Prostatic steroid 5 alpha-reductase, an androgen metabolic gene.
Prostate cancer risk is highest in African Americans, lowest in Asians, and intermediate in Caucasians and Latinos. The data clearly suggest that environmental and genetic factors are involved. Investigation of the genetic factors suggests that allelic variation in the SRD5A2 gene is partially responsible for the striking racial and ethnic variations in risk.
Reichardt
J K
JK
Department of Biochemistry and Molecular Biology, USC School of Medicine, Los Angeles, USA.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000235:genetics*; D019943:Amino Acid Substitution; D000728:Androgens / Q000235:genetics* / Q000378:metabolism*; D001213:Asian / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D015331:Cohort Studies; D014644:Genetic Variation / Q000235:genetics*; D006254:Hawaii / Q000453:epidemiology; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D011795:Surveys and Questionnaires; D044465:White People / Q000235:genetics*; D001741:Black or African American
D000728:Androgens; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase