Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism, coronary thrombosis, and myocardial infarction in middle-aged Finnish men who died suddenly.
High plasminogen activator inhibitor-1 (PAI-1) plasma levels increase future risk of myocardial infarction (MI). The 4G allele of the 4G/5G polymorphism of the PAI-1 gene has been associated with increased plasma levels of PAI-1. The association of the PAI-1 polymorphism with coronary narrowings, coronary thrombosis and myocardial infarction (MI) was studied in a prospective autopsy series of 300 middle-aged Caucasian Finnish men (33 to 69 yrs) suffering sudden out-of-hospital death (Helsinki Sudden Death Study). The 4G allele was found in 76.8% of men with sudden cardiac death (SCD) compared to 67.5% in men who died accidentally and 63.2% in men who died of other diseases (p = 0.08 and p = 0.055, respectively). Men possessing the 4G allele had more often acute MI (OR 3.5; p <0.05) and coronary thrombosis (OR 5.5. p = 0.01) compared to 5G homozygotes. 5G homozygotes, comprising one third of the men in our study, seem to be at a decreased risk of thrombosis, whereas carriers of the common 4G allele have an increased risk of thrombosis, AMI and possibly SCD compared to 5G homozygotes.
Mikkelsson
J
J
Medical School, University of Tampere and Tampere University Hospital, Finland. jm56215@uta.fi
Perola
M
M
Wartiovaara
U
U
Peltonen
L
L
Palotie
A
A
Penttilä
A
A
Karhunen
P J
PJ
D000059:Accidents / Q000401:mortality; D000483:Alleles; D001344:Autopsy; D002423:Cause of Death; D015897:Comorbidity; D003327:Coronary Disease / Q000150:complications / Q000473:pathology; D003328:Coronary Thrombosis / Q000235:genetics / Q000401:mortality*; D003331:Coronary Vessels / Q000473:pathology; D003645:Death, Sudden / Q000453:epidemiology*; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics / Q000401:mortality*; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012306:Risk; D012907:Smoking / Q000453:epidemiology; D013405:Suicide / Q000706:statistics & numerical data
D017395:Plasminogen Activator Inhibitor 1