Soluble polymer-supported organic synthesis.
Soluble polymers have been used as supports for reagent/catalyst immobilization and synthesis. Two polymers are commonly used in this context, linear polystyrene and poly(ethylene glycol). The complementary solubility properties of these polymers allow access to a wide range of chemistries. Parallel and combinatorial libraries of small molecules have been prepared using these polymers, and reagents/catalysts that are easily recovered and recycled have been immobilized on them. To develop soluble polymers with novel properties, bifunctional polymerization initiators have been used in a parallel combinatorial methodology to prepare block copolymers that exhibit unique solubility profiles.
Toy
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Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Janda
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D007202:Indicators and Reagents; D009930:Organic Chemicals / Q000138:chemical synthesis*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility
D007202:Indicators and Reagents; D009930:Organic Chemicals; D011108:Polymers