The constituents of the root and stem of Aristolochia cucurbitifolia Hayata and their biological activity.
Four new compounds, three phenanthrene derivatives, aristolochic acid-III methyl ester (1), cepharanone C (2), and sodium 7-hydroxyl-8-methoxyaristolate (3), and the benzoate derivative, sodium 3,4-dimethoxybenzoate (4), together with 53 known compounds were isolated and characterized from the fresh root and stem of Aristolochia cucurbitifolia. Their structures were elucidated by spectral analyses and chemical transformations. The cytotoxicity and antiplatelet activity of the isolated compounds are also discussed.
Department of Chemisty, National Cheng Kung University, Tainan, Taiwan, ROC. tswu@mail.ncku.edu.tw
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Wu
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Chan
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Leu
D000818:Animals; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D018922:HL-60 Cells; D019073:HT29 Cells; D006801:Humans; D007624:KB Cells; D019684:Magnoliopsida / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D014407:Tumor Cells, Cultured
D001565:Benzoates; D010616:Phenanthrenes; D010975:Platelet Aggregation Inhibitors