Potential applications of carbomer in oral mucoadhesive controlled drug delivery system: a review.
Carbomers are extensively being used in controlled drug delivery systems (CDDS). They are also finding numerous applications in oral mucoadhesive drug delivery because of their ability to interact with the mucus glycoprotein and to remain localized to a specific site. The present review aims at giving an insight into the potential application of carbomers in mucoadhesive CDDS. This review deals with the physicochemical properties of carbomers and various mechanisms of mucoadhesion. The mechanism for the release of the drug, both water soluble and water insoluble, is discussed. The use of carbomers in oral delivery of peptides or protein-based drugs is also covered.
Singla
A K
AK
Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Chawla
M
M
Singh
A
A
D000180:Acrylic Resins / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D000269:Adhesives / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D000278:Administration, Buccal; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems
D000180:Acrylic Resins; D000269:Adhesives; D003692:Delayed-Action Preparations; C006903:carbopol 940