Biogerontology: the next step.
After a long period of collecting empirical data describing the changes in organisms, organs, tissues, cells, and macromolecules, biogerontological research is now able to develop various possibilities for intervention. Because aging is a stochastic and nondeterministic process characterized by a progressive failure of maintenance and repair, it is reasoned that gene involved in homeodynamic repair pathways are the most likely candidate gerontogenes. A promising approach for the identification of critical gerontogenic processes is through the hormesis-like positive effects of mild stress. Stimulation of various repair pathways by mild stress has significant effects on delaying the onset of various age-associated alterations in cells, tissues, and organisms.
Danish Centre for Molecular Gerontology, Department of Molecular and Structural Biology, University of Aarhus, Denmark. rattan@imsb.au.dk
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D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence; D006801:Humans