Linking DNA damage and neurodegeneration.
Many human pathological conditions with genetic defects in DNA damage responses are also characterized by neurological deficits. These neurological deficits can manifest themselves during many stages of development, suggesting an important role for DNA repair or processing during the development and maintenance of the nervous system. Although the molecular neuropathology associated with such deficits is largely unknown, many of the responsible gene defects have been identified. The current rapid progress in elucidation of molecular details following gene identification should provide further insight into the importance of DNA processing in nervous system function.
Rolig
R L
RL
Dept of Genetics, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
McKinnon
P J
PJ
D001260:Ataxia Telangiectasia / Q000503:physiopathology; D001816:Bloom Syndrome; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair; D005199:Fanconi Anemia / Q000503:physiopathology; D020271:Heredodegenerative Disorders, Nervous System / Q000235:genetics* / Q000503:physiopathology*; D006801:Humans; D009410:Nerve Degeneration / Q000235:genetics* / Q000503:physiopathology*; D011038:Rothmund-Thomson Syndrome / Q000503:physiopathology; D014898:Werner Syndrome / Q000503:physiopathology; D014983:Xeroderma Pigmentosum / Q000503:physiopathology