Serum feline trypsin-like immunoreactivity following administration of ceruletide to healthy cats.
OBJECTIVE
To determine changes in serum feline trypsin-like immunoreactivity (fTLI) in response to administration of ceruletide to healthy cats.


METHODS
11 healthy cats.


METHODS
Serum fTLI was determined, using a radioimmunoassay, before and 10, 20, 30, 40, and 50 minutes after IM administration of ceruletide (0.3 mg/kg [0.14 mg/lb]).


RESULTS
Mean +/- SD baseline serum fTLI was 23.1 +/- 4.1 mg/L. There was a statistically significant, but clinically unimportant, increase in serum fTLI 10 and 30 minutes after ceruletide administration.


CONCLUSIONS
In healthy cats, administration of ceruletide induced a statistically significant, but clinically unimportant, increase in serum fTLI. Whether responses in cats with exocrine pancreatic disorders would be different is unknown, but results suggest that a ceruletide stimulation test would likely not be useful for differentiating between healthy cats and cats with subclinical chronic exocrine pancreatic disorders.
Spillmann
T
T
Medizinische und Gerichtliche Veterinärklinik I der Justus-Liebig-Universität Giessen, Innere Krankheiten der Kleintiere, Germany.
Jacob
I
I
Steiner
J M
JM
Williams
D A
DA
Failing
K
K
D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis*; D002415:Cats; D002108:Ceruletide / Q000494:pharmacology*; D010182:Pancreatic Diseases / Q000175:diagnosis / Q000662:veterinary*; D011863:Radioimmunoassay / Q000662:veterinary; D014357:Trypsin / Q000097:blood*
D002108:Ceruletide; D014357:Trypsin