title: Effects of a short-term hypoenergetic diet on morphofunctional left ventricular parameters in centrally obese subjects. An echocardiographic study.
abstract: BACKGROUND
  We aimed to study centrally obese subjects without other diseases, to establish whether a short-term hypoenergetic balanced regimen is able to positively modify left ventricular (LV) patterns.
  
  
  METHODS
  We studied 32 obese subjects (out of 52 recruited for this study) with central fat distribution and without associated diseases. Each subject had undergone a moderately hypoenergetic diet for a four-month follow-up period and had a regular loss in weight. Some relevant clinical and echocardiographic parameters were evaluated. Baseline data and those evaluated at the end of the follow-up period were used for outcome analysis.
  
  
  RESULTS
  We found a considerable reduction in LV mass and other LV structural parameters including relative wall thickness (RWT). Moreover, we found an improvement of both LV ejection fraction and filling parameters. As regards the relation ship between parameter changes, LV mass was correlated to LV internal diameter and mainly to LV wall thickness. LV mass change was also correlated to a reduction of diastolic BP and RWT. Only improvements in LV filling were correlated to WHR reduction. None of the changes in cardiac variables resulted significantly correlated to BMI change. Other interesting correlations are reported in the text.
  
  
  CONCLUSIONS
  Our study points out that improvements in LV structure and function are rapidly possible with a moderately hypoenergetic regimen in obese otherwise healthy subjects. The main changes were those in LV wall thickness even if a more complex cardiovascular adjustment was recognised. All this could be very important to possibly prevent future cardiovascular events (including heart failure), so largely linked to obesity of central type.
authors.affiliation: Institute of Internal Medicine, University of Palermo, Italy. s.corrao@tiscalinet.it
authors.forename: S
authors.initials: S
authors.lastname: Corrao
authors.forename: S
authors.initials: S
authors.lastname: Arnone
authors.forename: R
authors.initials: R
authors.lastname: Scaglione
authors.forename: V
authors.initials: V
authors.lastname: Amato
authors.forename: G
authors.initials: G
authors.lastname: Amico
authors.forename: A
authors.initials: A
authors.lastname: Licata
authors.forename: G
authors.initials: G
authors.lastname: Licata
mesh_terms: D000328:Adult; D004452:Echocardiography; D002149:Energy Intake; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D013997:Time Factors; D016277:Ventricular Function, Left