Prognostic influence of p53 nuclear overexpression in colorectal carcinoma.
OBJECTIVE
The aim of this study was to test the prognostic influence of p53 nuclear overexpression in colorectal carcinoma.


METHODS
We performed an analysis of the prognostic influence of the nuclear overexpression of p53 with immunohistochemistry in 126 cases of colorectal carcinoma operated on in our hospital between 1987 and 1992, with a minimum follow-up time of 60 months (5 years).


RESULTS
Our results show a statistically significant prognostic influence of p53 overexpression on disease-free survival time, but not on the overall survival time, in univariate analysis, but this influence is lost in multivariate analysis.


CONCLUSIONS
Our results confirm recent reports by other authors that failed to show the independent prognostic value of p53 in colorectal carcinoma.
Hospital de la Fuenfría, Cercedilla, Spain.
M G
MG
Gallego
M J
MJ
Aceñero
S
S
Ortega
A A
AA
Delgado
J L
JL
Cantero
D000230:Adenocarcinoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D000368:Aged; D002467:Cell Nucleus / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53