title: Postoperative management of local colorectal cancer: therapy and surveillance.
abstract: Adjuvant therapy is widely recommended for stage III colon cancer and stages II and III rectal cancer. Although fluorouracil-based regimens are standard, newer agents either alone or in combination may improve response rates. Although nearly all patients enter a postoperative surveillance program after surgical resection, the clinical effectiveness of such surveillance, which is not standardized, is questionable. Critical review of the use of different components (laboratory, radiographic, and endoscopic) of these programs finds little support for intensive surveillance.
authors.affiliation: Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Weinberg
authors.forename: R
authors.initials: R
authors.lastname: Desnoyers
authors.forename: A
authors.initials: A
authors.lastname: Gelmann
authors.forename: B M
authors.initials: BM
authors.lastname: Boman
authors.forename: S A
authors.initials: SA
authors.lastname: Waldman
mesh_terms: D015179:Colorectal Neoplasms / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011182:Postoperative Care