A case of toxic epidermal necrolysis-type drug eruption induced by oral lysozyme chloride.
We report a case of toxic epidermal necrolysis-type drug eruption. A 23-year-old man took an oral over-the-counter preparation for the common cold. A few days later, generalized erythema developed with systemic malaise and pain. A multiple blister formation followed, and Nikolsky's sign was noted on each blister. A lymphocyte stimulation test (LST) with the patient's peripheral lymphocytes strongly suggested that the eruption was attributable to lysozyme chloride which was included in the preparation taken. Following an intravenous drip of betamethasone for two weeks, the eruptions improved favorably.
Kobayashi
M
M
Department of Dermatology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yamamoto
O
O
Yasuda
H
H
Asahi
M
M
D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D000284:Administration, Oral; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D001623:Betamethasone / Q000008:administration & dosage; D001707:Biopsy, Needle; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects*; D003139:Common Cold / Q000188:drug therapy*; D004338:Drug Combinations; D005500:Follow-Up Studies; D006139:Guaiacol / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009113:Muramidase / Q000008:administration & dosage / Q000009:adverse effects*; D004366:Nonprescription Drugs / Q000008:administration & dosage / Q000009:adverse effects; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D014581:Urticaria / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D004366:Nonprescription Drugs; C413126:Shin Ruru A; D000082:Acetaminophen; D002110:Caffeine; D006139:Guaiacol; D001623:Betamethasone; D009113:Muramidase