title: A comparative evaluation of tretinoin gel microsphere, 0.1%, versus tretinoin cream, 0.025%, in reducing facial shine.
abstract: Tretinoin gel microsphere, 0.1%, is a highly effective anti-acne medication formulated with sponge-like microspheres encapsulating the active ingredient, tretinoin. In addition to minimizing cutaneous irritation, this system may also reduce facial shine. This single-center, double-blind, half-face study evaluated the potential of tretinoin gel microsphere, 0.1%, to reduce the appearance of facial shine compared to tretinoin cream, 0.025%. Thirty-five subjects (ages 12 to 24 years) with moderate acne vulgaris and moderate facial oiliness, were evaluated after 4 consecutive days of product use. On sides treated with tretinoin gel microsphere, 0.1%, investigators found significantly reduced facial shine at 3 and 6 hours posttreatment. Subjects' self-evaluations revealed a significant reduction in facial shine at 3 hours posttreatment. Photographic analyses showed reductions in facial shine for both treatments, but decreases were greater on tretinoin gel microsphere, 0.1%-treated sides. Both therapies were well tolerated, and no adverse events occurred. Tretinoin gel microsphere, 0.1%, has the added benefit of reducing the appearance of facial shine, which is a frequent concern in acne patients.
authors.affiliation: Johnson & Johnson Consumer Products Worldwide, Skillman, NJ 08558-9418, USA.
authors.forename: J
authors.initials: J
authors.lastname: Nyirady
authors.forename: M
authors.initials: M
authors.lastname: Nighland
authors.forename: G
authors.initials: G
authors.lastname: Payonk
authors.forename: J
authors.initials: J
authors.lastname: Pote
authors.forename: S
authors.initials: S
authors.lastname: Phillips
authors.forename: R
authors.initials: R
authors.lastname: Grossman
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000378:metabolism; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D004311:Double-Blind Method; D005145:Face; D005260:Female; D005782:Gels; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage*; D008055:Lipids / Q000096:biosynthesis; D008297:Male; D009824:Ointments; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D005782:Gels; D007641:Keratolytic Agents; D008055:Lipids; D009824:Ointments; D014212:Tretinoin