title: Trisomy/ tetrasomy of chromosome 8 and +i(8q) as the sole chromosome abnormality in three adult patients with myelomonocytic leukemia.
abstract: We report three cases of tetrasomy 8 associated with myeloid disease. Two patients had chronic myelomonocytic leukemia (CMMoL) and the other had acute monocytic leukemia (AML M5 FAB). Two patients had trisomy/tetrasomy chromosome 8 as the sole abnormality. The other patient with CMMoL had two normal 8 chromosomes plus one isochromosome 8q; this is the first case of long arm chromosome 8 tetrasomy without short arm 8 monosomy. This cytogenetic finding suggests the importance of the genes located in the long arms of chromosome 8.
authors.affiliation: Department of Medical Genetics, University Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: M T
authors.initials: MT
authors.lastname: Ferro
authors.forename: Y
authors.initials: Y
authors.lastname: Vázquez-Mazariego
authors.forename: S
authors.initials: S
authors.lastname: Ramiro
authors.forename: M F
authors.initials: MF
authors.lastname: Santiago
authors.forename: J M
authors.initials: JM
authors.lastname: García-Sagredo
authors.forename: R
authors.initials: R
authors.lastname: Nuñez
authors.forename: J M
authors.initials: JM
authors.lastname: Hernández
authors.forename: C
authors.initials: C
authors.lastname: San Roman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000473:pathology; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics* / Q000473:pathology; D008297:Male; D014314:Trisomy