Cardiovascular effects of an intravenous bolus of morphine in the ventilated preterm infant.
OBJECTIVE
To examine the cardiovascular effects of an intravenous bolus of morphine, 100 microg/kg, in 17 ventilated preterm infants.


METHODS
Heart rate and blood pressure were monitored. Right ventricular output, superior vena caval flow, and the width of the ductus arteriosus were measured by Doppler echocardiography 10 and 60 minutes after the morphine injection, and the values compared with baseline values by the paired t test.


RESULTS
There was a small but significant fall in heart rate (2.1% at 10 minutes, 4.3% at 60 minutes) consistent with a sedative effect. There was no effect on systolic, diastolic, or mean blood pressure. There was no significant effect on systemic blood flow as measured by either right ventricular output or superior vena caval flow. Ductal width was significantly reduced by a mean of 16% at 60 minutes, suggesting that normal duct closure was not inhibited.


CONCLUSIONS
No cardiovascular effects of an intravenous bolus of morphine could be detected.
Rutter
N
N
Division of Child Health, School of Human Development, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK. Nick.Rutter@nottingham.ac.uk
Evans
N
N
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D001775:Blood Circulation / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004373:Ductus Arteriosus / Q000000981:diagnostic imaging / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007275:Injections, Intravenous; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D012121:Respiration, Artificial / Q000379:methods*; D014463:Ultrasonography
D000701:Analgesics, Opioid; D009020:Morphine