On the role of animal models in risk assessment of neurotoxic pesticides.
A complication is given on the elements of risk assessment of hazardous neurotoxic pesticides, using data from human epidemiological studies, as well as animal experiments. Well-controlled laboratory studies of neurotoxicity have the potential to provide adequate exposure and effect data for accurate hazard identification. Using animal models of neurotoxicity as highly sensitive behavioral and neurophysiological methods as a function of doses, provide data for human low dose extrapolation by mathematical models. To reduce risk ("risk management") some examples are given how to handle properly neurotoxic pesticides with high risk.
Lehotzky
K
K
Fodor József Public Health Center, National Institute for Chemical Safety, Budapest, Hungary.
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D023421:Models, Animal; D009420:Nervous System / Q000187:drug effects*; D010575:Pesticides / Q000633:toxicity*; D018570:Risk Assessment
D002800:Cholinesterase Inhibitors; D010575:Pesticides