Synthesis of RGD containing peptides and their vasodilation effect.
APLRV, SLRR, RGDS, and RGDF were synthesized by use of the solution method via the corresponding protective intermediates. After fragment condensation and deprotection, APLRVRGDS, APLRVRGDF, SLRRRGDS, and SLRRRGDF were obtained. The effect of these RGD containing peptides on rat aortic strips pretreated with noradrenaline (NE) were observed. The relaxing extents of contracted strips for them at three doses (10(-5) mol/L, 10(-6) mol/L and 10(-7) mol/L) indicated that, in a few cases, this kind of combination of these fragments may enhance the desirable activity.
Ming
Z
Z
College of Pharmaceutical Sciences, Beijing Medical University, P. R. China.
Chao
W
W
Jian
Y
Y
Shiqi
P
P
D000595:Amino Acid Sequence; D000818:Animals; D001011:Aorta / Q000187:drug effects; D001681:Biological Assay; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
D009842:Oligopeptides; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; C047981:arginyl-glycyl-aspartic acid; D009638:Norepinephrine