Early cranial ultrasound changes as predictors of outcome during first year of life in term infants with perinatal asphyxia.
OBJECTIVE
To identify the types of early cranial ultrasound changes that were significant predictors of adverse outcome during the first year of life in asphyxiated term infants.


METHODS
This was a prospective cohort study. Shortly after birth, cranial ultrasonography was carried out via the anterior fontanelles of 70 normal control infants and 104 asphyxiated infants with a history of fetal distress and Apgar scores of less than 6 at 1 and 5 min of life, or requiring endotracheal intubation and manual intermittent positive pressure ventilation for at least 5 min after birth. Neurodevelopmental assessment was carried out on the survivors at 1 year of age.


RESULTS
Abnormal cranial ultrasound changes were detected in a significantly higher proportion (79.8%, or n = 83) of asphyxiated infants than controls (39.5%, or n = 30) (P < 0.0001). However, logistic regression analysis showed that only three factors were significantly associated with adverse outcome at 1 year of life among the asphyxiated infants. These were: (i) decreasing birthweight (for every additional gram of increase in birthweight, adjusted odds ratio (OR) = 0.999, 95% confidence interval (CI) 0.998, 1.000; P = 0.047); (ii) a history of receiving ventilatory support during the neonatal period (adjusted OR = 8.3; 95%CI 2.4, 28.9; P = 0.0009); and (iii) hypoxic-ischaemic encephalopathy stage 2 or 3 (adjusted OR = 5.8; 95%CI 1.8, 18.6; P = 0.003). None of the early cranial ultrasound changes was a significant predictor.


CONCLUSIONS
Early cranial ultrasound findings, although common in asphyxiated infants, were not significant predictors of adverse outcome during the first year of life in asphyxiated term infants.
Department of Paediatrics, Faculty of Medicine, University Kebangsaan, Kuala Lumpur, Malaysia. nyboo@mail.hukm.ukm.my
N Y
NY
Boo
V
V
Chandran
M A
MA
Zulfiqar
S M
SM
Zamratol
M K
MK
Nyein
M S
MS
Haliza
M S
MS
Lye
D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000401:mortality* / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D015331:Cohort Studies; D004453:Echoencephalography; D005260:Female; D005316:Fetal Distress / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D015996:Survival Rate; D013997:Time Factors