[The study of polymorphism of dopamine D2 receptor gene in men from different ethnic groups with acute alcoholic psychosis].
The polymerase chain reaction of DNA synthesis was used to analyze the polymorphism of TaqI A and NcoI loci of dopamine D2 receptor gene (DRD2) in 170 Tatar and Russian males with acute alcoholic psychosis. No differences were found in the distribution of frequencies of genotypes and alleles of DRD2 gene between the populations. There were differences in the distribution of the frequencies of genotypes of the locus TaqI A and haplotypes of the gene DRD2 were revealed between patients and controls of the same nationality; moreover these differences were significant in the Russians. The findings suggest that alcoholics show a selection aimed at eliminating individuals with haplotypes who carry Al and N2 alleles and who are homozygous by one of these alleles. This may account for a decrease in the frequency of locus TaqI A genotypes carrying A1 allele, primarily A1/A1 homozygotes and for the loss of haplotypes of TaqI A and NcoI loci of the gene DRD2 -A1N1N2, A1A2N2 in men with acute alcoholic psychosis as compared with the controls.
Galeeva
A R
AR
Iur'ev
E B
EB
Valinurova
I R
IR
Khusnytdinova
E K
EK
D000208:Acute Disease; D000437:Alcoholism / Q000150:complications* / Q000235:genetics*; D000483:Alleles; D005006:Ethnicity / Q000523:psychology*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D011618:Psychotic Disorders / Q000209:etiology*; D017448:Receptors, Dopamine D2 / Q000235:genetics* / Q000378:metabolism*
D017448:Receptors, Dopamine D2