[Monitoring high dose methotrexate therapy (HD MTX) in children with osteosarcoma and computer simulation using a pharmacokinetic model].
The pharmacokinetics of methotrexate (MTX) was studied in 15 children with osteosarcoma, treated (54 courses) with high-dose methotrexate (8, 10 i 12 g/m2; 4 h i.v. infusion). Pharmacokinetic analysis was performed by standard non-compartmental methods and using two-compartment nonlinear model with coexistence of additional, parallel linear route of elimination from central compartment. The model was used for computer simulation and prognosis of the serum-level curve course depending on the simulated dosage, enhanced diuresis and simulated kidney or liver insufficiency during the dose individualization. The usage of the pharmacokinetic model for computer simulations may improve understanding of the MTX kinetics and can optimise dosage regimens for the next cycles of chemotherapy.
Instytut Matki i Dziecka w Warszawie.
W
W
Taljański
J
J
Zimak
A
A
Piekarczyk
D000293:Adolescent; D019540:Area Under Curve; D001825:Body Fluid Compartments / Q000502:physiology; D001859:Bone Neoplasms / Q000188:drug therapy*; D002648:Child; D003198:Computer Simulation; D016903:Drug Monitoring; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008954:Models, Biological; D012516:Osteosarcoma / Q000188:drug therapy*
D008727:Methotrexate