Radiation-induced apoptosis.
Radiation-induced apoptosis has been a topic of intense research during the last decade. Its recognition as a significant component of radiation-induced cell death has initiated several lines of investigation aimed at modulating the apoptotic response and thereby radiosensitivity. These strategies require the integration of both classical radiobiological concepts and the knowledge of the biochemical and molecular biological mechanisms involved in apoptosis induction. This review discusses mechanisms of radiation-induced apoptosis and highlights the radiobiological and radiotherapeutical relevance of this mode of cell death.
Department of Radiation Oncology, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Ziekenhuis, Amsterdam, The Netherlands. vhe@nki.nl
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D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D020169:Caspases / Q000502:physiology; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D008938:Mitosis / Q000528:radiation effects; D009369:Neoplasms / Q000532:radiotherapy; D015398:Signal Transduction / Q000528:radiation effects; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D016159:Tumor Suppressor Protein p53; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D020169:Caspases