Nervous system cancer mortality in an industrialized area of Brazil 1980-1993.
OBJECTIVE
The industrialization process and nervous system cancer (NSC) mortality in a urban region of Brazil.


METHODS
From registries of the State System of Data Analysis Foundation (SEADE), 103 males deaths by NSC (ICD-9) in Baixada Santista (BS), from 1980 to 1993 were selected. Mortality ratios were calculated comparing the standardized mortality rate for ages over 10 years old (G1) and for the age group from 35 to 64 years old, in the industrialized and non-industrialized areas in three periods: 1980-1993, 1980-86, 1987-93.


RESULTS
A statiscally significant high mortality was observed in the industrialized area, for ages over 10 in all periods and only from 1980 to 1993 for ages from 34 to 64. The highest mortality ratio occurred from 1980-86 for ages over 10 - 4.12 (CI 1.79-9.42).


CONCLUSIONS
High mortality was probably related to the environmental and occupational exposure to many organic and inorganic chemical substances, considered carcinogenics, such as aliphatic and aromatic hydrocarbons, organochlorinated, formaldehyde, nitrogenated compounds and heavy metals, found in the port and industrial complex. We discuss the importance of case-control studies in characterizing the association of these and other risk factors in the determination of NSC.
Medrado-Faria
M D
MD
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil.
de Almeida
J W
JW
Zanetta
D M
DM
Gattás
G J
GJ
D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002273:Carcinogens / Q000009:adverse effects; D002648:Child; D006801:Humans; D007221:Industry; D008297:Male; D008875:Middle Aged; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000401:mortality*; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D016273:Occupational Exposure; D012307:Risk Factors; D014504:Urban Health
D002273:Carcinogens