Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay.
A pilot study on relationships of selected molecular factors [erbB-1, erbB-2, erbB-3, and c-myc oncogene average gene copy numbers (AGCN); steroid receptors and pS2 gene expression; tumor cells' DNA values] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay (ATP-CVA), was performed. Despite the relatively small number of patients, numerous correlations among the factors tested were found. Nevertheless, only c-myc gene dosage positively affected ex vivo chemosensitivity of tumors tested.
Vogt
U
U
European Laboratory Association Section Ibbenbüren, Germany. DRUVOGT@t-online.de
Falkiewicz
B
B
Bielawski
K
K
Bosse
U
U
Schlotter
C M
CM
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D018815:Genes, erbB; D016259:Genes, myc; D006801:Humans; D066298:In Vitro Techniques; D010051:Ovarian Neoplasms / Q000235:genetics*
D000970:Antineoplastic Agents; D000255:Adenosine Triphosphate