title: Use of coagulase gene (coa) repeat region nucleotide sequences for typing of methicillin-resistant Staphylococcus aureus strains.
abstract: Coagulase gene (coa) short sequence repeat region sequencing was used to measure relatedness among a collection of temporally and geographically diverse methicillin-resistant Staphylococcus aureus isolates. The results show that coa polymorphism is free of strong selective pressure and has a low index of variation that may be useful for long-term epidemiological investigations. coa typing is a useful addition to spa typing for analysis of S. aureus, including methicillin-resistant strains.
authors.affiliation: Public Health Research Institute, New York University School of Medicine, New York, New York 10016, USA.
authors.forename: B
authors.initials: B
authors.lastname: Shopsin
authors.forename: M
authors.initials: M
authors.lastname: Gomez
authors.forename: M
authors.initials: M
authors.lastname: Waddington
authors.forename: M
authors.initials: M
authors.lastname: Riehman
authors.forename: B N
authors.initials: BN
authors.lastname: Kreiswirth
mesh_terms: D000595:Amino Acid Sequence; D015373:Bacterial Typing Techniques; D001483:Base Sequence; D003030:Coagulase / Q000235:genetics*; D006801:Humans; D016106:Methicillin Resistance; D008969:Molecular Sequence Data; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013205:Staphylococcal Protein A / Q000235:genetics; D013211:Staphylococcus aureus / Q000145:classification* / Q000187:drug effects* / Q000235:genetics; D020080:Tandem Repeat Sequences
chemical_list: D003030:Coagulase; D013205:Staphylococcal Protein A