Indium-111 leukocyte scintigraphy in suspected bowel ischemia.
OBJECTIVE
The purpose of this study was to evaluate the utility of indium-111 leukocyte (In-111 WBC) scintigraphy in a large number of patients with suspected bowel ischemia.


METHODS
All patients who underwent In-111 WBC scintigraphy for possible bowel ischemia over a 4-yr period and had subsequent endoscopic or surgical biopsy were retrospectively evaluated. Early (1-4 h postinjection) and late (18-24 h postinjection) images were obtained. Any study with tracer activity in the bowel on early or late images was considered positive for bowel ischemia.


RESULTS
Fifty-nine patients were included in the analysis. In-111 WBC scintigraphy detected 23 of 24 cases of bowel ischemia (sensitivity = 96%). Of 35 cases without ischemia, 16 had a negative In-111 WBC scintiscan (specificity = 46%). Negative and positive predictive values for the diagnosis of bowel ischemia were 94% and 55%, respectively. Of the 19 cases without bowel ischemia and a positive scintiscan, 15 had another intraabdominal process responsible for the patients' symptomatology.


CONCLUSIONS
In-111 WBC scintigraphy is a highly sensitive diagnostic tool for bowel ischemia. A normal In-111 WBC scintiscan strongly suggests that this disease is not present.
Dhekne
R D
RD
Department of Radiology, Baylor College of Medicine, Houston, Texas, USA.
Chatziioannou
S N
SN
Moore
W H
WH
Ford
P V
PV
Hochman
F L
FL
D000368:Aged; D001706:Biopsy; D004724:Endoscopy; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007422:Intestines / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000175:diagnosis* / Q000473:pathology; D007962:Leukocytes / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
D007205:Indium Radioisotopes