title: Substance P.
abstract: Substance P is considered to be an important neuropeptide in nociceptive processes. Although substance P was described more than 60 years ago, there is still controversy about its exact role in nociception. This article reviews the current knowledge about the function of substance P in pain. Special emphasis is put on how to use this knowledge in the development of new ways to treat pain.
authors.affiliation: Department of Anesthesiology/Pain Center, University Hospital, Nijmegen, The Netherlands. dik.snijdelaar@usa.net
authors.forename: D G
authors.initials: DG
authors.lastname: Snijdelaar
authors.forename: R
authors.initials: R
authors.lastname: Dirksen
authors.forename: R
authors.initials: R
authors.lastname: Slappendel
authors.forename: B J
authors.initials: BJ
authors.lastname: Crul
mesh_terms: D002490:Central Nervous System / Q000737:chemistry / Q000502:physiology; D006801:Humans; D010146:Pain / Q000503:physiopathology*; D013373:Substance P / Q000502:physiology*
chemical_list: D013373:Substance P