[Effectiveness of dietary non-starch polysaccharides in experimental toxic hepatitis].
The efficiency of some polysaccharides was investigated in mice with an experimental toxic hepatitis. Hepatitis was induced by the oral administration of 10% solution CCl4 in olive oil at a dosage of 3 ml/kg body weight every day during 7 days. After that tested substances were administrated every day 30-40 min before a feeding at a dosage of 150 mg/kg body weight during 14-21 days. Results showed that a calcium alginate, two low-methoxyl pectins (one with the degree of esterification about 50% and other with the degree of esterification less 5%), fucoidan, and chitozan, but not lambda-carrageenan and kappa-carrageenan, have beneficial affects on liver total lipid, glycogen, malondialdehyde, and diene conjugates as well as on blood total lipid and alanine aminotransferase activity in animals with experimental toxic hepatitis.
Khotimchenko
Iu S
IuS
Khasina
E I
EI
Kovalev
V V
VV
Shevtsova
O I
OI
Shestakova
S V
SV
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications*; D002351:Carrageenan / Q000008:administration & dosage / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000178:diet therapy* / Q000209:etiology / Q000378:metabolism; D002686:Chitin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D048271:Chitosan; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000494:pharmacology; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000178:diet therapy* / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
D004040:Dietary Carbohydrates; D008055:Lipids; D011134:Polysaccharides; D002686:Chitin; D002351:Carrageenan; D048271:Chitosan; C007789:fucoidan; D000410:Alanine Transaminase