[Tropoxin and cerebrovascular effects of serotonin].
The effect of serotonin on the brain blood supply was studied in rats before and after ischemic damage. The ischemic damage, induced by ligation of the middle meningeal artery, markedly enhanced the constrictor effect of serotonin on the brain vessels. Tropoxin, a 5HT2 receptor blocker, completely eliminated these cerebrovascular effects of serotonin.
Laboratory of Cerebrovascular Disorder Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
R S
RS
Mirzoian
A V
AV
Topchian
T S
TS
Gan'shina
L M
LM
Kostochka
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000150:complications; D001372:Aza Compounds / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003251:Constriction, Pathologic / Q000150:complications; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000503:physiopathology; D020768:Middle Cerebral Artery; D051381:Rats; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
C114333:3-(3,4,5-trimethoxybenzoyloximino)-8-methyl-8-azabicyclo(3,2,1)octane; D001372:Aza Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D012702:Serotonin Antagonists; D014662:Vasoconstrictor Agents; D012701:Serotonin