Antimetastatic action of a new analog of dacarbazine in mice bearing Lewis lung carcinoma.
We report the selective antimetastatic properties of 3-(3,3-dimethyl-1-triazenyl)-5-methyl-4,5-dihydroisoxazole in the murine transplantable tumor model Lewis lung carcinoma. The compound verifies a previous study on the correlation of antimetastatic, antitumor and cytotoxic properties of aryl- and heteroaryltriazenes with their Electron Ionization Mass Spectrometry (EI-MS) behavior. The new analog of dacarbazine exhibits a selective antimetastatic activity accompanied by limited thymus toxicity. The mechanism of action is unclear nevertheless any antiproliferative or cytotoxic effect is excluded.
Perissin
L
L
Department of Biomedical Sciences and Technologies, University of Udine, Italy. LPerissin@makek.dstb.uniud.it
Facchin
P
P
Bedini
A
A
Diamantini
G
G
Tontini
A
A
Tarzia
G
G
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000556:secondary; D002455:Cell Division / Q000187:drug effects; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D014226:Triazenes / Q000494:pharmacology*
C412012:3-(3,3-dimethyl-1-triazenyl)-5-methyl-4,5-dihydroisoxazole; D018906:Antineoplastic Agents, Alkylating; D014226:Triazenes; D003606:Dacarbazine