A pre-coital pill? A preliminary in vitro study.
The use of the progestogen-only pill as a 'pre-coital contraceptive' was tested by in vitro studies of sperm-mucus interaction. The results suggest that a single tablet of levonorgestrel 30 microg, or norethisterone 350 microg, was effective in preventing sperm migration in the cervical mucus about 12 hours later. This suggests that the progestogen-only pill may be effective as a 'morning before pill'.
Monash Medical School, Box Hill Hospital, Victoria, Australia.
G T
GT
Kovacs
J
J
Hendricks
D
D
Summerbell
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HW
Baker
D002582:Cervix Mucus / Q000187:drug effects*; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D066298:In Vitro Techniques; D016912:Levonorgestrel / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009640:Norethindrone / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D013081:Sperm Motility / Q000187:drug effects*
D003280:Contraceptives, Oral, Synthetic; D016912:Levonorgestrel; D009640:Norethindrone