Microbial transformation of dehydropinguisenol by Aspergillus sp.
Two metabolites were obtained by microbial transformation of a furanosesquiterpene alcohol, dehydropinguisenol, using Aspergillus niger and Aspergillus cellulosae. Their structures were established as 10-oxo-lejeuneapinguisenol and lejeuneapinguisenol on the basis of their spectroscopic data. The latter compound was obtained after 4 and 9 days of incubation with A. cellulosae at 30 degrees C and 25 degrees C, respectively. Aspergillus niger produced both metabolites after 3 and 5 days incubation at 30 degrees C, respectively. A possible pathway for the formation of these compounds is discussed here together with their antimicrobial activity against A. niger and A. cellulosae.
Faculty of Pharmaceutical Science, Tokushima Bunri University, Japan.
E H
EH
Lahlou
Y
Y
Noma
T
T
Hashimoto
Y
Y
Asakawa
D001230:Aspergillus / Q000378:metabolism*; D001234:Aspergillus niger / Q000378:metabolism; D001711:Biotransformation; D007700:Kinetics; D019684:Magnoliopsida; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism*
D012717:Sesquiterpenes; C418383:dehydropinguisenol