title: Benign central neurocytoma.
abstract: BACKGROUND
  "Central neurocytoma" is classically considered as an intraventricular benign tumor, largely based on data from small retrospective series. The authors present prospective data on 12 patients with tumors diagnosed as central neurocytoma, to highlight the diverse nature of this tumor and challenge the classic notion.
  
  
  METHODS
  Between 1991 and 1997, 12 patients had tumors diagnosed prospectively as "central neurocytoma". Clinical, radiologic, and histologic data were collected, and Karnofsky performance score was evaluated for each patient. Proliferation marker studies were performed using Ki-67 labeling index.
  
  
  RESULTS
  In two patients, the tumors were located in atypical locations, namely, the parietal lobe and the spine. Aggressive behavior characterized by clinical and radiologic evidence of tumor progression was noted in two additional patients. In both these cases, unusually high proliferation rates of 5.3% and 11.2% were noted. Total excision of the tumor, when possible, was the treatment of choice. Postoperative radiotherapy to the residual tumor may be of benefit in patients with clinically aggressive tumors, or those with high proliferation rates.
  
  
  CONCLUSIONS
  Given the findings of this study, it is suggested that the traditional concept of central neurocytoma as a benign intraventricular tumor warrants reconsideration.
authors.affiliation: Departments of Neurological Surgery and Neuropathology, National Hospital for Neurology and Neurosurgery, London, England.
authors.forename: K
authors.initials: K
authors.lastname: Ashkan
authors.forename: A T
authors.initials: AT
authors.lastname: Casey
authors.forename: C
authors.initials: C
authors.lastname: D'Arrigo
authors.forename: W F
authors.initials: WF
authors.lastname: Harkness
authors.forename: D G
authors.initials: DG
authors.lastname: Thomas
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D018306:Neurocytoma / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D010296:Parietal Lobe / Q000473:pathology; D011446:Prospective Studies; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000209:etiology; D013131:Spine / Q000473:pathology
chemical_list: D019394:Ki-67 Antigen