A specific role for cyclin D1 in mammary gland development.
Cyclin D1 is a critical component of the core cell cycle machinery. Mice lacking cyclin D1 develop mammary glands that fail to undergo normal lobuloalveolar proliferation during pregnancy. Thus, cyclin D1 seems to play a critical role in pregnancy-induced proliferation of mammary epithelium. Cyclin D1 also participates in neoplasia, as the majority of human mammary carcinomas contain elevated levels of this cyclin.
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA.
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Sicinski
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Weinberg
D000818:Animals; D019938:Cyclin D1 / Q000502:physiology*; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000196:embryology* / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011247:Pregnancy
D019938:Cyclin D1