[Ways of antioxidative prevention of complications in immediate postoperative period in children with nephroblastoma].
The parameters of the activity of the antioxidative system (AOS) were studied in 85 patients aged 1 to 14 years who had nephroblastoma in the immediate postoperative period. They were compared with those in healthy children. To prevent AOS failure, Group 1 patients with nephroblastoma received ascorbic acid (AA) in a dose of 15 mg. Group 2 patients took a larger dose (25-30 mg) in combination with alpha-tocopherol. It was ascertained that the small dose of AA did not prevent AOS failure in the postoperative period while its larger doses prevented significant manifestations of antioxidative protective deficit, by reducing the incidence and severity of postoperative trophic complications.
Ordukhanian
Z S
ZS
Gorozhanskaia
E G
EG
Saltanov
A I
AI
D000293:Adolescent; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000601:surgery*; D015227:Lipid Peroxidation / Q000187:drug effects; D009392:Nephrectomy / Q000009:adverse effects*; D011183:Postoperative Complications / Q000378:metabolism / Q000517:prevention & control*; D011184:Postoperative Period; D011379:Prognosis; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*; D009396:Wilms Tumor / Q000601:surgery*
D000975:Antioxidants; D014810:Vitamin E; D001205:Ascorbic Acid