Protective effect of isoflavone derivative against photocarcinogenesis in a mouse model.
Plant-derived isoflavones are currently receiving much attention because of their phyto-estrogenic and antioxidant activities. In this study, we describe novel photoprotective effects of one isoflavone derivative from red clover (NV07), following its application topically in Skh:HR-1 hairless mice. We found that in mice irradiated in the short-term (3 days) with minimally erythemal solar simulated UV radiation, topical lotions containing NV07 dose-responsively reduced the erythema-associated oedema, the induction of ornithine decarboxylase, and the suppression of contact hypersensitivity. In mice irradiated chronically (50 days), daily application of topical NV07-lotion reduced photocarcinogenesis significantly, and appeared to be actively protective during both the initiation phase and the later promotion phase of tumour induction.
Department of Veterinary Anatomy and Pathology, University of Sydney, New South Wales, Australia.
S
S
Widyarini
N
N
Spinks
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VE
Reeve
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000209:etiology; D007887:Fabaceae; D005260:Female; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D009824:Ointments; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010946:Plants, Medicinal; D012867:Skin / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control*; D014466:Ultraviolet Rays
D016588:Anticarcinogenic Agents; D007529:Isoflavones; D009824:Ointments; D009955:Ornithine Decarboxylase