[The effect of alpha-1 adrenergic blockade on the clinical course, immune status and blood plasma lipid spectrum in patients with ischemic heart disease].
Results are submitted of investigations designed to study effects of prazosine on the clinical course, immune and lipid spectrum of blood plasma in IHD patients with functional class I-II middle-aged and elderly-onset exertional angina. Efficiency of prazosine monotherapy was recordable in all FC I-II effort angina patients 30 to 50 years old, which fact was manifested by a decline in the number of angina attacks over the 24-hour period, number and duration of both pain and symptom-free myocardial ischemia, improvement in physical load tolerance. Also recordable in all patients was a positive effect of the drug on blood plasma lipid spectrum and certain immunological indices.
Lizogub
V G
VG
Chumak
A A
AA
Savchenko
A V
AV
Pliskevich
D A
DA
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D005082:Physical Exertion / Q000187:drug effects; D011224:Prazosin / Q000627:therapeutic use*
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D008055:Lipids; D011224:Prazosin