Lysosomotropic detergents induce time- and dose-dependent apoptosis/necrosis in cultured cells.
Brunk
U T
UT
Department of Pathology II, University of Linköping, Sweden. ulf.brunk@pat.liu.se
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002460:Cell Line; D003902:Detergents / Q000494:pharmacology*; D006801:Humans; D019169:Jurkat Cells; D007700:Kinetics; D008247:Lysosomes / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D009336:Necrosis; D013110:Sphingosine / Q000494:pharmacology*; D020298:U937 Cells
D003902:Detergents; C505407:CASP3 protein, human; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases; D013110:Sphingosine