Trends over time in Helicobacter pylori gastritis in Kenya.
OBJECTIVE
There is increasing evidence to link infection of the gastric mucosa by Helicobacter pylori with the subsequent development of gastric cancer. This study was undertaken to document the progression of H. pylori gastritis in a rural Kenyan population with a moderate gastric cancer risk.


METHODS
Biopsy follow-up study of 51 H. pylori-positive patients over an average of 5.5 years.


RESULTS
In the study group, the number of individuals with moderate to severe atrophy rose from 17 (33%) to 22 (43%), an annual increase of 1.8% [95% confidence interval (CI) -0.9% to 4.4%]. There was significant progression of atrophy (P< 0.05) in those with low overall scores for graded morphological variables at initial endoscopy. Intestinal metaplasia did not progress; indeed four out of 12 patients initially diagnosed with intestinal metaplasia showed no evidence of it in their follow-up biopsies.


CONCLUSIONS
H. pylori gastritis with atrophy may provide a suitable environment within the gastric mucosa for the development of gastric cancer but it is likely that other factors in this population determine further progress towards dysplasia and cancer.
McFarlane
G A
GA
PCEA Chogoria Hospital, Kenya. G.McFarlane@talk21.com
Wyatt
J
J
Forman
D
D
Lachlan
G W
GW
D000328:Adult; D001707:Biopsy, Needle; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000473:pathology; D005757:Gastritis, Atrophic / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D007630:Kenya; D008297:Male; D008679:Metaplasia; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology*