Endovascular stents and stent-grafts: is heparin coating desirable?
Heparins are glycosaminoglycans that, in addition to their anticoagulant activity, have interactions with growth factors and other glycoproteins. These interactions may stimulate neointimal hyperplasia when heparin is delivered locally on stents and stent-grafts. Modifying the structure of heparin to retain anticoagulant activity while minimizing these stimulatory effects on the vascular endothelium is desirable and may be achieved by understanding the relationships between the structure and function of the various parts of the heparin molecule.
Nelson
S R
SR
Department of Renal Medicine, St. George's Hospital, Blackshaw Road, London SW17 0QT, UK.
deSouza
N M
NM
Allison
D J
DJ
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation*; D002455:Cell Division / Q000187:drug effects; D020099:Coated Materials, Biocompatible; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D005346:Fibroblast Growth Factors / Q000187:drug effects / Q000378:metabolism; D006083:Graft Occlusion, Vascular / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D006085:Graft Survival; D006493:Heparin / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design; D015607:Stents
D000925:Anticoagulants; D020099:Coated Materials, Biocompatible; D011093:Polyethylene Terephthalates; D005346:Fibroblast Growth Factors; D006493:Heparin