Cefodizime in skin suction blister fluid and serum following a single intravenous or intramuscular dose in adult patients.
Cefodizime is a third generation cephalosporin for parenteral use. The pharmacokinetics of this cephem antibiotic were determined in serum and skin suction blister fluid (SBF) after intravenous (i.v.) or intramuscular (i.m.) administration of a single 1 g dose in 8 adult patients with normal renal and hepatic function who volunteered for the study. The concentration versus time curve showed a slower elimination rate from the extravascular compartment: the half-lives were 4.4+/-0.5 and 5.4+/-0.4 hours after i.v. and i.m. route respectively. The relatively long elimination half-life in SBF with a mean residence time of about 8 hours allows the use of cefodizime once-a-day for the treatment of infections due to sensitive pathogens.
Mazzei
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T
Department of Pharmacology, University of Florence, Italy.
Novelli
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A
Esposito
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Fallani
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S
Noviello
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S
Cassetta
M I
MI
Conti
S
S
Periti
P
P
D000328:Adult; D001768:Blister / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008297:Male; D012140:Respiratory Tract Diseases / Q000097:blood / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D013396:Suction
D002511:Cephalosporins; D002439:Cefotaxime; C033356:cefodizime