Propionibacterium acnes as a cause of visually significant corneal ulcers.
OBJECTIVE
To report Propionibacterium acnes as a cause of vision-threatening infectious keratitis and to discuss culture isolation and antibiotic treatment.


METHODS
Retrospective case series presentation collected from three academic medical centers.


RESULTS
Six cases of P. acnes infectious keratitis are presented, all of which were associated with a compromised corneal barrier or environment. All cases were culture-positive on thioglycolate broth; none became positive before 7 days of growth. No other organisms were isolated from any culture, and the growth of P. acnes occurred in some cases despite negative gram stains.


CONCLUSIONS
P. acnes can produce vision-debilitating keratitis when the cornea is compromised. Growth in culture should be monitored for at least 10 days to ensure isolation of this fastidious organism. P. acnes may respond to several different antibiotics that have gram-positive coverage, but it should be treated with vancomycin to enhance clearance of the organism.
Jules Stein Eye Institute, UCLA, Los Angeles, California 90095, USA.
J P
JP
Underdahl
G J
GJ
Florakis
R E
RE
Braunstein
D A
DA
Johnson
P
P
Cheung
J
J
Briggs
D M
DM
Meisler
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents; D003315:Cornea / Q000382:microbiology* / Q000473:pathology; D003320:Corneal Ulcer / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011425:Propionibacterium acnes / Q000302:isolation & purification*; D012189:Retrospective Studies; D014792:Visual Acuity
D000900:Anti-Bacterial Agents