Synergistic effect between iron and gadolinium in MRI.
Different combinations of iron glycerophosphate (Fe) and gadolinium-diethylene triamine pentaacetic acid (DTPA) (Gd) were imaged with a three-dimensional (3D) gradient-recalled echo (GRE), a 2D GRE, and a HASTE sequence on a 1.5-T MR scanner. A combination of Fe and Gd results in a synergistic effect, which improves the signal gain for selective 3D imaging of the colon and simultaneously decreases the endoluminal signal on the HASTE and 2D GRE images for better visualization of water and Gd-enhanced structures in the gut wall.
Department of Radiology, University Hospital Tuebingen, Germany. wolfgang.luboldt@med.uni-tuebingen.de
W
W
Luboldt
D
D
Kienzler
M
M
Seemann
D
D
Friess
F
F
Schick
M
M
Laniado
J F
JF
Schaefer
C D
CD
Claussen
D003108:Colonic Diseases / Q000175:diagnosis; D003287:Contrast Media / Q000737:chemistry*; D004357:Drug Synergism; D019786:Gadolinium DTPA / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry*
D003287:Contrast Media; D009942:Organometallic Compounds; C413563:iron glycerophosphate; D019786:Gadolinium DTPA