title: Transformation of hepatitis B virus-related membranous glomerulonephritis to crescentic form.
abstract: We report a case of hepatitis B virus-(HBV) related membranous glomerulonephritis which progressed to crescentic transformation after withdrawal of immunosuppressive treatment. Immunosuppressive therapy probably enhanced HBV replication, and its withdrawal led to a return of immune competence resulting in progression of the glomerulonephritis. Prior screening of all patients for hepatitis B surface antigen, before using immunosuppressive therapy may prevent this complication. The usage of immunosuppressive therapy as a first-line choice in HBV-related glomerulonephritis may result in harmful complications.
authors.affiliation: Nephrology Department of Erciyes University Medical School, Kayseri, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Taskapan
authors.forename: O
authors.initials: O
authors.lastname: Oymak
authors.forename: A
authors.initials: A
authors.lastname: Dogukan
authors.forename: O
authors.initials: O
authors.lastname: Ozbakir
authors.forename: C
authors.initials: C
authors.lastname: Utas
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000473:pathology*; D015433:Glomerulonephritis, Membranous / Q000473:pathology / Q000821:virology*; D006509:Hepatitis B / Q000150:complications*; D006515:Hepatitis B virus / Q000254:growth & development*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D014779:Virus Replication
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone