Spontaneous cerebral haemorrhage without hypertension in non-mosaic 45X Turner's syndrome.
Cerebral haemorrhage without hypertension, arteriosclerosis or clotting defect has not been reported in patients with Turner's syndrome before. In a 51 year old female patient with non-mosaic Turner's syndrome, acute aphasia and right-sided hemiplegia occurred, due to left-sided basal ganglia haemorrhage. The history for hypertension was negative, blood pressure was normal throughout hospitalisation as well as during 24 h monitoring, and all tests for secondary hypertension were negative. There was no indication of arteriosclerosis or a clotting defect. Since there were hypermobile joints, hyperextensible skin and ectatic ascending aorta and brachiocephalic trunk on angiography, a general connective tissue defect was assumed, making arteries more vulnerable to physiologically increased blood pressure and rupture of intracerebral arteries with consecutive bleeding.
Finsterer
J
J
Neurological Department, Neurological Hospital Rosenhügel, Vienna, Austria. fj@2nr.nkr.magwien.gv.at
Zartl
M
M
Samec
P
P
D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D002536:Cerebral Arteries / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009030:Mosaicism / Q000473:pathology*; D011859:Radiography; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology; D014652:Vascular Diseases / Q000150:complications / Q000209:etiology / Q000473:pathology