title: [Splenic vascular occlusion in the course of pancreatic cancer].
abstract: BACKGROUND
  Pancreatic cancer is responsible for 6,000 deaths per year in France. During the course of the disease, venous thrombosis is common. Conversely, arterial thrombosis is rarely described.
  
  
  METHODS
  We report the case of a 59-year-old patient with pancreatic adenocarcinoma. Treatment by gemcitabine allowed rapid and persistent improvement of the body weight and a prolonged survival (18 months). Sudden complication, i.e. splenic arterial thrombosis, reversed the favorable outcome.
  
  
  CONCLUSIONS
  Splenic venous thrombosis is a frequent complication occurring in the course of pancreatic cancer. It is easily diagnosed using abdominal computerized tomography. Arterial thrombosis is rarely observed. It might be due to either sporadic, unexpected, occurrence of cases related to the evolution of underlying pathological mechanisms, or to omitted treatment of vascular complications, as until the introduction of new anticancer drugs this disease was considered to be of very poor prognosis.
authors.affiliation: Clinique de médecine interne et maladies infectieuses, hôpital du Haut-Lévêque, Pessac, France.
authors.forename: P
authors.initials: P
authors.lastname: Mercié
authors.forename: I
authors.initials: I
authors.lastname: Faure
authors.forename: J F
authors.initials: JF
authors.lastname: Viallard
authors.forename: H
authors.initials: H
authors.lastname: Demeaux
authors.forename: M S
authors.initials: MS
authors.lastname: Dilhuydy
authors.forename: B
authors.initials: B
authors.lastname: Leng
authors.forename: J L
authors.initials: JL
authors.lastname: Pellegrin
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000188:drug therapy; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007238:Infarction / Q000000981:diagnostic imaging / Q000209:etiology; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000188:drug therapy; D013154:Spleen / Q000098:blood supply* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine