title: Implication of interleukin-4 in wound healing.
abstract: Interleukin-4 (IL-4) is a pleiotropic cytokine that is able to activate connective tissue cells and stimulate the accumulation of extracellular matrix macromolecules. In this report, the expression of IL-4 in normal wound healing was studied by immunohistochemistry. The effects of exogenous IL-4 or IL-4 antisense oligonucleotides administration were also studied in mouse experimental wounds. IL-4 expression was detected in the lower dermis below the wound as early as Day 1 after wounding. IL-4 expression was maximal by Day 4, then decreased progressively, and completely disappeared by Day 21 after wounding. Topical administration of IL-4 on experimental wounds in mice significantly accelerated the rate of healing, whereas IL-4 antisense oligonucleotides significantly inhibited healing. These results demonstrate that IL-4 may be implicated in normal wound healing.
authors.affiliation: Laboratoire de Biochimie et Biologie Moléculaire, Faculté de Médecine, Reims, France.
authors.forename: V
authors.initials: V
authors.lastname: Salmon-Ehr
authors.forename: L
authors.initials: L
authors.lastname: Ramont
authors.forename: G
authors.initials: G
authors.lastname: Godeau
authors.forename: P
authors.initials: P
authors.lastname: Birembaut
authors.forename: M
authors.initials: M
authors.lastname: Guenounou
authors.forename: P
authors.initials: P
authors.lastname: Bernard
authors.forename: F X
authors.initials: FX
authors.lastname: Maquart
mesh_terms: D000818:Animals; D001483:Base Sequence; D015847:Interleukin-4 / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology*; D051379:Mice; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D016376:Oligonucleotides, Antisense; D015847:Interleukin-4