Genetic alterations in human prostate cancer: a review of current literature.
We review the literature dealing with genetic alterations in human prostate cancer. We also discuss genetic predisposition and the roles of various proto-oncogenes and tumor-suppressor genes in prostate cancer initiation, progression, and metastasis. The role of telomere dynamics in prostate cancer metastasis and the induction of apoptosis is also briefly discussed.
Department of Cancer Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
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D000230:Adenocarcinoma / Q000235:genetics*; D015703:Antigens, CD; D017209:Apoptosis; D002869:Chromosome Aberrations; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D017491:Genes, APC; D016147:Genes, Tumor Suppressor; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D051861:Kangai-1 Protein; D019656:Loss of Heterozygosity; D008297:Male; D008562:Membrane Glycoproteins; D009154:Mutation; D009857:Oncogenes; D011471:Prostatic Neoplasms / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D011519:Proto-Oncogenes; D019098:Telomerase / Q000235:genetics / Q000502:physiology; D016615:Telomere / Q000648:ultrastructure
D015703:Antigens, CD; C497688:CD82 protein, human; D004273:DNA, Neoplasm; D006133:Growth Substances; D051861:Kangai-1 Protein; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D019098:Telomerase