Physiopathology of the renin-angiotensin system in the ovary.
The present review confirms the existence of the so-called "ovarian-derived prorenin-angiotensin cascade". It also describes the physiopathology of the system and, consequently, its role in the genesis of phenomena concerning reproductive function such as ovulation, steroid synthesis and folliculogenesis. Moreover, the "ovarian-derived prorenin-angiotensin cascade" appears to play an important role in the aetiopathogenesis of diseases such as ovarian tumours, ovarian hyperstimulation syndrome and ectopic pregnancy.
De Nuccio
I
I
Department of Medical Physiopathology, University of Rome La Sapienza.
Salvati
G
G
Genovesi
G
G
Paolini
P
P
Marcellini
L
L
Schiavello
V
V
Re
M
M
D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000502:physiology; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology; D010049:Ovarian Diseases / Q000209:etiology / Q000503:physiopathology*; D016471:Ovarian Hyperstimulation Syndrome / Q000209:etiology / Q000503:physiopathology; D010051:Ovarian Neoplasms / Q000209:etiology; D010053:Ovary / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D010060:Ovulation / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000209:etiology; D011817:Rabbits; D012083:Renin / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*; D010959:Tissue Plasminogen Activator / Q000502:physiology
D004792:Enzyme Precursors; D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D010959:Tissue Plasminogen Activator; D003546:Cysteine Endopeptidases; C063281:prorenin processing enzyme; D012083:Renin