Studies on the novel anti-staphyloccal compound nematophin.
A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active.
Kennedy
G
G
Medicines Research Centre, Glaxo Wellcome SpA, Verona, Italy. gk27184@glaxowellcome.co.uk
Viziano
M
M
Winders
J A
JA
Cavallini
P
P
Gevi
M
M
Micheli
F
F
Rodegher
P
P
Seneci
P
P
Zumerle
A
A
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007211:Indoles; C109330:nematophin