title: Toll-like receptors in the induction of the innate immune response.
abstract: The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.
authors.affiliation: Department of Immunology, University of Washington, Seattle 98195, USA.
authors.forename: A
authors.initials: A
authors.lastname: Aderem
authors.forename: R J
authors.initials: RJ
authors.lastname: Ulevitch
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology; D029721:Drosophila Proteins; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007113:Immunity, Innate / Q000502:physiology; D008562:Membrane Glycoproteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D015398:Signal Transduction; D051193:Toll-Like Receptors
chemical_list: D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors