title: Regulation of host cell translation by viruses and effects on cell function.
abstract: Viruses have evolved a remarkable variety of strategies to modulate the host cell translation apparatus with the aim of optimizing viral mRNA translation and replication. Recent studies have revealed that modulation of both host and viral mRNA translation can be accomplished by selective alteration of translation factors in virus-infected cells. These findings provide new insights into the functioning of the translational apparatus in both uninfected and infected cells.
authors.affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305, USA. srthompson@leland.stanford.edu
authors.forename: S R
authors.initials: SR
authors.lastname: Thompson
authors.forename: P
authors.initials: P
authors.lastname: Sarnow
mesh_terms: D000818:Animals; D002460:Cell Line; D005786:Gene Expression Regulation; D015683:Gene Products, gag / Q000378:metabolism; D015488:HIV Antigens / Q000378:metabolism; D016174:Hepacivirus / Q000502:physiology; D006564:Herpesviridae / Q000502:physiology; D006801:Humans; D010445:Peptide Elongation Factors / Q000378:metabolism; D010448:Peptide Initiation Factors / Q000378:metabolism; D017955:Poliovirus / Q000235:genetics / Q000502:physiology*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D014764:Viral Proteins; D018406:Virus Physiological Phenomena; D019892:eIF-2 Kinase; D054301:gag Gene Products, Human Immunodeficiency Virus
chemical_list: D015683:Gene Products, gag; D015488:HIV Antigens; D010445:Peptide Elongation Factors; D010448:Peptide Initiation Factors; D012333:RNA, Messenger; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C054858:p17 protein, Human Immunodeficiency Virus Type 1; D019892:eIF-2 Kinase