N-[1-(2-benzo[b]thiophenyl)Cyclohexyl]- piperidine (BTCP) exerts cocaine-like actions on drug-maintained responding in rats.
The effects of N-[1-(2-benzo[b]thiophenyl)cyclohexyl]- piperidine (BTCP), a phencyclidine derivative that acts as a potent dopamine reuptake inhibitor, were examined on cocaine self-administration in rats. The effects of BTCP (0, 4, 8, 16, and 32 mg/kg, i.p.) on cocaine self-administration were tested against cocaine doses on both the ascending (0.0625 mg/infusion) and descending (0.25 mg/infusion) limb of the dose-response function. BTCP decreased self-administration of the 0.25-mg cocaine dose in a dose-dependent manner. A 16-mg/kg dose of BTCP that strongly suppressed self-administration of the 0.25-mg cocaine dose increased the intake at the 0.0625-mg dose of cocaine. Moreover, cocaine and BTCP pretreatments produced similar patterns of decreases in self-administration of cocaine on the descending limb of the dose-response function. The results suggest that BTCP has cocaine-like actions and produces a leftward shift of the dose-response curve for cocaine self-administration, indicating that the phencyclidine analog may substitute under certain conditions for the reinforcing effects of cocaine in self-administering rats.
Martin-Fardon
R
R
Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA.
Weiss
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F
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D010622:Phencyclidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012054:Reinforcement, Psychology; D012646:Self Administration; D019966:Substance-Related Disorders / Q000523:psychology*
D018491:Dopamine Agonists; D018765:Dopamine Uptake Inhibitors; C056415:1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine; D003042:Cocaine; D010622:Phencyclidine