Focal lobular spermatogenesis and pubertal acceleration associated with ipsilateral Leydig cell hyperplasia.
Leydig cell tumors of the testis are the underlying cause in about 10% of the cases of precocious puberty in boys. Leydig cell hyperplasia is a less well-characterized cause, with an undocumented frequency. We describe a boy with precocious puberty associated with ipsilateral testicular enlargement and focal Leydig cell hyperplasia with spermatogenesis limited to the local adjacent testicular tissue.
Leung
A C
AC
Department of Urology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA.
Kogan
S J
SJ
D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D006801:Humans; D006965:Hyperplasia / Q000097:blood / Q000150:complications / Q000601:surgery; D007985:Leydig Cells / Q000473:pathology*; D008297:Male; D009919:Orchiectomy; D011629:Puberty, Precocious / Q000097:blood / Q000209:etiology* / Q000601:surgery; D013091:Spermatogenesis; D013739:Testosterone / Q000097:blood
D015415:Biomarkers; D013739:Testosterone