Maturation of cellular Fe-S proteins: an essential function of mitochondria.
Iron-sulfur (Fe-S) cluster-containing proteins perform important tasks in catalysis, electron transfer and regulation of gene expression. In eukaryotes, mitochondria are the primary site of cluster formation of most Fe-S proteins. Assembly of the Fe-S clusters is mediated by the iron-sulphate cluster assembly (ISC) machinery consisting of some ten proteins.
Lill
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Institut für Zytobiologie und Zytopathologie der Philipps-Universität Marburg, Robert-Koch-Str. 5, 35033 Marburg, Germany.
Kispal
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D001692:Biological Transport; D019143:Evolution, Molecular; D006801:Humans; D007506:Iron-Sulfur Proteins / Q000096:biosynthesis* / Q000378:metabolism; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000378:metabolism
D007506:Iron-Sulfur Proteins