title: Infectious complications in critically injured children.
abstract: OBJECTIVE
  Infection will complicate the care of a significant number of injured adults. Trauma is the leading cause of mortality in the pediatric population, yet little information is available regarding the incidence of infection in this group. This study evaluates infectious complications in the critically injured child.
  
  
  METHODS
  All children admitted to the pediatric intensive care unit from an urban level-1 trauma center during an 80-consecutive-month period were studied. Infection was defined by Centers for Disease Control criteria and was identified by a retrospective review of the medical records. Demographic and clinical information, including microbiologic data, were compiled for all study patients. Data were analyzed using Student's (t)test or chi2 analysis where appropriate.
  
  
  RESULTS
  Five hundred twenty-three children were at risk for infection during the study period. Seventy-eight infections were documented in 53 children (incidence, 10.1%). Nosocomial infections accounted for 78% of these with a majority (85%) being device associated. Common infections in this group included lower respiratory (n = 35), primary bloodstream (n = 10), and urinary tract (n = 7). Trauma-related infections were primarily wound (n = 9), intraabdominal (n = 3), or central nervous system (n = 3). Bacterial pathogens predominated, and the most frequent microorganisms recovered were Staphylococcus aureus, Pseudomonas sp, and Haemophilus sp. Children with infectious complications were more severely injured (injury severity score [ISS] 24 versus 17, P < .001) and had a longer hospital stay (21 days v 6 days, P < .001) compared with children without infection during the same period. Overall mortality rate for the study group was 5.7% and was not significantly different from children without infection.
  
  
  CONCLUSIONS
  Infection is a significant source of morbidity in the critically injured child. Nosocomial infections predominate, and a majority of these are device related, emphasizing the need for continued vigilance toward prevention in this high-risk group.
authors.affiliation: Department of Surgery, University of Florida, Health Science Center Jacksonville, 32209-6511, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Patel
authors.forename: D L
authors.initials: DL
authors.lastname: Mollitt
authors.forename: J J
authors.initials: JJ
authors.lastname: Tepas
mesh_terms: D001424:Bacterial Infections / Q000453:epidemiology; D002404:Catheterization / Q000009:adverse effects; D002648:Child; D003428:Cross Infection / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D015601:Injury Severity Score; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data; D007440:Intubation / Q000009:adverse effects; D008297:Male; D012189:Retrospective Studies; D014946:Wound Infection / Q000453:epidemiology*; D014949:Wounds, Nonpenetrating / Q000150:complications*; D014950:Wounds, Penetrating / Q000150:complications*