Cytotoxity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line.
Seven taxane diterpenes were isolated from the EtOH extract of the aerial parts of Taxus chinensis, and evaluated for cytotoxicity against nine human cell lines, including a beta-tublin mutant resistant to paclitaxel. Compound 2, a non-alkaloid-type taxane diterpene, showed significant cytotoxicity in most cell lines, and notably, equipotent against both parental and beta-tublin mutant tumor cell lines.
Fukushima
M
M
Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi- 739-8521, Hiroshima, Japan.
Fukamiya
N
N
Okano
M
M
Nehira
T
T
Tagahara
K
K
Zhang
S X
SX
Zhang
D C
DC
Tachibana
Y
Y
Bastow
K F
KF
Lee
K H
KH
D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D017239:Paclitaxel / Q000494:pharmacology*; D010946:Plants, Medicinal; D020946:Taxus / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
D004224:Diterpenes; D017239:Paclitaxel