Use of saliva specimens for monitoring indinavir therapy in human immunodeficiency virus-infected patients.
Indinavir concentrations were determined in plasma and saliva over a random period of 4 h. On average, levels in saliva were 70% +/- 38% of the corresponding levels in plasma. These findings suggest that saliva might serve as an appropriate specimen for monitoring of plasma indinavir levels in patients treated with indinavir.
Wintergerst
U
U
Department of Infectious Diseases and Immunology, Federal Republic of Germany. uwe.wintergerst@KK-i.med.uni-muenchen.de
Kurowski
M
M
Rolinski
B
B
Müller
M
M
Wolf
E
E
Jaeger
H
H
Belohradsky
B H
BH
D000328:Adult; D016903:Drug Monitoring; D005240:Feasibility Studies; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D019469:Indinavir / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D008297:Male; D012463:Saliva / Q000378:metabolism*
D017320:HIV Protease Inhibitors; D019469:Indinavir