Biotransformation of a C-glycosylflavone, abrusin 2''-O-beta-D-apioside, by human intestinal bacteria.
After anaerobic incubation of abrusin 2''-O-beta-D-apioside (1) with a human fecal suspension, five metabolites were isolated and identified as abrusin (2), 1-(2',6'-dihydroxy-3',4'-dimethoxyphenyl)-3-(4''-hydroxyphenyl)propan-1- one (5), 5,6-dimethoxybenzene-1,3-diol (6), 3-(4'-hydroxyphenyl)propionic acid (7) and 3-phenylpropionic acid (8). However, methyl ether derivatives of abrusin (4'-O-methylabrusin and 4'-O-, 5-O-dimethylabrusin) resisted degradation under the same conditions.
Li
Y
Y
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
Meselhy
M R
MR
Wang
L Q
LQ
Ma
C M
CM
Nakamura
N
N
Hattori
M
M
D001711:Biotransformation; D005419:Flavonoids / Q000493:pharmacokinetics*; D006027:Glycosides / Q000493:pharmacokinetics*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D013058:Mass Spectrometry / Q000379:methods
D005419:Flavonoids; D006027:Glycosides; C417233:abrusin 2''-O-apioside