Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents.
Peptide deformylase was discovered 30 years ago, but as a result of its unusually unstable activity it was not fully characterized until very recently. The aim of this paper is to review the many recent data concerning this enzyme and to try to assess its potential as a target for future antimicrobial drugs.
Giglione
C
C
Institut des Sciences Végétales, UPR40, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
Pierre
M
M
Meinnel
T
T
D000581:Amidohydrolases; D000626:Aminopeptidases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans
D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D000626:Aminopeptidases; D000581:Amidohydrolases; C084507:peptide deformylase