title: Fibroblast growth factor signalling and cyclin D1 function are necessary for normal mammary gland development during pregnancy. A transgenic mouse approach.
abstract: A number of growth factors, growth factor receptors and cell cycle regulatory proteins have been implicated in the genesis of mammary carcinomas both in animal models as well as in human breast tumour samples. Studies on the development of the mammary gland has revealed that several of the proto-oncogenes, or their closely related gene-family members, have a function in the normal growth and differentiation of the gland. In this review the role of fibroblast growth factor signalling and the critical requirement for the cell cycle regulator, cyclin D1 is discussed with respect to their normal function in mammary gland development and abnormal role in mammary carcinogenesis.
authors.affiliation: Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
authors.forename: V
authors.initials: V
authors.lastname: Fantl
authors.forename: A
authors.initials: A
authors.lastname: Creer
authors.forename: C
authors.initials: C
authors.lastname: Dillon
authors.forename: J
authors.initials: J
authors.lastname: Bresnick
authors.forename: D
authors.initials: D
authors.lastname: Jackson
authors.forename: P
authors.initials: P
authors.lastname: Edwards
authors.forename: I
authors.initials: I
authors.lastname: Rosewell
authors.forename: C
authors.initials: C
authors.lastname: Dickson
mesh_terms: D000818:Animals; D001940:Breast / Q000473:pathology / Q000502:physiology*; D001943:Breast Neoplasms / Q000473:pathology / Q000503:physiopathology; D019938:Cyclin D1 / Q000502:physiology*; D005260:Female; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D008321:Mammary Glands, Animal / Q000473:pathology / Q000502:physiology*; D015674:Mammary Neoplasms, Animal / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D008822:Mice, Transgenic; D011247:Pregnancy / Q000502:physiology*; D011270:Pregnancy, Animal / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D019938:Cyclin D1; D005346:Fibroblast Growth Factors