Switching from simple to complex oscillations in calcium signaling.
We present a new model for calcium oscillations based on experiments in hepatocytes. The model considers feedback inhibition on the initial agonist receptor complex by calcium and activated phospholipase C, as well as receptor type-dependent self-enhanced behavior of the activated G(alpha) subunit. It is able to show simple periodic oscillations and periodic bursting, and it is the first model to display chaotic bursting in response to agonist stimulations. Moreover, our model offers a possible explanation for the differences in dynamic behavior observed in response to different agonists in hepatocytes.
Kummer
U
U
European Media Laboratory, 69118 Heidelberg, Germany. ursula.kummer@eml.villa-bosch.de
Olsen
L F
LF
Dixon
C J
CJ
Green
A K
AK
Bornberg-Bauer
E
E
Baier
G
G
D000331:Aequorin / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D002478:Cells, Cultured; D005246:Feedback; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D009991:Oscillometry; D051381:Rats; D017208:Rats, Wistar; D010738:Type C Phospholipases / Q000378:metabolism
D000331:Aequorin; D010738:Type C Phospholipases; D020962:Heterotrimeric GTP-Binding Proteins; D002118:Calcium