Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics.
Peroxynitrite is an oxidant generated under inflammatory conditions, acting in defense against invading microorganisms. There is a need for protection of the organism from damage inflicted by peroxynitrite. Selenium-containing compounds, notably ebselen, have a high second-order reaction rate constant (approx. 2 x 10(6) M(-1) s(-1)), which makes them candidates for efficient protection. This applies also for selenium in proteins, occurring as selenocysteine or selenomethionine residues. Glutathione peroxidases, thioredoxin reductase, and selenoprotein P have been shown to play a potential role in protection against peroxynitrite. Tellurium-containing compounds also react with peroxynitrite.
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Institut für Physiologische Chemie I, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany. helmut.sies@uni-dusseldorf.de
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D000975:Antioxidants / Q000378:metabolism; D001393:Azoles / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D054833:Isoindoles; D009566:Nitrates / Q000378:metabolism*; D016566:Organoselenium Compounds / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism*; D018384:Oxidative Stress; D011506:Proteins / Q000378:metabolism*; D017279:Selenocysteine / Q000378:metabolism; D012645:Selenomethionine / Q000378:metabolism; D051149:Selenoprotein P; D051140:Selenoproteins; D013691:Tellurium / Q000378:metabolism; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism
D000975:Antioxidants; D001393:Azoles; D005609:Free Radicals; D054833:Isoindoles; D009566:Nitrates; D016566:Organoselenium Compounds; D016877:Oxidants; D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D017279:Selenocysteine; C039642:peroxynitric acid; C042986:ebselen; D012645:Selenomethionine; D005979:Glutathione Peroxidase; D013880:Thioredoxin-Disulfide Reductase; D013691:Tellurium