Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to L-thyronine.
The synthesis of substituted phenoxyphenyl oxamic acid derivatives related to L-thyronine (L-T3) is described. The in vitro and in vivo cholesterol lowering and cardiovascular effects of these compounds are presented and discussed.
Stanton
J L
JL
Metabolic and Cardiovascular Diseases Research, Novartis Institute for Biomedical Research, Summit, NJ 07901, USA. james.stanton@pharma.novartis.com
Cahill
E
E
Dotson
R
R
Tan
J
J
Tomaselli
H C
HC
Wasvary
J M
JM
Stephan
Z F
ZF
Steele
R E
RE
D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D010072:Oxamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013970:Thyronines / Q000737:chemistry*
D000924:Anticholesteremic Agents; D002317:Cardiovascular Agents; D013970:Thyronines; D010072:Oxamic Acid