Current status of DNA vaccines in veterinary medicine.
DNA vaccination entails administration of the DNA itself encoding antigen to direct synthesis of the antigen directly in the target organism. The target organism's immune system recognizes the antigen, and generates humoral (antibody)- and/or cell-mediated immune response. DNA vaccines afford numerous advantages over conventional vaccines, including ease of production, stability and transport. They overcome the need to cultivate dangerous infectious agents, and provide a possibility to vaccinate against multiple pathogens in a single shot. DNA vaccination is beginning to be explored for many pathogens of veterinary interest. The status of DNA vaccines in poultry, livestock and companion animals is reviewed here. While examples of DNA vaccines being tested in the veterinary field are not numerous, the early studies highlight the potential DNA vaccinology offers in veterinary medicine.
Krishnan
B R
BR
Animal Health Biological Discovery, Central Research Division, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. krishnanr@groton.pfizer.com
D000818:Animals; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D014730:Veterinary Medicine; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*
D019444:Vaccines, DNA