[An allergen from Blattella germanica cockroaches and its immunological properties].
The optimum method for obtaining allergenic preparation with high specific activity and stable physico-chemical characteristics from cockroaches of the species B. germanica was developed. The quantitative content of cockroach allergens Bla g1 and Bla g2 was determined in experimental batches. The age structure of sensitization to cockroaches in 124 bronchial asthma patients (50 adults and 74 children) was studied. Specific IgE antibodies to B. germanica were detected in 34% of the examined adults and 63.5% of the children.
Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
S N
SN
Zhirova
V B
VB
Gervazieva
D000328:Adult; D000485:Allergens / Q000032:analysis / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D000818:Animals; D000906:Antibodies / Q000097:blood; D052179:Antigens, Plant; D016282:Aspartic Acid Endopeptidases / Q000032:analysis / Q000737:chemistry / Q000276:immunology* / Q000302:isolation & purification; D001249:Asthma / Q000276:immunology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002648:Child; D003058:Cockroaches / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D000939:Epitopes / Q000032:analysis / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D012882:Skin Tests
D000485:Allergens; D000906:Antibodies; D052179:Antigens, Plant; D000939:Epitopes; C105482:allergen Bla g 1; D007073:Immunoglobulin E; D016282:Aspartic Acid Endopeptidases; C094699:allergen Bla g 2