title: What are oligomerization domains good for?
abstract: Collagen triple helices, coiled coils and other oligomerization domains mediate the subunit assembly of a large number of proteins. Oligomerization leads to functional advantages of multivalency and high binding strength, increased structure stabilization and combined functions of different domains. These features seen in naturally occurring proteins can be engineered by protein design by combining oligomerization domains with functional domains.
authors.affiliation: Abteilung für Biophysikalische Chemie,Biozentrum der Universität Basel, CH 4056, Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Engel
authors.forename: R A
authors.initials: RA
authors.lastname: Kammerer
mesh_terms: D000818:Animals; D003094:Collagen / Q000737:chemistry*; D003432:Cross-Linking Reagents; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry*; D015202:Protein Engineering; D017434:Protein Structure, Tertiary
chemical_list: D003432:Cross-Linking Reagents; D009842:Oligopeptides; D003094:Collagen