[Debulking operation for non-small cell lung cancer].
OBJECTIVE
To assess effectiveness and influencing factors of debulking operation for non-small cell lung cancer.


METHODS
The cumulative survival and its influencing factors were analyzed and compared by the Kaplan-Meier and Cox model of SPSS for Windows in 244 patients received debulking operation and 364 received thoracotomy.


RESULTS
The 1, 3, 5-year cumulative survival of patients treated with debulking operation was 56.9%, 20.6%, 17.5% respectively while that received thoracotomy was 41.1%, 7.8%, 5.3%, respectively (debulking vs thoracotomy, Breslow = 27.55, P < 0.0001). Multivariate analysis showed that the debulking operation or thoracotomy (B = -0.4600, P < 0.0001) and postoperative adjuvant therapies (B = -0.1059, P = 0.0216) were the most important influencing factors on the cumulative survival.


CONCLUSIONS
Tumor debulking operation is an important treatment for stage III, IV non-small cell lung cancer. With postoperative adjuvant chemoradiotherapy better survival can be achieved.
Wu
Y
Y
Department of Thoracic Surgery, Tumor Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou.
Huang
Z
Z
Rong
T
T
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods*; D016016:Proportional Hazards Models; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate