title: Recent developments and future directions in computational genomics.
abstract: Computational genomics is a subfield of computational biology that deals with the analysis of entire genome sequences. Transcending the boundaries of classical sequence analysis, computational genomics exploits the inherent properties of entire genomes by modelling them as systems. We review recent developments in the field, discuss in some detail a number of novel approaches that take into account the genomic context and argue that progress will be made by novel knowledge representation and simulation technologies.
authors.affiliation: Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, UK.
authors.forename: S
authors.initials: S
authors.lastname: Tsoka
authors.forename: C A
authors.initials: CA
authors.lastname: Ouzounis
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000639:trends*; D003198:Computer Simulation; D019992:Databases as Topic; D005796:Genes / Q000235:genetics / Q000502:physiology; D016678:Genome; D006801:Humans; D005810:Multigene Family / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D011993:Recombinant Fusion Proteins