[In vitro effects of L-carnitine on the inhibition of sperm mobility induced by FANS].
OBJECTIVE
We wanted to study the function of some substances present in the seminal fluid (PG and L. Carnitine), which, with different mechanisms, affected Spermatozoa motility, and to study the effect of other substances (F.A.N.S.), known also for their action on P.G.


METHODS
Ten samples of seminal fluid from healthy subjects were studied according to the indications of the World Health Organization (1992).


RESULTS
All the F.A.N.S. used (Cinnoxicam, Salicylic Acetyl Acid) had an inhibitory effect on motility, as did L. Carnitine at high doses. We thought it interesting to observe if L. Carnitine added to the seminal fluid before F.A.N.S. blocked their effects.


CONCLUSIONS
The pre-treatment with L. Carnitine had an "in vitro" buffering effect on F.A.N.S.
Mangano
N G
NG
Cattedra di Patologia Generale, Facoltà di Scienze, Università di Catania, Italia.
Sabella
P
P
Mangano
A
A
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000037:antagonists & inhibitors*; D001241:Aspirin / Q000037:antagonists & inhibitors*; D002331:Carnitine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D013081:Sperm Motility / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C057291:piroxicam cinnamate; D001241:Aspirin; D002331:Carnitine