[Study of the relationship between the expression of Ki-67 antigen and the pathobiological behaviours of stomach cancer].
OBJECTIVE
To evaluate the relationship between the expression of Ki-67 antigen and the pathobiological behaviours of stomach cancers especially their distant metastases.


METHODS
56 stomach cancer specimens routinely fixed in formalin and embeded in paraffin (FFEP) were studied by immunohistochemical method.


RESULTS
Expression of Ki-67 antigen was significantly related to the distant metastases to liver, ovary and adrenal gland (P < 0.005); but not related to the histological type, growth pattern, depth of invasion, histological differentiation and the metastases to local lymph nodes (P > 0.05). Furthermore, the Ki-67 expression was significantly related to the DNA anueploid pattern and the expression of p53 protein, both of which are closely related to poor prognosis.


CONCLUSIONS
Overexpression of Ki-67 can be used as an objective marker of the proliferative activity for predicting prognosis of stomach cancer and to foretell the high-risk of metastasis of distant organs.
Cancer Institute of China Medical University, Shenyang.
Y
Y
Xin
D
D
Wu
F
F
Zhao
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000556:secondary; D000782:Aneuploidy; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008113:Liver Neoplasms / Q000378:metabolism* / Q000556:secondary; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000556:secondary; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53