Small peptides Do not inhibit human non-pancreatic secretory phospholipase-A(2) (Type IIA).
Seven small peptides, that are among the most potent reported inhibitors of secreted mammalian phospholipases A(2), were found not to inhibit processing of a small phospholipid substrate by human non-pancreatic secretory phospholipase A(2) (type IIa), under conditions where certain non-peptides are potent inhibitors at nanomolar concentrations.
Clark
C I
CI
The Centre for Drug Design and Development, Institute for Molecular Bioscience, Brisbane, Queensland, 4072, Australia. c.clark@mailbox.up.edu.au
Reid
R C
RC
McGeary
R P
RP
Schafer
K
K
Fairlie
D P
DP
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D013379:Substrate Specificity
D004791:Enzyme Inhibitors; D010455:Peptides; D010741:Phospholipases A