Studies on the novel anti-staphyloccal compound nematophin.
A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active.
Medicines Research Centre, Glaxo Wellcome SpA, Verona, Italy. gk27184@glaxowellcome.co.uk
G
G
Kennedy
M
M
Viziano
J A
JA
Winders
P
P
Cavallini
M
M
Gevi
F
F
Micheli
P
P
Rodegher
P
P
Seneci
A
A
Zumerle
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007211:Indoles; C109330:nematophin