title: A water-cooled spherical niobium target for the production of [18F]fluoride.
abstract: A new automated target system for the routine production of [18F]fluoride from (18)O-enriched water has been constructed. It consists of a small spherical niobium target chamber mounted into a special holder, which provides rapid cooling by water flow around the sphere. The target is irradiated with 21 MeV protons; the incident energy in the target chamber is 13 MeV. The system is operated without external over-pressure and has been tested for beam currents up to 50 microA. 95% of the theoretical yield of [18F]fluoride has been extracted and used for the synthesis of [18F]2-fluoro-2-deoxy-D-glucose.
authors.affiliation: German Cancer Research Center (DKFZ), Department of Radiochemistry, Heidelberg. zeisler@dkfz-heidelberg.de
authors.forename: S K
authors.initials: SK
authors.lastname: Zeisler
authors.forename: D W
authors.initials: DW
authors.lastname: Becker
authors.forename: R A
authors.initials: RA
authors.lastname: Pavan
authors.forename: R
authors.initials: R
authors.lastname: Moschel
authors.forename: H
authors.initials: H
authors.lastname: Rühle
mesh_terms: D005459:Fluorides / Q000138:chemical synthesis*; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009556:Niobium; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D014867:Water
chemical_list: D005462:Fluorine Radioisotopes; D007202:Indicators and Reagents; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D009556:Niobium; D014867:Water; D019788:Fluorodeoxyglucose F18; D005459:Fluorides