Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage.
This study examines the anti-ulcerogenic activity of eugenol, a natural compound obtained from many natural sources. Gastric ulcers, induced by administration of two ulcerogenic agents, i.e. platelet activating factor (PAF) and ethanol, were dose-dependently and significantly reduced by eugenol (10-100 mg/kg, p.o.) pre-treatment. Eugenol was able to reduce not only the number of ulcers but also the gravity of lesions.
Capasso
R
R
Department of Pharmaceutical Sciences, Via Ponte Don Melillo, 84084, Fisciano, Salerno, Italy.
Pinto
L
L
Vuotto
M L
ML
Di Carlo
G
G
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005054:Eugenol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D026323:Myristica; D008517:Phytotherapy; D010972:Platelet Activating Factor / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D010972:Platelet Activating Factor; D000431:Ethanol; D005054:Eugenol