[Microscopic polyangiitis accompanying interstitial pneumonia with aluminum lung].
A 67-year-old man who had worked as an aluminum grinder had been given a diagnosis of pneumoconiosis. Ten years later, he was admitted with fever, dyspnea on exertion, and numbness. Chest roentgenograms showed linear-reticular shadows in both lower lung fields. ELISA-based tests were positive for perinuclear anti-neutrophil cytoplasmic antibody (P-ANCA). Renal biopsy specimens disclosed crescentic glomerulonephritis and angiitis of small arteries. Our diagnosis was microscopic polyangiitis accompanying interstitial pneumonia with aluminum lung. The results of high-energy dispersion X-ray microanalysis indicated that the patient's lungs contained aluminum. His general condition improved with the administration of corticosteroid and immunosuppressive agents, and his chief symptoms disappeared.
Seike
M
M
Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Enomoto
T
T
Henmi
S
S
Uematsu
K
K
Azuma
A
A
Yoshimura
A
A
Takasaki
Y
Y
Mochimaru
H
H
Fukuda
Y
Y
Kudoh
S
S
D000368:Aged; D000535:Aluminum; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008669:Metallurgy; D011009:Pneumoconiosis / Q000150:complications* / Q000188:drug therapy; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone; D000535:Aluminum