Libman-Sacks endocarditis in a pregnant woman with acute respiratory distress syndrome.
BACKGROUND
Sterile fibrinous vegetations on the mitral valve (Libman-Sacks endocarditis) might be found in one-third of patients with antiphospholipid antibodies. Usually of minor hemodynamic significance, these vegetations might complicate acute respiratory distress syndrome in pregnancy.


METHODS
Despite delivery and aggressive medical therapy, a 17-year-old primigravida with pyelonephritis and acute respiratory distress syndrome suffered rapid decompensation. Echocardiography showed mitral valve vegetations with severe regurgitation. Blood cultures were negative, but antinuclear antibody test and lupus anticoagulant were positive. The patient died of massive cerebral infarction and brainstem herniation. Autopsy found a patent foramen ovale and Libman-Sacks endocarditis.


CONCLUSIONS
With rapid decompensation of acute respiratory distress syndrome in pregnancy, despite aggressive medical therapy, complicating processes must be considered, especially with antiphospholipid antibodies, which can be associated with sterile heart vegetations and subsequent fatal thromboembolism.
Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. audrey.kang@mcmail.vanderbilt.edu
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D000293:Adolescent; D003937:Diagnosis, Differential; D004697:Endocarditis, Bacterial / Q000150:complications / Q000175:diagnosis*; D017809:Fatal Outcome; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D012128:Respiratory Distress Syndrome / Q000209:etiology*; D013923:Thromboembolism / Q000209:etiology