Haemocompatibility of coronary catheters.
BACKGROUND
Unwanted side-effects like thrombotic-thromboembolic processes accompany the intravascular use of catheters. The influence of the physico-chemical properties of the catheter materials on these processes is not completely understood.


METHODS
The haemocompatibility of angiography-catheters (n = 10) (Super Torque Plus, CORDIS, Johnson & Johnson company) was examined in a perfusion-model filled with platelet-rich plasma and either compared to a non-thrombogenic (silicon-tube) or to a thrombogenic surface (glass). As test-parameters the number of single circulating thrombocytes, of circulating platelet-aggregates, of circulating activated thrombocytes (CD62) and the thrombin generation (thrombin antithrombin III-complexes) were evaluated.


RESULTS
None of the test-parameters showed differences between the non-thrombogenic control-system and the angiography-catheters. Both systems, however, differed significantly and relevantly from the system filled with the glass-beads (the thrombogenic control-systems).


CONCLUSIONS
With respect to the platelet reactivity angiography-catheters of the examined type can therefore be regarded as non-thrombogenic or haemocompatible.
Dresdner Institut für Herz- und Kreislaufforschung, Dresden.
C
C
Mrowietz
R
R
Bach
U
U
Seyfert
J W
JW
Park
R P
RP
Franke
F
F
Jung
D006328:Cardiac Catheterization / Q000295:instrumentation*; D017023:Coronary Angiography / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D066298:In Vitro Techniques; D015539:Platelet Activation / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology; D010976:Platelet Count; D013917:Thrombin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood / Q000209:etiology*
D013917:Thrombin