[The association of sasceptibility of SLE and the gene polymorphism of TNF].
OBJECTIVE
To evaluate the association between the susceptibility of SLE and the gene polymorphism of TNF in Chinese Han population.


METHODS
The single base change polymorphism in both TNF alpha gene and TNF beta gene were analyzed among SLE patients and normal controls by using PCR-SSCP and PCR-RFLP.


RESULTS
No difference of gene or genotype frequencies of TNF alpha was noted in SLE patients and normal controls (P > 0.5), whereas TNF beta * 2 gene frequency increased significantly in SLE patients (SLE patients 65.7%, normal people 54.5%, P < 0.05).


CONCLUSIONS
TNF alpha gene polymorphism has no effect on SLE, but TNF beta * 2 allelic type may be related to the susceptibility of SLE in Chinese Han population to some extent.
Department of Nephology, First Hospital, Beijing Medical University.
Y
Y
Wang
Y
Y
Zhang
S
S
Zhu
D000293:Adolescent; D000328:Adult; D004198:Disease Susceptibility; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008233:Lymphotoxin-alpha / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D008233:Lymphotoxin-alpha; D014409:Tumor Necrosis Factor-alpha