title: Surgical management of endometriosis.
abstract: A systematic literature review of the last two decades was performed to evaluate the effect of pelvic denervations in addition to conservative surgery on dysmenorrhoea and deep dyspareunia associated with endometriosis. Chronic pelvic pain relief after hysterectomy or adhesiolysis was also assessed. In the five non-comparative studies on the effect of pre-sacral neurectomy, the frequency of dysmenorrhoea recurrence or persistence after treatment ranged from 4 to 40%. The pooled frequency of non-responders at the end of follow-up was 23% (95% confidence interval (CI), 19 to 27%). Only two of the three comparative, non-randomized trials demonstrated a significant treatment benefit of pre-sacral neurectomy, and the results of the two identified randomized controlled trials are discordant. Significant quantitative heterogeneity among studies prevented pooling of data on dysmenorrhoea. The common odds ratio of deep dyspareunia persistence was 0.69 (95% CI, 0.31 to 1.54). In the 10 non-comparative studies on the effect of uterosacral ligament resection, the frequency of dysmenorrhoea and deep dyspareunia persistence after treatment ranged, respectively, from 0 to 50% and from 6 to 42%. The pooled frequency of non-responders at the end of follow-up was 23% (95% CI, 20 to 27%) and 13% (95% CI, 8 to 18%), respectively. Routine performance of complementary denervating procedures cannot be recommended based on the quality of the evidence available. The results of the five studies on the effect of hysterectomy on chronic pelvic pain of presumed uterine origin consistently demonstrated that 83-97% of operated women reported pain relief or improvement 1 year after surgery. There is no consensus on the outcome of adhesiolysis in patients with chronic pain, and the role of pelvic adhesions in causing symptoms is under scrutiny.
authors.affiliation: First Department of Obstetrics and Gynaecology, University of Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Vercellini
authors.forename: O
authors.initials: O
authors.lastname: De Giorgi
authors.forename: A
authors.initials: A
authors.lastname: Pisacreta
authors.forename: A P
authors.initials: AP
authors.lastname: Pesole
authors.forename: S
authors.initials: S
authors.lastname: Vicentini
authors.forename: P G
authors.initials: PG
authors.lastname: Crosignani
mesh_terms: D000328:Adult; D003714:Denervation / Q000379:methods; D004715:Endometriosis / Q000150:complications / Q000601:surgery*; D005260:Female; D005836:Genitalia, Female / Q000294:innervation; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D008875:Middle Aged; D017699:Pelvic Pain / Q000209:etiology / Q000601:surgery*; D016032:Randomized Controlled Trials as Topic; D000267:Tissue Adhesions / Q000150:complications