title: Chronic toxicity of rare-earth elements on human beings: implications of blood biochemical indices in REE-high regions, South Jiangxi.
abstract: Blood analyses for rare-earth element (REE)-high background regions in South Jiangxi show that the population averages of many of the biochemical indices deviate markedly from normal values in the normal region. These deviations are thought to be caused by prolonged intake of REE through food chains in view of that the toxicity of other harmful metals such as Pb and Cd can be neglected because of their insignificant amounts in the environment. In comparison with the normal region, blood biochemical indices abnormal in the REE-high regions are manifested as low total serum protein (TSP), albumin, beta-globulin, glutamic pyruvic transitanase, serium triglycerides, and immunoglobulin, but high cholesterol. These deviations may be related to the REE concentration and composition of food chains, and are sex dependent. Certain blood indices (such as TSP) of different age groups in the LREE-high region indicate that the influence of REE on males is a one-way irreversible process, whereas females show a strong ability of restoration.
authors.affiliation: State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Feng
authors.forename: W
authors.initials: W
authors.lastname: Zhu
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Xu
authors.forename: P
authors.initials: P
authors.lastname: Shao
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.forename: W
authors.initials: W
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Gu
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000418:Albumins / Q000378:metabolism; D002104:Cadmium / Q000633:toxicity; D002681:China; D002784:Cholesterol / Q000097:blood; D005260:Female; D005506:Food Contamination; D005914:Globins / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007854:Lead / Q000633:toxicity; D008297:Male; D019216:Metals, Heavy / Q000633:toxicity*; D008875:Middle Aged; D015233:Models, Statistical; D011506:Proteins / Q000378:metabolism; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D000418:Albumins; D007136:Immunoglobulins; D019216:Metals, Heavy; D011506:Proteins; D014280:Triglycerides; D002104:Cadmium; D007854:Lead; D005914:Globins; D002784:Cholesterol; D000410:Alanine Transaminase