Effects of atrial natriuretic peptide in the gut.
The intestinal tract is a target organ for atrial natriuretic peptide (ANP), characterized by various biologic activities, immunoreactivity, as well as specific binding sites for ANP. A review of previous studies reveals that ANP is an important regulator of water and nutrient intake, which acts via multiple signaling pathways including activation of guanylyl cyclase to produce its biologic responses. As a regulator, the peptide locally controls hydrosaline balance and acute systemic effects. Therefore, ANP could also act as a local mediator or paracrine effector of intestinal function.
González Bosc
L V
LV
Cátedra de Biología Celular e Histología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires. Junin 956, 1er piso (1113), Buenos Aires, Argentina. lgbosc@ffyb.uba.ar
Majowicz
M P
MP
Vidal
N A
NA
D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D004064:Digestive System / Q000187:drug effects*; D020895:Enterocytes / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects; D007422:Intestines / Q000187:drug effects*; D008954:Models, Biological; D015398:Signal Transduction
D009320:Atrial Natriuretic Factor