Effects of triterpenes from the stem bark of Dysoxylum cauliflorum on a non-small-cell bronchopulmonary carcinoma cell line (NSCLC-N6).
Six triterpenoids and one sesquiterpene were isolated from the ethanolic extract of the stem bark of Dysoxylum cauliflorum. Their structures were determined from 1D and 2D NMR and mass spectral data. Only compound 1 was cytostatic. Kinetic studies with ethyl eichlerianoate 1 demonstrated that this growth arrest was irreversible and cytofluorimetric analysis with compound 1 showed a complete block of NSCLC-N6 cells in the G1 phase. These events were related to a terminal maturation induction.
GDR-CNRS Substances Naturelles d'Interet Therapeutique, Faculte de Pharmacie, Nantes, France. benosman@altern.org
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Benosman
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Richomme
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Roussakis
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Sévenet
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Hadi
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Bruneton
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung; D002452:Cell Count / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D016193:G1 Phase / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms; D009682:Magnetic Resonance Spectroscopy; D018547:Plant Stems / Q000737:chemistry; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D014315:Triterpenes