title: The invasion-associated type III secretion system of Salmonella typhimurium: common and unique features.
abstract: Several bacterial pathogens make use of a specialized protein secretion system to inject effector proteins into host cells. This system, commonly referred to as type III secretion, is always associated with phenotypes related to intimate interactions between the pathogen and its respective host cells. The enteric pathogen Salmonella typhimurium utilizes a type III secretion system to invade nonphagocytic intestinal epithelial cells. Whereas the invasion-associated type III system of S. typhimurium has evolved to perform a specific function, many of the components of this system are conserved among the type III systems of other bacterial pathogens. This review will discuss the common and unique features of the S. typhimurium system in relation to the type III systems of other human pathogens. Topics discussed include the phenotypes associated with various type III systems, the genetic loci encoding these systems, the components of the type III secretion apparatus, the effector proteins and the mechanisms by which they enter host cells as well as the mechanisms used to regulate the expression of type III systems.
authors.affiliation: Section of Microbial Pathogenesis, Boyer Center for Molecular Medicine, Yale School of Medicine, New Haven, Connecticut 06536, USA. anand.sukhan@yale.edu
authors.forename: A
authors.initials: A
authors.lastname: Sukhan
mesh_terms: D017209:Apoptosis; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport; D003599:Cytoskeleton / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008264:Macrophages / Q000473:pathology; D018832:Molecular Chaperones / Q000378:metabolism; D020559:Monomeric GTP-Binding Proteins / Q000378:metabolism; D010766:Phosphorylation; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012480:Salmonella Infections / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*
chemical_list: D001426:Bacterial Proteins; D018832:Molecular Chaperones; D012333:RNA, Messenger; D020559:Monomeric GTP-Binding Proteins