Protective effect of leaf extract of Ficus hispida Linn. against paracetamol-induced hepatotoxicity in rats.
The methanol extract of the leaves of Ficus hispida Linn. (Moraceae) was evaluated for hepatoprotective activity in rats by inducing acute liver damage by paracetamol (750 mg/kg, p.o.). The extract at an oral dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of Liv-52 a known hepatoprotective formulation.
Mandal
S C
SC
Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta - 700 032, India. abhi@juphys.ernet.in
Saraswathi
B
B
Kumar
C K
CK
Mohana Lakshmi
S
S
Maiti
B C
BC
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D005260:Female; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales
D010936:Plant Extracts; D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin