Management of hepatitis B virus infection in liver transplant recipients: prospects and challenges.
Although survival of liver transplantation for patients with hepatitis B infection is comparable to uninfected transplant recipients, prevention of hepatitis B virus (HBV) reinfection remains an important goal. In this article, several aspects of the hepatitis B reinfection and its management will be examined. Approximately 50% of the treatment failures that occur with hepatitis B immune globulin (HBIg) prophylaxis are due to mutations in the 'a' determinant of the HBV. In patients without mutations, failure of HBIg therapy may relate to the frequency and dose of HBIg, the type and amount of immunosuppression, and the pre-transplant replication status. Antiviral therapy with lamivudine and famciclovir has been used successfully to treat patients who have failed HBIg treatment and as monotherapies for liver transplant recipients. Combining antiviral and immunomodulatory therapies appears efficacious, at least in the short term. New developments related to immunotherapy predict three potential trends in future use: 1) i.v. formulated HBIg, 2) monoclonal antibodies, or 3) hepatitis B immune plasma. In conclusion, there are an increasing number of therapeutic options for the management of patients undergoing liver transplantation for hepatitis B infection. Continued improvement in patient outcomes requires further understanding of each therapeutic agent and the specific patient characteristics that may influence efficacy.
Terrault
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Division of Gastroenterology, University of California San Francisco, 94143, USA.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D006509:Hepatitis B / Q000188:drug therapy* / Q000517:prevention & control; D006515:Hepatitis B virus / Q000235:genetics / Q000254:growth & development; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy; D016031:Liver Transplantation; D009154:Mutation / Q000235:genetics; D015996:Survival Rate; D017211:Treatment Failure; D014779:Virus Replication
D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D007136:Immunoglobulins; D007166:Immunosuppressive Agents; C045213:hepatitis B hyperimmune globulin