Photosensitization of red blood cell hemolysis by lutetium texaphyrin.
Lutetium (III) texaphyrin photosensitizes postirradiation or "delayed" photohemolysis (DPH) of human and bovine red blood cells at 730 nm by a Type-2 pathway mediated by singlet molecular oxygen. The DPH rate increases with increasing incubation temperature and with the second power of the incident fluence. The experimental DPH curves are in good agreement with a multi-hit kinetics model based on target theory.
Wenske Laser Center, Ravenswood Hospital Medical Center, Chicago, IL, USA.
M D
MD
Bilgin
M A
MA
al Akhras
M
M
Khalili
H
H
Hemmati
L I
LI
Grossweiner
D000818:Animals; D002417:Cattle; D004912:Erythrocytes / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008665:Metalloporphyrins / Q000493:pharmacokinetics / Q000494:pharmacology*; D008954:Models, Biological; D017319:Photosensitizing Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D013696:Temperature
D008665:Metalloporphyrins; D017319:Photosensitizing Agents; C102825:motexafin lutetium; C437683:motexafin gadolinium