The role of calbindin and 1,25dihydroxyvitamin D3 in the kidney.
The identification of a putative apical Ca++ channel in 1,25dihydroxyvitamin D3 responsive epithelia (proximal intestine and the distal nephron) as well as recent studies using calbindin-D28k knock-out mice indicating the first direct in-vivo evidence for a role for this calcium-binding protein in renal calcium absorption suggest mechanisms, which had remained incomplete, related to the control of renal calcium absorption.
Sooy
K
K
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA.
Kohut
J
J
Christakos
S
S
D000818:Animals; D064092:Calbindin 1; D064026:Calbindins; D002117:Calcitriol / Q000494:pharmacology / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D064030:S100 Calcium Binding Protein G / Q000235:genetics / Q000502:physiology*; D019459:Urothelium / Q000502:physiology*
C576498:CALB1 protein, human; C576499:Calb1 protein, mouse; D064092:Calbindin 1; D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D002117:Calcitriol; D002118:Calcium