Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease.
We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA. Measurement of CSF levels of NGF may add to the repertoire of potential biochemical diagnostic markers in living AD patients.
Hock
C H
CH
Department of Psychiatry Research, University of Zürich, Switzerland.
Heese
K
K
Olivieri
G
G
Hulette
C H
CH
Rosenberg
C
C
Nitsch
R M
RM
Otten
U
U
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid / Q000378:metabolism*; D010296:Parietal Lobe / Q000378:metabolism; D020917:Receptor, trkA / Q000378:metabolism; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*
D009414:Nerve Growth Factors; D017475:Receptors, Nerve Growth Factor; D020917:Receptor, trkA