title: High-altitude cerebral edema (HACE): the Denver/Front Range experience.
abstract: High-altitude cerebral edema (HACE) is a potentially fatal metabolic encephalopathy associated with a time-dependent exposure to the hypobaric hypoxia of altitude. Symptoms commonly are headache, ataxia, and confusion progressing to stupor and coma. HACE is often preceded by symptoms of acute mountain sickness and coupled, in its severe form, with high-altitude pulmonary edema. Although HACE is mostly seen at altitudes above that of the Denver/Front Range visitor-skier locations, we report our observations over a 13-year period of skier-visitor HACE patients. It is believed that this is a form of vasogenic edema, and it is responsive to expeditious treatment with a successful outcome.
authors.affiliation: Department of Neurology, University of Colorado School of Medicine, St. Anthony's Hospital Denver, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Yarnell
authors.forename: J
authors.initials: J
authors.lastname: Heit
authors.forename: P H
authors.initials: PH
authors.lastname: Hackett
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000532:Altitude Sickness / Q000150:complications* / Q000503:physiopathology* / Q000628:therapy; D001929:Brain Edema / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009051:Mountaineering / Q000293:injuries* / Q000502:physiology*; D011654:Pulmonary Edema / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012166:Retinal Hemorrhage / Q000209:etiology / Q000473:pathology / Q000503:physiopathology