Persistent serpentine supravenous hyperpigmented eruption as an adverse reaction to chemotherapy combining actinomycin and vincristine.
A 15-year-old boy experienced a macular serpentine erythematous eruption that subsided with a persistent hyperpigmentation overlying the superficial venous network of the left forearm. This reaction occurred at the injection site of a chemotherapy regimen that combined actinomycin and vincristine a few hours after the first course. After a single injection of actinomycin in the right arm, a similar reaction occurred, implicating it as the responsible agent. A skin biopsy specimen demonstrated a cell-poor interface tissue reaction associated with an eccrine neutrophilic hidradenitis. To our knowledge, this is the first case of persistent supravenous serpentine hyperpigmented eruption reported in a child treated with this particular drug combination.
Marcoux
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Dermatology Division, Department of Pediatrics, Hôpital Sainte-Justine and University of Montreal, Canada.
Anex
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Russo
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D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001132:Arm / Q000473:pathology; D003609:Dactinomycin / Q000008:administration & dosage / Q000009:adverse effects; D003875:Drug Eruptions / Q000473:pathology*; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced*; D008297:Male; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D003609:Dactinomycin; D014750:Vincristine