Lactoferrin and eosinophilic cationic protein in nasal secretions of patients with experimental rhinovirus colds, natural colds, and presumed acute community-acquired bacterial sinusitis.
To distinguish sinusitis from uncomplicated "colds," we examined lactoferrin and eosinophilic cationic protein (ECP) in nasal secretions. Lactoferrin titers were >/=1:400 in 4% of persons with uncomplicated colds and controls but in 79% of persons with sinusitis or purulent sputa. ECP levels were >200 ng/ml in 61% of persons with colds and >3,000 ng/ml in 62% of persons with sinusitis. Nasal lactoferrin helps distinguish sinusitis from colds.
Niehaus
M D
MD
Divisions of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Gwaltney
J M
JM
Hendley
J O
JO
Newman
M J
MJ
Heymann
P W
PW
Rakes
G P
GP
Platts-Mills
T A
TA
Guerrant
R L
RL
D001424:Bacterial Infections / Q000175:diagnosis / Q000378:metabolism; D001798:Blood Proteins / Q000032:analysis*; D003139:Common Cold / Q000175:diagnosis* / Q000378:metabolism / Q000821:virology; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000378:metabolism; D047091:Eosinophil Granule Proteins; D006801:Humans; D007781:Lactoferrin / Q000032:analysis*; D009093:Mucus / Q000737:chemistry*; D009297:Nasal Mucosa / Q000378:metabolism; D012229:Rhinovirus; D012260:Ribonucleases; D012852:Sinusitis / Q000175:diagnosis* / Q000378:metabolism
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases; D007781:Lactoferrin