Radiochemical separation of no-carrier-added 177Lu as produced via the 176Yb(n,gamma)177Yb-->177Lu process.
The 176Yb(n,gamma)177Yb-beta(-)-->177Lu process was investigated to provide no-carrier-added (nca) 177Lu. The radiochemical separation of the 177Lu from the macro-amounts of the ytterbium target based on the cementation process, i.e. the selective extraction of Yb by Na(Hg) amalgam from Cl-/CH3COO- electrolytes, followed by a final cation exchange purification. The cementation separation process provides a decontamination factor of Yb(III) of 10(4), the cation exchange purification adding a decontamination factor of > 10(2). The nca 177Lu is available in radiochemically pure form despite the chemical similarity of the lanthanides with 75 +/- 5% overall separation yield within 4-5 h. It can be used to synthesise nca 177Lu labelled radiotherapeuticals.
Lebedev
N A
NA
Laboratory for Nuclear Problems, JINR Dubna, Russian Federation.
Novgorodov
A F
AF
Misiak
R
R
Brockmann
J
J
Rösch
F
F
D002852:Chromatography, Ion Exchange / Q000379:methods; D007202:Indicators and Reagents; D007554:Isotopes; D008187:Lutetium / Q000737:chemistry* / Q000302:isolation & purification; D011868:Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D015018:Ytterbium / Q000737:chemistry*
D007202:Indicators and Reagents; D007554:Isotopes; D011868:Radioisotopes; D008187:Lutetium; D015018:Ytterbium