Diesel exhaust as a model xenobiotic in allergic inflammation.
We investigated the effects of diesel exhaust particulates on the human allergic response using in vivo human nasal challenges. Diesel particles and phenanthrene, one of their constituent polyaromatic hydrocarbons, were shown to enhance total allergic antibody (IgE) production, enhance allergen-specific IgE in the presence of allergen, and induce sensitization to a neoantigen.
Saxon
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Hart and Louise Lyon Laboratory, Division of Clinical Immunology/Allergy, Department of Medicine, UCLA School of Medicine, University of California, Los Angeles, CA 951361, USA. asaxon@mednet.ucla.edu
Diaz-Sanchez
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D
D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D001335:Vehicle Emissions / Q000009:adverse effects; D015262:Xenobiotics / Q000009:adverse effects
D001335:Vehicle Emissions; D015262:Xenobiotics; D007073:Immunoglobulin E