Effect of diacetylmonoxime on blood enzymes in fenitrothion-dosed buffalo calves.
The effect of iv diacetylmonoxime (DAM) alone or in combination with atropine was determined on blood enzymatic activities in fenitrothion-exposed buffalo calves. Fenitrothion given po at 435 mg/kg bw produced pronounced inhibition of blood acetylcholinesterase (AChE) and elevation in serum aspartate and alanine aminotransferases, acid and alkaline phosphatases, and lactate dehydrogenase within 30 min. The administration of DAM alone or in combination with atropine significantly reactivated AChE activity. The administration of DAM + atropine decreased serum aspartate and alanine aminotransferase enzymes within 1-3 d. The reversal effect of DAM + atropine on serum phosphatases and lactate dehydrogenase was greater than that of DAM or atropine alone.
Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
A K
AK
Srivastava
J K
JK
Malik
D000110:Acetylcholinesterase / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects; D000410:Alanine Transaminase / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects; D000818:Animals; D001219:Aspartate Aminotransferases / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects; D001285:Atropine / Q000494:pharmacology; D002020:Buffaloes / Q000097:blood*; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D003931:Diacetyl / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005278:Fenitrothion / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000187:drug effects; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D010744:Phosphoric Monoester Hydrolases / Q000097:blood / Q000187:drug effects
D002801:Cholinesterase Reactivators; D007306:Insecticides; D010276:Parasympatholytics; C004717:diacetylmonoxime; D001285:Atropine; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000110:Acetylcholinesterase; D010744:Phosphoric Monoester Hydrolases; D003931:Diacetyl; D005278:Fenitrothion