Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer.
BRCA1/2 mutation carriers diagnosed with breast cancer have a strongly elevated life-time risk of developing a contralateral tumour. We studied the contralateral breast cancer risk in 164 patients from 83 families with a proven BRCA1 mutation in relation to the age at diagnosis of the first primary breast cancer. In the actuarial outcomes after 10 years' follow-up, 40% of the 124 BRCA1-patients diagnosed with breast cancer < 50 years had developed contralateral breast cancer, vs 12% of the 40 patients > 50 years at first diagnosis (Plogrank = 0.02). These data suggest that age at diagnosis of the first tumour should be taken into account when prophylactic mastectomy in BRCA1-patients is considered.
Family Cancer Clinic, Department of Medical Oncology, Daniel den Hoed Cancer Centre, University Hospital Rotterdam, The Netherlands.
L C
LC
Verhoog
C T
CT
Brekelmans
C
C
Seynaeve
E J
EJ
Meijers-Heijboer
J G
JG
Klijn
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics / Q000401:mortality; D005260:Female; D019398:Genes, BRCA1 / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000453:epidemiology; D009426:Netherlands / Q000453:epidemiology; D012306:Risk; D012307:Risk Factors; D015996:Survival Rate