Central thermoregulatory effects of neuropeptide Y and orexin A in rats.
Orexin A and neuropeptide Y that are known to induce a feeding response when applied centrally, in the present studies also caused hypothermia. Neuropeptide Y elicited hypothermia by depressing metabolic rate (without affecting heat loss mechanisms), while orexin A acted through enhancing peripheral heat loss (without affecting metabolic rate). Neither peptide induced coordinated thermoregulatory changes, both of them appeared to influence thermoregulation via different effector mechanisms.
Balaskó
M
M
Department of Pathophysiology, University Medical School, Pecs, Hungary.
Szelényi
Z
Z
Székely
M
M
D000222:Adaptation, Physiological; D000818:Animals; D019167:Appetite Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D002352:Carrier Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007276:Injections, Intraventricular; D047908:Intracellular Signaling Peptides and Proteins; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology*; D000068797:Orexins; D051381:Rats; D017208:Rats, Wistar
D019167:Appetite Stimulants; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009478:Neuropeptide Y; D009479:Neuropeptides; D000068797:Orexins