title: Percutaneous electrocatheter technique for on-line detection of healed transmural myocardial infarction.
abstract: Healed myocardial infarction has been recognized by its particular tissue electrical impedance spectrum measured with intramural needle electrodes in animal models. The aim of this study was to develop a percutaneous approach for in vivo recognition of areas of healed myocardial infarction by measuring myocardial electrical impedance with an intracavitary contact electrocatheter. Electrical impedance (resistance and phase angle) of normal myocardium and of a 2-month-old anterior transmural infarction were measured in nine chloralose anesthetized pigs by applying alternating currents from 1 kHz to 1 MHZ between a bipolar intracavitary catheter and a reference electrode placed on the epicardium (group I, n = 4) or on the precordium (group II, n = 5). Resistance of the infarcted myocardium was lower than that of healthy tissue at all current frequencies (ANOVA, P < 0.001) (i.e., at 1 kHz: 15 +/- 4 omega vs 50 +/- 19 omega in group I, and 64 +/- 13 omega vs 76 +/- 13 omega in group II). Phase angle at 316 kHz best differentiated transmural infarction from normal tissue (group I: -2.5 +/- 1.9 degrees vs -14.8 +/- 4.6 degrees, P < 0.001; group II: +0.7 +/- 1.0 degrees vs -2.7 +/- 1.4 degrees, P < 0.001). This study shows that analysis of myocardial impedance spectrum using a percutaneous intracavitary contact catheter approach permits on-line recognition of areas of healed transmural myocardial infarction. This technique may be useful to optimize clinical application of energy sources (i.e., radiofrequency ablation, laser myocardial revascularization).
authors.affiliation: Experimental Cardiology Laboratory, Hospital Vall d'Hebron, Autonomous University of Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Warren
authors.forename: R
authors.initials: R
authors.lastname: Bragós
authors.forename: O
authors.initials: O
authors.lastname: Casas
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Sinovas
authors.forename: J
authors.initials: J
authors.lastname: Rosell
authors.forename: I
authors.initials: I
authors.lastname: Anivarro
authors.forename: J
authors.initials: J
authors.lastname: Cinca
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D006328:Cardiac Catheterization / Q000379:methods*; D004195:Disease Models, Animal; D017097:Electric Impedance; D009203:Myocardial Infarction / Q000503:physiopathology*; D013552:Swine