[Steroids for prophylaxis of nephropathy in Schnlein Henoch purpura? Follow-up of 171 patients].
The necessity of the controversially discussed general steroid prophylaxis in Henoch-Schönlein Purpura (HSP) was analysed based on frequency, risk factors and prognosis of renal involvement. Case histories and follow up of at least 1.5 years were evaluated in all 171 patients (median age 6 years) in our institution suffering from HSP between 1.1.1987 and 30.6.1997. HSP was frequently manifest with an involvement of joints (64%) and gastrointestinal tract (58%). Renal involvement occurred in only 29% of the children. Excepted one girl (age 12 year), all children with renal disease completely recovered. Renal involvement was significantly rarer in young children (16%) and after one week therapy with prednisone (7%). In young children, renal involvement always followed abdominal pain.


CONCLUSIONS
In our collective, a general preventing of renal disease in HSP was unnecessary. Especially in young children, the most common manifestation age, renal involvement rarely occurred and had always a good prognosis.
Reinehr
T
T
Vestische Kinderklinik, Universität Witten-Herdecke.
Bürk
G
G
Berger
T
T
Doeker
B
B
Andler
W
W
D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications*; D015994:Incidence; D007223:Infant; D008297:Male; D009393:Nephritis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D011241:Prednisone