title: Biotransformation of a C-glycosylflavone, abrusin 2''-O-beta-D-apioside, by human intestinal bacteria.
abstract: After anaerobic incubation of abrusin 2''-O-beta-D-apioside (1) with a human fecal suspension, five metabolites were isolated and identified as abrusin (2), 1-(2',6'-dihydroxy-3',4'-dimethoxyphenyl)-3-(4''-hydroxyphenyl)propan-1- one (5), 5,6-dimethoxybenzene-1,3-diol (6), 3-(4'-hydroxyphenyl)propionic acid (7) and 3-phenylpropionic acid (8). However, methyl ether derivatives of abrusin (4'-O-methylabrusin and 4'-O-, 5-O-dimethylabrusin) resisted degradation under the same conditions.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: M R
authors.initials: MR
authors.lastname: Meselhy
authors.forename: L Q
authors.initials: LQ
authors.lastname: Wang
authors.forename: C M
authors.initials: CM
authors.lastname: Ma
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Hattori
mesh_terms: D001711:Biotransformation; D005419:Flavonoids / Q000493:pharmacokinetics*; D006027:Glycosides / Q000493:pharmacokinetics*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D013058:Mass Spectrometry / Q000379:methods
chemical_list: D005419:Flavonoids; D006027:Glycosides; C417233:abrusin 2''-O-apioside