Testosterone replacement and the physiologic aspects of aging in men.
Clinical and epidemiologic studies, along with basic scientific research, have shown a trend toward androgen deficiency in aging males. The focus of the clinical investigations described here is to determine whether testosterone deficiency is a physiologic cause of the aging process and whether testosterone replacement might prevent or ameliorate a decline in quality of life associated with age-related decline in physical and psychological functioning.
Morley
J E
JE
Geriatric Research, Education and Clinical Center, St Louis VA Medical Center, Mo., USA.
D000203:Activities of Daily Living; D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000502:physiology* / Q000523:psychology; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D019317:Evidence-Based Medicine; D020249:Hormone Replacement Therapy / Q000009:adverse effects / Q000379:methods* / Q000523:psychology; D006801:Humans; D008297:Male; D008403:Mass Screening; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009133:Muscular Atrophy / Q000188:drug therapy / Q000209:etiology; D011788:Quality of Life; D012107:Research Design; D012449:Safety; D012725:Sexual Behavior / Q000187:drug effects / Q000502:physiology / Q000523:psychology; D013739:Testosterone / Q000172:deficiency* / Q000627:therapeutic use*
D013739:Testosterone