[Changes of airway responsiveness, and relative factors in asthmatics with remission at puberty].
OBJECTIVE
To study the airway responsiveness and relative factors in asthmatics with natural remission at puberty.


METHODS
The airway responsiveness was evaluated by challenge of methacholine (PC20), blood sIL-2R, eosinophil count, basophil count and basophil releasability were detected in 18 asthmatics with remission at puberty (group I), in 20 asthmatics without remission at puberty (group II), and in 30 healthy controls (group III).


RESULTS
The mean value of PC20 in the group I was significantly lower than that of the group III (P < 0.01), but still higher than that of the group II (P < 0.01). The blood sIL-2R and eosinophil values were droped almost to those of the group III, significantly lower than those of the group II. The basophil value and positive rate of human basophil degranulation test stimulated by mannitol with hyperosmolarity were still abnormal, significantly higher than those of the group III, and the basophil level was significantly related to the airway responsiveness.


CONCLUSIONS
The asthmatics with remission at puberty have a certain degree of airway hyperresponsivenes that is related to the abnormal of basophil.
Research Lab of COPD Renji Hospital, Shanghai No. 2 Medical University.
Y P
YP
Xu
S H
SH
Yao
L J
LJ
Zhu
D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011627:Puberty; D012075:Remission, Spontaneous; D012130:Respiratory Hypersensitivity / Q000503:physiopathology*