An unexpected and serious complication of treatment with the atypical antipsychotic drug clozapine.
A 49-year-old man developed acute renal failure due to interstitial nephritis during treatment with the drug clozapine. Referral and diagnosis were delayed through a failure to consider complications of treatment other than neuroleptic malignant syndrome. Although this association has not previously been reported in the literature, we include details of a further 7 cases of acute renal failure in association with clozapine therapy reported to the Committee On Safety Of Medicines in the UK.
Fraser
D
D
Elidir Renal Unit, Bangor, UK.
Jibani
M
M
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis
D014150:Antipsychotic Agents; D003024:Clozapine