Accelerated fluid bed drying using NIR monitoring and phenomenological modeling.
A "fast-drying" method to accelerate the fluid bed drying process is presented. It relies on concepts of heat and mass transfer with real-time near-infrared (NIR) monitoring of moisture. Triplicate trials show that fast drying can reduce granulation drying time by half over single-temperature cycles. The product is equivalent in every way tested to material made using a conventional cycle even though the inlet temperature throughout the constant-rate stage was higher than the melting point of the compound. Tablets made from the fast-dried granulation exhibit equivalent physical characteristics to tablets made from granulations dried at a single, lower temperature.
Morris
K R
KR
Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1336, USA.
Stowell
J G
JG
Byrn
S R
SR
Placette
A W
AW
Davis
T D
TD
Peck
G E
GE
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003890:Desiccation; D007052:Ibuprofen / Q000737:chemistry; D007700:Kinetics; D010316:Particle Size; D019265:Spectroscopy, Near-Infrared; D013607:Tablets; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013607:Tablets; D014867:Water; D007052:Ibuprofen