title: Langerhans cell histiocytosis after therapy for a malignant germ cell tumor of the central nervous system.
abstract: Langerhans cell histiocytosis (LCH) is a clonal neoplastic disorder that results in a spectrum of clinical manifestations. Known to be associated with a variety of malignant diseases, LCH may precede, coincide with, or develop after the diagnosis of cancer. A child with a malignant germ cell tumor of the brain who subsequently experienced LCH is reported. The 8-year-old boy was treated for an immature teratoma of the posterior fossa with gross total resection and craniospinal irradiation preceding bleomycin, etoposide, and vinblastine chemotherapy for four cycles. Seven months after completion of therapy, he experienced multifocal bone disease with LCH.
authors.affiliation: Department of Pediatrics, University of Kentucky, Lexington, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Hale
authors.forename: M F
authors.initials: MF
authors.lastname: Greenwood
authors.forename: J D
authors.initials: JD
authors.lastname: Geil
authors.forename: J A
authors.initials: JA
authors.lastname: Moscow
mesh_terms: D001859:Bone Neoplasms / Q000209:etiology* / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D002648:Child; D006646:Histiocytosis, Langerhans-Cell / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000473:pathology; D013724:Teratoma / Q000473:pathology* / Q000628:therapy