Phenyl sulfur mustard derivatives of distamycin A.
The design, synthesis, and cytotoxic activity of novel benzoyl and cinnamoyl sulfur mustard derivatives of distamycin A are described and structure activity relationships are discussed. These sulfur mustards are more potent cytotoxics than corresponding nitrogen mustards in spite of the lower alkylating power, while their sulfoxide analogues are substantially inactive. Cinnamoyl sulfur mustard derivative (7) proved to be one of the most active distamycin-derived cytotoxics, about 1000 times more potent than melphalan.
Cozzi
P
P
Department of Chemistry, Pharmacia & Upjohn, Discovery Research Oncology, Milan, Italy. paolo.cozzi@eu.pnu.com
Beria
I
I
Caldarelli
M
M
Capolongo
L
L
Geroni
C
C
Mazzini
S
S
Ragg
E
E
D004214:Distamycins / Q000737:chemistry / Q000494:pharmacology*; D009150:Mustard Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
D004214:Distamycins; D009150:Mustard Compounds; C030000:stallimycin