[Endocrinolgy of estrogens: some recent developments and future applications].
The interaction of oestrogens with their intra-nuclear receptor is now recognized in its tri-dimensional aspects. A new receptor, ER beta, has been cloned and new non-genomic oestrogen effects have been reported. Hence, a better understanding of physiological mechanisms or of pathophysiological aspects, such as phyto- and xeno-oestrogens' influence on the organism, is possible. New compounds, belonging to the SERM family, are being explored. Raloxifene is now available for the prevention of post-menopausal osteoporosis. Tamoxifen has been associated with a beneficial effect for the primary prevention of breast cancer in a high-risk population. The understanding of genetic susceptibility could contribute, to better define women at risk. A dedicated primary prevention strategy in women with a high risk of breast cancer coupled with early detection through mammography will continue to improve the prognosis of this hormono-dependent cancer.
Boudes
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Bailly
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D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics; D004703:Endocrine System / Q000502:physiology*; D004967:Estrogens / Q000502:physiology*; D006801:Humans; D011960:Receptors, Estrogen / Q000187:drug effects / Q000235:genetics / Q000502:physiology*
D004967:Estrogens; D011960:Receptors, Estrogen