title: Incidence of myocardial infarctions in HIV-infected patients between 1983 and 1998: the Frankfurt HIV-cohort study.
abstract: OBJECTIVE
  To investigate whether the use of highly active antiretroviral therapy (HAART) is associated with an increased incidence of myocardial infarctions (MI) in HIV infected patients.
  
  
  METHODS
  Retrospective analysis of a cohort of 4993 HIV infected patients treated at our hospital between January, 1 1983 and December, 31 1998. The incidence of myocardial infarctions during 4 observation periods with different antiretroviral treatment strategies are compared. Possible risk factors for MI are evaluated by univariate analysis and using a multiple regression model.
  
  
  RESULTS
  29 patients with MI were diagnosed between 1983 and 1998. The incidence of MI per 1000 patient-years increased from 0.86 (1983-86), 1.14 (1987-90), 0.59 (1991-94) to 3.41 (1995-98) respectively (p = 0.002). Age >40, previous HAART therapy, homo-, or bisexual mode of HIV transmission and previous AIDS diagnosis were significantly associated with MI in univariate analysis. Age >40 and previous HAART therapy remained significantly associated with MI in a multiple regression model.
  
  
  CONCLUSIONS
  The incidence of MI in HIV infected patients increased in our cohort after the introduction of HAART.
authors.affiliation: Klinikum der J.W. Goethe Universität Frankfurt, Med. Klinik III / Infektiologie, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany. Rickerts@em.uni-frankfurt.de
authors.forename: V
authors.initials: V
authors.lastname: Rickerts
authors.forename: H
authors.initials: H
authors.lastname: Brodt
authors.forename: S
authors.initials: S
authors.lastname: Staszewski
authors.forename: W
authors.initials: W
authors.lastname: Stille
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D019380:Anti-HIV Agents