Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir.
Hemorrhagic cystitis (HC) is a common complication following high-dose chemotherapy and bone marrow transplantation, and the treatment of virus-associated HC remains to be optimized. This is the first report on the successful use of cidofovir in a patient with HC and polyoma viruria concomitant with CMV reactivation after allogeneic BMT. Treatment led to a significant decrease in viruria and to sustained suppression of CMV reactivation. Administered with probenecid and hydration, cidofovir was well tolerated, and there were no side-effects.
Held
T K
TK
Klinik für Innere Medizin mit Schwerpunkt Hämatologie und Onkologie, Charité/Campus Virchow-Klinikum, Berlin, Germany.
Biel
S S
SS
Nitsche
A
A
Kurth
A
A
Chen
S
S
Gelderblom
H R
HR
Siegert
W
W
D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus; D000077404:Cidofovir; D003556:Cystitis / Q000188:drug therapy* / Q000821:virology; D003587:Cytomegalovirus / Q000254:growth & development*; D003586:Cytomegalovirus Infections / Q000097:blood / Q000188:drug therapy / Q000652:urine / Q000821:virology*; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006417:Hematuria / Q000209:etiology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D030361:Papillomavirus Infections / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D014775:Virus Activation / Q000187:drug effects
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir