Effect of monoterpene derivative KP-19 on the pressor activity of catecholamines in rats.
The present study investigated the influence of KP-19, the propranolol analogue, bearing natural monoterpene moiety in its structure, on the blood pressure and respiration, the effect on the isolated heart rhythm disturbances induced by occlusion and reperfusion and on the pressor activity of catecholamines in normotensive rats.
Librowski
T
T
Department of Pharmacodynamics, Collegium Medicum, Jagiellonian University, Kraków, Poland. mflibrow@kinga.cyf-kr.edu.pl
Czarnecki
R
R
Jastrzebska
M
M
Sapa
J
J
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000503:physiopathology; D000081008:Bicyclic Monoterpenes; D001794:Blood Pressure / Q000187:drug effects*; D002395:Catecholamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D039821:Monoterpenes; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000503:physiopathology; D011433:Propranolol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000494:pharmacology*
D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D000081008:Bicyclic Monoterpenes; D002395:Catecholamines; C418766:KP19 terpene; D039821:Monoterpenes; D013729:Terpenes; D011433:Propranolol