What is the function of receptor and membrane endocytosis at the postsynaptic neuron?
This paper explores the implications of certain new developments in cell biology upon neuroscience. Until recently it was thought that neurotransmitters and neuromodulators had only one function, which was to stimulate their specific receptors at the cell surface. From here on, all activity was supposed to be effected by postsynaptic cascades. The discovery that membrane components, particularly G-protein-linked receptors, are not static but are subject to a massive and complex process of continual endocytosis, processing in the endosome system and recycling back to the external membrane, raises the question of its functional significance. In addition, it has been found that many neuromodulators such as polypeptides have their main locus of action inside the postsynaptic neuron. This review covers the role of the endocytic mechanism on receptor desensitization and resensitization, synaptic reorganization and plasticity synaptic scaling and the possible repair of oxidative damage. The possible involvement of this system in Alzheimer's disease is discussed.
Smythies
J
J
Center for Brain and Cognition, Department of Psychology, University of California, San Diego, La Jolla 92093-0109, USA. smythies@psy.ucsd.edu
D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D004705:Endocytosis; D006801:Humans; D009474:Neurons / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D029701:Saccharomyces cerevisiae Proteins; D013569:Synapses
C109334:GPR1 protein, S cerevisiae; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D029701:Saccharomyces cerevisiae Proteins