[Effect of the long term administration of bromantan on the reproductive function in rats].
Bromantan is a new psychostimulator possessing actoprotector properties. The drug was administered to rats over two months (males) and two weeks (females) at a daily dose of 30 and 200-mg/kg, and the reproduction function parameters were monitored. Then the experimental animals were coupled and the embryonal characteristics of the breed were determined. Upon termination of the drug administration, the functional state of sperm and the morphology of gonads were studied again. It was found that bromantan (30 mg/kg) unreliably decreases the absolute amount of sperm in males. In females, the drug did not affect the ovary weight coefficient and increased the gestation index. After termination of the drug administration, the ovary weight coefficient increased. Bromantan affected neither the fertilizing capacity of male and female gametes nor the embryonal characteristics of the breed.
Institute of Pharmacology, Volgograd State Medical Academy, Russia.
T V
TV
Khamidova
L I
LI
Bugaeva
I S
IS
Morozov
A A
AA
Spasov
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D005306:Fertilization / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects
D000276:Adjuvants, Immunologic; D011619:Psychotropic Drugs; D000547:Amantadine; C085955:bromantane