Transforming growth factor beta1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans.
Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor beta1 (TGF-beta1). None of the prechallenge biopsies exhibited TGF-beta. Seven of 12 volunteers with oocyst shedding expressed TGF-beta versus 2 of 13 volunteers without detected oocysts. The association of TGF-beta expression with oocyst excretion and the timing of symptoms suggests that TGF-beta mediates intestinal healing.
Robinson
P
P
Department of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA.
Okhuysen
P C
PC
Chappell
C L
CL
Lewis
D E
DE
Shahab
I
I
Lahoti
S
S
White
A C
AC
D000818:Animals; D003457:Cryptosporidiosis / Q000276:immunology* / Q000378:metabolism; D016785:Cryptosporidium parvum; D006801:Humans; D007583:Jejunum / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D016212:Transforming Growth Factor beta / Q000235:genetics*
D012333:RNA, Messenger; D016212:Transforming Growth Factor beta