title: Fluconazole penetration into the pancreas.
abstract: Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of fluconazole into the human pancreas and in experimental acute pancreatitis. In human pancreatic tissues, the mean fluconazole concentration was 8.19 +/- 3.38 microg/g (96% of the corresponding concentration in serum). In experimental edematous and necrotizing pancreatitis, 88 and 91% of the serum fluconazole concentration was found in the pancreas. These data show that fluconazole penetration into the pancreas is sufficient to prevent and/or treat fungal contamination in patients with pancreatic necrosis.
authors.affiliation: Department of Visceral and Transplantation Surgery, University of Bern, Switzerland.
authors.forename: S
authors.initials: S
authors.lastname: Shrikhande
authors.forename: H
authors.initials: H
authors.lastname: Friess
authors.forename: C
authors.initials: C
authors.lastname: Issenegger
authors.forename: M E
authors.initials: ME
authors.lastname: Martignoni
authors.forename: H
authors.initials: H
authors.lastname: Yong
authors.forename: B
authors.initials: B
authors.lastname: Gloor
authors.forename: R
authors.initials: R
authors.lastname: Yeates
authors.forename: J
authors.initials: J
authors.lastname: Kleeff
authors.forename: M W
authors.initials: MW
authors.lastname: Büchler
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics*; D004195:Disease Models, Animal; D015725:Fluconazole / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D010182:Pancreatic Diseases / Q000378:metabolism*; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000378:metabolism; D051381:Rats
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole