title: Correlation of peri-implant health and aspartate aminotransferase levels: a cross-sectional clinical study.
abstract: At present, there are no diagnostic tools that permit early detection of peri-implantitis. The purpose of this cross-sectional study was to evaluate the correlation of aspartate aminotransferase (AST) levels with traditional periodontal clinical parameters around dental implants, since AST has been associated with destruction of cardiac, hepatic, and periodontal tissues. Twenty healthy volunteers with 59 implants were recruited from the Harvard School of Dental Medicine clinics. Clinical parameters evaluated included: AST level, probing depth (mm), Gingival Index (0, 1, 2, or 3), and bleeding on probing (0 or 1). Utilizing the site or implant as the unit of measure, the authors found a statistically significant association of increased AST activity with positive bleeding on probing, increased probing depth, and increased Gingival Index. No statistical correlations were found between clinical indices and increased AST levels when the results were examined on an individual patient basis. This cross-sectional study was able to demonstrate a statistical correlation between diseased clinical periodontal parameters and elevated AST levels.
authors.affiliation: Department of Periodontology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA. joseph_fiorellini@hms.harvard.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Fiorellini
authors.forename: M L
authors.initials: ML
authors.lastname: Nevins
authors.forename: J
authors.initials: J
authors.lastname: Sekler
authors.forename: A
authors.initials: A
authors.lastname: Chung
authors.forename: R J
authors.initials: RJ
authors.lastname: Oringer
mesh_terms: D001219:Aspartate Aminotransferases / Q000032:analysis; D004796:Clinical Enzyme Tests; D003430:Cross-Sectional Studies; D015921:Dental Implants / Q000009:adverse effects*; D005260:Female; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D006801:Humans; D008297:Male; D010512:Periodontal Index; D010518:Periodontitis / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology*; D018709:Statistics, Nonparametric
chemical_list: D015921:Dental Implants; D001219:Aspartate Aminotransferases