Parasympathetic nerves influence cerebral blood flow during hypertension in rat.
This study tested the hypothesis that cerebral vasodilatation during marked acute hypertension is mediated in part through the influence of parasympathetic nerves from the pterygopalatine ganglia. Blood pressure was increased slowly in anesthetized rats after bilateral transection of the parasympathetic nerves. Cerebral blood flow was measured by laser flowmetry. Acutely hypertensive denervated animals developed significantly less cerebral vasodilatation than did control animals with intact nerves. Thus, parasympathetic vasodilator nerves contribute to vasodilatation seen with acute hypertension.
Department of Neurology, University of Iowa and Department of Veterans Affairs Medical Center, Iowa City 52242, USA. william-talman@uiowa.edu
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D000208:Acute Disease; D000818:Animals; D002560:Cerebrovascular Circulation; D003714:Denervation; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010275:Parasympathetic Nervous System / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D014664:Vasodilation / Q000502:physiology