Administration of recombinant follicle stimulating hormone in a woman with allergic reaction to menotropin: a case report.
This report describes a patient who experienced a generalized allergic reaction to Pergonal during controlled ovarian hyperstimulation in preparation for an intracytoplasmic sperm injection procedure for treatment of severe male factor infertility. The report describes a successful desensitization protocol which allowed the patient to complete her treatment cycle despite the allergic reaction to Pergonal. Subsequently recombinant follicle stimulating hormone was used successfully in inducing follicular growth in the absence of any allergic reactions. Therefore, this report confirms other studies which have suggested that an allergic reaction to human menopausal gonadotropins is due to impurities in such urine-derived products.
Michigan State University, College of Human Medicine, Flint, USA.
S
S
Harrison
T
T
Wolf
M I
MI
Abuzeid
D000328:Adult; D004342:Drug Hypersensitivity; D004624:Embryo Transfer; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D043373:Follicle Stimulating Hormone, Human; D006801:Humans; D007246:Infertility / Q000628:therapy; D016729:Leuprolide / Q000627:therapeutic use; D008297:Male; D008596:Menotropins; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D011274:Pregnancy, Tubal; D011994:Recombinant Proteins / Q000627:therapeutic use*; D020554:Sperm Injections, Intracytoplasmic; D014463:Ultrasonography
D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; D008596:Menotropins; D005640:Follicle Stimulating Hormone; D016729:Leuprolide