GABA modulation of cocaine self-administration.
Recent experiments suggest that GABA compounds produce a clinically relevant modulation of cocaine reinforcement. This review summarizes the results of a number of studies that examined the effect of the GABAB agonist baclofen on cocaine self-administration using a variety of schedules of reinforcement. The results demonstrate that baclofen causes a dramatic reduction in cocaine self-administration which does not appear to be accounted for by a general disruption of behavior. However, the effect is dependent on the unit injection dose of cocaine and on the response requirements of the schedule. These results predict that in a clinical setting any potential therapeutic effect of baclofen will interact with the cost and availability of cocaine.
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1083, USA. dcsrobts@wfubmc.edu
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D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D003042:Cocaine / Q000008:administration & dosage*; D003213:Conditioning, Psychological / Q000187:drug effects; D063065:Organophosphonates / Q000494:pharmacology*; D010721:Phosphinic Acids; D012054:Reinforcement, Psychology; D012646:Self Administration; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
C112036:3-amino-2-(S)-hydroxypropyl-methyl-phosphinic acid; D063065:Organophosphonates; D010721:Phosphinic Acids; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; D003042:Cocaine