Increased oxidative stress in kwashiorkor.
To test the hypothesis that kwashiorkor is associated with increased oxidative stress, urinary concentrations of 2 oxidized amino acids, o,o '-dityrosine and ortho -tyrosine, were measured by gas chromatography-mass spectrometry. Children with kwashiorkor, with or without infection, had a 3- to 7-fold increase in urinary o,o '-dityrosine and a 1.5- to 2-fold increase in ortho -tyrosine when compared with well-nourished children. This observation raises the possibility that oxidative damage to proteins and other biologic targets plays a role in the clinical manifestations of kwashiorkor.
Manary
M J
MJ
Department of Pediatrics, St Louis Children's Hospital, St Louis, Missouri 63110, USA.
Leeuwenburgh
C
C
Heinecke
J W
JW
D002675:Child, Preschool; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007239:Infections / Q000150:complications; D007536:Isomerism; D007732:Kwashiorkor / Q000150:complications / Q000503:physiopathology* / Q000652:urine; D008297:Male; D018384:Oxidative Stress / Q000502:physiology*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000652:urine
D014443:Tyrosine; C026741:2-tyrosine; C007543:dityrosine