Hepatitis C virus and its pathogenesis.
Hepatitis C virus is a major causative agent of chronic hepatitis and the development of hepatocellular carcinoma. However, the roles of this virus in these diseases remain to be clarified, although it is likely that cytotoxic T lymphocytes (CTL) play crucial roles in the clearance of virus-infected cells, thus causing inflammation. In many, cases the clearance is not sufficient to eradicate all infected cells. This may be due to insufficient activation of CTL. In addition, it is also likely that the virus has some mechanism to escape from clearance. One such mechanism may be the suppression of apoptosis by activation of NF-kB or mitogenic function by virus proteins, and these functions may also be linked to the development of hepatocellular carcinoma.
Institute for Virus Research, Kyoto University, Japan. kshimoto@virus.kyoto-u.ac.jp
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Shimotohno
D000818:Animals; D002455:Cell Division / Q000276:immunology; D006224:Cricetinae; D016174:Hepacivirus / Q000472:pathogenicity / Q000502:physiology*; D019698:Hepatitis C, Chronic / Q000209:etiology*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014758:Viral Core Proteins / Q000276:immunology / Q000378:metabolism
D016328:NF-kappa B; D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus