Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B.
An efficient new process is described for the synthesis of ecteinascidin ET-743 (1) and phthalascidin (2), starting from readily available cyanosafracin B (3).
Cuevas
C
C
Pharma Mar, S. A. C/ de la Calera 3, 28760-Tres Cantos, Madrid, Spain.
Pérez
M
M
Martín
M J
MJ
Chicharro
J L
JL
Fernández-Rivas
C
C
Flores
M
M
Francesch
A
A
Gallego
P
P
Zarzuelo
M
M
de La Calle
F
F
García
J
J
Polanco
C
C
Rodríguez
I
I
Manzanares
I
I
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000737:chemistry; D001392:Azocines; D004149:Dioxoles / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry; D011809:Quinones; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin
D018906:Antineoplastic Agents, Alkylating; D001392:Azocines; D004149:Dioxoles; D007202:Indicators and Reagents; D007546:Isoquinolines; D010797:Phthalimides; D011809:Quinones; D044005:Tetrahydroisoquinolines; C413208:cyanosafracin B; C118707:phthalascidin; D000077606:Trabectedin