Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia.
OBJECTIVE
to evaluate the plasma IL-10 levels during elective operative repair of thoraco-abdominal and abdominal aortic aneurysm repair. To study whether IL-10 plasma levels are associated with the duration of cross-clamping (ischaemia) and clinical outcome.


METHODS
fifteen consecutive patients undergoing surgery for TAAA and 10 consecutive patients undergoing surgical repair of AAA were included.


METHODS
plasma concentrations of IL-10 were measured by ELISA technique. Clinical outcome of the TAAA patients was prospectively analysed.


RESULTS
during aortic clamping IL-10 was produced in both populations. The plasma IL-10 peak (934+/-172 pg/ml) of the TAAA group was seen at 4 h after declamping and remained detectable after 48 h. The plasma IL-10 peak (212+/-32 pg/ml) of the AAA group was seen 30 min after declamping and fell to undetectable levels by 24 h. These data show that the peak IL-10 plasma levels in TAAA repair are significantly (p<0.05) higher compared to the peak IL-10 plasma levels as seen during AAA repair. A positive correlation was seen between cross-clamping and peak plasma IL-10 and organ dysfunction.


CONCLUSIONS
IL-10 plasma concentrations appear higher, later and are longer detectable in patients undergoing TAAA. Correlations were seen with duration of cross-clamping and MSOD.
Oldenburg
H S
HS
Department of Surgery, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Burress Welborn
M
M
Pruitt
J H
JH
Boelens
P G
PG
Seeger
J M
JM
Martin
T D
TD
Wesdorp
R I
RI
Rauwerda
J A
JA
van Leeuwen
P A
PA
Moldawer
L L
LL
D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D003250:Constriction; D004797:Enzyme-Linked Immunosorbent Assay; D006402:Hematologic Diseases / Q000097:blood / Q000209:etiology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D007431:Intraoperative Complications / Q000097:blood* / Q000209:etiology* / Q000276:immunology; D007674:Kidney Diseases / Q000097:blood / Q000209:etiology; D008107:Liver Diseases / Q000097:blood / Q000209:etiology; D008171:Lung Diseases / Q000097:blood / Q000209:etiology; D016343:Monitoring, Intraoperative; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology; D011446:Prospective Studies; D015427:Reperfusion Injury / Q000097:blood* / Q000209:etiology* / Q000276:immunology; D013997:Time Factors; D016896:Treatment Outcome; D014781:Viscera / Q000098:blood supply*
D016753:Interleukin-10