Synthesis and evaluation of quinoline carboxyguanidines as antidiabetic agents.
The synthesis and in vivo activities of a series of substituted quinoline carboxyguanidines as a possible novel class of antidiabetic agents is described.
Edmont
D
D
Institut de Chimie Organique et Analytique, Université d'Orleans, France.
Rocher
R
R
Plisson
C
C
Chenault
J
J
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006146:Guanidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D006146:Guanidines; D007004:Hypoglycemic Agents; D011804:Quinolines