Absolute stereochemistry of amphidinolides G and H.
[structure: see text] Absolute stereochemistry of amphidinolides G (1) and H (2), potent cytotoxic 27- and 26-membered macrolides, respectively, isolated from a marine dinoflagellate Amphidinium sp., was determined by X-ray diffraction analysis, synthesis of a degradation product (3) of 2, and interconversion between 1 and 2.
Kobayashi
J
J
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
Shimbo
K
K
Sato
M
M
Shiro
M
M
Tsuda
M
M
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000737:chemistry*; D008387:Marine Toxins / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D014961:X-Ray Diffraction; D000097442:Amphidinolides
D018942:Macrolides; D008387:Marine Toxins; C414663:amphidinolide G; D000097442:Amphidinolides; C414664:amphidinolide H