Effect of Inula viscosa extract on chitin synthesis in dermatophytes and Candida albicans.
An antimycotic effect of an extract from Inula viscosa leaves was demonstrated affecting chitin synthesis in dermatophytes and Candida albicans. The antimycotic effect was compared to the effect caused by miconazole nitrate--an antifungal drug. The inhibition effect on chitin synthesis was not correlated to the extent of growth inhibition caused by the antifungal agents: both miconazole nitrate and the I. viscosa extract inhibited the growth of dermatophytes and C. albicans. Miconazole nitrate did not affect chitin synthesis--except for M. canis--whereas I. viscosa extract caused a significant decline in chitin content.
Department of Food Engineering and Biotechnology, Technion, 32000, Haifa, Israel. mmaoz1@inter.net.il
M
M
Maoz
I
I
Neeman
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects* / Q000378:metabolism; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D002686:Chitin / Q000096:biosynthesis*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D038143:Inula; D007444:Inulin; D010936:Plant Extracts / Q000494:pharmacology*
D000935:Antifungal Agents; D010936:Plant Extracts; D002686:Chitin; D007444:Inulin; D004121:Dimethyl Sulfoxide