Castleman's disease confined to the leptomeninges.
We report a rare case of the plasma cell variant of Castleman's disease confined to the leptomeninges in a 42-year-old female. Flow cytometry demonstrated a minor monoclonal kappa light chain population, and conventional Southern blotting confirmed clonal rearrangement of the J(H) immunoglobulin heavy-chain gene. Polymerase chain reaction for Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus was negative. The patient is disease-free five years after surgical resection. To our knowledge, clonal gene rearrangement has not been previously reported in the plasma cell variant of localized intracranial Castleman's disease.
Cummings
T J
TJ
Duke University Medical Center, Durham, North Carolina, Department of Pathology, 27710, USA. cummi008@mc.duke.edu
Gong
J Z
JZ
Friedman
A H
AH
McLendon
R E
RE
D001099:Arachnoid; D005871:Castleman Disease / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008875:Middle Aged
D007145:Immunoglobulin kappa-Chains