Chromosomal localization of human GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death.
Apoptosis is a tightly regulated mechanism that controls the proliferation of cells in metazoans. In mammals, multiple genes are required to regulate cell death. We have employed a gene expression knockout technique to isolate cell death-related genes. One such gene, gene associated with retinoid-interferon-induced mortality-19 (GRIM-19), is essential for tumor cell death induced by interferon-beta (IFN-beta) and retinoic acid (RA). Here, we describe the localization of GRIM-19 to human chromosome 19p13.2. This region is essential for prostate tumor suppression. Together with its death-inductive role in the IFN-retinoid-regulated pathways and the tumor-suppressive function of this locus, the data suggest that GRIM-19 may be a novel tumor suppressor.
Marlene and Stewart Greenebaum Cancer Center, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA.
N V
NV
Chidambaram
J E
JE
Angell
W
W
Ling
E R
ER
Hofmann
D V
DV
Kalvakolanu
D001943:Breast Neoplasms; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D016373:DNA, Antisense; D005260:Female; D016147:Genes, Tumor Suppressor; D015698:Genomic Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016899:Interferon-beta / Q000494:pharmacology*; D007621:Karyotyping; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D016373:DNA, Antisense; D014212:Tretinoin; D016899:Interferon-beta