title: Dramatic decline in circulating intercellular adhesion molecule-1 concentration on quitting tobacco smoking.
abstract: The concentration of soluble ICAM-1 (sICAM-1) is significantly elevated in smokers, but it is unclear if smoking is the direct cause of elevated sICAM-1 levels, if the relationship between smoking and sICAM-1 level is dose-dependent, and if smoking cessation may lead to a decline in sICAM-1. We sought to clarify the relationship between smoking and sICAM-1 in a group of smokers who quit smoking for 1 year (n = 30) and a control group who continued to smoke (n = 30). A dose-dependent relationship between plasma sICAM-1 concentration and daily cigarette consumption (P = 0.02), plasma cotinine level (P = 0.02), and expired CO level (P = 0.007) was observed at baseline (n = 60). The mean change in sICAM-1 concentration after 52 weeks was greater for quitters than for continuing smokers (mean difference = -71.1 ng/ml, P < 0.001). The influence of smoking on sICAM-1 needs to be carefully considered in clinical trials. Soluble ICAM-1 remains bioactive and may contribute to pathogenic processes; therefore, reduction in the concentration of circulating ICAM-1 molecules may directly contribute to the health benefits associated with smoking cessation.
authors.affiliation: Dental Clinical Research, King's College London, London, United Kingdom. david.2.scott@kcl.ac.uk
authors.forename: D A
authors.initials: DA
authors.lastname: Scott
authors.forename: J A
authors.initials: JA
authors.lastname: Stapleton
authors.forename: R F
authors.initials: RF
authors.lastname: Wilson
authors.forename: G
authors.initials: G
authors.lastname: Sutherland
authors.forename: R M
authors.initials: RM
authors.lastname: Palmer
authors.forename: P Y
authors.initials: PY
authors.lastname: Coward
authors.forename: G
authors.initials: G
authors.lastname: Gustavsson
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D012044:Regression Analysis; D012907:Smoking / Q000097:blood*; D016540:Smoking Cessation; D013997:Time Factors
chemical_list: D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1