Fatal acute alcohol intoxication in an ALDH2 heterozygote: a case report.
On an evening in November, a 25-year-old man was found dead in his bedroom. There were many empty snap-out sheets for flunitrazepam tablets in the trash at his bedside. He had been beaten by a gang of young people earlier in the morning of the same day. At the medico-legal autopsy, although there were many bruises and/or abrasions on the whole body, only slight subdural hemorrhage was observed, and none of them was thought to be the cause of death. Flunitrazepam and its metabolites were not detected in his body fluid by gas chromatography-mass spectrometry (GC-MS). Marked lung edema and a severe congestion of organs were observed. His blood alcohol concentration from the femoral vein was 2.00 mg/ml. Fatal cases of acute alcohol intoxication usually have shown higher alcohol concentration (2.25-6.23 mg/ml). Although the genotype of aldehyde dehydrogenase 2 (ALDH2) has not previously been mentioned as a contributing factor in determining the cause of death, in this case the genotype of ALDH2 was ALDH2*1/2 and thus is important. Those who possess the ALDH2*2 gene show high concentrations of acetaldehyde (AcH) at even comparatively lower alcohol levels. Consequently, the cause of death was considered to be acute alcohol intoxication including AcH poisoning.
Department of Forensic Medicine and Sciences, Mie University School of Medicine, 2-174, Edobashi, Tsu, 514-8507, Mie, Japan. yamachan@doc.medic.mie-u.ac.jp
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Yamamoto
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Tanegashima
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Hosoe
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Fukunaga
D000079:Acetaldehyde / Q000032:analysis / Q000506:poisoning; D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood / Q000150:complications*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D014151:Anti-Anxiety Agents / Q000032:analysis; D001826:Body Fluids / Q000737:chemistry; D002423:Cause of Death; D000431:Ethanol / Q000097:blood / Q000506:poisoning*; D017809:Fatal Outcome; D005445:Flunitrazepam / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D011654:Pulmonary Edema / Q000209:etiology
D014151:Anti-Anxiety Agents; D000431:Ethanol; D005445:Flunitrazepam; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000079:Acetaldehyde