Sodium homeostasis in transplanted rats with a spontaneously hypertensive rat kidney.
Recipients of a kidney from spontaneously hypertensive rats (SHR) but not from normotensive Wistar-Kyoto rats (WKY) develop posttransplantation hypertension. To investigate whether renal sodium retention precedes the development of posttransplantation hypertension in recipients of an SHR kidney on a standard sodium diet (0.6% NaCl), we transplanted SHR and WKY kidneys to SHR x WKY F1 hybrids, measured daily sodium balances during the first 12 days after removal of both native kidneys, and recorded mean arterial pressure (MAP) after 8 wk. Recipients of an SHR kidney (n = 12) retained more sodium than recipients of a WKY kidney (n = 12) (7.3 +/- 10 vs. 4.0 +/- 0.7 mmol, P < 0.05). MAP was 144 +/- 6 mmHg in recipients of an SHR kidney and 106 +/- 5 mmHg in recipients of a WKY kidney (P < 0.01). Modest sodium restriction (0.2% NaCl) in a further group of recipients of an SHR kidney (n = 10) did not prevent posttransplantation hypertension (MAP, 142 +/- 4 mmHg). Urinary endothelin and urodilatin excretion rates were similar in recipients of an SHR and a WKY kidney. Transient excess sodium retention after renal transplantation may contribute to posttransplantation hypertension in recipients of an SHR kidney.
Frey
B A
BA
Department of Physiology, Ernst Moritz Arndt University Greifswald, D-17495 Karlsburg, Germany.
Grisk
O
O
Bandelow
N
N
Wussow
S
S
Bie
P
P
Rettig
R
R
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000652:urine; D004039:Diet, Sodium-Restricted; D016232:Endothelins / Q000652:urine; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D006977:Hypertension, Renal / Q000178:diet therapy / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D009392:Nephrectomy; D010446:Peptide Fragments / Q000652:urine; D011183:Postoperative Complications / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012964:Sodium / Q000097:blood / Q000652:urine*; D017673:Sodium Chloride, Dietary / Q000494:pharmacology
D016232:Endothelins; D010446:Peptide Fragments; D017673:Sodium Chloride, Dietary; C056452:Ularitide; D009320:Atrial Natriuretic Factor; D012964:Sodium