title: Eccrine syringofibroadenoma in a patient with a burn scar ulcer.
abstract: A 72-year-old woman with a burn scar on the calves of both legs developed an ulcer on her right heel, surrounded by multiple verrucous nodules and plaques. She had experienced similar verrucous lesions on both legs in the burn scar areas. Although the clinical diagnosis was Marjolin's ulcer, histologically the ulcer region showed thick fibrous tissue without any atypical epithelial cells. The verrucous lesions were consistent with the diagnosis of eccrine syringofibroadenoma (ESFA). Moreover, an ESFA-like growth pattern was seen in the elevated margin of the ulcer. Our findings suggest that these lesions developed as a result of reactive eccrine duct hyperplasia followed by skin tissue remodelling.
authors.affiliation: Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba, Ibaraki 305-8575, Japan. eikoi@md.tsukuba.ac.jp
authors.forename: E
authors.initials: E
authors.lastname: Ichikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Fujisawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tateishi
authors.forename: S
authors.initials: S
authors.lastname: Imakado
authors.forename: F
authors.initials: F
authors.lastname: Otsuka
mesh_terms: D006607:Adenoma, Sweat Gland / Q000209:etiology* / Q000473:pathology; D000368:Aged; D002056:Burns / Q000150:complications*; D002921:Cicatrix / Q000209:etiology*; D003937:Diagnosis, Differential; D004439:Eccrine Glands / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications; D007871:Leg Ulcer / Q000209:etiology* / Q000473:pathology; D013544:Sweat Gland Neoplasms / Q000209:etiology* / Q000473:pathology