Subchronic in vivo effects of a high static magnetic field (9.4 T) in rats.
The potential adverse biologic effects of sub chronic (cumulatively 10 weeks) exposure to a high magnetic field (9.4 T) were evaluated in young adult male and female Fischer rats as well as in their progeny. Biologic end points in adult rats included changes in daily clinical observations; spatial memory tests; weekly heart rates, body weights, food and water consumption, and the feed efficiency ratio; terminal hematologic, blood biochemical and urinary parameter changes; gross pathologic findings; and major organ weights. In offspring, biologic end points included the gestation period, number of live births, number of pups, ratio of male to female pups/litter; postnatal time period of eye opening; birth and weekly body weights, behavioral changes, central nervous system responses, as well as hematologic, blood biochemistry, and urinary parameter changes; and gross pathologic findings. Findings from this study showed that there were no adverse biologic effects in male and female adult rats or their progeny that could be attributed to 10-week exposure to a 9.4-T static magnetic field.
High
W B
WB
Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis 55455, USA. high@cmrr.umn.edu
Sikora
J
J
Ugurbil
K
K
Garwood
M
M
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001066:Appetite / Q000528:radiation effects; D001522:Behavior, Animal / Q000528:radiation effects*; D001835:Body Weight / Q000528:radiation effects; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005247:Feeding Behavior / Q000528:radiation effects*; D005260:Female; D006066:Gonads / Q000473:pathology; D006339:Heart Rate / Q000528:radiation effects; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000528:radiation effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000528:radiation effects*; D051381:Rats; D012016:Reference Values; D018570:Risk Assessment; D012737:Sex Factors; D015996:Survival Rate