title: The role of gamma knife surgery in the treatment of severe epilepsies.
abstract: There is a strong rationale for investigation of the role of gamma knife radiosurgery in the treatment of medically intractable epilepsy. To explore this potential application, the current outcome and morbidity associated with established microsurgical treatment, as well as the associated advantages and disadvantages of open surgery, are reviewed. The preliminary evidence in support of radiosurgical treatment and the recent experience with gamma knife treatment for epilepsy associated with mesial temporal sclerosis, cavernous angioma, and hypothalamic hamartoma or other lesions are presented. The strengths and limitations of this application are discussed, and the challenges facing both microsurgical and radiosurgical approaches are considered. Gamma knife surgery can be a main approach among others in the armamentarium of epilepsy surgery. Although the benefits of comfort and reduced invasivity can be clearly perceived, larger series and long-term follow up are still required in order to evaluate the future of this particular surgical approach.
authors.affiliation: Stereotactic and Functional Neurosurgery Department, Timone Hospital, Marseille, France. jregis@ap-hm.fr
authors.forename: J
authors.initials: J
authors.lastname: Régis
authors.forename: F
authors.initials: F
authors.lastname: Bartolomei
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: D
authors.initials: D
authors.lastname: Roberts
authors.forename: P
authors.initials: P
authors.lastname: Chauvel
authors.forename: J C
authors.initials: JC
authors.lastname: Peragut
mesh_terms: D004827:Epilepsy / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008866:Microsurgery; D019635:Neurosurgical Procedures; D016634:Radiosurgery / Q000379:methods*; D012720:Severity of Illness Index; D016896:Treatment Outcome