title: Anti-inflammatory evaluation of Ficus racemosa Linn. leaf extract.
abstract: The anti-inflammatory activity of Ficus racemosa extract was evaluated on carrageenin, serotonin, histamine and dextran-induced rat hind paw oedema models. The extract at doses of 200 and 400 mg/kg has been found to possess significant anti-inflammatory activity on the tested experimental models. The extract (400 mg/kg) exhibited maximum anti-inflammatory effect, that is 30.4, 32.2, 33.9 and 32.0% at the end of 3 h with carrageenin, serotonin, histamine, dextran-induced rat paw oedema, respectively. In a chronic test the extract (400 mg/kg) showed 41.5% reduction in granuloma weight. The effect produced by the extract was comparable to that of phenylbutazone, a prototype of a non-steroidal anti-inflammatory agent.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta 700 032, India.
authors.forename: S C
authors.initials: SC
authors.lastname: Mandal
authors.forename: T K
authors.initials: TK
authors.lastname: Maity
authors.forename: J
authors.initials: J
authors.lastname: Das
authors.forename: B P
authors.initials: BP
authors.lastname: Saba
authors.forename: M
authors.initials: M
authors.lastname: Pal
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D005528:Foot / Q000473:pathology; D006099:Granuloma / Q000473:pathology; D006632:Histamine; D007194:India; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D010936:Plant Extracts; D012701:Serotonin; D006632:Histamine; D002351:Carrageenan; D010653:Phenylbutazone