[Antiandrogen treatment for nude mice model with ectopic transplanted human HCC].
OBJECTIVE
To investigate the effect of antiandrogen on hepatocellular carcinoma (HCC).


METHODS
Nude mice model with orthotopic transplanted human HCC was constructed and the androgen receptor (AR) in tumor and surrounding liver tissue was assayed dynamically. Nude mice with ectopic transplanted HCC were treated with flutamide (blocker of AR) at two different dosages (Group F1, F2), normal saline(Group C), and anticancer drug(Group M). The effect of treatments was compared among the groups.


RESULTS
The quantity of AR in nucleus and cytoplasm in tumor and tumor-surrounding tissue decreased with the increasing size of tumor in proper order. AR in tumor was significantly less in F1 and F2 groups than in other groups. The tumor weight of group F1, F2 and C had no significant difference (1.36 +/- 0.82 g, 2.66 +/- 1.40 g, 1.66 +/- 0.79 g, respectively), but was significantly higher than that of group M.


CONCLUSIONS
Androgen may play a role at the initial stage of hepatocarcinogenesis, and antiandrogen therapy may be ineffective in the established tumor.
Division of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou.
L
L
Liang
M
M
Lu
J
J
Huang
D000726:Androgen Antagonists / Q000627:therapeutic use*; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D005485:Flutamide / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011944:Receptors, Androgen / Q000378:metabolism
D000726:Androgen Antagonists; D011944:Receptors, Androgen; D005485:Flutamide