[Prognostic significance of P-glycoprotein expression in acute leukemia in adults].
OBJECTIVE
To explore the prognostic significance of P-glycoprotein (P-gp) expression in previously untreated acute leukemia in adults.


METHODS
P-gp expression in 151 acute myeloblastic leukemia (AML) and 47 acute lymphoblastic leukemia (ALL) was determined by monoclonal antibody UIC2 and flow cytometry.


RESULTS
The rate of complete remission (CR) differed between P-gp+ and P-gp- AML (20.5% vs 78.5%, P < 0.001), but the CR rate did not significantly differ between P-gp+ and P-gp- ALL(66.7% vs 80%, P > 0.05). The six-month relapse rate was significantly higher in P-gp+ group than that of P-gp- group (AML: 66.7% vs 8.7%, P < 0.001; ALL: 50% vs 9.5%, P < 0.05). The median disease-free survival time was shorter in P-gp+ group than in P-gp- group (AML: 5 months vs 13 months; ALL: 4 months vs 13 months).


CONCLUSIONS
Overexpression of P-gp is a poor prognostic factor in adult acute leukemia and P-gp detection is useful for the prediction of treatment response and early relapse.
Jiangsu Institute of Hematology, First Affiliated Hospital, Suzhou Medical College, Suzhou.
J
J
Li
D
D
Hua
X
X
Xia
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000378:metabolism*; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000378:metabolism*; D012008:Recurrence
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1