title: Do medical devices have enhanced placebo effects?
abstract: Although the placebo in a clinical trial is often considered simply a baseline against which to evaluate the efficacy of a clinical intervention, there is evidence that the magnitude of placebo effect may be a critical factor in determining the results of a trial. This article examines the question of whether devices have enhanced placebo effects and, if so, what the implications may be. While the evidence of an enhanced placebo effect remains rudimentary, it is provocative and therefore worthy of further study. Suggestions are made, therefore, for how such an effect can be investigated without violating the principles of informed consent.
authors.affiliation: Center for Alternative Medicine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. tkaptchu@caregroup.harvard.edu
authors.forename: T J
authors.initials: TJ
authors.lastname: Kaptchuk
authors.forename: P
authors.initials: P
authors.lastname: Goldman
authors.forename: D A
authors.initials: DA
authors.lastname: Stone
authors.forename: W B
authors.initials: WB
authors.lastname: Stason
mesh_terms: D002986:Clinical Trials as Topic; D004864:Equipment and Supplies; D006801:Humans; D015990:Placebo Effect; D012107:Research Design