Time courses of plasma magnesium concentrations and urinary magnesium excretion in cows subjected to acute changes in potassium intake.
Hypomagnesaemic tetany in cows develops occasionally after an acute increase in K intake such as can occur when cows are transferred to spring grass. There is evidence that under these conditions plasma Mg concentrations are only transiently decreased. In this study the questions addressed were whether the plasma Mg concentration, indeed adapts to a high K intake as only dietary variable, and whether urinary Mg excretion is associated with this adaptation. Dry cows were fed rations containing either 26 or 50 g K/kg dm, the extra K being in the form of KHCO3. When the cows were acutely transferred from the low to the high K ration, plasma Mg concentrations fell slightly, but significantly from 0.86 to 0.76 mmol/l within five days, but rose again to 0.80 mmol/l after another 23 days, this rise being also statistically significant. None of the animals developed tetany. The decrease in plasma Mg concentration in individual animals after five days on the high-K ration ranged from 6 to 21%. The time course of urinary Mg excretion resembled that of plasma Mg concentration; minimum Mg excretion was seen after four to six days on the high-K ration with a subsequent increase thereafter. To explain the transient lowering of plasma Mg concentration, it is suggested that the K-induced decrease in Mg status caused a delayed increase in the carrier-mediated component of Mg absorption, which in turn caused an increase in urinary Mg excretion. When the cows were acutely switched from the high to the low K ration, plasma Mg concentration and urinary Mg excretion rose, but no transient changes were seen.
Schonewille
J T
JT
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
van 't Klooster
A T
AT
Wouterse
H
H
Beynen
A C
AC
D000220:Adaptation, Biological; D000818:Animals; D001639:Bicarbonates / Q000008:administration & dosage; D002417:Cattle / Q000378:metabolism*; D018592:Cross-Over Studies; D005260:Female; D008274:Magnesium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006109:Poaceae / Q000737:chemistry*; D017680:Potassium Compounds / Q000008:administration & dosage; D017419:Potassium, Dietary / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D013746:Tetany / Q000517:prevention & control / Q000662:veterinary; D013997:Time Factors
D001639:Bicarbonates; D017680:Potassium Compounds; D017419:Potassium, Dietary; C026329:potassium bicarbonate; D008274:Magnesium