Prediction of drug solubility in ternary solvent mixture.
Applicability of the combined, nearly ideal, binary solvent/Redlich-Kister equation for calculating drug solubility in ternary mixtures is presented. The advantages of the proposed model are discussed and compared with a recently published equation that calculates the solute solubility in ternary solvent mixtures based on the mixture response methodology.
Jouyban-Gharamaleki
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A
Drug Design Group, School of Pharmacy, University of Bradford, UK.
Clark
B J
BJ
Acree
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WE
D002626:Chemistry, Pharmaceutical; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D012997:Solvents
D004364:Pharmaceutical Preparations; D012997:Solvents