Mechanical evaluation and design of a multilayered collagenous repair biomaterial.
One method of fabricating implantable biomaterials is to utilize biologically derived, chemically modified tissues to form constructs that are both biocompatible and remodelable. Rigorous mechanical characterization is a necessary component in material evaluation to ensure that the constructs will withstand in vivo loading. In this study we performed an in-depth biaxial mechanical and quantitative structural analysis of GraftPatch (GP), a biomaterial constructed by assembling chemically treated layers of porcine small intestinal submucosa (SIS). The mechanical behavior of GP was compared to both native SIS and to glutaraldehyde-treated bovine pericardium (GLBP) as a reference biomaterial. Under biaxial loading, GP was found to be stiffer than native SIS and mechanically anisotropic, with the preferred fiber direction demonstrating greater stiffness. Quantitative structural analysis using small-angle light scattering indicated a uniform fiber structure similar to GLBP and SIS. To enable test-protocol-independent quantitative comparisons, the biaxial mechanical data were fit to an orthotropic constitutive model, which indicated a similar degree of mechanical anisotropy between the three groups. We also demonstrate how the constitutive model can be used to design layered biocomposite materials that can undergo large deformations.
Gloeckner
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DC
Tissue Mechanics Laboratory, Department of Bioengineering, 749 Benedum Hall, 3700 O'Hara Street, Pittsburgh, Pennsylvania 15261, USA.
Sacks
M S
MS
Billiar
K L
KL
Bachrach
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N
D000818:Animals; D001672:Biocompatible Materials; D002417:Cattle; D003094:Collagen; D007413:Intestinal Mucosa; D008954:Models, Biological; D019736:Prostheses and Implants; D013499:Surface Properties; D013552:Swine
D001672:Biocompatible Materials; D003094:Collagen