Androgenic sensitivity of polyamine-oxidizing enzyme activities in female rat tissues.
Effects of testosterone (10 micrograms/100g body weight) on polyamine-oxidizing enzyme activities in female rat uterus, liver and kidney were demonstrated. Testosterone-treated rats exhibited 2.07 fold (p < 0.002) higher uterine polyamine oxidase (PAO) activity and 1.93 fold (p < 0.02) higher diamine oxidase (DAO) activity, as compared to the controls. In the liver, testosterone caused an elevation in PAO (1.39 fold, p < 0.05), but not in DAO activity, whereas in kidney the hormone stimulated DAO (1.30 fold, p < 0.05), but not PAO activity. The effects observed suggest a possible role for testosterone in the modulation of polyamine levels in the female organs studied and especially in uterus.
Pavlov
V
V
Department of Human and Animal Physiology, Faculty of Biology, University of Sofia St. Kliment Ohridski, Bulgaria.
Dimitrov
O
O
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects / Q000201:enzymology; D000097667:Polyamine Oxidase
D006631:Amine Oxidase (Copper-Containing); D000587:Oxidoreductases Acting on CH-NH Group Donors; D013739:Testosterone; D000097667:Polyamine Oxidase