Familial cases of severe measles pneumonia.
We report two cases of severe measles pneumonia. Patient 1, a 17-year-old boy who contracted measles in the acute phase of infectious mononucleosis caused by Epstein-Barr virus (EBV), transmitted the disease to patient 2, his father. Both patients presented severe pneumonia with bilateral diffuse micronodular shadows. Diagnoses were established in both patients by antibody titers for measles and reverse transcriptase-polymerase chain reaction (RT-PCR) of blood and throat swab. Multinucleated giant cells with intranuclear inclusion bodies were revealed in the transbronchial lung biopsy (TBLB) specimen of patient 2. Both patients recovered with pulse steroid therapy.
Department of Internal Medicine, Kurashiki Central Hospital.
I
I
Ito
T
T
Ishida
T
T
Hashimoto
M
M
Arita
M
M
Osawa
C
C
Tsukayama
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications; D008297:Male; D008457:Measles / Q000150:complications / Q000175:diagnosis / Q000635:transmission*; D008459:Measles virus / Q000276:immunology / Q000302:isolation & purification; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000150:complications / Q000175:diagnosis*; D012367:RNA, Viral / Q000302:isolation & purification
D000914:Antibodies, Viral; D012367:RNA, Viral; D008775:Methylprednisolone