title: Evolution of odorant receptors.
abstract: Odorant receptors (ORs) located in the nasal epithelium, at the ciliated surface of olfactory sensory neurons, represent the initial step of a transduction cascade that leads to odor detection. ORs form the largest and most diverse family of G-protein-coupled receptors (GPCRs). They are encoded by a multigene family that has been partially characterized in cyclostomes, teleosts, amphibia, birds and mammals, as well as in Drosophila melanogaster and the nematode Caenorhabditis elegans. As new sequence data emerge, it is increasingly clear that OR primary structure can vary dramatically across phyla. Some chemoreceptors are encoded by genes with little sequence similarity to the prototypical ORs originally isolated in mammals. A large number of sequences are now available allowing a detailed study of the evolutionary implications of OR diversity across species. This review discusses the evolutionary implications of the divergent primary structures of chemoreceptors with identical functions.
authors.affiliation: Department of Biology and Biochemistry, University of Houston, Houston, TX 77204-5513, USA. Idryer@bayou.uh.edu
authors.forename: L
authors.initials: L
authors.lastname: Dryer
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D018035:Receptors, Odorant / Q000235:genetics*; D017421:Sequence Analysis; D015398:Signal Transduction / Q000235:genetics
chemical_list: D018035:Receptors, Odorant