Immunoadsorption in Goodpasture's syndrome.
Patients with Goodpasture's syndrome presenting with dialysis-dependent end-stage renal failure at diagnosis almost never regain independent renal function. We report a patient with a 100% crescentic lesion in whom reversal of dialysis dependence was achieved by immunoadsorption together with immunosuppression. In a second patient, early initiation of immunoadsorption was able to completely restore normal renal function as early as 1 month after the start of treatment. These data give evidence of the use of immunoadsorption as a hopeful alternative to conventional plasma exchange in patients with Goodpasture's syndrome showing advanced renal failure.
Departments of Internal Medicine I, University of Vienna, Vienna, Austria. klaus.laczika@akh-wien.ac.at
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Laczika
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Knapp
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Derfler
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Soleiman
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Hörl
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Druml
D000293:Adolescent; D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology / Q000628:therapy*; D001323:Autoantibodies / Q000097:blood; D001485:Basement Membrane / Q000276:immunology; D005260:Female; D006801:Humans; D007163:Immunosorbent Techniques; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007678:Kidney Glomerulus / Q000276:immunology; D010951:Plasma Exchange
D001323:Autoantibodies; D007166:Immunosuppressive Agents