title: Primary diffuse leptomeningeal gliomatosis: unusual MRI with non-enhancing nodular lesions on the cerebellar surface and spinal leptomeningeal enhancement.
abstract: A 28 year old man presented with a 1 month history of symptoms of intracranial hypertension. Examination showed bilateral papilloedema and meningeal signs. Magnetic resonance imaging showed nodular lesions on the cerebellar and pontine surface and thickening of the thoracic spinal leptomeninges. Throughout the course of the disease, contrast enhancement was detected in the spinal leptomeninges but not intracranially. Primary diffuse leptomeningeal gliomatosis (PDLG) was diagnosed by biopsy and later confirmed on necropsy. The present case is remarkable for the nodular superficial cerebellar lesions and the absence of intracranial contrast enhancement of the leptomeninges.
authors.affiliation: Department of Neurology, Ludwig-Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Kastenbauer
authors.forename: A
authors.initials: A
authors.lastname: Danek
authors.forename: W
authors.initials: W
authors.lastname: Klein
authors.forename: T A
authors.initials: TA
authors.lastname: Yousry
authors.forename: K
authors.initials: K
authors.lastname: Bise
authors.forename: G
authors.initials: G
authors.lastname: Reifenberger
authors.forename: H W
authors.initials: HW
authors.lastname: Pfister
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000473:pathology*; D005682:Gadolinium; D005910:Glioma / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*
chemical_list: D005682:Gadolinium