[Gene therapy of tumors of the head and neck: clinical use of the p53 tumor suppressor gene].
Gene therapy involves the introduction of genetic material (DNA) in patient cells, in order to produce therapeutic effect after expression of the new gene. New insights in head and neck tumor etiology and the development of genetic engineering techniques made the gene transfer a reality. This article gives a brief overview of investigations leading to clinical application of gene therapy in head and neck tumors. A good therapeutic response in more than 50% patients has been reported in literature. These results and future potential of gene therapy are discussed.
Klinika za otorinolaringologiju i cervikofacijaluu kirurgiju Medicinskog i Stomatoloskog fakulteta Sveucilista u Zagrebu.
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Grgić
D000818:Animals; D016158:Genes, p53; D015316:Genetic Therapy; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans