Determination of absolute configurations of amines and amino acids using nonchiral derivatizing agents (NCDA) and deuterium NMR.
Enantiomeric analysis and empirical determination of the absolute configuration of amines and amino acids can be easily performed using acetyl-d(3) chloride as a nonchiral derivatizing agent (deuterium probe) and deuterium NMR in a chiral solvent (Courtieu's method). In the case of amino acids, derivatization to amido esters, performed with methanol-d(4) and acetyl-d(3) chloride, gives a double opportunity for enantiomeric analysis.
Chalard
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P
Laboratoire SEESIB, UMR CNRS 6504, Université Blaise Pascal, 63177 Aubière Cedex, France. icanet@chimtp@univ-bpclermont.fr
Bertrand
M
M
Canet
I
I
Théry
V
V
Remuson
R
R
Jeminet
G
G
D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002918:Chymotrypsin; D003903:Deuterium; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008968:Molecular Conformation; D013237:Stereoisomerism
D000588:Amines; D000596:Amino Acids; D007202:Indicators and Reagents; D003903:Deuterium; D002918:Chymotrypsin