A behavioral analysis of the ingestion of glucose, maltose and maltooligosaccharide by rats.
Glucose, maltose, and Polycose are stimuli that differ in their effectiveness in stimulating ingestion in the rat. To understand better how variation in glucose chain length affects the ingestion of these compounds, we compared the effect of six concentrations of glucose, maltose, and maltooligosaccharide (MOS) on the microstructure of the licking behavior of the rat. At the three lowest concentrations the order of effectiveness in stimulating ingestion was MOS > maltose > glucose. At the three highest concentrations, there were no differences among the three compounds in volume ingested. As measured by initial rate of licking, the orosensory stimulating effectiveness of the three compounds were ordered as MOS > maltose > glucose. The magnitude of the negative feedback signals were very similar for MOS and maltose and greater than glucose at all but the highest two concentrations of glucose, suggesting that glucose chain length, not caloric density, is responsible for the differences in the magnitude of negative feedback. With the three lowest concentrations, the ordering of the compounds in their ability to stimulate intake depended on orosensory stimulating ability.
Department of Psychiatry, Joan and Sanford I. Weill Medical College of Cornell, University, and the E. W. Bourne Behavioral Research Laboratory, New York Hospital, Cornell Medical Center, 21 Bloomingdale Rd, White Plains, NY 10605, USA.
J D
JD
Davis
P A
PA
Breslin
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D008320:Maltose / Q000378:metabolism* / Q000494:pharmacology; D009844:Oligosaccharides / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects
D009844:Oligosaccharides; C021705:maltooligosaccharides; D008320:Maltose; D005947:Glucose