title: CT-Guided acetic acid injection therapy for aldosterone-producing adrenocortical adenoma: a preliminary report of three cases.
abstract: We reported the preliminary outcomes of CT-guided percutaneous injection therapy for aldosterone-producing adrenocortical adenoma (APA). Five sessions of injection therapy, 4 percutaneous acetic acid injections (PAI) and 1 percutaneous ethanol injection (PEI) were performed in 3 patients with APA. A small amount of acetic acid or ethanol solution was injected via a needle placed precisely inside the tumor. The procedure was frequently monitored by repetitive CT scanning. The follow-up period ranged from 5 to 27 months. After the treatment, hypertension was normalized or controlled by a low dose of conventional anti-hypertensive drug. In 2 of 3 cases the plasma aldosterone levels were normalized. Although temporary symptoms of alcoholic intoxication were observed in the single session of PEI, the 4 sessions of PAI were associated with no adverse symptoms or complications. Although this study covers only short-term results in 3 patients, CT-guided PAI appears to be a safe and effective treatment and may be a promising alternative as a simple and far less invasive therapy for APA.
authors.affiliation: Department of Urology, Faculty of Medicine, The University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Minowada
authors.forename: Y
authors.initials: Y
authors.lastname: Enomoto
authors.forename: T
authors.initials: T
authors.lastname: Korenaga
authors.forename: T
authors.initials: T
authors.lastname: Kamijo
authors.forename: Y
authors.initials: Y
authors.lastname: Homma
authors.forename: T
authors.initials: T
authors.lastname: Kitamura
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D000236:Adenoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000450:Aldosterone / Q000096:biosynthesis* / Q000097:blood; D001794:Blood Pressure; D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000431:Ethanol; D000450:Aldosterone; D019342:Acetic Acid