Atom transfer reactions of TMM diyls directed toward the synthesis of rudmollin.
Intramolecular hydrogen atom transfer to a trimethylenemethane (TMM) diradical has been explored as a route to the antileukemial agent, rudmollin (1).
Carroll
G L
GL
Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
Allan
A K
AK
Schwaebe
M K
MK
Little
R D
RD
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005609:Free Radicals; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation
D000970:Antineoplastic Agents; D005609:Free Radicals; D006575:Heterocyclic Compounds, 3-Ring; D007202:Indicators and Reagents; C413207:rudmollin