Follicular dendritic cells in TSE pathogenesis.
The pathogenesis of transmissible spongiform encephalopathies (TSEs) often includes a replication phase in lymphoid tissues before infection spreads to the central nervous system. Recent studies show that the follicular dendritic cells of the germinal centres are critical for this replication. These cells are therefore potential targets for therapy or prophylaxis in natural TSEs, such as variant Creutzfeldt-Jakob disease.
Bruce
M E
ME
Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh UK EH9 3JF. moira.bruce@bbsrc.ac.uk
Brown
K L
KL
Mabbott
N A
NA
Farquhar
C F
CF
Jeffrey
M
M
D000818:Animals; D007562:Creutzfeldt-Jakob Syndrome / Q000209:etiology*; D020566:Dendritic Cells, Follicular / Q000502:physiology*; D016643:Encephalopathy, Bovine Spongiform / Q000209:etiology*; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D011328:Prions / Q000502:physiology; D012608:Scrapie / Q000209:etiology*
D011328:Prions