title: Simultaneous presence of t(2;8)(p12;q24) and t(14;18)(q32;q21) in a B-cell lymphoproliferative disorder with features suggestive of an aggressive variant of splenic marginal-zone lymphoma.
abstract: We report a case of an aggressive variant of splenic marginal-zone lymphona (SMZL) with circulating villous lymphocytes. The karyotype of all examined cells had multiple structural and numerical abnormalities, including two lymphoma characteristic translocations, t(2;8)(p12;q24) and t(14;18)(q32;q21). Based on a literature review of cytogenetic aberrations of splenic lymphoma with villous lymphocytes (SLVL) and SMZL, this is apparently the first documentation of these two translocations in a case of SMZL, and could reflect the heterogeneity of the disorder.
authors.affiliation: Department of Pediatrics, St. Louis University School of Medicine, St. Louis, MO, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Batanian
authors.forename: C H
authors.initials: CH
authors.lastname: Dunphy
authors.forename: J M
authors.initials: JM
authors.lastname: Richart
authors.forename: P J
authors.initials: PJ
authors.lastname: Petruska
authors.forename: S L
authors.initials: SL
authors.lastname: Perkins
mesh_terms: D000368:Aged; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology / Q000473:pathology; D013160:Splenic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014178:Translocation, Genetic