title: Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in human bone cell conditioned medium do not change with age.
abstract: We examined the effects of age on the secretion of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in long-term bone cell cultures from 71 female donors, aged 28-79 years. Our results suggest that under basal conditions, the intrinsic capacity of human bone cells to produce these IGF components is largely preserved with age.
authors.affiliation: Kliniken Bergmannsheil, Department of Internal Medicine, University of Bochum, Bochum, Germany. johannes.pfeilschifter@ruhr-uni-bochum.de
authors.forename: J
authors.initials: J
authors.lastname: Pfeilschifter
authors.forename: I
authors.initials: I
authors.lastname: Diel
authors.forename: T
authors.initials: T
authors.lastname: Klöppinger
authors.forename: H
authors.initials: H
authors.lastname: Bismar
authors.forename: E M
authors.initials: EM
authors.lastname: Schuster
authors.forename: S
authors.initials: S
authors.lastname: Balbach
authors.forename: R
authors.initials: R
authors.lastname: Ziegler
authors.forename: D
authors.initials: D
authors.lastname: Baylink
authors.forename: S
authors.initials: S
authors.lastname: Mohan
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D005260:Female; D006801:Humans; D007085:Ilium / Q000166:cytology / Q000378:metabolism; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000378:metabolism*; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D017077:Culture Media, Conditioned; D018974:Insulin-Like Growth Factor Binding Protein 4; D018975:Insulin-Like Growth Factor Binding Protein 5; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II