Hereditary factors in the development of diabetic renal disease.
The role of genetics in diabetic renal disease has been suspected on the basis of follow-up and familial studies. Barely half of Type 1 patients who develop a diabetic retinopathy also develop nephropathy, and the relative risk of nephropathy for a diabetic proband is around 3 if a sib is affected. Candidate genes for diabetic nephropathy can be divided into two categories: those affecting glucose metabolism in target organs of diabetic microangiopathy, and those affecting renal changes in response to hyperglycaemia. The role of angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been suspected for several years. Evidence of its possible role in the development and progression of diabetic renal disease is presented here.
Marre
M
M
Diabetes Departments, Hôpital Bichat, Paris, France. michel.marre@bch.ap-hop-paris.fr
Hadjadj
S
S
Bouhanick
B
B
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000235:genetics* / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000235:genetics; D006801:Humans; D009679:Nuclear Family; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A