"...those left behind." Biology and oncology of invasive glioma cells.
Although significant technical advances in surgical and radiation treatment for brain tumors have emerged in recent years, their impact on clinical outcome for patients has been disappointing. A fundamental source of the management challenge presented by glioma patients is the insidious propensity of the malignant cells to invade into adjacent normal brain. Invasive tumor cells escape surgical removal and geographically dodge lethal radiation exposure. Recent improved understanding of the biochemistry and molecular determinants of glioma cell invasion provide valuable insight to the underlying biological features of the disease, as well as illuminating possible new therapeutic targets. Heightened commitment to migrate and invade is accompanied by a glioma cell's reduced proliferative activity. The microenvironmental manipulations coincident to invasion and migration may also impact the glioma cell's response to cytotoxic treatments. These collateral aspects of the glioma cell invasive phenotype should be further explored and exploited as novel antiglioma therapies.
Berens
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Neuro-Oncology Laboratory, Barrow Neurological Institute, Saint Joseph's Hospital and Medical Center, Phoenix, AZ 85013-4496, USA. mberens@chw.edu
Giese
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D000818:Animals; D001253:Astrocytes / Q000473:pathology; D002455:Cell Division; D002465:Cell Movement; D005109:Extracellular Matrix / Q000502:physiology; D005910:Glioma / Q000473:pathology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D009361:Neoplasm Invasiveness
D018960:Hyaluronan Receptors