Efficient synthesis of rhodamine conjugates through the 2'-position.
Reaction of substrates containing primary amines with rhodamine 2'-esters cleanly produces fluorescent rhodamine 2'-amide conjugates at ambient temperature. Only primary amines react with the esters under these conditions. Chemoselectivity can thus be achieved in substrates containing different types of amines.
Department of Organic Chemistry, Abbott Laboratories, Abbott Park, IL 60064-6016, USA. maciej.adamczyk@abbott.com
M
M
Adamczyk
J
J
Grote
D000577:Amides; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D004952:Esters; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D012235:Rhodamines / Q000138:chemical synthesis* / Q000737:chemistry; D018629:Spectrometry, Mass, Secondary Ion; D013329:Structure-Activity Relationship
D000577:Amides; D004952:Esters; D007202:Indicators and Reagents; D012235:Rhodamines