Multiple fish vertebra deformity in child with systemic lupus erythematosus: a case report.
We report an 11-year-old female patient with multiple fish vertebra deformity, which occurred in the course of treatment with corticosteroids for systemic lupus erythematosus (SLE). She was treated for SLE with predonisolone (30 mg per day) from April 2, 1996, and presented at our outpatient clinic for an osteoporosis check-up on April 27. She was 132 cm tall with-1.7 standard deviation of the average height, and X-ray examination revealed no evidence of osteoporosis in the spine. Bone mineral density (BMD) was 74.7% of the average BMD. Subsequently, she grew to 136 cm in September. However she began to have low back pain (LBP) from November, and received alfacalcidol. LBP deteriorated after pulse therapy with methylpredonisolone. In June 1997, X-ray examination revealed multiple fish vertebra deformity with 58.3% of the average BMD. Moreover her height had decreased to 131cm. She underwent combination therapy with elcatonin and alfacalcidol. In September 1999, she had no LBP nor progression of fish vertebra deformity. However she had no growth in height. Corticoseroids and SLE have multiple effects on bone metabolism, making the treatment of porosis complicated and difficult.
Department of Orthopedic Surgery, Nippon Medical School, Kanagawa, Japan. daiya@nms.ac.jp
D
D
Ozaki
Y
Y
Shirai
Y
Y
Nakayama
K
K
Yoshihara
T
T
Huzita
D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000188:drug therapy / Q000209:etiology*; D002116:Calcitonin / Q000031:analogs & derivatives / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D017116:Low Back Pain / Q000188:drug therapy / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008775:Methylprednisolone / Q000009:adverse effects; D011239:Prednisolone / Q000009:adverse effects; D013121:Spinal Curvatures / Q000188:drug therapy / Q000209:etiology*
D000893:Anti-Inflammatory Agents; D006887:Hydroxycholecalciferols; D002116:Calcitonin; D011239:Prednisolone; C008088:alfacalcidol; C012755:elcatonin; D008775:Methylprednisolone