Neutralization of anti-alphaGalactosyl antibodies without immunosuppression prevents hyperacute rejection but not acute vascular rejection of pig organs transplanted into baboons.
Manez
R
R
Juan Canalejo Medical Center, Coruña, Spain.
Crespo
F
F
Gonzalez
E
E
Centeno
A
A
Juffe
A
A
Arnal
F
F
Cozzi
E
E
White
D J
DJ
Duthaler
R
R
Kinzy
W
W
Oehrlein
R
R
Katopodis
A
A
D000208:Acute Disease; D000818:Animals; D030801:Animals, Genetically Modified; D000910:Antibodies, Heterophile / Q000097:blood*; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology; D018958:CD55 Antigens / Q000235:genetics / Q000276:immunology; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D004187:Disaccharides / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D010215:Papio; D013552:Swine; D014183:Transplantation, Heterologous / Q000276:immunology*
D000910:Antibodies, Heterophile; D015703:Antigens, CD; D018958:CD55 Antigens; D003176:Complement C3; D003181:Complement C4; D004187:Disaccharides; D007075:Immunoglobulin M; C055075:galactosyl-(1-3)galactose