All B cells are progeny of endothelial cells: a new perspective.
We present here a speculative view of embryonic hematopoiesis. We do this with the hope of finding directions for future study, keeping in mind that our model may diverge from the real situation. However, we want to emphasize that previous models have neglected the possibility that endothelial cells (EC) represent a progenitor of hematopoietic cells (HPC). Emerging evidence, including our own, and previous histological studies argue for the presence of hemogenic EC. We discuss seemingly contradictory points of view of embryonic hematopoiesis, such as the origin of lymphogenic progenitors, and have shown that they may be resolved more satisfactorily by introducing this notion. Obviously, a good model should be a testable one, so we are currently developing experimental systems to demonstrate that all B cells are, indeed, the progeny of EC.
Nishikawa
S I
SI
Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Japan. snishika@virus.kyoto-u.ac.jp
Fraser
S
S
Fujimoto
T
T
Endoh
M
M
Nishikawa
S
S
Ogawa
M
M
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D019070:Cell Lineage; D004727:Endothelium / Q000276:immunology*; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000276:immunology; D008648:Mesoderm / Q000276:immunology; D051379:Mice; D008954:Models, Biological