Effect of HD-03--a herbal formulation in galactosamine-induced hepatopathy in rats.
The effect of HD-03 a herbal preparation was studied on galactosamine (400 mg/kg b.wt., i.p.) induced hepatotoxicity in rats. Animals were pre-treated for 14 days with HD-03 and compared against untreated group for SGPT, SGOT, serum bilirubin and liver glycogen. Histopathology of liver lobes was considered to evaluate the extent of hepatic injury induced by galactosamine. These were reversed by HD-03 pre-treatment. HD-03 provided convincing evidence of hepatoprotection against galactosamine induced hapatotoxicity.
R & D Centre, Himalaya Drug Co., Makali, Bangalore.
S K
SK
Mitra
S J
SJ
Seshadri
M V
MV
Venkataranganna
S
S
Gopumadhavan
U V
UV
Udupa
D N
DN
Sarma
D000818:Animals; D001652:Bile Ducts / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D005688:Galactosamine; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D019684:Magnoliopsida / Q000627:therapeutic use*; D008297:Male; D009336:Necrosis; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
C119007:HD 03 polyherbal; D010936:Plant Extracts; D005688:Galactosamine