title: [Pronounced bilateral mammary hypertrophy as a rare manifestation of acute lymphatic leukemia].
abstract: A 33-year-old patient, hitherto healthy, has been admitted for clarification of bilateral mammary hypertrophy. In the course of the usual routine examination a lump of the size of a cherry was identified in the right breast. Within 6 weeks both breasts had become tight and grown symmetrically to three times their original size. A provisionary diagnosis of high malignant non-hodgkin lymphoma was made by multiple high speed needle biopsies and was later confirmed by a surgical tissue specimen of the right breast. For further classification a bone-marrow biopsy was taken from the pelvic bone and an immature acute lymphoblastic leukemia (ALL), known as preB1-ALL, diagnosed. Sonographic examination, computer tomography of the thorax and mammographical findings, as well as symptoms, outcome and differential diagnosis of a proliferative lymphatic disease with first manifestation in both breasts are presented and discussed.
authors.affiliation: Frauenklinik, Klinikum Osnabrück GmbH.
authors.forename: M
authors.initials: M
authors.lastname: Sindel
authors.forename: S
authors.initials: S
authors.lastname: Böhmer
authors.forename: W
authors.initials: W
authors.lastname: Rhein
authors.forename: J
authors.initials: J
authors.lastname: Hartlapp
authors.forename: R H
authors.initials: RH
authors.lastname: Krech
authors.forename: K
authors.initials: K
authors.lastname: Goeschen
mesh_terms: D000328:Adult; D001706:Biopsy; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis; D002051:Burkitt Lymphoma / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006984:Hypertrophy / Q000209:etiology; D016217:Ultrasonography, Mammary