Methamphetamine selectively alters brain glutathione.
As methamphetamine-induced neurotoxicity has been proposed to involve oxidative stress, reduced and oxidized glutathione (GSH and GSSG, respectively), vitamin E and ascorbate were measured in the striata of rats killed 2 or 24 h after a neurotoxic regimen of methamphetamine. At 2 h, methamphetamine increased GSH and GSSG (32. 5% and 43.7%, respectively) compared to controls at 2 h. No difference was seen in glutathione at 24 h, and in vitamin E and ascorbate at either time point. These findings indicate selectivity of methamphetamine for the glutathione system and a role for methamphetamine in inducing oxidative stress.
Program in Basic and Clinical Neuroscience, Department of Psychiatry, Case Western Reserve University, 44106, Cleveland, OH, USA.
C
C
Harold
T
T
Wallace
R
R
Friedman
G
G
Gudelsky
B
B
Yamamoto
D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D005978:Glutathione / Q000032:analysis*; D019803:Glutathione Disulfide / Q000032:analysis; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D014810:Vitamin E / Q000032:analysis
D014810:Vitamin E; D008694:Methamphetamine; D005978:Glutathione; D001205:Ascorbic Acid; D019803:Glutathione Disulfide