Development of acute lymphoblastic leukemia in a child after treatment of Langerhans cell histiocytosis: report of one case.
Langerhans cell histiocytosis (LCH) is a group of poorly understood disorders. To our knowledge, LCH is a non-malignant disorder. The association of LCH with a secondary neoplasm has not been well assessed, however, a few cases have been reported. We report a case of LCH, a localized osteolytic lesion over metaphysis of left femur, who was treated with local curettage and chemotherapy with vincristine, prednisone and 6-mercaptopurine (6-MP) for eight months from end of 1991 to August, 1992. Six years later, she had acute lymphoblastic leukemia (ALL) in 1998. In review of current literature, only 5 cases of LCH, including our case, have preceded ALL. The possible association, a reactive process or a therapy-related process, between LCH and acute leukemia is still unclear at present and needs to be explored by more studies in the future.
Wu
J H
JH
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Lu
M Y
MY
Lin
K H
KH
Jou
S T
ST
Lin
D T
DT
D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000628:therapy; D006801:Humans; D007223:Infant; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000209:etiology*