Non invasive ventilation in the treatment of FUdr-induced lesional pulmonary oedema.
2-deoxy-5-fluorouridine, also known as floxuridine (FUdr) is a fluoropyridine antimetabolite, used in the treatment of metastatic renal cell carcinoma. We report the first case of lesional pulmonary oedema developed after receiving Fudr, recently treated in our unit. The patient refused endotracheal intubation, and was successfully treated associating noninvasive ventilation (NIV) with full-face mask to steroid treatment. The authors conclude that mechanical ventilation via face-mask can be an effective, comfortable, dignified method of support for patients with end-stage disease and acute respiratory failure.
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Università degli Studi Roma La Sapienza.
Spadetta
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Antonelli
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Ruscio
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Gionfrida
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D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D005467:Floxuridine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D008297:Male; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000628:therapy*; D012121:Respiration, Artificial
D000964:Antimetabolites, Antineoplastic; D005467:Floxuridine