The influence of glycoprotein hormones selected properties of selected properties of glycoprotein hormones on their absorption after intranasal administration in foxes.
The absorption of glycoprotein hormones, i.e. folitropin and lutropin, whose approximate molecular weight is 30,000 D, were estimated for the intranasal administration. The maximal hormone concentrations were observed 30 minutes after their administration. The maximal concentration of folitropin was 32% higher than the maximal concentration of lutropin. Bioavailability level for foliotropin was 138.58% compared to lutropin bioavailability level, which was considered the pattern bioavailability level (100%) in our experiments. It was established that the absorption of hormones from nasal mucous membrane depended not only on their molecular mass but also on the isoelectric point, content of carbohydrates and sialic acids. Hormonal substances of acid character, containing a greater content of carbohydrates and sialic acids (as in the case of folitropin) were absorbed from the nasal mucosa more rapidly.
Ryszka
F
F
Department of Applied Pharmacy and Drug Technology Silesian Medical Academy, Kasztanowa, Poland.
Dolinska
B
B
Suszka-Switek
A
A
D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D019540:Area Under Curve; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D005589:Foxes / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone