Molecular evidence of ocular Epstein-Barr virus infection.
Ocular manifestations have been attributed to the Epstein-Barr virus (EBV), largely on the basis of seroepidemiologic data. Two patients who developed conjunctival disease as the presenting feature of EBV infection are reported, each confirmed by in situ hybridization of EBV genome in affected tissue biopsy specimens. Recognition of EBV-induced ocular disease as an initial presentation of clinical EBV infection is important to the practitioner because of the ubiquitous nature of this herpesvirus.
Departments of Infectious Diseases, St. Jude Children's Research Hospital, and Department of Pediatrics, University of Tennessee, Memphis, Tennessee, TN, USA. karen.slobod@stjude.org
K S
KS
Slobod
J T
JT
Sandlund
P H
PH
Spiegel
B
B
Haik
J L
JL
Hurwitz
M E
ME
Conley
L C
LC
Bowman
E
E
Benaim
J J
JJ
Jenkins
R M
RM
Stocks
Y
Y
Gan
J W
JW
Sixbey
D002648:Child; D002675:Child, Preschool; D003236:Conjunctivitis, Viral / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods
D004279:DNA, Viral