The use of naproxen in the treatment of children with rheumatic fever.
We evaluated the efficacy and safety of naproxen (10-20 mg/kg/d) for the treatment of arthritis and fever related to rheumatic fever in 19 children. Fever and arthritis resolved within a median of 1 day of beginning treatment (range, 1-2 and 1-30 days, respectively). The sole patient with prolonged arthritis had small joint involvement. No gastrointestinal, dermatologic, liver, or renal side effects were observed. None of the patients developed carditis over the following 6 months. Naproxen appears to be effective for the treatment of arthritis and fever related to rheumatic fever and is well tolerated.
Department of Pediatrics, Sapir Medical Center, Kfar-Saba, Israel.
Y
Y
Uziel
P J
PJ
Hashkes
E
E
Kassem
S
S
Padeh
R
R
Goldman
B
B
Wolach
B
B
Vollach
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009288:Naproxen / Q000627:therapeutic use*; D012189:Retrospective Studies; D012213:Rheumatic Fever / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen