Cytokines: regulators of eosinophilic inflammation.
Cytokines are glycoproteins that are secreted and that regulate immunologic inflammation. The cytokine system is characterized by much redundancy and cross-reactivity. Of the more than 100 cytokines that have been identified, interleukin-5 (IL-5) and the chemokine (chemotactic cytokine), eotaxin, are the most selective for cells of eosinophilic origin. Because of this relative specificity, and because of their important immunoregulatory roles, IL-5, eotaxin, and their receptors IL-5R and CCR3 are potential targets for non-glucocorticosteroid pharmacological treatment of eosinophilic inflammation.
Weltman
J K
JK
Brown University School of Medicine, Fall River, Massachusetts 02720, USA.
D054413:Chemokine CCL11; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil / Q000737:chemistry / Q000276:immunology; D016207:Cytokines / Q000737:chemistry / Q000276:immunology*; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D015848:Interleukin-5 / Q000276:immunology; D015394:Molecular Structure; D018123:Receptors, Interleukin / Q000276:immunology; D015398:Signal Transduction
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D016207:Cytokines; D015848:Interleukin-5; D018123:Receptors, Interleukin