Antianaemic properties of ayurvedic drugs, raktavardhak, punarnavasav and navayas louh in albino rats during phenylhydrazine induced haemolytic anaemia.
Single injection of phenylhydrazine[PH] reduced the number of RBC and haemoglobin content; decreased myeloid; erythroid cell ratio in bone marrow and increased Cathepsin D activity in spleen of rats. Ayurvedic drugs raktavardhak, punarnavasav and navayas louh recovered the number of RBC and haemoglobin content and raised myeloid: erythroid cell ratio and normalised cathepsin D activities by counteracting the action phenyl hydrazine. The results confirm the claims of ayurveda that these drugs possess the potency to cure anaemia through protection of RBCs from haemolysis and simultaneously lowering cathepsin D activities from the spleen.
Patil
S
S
Institute of Indian Medicine 36, Kothrud, Pune, India.
Kanase
A
A
Kulkarni
P H
PH
D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002402:Cathepsin D / Q000378:metabolism; D004906:Erythrocyte Count; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D008515:Medicine, Ayurvedic; D010659:Phenylhydrazines / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D006454:Hemoglobins; D010659:Phenylhydrazines; D010936:Plant Extracts; C030299:phenylhydrazine; D002402:Cathepsin D