Pyrrolo[2,1-d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity.
The title compounds, that hold the deaza skeleton of temozolomide, exhibited potent in vitro antiproliferative activity. An evaluation of such a biological activity indicates that the mode of action of these compounds differs from that of temozolomide and is also mechanistically unrelated to that of any known antitumor drug.
Dipartimento Farmacochimico Tossicologico e Biologico, Università di Palermo, Italy.
P
P
Diana
P
P
Barraja
A
A
Lauria
A M
AM
Almerico
G
G
Dattolo
G
G
Cirrincione
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000494:pharmacology; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000494:pharmacology; D000077204:Temozolomide
D018906:Antineoplastic Agents, Alkylating; D006574:Heterocyclic Compounds, 2-Ring; D003606:Dacarbazine; D000077204:Temozolomide