Water stimulation of the posterior oral cavity induces inhibition of gastric motility.
The response of gastric motility to the administration of water and saline in the larynx and epiglottis was investigated in urethan-chloralose anesthetized rats. Administration of water inhibited motility of the distal stomach, but 0.15 M NaCl did not induce the inhibitory response. Bilateral sectioning of the superior laryngeal nerve (SLN) abolished the inhibitory response induced by water. Bilateral cervical vagotomies abolished the inhibitory responses, although spinal transection did not affect the inhibitory response. These inhibitory responses have been observed in immobilized animals. The degree of inhibition by water and hypotonic saline was negatively correlated with the sodium concentration. In contrast, the degree of inhibition to hypertonic saline was positively correlated with the sodium concentration. The proximal stomach also showed a reduction in intragastric pressure in response to the administration of water. These findings suggest that water-responsive afferent neurons in the SLN suppress gastric motility via the vagal efferent nerve.
Kobashi
M
M
Department of Oral Physiology, Okayama University Dental School, Okayama 700-8525, Japan. mkobashi@den.okayama-u.ac.jp
Mizutani
M
M
Matsuo
R
R
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000502:physiology*; D004558:Electric Stimulation; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology*; D007823:Laryngeal Nerves / Q000166:cytology / Q000502:physiology / Q000601:surgery; D007830:Larynx / Q000502:physiology; D008297:Male; D009055:Mouth / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D012965:Sodium Chloride / Q000494:pharmacology; D013119:Spinal Cord Injuries; D013270:Stomach / Q000294:innervation* / Q000502:physiology; D014628:Vagotomy; D014630:Vagus Nerve / Q000166:cytology / Q000502:physiology / Q000601:surgery; D014867:Water / Q000494:pharmacology
D014867:Water; D012965:Sodium Chloride