title: No effect of preoperative paracetamol and codeine suppositories for pain after termination of pregnancies in general anaesthesia.
abstract: Outpatient surgery demands rapid recovery and satisfied patients. The purpose of the study was to investigate whether rectal premedication with paracetamol and codeine would reduce the need of rescue analgesics, reduce the postoperative pain experience and result in faster eligibility for discharge. Ninety pregnant patients scheduled for day-case surgery with evacuation of the uterine cavity were randomly assigned into two groups. The paracetamol and codeine group was given a suppository with 60 mg of codeine and 800 mg of paracetamol together with standard premedication of intramuscular midazolam 0.08 mg/kg. The placebo group was given a placebo suppository and midazolam. All patients underwent the surgical procedure under general anaesthesia with alfentanil 15 microg/kg and propofol 1.5-2 mg/kg. There were no statistically significant differences between the groups in the postoperative pain experience as judged by Visual Analogue Scale (VAS-scale), verbal scale or the need for rescue analgesic medication with ketobemidone. Most of the patients experienced little postoperative pain with more than 70% scoring less than 20 mm on a VAS-scale from 0-100 mm at any time during the postoperative period. The paracetamol and codeine patients were significantly more sleepy at 30 min postoperatively. There were no differences between the groups in postoperative nausea or vomiting and no difference in discharge eligibility. The use of pre-operative suppository with paracetamol 800 mg and codeine 60 mg is unnecessary in this group of patients.
authors.affiliation: Department of Anaesthesia, Baerum Hospital, Baerum Post, Norway. vdahl@ah.telia.no
authors.forename: V
authors.initials: V
authors.lastname: Dahl
authors.forename: F
authors.initials: F
authors.lastname: Fjellanger
authors.forename: J C
authors.initials: JC
authors.lastname: Raeder
mesh_terms: D000028:Abortion, Induced; D000082:Acetaminophen / Q000008:administration & dosage*; D000328:Adult; D015760:Alfentanil; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D003061:Codeine / Q000008:administration & dosage*; D004107:Dilatation and Curettage; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008874:Midazolam; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011247:Pregnancy; D015742:Propofol; D013488:Suppositories
chemical_list: D018712:Analgesics, Non-Narcotic; D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D013488:Suppositories; D015760:Alfentanil; D000082:Acetaminophen; D008874:Midazolam; D003061:Codeine; D015742:Propofol