Identification of novel polymorphisms in the AXIN1++ and CDX-2 genes.
Axin and Cdx-2 play important roles in the tumorigenesis of human liver and colon. We have identified seven novel single-nucleotide polymorphisms (SNPs) in the AXIN1 gene and three in the CDX-2 gene. The identification of SNPs in these cancer-associated genes establishes a basis for future investigations to detect losses of heterozygosity in tumors; these SNPs may also provide genetic background information associated with cancer risk.
Lin
Y M
YM
Laboratory of Molecular Medicine, University of Tokyo, Japan.
Kato
T
T
Satoh
S
S
Nakamura
Y
Y
Furukawa
Y
Y
D000483:Alleles; D060466:Axin Protein; D000071616:CDX2 Transcription Factor; D004252:DNA Mutational Analysis; D005091:Exons; D016147:Genes, Tumor Suppressor; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007564:Japan; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012097:Repressor Proteins; D015534:Trans-Activators
C555451:AXIN1 protein, human; D060466:Axin Protein; D000071616:CDX2 Transcription Factor; D018398:Homeodomain Proteins; D011506:Proteins; D012097:Repressor Proteins; D015534:Trans-Activators