Photic driving response in primary headache: diagnostic value tested by discriminant analysis and artificial neural network classifiers.
The aim of this study was to discriminate migraine patients (MWoA) from tension-type headache (TTH) patients and normals in order to confirm that the photic driving response in the medium frequency range is a marker of migraine and to test the hypothesis that MWoA and TTH are separate disorders based on electrophysiological pattern. We recruited 120 MWoA patients, 64 TTH patients, and 51 healthy controls without any history of headache or of migraine inheritance, according to International Headache Society (IHS) criteria. The classification method was discriminant analysis using both linear discriminant analysis with a stepwise selection of predictors and an artificial neural network classifier (NNs). The mean amplitude of the first harmonic elicited by flash stimulation in the 15-27 Hz range was significantly increased over Fp1, C3, C4, P4, O2, and O1 electrodes in MWoA and TTH patients in comparison with normal subjects. Using both classification methods, only the control subjects were correctly distinguished. When only the patient groups were matched, no significant difference was detectable. The increased brain response to visual stimulation detected in both migraine and TTH suggests a common neuronal dysfunction in the two headache subtypes.
1st Neurological Clinic, Department of Neurological and Psychiatric Sciences, Policlinico, University of Bari, Italy.
M
M
de Tommaso
V
V
Sciruicchio
R
R
Bellotti
M
M
Guido
G
G
Sasanelli
L M
LM
Specchio
F
F
Puca
D000293:Adolescent; D000328:Adult; D003936:Diagnosis, Computer-Assisted; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D020326:Migraine without Aura / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D016571:Neural Networks, Computer; D010775:Photic Stimulation / Q000009:adverse effects*; D016037:Single-Blind Method; D018781:Tension-Type Headache / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology