Angiotensin-(1-7): an update.
The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis processing of angiotensinogen, are importantly involved in mediating several actions of the RAS. In this article we will review our knowledge of the biological actions of Ang-(1-7) with focus on the puzzling aspects of the mediation of its effects and the interaction Ang-(1-7)-kinins. In addition, we will attempt to summarize the evidence that Ang-(1-7) takes an important part of the mechanisms aimed to counteract the vasoconstrictor and proliferative effects of Ang II.
Santos
R A
RA
Departamento de Fisiologia e Biofísica, Av. Antonio Carlos, 6627 - Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG Brazil. marrob@dedalus.lcc.ufmg.br
Campagnole-Santos
M J
MJ
Andrade
S P
SP
D000803:Angiotensin I; D000804:Angiotensin II / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001808:Blood Vessels / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism; D019808:Losartan / Q000494:pharmacology; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism / Q000502:physiology*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D011485:Protein Binding; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000378:metabolism; D015398:Signal Transduction; D014661:Vasoconstriction / Q000502:physiology
D010446:Peptide Fragments; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A; C118790:angiotensin I (1-7); D019808:Losartan