New macrolactins from a marine Bacillus sp. Sc026.
Bioassay-guided fractionation of the EtOAc extract of a marine Bacillus sp. Sc026 culture broth has led to the isolation of the known compound, macrolactin F (1), together with two new compounds, 7-O-succinyl macrolactin F (2) and 7-O-succinyl macrolactin A (3). The chemical structures of 1-3 were elucidated on the basis of spectral data analyses and literature data comparison. Compounds 1-3 exhibited antibacterial activity against Bacillus subtilis and Staphylococcus aureus.
Departments of Pharmacognosy and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
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Jaruchoktaweechai
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Suwanborirux
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Tanasupawatt
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Kittakoop
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Menasveta
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry* / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007783:Lactones