Mechanism of oestrogen signalling with particular reference to the role of ER beta in the central nervous system.
The discovery of a second oestrogen receptor (ER), ER beta, has drastically changed our view of oestrogen action. Since the two ERs, ER alpha and ER beta, have somewhat different tissue and cellular distribution as well as ligand binding specificity the possibility exists that they have different biological roles. Indeed, several observations seem to indicate that they may even have opposite effects so that ER beta diminishes the activity of ER alpha. The CNS contains both ER alpha and ER beta and it is conceivable that they may have specific and individual roles in oestrogen signalling in the brain.
Treuter
E
E
Karolinska Institutet, Department of Biosciences at Novum, Huddinge, Sweden.
Warner
M
M
Gustafsson
J A
JA
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism; D002319:Cardiovascular System; D002490:Central Nervous System / Q000378:metabolism* / Q000502:physiology; D047629:Estrogen Receptor beta; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D018377:Neurotransmitter Agents / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D051958:Nuclear Receptor Coactivator 2; D000078723:Nuclear Receptor Interacting Protein 1; D018384:Oxidative Stress; D017434:Protein Structure, Tertiary; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D001057:Apolipoproteins E; D047629:Estrogen Receptor beta; D004967:Estrogens; D008024:Ligands; D018377:Neurotransmitter Agents; D009687:Nuclear Proteins; D051958:Nuclear Receptor Coactivator 2; D000078723:Nuclear Receptor Interacting Protein 1; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D014157:Transcription Factors; C099713:nuclear receptor subfamily 0, group B, member 2