Intravenous treatment with immunoglobulins may improve chronic undifferentiated mono- and oligoarthritis.
We previously reported on 8 young patients with undifferentiated mono- and oligoarthritis whose synovial tissue tested positive for Parvovirus B19 DNA by PCR. Three of these patients remained clinically undifferentiated and suffered from progressive inflammatory disease despite conventional therapy and repeated synovectomy. Intravenous treatment with immunoglobulin (0.4 g/kg body weight over 5 days) resulted in marked improvement in 2 of the 3 patients, allowing them to avoid repeated synovectomy during follow-up periods of 7 and 10 months, respectively.
Stahl
H D
HD
Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Germany. stah@medizin.uni-leipzig.de
Pfeiffer
R
R
Emmrich
F
F
D000293:Adolescent; D000328:Adult; D001170:Arthritis, Infectious / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications*; D016732:Parvovirus B19, Human; D000074402:Synovectomy; D013583:Synovial Membrane / Q000473:pathology
D016756:Immunoglobulins, Intravenous