Glibenclamide induced chronic cholestasis simulating primary biliary cirrhosis: a case report.
A 43-year-old lady with long standing non-insulin dependent diabetes mellitus on glibenclamide presented with cholestatic liver disease. Initially she was thought to have developed primary biliary cirrhosis (PBC). When she made a spontaneous recovery following the withdrawal of glibenclamide, it became obvious that the patient had been suffering from drug-induced chronic cholestasis (DICC). The subtle differences between PBC and DICC are highlighted.
Ramanathan
M
M
Department of Medicine, Taiping Hospital, Perak.
Wahinuddin
S
S
Kew
S T
ST
D000328:Adult; D002779:Cholestasis / Q000139:chemically induced* / Q000175:diagnosis*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D005905:Glyburide / Q000009:adverse effects*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis*
D005905:Glyburide