title: The relationship between Helicobacter pylori IgG antibody and autologous serum test in chronic urticaria.
abstract: BACKGROUND
  In chronic urticaria, suspicious factors are Helicobacter pylori (HP) infection and autoimmunity, as well as other etiologic agents. Autologous serum injection is the first step to identify autoimmune urticaria. Our study was performed to determine the prevalence of HP infection in patients with chronic urticaria, and to evaluate the results of autologous serum testing in chronic urticaria patients who had HP antibodies.
  
  
  METHODS
  HP immunoglobulin G (IgG) antibody was defined by an immunochromatographic method in 61 chronic urticaria patients and 15 healthy persons. Autologous serum testing was performed in 32 chronic urticaria patients.
  
  
  RESULTS
  HP IgG antibody was found to be positive in 41% of chronic urticaria patients and 26% of healthy controls (chi2= 7.82, P= 0.005). Autologous serum testing was positive in 40% of chronic urticaria patients who had HP IgG antibody. This ratio was 14.3% in chronic urticaria patients who did not have HP IgG antibody (chi2 = 9.23, P= 0.002).
  
  
  CONCLUSIONS
  In this study, autologous serum testing was found to highly positive in chronic urticaria patients with HP IgG antibody, but the relationship between autoimmunity and HP infection requires further investigations.
authors.affiliation: Department of Dermatology, Trakya University Medical Faculty, Edirne, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Hizal
authors.forename: B
authors.initials: B
authors.lastname: Tüzün
authors.forename: R
authors.initials: R
authors.lastname: Wolf
authors.forename: Y
authors.initials: Y
authors.lastname: Tüzün
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D001327:Autoimmune Diseases / Q000209:etiology*; D016022:Case-Control Studies; D002908:Chronic Disease; D005767:Gastrointestinal Diseases / Q000150:complications / Q000453:epidemiology*; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D015995:Prevalence; D014421:Turkey / Q000453:epidemiology; D014581:Urticaria / Q000209:etiology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G