Cerebellar cortical abiotrophy in two Portuguese Podenco littermates.
Cerebellar cortical abiotrophy in two Portuguese Podenco littermates is reported and discussed. The disease is characterized by progressive cerebellar ataxia with an early onset of two to three weeks. Extensive loss, degeneration, and necrosis of Purkinje cells particularly involved the cerebellar hemispheres. An autosomal recessive pattern of inheritance is suspected.
van Tongern
S E
SE
Department of Veterinary Pathology, University Utrecht, The Netherlands.
van Vonderen
I K
IK
van Nes
J J
JJ
van den Ingh
T S
TS
D000818:Animals; D001947:Breeding; D002525:Cerebellar Cortex / Q000473:pathology*; D002526:Cerebellar Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D008297:Male; D011174:Portugal; D011689:Purkinje Cells / Q000473:pathology