Application of infrared spectrophotometry to the identification of inorganic substances in dosage forms of Antacida group.
Powdered tablets from the Antacida group: Alusal, Milk of Magnesia, Alumag, Maalox, Magnosil, Alugastrin, Malugastrin, Rennie, and components deciding about their antiacidity like Al(OH)3, Mg(OH)2, Mg2Si3O8, NaAl(OH)2CO3, MgAl(OH)(SO4)2, CaCO3, MgCO3, were subjected to infrared spectrophotometric investigations. It was found that infrared spectra of each pharmaceutical compound are different and show a series of characteristic maxima, by which they can be identified with in the spectral range of 4000 cm-1-200 cm-1. Comparison of infrared spectra of finished products with spectra of their components it was showed that the application of infrared spectrophotometry methods enabled us to prove the presence of particular compounds used in formulations. Tablet mass and odorizing agents do not cause significant changes in spectra of the tablets studied, preparations from the Antacida group.
Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
M H
MH
Umbreit
A
A
Jedrasiewicz
D000863:Antacids / Q000032:analysis*; D013055:Spectrophotometry, Infrared; D013607:Tablets
D000863:Antacids; D013607:Tablets