Behavioral characterisation of the flavonoids apigenin and chrysin.
The behavioral effects of acute administration of two flavonoids, apigenin and chrysin, contained in Matricaria chamomilla and in Passiflora incarnata, respectively, were studied in rats. The data demonstrate that in our experimental conditions, the two flavonoids were equally able to reduce locomotor activity when injected in rats at a minimal effective dose of 25 mg/kg. However, while chrysin exhibited a clear anxiolytic effect when injected at the dose of 1 mg/kg, apigenin failed to exert this activity. The sedative effect of these flavonoids cannot be ascribed to an interaction with GABA-benzodiazepine receptors, since it was not counteracted by the benzodiazepine antagonist Flumazenil. To the contrary, the anxiolytic effect of chrysin, which was blocked by the injection of Flumazenil, could be linked to an activation of the GABA(A) receptor unit.
Department of Pharmaceutical Sciences, Modena and Reggio Emilia University, Modena, Italy. zanoli.paola@unimo.it
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D047310:Apigenin; D001522:Behavior, Animal / Q000187:drug effects*; D004121:Dimethyl Sulfoxide; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D005442:Flumazenil / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D031168:Matricaria; D009043:Motor Activity / Q000187:drug effects; D029598:Passiflora; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects
D014151:Anti-Anxiety Agents; D005419:Flavonoids; D010936:Plant Extracts; C043561:chrysin; D005442:Flumazenil; D047310:Apigenin; D004121:Dimethyl Sulfoxide