[Decreasing prevalence of Helicobacter pylori: a consequence of treatment of gastroduodenal ulcers].
Four patients with gastroduodenal ulcers in the absence of Helicobacter pylori illustrate the decreasing prevalence of this microorganism. One was a 19-year-old boy with nausea, diarrhoea and weight loss caused by multiple gastroduodenal ulcers due to the Zollinger-Ellison syndrome. Another was a 36-year-old man with abdominal discomfort caused by an ulcer due to Crohn's disease. The other two cases concerned a 29-year-old man and a 68-year-old woman with relapsing ulcer disease and active bleeding, in whom no causal factors could be determined. Recent studies suggest a decreasing prevalence of H. pylori leading to both a relative and an absolute decrease of gastroduodenal ulcers attributed to H. pylori. Future treatment strategies will have to take these altered prevalence rates into consideration.
Academisch Ziekenhuis Vrije Universitet, afd. Gastro-enterologie, Amsterdam.
N C
NC
van der Weerd
A
A
Cats
J C
JC
Thijs
H P
HP
Festen
S G
SG
Meuwissen
E J
EJ
Kuipers
D000328:Adult; D000368:Aged; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008551:Melena / Q000209:etiology; D009426:Netherlands / Q000453:epidemiology; D010437:Peptic Ulcer / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D015995:Prevalence; D012008:Recurrence; D015043:Zollinger-Ellison Syndrome / Q000150:complications / Q000175:diagnosis*