Immunotherapy of hematologic malignancies and metastatic solid tumors in experimental animals and man.
Following engraftment of donor hematopoietic cells and induction of host-versus-graft tolerance, immunocompetent lymphocytes of donor origin can induce graft-versus-leukemia (GVL) and graft-versus-tumor (GVT) effects. Engraftment of allogeneic bone marrow cells can be accomplished following non-myeloablative conditioning while possibly controlling graft-versus-host disease (GVHD). GVL and GVT effects may thus be successfully accomplished following non-myeloablative stem cell transplantation (NST) as shown by data derived from experimental animals and man.
Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah University Hospital, Jerusalem, Israel.
S
S
Slavin
R
R
Or
T
T
Prighozina
O
O
Gurevitch
M
M
Aker
S
S
Panighari
M
M
Shapira
A
A
Nagler
D000818:Animals; D016026:Bone Marrow Transplantation; D020544:Graft vs Leukemia Effect; D020350:Graft vs Tumor Effect; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007167:Immunotherapy; D007938:Leukemia / Q000628:therapy*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000628:therapy*; D014184:Transplantation, Homologous