The genetics of childhood psychiatric disorders: a decade of progress.
OBJECTIVE
To review the literature over the past decade on the genetics of childhood neuropsychiatric disorders.


METHODS
A computerized search was performed for articles published in the past decade, and selected papers were highlighted.


RESULTS
The past decade of research has illuminated the complex genetics of early-onset mental disorders. Advances in statistical methodologies and laboratory-based gene-hunting techniques are laying the foundation for a deeper understanding of both the biological and environmental factors that contribute to mental illness. Researchers are on the verge of identifying and characterizing genetic vulnerabilities involved in common childhood psychiatric syndromes.


CONCLUSIONS
Although the study of the genetics of childhood psychiatric disorders has advanced significantly over the past decade, considerable work remains. The identification of genes conferring vulnerability to psychiatric illnesses will have the potential to transform the field by providing insight into both biological and environmental determinants that contribute to serious developmental and psychiatric disorders in children and adolescents. These advances promise new understanding and new avenues for prevention and treatment. They will also present physicians and families with significant clinical and ethical challenges.
State
M W
MW
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-7900, USA.
Lombroso
P J
PJ
Pauls
D L
DL
Leckman
J F
JF
D002648:Child; D002874:Chromosome Mapping / Q000379:methods*; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D009154:Mutation; D010641:Phenotype; D013577:Syndrome