Prognostic value of ischemia monitoring with on-line vectorcardiography in patients with unstable coronary artery disease.
OBJECTIVE
The aim of this study was to determine whether on-line vectorcardiography (VCG) gives independent prognostic information, regarding death, myocardial infarction (MI), and revascularization in patients with unstable coronary artery disease, i.e. unstable angina or non-Q-wave MI.


RESULTS
One hundred and fifty patients (mean age 69 +/- 10), participating in a randomized study of low-molecular-weight heparin in unstable coronary artery disease, were studied with on-line VCG recordings for 24 h. During a 5-6-month follow-up, 11 patients died, 14 suffered a nonfatal MI and 31 were revascularized. Univariate predictors of death were diabetes mellitus (p < 0.01), maximum ST vector magnitude (ST-VM; p < 0.001), maximum ST change vector magnitude (STC-VM; p < 0.001), number of ST-VM (p < 0.01) and STC-VM episodes (p < 0.001). In multivariate analysis, the number of STC-VM episodes (p < 0.01) and diabetes mellitus (p < 0.02) each gave independent prognostic information regarding death. When all cardiovascular events were combined, the inability to perform an exercise test (p < 0.05), maximum value of ST-VM (p < 0.01) and STC-VM (p < 0.001), the number of episodes of STC-VM (p < 0.001) and ST-VM (p < 0.001) all gave prognostic information. In multivariate analysis, the inability to perform an exercise test and the number of STC-VM episodes were independent predictors.


CONCLUSIONS
VCG monitoring during the first 24 h of hospitalization for unstable coronary artery disease gives independent prognostic information.
Lundin
P
P
Department of Medicine, Norrtälje Hospital, Stockholm, Sweden.
Jensen
J
J
Lindahl
B
B
Wallentin
L
L
Eriksson
S V
SV
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology; D000925:Anticoagulants / Q000008:administration & dosage*; D002423:Cause of Death; D005080:Exercise Test; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D009862:Online Systems; D011379:Prognosis; D015996:Survival Rate; D013686:Telemetry / Q000379:methods*; D014672:Vectorcardiography / Q000187:drug effects / Q000379:methods*
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight