title: Ontogeny of antipig xenoantibody and hyperacute rejection.
abstract: BACKGROUND
  Neonatal primates have been reported to receive pig hearts without hyperacute rejection (HAR). We examined the ontogeny of the anti-pig xenoantibody (XenoAb) and HAR in the neonatal and infant monkeys.
  
  
  METHODS
  Twenty-six serum samples from 15 monkeys ages 14-192 days were subjected to hemagglutination titration against pig erythrocytes. Ten pig hearts were heterotopically transplanted into the monkeys.
  
  
  RESULTS
  Six monkeys, ages 52-114 days, received pig hearts without HAR, and those ages 129-191 days hyperacutely rejected them. XenoAb titers were increased according to the age (Spearman's rank correlation value=0.909 (P<0.01)). XenoAb titers in 16 monkeys <4 months were significantly (P<0.01) lower than those in 10 monkeys >4 months.
  
  
  CONCLUSIONS
  Anti-pig XenoAb titers increased with the age of the monkeys. XenoAb levels in monkeys >4 months are high enough to reject pig hearts hyperacutely.
authors.affiliation: Department of Cardiothoracic Surgery, JR Tokyo General Hospital, Japan. m.kawauchi@jrtokyohosp.gr.jp
authors.forename: M
authors.initials: M
authors.lastname: Kawauchi
authors.forename: J
authors.initials: J
authors.lastname: Nakajima
authors.forename: M
authors.initials: M
authors.lastname: Endoh
authors.forename: T
authors.initials: T
authors.lastname: Oka
authors.forename: S
authors.initials: S
authors.lastname: Takamoto
mesh_terms: D000208:Acute Disease; D000375:Aging / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn; D000910:Antibodies, Heterophile / Q000097:blood*; D004912:Erythrocytes / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D006386:Hemagglutination Tests; D008251:Macaca; D013552:Swine; D013997:Time Factors; D016042:Transplantation, Heterotopic
chemical_list: D000910:Antibodies, Heterophile