[Blood serum eotaxin and eosinophil cationic protein in asthmatic patients].
Eotaxin belongs to CC class of chemokines and is a potent eosinophil chamoattractant. Activated eosinophils are able to release many cytotoxic proteins, including eosinophil cationic protein (ECP), which has central role in allergic inflammation. The aim of this study was to assess eotaxin and ECP levels in plasma of atopic asthma patients in stable period of the disease. 19 patients with asthma and 10 healthy controls took part in this study. ELISA test was used to measure eotaxin (kits from R&D, pg/ml) and ECP (kits from Pharmacia, mg/l) levels. Plasma eotaxin level (mean +/- SD) was 176.52 +/- 50.3 (range 89-288) in asthma patients and 101.42 +/- 49.4 (range 35-206) in control group (p < 0.001). Plasma ECP concentration was 16.7 +/- 6.4 (6.3-28) and 16.8 +/- 17.1 (3.1-61.6), respectively (n.s). There was correlation between plasma eotaxin and ECP levels (Pearsons correlation co. r = +0.5, p < 0.05) and between eotaxin and FEV1 (Pearsons correlation co r = -0.4, p < 0.05) in asthma patients. We suggest that measurement of eotaxin and ECP levels as well may be useful indicator of disease.
Jahnz-Rózyk
K
K
Kliniki Chorób Wewnetrznych, Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Centralnego Szpitala Klinicznego WAM w Warszawie.
Płusa
T
T
Mierzejewska
J
J
D000328:Adult; D001249:Asthma / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D002412:Cations / Q000097:blood; D002631:Chemotactic Factors, Eosinophil / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male
D001798:Blood Proteins; D002412:Cations; D002631:Chemotactic Factors, Eosinophil