Evaluation of the antimicrobial property of the stem bark of Picralima nitida (Apocynaceae).
The basic fraction (BF) of the methanol extract of the stem bark of Picralima nitida (family Apocynaceae) exhibited significant antimicrobial activity against a wide range of Gram-positive bacteria and fungi, but limited activity against Gram-negative bacteria. The BF had a similar minimum inhibitory concentration (MIC) for S. aureus to the control drug ampicillin, and lower MIC values against A. flavus and A. niger than those of tiaconazole. Values of the minimum bactericidal concentration (MBC) of the BF against microorganisms tested were generally much higher than those for the control drugs ampicillin and gentamicin. The results suggest that some constituents of the stem bark could be isolated and developed into effective antimicrobial agents.
Department of Pharmaceutical Microbiology and Clinical Pharmacy, Faculty of Pharmacy, University of Ibadan, Nigeria.
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Fakeye
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Itiola
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D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D001407:Bacillus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D014197:Trees
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D010936:Plant Extracts