[Idiopathic interstitial nephritis induced acute renal failure: clinical and pathological analysis].
OBJECTIVE
To understand idiopathic interstitial nephritis (IIN) and its relationship with acute renal failure as well as its clinical and pathological characteristics for avoiding misdiagnosis and missing diagnosis.


METHODS
A detail clinical and pathological analysis was performed on 7 patients with idiopathic interstitial nephritis.


RESULTS
The major manifestations were acute non-oliguric renal insufficiency combined with mild proteinuria (< 2 g/d), microscopic hematuria and obvious disorder of renal tubular function (for example, glycosuria). Three patients had high gamma-globulinemia and 2 were associated with uveitis. Renal biopsy showed typical tubulointerstial nephritis but glomeruli, and the renal vasculature was almost normal. All patients were treated with prednison. Renal function recovered in 5 patients.


CONCLUSIONS
When a patient has renal insufficiency especially non-oliguric renal failure with disorder of tubular function without definite causes, IIN should be considered. The diagnosis and treatment should be done immediately.
Jin
Q
Q
Department of Nephrology, First Hospital, Beijing Medical University.
Liu
Y
Y
Shen
Y
Y
D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D011241:Prednisone