Microbiology. A weak link in TB bacterium is found.
The secret of the success of Mycobacterium tuberculosis, the pathogen that causes tuberculosis, is that it can linger undetected in the lungs for decades, hiding from the immune system's macrophages that aim to chew it up and spit it out. Now a team of researchers has uncovered a vulnerability in this resilient bug that suggests new ways to starve it out of its bolt-hole.
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D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006038:Glyoxylates / Q000378:metabolism; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D014376:Tuberculosis / Q000188:drug therapy / Q000382:microbiology*
D000995:Antitubercular Agents; D004791:Enzyme Inhibitors; D006038:Glyoxylates; D007522:Isocitrate Lyase; C031150:glyoxylic acid