rIL-2-stimulated splenocytes reactivate the NO2-producing ability of macrophages infected by Leishmania donovani.
Infection with L. donovani down-regulates immunity and parasite clearance by macrophages. Treatment with IL-2-stimulated-splenocytes activate parasiticidal action in vitro in peritoneal macrophages of C57BL/6 (Lsh(s)) mice and also was effective in stimulating infected macrophages to produce NO2-.
Eslami
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Institute of Parasitology of McGill University, Ste-Anne-de-Bellevue, Quebec, Canada.
Tanner
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D000818:Animals; D006224:Cricetinae; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000494:pharmacology*; D007893:Leishmania donovani / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D008262:Macrophage Activation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000378:metabolism* / Q000469:parasitology; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D009585:Nitrogen Dioxide / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology*; D013481:Superoxides / Q000378:metabolism
D007376:Interleukin-2; D011994:Recombinant Proteins; D013481:Superoxides; D006861:Hydrogen Peroxide; D009585:Nitrogen Dioxide