title: Fas ligand and Bax gene transcription contributes to Ro60 ribonucleoprotein redistribution in UV-A irradiated human keratinocytes.
abstract: OBJECTIVE
  Ro ribonucleoproteins are of particular interest because they are serologic markers of photosensitive variants of lupus such as the subacute cutaneous lupus erythematosus (SCLE), in which the polycyclic skin lesions are triggered by exposure to the sun. We study the role of apoptosis in the expression of Ro antigen.
  
  
  METHODS
  We used UV-A irradiated keratinocytes.
  
  
  RESULTS
  We demonstrate in cultured human UVA-irradiated keratinocytes that the enhanced expression of Ro60 ribonucleoprotein is caused by antigenic redistribution consecutive to Fas-L and Bax gene activation.
authors.affiliation: Department of Immunology, CBE, Universidad Autónoma de Zacatecas, Guadelupe, Mexico.
authors.forename: J J
authors.initials: JJ
authors.lastname: Bollain-y-Goytia
authors.forename: E
authors.initials: E
authors.lastname: Avalos-Díaz
authors.forename: R
authors.initials: R
authors.lastname: Herrera-Esparza
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D001324:Autoantigens / Q000378:metabolism* / Q000528:radiation effects; D015153:Blotting, Western; D002478:Cells, Cultured; D053222:Fas Ligand Protein; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017403:In Situ Hybridization; D015603:Keratinocytes / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000378:metabolism* / Q000528:radiation effects; D014158:Transcription, Genetic; D014466:Ultraviolet Rays; D051028:bcl-2-Associated X Protein; D000099207:SS-A Antigen
chemical_list: D001324:Autoantigens; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D051028:bcl-2-Associated X Protein; C494826:BAX protein, human; C505661:FASLG protein, human; C116006:RO60 protein, human; D000099207:SS-A Antigen