[The function of the liver mono-oxygenase system in a non-coronarogenic lesion of the heart muscle in an experiment].
The functional state was studied of the monooxygenase system in the liver in the time-related progression of izardine-induced myocarditis (IM) and allergic myocarditis (AM) in rats. In IM, the activity of monooxygenase enzymes (ME) was found to have gotten increased against the background of a decrease in the content of microsomal cytochromes, which event is believed to be secondary to a direct effect of izardine on the liver. In AM, a decline in ME activity appeared to correlate with a decrease in the content of microsomal cytochromes. This suggests a direct impact of cardiac pathology on the liver.
Rakhmatullaev
Sh S
ShS
Iuldashev
N M
NM
D000704:Analysis of Variance; D000707:Anaphylaxis / Q000201:enzymology / Q000209:etiology; D000818:Animals; D002316:Cardiotonic Agents; D004195:Disease Models, Animal; D007114:Immunization / Q000379:methods; D007545:Isoproterenol; D008297:Male; D008862:Microsomes, Liver / Q000737:chemistry / Q000201:enzymology*; D009205:Myocarditis / Q000139:chemically induced / Q000201:enzymology*; D010105:Oxygenases / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D002316:Cardiotonic Agents; D010105:Oxygenases; D007545:Isoproterenol