Testosterone and muscle protein metabolism.
This presentation discusses recent investigations into testosterone's effects on muscle protein metabolism. Protein synthesis is the principal end point, but protein breakdown and the availability of an amino acid pool are important to the process of net muscle protein synthesis. The effects of other hormones--including growth hormone, oxoandrolone (a synthetically derived testosterone), and androstenedione--on muscle protein synthesis also are discussed. Effects in both normal and elderly men are considered.
Wolfe
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R
University of Texas Medical Branch, Galveston, USA.
Ferrando
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A
Sheffield-Moore
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M
Urban
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R
D000368:Aged; D000375:Aging / Q000187:drug effects / Q000502:physiology; D000596:Amino Acids / Q000187:drug effects / Q000502:physiology; D045930:Anabolic Agents / Q000378:metabolism / Q000627:therapeutic use; D000735:Androstenedione / Q000378:metabolism / Q000627:therapeutic use; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009124:Muscle Proteins / Q000187:drug effects / Q000378:metabolism*; D009133:Muscular Atrophy / Q000188:drug therapy / Q000209:etiology; D010074:Oxandrolone / Q000378:metabolism / Q000627:therapeutic use; D013739:Testosterone / Q000502:physiology*; D013997:Time Factors
D000596:Amino Acids; D045930:Anabolic Agents; D009124:Muscle Proteins; D013739:Testosterone; D000735:Androstenedione; D010074:Oxandrolone; D013006:Growth Hormone