Correlation of radiation tolerance dose of normal human organs with organ weight, blood, and water content.
The concerted effort to minimize the radiation exposure to normal human tissues while delivering a high radiation dose to the tumor often results in complications. This limits the efficacy of radiation treatment. Analysis of radiation tolerance dose with organ weight in 15 human organs yields a correlation coefficient of 0.62, whereas the correlation of radiation tolerance dose with blood and water content yields correlation coefficients of 0.82 and 0.60, respectively. Results indicate that as the organ weight and/or blood and water content increases, radiation tolerance dose decreases.
Akber
S F
SF
Department of Radiology, Craven Regional Medical Center, New Bern, North Carolina 28561, USA.
D001769:Blood / Q000528:radiation effects; D001834:Body Water / Q000528:radiation effects; D001842:Bone and Bones / Q000528:radiation effects; D001921:Brain / Q000528:radiation effects; D004064:Digestive System / Q000528:radiation effects; D005260:Female; D005836:Genitalia, Female / Q000528:radiation effects; D006321:Heart / Q000528:radiation effects; D006801:Humans; D007830:Larynx / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D009929:Organ Size / Q000528:radiation effects; D017933:Peripheral Nervous System / Q000528:radiation effects; D011830:Radiation Effects; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012679:Sense Organs / Q000528:radiation effects; D013284:Stomatognathic System / Q000528:radiation effects; D013961:Thyroid Gland / Q000528:radiation effects; D014551:Urinary Tract / Q000528:radiation effects