Familiality of triglyceride and LPL response to exercise training: the HERITAGE study.
OBJECTIVE
The main purpose of the present investigation was to test whether and to what extent familial/genetic factors are involved in the changes of postheparin lipoprotein lipase (deltaPH-LPL) activity and triglyceride (deltaTG) levels in response to exercise training. Additional hypotheses were also tested as to whether there were familial/genetic factors shared by baseline and the corresponding response to exercise training (i.e., by baseline triglyceride (TG(B)) and deltaTG and by baseline postheparin lipoprotein lipase (PH-LPL(B)) and deltaPH-LPL activity).


METHODS
Serum TG and PH-LPL were measured in 459 subjects from 99 sedentary Caucasian families of the HERITAGE Family study before (baseline) and after completing a 20 wk (3 times per week) exercise training protocol. The training protocol had a target intensity of 75% of the heart rate associated with baseline VO2max during the last 6 wk. PH-LPL activity was measured in the study subjects. Both univariate and bivariate familial correlation analyses were applied to the baseline and response data.


RESULTS
The maximal heritabilities for deltaTG and deltaPH-LPL activity were 22% and 15%, respectively. There were no common familial factors for TG(B) and deltaTG, nor were there any for PH-LPL(B) and deltaPH-LPL. However, we found that there were common familial factors underlying deltaTG and deltaPH-LPL; these familial factors seemed to differ across sex and generation groups.


CONCLUSIONS
Although there were no common familial factors underlying the covariation between the baseline triglyceride and PH-LPL activity and the corresponding responses to exercise training (i.e., TG(B) with deltaTG or PH-LPL(B) with deltaPH-LPL), the deltaTG and deltaPH-LPL covariation apparently share some common familial determinants.
Hong
Y
Y
Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA. yuling@wubios.wustl.edu
Rice
T
T
Gagnon
J
J
Pérusse
L
L
Province
M
M
Bouchard
C
C
Leon
A S
AS
Skinner
J S
JS
Wilmore
J H
JH
Rao
D C
DC
Després
J P
JP
D000293:Adolescent; D000328:Adult; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D008071:Lipoprotein Lipase