title: Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus.
abstract: Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
authors.forename: J M
authors.initials: JM
authors.lastname: Entenza
authors.forename: T J
authors.initials: TJ
authors.lastname: Foster
authors.forename: D
authors.initials: D
authors.lastname: Ni Eidhin
authors.forename: P
authors.initials: P
authors.lastname: Vaudaux
authors.forename: P
authors.initials: P
authors.lastname: Francioli
authors.forename: P
authors.initials: P
authors.lastname: Moreillon
mesh_terms: D018829:Adhesins, Bacterial / Q000502:physiology*; D000818:Animals; D004697:Endocarditis, Bacterial / Q000209:etiology*; D005340:Fibrinogen / Q000378:metabolism*; D051381:Rats; D013203:Staphylococcal Infections / Q000209:etiology*
chemical_list: D018829:Adhesins, Bacterial; D005340:Fibrinogen