Parallel synthesis and evaluation of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines as Na+/K+ ATPase inhibitors.
A series of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines was prepared using solution-phase, parallel synthesis and evaluated for Na+/K+ ATPase inhibition.
Blass
B E
BE
Procter & Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. blassbe@pg.com
Huang
C T
CT
Kawamoto
R M
RM
Li
M
M
Liu
S
S
Portlock
D E
DE
Rennells
W M
WM
Simmons
M
M
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D007700:Kinetics; D008968:Molecular Conformation; D015394:Molecular Structure; D009206:Myocardium / Q000201:enzymology; D012508:Sarcolemma / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D000588:Amines; D004791:Enzyme Inhibitors; D007093:Imidazoles; D007202:Indicators and Reagents; D000254:Sodium-Potassium-Exchanging ATPase