title: Response of the ruminant respiratory tract to Mannheimia (Pasteurella) haemolytica.
abstract: Pneumonia is a leading cause of loss to the sheep and cattle industry throughout the world. Mannheimia (Pasteurella) haemolytica is one of the most important respiratory pathogens of domestic ruminants and causes serious outbreaks of acute pneumonia in neonatal, weaned and growing lambs, calves, and goats. M. haemolytica is also an important cause of pneumonia in adult animals. Transportation, viral infections with agents such as infectious bovine rhinotracheitis virus, parainfluenza-3 virus or bovine respiratory syncytial virus, overcrowding, housing of neonates and weaned animals together and other stressful conditions predispose animals to M. haemolytica infection [1, 2]. This review assimilates some of the findings key to cellular and molecular responses of the lung from a pathologist's perspective. It includes some of what is known and underscores areas that are not fully understood.
authors.affiliation: Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Ackermann
authors.forename: K A
authors.initials: KA
authors.lastname: Brogden
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control; D015815:Cell Adhesion Molecules / Q000032:analysis; D015511:Goat Diseases / Q000276:immunology / Q000382:microbiology*; D006041:Goats; D008168:Lung / Q000276:immunology / Q000382:microbiology; D016676:Macrophages, Alveolar / Q000276:immunology; D016978:Mannheimia haemolytica; D008407:Mast Cells / Q000276:immunology; D008854:Microscopy, Electron; D009504:Neutrophils / Q000276:immunology; D010326:Pasteurella Infections / Q000662:veterinary*; D018410:Pneumonia, Bacterial / Q000662:veterinary*; D020545:Respiratory Mucosa / Q000276:immunology / Q000382:microbiology; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000382:microbiology*
chemical_list: D015815:Cell Adhesion Molecules