title: Hypoglycemic effect of extracts and fractions from Psacalium decompositum in healthy and alloxan-diabetic mice.
abstract: The hypoglycemic effect of the hexane, methanol and water extracts obtained from roots of Psacalium decompositum (Asteraceae) was investigated in fasting healthy mice. Only the water extract significantly reduced blood glucose in a dose-dependent manner in normal mice after intraperitoneal administration (P<0.05). This water extract was macerated with methanol obtaining a precipitate (WMP fraction), and it was studied in healthy and alloxan-diabetic mice. The WMP fraction showed significant hypoglycemic activity in healthy and mild diabetic mice, but the administration of this fraction to animals with severe diabetes did not cause any significant decrease in blood glucose levels. Two polysaccharide components isolated from WMP fraction showed hypoglycemic effect when tested in healthy mice.
authors.affiliation: Departmento de Ciencias de la Salud, Division Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Apdo. Postal 55-535, 09340 México D.F., Mexico.
authors.forename: F J
authors.initials: FJ
authors.lastname: Alarcon-Aguilar
authors.forename: M
authors.initials: M
authors.lastname: Jimenez-Estrada
authors.forename: R
authors.initials: R
authors.lastname: Reyes-Chilpa
authors.forename: R
authors.initials: R
authors.lastname: Roman-Ramos
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D006586:Hexanes; D007004:Hypoglycemic Agents / Q000032:analysis / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D000432:Methanol; D008800:Mexico; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011134:Polysaccharides / Q000032:analysis; D012997:Solvents; D014867:Water
chemical_list: D001786:Blood Glucose; D006586:Hexanes; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D011134:Polysaccharides; D012997:Solvents; D014867:Water; D000432:Methanol