A brief history of the randomized controlled trial. From oranges and lemons to the gold standard.
This article discusses the history and development of randomized clinical trial methodology, the reasons for its status and authority as a method of therapeutic evaluation, and the continuing role of clinical judgement in designing, interpreting, and applying the findings of trials.
Meldrum
M L
ML
Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000266:history / Q000331:legislation & jurisprudence / Q000379:methods; D004341:Drug Evaluation / Q000266:history / Q000331:legislation & jurisprudence / Q000379:methods; D005060:Europe; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D011057:Politics; D011639:Public Opinion; D016032:Randomized Controlled Trials as Topic / Q000266:history* / Q000331:legislation & jurisprudence / Q000379:methods; D012107:Research Design; D014342:Truth Disclosure; D014481:United States; D014492:United States Public Health Service / Q000266:history
D000900:Anti-Bacterial Agents