title: [Decreased activity of 11-beta-hydroxysteroid dehydrogenase in patients with Cushing's syndrome].
abstract: BACKGROUND
  To study 11 beta-hydroxysteroid dehydrogenase activity in Cushing's syndrome.
  
  
  METHODS
  Measurements of free cortisol, cortisone, tetrahydrocortisol and tetrahydrocortisone in 24 h urine samples of patients with Cushing's syndrome and controls.
  
  
  RESULTS
  The cortisol to cortisone and tetrahydrocortisol to tetrahydrocortisone relationship was significant (in controls, r = 0.70; p < 0.0001, and r = 0.75; p < 0.0001) respectively, but it was not in patients with Cushing's syndrome.
  
  
  CONCLUSIONS
  11 beta-hydroxysteroid dehydrogenase activity is decreased in patients with Cushing's syndrome.
authors.affiliation: Servicio de Medicina Interna, Hospitales Universitarios Virgen del Rocío, Sevilla. stiefel@cica.es
authors.forename: P
authors.initials: P
authors.lastname: Stiefel
authors.forename: L
authors.initials: L
authors.lastname: Jiménez
authors.forename: J S
authors.initials: JS
authors.lastname: García-Morillo
authors.forename: A
authors.initials: A
authors.lastname: Leal
authors.forename: J
authors.initials: J
authors.lastname: Villar
authors.forename: J
authors.initials: J
authors.lastname: Carneado
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003348:Cortisone / Q000652:urine; D003480:Cushing Syndrome / Q000175:diagnosis / Q000201:enzymology* / Q000652:urine; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D015592:Immunoradiometric Assay; D008163:Luminescent Measurements; D008297:Male; D013760:Tetrahydrocortisol / Q000652:urine; D013761:Tetrahydrocortisone / Q000652:urine
chemical_list: D013761:Tetrahydrocortisone; D013760:Tetrahydrocortisol; D000324:Adrenocorticotropic Hormone; D006913:Hydroxysteroid Dehydrogenases; D003348:Cortisone; D006854:Hydrocortisone