title: Squamous cell carcinoma arising in recurrent respiratory papillomatosis with pulmonary involvement: emerging common pattern of clinical features and human papillomavirus serotype association.
abstract: Squamous papillomas of the lung are an uncommon feature of recurrent respiratory papillomatosis, occurring in fewer than 1% of cases. We describe a 23-year-old patient with pulmonary papillomas who developed a fatal squamous cell carcinoma of the lung. PCR-based human papillomavirus (HPV) typing showed the presence of HPV 11 DNA in both benign papillomas and invasive carcinoma. A review of the literature reveals four reports of malignant transformation of juvenile-onset recurrent respiratory papillomatosis in which HPV typing was performed. Similar clinical features are noted in all of the reports; specifically, each case has arisen in a young adult man with a history of papillomatosis since childhood. In each of the cases, HPV 11 was identified in association with the squamous cell carcinoma. Although HPV 11 is uncommonly associated with the development of invasive carcinoma at other sites, these findings suggest that it is correlated with malignant transformation in the setting of juvenile-onset recurrent respiratory papillomatosis.
authors.affiliation: Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Pathology, Washington University School of Medicine, St. Louis, Missouri, USA. jcook@path.wustl.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Cook
authors.forename: D A
authors.initials: DA
authors.lastname: Hill
authors.forename: P A
authors.initials: PA
authors.lastname: Humphrey
authors.forename: J D
authors.initials: JD
authors.lastname: Pfeifer
authors.forename: S K
authors.initials: SK
authors.lastname: El-Mofty
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D017931:DNA Primers / Q000737:chemistry; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000821:virology; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000821:virology; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000821:virology; D010212:Papilloma / Q000473:pathology* / Q000821:virology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology*
chemical_list: D017931:DNA Primers; D004279:DNA, Viral