[Molecular nutrition, role of the PPAR system in lipidic metabolism and its importance in obesity and diabetes mellitus].
PPARs are transcription factors belonging to the super family of hormonal receptors. Their activity is regulated by fibrates, thiazolidinediones, certain anti inflammatory drugs and fatty acid derivatives, present in food. PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (PPAR gamma) and catabolic (PPAR alpha) pathways of lipid metabolism. Additionally, these receptors participate in glucose homeostasis, influence cellular proliferation and differentiation and participate in inflammatory processes. The effects of PPARs on oxidative substrate partitioning suggests that they have a relevant role in the development of obesity and insulin resistance.
Uauy
R
R
Laboratorio de Biología Molecular, Instituto de Nutrición y Tecnología de los Alimentos INTA, Universidad de Chile, Santiago, Chile.
Martínez
J I
JI
Rojas
C V
CV
D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors