[Economic analysis versus the principle of guaranteed safety in blood transfusion].
This article shows that policies aimed at reducing risks of infectious agents transmissible through blood unfortunately follow a law of 'diminishing returns': increasing marginal costs have to be devoted for limited reductions in the risks of contamination through blood donations. Therefore, the economic cost-effectiveness analysis is appropriate to identify screening strategies which may minimize costs to reach a certain level of safety. Moreover, economic analysis can contribute to public debates about the level of residual risk that society is willing to accept. Empirical results from French studies about screening for hepatitis C virus (HCV) in individuals who have received blood transfusions and in blood donations are presented to illustrate these points.
Inserm U 379, Institut Paoli-Calmettes, Marseille, France.
J P
JP
Moatti
S
S
Loubière
M
M
Rotily
D001782:Blood Donors; D001803:Blood Transfusion / Q000191:economics* / Q000592:standards; D003362:Cost-Benefit Analysis; D004992:Ethics, Medical; D005602:France / Q000453:epidemiology; D017048:Health Care Costs; D006526:Hepatitis C / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008403:Mass Screening / Q000191:economics* / Q000592:standards; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012449:Safety; D012680:Sensitivity and Specificity; D065227:Transfusion Reaction; D014766:Viremia / Q000097:blood / Q000175:diagnosis / Q000635:transmission
D018937:Hepatitis C Antibodies