Development and influence of inhibition in the lateral superior olivary nucleus.
While studies of neuronal development and plasticity have focused on excitatory pathways, the inhibitory projection from the MNTB to the LSO provides a favorable model for studies of synaptic inhibition. This review covers recent studies from our laboratories indicating that inhibitory connections are quite dynamic during development. These findings suggest that there are two phases inhibitory transmission. During an initial depolarizing phase is growth and branching of pre- and postsynaptic elements in the LSO. During a second hyperpolarizing phase there is refinement of inhibitory afferent arborizations and the LSO dendrites that they innervate.
Sanes
D H
DH
Center for Naeural Science, New York University, NY 10016, USA. sanes@cns.nyu.edu
Friauf
E
E
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005849:Gerbillinae; D018698:Glutamic Acid / Q000502:physiology; D005998:Glycine / Q000502:physiology; D008564:Membrane Potentials; D009434:Neural Pathways / Q000254:growth & development / Q000502:physiology; D009473:Neuronal Plasticity; D009847:Olivary Nucleus / Q000254:growth & development* / Q000502:physiology*; D051381:Rats; D009435:Synaptic Transmission
D018698:Glutamic Acid; D002118:Calcium; D005998:Glycine