[Change in metabolic risk factors in obese patients in treatment].
BACKGROUND
Obesity is a threat to health due to its association with cardiovascular risk factors.


OBJECTIVE
To assess the change in metabolic risk factors after weight reduction in obese patients.


METHODS
A retrospective analysis of 277 obese patients (198 female) aged 39.5 +/- 12 years old, that completed a six month treatment period, consisting in a calorie restricted diet (800-1200 Kcal/day), physical activity, education and group psychological counseling. At the beginning and at the end of the program, weight, waist circumference, resting energy expenditure (REE), serum lipid profile, plasma glucose and plasma insulin levels were measured.


RESULTS
During the treatment period, body mass index decreased from 38 +/- 7 to 33.2 +/- 6.4 kg/m2 with a weight loss of 11.7 kg, waist circumference decreased from 106.6 +/- 14.6 to 93.9 +/- 13.5 cm, REE decreased from 1774 +/- 383 to 1585 +/- 267 Kcal/day, blood glucose fell by 5.8%, plasma insulin fell by 40.4%, total cholesterol fell by 7.5%, LDL cholesterol fell by 8.7%, triglycerides fell by 26.6%, and total cholesterol/HDL ratio fell by 12.2%.


CONCLUSIONS
Weight loss was associated with improvement in metabolic cardiovascular risk factors in obese patients.
Moreno
M
M
Departamento de Nutrición, Diabetes y Metabolismo, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. mmoreno@med.puc.cl
Manrique
M
M
Guzmán
S
S
Maiz
A
A
Patiño
C
C
Valdés
R
R
Feuchtmann
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000517:prevention & control; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism* / Q000628:therapy*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D015431:Weight Loss
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids