The sophisticated survival strategies of the pathogen Listeria monocytogenes.
The function of the ActA protein of Listeria monocytogenes has been partially elucidated. These results illustrate the sophistication with which intracellular pathogens like Listeria use the host cell to their advantage, and have provided new insights into some of the molecular mechanisms of complex cell functions such as actin-promoted cell motility. The clarification of these processes is of fundamental importance not only for understanding elementary processes such as development and growth, but also for the treatment of both diseases caused by cytopathogenic bacteria such as Listeria and pathophysiological processes arising from disorders in cell motility and cell adhesion.
Wehland
J
J
Gesellschaft für Biotechnologische Forschung (GBF), Braunschweig, Germany. jwe@gbf.de
Carl
U D
UD
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology; D001431:Bacteriological Techniques; D001665:Binding Sites; D002352:Carrier Proteins / Q000502:physiology; D003285:Contractile Proteins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D008089:Listeria monocytogenes / Q000472:pathogenicity*; D008565:Membrane Proteins / Q000502:physiology; D008840:Microfilament Proteins / Q000502:physiology; D008856:Microscopy, Fluorescence; D008969:Molecular Sequence Data; D051304:Profilins
D001426:Bacterial Proteins; D002352:Carrier Proteins; D003285:Contractile Proteins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; C092744:ENA-VASP proteins; C102176:Enah protein, mouse; D008565:Membrane Proteins; D008840:Microfilament Proteins; D051304:Profilins; C072980:actA protein, Listeria monocytogenes