[Comparison of cathepsin-B-like activity and CA 125 assays use in ovarian cancer diagnosis].
BACKGROUND
Determination of serum cathepsin B-like activity was used as a diagnostic marker of ovarian cancer. The aim of this study was to compare its diagnostic utility with CA 125 assay.


METHODS
In 50 patients with epithelial ovarian cancer and 20 with ovarian cyst cathepsin B-like activity by fluorimety and CA 125 concentration by luminiscence immunoassay, were determined. The obtained results were compared by two cut-off values computed from the data obtained in healthy controls and ovarian cysts (cathepsin B: 11 and 108 mU/ml; CA 125: 35 and 135 U/ml), respectively.


RESULTS
In differential diagnosis between ovarian carcinomas and ovarian cysts cathepsin B shows similar specificity (95%) as CA 125 but higher sensitivity (63.5% vs 50%). Both cathepsin B and CA 125 are good predictors of tumour response and recurrence


CONCLUSIONS
Adding CA 125 determination to cathepsin B-like activity in the laboratory diagnostics of ovarian cancer increased the sensitivity and positive predictive values as compared to the use of cathepsin B alone.
Warwas
M
M
Katedry i Zakładu Biochemii Farmaceutycznej AM we Wrocławiu.
Gerber
J
J
Haczyńska
H
H
Lukasik-Lemańska
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000378:metabolism*; D002401:Cathepsin B / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism*; D011237:Predictive Value of Tests
D018394:CA-125 Antigen; D002401:Cathepsin B