title: Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits.
abstract: OBJECTIVE
  To determine effects of conjugated linoleic acid (CLA) on establishment and progression of experimentally-induced atherosclerosis in rabbits.
  
  
  METHODS
  For establishment of atherosclerosis, New Zealand White rabbits were fed a semipurified diet containing 0.1% to 0.2% cholesterol for 90 days. Some groups were fed diet and CLA. For effects on progression of atherosclerosis, rabbits with established atherosclerosis were fed a semipurified diet +/- CLA for 90 days.
  
  
  RESULTS
  At dietary levels as low as 0.1%, CLA inhibited atherogenesis. At dietary levels of 1%, CLA caused substantial (30%) regression of established atherosclerosis. This is the first example of substantial regression of atherosclerosis being caused by diet alone.
  
  
  CONCLUSIONS
  Dietary CLA is an effective inhibitor of atherogenesis and also causes regression of established atherosclerosis.
authors.affiliation: The Wistar Institute, Philadelphia, Pennsylvania 19104, USA. kritchevsky@wistar.upenn.edu
authors.forename: D
authors.initials: D
authors.lastname: Kritchevsky
authors.forename: S A
authors.initials: SA
authors.lastname: Tepper
authors.forename: S
authors.initials: S
authors.lastname: Wright
authors.forename: P
authors.initials: P
authors.lastname: Tso
authors.forename: S K
authors.initials: SK
authors.lastname: Czarnecki
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D019787:Linoleic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008099:Liver / Q000737:chemistry; D008297:Male; D011817:Rabbits
chemical_list: D004042:Dietary Fats, Unsaturated; D008055:Lipids; D019787:Linoleic Acid