Prenatal exposure of an alcoholic beverage (Arrack) on fetal lipid metabolism in rats.
The objective of this study was to determine the effects of a country liquor (Arrack) and the equivalent quantity of ethanol on liver function and lipid metabolism in utero. Female rats of average weight 125 g were exposed to Arrack (12 ml/kg body weight/day) and ethanol (3.2 ml/kg body weight/day) for 15 days before conception and throughout gestation. On 13th day and 19th day of gestation, altered liver function and hyperlipidemia was seen in the fetus of both the treated groups. Altered liver function was evidenced by the increased activity of alcohol dehydrogenase and glutamic pyruvic transaminase or alanine amino transferase (GPT). Hyperlipidemia was caused by increased biosynthesis since the incorporation of 14C acetate to lipids and activities of HMG CoA reductase and lipogenic enzymes were elevated. Arrack seemed to potentiate the toxicity induced by alcohol indicating the role of non ethanolic portion. Hepatic functions of the 13th day fetuses were effected to a lesser degree than the 19th day hepatic liver.
Lal
J J
JJ
Department of Biochemistry, University of Kerala, Kariyavattom, Trivandrum.
Kumar
C V
CV
Suresh
M V
MV
Indira
M
M
Vijayammal
P L
PL
D000434:Alcoholic Beverages / Q000633:toxicity*; D000818:Animals; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D000431:Ethanol; D006903:Hydroxymethylglutaryl CoA Reductases