Dose-dependent neuroprotection with tiagabine in a focal cerebral ischemia model in rat.
Enhancement of the inhibitory activity of GABA may protect ischemic neurons. We evaluated the neuroprotective effect of tiagabine, a novel GABA agonist, in reversible focal cerebral ischemia rats subjected to 2h middle cerebral artery (MCA) occlusion. Tiagabine was given at 10, 20 and 40 mg/kg, i.p., 2 h after the onset of reperfusion. We found that post-ischemia treatment with tiagabine improved neurobehavioral outcome and reduced brain infarction volume in a dose-dependent manner. The data suggest that post-ischemic administration of tiagabine is neuroprotective in the focal cerebral ischemia model.
Department of Medicine, University of Alberta Hospital, Edmonton, Canada.
Y
Y
Yang
Q
Q
Li
C X
CX
Wang
T
T
Jeerakathil
A
A
Shuaib
D000818:Animals; D001921:Brain / Q000473:pathology; D002544:Cerebral Infarction / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D018755:GABA Agonists / Q000494:pharmacology; D020766:Intracranial Embolism / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology* / Q000517:prevention & control*; D008297:Male; D020768:Middle Cerebral Artery; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009557:Nipecotic Acids / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000078308:Tiagabine
D018755:GABA Agonists; D018696:Neuroprotective Agents; D009557:Nipecotic Acids; D000078308:Tiagabine