title: Effects of vagus nerve stimulation on progressive myoclonus epilepsy of Unverricht-Lundborg type.
abstract: OBJECTIVE
  A 34-year-old woman with progressive myoclonus epilepsy of Unverricht-Lundborg type was considered for vagus nerve stimulation (VNS) therapy.
  
  
  METHODS
  After demonstration of intractability to multiple antiepileptic regimens and progressive deterioration in cerebellar function, the patient was implanted with a vagus nerve stimulator and followed for 1 year. Neurological status, seizure frequency, and parameter changes were analyzed.
  
  
  RESULTS
  VNS therapy resulted in reduction of seizures (more than 90%) and a significant improvement in cerebellar function demonstrated on neurological examination. The patient reported improved quality of life based in part on her ability to perform activities of daily living.
  
  
  CONCLUSIONS
  VNS therapy may be considered a treatment option for progressive myoclonus epilepsy. The effects of VNS on seizure control and cerebellar dysfunction may provide clues to the underlying mechanism(s) of action.
authors.affiliation: Department of Neurology, Henry Ford Health System, Detroit, Michigan, USA.
authors.forename: B
authors.initials: B
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Shatz
authors.forename: K
authors.initials: K
authors.lastname: Elisevich
authors.forename: I N
authors.initials: IN
authors.lastname: Bespalova
authors.forename: M
authors.initials: M
authors.lastname: Burmeister
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D002531:Cerebellum / Q000503:physiopathology; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D016896:Treatment Outcome; D020194:Unverricht-Lundborg Syndrome / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D000927:Anticonvulsants