Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme.
The focus of this review will be on the regulation of the multigenic invasion programme by activator protein-1 (AP-1). Investigation of AP-1-regulated gene expression in transformed cells can be used to identify the genes in the multigenic invasion programme and to validate them as targets for diagnosis or therapy.
Ozanne
B W
BW
The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, G61 1BD, Glasgow, UK. b.ozanne@beatson.gla.ac.uk
McGarry
L
L
Spence
H J
HJ
Johnston
I
I
Winnie
J
J
Meagher
L
L
Stapleton
G
G
D018076:DNA, Complementary / Q000235:genetics; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D018808:Transcription Factor AP-1 / Q000235:genetics*; D015854:Up-Regulation
D018076:DNA, Complementary; D009363:Neoplasm Proteins; D018808:Transcription Factor AP-1