Genetic variation and relationships at five STR loci in five distinct ethnic groups in China.
Five short tandem repeat (STR) systems of TH01, vWA, LPL, F13B and FES/FPS were investigated in five ethnic groups living in China (Tujia, Miao, Bai, Chaoxian and Han). All five loci did not deviate from the Hardy-Weinberg equilibrium (P>0.05). At the five loci of each ethnic group, the observed heterozygosity, the mean exclusion chance (MEC), and the power of discrimination (PD) ranged from 0.42 to 0.86, from 0.20 to 0.66 and from 0.61 to 0.95, respectively. For the five ethnic groups, the combined MEC and combined PD were >0. 9360 and >0.9998, respectively, suggesting that combinations of these five systems are feasible for DNA typing in forensic investigations such as personal identification or paternity testing. Furthermore, the allelic frequencies at the five loci suggested that these five ethnic groups were distinctly different communities. Judging from the phylogenetic tree constructed based on the genetic distance among the five ethnic groups, Han, Chaoxian and Tujia were involved in an identical cluster, and Miao and Bai in another. These findings indicate that each of the five groups examined is not only a distinct community, but also has a relationship with each of the others.
Department of Legal Medicine, Faculty of Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920-8640, Kanazawa, Japan. legal@med.kanazawa-u.ac.jp
Z
Z
Lin
T
T
Ohshima
S
S
Gao
T
T
Kondo
T
T
Takayasu
Y
Y
Sato
K
K
Sun
D000483:Alleles; D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D002681:China; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005240:Feasibility Studies; D005554:Forensic Medicine; D005784:Gene Amplification; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics*; D005858:Germany; D006579:Heterozygote; D006801:Humans; D007564:Japan; D010334:Paternity; D020080:Tandem Repeat Sequences / Q000235:genetics*; D044465:White People / Q000235:genetics
D004247:DNA