Recurrent triploidy of maternal origin.
We report the occurrence of triploid preimplantation embryos following in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in a woman with two previously-identified triploid conceptuses which spontaneously underwent fetal demise at 10 and 23 weeks' gestation. An error in maternal meiosis II is proposed as the most likely cause.
Pergament
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E
Reproductive Genetics and Reproductive Endocrinology, Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL, USA. epergame@nmh.org
Confino
E
E
Zhang
J X
JX
Roscetti
L
L
Xien Chen
P
P
Wellman
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D
D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D001755:Blastocyst / Q000502:physiology; D003582:Cytogenetics; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008540:Meiosis; D009630:Nondisjunction, Genetic; D009866:Oogenesis / Q000235:genetics*; D011123:Polyploidy; D011247:Pregnancy; D019836:Preimplantation Diagnosis