Inhibition of lipogenesis by pycnogenol.
The influence of pycnogenol on the adipose conversion of 3T3-L1 cells by insulin was studied. In week 3 of culture with insulin, pycnogenol was found to inhibit significantly the expression of glycerophosphate dehydrogenase (p < 0.01). This finding suggests that pycnogenol inhibits the accumulation of lipid droplets in adipose tissue.
Hasegawa
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Department of Food and Nutrition, Nagoya Bunri College, Nagoya, Japan. hsgwn@nagoya-bunri.ac.jp
D016475:3T3 Cells; D017667:Adipocytes / Q000187:drug effects; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D005993:Glycerolphosphate Dehydrogenase / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin; D008066:Lipolysis / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology
D005419:Flavonoids; D000960:Hypolipidemic Agents; D007328:Insulin; D010936:Plant Extracts; C024070:pycnogenols; D005993:Glycerolphosphate Dehydrogenase