[Synthesis and antioxidant activity of azole derivatives of hemin].
New derivatives of proto- and deuterohemin IX containing tri- and tetrazole rings were synthesized and characterized. A pronounced antioxidant activity was found for these compounds in the Fe(II)/ascorbate-dependent system of lipid peroxidation in murine liver homogenates.
Rozhkova
E A
EA
Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia. e_rozhkova@yahoo.com
Lysko
A I
AI
Kuleshov
K V
KV
Evstigneeva
R P
RP
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001393:Azoles / Q000737:chemistry*; D006427:Hemin / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D051381:Rats
D000975:Antioxidants; D001393:Azoles; D006427:Hemin