title: Physical model-based indirect measurements of blood pressure and flow using a centrifugal pump.
abstract: This article describes a technique offering indirect measurements of pump pressure differential and flow with certain accuracy independent of changes in blood viscosity. This technique is based on noninvasive measurements of the motor current and rotation speed using the physical model equations of the centrifugal pump system. Blood viscosity included in the coefficients of the dynamic equations is first estimated, and then substitution of the estimated viscosity into the steady equations of the model provides pump flow and pressure differential. In vitro tests using a Capiox pump showed a sufficient linear correlation between actual values and their estimates for pressure differential and pump flow. An in vivo test using a 45 kg sheep showed that the proposed algorithm needs robustness for the convergence of estimates of viscosity. An overall evaluation, however, of the developed algorithm/model showed indications of success in terms of efficient computation and modeling.
authors.affiliation: Department of Mechanical System Engineering, College of Computer Science and Systems Engineering, Kyushu Institute of Technology, Fukuoka, Japan. kita@mse.kyutech.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Matsushima
authors.forename: T
authors.initials: T
authors.lastname: Tokuyama
authors.forename: S
authors.initials: S
authors.lastname: Kono
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Komeda
authors.forename: M
authors.initials: M
authors.lastname: Yanai
authors.forename: T
authors.initials: T
authors.lastname: Kijima
authors.forename: C
authors.initials: C
authors.lastname: Nojiri
mesh_terms: D000465:Algorithms; D000818:Animals; D001794:Blood Pressure; D001809:Blood Viscosity; D006353:Heart-Assist Devices; D018056:Hemorheology; D016018:Least-Squares Analysis; D016014:Linear Models; D011312:Pressure; D012399:Rotation; D012756:Sheep