The synthesis of cyclonucleotides with fixed glycosidic bond linkages as putative agonists for P2-purinergic receptors.
Cyclonucleotides with fixed glycosidic bond linkages were investigated as possible ligands for purinoceptors in PC12 cells. P2Y2-purinoceptors were not activated by the ATP analogue, 8,2'-thioanhydroadenosine-5'-triphosphate (4) and only weakly by the UTP analogue, 2,2' -anhydrouridine-5'-triphosphate (6). However, both analogues were agonists for P2X2-purinoceptors although the potencies were approximately 30-fold less than that of the parent nucleotides.
Tusa
G
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Department of Chemistry, University of Toronto at Mississauga, Ontario.
Reed
J K
JK
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005453:Fluorescence; D008024:Ligands; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D016716:PC12 Cells; D058910:Purinergic P2 Receptor Agonists; D051381:Rats; D018048:Receptors, Purinergic P2 / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D014544:Uridine Triphosphate / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology
D008024:Ligands; D058910:Purinergic P2 Receptor Agonists; D018048:Receptors, Purinergic P2; D000255:Adenosine Triphosphate; D002118:Calcium; D014544:Uridine Triphosphate