title: Decreased linear growth associated with intestinal bladder augmentation in children with bladder exstrophy.
abstract: OBJECTIVE
  We determine if enterocystoplasty results in delayed linear growth using a case controlled study to observe the effects of intestinal bladder augmentation on growth in patients with bladder exstrophy.
  
  
  METHODS
  A total of 50 patients who had undergone bladder augmentation for incontinence due to classic bladder exstrophy were selected from our patient database and matched for gender, age and type of exstrophy with 50 patients who had nonaugmented bladder exstrophy. Patients were then contacted and asked to permit the pediatricians to release growth charts. Once consent was obtained the charts were requested from the pediatricians, and evaluable data, defined as at least 1 height before and after augmentation, were obtained for 17 of 50 (34%) augmented and 15 of 50 (30%) nonaugmented cases.
  
  
  RESULTS
  Mean age at surgery was 7.7 years. Delayed growth as defined by a postoperative decrease in percentile height occurred in 14 of 17 (82%) augmented cases (mean loss 15.6 percentile points). Delayed growth after age 7.7 years occurred in 5 of 15 (33%) controls but average growth for the entire group was 6.7 percentile points (p = 0. 014). Mean followup was 5.7 years (median 4.9) for the augmented group and 7.3 years (median 8.2) for the control group.
  
  
  CONCLUSIONS
  Intestinal bladder augmentation is associated with a nearly universal decrease in percentile height. Close long-term followup of these patients and analysis of subtle metabolic alterations may provide information to help minimize or prevent growth impediment in the future.
authors.affiliation: Division of Pediatric Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Gros
authors.forename: J L
authors.initials: JL
authors.lastname: Dodson
authors.forename: U A
authors.initials: UA
authors.lastname: Lopatin
authors.forename: J P
authors.initials: JP
authors.lastname: Gearhart
authors.forename: R I
authors.initials: RI
authors.lastname: Silver
authors.forename: S G
authors.initials: SG
authors.lastname: Docimo
mesh_terms: D000293:Adolescent; D001746:Bladder Exstrophy / Q000601:surgery*; D001827:Body Height; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007223:Infant; D008297:Male; D011184:Postoperative Period; D001743:Urinary Bladder / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000009:adverse effects*