title: Cutaneous pseudolymphoma, lymphomatoid contact dermatitis type, as an unusual cause of symmetrical upper eyelid nodules.
abstract: We describe a 74-year-old woman who rapidly developed bilateral voluminous nodules on the upper eyelids, following 4 months' treatment for chalazion. Histological and immunohistochemical findings were suggestive of cutaneous pseudolymphoma (CPL), and extensive screening for malignant lymphoma (ML) remained negative. Cutaneous pseudolymphomas are inflammatory diseases that can simulate ML either clinically, histopathologically, or both. They are a rare cause of nodules of the upper eyelids, usually characterized by a benign evolution, that can be secondary to ultraviolet sensitivity, adverse reactions to systemic medications and contact sensitization, among others. In our case, epicutaneous patch tests were strongly positive for a series of allergens contained in the ophthalmological preparations used; therefore, they were suggestive that the patient had CPL, lymphomatoid contact dermatitis type. In addition, the patient had been treated previously with several drugs, known to cause CPL and immune dysregulation. Complete regression of the lesions required treatment with systemic steroids and chlorambucil. No relapse occurred within a 5-year follow-up period.
authors.affiliation: Department of Dermatology, Professorial Unit, University Hospital Geneva, 24, rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. braun@cmu.unige.ch
authors.forename: R P
authors.initials: RP
authors.lastname: Braun
authors.forename: L E
authors.initials: LE
authors.lastname: French
authors.forename: R
authors.initials: R
authors.lastname: Feldmann
authors.forename: P
authors.initials: P
authors.lastname: Chavaz
authors.forename: J H
authors.initials: JH
authors.lastname: Saurat
mesh_terms: D000368:Aged; D017043:Chalazion / Q000188:drug therapy; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D005141:Eyelid Diseases / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis; D019310:Pseudolymphoma / Q000175:diagnosis* / Q000628:therapy