title: Spatial working memory is independent of hippocampal CA1 long-term potentiation in rats.
abstract: This study investigated the relationship between spatial working memory and hippocampal long-term potentiation (LTP) using the allocentric place discrimination task (APDT) in rats, in which the selection accuracy is a good index for spatial working memory. Either the selective M1 muscarinic receptor antagonist pirenzepine (50 microg) or the choline uptake inhibitor hemicholinium-3 (5 microg) impaired APDT selection accuracy, but neither affected the induction of LTP in the hippocampal CA1 region in anesthetized rats. In contrast, the selective N-methyl-D-aspartate receptor antagonist D-amino-5-phosphonopentanoate (200 nmol) did not impair APDT selection accuracy but completely blocked hippocampal CA1 LTP. These results suggest that spatial working memory is independent of hippocampal CA1 LTP and that the central cholinergic system is involved in spatial working memory, but not through the modulation of hippocampal CAI LTP.
authors.affiliation: Department of Animal Resource Science/Veterinary Medical Science, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kikusui
authors.forename: A
authors.initials: A
authors.lastname: Aoyagi
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
mesh_terms: D000818:Animals; D001931:Brain Mapping; D018678:Cholinergic Agents / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D006426:Hemicholinium 3 / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007276:Injections, Intraventricular; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009949:Orientation / Q000187:drug effects / Q000502:physiology*; D010890:Pirenzepine / Q000494:pharmacology; D051381:Rats; D011916:Rats, Inbred F344; D043643:Receptor, Muscarinic M1; D011976:Receptors, Muscarinic / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D014633:Valine / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D018678:Cholinergic Agents; D043643:Receptor, Muscarinic M1; D011976:Receptors, Muscarinic; D016194:Receptors, N-Methyl-D-Aspartate; D006426:Hemicholinium 3; D010890:Pirenzepine; C056639:2-amino-5-phosphopentanoic acid; D014633:Valine