[Serum levels of NO products, IL-8, RANTES and eotaxin in infantile patients with atopic dermatitis].
Inflammatory mechanisms play an important role in the pathogenesis and the expansion of the skin lesion in AD. The serum levels of NO product, IL-8, RANTES and eotaxin, which are considered to an index of the inflammatory response, were measured in infants diagnosed as AD. The serum levels of NO product, RANTES and eotaxin were higher in the infantile AD patients with the systemic skin lesion compared with controls. The higher levels of NO product were shown with the expansion of the skin lesion. In AD patients, the serum levels of NO product were significantly correlated with the serum levels of eotaxin (r = 0.615, p < 0.001). These results suggest that NO product bears an important function in the allergic inflammation, which is concerned with the lesion expansion of the infantile AD patients and may be an index of the allergic inflammation.
Kurita
F
F
Second Department of Pediatrics, Toho University, Tokyo, Japan.
D054413:Chemokine CCL11; D018946:Chemokine CCL5 / Q000097:blood*; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil / Q000097:blood*; D016207:Cytokines / Q000097:blood*; D003876:Dermatitis, Atopic / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood*
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D018946:Chemokine CCL5; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D016207:Cytokines; D016209:Interleukin-8; D009569:Nitric Oxide