CD1-restricted T-cell responses and microbial infection.
CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC-peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.
Park
S H
SH
Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
Bendelac
A
A
D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D006801:Humans; D007239:Infections / Q000276:immunology* / Q000382:microbiology; D007694:Killer Cells, Natural / Q000276:immunology; D008055:Lipids / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014612:Vaccines / Q000276:immunology
D018949:Antigens, CD1; D008055:Lipids; D014612:Vaccines