Combined chemoradiotherapy with daily low-dose cisplatin in locally advanced inoperable non-small cell lung cancer.
Sixty-one consecutive patients with locally advanced inoperable non-small-cell lung cancer were treated with chemoradiation with 60 Gy and concomitant daily low-dose cisplatin (6 mg/m(2)) in a single uninterrupted course. Toxicity was mild, 80% of patients were treated as outpatients. The median survival of 70 weeks compares favorably to the literature.
Biedermann
B
B
Department of Oncology, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland.
Landmann
C
C
Kann
R
R
Passweg
J
J
Solèr
M
M
Lohri
A
A
Rochlitz
C
C
Herrmann
R
R
Pless
M
M
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D011881:Radiotherapy, Computer-Assisted / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D016019:Survival Analysis
D011838:Radiation-Sensitizing Agents; D002945:Cisplatin