title: Improving door to needle times with nurse initiated thrombolysis.
abstract: OBJECTIVE
  To evaluate the effect of nurse initiated thrombolysis on door to needle time (the interval between arriving at the hospital and starting thrombolytic treatment) in patients with acute myocardial infarction.
  
  
  METHODS
  Comparison of door to needle times before and after the employment of nurses trained and approved to initiate thrombolysis without prescription by a doctor but with a protocol for rapid triage of patients with chest pain.
  
  
  METHODS
  A district general hospital.
  
  
  METHODS
  All patients admitted with suspected myocardial infarction between April 1995 and March 1999.
  
  
  METHODS
  Speed (door to needle time) and appropriateness of administration of thrombolytic drugs to patients with acute myocardial infarction who gave a characteristic history and had appropriate criteria on the admission ECG.
  
  
  RESULTS
  During seven periods (each of four months) before the introduction of nurse initiated thrombolysis and a new chest pain triage protocol, the median door to needle time varied from 50-58 minutes. In four periods (each of 4-6 months) following the introduction of the changes, the median door to needle time was 25-30 minutes. The improvement was significant (p < 0.001). Nurses trained to initiate thrombolysis currently provide cover for 66% of the time. Median door to needle time for nurses was 15 minutes. Median door to needle time for junior doctors improved to 35 minutes. The median door to needle times when nurses initiated thrombolysis was significantly shorter than when doctors did so (p < 0.001). There have been no inappropriate management decisions by nurses approved to initiate thrombolysis.
  
  
  CONCLUSIONS
  The use of nurse initiated thrombolysis has resulted in a clinically important reduction in the time taken for thrombolysis to be started in patients with acute myocardial infarction.
authors.affiliation: Department of Cardiology, Royal Shrewsbury Hospital, Shrewsbury SY3 8XQ, UK.
authors.forename: P
authors.initials: P
authors.lastname: Wilmshurst
authors.forename: A
authors.initials: A
authors.lastname: Purchase
authors.forename: C
authors.initials: C
authors.lastname: Webb
authors.forename: C
authors.initials: C
authors.lastname: Jowett
authors.forename: T
authors.initials: T
authors.lastname: Quinn
mesh_terms: D003325:Coronary Care Units; D004630:Emergencies; D006801:Humans; D008485:Medical Audit; D008505:Medical Staff, Hospital; D009203:Myocardial Infarction / Q000188:drug therapy*; D009722:Nurse Practitioners; D009731:Nursing Audit; D015912:Thrombolytic Therapy / Q000379:methods / Q000451:nursing*; D013997:Time Factors