Optic nerve oxygen tension: effects of intraocular pressure and dorzolamide.
OBJECTIVE
To investigate the influence of acute changes in intraocular pressure on the oxygen tension in the vicinity of the optic nerve head under control conditions and after intravenous administration of 500 mg of the carbonic anhydrase inhibitor dorzolamide.


METHODS
Domestic pigs were used as experimental animals. Oxygen tension was measured by means of a polarographic electrode in the vitreous 0.5 mm anterior to the optic disc. This entity is called the optic nerve oxygen tension. Intraocular pressure was controlled by a hypodermic needle inserted into the anterior chamber and connected to a saline reservoir.


RESULTS
When the intraocular pressure was clamped at 20 cm H2O optic nerve oxygen tension was 20 (5) mm Hg (n=8). Intravenous administration of dorzolamide caused an increase in optic nerve oxygen tension of 43 (8)% (n=6). Both before and after administration of dorzolamide optic nerve oxygen tension was unaffected by changes in intraocular pressure, as long as this pressure remained below 60 cm H2O. At intraocular pressures of 60 cm H(2)O and below, dorzolamide significantly increased optic nerve oxygen tension.


CONCLUSIONS
Intravenous administration of 500 mg dorzolamide increases the oxygen tension at the optic nerve head during acute increases in intraocular pressure.
la Cour
M
M
Eye Department, National University Hospital, University of Copenhagen, Denmark. m.la.cour@dadlnet.dk
Kiilgaard
J F
JF
Eysteinsson
T
T
Wiencke
A K
AK
Bang
K
K
Dollerup
J
J
Jensen
P K
PK
Stefánsson
E
E
D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D005901:Glaucoma / Q000188:drug therapy; D007262:Infusions, Intravenous; D007429:Intraocular Pressure / Q000502:physiology*; D009900:Optic Nerve / Q000187:drug effects* / Q000502:physiology; D010100:Oxygen / Q000032:analysis*; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D013552:Swine; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology*
D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide; D010100:Oxygen