Early vasculopathy following radiation in a child with medulloblastoma.
A child with severe radiation vasculopathy 15 months following radiation therapy for medulloblastoma is reported. The patient underwent surgical resection of a posterior fossa medulloblastoma, followed by chemotherapy and radiation therapy. He was treated with 55 Gy to the craniospinal axis. Fifteen months later, the patient presented with a subacute neurologic deterioration from multiple ischemic events that resulted from severe radiation vascular injury. We compare and contrast this case to similar case reports in the literature.
Maher
C O
CO
Department of Neurosurgery, Mayo Clinic, Rochester, Minn., USA. maher.cormac@mayo.edu
Raffel
C
C
D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000209:etiology; D002528:Cerebellar Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000209:etiology*; D002560:Cerebrovascular Circulation / Q000528:radiation effects*; D002648:Child; D003388:Cranial Fossa, Posterior; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000188:drug therapy / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000000981:diagnostic imaging* / Q000209:etiology; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects*