Studies on adsorption characteristics of bile acids and methotrexate to a new type of anion-exchange resin, colestimide.
The adsorption characteristics of various bile acids and methotrexate to a new type of anion-exchange resin, colestimide, were studied in vitro and compared with those to cholestyramine. For bile acids, colestimide was shown to have a higher capacity than cholestyramine. For example, approximately 1.4-fold higher for cholic acid and 2.0-fold for deoxycholic acid in water. In the presence of physiological anions, the degree of adsorption of cholic acid to both resins was greatly reduced, whereas adsorption of deoxycholic acid was only slightly reduced. Furthermore, the bed-volume of colestimide swelled about 6.8-fold in water, hence the anion-exchange groups of this resin are expected to be able to function effectively in adsorption of bile acids in the gut. In addition, colestimide was found to have high adsorption capacity for methotrexate, not only in water but also in media containing various physiological anions, and thus it is suggested that colestimide is a potential oral antidote to reduce possible toxicity by methotrexate through interruption of enterohepatic circulation.
Department ofPharmacy, Kumamoto University Hospital, Japan.
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Honda
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Nakano
D000837:Anion Exchange Resins / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics; D000931:Antidotes / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000737:chemistry* / Q000493:pharmacokinetics; D004811:Epichlorohydrin; D006801:Humans; D007093:Imidazoles; D007408:Intestinal Absorption; D008727:Methotrexate / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics; D012117:Resins, Synthetic; D014867:Water / Q000737:chemistry
D000837:Anion Exchange Resins; D000931:Antidotes; D001647:Bile Acids and Salts; D007093:Imidazoles; D012117:Resins, Synthetic; C417427:colestimide; D014867:Water; D004811:Epichlorohydrin; D008727:Methotrexate