title: Antidermatophytic action of new 1-naphthylmethyl and benzo[b]thiophen-7-ylmethyl hydrazones related to inhibitors of squalene epoxidase.
abstract: Two series of hydrazonic compounds related to main classes of inhibitors of fungal squalene epoxidase (SE) were designed and prepared on the hypothesis of a pharmacophoric model. The antifungal activity of the new compounds was evaluated in vitro against dermatophytes, moulds and yeasts. Antidermatophytic activity resulted for several hydrazones, particularly for those containing a tett-butylacetylenic group, supporting the hypothesis that the introduction of a hydrazonic function in the model could retain the antimycotic activity.
authors.affiliation: Dipartimento Farmaco Chimico Tossicologico, University of Sassari, Italy. anfarm@ssmain.uniss.it
authors.forename: L
authors.initials: L
authors.lastname: Auzzas
authors.forename: M
authors.initials: M
authors.lastname: Palomba
authors.forename: G
authors.initials: G
authors.lastname: Boatto
authors.forename: P
authors.initials: P
authors.lastname: Manconi
authors.forename: A
authors.initials: A
authors.lastname: Pau
authors.forename: A
authors.initials: A
authors.lastname: Becciu
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.forename: V
authors.initials: V
authors.lastname: Tullio
authors.forename: J
authors.initials: J
authors.lastname: Roana
authors.forename: N
authors.initials: N
authors.lastname: Carlone
mesh_terms: D003883:Arthrodermataceae / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D010105:Oxygenases / Q000037:antagonists & inhibitors*; D050603:Squalene Monooxygenase; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D006835:Hydrazones; D009281:Naphthalenes; D013876:Thiophenes; D010105:Oxygenases; D050603:Squalene Monooxygenase