Expanded scope in ethylene-alkyne cross-metathesis: coordinating heteroatom functionality at the propargylic position.
The Grubbs 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene-substituted ruthenium complex 1 catalyzed ethylene-alkyne cross-metathesis and was shown to tolerate free hydroxyl groups and coordinating functionality at the propargylic and homopropargylic positions. Hindered and enantiomerically enriched 1-substituted alkynes also react efficiently under the reported conditions.
Department of Chemistry, State University of New York, Buffalo, New York 14260-3000, USA.
J A
JA
Smulik
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Diver
D000480:Alkynes / Q000737:chemistry* / Q000378:metabolism; D002384:Catalysis; D002614:Chelating Agents / Q000378:metabolism; D005030:Ethylenes / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000378:metabolism*; D013237:Stereoisomerism
D000480:Alkynes; D002614:Chelating Agents; D005030:Ethylenes; D017975:Ruthenium Compounds