[A study of the pathogenesis of tonsillar focal infection--transplantation of human tonsillar lymphocytes and human skin into SCID mice].
Pustulosis palmaris et plantaris (PPP) has been considered as one of the typical tonsillar focal infections, based on the marked clinical improvement of the skin lesions after tonsillectomy. In early-stage of PPP, it has been reported that lymphocytes, predominantly CD4-positive cells, infiltrate the palmar and plantar skin. However, the origin and mechanism of infiltration by these lymphocytes is not clear and there are very few reports on whether tonsillar cells react directly with the skin, possibly due to the difficulty of establishing adequate animal models. In this study, we established an experimental animal model of mice with severe combined immunodeficiency (SCID) and observed the reactions of the tonsillar lymphocytes (TL) or peripheral blood lymphocytes (PBL) of patients with PPP to their own plantar skin by transplanting the lymphocytes and skin of the patient into the mice. The results revealed that TL infiltrated the skin to a significantly greater extent than PBL. Most of these lymphocytes were T lymphocytes, and no B lymphocytes were detected in the transplanted skin. Strong expression of LFA-1 and ICAM-1 was observed in the skin after the TL transplantation. These results suggest that TL have a strong affinity for the skin in PPP, and that the adhesion molecules may play an important role in the infiltration by lymphocytes of the skin.
Yamamoto
Y
Y
Department of Otorhinolaryngology, Wakayama Medical College.
Kuki
K
K
Hayashi
Y
Y
Yamanaka
N
N
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000637:transplantation; D017690:Cell Transplantation; D005121:Extremities; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism / Q000502:physiology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism / Q000502:physiology; D051379:Mice; D016513:Mice, SCID; D014066:Palatine Tonsil / Q000166:cytology*; D011565:Psoriasis / Q000209:etiology*; D012867:Skin / Q000276:immunology / Q000378:metabolism; D016038:Skin Transplantation
D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1