Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.
Covey
D F
DF
Departments of Molecular Biology and Pharmacology, Anesthesiology, Psychiatry, and Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, USA.
Han
M
M
Kumar
A S
AS
de La Cruz
M A
MA
Meadows
E S
ES
Hu
Y
Y
Tonnies
A
A
Nathan
D
D
Coleman
M
M
Benz
A
A
Evers
A S
AS
Zorumski
C F
CF
Mennerick
S
S
D000777:Anesthetics / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D018360:Crystallography, X-Ray; D004594:Electrophysiology; D006718:Homosteroids / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D008968:Molecular Conformation; D009865:Oocytes; D011278:Pregnanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism / Q000502:physiology; D013329:Structure-Activity Relationship; D014982:Xenopus laevis
D000777:Anesthetics; D006718:Homosteroids; D011278:Pregnanes; D011963:Receptors, GABA-A