Grafting of stomach tissue into the duodenum in F344 rats results in chimeric crypts and tumor development.
Gastric tissue was transplanted from the fundic and pyloric mucosa of 8-week old female F344 rats into the duodenum of males. Autopsy, 12 months after the operation, revealed grafts associated with persistent stones in the duodenum and/or calcification in the tissue. Pepsinogen positive chimeric glands with goblet cells also appeared in the grafts which gave rise to tumors in 18 out of 45 animals (40%). In conclusion, stomach grafts re-differentiate into intestine with goblet cells in the duodenum and this process predisposes to tumor development.
Watanabe
H
H
Dept. of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan. tonko@ipc.hiroshima-u.ac.jp
Ando
Y
Y
Uesaka
T
T
Ishimura
Y
Y
Shiraki
K
K
Lu
H
H
Ohara
M
M
Shoji
S
S
Katoh
O
O
D000818:Animals; D002114:Calcinosis / Q000209:etiology / Q000473:pathology; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D002678:Chimera; D004378:Duodenal Diseases / Q000209:etiology / Q000473:pathology; D004386:Duodenum / Q000473:pathology / Q000601:surgery*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000209:etiology* / Q000473:pathology; D020397:Goblet Cells / Q000473:pathology; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013270:Stomach / Q000637:transplantation*