HIV-1 dynamics revisited: biphasic decay by cytotoxic T lymphocyte killing?
The biphasic decay of blood viraemia in patients being treated for human immunodeficiency virus type 1 (HIV-1) infection has been explained as the decay of two distinct populations of cells: the rapid death of productively infected cells followed by the much slower elimination of a second population the identity of which remains unknown. Here we advance an alternative explanation based on the immune response against a single population of infected cells. We show that the biphasic decay can be explained simply, without invoking multiple compartments: viral load falls quickly while cytotoxic T lymphocytes (CTL) are still abundant, and more slowly as CTL disappear. We propose a method to test this idea, and develop a framework that is readily applicable to treatment of other infections.
Arnaout
R A
RA
Theoretical Biology Program, Institute for Advanced Study, Princeton, NJ 08540, USA. ramy_arnaout@student.hms.harvard.edu
Nowak
M A
MA
Wodarz
D
D
D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008962:Models, Theoretical; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D019562:Viral Load