title: [Fatal lactic acidosis in a patient infected by HIV and treated with stavudine and didanosine].
abstract: We report a case of severe lactic acidosis in an human immunodeficiency virus (HIV)-infected patient treated with combination regimen of stavudine, didanosine and nevirapine. Antiretroviral nucleoside analogs are inhibitors of mitochondrial DNA polymerase gamma, resulting in the dysfunction of the mitochondrial respiratory chain. Despite symptomatic treatments and intravenous L-carnitine supplementation, lactic acidosis persisted, leading to multiorgan failure. The patient died 7 days after admission to the intensive care unit. Retrospective analysis of published cases showed neither specific nor predictive signs of outcome that is usually fatal, with no effective therapy to date. We therefore recommend determining blood lactate in patients with onset of unexplained general fatigue or digestive signs and to stop all antiretroviral treatments in the case of lactate increase.
authors.affiliation: CHU Lariboisière, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Mégarbane
authors.forename: D
authors.initials: D
authors.lastname: Goldgran-Tolédano
authors.forename: J M
authors.initials: JM
authors.lastname: Guérin
authors.forename: F
authors.initials: F
authors.lastname: Baud
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase; D016049:Didanosine / Q000009:adverse effects* / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology; D019384:Nucleic Acid Synthesis Inhibitors; D018119:Stavudine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D019384:Nucleic Acid Synthesis Inhibitors; D018119:Stavudine; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase; D016049:Didanosine