Structure-function studies on beta 2-glycoprotein I.
Human beta 2-glycoprotein I is a heavily glycosylated plasma protein which has been implicated in the binding of antiphospholipid antibodies to negatively charged phospholipids; a process considered as an important risk factor for the development of thrombosis. We have solved the crystal structure of beta 2-glycoprotein I. In this review we will discuss what the three-dimensional structure teaches us about the role of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome.
de Groot G
P G
PG
Haemostasis and Thrombosis Laboratory, University Medical Center, University Utrecht, Utrecht, The Netherlands.
Bouma
B
B
Lutters
B C
BC
Simmelink
M J
MJ
Derksen
R H
RH
Gros
P
P
D006023:Glycoproteins / Q000097:blood / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010743:Phospholipids / Q000378:metabolism; D011485:Protein Binding; D013329:Structure-Activity Relationship; D053482:beta 2-Glycoprotein I
D006023:Glycoproteins; D010743:Phospholipids; D053482:beta 2-Glycoprotein I