title: Is systolic pressure a better target for antihypertensive treatment than diastolic pressure?
abstract: BACKGROUND
  Diastolic blood pressure has been evaluated in different prospective cohort studies and in pharmacological intervention trials, which have shown the increased risk of cardiovascular events in hypertensive patients and the benefits of antihypertensive therapy.
  
  
  OBJECTIVE
  To show that systolic blood pressure is at least as important as, or even more important than, diastolic blood pressure as a risk factor for cardiovascular complications.
  
  
  METHODS
  Review of medical literature.
  
  
  RESULTS
  Large epidemiological trials such as the Multiple Risk Factors Intervention Trial (MRFIT) and the Framingham study have shown that systolic blood pressure is an independent, continuous and modifiable risk for all cardiovascular complications, and in elderly subjects isolated systolic hypertension is the most frequent form of hypertension. In elderly subjects the increased stiffness of large arteries is responsible for the early reflection of pulse wave and for the decrease in diastolic blood pressure due to reduced recoil of large arteries. This is summarized in the increase in pulse pressure, which is directly related to the risk of cardiovascular complications. Three large intervention trials in elderly patients with isolated systolic hypertension have shown the relevant cardiovascular benefit of pharmacological reduction of elevated systolic blood pressure and normal diastolic values: the cardiovascular benefit is similar to that found in the general hypertensive population and in elderly patients with systolic-diastolic hypertension.
  
  
  CONCLUSIONS
  Systolic blood pressure represents an important risk factor for cardiovascular events which can be prevented or reduced with pharmacological treatment.
authors.affiliation: Istituto Auxologico Italiano and San Luca Hospital, IRCCS, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Leonetti
authors.forename: C
authors.initials: C
authors.lastname: Cuspidi
authors.forename: M
authors.initials: M
authors.lastname: Facchini
authors.forename: M
authors.initials: M
authors.lastname: Stramba-Badiale
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D003971:Diastole / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D013599:Systole / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents