Epithelial calcium channel: gate-keeper of active calcium reabsorption.
The epithelial calcium channel present in the apical membrane of 1,25-dihydroxyvitamin D3-responsive nephron segments represents the first member of a new family of calcium channels. This review covers the distinctive properties of this highly calcium-selective channel and highlights the implications for our understanding of the process of calcium reabsorption.
Department of Cell Physiology, University of Nijmegen, The Netherlands.
J G
JG
Hoenderop
D
D
Müller
M
M
Suzuki
C H
CH
van Os
R J
RJ
Bindels
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D019459:Urothelium / Q000502:physiology*
D015220:Calcium Channels; D002118:Calcium