Apoptosis - when the cells begin to dance.
We present a 24-hour time-lapse videosequence of in vitro behavior of Hep-2 cells treated with 10 m g/ml Etoposide, a topoisomerase II inhibitor. The cell behavior was recorded by a Mitsubishi video recorder, HS-S5600. In the presented sequence, we show the typical cell rounding accompanied by formation of numerous pseudopodia and rapid rhythmical contractions, so called membrane blebbing known as "dance of death".
Rudolf
E
E
Department of Medical Biology and Genetics, Charles University Faculty of Medicine in Hradec Kralove, Simkova 870, 500 01 Hradec Kralove I, Czech Republic. rudolf@lfhk.cuni.cz
Peychl
J
J
Novak
J
J
Cervinka
M
M
D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D018715:Microscopy, Video; D013995:Time; D059005:Topoisomerase II Inhibitors; D014741:Video Recording
D059005:Topoisomerase II Inhibitors; D005047:Etoposide