L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas.
L-MYC and GSTM1 genotypes were analysed in glioma patients (GP) and healthy donors (HD). None of these genes appeared to influence the risk of this disease, however both polymorphisms correlated with unfavourable clinical parameters of gliomas. In particular, S allele of the L-MYC was overrepresented in the relapsed patients (P < 0.05), and GSTM1-null genotype was associated with the advanced tumour grade (P < 0.05). Patients, but not donors, demonstrated frequent combination of SS L-MYC homozygosity with GSTM1(-) variant (P < 0.01 ), as well as a correlation between LL L-MYC homozygosity and GSTM1 (+) genotype (P < 0.05).
Kondratieva
T V
TV
Dept. of Pediatric Surgery, L.A. Polenov Neurosurgery Institute, St. Petersburg, Russia.
Imyanitov
E N
EN
Togo
A V
AV
Zaitseva
O A
OA
Yatsuk
O S
OS
Romanenko
S M
SM
Bersnev
V P
VP
Hanson
K P
KP
D000483:Alleles; D001932:Brain Neoplasms / Q000201:enzymology / Q000235:genetics*; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis; D005787:Gene Frequency; D016259:Genes, myc / Q000235:genetics*; D005838:Genotype; D005910:Glioma / Q000201:enzymology / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D017931:DNA Primers; D004273:DNA, Neoplasm; D005982:Glutathione Transferase