Linkage exclusion analysis of the chromosome 11 region containing UCP2 and UCP3 with obesity-related phenotypes in Mexican Americans.
OBJECTIVE
To investigate whether the region of chromosome 11 (11q13) containing the genes UCP2 and UCP3 could be excluded for linkage with a variety of obesity-related phenotypes in humans.


METHODS
Exclusion mapping using a variance component approach in extended pedigrees.


METHODS
Four-hundred and fifty eight individuals (195 females, 263 males) distributed in 10 Mexican American families of probands randomly ascertained with respect to any disease state and who are participating in the San Antonio Family Heart Study. Ages range from 18 to 87 (mean age 35 y).


METHODS
Serum leptin levels, fat mass (FM), body mass index (BMI), and waist circumference.


RESULTS
We were able to exclude the chromosomal region containing UCP2/UCP3 as having an effect on this set of obesity-related phenotypes at relative effect sizes of 10% or greater (P-values<0.05).


CONCLUSIONS
These results suggest that variation in these genes is unlikely to have a substantial effect on the expression of obesity-related phenotypes in the Mexican American population.
Comuzzie
A G
AG
Southwest Foundation for Biomedical Research, San Antonio, Texas, USA. agcom@darwin.sfbr.org
Almasy
L
L
Cole
S A
SA
Boss
O
O
Giacobino
J P
JP
Muzzin
P
P
Stern
M P
MP
MacCluer
J W
JW
Blangero
J
J
Hixson
J E
JE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000886:Anthropometry; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D007473:Ion Channels; D020738:Leptin / Q000097:blood; D008297:Male; D026901:Membrane Transport Proteins; D017058:Mexican Americans / Q000235:genetics*; D008875:Middle Aged; D024101:Mitochondrial Proteins; D009765:Obesity / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D011506:Proteins / Q000235:genetics*; D013781:Texas; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3; D044465:White People / Q000235:genetics*
D002352:Carrier Proteins; D007473:Ion Channels; D020738:Leptin; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; C000604389:UCP2 protein, human; C000604392:UCP3 protein, human; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3