Relatedness testing in subdivided populations.
Assigning probabilities to alleged relationships, given DNA profiles, requires, among other things, calculation of a likelihood ratio (LR). Such calculations usually assume independence of genes: this assumption is not appropriate when the tested individuals share recent ancestry due to population substructure. Adjusted LR formulae, incorporating the coancestry coefficient F(ST), are presented here for various two-person relationships, and the issue of mutations in parentage testing is also addressed.
Ayres
K L
KL
Department of Applied Statistics, University of Reading, P.O. Box 240, Earley Gate, RG6 6FN, Reading, UK. k.l.ayres@reading.ac.uk
D005190:Family; D005260:Female; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D009154:Mutation; D010334:Paternity