[Physiopathology of nephropathy studied with contrast media].
For the technological advances in diagnostic and therapeutic procedures, the use of intravenous contrast media in the hospital is more and more frequent. It can produce acute renal failure secondary to its nephrotoxicity known as contrast media nephropathy. This review describes the pathophysiologic mechanisms of contrast media injury, including cytotoxicity caused by hyperosmoloarity of contrast media, the hemodynamic factors and the role of the renin-angiotensin system, prostaglandins, oxygen free radicals, endothelin-1, adenosine, nitric oxide and others. The understanding of this information is of vital importance for the development of prophylactic strategies for contrast media nephropathy.
Morales Buenrostro
L E
LE
Departamento de Medicina Interna, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F.
Tellez Zenteno
J F
JF
Torre Delgadillo
A
A
D000241:Adenosine / Q000502:physiology; D003287:Contrast Media / Q000009:adverse effects*; D019332:Endothelin-1 / Q000502:physiology; D005609:Free Radicals; D006439:Hemodynamics; D006632:Histamine / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D017382:Reactive Oxygen Species / Q000502:physiology; D012307:Risk Factors
D003287:Contrast Media; D019332:Endothelin-1; D005609:Free Radicals; D011453:Prostaglandins; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D006632:Histamine; D000241:Adenosine