title: Cerebellar cortical abiotrophy in two Portuguese Podenco littermates.
abstract: Cerebellar cortical abiotrophy in two Portuguese Podenco littermates is reported and discussed. The disease is characterized by progressive cerebellar ataxia with an early onset of two to three weeks. Extensive loss, degeneration, and necrosis of Purkinje cells particularly involved the cerebellar hemispheres. An autosomal recessive pattern of inheritance is suspected.
authors.affiliation: Department of Veterinary Pathology, University Utrecht, The Netherlands.
authors.forename: S E
authors.initials: SE
authors.lastname: van Tongern
authors.forename: I K
authors.initials: IK
authors.lastname: van Vonderen
authors.forename: J J
authors.initials: JJ
authors.lastname: van Nes
authors.forename: T S
authors.initials: TS
authors.lastname: van den Ingh
mesh_terms: D000818:Animals; D001947:Breeding; D002525:Cerebellar Cortex / Q000473:pathology*; D002526:Cerebellar Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D008297:Male; D011174:Portugal; D011689:Purkinje Cells / Q000473:pathology