[Treatment of malignant germ cell tumors of the ovary: a clinical analysis of 233 cases].
OBJECTIVE
To evaluate the treatment methods of malignant germ cell tumors of the ovary.


METHODS
Two hundred thirty three patients with malignant germ cell tumors of the ovary treated during 1958 through 1993 were retrospectively analyzed. The number of patients in different stage of the disease was as follows: stage I, 94; stage II-IV, 43; recurrence or metastasis, 96. Unilateral salpingo-oophorectomy was performed in 78 patients, or total abdominal hysterectomy and bilateral salpingo-oophorectomy with or without omentectomy and appendectomy was performed in 151 cases, and biopsy in 4 cases. Operation alone was done in 17 cases, operation plus radiotherapy with or without chemotherapy in 65, operation plus chemotherapy in 151 cases.


RESULTS
Of the 233 patients 127 were disease-free. The number of survivors in stage I patients was 78, in stage II-IV was 17. There were 32 cases with recurrence and metastasis. The overall 5-year survival rate was 55.6%. The 5-year survival rate differed between dysgerminoma and nondysgerminomatous tumurs being 84.2% for the former and 44.6% for the latter. In patients with nondysgerminomatous tumors, chemotherapy with PVB and BEP regimens gave a 5-year survival rate of 66.0% and 73.3%, respectively.


CONCLUSIONS
Malignant germ cell tumors of the ovary is very sensitive to chemotherapy. The PVB and BEP regimens result in excellent response in these patients. Complete remission and preservation of fertility can be obtained in patients with early tumors. Preoperative chemotherapy and postoperative adjuvant chemotherapy can improve survival in patients with advanced tumors.
Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
R
R
Zhang
W
W
Hong
L
L
Liu
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004407:Dysgerminoma / Q000188:drug therapy / Q000601:surgery; D018240:Endodermal Sinus Tumor / Q000188:drug therapy / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate; D013724:Teratoma / Q000188:drug therapy / Q000601:surgery