[The characteristics of the development of immunity with a primary immunization complex using adsorbed DTP vaccine].
The intensity of immunity, depending on immune response variants characterized by the definite composition of the T and B lymphocyte subpopulation in peripheral blood, was studied in 70 practically healthy young children after the primary complex of immunization with adsorbed DPT vaccine. The most stable immune reaction was shown to appear in children with the hyperergic and normoergic variants of immune response to diphtheria and tetanus toxoids, while the reaction to pertussis antigen was essentially weaker both after the second vaccination and after the first revaccination. In children with the hypoergic variant of immune response to all components of adsorbed DPT vaccine the resulting immune reaction was 2.5-3 times weaker than in children of other groups.
Kosenkova
T V
TV
Medical Academy, Smolensk, Russia.
Fedorov
G N
GN
Naperstnikov
V V
VV
Grigor'eva
V N
VN
Koliasnikova
I V
IV
Stefani
D V
DV
D000327:Adsorption; D000907:Antibodies, Bacterial / Q000097:blood; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007115:Immunization Schedule; D007117:Immunization, Secondary / Q000706:statistics & numerical data; D007223:Infant; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000276:immunology
D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine