Severe Chlamydia pneumoniae infection in patients with neutropenia: case reports and literature review.
Three cases of life-threatening C. pneumoniae infection in patients with acute leukemia and treatment-induced neutropenia are described. Diagnosis was made on the basis of the detection of C. pneumoniae-DNA, complemented by serology. The role of the widely distributed respiratory tract pathogen C. pneumoniae in febrile neutropenia is poorly understood, and studies are needed to estimate the frequency of severe pulmonary infection caused by this agent in patients with neutropenia.
Departments of Medical Microbiology and Hygiene and Hematology and Oncology, University Hospital Ulm, Ulm, Germany.
M
M
Heinemann
W V
WV
Kern
D
D
Bunjes
R
R
Marre
A
A
Essig
D000293:Adolescent; D002690:Chlamydia Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology / Q000628:therapy; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications* / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000276:immunology