title: Absolute stereochemistry of amphidinolides G and H.
abstract: [structure: see text] Absolute stereochemistry of amphidinolides G (1) and H (2), potent cytotoxic 27- and 26-membered macrolides, respectively, isolated from a marine dinoflagellate Amphidinium sp., was determined by X-ray diffraction analysis, synthesis of a degradation product (3) of 2, and interconversion between 1 and 2.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. jkobay@pharm.hokudai.ac.jp
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Shimbo
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Shiro
authors.forename: M
authors.initials: M
authors.lastname: Tsuda
mesh_terms: D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000737:chemistry*; D008387:Marine Toxins / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D014961:X-Ray Diffraction; D000097442:Amphidinolides
chemical_list: D018942:Macrolides; D008387:Marine Toxins; C414663:amphidinolide G; D000097442:Amphidinolides; C414664:amphidinolide H