Interaction of carbamazepine and phenobarbital in rabbits.
The interaction of carbamazepine and phenobarbital in rabbits was investigated. The drugs were administered to the rabbit orally as a single dose. By simultaneous administration the sequence of drugs was varied, with an interval between doses of 15 min. The doses of carbamazepine and phenobarbital were 100 and 25 mg, respectively. It was established that phenobarbital appears to be an inductor for carbamazepine independently sequence of administration of the drugs. Carbamazepine reveals inductive properties for phenobarbital in the case where phenobarbital enteres in the organism first. It was ascertained also that, by simultaneous administration, these drugs reduce absorption of each other in plasma.
Rukhadze
M D
MD
Department of Chemistry, Tbilisi State University, Chavchavadze Avenue 3, Tbilisi 380028, Republic of Georgia.
Alexishvili
M M
MM
Okujava
N V
NV
Sebiskveradze
M V
MV
Okujava
V M
VM
Tsagareli
S K
SK
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D010634:Phenobarbital / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D011817:Rabbits
D000927:Anticonvulsants; D002220:Carbamazepine; D010634:Phenobarbital