[Telomerase activity in human primary endometrial carcinoma].
OBJECTIVE
To investigate the possible relationship between telomerase expression and progression of endometrial carcinoma.


METHODS
Thirty-four primary endometrial carcinoma and 6 normal endometrial tissue specimens were examined by means of telomeric repeat amplification protocol (TRAP) assay for telomerase activity.


RESULTS
Of 34 endometrial cancer specimens, 28 (82.4%) showed telomerase activity, whereas 1 of 6 (16.7%) benign endometrial tissues exhibited telomerase activity.


CONCLUSIONS
Telomerase expression might contribute to the progression of endometrial carcinoma and could be used as its tumor marker.
Cancer Hospital (Institute), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
C
C
Zhou
J
J
Sun
S
S
Jin
D000230:Adenocarcinoma / Q000201:enzymology*; D014408:Biomarkers, Tumor; D016889:Endometrial Neoplasms / Q000201:enzymology*; D005260:Female; D006801:Humans; D019098:Telomerase / Q000378:metabolism*
D014408:Biomarkers, Tumor; D019098:Telomerase