title: Effect of combined therapy of oral anti-tubercular agents on theophylline pharmacokinetics.
abstract: To evaluate the effects of combined therapy of anti-tubercular agents with theophylline during treatment of concurrent pulmonary tuberculosis and chronic obstructive pulmonary disease or asthma, the clearance and half life of theophylline was estimated in a control group not treated with anti-tubercular agents, a group treated with isoniazid (INH), rifampicin (RMP), ethambutol (EMB) and pyrazinamide (PZA), and a group treated with INH, RMP and EMB. Clearances of theophylline in the treated groups were significantly lower than in the control group, and the half-life of theophylline was longer than in the control. These results suggest that patients administered combinations of anti-tubercular agents with theophylline require lower doses of theophylline.
authors.affiliation: Department of Pharmacy, Woosuk University, South Korea.
authors.forename: H C
authors.initials: HC
authors.lastname: Ahn
authors.forename: J H
authors.initials: JH
authors.lastname: Yang
authors.forename: H B
authors.initials: HB
authors.lastname: Lee
authors.forename: Y K
authors.initials: YK
authors.lastname: Rhee
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013806:Theophylline / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D013806:Theophylline