Longitudinal study of serum copper and zinc levels and their distribution in blood proteins after acute myocardial infarction.
The levels and distribution of serum Cu and Zn were studied in patients diagnosed with acute myocardial infarction from the day of admission to the Cardiovascular Intensive Care Unit until the 10th day following the attack. The results obtained show that Cu increases significantly (p < 0.01) after the 5th day after the acute myocardial infarction, while Zn decreases significantly (p < 0.01) with respect to the control group from the first day on, with the lowest values being found on the 3rd day after the attack. Further, total serum Cu showed an excellent correlation with the albumin-bound and globulin-bound Cu (ceruloplasmin), as well as with the concentrations of both serum protein fractions. In contrast, total serum Zn only presents this correlation with Zn bound to albumin, but not with Zn bound to globulin nor with the albumin concentration. These findings suggest the existence of some type of relationship between the two fractions of the element bound to protein. This relationship is probably different for both metals.
Gomez
E
E
Department of Biochemical Chemistry, University Clinical Hospital, Faculty of Medicine, University of Zaragoza, Spain.
del Diego
C
C
Orden
I
I
Elósegui
L M
LM
Borque
L
L
Escanero
J F
JF
D000328:Adult; D000368:Aged; D000645:Ammonium Sulfate / Q000494:pharmacology; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000097:blood*; D005260:Female; D006801:Humans; D007700:Kinetics; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000378:metabolism; D015203:Reproducibility of Results; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D015032:Zinc / Q000097:blood*
D003300:Copper; D002570:Ceruloplasmin; D015032:Zinc; D000645:Ammonium Sulfate