title: Lifestyle factors and insulin-like growth factor 1 levels among elderly men.
abstract: Insulin-like growth factor 1 (IGF-1) is a potentially important determinant of disease; hence epidemiological identification of factors that influence circulating IGF-1 is merited. We therefore analysed data collected in Greece to determine the relationship between anthropometric, lifestyle and dietary variables and serum levels of IGF-1 among elderly men. We identified 51 men with prostate cancer, 50 men with benign prostatic hyperplasia, and 52 apparently healthy elderly men (controls), all matched for age (+/- 1 year). These 153 men provided blood specimens and were interviewed using a validated lifestyle and food frequency questionnaire. We performed multivariate linear regression to identify potential predictors of circulating IGF-1. After controlling for age, body mass index, smoking habits, alcohol drinking and coffee consumption, each 5 cm increase in height predicted a 13.0% increase in IGF-1 (95% CI 0.4-27.2%) among the controls and a 11.3% increase in IGF-1 (95% CI 4.5-18.6%) among the entire study group. None of the investigated dietary factors (total fat, carbohydrate, protein, dairy products, tomatoes, calcium) were strongly related to IGF-1 levels. The positive association between IGF-1 and height integrates the empirical evidence linking IGF-1 and height with prostate cancer risk.
authors.affiliation: Department of Epidemiology and Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: L B
authors.initials: LB
authors.lastname: Signorello
authors.forename: H
authors.initials: H
authors.lastname: Kuper
authors.forename: P
authors.initials: P
authors.lastname: Lagiou
authors.forename: J
authors.initials: J
authors.lastname: Wuu
authors.forename: L A
authors.initials: LA
authors.lastname: Mucci
authors.forename: D
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: H O
authors.initials: HO
authors.lastname: Adami
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology; D016022:Case-Control Studies; D015897:Comorbidity; D004032:Diet; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008019:Life Style; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D012016:Reference Values; D012907:Smoking / Q000453:epidemiology
chemical_list: D007334:Insulin-Like Growth Factor I