Adsorption of omeprazole on latex particles and characterization of the complex.
Omeprazole is an antisecretory drug used against gastric ulcers. It quickly decomposes in an acid medium, however, therefore making it a matter of great interest to protect it in these conditions and determine the ideal adsorption conditions for this drug on latex particles for formulation designs--oral suspensions--containing polymers with the aim of delivering different drugs in a sustained and controlled action. Time, pH, and concentration of the active ingredient for which maximum adsorption occurs, were determined. The findings suggest that adsorption is evidently greatest at an acid pH 4-5, that the adsorption of Omeprazole rises concomitantly with the increase in latex particles, and the time is the least influential factor.
Ruiz
M A
MA
Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Spain.
Reyes
I
I
Parera
A
A
Gallardo
V
V
D000327:Adsorption; D000897:Anti-Ulcer Agents / Q000737:chemistry*; D007840:Latex / Q000737:chemistry; D009853:Omeprazole / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*
D000897:Anti-Ulcer Agents; D007840:Latex; D011134:Polysaccharides; C059120:Aquateric; D009853:Omeprazole