Hybrid fibrillation potentials and positive sharp waves.
Fibrillation potential configurations are characterized as initially positive triphasic waveforms, whereas positive sharp waves appear biphasic with an initial positive deflection. Careful observation of single muscle fiber discharges in denervated muscle, however, can reveal many different-appearing and stable firing waveforms that resemble a bifid positive sharp wave or some form of combined fibrillation potential and positive sharp wave. In this investigation, a number of atypical-appearing single muscle fiber discharges are hypothesized to arise from particular interactions between the muscle fiber and recording electrode. Single muscle fiber potentials are modeled as originating from a single denervated muscle fiber's former endplate and midfiber region as well as from the fiber's tendinous termination for both a compressed and sealed end effect. The modeled waveforms' appearance corresponds well to those obtained clinically and the necessary interpotential summated templates' temporal domains are feasible for action potential termination at the electrode with subsequent reinitiation beyond the proposed peri-electrode compressed region. It is hypothesized that the majority of hybrid waveforms are the result of a single muscle fiber action potential terminating at a recording electrode while also initiating a "skipped" activation of the muscle fiber past the electrode resulting in the summation of two distinct time-locked waveforms.
Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, 78229-3900, USA. dumitru@uthscsa.edu
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D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003198:Computer Simulation; D003964:Diaphragm / Q000166:cytology / Q000294:innervation / Q000502:physiology; D004566:Electrodes; D006801:Humans; D008954:Models, Biological; D009119:Muscle Contraction / Q000502:physiology*; D009121:Muscle Denervation; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D051381:Rats; D011930:Reaction Time / Q000502:physiology