Topical ketanserin gel for anal fissure: an open-label, prospective study.
This open-label, prospective study assessed the efficacy and safety of topical ketanserin gel in 63 patients with symptomatic anal fissure. The efficacy outcome was total clinical healing of the fissure. Topical ketanserin gel was 90% effective (fissure healed) and 100% safe (no adverse events) in the primary nonsurgical treatment of anal fissure.
Zielanowski
M M
MM
American/British Cowdray Medical Center, Mexico City, Mexico 01120, USA.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy*; D005782:Gels; D006801:Humans; D007650:Ketanserin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012702:Serotonin Antagonists / Q000627:therapeutic use*
D005782:Gels; D012702:Serotonin Antagonists; D007650:Ketanserin