[Nuclear matrix protein pattern in human hepatocellular carcinoma].
OBJECTIVE
To compare nuclear matrix proteins of normal liver with those of hepatocellular carcinoma (HCC) to see whether there are HCC-specific proteins.


METHODS
Using high resolution two-dimensional polyacrylamide gel electrophoresis, the nuclear matrix proteins of 3 normal livers and 8 HCC were compared.


RESULTS
There was a high degree of similarity between nuclear proteins of normal liver and those of HCC. Four HCC-specific nuclear matrix proteins were identified. Among them, one protein(Mr: 62,000; pI: 5.3) appeared in all tumor samples. The other three proteins appeared in most of the 8 HCC cases. These proteins were not detected in 3 normal livers.


CONCLUSIONS
There are HCC-specific nuclear matrix proteins which may be related to the etiology and pathogenesis of HCC.
Department of Anatomical and Cellular Pathology, Chinese University of Hongkong, Hongkong.
S
S
Wu
Z
Z
Liu
Y Q
YQ
Qiu
D034961:Antigens, Nuclear; D006528:Carcinoma, Hepatocellular / Q000737:chemistry*; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D008113:Liver Neoplasms / Q000737:chemistry*; D009687:Nuclear Proteins / Q000302:isolation & purification*
D034961:Antigens, Nuclear; D009687:Nuclear Proteins