[The role of growth factors in wound healing].
Growth factors are mediators with essential importance for undisturbed repair process after wounding. The well coordinated concert of these substances is necessary for healing with complete restoration of function and morphology. These complex mechanisms are disturbed during secondary and delayed repair. The result is protracted healing course and inferior scar quality--either hypo- or hypertrophic. Local and systemic application of these growth factors seems to add important instruments for therapeutic use in the treatment of chronic wounds. Knowledge from experimental research is encouraging, although the exact mechanisms of synergistic action are not completely understood. However, the results from clinical use in controlled studies do not meet these expectations by far. The main reasons for this dilemma are thought to be little understanding in the complex interactions of these substances. In fact, different wound entities seem to reveal different cytokine profiles during the course of repair. Further intensive research therefore is required for the rational use of growth factors in the clinical setting.
Chirurgische Universitätsklinik, Würzburg. sebastian.debus@mail.uni-wuerzburg.de
E S
ES
Debus
K
K
Schmidt
U E
UE
Ziegler
A
A
Thiede
D000818:Animals; D003115:Colony-Stimulating Factors / Q000494:pharmacology / Q000627:therapeutic use; D016228:Endothelial Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D004815:Epidermal Growth Factor / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D051526:Fibroblast Growth Factor 10; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D006133:Growth Substances / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008222:Lymphokines / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology / Q000627:therapeutic use; D020033:Protein Isoforms; D051381:Rats; D012106:Research; D013002:Somatomedins / Q000494:pharmacology / Q000627:therapeutic use; D013552:Swine; D015291:Transforming Growth Factors / Q000494:pharmacology / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000276:immunology
D003115:Colony-Stimulating Factors; D016228:Endothelial Growth Factors; C496453:FGF7 protein, human; C496455:Fgf7 protein, rat; D051526:Fibroblast Growth Factor 10; D006133:Growth Substances; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D020033:Protein Isoforms; D013002:Somatomedins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D015291:Transforming Growth Factors