The roles of activins, inhibins and estrogen in early committed follicles.
The hypothesis that activin and inhibin are autocrine/paracrine mediators of ovarian folliculogenesis has a solid basis. In mouse and rat models, granulosa cells (GC) of committed follicles express mRNA and protein for the activin/inhibin subunits and mRNA for the activin receptors (type I and II). Dimeric inhibin-A and -B are produced by postnatal ovarian cell dispersates and (GC) in culture. Similar levels of inhibin-A and -B are produced by postnatal ovarian cells, but thereafter as the ovary develops, inhibin-A becomes the predominant form. Activin was more effective than transforming growth factor-beta (TGF-beta) in enhancing follicle stimulating hormone (FSH)-stimulated inhibin production by ovarian cells. Evidence for a local regulatory role of estrogen in the ovary is also accumulating. Murine models of estrogen receptor (ERalpha or ERbeta) disruption produce mice with abnormal ovarian phenotypes. Female mice, which lack the capacity to produce estrogen (ArKO mice), have arrested folliculogenesis, no corpora lutea, elevated levels of luteinising hormone (LH), FSH and testosterone and are infertile. These data are consistent with autocrine/paracrine actions of activin in the early growth of committed follicles and estrogen in follicular maturation.
Findlay
J K
JK
Prince Henry's Institute of Medical Research, P.O. Box 5152, Vic. 3168, Clayton, Australia. jock.findlay@med.monash.edu.au
Drummond
A E
AE
Britt
K L
KL
Dyson
M
M
Wreford
N G
NG
Robertson
D M
DM
Groome
N P
NP
Jones
M E
ME
Simpson
E R
ER
D028341:Activins; D000818:Animals; D004967:Estrogens / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D005260:Female; D007265:Inhibins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D006080:Ovarian Follicle / Q000378:metabolism* / Q000502:physiology; D011960:Receptors, Estrogen / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D028341:Activins; D007265:Inhibins