Paeonilide, a novel anti-PAF-active monoterpenoid-derived metabolite from Paeonia delavayi.
A novel monoterpenoid-derived metabolite, paeonilide, was isolated from the roots of Paeonia delavayi. Its structure was established by a combination of spectroscopic and X-ray crystallographic analyses. It showed an anti-PAF effect with an IC50 value of ca. 8 microg/ml.
Liu
J K
JK
Department of Phytochemistry, Kunming Institute of Botany, The Chinese Academy of Sciences, P.R. China. jkl@public.km.yn.cn
Ma
Y B
YB
Wu
D G
DG
Lu
Y
Y
Shen
Z Q
ZQ
Zheng
Q T
QT
Chen
Z H
ZH
D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry* / Q000378:metabolism; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification; D013729:Terpenes / Q000737:chemistry* / Q000145:classification / Q000302:isolation & purification
D004365:Drugs, Chinese Herbal; D010972:Platelet Activating Factor; D010975:Platelet Aggregation Inhibitors; D013729:Terpenes; C416702:paeonilide