title: Heparan sulphate. Regulation of growth factors in the mammary gland.
abstract: Heparan sulphate (HS) is a linear glycosaminoglycan found ubiquitously on the surface and in the pericellular matrix of metazoan cells that is covalently attached to core proteins to form HS proteoglycans. HS interacts specifically with a large number (> 100) of extracellular regulatory proteins, many of which are key players in mammary development and function. HS thus acts a receptor, in which capacity it regulates the bioavailability, localisation and activity of these regulatory proteins.
authors.affiliation: School of Biological Sciences, University of Liverpool, UK.
authors.forename: K L
authors.initials: KL
authors.lastname: Bateman
authors.forename: M
authors.initials: M
authors.lastname: Delehedde
authors.forename: N
authors.initials: N
authors.lastname: Sergeant
authors.forename: I
authors.initials: I
authors.lastname: Wartelle
authors.forename: R
authors.initials: R
authors.lastname: Vidyasagar
authors.forename: D G
authors.initials: DG
authors.lastname: Fernig
mesh_terms: D000818:Animals; D001940:Breast / Q000378:metabolism*; D005260:Female; D006133:Growth Substances / Q000378:metabolism*; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D008321:Mammary Glands, Animal / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D006133:Growth Substances; D006497:Heparan Sulfate; D011956:Receptors, Cell Surface