[Clinical observation on the adhesion molecule expression and functional study of platelets in cancer patients].
OBJECTIVE
To investigate adhesion molecule expression and functional status of platelets in cancer patients and their relation to cancer progression.


METHODS
Using flow cytometry to measure the expression of surface antigens and functional status of platelets in 50 healthy donors and 181 cancer patients.


RESULTS
Comparing with normal donors, the expression of CD42a in cancer patients decreased, and that of TSP and CD36 increased. The number of platelets with CD36+ TSP+, CD36+ TSP-, CD9+, CD31+, CD62+ CD63-, CD62+ CD63+, CD62- CD63+ phenotypes also increased. There was significant difference between patients in early stage and those in advanced stage, but there was no significant difference between the patients in early stage and healthy donors. The expression of CD41 did not change in cancer patients.


CONCLUSIONS
In cancer patients, especially in the advanced stage of the disease, the expression of the adhesion molecules on platelets and their released products increase, indicative of an activated state of the platelets.
Tumor Department, Guanganmen Hospital, China Academy of Traditional Chinese Medicine, Beijing.
P
P
Zhang
Y
Y
Pei
B
B
Piao
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D001792:Blood Platelets / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood; D018955:CD36 Antigens; D015815:Cell Adhesion Molecules / Q000097:blood; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood*; D015539:Platelet Activation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism*; D010980:Platelet Membrane Glycoproteins; D013274:Stomach Neoplasms / Q000097:blood; D060149:Tetraspanin 30; D019700:Thrombospondin 1 / Q000097:blood
D015703:Antigens, CD; D018955:CD36 Antigens; C554586:CD63 protein, human; D015815:Cell Adhesion Molecules; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30; D019700:Thrombospondin 1