Protective effect of isoflavone derivative against photocarcinogenesis in a mouse model.
Plant-derived isoflavones are currently receiving much attention because of their phyto-estrogenic and antioxidant activities. In this study, we describe novel photoprotective effects of one isoflavone derivative from red clover (NV07), following its application topically in Skh:HR-1 hairless mice. We found that in mice irradiated in the short-term (3 days) with minimally erythemal solar simulated UV radiation, topical lotions containing NV07 dose-responsively reduced the erythema-associated oedema, the induction of ornithine decarboxylase, and the suppression of contact hypersensitivity. In mice irradiated chronically (50 days), daily application of topical NV07-lotion reduced photocarcinogenesis significantly, and appeared to be actively protective during both the initiation phase and the later promotion phase of tumour induction.
Widyarini
S
S
Department of Veterinary Anatomy and Pathology, University of Sydney, New South Wales, Australia.
Spinks
N
N
Reeve
V E
VE
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000209:etiology; D007887:Fabaceae; D005260:Female; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control*; D009824:Ointments; D009955:Ornithine Decarboxylase / Q000378:metabolism; D010946:Plants, Medicinal; D012867:Skin / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control*; D014466:Ultraviolet Rays
D016588:Anticarcinogenic Agents; D007529:Isoflavones; D009824:Ointments; D009955:Ornithine Decarboxylase