Efficient one-step conversion of primary aliphatic amines into primary alcohols: application to a model study for the total synthesis of (+/-)-scopadulin.
[reaction: see text] Treatment of primary aliphatic amines with KOH in diethylene glycol at 210 degrees C gives primary alcohols directly in good yields. A synthetic application to a model study of (+/-)-scopadulin is also described.
Rahman
S M
SM
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Ohno
H
H
Maezaki
N
N
Iwata
C
C
Tanaka
T
T
D000998:Antiviral Agents / Q000138:chemical synthesis*; D004224:Diterpenes / Q000138:chemical synthesis*; D010946:Plants, Medicinal / Q000737:chemistry
D000998:Antiviral Agents; D004224:Diterpenes; C064856:scopadulin