[A randomized trial of Zudan in the prophylaxis of nausea and vomiting induced by cisplatin].
OBJECTIVE
To study the anti-emetic effect of Zudan on high-dose cisplatin and its toxicity.


METHODS
A randomized, crossover assay was used in thirty patients who received cisplatin chemotherapy to compare the efficacy and the toxicity of identical dose of Zudan and Zofran.


RESULTS
The response rate of acute vomiting induced by cisplatin was 70.0% in patients receiving Zudan and 63.3% in those receiving Zofran. Complete response rate was 56.7% in Zudan arm and 53.3% in Zofran arm. The two arms were not remarkably different in response rates or adverse reactions.


CONCLUSIONS
Zudan is safe and effective in the control of vomiting induced by cisplatin.
Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
J
J
Huang
Z
Z
Wang
L
L
Zhou
D000293:Adolescent; D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D017294:Ondansetron / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000627:therapeutic use; D014840:Vomiting, Anticipatory / Q000139:chemically induced / Q000517:prevention & control*
D000932:Antiemetics; D000970:Antineoplastic Agents; D012702:Serotonin Antagonists; D017294:Ondansetron; D002945:Cisplatin