title: [Abnormality of blood congulation].
abstract: Obstructive Sleep Apnea(OSA) is associated with an increased prevalence of cardiovascular complication such as systemic hypertension, ischemic heart disease and stroke, which may lead to unexpected or early death. Sleep in patients with OSA demonstrates a pattern of recurrent arousals, hemodynamic changes, and sympathetic neural activity that have been associated with adverse carviovascular events following awakening in the morning. Neurologic problems in patients with OSA include cognitive impairment, poor memory, and high risk for cerebral infarction. These central nervous system symptoms might be due to hypoxemia and sleep fragmentations. The vascular endothelial damage, platelet aggregation, and hemodynamic changes during sleep apnea are influenced by changes in oxygen and carbon dioxide tension inducing alterations of vascular tone. The cerebral hemodynamics in relation to apneas may not only influence daytime cerebral symptoms but may also have implications for the generation of cerebrovascular disease in OSA. These changes resulted from OSA might play an important role in pathophysiological aspects of the central nervous system. And these changes will be improved after CPAP application.
authors.affiliation: Tokai University School of Medicine, Dept. Pulmonary Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Ohta
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology; D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D010974:Platelet Aggregation; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications; D012894:Sleep Stages / Q000502:physiology