title: Significant increase in antigastric autoantibodies in a long-term follow-up study of H. pylori gastritis.
abstract: In 30% of H. pylori-infected patients a certain type of antigastric autoantibodies, reacting against canalicular structures within human parietal cells, is detectable. Furthermore, it has been shown that these autoantibodies are correlated with atrophy of the mucosa in the corpus. The aim of this study was to analyse the prevalence of these anticanalicular autoantibodies (ACAB) and their significance for development of gastric mucosa atrophy in a 12-year follow-up period. Gastric biopsy specimens from 62 persons in Saaremaa Island, Estonia, were collected in 1997 and assessed independently by two pathologists in accordance with the updated Sydney system. The sera of these persons were immunohistochemically screened for ACAB and for classic parietal cell antibodies (PCA). In addition, for 37 of the 62 persons, gastric biopsies and sera collected 12 years earlier (1985) were investigated in an analogous manner. ACAB increased significantly, from 8 out of 37 in 1985 to 17 out of 37 in 1997 (P=0.004; McNemar test). In 1997 a significant correlation existed between the presence of ACAB and corpus mucosa atrophy (19 out of 30 versus 10 out of 32 without atrophy; P=0.01; odds ratio (OR)=3.8, 95% CI 1.4-10.6). However, no correlation was found between ACAB and development of atrophy in the period from 1985 to 1997. All 37 persons were PCA negative in 1985, whereas in 1997, 2 turned out to be PCA positive. ACAB increased significantly with duration of H. pylori gastritis. The correlation between ACAB and presence of gastric corpus atrophy was confirmed. However, it is possible that ACAB are the consequence of and not a causative factor in gastric mucosa atrophy, insofar as the association of ACAB with progression of corpus atrophy was not significant.
authors.affiliation: Department of Immunology, University of Tartu, Estonia. tamara.vorobjova@kliinikum.ee
authors.forename: T
authors.initials: T
authors.lastname: Vorobjova
authors.forename: G
authors.initials: G
authors.lastname: Faller
authors.forename: H I
authors.initials: HI
authors.lastname: Maaroos
authors.forename: P
authors.initials: P
authors.lastname: Sipponen
authors.forename: K
authors.initials: K
authors.lastname: Villako
authors.forename: R
authors.initials: R
authors.lastname: Uibo
authors.forename: T
authors.initials: T
authors.lastname: Kirchner
mesh_terms: D000368:Aged; D001284:Atrophy; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology; D016481:Helicobacter Infections / Q000276:immunology* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000276:immunology*
chemical_list: D001323:Autoantibodies