title: Circulating interleukin-6 and interleukin-6 receptors in patients with acute and recent myocardial infarction.
abstract: Interleukin-6 (IL-6), a proinflammatory cytokine, plays a key role in the pathogenesis of coronary artery disease (CAD). We investigated circulating IL-6 and its receptors in patients with CAD. We evaluated 39 Japanese patients with CAD (30 males and 9 females aged 36-79 years), measuring their plasma levels of IL-6 and IL-6 receptors alpha and beta (IL-6R alpha, IL-6R beta). Circulating levels of IL-6, IL-6R alpha and IL-6R beta were measured by an enzyme-linked immunosorbent assay. Blood was sampled immediately after admission and again after 1, 2, 3, 6 and 9 h, then every 12 h for 5 days. Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) were measured on day 3 after symptom onset. Plasma levels of IL-6 and IL-6Rs were significantly increased in 28 patients with acute myocardial infarction (AMI) compared with 15 normal controls. However, neither IL-6 nor IL-6Rs showed an increase in 6 patients with angina pectoris. We observed two peaks for circulating IL-6 in AMI, the first of which showed a significant correlation with ANP as well as BNP. These results may help to explain why the amount of IL-6 produced is closely related to the severity of myocardial dysfunction in patients with CAD.
authors.affiliation: Department of General Medicine, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kanda
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Kotajima
authors.forename: S
authors.initials: S
authors.lastname: Fujimaki
authors.forename: Y
authors.initials: Y
authors.lastname: Hoshino
authors.forename: M
authors.initials: M
authors.lastname: Kurabayashi
authors.forename: I
authors.initials: I
authors.lastname: Kobayashi
authors.forename: J
authors.initials: J
authors.lastname: Tamura
mesh_terms: D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood; D015415:Biomarkers / Q000097:blood; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011379:Prognosis; D011863:Radioimmunoassay; D019947:Receptors, Interleukin-6 / Q000097:blood*; D012720:Severity of Illness Index; D013318:Stroke Volume
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D019947:Receptors, Interleukin-6; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor