UVA and UVB wavebands modulate expression of fasL in mouse skin epidermis.
In our previous report, we observed different cytokine modulation in mouse epidermis by the UVA and UVB wavebands. In the present investigations, the effects of irradiation with UVA and UVB on the Fas(CD95)/FasL system have been studied because apoptosis mediated by the interaction between Fas and FasL has been suggested recently to be associated with UVB-induced immunosuppression in mouse skin. Our results show that UVA irradiation following UVB irradiation has the ability to reduce the up-regulation of FasL expression in mouse skin resulting from the UVB irradiation.
Department of Veterinary Anatomy and Pathology, University of Sydney, New South Wales, Australia.
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J
Shen
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S
Bao
V E
VE
Reeve
D000818:Animals; D004817:Epidermis / Q000378:metabolism / Q000528:radiation effects*; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors; D014466:Ultraviolet Rays; D019014:fas Receptor
D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D019014:fas Receptor