Mismatch repair proteins and mitotic genome stability.
Mismatch repair (MMR) proteins play a critical role in maintaining the mitotic stability of eukaryotic genomes. MMR proteins repair errors made during DNA replication and in their absence, mutations accumulate at elevated rates. In addition, MMR proteins inhibit recombination between non-identical DNA sequences, and hence prevent genome rearrangements resulting from interactions between repetitive elements. This review provides an overview of the anti-mutator and anti-recombination functions of MMR proteins in the yeast Saccharomyces cerevisiae.
Harfe
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BD
Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.
Jinks-Robertson
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S
D000251:Adenosine Triphosphatases; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D005092:Exonucleases / Q000502:physiology; D005821:Genetic Techniques; D016678:Genome; D006801:Humans; D008938:Mitosis; D000070956:MutL Proteins; D051719:MutS DNA Mismatch-Binding Protein; D009154:Mutation; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D011506:Proteins / Q000502:physiology*; D011995:Recombination, Genetic; D015003:Yeasts / Q000502:physiology
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C074770:MutL protein, E coli; D018809:Proliferating Cell Nuclear Antigen; D011506:Proteins; D005092:Exonucleases; D000251:Adenosine Triphosphatases; D000070956:MutL Proteins; D051719:MutS DNA Mismatch-Binding Protein; C497175:MutS protein, E coli