Glomosporin, a novel antifungal cyclic depsipeptide from Glomospora sp. I. Production, isolation, physico-chemical properties and biological activities.
A novel antifungal cyclic depsipeptide termed glomosporin, which has a fatty acyl side chain, was isolated from a barley solid culture of Glomospora sp. The strain was isolated from fallen pine leaves collected in Fukusima Prefecture, Japan and identified as Glomospora sp. BAUA 2825. Glomosporin was purified by butanol extraction followed by preparative HPLC. Glomosporin showed antimicrobial activity against fungi including clinically important Aspergillus fumigatus.
Sato
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Institute of Biotechnology Applied to Soil Eumycetes, Akita, Japan.
Ishiyama
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Honda
R
R
Senda
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H
Konno
H
H
Tokumasu
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S
Kanazawa
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S
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D047630:Depsipeptides; D005285:Fermentation; D005658:Fungi / Q000145:classification / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*
D000935:Antifungal Agents; D047630:Depsipeptides; D009842:Oligopeptides; C411679:glomosporin