Synthesis of aminophosphonate haptens for an aminoacylation reaction between methyl glucoside and a beta-alanyl ester.
Two 2-aminophosphonate haptens derived from methyl alpha-D-glucopyranoside were synthesized to mimic the transition-state of a transesterification reaction between methyl alpha-D-glucopyranoside and 4-nitrophenylester of tert-BOC-beta-alanine. Two sets of monoclonal antibodies were generated against these haptens.
VTT Technical Research Centre of Finland, Chemical Technology, Espoo.
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Lintunen
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JT
Yli-Kauhaluoma
D000215:Acylation; D000588:Amines / Q000737:chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D004952:Esters; D005960:Glucosides / Q000737:chemistry*; D006241:Haptens / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D015091:beta-Alanine / Q000737:chemistry*
D000588:Amines; D004952:Esters; D005960:Glucosides; D006241:Haptens; D063065:Organophosphonates; D015091:beta-Alanine