Antifilarial activity of some 2H-1-benzopyran-2-ones (coumarins).
Six synthetic 2H-1-benzopyran-2-one (cournarin) derivatives (CDRI compounds # 1, 2, 3, 4, 5 and 6) were evaluated for filaricidal activity against Litomosoides carinii and Acanthocheilonema viteae infections in cotton rats (Sigmodon hispidus) and Mastomys coucha respectively. Significant effects on macrofilariae (>80% death/sterilisation) were detected with compounds #2, 3 and 6 against L. carinii and/or A. viteae. Thus detection of filaricidal activity in benzopyrones, which are so far known for anti-inflammatory activity, provides a new lead for development of better filaricidal agents for combating filariasis.
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
R P
RP
Tripathi
R
R
Tripathi
A P
AP
Bhaduri
S N
SN
Singh
R K
RK
Chatterjee
P K
PK
Murthy
D000284:Administration, Oral; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology*; D004153:Dipetalonema / Q000187:drug effects*; D004154:Dipetalonema Infections / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005368:Filariasis / Q000097:blood / Q000188:drug therapy*; D005370:Filarioidea / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D008842:Microfilariae; D013987:Ticks
D000925:Anticoagulants; D003374:Coumarins