Asbestos exposure, lung cancer and asbestosis.
The relationship between asbestos exposure, lung cancer and asbestosis is reviewed. Studies have demonstrated the risk of lung cancer to be raised in asbestos-exposed workers whether asbestosis is present or not. Although increasing exposure increases the risk of disease, variability in estimation of fibre levels and in subject susceptibility should be borne in mind. Consensus opinion recommends that attribution of lung cancer to asbestos exposure should be based on clinical and occupational histories. The risk of lung cancer in those who both smoke and are exposed to asbestos is increased in a multiplicative way, putting subjects at very great risk.
Billings
C G
CG
Respiratory Function Unit, Royal Hallamshire Hospital, Sheffield, UK.
Howard
P
P
D000818:Animals; D001195:Asbestosis / Q000150:complications*; D004198:Disease Susceptibility; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure; D012307:Risk Factors; D012907:Smoking