Synthesis of diaryl-substituted imidazo[l,2-a]pyridines designed as potential aromatase inhibitors.
From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.
Enguehard
C
C
Laboratoire de Chimie Thérapeutique, UFR des Sciences Pharmaceutiques, Tours, France,
Renou
J L
JL
Allouchi
H
H
Leger
J M
JM
Gueiffier
A
A
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014961:X-Ray Diffraction
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D007093:Imidazoles; D011725:Pyridines