[Inhibitory effect of samarium-153-labeled ethylenediaminetetramethylene phosphonate (EDTMP) on bone invasion and osteolysis in Walker 256 carcinoma bearing rats].
OBJECTIVE
To investigate the inhibitory effect of samarium-153 EDTMP on bone invasion and osteolysis in Walker 256 carcinoma bearing rats.


METHODS
Invasion and resorption of tibia by Walker 256 carcinoma in rats were evaluated by X-ray and histological examination.


RESULTS
Intravenous administration of 153Sm-EDTMP at a dose of 74 or 148 MBq/kg, the rat numbers with tibia invasion and bone resorption were reduced by fifty percent. 153Sm-EDTMP at a dose of 37 MBq/kg still exhibited inhibitory effect on bone invasion and osteolysis as compared with the control group. However, there was no indication of change in the weight of primary tumor even at the highest dose utilized.


CONCLUSIONS
Samarium-153 EDTMP can inhibit bone invasion and osteolysis by Walker 256 carcinoma in rats, but it has no effect on the growth of the transplanted tumor. Therefore, that the effect of 153Sm-EDTMP is due to a reduction in tumor growth leading to decreased bone invasion and osteolysis can be reasonably ruled out.
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
B
B
Shi
Z
Z
Fu
X H
XH
Lei
D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D002279:Carcinoma 256, Walker / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D009361:Neoplasm Invasiveness; D009942:Organometallic Compounds / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010014:Osteolysis / Q000532:radiotherapy; D011868:Radioisotopes / Q000627:therapeutic use*; D051381:Rats; D012493:Samarium / Q000627:therapeutic use*; D013977:Tibia / Q000473:pathology
D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D011868:Radioisotopes; D012493:Samarium; C061972:samarium Sm-153 lexidronam