Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from Brazil.
Mutations in a 69-bp region of the rpoB gene associated with rifampin resistance (Rif(r)) in 100 isolates (82 Rif(r)) from three states of Brazil were studied. Twenty-one different kinds of mutations were identified in the Rif(r) isolates, and six new alleles are described.
Valim
A R
AR
Laboratório Central do Rio Grande do Sul, Fundação Estadual de Produção e Pesquisa em Saúde, Porto Alegre-Rio Grande do Sul CEP 90130-001, Brazil.
Rossetti
M L
ML
Ribeiro
M O
MO
Zaha
A
A
D000995:Antitubercular Agents / Q000494:pharmacology*; D001938:Brazil / Q000453:epidemiology; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D017422:Sequence Analysis, DNA; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000382:microbiology*
D000995:Antitubercular Agents; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit