title: Signal transduction mechanisms mediating secretion in goldfish gonadotropes and somatotropes.
abstract: The intracellular signal transduction mechanisms mediating maturational gonadotropin and somatotropin secretion in goldfish are reviewed. Several major signaling mechanisms, including changes in intracellular [Ca2+], arachidonic acid cascades, protein kinase C, cyclic AMP/protein kinase A, calmodulin, nitric oxide, and Na+/H+ antiport, are functional in both cell types. However, their relative importance in mediating basal secretion and neuroendocrine-factor-regulated hormone release differs according to cell type. Similarly, agonist- and cell-type-specificity are also present in the transduction pathways leading to neuroendocrine factor-modulated maturational gonadotropin and somatotropin release. Specificity is present not only in the actions of different regulators within the same cell type and with the same ligand in the two cell types, but this also exists between isoforms of the same neuroendocrine factor within a single cell type. Other evidence suggests that function-selectivity of signaling may also result from differential modulation of Ca2+ fluxes from different sources. The interaction of different second messenger systems provide the basis by which regulation of maturational gonadotropin and somatotropin release by multiple neuroendocrine factors can be integrated at the target cell level.
authors.affiliation: Department of Biological Sciences, University of Alberta, Edmonton, Canada. john.chang@ualberta.ca
authors.forename: J P
authors.initials: JP
authors.lastname: Chang
authors.forename: J D
authors.initials: JD
authors.lastname: Johnson
authors.forename: F
authors.initials: F
authors.lastname: Van Goor
authors.forename: C J
authors.initials: CJ
authors.lastname: Wong
authors.forename: W K
authors.initials: WK
authors.lastname: Yunker
authors.forename: A D
authors.initials: AD
authors.lastname: Uretsky
authors.forename: D
authors.initials: D
authors.lastname: Taylor
authors.forename: R M
authors.initials: RM
authors.lastname: Jobin
authors.forename: A O
authors.initials: AO
authors.lastname: Wong
authors.forename: J I
authors.initials: JI
authors.lastname: Goldberg
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism* / Q000502:physiology; D006062:Gonadotropins / Q000378:metabolism*; D013006:Growth Hormone / Q000378:metabolism*; D008024:Ligands; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism; D020033:Protein Isoforms; D011493:Protein Kinase C / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D006062:Gonadotropins; D008024:Ligands; D020033:Protein Isoforms; D016718:Arachidonic Acid; D009569:Nitric Oxide; D013006:Growth Hormone; D000242:Cyclic AMP; D011493:Protein Kinase C; D002118:Calcium