title: Correlates of symptom dimensions in schizophrenia obtained with the Spanish version of the Manchester scale.
abstract: In the last decade, a significant number of studies have been published which suggest a multifactorial psychopathological structure in schizophrenia. Seventy-eight acute and chronic schizophrenic patients diagnosed in accordance with DSM-III-R criteria were studied with the Manchester Scale, Premorbid Adjustment Scale, Family History-RDC Interview, Digit Span, Mini-Mental State and computerized tomography (CT). A factorial analysis of the symptoms as recorded with the Spanish version of the Manchester Scale was carried out. Three factors ('positive', 'negative' and 'disorganization') accounted for 79% of the total variance. Poor premorbid adjustment was associated with high scores for the 'positive' dimension. The 'disorganization' dimension was significantly associated with lower scores in the Mini-Mental and attention test than the rest. However, CT did not differentiate between these symptom dimensions. This study of a sample of mostly outpatients corroborates the hypothesis of three clinical dimensions in schizophrenia.
authors.affiliation: Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Spain. Rafael.Tabares@uv.es
authors.forename: R
authors.initials: R
authors.lastname: Tabarés
authors.forename: J
authors.initials: J
authors.lastname: Sanjuán
authors.forename: M
authors.initials: M
authors.lastname: Gómez-Beneyto
authors.forename: C
authors.initials: C
authors.lastname: Leal
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000706:statistics & numerical data; D012559:Schizophrenia / Q000175:diagnosis*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed