title: Nail involvement in pemphigus vulgaris.
abstract: Nail involvement in pemphigus vulgaris is relatively rare. We describe a case of severe pemphigus involving both the skin and oral mucosa in which an acute exacerbation was preceded by the onset of nail involvement of all 4 extremities. Nail involvement occurred in the form of hemorrhagic paronychia of multiple digits. Oral, cutaneous, and nail manifestations of the disease were all well controlled by systemic therapy. A review of the literature on nail involvement in pemphigus reveals that this involvement may be manifested in multiple ways, with chronic paronychia and onychomadesis being the most common. Involvement of the nail occurs most frequently either as part of the initial presentation, or just before or concurrent with a flare of pre-existing disease. Nail involvement, when it occurs, is usually present when the disease is severe. Topical therapy is insufficient, and systemic therapy is warranted. In the majority of cases, nail recovery is complete, with no residual damage.
authors.affiliation: Harvard School of Dental Medicine, and the Department of Dermatology, Boston University School of Medicine, MA 02115, USA.
authors.forename: L
authors.initials: L
authors.lastname: Engineer
authors.forename: L A
authors.initials: LA
authors.lastname: Norton
authors.forename: A R
authors.initials: AR
authors.lastname: Ahmed
mesh_terms: D005528:Foot; D006225:Hand; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D010392:Pemphigus / Q000150:complications* / Q000473:pathology; D012008:Recurrence
chemical_list: D016756:Immunoglobulins, Intravenous