FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor flagellin in Arabidopsis.
Flagellin, the main protein of the bacterial flagella, elicits defence responses and alters growth in Arabidopsis seedlings. Previously, we identified the FLS1 locus, which confers flagellin insensitivity in Ws-0. To identify additional components involved in flagellin perception, we screened for flagellin insensitivity mutants in the flagellin-sensitive accession La-er. Here, we describe the identification of a new locus, FLS2, by a map-based strategy. The FLS2 gene is ubiquitously expressed and encodes a putative receptor kinase. FLS2 shares structural and functional homologies with known plant resistance genes and with components involved in the innate immune system of mammals and insects.
Gómez-Gómez
L
L
Friedrich Miescher-Institut, Basel, Switzerland. lourdes.gomez@fmi.ch
Boller
T
T
D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D029681:Arabidopsis Proteins; D003001:Cloning, Molecular; D005408:Flagellin / Q000494:pharmacology*; D020869:Gene Expression Profiling; D017343:Genes, Plant / Q000235:genetics; D005816:Genetic Complementation Test; D000090263:Leucine-Rich Repeat Proteins; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D030821:Plants, Genetically Modified; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016897:Respiratory Burst; D015398:Signal Transduction / Q000187:drug effects
D029681:Arabidopsis Proteins; D000090263:Leucine-Rich Repeat Proteins; D008565:Membrane Proteins; D010940:Plant Proteins; D011506:Proteins; D012333:RNA, Messenger; D005408:Flagellin; D011494:Protein Kinases; C411853:FLS2 protein, Arabidopsis