Severe combined immunodeficiency in a Malaysian child.
A 3-month-old Malay male infant presented with multiple infections (candidiasis, Pseudomonas aeruginosa, Cytomegalovirus), persistent pneumonia, intractable diarrhoea and failure to thrive. There was lymphopaenia affecting both T and B subsets. He developed Graft versus Host disease weeks following transfusion with non irradiated blood. In spite of aggressive microbicidal and supportive therapy including regular immunoglobulin infusions, the child succumbed to infection before a bone marrow transplant could be instituted.
Noh
L M
LM
Dept of Immunology, School of Medicine, Universiti Sains Malaysia, Kelantan.
Amir
H L
HL
Hung
L C
LC
Zulkifli
I
I
Nasuruddin
B A
BA
D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D016511:Severe Combined Immunodeficiency / Q000150:complications / Q000276:immunology*