[(18)F]p-MPPF: aA radiolabeled antagonist for the study of 5-HT(1A) receptors with PET.
This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism.
Plenevaux
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Cyclotron Research Center, Liège University, Sart Tilman B.30, B-4000 Liège, Belgium. Alain.Plenevaux@ulg.ac.be
Lemaire
C
C
Aerts
J
J
Lacan
G
G
Rubins
D
D
Melega
W P
WP
Brihaye
C
C
Degueldre
C
C
Fuchs
S
S
Salmon
E
E
Maquet
P
P
Laureys
S
S
Damhaut
P
P
Weissmann
D
D
Le Bars
D
D
Pujol
J F
JF
Luxen
A
A
D000631:Aminopyridines / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry; D002415:Cats; D005462:Fluorine Radioisotopes; D006801:Humans; D008024:Ligands; D010879:Piperazines / Q000378:metabolism*; D051381:Rats; D011985:Receptors, Serotonin / Q000032:analysis*; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D000631:Aminopyridines; D005462:Fluorine Radioisotopes; D008024:Ligands; D010879:Piperazines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; C099463:4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine