Lipid metabolism as a target for potassium channel effectors.
K(+) channel effectors are widely used in the treatment of various diseases, including diabetes mellitus type II, hypertension, and cardiac arrhythmia. In addition, a constantly growing body of literature reveals that some of these substances, despite their direct effect on K(+) channels, may influence cellular lipid metabolism. As a result, membrane lipid content and cellular concentrations of lipid messengers are changed. Due to the dependence of K(+) channel activity on membrane lipids, these observations seem to be of particular importance not only to characterize secondary effects of K(+) channel effectors but also to understand the long-term effects of these agents on K(+) channel activity.
Laboratories of *Intracellular Ion Channels, Nencki Institute of Experimental Biology, Warsaw, Poland. slawek@nencki.gov.pl
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Pikula
D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D050356:Lipid Metabolism; D010718:Phosphatidylserines / Q000096:biosynthesis; D010741:Phospholipases A / Q000378:metabolism; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000819:agonists / Q000378:metabolism*; D013453:Sulfonylurea Compounds / Q000494:pharmacology*; D010738:Type C Phospholipases / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D007004:Hypoglycemic Agents; D010718:Phosphatidylserines; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D013453:Sulfonylurea Compounds; D010741:Phospholipases A; D010738:Type C Phospholipases