Porcine islets of langerhans isolated from normal and hDAF transgenic pigs elicit the same acute inflammatory reaction during exposure to human blood; inhibition of the response with soluble complement receptor 1 and heparin.
Department of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, Huddinge, Sweden.
W
W
Bennet
B
B
Sundberg
Z
Z
Song
G
G
Elgue
L
L
Wennberg
A
A
Richards
D J
DJ
White
R
R
Larsson
B
B
Nilsson
C
C
Groth
O
O
Korsgren
D000818:Animals; D030801:Animals, Genetically Modified; D001790:Blood Physiological Phenomena; D018958:CD55 Antigens / Q000235:genetics / Q000502:physiology*; D003169:Complement Inactivator Proteins / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D011951:Receptors, Complement / Q000235:genetics / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology
D018958:CD55 Antigens; D003169:Complement Inactivator Proteins; D011951:Receptors, Complement; D011994:Recombinant Proteins; C082885:soluble complement inhibitor 1; D006493:Heparin