title: Transforming growth factor beta1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans.
abstract: Biopsies from volunteers challenged with Cryptosporidium parvum were examined for transforming growth factor beta1 (TGF-beta1). None of the prechallenge biopsies exhibited TGF-beta. Seven of 12 volunteers with oocyst shedding expressed TGF-beta versus 2 of 13 volunteers without detected oocysts. The association of TGF-beta expression with oocyst excretion and the timing of symptoms suggests that TGF-beta mediates intestinal healing.
authors.affiliation: Department of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: P
authors.initials: P
authors.lastname: Robinson
authors.forename: P C
authors.initials: PC
authors.lastname: Okhuysen
authors.forename: C L
authors.initials: CL
authors.lastname: Chappell
authors.forename: D E
authors.initials: DE
authors.lastname: Lewis
authors.forename: I
authors.initials: I
authors.lastname: Shahab
authors.forename: S
authors.initials: S
authors.lastname: Lahoti
authors.forename: A C
authors.initials: AC
authors.lastname: White
mesh_terms: D000818:Animals; D003457:Cryptosporidiosis / Q000276:immunology* / Q000378:metabolism; D016785:Cryptosporidium parvum; D006801:Humans; D007583:Jejunum / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D016212:Transforming Growth Factor beta / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D016212:Transforming Growth Factor beta