Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD.
An association between cognitive performance in elderly people and variability in the codon 129 of the prion protein gene (PRNP) has been recently described. The authors analyzed this polymorphism in 278 sporadic AD patients and 268 cognitively normal control subjects. Analyses stratifying by APOE genotype, age, and gender failed to reveal any association between homozygosity for the 129 PRNP methionine or valine alleles and AD.
Combarros
O
O
Service of Neurology, University Hospital Marqués de Valdecilla, Santander, Spain. neuro@humv.es
Sánchez-Guerra
M
M
Llorca
J
J
Alvarez-Arcaya
A
A
Berciano
J
J
Peña
N
N
Fernández-Viadero
C
C
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D019943:Amino Acid Substitution / Q000235:genetics; D000682:Amyloid / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D000072002:Prion Proteins; D011328:Prions; D011498:Protein Precursors / Q000235:genetics*; D018570:Risk Assessment; D013030:Spain / Q000453:epidemiology; D044465:White People / Q000235:genetics
D000682:Amyloid; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions; D011498:Protein Precursors