Rhegmatogenous retinal detachment in retinoblastoma patients undergoing chemoreduction and cryotherapy.
OBJECTIVE
To report the development of rhegmatogenous retinal detachment, with the retinal break adjacent to a cryotherapy scar, in three patients undergoing systemic chemotherapy for intraocular retinoblastoma.


METHODS
Case series.


RESULTS
Three patients with intraocular retinoblastoma were referred after poor response to systemic chemotherapy and local cryotherapy; three eyes of these three patients were noted to have rhegmatogenous retinal detachment and active retinoblastoma, with retinal breaks adjacent to cryotherapy scars.


CONCLUSIONS
Rhegmatogenous retinal detachment may result from retinal necrosis associated with cryotherapy in the setting of intraocular retinoblastoma treated with systemic chemotherapy and local cryotherapy.
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida 33136, USA.
S R
SR
Anagnoste
I U
IU
Scott
T G
TG
Murray
D
D
Kramer
S
S
Toledano
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D003131:Combined Modality Therapy; D017679:Cryotherapy / Q000009:adverse effects*; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012163:Retinal Detachment / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D019572:Retinal Neoplasms / Q000628:therapy*; D012167:Retinal Perforations / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D012175:Retinoblastoma / Q000628:therapy*; D014463:Ultrasonography