CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months.
This study was designed to determine whether CuZn-superoxide dismutase (SOD) is neuroprotective against aging in the nigrostriatal tract. Twenty-four male mice transgenic for human CuZnSOD, resulting in overexpression of the cytosolic enzyme, were compared with 11 matched controls over 19 months. There was no difference in longevity, locomotor activity, or 3H-mazindol or 3H-spiperone binding in the nigrostriatal tract in the two groups. Thus there was no evidence that increased CuZnSOD was neuroprotective in this model.
Gallagher
I M
IM
Imperial College Medical School, Queen Charlotte's & Chelsea Hospital, London, UK.
Jenner
P
P
Glover
V
V
Clow
A
A
D000818:Animals; D001665:Binding Sites / Q000187:drug effects / Q000235:genetics; D008136:Longevity / Q000235:genetics*; D008297:Male; D008454:Mazindol / Q000494:pharmacology*; D051379:Mice; D008822:Mice, Transgenic / Q000378:metabolism; D009043:Motor Activity / Q000235:genetics*; D017072:Neostriatum / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D009410:Nerve Degeneration / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology; D009434:Neural Pathways / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000378:metabolism; D018384:Oxidative Stress / Q000235:genetics; D013134:Spiperone / Q000494:pharmacology*; D013378:Substantia Nigra / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D014316:Tritium
D018696:Neuroprotective Agents; D014316:Tritium; D013134:Spiperone; D008454:Mazindol; D013482:Superoxide Dismutase