title: Transformation of triclosan by Trametes versicolor and Pycnoporus cinnabarinus.
abstract: We investigated the ability of Trametes versicolor and Pycnoporous cinnabarinus to metabolize triclosan. T. versicolor produced three metabolites, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-xylopyranoside, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-glucopyranoside, and 2,4-dichlorophenol. P. cinnabarinus converted triclosan to 2,4, 4'-trichloro-2'-methoxydiphenyl ether and the glucoside conjugate known from T. versicolor. The conjugates showed a distinctly lower cytotoxic and microbicidal activity than triclosan did.
authors.affiliation: Institute of Microbiology and Molecular Biology, Ernst-Moritz-Arndt-University, D-17487 Greifswald, Germany. kai.hundt@plasmaselect.com
authors.forename: K
authors.initials: K
authors.lastname: Hundt
authors.forename: D
authors.initials: D
authors.lastname: Martin
authors.forename: E
authors.initials: E
authors.lastname: Hammer
authors.forename: U
authors.initials: U
authors.lastname: Jonas
authors.forename: M K
authors.initials: MK
authors.lastname: Kindermann
authors.forename: F
authors.initials: F
authors.lastname: Schauer
mesh_terms: D000891:Anti-Infective Agents, Local / Q000378:metabolism; D001487:Basidiomycota / Q000254:growth & development / Q000378:metabolism*; D001673:Biodegradation, Environmental; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D014260:Triclosan / Q000378:metabolism*
chemical_list: D000891:Anti-Infective Agents, Local; D014260:Triclosan