Risk ranges for various endpoints following exposure to 2,3,7,8-TCDD.
Conducting a dose-response analysis for an environmental contaminant requires a careful evaluation of most of the available data focusing on both the magnitude of the effect and the possible ranges of dose-response shapes which fit the data. This paper calculates potency values (1% response exposures) for human and animal data on cancer, non-cancer and biological effect endpoints for TCDD and finds that a reasonable estimate for 1% excess cancer would be between 1 and 50 pg/kg/day. The paper also evaluates the adequacy of linear and non-linear models for fitting these data and concludes that the assumption of a threshold dose-response is not fully supported by these data.
National Institute of Environmental Health Sciences, Laboratory of Computational Biology and Risk Analysis, Research Triangle Park, NC 27709, USA. portier@niehs.nih.gov
C
C
Portier
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced; D016273:Occupational Exposure; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D018570:Risk Assessment
D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins