Synthesis and hypoglycemic activity of some new flavone derivatives. 2nd communication: 4'-flavonyl-2,4-thiazolidinediones.
A new series of 4'-flavonyl-2,4-thiazolidinedione, 2,4-imidazolidinedione and 2-thiohydantoin derivatives (1-10) were synthesized. Their chemical structures have been elucidated by IR, 1H-NMR, mass spectra and elementary analysis. The synthesized compounds were tested for their insulinotropic effects in INS-1 cells. Inhibitory effects were observed for compounds 1, 2, 6 and 7.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
O
O
Bozdağ
E J
EJ
Verspohl
R
R
Ertan
D002478:Cells, Cultured; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D005419:Flavonoids; D007004:Hypoglycemic Agents; D007328:Insulin; D013844:Thiazoles; D005947:Glucose