Compressed xanthan and karaya gum matrices: hydration, erosion and drug release mechanisms.
Directly compressed matrices were produced containing either xanthan gum or karaya gum as a release-controlling agent. These swellable hydrophilic natural gums were used to control the release of varying proportions of two model drugs, caffeine and diclofenac sodium, which have different solubilities in aqueous medium. Gum erosion, hydration and drug release studies were carried out using a dissolution apparatus (basket method) at two agitation speeds. Xanthan gum displayed a high degree of swelling due to water uptake and a small degree of erosion due to polymer relaxation. Neither agitation speed nor drug solubility had any significant effect on water uptake, but matrices with the lower proportion of gum produced a lesser degree of hydration. In contrast, karaya gum displayed a much lower hydration capacity and a higher rate of erosion, both markedly affected by agitation speed. Drug release from xanthan and karaya gum matrices depended on agitation speed, solubility and proportion of drug. Both xanthan and karaya gums produced near zero order drug release with the erosion mechanism playing a dominant role, especially in karaya gum matrices.
Munday
D L
DL
School of Pharmacy, The Robert Gordon University, Schoolhill, AB101FR, Aberdeen, UK. pasdlm@rgu.ac.uk
Cox
P J
PJ
D002110:Caffeine / Q000008:administration & dosage; D004008:Diclofenac / Q000008:administration & dosage; D004337:Drug Carriers; D007618:Karaya Gum / Q000008:administration & dosage*; D007700:Kinetics; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*; D012995:Solubility
D004337:Drug Carriers; D011135:Polysaccharides, Bacterial; D004008:Diclofenac; D002110:Caffeine; D007618:Karaya Gum; C002563:xanthan gum