[Bcl-2 gene expression in endometrial carcinoma].
OBJECTIVE
To evaluate the relationship between bcl-2 gene and endometrial carcinoma.


METHODS
Immunohistochemical staining was performed on formalin-fixed paraffin-embedded tissue sections. A monoclonal antibody to the bcl-2 gene product was used, the signal was detected using a streptavidin-biotin complex with aminoethylcarbazole. There were 15 cases of endometrial atypical hyperplasia and 50 cases of endometrial carcinoma examined.


RESULTS
Bcl-2 expression was high in endometrial atypical hyperplasia, whereas bcl-2 expression was low in endometrial carcinoma. In endometrial carcinoma, with progression of clinical stage, decreased histologic grade and deepening of cancer invasion, the positive rate of bcl-2 expression was correspondingly decreased.


CONCLUSIONS
Bcl-2 plays a role in the genesis of endometrial carcinoma especially at the initial stage.
First Clinical College, China Medical University, Shenyang.
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Sheng
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Song
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He
D000328:Adult; D000368:Aged; D017209:Apoptosis; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015870:Gene Expression; D019254:Genes, bcl-2; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis
D019253:Proto-Oncogene Proteins c-bcl-2