title: Design and synthesis of substituted compounds containing the 1, 4-benzodioxin subunit. New potential calcium antagonists.
abstract: New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists.
authors.affiliation: Laboratori de Química Farmacèutica, Fac. Farmàcia, Universitat de Barcelona, Avda. Diagonal 643, 08028, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Sánchez
authors.forename: M
authors.initials: M
authors.lastname: Dolors Pujol
authors.forename: G
authors.initials: G
authors.lastname: Guillaumet
authors.forename: R
authors.initials: R
authors.lastname: Massingham
authors.forename: A
authors.initials: A
authors.lastname: Monteil
authors.forename: G
authors.initials: G
authors.lastname: Dureng
authors.forename: E
authors.initials: E
authors.lastname: Winslow
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002147:Calmodulin / Q000037:antagonists & inhibitors; D004147:Dioxins / Q000737:chemistry*; D015195:Drug Design; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D011817:Rabbits; D013055:Spectrophotometry, Infrared
chemical_list: D002121:Calcium Channel Blockers; D002147:Calmodulin; D004147:Dioxins