title: [Oxidative determination of hydroxyamphetamine in drops using flow injection analysis].
abstract: A flow injection-spectrophotometric determination at 540 nm of hydroxyamphetamine is reported. The procedure is based on a coloured reaction with 2-hydrazono-3-methylbenzothiazole (MBTH) and ceric ammonium nitrate (CeIV) as the oxidation reagent. Under optimised conditions, the determination of hydroxyamphetamine is achieved in a range of 0.01-0.2 mmol.l-1 with a relative standard deviation of 0.78% for 0.05 mmol.l-1 (n = 10) and a sample throughput of 75.h-1. The method was used for the determination of medicinal drug in the mass-produced dosage form of Czech origin: Pedrolon drops, Galena a.c.
authors.affiliation: Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
authors.forename: J
authors.initials: J
authors.lastname: Dolejsová
authors.forename: R
authors.initials: R
authors.lastname: Karlícek
authors.forename: M
authors.initials: M
authors.lastname: Pospísilová
mesh_terms: D017022:Flow Injection Analysis / Q000379:methods*; D016877:Oxidants; D019999:Pharmaceutical Solutions / Q000737:chemistry*; D010136:p-Hydroxyamphetamine / Q000032:analysis*
chemical_list: D016877:Oxidants; D019999:Pharmaceutical Solutions; D010136:p-Hydroxyamphetamine