The meningeal permeability of R- and S-bupivacaine are not different: evidence that pharmacodynamic differences between the enantiomers are not the result of differences in bioavailability.
Bernards
C M
CM
Department of Anesthesiology, University of Washington, Seattle, Washington, USA. chrisb@u.washington.edu
Ulma
G A
GA
Kopacz
D J
DJ
D000779:Anesthetics, Local / Q000493:pharmacokinetics*; D000818:Animals; D001682:Biological Availability; D002045:Bupivacaine / Q000493:pharmacokinetics* / Q000494:pharmacology; D008254:Macaca nemestrina; D008578:Meninges / Q000378:metabolism*; D010539:Permeability; D013237:Stereoisomerism
D000779:Anesthetics, Local; D002045:Bupivacaine