Chemistry of glucose and biochemical pathways of biological interest.
Glucose degradation, yielding GDPs, can take place in vivo or during heat treatment of glucose solutions. AGEs are formed from the interaction of D-glucose with reactive amino-acid side chains of proteins. Both GDPs and AGEs have been shown to impair cellular function. GDPs have additional damaging effects because they strongly promote AGE formation (as compared to D-glucose).
Institut für Pharmazie und Lebensmittelchemie, Friedrich-Alexander-Universität, Erlangen, Germany.
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Pischetsrieder
D005947:Glucose / Q000737:chemistry* / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015416:Maillard Reaction
D017127:Glycation End Products, Advanced; D005947:Glucose