[Intracranial tuberculomas developing during treatment of pulmonary tuberculosis: case report].
The classical presentation of neurotuberculosis is meningitis. Intracranial tuberculomas are a rare manifestation of neurotuberculosis and are due to hematogenous dissemination of distant focuses of Mycobacterium tuberculosis infection. Around 1% of patients with central nervous system tuberculosis develop intracranial tuberculomas some weeks or months after the beginning of the specific treatment with tuberculostatic chemotherapy. The involution of the lesions is slow and does not mean drug resistance nor lack of adequate treatment. We describe the case, diagnosed and treated at the 25th Infirmary of Santa Casa da Misericórdia do Rio de Janeiro, of an immunocompetent male patient who developed meningitis and multiple intracranial tuberculomas during the specific treatment of miliary tuberculosis. The literature is revised and the diagnosis, treatment and possible immunological mechanisms are discussed.
Faculdade de Medicina, Universidade Gama Filho, Brazil. jotapim@centroin.com.br
M L
ML
Pimentel
S M
SM
Alves
S A
SA
Novis
R Z
RZ
Brandão
E
E
Belo Neto
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011718:Pyrazinamide / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed / Q000379:methods; D016862:Tuberculoma, Intracranial / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D014390:Tuberculosis, Meningeal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D014391:Tuberculosis, Miliary / Q000150:complications / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy*
D000995:Antitubercular Agents; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin