Evaluation of persistence of ductus venosus with tc-99m DTPA galactosyl human serum albumin liver scintigraphy and I-123 iodoamphetamine per-rectal portal scintigraphy.
Tc-99m DTPA galactosyl human serum albumin (Tc-99m GSA) hepatic scintigraphy was performed in two patients with patent ductus venosus before and after operation. To evaluate the portosystemic shunt flow, per-rectal portal scintigraphy with I-123 N-isopropyl-p-iodoamphetamine (IMP) was undergone in the same period. The portosystemic shunt indices (PSS index) were decreased from 67.9% to 7.3% in the patient 1, and from 77.3% to 22.7% in the patient 2, respectively. Quantitative indices of Tc-99m GSA hepatic scintigraphy improved dramatically in both patients. Under microscopic examination, nearly all the hepatic cells showed signs of severe fatty degeneration. After the operation, the severe fatty degeneration was alleviated and all the hepatic cells appeared normal. I-123 IMP per-rectal portal scintigraphy and Tc-99m GSA hepatic scintigraphy were useful in evaluating the quantitative shunt flow of the persistent ductus venosus and its hepatic functional reserve.
Department of Radiology, Kumamoto University School of Medicine Japan.
T
T
Kira
S
S
Ikeda
Y
Y
Sera
S
S
Tomiguchi
M
M
Takahashi
T
T
Uchino
F
F
Endo
D000662:Amphetamines / Q000493:pharmacokinetics; D002675:Child, Preschool; D015902:Gamma Cameras; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D008099:Liver / Q000000981:diagnostic imaging*; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D009679:Nuclear Family; D011169:Portal Vein / Q000002:abnormalities* / Q000601:surgery; D011170:Portasystemic Shunt, Surgical; D011877:Radionuclide Imaging / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013668:Technetium Tc 99m Aggregated Albumin / Q000493:pharmacokinetics; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics; D014471:Umbilical Veins / Q000002:abnormalities* / Q000601:surgery; D014682:Vena Cava, Inferior / Q000002:abnormalities* / Q000601:surgery
D000662:Amphetamines; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; C041336:4-iodoamphetamine; D016284:Technetium Tc 99m Pentetate