Antimetastatic action of a new analog of dacarbazine in mice bearing Lewis lung carcinoma.
We report the selective antimetastatic properties of 3-(3,3-dimethyl-1-triazenyl)-5-methyl-4,5-dihydroisoxazole in the murine transplantable tumor model Lewis lung carcinoma. The compound verifies a previous study on the correlation of antimetastatic, antitumor and cytotoxic properties of aryl- and heteroaryltriazenes with their Electron Ionization Mass Spectrometry (EI-MS) behavior. The new analog of dacarbazine exhibits a selective antimetastatic activity accompanied by limited thymus toxicity. The mechanism of action is unclear nevertheless any antiproliferative or cytotoxic effect is excluded.
Department of Biomedical Sciences and Technologies, University of Udine, Italy. LPerissin@makek.dstb.uniud.it
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L
Perissin
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Facchin
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Bedini
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Diamantini
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Tontini
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Tarzia
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000556:secondary; D002455:Cell Division / Q000187:drug effects; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D014226:Triazenes / Q000494:pharmacology*
C412012:3-(3,3-dimethyl-1-triazenyl)-5-methyl-4,5-dihydroisoxazole; D018906:Antineoplastic Agents, Alkylating; D014226:Triazenes; D003606:Dacarbazine