Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems.
This review is focused on the most recent knowledge on growth control of rat thyroid cell lines. We analyzed the effect of mitogenic as well as inhibitory agents, but mainly the proliferative effect elicited by thyrotropin (TSH). The classic cAMP-dependent protein kinase (PKA) signal transduction pathway involved in TSH-mediated cell growth is analyzed exhaustively. We have also reviewed new concepts about the participation of other effectors such as small GTPases and phosphatidyl inositol-3-kinase (PI3-K) and the new data about the existence of a cAMP-dependent but PKA-independent pathway. Finally, we give information about TSH induction of cell cycle-related genes, such as G1 cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors.
Medina
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Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas y Universidad Autónoma de Madrid, Arturo Duperier 4, E-28029 Madrid, Spain.
Santisteban
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D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D016213:Cyclins / Q000235:genetics; D020558:GTP Phosphohydrolases; D015870:Gene Expression / Q000187:drug effects; D051381:Rats; D015398:Signal Transduction; D013961:Thyroid Gland / Q000166:cytology*; D013972:Thyrotropin / Q000494:pharmacology*; D018631:ras Proteins
D016213:Cyclins; D013972:Thyrotropin; D017868:Cyclic AMP-Dependent Protein Kinases; D020558:GTP Phosphohydrolases; D018631:ras Proteins