title: Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer.
abstract: Tazarotene-induced gene-3 (TIG-3), isolated from human keratinocytes treated with the retinoic acid receptor-selective retinoid Tazarotene, is homologous to H-rev, a class II tumor suppressor. TIG-3 gene localized to chromosome 11q23, a site of loss of heterozygosity in several malignancies. Retinoids influence epidermal differentiation and are used to treat and prevent skin cancer. Therefore, we studied TIG-3 mRNA expression in psoriasis and in basal and SCCs by in situ hybridization and a quantitative QT-RT-PCR assay. Psoriasis lesions had significantly lower staining (median, 3) than paired normal control skin (median, 4; P = 0.012). TIG-3 mRNA was significantly higher in normal control skin (P = 0.001), in paired adjacent skin (median, 3; P = 0.007), and in overlying epidermis (median, 3.0; P = 0.0001) than in 21 SCC specimens as a group (median, 1.5).
authors.affiliation: Department of Internal Medical Specialties, M. D. Anderson Cancer Center, Houston, Texas 77030, USA. mduvic@mdanderson.org
authors.forename: M
authors.initials: M
authors.lastname: Duvic
authors.forename: B
authors.initials: B
authors.lastname: Helekar
authors.forename: C
authors.initials: C
authors.lastname: Schulz
authors.forename: M
authors.initials: M
authors.lastname: Cho
authors.forename: D
authors.initials: D
authors.lastname: DiSepio
authors.forename: C
authors.initials: C
authors.lastname: Hager
authors.forename: D
authors.initials: D
authors.lastname: DiMao
authors.forename: P
authors.initials: P
authors.lastname: Hazarika
authors.forename: B
authors.initials: B
authors.lastname: Jackson
authors.forename: J
authors.initials: J
authors.lastname: Breuer-McHam
authors.forename: J
authors.initials: J
authors.lastname: Young
authors.forename: G
authors.initials: G
authors.lastname: Clayman
authors.forename: S M
authors.initials: SM
authors.lastname: Lippman
authors.forename: R A
authors.initials: RA
authors.lastname: Chandraratna
authors.forename: N A
authors.initials: NA
authors.lastname: Robinson
authors.forename: A
authors.initials: A
authors.lastname: Deucher
authors.forename: R L
authors.initials: RL
authors.lastname: Eckert
authors.forename: S
authors.initials: S
authors.lastname: Nagpal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics*; D004817:Epidermis / Q000378:metabolism / Q000502:physiology; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D018168:Receptors, Retinoic Acid; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D012879:Skin Physiological Phenomena
chemical_list: D002352:Carrier Proteins; C437968:PLAAT4 protein, human; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid