Growth in four patients on combined treatment with LHRH analogue and growth hormone after renal transplantation.
Four short pubertal boys were treated with LHRHa (leuprolide) and GH after renal transplantation, and followed until adult height. This combined therapy was not successful in increasing growth. Although this study must be considered preliminary because of the small number of patients and the lack of a matched control group, it shows for the first time that this combined therapy (GH + LHRHa) administered to short, pubertal boys after renal transplantation was not successful in increasing growth. Further studies are required to reach definitive conclusions.
Alonso
G
G
Departamento de Pediatría, Hospital Italiano de Buenos Aires, Argentina. pediatri@hitalba.edu.ar
Ferraris
J
J
Pasqualini
T
T
D001827:Body Height; D002648:Child; D003401:Creatine / Q000097:blood; D006130:Growth Disorders / Q000150:complications / Q000188:drug therapy*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D016030:Kidney Transplantation; D016729:Leuprolide / Q000627:therapeutic use*; D008297:Male
D019382:Human Growth Hormone; D016729:Leuprolide; D003401:Creatine