The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease.
The contribution of the T cell chemoattractant chemokine IFN-inducible protein 10 (IP-10) in host defense following viral infection of the CNS was examined. IP-10 is expressed by astrocytes during acute encephalomyelitis in mouse hepatitis virus-infected mice, and the majority of T lymphocytes infiltrating into the CNS expressed the IP-10 receptor CXCR3. Treatment of mice with anti-IP-10 antisera led to increased mortality and delayed viral clearance from the CNS as compared with control mice. Further, administration of anti-IP-10 led to a >70% reduction (p </= 0.001) in CD4+ and CD8+ T lymphocyte infiltration into the CNS, which correlated with decreased (p </= 0.01) levels of IFN-gamma. These data indicate that IP-10 functions as a sentinel molecule in host defense and is essential in the development of a protective Th1 response against viral infection of the CNS.
Liu
M T
MT
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92612, USA.
Chen
B P
BP
Oertel
P
P
Buchmeier
M J
MJ
Armstrong
D
D
Hamilton
T A
TA
Lane
T E
TE
D000208:Acute Disease; D000818:Animals; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D002630:Chemotactic Factors / Q000502:physiology*; D002908:Chronic Disease; D018352:Coronavirus Infections / Q000276:immunology*; D018792:Encephalitis, Viral / Q000276:immunology / Q000821:virology; D004679:Encephalomyelitis / Q000276:immunology / Q000821:virology; D007106:Immune Sera / Q000008:administration & dosage; D007113:Immunity, Innate; D007274:Injections, Intraperitoneal; D007371:Interferon-gamma / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D006517:Murine hepatitis virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology / Q000821:virology
D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D007106:Immune Sera; D007371:Interferon-gamma