Primary effusion lymphoma with B-cell phenotype.
We describe here a case of primary effusion lymphoma that occurred in a 78-year-old woman. She was successively treated with prednisolone but died 15 months after the diagnosis of primary effusion lymphoma. The immunohistochemistry revealed the neoplastic cells to be CD19(+), CD20(+), CD21(+), Sm-Ig(+), and HLA-DR(+). This patient exhibited clonal IgH and clonal kappa light chain gene rearrangement, indicating a B-cell origin. The present case was distinguished from the majority cases of HHV-8-positive primary effusion lymphoma. Here we present clinical details of response to therapy in this case.
Iwahashi
M
M
Department of Internal Medicine, Saiseikai-Hita Hospital, Hita-Oita, Japan.
Iida
S
S
Sako
S
S
Inoue
S
S
Kikuchi
H
H
Otsuka
E
E
Nasu
M
M
D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D005260:Female; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D010490:Pericardial Effusion; D016066:Pleural Effusion, Malignant; D011239:Prednisolone / Q000627:therapeutic use
D015703:Antigens, CD; D018931:Antineoplastic Agents, Hormonal; D011239:Prednisolone