Waterhouse-Friderichsen syndrome and bilateral renal cortical necrosis in meningococcal sepsis.
Waterhouse-Friderichsen syndrome and bilateral renal cortical necrosis (BRCN) are rare complications of meningococcal sepsis associated with high mortality rates. We describe a 20-year-old man who presented with a 1-day history of fever, chills, malaise, and vomiting. He collapsed in the emergency room, requiring mechanical ventilation and intravenous vasopressors for resuscitation. He was noted to be anuric, and computed tomography showed adrenal hemorrhage and BRCN. Blood cultures later confirmed Neisseria meningitidis sepsis, and a biopsy confirmed renal cortical infarction. The patient was treated aggressively with intravenous antibiotics, corticosteroids, and immunoglobulins, in addition to plasmapheresis, dialysis, and supportive measures. He recovered his adrenal function and was discharged from the hospital, but he remains dialysis dependent. To our knowledge, this is the first reported case of concomitant Waterhouse-Friderichsen syndrome and BRCN in a patient with meningococcal sepsis.
Department of Medicine, Nephrology Division, University of Texas Medical Branch, Galveston, TX 77555-0562, USA. mlagraha@utmb.edu
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Agraharkar
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Fahlen
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Siddiqui
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Rajaraman
D000328:Adult; D006801:Humans; D007668:Kidney / Q000473:pathology; D007673:Kidney Cortex Necrosis / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D010956:Plasmapheresis; D006435:Renal Dialysis; D014884:Waterhouse-Friderichsen Syndrome / Q000150:complications* / Q000628:therapy