A possible association between exposure to n-hexane and parkinsonism.
Recently, some case-control studies and case reports have shown an association between solvent exposure and parkinsonisms. We present a 55-year-old male parkinsonian patient with chronic exposure to n-hexane for 17 years. The results of neurophysiological (electromyography, evoked potentials), neuroradiological (MRI) and neuropsychological tests performed on the patient suggest a role of this solvent at the level of the central nervous system. Biological susceptibility to neurotoxic compounds is discussed briefly.
Department of Neurosciences, La Sapienza University, Roma, Italy.
N
N
Vanacore
M
M
Gasparini
L
L
Brusa
G
G
Meco
D000978:Antiparkinson Agents / Q000627:therapeutic use; D002230:Carbidopa / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004576:Electromyography; D016057:Evoked Potentials, Auditory, Brain Stem; D005073:Evoked Potentials, Somatosensory; D006586:Hexanes / Q000009:adverse effects*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009784:Occupational Diseases / Q000139:chemically induced; D020734:Parkinsonian Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D012642:Selegiline / Q000627:therapeutic use; D012997:Solvents / Q000009:adverse effects*
D000978:Antiparkinson Agents; D006586:Hexanes; D012997:Solvents; C026385:n-hexane; D012642:Selegiline; D007980:Levodopa; D002230:Carbidopa