Translocation and action of polypeptide hormones within the nucleus. Relevance to lactogenic transduction.
The action of polypeptide hormones at the cell surface as mediated by transmembrane receptors is well recognised. However, a growing body of evidence also indicates that such hormones are also translocated and act directly within the cell nucleus. This chapter will overview what is known of the action of one such example, namely prolactin (PRL), from its classic action at the cell surface, to its novel function within the nucleus.
Clevenger
C V
CV
Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, USA.
Rycyzyn
M A
MA
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D001940:Breast / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology*; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000502:physiology; D011388:Prolactin / Q000502:physiology*; D015398:Signal Transduction
D011388:Prolactin