title: Colonic perforation associated with slow-release diclofenac sodium.
abstract: Upper gastrointestinal tract complications due to non-steroidal anti-inflammatory drugs are well recognised. However, adverse effects on large intestinal mucosa are less common and less well recognised, even though they carry a significant morbidity and mortality. Here we report a case of colonic perforation in a healthy woman without any underlying colonic pathology associated with ingestion of slow release diclofenac sodium.
authors.affiliation: Department of Geriatric Medicine, Wrexham Maelor Hospital, Wrexham, Clwyd, UK.
authors.forename: V
authors.initials: V
authors.lastname: Adhiyaman
authors.forename: M
authors.initials: M
authors.lastname: Asghar
authors.forename: A D
authors.initials: AD
authors.lastname: White
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003108:Colonic Diseases / Q000139:chemically induced*; D004008:Diclofenac / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D007416:Intestinal Perforation / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac