title: Computerized equipment for the delivery of inhaled doses of solid particles in specific bronchial challenge.
abstract: An apparatus to generate solid particles was tested for use in diagnosing occupational asthma. This equipment measures the inhaled dose of dry particles during specific inhalation challenge. It includes an aerosol generator, a cyclone type particle size selector, and an inhalation chamber to which a patient breathing at tidal volume can be connected for the test. It is fully controlled by a standard personal computer in automatic mode, acting on the flow rate and the aerosol generator to maintain the concentration at a fixed value, usually 3 mg/m3. The dose of aerosol delivered to the patient was calculated from the aerosol concentration, and the inhaled volume was calculated by integration of the corresponding signals. The coefficient of variation for this measurement was estimated to be 12%. The mass median aerodynamic diameter (MMAD) of aerosol inside the inhalation chamber was measured for three substances: lactose, wheat flour, and buckwheat flour. The MMAD of the aerosol inside the chamber was also estimated from the particle size distribution of the raw powder. The relative difference between the measured MMAD and the calculated value was less than 15%. The corresponding relative difference between the measured geometrical SD and the calculated value was found to be less than 26%.
authors.affiliation: Institut National de Recherche et de Sécurité (INRS), Vandoeuvre, France. fabries@inrs.fr
authors.forename: J F
authors.initials: JF
authors.lastname: Fabriès
authors.forename: D
authors.initials: D
authors.lastname: Choudat
authors.forename: R
authors.initials: R
authors.lastname: Wrobel
authors.forename: Y
authors.initials: Y
authors.lastname: Cloutier
authors.forename: J F
authors.initials: JF
authors.lastname: Dessanges
authors.forename: C
authors.initials: C
authors.lastname: Villette
authors.forename: J
authors.initials: J
authors.lastname: Dall Ava
authors.forename: F
authors.initials: F
authors.lastname: Conso
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000485:Allergens; D001249:Asthma / Q000175:diagnosis*; D001985:Bronchial Provocation Tests / Q000295:instrumentation* / Q000379:methods; D003936:Diagnosis, Computer-Assisted; D004306:Dose-Response Relationship, Immunologic; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006801:Humans; D009330:Nebulizers and Vaporizers; D009784:Occupational Diseases / Q000175:diagnosis*; D010316:Particle Size; D012984:Software
chemical_list: D000336:Aerosols; D000485:Allergens