[Changes of plasma nitric oxide and endothelin levels in normal pregnant women and pregnancy induced hypertension].
OBJECTIVE
To investigate the relationship of nitric oxide (NO), endothelin-1 (ET-1) levels and pregnancy induced hypertension (PIH).


METHODS
60 patients with PIH, 45 normal pregnant women and 15 normal non-pregnant women were studied. Plasma NO levels were determined. The stable metabolic product NO2-/NO3- of NO was letermined by Griess reaction. Plasms ET-1 levels were measured with radioimmunoassay.


RESULTS
The NO2-/NO3- levels of the normal pregnancy group were significantly higher than those of the control group (P < 0.01), particularly in the second trimester of pregnancy. The NO2-/NO3- level of PIH was significantly lower in maternal plasma than that of the last trimester of normal pregnancy (P < 0.01) and nonpregnancy (P < 0.05), and it decreased with the disease development. In severe PIH the umbilical venous blood NO2-/NO3- level was significantly lower than that in the normal term pregnancy group (P < 0.01). The maternal plasma ET-1 level in PIH was significantly higher than that in the normal term pregnancy and control groups (P < 0.01).


CONCLUSIONS
PIH might be related to decreasing synthesis and release of NO, and increasing ET-1 production.
Second Teaching Hospital, Bethune University of Medical Sciences, Changchun.
Y
Y
Zhao
W
W
Zhang
L
L
Wang
D000328:Adult; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*
D019332:Endothelin-1; D009569:Nitric Oxide