Gene therapy approaches for modulating bone regeneration.
Following injury, bone has the ability to regenerate itself to a form and function nearly indistinguishable from the pre-injury state. However, if the injury is beyond a critical limit, recovery will not occur without therapeutic interventions. Autografts and implants with banked bone continue as the treatments of choice, although each exhibits limitations and liabilities. Alternatives have included the utilization of bone-graft substitutes that may incorporate bone derivatives and soluble signaling molecules such as mitogens and morphogens. In addition, an evolving treatment modality, gene therapy, offers an exciting avenue for bone regeneration. This review presents some of the current concepts for developing a rational gene therapy approach in bone regeneration.
Winn
S R
SR
Department of Surgery, School of Medicine, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA. winns@ohsu.edu
Hu
Y
Y
Sfeir
C
C
Hollinger
J O
JO
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use; D001861:Bone Regeneration; D016207:Cytokines / Q000627:therapeutic use; D050723:Fractures, Bone / Q000628:therapy; D018390:Gene Targeting; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans
D019485:Bone Morphogenetic Proteins; D016207:Cytokines