Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone.
Crude ethanol extracts of 18 medicinal plants from Sierra Leone, West Africa were examined for antiplasmodial activity against Plasmodium falciparum, using an in vitro microtest. Eleven of these extracts were also screened for in vitro antiamoebic activity against Entamoeba histolytica. Only one plant extract, Triclisia patens (Menispermaceae) showed significant antiplasmodial activity (IC(50) = 8 microg/mL). None of the plant extracts was effective against Entamoeba histolytica.
Marshall
S J
SJ
Pharmaceutical Sciences Research Group, Department of Pharmacy, University of Brighton, UK.
Russell
P F
PF
Phillipson
J D
JD
Kirby
G C
GC
Warhurst
D C
DC
Wright
C W
CW
D000818:Animals; D004404:Dysentery, Amebic / Q000188:drug therapy; D004748:Entamoeba histolytica / Q000187:drug effects*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D016488:Medicine, African Traditional; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects*; D012807:Sierra Leone
D010936:Plant Extracts