title: Intracranial vertebrobasilar stenosis: angioplasty and follow-up.
abstract: OBJECTIVE
  When medication fails to improve symptoms of atherosclerotic stenosis of the intracranial vertebral and basilar arteries, percutaneous transluminal angioplasty (PTA) is considered. However, because investigators disagree on the usefulness of this procedure, we conducted a retrospective study to evaluate the indications, efficacy, and safety of PTA.
  
  
  METHODS
  Twenty patients underwent PTA of the vertebral (n = 14) or basilar (n = 6) artery, 18 for neurologic signs and symptoms of arterial stenosis that recurred or progressed despite pharmacotherapy and two prophylactically. Neurologic examinations were performed before and after the procedure and arterial patency was evaluated at follow-up by digital subtraction angiography and/or MR angiography. Imaging follow-up was available for 14 (70%) of the 20 patients, neurologic follow-up for 15 (75%).
  
  
  RESULTS
  The stenosis was successfully dilated in all patients, and on follow-up neuroradiologic examinations, vessel patency could be seen in 12 (86%) of 14 patients. Only one (7%) of 15 patients who returned for a follow-up neurologic examination had new symptoms (caused by occlusion of the vertebral artery 4 months after the procedure). One patient had a reversible neurologic deficit and one had hemiparesis after PTA. No patient died as a result of PTA.
  
  
  CONCLUSIONS
  In our study, PTA of intracranial vertebrobasilar arteries was associated with a low mortality and morbidity rate and with a high degree of patency. This technique may therefore be regarded as an effective means of improving the patency of stenotic arteries. In selective cases, it might be considered for use prophylactically.
authors.affiliation: Department of Neuroradiology, Alfried-Krupp Krankenhaus, Essen, Germany.
authors.forename: H C
authors.initials: HC
authors.lastname: Nahser
authors.forename: H
authors.initials: H
authors.lastname: Henkes
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: E
authors.initials: E
authors.lastname: Berg-Dammer
authors.forename: T A
authors.initials: TA
authors.lastname: Yousry
authors.forename: D
authors.initials: D
authors.lastname: Kühne
mesh_terms: D000368:Aged; D015901:Angiography, Digital Subtraction; D000800:Angioplasty, Balloon; D002533:Cerebral Angiography; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014715:Vertebrobasilar Insufficiency / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*