title: Metabolism of O6-propyl and N6-propyl-carbovir in CEM cells.
abstract: The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'-triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3-nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.
authors.affiliation: Southern Research Institute, Birmingham, AL 35205, USA.
authors.forename: W B
authors.initials: WB
authors.lastname: Parker
authors.forename: S C
authors.initials: SC
authors.lastname: Shaddix
authors.forename: L M
authors.initials: LM
authors.lastname: Rose
authors.forename: P T
authors.initials: PT
authors.lastname: Pham
authors.forename: M
authors.initials: M
authors.lastname: Hua
authors.forename: R
authors.initials: R
authors.lastname: Vince
mesh_terms: D000478:Alkylation; D019380:Anti-HIV Agents / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000378:metabolism*; D002460:Cell Line / Q000378:metabolism*; D015224:Dideoxynucleosides / Q000037:antagonists & inhibitors / Q000138:chemical synthesis / Q000378:metabolism*; D015497:HIV-1 / Q000187:drug effects / Q000378:metabolism; D009173:Mycophenolic Acid / Q000494:pharmacology; D015649:Pentostatin / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; C057503:carbovir; D015649:Pentostatin; D009173:Mycophenolic Acid