Antimicrobial constituents of the leaves of Acalypha wilkesiana and Aacalypha hispida.
An activity directed fractionation of a 50% aqueous ethanol extract of A. wilkesiana and A. hispida leaves resulted in the isolation of gallic acid, corilagin and geraniin as the compounds responsible for the observed antimicrobial activity. Quercetin 3-O-rutinoside and kaempferol 3-O-rutinoside were also isolated from the inactive fraction of A. hispida. The structures were established by permethylation, 2D - NMR ((1)H and (13)C) and MS data.
Adesina
S K
SK
Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
Idowu
O
O
Ogundaini
A O
AO
Oladimeji
H
H
Olugbade
T A
TA
Onawunmi
G O
GO
Pais
M
M
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry; D006801:Humans; D047348:Hydrolyzable Tannins; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013634:Tannins
D000900:Anti-Bacterial Agents; D005960:Glucosides; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D013634:Tannins; C024603:Geraniin; C049096:corilagin