Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor.
We describe a healthy peripheral blood stem cell (PBSC) donor who developed a cutaneous reaction, erythema exsudativum multiforme, during the administration of granulocyte colony-stimulating factor (G-CSF) for mobilization. The cutaneous lesions were located on his hips, apart from the site of G-CSF injection. Treatment with topical corticosteroid was commenced, and the lesions resolved completely within a week. Adverse cutaneous reactions induced by G-CSF have been reported infrequently in healthy donors. Further documentation of cases and their full evaluation will be of great importance for both physicians and PBSC donor.
Keio Bone Marrow Transplant Program, Division of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
T
T
Mori
N
N
Sato
R
R
Watanabe
S
S
Okamoto
Y
Y
Ikeda
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D001782:Blood Donors; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000188:drug therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006615:Hip / Q000473:pathology; D006801:Humans; D007564:Japan; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000188:drug therapy; D014184:Transplantation, Homologous / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D016179:Granulocyte Colony-Stimulating Factor