title: Alumina-supported synthesis of antibacterial quinolines using microwaves.
abstract: 7-(5'-Alkyl-1',3',4'-thiadiazol/oxadiazol-2'-ylthio)-6 -fluoro-2,4-dimethylquinolines and 3-formyl-2-(2'-hydroxy- 1',4'-naphthoquinon-3'-yl)-4-methyl/6-methyl/7-quinolines have been synthesised by the reaction of 5-alkyl-1,3,4-thiadiazol/oxadiazol-2-thiols with 7-chloro-6-fluoro-2,4-dimethylquinoline and by the reaction of 2-hydroxy-1,4-naphthoquinone with 2-chloro-3-formyl-4-methyl/6-methyl/7-methyl/8-methylquinolines respectively on basic alumina using microwaves, the reaction time has been brought down from hours to seconds with improved yield as compared to conventional heating. The compounds were tested for their in vitro antibacterial activity. All compounds showed promising antibacterial activity. The best activity was observed by compounds 3a and 3f.
authors.affiliation: Department of Chemistry, University of Delhi, India. vpasmar.duchem@axcess.net.in
authors.forename: M
authors.initials: M
authors.lastname: Kidwai
authors.forename: K R
authors.initials: KR
authors.lastname: Bhushan
authors.forename: P
authors.initials: P
authors.lastname: Sapra
authors.forename: R K
authors.initials: RK
authors.lastname: Saxena
authors.forename: R
authors.initials: R
authors.lastname: Gupta
mesh_terms: D042462:4-Quinolones; D000537:Aluminum Oxide / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D007709:Klebsiella / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D013055:Spectrophotometry, Infrared
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D000537:Aluminum Oxide