Anti-inflammatory evaluation of Ficus racemosa Linn. leaf extract.
The anti-inflammatory activity of Ficus racemosa extract was evaluated on carrageenin, serotonin, histamine and dextran-induced rat hind paw oedema models. The extract at doses of 200 and 400 mg/kg has been found to possess significant anti-inflammatory activity on the tested experimental models. The extract (400 mg/kg) exhibited maximum anti-inflammatory effect, that is 30.4, 32.2, 33.9 and 32.0% at the end of 3 h with carrageenin, serotonin, histamine, dextran-induced rat paw oedema, respectively. In a chronic test the extract (400 mg/kg) showed 41.5% reduction in granuloma weight. The effect produced by the extract was comparable to that of phenylbutazone, a prototype of a non-steroidal anti-inflammatory agent.
Mandal
S C
SC
Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta 700 032, India.
Maity
T K
TK
Das
J
J
Saba
B P
BP
Pal
M
M
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D005528:Foot / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006632:Histamine; D007194:India; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D010936:Plant Extracts; D012701:Serotonin; D006632:Histamine; D002351:Carrageenan; D010653:Phenylbutazone