title: meso-tetraphenylporphyrin dimer derivatives as potential photosensitizers in photodynamic therapy. Part 2.
abstract: Studies on the synthesis, singlet oxygen and fluorescence yields and pharmacokinetic properties of three different dimeric porphyrins with an amide linkage (D2-D4) are described and compared with the results recently reported for a dimeric porphyrin (D1). The pharmacokinetic behavior of all dimers were examined in Balb/c mice bearing MS-2 fibrosarcomas. The maximal efficiency and selectivity of photosensitizer accumulation in each tumor tissue takes place at 24 h after drug administration of 1.0 mg kg-1 into DL-alpha-dipalmitoylphosphatidylcholine liposomes by intravenous injection. Since the dimeric porphyrins exhibit high quantum yields of singlet oxygen generation, long triplet lifetimes and high photostability, the results obtained suggest that the evaluated dimeric structures may be promising candidates for further use in PDT experiments. The results also allow the possibility to establish a correlation between the chemical structure of the dyes and the efficiency/selectivity of the tumor accumulation and can be used for building up optimal photosensitizing agents for tumors.
authors.affiliation: Department of Chemistry, University of Aveiro, Portugal.
authors.forename: M A
authors.initials: MA
authors.lastname: Faustino
authors.forename: M G
authors.initials: MG
authors.lastname: Neves
authors.forename: J A
authors.initials: JA
authors.lastname: Cavaleiro
authors.forename: M
authors.initials: M
authors.lastname: Neumann
authors.forename: H D
authors.initials: HD
authors.lastname: Brauer
authors.forename: G
authors.initials: G
authors.lastname: Jori
mesh_terms: D000818:Animals; D019281:Dimerization; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins