title: Age of onset, not type of onset, affects the positivity and evanescence of IA-2 antibody.
abstract: Autoantibody against IA-2 (IA-2A) was found to be discordant with autoantibody against glutamic acid decarboxylase (GADA) with respect to both positivity and titer in Japanese, the same as in Caucasians. In this study, 247 type 1 diabetic patients were tested in order to clarify how the type of onset, age of onset, and duration of diabetes affect the frequency and evanescence of IA-2A. Among the young onset patients, the frequency of IA-2A was higher (52.2%), but evanescent (54.5, 66.7 and 36.7% in the insulin therapy duration < or =1, 2-5 years, and > or =6 years groups, respectively), whereas among adult onset patients, the frequency was lower (19.3%) but persistent (19.6, 13.3 and 23.5%, respectively). In addition, in the follow-up study, two of three IA-2A-positive young onset patients converted to negative in only three years, while all five adult onset patients remained positive for over 5 years. Among the adult onset patients, IA-2A frequency was similar in the slowly progressive type and the abrupt onset type. In view of the above findings, IA-2A positivity and evanescence in type 1 diabetic patients appear to be affected by age of onset, not type of onset.
authors.affiliation: Department of Internal Medicine, Mito Red Cross Hospital, 3-12-48, Sannomaru, Mito-city, 310-0011, Ibaraki, Japan. juliano@ja2.so-net.ne.jp
authors.forename: S
authors.initials: S
authors.lastname: Nakamoto
authors.forename: A
authors.initials: A
authors.lastname: Kasuga
authors.forename: T
authors.initials: T
authors.lastname: Maruyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ozawa
authors.forename: S
authors.initials: S
authors.lastname: Amemiya
authors.forename: T
authors.initials: T
authors.lastname: Saruta
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000276:immunology; D007564:Japan; D008297:Male; D008875:Middle Aged; D044465:White People
chemical_list: D001323:Autoantibodies; D007527:Isoenzymes; C024211:islet cell antibody; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2