title: Changing trends in genital herpes simplex virus infection in Bergen, Norway.
abstract: OBJECTIVE
  To document the proportion of each herpes simplex virus (HSV) type in genital HSV infection and changes over time during a 10 year period.
  
  
  METHODS
  Retrospective comparative study in sexually transmitted disease (STD) patients with genital HSV infection at the outpatient clinic for STD, Haukeland Hospital, Bergen, Norway.
  
  
  RESULTS
  HSV-2 was the major cause during the 80's, whereas HSV-1 constitutes a greater part of the cases during the 90's, especially in female patients and in the younger age groups with primary or initial disease, where HSV-1 is the causative viral type in up to 70-90% of the cases.
  
  
  CONCLUSIONS
  The documented change from HSV-2 towards HSV-1 in cases of genital HSV infection may have implications as to prognosis, future usefulness of vaccines, present and future usefulness of new type-specific serological tests.
authors.affiliation: Department of Dermatovenerology, University of Bergen, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Nilsen
authors.forename: H
authors.initials: H
authors.lastname: Myrmel
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D006558:Herpes Genitalis / Q000453:epidemiology* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D018258:Herpesvirus 2, Human / Q000472:pathogenicity*; D006801:Humans; D015994:Incidence; D008297:Male; D009664:Norway / Q000453:epidemiology