Lymphocyte-endothelial cell adhesive interactions in lung immunity: lessons from the murine response to particulate antigen.
The adhesive interaction between lymphocytes and lung endothelial cells presents an attractive arena for the development of novel therapeutic agents to modify pathologic pulmonary immune responses. The conceptual basis for choosing molecular targets to modulate this adhesive interaction derives, in large part, from results of murine experimental model systems of the pulmonary immune response. This article reviews one such model, the response of primed C57BL/6 mice to the particulate antigen sheep erythrocytes. Novel data are presented on the effect of a blocking anti-alpha(4) integrin monoclonal antibody on lung leukocyte and lymphocyte subset accumulation after intratracheal (IT) antigen challenge. Results from this model system have indicated that lymphocytes may use either the endothelial selectins or alpha(4) integrin as independent pathways to initiate recruitment into the lungs.
Curtis
J L
JL
Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48105, USA. jlcurtis@unich.edu
Wolber
F M
FM
Sonstein
J
J
Craig
R A
RA
Polak
T
T
Knibbs
R N
RN
Todt
J
J
Seitzman
G D
GD
Stoolman
L M
LM
D000818:Animals; D000941:Antigens / Q000276:immunology; D015703:Antigens, CD / Q000378:metabolism*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism; D004727:Endothelium / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D039441:Integrin alpha4; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D051379:Mice; D011014:Pneumonia / Q000276:immunology* / Q000378:metabolism; D019087:Selectins / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000941:Antigens; D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D019087:Selectins; D039441:Integrin alpha4