With the benefit of hindsight.
The development of a method to produce monoclonal antibodies against a defined antigen has had profound impact in many branches of research and signalled a shift in the analysis of biological problems. This article describes the background to these developments and their important practical applications that impinge on the relationship between the world of basic science and commerce.
Milstein
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Medical Research Council Laboratory of Molecular Biology, MRC Centre, Hills Rd, Cambridge, UK CB2 2QH.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics / Q000276:immunology*; D000915:Antibody Affinity; D000916:Antibody Diversity; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D015723:Gene Library; D005818:Genetic Engineering / Q000379:methods; D006801:Humans; D006825:Hybridomas / Q000276:immunology*; D010330:Patents as Topic
D000911:Antibodies, Monoclonal; D000941:Antigens