Acute pancreatitis during immunosuppression with tacrolimus following an allogeneic umbilical cord blood transplantation.
Tacrolimus is increasingly used for graft-versus-host disease (GVHD) prophylaxis and therapy in the allogeneic stem cell transplant (allo-SCT) setting. Pancreatitis, previously described as a side-effect of cyclosporine, has not been reported in allo-SCT recipients receiving tacrolimus. We present here a case of acute pancreatitis in a 28-year-old patient with chronic myelogenous leukemia (CML) who received an unrelated umbilical cord blood transplant (UCBT) and tacrolimus for GVHD prophylaxis. On day +31 post-transplant, she developed severe acute pancreatitis with multiorgan failure, from which she recovered completely. Tacrolimus was the probable cause of pancreatitis in this patient.
Nieto
Y
Y
University of Colorado Bone Marrow Transplant Program, Denver, CO 80262, USA.
Russ
P
P
Everson
G
G
Bearman
S I
SI
Cagnoni
P J
PJ
Jones
R B
RB
Shpall
E J
EJ
D000328:Adult; D005260:Female; D005312:Fetal Blood; D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000628:therapy; D010195:Pancreatitis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D006435:Renal Dialysis; D016559:Tacrolimus / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous / Q000276:immunology*
D007166:Immunosuppressive Agents; D016559:Tacrolimus