Focal cortical dysplasia of the temporal lobe with late-onset partial epilepsy: serial quantitative MRI.
We describe serial studies of focal cortical dysplasia causing temporal lobe seizures and progressive aphasia in a 54-year-old woman. Initially, MRI volumetry of the temporal lobes showed significant left cortical thickening corresponding to an elevated amino-acid uptake in the left temporoparietal and inferior frontal cortex on SPECT using 3-[123I]iodo-alpha-methyl-L-tyrosine (IMT). After 1 year there was severe shrinkage of the left temporal lobe, possibly the result of recurrent complex partial seizures.
Rademacher
J
J
Department of Neurology, Heinrich-Heine University, Düsseldorf.
Aulich
A
A
Reifenberger
G
G
Kiwit
J C
JC
Langen
K J
KJ
Schmidt
D
D
Seitz
R J
RJ
D001037:Aphasia / Q000175:diagnosis; D001284:Atrophy; D001931:Brain Mapping; D004828:Epilepsies, Partial / Q000175:diagnosis*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013702:Temporal Lobe / Q000002:abnormalities* / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon