title: Early radiation effects on the liver demonstrated on superparamegnetic iron oxide-enhanced T1-weighted MRI.
abstract: Early radiation-induced liver injury during radiotherapy detected by a particulate reticuloendothelial MR contrast agent (superparamagnetic iron oxide; SPIO) is described in a patient with cholangiocarcinoma. The irradiated hepatic parenchyma appeared as a heterogeneous, less decreased signal intensity area than the nonirradiated area on MR images after SPIO administration. Resultant differences in signal intensity were better visualized on SPIO-enhanced T1-weighted images than SPIO-enhanced T2-weighted images, although SPIO-enhanced T2*-weighted fast field echo imaging was the most sensitive.
authors.affiliation: Department of Radiology, University of Tsukuba Hospital, Ibaraki, Japan. hmori-tky@umin.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Yoshioka
authors.forename: T
authors.initials: T
authors.lastname: Ahmadi
authors.forename: Y
authors.initials: Y
authors.lastname: Saida
authors.forename: K
authors.initials: K
authors.lastname: Ohara
authors.forename: Y
authors.initials: Y
authors.lastname: Itai
mesh_terms: D003287:Contrast Media / Q000378:metabolism; D003911:Dextrans; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007501:Iron / Q000378:metabolism; D008099:Liver / Q000033:anatomy & histology / Q000293:injuries / Q000528:radiation effects*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008875:Middle Aged; D010087:Oxides / Q000378:metabolism
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide