title: Outcome of invasive pneumococcal disease: a UK based study. Oxford Pneumococcal Surveillance Group.
abstract: METHODS
  The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed.
  
  
  RESULTS
  The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials.
  
  
  CONCLUSIONS
  These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.
authors.affiliation: Oxford Vaccine Group, University of Oxford, UK.
authors.forename: F
authors.initials: F
authors.lastname: Shackley
authors.forename: K
authors.initials: K
authors.lastname: Knox
authors.forename: J B
authors.initials: JB
authors.lastname: Morris
authors.forename: D
authors.initials: D
authors.lastname: Crook
authors.forename: D
authors.initials: D
authors.lastname: Griffiths
authors.forename: R
authors.initials: R
authors.lastname: Mayon-White
authors.forename: R
authors.initials: R
authors.lastname: George
authors.forename: L
authors.initials: L
authors.lastname: Willocks
authors.forename: E
authors.initials: E
authors.lastname: Moxon
mesh_terms: D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011008:Pneumococcal Infections / Q000150:complications / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013296:Streptococcus pneumoniae / Q000145:classification / Q000302:isolation & purification; D006113:United Kingdom / Q000453:epidemiology