[Celecoxib vs indomethacin and acute gastric lesions in rats].
In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied. Celecoxib was given each 12 hs orally and subcutaneously during 5 days and gastrointestinal lesions were not found; in contrast, Celecoxib given after indomethacin aggravated antrum gastric ulcers (p < 0.001); intestinal massive necrosis and death were observed in all the rats. We conclude that Celecoxib does not induce gastrointestinal lesions in healthy mucosa; in contrast, Celecoxib amplifies the gastrointestinal lesions induced by indomethacin.
Laudanno
O M
OM
Cátedra de Patología Médica III e Histología y Embriología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina.
Esnarriaga
J M
JM
Cesolari
J A
JA
Maglione
C B
CB
Aramberry
L J
LJ
Sambrano
J S
JS
Piombo
G
G
Rista
L
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000633:toxicity*; D004064:Digestive System / Q000187:drug effects*; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009336:Necrosis; D011706:Pyloric Antrum / Q000293:injuries; D011720:Pyrazoles; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology; D013449:Sulfonamides / Q000008:administration & dosage / Q000633:toxicity*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib; D007213:Indomethacin