Cell biology. Travel bulletin--traffic jams cause tumors.
All animal cells have a polarity, that is, different proteins are clustered in distinct domains of the plasma membrane and these regions carry out different jobs. As Peifer discusses in a lively Perspective, new work (Bilder et al.) identifies some of the molecular characters that direct proteins to their different cellular destinations.
Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. peifer@unc.edu
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D000818:Animals; D001692:Biological Transport; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D002471:Cell Transformation, Neoplastic; D003593:Cytoplasm / Q000378:metabolism; D004330:Drosophila / Q000166:cytology / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007365:Intercellular Junctions / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D009154:Mutation; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D010641:Phenotype; D017434:Protein Structure, Tertiary; D025521:Tumor Suppressor Proteins
D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; C404683:Scrib protein, Drosophila; D025521:Tumor Suppressor Proteins; C081435:l(2)gl protein, Drosophila; C070350:dlg1 protein, Drosophila