title: Three-dimensional intravascular ultrasonic volumetric quantification of stent recoil and neointimal formation of two new generation tubular stents.
abstract: Currently, several different designs of coronary stents are available. However, only a few of the new generation stents have been investigated in large randomized trials. Mechanical behavior of first-generation stents (Palmaz-Schatz, Gianturco-Roubin) may not be applied to the new designs. We investigated the chronic mechanical behavior (recoil) of 2 stents recently approved by the Food and Drug Administration (MULTILINK and NIR). Forty-eight patients with single-stent implantation (23 MULTILINK and 25 NIR) were assessed by means of volumetric 3-dimensional intravascular ultrasound analysis after the procedure and at 6-month follow-up. In addition, volumetric assessment of neointimal formation was performed. No significant chronic stent recoil was detected in both groups (delta MULTILINK stent volume: +5.6+/-41 mm3 [p = NS] and delta NIR stent volume + 2.1+/-26 mm3 [p = NS]). A similar degree of neointimal formation at 6 months was observed between the 2 stents (MULTILINK 46+/-31.9 mm3 vs NIR 39.9+/-27.6 mm3, p = NS). In conclusion, these 2 second-generation tubular stents did not show chronic recoil and appeared to promote similar proliferative response after implantation in human coronary arteries.
authors.affiliation: Thoraxcenter, Dijkzigt University Hospital, Rotterdam, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: Costa
authors.forename: M
authors.initials: M
authors.lastname: Sabate
authors.forename: I P
authors.initials: IP
authors.lastname: Kay
authors.forename: P J
authors.initials: PJ
authors.lastname: de Feyter
authors.forename: K
authors.initials: K
authors.lastname: Kozuma
authors.forename: P
authors.initials: P
authors.lastname: Serrano
authors.forename: V
authors.initials: V
authors.lastname: de Valk
authors.forename: M
authors.initials: M
authors.lastname: Albertal
authors.forename: J M
authors.initials: JM
authors.lastname: Ligthart
authors.forename: C
authors.initials: C
authors.lastname: Disco
authors.forename: D P
authors.initials: DP
authors.lastname: Foley
authors.forename: P W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D002455:Cell Division; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents; D017539:Tunica Intima / Q000166:cytology* / Q000000981:diagnostic imaging*; D014463:Ultrasonography