title: Morphologic and functional determinants of primordial and primary follicles in the monkey ovary.
abstract: In mammals, the mechanisms triggering initiation of follicular growth remain largely unknown. The present study constitutes an attempt to relate morphological and functional changes occuring in follicles at the time of transition from the nongrowing to the early growing stage. The population of very small follicles, including both nongrowing and early growing follicles, has been studied in fetal and adult monkey (Macaca fascicularis). Counts of these follicles and immunohistochemical analyses of their content in various intraovarian peptides led to the conclusion that initiation is probably not similar, on a quantitative as well as a qualitative point of view, in the fetal and in the adult ovary. In addition to the recently evidenced stimulatory role of the stem cell factor (SCF) in rats, activation of a nongrowing follicle might imply an arrest in the production of inhibiting factors, such as the transforming growth factor-beta2 (TGF-beta2), occurring simultaneously with the production of stimulatory factors, such as the transforming growth factor-alpha (TGFalpha).
authors.affiliation: INSERM U-407, Faculté de Médecine Lyon Sud, BP 12, 69921 Cedex, Oullins, France. gougeon@lsgrisn1.univ-lyon.fr
authors.forename: A
authors.initials: A
authors.lastname: Gougeon
authors.forename: D
authors.initials: D
authors.lastname: Busso
mesh_terms: D000328:Adult; D000818:Animals; D055430:Bone Morphogenetic Protein 15; D004815:Epidermal Growth Factor / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism; D005260:Female; D005333:Fetus; D055429:Growth Differentiation Factor 9; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins; D008252:Macaca fascicularis; D006080:Ovarian Follicle / Q000196:embryology / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D019089:Stem Cell Factor / Q000378:metabolism; D016211:Transforming Growth Factor alpha / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: C525901:BMP15 protein, human; C525904:Bmp15 protein, rat; D055430:Bone Morphogenetic Protein 15; C525897:GDF9 protein, human; C525899:Gdf9 protein, rat; D055429:Growth Differentiation Factor 9; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D018809:Proliferating Cell Nuclear Antigen; D019089:Stem Cell Factor; D016211:Transforming Growth Factor alpha; D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D019009:Proto-Oncogene Proteins c-kit