[Familial gastric cancer].
Literature on familial gastric cancer was reviewed from the stand point of genetic and clinico-pathological aspects. Germline mutations of the E-cadherin gene were found in about one quarter of diffuse type cases of familial gastric cancer in kindreds of New Zealand and Europe, while the E-cadherin gene may not be responsible for most Japanese familial gastric cancer cases. It is likely that mismatch repair genes are not major causative genes for familial gastric cancer. Additional studies are necessary to elucidate the nature of familial gastric cancer including that of intestinal type. Prophylactic gastrectomy is effective in preventing gastric carcinoma, but it is not generally recommended at present for all E-cadherin mutation carriers in Japan.
Tokyo Medical and Dental University.
Z
Z
Nihei
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S
Iida
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K
Sugihara
D020137:Base Pair Mismatch; D015820:Cadherins / Q000235:genetics; D004260:DNA Repair; D005743:Gastrectomy; D018095:Germ-Line Mutation; D006801:Humans; D013274:Stomach Neoplasms / Q000235:genetics* / Q000517:prevention & control
D015820:Cadherins