title: Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1.
abstract: A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 microM.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, South Korea.
authors.forename: H W
authors.initials: HW
authors.lastname: Jeong
authors.forename: M R
authors.initials: MR
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Son
authors.forename: M Y
authors.initials: MY
authors.lastname: Han
authors.forename: J H
authors.initials: JH
authors.lastname: Ha
authors.forename: M
authors.initials: M
authors.lastname: Garnier
authors.forename: L
authors.initials: L
authors.lastname: Meijer
authors.forename: B M
authors.initials: BM
authors.lastname: Kwon
mesh_terms: D000818:Animals; D002934:Cinnamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019938:Cyclin D1 / Q000037:antagonists & inhibitors*; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D015394:Molecular Structure; D011518:Proto-Oncogene Proteins
chemical_list: D002934:Cinnamates; D004791:Enzyme Inhibitors; D011518:Proto-Oncogene Proteins; C117045:p-hydroxycinnamaldehyde; D019938:Cyclin D1; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases