The rat vertex-middle latency auditory-evoked potential as indicator of anaesthetic depth: a comparison with evoked-reflex testing.
We investigated whether components from the rat Vx-MLAEP could be used to assess depth of anaesthesia induced by propofol. Propofol decreased MLAEP amplitudes and increased latencies. We propose that the P(16)-N(22) wave in the rat MLAEP is similar to the human P1, and that recovery of this wave during propofol anaesthesia correlates with behavioural measures of the regaining of consciousness.
Haberham
Z L
ZL
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, NL-3508 TD, Utrecht, The Netherlands. z.l.haberham@las.vet.uu.nl
van den Brom
W E
WE
Venker-van Haagen
A J
AJ
de Groot
H N
HN
Baumans
V
V
Hellebrekers
L J
LJ
D000758:Anesthesia / Q000379:methods*; D000818:Animals; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D008297:Male; D015742:Propofol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects* / Q000502:physiology
D015742:Propofol