[Hemolytic anemia in a newborn after maternal treatment with nitrofurantoin at the end of pregnancy].
Drug administration during the last trimester of pregnancy may have adverse effects for the newborn.


METHODS
A hemolytic anemia occurred during the first hours of life in a full-term neonate whose mother had taken nitrofurantoin during the last month of pregnancy.


CONCLUSIONS
The immature enzymatic systems of the neonate are exposed to this adverse effect and justify the recommendation not to prescribe nitrofurantoin at the end of pregnancy.
Bruel
H
H
Service de médecine néonatale, hôpital Flaubert, Le Havre, France.
Guillemant
V
V
Saladin-Thiron
C
C
Chabrolle
J P
JP
Lahary
A
A
Poinsot
J
J
D000328:Adult; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000009:adverse effects*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D011263:Pregnancy Trimester, Third; D014552:Urinary Tract Infections / Q000188:drug therapy
D000892:Anti-Infective Agents, Urinary; D009582:Nitrofurantoin