High plasma concentrations of prorenin in a transgenic animal model of nephropathy with overexpression of transforming growth factor-beta1 in the kidneys.
1. Plasma concentrations of prorenin were determined in a transgenic animal model of nephropathy induced by overexpression of transforming growth factor (TGF)-beta1 in the juxtaglomerular apparatus. 2. In both female and male mice, plasma concentrations of prorenin were higher in transgenic than in non-transgenic animals. In sexually mature mice, plasma prorenin concentrations were higher in males than in females in both transgenic and non-transgenic animals in accordance with a sexual dimorphism of the plasma concentration of prorenin. 3. The results indicate that TGF-beta1-like androgens increase prorenin secretion in the kidneys and may explain the increased plasma prorenin concentrations in patients with diabetic nephropathy.
Krag
S
S
Research Laboratory for Biochemical Pathology, Aarhus Kommunehospital, Denmark.
Nielsen
A H
AH
Wogensen
L
L
D000375:Aging / Q000097:blood; D000818:Animals; D003929:Diabetic Neuropathies / Q000097:blood*; D004195:Disease Models, Animal; D004792:Enzyme Precursors / Q000097:blood*; D005260:Female; D007606:Juxtaglomerular Apparatus / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D012083:Renin / Q000097:blood*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics; D053773:Transforming Growth Factor beta1
D004792:Enzyme Precursors; C508961:Tgfb1 protein, mouse; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D012083:Renin