title: Near full-length genome analysis of HIV type 1 CRF02.AG subtype C and CRF02.AG subtype G recombinants.
abstract: HIV-1 CRF02.AG strains are prevalent in west and west-central Africa, suggesting a longstanding presence of these subtype A/G recombinants in the global epidemic. Cocirculation of CRF02.AG strains with other group M subtypes may give rise to HIV-1 recombinants constituting a mosaic genome comprising fragments of three different subtypes. We report on the genetic analysis of the near-full-length genomes of such recombinants (VI1035 and VI1197) as well as CRF02.AG strains in Belgian individuals. VI1035 and VI1197 may be the result of successful "second-generation" recombinations of HIV-1 strains CRF02.AG with, respectively, subtype C (VI1035) and G (VI1197) strains in a dually infected individual.
authors.affiliation: Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium. wjanssens@itg.be
authors.forename: W
authors.initials: W
authors.lastname: Janssens
authors.forename: M O
authors.initials: MO
authors.lastname: Salminen
authors.forename: T
authors.initials: T
authors.lastname: Laukkanen
authors.forename: L
authors.initials: L
authors.lastname: Heyndrickx
authors.lastname: van der Auwera
authors.forename: R
authors.initials: R
authors.lastname: Colebunders
authors.forename: F E
authors.initials: FE
authors.lastname: McCutchan
authors.forename: G
authors.initials: G
authors.lastname: van der Groen
mesh_terms: D000350:Africa, Central; D000354:Africa, Western; D001530:Belgium; D016679:Genome, Viral; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D010802:Phylogeny; D011995:Recombination, Genetic; D016415:Sequence Alignment