Tolerance of nonsteroidal antiinflammatory drugs in patients with inflammatory bowel disease.
OBJECTIVE
We sought to examine whether use of nonsteroidal antiinflammatory drugs (NSAIDs) in an outpatient inflammatory bowel disease (IBD) population is associated with an increased likelihood of active disease.


METHODS
We reviewed records of initial outpatient visits of IBD patients to the principal author from June 1995 to December 1997, with regard to use of aspirin and other NSAIDs and disease activity.


RESULTS
Of 40 Crohn's patients seen with active disease, three (7.5%) were using NSAIDs; 14 of 72 (19.4%) Crohn's patients seen with inactive disease were using NSAIDs. Fifty-eight ulcerative colitis patients were seen with active disease, with eight (13.7%) using NSAIDs. Among 21 UC patients initially seen while in remission, five (23.8%) were using NSAIDs.


CONCLUSIONS
Among this group of outpatients, NSAID use was not associated with a higher likelihood of active IBD. NSAID use in IBD deserves further study before recommending that patients refrain from their use under all circumstances.
Bonner
G F
GF
Department of Gastroenterology, Cleveland Clinic Florida and the School of Public Health, Nova-Southeastern University, Fort Lauderdale 33309, USA.
Walczak
M
M
Kitchen
L
L
Bayona
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000503:physiopathology; D003424:Crohn Disease / Q000188:drug therapy / Q000503:physiopathology; D004363:Drug Utilization; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D008499:Medical Records; D008875:Middle Aged; D012189:Retrospective Studies
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin