title: Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines.
abstract: 5-(2-Phenyl-3'-indolal)-2-thiohydantoin (PIT) has been evaluated as an anti-cancer compound on several cancer lines organised in to subpanels representing leukemia, melanoma, and cancer of lung, colon, kidney, ovary, breast, prostate and central nervous system by the National Cancer Institute (NCI) anti-cancer drug screen programme. The compound showed inhibitory activity on several cancer cell lines. No information is available on anti-cancer potency of this compound with normal cell lines.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy (ECZACILIK), Ankara University, Turkey. sibel@pharmacy.ankara.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Suzen
authors.forename: E
authors.initials: E
authors.lastname: Buyukbingol
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D010669:Phenylthiohydantoin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: C418562:5-(2-phenyl-3'-indolal)-2-thiohydantoin; D000970:Antineoplastic Agents; D010669:Phenylthiohydantoin