[Immunological status and its changes in children during surgery on anterior eye segment].
Nonspecific and specific immunity values were studied in 70 children before and in various periods after 74 operations on the anterior segment of the eyeball. In children with persistent autosensitization to ocular tissue autoantigens (alpha-crystalline and S-antigen) postoperative uveitis presented as an immunocomplex disease with signs of exhaustion of the functional potential of the phagocytosis and complement systems. In children without autosensitization uveitis was associated with immunity activation. Phagocytosis system and cooperation of lymphocyte subpopulations, including normal killers (CD16+), play an important role in prevention of sensitization to ocular tissue autoantigens. Therefore, complex immunological examinations of children before surgery and regular check-ups after it will help differentiate immunodeficiency from compensatory immunosuppression preventing autoimmune disease, which is important in prescription of immunostimulating therapy.
Aznabaev
M T
MT
Speranskiĭ
V V
VV
Aznabaev
R A
RA
Golovin
V P
VP
Iakovleva
V G
VG
Aznabaeva
L F
LF
D000293:Adolescent; D000869:Anterior Eye Segment / Q000276:immunology / Q000601:surgery*; D019393:Arrestin / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D003459:Crystallins / Q000276:immunology; D005128:Eye Diseases / Q000276:immunology / Q000601:surgery*; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D013508:Ophthalmologic Surgical Procedures; D010587:Phagocytosis / Q000276:immunology; D017452:Receptors, IgG / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D019393:Arrestin; D001324:Autoantigens; D003459:Crystallins; D007166:Immunosuppressive Agents; D017452:Receptors, IgG