[Metabolic heterogeneity of glycogen in hepatocytes of patients with liver cirrhosis].
Concentrations of the total glycogen (TG) and of its labile and stable fractions (LF and SF, respectively) were determined in hepatocytes of portal and central zones of the normal human liver and in the liver of patients with cirrhosis of viral and alcohol etiology. Using the PAS reaction, TG and its LF and SF were revealed in histological sections of the material obtained by liver punction biopsies. Concentrations of TG and its fractions were measured by television cytophotometry. In liver cirrhosis, concentrations of TG, LF, and SF in both zones of the hepatic lobule were much higher than in the normal liver. The ratio between hepatocyte TG concentration in the portal zone and that in the central zone (P/C ratio), both in norm and in viral cirrhosis, exceeds 1.0 to reach, respectively, 1.26 +/- 0.02 and 1.03 +/- 0.01. The glycogen fraction composition in cells of both liver lobule zones in viral cirrhosis does not significantly differ from that in norm. On the contrary, in the liver of patients with alcoholic cirrhosis, the P/C ratio falls to 0.82 +/- 0.02 to be accompanied by qualitative changes in glycogen composition.
Kudriavtseva
M V
MV
Institute of Cytology RAS, St. Petersburg.
Bezborodkina
N N
NN
Radchenko
V G
VG
Okovityĭ
S V
SV
Ivanova
O V
OV
Kudriavtsev
B N
BN
D006801:Humans; D008099:Liver / Q000648:ultrastructure*; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism / Q000473:pathology; D008112:Liver Glycogen / Q000378:metabolism*
D008112:Liver Glycogen