[Decreased activity of 11-beta-hydroxysteroid dehydrogenase in patients with Cushing's syndrome].
BACKGROUND
To study 11 beta-hydroxysteroid dehydrogenase activity in Cushing's syndrome.


METHODS
Measurements of free cortisol, cortisone, tetrahydrocortisol and tetrahydrocortisone in 24 h urine samples of patients with Cushing's syndrome and controls.


RESULTS
The cortisol to cortisone and tetrahydrocortisol to tetrahydrocortisone relationship was significant (in controls, r = 0.70; p < 0.0001, and r = 0.75; p < 0.0001) respectively, but it was not in patients with Cushing's syndrome.


CONCLUSIONS
11 beta-hydroxysteroid dehydrogenase activity is decreased in patients with Cushing's syndrome.
Stiefel
P
P
Servicio de Medicina Interna, Hospitales Universitarios Virgen del Rocío, Sevilla. stiefel@cica.es
Jiménez
L
L
García-Morillo
J S
JS
Leal
A
A
Villar
J
J
Carneado
J
J
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003348:Cortisone / Q000652:urine; D003480:Cushing Syndrome / Q000175:diagnosis / Q000201:enzymology* / Q000652:urine; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D015592:Immunoradiometric Assay; D008163:Luminescent Measurements; D008297:Male; D013760:Tetrahydrocortisol / Q000652:urine; D013761:Tetrahydrocortisone / Q000652:urine
D013761:Tetrahydrocortisone; D013760:Tetrahydrocortisol; D000324:Adrenocorticotropic Hormone; D006913:Hydroxysteroid Dehydrogenases; D003348:Cortisone; D006854:Hydrocortisone