Serotype distribution and antimicrobial resistance patterns of invasive isolates of Streptococcus pneumoniae: Alaska, 1991-1998.
From January 1991 through December 1998, a total of 1046 pneumococcal isolates were received from 23 laboratories participating in the statewide surveillance system. Of these, 1037 were recovered from normally sterile sites (blood and cerebrospinal and pleural fluid) and were available for serotyping and susceptibility testing. Ninety-two percent of these isolates were serotypes represented in the 23-valent pneumococcal polysaccharide vaccine. Serotypes in the 7-valent pneumococcal conjugate vaccine (4, 6B, 9V, 14, 18C, 19F, and 23F) were recovered from 72% of Alaska Natives and 84% of non-Native children <5 years old with invasive disease. Statewide, 7.3% and 3.2% of isolates had intermediate and high levels of resistance to penicillin, respectively; 9.2% were resistant to erythromycin (minimal inhibitory concentration, >/=1 microg/mL) and 19% to trimethoprim/sulfamethoxazole (minimal inhibitory concentration, >/=4/76 microg/mL). Twelve percent of invasive isolates were resistant to >/=2 classes of antibiotics; of these, serotype 6B accounted for 33%, and 63% were recovered from children <5 years old.
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Anchorage, AK 99508,USA. kmr2@cdc.gov.
K M
KM
Rudolph
A J
AJ
Parkinson
A L
AL
Reasonover
L R
LR
Bulkow
D J
DJ
Parks
J C
JC
Butler
D000413:Alaska; D001428:Bacterial Vaccines / Q000276:immunology / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D007198:Indians, North American; D007223:Infant; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000097:blood / Q000134:cerebrospinal fluid; D011135:Polysaccharides, Bacterial / Q000276:immunology / Q000627:therapeutic use; D011159:Population Surveillance; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000276:immunology / Q000472:pathogenicity*; D013997:Time Factors; D014296:Trimethoprim Resistance; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
D001428:Bacterial Vaccines; D011135:Polysaccharides, Bacterial; D004917:Erythromycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination