[Characteristics of epidemiological strains of influenza A virus (H3N2) isolate in 1997-1999. Virus A/Moscow/10/99--a candidate to become the vaccine strain].
Antigenic properties of influenza A(H3N2) viruses isolated during two epidemic seasons 1997-98 and 1998-99 in Russia are analyzed. All strains are antigenic variants of the reference strain A/Sydney/5/97. Characteristics of epidemic strain A/Moscow/10/99, proposed by WHO expert committee as vaccine strain for 1999-2000 have been studied. This strain, isolated on chick embryos, is characterized by high reproductive activity in chicken embryos with an infectious titer of 10(6) EID50/0.2 ml, easily adapts to MDCK culture, and has a thermostable hemagglutinin.
Slepushkin
A N
AN
Ivanova
V T
VT
Burtseva
E I
EI
Oskerko
T A
TA
Volodina
T N
TN
Kuribko
S G
SG
Kolobukhina
L V
LV
Beda
M V
MV
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D002642:Chick Embryo; D004196:Disease Outbreaks; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000276:immunology / Q000302:isolation & purification*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology*; D009031:Moscow / Q000453:epidemiology
D000956:Antigens, Viral; D007252:Influenza Vaccines