title: Different expression of some molecular markers in sporadic cancer of the left and right colon.
abstract: The expression of cytoplasmic c-erbB2, epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and dipeptidylpeptidase IV (DPP IV) was significantly higher in sporadic cancer of the right than of the left colon. In addition, cytoplasmic c-erbB2 displayed the same difference in the adjacent (less than 2 cm) and distant (more than 5 cm from the tumour margin) mucosa. The findings cannot be related to Dukes staging. It is suggested that different ontogenic development of the right (from the midgut) and the left (from the hindgut) colon may be a possible explanation. Therefore, data on the expression of different molecular markers in colorectal cancer and surrounding mucosa should always be supplemented by data on tumour location.
authors.affiliation: Central Military Hospital and Postgraduate Institute of Medicine, Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Fric
authors.forename: V
authors.initials: V
authors.lastname: Sovová
authors.forename: E
authors.initials: E
authors.lastname: Sloncová
authors.forename: Z
authors.initials: Z
authors.lastname: Lojda
authors.forename: A
authors.initials: A
authors.lastname: Jirásek
authors.forename: J
authors.initials: J
authors.lastname: Cermák
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018819:Dipeptidyl Peptidase 4; D066246:ErbB Receptors; D018809:Proliferating Cell Nuclear Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases