[The observation on treatment effects of local adoptive immunotherapy in 33 cases with head and neck cancer].
OBJECTIVE
To evaluate treatment effects of local adoptive immunotherapy in 33 cases with head and neck cancer.


METHODS
IL-2 1 x 10(5)-2 x 10(5) U per day was injected into tumor for 10 days; during the 4th-8th day LAK cells 1.0 x 10(8)-5.0 x 10(8) per day were combined with IL-2 injection. Then we analysized clinical effect, immunopathology, side effects, etc.


RESULTS
CR was seen in 1 case; PR in 6, MR in 20 cases, and SD in 6 cases. The one-, two- and three-year survival rate was 96.3%, 83.3% or 75.0% respectively. The results of histopathology showed that there were large amount of T lymphocytes (CD3+/4+) infiltrating in the tumor area after immunotherapy. No serious side effects were found during the course of the treatment.


CONCLUSIONS
Local injection of IL-2/LAK can be used as immunotherapy for head and neck cancer.
Beijing Institute of Otolaryngology.
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Han
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Zhu
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Huang
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000627:therapeutic use; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation*; D007822:Laryngeal Neoplasms / Q000628:therapy; D008297:Male; D008875:Middle Aged
D007376:Interleukin-2