title: [Lyme disease in Upper Normandy: report of a hospital survey].
abstract: This study presents the results of a hospital survey on Lyme disease in children living in upper Normandy, a region that is quite densely wooded (with 18% forest areas and woods). The aim of this survey was to assess the prevalence of this disease in children from the Seine-Maritime and L'Eure, hospitalized in pediatric wards in the Seine-Maritime department, which includes Rouen, Dieppe, Fécamp, Elbeuf, and Le Havre. Fifteen cases of Lyme disease were diagnosed between September 1988 and June 1997. The children (6 girls and 9 boys) were aged between 5 and 14 years old. Only 7 subjects showed primary symptoms, while secondary symptoms were observed in 12 children. In the study population, a high prevalence (11 out of the 15 children) of neurological disorders was found. The following secondary symptoms were noted: 5 cases of erythema migrans, 2 cases of non-malignant cutaneous lymphocytoma, and 4 cases which in fact had previously displayed primary clinical signs (3 subjects with erythema migrans and 1 subject with non-malignant cutaneous lymphocytoma); 7 cases of uni- or bilateral facial paralysis, the most frequent neurological manifestation with or without lymphocytic meningitis; 1 case of central vestibular syndrome with a hyperalgesic meningoradicular reaction in the vicinity of the tick bite; 1 case of peripheral radicular involvement and intense pain in the left lower limb; 4 cases of ocular disorders (3 diplopias, 1 bilateral conjunctivitis complicated by kerato-uveitis, 1 bilateral complete cecitis). Only 10 child had rheumatological symptoms, i.e., Lyme arthritis of the right knee. Treatment consisted of amoxicillin (10 children) administered at a dosage of 50 to 100 mg/kg/d over a period ranging from 10 days to 1 month, or ceftriaxone (7 children) at a dosage of 50 to 100 mg/kg/d administered intravenously over a period ranging from 8 days to 3 weeks. Two of the children received combined antibiotic therapy, and 5 subjects had adjunct corticotherapy.
authors.affiliation: Service de pédiatrie CHU Charles-Nicolle, Rouen, France.
authors.forename: C
authors.initials: C
authors.lastname: Marguet
authors.forename: M
authors.initials: M
authors.lastname: Rouillier-Saas
authors.forename: E
authors.initials: E
authors.lastname: Mallet
authors.forename: M
authors.initials: M
authors.lastname: Meunier
authors.forename: E
authors.initials: E
authors.lastname: Jeannot
authors.forename: J
authors.initials: J
authors.lastname: Boulloche
authors.forename: C
authors.initials: C
authors.lastname: Forget
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015748:Borrelia burgdorferi Group / Q000302:isolation & purification; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D006306:Health Surveys; D006760:Hospitalization; D006801:Humans; D008193:Lyme Disease / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D015995:Prevalence; D012698:Serologic Tests
chemical_list: D000900:Anti-Bacterial Agents