The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function.
1. This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/Cl(-)-dependent noradrenaline transporter (hNAT) and its gene. 2. Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.
Bönisch
H
H
Institute of Pharmacology & Toxicology, University of Bonn, Germany.
Runkel
F
F
Roubert
C
C
Giros
B
B
Brüss
M
M
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D003891:Desipramine / Q000494:pharmacology; D006801:Humans; D020125:Mutation, Missense / Q000235:genetics; D018377:Neurotransmitter Agents / Q000378:metabolism*; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011110:Polymorphism, Genetic / Q000235:genetics; D027981:Symporters
D018759:Adrenergic Uptake Inhibitors; D015306:Biogenic Monoamines; D002352:Carrier Proteins; D018377:Neurotransmitter Agents; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters; D003891:Desipramine