The total synthesis of piclavines A1-4 and their biological evaluation.
The total synthesis of piclavines A1, A2, A3, and A4 has been achieved starting from compound 10 with enantiomeric enhancement. Their biological activities (antibacterial, antimicrobacterial, and antiviral activities and inhibition of cell growth) were evaluated.
Takahata
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H
Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Sugitani, Japan. takahata@ms.toyama-mpu.ac.jp
Okamoto
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N
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002522:Chlorocebus aethiops; D004353:Drug Evaluation, Preclinical; D004876:Ergot Alkaloids; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007668:Kidney; D008968:Molecular Conformation; D015394:Molecular Structure; D013296:Streptococcus pneumoniae / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D004876:Ergot Alkaloids; D007212:Indolizines