[Multiple medullary and extramedullary plasmacytomas in an HIV infected female patient].
BACKGROUND
Before the HIV infection era, plasmocyte tumor rarely occurred in patients younger than 40 years of age. Less frequent than lymphomas, the incidence of these blood diseases has however substantially increased in HIV-infected patients. In these patients, in addition to onset at earlier age, their clinical presentation is quite different and extramedullary plasmocytomas in unexpected locations are more common.


METHODS
We report the case of a 29-year-old HIV-infected female patient in whom were diagnosed occipital, parotidal, sphenoidal, epidural, and uterine plasmocytomas for which chemotherapy and subsequent radiotherapy were successful. The increase in the incidence of plasmocyte tumors in HIV-infected patients might be facilitated by Epstein Barr Virus (EBV) co-infection, HIV-related chronic antigenic stimulation, and secretion of interleukin 6 by infected lymphocytes.


CONCLUSIONS
Plasmocyte tumors belong to neoplasia whose incidence is increased in HIV infection. Their currently poor diagnosis should be improved by highly active antiretroviral therapies allowing enhanced chemotherapy with possibility of autograft.
Delèvaux
I
I
Service de médecine interne et de maladies infectieuses, hôpital Saint-André, Bordeaux, France.
Bernard
N
N
Ramanampamonjy
R
R
Morlat
P
P
Lacoste
D
D
Bonnet
F
F
Bonnel
C
C
Deminière
C
C
Beylot
J
J
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D002180:Candidiasis, Oral / Q000188:drug therapy; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D009101:Multiple Myeloma / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000532:radiotherapy
D000935:Antifungal Agents; D015725:Fluconazole