[Nuclear steroid hormone receptors as possible target molecule for endocrine disruptant].
Endocrine disruptant is supposed to act as a ligand to modulate a certain set of receptors. One class of the candidate receptors is the nuclear receptor superfamily. This family compromises nearly hundred members in human including steroid/thyroid hormones, vitamin A and D, other fat-soluble compounds nuclear receptors, and a subfamily of orphan receptors, whose ligands have not yet been identified. The nuclear receptors regulate transcription of target genes as ligand-inducible transcription factors. In this review, the functions of nuclear receptors are described in terms of transcriptional controls, and a possible target molecule for endocrine disruptants is discussed.
Kato
S
S
Institute of Molecular and Cellular Biosciences, University of Tokyo.
D004247:DNA / Q000378:metabolism; D004147:Dioxins / Q000378:metabolism; D004703:Endocrine System / Q000187:drug effects; D006801:Humans; D008024:Ligands; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000502:physiology; D011987:Receptors, Steroid / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors; D014158:Transcription, Genetic
D004147:Dioxins; D008024:Ligands; D018336:Receptors, Aryl Hydrocarbon; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D014157:Transcription Factors; D004247:DNA