title: Function of hollow viscera in children with constipation and voiding difficulties.
abstract: We wished to investigate the urodynamic characteristics and colonic motility in a group of children with severe chronic constipation and lower urinary tract symptoms. We performed colonic manometry using an endoscopically placed catheter. The urodynamic studies consisted of cystometry, electromyography of the external urethral sphincter, measurement of urinary flow rate, and urethral pressure profile. We found abnormal colonic motility in all patients. Findings included: absent gastrocolonic response (N = 8), absent high-amplitude propagated contractions (HAPCs) (N = 4), and abnormal propagation of HAPCs (N = 7). Urodynamic features were abnormal in 10 children. Findings included: uninhibited bladder contractions (N = 6), hypertonic bladder (N = 2), sphincter dyssynergy (N = 2), small capacity bladder (N = 1). In all children constipation improved, in three after a partial colectomy. Urinary symptoms persisted. We conclude that some children with severe constipation may have a neuropathy affecting both the colonic and lower urinary tracts systems. In this group of patients treatment of constipation does not result in resolution of urinary symptoms.
authors.affiliation: Department of Pediatrics, Children's Hospital of Pittsburgh, Pennsylvania 15213, USA.
authors.forename: C
authors.initials: C
authors.lastname: Lucanto
authors.forename: S B
authors.initials: SB
authors.lastname: Bauer
authors.forename: P E
authors.initials: PE
authors.lastname: Hyman
authors.forename: A F
authors.initials: AF
authors.lastname: Flores
authors.forename: C
authors.initials: C
authors.lastname: Di Lorenzo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003106:Colon / Q000503:physiopathology; D003248:Constipation / Q000503:physiopathology* / Q000628:therapy; D004064:Digestive System / Q000503:physiopathology*; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D013270:Stomach / Q000503:physiopathology; D014521:Urethra / Q000503:physiopathology; D001743:Urinary Bladder / Q000503:physiopathology; D014551:Urinary Tract / Q000503:physiopathology*; D014555:Urination Disorders / Q000503:physiopathology* / Q000628:therapy; D014563:Urodynamics