Pattern of expression of the transcription factor Krox-20 in mouse hair follicle.
We examined the pattern of expression in hair follicles of the transcription factor gene Krox-20. During embryogenesis, Krox-20 is first expressed in the upper portion of the hair bud, then in the hair canal, in the sebaceous glands and in the outer root sheath. In the mature follicles, Krox-20, like Shh and TGFbetaRII, is also expressed in a sub-population of matrix keratinocytes located in a ring-like fashion in vibrissal follicles and clustered on one side of the papilla in pelage follicles. This polarized pattern rotates around the papilla as a result of sequential gene expression by individual groups of matrix cells. This peculiar pattern is not linked to follicle angling.
Gambardella
L
L
Laboratoire de Différenciation Epithéliale, Ecole Normale Supérieure, 46, Rue d'Ulm, 75230, Cedex 05, Paris, France.
Schneider-Maunoury
S
S
Voiculescu
O
O
Charnay
P
P
Barrandon
Y
Y
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D051767:Early Growth Response Protein 2; D018507:Gene Expression Regulation, Developmental; D017781:Genes, Immediate-Early; D018859:Hair Follicle / Q000196:embryology* / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007763:Lac Operon; D051379:Mice; D008822:Mice, Transgenic; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D017931:DNA Primers; D004268:DNA-Binding Proteins; D051767:Early Growth Response Protein 2; C497327:Egr2 protein, mouse; D014157:Transcription Factors