title: Postoperative sore throat and hoarseness following tracheal intubation using air or saline to inflate the cuff--a randomized controlled trial.
abstract: Sore throat and hoarseness following tracheal intubation is common. The aetiology may include high tracheal cuff pressures. We performed a double-blind, randomized controlled trial in 126 intubated patients to compare the incidence and severity of sore throat and hoarseness following inflation of the cuff using air or saline. Intra-cuff pressures were compared to assess any change due to inward diffusion of nitrous oxide. The incidence of significant sore throat and/or hoarseness overall was 15.0%. There was no statistically significant difference between the groups (air 15.9%, saline 14.5%). In the air group mean intra-cuff pressure increased significantly (start 14.0 mmHg, end 40.9 mmHg), while in the saline group there was no significant increase (start 12.7 mmHg, end 14.6 mmHg). The substitution of saline reliably results in sustained low intra-cuff pressures but high tracheal cuff pressure is not an important factor in the development of sore throat or hoarseness postoperatively within the pressure range and duration of operation studied.
authors.affiliation: Division of Anaesthesia, Prince of Wales Hospital, Sydney, New South Wales.
authors.forename: M H
authors.initials: MH
authors.lastname: Bennett
authors.forename: P R
authors.initials: PR
authors.lastname: Isert
authors.forename: R G
authors.initials: RG
authors.lastname: Cumming
mesh_terms: D004311:Double-Blind Method; D005260:Female; D006685:Hoarseness / Q000209:etiology*; D006801:Humans; D015994:Incidence; D007442:Intubation, Intratracheal / Q000009:adverse effects* / Q000379:methods; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000494:pharmacology; D017063:Outcome Assessment, Health Care; D010612:Pharyngitis / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology; D011312:Pressure
chemical_list: D009609:Nitrous Oxide