[Direct modulatory effects of G proteins on voltage-dependent ion channels of nerve cells].
Neurotransmitters have regulative effects on voltage-dependent ion channels of nerve cells. Recent studies have shown that voltage-dependent channels were modulated by transmitters through direct interactions between G proteins and channels without any known second messengers being involved. This gave us a novel understanding of the relations between G proteins and voltage-dependent ion channels. This article reviews the phenomena, characteristics, and mechanisms about voltage-dependent channels modulated by transmitters through direct effects of G proteins.
Wu
X S
XS
Shanghai Brain Research Institute, Chinese Academy of Sciences.
He
S F
SF
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology
D007473:Ion Channels; D018377:Neurotransmitter Agents; D019204:GTP-Binding Proteins