Sequential analysis of HLA-C-specific killer cell inhibitory receptor (CD158b) expressing peripheral blood mononuclear cells during chronic graft-versus-host disease.
We have sequentially investigated the expression of natural killer cell inhibitory receptors (KIRs) for HLA-C (CD158b) on peripheral blood mononuclear cells (PBMC) in three patients with extensive chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplantation (alloBMT). Clinical symptoms of cGVHD were not cured and worsened in the first patient whose CD158b-positive cells increased to 18.5% during cGVHD and decreased to 9.4% at 8 months after transplantation. On the other hand, cGVHD was cured and did not relapse in the second patient whose CD158b-positive cells increased up to 45.9% during cGVHD and sustained 19.4% at 8 months after transplantation. In contrast, CD158b-positive cells were less than 10% during the course of cGVHD in the third patient, and her cGVHD did not respond to treatment. Therefore, it appears that chronic allostimulation augments the expansion of CD158b-positive cells and these expanded CD158b-positive cells may have some role in the control of alloresponse in some patients.
Tanaka
J
J
Department of Hematology and Oncology, Hokkaido University School of Medicine, Sapporo, Japan.
Tutumi
Y
Y
Mori
A
A
Ohta
S
S
Kobayashi
S
S
Asaka
M
M
Imamura
M
M
D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002908:Chronic Disease; D000939:Epitopes / Q000097:blood / Q000276:immunology; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood / Q000276:immunology*; D015236:HLA-C Antigens / Q000097:blood / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D008297:Male; D011971:Receptors, Immunologic / Q000096:biosynthesis* / Q000097:blood / Q000276:immunology; D054340:Receptors, KIR; D054344:Receptors, KIR2DL3
D000939:Epitopes; D015236:HLA-C Antigens; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054344:Receptors, KIR2DL3