Maxillary giant cell granuloma, pheochromocytoma, and hyperparathyroidism without medullary thyroid carcinoma.
We examined a young man who had a benign giant cell granuloma of the maxilla, which we subsequently diagnosed as a brown tumor associated with hyperparathyroidism. During surgery for the granuloma, the patient developed severe hypertension and was discovered to have an extra-adrenal pheochromocytoma. Oncogene and calcitonin testing for medullary carcinoma of the thyroid was negative. Therefore, despite the presence of both pheochromocytoma and hyperparathyroidism, we concluded that this patient did not have multiple endocrine neoplasia type 2a.
McManus
R
R
Department of Medicine, University of Western Ontario, London, Canada. rmcmanus@lhsc.on.ca
BoAbbas
Y
Y
Lampe
H
H
Holliday
R
R
Shum
D
D
D000328:Adult; D003937:Diagnosis, Differential; D006101:Granuloma, Giant Cell / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008441:Maxillary Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018813:Multiple Endocrine Neoplasia Type 2a / Q000175:diagnosis; D010673:Pheochromocytoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery