Angiogenesis in metastatic verrucous carcinoma of the uterine cervix.
A 65-year old woman operated on for verrucous carcinoma of the uterine cervix 13 years previously was found to have multiple small recurrent tumors in the retroperitoneal space. Tumor cell expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) was investigated at the second operation. Expression of VEGF was strongly positive in the tumor cells and expression of PD-ECGF was strongly positive in both the tumor cells and the interstitial cells.
Matsumoto
Y
Y
Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka 545-8585, Japan.
Ishiko
O
O
Nishimura
S
S
Ogita
S
S
Kubota
K
K
Haba
T
T
Wakasa
K
K
D000368:Aged; D018289:Carcinoma, Verrucous / Q000098:blood supply* / Q000378:metabolism / Q000556:secondary*; D016228:Endothelial Growth Factors / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008222:Lymphokines / Q000096:biosynthesis; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D012186:Retroperitoneal Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000556:secondary*; D013939:Thymidine Phosphorylase / Q000096:biosynthesis; D002583:Uterine Cervical Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013939:Thymidine Phosphorylase