Chemopreventive activity of quercetin during carcinogenesis in cervix uteri in mice.
The chemopreventive action of quercetin was examined during 20-methyl cholanthrene induced cervical neoplasia in virgin Swiss albino mice. The effects were evaluated on the basis of histopathological observation of the cervical epithelium, micronucleus frequency in vaginal exfoliated cells and some biochemical parameters in the host liver. Quercetin was found to arrest or reverse the progression of cervical neoplasia. The micronucleus frequency was reduced following its administration. The potential anti-carcinogenic effect of quercetin noted in this study is attributed to its antioxidant property which was reflected in the lipid peroxides and their role in the host detoxification system, as expressed in liver glutathione level, glutathione-S-transferase, glutathione peroxidase, catalase and superoxide dismutase activity. As an integral part of the diet quercetin may offer protection to the epithelium from the damaging effects of carcinogenic chemicals.
Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Calcutta, India.
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D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001551:Benz(a)Anthracenes; D002273:Carcinogens; D004195:Disease Models, Animal; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D011794:Quercetin / Q000494:pharmacology / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D001551:Benz(a)Anthracenes; D002273:Carcinogens; C053714:cholanthrene; D011794:Quercetin