Current concepts in androgen deprivation therapy--is there a "best" endocrine treatment?
Androgen deprivation therapy has become the mainstay treatment for locally advanced and metastatic prostate cancer. Castrate testosterone levels can be achieved by a multitude of treatments. We performed a medline literature search to answer the question, is there a "best" endocrine treatment? In conclusion we found that the "best" endocrine therapy for advanced prostate cancer is complete androgen blockade (CAB) with a luteinizing hormone-releasing hormone (LHRH) agonist and a nonsteroidal antiandrogen.
Gheiler
E L
EL
Department of Urology, University of Miami School of Medicine, Sylvester Comprehensive Cancer Institute, Florida, USA. egheiler@med.miami.edu.
Tiguert
R
R
D000726:Androgen Antagonists / Q000627:therapeutic use*; D005544:Forecasting; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006801:Humans; D008297:Male; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000601:surgery
D000726:Androgen Antagonists; D007987:Gonadotropin-Releasing Hormone