Polycystin expression in the kidney and other tissues: complexity, consensus and controversy.
PKD1, the major gene mutated in autosomal dominant polycystic kidney disease, was identified in 1994, and fully sequenced in 1995. The protein which it encodes, polycystin-1, is the first member of a new family of proteins, whose functions presently remain unclear. This review seeks to highlight the difficulties researchers studying polycystin-1 have faced and to summarize the current areas of consensus and controversy between different groups, particularly with regard to the expression pattern, subcellular location and biochemical characterization of polycystin-1. Where relevant, more recent data regarding polycystin-2, the protein encoded by PKD2, will also be discussed.
MRC Molecular Haematology Unit, Institute of Molecular Medicine, University of Oxford, Headington, Oxon., UK.a.ong@sheffield.ac.uk
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D000328:Adult; D000818:Animals; D002462:Cell Membrane / Q000737:chemistry; D015870:Gene Expression; D005865:Gestational Age; D006801:Humans; D007668:Kidney / Q000737:chemistry* / Q000196:embryology / Q000254:growth & development; D052177:Kidney Diseases, Cystic / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D011506:Proteins / Q000032:analysis / Q000235:genetics*; D050396:TRPP Cation Channels
D011506:Proteins; D050396:TRPP Cation Channels