Voltage-gated potassium channels in human ductus arteriosus.
We studied tone in the human ductus arteriosus and show that the constriction to oxygen is due to inhibition of voltage-gated potassium channels and, in the acute phase, is independent of endothelin-1.
Michelakis
E
E
Rebeyka
I
I
Bateson
J
J
Olley
P
P
Puttagunta
L
L
Archer
S
S
D015761:4-Aminopyridine / Q000494:pharmacology; D018999:Charybdotoxin / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004373:Ductus Arteriosus / Q000648:ultrastructure*; D004374:Ductus Arteriosus, Patent / Q000378:metabolism*; D019332:Endothelin-1 / Q000187:drug effects / Q000502:physiology*; D005905:Glyburide / Q000494:pharmacology; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*
D016861:Cyclooxygenase Inhibitors; D019332:Endothelin-1; D015221:Potassium Channels; D018999:Charybdotoxin; D015761:4-Aminopyridine; D019001:Nitric Oxide Synthase; D005905:Glyburide