Surface plasmon resonance analysis of dynamic biological interactions with biomaterials.
Surface plasmon resonance (SPR) is an optical technique that is widely gaining recognition as a valuable tool to investigate biological interactions. SPR offers real time in situ analysis of dynamic surface events and, thus, is capable of defining rates of adsorption and desorption for a range of surface interactions. In this review we highlight the diversity of SPR analysis. Examples of a wide range of applications of SPR are presented, concentrating on work relevant to the analysis of biomaterials. Particular emphasis is given to the use of SPR as a complimentary tool, showing the broad range of techniques that are routinely used alongside SPR analysis.
Laboratory of Biophysics and Surface Analysis, School of Pharmaceutical Sciences, The University of Nottingham, University Park, UK. r.green@surrey.ac.uk
R J
RJ
Green
R A
RA
Frazier
K M
KM
Shakesheff
M C
MC
Davies
C J
CJ
Roberts
S J
SJ
Tendler
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics; D001698:Biomedical Engineering; D004247:DNA / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D011506:Proteins / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000379:methods*; D013499:Surface Properties; D018406:Virus Physiological Phenomena
D001672:Biocompatible Materials; D011506:Proteins; D004247:DNA