Hydrochlorothiazide prevents bone loss in castrated male mice.
The castration of male mice results in osteopenia which is a suitable model for evaluating the effect of thiazides on bone. The bones of castrated mice were characterized by a decrease of ash weight, bone density and calcium and phosphate bone content. When such castrated mice were treated with high dose of hydrochlorothiazide (2 mg/day/mouse) the changes in bone density and bone mineral concentration resulting from the castration were prevented. Our data indicate a beneficial effect of long-term thiazide administration on bone mineral content in male mice, which is dose dependent.
Broulik
PD
3rd Department of Internal Medicine, Charles University, Faculty of Medicine, Prague, Czech Republic.