[Reversible cyclosporin A-induced leukoencephalopathy: a case report and differential diagnosis discussion].
The pathogenesis of Cyclosporin A (CsA) induced toxic leukoencephalopathy is unclear. CCT and CMRI reveal hypodense respectively hyperintense bilateral and symmetrical changes predominantly in the posterior white matter. We report a patient with a severe CsA induced toxic leukoencephalopathy in whom clinical symptoms (complete loss of brainstem functions, coma) and morphological changes in CCT and CMRI were completely reversible after immunosuppression with CsA has been stopped. We furthermore discuss the differential diagnoses of CCT and CMRI findings.
Lingesleben
A
A
Klinikum Buch, Akademisches Lehrkrankenhaus der Charité, Humboldt-Universität zu Berlin.
Hoffmann
K T
KT
Oppert
M
M
Irlbacher
K
K
Röricht
S
S
Meyer
B U
BU
D000328:Adult; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D015140:Dementia, Vascular / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D011182:Postoperative Care; D014057:Tomography, X-Ray Computed
D007166:Immunosuppressive Agents; D016572:Cyclosporine