title: Efficient one-step conversion of primary aliphatic amines into primary alcohols: application to a model study for the total synthesis of (+/-)-scopadulin.
abstract: [reaction: see text] Treatment of primary aliphatic amines with KOH in diethylene glycol at 210 degrees C gives primary alcohols directly in good yields. A synthetic application to a model study of (+/-)-scopadulin is also described.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: S M
authors.initials: SM
authors.lastname: Rahman
authors.forename: H
authors.initials: H
authors.lastname: Ohno
authors.forename: N
authors.initials: N
authors.lastname: Maezaki
authors.forename: C
authors.initials: C
authors.lastname: Iwata
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D004224:Diterpenes / Q000138:chemical synthesis*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; C064856:scopadulin