[The effect of antibiotic preparations and their combinations with probiotics on the intestinal microflora of mice].
Antibiotic drugs (biseptol, polymyxin, canamycin) as well as their combinations with probiotics biosporin and subalin have been studied for their effect on mice intestine microflora. It has been established that under peroral administration of the above drugs dysbacteriosis of the 2-3rd degrees arises in animals; under their combined use with probiotics one can prevent the development of dysbacteriosis to considerable extent. It has been shown that dysbacteriosis of the 2-3rd degrees can be liquidated for 5-7 days, using probiotics biosporin and subalin. No self-recovery of normal intestinal microbiocenosis is observed in this period. Inconsiderable variations in the composition of normoflora under combined use of antibiotics with probiotics are renewed on the 3-5th day after stopping the drugs intake.
Taras Shevchenko Kyiv National University, Biological Faculty, Ukraine.
T M
TM
Furzikova
I B
IB
Sorokulova
M H
MH
Serhiĭchuk
S V
SV
Sichkar
V V
VV
Smirnov
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis; D001685:Biological Factors / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D007422:Intestines / Q000187:drug effects* / Q000382:microbiology*; D007612:Kanamycin / Q000494:pharmacology*; D051379:Mice; D011113:Polymyxins / Q000494:pharmacology*; D019936:Probiotics / Q000494:pharmacology*; D013997:Time Factors; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001685:Biological Factors; D011113:Polymyxins; C091592:biosporin; C112120:subalin; D007612:Kanamycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination