Cl(-) secretion in colonic epithelial cells induced by the vibrio parahaemolyticus hemolytic toxin related to thermostable direct hemolysin.
A hemolytic toxin related to thermostable direct hemolysin (TDH), TDH-related hemolysin (TRH), produced by Kanagawa-phenomenon-negative Vibrio parahaemolyticus is suspected of playing an important, but yet-to-be-elucidated role in diarrhea caused by this organism. In cultured human colonic epithelial cells, TRH increases Cl(-) secretion, followed by elevation of intracellular calcium.
Takahashi
A
A
Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871, 770-8503, Japan. akiratak@biken.osaka-u.ac.jp
Kenjyo
N
N
Imura
K
K
Myonsun
Y
Y
Honda
T
T
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology; D018938:Caco-2 Cells; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000187:drug effects; D006460:Hemolysin Proteins / Q000633:toxicity*; D006801:Humans; D014736:Vibrio parahaemolyticus / Q000472:pathogenicity*
C505032:CFTR protein, human; D002712:Chlorides; D006460:Hemolysin Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D002118:Calcium