[The effect of antibody against vascular endothelial growth factor (VEGF) on tumor metastasis].
OBJECTIVE
To study whether manipulation of angiogenesis with antibody against vascular endothelial growth factor (VEGF) may interrupt the tumor growth and metastasis.


METHODS
IV TA2MA 891 is a murine spontaneous breast cancer with high rate of metastasis in lung in (TA2x615) F1 mice, and it was chosen as an animal model in this study because of the high expression of VEGF in primary tumor as well as in lung metastatic tumor. The mice were injected with anti-VEGF polyclonal antibody at a dose of 200 micrograms/mouse/day from day 9 to 23 following s.c. tumor inoculation and sacrificed on day 26.


RESULTS
The growth of primary tumor was inhibited by 44.0% and the number and size of metastatic foci in the lungs were inhibited by 73.0% and 83.7% respectively.


CONCLUSIONS
The antibody against human VEGF may be a potentially effective antimetastasis agent for the treatment of patients with lung metastasis.
Beijing Institute for Cancer Research, Beijing Medicol University.
G
G
Wang
Z
Z
Yang
C
C
Shou
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use; D016228:Endothelial Growth Factors / Q000276:immunology*; D005260:Female; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D008222:Lymphokines / Q000276:immunology*; D008325:Mammary Neoplasms, Experimental / Q000473:pathology* / Q000628:therapy; D051379:Mice; D009368:Neoplasm Transplantation; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D000906:Antibodies; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors