[Macrolides and Pseudomonas aeruginosa infection].
Several unique effects of subinhibitory concentrations of C14 and C15 macrolides on Pseudomonas aeruginosa infection are described in vitro: P. aeruginosa virulence factors inhibition, bacterial biofilm disruption, P. glycoprotein expression upregulation, anti-inflammatory and immunoregulatory effects. Clinical trials in vivo are warranted to assess the potential usefulness of macrolides for treatment of chronic infections caused by P. aeruginosa.
Guillot
M
M
Centre hospitalier général, Lisieux, France.
Eckart
P
P
Desrosières
H
H
Brouard
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D018942:Macrolides; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*; D014774:Virulence
D000900:Anti-Bacterial Agents; D018942:Macrolides