Analgesic activity of cyclic imides: 1,8-naphthalimide and 1,4,5,8-naphthalenediimide derivatives.
In early studies, we have reported the synthesis and biological activities of several cyclic imides. The present study describes the analgesic activity of 1,8-naphthalimide and 1,4,5,8-naphthalenediimide derivatives in a standard murine model of analgesia. The pharmacological results show that all compounds studied, given intraperitoneally, produced significant inhibition of acetic acid-induced abdominal constrictions. At the ID50 (micromol/kg) level, these cyclic imide derivatives were about 40-270-fold more potent in this assay than aspirin and acetaminophen, two well-known and widely used analgesics. These results extend previous studies on the analgesic activity of cyclic imides.
Andricopulo
A D
AD
Department of Chemistry, Universidade Federal de Santa Catarina, Florianópolis, Brazil. aandrico@umich.edu
Müller
L A
LA
Filho
V C
VC
Cani
G S
GS
Roos
J F
JF
Corrêa
R
R
Santos
A R
AR
Nunes
R J
RJ
Yunes
R A
RA
D015057:1-Naphthylamine / Q000031:analogs & derivatives*; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007094:Imides / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure
D000700:Analgesics; D007094:Imides; D015057:1-Naphthylamine