title: CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death.
abstract: Galectin-1, an endogenous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and murine thymocytes and T cells. Galectin-1 binds to several glycoproteins on the T cell surface, including CD7. However, the T cell surface glycoprotein receptors responsible for delivering the galectin-1 death signal have not been identified. We show that CD7 is required for galectin-1-mediated death. This demonstrates a novel function for CD7 as a death trigger and identifies galectin-1/CD7 as a new biologic death signaling pair.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of California School of Medicine, Los Angeles, CA 90095, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Pace
authors.forename: H P
authors.initials: HP
authors.lastname: Hahn
authors.forename: M
authors.initials: M
authors.lastname: Pang
authors.forename: J T
authors.initials: JT
authors.lastname: Nguyen
authors.forename: L G
authors.initials: LG
authors.lastname: Baum
mesh_terms: D000276:Adjuvants, Immunologic / Q000502:physiology*; D019011:Antigens, CD7 / Q000502:physiology*; D017209:Apoptosis / Q000276:immunology*; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D016923:Cell Death / Q000276:immunology; D002460:Cell Line; D037483:Galectin 1; D006388:Hemagglutinins / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D007424:Intracellular Fluid / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D000276:Adjuvants, Immunologic; D019011:Antigens, CD7; D037483:Galectin 1; D006388:Hemagglutinins; D002118:Calcium