The rel gene is essential for in vitro growth of Staphylococcus aureus.
The stringent response in Staphylococcus aureus is mediated by the nucleotide guanosine pentaphosphate, whose synthesis is catalyzed by the product of the rel gene. We report here that the rel gene is essential for the in vitro growth of S. aureus, distinguishing it from all other bacteria tested for this requirement.
SmithKline Beecham Pharmaceuticals, Collegeville, Pennsylvania 19426, USA. dan_r_gentry@sbphrd.com
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Gentry
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D005798:Genes, Bacterial; D008025:Ligases / Q000235:genetics*; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development*
D008025:Ligases; C028812:guanosine 3',5'-polyphosphate synthetases