Deletion 7p in gastric MALT lymphoma.
Deletion of the long arm of chromosome 7 has been related to loss of tumor suppressor genes which may constitute a primary step of carcinogenesis in many kinds of malignancies, including low-grade B-cell lymphoma. However, deletion of the short arm of chromosome 7, del(7p), in low-grade B-cell lymphoma has not been reported. Here, we report a case of gastric MALT lymphoma with the chromosome aberration del(7p) which progressed in spite of eradication of Helicobactor pylori. Deletion 7p may represent a new karyotypic change that is possibly related to autonomous growth of MALT lymphoma.
Katayama
Y
Y
Department of Internal Medicine, Kobe West City Hospital, Kobe, Japan.
Kirizuka
K
K
Nishizaki
H
H
Nakamoto
Y
Y
Yamamoto
M
M
Kohriyama
K
K
D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D018450:Disease Progression; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D007621:Karyotyping; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology / Q000473:pathology