Osteoarticular disorders of renal origin: disease-related and iatrogenic.
Osteoarticular disorders significantly limit the quality of long-term survival with chronic renal failure. beta 2M amyloidosis is a complication of chronic renal failure that has been recognized mostly in patients receiving long-term haemodialysis. Patients with beta 2M amyloidosis typically present with the triad of shoulder periarthritis, carpal tunnel syndrome, and flexor tenosynovitis of the hands. Other musculoskeletal manifestations of beta 2M amyloidosis include destructive spondyloarthropathy, cervico-occipital pseudotumours, bone cysts, and pathological fractures. At present, only renal transplantation may slow or halt the progession of beta 2M amyloidosis. Crystal-induced arthropathy, most commonly caused by basic calcium phosphate crystals, is an important cause of acute joint inflammation in the patient with renal failure. The incidence of bone and joint infection is increased in patients undergoing dialysis. Haemodialysis and peritoneal dialysis are also associated with an erosive or destructive arthropathy of finger joints, which is not explained by local amyloid deposition.
Department of Internal Medicine, Lahey Clinic Medical Center, Burlington, Massachusetts, USA.
J
J
Kay
T
T
Bardin
D000686:Amyloidosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007049:Iatrogenic Disease; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D010003:Osteoarthritis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D006435:Renal Dialysis / Q000009:adverse effects; D001613:beta 2-Microglobulin / Q000378:metabolism
D001613:beta 2-Microglobulin