title: [Retinoic acid syndrome. Severe respiratory insufficiency treated with CPAP].
abstract: Retinoic acid syndrome is a potentially life-threatening complication of therapy for acute promyelocytic leukemia (APL) with all-transretinoic acid (ATRA). The case of a 55-year old male patient admitted to the hospital because of a bleeding diathesis is reported. APL was diagnosed and he underwent treatment with idarubicin and ATRA (GIMEMA protocol); 24 hrs after ATRA treatment he developed retinoic acid syndrome and was admitted to the Intensive Care Unit because of severe respiratory insufficiency (dyspnoea, tachypnea and severe hypoxemia (SpO2 75%). Pulmonary insufficiency was treated non-invasively with CPAP and the patient recovered from pulmonary distress one week later.
authors.affiliation: Cattedra di Anestesiologia e Rianimazione, IRCCS H San Raffaele, Università degli Studi, Milano. tommasino.concezione@hsr.it
authors.forename: C
authors.initials: C
authors.lastname: Tommasino
authors.forename: L
authors.initials: L
authors.lastname: De Felice
authors.forename: S
authors.initials: S
authors.lastname: Colombo
authors.forename: D
authors.initials: D
authors.lastname: Salaris
authors.forename: T
authors.initials: T
authors.lastname: Capocasa
authors.forename: D
authors.initials: D
authors.lastname: Giudici
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy; D008297:Male; D011859:Radiography; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy*; D014212:Tretinoin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin