[The value of plasma antiretroviral drug monitoring in the management of HIV infected patients].
Antiretroviral drugs exhibit significant between-patient pharmacokinetic variability. Over the past years, data have emerged demonstrating a link between antiretroviral drug concentrations and efficacy or side-effects. As a result, the issue of therapeutic drug monitoring for these compounds are arisen; many published studies provided evidence that plasma concentrations contributes to therapeutic response. However, further information must be collected to define more precisely the therapeutic concentrations and the indications of therapeutic drug-monitoring for each drug.
Service de Pharmacologie Clinique, Hôpital Saint-Vincent-de-Paul, 82, avenue Denfert-Rochereau, 75674 Paris Cedex 14.
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Tréluyer
D019380:Anti-HIV Agents / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring / Q000379:methods*; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D018579:Patient Selection; D016896:Treatment Outcome
D019380:Anti-HIV Agents