Selective nuclear export of viral mRNAs in influenza-virus-infected cells.
The NS1A protein of influenza A virus specifically inhibits the cellular machinery that processes the 3' ends of cellular pre-mRNAs by targeting two of the essential proteins of this machinery. Because the virus does not use this cellular machinery to synthesize the 3' poly(A) ends of viral mRNA, the nuclear export of cellular but not viral mRNAs is selectively inhibited.
Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, The University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA.
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D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism* / Q000821:virology; D006801:Humans; D009980:Influenza A virus / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D039102:Poly(A)-Binding Proteins; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000378:metabolism; D039221:mRNA Cleavage and Polyadenylation Factors
C085820:INS1 protein, influenza virus; D009687:Nuclear Proteins; D039102:Poly(A)-Binding Proteins; D012333:RNA, Messenger; D012367:RNA, Viral; D016601:RNA-Binding Proteins; D017361:Viral Nonstructural Proteins; D039221:mRNA Cleavage and Polyadenylation Factors