Dietary fatty acids influence the appearance of tumour necrosis factor-alpha receptors on adipocytes following an immune challenge.
Rats were fed from weaning on chow supplemented with suet or sunflower oil (10 % (w/w) each). The appearance of receptors for tumour necrosis factor-alpha on perinodal adipocytes from the popliteal depot following a subcutaneous injection of bacterial lipopolysaccharide was examined. In rats fed on sunflower oil-supplemented chow receptors appeared at a time similar to that described in rats fed unsupplemented chow, but in rats fed on chow supplemented with suet receptor appearance was significantly delayed. The popliteal adipocytes were found to contain different proportions of fatty acids as assessed by GLC. These preliminary results suggest that the fatty acid component of the diet can, by influencing the triacylglycerol-fatty acids within adipocytes, directly alter the time course of an early inflammatory immune response.
MacQueen
H A
HA
Department of Biological Sciences, The Open University, Milton Keynes, MK7 6AA, UK. h.a.macqueen@open.ac.uk
Sadler
D
D
Mattacks
C
C
D017667:Adipocytes / Q000276:immunology*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology*; D000074242:Sunflower Oil
D004041:Dietary Fats; D010938:Plant Oils; D018124:Receptors, Tumor Necrosis Factor; D000074242:Sunflower Oil