P300 as an index of recognition in a standard and difficult match-to-sample test: a model of amnesia in normal adults.
Earlier research has supported the use of a P300 (P3)-based procedure to detect simulated amnesia. In the present experiment, an attempt was made to model the behavior and event-related potentials (ERPs) that amnestic patients might demonstrate with relatively easy recognition memory tests, by increasing the difficulty of a match-to-sample recognition memory test taken by 18 memory-unimpaired undergraduates. None of the participants in the modeled amnesic condition were classified as having intact recognition memory as the result of P3-based intra-individual tests (specificity = 100%). The results support the utility of a P3 procedure for the detection of malingering by demonstrating the procedure to be a valid measure of impaired recognition with this model of amnesia.
Northwestern University, Evanston, IL, USA. jellwanger@ucsd.edu
J
J
Ellwanger
J P
JP
Rosenfeld
B L
BL
Hankin
J J
JJ
Sweet
D000328:Adult; D000647:Amnesia / Q000175:diagnosis* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D004193:Discrimination Learning / Q000502:physiology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008306:Malingering / Q000175:diagnosis* / Q000503:physiopathology; D011939:Mental Recall / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011237:Predictive Value of Tests