HIV-1 subtypes in injecting drug users & their non-injecting wives in Manipur, India.
The presence of HIV-1 antibodies was determined among the injecting drug users (IDUs) and their non-injecting wives. A total of 233 (72%) were found to be HIV-1 seropositive among the 322 subjects recruited in this study between August, 1996 and September, 1997. The distribution of HIV-1 subtypes among the injecting drug users (IDUs) and their wives was determined using peptide enzyme immunoassay (EIA). Sexual transmission of HIV-1 occurred frequently (45%) from HIV-1 infected IDUs to their spouses. The majority of the subjects (167/233) were infected with subtype C followed by subtype Thai B (29/233). Subtype C was the most common among both IDUs (78%) and their wives (57%), followed by subtype Thai B (12% and 13% respectively). The distribution of subtypes was significantly different between IDUs and their wives with a lower percentage of subtype C and higher percentage of subtype D in the infected wives (P < 0.03). Discordance for subtypes transmitted from IDUs to their wives suggests the occurrence of dual and/or recombinant infection in the IDUs.
Chakrabarti
S
S
National Institute of Cholera & Enteric Diseases (ICMR), Calcutta.
Panda
S
S
Chatterjee
A
A
Sarkar
S
S
Manna
B
B
Singh
N B
NB
Naik
T N
TN
Detels
R
R
Bhattacharya
S K
SK
D005260:Female; D015483:HIV Antibodies / Q000032:analysis; D015497:HIV-1 / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007194:India; D008297:Male; D018454:Spouses; D015819:Substance Abuse, Intravenous / Q000276:immunology / Q000821:virology*
D015483:HIV Antibodies