title: Acute neurologic decompensation in an infant with cobalamin deficiency exposed to nitrous oxide.
abstract: After exposure to nitrous oxide, an infant with unrecognized cobalamin deficiency developed neurologic deterioration and pancytopenia. Hematologic recovery and partial resolution of his neurologic changes followed repletion of the vitamin. Nitrous oxide depletes bioavailable cobalamin and may be a dangerous anesthetic in patients with cobalamin deficiency.
authors.affiliation: Departments of Pediatrics, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: K
authors.initials: K
authors.lastname: Felmet
authors.forename: B
authors.initials: B
authors.lastname: Robins
authors.forename: D
authors.initials: D
authors.lastname: Tilford
authors.forename: S J
authors.initials: SJ
authors.lastname: Hayflick
mesh_terms: D000749:Anemia, Megaloblastic / Q000209:etiology; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D001264:Athetosis / Q000209:etiology*; D002658:Developmental Disabilities / Q000209:etiology*; D005221:Fatigue / Q000209:etiology; D005334:Fever / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D009609:Nitrous Oxide / Q000009:adverse effects*; D010198:Pancytopenia / Q000209:etiology; D014806:Vitamin B 12 Deficiency / Q000150:complications*
chemical_list: D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide