Acute glomerulonephritis.
Acute glomerulonephritis (AGN) is a representative disease of acute nephritic syndrome characterized by the sudden appearance of edema, hematuria, proteinuria, and hypertension. The prototype of AGN is acute poststreptococcal glomerulonephritis (APSGN). "Nephritogenic streptococci" are defined as organisms that are cultured from a patient who develops AGN. Although only a limited number of M-types of streptococci have been recognized as "nephritogenic streptococci", all M-types of streptococci may have nephritogenic potential because the genes for major putative nephritogenic antigens such as SPEB and NAPIr are found to be present in all group A streptococci thus far examined. Pathogenic mechanisms for APSGN involving both humoral and cell-mediated immunity have been recently proposed. The role of humoral immunity is presumed to be mediated by the in situ formation of nephritogenic streptococcal antigen-antibody complexes and circulating immune complexes. While in the cellular immune component a role for delayed-type hypersensitivity has been suggested to contribute to the pathogenesis of APSGN.
Yoshizawa
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Department of Public Health, National Defense Medical College, Saitama.
D000208:Acute Disease; D000595:Amino Acid Sequence; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D003546:Cysteine Endopeptidases / Q000276:immunology; D005921:Glomerulonephritis / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008969:Molecular Sequence Data; D018000:Receptors, Peptide / Q000737:chemistry; D013290:Streptococcal Infections / Q000150:complications / Q000276:immunology; D013291:Streptococcus / Q000276:immunology
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D018000:Receptors, Peptide; C042387:nephritis-strain associated protein, group A Streptococcus; C065181:plasmin receptor; D003546:Cysteine Endopeptidases; C042477:streptopain