title: Cardiac valve replacement in patients on dialysis: influence of prosthesis on survival.
abstract: BACKGROUND
  Mechanical valves have been recommended for patients on dialysis because of purported accelerated bioprosthesis degeneration. This study was undertaken to determine time-related outcomes in dialysis patients requiring cardiac valve replacement.
  
  
  METHODS
  From 1986 to 1998, 42 patients on chronic preoperative dialysis underwent valve replacement; 17 received mechanical valves and 25 received bioprostheses. Age was similar in both groups: 54+/-18.5 years (mechanical) and 59+/-15.5 years (bioprosthetic, p = 0.4). Sites of valve replacement were aortic (27), mitral (11), and aortic and mitral (4). Follow-up was 100% complete.
  
  
  RESULTS
  Survival at 3 and 5 years was 50% and 33% after mechanical valve replacement, and 36% and 27% after bioprosthetic valve replacement (p = 0.3). Four patients with bioprostheses required reoperation: 3 for allograft endocarditis and 1 at 10 months for mitral bioprosthesis degeneration. One patient who received a mechanical valve required reoperation.
  
  
  CONCLUSIONS
  Prosthetic valve-related complications in patients on dialysis were similar for both mechanical and bioprosthetic valves. Because of the limited life expectancy of patients on dialysis, bioprosthesis degeneration will be uncommon. Therefore, surgeons should not hesitate to implant bioprosthetic valves in these patients.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Kaplon
authors.forename: D M
authors.initials: DM
authors.lastname: Cosgrove
authors.forename: A M
authors.initials: AM
authors.lastname: Gillinov
authors.forename: B W
authors.initials: BW
authors.lastname: Lytle
authors.forename: E H
authors.initials: EH
authors.lastname: Blackstone
authors.forename: N G
authors.initials: NG
authors.lastname: Smedira
mesh_terms: D000328:Adult; D001705:Bioprosthesis; D015897:Comorbidity; D006349:Heart Valve Diseases / Q000453:epidemiology / Q000601:surgery; D006350:Heart Valve Prosthesis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000628:therapy; D008875:Middle Aged; D011474:Prosthesis Design; D006435:Renal Dialysis; D016019:Survival Analysis