Antifungal activity of Hinokitiol-related compounds on wood-rotting fungi and their insecticidal activities.
Hinokitiol (beta-thujaplicin), beta-dolabrin and gamma-thujaplicin isolated from Thujopsis dolabrata SIEB. et ZUCC var hondai MAKINO showed antifungal activities against all of the wood-rotting fungi examined. The antifungal activity of three compounds on Daedalea dickinsii IFO-4979 was especially strong, their minimum inhibitory concentration (MIC) values being 0.2 microg/ml. Their antifungal activities on D. dickinsii IFO-4979 were as high as that of amphotericin B used as a positive control. Three compounds had strong insecticidal activities on Tyrophagus putrescentiae [50%-lethal concentration (LC50 : g/m2) 0.25 in hinokitiol, 0.02 in beta-dolabrin and gamma-thujaplicin. Their insecticidal activities were higher than that of N,N-diethyl-m-toluamide (DEET, LC50 : 1.46 g/m2) used as a positive control. Three compounds also showed strong insecticidal activity on Coptotermes formosanus [LC50 (g/m2) 0.07 in hinokitiol, 0.05 in beta-dolabrin and gamma-thujaplicin], although their insecticidal activities were much lower than that of commercial chloropyrifos (LC50 : 0.00016 g/m2).
Inamori
Y
Y
Osaka University of Pharmaceutical Sciences, Nasahara, Takatsuki, Japan.
Sakagami
Y
Y
Morita
Y
Y
Shibata
M
M
Sugiura
M
M
Kumeda
Y
Y
Okabe
T
T
Tsujibo
H
H
Ishida
N
N
D000935:Antifungal Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000187:drug effects*; D007306:Insecticides / Q000494:pharmacology*; D039821:Monoterpenes; D010944:Plants; D014334:Tropolone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000935:Antifungal Agents; D007306:Insecticides; D039821:Monoterpenes; D014334:Tropolone; C009479:beta-thujaplicin