[Polymorphism of trinucleotide CAG-repeats of the first exon of the androgen receptor gene in the Tomsk population].
Polymorphism of the CAG repeat of exon 1 of the androgen receptor (AR) gene was analyzed in the Tomsk population. In total, 12 alleles varying in size from 285 to 318 bp (21-32 CAG units) were revealed. The allele frequency distribution did not differ from the normal one. No difference in allele frequencies was detected between men and women of the same generation. The observed heterozygosity was equal to the expected one (0.88 +/- 0.03). Compared with other populations, the Tomsk population displayed a narrower allele spectrum and a bias of the most common allele to a greater repeat number. The results obtained may reflect specific population genetic processes characteristic of young developing populations.
Research Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Russia. victory@img.tsu.ru
V N
VN
Evdokimova
E A
EA
Putintseva
S A
SA
Nazarenko
D005091:Exons; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D012426:Russia; D018911:Trinucleotide Repeats
D011944:Receptors, Androgen