In vivo evaluation of carborane gadolinium-DTPA complex as an MR imaging boron carrier.
The evaluation of the Gd-carborane complex 2 as an MR imaging and boron carrier agent was carried out in vivo using tumor-bearing Donryu rats, MRI, ICP-AES, and alpha-autoradiography. The MR imaging revealed that the carborane Gd-DTPA 2 was metabolized slower in the body than Gd-DTPA 1. The results of the ICP-AES method indicated that compound 2 was incorporated into normal tissues and metabolized quickly, whereas it was not accumulated into tumor or brain tissue. The alpha-autoradiography showed that a high level of boron was obtained in the internal organs and in the necrosis of tumor tissue.
Nakamura
H
H
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai, Japan.
Fukuda
H
H
Girald
F
F
Kobayashi
T
T
Hiratsuka
J
J
Akaizawa
T
T
Nemoto
H
H
Cai
J
J
Yoshida
K
K
Yamamoto
Y
Y
D000818:Animals; D001345:Autoradiography; D001895:Boron / Q000378:metabolism; D003287:Contrast Media; D019786:Gadolinium DTPA / Q000737:chemistry* / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging; D008297:Male; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000378:metabolism; D011859:Radiography; D051381:Rats; D014018:Tissue Distribution
D003287:Contrast Media; D019786:Gadolinium DTPA; D001895:Boron