Metabolism of O6-propyl and N6-propyl-carbovir in CEM cells.
The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'-triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3-nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.
Parker
W B
WB
Southern Research Institute, Birmingham, AL 35205, USA.
Shaddix
S C
SC
Rose
L M
LM
Pham
P T
PT
Hua
M
M
Vince
R
R
D000478:Alkylation; D019380:Anti-HIV Agents / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000378:metabolism*; D002460:Cell Line / Q000378:metabolism*; D015224:Dideoxynucleosides / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000378:metabolism*; D015497:HIV-1 / Q000187:drug effects / Q000378:metabolism; D009173:Mycophenolic Acid / Q000494:pharmacology; D015649:Pentostatin / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; C057503:carbovir; D015649:Pentostatin; D009173:Mycophenolic Acid