Treatment of bipolar I disorder in an adolescent with olanzapine.
Bipolar I disorder is estimated to affect 0.6% of adolescents. Lithium, sodium valproate, carbamazapine, and adjunctive treatment with benzodiazapines and antipsychotics have been used to treat bipolar I disorders. We report a case of a 17-year-old adolescent male with bipolar I disorder who responded favorably to the treatment with the atypical antipsychotic olanzapine. We hypothesize that olanzapine's broad affinity for both dopaminergic and serotonergic receptors may be related to the beneficial therapeutic outcome.
Department of Psychiatry, VAMC, Manchester, New Hampshire 03104-4098, USA. Khouzam.Hani@Manchester.VA.Gov
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El-Gabalawi
D000293:Adolescent; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales
D018692:Antimanic Agents; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine