An open-label trial of bromocriptine in nonfluent aphasia: a qualitative analysis of word storage and retrieval.
Anomia is a commonly found in aphasia and has been attributed to a loss of representations (storage deficit) or to a loss of access to these representations (retrieval deficit). Bromocriptine, a dopamine agonist, was tested on four patients, two men and two women, with nonfluent aphasia. The patients were tested in an open-label ABBA design using a stochastic model that measured the degree of storage and retrieval deficits. All patients showed significant improvements in word retrieval. Bromocriptine may be a useful adjunct in the treatment of selected patients with a nonfluent aphasia in which retrieval deficits play a major role.
Gold
M
M
Department of Neurology, University of South Florida College of Medicine, Tampa, 33612, USA. mgold@com1.med.usf.edu
VanDam
D
D
Silliman
E R
ER
D000368:Aged; D001039:Aphasia, Broca / Q000188:drug therapy*; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000187:drug effects; D014705:Verbal Behavior / Q000187:drug effects*; D014825:Vocabulary
D018491:Dopamine Agonists; D001971:Bromocriptine