[Experimental animal study of the safety of biologically active food supplement obtained from ginseng root].
The aim of present study was an investigations of safety of product "Bioton-1" which is suggested as biologically active food additive. Long-term intake the product "Bioton-1" by the rats Wistar during 6 month at doses of 0.75 ml per kg of body weight hadn't an unfavorable effects on integral, biochemical, hemotologic and morphologic parameters of animals. It was shown on two generations of rats that "Bioton-1" hadn't an embryotoxic, gonadotoxic and teratogenic effects and also hadn't negative effect on growth and development of posterity of rats. Including into the diet of rats product "Bioton-1" at dose of 0.25 per kg of body weight during the whole life hadn't an effect on animals life duration.
Sorokina
E Iu
EIu
Aksiuk
I N
IN
Kirpatovskaia
N A
NA
Levitskaia
A B
AB
D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects; D007136:Immunoglobulins / Q000032:analysis; D007962:Leukocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009152:Mutagenicity Tests; D005894:Panax / Q000009:adverse effects; D010936:Plant Extracts / Q000633:toxicity; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012449:Safety; D013997:Time Factors; D018675:Toxicity Tests
D007136:Immunoglobulins; D010936:Plant Extracts