[Genetic transcription in eukaryotes: from transcriptional factors to disease].
The organisms' genetic information is stored as DNA sequences: the genes. The most important level of gene expression regulation is exerted at the transfer process of this information from the genes into messenger RNA molecules; this process is called transcription and is carried out by a molecular machinery conformed by hundreds of different proteins which are assembled in an ordered step way. These proteins or transcriptional factors are classified according to their mode of action in 4 groups: general transcriptional factors, activators, coactivators and repressors. There are diseases like. Aniridia, the Rubinstein-Taybi syndrome and Hodgkin's disease, in which some transcriptional factor have been involved and in some, the molecular cause i.e. the mutations responsible for the molecular dysfunction in a transcriptional factor has been elucidated. Understanding at the molecular level the transcription process will help to comprehend the relationship of it with the development and health of the organism.
Moreno Rocha
J C
JC
Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, México.
Revol de Mendoza
A
A
Barrera Saldaña
H A
HA
D005057:Eukaryotic Cells; D030342:Genetic Diseases, Inborn / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
D014157:Transcription Factors