[The correlation between p170, p26 and multidrug resistance in refractory/relapse acute leukemia].
OBJECTIVE
To explore the role of two membrane proteins, p170 and p26, in clinical drug resistance and their correlation.


METHODS
The expression of p170 and p26 in bone marrow cells from 39 acute leukemia patients were detected by flow cytometry.


RESULTS
The expression ratios of p170 and p26 were 15.89% +/- 4.41% and 17.32% +/- 10.20%, respectively, in previously untreated group, and 31.02% +/- 14.33% and 33.78% +/- 15.97%, respectively, in refractory/relapse group. The difference between the two groups was significant, while there were no correlation between p170 and p26 (r = -0.1578, P > 0.5).


CONCLUSIONS
Both p170 and p26 were related to clinical multidrug resistance, but the mechanisms were different.
Gao
X
X
Institute of Hematology, Shanxi Medical University, Taiyuan.
Zhang
X
X
Qiao
Z
Z
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001324:Autoantigens; D002135:Calcium-Binding Proteins / Q000096:biosynthesis; D002648:Child; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005136:Eye Proteins / Q000096:biosynthesis; D005260:Female; D019254:Genes, bcl-2; D000077614:Golgi Matrix Proteins; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D051603:Recoverin
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001324:Autoantigens; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; C108388:GOLGA3 protein, human; D000077614:Golgi Matrix Proteins; D008565:Membrane Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; C067574:RCV1 protein, Bos taurus; D051603:Recoverin