Antibiotic 26-deoxylaidlomycin isolated from Streptomyces sp. Ar386 from Brazilian soil.
An actinomycete strain (Ar386) was isolated from the soil of the Araraquara region, SP, Brazil. The strain, named Streptomyces jacareensis, formed irregular rayed, rugose, grayish-white mycelium with sinuous, branched hyphae carrying rare isolated spores; assimilated glucose, galactose, inositol, ribose, maltose, sucrose, melibiose and starch but not mannitol, rhamnose, arabinose, xylose, lactose and raffinose; and contained LL-diaminopimelic acid in its cell wall. An antibiotic active against Gram-positive bacteria, which was characterized as being 26-deoxylaidlomycin and which may have application against poultry coccidiosis, was isolated from cultures of the strain. This was the first isolation of this antibiotic from a microorganism of the genus Streptomyces and also the first isolation of this antibiotic in Brazil.
Faculdade de Ciências Farmacêuticas da Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP, Araraquara, SP, Brazil.
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Ujikawa
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Vilegas
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Vilegas
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Llabrés
D001938:Brazil; D008985:Monensin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification; D012988:Soil Microbiology; D013302:Streptomyces / Q000302:isolation & purification / Q000378:metabolism
C062367:26-deoxylaidlomycin; D008985:Monensin