Effect of carnosine administration on certain metabolic parameters in bilharzial infected hamsters.
This study was designed to test the ability of carnosine to cure the metabolic disturbances induced by Schistosoma mansoni parasite. Results indicate that parasitic infection caused elevation of liver weight/body weight of S. mansoni infected hamsters, induced lipid peroxidation and reduced glycogen level. Moreover, the adenylate energy charge (AEC), ATP/ADP and ATP/AMP concentration ratios were markedly lower in infected hamsters. Administration of carnosine (10 mg/day) for 15 days either concurrent with infection, 2 and 4 weeks post exposure was effective in reducing worm burden and egg count only when given at the time of infection. It was also effective in renormalizing most of the measured parameters confirming the glycogen repletion, the antioxidant and AEC correcting actions of carnosine.
Soliman
K M
KM
Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt.
el-Ansary
A K
AK
Mohamed
A M
AM
D000818:Animals; D002336:Carnosine / Q000008:administration & dosage / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D008297:Male; D012555:Schistosomiasis mansoni / Q000188:drug therapy*
D002336:Carnosine