title: Presence of active hepatitis associated with liver cirrhosis is a risk factor for mortality caused by posthepatectomy liver failure.
abstract: The histologic activity of associated hepatitis was examined in 285 patients who underwent hepatectomy for hepatocellular carcinoma (HCC), to determine if the histologic activity is an independent risk factor for postoperative mortality due to liver failure. The proportion of patients with liver cirrhosis who died due to liver failure (6/180, 3.3%) was not different from that of patients with chronic hepatitis (2/68, 2.9%). However, mortality was higher in patients with liver cirrhosis and active hepatitis (4/46, 8.7%) than in those with cirrhosis and inactive hepatitis (2/134, 1.5%, P < 0.05). Such difference was not observed in the chronic hepatitis group. Multivariate analysis showed that clearance of indocyanine green at 15 min (ICGR15) and activity of hepatitis were two independent risk factors for postoperative mortality due to liver failure. In conclusion, histologic activity of associated hepatitis should be taken into account in hepatic resection of HCC in cirrhotic liver, in addition to the functional reserve of the liver.
authors.affiliation: Department of Surgery II, Osaka University Medical School, Suita, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Eguchi
authors.forename: K
authors.initials: K
authors.lastname: Umeshita
authors.forename: M
authors.initials: M
authors.lastname: Sakon
authors.forename: H
authors.initials: H
authors.lastname: Nagano
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: S I
authors.initials: SI
authors.lastname: Kishimoto
authors.forename: K
authors.initials: K
authors.lastname: Dono
authors.forename: S
authors.initials: S
authors.lastname: Nakamori
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: K
authors.initials: K
authors.lastname: Wakasa
authors.forename: N
authors.initials: N
authors.lastname: Matsuura
authors.forename: M
authors.initials: M
authors.lastname: Monden
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000601:surgery; D002908:Chronic Disease; D005260:Female; D006498:Hepatectomy; D006505:Hepatitis / Q000150:complications / Q000473:pathology; D006521:Hepatitis, Chronic / Q000150:complications* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D017093:Liver Failure / Q000401:mortality*; D008113:Liver Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality*; D012189:Retrospective Studies; D012307:Risk Factors