Detection and quantification of CD4(+) T cells with specificity for a new major histocompatibility complex class II-restricted influenza A virus matrix protein epitope in peripheral blood of influenza patients.
FVFTLTVPS was identified as the core sequence of a new major histocompatibility complex class II-restricted T-cell epitope of influenza virus matrix protein. Epitope-specific CD4(+) T cells were detected in the peripheral blood of patients with frequencies of up to 0.94%, depending on the number of additional terminal amino acids.
Linnemann
T
T
Department of Dermatology and Allergy, Charité, Medical School of the Humboldt University, D-10089 Berlin, Germany.
Jung
G
G
Walden
P
P
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte; D005802:Genes, MHC Class II / Q000276:immunology*; D015804:HLA-DR4 Antigen / Q000032:analysis / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D007251:Influenza, Human / Q000097:blood / Q000276:immunology* / Q000821:virology; D014763:Viral Matrix Proteins / Q000097:blood / Q000276:immunology*
D000596:Amino Acids; D018984:Epitopes, T-Lymphocyte; D015804:HLA-DR4 Antigen; C031540:M-protein, influenza virus; D014763:Viral Matrix Proteins