Synthesis and degradation characteristics of salicylic acid-derived poly(anhydride-esters).
A biodegradable poly(anhydride-ester) was synthesized by melt condensation polymerization of the acetylated monomer to yield a novel polymeric prodrug. The polymer we have synthesized is composed of alkyl chains linked by ester bonds to aromatic moieties, specifically salicylic acid--the active component of aspirin. With the medicinal properties attributed to salicylic acid and the ease of metabolism, the incorporation of this compound into a polymer backbone yields a polymeric prodrug that may have potential in a variety of applications (i.e., inflammatory bowel disease). For these reasons, we have designed a synthetic scheme that yields the desired poly(anhydride-ester). The in vitro hydrolytic degradation of these polymers has been performed and results indicate that the polymer degradation rate is pH-dependent.
Erdmann
L
L
Department of Chemistry, Rutgers University, Piscataway, NJ 08854-8087, USA.
Uhrich
K E
KE
D000812:Anhydrides / Q000138:chemical synthesis* / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry; D006868:Hydrolysis; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D020156:Salicylic Acid
D000812:Anhydrides; D001672:Biocompatible Materials; D004952:Esters; D011108:Polymers; D020156:Salicylic Acid