Endocrine cells in the denervated intestine.
This study deals with the effects of myenteric denervation of the proximal jejunum on endocrine cell population of the crypt-villus unit, 5 months after treatment with benzalkonium chloride (BAC). Male Wistar albino rats weighing on average 100 g were allocated to two groups: the BAC group - the proximal jejunal serosa was treated with 2 mM BAC for 30 min, and the control group - treated with saline solution (0,9% NaCl). There was a significant reduction in neurone number in the jejunal myenteric plexus of the BAC group and the endocrine cell population (serotoninergic and argyrophilic cells) was significantly increased in this intestine segment. In conclusion, the present findings provide further evidence that the myenteric denervation induced by BAC may lead to the development of a local imbalance of the neurotransmitters, with a consequent induction of enteroendocrine cell (argyrophilic and serotoninergic cells) hyperplasia in the crypt and villus.
Santos
G C
GC
Department of Pathology, Faculty of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Zucoloto
S
S
Garcia
S B
SB
D000818:Animals; D001548:Benzalkonium Compounds; D002452:Cell Count / Q000187:drug effects; D019858:Enteroendocrine Cells / Q000473:pathology*; D006965:Hyperplasia / Q000139:chemically induced; D007583:Jejunum / Q000294:innervation*; D009474:Neurons / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D001548:Benzalkonium Compounds