[The clinical immunogenetics of viral hepatitis C in a Caucasoid population of western Siberia].
The analysis of the immunogenetic studies on hepatitis C patients among the Caucasoid population of western Siberia has revealed a significant increase in the detection rate of antigens HLA-A10 and HLA-DR5, the combinations of DR2-DR5, DR5-DR7, DR1-B27 and the complete absence of antigen HLA-DR4, which is indicative of the fact that susceptibility and resistance to the development of the disease is associated with the genes of the main histocompatibility complex. In hepatitis of mixed etiology, B and C, a significant increase in the occurrence of HLA antigens: -A1, -B8, -DR1 and -DR3, as well as the combinations of A1-DR1, A1-DR3, A3-DR3, A9-A10, DR1-DR3, B8-DR3 is noted; at the same time a decrease in the occurrence of antigen DR4 and its combination with antigen HLA-A2 is observed.
Tolokonskaia
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NP
Medical Institute, Institute of Clinical Immunology, Novosibirsk, Russia.
Konenkov
V I
VI
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D005260:Female; D005828:Genetics, Population; D005838:Genotype; D006680:HLA Antigens / Q000097:blood / Q000235:genetics; D006526:Hepatitis C / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007125:Immunogenetics; D008297:Male; D008875:Middle Aged; D012800:Siberia; D044465:White People / Q000235:genetics*
D006680:HLA Antigens