title: Age-related changes in bone mineral density and serum bone-related proteins in premenopausal and postmenopausal Japanese women.
abstract: The purpose of this cross-sectional study was to characterize the age-related change in bone metabolism during the pre- and postmenopausal periods, and to define the standard levels of three serum markers of bone metabolism, pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), carboxyterminal propeptide of type I procollagen (PICP), and bone gla protein (BGP), in Japanese adult women. The bone mineral density (BMD) of the lumbar spine (L2-L4) and the serum levels of ICTP, PICP and BGP were determined in a total of 207 healthy Japanese women (108 premenopausal and 99 postmenopausal). The lumbar BMD decreased significantly with increasing age not only in postmenopausal women (P<0.001) but also in premenopausal women (P=0.014). There was a clear gap in the serum levels of ICTP, PICP and BGP between the premenopausal and postmenopausal group (P<0.001), but those were absolutely the same within each group except for ICTP in the postmenopausal women. These findings and the values of serum ICTP, PICP and BGP in pre- and postmenopausal women obtained in this study are expected to be very useful for treatment of postmenopausal osteoporosis.
authors.affiliation: Department of Obstetrics and Gynecology, Yamanashi Medical University, Tamaho, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yasumizu
authors.forename: T
authors.initials: T
authors.lastname: Okuno
authors.forename: Y
authors.initials: Y
authors.lastname: Fukada
authors.forename: K
authors.initials: K
authors.lastname: Hoshi
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D015415:Biomarkers / Q000097:blood*; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D005260:Female; D006801:Humans; D007564:Japan; D008159:Lumbar Vertebrae; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D017698:Postmenopause; D017697:Premenopause; D011347:Procollagen / Q000097:blood
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; D003094:Collagen