Effects of age, gender, and lifestyle factors on plasma apolipoprotein A-IV concentrations.
Apolipoprotein (apo) A-IV is a protein component of triglyceride (TG)-rich lipoproteins and high density lipoproteins (HDL). Plasma apo A-IV levels were measured by immunoelectrophoresis and these values were related to other biological variables in 723 middle aged and elderly men and women (more than 90% of them were Caucasian) prior to participation in a lifestyle modification program. Apo A-IV may play an important function in regulating lipid absorption, reverse cholesterol transport, and food intake. The data are consistent with the following concepts: (1) apo A-IV levels are significantly and positively correlated with age (r = 0.159, P < 0.05) in all subjects, with plasma apo A-I levels in both men (r = 0.194, P < 0.001) and women (r = 0.213, P < 0.001), and with apo E (r=0.111, P<0.05) and TG levels (r =0.120, P <0.05) in men; (2) apo A-IV levels are inversely correlated with body mass index (r = 0.170, P <0.05) in women; (3) female subjects on hormone replacement therapy have significantly lower plasma apo A-IV levels (by 4.1%, P < 0.05) than normal controls; (4) diabetic subjects have significantly higher apo A-IV levels (by 21%, P < 0.01) than normal subjects; (5) there is no significant effect of smoking, alcohol intake, and apo A-IV-1/2 genotype on apo A-IV levels. The data indicate that plasma apo A-IV levels are significantly affected by age, diabetes, and hormone replacement therapy.
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
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Sun
I A
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Larson
J M
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Ordovas
J R
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Barnard
E J
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Schaefer
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D001054:Apolipoproteins A / Q000097:blood*; D001057:Apolipoproteins E / Q000097:blood; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood
D001054:Apolipoproteins A; D001057:Apolipoproteins E; D014280:Triglycerides; C022205:apolipoprotein A-IV