title: Determination of the activity of ponazuril against Sarcocystis neurona in cell cultures.
abstract: The present study examined the efficacy of ponazuril in inhibiting merozoite production of Sarcocystis neurona in cell cultures. Ponazuril inhibited merozoite production by more that 90% in cultures of S. neurona treated with 1.0 microg/ml ponazuril and greater than 95% inhibition of merozoite production was observed when infected cultures were treated with 5.0 microg/ml ponazuril. Ponazuril may have promise as a therapeutic agent in the treatment of S. neurona induced equine protozoal myeloencephalitis (EPM) in horses.
authors.affiliation: Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, 24061-0342, USA. lindsayd@vt.edu
authors.forename: D S
authors.initials: DS
authors.lastname: Lindsay
authors.forename: J P
authors.initials: JP
authors.lastname: Dubey
authors.forename: T J
authors.initials: TJ
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D004679:Encephalomyelitis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D006734:Horse Diseases / Q000188:drug therapy / Q000469:parasitology; D006736:Horses; D012522:Sarcocystis / Q000187:drug effects* / Q000254:growth & development; D012523:Sarcocystosis / Q000188:drug therapy / Q000662:veterinary; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D014227:Triazines; C415002:ponazuril