Surface plasmon resonance analysis of dynamic biological interactions with biomaterials.
Surface plasmon resonance (SPR) is an optical technique that is widely gaining recognition as a valuable tool to investigate biological interactions. SPR offers real time in situ analysis of dynamic surface events and, thus, is capable of defining rates of adsorption and desorption for a range of surface interactions. In this review we highlight the diversity of SPR analysis. Examples of a wide range of applications of SPR are presented, concentrating on work relevant to the analysis of biomaterials. Particular emphasis is given to the use of SPR as a complimentary tool, showing the broad range of techniques that are routinely used alongside SPR analysis.
Green
R J
RJ
Laboratory of Biophysics and Surface Analysis, School of Pharmaceutical Sciences, The University of Nottingham, University Park, UK. r.green@surrey.ac.uk
Frazier
R A
RA
Shakesheff
K M
KM
Davies
M C
MC
Roberts
C J
CJ
Tendler
S J
SJ
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics; D001698:Biomedical Engineering; D004247:DNA / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D011506:Proteins / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000379:methods*; D013499:Surface Properties; D018406:Virus Physiological Phenomena
D001672:Biocompatible Materials; D011506:Proteins; D004247:DNA