Preparation in high-shear mixer of sustained-release pellets by melt pelletisation.
The preparation of sustained-release pellets by melt pelletisation was investigated in a 10-l high shear mixer and ternary mixtures containing stearic acid as a melting binder, anhydrous lactose as a filler and theophylline as a model drug. A translated Doehlert matrix was applied for the optimisation of process variables and quality control of pellets characteristics. After determination of size distribution, the pellets were characterised with scanning electron microscopy, X-ray photoelectron spectroscopy and porosimetric analysis. Finally, the in vitro release from every single size fraction was evaluated and the release mechanism was analysed. Since the drug release rate decreased when enhancing the pellet size fraction, the 2000-microm fraction, exhibiting a substantially zero-order release, was selected for further in vivo biovailability studies. These data demonstrated that pellets based on the combination of stearic acid and lactose can be used to formulate sustained release pellets for theophylline.
Voinovich
D
D
Department of Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy. vojnovic@univ.trieste.it
Moneghini
M
M
Perissutti
B
B
Filipovic-Grcic
J
J
Grabnar
I
I
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
D003692:Delayed-Action Preparations; D013806:Theophylline