Hormonal modulation of GM-CSF receptor alpha-chain in in vitro models of endometrial cancer.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that stimulates the proliferation and differentiation of bone marrow progenitors. Moreover, the presence and activity of GM-CSF and its receptor (GM-CSF-r) has been documented on tissues and cell lines of a non-hemopoietic origin. In this paper we studied the expression and putative role of GM-CSF and GM-CSF-r in endometrial cancer. The modulation of GM-CSF-r alpha-chain upon progesterone treatment suggests a role for GM-CSF and its receptor in the pathogenesis and development of endometrial cancer.
Baj
G
G
Laboratory of Gnecological Oncology, Department of Medical Sciences, University A. Avogadro of Eastern Piedmont, Novara, Italy.
Arnulfo
A
A
Boldorini
R
R
Nicosia
G
G
Villa
L
L
Malavasi
F
F
Surico
N
N
D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D016889:Endometrial Neoplasms / Q000737:chemistry* / Q000209:etiology; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology; D011374:Progesterone / Q000494:pharmacology*; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D014407:Tumor Cells, Cultured
D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D015735:Mifepristone; D011374:Progesterone; D016178:Granulocyte-Macrophage Colony-Stimulating Factor