title: Dengue viral infections; pathogenesis and epidemiology.
abstract: Dengue viral infections affect up to 100 million individuals per year. Dengue haemorrhagic fever is a clinical form of disease characterised by intravascular fluid loss. There has been a marked increase in the incidence of this form of the disease over the last few decades, associated with significant mortality, particularly in the paediatric population. A number of theories relating to the pathogenesis of dengue haemorrhagic fever exist that have evolved from the analysis of the epidemiology of this disease. Virological and immunopathological factors are both important but the exact mechanisms for the disease are unknown.
authors.affiliation: Department of Pathology, Cairns Base Hospital, The Esplanade, Cairns, Queensland 4870, Australia. mcbrij@health.qqld.gov.au
authors.forename: W J
authors.initials: WJ
authors.lastname: McBride
authors.forename: H
authors.initials: H
authors.lastname: Bielefeldt-Ohmann
mesh_terms: D000349:Africa; D001208:Asia; D002489:Central America; D002648:Child; D003715:Dengue / Q000453:epidemiology* / Q000821:virology*; D003716:Dengue Virus / Q000472:pathogenicity*; D006801:Humans; D010139:Pacific Islands; D011991:Receptors, Virus / Q000032:analysis; D013020:South America; D014774:Virulence; D014779:Virus Replication; D014900:West Indies
chemical_list: D011991:Receptors, Virus