[Long-term results of intravesical N-CWS instillation to prevent recurrence after surgery for bladder cancer].
OBJECTIVE
To evaluate the long term results of intravesical nocardia rubre cell wall skeleton instillation to prevent recurrence after surgery for bladder cancer.


METHODS
A randomized and placedo-controlled trial on intravesical N-CWS instillation versus mitomycin-C(MMC) therapy for recurrence prevention in postopenative bladder cancer patients was carried out.


RESULTS
Fourty-five patients were treated with N-CWS with 39 followed for 12 to 60 months. Thirteen patients developed recurrence. The 1-year tumor free survival rate was 87.2% and that at 5 years was 66.7%. Thirty patients as treated with MMC serving as controll with 25 followed for the same duration, twelve patients developed recurrence. The 1-year tumor free survival rate was 84% and that at 5 years was 52%. The results indicate that N-CWS gave better results with rare and milder side effects.


CONCLUSIONS
N-CWS is believed to be one of the effective drugs in preventing bladder cancer recurrence after surgery.
Department of Urology, Union Hospital, Fujian Medical College, Fuzhou.
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S
Chen
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Lin
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Xu
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002295:Carcinoma, Transitional Cell / Q000601:surgery / Q000628:therapy*; D017358:Cell Wall Skeleton / Q000627:therapeutic use*; D015653:Cystectomy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009615:Nocardia; D011184:Postoperative Period; D015996:Survival Rate; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000601:surgery / Q000628:therapy*
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D017358:Cell Wall Skeleton; C044553:cell wall skeleton, Nocardia; D016685:Mitomycin