Effects of alcohol on the acoustic reflex threshold in the chinchilla.
The effect of ethanol on the acoustic reflex threshold was examined in a repeated measure design study in six chinchillas. Each subject was weighed and orally administered the control (water) at a dosage of 7.5 ml/kg. Commencing 1 h after alcohol ingestion, the acoustic middle ear reflex measures (AMRs) were taken every other hour, for a total of four recording sessions. Ascending and descending trials were alternated between each recording session. Two weeks later the same chinchillas were administered 35% alcohol by volume. AMRs were recorded under the same conditions and procedures as for the control. Alcohol produced AMRs that were significantly elevated over baseline values 1 h after alcohol ingestion and four of the five had AMRs that remained elevated 3 h after ingestion.
Uhles
M L
ML
Department of Psychology, St Louis University, Missouri, USA. uhlesm@neuro.uustl.edu
Clark
W W
WW
Anch
M
M
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D002682:Chinchilla; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008297:Male; D012022:Reflex, Acoustic / Q000187:drug effects*
D000431:Ethanol