title: Cloning and characterisation of ITGAV, the genomic sequence for human cell adhesion protein (vitronectin) receptor alpha subunit, CD51.
abstract: The integrin family of receptors serves as major receptors for extracellular matrix-mediated cell adhesion and migration, cytoskeletal organisation, cell proliferation, survival, and differentiation. The alpha-V integrins consist of a subset which share a common alpha-V subunit combined with one of five beta subunits (beta-1, 3, 5, 6, or 8). The alpha-V integrins have been implicated in a number of developmental processes, including vasculogenesis and angiogenesis, and are therapeutic targets for inhibition of angiogenesis and osteoporosis. The human cDNA for alpha-V integrin (ITGAV) consists of a 5,717-bp transcript with a coding sequence (CDS) of 3,146 bp encoding a 150-kDa mature peptide. Here we describe the gene structure of ITGAV.
authors.affiliation: Genetic Technologies, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Sims
authors.forename: S D
authors.initials: SD
authors.lastname: Field
authors.forename: M R
authors.initials: MR
authors.lastname: Barnes
authors.forename: N
authors.initials: N
authors.lastname: Shaikh
authors.forename: K
authors.initials: K
authors.lastname: Ellington
authors.forename: K E
authors.initials: KE
authors.lastname: Murphy
authors.forename: N
authors.initials: N
authors.lastname: Spurr
authors.forename: D A
authors.initials: DA
authors.lastname: Campbell
mesh_terms: D015703:Antigens, CD / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005091:Exons; D005796:Genes / Q000235:genetics; D006801:Humans; D039564:Integrin alphaV; D007438:Introns; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D016324:Sequence Tagged Sites
chemical_list: D015703:Antigens, CD; D039564:Integrin alphaV; D004247:DNA