C-Difluoromethylene-containing, C-trifluoromethyl and C-perfluoroalkyl carbohydrates. Synthesis by carbohydrate transformation or building block methods.
The synthetic methods for preparing carbohydrates bearing a C-branched substituent of the type CF2-Y, with Y = F, Y = CnF(2n + 1) or Y = a carbon-attached or heteroatom-attached nonfluorinated residues, are reviewed. Both direct introduction of C-branched fluorinated substituents (direct trifluoromethylation, perfluoroalkylation or difluoromethylenation) and building block methods from fluorinated synthons are considered.
Plantier-Royon
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R
Laboratoire Réactions Sélectives et Applications, Associé au CNRS (UMR 6519), Université de Reims, Facult des Sciences, France.
Portella
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C
D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D005466:Fluorocarbons / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure
D002241:Carbohydrates; D005466:Fluorocarbons; D005461:Fluorine