title: Cerebral tissue oxygen saturation during percutaneous cardiopulmonary support in a canine model of respiratory failure.
abstract: Percutaneous cardiopulmonary support (PCPS) has come to be applied for cardiopulmonary resuscitation and in the management of severe respiratory failure as well as severe heart failure. We investigated cerebral tissue oxygen saturation during PCPS in a canine model of respiratory failure using near-infrared spectroscopy. Animals were mechanically ventilated with 10% oxygen to make a respiratory failure model. Perfusion with PCPS was performed via the left femoral artery and switched to that via the right axillary artery. Cerebral tissue oxygen saturation was 54.2 +/- 3.4% during PCPS via the femoral artery and was 82.3 +/- 4.6% during PCPS via the axillary artery (p = 0.001). Hepatic tissue oxygen saturation was not significantly different. LV dP/dt max increased significantly after switching to the axillary blood supply (p = 0.001). Conventional PCPS may not have the capability of supporting cerebral circulation under severe respiratory failure without organic heart disease.
authors.affiliation: First Department of Surgery, Hiroshima University School of Medicine; and Department of Clinical Engineering, Hiroshima International University, Hiroshima, Japan. hwada@mcai.med.hiroshima-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: M
authors.initials: M
authors.lastname: Watari
authors.forename: T
authors.initials: T
authors.lastname: Sueda
authors.forename: K
authors.initials: K
authors.lastname: Kochi
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Shibamura
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: S
authors.initials: S
authors.lastname: Fukunaga
authors.forename: K
authors.initials: K
authors.lastname: Orihashi
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuura
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001243:Assisted Circulation / Q000379:methods*; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D015199:Extracorporeal Membrane Oxygenation; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D012131:Respiratory Insufficiency / Q000503:physiopathology; D019265:Spectroscopy, Near-Infrared
chemical_list: D010100:Oxygen