PDE4D-deficient mice knock the breath out of asthma.
Giembycz
M
M
m.giembycz@ic.ac.uk
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000502:physiology*; D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000201:enzymology; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D043585:Receptor, Muscarinic M2; D011976:Receptors, Muscarinic / Q000502:physiology
D010726:Phosphodiesterase Inhibitors; D043585:Receptor, Muscarinic M2; D011976:Receptors, Muscarinic; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; C517376:PDE4D protein, human