MAGUK proteins: structure and role in the tight junction.
ZO-1, ZO-2 and ZO-3 are tight junction (TJ)-associated proteins that belong to the MAGUK family. In addition to the presence of the characteristic MAGUK modules (PDZ, SH3 and GK), ZOs have a distinctive carboxyl terminal with splicing domains, acidic- and proline-rich regions. The modular organization of these proteins allows them to function as scaffolds, which associate to transmembrane TJ proteins, the cytoskeleton and signal transduction molecules. ZOs shuttle between the TJ and the nucleus, where they may regulate gene expression.
González-Mariscal
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Department of Physiology, Biophysics and Neurosciences, Center of Research and Advanced Studies (CINVESTAV), Ap. Postal 14-740, Mexico DF, 07000, Mexico. lorenza@fisio.cinvestav.mx
Betanzos
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Avila-Flores
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D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000502:physiology; D018031:Connexin 43 / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D051528:Guanylate Kinases; D006801:Humans; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D009703:Nucleoside-Phosphate Kinase / Q000737:chemistry* / Q000502:physiology*; D062793:Occludin; D010750:Phosphoproteins / Q000737:chemistry / Q000502:physiology; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D019108:Tight Junctions / Q000502:physiology*; D062825:Zonula Occludens Proteins; D062826:Zonula Occludens-1 Protein; D062827:Zonula Occludens-2 Protein; D018909:src Homology Domains
D002352:Carrier Proteins; D018031:Connexin 43; D046911:Macromolecular Substances; D008565:Membrane Proteins; C568985:OCLN protein, human; D062793:Occludin; D010750:Phosphoproteins; C569042:TJP1 protein, human; C569046:TJP2 protein, human; C111873:TJP3 protein, human; D062825:Zonula Occludens Proteins; D062826:Zonula Occludens-1 Protein; D062827:Zonula Occludens-2 Protein; D009703:Nucleoside-Phosphate Kinase; D051528:Guanylate Kinases