Role of CD8 T cells in mycobacterial infections.
The interaction between IFN-gamma-secreting CD4+ T cells and macrophages has long been established as integral in the protective immune response against tuberculosis. More recently, evidence from murine experiments and human studies has begun to demonstrate an essential role for MHC class I restricted CD8+ T cells in this immune response. CD8+ T cells can produce the protective cytokines IFN-gamma and TNF-alpha in addition to their classical cytolytic functions. However, the exact protective mechanisms and antigens recognized by these important cells remain poorly characterized.
Smith
S M
SM
Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom. steven.smith@lshtm.ac.uk
Dockrell
H M
HM
D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D001500:BCG Vaccine; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007158:Immunologic Techniques; D051379:Mice; D009169:Mycobacterium tuberculosis; D014376:Tuberculosis / Q000276:immunology*; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic
D018949:Antigens, CD1; D000945:Antigens, Differentiation, T-Lymphocyte; D001500:BCG Vaccine; D016207:Cytokines; C075005:GNLY protein, human; D015395:Histocompatibility Antigens Class I; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic