Renal tubular effects of endothelin-B receptor signaling: its role in cardiovascular homeostasis and extracellular volume regulation.
The role of the endothelin-B receptor in vascular homeostasis is controversial because the receptor has both pressor and depressor effects in vivo. One potential depressor mechanism of endothelin-B activation is through the promotion of natriuresis and diuresis in the renal tubule. Recent studies demonstrate that rodents genetically deficient for the endothelin-B exhibit sodium-dependent hypertension due to an absence of tonic inhibition of the epithelial sodium channel in the distal nephron. These studies suggest that the predominant role of endothelin-B receptors in the basal physiologic state may be to regulate renal sodium excretion relative to the level of oral salt intake.
Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, USA.
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Ohuchi
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Yanagisawa
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Gariepy
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D005110:Extracellular Space / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology* / Q000503:physiopathology; D008954:Models, Biological; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin / Q000502:physiology*; D015398:Signal Transduction; D014882:Water-Electrolyte Balance
D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin