[Genetic aspects of arterial hypertension: the role of Y chromosome and mitochondrial DNA].
A study on hybrids from reciprocal crossing of the SHR-SP and the WKY has shown that Y-chromosome and mitochondrial DNA the affect development of the spontaneous hypertension. The Y-chromosome takes part in disorders of baroreceptive sensitivity in phenylnephrine assay associated with hypertension. Although our findings suggest that structural remodelling of peripheral vascular resistance and an increase in noradrenaline-dependent vasocostriction is genetically determined in hypertensive rats, we could not corroborate the role of the Y-chromosome and mitochondrial DNA in the process. A difference was shown between male and female SHR-SP in the level of arterial pressure and in development of the vascular structure changes.
Monastyrskaia
E A
EA
Moscow State University, Russia.
Murashev
A N
AN
Khokhlova
O N
ON
Saprunova
V B
VB
Korshunov
V A
VA
Koshelev
V B
VB
D000818:Animals; D017704:Baroreflex; D004272:DNA, Mitochondrial; D005260:Female; D006614:Hindlimb / Q000098:blood supply; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014655:Vascular Resistance; D014998:Y Chromosome
D004272:DNA, Mitochondrial