title: Cytosensor techniques for examining signal transduction of neurohormones.
abstract: This review describes the principles of microphysiometry and how they can be applied, using the Cytosensor, to the investigation of the signal transduction mechanisms activated by both G-protein and non-G-protein coupled hormone and neuropeptide receptors. The use of the Cytosensor to study desensitisation and cross-talk is also discussed, as are the benefits and limitations of this technique.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Neuroscience Research, Harlow, Essex, UK.
authors.forename: D
authors.initials: D
authors.lastname: Smart
authors.forename: M D
authors.initials: MD
authors.lastname: Wood
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation; D002460:Cell Line; D019204:GTP-Binding Proteins / Q000378:metabolism; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008024:Ligands; D009479:Neuropeptides / Q000378:metabolism; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D006728:Hormones; D008024:Ligands; D009479:Neuropeptides; D019204:GTP-Binding Proteins