title: Abnormal information processing in dementia of Alzheimer type. A study using the event-related potential's field.
abstract: Electrical field changes of event-related potentials (ERPs) were investigated in 26 patients with dementia of Alzheimer's type (DAT) and 12 age-matched normal subjects. The patients were assessed with the Clinical Dementia Rating and Mini-Mental State. Each patient selected had only mild to moderate mental disability. Auditory oddball stimulation was presented at 1.5 s intervals and 1,000 Hz for the nontarget and 2,000 Hz for the target tones, both at 85 dB. The target tones were 20% of all the tones. The reference-independent data (latency, global field power: GFP, dissimilarity index: DISS and location of centroids) were obtained and analyzed for each ERP component. The momentary electric strength or 'hilliness' of the ERPs landscape was indicated by GFP. The patients showed prolonged latencies and decreased P300 GFP amplitudes and of N100 GFP. These findings suggest that the abnormal electrical field of ERP may reflect abnormal information processing following the attentional process for target stimuli in DAT patients.
authors.affiliation: Department of Neurology, Dokkyo University School of Medicine, Japan. hirata@dokkyomed.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: A
authors.initials: A
authors.lastname: Hozumi
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Kubo
authors.forename: X H
authors.initials: XH
authors.lastname: Zeng
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Asahi
authors.forename: T
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000368:Aged; D000544:Alzheimer Disease; D001288:Attention / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis*; D005071:Evoked Potentials; D006801:Humans; D009483:Neuropsychological Tests; D012720:Severity of Illness Index