title: Use of the bisphosphonate drug alendronate for palliative management of osteosarcoma in two dogs.
abstract: The bisphosphonate drug alendronate was used to suppress bone remodelling and tumour osteolysis as a palliative treatment for two dogs with osteosarcoma, one of the tibia and one of the maxilla. A spiral fracture associated with the tibial tumour healed after it was stabilised with an external skeletal fixator. Both dogs remained comfortable and survived for 12 and 10 months respectively after diagnosis, despite the fact that neither primary tumour was resected.
authors.affiliation: The Royal Veterinary College, Department of Small Animal Medicine and Surgery, Hawkshead Lane, North Mymms.
authors.forename: J L
authors.initials: JL
authors.lastname: Tomlin
authors.forename: C
authors.initials: C
authors.lastname: Sturgeon
authors.forename: M J
authors.initials: MJ
authors.lastname: Pead
authors.forename: P
authors.initials: P
authors.lastname: Muir
mesh_terms: D019386:Alendronate / Q000627:therapeutic use*; D000818:Animals; D001859:Bone Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D016723:Bone Remodeling / Q000187:drug effects; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D008297:Male; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000662:veterinary; D012516:Osteosarcoma / Q000188:drug therapy / Q000662:veterinary*; D010166:Palliative Care; D011859:Radiography
chemical_list: D019386:Alendronate