Synthesis and antineoplastic activity of cyclolignan aldehydes.
Several aldehydes related to methyl 9-deoxy-9-oxo-alpha-apopicropodophyllate, a selective antitumour agent against the HT-29 colon carcinoma, have been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28). All of them lacked the lactone ring but maintained their cytotoxicity at, or under, the microM level.
Gordaliza
M
M
Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007-, Salamanca, Spain. mliza@gugu.usal.es
Castro
M A
MA
Miguel del Corral
J M
JM
López-Vázquez
M L
ML
A García
P
P
García-Grávalos
M D
MD
San Feliciano
A
A
D000447:Aldehydes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D017705:Lignans / Q000737:chemistry*; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D000447:Aldehydes; D000970:Antineoplastic Agents; D017705:Lignans