Acquired haemophilia complicating the remission of a patient with high grade non-Hodgkin's lymphoma treated by fludarabine.
We report the development of a high titre antibody to factor VIII in a patient with previous high grade B cell non-Hodgkin's lymphoma treated with fludarabine. Unlike previous reports of factor VIII inhibitors and lymphoproliferative disease this patient's lymphoma was in remission. We speculate that the occurrence of the inhibitor is another manifestation of the increasingly recognized autoimmune side-effects of fludarabine.
Department of Haematology, Royal Victoria Infirmary, Newcastle Upon Tyne, UK. c.w.tiplady@ncl.ac.uk
C W
CW
Tiplady
P J
PJ
Hamilton
M J
MJ
Galloway
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D015551:Autoimmunity; D003288:Contusions / Q000139:chemically induced / Q000276:immunology; D006467:Hemophilia A / Q000139:chemically induced* / Q000276:immunology; D006470:Hemorrhage / Q000139:chemically induced / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014740:Vidarabine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000276:immunology
D000970:Antineoplastic Agents; D001323:Autoantibodies; D007166:Immunosuppressive Agents; D014740:Vidarabine; C024352:fludarabine