LAP proteins: what's up with epithelia?
How cells maintain their overall shape and size, and the related question of how proteins and other molecules reach and stay at their specific subcellular locations, are among the most difficult and exciting problems in cell biology. Three recent studies have made a significant contribution to this area by identifying new proteins, called LAP proteins, that have critical functions in maintaining the shape and apical-basal polarity of epithelial cells.
Bryant
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PJ
Huwe
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D048868:Adaptor Proteins, Signal Transducing; D020816:Amino Acid Motifs; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D016764:Cell Polarity; D048429:Cell Size; D029721:Drosophila Proteins; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D015801:Helminth Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007930:Leucine / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D029721:Drosophila Proteins; C413364:ERBIN protein, human; D015801:Helminth Proteins; C413362:LET-413 protein, C elegans; D008565:Membrane Proteins; C404683:Scrib protein, Drosophila; D007930:Leucine