Habitual smoking causes an abnormality in platelet thromboxane A2 metabolism and results in an altered susceptibility to aspirin effects.
The present study investigates the effects of aspirin (100 mg every second day for 14 days) on platelet function in nine healthy non-smokers and in nine healthy habitual smokers. There was a significantly (P < 0.05) stronger inhibition of collagen (0.6 microgram/ml)- and ADP (2 microM)-induced platelet aggregation by aspirin in smokers as compared to non-smokers. This difference occurred in the presence of an almost complete (> 95%) inhibition of thromboxane A2 (TXA2) synthesis in both groups. The platelet capacity to generate TXA2 in vitro was significantly reduced in smokers, urinary excretion of TXA2, however, was significantly increased. Thus, the better susceptibility of smokers to anti-aggregatory effects of aspirin is very likely to be related to a chronic smoking-induced alteration of platelet TXA2 system. Cessation of smoking should, therefore, be encouraged.
Institut für Pharmakologie und Klinische Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Germany.
A A
AA
Weber
S
S
Liesener
A
A
Schanz
T
T
Hohlfeld
K
K
Schrör
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D003094:Collagen / Q000494:pharmacology; D011464:Epoprostenol / Q000652:urine; D004912:Erythrocytes; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D012907:Smoking / Q000009:adverse effects / Q000097:blood* / Q000378:metabolism; D013928:Thromboxane A2 / Q000096:biosynthesis* / Q000097:blood / Q000652:urine; D013931:Thromboxanes / Q000652:urine
D013931:Thromboxanes; D013928:Thromboxane A2; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003094:Collagen; D011464:Epoprostenol; D001241:Aspirin