[Circulating ICAM-1 in sera of renal allograft recipients in monitoring of acute rejection].
OBJECTIVE
To study the significance of ICAM-1 in sera of renal allograft recipients in mornitoring of acute rejection.


METHODS
The levels of circulating intercellular adhesion molecule-1 (cICAM-1) in sera of 87 renal transplantation recipients, including 29 patients with acute rejection and 8 patients with cyclosprine nephrotoxicity were measured by sandwich-ELISA.


RESULTS
The levels of cICAM-1 were elevated transiently after transplantation. They decreased and reached normal levels within 2 weeks. In the acute rejection episode, the levels of cICAM-1 were significantly higher than those of patients with stable graft function and cyclosporine nephrotoxicity (P < 0.001). The increase of cICAM-1 was seen 1-3 days early than the diagnosis was made. On successful antirejection therapy, the levels of cICAM-1 decreased to normal, but in patients with steroid-resistant rejection, it did not decrease.


CONCLUSIONS
The cICAM-1 in sera can be used to estimate the graft function, and it is also useful in prediction and differential diagnosis of acute rejection and prognosis.
Norman Bethune University of Medical Sciences, Urology Department, Changchun.
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Y
Fu
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M
Wang
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Ji
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006084:Graft Rejection; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male
D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1