Palladium-catalyzed intramolecular coupling of vinyl halides and ketone enolates. Synthesis Of bridged azabicyclic compounds
The palladium-mediated intramolecular coupling of amino-tethered vinyl halides and ketone enolates is a useful methodology for the synthesis of nitrogen heterocycles and constitutes a new synthetic entry to the 2-azabicyclo[3.3.1]nonane framework. A study about the reaction conditions and the scope of the process is reported.
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain.
D
Sole
E
Peidro
J
Bonjoch