title: [Manifestation of primary biliary cirrhosis and Basedow's disease caused by exposure to carbon monoxide in a patient with HTLV-1 associated myelopathy].
abstract: A 55-year-old woman with HTLV-1 associated myelopathy (HAM) was discovered in a rentan kotatsu (Japanese foot warmer with a frame and a coverlet by burning briquet) with conscious disorder and admitted to an emergency hospital. Her conscious disturbance waned the 3rd day after admission with gradual improvement of communication and food intake. However, on the 18th day after admission, her orientation was poor again and she was unable to take food for herself and keep sitting. She was diagnosed as suffering from an interval form of acute carbon monoxide (CMO) poisoning and transferred to our hospital for the purpose of hyperbaric oxygen therapy on the 20th day after exposure to CMO. In the course of treatment she recovered but showed jaundice, pruritus, liver dysfunction and elevation of antimitochondrial antibody. She received liver biopsy and was found to have primary biliary cirrhosis (PBC). On the 150th day, she manifested perspiration and hypertension. The clinical and immunological feature revealed her Basedow's disease. The relationship between HAM and PBC due to the autoimmune process has been predicted by investigators. The implication of autoimmune disease and HLA haplotype is a main focus of attention. Our case supports their hypothesis, and suggested that the complication occurred with immunological and genetic correlation. Anti-HTLV-1 antibody was positive at a titer of 1:8192 before exposure to CMO. On transferring to us, it was negative and revealed excessive positive at a titer of 1:20,480 on the 80th day. Immunoglobulin analysis was normal on admission and increased during hospitalization. It was reported that prenatal exposure to relatively mild concentrations of CMO in rats reduces splenic macrophage phagocytosis and killing ability as well as macrophage respiratory burst. These data suggested that PBC and Basedow's disease were manifested by exposure to carbon monoxide.
authors.affiliation: Division of Neurology, Faculty of Medicine, Tottori University, Yonago, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takigawa
authors.forename: H
authors.initials: H
authors.lastname: Kowa
authors.forename: M
authors.initials: M
authors.lastname: Kitayama
authors.forename: S
authors.initials: S
authors.lastname: Doi
authors.forename: S
authors.initials: S
authors.lastname: Araga
authors.forename: K
authors.initials: K
authors.lastname: Nakashima
mesh_terms: D000208:Acute Disease; D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000150:complications*; D005260:Female; D006111:Graves Disease / Q000209:etiology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000209:etiology*; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000150:complications*; D051381:Rats