[Effect of the soluble immunocomplexes on the pathogenesis of hemorrhagic fever with renal syndrome].
OBJECTIVE
To determine the effect of the soluble immunocomplexes on the pathogenesis of hemorrhagic fever with renal syndrome (HFRS).


METHODS
The soluble immunocomplex (IC) consisting of HFRS virus antigen and antibody was prepared previously in vitro, and was intravenously injected into BALB/c mice. The localization of IC in the tissues of mice was investigated by immunohistochemical method ABC.


RESULTS
The results showed that 24 hours after injection, ICs were localized mostly in the blood vessels, such as the liver sinusoids, the splenic sinuses, the blood vessels of the mucosa and submucosa of the intestine, and the capillaries of the renal glomeruli, etc. 48 hours later or more, IC localized primarily on the parachymal cells, e.g., the hepatocytes, the epithelial cells of the renal tubules as well as some epithelial cells of the ducts and alveoli of some glands (submandular glands, pancreas). The cells degenerated in the areas with IC, especially in the hepatocytes and epithelial cells of renal tubules. These lesions were very similar to the pathological changes of the HFRS' patients, and were not found in patients injected with other IC.


CONCLUSIONS
The soluble IC of HFRS can cause direct tissue injury in the HFRS.
Huang
X
X
Department of Pathology, Basic Medical Sciences of Fourth Military Medical University, Xi'an.
Liu
Y
Y
Zhang
Y
Y
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000209:etiology / Q000276:immunology*; D007668:Kidney / Q000276:immunology*; D008099:Liver / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000936:Antigen-Antibody Complex