[The clinicopathological and immunophenotypical features of 162 cases of gastrointestinal stromal tumor].
OBJECTIVE
To demonstrate the clinicopathological and immunophenotypical features of gastrointestinal stromal tumor (GIST).


METHODS
One hundred and sixty-two cases of GIST were retrospectively studied. Among them, forty-six cases were immunostained using antibodies against vimentin, CD34, muscle specific actin (MSA), smooth muscle actin (SMA), neuron specific enolase(NSE), S-100 protein, synaptophysin (SYN), cytokeratin(CK), CEA, LCA.


RESULTS
Clinically, male patients predominated with a male to female ratio of 3.8:1. The average age was 50 (range 6-74). The most common symptoms were gastrointestinal bleeding and abdominal mass in 45% and 39% of the cases, respectively. The common anatomical locations were stomach (43%), ileum (20%), jejunum (18%). Pathologically, all the tumor arose from the muscular layer. The tumor diameter varied from 0.5 to 43 cm. In 55% of the cases, the tumor was malignant. The main component cell types were spindle and epithelioid in appearance. Immunophenotypically, percentage of positivity for the 10 antibodies was as follows: vimentin, 100% (39/39), CD34, 64% (23/36), MSA, 47% (16/34), SMA, 41% (14/34), NSE, 61% (17/28), S-100 protein, 19% (4/21), SYN, 15% (3/20), CK, CEA, and LCA were negative.


CONCLUSIONS
GIST is the most common mesenchymal tumor of the gastrointestinal tract. Immunostaining confirms that only some of the GIST shows partial differentiation toward smooth muscle, neuron, or both.
Department of Pathology, Chinese PLA General Hospital, Beijing.
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Zhao
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Li
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Wang
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000276:immunology / Q000473:pathology*; D016130:Immunophenotyping; D008297:Male; D008637:Mesenchymoma / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D012509:Sarcoma / Q000276:immunology / Q000473:pathology*; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology*; D017154:Stromal Cells / Q000473:pathology