Lipid peroxidation and antioxidant system in the blood of patients with Hodgkin's disease.
OBJECTIVE
The purpose of this study was to measure the extent of lipid peroxidation and the status of antioxidants in patients with Hodgkin's disease.


METHODS
Glutathione peroxidase (GPX) and superoxide dismutase (SOD) activities, and malondialdehyde (MDA), selenium, zinc and copper content have been measured in 20 patients with Hodgkin's disease and 30 age-matched controls.


RESULTS
Significantly higher concentrations of MDA in plasma as well as in erythrocytes were found compared to the control group. In both plasma and erythrocytes, GPX activity, selenium and zinc levels were significantly lower in patients than in controls. However, SOD activity in erythrocytes and copper levels in both plasma and erythrocytes were significantly higher in patients.


CONCLUSIONS
We conclude that the antioxidant system is impaired in Hodgkin's disease due to the abnormal metabolism of trace elements and antioxidant enzymes.
Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. mgguven@istanbul.edu.tr
M
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Güven
B
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Oztürk
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Sayal
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Ozet
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D004912:Erythrocytes / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D006689:Hodgkin Disease / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D013053:Spectrophotometry; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000097:blood; D014131:Trace Elements / Q000097:blood
D000975:Antioxidants; D014131:Trace Elements; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase