The spontaneous K-complex during stage 2 sleep: is it the 'forerunner' of delta waves?
The hypothesis that K-complexes (KCs) contribute to the process of synchronization leading to Slow-Wave Sleep (SWS) was evaluated by measuring their dynamic evolution across sleep cycles and before transitions to rapid eye movement (REM) or to SWS. KC density and inter-KC intervals respectively decreased and increased across the sleep cycles, revealing linear trends. Comparisons among transitions from stage 2 to SWS or to REM sleep showed a prevalence of KCs before the shift to SWS as compared to REM. Changes in KC density before the shift to SWS were fitted by a linear regression, at variance with the transition to REM sleep. Intra-night variations of KCs, paralleling the well-known decrease of slow waves across sleep cycles, and intracycle variations before shifting to SWS, both converge to indicate that KCs can be considered as the forerunner of delta waves.
De Gennaro
L
L
Dipartimento di Psicologia-Sezione di Neuroscienze, Università degli Studi 'La Sapienza', Via dei Marsi, 78; 00185, Roma, Italy. luigi.degennaro@uniroma1.it
Ferrara
M
M
Bertini
M
M
D000328:Adult; D000704:Analysis of Variance; D003700:Delta Rhythm; D004569:Electroencephalography; D004576:Electromyography; D004585:Electrooculography; D006801:Humans; D016014:Linear Models; D008297:Male; D017286:Polysomnography; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology