Exceptionally long absence status: multifactorial etiology, drug interactions and complications.
To our knowledge, petit mal status lasting longer than 2-3 days has been documented only once [1]. We report a 66 year-old man with well-documented, idiopathic generalized epilepsy who developed petit mal status lasting 6 weeks. Valproate levels remained low because of interactions with phenytoin. When phenytoin was discontinued, valproate levels increased, and he progressively improved. Chronic ischemic changes in the white matter may have been an additional factor in the causation and, most likely, in the duration of his status. Exceptionally long status and stupor increase the risk of medical complications. Valproate remains the medication of choice for the treatment of petit mal status. Despite the extraordinary course in this patient, complete recovery took place, confirming the benign nature of even such a prolonged episode.
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
M D
MD
D'Agostino
F
F
Andermann
F
F
Dubeau
M
M
Fedi
A
A
Bastos
D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002545:Brain Ischemia / Q000150:complications* / Q000175:diagnosis; D015140:Dementia, Vascular / Q000150:complications / Q000175:diagnosis; D004347:Drug Interactions; D004829:Epilepsy, Generalized / Q000188:drug therapy*; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D013226:Status Epilepticus / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D014635:Valproic Acid; D010672:Phenytoin