title: The plasma membrane proton-translocating ATPase.
abstract: Living cells require membranes and membrane transporters for the maintenance of life. After decades of biochemical scrutiny, the structures and molecular mechanisms by which membrane transporters catalyze transmembrane solute movements are beginning to be understood. The plasma membrane proton-translocating adenosine triphosphatase (ATPase) is an archetype of the P-type ATPase family of membrane transporters, which are important in a wide variety of cellular processes. The H+-ATPase has been crystallized and its structure determined to a resolution of 8 angstrom in the membrane plane. When considered together with the large body of biochemical information that has been accumulated for this transporter, and for enzymes in general, this new structural information is providing tantalizing insights regarding the molecular mechanism of active ion transport catalyzed by this enzyme.
authors.affiliation: Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA. gas@med.unc.edu
authors.forename: G A
authors.initials: GA
authors.lastname: Scarborough
mesh_terms: D002462:Cell Membrane / Q000201:enzymology* / Q000378:metabolism; D003460:Crystallization; D018360:Crystallography, X-Ray; D017136:Ion Transport; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D008958:Models, Molecular; D009492:Neurospora crassa / Q000201:enzymology; D011487:Protein Conformation; D006180:Proton-Translocating ATPases / Q000737:chemistry* / Q000378:metabolism* / Q000648:ultrastructure; D011522:Protons; D013329:Structure-Activity Relationship
chemical_list: D008565:Membrane Proteins; D011522:Protons; D006180:Proton-Translocating ATPases