title: Extracorporeal irradiation of tumorous calvaria. Case report.
abstract: This patient with recurrent meningioma grossly involving the frontal bone underwent craniotomy and tumor resection. During the procedure a bone flap was irradiated extracorporeally at a very high dose (120 Gy) sufficient to sterilize residual tumor cells, and the bone was then successfully replaced orthotopically for reconstruction. The use of autologous irradiated bone in this setting offers advantages over cadaveric transplantation and prosthetic implants. Radiation might cause less disruption of the bone's architecture than other techniques of tumor cell eradication.
authors.affiliation: Department of Radiation Oncology, Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond 23298-0058, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Manning
authors.forename: R M
authors.initials: RM
authors.lastname: Cardinale
authors.forename: R K
authors.initials: RK
authors.lastname: Schmidt-Ullrich
authors.forename: B D
authors.initials: BD
authors.lastname: Kavanagh
authors.forename: I L
authors.initials: IL
authors.lastname: Wornom
authors.forename: W C
authors.initials: WC
authors.lastname: Broaddus
mesh_terms: D003399:Craniotomy; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008579:Meningioma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D012886:Skull / Q000637:transplantation; D012888:Skull Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D013524:Surgical Flaps; D014182:Transplantation, Autologous