In vitro activities of a new ketolide, ABT-773, alone and in combination with amoxicillin, metronidazole, or tetracycline against Helicobacter pylori.
The in vitro activity of ABT-773, a new ketolide, was compared with those of clarithromycin, amoxicillin, metronidazole, and tetracycline against 15 strains of Helicobacter pylori. The MIC of ABT-773 at which 90% of isolates were inhibited was 0.25 microg/ml, which was 3 dilutions higher than that of the most active agent, clarithromycin. Synergy and antagonism were not seen with any combinations. Additive activity was seen with tetracycline, metronidazole, and amoxicillin in 100, 60, and 40% of the combinations, respectively.
Pendland
S L
SL
Microbiology Research Laboratory, Department of Pharmacy Practice, The University of Illinois at Chicago, 60612, USA. pendland@uic.edu
Prause
J L
JL
Neuhauser
M M
MM
Boyea
N
N
Hackleman
J M
JM
Danziger
L H
LH
D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D048628:Ketolides; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D048628:Ketolides; D008795:Metronidazole; D004917:Erythromycin; D000658:Amoxicillin; D013752:Tetracycline; C405499:cethromycin