Effects of temperature on the elimination of benzocaine and acetylated benzocaine residues from the edible fillet of rainbow trout (Oncorhynchus mykiss).
The effect of temperature (7 degrees C and 16 degrees C) on the extent of accumulation and the elimination of benzocaine (BNZ) and its metabolite, acetylated benzocaine (AcBNZ), in the fillet tissue of rainbow trout was investigated. Residues were measured after bath exposure to an anesthetizing concentration of benzocaine (30 mg/l for 5 min) followed by a maintenance concentration (15 mg/l for 30 min). Immediately after exposure, the BNZ concentration in fillet tissue was approximately 27 micrograms/g at both temperatures; AcBNZ was 0.3 microgram/g at 7 degrees C and 0.6 microgram/g at 16 degrees C. The rates for elimination (alpha and beta) of BNZ and AcBNZ were not significantly different between the two temperatures. Terminal half-lives of elimination for BNZ were 1.62 h at 7 degrees C and 1.63 h at 16 degrees C; half-lives for AcBNZ were 2.36 h at 7 degrees C and 2.77 h at 16 degrees C.
Stehly
G R
GR
US Geological Survey, Biological Resources Division, Upper Midwest Environmental Sciences Center, La Crosse, Wisconsin 54603, USA. guy_stehly@usgs.gov
Meinertz
J R
JR
Gingerich
W H
WH
D000779:Anesthetics, Local / Q000378:metabolism; D000818:Animals; D001566:Benzocaine / Q000378:metabolism*; D004350:Drug Residues / Q000378:metabolism*; D017686:Oncorhynchus mykiss / Q000378:metabolism*; D013696:Temperature
D000779:Anesthetics, Local; D001566:Benzocaine