Light chain deposition disease neuropathy resembling amyloid neuropathy in a multiple myeloma patient.
A 65-year-old man with IgG lambda multiple myeloma developed severe polyneuropathy with prominent thermal-pain sensory impairment and autonomic failure. Although the clinical presentation suggested amyloid neuropathy, nerve biopsy showed the immunohistochemical and ultrastructural features typical of light chain deposition disease (LCDD). A precise morphologic and clinical description of LCDD neuropathy is given for the first time in the present report.
Department of Neurology, L. Sacco Hospital, Milan, Italy.
M P
MP
Grassi
F
F
Clerici
C
C
Perin
M
M
Borella
A
A
Gendarini
A
A
Quattrini
R
R
Nemni
A
A
Mangoni
D000368:Aged; D000686:Amyloidosis / Q000276:immunology / Q000473:pathology*; D001706:Biopsy; D005455:Fluorescent Antibody Technique; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D008297:Male; D008854:Microscopy, Electron; D009101:Multiple Myeloma / Q000276:immunology / Q000473:pathology*; D011115:Polyneuropathies / Q000276:immunology / Q000473:pathology*; D013497:Sural Nerve / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure
D007147:Immunoglobulin Light Chains