Recurrence of ibuprofen-induced aseptic meningitis in an otherwise healthy patient.
We report the case of a 74-year-old woman who had three episodes of aseptic meningitis in a period of 20 years. These episodes always occurred a few hours after the assumption of a non-steroidal anti-inflammatory drug (NSAID) per os. Nevertheless, the pharmacological anamnesis did not receive proper attention, neither the first nor the second time, and the meningeal syndrome with aseptic liquor was attributed to a viral aggression. However, when the third episode occurred, due to the strict time correlation between the assumption of the drug and the occurrence of symptoms, both the results of the liquoral analysis and the anamnestic records allowed recognition of ibuprofen as the cause of acute meningitis.
Pisani
E
E
Division of Neurology, Hospital of Mirano, Italy.
Fattorello
C
C
Leotta
M R
MR
Marcello
O
O
Zuliani
C
C
D000368:Aged; D000374:Aggression / Q000187:drug effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002555:Cerebrospinal Fluid / Q000166:cytology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D007964:Leukocytosis / Q000139:chemically induced; D008214:Lymphocytes; D008487:Medical History Taking; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000175:diagnosis; D008587:Meningitis, Viral / Q000175:diagnosis*; D009504:Neutrophils; D010146:Pain / Q000188:drug therapy; D012008:Recurrence; D014839:Vomiting / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen