[3-hydroxy-3-methylglutaraciduria (case report of a female Turkish sisters with 3-hydroxy-3- methylglutaryl-Coenzyme A lyase deficiency].
3-Hydroxy-3-methylglutaric aciduria is a rare inborn error of metabolism, caused by reduced enzyme activity of the intramitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase. We describe two turkish sisters with this disease. In the older sister clinical symptoms with lethargy, convulsions, metabolic acidosis, hypoglycemia and hyperammonemia lead to the diagnosis. The younger sister was diagnosed prenatally. The clinical course of our patients is compared with those reported in the literature with respect to clinical symptoms, differential diagnosis and therapeutic regimens.
Koling
S
S
Kinderklinik der Städtischen Kliniken Dortmund.
Kalhoff
H
H
Schauerte
P
P
Lehnert
W
W
Diekmann
L
L
D000138:Acidosis / Q000209:etiology; D003241:Consanguinity; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007231:Infant, Newborn; D015093:Meglutol / Q000652:urine*; D008661:Metabolism, Inborn Errors / Q000150:complications / Q000175:diagnosis* / Q000201:enzymology* / Q000652:urine; D008928:Mitochondria / Q000201:enzymology; D007652:Oxo-Acid-Lyases / Q000172:deficiency* / Q000235:genetics; D011296:Prenatal Diagnosis; D000644:Quaternary Ammonium Compounds / Q000097:blood; D012640:Seizures / Q000209:etiology; D012894:Sleep Stages; D014421:Turkey / Q000208:ethnology
D000644:Quaternary Ammonium Compounds; D015093:Meglutol; D007652:Oxo-Acid-Lyases; C021410:3-hydroxy-3-methylglutaryl-coenzyme A lyase