title: The role of the t-PA I/D and PAI-1 4G/5G polymorphisms in African-American adults with a diagnosis of myocardial infarction or venous thromboembolism.
abstract: To determine whether or not the PAI-1 4G/5G and t-PA I/D polymorphisms in African-Americans were linked to cardiovascular disease, the association of these polymorphisms to disease expression was analyzed in a recently completed case-control study of myocardial infarction or venous thromboembolism among African-Americans. All African-Americans patients with a history of venous thromboembolism attending an anticoagulant clinic, and patients with a history of a MI attending a cardiology clinic at a large local urban public hospital were eligible for inclusion as cases in the study. In this study it was observed that there was a statistically significant association between the D allele of the t-PA I/D polymorphism and venous thromboembolism and a nonsignificant association between the D allele and myocardial infarction among African-Americans. t-PA antigen levels were statistically significantly higher among both myocardial infarction and venous thromboembolism cases compared with control subjects. The genotypes were unrelated to t-PA plasma levels. There was no association between either myocardial infarction or venous thromboembolism and the 4G/5G PAI-1 genotype. It was also found that genotype frequencies for both PAI-1 4G/5G and t-PA I/D polymorphisms in African-American adults were different from those reported for both U.S. Causcians and Europeans.
authors.affiliation: Hematologic Disease Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. wohl@cdc/gov
authors.forename: W C
authors.initials: WC
authors.lastname: Hooper
authors.forename: C
authors.initials: C
authors.lastname: Lally
authors.forename: H
authors.initials: H
authors.lastname: Austin
authors.forename: M
authors.initials: M
authors.lastname: Renshaw
authors.forename: A
authors.initials: A
authors.lastname: Dilley
authors.forename: N K
authors.initials: NK
authors.lastname: Wenger
authors.forename: D J
authors.initials: DJ
authors.lastname: Phillips
authors.forename: C
authors.initials: C
authors.lastname: Whitsett
authors.forename: P
authors.initials: P
authors.lastname: Rawlins
authors.forename: B L
authors.initials: BL
authors.lastname: Evatt
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000208:ethnology* / Q000235:genetics; D016017:Odds Ratio; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012306:Risk; D010959:Tissue Plasminogen Activator / Q000235:genetics*; D020246:Venous Thrombosis / Q000208:ethnology* / Q000235:genetics
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator