title: Pyronaridine: an effective antimalarial against multidrug-resistant malaria.
abstract: Pyronaridine, administered intramuscularly (im) to Swiss mice infected with the lethal multidrug-resistant Plasmodium yoelii nigeriensis, was found to exert high blood schizontocidal activity. The efficacy of doses of pyronaridine ranging from 0.625 to 30 mg (base/kg) was evaluated using a 4 day treatment schedule (drug was administered at 0, 24, 48 and 72 hrs). It was found that doses of 2.5mg/ kg and higher protected animals completely from the lethal effects of the parasite. The same degree of protection was found when the treatment duration was reduced to 3 days. This study shows that pyronaridine is a potentially useful antimalarial drug that could be exploited for the control of multidrug-resistant malaria infection.
authors.affiliation: Division of Microbiology and Parasitology, Central Drug Research Institute, Lucknow, India.
authors.forename: G P
authors.initials: GP
authors.lastname: Dutta
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: A
authors.initials: A
authors.lastname: Awasthi
authors.forename: M
authors.initials: M
authors.lastname: Mishra
authors.forename: R
authors.initials: R
authors.lastname: Tripathi
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D018432:Drug Resistance, Multiple; D008288:Malaria / Q000097:blood / Q000188:drug therapy*; D051379:Mice; D009287:Naphthyridines / Q000097:blood / Q000494:pharmacology*; D010967:Plasmodium yoelii
chemical_list: D000962:Antimalarials; D009287:Naphthyridines; C027871:pyronaridine