Preparation of L-alpha-phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2).
Practical, asymmetric total syntheses of the title phospholipids from a readily available myo-inositol derivative as well as short chain and cross-linkable aminoether analogues are described.
Falck
J R
JR
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75390, USA. jfalck@biochem.swmed.edu
Krishna
U M
UM
Capdevila
J H
JH
D010716:Phosphatidylinositols / Q000138:chemical synthesis* / Q000737:chemistry; D010766:Phosphorylation
D010716:Phosphatidylinositols