Adsorption of bilirubin by amine-containing crosslinked chitosan resins.
Crosslinked chitosan resin, which has good blood compatibility, was prepared by crosslinking chitosan solution with glutaraldehyde. Polymeric adsorbents for bilirubin have been synthesized by chemical modification of crosslinked chitosan resins with di-, tri-, tetra-, and pentammines. The adsorption of bilirubin on the adsorbents was investigated in detail. The results indicated that electrostatic interaction and hydrophobic interactions are the main driving forces for the adsorption. Compared with crosslinked chitosan resin, the functionalized chitosan beads have higher adsorption capacity for unconjugated and conjugated bilirubin.
Department of Biochemical Engineering, Tianjin University, PR China.
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D000327:Adsorption; D000588:Amines / Q000737:chemistry*; D000818:Animals; D001663:Bilirubin / Q000737:chemistry / Q000493:pharmacokinetics*; D001790:Blood Physiological Phenomena / Q000187:drug effects; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics*; D048271:Chitosan; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004285:Dogs; D005404:Fixatives / Q000737:chemistry; D005976:Glutaral / Q000737:chemistry; D006464:Hemoperfusion / Q000379:methods; D006932:Hyperbilirubinemia / Q000628:therapy; D008863:Microspheres; D012116:Resins, Plant / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013696:Temperature
D000588:Amines; D003432:Cross-Linking Reagents; D005404:Fixatives; D012116:Resins, Plant; D002686:Chitin; D012710:Serum Albumin, Bovine; D048271:Chitosan; D001663:Bilirubin; D005976:Glutaral