Leukocyte recruitment during pulmonary Cryptococcus neoformans infection.
Leukocyte recruitment to the site of infection by the encapsulated yeast Cryptococcus neoformans is critical for clearance of the infection. We review data from our lab that chemokines, such as the CC chemokines MCP-1 and MIP-1alpha, are important mediators of leukocyte recruitment during C. neoformans infection. In addition, studies in CC chemokine receptor knockout mice have demonstrated that CCR2 and CCR5 are required not only for leukocyte recruitment but also for other aspects of immune response development and innate imunity to C. neoformans.
Huffnagle
G B
GB
Pulmonary Division, University of Michigan Medical School, Ann Arbor, MI 48109-0642, USA. ghuff@umich.edu
Traynor
T R
TR
McDonald
R A
RA
Olszewski
M A
MA
Lindell
D M
DM
Herring
A C
AC
Toews
G B
GB
D000818:Animals; D018932:Chemokine CCL2 / Q000276:immunology; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018925:Chemokines / Q000276:immunology*; D003453:Cryptococcosis / Q000276:immunology*; D003455:Cryptococcus neoformans; D006801:Humans; D007111:Immunity, Cellular; D007962:Leukocytes / Q000276:immunology*; D019402:Macrophage Inflammatory Proteins / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000276:immunology; D019707:Receptors, Chemokine / Q000276:immunology*
C515334:CCR2 protein, human; C515335:Ccr2 protein, mouse; D018932:Chemokine CCL2; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018925:Chemokines; D019402:Macrophage Inflammatory Proteins; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine