title: [Dynamic magnetic resonance tomography (MRI): a follow-up study after femur core decompression and instillation of recombinant human bone morphogenetic protein-2 (rhBMP-2) in avascular femur head necrosis].
abstract: OBJECTIVE
  The aim of the study was to test the use of dynamic magnetic resonance imaging study with Gd-DTPA-application and the dynamic changes of signal intensity at patients with avascular femoral head necrosis after having installed rhBMP-2 and/or decompressed the core.
  
  
  METHODS
  Six patients with avascular necrosis of the femoral head ARCO-stage I- or II-lesions were treated surgically by femoral head core decompression. Three of these patients were additionally treated with rhBMP-2-instillation. The progression or regression could be confirmed by T1- and T2-weighted spinecho-sequences (zero, four, ten, sixteen weeks and 24 months follow up).
  
  
  RESULTS
  Corresponding ARCO-classification with partly more sensitive measurement of vitality signs in comparison to the optical x-ray classification. The objective, quantitative measurement of signal intensity post contrast medium reduces the influence of experience and level of education. The dynamic sequences results are reproducible.
  
  
  CONCLUSIONS
  The dynamic magnetic resonance imaging study after Gd-DTPA-application and the dynamic changes of signal intensity after Gd-DTPA enhancement in the necrotic areas of the femoral head were the important subject of our study and it seems, that these sequencies and the ascertainment of signal intensity changes will be an efficient method for judgement of vitality, vascularisation and perfusion after therapeutical intervention. Combination of femoral head core decompression and rhBMP-2-instillation for the purpose of osseous regeneration seems to stabilize the affection.
authors.affiliation: Strahlenklinik und Poliklinik, Humboldt-Universität zu Berlin.
authors.forename: H
authors.initials: H
authors.lastname: Schedel
authors.forename: A
authors.initials: A
authors.lastname: Schneller
authors.forename: T
authors.initials: T
authors.lastname: Vogl
authors.forename: H F
authors.initials: HF
authors.lastname: Müller
authors.forename: J
authors.initials: J
authors.lastname: Mäurer
authors.forename: N
authors.initials: N
authors.lastname: Südkamp
authors.forename: A
authors.initials: A
authors.lastname: Eisenschenk
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000328:Adult; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage*; D001861:Bone Regeneration; D003287:Contrast Media / Q000008:administration & dosage; D019299:Decompression, Surgical / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods; D005260:Female; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000601:surgery*; D005500:Follow-Up Studies; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011994:Recombinant Proteins / Q000008:administration & dosage; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
chemical_list: D019485:Bone Morphogenetic Proteins; D003287:Contrast Media; D011994:Recombinant Proteins; D019786:Gadolinium DTPA