[Hypoxemia and tissue hypoxia in sleep apnea syndrome].
Hypoxemia is defined as abnormally reduced oxygenation of the blood, whereas tissue hypoxia indicates inadequate oxygen supply against oxygen demand in the integrity of cellular metabolic processes. Thus, the presence of tissue hypoxia may not be predicted by the level of hypoxemia alone. Obstructive sleep apnea syndrome is characterized by periodic apnea/hypopnea, which is often associated with severe hypoxemia. In this chapter, we discussed how tissue hypoxia should be assessed in this syndrome, and also what is the clinical usefulness and/or limitations of such assessment.
Tsujino
I
I
First Department of Medicine, Hokkaido University School of Medicine.
Nishimura
M
M
D000255:Adenosine Triphosphate / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000209:etiology; D009211:Myoglobin / Q000032:analysis; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared; D014527:Uric Acid / Q000652:urine
D015415:Biomarkers; D006454:Hemoglobins; D009211:Myoglobin; D014527:Uric Acid; D000255:Adenosine Triphosphate