title: Follow-up of melanocytic skin lesions with digital epiluminescence microscopy: patterns of modifications observed in early melanoma, atypical nevi, and common nevi.
abstract: BACKGROUND
  Digital epiluminescence microscopy (DELM) has been reported to be a useful technique for the follow-up of melanocytic nevi. One of the promises of this technique is to identify modifications over time that indicate impending or incipient malignancy and to facilitate surveillance of melanocytic skin lesions, particularly in patients with multiple clinically atypical nevi.
  
  
  OBJECTIVE
  Our purpose was to report on patterns of modifications over time observed in benign melanocytic skin lesions and melanoma.
  
  
  METHODS
  A total of 1862 sequentially recorded DELM images of melanocytic lesions from 202 patients (mean age, 36.1 years; 54.0% female patients) with multiple clinically atypical nevi were included in the analysis. The median follow-up interval was 12. 6 months. Melanocytic lesions with substantial modifications over time (enlargement, changes in shape, regression, color changes or appearance of ELM structures known to be associated with melanoma) were excised and referred to histopathologic examination.
  
  
  RESULTS
  A total of 75 melanocytic skin lesions (4.0%) from 52 patients (mean age, 33.3 years; 63.5% female patients) showed substantial modifications over time and were excised and referred to histopathologic examination. Eight changing lesions were histologically diagnosed as early melanomas. These lesions frequently showed focal enlargement associated with a change in shape as well as appearance of ELM structures that are known to be associated with melanoma. In contrast, the majority of benign changing lesions (common and atypical nevi) showed symmetric enlargement without substantial structural ELM changes. Six of the 8 patients in whom melanoma developed were unaware of the fact that the lesion had changed over time.
  
  
  CONCLUSIONS
  We demonstrate that follow-up of melanocytic lesions with DELM helps to identify patterns of morphologic modifications typical for early melanoma. DELM may therefore serve as a useful tool to improve the surveillance of patients with multiple atypical nevi.
authors.affiliation: Department of Dermatology, Division of General Dermatology, University of Vienna Medical School, Austria. h.kittler@akh-wien.ac.at
authors.forename: H
authors.initials: H
authors.lastname: Kittler
authors.forename: H
authors.initials: H
authors.lastname: Pehamberger
authors.forename: K
authors.initials: K
authors.lastname: Wolff
authors.forename: M
authors.initials: M
authors.lastname: Binder
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008853:Microscopy / Q000379:methods; D009367:Neoplasm Staging / Q000379:methods; D009508:Nevus, Pigmented / Q000473:pathology*; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology*; D012880:Skin Pigmentation