title: Dysphagia with multiple autoimmune disease.
abstract: Myasthenia gravis (MG) and polymyositis (PM) are organ-specific autoimmune diseases. Occasional reports describe patients with clinical and pathologic features of both. Achalasia is idiopathic in nature, but autoimmune and inflammatory mechanisms have been proposed for this disorder as well. We describe a patient with dysphagia who was diagnosed at different points in time with all these three rare conditions. Despite at least putatively having immune mechanisms in common, an association between the three has not been previously described.
authors.affiliation: Department of Medicine H, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Kornizky
authors.forename: I
authors.initials: I
authors.lastname: Heller
authors.forename: A
authors.initials: A
authors.lastname: Isakov
authors.forename: I
authors.initials: I
authors.lastname: Shapira
authors.forename: M
authors.initials: M
authors.lastname: Topilsky
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D003680:Deglutition Disorders / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D004931:Esophageal Achalasia / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D009132:Muscles / Q000473:pathology; D009157:Myasthenia Gravis / Q000150:complications* / Q000175:diagnosis; D017285:Polymyositis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D011241:Prednisone; D008727:Methotrexate