[Drug-induced exanthemas].
Drug-induced exanthemas are probably the most frequent cutaneous adverse drug reaction. Outcome of the isolated forms are usually favourable. However, exanthemas may be part of a more severe form, as hypersensitivity syndrome, Lyell syndrome, Stevens-Johnson syndrome or acute generalized exanthematic pustulosis. The mechanism is essentially immunologic. Antibiotics (aminopenicillins, antibacterial sulfamides, antituberculosis drugs) must be considered high risk drugs. Treatment is only symptomatic. Corticosteroids must be avoided.
Chosidow
O
O
Service de médecine interne Groupe hospitalier La Pitié-La Salpêtrière, Paris. olivier.chosidow@psl.ap-hop.paris.fr
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000276:immunology; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000276:immunology / Q000503:physiopathology*; D064420:Drug-Related Side Effects and Adverse Reactions; D005076:Exanthema / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D011379:Prognosis
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents