title: The development of optical nanosensors for biological measurements.
abstract: This article discusses and documents the basic concepts of, and developments in, the field of optical nanosensors and nanobiosensors. It describes the progression of this field of research from its birth up to the present, with emphasis on the techniques of sensor construction and their application to biological systems. After a brief overview of the techniques for fabricating nanometer-sized optical fibers, we describe the various types of transducer and bioreceptor molecule presently used for nanosensor and nanobiosensor fabrication.
authors.affiliation: Advanced Monitoring Development Group, Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, TN 37831-6101, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Cullum
authors.forename: T
authors.initials: T
authors.lastname: Vo-Dinh
mesh_terms: D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods / Q000639:trends*; D006801:Humans; D008855:Microscopy, Electron, Scanning / Q000295:instrumentation / Q000379:methods / Q000639:trends; D055095:Optics and Photonics / Q000295:instrumentation*; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods / Q000639:trends