Recurrent triploidy of maternal origin.
We report the occurrence of triploid preimplantation embryos following in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in a woman with two previously-identified triploid conceptuses which spontaneously underwent fetal demise at 10 and 23 weeks' gestation. An error in maternal meiosis II is proposed as the most likely cause.
Reproductive Genetics and Reproductive Endocrinology, Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL, USA. epergame@nmh.org
E
E
Pergament
E
E
Confino
J X
JX
Zhang
L
L
Roscetti
P
P
Xien Chen
D
D
Wellman
D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D001755:Blastocyst / Q000502:physiology; D003582:Cytogenetics; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008540:Meiosis; D009630:Nondisjunction, Genetic; D009866:Oogenesis / Q000235:genetics*; D011123:Polyploidy; D011247:Pregnancy; D019836:Preimplantation Diagnosis