Pyrrolo[2,1-d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity.
The title compounds, that hold the deaza skeleton of temozolomide, exhibited potent in vitro antiproliferative activity. An evaluation of such a biological activity indicates that the mode of action of these compounds differs from that of temozolomide and is also mechanistically unrelated to that of any known antitumor drug.
Diana
P
P
Dipartimento Farmacochimico Tossicologico e Biologico, Università di Palermo, Italy.
Barraja
P
P
Lauria
A
A
Almerico
A M
AM
Dattolo
G
G
Cirrincione
G
G
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000494:pharmacology; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000494:pharmacology; D000077204:Temozolomide
D018906:Antineoplastic Agents, Alkylating; D006574:Heterocyclic Compounds, 2-Ring; D003606:Dacarbazine; D000077204:Temozolomide