title: Synthesis and pharmacological characteristics of novel (Z)-3-arylidene-indolin-2(1H)-ones: preliminary results.
abstract: New amide derivatives of 1-(m-chlorophenyl)piperazine, the 5-HT2A antagonists 3-6, with moderate in vitro and in vivo activity were obtained by enlargement of the indolin-2(1H)-one core with 3-arylidene substituents.
authors.affiliation: Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
authors.forename: M J
authors.initials: MJ
authors.lastname: Mokrosz
authors.forename: S
authors.initials: S
authors.lastname: Charakchieva-Minol
authors.forename: A
authors.initials: A
authors.lastname: Kozioł
authors.forename: A
authors.initials: A
authors.lastname: Kłodzińska
authors.forename: E
authors.initials: E
authors.lastname: Chojnacka-Wójcik
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051379:Mice; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects*; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D007211:Indoles; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D007650:Ketanserin