[Oxidative determination of hydroxyamphetamine in drops using flow injection analysis].
A flow injection-spectrophotometric determination at 540 nm of hydroxyamphetamine is reported. The procedure is based on a coloured reaction with 2-hydrazono-3-methylbenzothiazole (MBTH) and ceric ammonium nitrate (CeIV) as the oxidation reagent. Under optimised conditions, the determination of hydroxyamphetamine is achieved in a range of 0.01-0.2 mmol.l-1 with a relative standard deviation of 0.78% for 0.05 mmol.l-1 (n = 10) and a sample throughput of 75.h-1. The method was used for the determination of medicinal drug in the mass-produced dosage form of Czech origin: Pedrolon drops, Galena a.c.
Dolejsová
J
J
Katedra analytické chemie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
Karlícek
R
R
Pospísilová
M
M
D017022:Flow Injection Analysis / Q000379:methods*; D016877:Oxidants; D019999:Pharmaceutical Solutions / Q000737:chemistry*; D010136:p-Hydroxyamphetamine / Q000032:analysis*
D016877:Oxidants; D019999:Pharmaceutical Solutions; D010136:p-Hydroxyamphetamine