title: Diagnosis and management of supra-esophageal complications of reflux disease.
abstract: Supra-esophageal reflux disease may be manifested in numerous ways, including reflux laryngitis, chronic cough, chronic sinusitis, and dental enamel loss. The mechanisms of pharyngeal and laryngeal reflux are not clearly defined, and standard reflux testing does not consistently demonstrate supra-esophageal reflux. The diagnosis is usually based on clinical suspicion when other causes of symptoms are not found and on the patient's response to empiric acid suppression. With the development of triple-probe pH monitoring, through which pharyngeal pH can be assessed along with esophageal pH, the physician may now be able to demonstrate pharyngeal reflux in relation to patient symptoms. Therapy consists primarily of behavioral modification and aggressive acid suppression, although some alternative therapies exist.
authors.affiliation: Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor 48109-0362, USA. tnostran@po-02.intmed1
authors.forename: T T
authors.initials: TT
authors.lastname: Nostrant
authors.forename: J C
authors.initials: JC
authors.lastname: Rabine
mesh_terms: D000465:Algorithms; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003371:Cough / Q000209:etiology*; D016099:Endoscopy, Gastrointestinal; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000517:prevention & control*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007827:Laryngitis / Q000209:etiology*; D007828:Laryngoscopy; D008991:Monitoring, Physiologic; D012852:Sinusitis / Q000209:etiology*; D014077:Tooth Erosion / Q000209:etiology*
chemical_list: D000897:Anti-Ulcer Agents