Argifin, a new chitinase inhibitor, produced by Gliocladium sp. FTD-0668. I. Taxonomy, fermentation, and biological activities.
A new chitinase inhibitor, named argifin, was isolated from the cultured broth of a fungal strain FTD-0668. The strain was identified as Gliocladium sp. from morphological characteristics. The IC50 value of argifin against Lucilia cuprina chitinase was 3.7 microM. Argifin arrested the moult of cockroach larvae upon injection into the ventral abdominal part.
Omura
S
S
Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.
Arai
N
N
Yamaguchi
Y
Y
Masuma
R
R
Iwai
Y
Y
Namikoshi
M
M
Turberg
A
A
Kölbl
H
H
Shiomi
K
K
D000818:Animals; D001419:Bacteria / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line / Q000187:drug effects; D002688:Chitinases / Q000037:antagonists & inhibitors*; D003058:Cockroaches / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007814:Larva / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000145:classification / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000378:metabolism* / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; C413566:argifin; D002688:Chitinases