title: Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia.
abstract: OBJECTIVE
  to evaluate the plasma IL-10 levels during elective operative repair of thoraco-abdominal and abdominal aortic aneurysm repair. To study whether IL-10 plasma levels are associated with the duration of cross-clamping (ischaemia) and clinical outcome.
  
  
  METHODS
  fifteen consecutive patients undergoing surgery for TAAA and 10 consecutive patients undergoing surgical repair of AAA were included.
  
  
  METHODS
  plasma concentrations of IL-10 were measured by ELISA technique. Clinical outcome of the TAAA patients was prospectively analysed.
  
  
  RESULTS
  during aortic clamping IL-10 was produced in both populations. The plasma IL-10 peak (934+/-172 pg/ml) of the TAAA group was seen at 4 h after declamping and remained detectable after 48 h. The plasma IL-10 peak (212+/-32 pg/ml) of the AAA group was seen 30 min after declamping and fell to undetectable levels by 24 h. These data show that the peak IL-10 plasma levels in TAAA repair are significantly (p<0.05) higher compared to the peak IL-10 plasma levels as seen during AAA repair. A positive correlation was seen between cross-clamping and peak plasma IL-10 and organ dysfunction.
  
  
  CONCLUSIONS
  IL-10 plasma concentrations appear higher, later and are longer detectable in patients undergoing TAAA. Correlations were seen with duration of cross-clamping and MSOD.
authors.affiliation: Department of Surgery, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: H S
authors.initials: HS
authors.lastname: Oldenburg
authors.forename: M
authors.initials: M
authors.lastname: Burress Welborn
authors.forename: J H
authors.initials: JH
authors.lastname: Pruitt
authors.forename: P G
authors.initials: PG
authors.lastname: Boelens
authors.forename: J M
authors.initials: JM
authors.lastname: Seeger
authors.forename: T D
authors.initials: TD
authors.lastname: Martin
authors.forename: R I
authors.initials: RI
authors.lastname: Wesdorp
authors.forename: J A
authors.initials: JA
authors.lastname: Rauwerda
authors.forename: P A
authors.initials: PA
authors.lastname: van Leeuwen
authors.forename: L L
authors.initials: LL
authors.lastname: Moldawer
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000601:surgery*; D003250:Constriction; D004797:Enzyme-Linked Immunosorbent Assay; D006402:Hematologic Diseases / Q000097:blood / Q000209:etiology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D007431:Intraoperative Complications / Q000097:blood* / Q000209:etiology* / Q000276:immunology; D007674:Kidney Diseases / Q000097:blood / Q000209:etiology; D008107:Liver Diseases / Q000097:blood / Q000209:etiology; D008171:Lung Diseases / Q000097:blood / Q000209:etiology; D016343:Monitoring, Intraoperative; D009102:Multiple Organ Failure / Q000097:blood / Q000209:etiology; D011446:Prospective Studies; D015427:Reperfusion Injury / Q000097:blood* / Q000209:etiology* / Q000276:immunology; D013997:Time Factors; D016896:Treatment Outcome; D014781:Viscera / Q000098:blood supply*
chemical_list: D016753:Interleukin-10