Peritoneal fluid urea nitrogen and creatinine reference values.
OBJECTIVE
To evaluate urea nitrogen and creatinine levels in peritoneal fluid.


METHODS
We prospectively evaluated 20 consecutive women having radical hysterectomy with lymphadenectomy. On postoperative days 2 and 3, serum, urine, and peritoneal fluid samples were tested for urea nitrogen and creatinine. Using power analysis we calculated an adequate sample size to be 16 patients.


RESULTS
The mean urea nitrogen was 11 mg/dL in serum, 11 mg/dL in peritoneal fluid, and 469 mg/dL in urine. The mean creatinine was .9 mg/dL in serum, 1.0 mg/dL in peritoneal fluid, and 141 mg/dL in urine. Urea nitrogen and creatinine values in peritoneal fluid and serum were essentially identical. Urine urea nitrogen and creatinine values were significantly greater than serum and peritoneal values (47 to 157 times greater) (P < .011). On postoperative days 2 and 3, serial levels of serum, peritoneal fluid, and urine urea nitrogen and creatinine in the same subject showed no significant variation (P ranging from .19 to .31).


CONCLUSIONS
Normal reference values of urea nitrogen and creatinine in peritoneal fluid are equivalent to serum values and significantly less than urine levels.
Manahan
K J
KJ
Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43614-5809, USA.
Fanning
J
J
D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry*; D001806:Blood Urea Nitrogen; D003401:Creatine / Q000032:analysis*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values
D003401:Creatine