title: [Gene therapy of liver tumors].
abstract: The aim of this review is to describe current possibilities of gene therapy in liver tumours. The authors discuss the following methods which were used in experimental clinical trials: tumour suppressor genes, suicide gene therapy, immunogene therapy and use of oncolytic viruses. The results from these first clinical trials were encouraging. However, because of the present limitations, such as safe transport and selective expression of genes in the malignant cells, gene therapy cannot be used as a definitive treatment for liver tumours.
authors.affiliation: I. chirurgická klinika UP, Olomouc.
authors.forename: R
authors.initials: R
authors.lastname: Havlík
authors.forename: V
authors.initials: V
authors.lastname: Král
mesh_terms: D015316:Genetic Therapy; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*