[Esophageal carcinoma in part of population of Yangquan City].
OBJECTIVE
To evaluate the contribution of genetic factors to the occurrence of esophageal carcinoma (EC).


METHODS
A genetic epidemiology survey of one-tenth of the whole population (130,000 people) was conducted in 6 towns of Yangquan City, Shanxi province in 1994. 228 high-risk (EC) families were matched with equal number of control families.


RESULTS
The heritability of EC among first grade blood relatives was 52.6%, that among second grade blood relatives was 31.2%, and the summing up powered heritability was 49.2%. the segregation ratio was 18 +/- 3%, far less than 25%, suggesting a multi-gene effect. The distribution of EC in families did not fit well the binomial distribution, suggesting familial aggregation. The relative risk among male first grade blood relatives was 10.49, female was 7.69, in sum was 9.17. The attributive risks (AR) among first grade blood relatives were 62.13/100,000(male), 99.14/100,000(female) and 75.15/100,000(total). All of these figures were higher than the average (40.17/100,000).


CONCLUSIONS
Genetic factors plays important roles in occurrence of EC in the Taihang mountain region.
Li
W
W
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
Wang
X
X
Zhang
C
C
D000368:Aged; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence