[Deregulation of intracellular signal pathways in colorectal carcinoma].
The analysis of the genetic causes of tumor development led to the identification of many genes affected in these diseases, which play a role in the control of cell proliferation and apoptosis. However, these studies also suggested that not all alterations are equal with regard to their effect on tumor growth, and they demonstrated that the deregulation of the classical cytoplasmic cascade made up by Ras-Raf-MEK and ERK plays a critical role in tumor development. These findings also raise the hope that via interference with a single pathway growth of a tumor carrying multiple genetic alterations will be affected.
Institut f. Medizinische Strahlenkunde und Zellforschung (MSZ), Würzburg. troppmair@mail.uni-wuerzburg.de
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D017209:Apoptosis; D017322:Clinical Trials, Phase II as Topic; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D004260:DNA Repair / Q000235:genetics; D006801:Humans; D009154:Mutation; D012106:Research; D015398:Signal Transduction / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000473:pathology