[Early postoperative intraperitoneal perfusion chemotherapy for advanced colorectal cancer].
OBJECTIVE
To study the effect of early postoperative intraperitoneal perfusion chemotherapy (IPPC) on the prevention of peritoneal recurrence and liver metastasis in patients with advanced colorectal cancer.


METHODS
From 1990 through 1997, 102 patients with advanced colorectal cancer were admitted. The tumor invaded the intestinal serosa with elevated CEA in the peritoneal fluid. Fifty-four of the 102 patients, beginning from the operation day, were given IPPC, once per day for 6 days, with warm(43-45 degrees C) sterile double distilled water containing 1 g 5-Fu and 10 mg MMC. The other 48 patients, as control, received 1 g 5-Fu and 8 mg MMC by i.v. infusion, once per day for 6 days. In addition, oral tegafur was given to all patients with a total dose of 40 g.


RESULTS
In patients treated with IPPC, peritoneal recurrence developed in 2 patients, liver metastasis in 2 patients whereas 12 cases had peritoneal recurrence and 6 had liver metastasis in patients treated by i.v. infusion. No complication developed in any of the treated patients.


CONCLUSIONS
IPPC is effective in preventing tumor recurrence in the peritoneal cavity and metastasis to the liver in patients with advanced colorectal cancer. The treatment procedure is simple and safe.
Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing.
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Sun
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Cai
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Zhang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010533:Peritoneal Lavage / Q000379:methods*; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000517:prevention & control; D011184:Postoperative Period; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000601:surgery