title: Presumed laryngo-pharyngeal reflux: investigate or treat?
abstract: A review of a combined gastroenterology and laryngology clinic was conducted to determine the effectiveness of treatment and the predictive value of clinical findings and investigations. Data were collected prospectively. Investigations were performed according to clinical criteria. Patients with symptoms suspected to be due to laryngopharyngeal reflux (based on a positive oesophageal pH test and/or changes on videolaryngoscopy consistent with posterior laryngitis) were treated with omeprazole for at least two to three months. There were 87 patients; the most common symptoms were cough (38 per cent) and hoarseness (36 per cent); 77 per cent had some symptoms suggestive of gastro-oesophageal reflux. Sixty-seven patients were given omeprazole. A good response to laryngo-pharyngeal symptoms was seen in 37 patients (55 per cent). The presence of reflux symptoms was not a predictor of a good response. Increasing severity of oesophageal acid exposure over the 24 hours of pH testing was associated with a better symptom response (Spearman rank correlation, p = 0.01). Posterior laryngitis was not associated with the response to treatment, although there was a trend towards an association between improvement in laryngitis (after treatment) and improvement in symptoms (p = 0.08). The response to proton pump inhibitors was lower than other published results. Oesophageal pH monitoring may have a role in predicting which patients will respond to proton pump inhibitors. This study does not support the decision to treat with anti-secretory therapy, based only on the presence of posterior laryngitis.
authors.affiliation: Department of Medicine, University of Auckland, New Zealand.
authors.forename: A G
authors.initials: AG
authors.lastname: Fraser
authors.forename: R P
authors.initials: RP
authors.lastname: Morton
authors.forename: J
authors.initials: J
authors.lastname: Gillibrand
mesh_terms: D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D002985:Clinical Protocols; D003937:Diagnosis, Differential; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D007827:Laryngitis / Q000150:complications; D007828:Laryngoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D010608:Pharyngeal Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D011446:Prospective Studies
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole