Nuclear receptor versus plasma membrane oestrogen receptor.
The co-existence of both plasma membrane and nuclear oestrogen receptors has changed our thinking about the mechanisms of the actions of this sex steroid. To date, however, the plasma membrane receptor has not been isolated. However, many emerging data implicate this receptor in the rapid, non-genomic effects of oestrogen, and this is seen when the membrane receptor effects a variety of signal transduction events. Although discrete actions of oestradiol could be mediated through the plasma membrane receptor, there is probably often a coordination of effects mediated through both receptors, perpetuating and magnifying the cell biological effects of the steroid.
Levin
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Division of Endocrinology, Veterans Affairs Medical Center, Long Beach, CA 90822, USA.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002319:Cardiovascular System / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D006801:Humans; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*
D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D004958:Estradiol