[Nephrolithiasis].
The development of efficacious techniques for stone elimination, and in particular of extracorporeal lithotripsy, slackened, in the last two decades, the pharmacological research on nephrolithiasis, with the result that the currently available efficacious drugs are very few. Instead, the recent elucidation of some relevant etiopathogenetic aspects, with special reference to the quantitative and qualitative changes of specific urinary inhibitors of crystallization, could open new therapeutic avenues for many lithiasic forms, now considered idiopathic.
Dipartimento di Farmacologia delle Sostanze Naturali e Fisiologia Generale, Università La Sapienza, Roma.
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L
Saso
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Silvestrini
D002118:Calcium / Q000652:urine; D002129:Calcium Oxalate / Q000037:antagonists & inhibitors; D003460:Crystallization; D004032:Diet; D006023:Glycoproteins; D006801:Humans; D007669:Kidney Calculi / Q000737:chemistry / Q000209:etiology / Q000628:therapy; D008096:Lithotripsy; D017616:Magnesium Compounds; D010710:Phosphates; D012106:Research; D000069877:Struvite; D007507:Therapeutic Irrigation; D014527:Uric Acid
D006023:Glycoproteins; D017616:Magnesium Compounds; D010710:Phosphates; C029490:nephrocalcin; D002129:Calcium Oxalate; D014527:Uric Acid; D000069877:Struvite; D002118:Calcium