Ranitidine hydrochloride, a polymorphic crystal form.
In the title compound, dimethyl(¿5-[2-(1-methylamino-2-nitroethenylamino)ethylthiometh yl]-2- furyl¿methyl)ammonium chloride, C(13)H(23)N(4)O(3)S(+).Cl(-), protonation occurs at the dimethylamino N atom. The ranitidine molecule adopts an eclipsed conformation. Bond lengths indicate extensive electron delocalization in the N,N'-dimethyl-2-nitro-1, 1-ethenediamine system of the molecule. The nitro and methylamino groups are trans across the side chain C=C double bond, while the ethylamino and nitro groups are cis. The Cl(-) ions link molecules through hydrogen bonds.
Hempel
A
A
Department of Biochemistry, University of Toronto, Medical Sciences Building, Toronto, Canada M5S 1A8. andrew.hempel@utoronto.ca
Camerman
N
N
Mastropaolo
D
D
Camerman
A
A
D018360:Crystallography, X-Ray; D006635:Histamine H2 Antagonists / Q000737:chemistry*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D008968:Molecular Conformation; D011899:Ranitidine / Q000737:chemistry*
D006635:Histamine H2 Antagonists; D011899:Ranitidine