Primary T-cell-rich B-cell lymphoma of the ethmoid sinus. A case report with 5 years of follow-up.
T-cell-rich B-cell lymphoma (TCRBCL) is an uncommon and recently recognized variant of B-cell non-Hodgkin lymphoma characterized by a few large neoplastic B cells amid a predominant population of reactive T lymphocytes and variable numbers of histiocytes. Morphologically, TCRBCL resembles a variety of non-Hodgkin lymphomas and Hodgkin disease. Accurate diagnosis and proper treatment are essential to assure a favorable prognosis. To our knowledge, this is the first report of ethmoid sinus presentation of TCRBCL in an Epstein-Barr virus-negative 51-year-old man. Combined chemotherapy and radiotherapy were administered based on the correct diagnosis. The patient has had a complete response with no recurrence during the 5-year follow-up.
Department of Pathology, Harbor-UCLA Medical Center, University of California Los Angeles, School of Medicine, and the Harbor-UCLA Research and Education Institute, USA.
J
J
Wang
N C
NC
Sun
S M
SM
Weinstein
R
R
Canalis
D015703:Antigens, CD / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001706:Biopsy; D003131:Combined Modality Therapy; D005005:Ethmoid Sinus / Q000000981:diagnostic imaging / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D013601:T-Lymphocytes / Q000473:pathology*; D014057:Tomography, X-Ray Computed
D015703:Antigens, CD; D014408:Biomarkers, Tumor