[Efficacity of treatment with lamivudine in two patients with severe reactivation of hepatitis B after withdrawal of chemotherapy].
Reactivation of chronic infection is a serious complication during and especially after the withdrawal of cancer chemotherapy in hepatitis B virus carriers. Mortality is high, ranging from 4 to 20%. We report two cases of severe reactivation, after withdrawal of chemotherapy for chronic lymphocytic leukemia in one case and for a bladder tumor in the other. Recovery occurred with lamivudine therapy. Morbidity and mortality are common in these cases, especially when intensive chemotherapy and/or chronic hepatitis and/or precore mutants viruses are involved. Although lamivudine seems to be effective in these cases, prophylactic use has not been clearly defined and must be evaluated.
Seksik
P
P
Service d'Hépato-gastroentérologie et de Médecine Interne, Centre Hospitalier Intercommunal Le Raincy-Montfermeil, Montfermeil.
Nahon
S
S
Lesgourgues
B
B
Cadranel
J F
JF
Mariaud De Serre
N
N
Lenoble
M
M
Lahmeck
P
P
Charoud
A
A
Delas
N
N
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy; D008297:Male; D012008:Recurrence; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000188:drug therapy
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D019259:Lamivudine