Prolonged neuromuscular block with mivacurium in a patient with cholinesterase deficiency.
Mivacurium is a short-acting, nondepolarizing neuromuscular blocking agent hydrolyzed by plasma cholinesterase. Because it allows fast recovery, it is a commonly used muscle relaxant for patients undergoing short surgical procedures. We report the case of a 5-year-old boy who underwent outpatient inguinal herniorraphy and developed unexpected prolonged neuromuscular block after the use of mivacurium. He required mechanical ventilation support in the intensive care unit because he could not attain adequate muscle power 1 hour after termination of anesthesia; the muscular paralysis persisted for 5 hours after the bolus dose of 0.3 mg/kg mivacurium. Subsequent investigation revealed an extremely low plasma cholinesterase concentration (115 U/L), and this was later determined to be a congenital condition. This is the first reported case of cholinesterase deficiency diagnosed as a result of general anesthesia in Taiwan.
Wong
T K
TK
Department of Anesthesiology, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Taoyuan, Taiwan.
Chen
C
C
Liou
S C
SC
Lee
Y H
YH
Huang
C S
CS
D002675:Child, Preschool; D002802:Cholinesterases / Q000172:deficiency*; D006801:Humans; D007546:Isoquinolines / Q000009:adverse effects*; D008297:Male; D000077590:Mivacurium; D009469:Neuromuscular Junction / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D013997:Time Factors
D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002802:Cholinesterases