Spontaneous cerebral haemorrhage without hypertension in non-mosaic 45X Turner's syndrome.
Cerebral haemorrhage without hypertension, arteriosclerosis or clotting defect has not been reported in patients with Turner's syndrome before. In a 51 year old female patient with non-mosaic Turner's syndrome, acute aphasia and right-sided hemiplegia occurred, due to left-sided basal ganglia haemorrhage. The history for hypertension was negative, blood pressure was normal throughout hospitalisation as well as during 24 h monitoring, and all tests for secondary hypertension were negative. There was no indication of arteriosclerosis or a clotting defect. Since there were hypermobile joints, hyperextensible skin and ectatic ascending aorta and brachiocephalic trunk on angiography, a general connective tissue defect was assumed, making arteries more vulnerable to physiologically increased blood pressure and rupture of intracerebral arteries with consecutive bleeding.
Neurological Department, Neurological Hospital Rosenhügel, Vienna, Austria. fj@2nr.nkr.magwien.gv.at
J
J
Finsterer
M
M
Zartl
P
P
Samec
D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D002536:Cerebral Arteries / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009030:Mosaicism / Q000473:pathology*; D011859:Radiography; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology; D014652:Vascular Diseases / Q000150:complications / Q000209:etiology / Q000473:pathology