Nutritional and insulin regulation of leptin gene expression.
The leptin and lipogenic enzyme genes contain the common DNA sequences of binding sites for Sp1 proteins. These sites appear to be responsible for glucose/insulin stimulation and polyunsaturated fatty acid suppression. In rat adipose tissue leptin and lipogenic gene expression is similarly regulated by nutritional manipulation. Interestingly, leptin has the ability to down-regulate lipogenic enzyme expression.
Department of Human and Cultural Studies, Tezukayama Gakuin University, Sakai, Osaka, Japan. iritani@hcs.tezuka-gu.ac.jp
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Iritani
D000103:Acetyl-CoA Carboxylase / Q000235:genetics; D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D020738:Leptin / Q000235:genetics*; D008055:Lipids / Q000096:biosynthesis; D008291:Malate Dehydrogenase / Q000235:genetics; D009747:Nutritional Physiological Phenomena; D016329:Sp1 Transcription Factor / Q000378:metabolism
D007328:Insulin; D020738:Leptin; D008055:Lipids; D016329:Sp1 Transcription Factor; D004247:DNA; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D000103:Acetyl-CoA Carboxylase; D005947:Glucose