title: Neonatal thyroid-stimulating hormone screening as an indirect method for the assessment of iodine deficiency in Estonia.
abstract: According to neonatal thyroid screening the incidence of congenital hypothyroidism in Estonia is 1:2,860. Transient hyperthyrotropinemia with a raised thyroid-stimulating hormone level of 5 microU/ml occurred in 17.7% of infants and was not associated with low birth weight, small birth length, low gestational age or congenital anomalies. Based on WHO criteria (WHO/UNICEF, 1994) it corresponds to mild iodine deficiency in Estonia (3% or less is in iodine-sufficient areas). This is in agreement with the previously reported median urinary iodine content of 65 microg/l in children. The frequency of infants with TSH >5 microU/ml was 16.4, 21 and 17. 2% in three regions (north, central and south) of Estonia, respectively, indicating mild to moderate iodine deficiency. These findings show the possibility of using the results of newborn screening for congenital hypothyroidism to assess the severity of iodine deficiency in Estonia. The introduction of universal iodine prophylaxis is recommended.
authors.affiliation: Department of Human Biology and Genetics, Institute of General and Molecular Pathology, University of Tartu, Estonia. mikels@ut.ee
authors.forename: R V
authors.initials: RV
authors.lastname: Mikelsaar
authors.forename: M
authors.initials: M
authors.lastname: Viikmaa
mesh_terms: D003409:Congenital Hypothyroidism; D004957:Estonia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000453:epidemiology; D007231:Infant, Newborn; D007455:Iodine / Q000172:deficiency*; D008297:Male; D015997:Neonatal Screening; D013972:Thyrotropin / Q000097:blood*
chemical_list: D013972:Thyrotropin; D007455:Iodine