Behavioural activity of (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors.
The influence of intracerebroventricular (i.c.v.) injections of (S)-3,5-dihydroxyphenyl-glycine (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (mGluRs), on the activity of the central nervous system was examined in male rats. (S)-3,5-DHPG at doses of 25, 50 and 100 nmol significantly attenuated crossings of squares and rearings, but not bar approaches, in an 'open field' test and failed to change apomorphine-induced stereotypy. (S)-3,5-DHPG at the above doses, given immediately after the learning trial, significantly facilitated the consolidation process in a passive avoidance situation, but given before the learning trial and before the retention testing did not have any influence on acquisition and retrieval processes, respectively. Moreover, (S)-3,5-DHPG did not influence recognition memory evaluated in an object recognition test. These results may suggest that activation of group I mGluRs takes part in the consolidation process in affectively-motivated memory, but is probably not necessary for processing of recognition memory, and that (S)-3,5-DHPG memory facilitation seems to be independent of glutamatergic and dopaminergic interaction.
Zalewska-Wińska
A
A
Department of Pharmacology, Medical University, Mickiewicza 2c, 15-222 Białystok, Poland.
Wiśniewski
K
K
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000502:physiology*; D012118:Resorcinols / Q000494:pharmacology*
D018094:Receptors, Metabotropic Glutamate; D012118:Resorcinols; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; C079215:3,5-dihydroxyphenylglycine; D001058:Apomorphine; D005998:Glycine