Preparation and evaluation of samarium (III) phosphate [(153)Sm] colloid (SMPC) for possible therapeutic use.
A simple method of preparation of a new therapeutic colloid, samarium(III) phosphate-(153)Sm (SMPC), is reported involving the reaction of carrier-added (153)SmCl(3) with phosphoric acid. Recovery of the colloid was accomplished by dialysis leading to purification and a radiochemical (RC) yield of more than 90%. The RC purity of purified colloid formulated in isotonic phosphate buffer was more than 99% as assessed by paper chromatography. The product retained its RC purity throughout the period of stability study of 7 days. Complete retention of radioactivity instilled in the rabbit knee joint was observed over the study period of 6 days, with radioactivity in the blood being indistinguishable from the natural background activity. Ninety-six percent of colloidal particles were in the size range of 0.3-2 microm. The promising results demonstrated warrant further studies on SMPC for assessing the suitability for therapy.
Prabhakar
G
G
Radiopharmaceuticals Programme, Board of Radiation and Isotope Technology (BRIT), Bhabha Atomic Research Center (BARC) Vashi Complex, Navi Mumbai, India.
Joshi
S H
SH
Ranganatha
D K
DK
Umamaheswari
S
S
Ananthakrishnan
M
M
Ramamoorthy
N
N
D000818:Animals; D003102:Colloids; D011817:Rabbits; D011868:Radioisotopes / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012493:Samarium / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution
D003102:Colloids; D011868:Radioisotopes; D012493:Samarium