["Mode for mutation" in the natural population of Drosophila melanogaster from Umani is caused by distribution of a hobo-induced inversion in the regulatory region of the yellow gene].
A mutation outburst of the yellow gene occurred in a Drosophila melanogaster population from the town of Uman' from 1982 to 1991 and was associated with the instability of several alleles. Molecular genetic analysis revealed a deletion variant of the hobo transposable element in the same site of the regulatory region of yellow in the mutant alleles and their derivatives. The outburst of the yellow-2 mutations was attributed to the spreading of the X chromosome, which contained an inversion of the yellow regulatory region, through the population. Reinversion resulted in the wild-type phenotype. Crossing lines carrying the inversion with laboratory line C(1)DX, ywf induced instability of the yellow alleles, which was associated with duplication or multiplication of a fragment of the yellow gene. Most derivative lines eventually became stable. The loss of instability was not associated with phenotypic changes; molecular genetic changes included a loss of the duplicated sequences or a deletion of the inverted regulatory region of the yellow gene.
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia. zakharlp@bionet.nsc.ru
L P
LP
Zakharenko
I K
IK
Zakharov
O A
OA
Romanova
M A
MA
Voloshina
E M
EM
Gracheva
E Z
EZ
Kochieva
M D
MD
Golubovskiĭ
P G
PG
Georgiev
D000818:Animals; D001483:Base Sequence; D007446:Chromosome Inversion; D003433:Crosses, Genetic; D017931:DNA Primers; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics*; D019476:Insect Proteins / Q000235:genetics*; D009154:Mutation; D012045:Regulatory Sequences, Nucleic Acid
D017931:DNA Primers; D029721:Drosophila Proteins; D019476:Insect Proteins; C050680:y protein, Drosophila