Changes of cytokines during the course of graft-versus-host disease following bone marrow transplantation: a case report.
Allogeneic bone marrow transplantation was performed in a 24-year-old woman with acute myelogenous leukemia in the first remission (FAB classification: M4). Graft-versus-host disease occurred from around day 150 after bone marrow transplantation. The levels of tumour necrosis factor-alpha, interleukin 12, and intercellular adhesion molecule-1 were elevated in the early stage of graft-versus-host disease, followed by elevation of interleukin 10 and interleukin 8. Her symptoms subsequently improved and all of these parameters became normal. The levels of thrombomodulin and plasminogen activator inhibitor type 1 showed changes that were in parallel with the clinical course. Interleukin 1beta, interleukin 6, interleukin 2, and interferon-gamma showed no changes throughout the course of her graft-versus-host disease. These findings suggested the possibility that release of inflammatory molecules occurred at the onset of graft-versus-host disease and caused vascular endothelial damage, which led to the exacerbation of her disease.
Second Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. hematol@hyo-med.ac.jp
H
H
Takatsuka
Y
Y
Takemoto
M
M
Okada
A
A
Sawada
T
T
Katsuno
H
H
Wada
E
E
Kakishita
D000328:Adult; D016026:Bone Marrow Transplantation; D015815:Cell Adhesion Molecules / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006086:Graft vs Host Disease / Q000378:metabolism*; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D018180:Thrombomodulin / Q000378:metabolism
D015815:Cell Adhesion Molecules; D018925:Chemokines; D016207:Cytokines; D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin