title: Disseminated mucormycosis caused by Absidia corymbifera leading to cerebral vasculitis.
abstract: An 18-year-old woman was admitted to hospital because of subcutaneous hematoma and fever of unknown origin. Acute myeloid leukemia was diagnosed and empirical antimicrobial treatment and induction chemotherapy were started. After initial defervescence, fever relapsed 2 days after the onset of neutropenia. The CT scan of the lung was consistent with an invasive fungal infection. Treatment with amphotericin B was started and antimicrobial treatment was continued with liposomal amphotericin B because of an increase in creatinine later. The fever persisted and the patient suddenly developed progressive neurological symptoms. CT scan of the head suggested cerebral infarction and angiography of the extra- and intracranial arteries showed signs of vasculitis. Six days after the onset of neurological symptoms cerebral death was diagnosed. Autopsy revealed non-septate, irregularly branched hyphae in various histologic sections including brain. Absidia corymbifera could be isolated from lung tissue confirming the diagnosis of disseminated mucormycosis. In this case, angiographic findings suggested severe cerebral vasculitis which was in fact caused by thromboembolic dissemination of fungal hyphae. This case underlines the fact that cerebral symptoms in febrile neutropenic patients are highly indicative for fungal infections of the brain.
authors.affiliation: Medical Clinic, Hematology and Oncology, Charité University Hospital, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Eucker
authors.forename: O
authors.initials: O
authors.lastname: Sezer
authors.forename: R
authors.initials: R
authors.lastname: Lehmann
authors.forename: J R
authors.initials: JR
authors.lastname: Weber
authors.forename: B
authors.initials: B
authors.lastname: Graf
authors.forename: C
authors.initials: C
authors.lastname: Denkert
authors.forename: W
authors.initials: W
authors.lastname: Brück
authors.forename: M
authors.initials: M
authors.lastname: Schweigert
authors.forename: K
authors.initials: K
authors.lastname: Possinger
mesh_terms: D020095:Absidia / Q000302:isolation & purification; D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002533:Cerebral Angiography; D017809:Fatal Outcome; D005260:Female; D005334:Fever / Q000209:etiology; D006406:Hematoma; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009091:Mucormycosis / Q000150:complications / Q000473:pathology*; D009503:Neutropenia / Q000150:complications / Q000209:etiology; D013923:Thromboembolism / Q000150:complications / Q000473:pathology; D020293:Vasculitis, Central Nervous System / Q000209:etiology* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B