Sophisticated medical devices as local drug-delivery systems.
The sustained release of antimicrobial substances from catheters, endoprostheses, wound-dressings and arterial grafts may be prudent for the prevention of device-associated infections. The release of heparin, synthetic prostacycline, hirudin and anti-inflammatory dexamethasone and related compounds from stent coatings may further reduce the risk of thrombosis, intimal hyperplasia and the requirement for long-term anticoagulation treatments. The delivery of cytokines and growth factors from wound dressings and bone grafts may accelerate wound healing and implant integration.
Schierholz
J M
JM
Institute for Scientific Evaluation of Naturopathy, University of Cologne, Germany.
Beuth
J
J
D000890:Anti-Infective Agents / Q000008:administration & dosage; D000925:Anticoagulants / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000009:adverse effects; D004864:Equipment and Supplies; D006801:Humans; D011108:Polymers
D000890:Anti-Infective Agents; D000925:Anticoagulants; D011108:Polymers