Molecular biology of Streptococcus pneumoniae: an everlasting challenge.
Streptococcus pneumoniae is a model for elucidating: 1) recombination steps of DNA, from its discovery to polarity of integration; 2) long-patch mismatch repair, short-patch repair triggered by A/G and exclusion of deletions; 3) resistance to beta-lactam antibiotics; and 4) factors of virulence. Several of these topics remain a challenge for future investigations.
Sicard
M
M
Laboratoire de microbiologie et de génétique moléculaire du C.N.R.S. et Université Paul Sabatier, Toulouse, France. sicard@ibcg.biotoul.fr
Gasc
A M
AM
Giammarinaro
P
P
Lefrançois
J
J
Pasta
F
F
Samrakandi
M
M
D000818:Animals; D020137:Base Pair Mismatch; D004260:DNA Repair; D051379:Mice; D008957:Models, Genetic; D011008:Pneumococcal Infections / Q000382:microbiology*; D011995:Recombination, Genetic; D013296:Streptococcus pneumoniae / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence; D018440:beta-Lactam Resistance