Hereditary intestinal cancer.
Mechanisms involved in hereditary intestinal cancer are likely to play a role in sporadic tumorigenesis as well. Studies focusing on the molecular biology underlying these syndromes has contributed considerably to our knowledge on molecular bases of malignant transformation. It can be concluded, that there are two aspects to the importance of studies on intestinal cancer predisposition. First, the families suffering from cancer proneness need help which can, to some extent, be provided through molecular genetic studies. Second, the resources appointed to such research have produced scientific advances with outstanding importance to our understanding of common malignant diseases.
Aaltonen
L A
LA
Department of Medical Genetics, University of Helsinki, P.O. Box 21, FIN-00014, Finland.
D011125:Adenomatous Polyposis Coli / Q000150:complications / Q000235:genetics; D000328:Adult; D000367:Age Factors; D015179:Colorectal Neoplasms / Q000209:etiology / Q000517:prevention & control; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008875:Middle Aged; D010580:Peutz-Jeghers Syndrome / Q000150:complications / Q000175:diagnosis; D012307:Risk Factors