title: HIV-1 subtypes in injecting drug users & their non-injecting wives in Manipur, India.
abstract: The presence of HIV-1 antibodies was determined among the injecting drug users (IDUs) and their non-injecting wives. A total of 233 (72%) were found to be HIV-1 seropositive among the 322 subjects recruited in this study between August, 1996 and September, 1997. The distribution of HIV-1 subtypes among the injecting drug users (IDUs) and their wives was determined using peptide enzyme immunoassay (EIA). Sexual transmission of HIV-1 occurred frequently (45%) from HIV-1 infected IDUs to their spouses. The majority of the subjects (167/233) were infected with subtype C followed by subtype Thai B (29/233). Subtype C was the most common among both IDUs (78%) and their wives (57%), followed by subtype Thai B (12% and 13% respectively). The distribution of subtypes was significantly different between IDUs and their wives with a lower percentage of subtype C and higher percentage of subtype D in the infected wives (P < 0.03). Discordance for subtypes transmitted from IDUs to their wives suggests the occurrence of dual and/or recombinant infection in the IDUs.
authors.affiliation: National Institute of Cholera & Enteric Diseases (ICMR), Calcutta.
authors.forename: S
authors.initials: S
authors.lastname: Chakrabarti
authors.forename: S
authors.initials: S
authors.lastname: Panda
authors.forename: A
authors.initials: A
authors.lastname: Chatterjee
authors.forename: S
authors.initials: S
authors.lastname: Sarkar
authors.forename: B
authors.initials: B
authors.lastname: Manna
authors.forename: N B
authors.initials: NB
authors.lastname: Singh
authors.forename: T N
authors.initials: TN
authors.lastname: Naik
authors.forename: R
authors.initials: R
authors.lastname: Detels
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
mesh_terms: D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D015497:HIV-1 / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007194:India; D008297:Male; D018454:Spouses; D015819:Substance Abuse, Intravenous / Q000276:immunology / Q000821:virology*
chemical_list: D015483:HIV Antibodies