Effects of streptozotocin-induced diabetes and pentylenetetrazol-induced seizure on brain cortex (Ca2+)ATPase activity in rats.
The aim of the present study was to obtain information about the effects of pentylenetetrazol-induced status epilepticus (SE) and streptozotocin-induced diabetes on brain cortex Ca(2+)ATPase activity. Treatment with pentylenetetrazol (PTZ) and streptozotocin (STZ) to rats resulted in significant decrease in brain cortex Ca(2+)ATPase activity as compared with controls. However, PTZ-treated diabetic rats had a slight but non-significant decrease in enzyme activity. Treatment with PTZ caused a more pronounced effect in inhibiting enzyme activity than that of treatment with STZ. Our results concluded that reduced brain cortex Ca(2+)ATPase activity following PTZ and STZ treatments to rats, may be an initial biochemical lesion which triggers a sequence of events which may culminate in cell death.
Department of Biochemistry, Istanbul Faculty of Medicine, University of Istanbul, Capa, Turkey.
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P
Oner
H
H
Koçak
B
B
Oztaş
D000818:Animals; D000903:Antibiotics, Antineoplastic; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002540:Cerebral Cortex / Q000201:enzymology* / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D018756:GABA Antagonists; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism; D013226:Status Epilepticus / Q000139:chemically induced / Q000378:metabolism*; D013311:Streptozocin
D000903:Antibiotics, Antineoplastic; D018756:GABA Antagonists; D013311:Streptozocin; D000252:Calcium-Transporting ATPases; D010433:Pentylenetetrazole