title: F-18 fluoro deoxyglucose SPECT for assessment of myocardial viability.
abstract: Identification of myocardial viability in hypokinetic segments is important in patients with ischemic cardiomyopathy because systolic dysfunction improves with revascularization. Positron emission tomography (PET) F-18 fluoro deoxyglucose (FDG) uptake has been demonstrated as an accurate indicator of metabolically active and thus viable myocardium. F-18 FDG single photon emission computed tomography (SPECT) has recently been introduced and offers a technically easier and less costly alternative to PET imaging for determination of myocardial viability. A body of literature demonstrates that F-18 FDG SPECT can reliably be performed with SPECT hardware equipped with 511-keV collimators, which provides an accurate assessment of myocardial viability. F-18 FDG SPECT offers data similar to those offered by F-18 FDG PET and compares favorably with other imaging modalities, including rest-redistribution and stress-reinjection thallium-201 myocardial perfusion imaging, gated technetium 99m SPECT, and low-dose dobutamine echocardiography.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA.
authors.forename: J
authors.initials: J
authors.lastname: Fitzgerald
authors.forename: J A
authors.initials: JA
authors.lastname: Parker
authors.forename: P G
authors.initials: PG
authors.lastname: Danias
mesh_terms: D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000000981:diagnostic imaging; D017682:Myocardial Stunning / Q000000981:diagnostic imaging* / Q000209:etiology; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18