Prolactin and polyamine catabolism: specific effect on polyamine oxidase activity in rat thymus.
Much evidence suggests that prolactin has an immunoregulatory function and that its effects on cells of the immune system depend on the level and specific forms of the receptors present on the target cells. The effect of administration of prolactin on polyamine catabolism was investigated in thymus of male intact rats by measuring the activities of spermidine/spermine N(1)-acetyltransferase and polyamine oxidase, because of the relationships between polyamines (especially putrescine) and the immune system. The administration of prolactin to rats resulted in the rapid induction of spermidine/spermine N(1)-acetyltransferase activity in the thymus (1.6-times the level of control rats, within 4 h), and in a marked decrease in polyamine oxidase activity at 24 h. The changes in enzyme activities were accompanied by an increase in putrescine concentration and a decrease in spermidine and spermine concentrations. In the spleen, prolactin increased SAT activity only 24 h after administration and was ineffective on PAO activity.
Centro di Studio sulla Patologia Cellulare, C.N.R, c/o Istituto di Patologia Generale, Università di Milano, Via Mangiagalli 31, 20133, Milan, Italy. mariaelena.ferioli@unimi.it
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D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D008297:Male; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism*; D011388:Prolactin / Q000494:pharmacology*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism; D013154:Spleen / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D000097667:Polyamine Oxidase; D000099228:Diamine N-Acetyltransferase
D000123:Acetyltransferases; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011073:Polyamines; D011388:Prolactin; D011700:Putrescine; D013095:Spermidine; D013096:Spermine; D000097667:Polyamine Oxidase; D000099228:Diamine N-Acetyltransferase