title: Basic mechanisms of secretion: sorting into the regulated secretory pathway.
abstract: Targeting proteins to their correct cellular location is crucial for their biological function. In neuroendocrine cells, proteins can be secreted by either the constitutive or the regulated secretory pathways but the mechanism(s) whereby proteins are sorted into either pathway is unclear. In this review we discuss the possibility that sorting is either an active process occurring at the level of the trans-Golgi network, or that sorting occurs passively in the immature granules, The possible involvement of protein-lipid interactions in the sorting process is also raised.
authors.affiliation: Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill.
authors.forename: M
authors.initials: M
authors.lastname: Blázquez
authors.forename: K I
authors.initials: KI
authors.lastname: Shennan
mesh_terms: D000818:Animals; D012634:Bodily Secretions; D050356:Lipid Metabolism; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism*; D015398:Signal Transduction; D021601:trans-Golgi Network / Q000378:metabolism
chemical_list: D011506:Proteins