title: Screening of five drugs for efficacy against Babesia felis in experimentally infected cats.
abstract: The efficacy of 5 drugs was tested against experimental Babesia felis infection in domestic cats. Two of the drugs, rifampicin and a sulphadiazine-trimethoprim combination, appeared to have an anti-parasitic effect, but were inferior to primaquine. The other 3 drugs, buparvaquone, enrofloxacin and danofloxacin, had no significant anti-babesial effect.
authors.affiliation: Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa. bpenzhorn@op.up.ac.za
authors.forename: B L
authors.initials: BL
authors.lastname: Penzhorn
authors.forename: B D
authors.initials: BD
authors.lastname: Lewis
authors.forename: L M
authors.initials: LM
authors.lastname: López-Rebollar
authors.forename: G E
authors.initials: GE
authors.lastname: Swan
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001404:Babesiosis / Q000188:drug therapy*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004338:Drug Combinations; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D006400:Hematocrit / Q000662:veterinary; D009285:Naphthoquinones / Q000627:therapeutic use; D018512:Parasitemia / Q000188:drug therapy*; D011319:Primaquine / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D004338:Drug Combinations; D024841:Fluoroquinolones; D009285:Naphthoquinones; D015363:Quinolones; C046326:buparvaquone; D013411:Sulfadiazine; C068581:danofloxacin; D000077422:Enrofloxacin; D014295:Trimethoprim; D011319:Primaquine; D012293:Rifampin