[D-lactic acidosis in short bowel syndrome].
A boy of 20 months and a girl of 27 months who had previously undergone massive bowel resection due to congenital intestinal obstruction are described. During gradual reduction of total parenteral nutrition and initiation of oral feeding, both developed severe, acute metabolic acidosis, accompanied by encephalopathy and ataxia. After the laboratory identification of massive amounts of the d-isomer of lactic acid in urine and blood, both were successfully treated with i.v. bicarbonate, and metronidazole to suppress the overgrowth of colonic lactobacilli responsible for the metabolic crisis.
Sela
B A
BA
Institute of Chemical Pathology and Pediatric Intensive Care, Sheba Medical Center, Tel Hashomer.
Zlotnik
J
J
Masos
T
T
Danieli
J
J
Mazia-Beni
S
S
Jonas
A
A
D000140:Acidosis, Lactic / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D001639:Bicarbonates / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007536:Isomerism; D007773:Lactates / Q000097:blood; D008297:Male; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications; D012778:Short Bowel Syndrome / Q000601:surgery*
D001639:Bicarbonates; D007773:Lactates