Anti-toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro.
The anti-Toxoplasma activities of nine antiretroviral drugs were examined in vitro. Nucleoside analogs had no effect on parasite growth, whereas ritonavir and nelfinavir were inhibitory for Toxoplasma, with 50% inhibitory concentrations of 5.4 and 4.0 microg/ml, respectively. None of the antiviral drugs affected the anti-Toxoplasma activity of pyrimethamine or sulfadiazine.
Derouin
F
F
Laboratoire de Parasitologie-Mycologie, Faculté de Médecine-Hôpital Saint-Louis, Paris, France. paracord@wanadoo.fr
Santillana-Hayat
M
M
D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology; D003049:Coccidiostats / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D019888:Nelfinavir / Q000494:pharmacology; D011739:Pyrimethamine / Q000494:pharmacology*; D019438:Ritonavir / Q000494:pharmacology; D013411:Sulfadiazine / Q000494:pharmacology*; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development
D019380:Anti-HIV Agents; D000981:Antiprotozoal Agents; D003049:Coccidiostats; D013411:Sulfadiazine; D019888:Nelfinavir; D019438:Ritonavir; D011739:Pyrimethamine