Alterations in the reproduction of mice induced by rapanone.
Oral administration of rapanone to a group of female mice at doses of 60 and 120 mg/kg, reduced the percentage of pregnancies compared to control group, suggesting an anovulatory effect. Postcoital administration induced uterine alteration in both the first and second gestation periods. These results seem to indicate inhibition of trophoblast implantation in the first period, and an abortive effect and/or reabsorption in the second. Daily administration of rapanone to a group of male mice resulted in fertility alteration, which is attributed to an antispermatogenic effect. Rapanone did not show acute toxic effects at the doses tested in this research.
Calle
J
J
Departamento de Farmacia, Universidad Nacional de Colombia, Apartado aereo 14490, Santafé de, Bogotá, Colombia.
Olarte
J
J
Pinzon
R
R
Ospina
L F
LF
Mendoza
M C
MC
Orozco
M J
MJ
D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology*; D003270:Contraceptive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D008297:Male; D051379:Mice; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy
D016227:Benzoquinones; D003270:Contraceptive Agents; C054611:rapanone