[Tissue engineering: possibilities and perspectives].
Successful tissue engineering requires intensive co-oporation between clinicians, biologists (cell culture, gene therapy), chemical engineers (biomaterials) and industrial partners. In case of wound healing tissue engineered constructs have already been applied successfully in burns and chronic wounds. In order to improve carrier and matrix function biomaterials still have to be optimized. The potential of such constructs might even be enhanced by gene therapeutical methods. The complex mammalian organism has to be considered as the gold standard and the model for perfect tissue engineering. The problem of vascularization of complex organs yet has to be solved. In general it seems to be more promising to substitute deficient components in vivo and to rely on modulating influences within the host organism rather than to create complex organs ex vivo.
Abteilung Plastische und Handchirurgie, Universitätsklinikum, Freiburg im Breisgau. stark@ch11.ukl.uni-freiburg.de
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D000818:Animals; D001672:Biocompatible Materials; D002056:Burns / Q000601:surgery / Q000628:therapy; D002478:Cells, Cultured; D002908:Chronic Disease; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage; D005500:Follow-Up Studies; D015316:Genetic Therapy; D006133:Growth Substances / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000637:transplantation*; D007871:Leg Ulcer / Q000601:surgery / Q000628:therapy; D051379:Mice; D016038:Skin Transplantation; D017768:Skin, Artificial; D013997:Time Factors; D014182:Transplantation, Autologous; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000601:surgery / Q000628:therapy*
D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; D006133:Growth Substances