Intimate details of the most poisonous poison.
Crystal structures of type B botulinum neurotoxin, determined under conditions relevant to the extracellular binding and intracellular substrate cleavage steps of its toxic action, reveal that minimal structural changes occur upon binding a ganglioside or after substrate cleavage. The unique structure of this toxin provides information for developing preventive measures against botulism.
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B R
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D001692:Biological Transport; D001905:Botulinum Toxins / Q000737:chemistry* / Q000378:metabolism*; D019274:Botulinum Toxins, Type A; D002462:Cell Membrane / Q000378:metabolism; D003014:Clostridium botulinum / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005732:Gangliosides / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins
D005732:Gangliosides; D008565:Membrane Proteins; D050600:SNARE Proteins; D033921:Vesicular Transport Proteins; C096323:rimabotulinumtoxinB; D001905:Botulinum Toxins; D019274:Botulinum Toxins, Type A