000932:Antiemetics / Q000009:adverse effects*; D003533:Cyproheptadine / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects*; D012702:Serotonin Antagonists / Q000627:therapeutic use; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D020280:Sertraline / Q000009:adverse effects*
D000932:Antiemetics; D003533:Cyproheptadine; D004338:Drug Combinations; D008787:Metoclopramide; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline