An expedient route to the Calabar bean alkaloids (-)-physovenine and (-)-physostigmine.
An expedient route to the Calabar bean alkaloids (-)-physovenine and (-)-physostigmine has been devised using a chiral building block which was originally designed for diastereocontrolled construction of aldohexoses.
ElAzab
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Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan.
Taniguchi
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T
Ogasawara
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K
D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis*; D007887:Fabaceae / Q000737:chemistry; D010830:Physostigmine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D010946:Plants, Medicinal; D013237:Stereoisomerism
D002800:Cholinesterase Inhibitors; C092643:physovenine; D010830:Physostigmine