title: Angioendotheliomatosis in a woman with rheumatoid arthritis.
abstract: Reactive angioendotheliomatosis (RA) is a rare self-limited skin condition characterized histopathologically by a proliferation of endothelial cells within vascular lumina, usually as a result of different stimuli such as systemic infections, cryoproteinemias, monoclonal gammopathies, allergic conditions, severe peripheral vascular atherosclerotic disease, and iatrogenic arteriovenous fistulas. We report on a 67-year-old woman with a 20-year history of seropositive rheumatoid arthritis who presented with violaceous swelling of her left forearm. A skin biopsy revealed the histopathologic finding of RA with focal glomeruloid features and deposition of periodic acid-Schiff-positive material. In this systemic disorder, cutaneous manifestations may occur secondary to an immune complex-mediated vasculitic mechanism.
authors.affiliation: Department of Medical and Surgical Specialties, Second Dermatologic Clinic, Turin, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Tomasini
authors.forename: E
authors.initials: E
authors.lastname: Soro
authors.forename: M
authors.initials: M
authors.lastname: Pippione
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008228:Lymphoma, Non-Hodgkin / Q000737:chemistry / Q000209:etiology* / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000209:etiology* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins