Identification of a chemical tool for the orphan nuclear receptor FXR.
Maloney
P R
PR
Department of Medicinal Chemistry, Glaxo Wellcome Research & Development, Research Triangle Park, North Carolina 27709, USA. prm8279@glaxowellcome.com
Parks
D J
DJ
Haffner
C D
CD
Fivush
A M
AM
Chandra
G
G
Plunket
K D
KD
Creech
K L
KL
Moore
L B
LB
Wilson
J G
JG
Lewis
M C
MC
Jones
S A
SA
Willson
T M
TM
D000818:Animals; D001682:Biological Availability; D002460:Cell Line; D002474:Cell-Free System; D020650:Combinatorial Chemistry Techniques; D004268:DNA-Binding Proteins / Q000819:agonists*; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists*; D014162:Transfection; D014280:Triglycerides / Q000097:blood; D000099150:Receptor, Farnesoid X-Activated
D004268:DNA-Binding Proteins; D007555:Isoxazoles; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014280:Triglycerides; D000099150:Receptor, Farnesoid X-Activated; C412815:GW 4064