title: Etiology and pathogenesis of rheumatic diseases of adolescence.
abstract: The pathogenesis of SLE is multifactorial. Immune complexes, autoantibodies, and abnormal T-lymphocyte responses all play a part. Genetic predispositions are present, but not as strongly expressed as in the spondylarthropathies. Environmental agents and the effects of sex hormones also contribute.
authors.affiliation: Department of Paediatrics, University of British Columbia, Canada.
authors.forename: R E
authors.initials: RE
authors.lastname: Petty
mesh_terms: D000293:Adolescent; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001323:Autoantibodies / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D003167:Complement Activation; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D008297:Male; D051379:Mice; D012216:Rheumatic Diseases / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D012737:Sex Factors
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D016207:Cytokines; D016718:Arachidonic Acid