Bilateral angle closure glaucoma and visual loss precipitated by antidepressant and antianxiety agents in a patient with depression.
A 71-year-old woman with depression had been treated with an antidepressant (maprotiline) and antianxiety agents (clotiazepam and alprazolam). She had previously complained of ocular pain and blurred vision. However, thorough ocular examination was not performed at those times. On examination, visual acuity was no light perception OD and hand motion OS. Intraocular pressures were 33 mm Hg OU. Moderately dilated pupils, atrophic irises, shallow anterior chambers and closed angles were seen in both eyes. Despite treatment, her visual acuity decreased to no light perception bilaterally. Psychiatrists and ophthalmologists should be aware that antidepressants and antianxiety agents can precipitate angle closure glaucoma in susceptible eyes.
Kadoi
C
C
Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
Hayasaka
S
S
Tsukamoto
E
E
Matsumoto
M
M
Hayasaka
Y
Y
Nagaki
Y
Y
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D000368:Aged; D000525:Alprazolam / Q000009:adverse effects; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D001381:Azepines / Q000009:adverse effects; D015784:Betaxolol / Q000008:administration & dosage / Q000627:therapeutic use; D001766:Blindness / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D003863:Depression / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D018463:Filtering Surgery / Q000379:methods; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000601:surgery; D053685:Laser Therapy; D008376:Maprotiline / Q000009:adverse effects; D008916:Miotics / Q000008:administration & dosage / Q000627:therapeutic use; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage / Q000627:therapeutic use; D014792:Visual Acuity / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D001381:Azepines; D008916:Miotics; D009883:Ophthalmic Solutions; D010862:Pilocarpine; D008376:Maprotiline; D015784:Betaxolol; D000525:Alprazolam; C084599:clotiazepam