[Geneotic analysis of wild type measles viruses circulating in China during 1995-1997].
To investigate the molecular epidemiology of measles virus (MV) in China, sequence analysis of MV was performed based on a 282-nt region of the nucleoprotein (N) gene and a 450-nt region of heamaglutinin (H) gene by direct sequencing of RT-PCR amplicons obtained from clinical specimens. Results revealed that one MV strain belonged to ED-like genotype and remainder strains were clustered into a new genotype which was distinct from Chinese vaccine strains and MV strains circulating in other countries, as previously described representing a new genotype. There was up to 15.4% divergence in the nt-282 N gene and 10.8% divergence in the nt-450 H gene between the new genotype and other genotypes.
Liaoning Provincial Anti-Epidemic and Health Station Shenyang, China.
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Sun
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Li
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Ge
D002681:China / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D008457:Measles / Q000453:epidemiology / Q000821:virology*; D008459:Measles virus / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA
D012367:RNA, Viral