Hormonal treatment of an endometrial stromal nodule followed by local excision.
BACKGROUND
Endometrial stromal nodule is a rare subtype of endometrial stromal tumor. Although such nodules are benign, hysterectomy has been considered the treatment of choice, because evaluation of the margin is required for diagnosis. The similarity between low-grade stromal sarcoma and stromal nodule suggests that stromal nodules might respond to hormonal management.


METHODS
Twenty-one-year-old nulligravida, diagnosed with endometrial stromal nodule, which decreased in size with leuprolide acetate treatment, underwent local excision of the tumor with preservation of reproductive function.


CONCLUSIONS
Hormonal therapy was successful in decreasing the size of this stromal nodule which allowed for conservative management.
Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, USA. jschilde@iunet.iupui.edu
J M
JM
Schilder
W W
WW
Hurd
L M
LM
Roth
G P
GP
Sutton
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D016729:Leuprolide / Q000008:administration & dosage*; D018203:Sarcoma, Endometrial Stromal / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide