Malignant meningioma with rhabdoid transformation.
We report a rare case of recurrent meningioma with malignant change and rhabdoid transformation in a 54-year-old woman who presented with severe headache and progressive weakness of the right extremities. The patient had a history of atypical meningioma and had undergone a craniotomy to remove a tumor nine years earlier. We discuss the distinctive morphologic, immunohistochemical staining and ultrastructural features of a recurrent malignant meningioma. A meningioma with rhabdoid transformation may indicate aggressive biologic and clinical behavior of the tumor.
Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, National Defense University, Taipei, Taiwan, ROC.
W H
WH
Lee
A
A
Chen
D G
DG
Chao
H J
HJ
Harn
S Z
SZ
Lin
D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D008579:Meningioma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure
D005904:Glial Fibrillary Acidic Protein; D018396:Mucin-1