Molecular steps of cell suicide: an insight into immune senescence.
The cellular and molecular basis of immune senescence is unclear. A number of mechanisms have been proposed. In this issue of the Journal of Clinical Immunology, some of the mechanisms for various immunologic abnormalities in aging are presented. In this article, various molecular steps of both death receptor and mitochondrial pathways of apoptosis in general are reviewed. In particular, the role of apoptosis in T-cell immune senescence is discussed.
Gupta
S
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Department of Medicine, University of California, Irvine 92697, USA.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D029681:Arabidopsis Proteins; D001426:Bacterial Proteins / Q000502:physiology; D061945:Caspase Inhibitors; D020169:Caspases / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D015853:Cysteine Proteinase Inhibitors / Q000502:physiology; D003574:Cytochrome c Group / Q000378:metabolism; D004579:Electron Transport; D004789:Enzyme Activation; D053222:Fas Ligand Protein; D044943:Fatty Acid Desaturases / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000254:growth & development*; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D008928:Mitochondria / Q000502:physiology; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D019014:fas Receptor / Q000502:physiology
D029681:Arabidopsis Proteins; D001426:Bacterial Proteins; D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; D003574:Cytochrome c Group; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins; D008562:Membrane Glycoproteins; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D044943:Fatty Acid Desaturases; C084083:Fad7 protein, Arabidopsis; D020169:Caspases