Development of an efficient intermediate, alpha-[2-(trimethylsilyl)ethoxy]-2-N- [2-(trimethylsilyl)ethoxycarbonyl]folic acid, for the synthesis of folate (gamma)-conjugates, and its application to the synthesis of folate-nucleoside conjugates.
Nomura
M
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
Shuto
S
S
Matsuda
A
A
D005492:Folic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008956:Models, Chemical; D009705:Nucleosides / Q000138:chemical synthesis*; D020319:Oligodeoxyribonucleotides, Antisense / Q000138:chemical synthesis
D009705:Nucleosides; D020319:Oligodeoxyribonucleotides, Antisense; D005492:Folic Acid