Synovial chondromatosis: the possible role of FGF 9 and FGF receptor 3 in its pathology.
Primary synovial chondromatosis (PSC) is a rare disorder of the synovium typified by cartilaginous nodule formation within the synovial membrane. Fibroblast growth factor receptor 3 (FGFR3) is a recently described specific marker of mesenchymal precartilaginous stem cells. Expression patterns of FGFR3 and its specific ligand, fibroblast growth factor 9 (FGF 9), were evaluated both in situ and in cell cultures. Histologically, cells at the periphery of the cartilage nodules express FGFR3 and PCNA (proliferating cell nuclear antigen). Elevated levels of FGF 9, its specific ligand, have been found in synovial fluids of patients with synovial chondromatosis. Synoviocytes but not chondrocytes from affected patients express FGF9 in culture. This pattern is absent in normal synovium and cartilage. Downregulation of FGF9 may provide a possible nonoperative therapy for PSC.
Robinson
D
D
Department of Orthopedic Surgery, Assaf Harofe Medical Center, Zeriffin 70300, Israel.
Hasharoni
A
A
Evron
Z
Z
Segal
M
M
Nevo
Z
Z
D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology; D018929:Cell Culture Techniques; D002455:Cell Division; D015838:Chondromatosis, Synovial / Q000378:metabolism* / Q000473:pathology; D051525:Fibroblast Growth Factor 9; D005346:Fibroblast Growth Factors; D006133:Growth Substances / Q000378:metabolism*; D006801:Humans; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011505:Protein-Tyrosine Kinases; D051498:Receptor, Fibroblast Growth Factor, Type 3; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology
C496459:FGF9 protein, human; D051525:Fibroblast Growth Factor 9; D006133:Growth Substances; D018809:Proliferating Cell Nuclear Antigen; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; C496365:FGFR3 protein, human; D011505:Protein-Tyrosine Kinases; D051498:Receptor, Fibroblast Growth Factor, Type 3