Carbohydrate-deficient transferrin and sialidase levels in coronary heart disease.
Transferrin is a N-glycosylated glycoprotein and plays an important role in iron transport from sites of absorption and storage to sites of utilization. The main component of normal serum transferrin contains two biantennary glycans, each consisting of 2 mol of sialic acid (Tetrasialo transferrin). Normal serum also contains small amounts of tri- and disialotransferrin. We have undertaken this study to investigate the levels of serum carbohydrate-deficient transferrin (Desialotransferrin) and sialidase levels in patients with coronary heart disease. In patient group, serum desialotransferrin and sialidase levels were found to be significantly higher than control group (p < 0.01 and p < 0.001, respectively). We conclude that increased activity of sialidase may be responsible for increased desialotransferrin in patients with coronary heart disease. Serum desialotransferrin levels may be useful critaria to diagnosis and pathogenesis of coronary heart disease.
Sönmez
H
H
Department of Biochemistry, Istanbul, Turkey.
Oztürk
Z G
ZG
Ulutin
T
T
Domaniç
N
N
Kökoğlu
E
E
D000328:Adult; D000368:Aged; D001212:Asialoglycoproteins / Q000737:chemistry / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D009439:Neuraminidase / Q000097:blood*; D014168:Transferrin / Q000737:chemistry / Q000378:metabolism*
D001212:Asialoglycoproteins; D015415:Biomarkers; D008055:Lipids; D014168:Transferrin; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid