Protein-losing enteropathy associated with hypocomplementemia and anti-nuclear antibodies.
We report a case of protein-losing enteropathy associated with an autoimmune disorder, presumably systemic lupus erythematosus. Although typical manifestations of systemic lupus erythematosus were lacking, a high serum cholesterol level, a low serum complement level, positivity for anti-nuclear antibody, and positivity for anti-single-strand DNA antibody suggested an autoimmune mechanism as the cause of the condition. Although immunohistological examination of duodenal and ileal biopsy specimens failed to reveal deposits of immune complex or complement in the vessels, capillary hyperpermeability was suspected as the mechanism of the condition.
Nakajima
A
A
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Ohnishi
S
S
Mimura
T
T
Kubo
K
K
Suzuki
A
A
Yazaki
Y
Y
Matsuhashi
N
N
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D002199:Capillary Permeability; D002784:Cholesterol / Q000097:blood; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000175:diagnosis; D011504:Protein-Losing Enteropathies / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D011877:Radionuclide Imaging
D000974:Antibodies, Antinuclear; D003165:Complement System Proteins; D002784:Cholesterol