Electrolyzed strong acid aqueous solution irrigation promotes wound healing in a burn wound model.
The purpose of the study was to understand the effectiveness of electrolyzed strong acid aqueous solution (ESAAS) for acceleration of epithelialization in a rat burn wound model. Eighteen anesthetized Sprague-Dawley rats received 30% total body surface area third-degree burns, and 2 days after injury, the wound eschars were removed. Rats were divided into 3 groups: Group 1, no irrigation; Group 2, irrigation with physiological saline; and Group 3, irrigation with ESAAS. Wounds were observed macroscopically until they were fully epithelialized, and epithelialized wounds were examined microscopically. Epithelialization of the wounds occurred significantly early in the rats treated with ESAAS (p < 0.05). Proliferation of associated lymphocytes and macrophages was more extensive in all rats that underwent irrigation than it was in control rats. ESAAS irrigation may promote tissue growth in burn wounds.
Department of Emergency and Critical Care Medicine, Akita University School of Medicine, Japan.
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Inaba
D000143:Acids / Q000627:therapeutic use*; D000818:Animals; D002056:Burns / Q000473:pathology*; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012996:Solutions; D018709:Statistics, Nonparametric; D007507:Therapeutic Irrigation; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D000143:Acids; D012996:Solutions