Progressive nodular histiocytosis accompanied by systemic disorders.
Progressive nodular histiocytosis is a proliferative process of histiocytes, the main element of which is the dermal dendrocyte. It is considered to form part of a group of histiocytic disorders related to juvenile xanthogranuloma, which also includes xanthoma disseminatum, benign cephalic histiocytosis, spindle cell xanthogranuloma and generalized eruptive histiocytosis; disorders which perhaps represent the spectrum of one single entity. We present the case of a 57-year-old man who, for 26 years, had had a progressively deforming process of cutaneous lesions, with systemic involvement, including chronic myeloid leukaemia, hepatosplenomegaly, hypothyroidism, hyperuricaemia and hypocholesterolaemia. We have not been able to establish precisely the relationship between these features.
Gonzalez Ruíz
A
A
Dermatology and Pathology Services, University Hospital, Valladolid, Spain.
Bernal Ruíz
A I
AI
Aragoneses Fraile
H
H
Peral Martinez
I
I
García Muñoz
M
M
D002784:Cholesterol / Q000097:blood; D006529:Hepatomegaly / Q000209:etiology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications; D008297:Male; D008875:Middle Aged; D013163:Splenomegaly / Q000209:etiology; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D002784:Cholesterol