Organization and reorganization of human swallowing motor cortex: implications for recovery after stroke.
Swallowing problems can affect as many as one in three patients in the period immediately after a stroke. In some cases this can lead to serious morbidity, in particular malnutrition and pulmonary aspiration. Despite this, swallowing usually recovers to a safe level in the majority of patients within weeks. This propensity for recovery is likely to relate to how the swallowing motor cortex is organized and then reorganized after cerebral injury. In this review, we examine present knowledge on the cortical control of swallowing in humans, and examine the aspects of its organization that are important for compensating for recovery after damage. In addition, we examine approaches which may be useful in speeding up the process of recovery. Swallowing may turn out to be a useful model for studying central nervous system plasticity.
Department of GI Science, Hope Hospital, University of Manchester, Manchester M6 8HD, UK. shamdy@fs1.ho.man.ac.uk
S
S
Hamdy
J C
JC
Rothwell
Q
Q
Aziz
D G
DG
Thompson
D000818:Animals; D003679:Deglutition / Q000502:physiology*; D003680:Deglutition Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D004750:Enteral Nutrition / Q000379:methods; D006801:Humans; D009044:Motor Cortex / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D020521:Stroke / Q000150:complications / Q000503:physiopathology / Q000628:therapy*