The zitter mutant rat exhibits loss of D3 receptors with degeneration of the dopamine system.
Experimental studies of the regulation of the dopamine (DA) D3 receptor have utilized techniques causing massive depletions of the DA system. Zitter mutant rats exhibiting a heterogeneous loss of striatal DA innervation were examined for DA transporter (DAT) binding and DA D3 receptor number by autoradiography and compared with Sprague-Dawley rats. A significant loss of DAT binding was observed with the greatest in the lateral caudate-putamen (72% loss) and the least in the nucleus accumbens (45% loss). DA D3 receptors were reduced by > 70% in all regions, even in the nucleus accumbens that exhibited considerably smaller depletions of DAT binding, indicating that loss of D3 receptors may occur prior to massive loss of DA innervation.
Thomas H. Christopher Center for Parkinson's Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA.
J N
JN
Joyce
K
K
Yoshimoto
S
S
Ueda
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D003042:Cocaine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D051381:Rats; D011922:Rats, Mutant Strains; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; C493595:Drd3 protein, rat; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C493216:Slc6a3 protein, rat; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine; D004298:Dopamine