title: Regioselective synthesis of 1,3,5-triaryl-4-alkylpyrazoles: novel ligands for the estrogen receptor.
abstract: [reaction: see structure] A regioselective synthesis of 4-alkyl-1,3,5-triarylpyrazoles has been developed for the preparation of unsymmetrically substituted systems of interest as ligands for the estrogen receptor.
authors.affiliation: Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA.
authors.forename: Y R
authors.initials: YR
authors.lastname: Huang
authors.forename: J A
authors.initials: JA
authors.lastname: Katzenellenbogen
mesh_terms: D007536:Isomerism; D008024:Ligands; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D020845:Selective Estrogen Receptor Modulators / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: D008024:Ligands; D011720:Pyrazoles; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators