Primary biliary cirrhosis associated with idiopathic retroperitoneal fibrosis.
Idiopathic retroperitoneal fibrosis (IRF) and primary biliary cirrhosis (PBC) are distinct clinical disorders which rarely occur in the same patient. We report a 79-year-old man with the coexistence of both conditions. The patient had antibodies to both centromere and mitochondria, as indicated by indirect immunofluorescence. Diagnoses of IRF and PBC were confirmed histologically. Although the association between IRF and PBC is obscure, IRF may be involved in many autoimmune diseases associated with PBC.
Shikuwa-
S
S
Department of Internal Medicine, Nagasaki Chuo National Hospital, Omura, Japan.
Omagari
K
K
Mizuta
Y
Y
Murase
K
K
Osabe
M
M
Yoshimura
M
M
Ohfukuji
M
M
Takehara
Y
Y
Isomoto
H
H
Ito
M
M
Shimokawa
I
I
Kohno
S
S
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D002503:Centromere / Q000276:immunology; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008928:Mitochondria / Q000276:immunology; D012185:Retroperitoneal Fibrosis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology
D019268:Antibodies, Antineutrophil Cytoplasmic; D000974:Antibodies, Antinuclear; D001323:Autoantibodies