Deconstructing Mendel: new paradigms in genetic mechanisms.
As knowledge of the mechanisms of genetic action expands, this new information must be incorporated into the whole. The result is that old concepts are modified or deleted or new paradigms are created. The authors review advances in the understanding of traditional and nontraditional inheritance, including genomic imprinting and mitochondrial inheritance.
Department of Medical Genetics, University of Alberta, Edmonton. dawna.gilchrist@ualberta.ca
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D004272:DNA, Mitochondrial / Q000235:genetics; D005111:Extrachromosomal Inheritance / Q000235:genetics; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005826:Genetics, Medical; D015894:Genome, Human; D018392:Genomic Imprinting / Q000235:genetics; D006801:Humans; D017240:Mitochondrial Myopathies / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000235:genetics; D019683:Penetrance
D004272:DNA, Mitochondrial