title: Prediction of viability by pulsed-wave Doppler tissue sampling of asynergic myocardium during low-dose dobutamine challenge.
abstract: Dobutamine stress echocardiography is widely used to predict reversible left ventricular dysfunction, but evaluation with this method is subjective. Pulsed-wave tissue Doppler imaging is a new technique that allows to obtain quantitative data on wall motion velocities of different myocardial segments through sample-volume placement. Therefore, this tool in combination with DSE may be suitable for identifying viability in asynergic myocardium. To evaluate this, in 40 patients (mean age 57+/-9) with resting dyssynergy (akinesis in 52, hypokinesis in 30) baseline wall motion scores and tissue Doppler variables were collected before and after 5 min infusion of 10 microg/kg per min dobutamine. Forty-six of 82 segments were classified as viable (a reduction in segmental score of at least one grade) according to follow-up echocardiography that was performed 4 weeks after revascularization. While myocardial S velocity percent increase in viable segments was 45+/-10, the increase was 25+/-12 in necrotic segments (n=36) during 10 microg dobutamine infusion (P=0.0001). Assuming 35% as a cut-off for viability the increase in S velocities by DSE yielded an 89% sensitivity and 86% specificity for predicting post-revascularization functional recovery. In conclusion, pulsed-wave tissue Doppler imaging of asynergic myocardium during dobutamine stress echocardiography can identify the viability quantitatively.
authors.affiliation: Cardiology Department, Maltepe University, Istanbul, Turkey. suata@superonline.com
authors.forename: S
authors.initials: S
authors.lastname: Altinmakas
authors.forename: B
authors.initials: B
authors.lastname: Dagdeviren
authors.forename: C
authors.initials: C
authors.lastname: Uyan
authors.forename: N
authors.initials: N
authors.lastname: Keser
authors.forename: V
authors.initials: V
authors.lastname: Gümüş
authors.forename: O
authors.initials: O
authors.lastname: Pektaş
mesh_terms: D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000628:therapy; D004280:Dobutamine; D004305:Dose-Response Relationship, Drug; D015150:Echocardiography, Doppler / Q000379:methods*; D005080:Exercise Test / Q000379:methods*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009204:Myocardial Revascularization; D011237:Predictive Value of Tests; D011300:Preoperative Care; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine