title: Molecular mechanisms of invasion by cancer cells, leukocytes and microorganisms.
abstract: Invasion is a phenotype common to cancer cells, leukocytes, parasites, bacteria and viruses, involving cell-cell adhesion, cell-matrix adhesion, proteolysis and motility. These activities are regulated by the cross talk between invaders and host. We discuss the invasion-related molecular interactions of E-cadherin, integrins, matrix metalloproteinases and the chemokine receptor RANTES.
authors.affiliation: Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Lauwaet
authors.forename: M J
authors.initials: MJ
authors.lastname: Oliveira
authors.forename: M
authors.initials: M
authors.lastname: Mareel
authors.forename: A
authors.initials: A
authors.lastname: Leroy
mesh_terms: D000818:Animals; D018407:Bacterial Physiological Phenomena; D015820:Cadherins / Q000378:metabolism; D002450:Cell Communication; D018946:Chemokine CCL5 / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D007962:Leukocytes / Q000502:physiology*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D010271:Parasites / Q000502:physiology*; D014407:Tumor Cells, Cultured; D018406:Virus Physiological Phenomena
chemical_list: D015820:Cadherins; D018946:Chemokine CCL5; D016023:Integrins; D020782:Matrix Metalloproteinases