Infrared spectroscopy of human cells and tissue. VIII. Strategies for analysis of infrared tissue mapping data and applications to liver tissue.
Experimental and computational methods of infrared microspectroscopy (IRI-MSP) and infrared spectral mapping (ISM) are presented. These methods are subsequently applied to the analysis of cirrhotic liver tissue. The sensitivity of infrared spectral mapping toward spectral changes caused by disease will be demonstrated. In addition, the excellent agreement between ISM data and histopathological information will be discussed.
Diem
M
M
Department of Chemistry and Biochemistry, City University of New York, Hunter College, New York 10021, USA. mdiemhc@aol.com
Chiriboga
L
L
Yee
H
H
D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008099:Liver / Q000737:chemistry* / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology; D008722:Methods; D015591:Microspectrophotometry / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods