The effect of SK-896 on post-operative ileus in dogs: gastrointestinal motility pattern and transit.
The aim of this study was to investigate the effect of SK-896 (Phe-Val-Pro-Ile-Phe-Thr-Try-Gly-Glu-Leu-Gln-Arg-Leu-Gln-Glu-Lys-Glu- Arg-Asn-Lys-Gly-Gln-Hse), a new motilin analogue, on gastrointestinal motility and transit in dogs with post-operative ileus, and to compare the effects of this agent on these parameters with the effects of prostaglandin F(2alpha), a well-known gastroprokinetic agent. We used chronically implanted force transducers to measure motility and radiography of radio-opaque markers to measure transit. Infusion of SK-896 1 microgram/kg/h, for 20 min twice a day induced interdigestive migrating contractions-like motility. Infusion of prostaglandin F(2alpha), 20 microgram/kg/h, for 1 h twice a day induced continuous contractions in the distal part of the small intestine. The time of first appearance of interdigestive migrating contractions in the stomach (gastric-interdigestive migrating contractions) and the gastric emptying time of the solid marker with the administration of SK-896 were significantly less than those noted with the administration of prostaglandin F(2alpha). It appears that gastric-interdigestive migrating contractions play an important role in the transit of substances, especially solid substances, in the gastrointestinal tract. We conclude that SK-896, which induced gastric-interdigestive migrating contractions, is effective to induce early recovery from post-operative ileus.
Tsukamoto
K
K
Central Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Siosaki Hokusei-cho, Inabe-gun, 511-0406, Mie, Japan. k_tsukamoto@mb4.skk-net.com
Mizutani
M
M
Yamano
M
M
Tagi
Y
Y
Takeda
M
M
D000595:Amino Acid Sequence; D000818:Animals; D004064:Digestive System / Q000187:drug effects / Q000503:physiopathology; D013505:Digestive System Surgical Procedures; D004285:Dogs; D005769:Gastrointestinal Motility / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects; D007415:Intestinal Obstruction / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008969:Molecular Sequence Data; D009037:Motilin / Q000031:analogs & derivatives / Q000494:pharmacology*; D016065:Myoelectric Complex, Migrating / Q000187:drug effects; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors
C414785:SK896; D009037:Motilin