title: Drug treatment of non-variceal upper gastrointestinal bleeding.
abstract: Despite many clinical investigations, proof is lacking that pharmacological treatments significantly influence the outcome in non-variceal upper gastrointestinal bleeding. Reaching conclusions has been hindered by the small size of many studies in a situation in which a large number of patients must be included if confident conclusions are to be reached. In addition, many studies, by comparing two potentially active treatments without a placebo group, have been unable to determine whether an equivalence of the active treatments represents equivalent but active or equivalent but inactive therapy.
authors.affiliation: Department of Medicine, University of Birmingham, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Langman
mesh_terms: D003937:Diagnosis, Differential; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D004932:Esophageal and Gastric Varices / Q000175:diagnosis; D006490:Hemostatics / Q000627:therapeutic use*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000188:drug therapy*; D054328:Proton Pump Inhibitors; D013276:Stomach Ulcer / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D004791:Enzyme Inhibitors; D006490:Hemostatics; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors