A water-cooled spherical niobium target for the production of [18F]fluoride.
A new automated target system for the routine production of [18F]fluoride from (18)O-enriched water has been constructed. It consists of a small spherical niobium target chamber mounted into a special holder, which provides rapid cooling by water flow around the sphere. The target is irradiated with 21 MeV protons; the incident energy in the target chamber is 13 MeV. The system is operated without external over-pressure and has been tested for beam currents up to 50 microA. 95% of the theoretical yield of [18F]fluoride has been extracted and used for the synthesis of [18F]2-fluoro-2-deoxy-D-glucose.
Zeisler
S K
SK
German Cancer Research Center (DKFZ), Department of Radiochemistry, Heidelberg. zeisler@dkfz-heidelberg.de
Becker
D W
DW
Pavan
R A
RA
Moschel
R
R
Rühle
H
H
D005459:Fluorides / Q000138:chemical synthesis*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009556:Niobium; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D014867:Water
D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D009556:Niobium; D014867:Water; D019788:Fluorodeoxyglucose F18; D005459:Fluorides