High prevalence of factor V Leiden mutation in mothers of premature neonates.
The prevalence of the Leiden mutation was tested in 50 mothers of premature infants and in 56 mothers of intrauterine-growth-retarded neonates. The prevalence of the Leiden mutation was 7.2% in the mothers of growth-retarded neonates and 18% in the group of mothers of premature infants, the latter being significantly higher than the 6.3% prevalence of this mutation in healthy Hungarian subjects (p < 0.01). In spite of the relatively small number of mothers examined, the unexpected finding may call attention to a hitherto unknown relationship.
Erhardt
E
E
Department of Paediatrics, University Medical School of Pécs, Hungary. erhardte@apacs.pote.hu
Stankovics
J
J
Molnár
D
D
Adamovich
K
K
Melegh
B
B
D004252:DNA Mutational Analysis; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005165:Factor V / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics; D006801:Humans; D006814:Hungary; D007231:Infant, Newborn; D007234:Infant, Premature; D009154:Mutation; D016133:Polymerase Chain Reaction; D011247:Pregnancy
C095381:factor V Leiden; D005165:Factor V; C052155:endodeoxyribonuclease MnlI; D015252:Deoxyribonucleases, Type II Site-Specific