[Comparative analysis of the cardioprotective effect of antioxidant dibunol and agonists of mu- and delta-opioid receptors during oxidative stress].
Upon intravenous injection of the delta-opioid receptor agonists, the isolated perfused rat heart became resistant to free radical damage. The cardioprotector activity of the delta-receptor agonists is more pronounced than that of the antioxidant dibunol. Both dibunol and the delta-receptor agonists favored a decrease in the level of diene conjugates in myocardium. Stimulation of the mu-opioid receptors did not change the resistance of rat heart to the oxidative stress.
Department of Experimental Cardiology, Russian Academy of Medical Sciences, Tomsk, Russia.
L N
LN
Maslov
T Iu
TIu
Rebrova
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008024:Ligands; D015227:Lipid Peroxidation / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists*; D017450:Receptors, Opioid, mu / Q000819:agonists*
D000975:Antioxidants; D008024:Ligands; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D002084:Butylated Hydroxytoluene