title: [Falls, frailty and osteoporosis in the elderly: a public health problem].
abstract: BACKGROUND
  Elderly people can be subdivided into three groups: healthy elderly persons (65-70% of the population), elderly subjects with diseases (about 5%) and frail old people. Frailty represents "age-related physiologic vulnerability resulting from impaired homeotasic stock and a reduced capacity of the organism to withstand stress". It could lead elderly subjects to pathological, barely reversible, ageing.
  
  
  BACKGROUND
  One of the main objective of geriatricians is to develop useful screening tools to identify people at high risk, thus allowing them to benefit from preventive interventions as early as possible. It has been suggested that the decline in homeostatic stock involves numerous physiological systems. Those at the core of frailty would be neuromuscular changes resulting in sarcopenia, neuroendocrine dysregulation, and immune disorders. A recent study has shown that increased levels of interleukin 6 is a risk factor for frailty.
  
  
  CONCLUSIONS
  Work in progress aimed at identification of at-risk patients should: lead to early detection; draw attention on underestimated fields such as the nutritional status, sarcopenia, or gait disorders; promote the development of the standardized gerontological evaluation in order to identify the different components of frailty; and promote the development of non-pharmacological programmes including physical training, nutritional managing, and optimal social life.
authors.affiliation: Service de médecine interne et gérontologie clinique, hôpital Purpan-Casselardit, CHU, Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Vellas
authors.forename: S
authors.initials: S
authors.lastname: Gillette-Guyonnet
authors.forename: F
authors.initials: F
authors.lastname: Nourhashémi
authors.forename: Y
authors.initials: Y
authors.lastname: Rolland
authors.forename: S
authors.initials: S
authors.lastname: Lauque
authors.forename: P J
authors.initials: PJ
authors.lastname: Ousset
authors.forename: S
authors.initials: S
authors.lastname: Moulias
authors.forename: S
authors.initials: S
authors.lastname: Andrieu
authors.forename: B
authors.initials: B
authors.lastname: Fontan
authors.forename: D
authors.initials: D
authors.lastname: Adoue
authors.forename: C
authors.initials: C
authors.lastname: Lafont
authors.forename: R
authors.initials: R
authors.lastname: Baumgartner
authors.forename: P
authors.initials: P
authors.lastname: Garry
authors.forename: J L
authors.initials: JL
authors.lastname: Albarède
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control; D000368:Aged; D005260:Female; D016330:Frail Elderly; D005853:Geriatrics; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D011634:Public Health; D012307:Risk Factors