The time-effect relationship of central action in acupuncture treatment for weight reduction.
OBJECTIVE
To study the time-effect relationship of action of acupuncture on the satiety center of ventromedial nucleus of hypothalamus (VMH) in rats with experimental obesity.


METHODS
Microelectrode recording method of nerve cells and stereotaxic technique for brain were adopted with discharge frequency (Hz/s) of nerve impulse in VMH as the index, and the time-effect of acupuncture action in different periods between groups were observed.


RESULTS
Electric activity in acupuncture group was higher than in the obesity model group (P < 0.001) and the normal group (P < 0.01) respectively, and the curve of acupuncture action within 2 hours showed irregular fluctuation.


CONCLUSIONS
Acupuncture can increase excitability of the satiety center, with a better long-term effect.
Second Clinical College of Nanjing University of Traditional Chinese Medicine and Pharmacy.
M
M
Zhao
Z
Z
Liu
J
J
Su
D015670:Acupuncture Therapy; D000818:Animals; D015671:Electroacupuncture; D004594:Electrophysiology; D008297:Male; D009765:Obesity / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014697:Ventromedial Hypothalamic Nucleus / Q000503:physiopathology*; D015431:Weight Loss