Presence of human beta-defensin-2 in oral squamous cell carcinoma.
The purpose of this study was to demonstrate immunohistochemically the localization and distribution of human beta-defensin-2 (HBD-2), a peptide with antimicrobial activity, in oral carcinoma tissues. Tissue samples were embedded in paraffin, and HBD-2 was immunostained by the streptavidin-biotin coupled peroxidase method. Cancer cells in the cornified region of well differentiated squamous cell carcinomas were stained intensely. Stained cancer cells detected by anti-HBD-2 antibody were scattered among the cells of the non-cornified region.
Department of Oral and Maxillofacial Surgery 1, Okayama University Dental School, Japan.
N
N
Mizukawa
K
K
Sawaki
E
E
Yamachika
J
J
Fukunaga
T
T
Ueno
S
S
Takagi
T
T
Sugahara
D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D002454:Cell Differentiation; D006801:Humans; D007124:Immunoenzyme Techniques; D009062:Mouth Neoplasms / Q000737:chemistry*; D009363:Neoplasm Proteins / Q000032:analysis*; D010455:Peptides / Q000032:analysis*; D023083:beta-Defensins
C106641:DEFB4A protein, human; D009363:Neoplasm Proteins; D010455:Peptides; D023083:beta-Defensins