title: Evaluation of role of concentration and molecular weight of oat beta-glucan in determining effect of viscosity on plasma glucose and insulin following an oral glucose load.
abstract: Data from clinical studies established that there was an inverse linear relationship between measures of postprandial blood glucose and insulin responses to an oral glucose load, consumed in a drink, and the logarithm of viscosity of the drink. These data have been re-analysed using concentration and molecular weight as the dependent variables. Molecular weight (M) of the beta-glucans used was determined using high-performance size exclusion chromatography equipped with a triple detector system of right angle light scattering, viscometry and refractive index. A significant relationship between changes in peak blood glucose and a combination of logarithm of the concentration and logarithm of M was found.
authors.affiliation: Agriculture and Agri-Food Canada, Southern Crop Protection and Food Research Centre, Guelph, Ontario, Canada. woodp@em.agr.ca
authors.forename: P J
authors.initials: PJ
authors.lastname: Wood
authors.forename: M U
authors.initials: MU
authors.lastname: Beer
authors.forename: G
authors.initials: G
authors.lastname: Butler
mesh_terms: D000284:Administration, Oral; D000465:Algorithms; D001786:Blood Glucose / Q000378:metabolism*; D005936:Glucans / Q000737:chemistry*; D005947:Glucose / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007328:Insulin / Q000097:blood; D008970:Molecular Weight; D014783:Viscosity; D047071:beta-Glucans
chemical_list: D001786:Blood Glucose; D005936:Glucans; D007328:Insulin; D047071:beta-Glucans; C067858:beta-glucan, (1-3)(1-4)-; D005947:Glucose