title: [(18)F]p-MPPF: aA radiolabeled antagonist for the study of 5-HT(1A) receptors with PET.
abstract: This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism.
authors.affiliation: Cyclotron Research Center, Liège University, Sart Tilman B.30, B-4000 Liège, Belgium. Alain.Plenevaux@ulg.ac.be
authors.forename: A
authors.initials: A
authors.lastname: Plenevaux
authors.forename: C
authors.initials: C
authors.lastname: Lemaire
authors.forename: J
authors.initials: J
authors.lastname: Aerts
authors.forename: G
authors.initials: G
authors.lastname: Lacan
authors.forename: D
authors.initials: D
authors.lastname: Rubins
authors.forename: W P
authors.initials: WP
authors.lastname: Melega
authors.forename: C
authors.initials: C
authors.lastname: Brihaye
authors.forename: C
authors.initials: C
authors.lastname: Degueldre
authors.forename: S
authors.initials: S
authors.lastname: Fuchs
authors.forename: E
authors.initials: E
authors.lastname: Salmon
authors.forename: P
authors.initials: P
authors.lastname: Maquet
authors.forename: S
authors.initials: S
authors.lastname: Laureys
authors.forename: P
authors.initials: P
authors.lastname: Damhaut
authors.forename: D
authors.initials: D
authors.lastname: Weissmann
authors.forename: D
authors.initials: D
authors.lastname: Le Bars
authors.forename: J F
authors.initials: JF
authors.lastname: Pujol
authors.forename: A
authors.initials: A
authors.lastname: Luxen
mesh_terms: D000631:Aminopyridines / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry; D002415:Cats; D005462:Fluorine Radioisotopes; D006801:Humans; D008024:Ligands; D010879:Piperazines / Q000378:metabolism*; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis*; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D000631:Aminopyridines; D005462:Fluorine Radioisotopes; D008024:Ligands; D010879:Piperazines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; C099463:4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine