[Epidermal growth factor receptors in malignant and benign tumors in children].
The radioligand technique was used to study the amount of epidermal growth factor receptors (EGFR) in malignant and benign tumors in 32 children aged 8 months to 17 years. The membranous fraction of 11 of the 32 tumors studied showed EGFR equal to 10.1 to 1327 fmol/mg (163.0 +/- 117.5 fmol/mg, median 38.0 fmol/mg). The greatest amount of EGFR was found in breast fibroadenomas. There was no clear relationship of the frequency and level of EGFR expression to a nosological tumor entity in children. A possible role of the EGFR system in tumors in children is discussed.
Kushlinskiĭ
N E
NE
Gershteĭn
E S
ES
Solov'ev
Iu N
IuN
Dumbraĭs
K O
KO
Kostyleva
O I
OI
Durnov
L A
LA
D000293:Adolescent; D014408:Biomarkers, Tumor / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D066246:ErbB Receptors / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis
D014408:Biomarkers, Tumor; D066246:ErbB Receptors