Immune recognition of glomerular antigens.
Autoimmunity is thought to cause most varieties of glomerulonephritis including membranous nephropathy, minimal-change nephropathy, Goodpasture's disease and possibly IgA nephropathy. Much effort has been and is directed at understanding the mechanisms of immune system driven inflammation and of the consequent renal injury and repair or scarring. The purpose of this article is to focus attention on the way the immune system recognizes kidney autoantigens, a process that must be a pivotal in the initiation of autoimmune kidney disease.
Department of Clinical and Surgical Sciences (Internal Medicine), University of Edinburgh, UK.richard.phelps@ed.ac.uk
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Phelps
D000595:Amino Acid Sequence; D000818:Animals; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology*; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003094:Collagen / Q000737:chemistry / Q000276:immunology; D024141:Collagen Type IV; D006684:HLA-DR Antigens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D059810:HLA-DR Serological Subtypes; D006801:Humans; D007109:Immunity; D007678:Kidney Glomerulus / Q000276:immunology*; D008958:Models, Molecular; D008969:Molecular Sequence Data
D001324:Autoantigens; D024141:Collagen Type IV; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen; C057112:type IV collagen alpha3 chain; D003094:Collagen