Potential risks of viral infections in xenotransplantation.
The shortage of cadaveric human organs for transplantation may, be alleviated by the use of xenografts as a therapeutic option for end-stage organ failure. Successful attempts have been made to prevent rejection of xenograft tissues in humans. The potential spread of animal-derived pathogens to the xenograft recipient is a complication of xenotransplantation, which must be addressed. This can be complicated further by, the presence of new pathogens, new clinical syndromes, and altered behaviour of these organisms in the immunocompromised recipient. There is concern over the possible activation of latent viruses, including retroviruses, from xenograft tissues. This paper discusses the possible dangers of transmission of animal viruses to humans via xenotransplantation.
Langat
D K
DK
Institute of Primate Research, National Museums of Kenya, Karen, Nairobi.
Mwenda
J M
JM
D000818:Animals; D020077:Endogenous Retroviruses / Q000472:pathogenicity; D006564:Herpesviridae / Q000472:pathogenicity; D006566:Herpesviridae Infections / Q000635:transmission; D006801:Humans; D016377:Organ Transplantation / Q000009:adverse effects*; D030361:Papillomavirus Infections / Q000635:transmission; D010215:Papio / Q000821:virology; D012192:Retroviridae Infections / Q000635:transmission; D012307:Risk Factors; D016097:Simian Acquired Immunodeficiency Syndrome / Q000635:transmission; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity; D013539:Simian virus 40 / Q000472:pathogenicity; D013552:Swine / Q000821:virology*; D014183:Transplantation, Heterologous / Q000009:adverse effects*; D014777:Virus Diseases / Q000635:transmission*; D014780:Viruses / Q000472:pathogenicity*