Risk factors for occlusion of infrainguinal bypass grafts.
OBJECTIVE
to identify risk factors for infrainguinal bypass occlusion and quantify the predictive value of data available before and after surgery.


METHODS
prospective study of 2650 patients who participated in a randomised trial of oral anticoagulants or aspirin after infrainguinal bypass surgery.


METHODS
risk factors were determined by univariate Cox regression analysis, and entered in multivariate analyses which distinguished two models: analysis of factors available from history and clinical examination, completed by radiological and surgical data in the second model. To compare the information content of the two models, receiver-operator characteristic (ROC) curves were computed.


RESULTS
in all patients female gender, critical ischaemia, femorocrural bypass grafting and non-venous graft material were independent risk factors. In patients with femoropopliteal bypasses female gender, critical ischaemia, poor run-off and non-venous graft material, the latter even in patients with supragenicular bypasses, were independent risk factors. The only significant risk factor in patients with femorocrural bypass grafts was use of a non-venous graft. The information contained in the first model was poor, whereas the second model had a higher predictive value.


CONCLUSIONS
the major risk factor, even in above-knee bypasses, is non-venous graft material. The venous bypass graft should be offered to patients whenever possible.
Tangelder
M J
MJ
Department of Vascular Surgery, University Hospital Utrecht, Utrecht, The Netherlands.
Algra
A
A
Lawson
J A
JA
Eikelboom
B C
BC
D000368:Aged; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D005260:Female; D005263:Femoral Artery / Q000601:surgery*; D005268:Femoral Vein / Q000601:surgery*; D006083:Graft Occlusion, Vascular / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016491:Peripheral Vascular Diseases / Q000601:surgery*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012372:ROC Curve; D015203:Reproducibility of Results; D012307:Risk Factors; D012501:Saphenous Vein / Q000637:transplantation; D012737:Sex Factors