Roundtable conference on tissue oxygenation in acute medicine, Brussels, Belgium, 14-16 March 1998.
* Nutritional tissue perfusion and tissue metabolic demand are heterogeneously distributed. * Oxygen diffusion occurs preferentially at the precapillary arteriolar level. * Determination of adequacy of tissue oxygenation requires local organ measurements. * While there remains considerable variability in individual RBC transfusion practices, a recent clinical trial questioned the efficacy of RBC transfusion to hemoglobin concentrations greater than 80 gm/l in patients without heart disease [63]. * RBC substitutes, including cell-free hemoglobin solutions and PFC solutions are efficacious, yet may exhibit a number of direct vascular effects.
Sibbald
W J
WJ
Program in Critical Care Medicine, Faculty of Medicine and Dentistry, University of Western Ontario, London, Canada. wsibbald@julian.uwo.ca
Messmer
K
K
Fink
M P
MP
D001530:Belgium; D001692:Biological Transport; D001775:Blood Circulation / Q000502:physiology*; D001802:Blood Substitutes / Q000737:chemistry / Q000627:therapeutic use; D005466:Fluorocarbons / Q000737:chemistry / Q000627:therapeutic use; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D008833:Microcirculation / Q000502:physiology; D008955:Models, Cardiovascular; D010100:Oxygen / Q000032:analysis / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D015424:Reperfusion / Q000379:methods*; D014018:Tissue Distribution
D001802:Blood Substitutes; D005466:Fluorocarbons; D010100:Oxygen