[Synthesis and antidepressive activity study of aryl and heteroaryl carboxamides of benzylpiperazine].
The synthesis of 44 original amide derivatives of benzylpiperazine and some analogues of befuraline and piberaline is reported. All compounds have been tested as antidepressive agents. According to the tests, amides 1, 24 and mainly 31 (dihydrobefuraline) seem to provide elevated antidepressive activity.
Chimie Pharmaceutique, Faculté de Pharmacie, 35 Chemin des Maraîchers, F-31400 Toulouse.
S
S
Younes-El-Hage
Y
Y
Labssita
G
G
Baziard-Mouysset
M
M
Payard
D H
DH
Caignard
C
C
Rubat
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007035:Hypothermia / Q000503:physiopathology; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology; D013315:Stress, Psychological / Q000188:drug therapy; D015016:Yohimbine / Q000494:pharmacology
D000928:Antidepressive Agents; D010879:Piperazines; D015016:Yohimbine; D012110:Reserpine