title: Subretinal fluid levels of topical, oral, and combined administered ciprofloxacin in humans.
abstract: OBJECTIVE
  To investigate the subretinal fluid (SRF) penetration of ciprofloxacin following topical, oral, and combined administration.
  
  
  METHODS
  34 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Twelve patients received topical ciprofloxacin, 11 patients received oral ciprofloxacin, and the other 11 patients received combined drug administration. SRF drug level was measured by using high performance liquid chromatography method.
  
  
  RESULTS
  The highest drug concentrations of all tested modes were attained following combined administration and lowest following topical administration (p<0.001). The SRF drug concentration following oral administration was also significantly higher than that of topical administration (p<0.001). Concentrations after oral and combined administration did not differ significantly (p = 0.217).
  
  
  CONCLUSIONS
  Topical ciprofloxacin can penetrate SRF. Ocular bioavailability of ciprofloxacin in SRF after oral and combined administration is equivalent.
authors.affiliation: SSK Ankara Eye Hospital, Department of Vitreoretinal Surgery, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Cekiç
authors.forename: C
authors.initials: C
authors.lastname: Batman
authors.forename: U
authors.initials: U
authors.lastname: Yaşar
authors.forename: N E
authors.initials: NE
authors.lastname: Başci
authors.forename: O
authors.initials: O
authors.lastname: Zilelioğlu
authors.forename: A
authors.initials: A
authors.lastname: Bozkurt
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D012160:Retina / Q000378:metabolism*; D012163:Retinal Detachment / Q000601:surgery; D018709:Statistics, Nonparametric; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D004338:Drug Combinations; D002939:Ciprofloxacin