[Thymidine phosphorylase and angiogenesis].
Thymidine phosphorylase (TP) is identical to platelet-derived endothelial cell growth factor (PD-ECGF). TP has an angiogenic activity and confers resistance to hypoxia-induced apoptosis on cells. TP expression is correlated with microvessel count, invasion and poor prognosis in many solid tumors. TPI, an inhibitor of TP, suppresses growth and metastasis of tumors by inhibiting the effect of TP.
Akiyama
S
S
Dept. of Cancer Chemotherapy, Faculty of Medicine, Kagoshima University.
D017209:Apoptosis; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000201:enzymology*; D011379:Prognosis; D013939:Thymidine Phosphorylase / Q000502:physiology*
D013939:Thymidine Phosphorylase