Chronic low-dose cocaine treatment during adolescence facilitates aggression in hamsters.
Cocaine abuse during adolescence represents a significant health risk because of the potential for both acute and long-term negative physical and psychological sequelae, including increased aggressive behavior. This study examined the effects of chronic adolescent cocaine exposure on aggression in an animal model. It was hypothesized that chronic cocaine exposure during adolescence predisposes animals to heightened levels of aggressive behavior. To test this hypothesis, adolescent male golden hamsters (Mesocricetus auratus) were administered cocaine hydrochloride during their entire adolescent development (Postnatal Days 27-54) and then tested for offensive aggression using the resident-intruder model. Animals treated with low-dose cocaine during adolescence showed significantly elevated measures of offensive aggression (i.e., increased number of bites, attacks, and decreased latencies to bite), whereas measures of social communication, sexual motivation and motor activity remained constant. Cocaine-treated animals did not differ in body weight gain from controls, suggesting no dramatic physiological effects of adolescent cocaine exposure on body growth at the doses tested.
Department of Psychiatry, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA.
R J
RJ
Harrison
D F
DF
Connor
C
C
Nowak
R H
RH
Melloni
D000367:Age Factors; D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects
D003042:Cocaine