Transmission of parasites and bacteria by blood components.
OBJECTIVE
Although most attention has been paid to viral infections as a complication of transfusion, some parasitic infections are readily transmissible and generate a heavy burden of disease, particularly in the developing world. Additionally, bacterial infection as a result of transfusion is the most frequent serious outcome of transfusion in the developed world.


METHODS
Review of current literature and ongoing research studies.


RESULTS
Malaria and Chagas' disease continue to be a serious problem in endemic areas, but are also of concern as a result of their introduction into other regions. Means to control or detect bacterial contamination, particularly of platelet concentrates, are needed, but no simple, effective approach is available.


CONCLUSIONS
Continued development and implementation of tests and of inactivation procedures will result in the eventual control of transfusion-transmitted parasitic and bacterial disease.
American Red Cross Holland Laboratory, Rockville, MD 20855, USA. dodd@usda.redcross.org
R Y
RY
Dodd
D001424:Bacterial Infections / Q000097:blood / Q000635:transmission*; D001781:Blood Component Removal / Q000009:adverse effects*; D006801:Humans; D010272:Parasitic Diseases / Q000097:blood / Q000635:transmission*; D065227:Transfusion Reaction