title: Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1.
abstract: Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicate in the human thymus in vivo. In this model, however, the presence of one virus appears not to modify the replication or cytopathicity of the other.
authors.affiliation: Unit of Human Virology, Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Gobbi
authors.forename: C A
authors.initials: CA
authors.lastname: Stoddart
authors.forename: G
authors.initials: G
authors.lastname: Locatelli
authors.forename: F
authors.initials: F
authors.lastname: Santoro
authors.forename: C
authors.initials: C
authors.lastname: Bare
authors.forename: V
authors.initials: V
authors.lastname: Linquist-Stepps
authors.forename: M E
authors.initials: ME
authors.lastname: Moreno
authors.forename: N W
authors.initials: NW
authors.lastname: Abbey
authors.forename: B G
authors.initials: BG
authors.lastname: Herndier
authors.forename: M S
authors.initials: MS
authors.lastname: Malnati
authors.forename: J M
authors.initials: JM
authors.lastname: McCune
authors.forename: P
authors.initials: P
authors.lastname: Lusso
mesh_terms: D000818:Animals; D003588:Cytopathogenic Effect, Viral; D004268:DNA-Binding Proteins / Q000032:analysis; D005434:Flow Cytometry; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006566:Herpesviridae Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D016513:Mice, SCID; D013601:T-Lymphocytes / Q000821:virology; D014764:Viral Proteins / Q000032:analysis; D014779:Virus Replication
chemical_list: D004268:DNA-Binding Proteins; D016655:HIV Core Protein p24; D014764:Viral Proteins; C081690:p41 protein, Human herpesvirus 6