An image-based 3D planning environment for hemicricolaryngectomy and reconstruction by tracheal autotransplantation.
OBJECTIVE
A new conservation method for unilateral glottal cancer with significant subglottal extension consists of a hemicricolaryngectomy and subsequent reconstruction of the laryngeal defect with a transferable patch of revascularized cervical trachea. In order to restore the three crucial functions of the larynx - airway patency, speech, and swallowing--the reconstructed larynx should resemble a situation with one paralyzed and one intact vocal fold at the glottal level. We hypothesize that this result can be achieved when the tracheal patch meets a typical surgical constraint--the so-called paramedian position at the glottal level - and when the patch is rigidly applied. This hypothesis was tested by developing and using an image-based planning system in a number of situations.


METHODS
An image-based surgery simulator was developed according to the working hypothesis. To validate the transfer from planning towards actual surgery, a cadaver study was set up. Based on a patient case-study, the sufficiency of the hypothesis for obtaining good functional results was evaluated. Finally, post-operative images of patients who were doing well after being operated without pre-operative planning were compared with retrospective planning to check the necessity of the hypothesis in obtaining good functionality of the neolarynx.


RESULTS
We were able to design an efficient surgery simulator. The transfer from planning towards actual surgery is accurate, and satisfactory functional results were obtained from the patient case-study. The results from the retrospective planning showed that the hypothesis is not necessary to obtain good functional results, and that the smallest possible resection is preferred from the oncological point of view.


CONCLUSIONS
The working hypothesis is sufficient for good functional results, but is unnecessary and often undesirable from an oncological point of view. Important lessons are drawn concerning our long-term goal of pre-operative determination of the shape and position of a tracheal patch suitable for optimizing the (neo-) laryngeal functions.
Schutyser
F
F
Medical Image Computing (Radiology -ESAT/PSI), and Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium. filip.schutyser@uz.kuleuven.ac.be
Poorten
V V
VV
Van Cleynenbreugel
J
J
Delaere
P
P
Suetens
P
P
D002102:Cadaver; D003198:Computer Simulation; D003413:Cricoid Cartilage / Q000601:surgery*; D003679:Deglutition / Q000502:physiology; D005931:Glottis / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007822:Laryngeal Neoplasms / Q000601:surgery; D007825:Laryngectomy / Q000379:methods*; D007830:Larynx / Q000503:physiopathology; D010347:Patient Care Planning; D017060:Patient Satisfaction; D015203:Reproducibility of Results; D012119:Respiration; D012189:Retrospective Studies; D013060:Speech / Q000502:physiology; D013813:Therapy, Computer-Assisted; D014057:Tomography, X-Ray Computed; D014132:Trachea / Q000637:transplantation*; D014182:Transplantation, Autologous; D016896:Treatment Outcome