Iodocyclization of O-(3-Cyclohexenyl)thiocarbamidates. An unexpected approach to vicinal cis-aminocyclohexenols
An unprecedented and unexpected iodocyclization of O-(3-cyclohexenyl)thiocarbamidates 2a-c to diiodides 7a-c, followed by alkaline hydrolysis and iodide elimination, has uncovered an alternative approach to vicinal cis-aminocyclohexenols 10a-c and 11a-c. This represents a new approach to these interesting building blocks.
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Universitat de Barcelona, Facultat de Farmacia, Unitat de Quimica Farmaceutica, Avgda. Joan XXIII, s/n, 08028 Barcelona, Spain, Departament de Quimica Organica Biologica, Institut d'Investigacions, Quimiques i Ambientals de B.
Llebaria
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Molins
E
Miravitllesc
C
Delgado
A