Endogenous and ectopic gland induction by FGF-10.
FGF-10, a member of the fibroblast growth factor family, is expressed in mesodermally derived cell populations during embryogenesis. During normal ocular development, FGF-10 is expressed in the perioptic mesenchyme adjacent to the Harderian and lacrimal gland primordia. In this report, we provide evidence that FGF-10 is both necessary and sufficient to initiate glandular morphogenesis. Lens-specific expression of FGF-10 was sufficient to induce ectopic ocular glands within the cornea. In addition, lacrimal and Harderian glands were not seen in FGF-10 null fetuses. Based on these results we propose that FGF-10 is an inductive signal that initiates ocular gland morphogenesis.
Govindarajan
V
V
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA.
Ito
M
M
Makarenkova
H P
HP
Lang
R A
RA
Overbeek
P A
PA
D000818:Animals; D004627:Embryonic Induction; D005314:Embryonic and Fetal Development; D051526:Fibroblast Growth Factor 10; D005346:Fibroblast Growth Factors / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006243:Harderian Gland / Q000196:embryology* / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic
C496464:Fgf10 protein, mouse; D051526:Fibroblast Growth Factor 10; D005346:Fibroblast Growth Factors