title: MR patterns of hypoxic-ischemic brain damage after prenatal, perinatal or postnatal asphyxia.
abstract: The relationship between MR patterns of brain damage and type or timing of perinatal hypoxia-ischemia was studied. MR images of 104 children with evidence of bilateral posthypoxic-ischemic brain damage and neonatal records were reviewed. Three different MR patterns were found. Periventricular leukomalacia occurred in 73 children, in 82% after a history of subacute or chronic hypoxia-ischemia, in 71% after preterm birth. Predominant lesions of basal ganglia and thalamus occurred in 21 children, in 95% preceded by acute profound asphyxia, in 85% after term birth. Multicystic encephalopathy occurred in 10 infants, in 70% preceded by mild signs of hypoxia-ischemia, followed by an unexpectedly severe encephalopathy, in 60% after term birth. Statistical analysis showed that the patterns of injury were primarily related to the type of hypoxia-ischemia. We conclude that the type of hypoxia-ischemia, rather than the postconceptional age at occurrence determines the pattern of brain injury.
authors.affiliation: Department of Child Neurology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: L T
authors.initials: LT
authors.lastname: Sie
authors.forename: M S
authors.initials: MS
authors.lastname: van der Knaap
authors.forename: J
authors.initials: J
authors.lastname: Oosting
authors.forename: L S
authors.initials: LS
authors.lastname: de Vries
authors.forename: H N
authors.initials: HN
authors.lastname: Lafeber
authors.forename: J
authors.initials: J
authors.lastname: Valk
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications*; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D005315:Fetal Diseases; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000209:etiology*; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging; D008297:Male; D010500:Perinatology; D012189:Retrospective Studies; D012307:Risk Factors