title: Lymphohistiocytic and granulomatous phlebitis in penile lichen sclerosus.
abstract: Lichen sclerosus (LS) is a chronic inflammatory disease of unknown etiology that may affect the genital and/or extragenital skin of individuals of either sex at all ages. In boys, the prepuce is the most common site of involvement. The diagnostic criteria of LS include the presence of inflammatory infiltrates mainly composed of T lymphocytes. We report on two cases of LS of the prepuce because of the unusual feature of lymphocytic (CD45RO+ and CD20+), histiocytic (CD68+), and granulomatous phlebitis. This lesion was not present in a group of another 18 cases of childhood penile LS. We have not been able to find any references describing and illustrating inflammatory involvement of the dermal vein walls in LS. Unlike the data reported in the literature, the dermal inflammatory infiltrates of these two cases showed a similar proportion of B and T lymphocytes in addition to frequent CD68+ histiocytes.
authors.affiliation: Servicio de Pathología, Hospital de Niños Superiora Sor María Ludovica, La Plata, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Cabaleiro
authors.forename: R M
authors.initials: RM
authors.lastname: Drut
authors.forename: R
authors.initials: R
authors.lastname: Drut
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000378:metabolism; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D006099:Granuloma / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D018459:Lichen Sclerosus et Atrophicus / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D027383:Papillomaviridae / Q000235:genetics; D010409:Penile Diseases / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D010689:Phlebitis / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D016133:Polymerase Chain Reaction
chemical_list: D015703:Antigens, CD; D004279:DNA, Viral