title: Fractionated radiotherapy of lentigo maligna and lentigo maligna melanoma in 64 patients.
abstract: Between 1987 and 1998, 64 patients with lentigo maligna (LM) (n = 42) or lentigo maligna melanoma (LMM) (n = 22) were treated by fractionated radiotherapy. In all 22 patients with LMM, excision of the nodular part of the LMM was performed before radiation of the residual lentiginous tumor. During the follow-up period of 1 to 96 months (mean, 23 months; median, 15 months), none of the 42 patients with LM displayed any signs of recurrence of LM after radiation therapy alone. Of the 22 patients with LMM, only 2 patients showed local recurrence of the tumor, salvaged by excision in both cases. One patient with LMM suffered from metastatic disease without local recurrence of the melanoma 44 months after radiation therapy. The cosmetic results of radiotherapy were good or excellent in the vast majority of patients, with only a few experiencing hypopigmentation or hyperpigmentation in the irradiated area. Fractionated radiation therapy with superficial x-rays is an effective method of treatment of LM associated with low morbidity and leading to clinical results comparable to those of surgical excision.
authors.affiliation: Departments of Dermatology, Ludwig-Maximilians University, Munich, Germany.
authors.forename: M H
authors.initials: MH
authors.lastname: Schmid-Wendtner
authors.forename: B
authors.initials: B
authors.lastname: Brunner
authors.forename: B
authors.initials: B
authors.lastname: Konz
authors.forename: P
authors.initials: P
authors.lastname: Kaudewitz
authors.forename: C M
authors.initials: CM
authors.lastname: Wendtner
authors.forename: R U
authors.initials: RU
authors.lastname: Peter
authors.forename: G
authors.initials: G
authors.lastname: Plewig
authors.forename: M
authors.initials: M
authors.lastname: Volkenandt
mesh_terms: D000368:Aged; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome