title: Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy.
abstract: This study evaluated mindfulness-based cognitive therapy (MBCT), a group intervention designed to train recovered recurrently depressed patients to disengage from dysphoria-activated depressogenic thinking that may mediate relapse/recurrence. Recovered recurrently depressed patients (n = 145) were randomized to continue with treatment as usual or, in addition, to receive MBCT. Relapse/recurrence to major depression was assessed over a 60-week study period. For patients with 3 or more previous episodes of depression (77% of the sample), MBCT significantly reduced risk of relapse/recurrence. For patients with only 2 previous episodes, MBCT did not reduce relapse/recurrence. MBCT offers a promising cost-efficient psychological approach to preventing relapse/recurrence in recovered recurrently depressed patients.
authors.affiliation: Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom. john.teasdale@mrc-cbu.cam.ac.uk
authors.forename: J D
authors.initials: JD
authors.lastname: Teasdale
authors.forename: Z V
authors.initials: ZV
authors.lastname: Segal
authors.forename: J M
authors.initials: JM
authors.lastname: Williams
authors.forename: V A
authors.initials: VA
authors.lastname: Ridgeway
authors.forename: J M
authors.initials: JM
authors.lastname: Soulsby
authors.forename: M A
authors.initials: MA
authors.lastname: Lau
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control* / Q000628:therapy*; D004739:England; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009864:Ontario; D017063:Outcome Assessment, Health Care; D011569:Psychiatric Status Rating Scales; D055502:Secondary Prevention; D016019:Survival Analysis; D013850:Thinking
chemical_list: D000928:Antidepressive Agents