Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system.
A subset of stem-like cells from bone marrow that are referred to as marrow stromal cells (MSCs) have been shown to be capable of differentiating into osteoblasts, chondrocytes, adipocytes, myocytes, astrocytes and perhaps neurons. Recently, conditions have been developed where human MSCs can be expanded almost without limit in culture without apparently losing their multipotentiality for differentiation. The cells appear to be potentially useful for the repair of extracellular matrix and the central nervous system.
Prockop
D J
DJ
Center for Gene Therapy, MCP Hahnemann University, 10118 New College Building, 245 North 15 St., Philadelphia, PA 19102, USA. darwin.prockop@drexel.edu
Azizi
S A
SA
Colter
D
D
Digirolamo
C
C
Kopen
G
G
Phinney
D G
DG
D000818:Animals; D001847:Bone Diseases / Q000628:therapy*; D001854:Bone Marrow Cells / Q000166:cytology*; D001921:Brain / Q000378:metabolism; D002454:Cell Differentiation; D002478:Cells, Cultured; D002490:Central Nervous System / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000628:therapy*; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008822:Mice, Transgenic; D009135:Muscular Diseases / Q000628:therapy*; D009474:Neurons / Q000378:metabolism; D051381:Rats; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*