title: In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs.
abstract: Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, and grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC(90)] 1 microg/ml), although ofloxacin also showed good activity, with an MIC(90) of 2 microg/ml. Trovafloxacin and gemifloxacin showed lower in vitro activity, with MIC(90)s of 64 and 8 microg/ml, respectively.
authors.affiliation: Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario "Gregorio Marañón," Madrid, Spain. mjrfer@microb.net
authors.forename: M J
authors.initials: MJ
authors.lastname: Ruiz-Serrano
authors.forename: L
authors.initials: L
authors.lastname: Alcalá
authors.forename: L
authors.initials: L
authors.lastname: Martínez
authors.forename: M
authors.initials: M
authors.lastname: Díaz
authors.forename: M
authors.initials: M
authors.lastname: Marín
authors.forename: M J
authors.initials: MJ
authors.lastname: González-Abad
authors.forename: E
authors.initials: E
authors.lastname: Bouza
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000502:physiology; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones