Association study of a functional serotonin transporter gene polymorphism with schizophrenia, psychopathology and clozapine response.
Serotonin is implicated in the pathogenesis of schizophrenia. Following serotonin release, the serotonin transporter (5-HTT) is the major determinant of serotonin inactivation. The present study tested the hypothesis that a biallelic polymorphism in the 5' regulatory region of the 5-HTT gene (5-HTTLPR) confers susceptibility to schizophrenia, association with the clinical manifestations of schizophrenia or clozapine response. 90 treatment-resistant schizophrenic patients were assessed using the Brief Psychiatric Rating Scale before and after clozapine treatment. The results demonstrated that the 5-HTTLPR variants did not play a major role in the susceptibility, clinical manifestations or clozapine response in schizophrenia.
Tsai
S J
SJ
Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan.
Hong
C J
CJ
Yu
Y W
YW
Lin
C H
CH
Song
H L
HL
Lai
H C
HC
Yang
K H
KH
D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D010054:Brief Psychiatric Rating Scale; D002352:Carrier Proteins / Q000235:genetics*; D003024:Clozapine / Q000627:therapeutic use*; D017931:DNA Primers / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics*; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D002352:Carrier Proteins; D017931:DNA Primers; D003024:Clozapine