Giant cell arteritis and polymyalgia rheumatica: role of viral infections.
We performed a multicenter case-control study on incident cases of giant cell arteritis and polymyalgia, and tested for viruses known to induce multinucleated giant cells in human pathology. IgM directed against Human parainfluenza type 1 virus were shown to be significantly associated with the onset of the disease in 40% of the cases, versus 20% of the controls.
Duhaut
P
P
Department of Internal Medicine, Edouard Herriot Hospital, Lyon, France. pierre.duhaut@infonie.fr
Bosshard
S
S
Dumontet
C
C
D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D005602:France / Q000453:epidemiology; D013700:Giant Cell Arteritis / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D015994:Incidence; D010222:Parainfluenza Virus 1, Human; D011111:Polymyalgia Rheumatica / Q000453:epidemiology* / Q000821:virology*; D010253:Respirovirus Infections / Q000453:epidemiology* / Q000276:immunology; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral