A new member of the acid-sensing ion channel family.
Acid-sensing ion channels (ASICs) are members of the epithelial sodium channel (ENaC)-degenerin family of two-pass transmembrane segment protein subunits which form multimeric cation channels. Members of the ENaC-degenerin family are gated by stimuli as diverse as protons, peptides and mechanical distension. Here we describe a new member of the family, SPASIC or ASIC 4 (spinal cord ASIC) which is expressed throughout the central nervous system in an overlapping population of neurons that also express the ASIC subunit MDEG2. ASIC-4 which shows 44% identify with ASIC is developmentally regulated and expressed in a subset of sensory neurons as well as in the CNS. However, despite the strong homology with ASIC, the ASIC-4 transcript does not encode a proton gated cation channel.
Department of Biology, University College London, UK.
A N
AN
Akopian
C C
CC
Chen
Y
Y
Ding
P
P
Cesare
J N
JN
Wood
D062565:Acid Sensing Ion Channels; D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002460:Cell Line; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D017124:Conserved Sequence; D062626:Degenerin Sodium Channels; D053503:Epithelial Sodium Channels; D005727:Ganglia, Spinal / Q000378:metabolism; D015723:Gene Library; D007473:Ion Channels / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D018408:Patch-Clamp Techniques; D021122:Protein Subunits; D051381:Rats; D011994:Recombinant Proteins / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015222:Sodium Channels / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D013116:Spinal Cord / Q000378:metabolism; D014158:Transcription, Genetic; D014162:Transfection
C568424:ASIC2 protein, human; C112231:ASIC3 protein, human; D062565:Acid Sensing Ion Channels; C568425:Asic2 protein, rat; D062626:Degenerin Sodium Channels; D053503:Epithelial Sodium Channels; D007473:Ion Channels; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D021122:Protein Subunits; D011994:Recombinant Proteins; D015222:Sodium Channels