Spontaneous regression of vulvar intraepithelial neoplasia 2-3.
OBJECTIVE
To determine the background and clinical features of a group of women who experienced spontaneous regression of vulvar intraepithelial neoplasia (VIN) 2-3 before treatment was undertaken.


METHODS
A retrospective review was made of the records of 14 women who experienced spontaneous regression of VIN 2-3.


RESULTS
The women were 15-27 years of age (median 19.5 years). Ninety-three percent were non-white. All women were seen initially in a sexual health clinic, and with one exception, all had been treated previously for genital condyloma acuminata. Four of the 14 cases were pregnancy-associated. Half of the women were asymptomatic. The transit time to regression of VIN 2-3 was 3-30 months (median 9.5 months). The median follow-up was 3 years. All lesions were multiple and pigmented.


CONCLUSIONS
Spontaneous regression of VIN 2-3 can occur in young women with multifocal pigmented lesions.
Jones
R W
RW
Vulvar Clinic, Department of Gynecologic Oncology, National Women's Hospital, Auckland, New Zealand.
Rowan
D M
DM
D000293:Adolescent; D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology*; D003218:Condylomata Acuminata / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009365:Neoplasm Regression, Spontaneous; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology*