Complexation and ionophoric properties of taxol and colchicine: complex formation and transport of sodium, potassium, magnesium and calcium ions across a liquid membrane.
We report the activities of taxol (an anticancer drug) and colchicine, which are inhibitors of microtubule organization, on the complexation and transport of Na+, K+, Mg2+ and Ca2+ ions across a liquid membrane, using a spectrophotometric procedure. Taxol, a diterpenoid compound, that has been demonstrated to possess a potent antitumour activity, is shown to extract Na+, K+, Mg2+ and Ca2+ ions from the aqueous solution to the organic phase with preference for Ca2+ ions. A kinetic study of the transport and complexation of Na+, K+, Mg2+ and Ca2+ ions through a liquid membrane revealed that the K+ ion is more rapidly transported and the Ca2+ ion is more rapidly complexed than other ions. However, colchicine, another alkaloid compound, extracted and transported only the divalent ions tested, Mg2+ and Ca2+. In both complexation and transport, the flux of the ions increases with the concentration of taxol or colchicine. Complexation and ionophoric properties of taxol and colchicine sheds new lights on therapeutic properties of these drugs. The treatment of disease states by the administration of these drugs to alter membrane permeability will prove to be a valuable therapeutic concept.
Blaghen
M
M
Unité de Bio-industrie et Toxicologie Moléculaire, Département de Biologie, Université Hassan II, Faculté des Sciences Aïn-Chock, Casablanca, Maroc. blaghen@facsc-achok.ac.ma
Lahlou
N
N
Dzairi
F Z
FZ
Moutaouakkil
A
A
Talbi
M
M
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D003078:Colchicine / Q000378:metabolism / Q000494:pharmacology*; D004573:Electrolytes / Q000378:metabolism*; D017136:Ion Transport / Q000187:drug effects; D007476:Ionophores / Q000494:pharmacology*; D008274:Magnesium / Q000378:metabolism; D008566:Membranes / Q000378:metabolism; D017239:Paclitaxel / Q000378:metabolism / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D004573:Electrolytes; D007476:Ionophores; D012964:Sodium; D008274:Magnesium; D017239:Paclitaxel; D011188:Potassium; D003078:Colchicine; D002118:Calcium