Genetic alterations in human prostate cancer: a review of current literature.
We review the literature dealing with genetic alterations in human prostate cancer. We also discuss genetic predisposition and the roles of various proto-oncogenes and tumor-suppressor genes in prostate cancer initiation, progression, and metastasis. The role of telomere dynamics in prostate cancer metastasis and the induction of apoptosis is also briefly discussed.
Ozen
M
M
Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Pathak
S
S
D000230:Adenocarcinoma / Q000235:genetics*; D015703:Antigens, CD; D017209:Apoptosis; D002869:Chromosome Aberrations; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D017491:Genes, APC; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D051861:Kangai-1 Protein; D019656:Loss of Heterozygosity; D008297:Male; D008562:Membrane Glycoproteins; D009154:Mutation; D009857:Oncogenes; D011471:Prostatic Neoplasms / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D011519:Proto-Oncogenes; D019098:Telomerase / Q000235:genetics / Q000502:physiology; D016615:Telomere / Q000648:ultrastructure
D015703:Antigens, CD; C497688:CD82 protein, human; D004273:DNA, Neoplasm; D006133:Growth Substances; D051861:Kangai-1 Protein; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D019098:Telomerase