AMP-activated protein kinase: a critical signaling intermediary for exercise-stimulated glucose transport?
Physical exercise increases the rate of glucose transport into contracting skeletal muscles by a mechanism that involves translocation of the GLUT4 glucose transporter to the cell surface. This brief report will discuss an emerging hypothesis that suggests that the AMP-activated protein kinase is a key signaling intermediary leading to exercise-stimulated GLUT4 translocation in skeletal muscle.
Goodyear
L J
LJ
Research Division, Joslin Diabetes Center, Boston, MA 02215, USA. laurie.goodyear@joslin.harvard.edu
D055372:AMP-Activated Protein Kinases; D001692:Biological Transport; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D009004:Monosaccharide Transport Proteins / Q000502:physiology; D009097:Multienzyme Complexes / Q000378:metabolism*; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
D009004:Monosaccharide Transport Proteins; D009097:Multienzyme Complexes; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose