title: Does blood type B protect against haemolytic uraemic syndrome? An analysis of the 1996 Sakai outbreak of Escherichia coli O157:H7 (VTEC O157) infection. The Osaka HUS Critical Care Study Group.
abstract: OBJECTIVE
  Expression of the P1 blood type antigen is suggested to have a protective effect against post-enteropathic haemolytic uraemic syndrome (HUS). The B blood type may also protect against HUS, since terminal trisaccharide sequences similar to those of the B blood type determinants are reported to have an affinity to Vero cytotoxin that is 23% as strong as that of the P1 determinants. Thus, we studied whether ABO blood types were related to the occurrence or severity of HUS.
  
  
  METHODS
  We obtained clinical and laboratory data of 49 HUS patients treated in 14 critical care facilities during the 1996 Escherichia coli O157:H7 outbreak in Sakai, Japan. We retrospectively studied whether ABO blood types were related to the occurrence or severity of HUS.
  
  
  RESULTS
  The numbers of patients with blood types A, B, O or AB were 29, 8, 12, and 0, respectively. For each blood type, the number of patients with severe renal complications was 16, 6, 9, and 0, respectively. The distribution of blood types among the HUS patients deviated from a population-based distribution of blood types (P<0.05, Chi-squared test); i.e., the frequency of the A blood phenotype was significantly higher among our HUS patients. However, there was no significant difference in the frequency of patients with the A antigen (A and AB blood groups) among our HUS patients, whereas the frequency of B antigen expression was significantly lower (P<0.05, Chi-squared test). The risk of severe renal complications did not appear to be related to ABO blood types.
  
  
  CONCLUSIONS
  Our data suggest that expression of the B antigen has a protective effect against the onset of HUS, but that it does not affect the severity of the disease.
authors.affiliation: Department of Traumatology and Acute Critical Medicine, Osaka University Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Shimazu
authors.forename: M
authors.initials: M
authors.lastname: Shimaoka
authors.forename: H
authors.initials: H
authors.lastname: Sugimoto
authors.forename: N
authors.initials: N
authors.lastname: Taenaka
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
mesh_terms: D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004927:Escherichia coli Infections / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D019453:Escherichia coli O157 / Q000472:pathogenicity*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D017678:Sex Distribution
chemical_list: D000017:ABO Blood-Group System