Protection against snake venom-induced neuronal injury by the new hypothalamic neurohormone.
The action of PRP is characterized by the pronounced activation of the background activity (BA) of the brain spinal cord, and the degree of the activity depends on BA initial level. The typical peculiarity of Vipera raddei venom influence is the initial increase in frequency of BA with subsequent depression. A preliminary injection of PRP has a protective effect at subsequent influence of venom. In animals with hemisection the PRP increases the decreased activity of neurons on injury side. Taking into consideration the protective peculiarities of PRP in the relationship to snake venom and the possibility of the latter to stabilize and prolong the action of drugs (in the case of PRP) combined with them, it is supposed that the mentioned use of the combination in clinical practice will be perspective. The data obtained testify the PRP to be a neuroprotector against many toxic compounds formed in organism (glutamate, ceramid, beta-amyloid neurotoxisity, etc.). Investigations in this aspect are still in the process.
Galoyan
A A
AA
Buniatian Institute of Biochemistry NAS RA, Yerevan, The Republic of Armenia. galoyan@sci.am
Kipriyan
T K
TK
Sarkissian
J S
JS
Sarkissian
E J
EJ
Grigorian
Y K
YK
Andreasian
A S
AS
Chavushyan
E A
EA
D000595:Amino Acid Sequence; D000818:Animals; D007028:Hypothalamic Hormones / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D008969:Molecular Sequence Data; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D011392:Proline / Q000737:chemistry*; D055232:Proline-Rich Protein Domains; D051381:Rats; D012910:Snake Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology
D007028:Hypothalamic Hormones; D018696:Neuroprotective Agents; D010455:Peptides; D012910:Snake Venoms; D011392:Proline