title: Autonomic and neurohumoral control of postprandial blood pressure in healthy aging.
abstract: BACKGROUND
  Postprandial hypotension (PPH) is a common and morbid problem in elderly people that is associated with an impaired vascular response to meal digestion. Healthy aging in the absence of blood pressure elevation is associated with autonomic and neurohumoral changes that may influence the vascular response to meal ingestion. However, it is not known whether these age-related changes are associated with the development of PPH.
  
  
  METHODS
  We measured hemodynamic (blood pressure, heart rate, and forearm vascular resistance), autonomic (power spectral analysis of heart rate and blood pressure variability), and neurohumoral (plasma norepinephrine, renin, aldosterone, and endothelin) responses to a mixed 425 kilocalorie (kcal) meal in 89 rigorously screened healthy subjects aged 20-39, 40-59, and 60-83 years.
  
  
  RESULTS
  After the meal, supine mean arterial blood pressure fell significantly only in the middle-aged group by 5.4 +/- 7.9 mm Hg at 30 minutes (p = .02). Forearm vascular resistance fell after the meal in all age groups ( p = .0001). Older groups had higher plasma norepinephrine (p = .02), lower heart rate (p = .03), lower cardiovagal activity (p = .0001), and lower sympathetic vasomotor (p = .000) activity, but there was no difference in the response of these variables to a meal.
  
  
  CONCLUSIONS
  Healthy aging, in the absence of blood pressure elevation, alters the level of autonomic activity without further impairing the ability to maintain blood pressure during meal digestion. Hemodynamic, autonomic, and neurohumoral responses to meal ingestion remain unchanged in very healthy, normotensive elderly adults.
authors.affiliation: Hebrew Rehabilitation Center for Aged Research and Training Institute, Beth Israel/Deaconess Medical Center Department of Medicine and Harvard Medical School, Boston, Massachusetts 02131, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Oberman
authors.forename: M M
authors.initials: MM
authors.lastname: Gagnon
authors.forename: D K
authors.initials: DK
authors.lastname: Kiely
authors.forename: J C
authors.initials: JC
authors.lastname: Nelson
authors.forename: L A
authors.initials: LA
authors.lastname: Lipsitz
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001341:Autonomic Nervous System / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014660:Vasoactive Intestinal Peptide / Q000502:physiology*
chemical_list: D014660:Vasoactive Intestinal Peptide