title: Phsyiological relevance of aquaporins: luxury or necessity?
abstract: Aquaporins are members of a large family of pore-forming intrinsic membrane proteins, the MIP family. Based on their permeability properties they are now further subdivided into aquaporins, with real water-selective pores, and aquaglyceroporins with slightly less selective pores. Aquaporins are expressed in a large variety of tissues throughout the body but in most situations it is not clear whether their presence is necessary for the proper physiological function of these tissues. This review focuses on recent insight into the physiological relevance of aquaporins gained from studying aquaporin knockout mouse models and from diseases, on new surprising findings related to gating and selectivity, and on the consequences of tetramerization for routing and the genetics of nephrogenic diabetes insipidus. The active fluid transport in proximal tubules and in salivary glands is seriously compromised by aquaporin deletion. This is in contrast to lung, airways and stomach, where active fluid transport proceeds unhindered in the face of greatly reduced water permeabilities due to aquaporin deletion. Therefore, aquaporins seem to be a necessity at extreme high rates of active fluid transport but appear to be more of a luxury at medium or low fluid transport rates.
authors.affiliation: Department of Cell Physiology, University Medical Center, University of Nijmegen, The Netherlands. C.vanOs@celfys.kun.nl
authors.forename: C H
authors.initials: CH
authors.lastname: van Os
authors.forename: E J
authors.initials: EJ
authors.lastname: Kamsteeg
authors.forename: N
authors.initials: N
authors.lastname: Marr
authors.forename: P M
authors.initials: PM
authors.lastname: Deen
mesh_terms: D000818:Animals; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D002463:Cell Membrane Permeability; D018500:Diabetes Insipidus, Nephrogenic / Q000235:genetics / Q000378:metabolism; D006801:Humans; D015640:Ion Channel Gating; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009928:Organ Specificity
chemical_list: C496023:AQP2 protein, human; C496024:Aqp2 protein, mouse; C496042:Aqp6 protein, mouse; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins