Technetium-99m tetrofosmin mammoscintigraphy findings related to the expression of P-glycoprotein mediated multidrug resistance.
We studied 30 patients with infiltrating ductal breast carcinomas to evaluate the relationship between the degree of accumulation of technetium-99m tetrofosmin (Tc-TETRO) and p-glycoprotein (Pgp) expression in breast tumor tissues. All of the 30 patients underwent Tc-TETRO mammoscintigraphy to calculate breast tumor uptake of Tc-TETRO to background (T/B) ratios before surgery or biopsy. Immunohistochemical analysis was performed to determine Pgp expression in the pathological specimens of the 30 breast tumors. The T/B ratios were significantly lower for tumors in 12 patients with positive Pgp expression (Group A) than for those in 18 patients with negative expression (Group B) (1.20 +/- 0.12 and 1.94 +/- 0.30, p < 0.05). Our results supported the opinion that Tc-TETRO mammoscintigraphy is helpful for determining in vivo the presence of multidrug resistance due to Pgp expression in breast carcinoma patients.
Department of Nuclear Medicine, China Medical College Hospital.
S S
SS
Sun
J F
JF
Hsieh
S C
SC
Tsai
Y J
YJ
Ho
C H
CH
Kao
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000096:biosynthesis*; D000328:Adult; D000368:Aged; D001692:Biological Transport; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D018432:Drug Resistance, Multiple / Q000502:physiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000378:metabolism*; D015609:Organotechnetium Compounds / Q000378:metabolism*; D011877:Radionuclide Imaging
D018435:ATP Binding Cassette Transporter, Subfamily B; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; C078700:technetium tc-99m tetrofosmin