title: Determination of absolute configurations of amines and amino acids using nonchiral derivatizing agents (NCDA) and deuterium NMR.
abstract: Enantiomeric analysis and empirical determination of the absolute configuration of amines and amino acids can be easily performed using acetyl-d(3) chloride as a nonchiral derivatizing agent (deuterium probe) and deuterium NMR in a chiral solvent (Courtieu's method). In the case of amino acids, derivatization to amido esters, performed with methanol-d(4) and acetyl-d(3) chloride, gives a double opportunity for enantiomeric analysis.
authors.affiliation: Laboratoire SEESIB, UMR CNRS 6504, Université Blaise Pascal, 63177 Aubière Cedex, France. icanet@chimtp@univ-bpclermont.fr
authors.forename: P
authors.initials: P
authors.lastname: Chalard
authors.forename: M
authors.initials: M
authors.lastname: Bertrand
authors.forename: I
authors.initials: I
authors.lastname: Canet
authors.forename: V
authors.initials: V
authors.lastname: Théry
authors.forename: R
authors.initials: R
authors.lastname: Remuson
authors.forename: G
authors.initials: G
authors.lastname: Jeminet
mesh_terms: D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002918:Chymotrypsin; D003903:Deuterium; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000588:Amines; D000596:Amino Acids; D007202:Indicators and Reagents; D003903:Deuterium; D002918:Chymotrypsin