The immune response against Helicobacter pylori--a direct linkage to the development of gastroduodenal disease.
Helicobacter pylori infects about half of the world's population. H. pylori elicits marked immune responses, but the infection is commonly life-long. Some infected individuals remain asymptomatic, while others develop significant gastroduodenal disease. We review the underlying host immune response to H. pylori which programs for persistence and evolution of gastroduodenal disease.
Ibraghimov
A
A
Department of Immunology, Astra Zeneca R+D, Boston, MA 02451, USA.
Pappo
J
J
D005753:Gastric Mucosa / Q000276:immunology / Q000382:microbiology; D005767:Gastrointestinal Diseases / Q000276:immunology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007111:Immunity, Cellular; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D007962:Leukocytes / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology