title: Transverse myelitis associated with restless legs syndrome and periodic movements of sleep responsive to an oral dopaminergic agent but not to intrathecal baclofen.
abstract: Periodic limb movement disorder (PLMD) and restless legs syndrome (RLS) are related sleep disorders that occur with increased frequency in spinal cord disease. Effective treatment may be obtained with dopaminergic or opioid drugs, while anticonvulsants, benzodiazepines, and possibly baclofen may be helpful. This report describes a patient who developed RLS and PLMD after acute transverse myelitis associated with infectious mononucleosis, and failed to respond to intrathecal baclofen. All symptoms of RLS/PLMD resolved after treatment with pergolide.
authors.affiliation: The University of Arizona College of Medicine, Tucson, AZ, USA. lkbrown@alum.mit.edu
authors.forename: L K
authors.initials: LK
authors.lastname: Brown
authors.forename: J E
authors.initials: JE
authors.lastname: Heffner
authors.forename: E A
authors.initials: EA
authors.lastname: Obbens
mesh_terms: D000208:Acute Disease; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001418:Baclofen / Q000008:administration & dosage / Q000627:therapeutic use*; D004576:Electromyography; D004585:Electrooculography; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000627:therapeutic use*; D009188:Myelitis, Transverse / Q000150:complications* / Q000188:drug therapy*; D020189:Nocturnal Myoclonus Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D010479:Pergolide / Q000008:administration & dosage / Q000627:therapeutic use*; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D012895:Sleep, REM / Q000502:physiology; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D009125:Muscle Relaxants, Central; D010479:Pergolide; D001418:Baclofen