title: Synthesis and antineoplastic activity of cyclolignan aldehydes.
abstract: Several aldehydes related to methyl 9-deoxy-9-oxo-alpha-apopicropodophyllate, a selective antitumour agent against the HT-29 colon carcinoma, have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). All of them lacked the lactone ring but maintained their cytotoxicity at, or under, the microM level.
authors.affiliation: Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007-, Salamanca, Spain. mliza@gugu.usal.es
authors.forename: M
authors.initials: M
authors.lastname: Gordaliza
authors.forename: M A
authors.initials: MA
authors.lastname: Castro
authors.forename: J M
authors.initials: JM
authors.lastname: Miguel del Corral
authors.forename: M L
authors.initials: ML
authors.lastname: López-Vázquez
authors.forename: P
authors.initials: P
authors.lastname: A García
authors.forename: M D
authors.initials: MD
authors.lastname: García-Grávalos
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000447:Aldehydes; D000970:Antineoplastic Agents; D017705:Lignans