title: The first regioselective alpha-deprotonation and functionalization of allenamides. An application in intramolecular Pauson-Khand-type cycloadditions.
abstract: [rection: see text] The first regioselective alpha-deprotonation and functionalization of electron-deficient allenamines are described here. The acidities of alpha- and gamma-allenic protons of these allenamides are readily differentiated using strong bases, thereby allowing regioselective substitutions at either the alpha- or gamma-allenic position. A specific synthetic application of the novel alpha-substituted allenamides in intramolecular Pauson-Khand-type cycloadditions is also described here.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: H
authors.initials: H
authors.lastname: Xiong
authors.forename: R P
authors.initials: RP
authors.lastname: Hsung
authors.forename: L L
authors.initials: LL
authors.lastname: Wei
authors.forename: C R
authors.initials: CR
authors.lastname: Berry
authors.forename: J A
authors.initials: JA
authors.lastname: Mulder
authors.forename: B
authors.initials: B
authors.lastname: Stockwell