Image analysis of mesothelioma. II. Discrimination of mesothelioma from metastatic serous ovarian adenocarcinoma.
OBJECTIVE
To examine the utility of karyometric measurements in the differentiation of mesothelioma from metastatic serous ovarian adenocarcinoma.


METHODS
High-resolution images of 1,631 nuclei from 32 cases of mesothelioma and 742 nuclei from 15 cases of ovarian adenocarcinoma were recorded. A stepwise discriminant analysis and nonparametric classifier were applied.


RESULTS
Nuclei from these two diagnostic categories appear very similar and occupy feature space with significant overlap. A nonparametric classification procedure provided acceptable correct classification.


CONCLUSIONS
For certain regions in feature space, cases could be unequivocally classified.
Protopapa
E
E
Department of Pathology, Metaxa Cancer Institute, Piraeus, Greece.
Delides
G
G
Miaoulis
G
G
Thompson
D
D
Bartels
P H
PH
D002467:Cell Nucleus / Q000648:ultrastructure; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis* / Q000235:genetics; D004273:DNA, Neoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007620:Karyometry; D008654:Mesothelioma / Q000175:diagnosis* / Q000235:genetics; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000235:genetics; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000235:genetics
D004273:DNA, Neoplasm