Treatment of adjuvant arthritis in mice with yeast superoxide dismutase.
Yeast Cu/Zn superoxide dismutase (SODy) was used for treatment of adjuvant-induced arthritis in mice. SODy was applied intraperitoneally (i.p.) in doses of 10 mg/kg (30,000 U/kg) and 30 mg/kg (90,000 U/kg) one or three times daily on consecutive days. It was very effective in reducing the paw swelling whether administered before or immediately after induction or when the treatment began at the onset of inflammation or at the peak of the arthritic process. The effect of yeast SOD was compared to that of commercial SOD from bovine erythrocytes (SODb), as well as with indomethacin treatment. Histological data confirmed the antiinflammatory effect of yeast SOD. The schedules and doses tested did not elicit anti-SOD antibodies in serum.
Ratcheva
I
I
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Stefanova
Z
Z
Vesselinova
A
A
Nikolova
S
S
Kujumdjieva
A
A
Neychev
H
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000906:Antibodies / Q000032:analysis; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D004912:Erythrocytes / Q000201:enzymology; D007213:Indomethacin / Q000627:therapeutic use; D007596:Joints / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013482:Superoxide Dismutase / Q000276:immunology / Q000627:therapeutic use*; D015003:Yeasts / Q000201:enzymology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000906:Antibodies; D013482:Superoxide Dismutase; D007213:Indomethacin