A PET study of adenosine A1 receptor in anesthetized monkey brain.
We demonstrated the distribution of adenosine A1 receptors in the anesthetized monkey brain with positron emission tomography (PET) using [(11)C]KF15372 ([1-propyl-(11)C]8-dicyclopropylmethyl-1, 3-dipropylxanthine). [(11)C]KF15372 was injected intravenously. The regional standardized uptake values and the distribution volume were calculated. We also investigated the effect of carrier on the uptake and regional brain distribution of [(11)C]KF15372. The use of [(11)C]KF15372 with dynamic PET scanning could be an appropriate method to analyze the regional binding potential of adenosine A1 receptors in living brain.
Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.
S
S
Wakabayashi
T
T
Nariai
K
K
Ishiwata
T
T
Nagaoka
K
K
Hirakawa
K
K
Oda
Y
Y
Sakiyama
S
S
Shumiya
H
H
Toyama
F
F
Suzuki
M
M
Senda
D000758:Anesthesia; D000818:Animals; D001923:Brain Chemistry; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D005260:Female; D008252:Macaca fascicularis; D018047:Receptors, Purinergic P1 / Q000032:analysis*; D014055:Tomography, Emission-Computed; D014970:Xanthines / Q000378:metabolism*
D002250:Carbon Radioisotopes; D018047:Receptors, Purinergic P1; D014970:Xanthines; C067197:8-(dicyclopropylmethyl)-1,3-dipropylxanthine