title: Identification of a chemical tool for the orphan nuclear receptor FXR.
authors.affiliation: Department of Medicinal Chemistry, Glaxo Wellcome Research & Development, Research Triangle Park, North Carolina 27709, USA. prm8279@glaxowellcome.com
authors.forename: P R
authors.initials: PR
authors.lastname: Maloney
authors.forename: D J
authors.initials: DJ
authors.lastname: Parks
authors.forename: C D
authors.initials: CD
authors.lastname: Haffner
authors.forename: A M
authors.initials: AM
authors.lastname: Fivush
authors.forename: G
authors.initials: G
authors.lastname: Chandra
authors.forename: K D
authors.initials: KD
authors.lastname: Plunket
authors.forename: K L
authors.initials: KL
authors.lastname: Creech
authors.forename: L B
authors.initials: LB
authors.lastname: Moore
authors.forename: J G
authors.initials: JG
authors.lastname: Wilson
authors.forename: M C
authors.initials: MC
authors.lastname: Lewis
authors.forename: S A
authors.initials: SA
authors.lastname: Jones
authors.forename: T M
authors.initials: TM
authors.lastname: Willson
mesh_terms: D000818:Animals; D001682:Biological Availability; D002460:Cell Line; D002474:Cell-Free System; D020650:Combinatorial Chemistry Techniques; D004268:DNA-Binding Proteins / Q000819:agonists*; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists*; D014162:Transfection; D014280:Triglycerides / Q000097:blood; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D004268:DNA-Binding Proteins; D007555:Isoxazoles; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014280:Triglycerides; D000099150:Receptor, Farnesoid X-Activated; C412815:GW 4064