Plasmodium falciparumin the squirrel monkey (Saimiri sciureus): infection of non-splenectomised animals as a model for exploring clinical manifestations of malaria.
Plasmodium falciparum infection in humans leads to a variety of symptoms ranging from an influenza-like syndrome to life-threatening complications. Animal models are useful tools for the detailed analysis of the interaction between both parasite and host factors leading to these various clinical manifestations. In this review, examining the different clinical, parasitological and haematological parameters associated with P. falciparum infection in spleen-intact monkeys, we propose this model as a good alternative for exploring some aspects of the host-parasite relationship in malaria.
Contamin
H
H
Laboratoire d'immunologie parasitaire et centre de primatologie, Institut Pasteur de la Guyane, Cayenne, French Guiana.
Behr
C
C
Mercereau-Puijalon
O
O
Michel
J
J
D000740:Anemia / Q000469:parasitology; D000818:Animals; D004195:Disease Models, Animal; D005334:Fever / Q000469:parasitology; D006402:Hematologic Diseases / Q000469:parasitology; D006801:Humans; D007962:Leukocytes / Q000166:cytology; D016778:Malaria, Falciparum / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D010963:Plasmodium falciparum / Q000502:physiology; D012453:Saimiri; D013154:Spleen / Q000276:immunology; D013156:Splenectomy; D013921:Thrombocytopenia / Q000469:parasitology