Practical ruthenium/lipase-catalyzed asymmetric transformations of ketones and enol acetates to chiral acetates.
Ketones were asymmetrically transformed to chiral acetates by one-pot processes using a lipase and an achiral ruthenium complex under 1 atm of hydrogen gas in ethyl acetate. Molecular hydrogen was also effective for the transformation of enol acetates to chiral acetates without additional acyl donors with the same catalyst system.
Jung
H M
HM
Department of Chemistry, Division of Molecular & Life Science, Pohang University of Science and Technology (POSTECH), San 31 Hyoja Dong, Pohang 790-784, Korea.
Koh
J H
JH
Kim
M J
MJ
Park
J
J
D000085:Acetates / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D007536:Isomerism; D007659:Ketones / Q000737:chemistry*; D008049:Lipase; D012428:Ruthenium; D013329:Structure-Activity Relationship
D000085:Acetates; D007202:Indicators and Reagents; D007659:Ketones; C007650:ethyl acetate; D012428:Ruthenium; D008049:Lipase