[Depression of serum pyridoxal levels in theophylline-related seizures].
In order to study whether a theophylline-related seizure is caused by a decrease in serum vitamin B6, serum pyridoxal (PAL) levels were measured in children with bronchial asthma treated with theophylline. The serum PAL levels of asthmatic children (n = 31) treated with theophylline were significantly lower than those of control subjects (n = 21). Moreover, we evaluated PAL levels in four subjects within twenty-four hours after a seizure with or without fever. The level was low in three of the four. These results suggest that the decrease in PAL levels caused by theophylline may lower the seizure threshold.
Department of Pediatrics, Osaka City University Medical School.
T
T
Seto
H
H
Inada
N
N
Kobayashi
H
H
Tada
K
K
Furukawa
K
K
Hayashi
H
H
Hattori
O
O
Matsuoka
G
G
Isshiki
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008297:Male; D011730:Pyridoxal / Q000097:blood*; D012640:Seizures / Q000139:chemically induced*; D013806:Theophylline / Q000009:adverse effects*; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced* / Q000175:diagnosis
D015415:Biomarkers; D011730:Pyridoxal; D013806:Theophylline