title: In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized.
abstract: The in vitro activity of trovafloxacin against 125 strains of Mycoplasma species and Ureaplasma urealyticum, including fluoroquinolone-susceptible and fluoroquinolone-resistant species, was compared to those of other fluoroquinolones, doxycycline, and erythromycin. The MIC at which 90% of isolates are inhibited for all fluoroquinolone-susceptible strains was 0.25 microg/ml. Whatever the associated mutations, trovafloxacin exhibited greater activity than the other fluoroquinolones tested against fluoroquinolone-resistant Mycoplasma hominis and U. urealyticum isolates.
authors.affiliation: Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, Bordeaux, France. cecile.bebear@u-bordeaux2.fr
authors.forename: C M
authors.initials: CM
authors.lastname: Bebear
authors.forename: H
authors.initials: H
authors.lastname: Renaudin
authors.forename: A
authors.initials: A
authors.lastname: Charron
authors.forename: D
authors.initials: D
authors.lastname: Gruson
authors.forename: M
authors.initials: M
authors.lastname: Lefrancois
authors.forename: C
authors.initials: C
authors.lastname: Bebear
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D019535:Mycoplasma hominis / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D009287:Naphthyridines / Q000494:pharmacology*; D015242:Ofloxacin / Q000494:pharmacology; D016990:Ureaplasma urealyticum / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D002939:Ciprofloxacin; D004917:Erythromycin; C080163:trovafloxacin; D015242:Ofloxacin; D004318:Doxycycline; C061363:sparfloxacin