title: A trial of oats in children with newly diagnosed celiac disease.
abstract: OBJECTIVE
  To determine whether consumption of oats is safe in children with newly diagnosed celiac disease who are starting a gluten-free diet.
  
  
  METHODS
  We conducted a self-controlled, open-label, 6-month trial of a commercial oat breakfast cereal product. Primary outcome variables were small bowel histomorphology and anti-tissue transglutaminase IgA antibody titer.
  
  
  RESULTS
  The 10 children who completed the study were 6.8 +/- 4.0 (mean +/- SD) years of age and 5 were male. Over 6.6 +/- 0.7 months, they consumed 24 grams of oat cereal per day, or 1.2 +/- 0.9 g/kg/d. Compared with start of study, at completion there was a significant decrease in biopsy score (P <.01), intra-epithelial lymphocyte count (P <.005), anti-tissue transglutaminase IgA antibody titer (P <.01), and number of symptoms (P <.01).
  
  
  CONCLUSIONS
  We conclude that consumption of a commercially available oat cereal product for 6 months is safe for children with celiac disease beginning a gluten-free diet. Studies are needed to determine the long-term safety of including oat cereal in the gluten-free diet.
authors.affiliation: Section of Pediatric Gastroenterology, Hepatology, and Nutrition, Center for Pediatric Inflammatory Bowel Diseases, Department of Pediatrics, The Children's Hospital, Denver, Colorado, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Hoffenberg
authors.forename: J
authors.initials: J
authors.lastname: Haas
authors.forename: A
authors.initials: A
authors.lastname: Drescher
authors.forename: R
authors.initials: R
authors.lastname: Barnhurst
authors.forename: I
authors.initials: I
authors.lastname: Osberg
authors.forename: F
authors.initials: F
authors.lastname: Bao
authors.forename: G
authors.initials: G
authors.lastname: Eisenbarth
mesh_terms: D018554:Avena; D002446:Celiac Disease / Q000175:diagnosis / Q000178:diet therapy* / Q000276:immunology / Q000473:pathology; D002648:Child; D005260:Female; D005983:Glutens; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007421:Intestine, Small / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D018655:Lymphocyte Count; D008297:Male; D011863:Radioimmunoassay; D018709:Statistics, Nonparametric; D011503:Transglutaminases / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D005983:Glutens; D011503:Transglutaminases