[Fournier's gangrene. A study of 12 patients and a review].
We present the clinicoepidemiological and therapeutic characteristics of 12 patients with Fournier's gangrene. The mean age of the patients was 66 years and all had a known predisposing factor for the disease. In all cases there was a predominance of mixed flora (four Gram-positive cocci, nine Gram-negative bacilli and ten anaerobic pathogens), with only one case of bacteremia reported. Initial surgery was conducted and was complemented by antimicrobial administration (imipenem, cefotaxime, clindamycin, penicillin and gentamicin alone and in combination) and local treatment with sugar and povidone-iodine. Hyperbaric oxygen was not used in any cases. At the end of treatment a mesh graft could be applied in 11 patients, all of whom showed an excellent functional and aesthetic recovery. The mean time of hospital stay was lengthy (49 days). The good evolution of the lesions after starting the local treatments with the sugar povidone-iodine combination should be emphasized.
Unidad de Enfermedades Infecciosas, Hospital Universitario La Fe, Avda. Campanar 21, 46009 Valencia.
V
V
Navarro
M
M
Salavert
C
C
Campo
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D002439:Cefotaxime / Q000008:administration & dosage / Q000627:therapeutic use; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D018934:Fournier Gangrene / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D011206:Povidone-Iodine / Q000627:therapeutic use; D012611:Scrotum / Q000382:microbiology / Q000601:surgery; D013395:Sucrose / Q000627:therapeutic use; D013518:Surgery, Plastic
D005839:Gentamicins; D010406:Penicillins; D002981:Clindamycin; D013395:Sucrose; D015378:Imipenem; D011206:Povidone-Iodine; D002439:Cefotaxime