title: Castleman's disease confined to the leptomeninges.
abstract: We report a rare case of the plasma cell variant of Castleman's disease confined to the leptomeninges in a 42-year-old female. Flow cytometry demonstrated a minor monoclonal kappa light chain population, and conventional Southern blotting confirmed clonal rearrangement of the J(H) immunoglobulin heavy-chain gene. Polymerase chain reaction for Epstein-Barr virus and Kaposi's sarcoma-associated herpes virus was negative. The patient is disease-free five years after surgical resection. To our knowledge, clonal gene rearrangement has not been previously reported in the plasma cell variant of localized intracranial Castleman's disease.
authors.affiliation: Duke University Medical Center, Durham, North Carolina, Department of Pathology, 27710, USA. cummi008@mc.duke.edu
authors.forename: T J
authors.initials: TJ
authors.lastname: Cummings
authors.forename: J Z
authors.initials: JZ
authors.lastname: Gong
authors.forename: A H
authors.initials: AH
authors.lastname: Friedman
authors.forename: R E
authors.initials: RE
authors.lastname: McLendon
mesh_terms: D001099:Arachnoid; D005871:Castleman Disease / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008875:Middle Aged
chemical_list: D007145:Immunoglobulin kappa-Chains