title: Prevalence of HIV among pregnant women in Dundee 1988-1997: evidence to gauge the effectiveness of HIV prevention measures.
abstract: OBJECTIVE
  During November 1988-July 1990, an HIV prevalence survey of pregnant women in Dundee, which used a combined voluntary diagnostic testing and voluntary unlinked anonymous approach, revealed a rate of 0.3%, the highest recorded prevalence among such a population in the U.K. at the time. To determine if, and why, any changes in HIV prevalence had occurred during the early to mid 1990s, further studies were conducted.
  
  
  METHODS
  During January 1993-December 1997, antenatal patients of, and women undergoing therapeutic termination of pregnancy at, Ninewells Hospital, Dundee, were offered a diagnostic HIV antibody test. For those declining, residual sera from rubella specimens were tested for HIV antibodies using an unlinked anonymous approach which did not necessitate the securement of informed consent. Information about injecting drug use was obtained from all women and linked to their HIV test results.
  
  
  RESULTS
  For all pregnant women, a significant decline in HIV prevalence (P<0.05) from 0.3% (19/6228) during 1988-1990 to 0.12% (22/17899) during 1993-1997 was observed. For those who injected drugs, prevalence decreased significantly (P<0.05) from 27.5% (11/40) to 7% (6/85), while among women who had never injected drugs prevalence decreased slightly, but not significantly (P>0.05), from 0.13% (8/6188) to 0.09% (16/17814).Prevalence in the non-injectors who reported no sexual intercourse with an injector was low at 0.04% (8/17682) during 1993-1997. No significant trends in HIV prevalence were seen over the 5 years up to 1997.
  
  
  CONCLUSIONS
  The decline in HIV prevalence among pregnant women in Dundee during the early to mid-1990s can be explained predominantly by the control of HIV transmission among the city's injectors, and from them to the wider heterosexual population. It is likely that interventions designed to reduce needle/syringe sharing among injectors have been successful. It is imperative that the preventive effort is not allowed to be weakened.
authors.affiliation: Scottish Centre for Infection and Environmental Health, Ruchill Hospital, Glasgow, UK.
authors.forename: D
authors.initials: D
authors.lastname: Goldberg
authors.forename: R
authors.initials: R
authors.lastname: Smith
authors.forename: P
authors.initials: P
authors.lastname: MacIntyre
authors.forename: N
authors.initials: N
authors.lastname: Patel
authors.forename: M
authors.initials: M
authors.lastname: Rowarth
authors.forename: G
authors.initials: G
authors.lastname: Allardice
authors.forename: G
authors.initials: G
authors.lastname: Codere
authors.forename: D
authors.initials: D
authors.lastname: Reid
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000372:Agglutination Tests; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D015995:Prevalence; D012606:Scotland / Q000453:epidemiology; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000276:immunology
chemical_list: D015483:HIV Antibodies