title: Suprasellar germinoma in three lake whitefish (Coregonus clupeaformis).
abstract: Suprasellar germinomas were identified in three wild-caught lake whitefish (Coregonus clupeaformis) from the St. Lawrence River, Quebec, Canada. Histologically, the three tumors expanded the subarachnoid space of the ventral surface of the brain immediately adjacent to the pituitary gland and, in one case, infiltrated the adjacent neuropil. These tumors were characterized by nests and sheets of round cells with a high mitotic rate, separated by a scant amount of loose fibrovascular stroma. The stroma was infiltrated by a moderate number of small mononuclear cells, including rare CD3-immunoreactive lymphocytes. This is the first report of intracranial germinoma in a fish species.
authors.affiliation: Canadian Cooperative Wildfire Health Centre and Centre Québécois sur la Santé des Animaux Sauvages, Département de Pathologie et de Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec.
authors.forename: I
authors.initials: I
authors.lastname: Mikaelian
authors.forename: J M
authors.initials: JM
authors.lastname: Lapointe
authors.forename: Y
authors.initials: Y
authors.lastname: de Lafontaine
authors.forename: J C
authors.initials: JC
authors.lastname: Harshbarger
authors.forename: R J
authors.initials: RJ
authors.lastname: Côté
authors.forename: D K
authors.initials: DK
authors.lastname: Naydan
authors.forename: D
authors.initials: D
authors.lastname: Martineau
mesh_terms: D000820:Animal Diseases / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000473:pathology*; D005399:Fishes; D018237:Germinoma / Q000473:pathology / Q000662:veterinary*; D012658:Sella Turcica; D019292:Skull Base Neoplasms / Q000473:pathology / Q000662:veterinary*