New purine derivatives for efficient preparation of nucleoside analogs via alkylation.
New diazabicycloundecenium and phosphazenium derivatives of purines are introduced for mild and efficient preparation of nucleoside analogs via in situ alkylation. Diazabicycloundecenium salts of purines were obtained directly as a result of an unusual reaction between two corresponding amino compounds.
Lukin
K A
KA
Process Development, Chemical and Agricultural Products Division, Abbott Laboratories, North Chicago, IL 60064-6291, USA.
Yang
C X
CX
Bellettini
J R
JR
Narayanan
B A
BA
D000478:Alkylation; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D055598:Chemical Phenomena; D002621:Chemistry; D009705:Nucleosides / Q000138:chemical synthesis*; D011687:Purines / Q000138:chemical synthesis
D001372:Aza Compounds; D009705:Nucleosides; D011687:Purines