[Study on the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer].
OBJECTIVE
To investigate the correlation between CT features and expression of p53 protein and PCNA in peripheral lung cancer.


METHODS
The expression of p53 protein and PCNA was examined by means of SP immunohistochemical technique in 32 cases of peripheral lung cancer proved by pathology; the relationship between the results and preoperative CT features was analyzed retrospectively.


RESULTS
The expression of p53 protein and PCNA was correlated with tumor size, deep lobulation, frank cavitation, pleural indentation and mediastinal lymph node metastasis, but not with spiculation.


CONCLUSIONS
The CT features of peripheral lung cancer with diameter more than 3 cm, deep lobulation, frank cavitation, pleural indentation or mediastinal lymph node metastasis indicate higher degree of malignancy and proliferative activity of tumor cells.
Chen
J
J
Department of Interventional Radiology, Tangdu Hospital, Fourth Military Medical University, Xian.
Zhang
H
H
Huang
X
X
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D014057:Tomography, X-Ray Computed; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53