Motor cortex excitability in patients with focal epilepsy.
We studied the excitability of the motor cortex using, transcranial magnetic stimulation (TMS) in patients with temporal and extratemporal epilepsy. We applied single and paired-pulse TMS to 15 patients with temporal (n = 7), extratemporal (n = 6) and focal epilepsy lateralised to one hemisphere (n = 2). Patients had no antiepileptic drugs in the last 48 h and were seizure free for 4 h prior to testing. We determined the threshold for EMG responses at rest (RMT), the cortically evoked silent period (CSSP) and intracortical inhibition (ICI, intervals of 2-4 ms) and facilitation (ICF, 7-15 ms) and compared the results to those obtained in 17 normal controls. ICI and ICF was reduced in both hemispheres (P < 0.01. ANOVA) compared to the controls. In the hemisphere of seizure origin ('abnormal') there was a reduction of ICF (P < 0.01) and normal ICI, in the 'normal' hemisphere there was a reduced ICI (P < 0.01) and a slight reduction of ICF (P < 0.05). ICF on the 'abnormal' side was reduced (P < 0.05) compared to the 'normal' hemisphere. RMT was increased in two patients, but group comparison of RMT and CSSP showed no significant differences between patients and controls. The results suggest a remote effect of epileptic activity onto the motor cortex leading to an alteration of activity in local inhibitory circuits.
Werhahn
K J
KJ
Department of Neurology, University of Munich, Germany. werhahnk@ninds.nih.gov
Lieber
J
J
Classen
J
J
Noachtar
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004056:Differential Threshold; D004292:Dominance, Cerebral; D004569:Electroencephalography; D004576:Electromyography; D004827:Epilepsy / Q000503:physiopathology*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D008280:Magnetics; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*; D009433:Neural Inhibition; D010812:Physical Stimulation; D012016:Reference Values; D012146:Rest