title: Cl(-) secretion in colonic epithelial cells induced by the vibrio parahaemolyticus hemolytic toxin related to thermostable direct hemolysin.
abstract: A hemolytic toxin related to thermostable direct hemolysin (TDH), TDH-related hemolysin (TRH), produced by Kanagawa-phenomenon-negative Vibrio parahaemolyticus is suspected of playing an important, but yet-to-be-elucidated role in diarrhea caused by this organism. In cultured human colonic epithelial cells, TRH increases Cl(-) secretion, followed by elevation of intracellular calcium.
authors.affiliation: Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565-0871, 770-8503, Japan. akiratak@biken.osaka-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Kenjyo
authors.forename: K
authors.initials: K
authors.lastname: Imura
authors.forename: Y
authors.initials: Y
authors.lastname: Myonsun
authors.forename: T
authors.initials: T
authors.lastname: Honda
mesh_terms: D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology; D018938:Caco-2 Cells; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000187:drug effects; D006460:Hemolysin Proteins / Q000633:toxicity*; D006801:Humans; D014736:Vibrio parahaemolyticus / Q000472:pathogenicity*
chemical_list: C505032:CFTR protein, human; D002712:Chlorides; D006460:Hemolysin Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D002118:Calcium