Evidence for elevated telomerase activity in small cell carcinoma of the bladder.
Telomerase activity was found to be elevated using a quantitative assay on snap-frozen protein extracts of exfoliated cells in urine and bladder washings and tumor tissue obtained from a male patient with small cell carcinoma of the bladder. To the best of our knowledge, this is the first demonstration of elevated values of telomerase activity in genitourinary small cell carcinoma and is in keeping with the findings in primary lung locations.
Department of Urology, University of Udine, Udine, Italy.
C
C
Selli
S
S
Gelmini
C A
CA
Scott
A
A
Crisci
G
G
Giannarini
C
C
Orlando
D000368:Aged; D015415:Biomarkers; D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000201:enzymology* / Q000652:urine; D002295:Carcinoma, Transitional Cell / Q000201:enzymology / Q000652:urine; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology; D008297:Male; D016133:Polymerase Chain Reaction; D019098:Telomerase / Q000032:analysis* / Q000378:metabolism / Q000652:urine; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000201:enzymology* / Q000652:urine
D015415:Biomarkers; D019098:Telomerase