Influence of the -675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden.
Elevated plasminogen activator inhibitor 1 (PAI-1) levels are associated with venous thromboembolism, although their significance is unclear. PAI-1 levels are influenced by a PAI-1 promoter dimorphism (4G/5G), the 4G allele being associated with increased PAI-1 activity. We investigated whether the 4G allele influenced thrombotic risk by studying 99 symptomatic factor V (FV) Leiden heterozygotes and 99 healthy subjects. The 4G allele was more prevalent among cases than among healthy subjects (chi2 = 8.00, P = 0.005) and the odds ratio (OR) for thrombosis associated with either heterozygosity or homozygosity for the 4G allele was 2.43 (P = 0. 011). We conclude that carriership of the 4G allele was more prevalent in patients who already carried factor V Leiden than in control subjects without factor V Leiden.
Division of Molecular and Genetic Medicine, University of Sheffield Faculty of Medicine, Royal Hallamshire Hospital, Sheffield, UK.
J M
JM
Visanji
J
J
Seargent
D
D
Tahri
S A
SA
Croft
M
M
Makris
F E
FE
Preston
I R
IR
Peake
M E
ME
Daly
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D005165:Factor V; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D012306:Risk; D019851:Thrombophilia / Q000097:blood / Q000235:genetics*
D017395:Plasminogen Activator Inhibitor 1; C095381:factor V Leiden; D005165:Factor V