title: The involvement of neurotrophic factors in the central mechanisms of behavior in adult animals.
abstract: In the light of the similarity of the neurochemical mechanisms of behavior during ontogenesis and in adult organisms, studies were performed on the effects of antibodies to neurotrophic factors--S-100b protein, CSL lectin, and R1 lectin-on the acquisition, retention, and reproduction of habituated acoustic startle reactions and freezing behavior in adult rats. Antibodies against neurotrophic factors were found to have selective, dose-dependent effects on the types of behavior investigated. Antibodies to S-100b, CSL, and R1, at a dose of 5 microg, induced derangements in the processes of consolidation and/or retention of behavioral habits. At a dose of 2 microg, antibodies to S-100b selectively blocked the retention of long-term habituation of the startle reaction, while a dose of 0.5 microg had no such effect. Antibodies to neurotrophic factors had no effect on reproduction of acquired defensive habits.
authors.affiliation: PK Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
authors.forename: V V
authors.initials: VV
authors.lastname: Sherstnev
authors.forename: Z I
authors.initials: ZI
authors.lastname: Storozheva
authors.forename: M A
authors.initials: MA
authors.lastname: Gruden
authors.forename: A T
authors.initials: AT
authors.lastname: Proshin
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology*; D002525:Cerebellar Cortex / Q000502:physiology; D005108:Extinction, Psychological / Q000187:drug effects; D007124:Immunoenzyme Techniques; D037102:Lectins / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009414:Nerve Growth Factors / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000187:drug effects; D009418:S100 Proteins / Q000494:pharmacology
chemical_list: D037102:Lectins; D009414:Nerve Growth Factors; D009418:S100 Proteins; C059525:cerebellar soluble lectin