Effects of the transdermal nicotine patch on normalization of HDL-C and its subfractions.
BACKGROUND
Smoking reduces HDL-C and its subfractions, and smoking cessation leads to normalization of these lipoproteins. Nicotine replacement therapy is an important weapon employed by those attempting to quit smoking. This study examined the effects of the transdermal nicotine patch ("patch") on lipoproteins.


METHODS
Ten male and 17 female smokers refrained from smoking for 77 days. The patch was utilized during the first 35 days and then removed for the remaining 42 days. Seven male and 9 female nonsmokers were controls.


RESULTS
HDL-C, HDL(2)-C, and HDL(3)-C levels were significantly lower in smokers when compared with controls. These differences were sustained during the initial 35 days when using the patch. Over the following 42 days, however, these lipoproteins normalized to values similar to those of control subjects. Females who quit smoking gained 2.1 kg after the patch was removed.


CONCLUSIONS
It was concluded that nicotine as administered by the transdermal nicotine patch inhibits normalization of HDL-C, HDL(2)-C, and HDL(3)-C in those who have quit smoking. Removal of the patch results in normalization of these lipoproteins. The patch appeared to prevent weight gain among female subjects.
Moffatt
R J
RJ
Department of Nutrition, Food, and Exercise Sciences, Florida State University, Tallahassee, Florida 32306-1493, USA. rmoffatt@mailer.fsu.edu
Biggerstaff
K D
KD
Stamford
B A
BA
D000279:Administration, Cutaneous; D000328:Adult; D001835:Body Weight / Q000187:drug effects; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood* / Q000737:chemistry / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000627:therapeutic use*; D018722:Nicotinic Agonists / Q000627:therapeutic use*; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D015430:Weight Gain / Q000187:drug effects
D008076:Cholesterol, HDL; D018722:Nicotinic Agonists; D009538:Nicotine