title: Gonadal development in mammals at the cellular and molecular levels.
abstract: In mammals, although sex is determined chromosomally, gonads in both sexes begin development as similar structures. Until recently it was widely held that female development constituted a "default" pathway of development, which would occur in the absence of a testis-determining gene. This master gene on the Y chromosome, SRY in the human and Sry in the mouse, is thought to act in a cell-autonomous fashion to determine that cells in the gonadal somatic population develop as pre-Sertoli cells. Triggering of somatic cell differentiation along the Sertoli cell pathway is therefore a key event; it was thought that further steps in gonadal differentiation would follow in a developmental cascade. In the absence of Sertoli cells, the lack of anti-Mullerian hormone would allow development of the female Mullerian duct and absence of Leydig cells would prevent maintenance of the Wolffian duct. Recent findings that female signals not only maintain the Mullerian duct and repress the Wolffian duct but also suppress the development of Leydig cells and maintain meiotic germ cells, together with the finding that an X-linked gene is required for ovarian development and must be silenced in the male, have shown that the female default pathway model is an oversimplification. Morphological steps in gonadal differentiation can be correlated with emerging evidence of molecular mechanisms; growth factors, cell adhesion, and signaling molecules interact together, often acting within short time windows via reciprocal control relationships.
authors.affiliation: Division of Neuroscience and Biomedical Systems, University of Glasgow, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Mackay
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000502:physiology; D003599:Cytoskeleton; D005109:Extracellular Matrix; D006066:Gonads / Q000196:embryology* / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism / Q000502:physiology; D006728:Hormones / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007382:Intermediate Filaments / Q000378:metabolism / Q000502:physiology; D008322:Mammals; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology; D012733:Sex Differentiation; D015398:Signal Transduction / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; D006133:Growth Substances; D006728:Hormones; D011956:Receptors, Cell Surface