Resistance of recent measles virus wild-type isolates to antibody-mediated neutralization by vaccinees with antibody.
The neutralization capacity of sera from Luxembourgian adolescent vaccinees and from Nigerian women with measles-induced immunity to a number of measles virus strains was compared. Although both cohorts were matched for their hemagglutination inhibition and standard neutralization titers, 12 of the 22 late convalescent sera, and only 6 of 24 vaccinees neutralized all viruses. Similarly, only 2 of 20 viruses were not neutralized by at least 75% of late convalescent sera, in comparison to 10 of 20 viruses that resisted neutralization by at least 75% of the vaccinees. The more resistant viruses were not limited to a certain clade. One Nigerian virus was resistant to neutralization by 30% of the late convalescent women and by 75% of vaccinees. These results suggest that qualitative differences in neutralizing antibodies may reduce further protection of infants by passively acquired immunity against wild-type viruses when vaccinated girls become mothers.
Department of Immunology, Laboratoire National de Santé Luxembourg.
M
M
Klingele
H K
HK
Hartter
F
F
Adu
W
W
Ammerlaan
W
W
Ikusika
C P
CP
Muller
D000293:Adolescent; D000917:Antibody Formation; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000032:analysis; D008297:Male; D008457:Measles / Q000276:immunology / Q000517:prevention & control / Q000821:virology*; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology* / Q000302:isolation & purification; D009500:Neutralization Tests; D014611:Vaccination
D007106:Immune Sera; D008458:Measles Vaccine