Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting.
The renin-angiotensin system (RAS) has a wide range of actions in biological processes ranging from development and reproduction to cardiovascular and renal functions. Most of these actions are mediated by the octapeptide hormone angiotensin II. The identified family of angiotensin II receptors is divided into two pharmacological classes: type 1 (AT1) and type 2 (AT2). The classically recognized actions of the RAS are primarily mediated by the AT1 subtype of angiotensin receptors, and these receptors are the targets of a new class of anti-hypertensive agents. In recent years, our understanding of the physiological functions of AT1 receptors has been advanced through the use of gene-targeting technology. In this review, we will summarize the emerging picture of AT1 receptor functions that has been provided by gene-targeting experiments.
Audoly
L P
LP
Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, 508 Fulton Street, Durham NC 27710, USA.
Oliverio
M I
MI
Coffman
T M
TM
D000804:Angiotensin II / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D018390:Gene Targeting; D006801:Humans; D007109:Immunity / Q000502:physiology; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000235:genetics* / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000235:genetics / Q000502:physiology
D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D000804:Angiotensin II