Mobilization of mercury by DMPS in occupationally exposed workers and in model experiments on rats: evaluation of body burden.
The aim of the study was to evaluate the efficacy of DMPS (sodium-2,3-dimercapto-1-propane sulfonate) (Dimaval) administration for mobilizing mercury from the body in occupationally exposed people and experimental animals. Two doses of DMPS were administered at a 24-h interval to: (a) groups of people occupationally exposed to merkury--workers of the chloralkali industry (n = 43), and dentists (n = 12), (b) non-exposed individuals (n = 20), and (c) rats chronically exposed to mercury vapour at the concentration of 0.8 mg/m3 Hg degree (6 h/day, 5 days/week) for 15 weeks. In an out-patient mobilizing test, the urinary excretion of mercury 48 h after the administration of the first dose reached 1513 micrograms in the group of industrial workers, 132.6 micrograms in dentists, and 3.78 micrograms in controls. In rats, two consecutive doses of DMPS decreased kidney content of mercury by about 30% and 50% after oral and intraperitoneal administration, respectively. Kidney mercury burden was calculated on the basis of the data from animal and human studies of the mobilization of mercury via urine after DMPS treatment: 61, 2800 and 28,000 ng/g in controls, dentists and workers, respectively. It was estimated that two doses of DMPS mobilized 17-20% (after oral administration) and 25-30% (after intramuscular administration) of kidney mercury burden, both in the control and exposed subjects.
Nerudová
J
J
Centre of Industrial Health and Occupational Diseases, National Institute of Public Health, Prague, Czech Republic.
Cábelková
Z
Z
Frantík
E
E
Lukás
E
E
Urban
P
P
Bláha
K
K
Pelclová
D
D
Lebedová
J
J
Cikrt
M
M
D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D001822:Body Burden; D016022:Case-Control Studies; D002614:Chelating Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008630:Mercury Poisoning / Q000188:drug therapy* / Q000378:metabolism; D008875:Middle Aged; D009784:Occupational Diseases / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014494:Unithiol / Q000627:therapeutic use*
D002614:Chelating Agents; D014494:Unithiol