[Deletion of MTS1/p16 gene in endometrial carcinoma].
OBJECTIVE
To investigate the possible relationship between deletion of MTS1/p16 gene and progression of endometrial carcinoma.


METHODS
Thirty two primary endometrial carcinoma, 7 tumor-adjacent endometrial tissue and 10 normal endometrial tissue specimens were examined for homozygous deletion of MTS1/p16 gene by polymerase chain reaction-based analysis.


RESULTS
Of 32 endometrial cancer specimens, 6(18.8%) showed homozygous deletion of MTS1/p16 gene. No deletion was detected in the tumor-adjacent and normal endometrial tussues. Nor was it detected in well differentiated endometrial carcinoma.


CONCLUSIONS
Deletion of MTS1/p16 gene might contribute to the progression of endometrial carcinoma and could be served as indicator for predicting prognosis.
Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
C
C
Zhou
J
J
Sun
S
S
Lu
D000230:Adenocarcinoma / Q000235:genetics*; D018196:Carcinoma, Adenosquamous / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D019942:Genes, p16; D006801:Humans; D016133:Polymerase Chain Reaction