[Deletion of MTS1/p16 gene in endometrial carcinoma].
OBJECTIVE
To investigate the possible relationship between deletion of MTS1/p16 gene and progression of endometrial carcinoma.


METHODS
Thirty two primary endometrial carcinoma, 7 tumor-adjacent endometrial tissue and 10 normal endometrial tissue specimens were examined for homozygous deletion of MTS1/p16 gene by polymerase chain reaction-based analysis.


RESULTS
Of 32 endometrial cancer specimens, 6(18.8%) showed homozygous deletion of MTS1/p16 gene. No deletion was detected in the tumor-adjacent and normal endometrial tussues. Nor was it detected in well differentiated endometrial carcinoma.


CONCLUSIONS
Deletion of MTS1/p16 gene might contribute to the progression of endometrial carcinoma and could be served as indicator for predicting prognosis.
Zhou
C
C
Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Sun
J
J
Lu
S
S
D000230:Adenocarcinoma / Q000235:genetics*; D018196:Carcinoma, Adenosquamous / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D019942:Genes, p16; D006801:Humans; D016133:Polymerase Chain Reaction