title: Regulation of human beta-defensins by gastric epithelial cells in response to infection with Helicobacter pylori or stimulation with interleukin-1.
abstract: Gastric epithelial cells in vitro and in vivo are shown to constitutively express the peptide antibiotic human beta-defensin type 1 (hBD-1). In contrast, hBD-2 expression is regulated in gastric epithelial cells and increases in response to infection with Helicobacter pylori or stimulation with the proinflammatory cytokine interleukin-1. These data suggest that hBD-2 is a component of the regulated host gastric epithelial cell response to H. pylori infection and proinflammatory mediators.
authors.affiliation: Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: O'Neil
authors.forename: S P
authors.initials: SP
authors.lastname: Cole
authors.forename: E
authors.initials: E
authors.lastname: Martin-Porter
authors.forename: M P
authors.initials: MP
authors.lastname: Housley
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Ganz
authors.forename: M F
authors.initials: MF
authors.lastname: Kagnoff
mesh_terms: D023082:Defensins; D005753:Gastric Mucosa / Q000378:metabolism*; D005786:Gene Expression Regulation; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D014407:Tumor Cells, Cultured; D023083:beta-Defensins
chemical_list: C406407:DEFB1 protein, human; D023082:Defensins; D007375:Interleukin-1; D008070:Lipopolysaccharides; D011506:Proteins; D012333:RNA, Messenger; D023083:beta-Defensins