Computation of writhe in modeling of supercoiled DNA.
We describe four previously unpublished methods allowing the computation of the writhe for a supercoiled DNA molecule modeled by a polymer chain consisting of straight segments. These methods are compared with each other in terms of computational efficiency and the scope of their applicability is discussed.
Division Biophysics of Macromolecules, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
K
K
Klenin
J
J
Langowski
D001696:Biomechanical Phenomena; D003198:Computer Simulation; D004278:DNA, Superhelical / Q000737:chemistry*; D008433:Mathematics; D008956:Models, Chemical; D008958:Models, Molecular; D014102:Torsion Abnormality
D004278:DNA, Superhelical