title: Factors influencing surgical complications of intra-axial brain tumours.
abstract: OBJECTIVE
  Extensive surgical resection remains nowadays the best treatment available for most intra-axial brain tumours. However, postoperative sequelae can outweigh the potential benefits of surgery. The goal of this study has been to review the results of this treatment in our Department in order to quantify morbidity and mortality and determine predictive risk factors for each patient.
  
  
  METHODS
  We report a retrospective study of 200 patients submitted to a craniotomy for intra-axial brain tumours including gliomas and metastases. Postoperative major complications are analysed and related to different variables. An exhaustive review of the literature concerning the main controversial points about primary and metastatic brain tumours surgery is done.
  
  
  RESULTS
  The overall major complication rate was 27.5%, with neurological complications being the most frequently encountered. We did not find a statistically significant relation between them and the grade of eloquence of the tumoural area. Infratentorial tumour location, previous radiotherapy and reoperations were factors strongly related to the incidence of regional complications. Age over 60 and severe concomitant disease were risk factors for systemic complications.
  
  
  CONCLUSIONS
  The results from published series concerning surgical complications after craniotomies for brain tumours are not comparable because of the lack of homogeneity between them. The knowledge of the complications rate in each particular neurosurgical department turns out essentially to provide the patient with tailored information about risks before surgery.
authors.affiliation: Department of Neurosurgery, Hospital Clínic, Universitat de Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Brell
authors.forename: J
authors.initials: J
authors.lastname: Ibáñez
authors.forename: L
authors.initials: L
authors.lastname: Caral
authors.forename: E
authors.initials: E
authors.lastname: Ferrer
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D003399:Craniotomy / Q000009:adverse effects*; D005260:Female; D005910:Glioma / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011878:Radiotherapy; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome