title: Is Campylobacter lipopolysaccharide bearing a GD3 epitope essential for the pathogenesis of Guillain-Barré syndrome?
abstract: The hypothesis has been proposed that the GD3 ganglioside-like lipopolysaccharide (LPS) is essential for and functions in the development of Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) subsequent to Campylobacter jejuni enteritis. Our study showed that patients with GBS or MFS who had previously suffered diarrhea had anti-GD3 antibodies less often than those who had not had diarrhea. Sera from patients who showed GBS or MFS with the serologic evidence of prior C. jejuni infection had anti-GD3 antibodies less frequently than sera from those without evidence of infection. Statistical analysis showed that anti-GD3 antibodies were less frequent in patients with GBS or MFS from whom C. jejuni had been isolated than were other antiganglioside antibodies, such as anti-GM1 antibodies. These results could not support the above hypothesis.
authors.affiliation: Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan. yuki@dokkyomed.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Yuki
authors.forename: M
authors.initials: M
authors.lastname: Koga
authors.forename: K
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000208:Acute Disease; D000907:Antibodies, Bacterial / Q000097:blood*; D002169:Campylobacter Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016123:Campylobacter jejuni / Q000276:immunology* / Q000302:isolation & purification; D016022:Case-Control Studies; D003967:Diarrhea / Q000209:etiology / Q000276:immunology; D000939:Epitopes; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D005759:Gastroenteritis / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D020275:Guillain-Barre Syndrome / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007074:Immunoglobulin G; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D019846:Miller Fisher Syndrome / Q000276:immunology / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D000939:Epitopes; D005732:Gangliosides; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; C026226:ganglioside, GD3