Pregnancy outcome in carriers of fragile X.
OBJECTIVE
To evaluate pregnancy outcome in women who are carriers of fragile X.


METHODS
Cross-sectional case-control study.


METHODS
Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.


METHODS
Sixty-three singleton pregnancies in carriers of fragile X who were referred for genetic counselling and prenatal diagnosis to Kuopio University Hospital.


METHODS
Logistic regression analysis was used to compare pregnancy outcome in women who are fragile X carrier with outcome of the general obstetric population.


RESULTS
Carriers of fragile X often experienced more bleeding in late pregnancy than did the reference group. Otherwise, the course and outcome of pregnancy were comparable in both groups.


CONCLUSIONS
Pregnancy outcome in women who are carriers of fragile X is favourable. There is no need to initiate special fetal monitoring because of the fragile X status of the woman.
Kallinen
J
J
Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.
Korhonen
K
K
Kortelainen
S
S
Heinonen
S
S
Ryynänen
M
M
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005600:Fragile X Syndrome / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D016015:Logistic Models; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D012307:Risk Factors; D014960:X Chromosome / Q000235:genetics*