A pharmacokinetic interpretation of increasing concentrations of DEHP in haemodialysed patients.
The degree of exposure to DEHP was assessed in 11 patients with chronic renal failure undergoing maintenance haemodialysis. The amount of DEHP leached from the dialyser during a 4-h dialysis session was estimated by monitoring the DEHP blood concentration using a HPLC method. When a patient undergoes a dialysis treatment, the concentration of di-2-ethylhexyl phthalate (DEHP) in venous blood is increased when the blood crosses through the dialysis apparatus. This increase may be explained either because DEHP is not extracted by the dialyser or because DEHP comes from the dialysis bath due to contact of blood against plasticized pipes. To explain the increasing concentration of DEHP during treatment of renal failure using plasticized tubing, we propose a pharmacokinetic compartmental model in order to fit raw data obtained from dialysed patients and to get the amount of DEHP which enters the body by AUC calculations. Results obtained after HPLC analysis show a high degree of interpatient variability in DEHP retained. This amount can reach a toxicity level because of repetitive dialysis treatments over prolonged periods of time. In the coming years, it seems necessary to reconsider the use of DEHP as a plasticizer in medical devices. Highly unacceptable amounts of DEHP leached during the dialysis session could be easily avoided by careful selection of haemodialysis tubing.
Dine
T
T
Laboratoire de Pharmacologie, Pharmacocinétique et Pharmacie Clinique, Faculté des Sciences Pharmaceutiques, 3 rue du Professeur Laguesse BP83, F59006 Cedex, Lille, France.
Luyckx
M
M
Gressier
B
B
Brunet
C
C
Souhait
J
J
Nogarede
S
S
Vanpoucke
J
J
Courbon
F
F
Plusquellec
Y
Y
Houin
G
G
D000328:Adult; D000368:Aged; D019540:Area Under Curve; D001825:Body Fluid Compartments; D056486:Chemical and Drug Induced Liver Injury; D002851:Chromatography, High Pressure Liquid; D004051:Diethylhexyl Phthalate / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D004781:Environmental Exposure / Q000517:prevention & control; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008107:Liver Diseases / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010968:Plasticizers / Q000493:pharmacokinetics* / Q000633:toxicity; D011143:Polyvinyl Chloride; D006435:Renal Dialysis
D010968:Plasticizers; D011143:Polyvinyl Chloride; D004051:Diethylhexyl Phthalate