The effect of Plantago ovata on humoral immune responses in experimental animals.
The effect of the aqueous extract of Plantago ovata (PO) (Plantaginaceae) consisting of a mixture of polysaccharides and glycoside on humoral immune responses was studied. In rabbits, after oral administration of PO (0.5 g/kg) a significant decrease in anti-HD antibody titre was observed in primary response. Intraperitoneal injection of 0.25 g/kg of PO in mice prior to immunisation with sheep red blood cells (SRBC) resulted in a significant decrease in hemagglutinating antibody (HD) titre. Oral administration and intraperitoneal injection of 0.25 and 0.5 g/kg of PO resulted in a significant increase in white blood cells (WBC) and spleen leukocytes counts. The spleen weight also increased with intraperitoneal injection (0.25 and 0.5 g/kg) and oral administration of 0.5 g/kg of PO. Present results indicate that PO can suppress the humoral immune responses, especially in primary immune response.
Rezaeipoor
R
R
Immunology Department, Shaheed Beheshti University of Medical Sciences, PO Box 19835-145, Tehran, Iran. okhravi@khayam.ut.ac.ir
Saeidnia
S
S
Kamalinejad
M
M
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006386:Hemagglutination Tests; D007492:Iran; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010943:Plantago / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology; D011817:Rabbits; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D006027:Glycosides; D010936:Plant Extracts; D011134:Polysaccharides