Endometrial cell death during early pregnancy in the rat.
In a study of early pregnancy in the rat, a high proportion of morphologically apoptotic, TUNEL and P2X7 positive cells were found to be present in the luminal epithelium and stroma prior to implantation. At the time of implantation on Day 6, apoptosis as measured by these indicators was reduced up to 4-fold in the non-implantation uterine epithelium but was markedly increased adjacent to the implanting blastocyst. It is proposed that apoptotic cell death is an important regulatory factor involved in uterine remodelling prior to and during implantation.
Tassell
W
W
Institute for Biomedical Research and Department of Anatomy and Histology, The University of Sydney, NSW, Australia.
Slater
M
M
Barden
J A
JA
Murphy
C R
CR
D000818:Animals; D017209:Apoptosis; D002452:Cell Count; D003627:Data Interpretation, Statistical; D003856:Deoxyuracil Nucleotides / Q000378:metabolism; D010064:Embryo Implantation; D004717:Endometrium / Q000166:cytology / Q000378:metabolism*; D005260:Female; D020287:In Situ Nick-End Labeling; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D017208:Rats, Wistar; D018048:Receptors, Purinergic P2 / Q000096:biosynthesis*; D058486:Receptors, Purinergic P2X7; D013997:Time Factors
D003856:Deoxyuracil Nucleotides; C546470:P2rx7 protein, rat; D018048:Receptors, Purinergic P2; D058486:Receptors, Purinergic P2X7; C027078:deoxyuridine triphosphate