title: Exploring the Caenorhabditis elegans and Drosophila melanogaster genomes to understand neuropeptide and peptidase function.
abstract: Comparison of peptidase gene families in the newly released Drosophila melanogaster and Caenorhabditis elegans genomes highlights important differences in peptidase distributions with relevance to the evolution of both form and function in these two organisms and can help to identify the most appropriate model when using comparative studies relevant to the human condition.
authors.affiliation: School of Biology, University of Leeds, Leeds LS2 9JT, U.K. d.coates@leeds.ac.uk
authors.forename: D
authors.initials: D
authors.lastname: Coates
authors.forename: R
authors.initials: R
authors.lastname: Siviter
authors.forename: R E
authors.initials: RE
authors.lastname: Isaac
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D016678:Genome; D007448:Invertebrates; D020782:Matrix Metalloproteinases / Q000235:genetics; D008666:Metalloendopeptidases / Q000235:genetics; D015260:Neprilysin / Q000235:genetics; D009479:Neuropeptides / Q000235:genetics / Q000502:physiology*; D010447:Peptide Hydrolases / Q000235:genetics / Q000502:physiology*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D010641:Phenotype; D010802:Phylogeny; D012697:Serine Endopeptidases / Q000235:genetics; D015032:Zinc / Q000378:metabolism
chemical_list: D009479:Neuropeptides; D010447:Peptide Hydrolases; D007703:Peptidyl-Dipeptidase A; D012697:Serine Endopeptidases; D020782:Matrix Metalloproteinases; D008666:Metalloendopeptidases; D015260:Neprilysin; D015032:Zinc