title: Diagnosis and management of juvenile hyperthyroidism in Germany: a retrospective multicenter study.
abstract: This retrospective multicenter study was designed to survey the management of childhood and adolescent hyperthyroidism in six pediatric endocrinological units in Germany. Fifty-six patients aged between 1.1 and 17.0 yr (median 10.5 yr) were enrolled. Data were collected retrospectively from the patients' records by a trained pediatric endocrinologist using standardized questionnaires. After the diagnosis of hyperthyroidism was established on the basis of clinical and biological findings, treatment with antithyroid drugs (carbimazole, methimazole, thiamazole, propylthiouracil) was started in all patients. In 55/56 of the patients treated with antithyroid drugs, euthyroidism was achieved (98%). However, 26 patients (47%) were still hyperthyroid after discontinuation of the medication. Eight children with continued hyperthyroidism ultimately underwent subtotal thyroidectomy 13-136 (median 28) months after the initial diagnosis. Management principles of the participating centers were heterogeneous. As a consequence, prospective multicenter studies are urgently needed to establish clear standards for the diagnosis and therapy of childhood hyperthyroidism.
authors.affiliation: Department of Pediatrics, University of Erlangen-Nürnberg, Germany. JoergWDoetsch@yahoo.com
authors.forename: J
authors.initials: J
authors.lastname: Dötsch
authors.forename: T
authors.initials: T
authors.lastname: Siebler
authors.forename: B P
authors.initials: BP
authors.lastname: Hauffa
authors.forename: B
authors.initials: B
authors.lastname: Doeker
authors.forename: W
authors.initials: W
authors.lastname: Andler
authors.forename: M
authors.initials: M
authors.lastname: Bettendorf
authors.forename: U
authors.initials: U
authors.lastname: Heinrich
authors.forename: B
authors.initials: B
authors.lastname: Gohlke
authors.forename: N
authors.initials: N
authors.lastname: Albers
authors.forename: H
authors.initials: H
authors.lastname: Willgerodt
authors.forename: W
authors.initials: W
authors.lastname: Kiess
mesh_terms: D000293:Adolescent; D013956:Antithyroid Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis* / Q000188:drug therapy*; D007223:Infant; D008297:Male; D012189:Retrospective Studies
chemical_list: D013956:Antithyroid Agents