Survivin structure: crystal unclear.
The recent X-ray structures of the anti-apoptotic protein survivin reveal two different dimeric interfaces. More experiments are needed to determine the biologically relevant dimer interface and to probe survivin function on the basis of its structure.
Y
Y
Shi
D000818:Animals; D017209:Apoptosis; D001665:Binding Sites; D002614:Chelating Agents / Q000378:metabolism; D018360:Crystallography, X-Ray; D019281:Dimerization; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D051379:Mice; D008869:Microtubule-Associated Proteins; D008958:Models, Molecular; D009363:Neoplasm Proteins; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000077022:Survivin; D015032:Zinc / Q000378:metabolism
C107489:BIRC5 protein, human; D002614:Chelating Agents; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011506:Proteins; D000077022:Survivin; D015032:Zinc