Prognostic significance of the Ca(2+) binding protein S100A2 in laryngeal squamous-cell carcinoma.
We investigated by immunocytochemistry the expression of the Ca(2+) binding protein S100A2 in 62 cases of laryngeal squamous-cell carcinoma (SCC). S100A2 was detected in 18/19 (95%) low-grade tumors and in 22/43 (51%) high-grade tumors, which were partially keratinizing. The remaining 21/43 (49%) high-grade tumors were non-keratinizing, anaplastic tumors and clearly S100A2-negative. In normal laryngeal squamous epithelium and in laryngeal SCC, S100A2 expression was strictly associated with that of cytokeratins 14 (P = 0.0002) and 17 (P = 0.0021), suggesting an association of S100A2 expression and cell commitment to squamous differentiation. A correlation was found between S100A2 tumor positivity and longer relapse-free (P = 0.0005) and overall (P = 0.0095) survival.
Lauriola
L
L
Institute of Pathology, Università Cattolica del S. Cuore, Rome, Italy. ibiap@rm.unicatt.it
Michetti
F
F
Maggiano
N
N
Galli
J
J
Cadoni
G
G
Schäfer
B W
BW
Heizmann
C W
CW
Ranelletti
F O
FO
D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002135:Calcium-Binding Proteins / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002630:Chemotactic Factors / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000096:biosynthesis; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D009367:Neoplasm Staging; D011379:Prognosis; D009418:S100 Proteins / Q000096:biosynthesis*; D016019:Survival Analysis
D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D002630:Chemotactic Factors; D009418:S100 Proteins; C098997:S100A2 protein, human; D007633:Keratins