title: Botulinum toxin for oropharyngeal dysphagia: case report of flexible endoscope-guided injection.
abstract: Botulinum toxin (BT) has been used in neurology, ophthalmology, otorhinolaryngology and gastroenterology. Twenty-four patients with oropharyngeal dysphagia treated with BT injection into the cricopharyngeal muscle were reported, with good results in up to 79% of the patients. Different techniques were used to inject BT: percutaneous (guided by electromyography, computed tomography or videofluoroscopy) or direct injection during esophagoscopy (with a rigid esophagoscope). We report the first case of oropharyngeal dysphagia treated by BT injection into the cricopharyngeal muscle using a flexible scope, with clinical, radiological and manometric improvement. A reduction in the disability score 4 to 2 and sustained capacity to maintain adequate oral caloric intake were observed. The patient was also able to have the tracheotomy orifice closed and the gastrostomy tube removed after 3 months. Manometry showed a 38% reduction in the upper esophageal sphincter pressure with the presence of pharyngeal waves that were previously absent. After 1 year of follow-up, the patient was in good condition with mild dysphagia for solid foods. This is another case of complex dysphagia and relative hyperfunction of the cricopharyngeal muscle successfully treated with BT injection.
authors.affiliation: Universidade Federal de São Paulo, Division of Gastroenterology, SP, Brazil.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Brant
authors.forename: E S
authors.initials: ES
authors.lastname: Siqueira
authors.forename: A P
authors.initials: AP
authors.lastname: Ferrari
mesh_terms: D000368:Aged; D018726:Anti-Dyskinesia Agents / Q000008:administration & dosage*; D001905:Botulinum Toxins / Q000008:administration & dosage*; D004724:Endoscopy; D006801:Humans; D007273:Injections, Intramuscular / Q000379:methods; D008297:Male; D010609:Pharyngeal Muscles
chemical_list: D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins