Hemostatic alterations in beta-thalassemia/hemoglobin E patients.
To search for evidence of coagulation activation ex vivo, the levels of human prothrombin fragment 1+2 (F1+2) were examined in 69 beta-thalassemia/Hb E patients. Levels of protein C inhibitor (PCI) and activated protein C - PCI (APC:PCI) complex were also determined in 9 of the above patients in conjunction with protein C (PC) antigen and activity, in an attempt to detect increased consumption of PC. In mean level of F1+2, there was a statistically significant difference between normal control and post-splenectomized patients (p < 0.05) but not between normal control and non-splenectomized patients (p > 0.05). The mean levels of PC activity and PC antigen in the patients were much lower than in normal controls. However, the mean levels of PCI and the mean level of APC:PCI complex in the patients were not significantly different from those in normal controls (p > 0.05). The high level of F1+2 in post-splenectomized patients found in this study agreed well with clinical and other laboratory findings. The normal level of PC inhibitor and APC:PCI complex found in this study provided no evidence of increased consumption of protein C in thalassemia patients.
Department of Clinical Pathology, Siriraj Hospital. Bangkok, Thailand.
N
N
Opartkiattikul
N
N
Tatsumi
Y
Y
Funahara
A
A
Shirahata
W
W
Wongtiraporn
P
P
Tientadakul
S
S
Fucharoen
D000328:Adult; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000097:blood* / Q000150:complications; D006801:Humans; D007564:Japan; D008297:Male; D010446:Peptide Fragments / Q000097:blood; D011486:Protein C / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D013156:Splenectomy; D017086:beta-Thalassemia / Q000097:blood* / Q000150:complications
D010446:Peptide Fragments; D011486:Protein C; D011516:Prothrombin; D006446:Hemoglobin E