Synthesis of aminomethyl derivatives of 4-phenyl-1,2,4-triazolin-5-one-1-acetic acid amide and 3,4-diphenyl-1,2,4-triazolin-5-one-1-acetic acid amide.
Ehtyl esters of 4-phenyl-1,2,4-triazolin-5-one-1-acetic acid and 3,4-diphenyl-1,2,4-triazolin-5-one-1-acetic acid were transformed into the corresponding amides [Ia, b]. The aminomethylation reactions afforded Mannich bases [IIa, b-VIa, b] exhibiting the expected pharmacological effects.
Dobosz
M
M
Department of Organic Chemistry, Medical University, Lublin.
Struga
M
M
D000818:Animals; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007928:Lethal Dose 50; D051379:Mice
D002492:Central Nervous System Depressants