Salivary glands as a model for craniofacial applications of gene transfer.
The potential applications of gene transfer technology to all branches of medicine are increasing. It is quite likely that within the next 10-20 years surgical practice routinely will utilize gene transfer, at least adjunctively. The purpose of this review is to familiarize the oral and maxillofacial surgeon with this technology. Studies performed with salivary glands in animal models are presented as examples of proof of concept.
Baum
B J
BJ
Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA. bruce_j_baum@nih.gov
Goldsmith
C M
CM
Hoque
A T
AT
Wellner
R B
RB
Baccaglini
L
L
Ding
C
C
Yamano
S
S
Zheng
C
C
Aframian
D J
DJ
Zheng
C
C
Aframian
D J
DJ
O'Connell
B C
BC
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D023421:Models, Animal; D051381:Rats; D012466:Salivary Gland Diseases / Q000628:therapy; D012469:Salivary Glands / Q000293:injuries / Q000503:physiopathology
D000914:Antibodies, Viral