Determination of the activity of ponazuril against Sarcocystis neurona in cell cultures.
The present study examined the efficacy of ponazuril in inhibiting merozoite production of Sarcocystis neurona in cell cultures. Ponazuril inhibited merozoite production by more that 90% in cultures of S. neurona treated with 1.0 microg/ml ponazuril and greater than 95% inhibition of merozoite production was observed when infected cultures were treated with 5.0 microg/ml ponazuril. Ponazuril may have promise as a therapeutic agent in the treatment of S. neurona induced equine protozoal myeloencephalitis (EPM) in horses.
Lindsay
D S
DS
Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, 24061-0342, USA. lindsayd@vt.edu
Dubey
J P
JP
Kennedy
T J
TJ
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D004679:Encephalomyelitis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D006734:Horse Diseases / Q000188:drug therapy / Q000469:parasitology; D006736:Horses; D012522:Sarcocystis / Q000187:drug effects* / Q000254:growth & development; D012523:Sarcocystosis / Q000188:drug therapy / Q000662:veterinary; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use
D000981:Antiprotozoal Agents; D014227:Triazines; C415002:ponazuril