title: Image analysis of mesothelioma. II. Discrimination of mesothelioma from metastatic serous ovarian adenocarcinoma.
abstract: OBJECTIVE
  To examine the utility of karyometric measurements in the differentiation of mesothelioma from metastatic serous ovarian adenocarcinoma.
  
  
  METHODS
  High-resolution images of 1,631 nuclei from 32 cases of mesothelioma and 742 nuclei from 15 cases of ovarian adenocarcinoma were recorded. A stepwise discriminant analysis and nonparametric classifier were applied.
  
  
  RESULTS
  Nuclei from these two diagnostic categories appear very similar and occupy feature space with significant overlap. A nonparametric classification procedure provided acceptable correct classification.
  
  
  CONCLUSIONS
  For certain regions in feature space, cases could be unequivocally classified.
authors.affiliation: Department of Pathology, Metaxa Cancer Institute, Piraeus, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Protopapa
authors.forename: G
authors.initials: G
authors.lastname: Delides
authors.forename: G
authors.initials: G
authors.lastname: Miaoulis
authors.forename: D
authors.initials: D
authors.lastname: Thompson
authors.forename: P H
authors.initials: PH
authors.lastname: Bartels
mesh_terms: D002467:Cell Nucleus / Q000648:ultrastructure; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis* / Q000235:genetics; D004273:DNA, Neoplasm / Q000648:ultrastructure; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007620:Karyometry; D008654:Mesothelioma / Q000175:diagnosis* / Q000235:genetics; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000235:genetics; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm