Problems associated with the study of cellular oscillations.
Data from the article by Brodsky et al. (2000) have been examined in order to confirm that the fluctuations they report are not random but have a rhythmic basis, thereby verifying their conclusions regarding the existence of periodicity in protein synthesis. Reasons are outlined why oscillations should be expected in all cellular biochemical studies. Associated practical problems are briefly discussed together with comments on the validity and value of less rigorous methods of analysis. The subject of aliasing is raised as justification for doubting the validity of much published data, especially where periodicity has not been suspected. The existence of oscillations indicates the need for a thorough re-evaluation of our understanding of cell biochemistry.
Gilbert
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D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D003627:Data Interpretation, Statistical; D007527:Isoenzymes / Q000378:metabolism; D015233:Models, Statistical; D010507:Periodicity; D012107:Research Design; D012494:Sampling Studies; D015983:Selection Bias; D013997:Time Factors
D007527:Isoenzymes