Transformation of triclosan by Trametes versicolor and Pycnoporus cinnabarinus.
We investigated the ability of Trametes versicolor and Pycnoporous cinnabarinus to metabolize triclosan. T. versicolor produced three metabolites, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-xylopyranoside, 2-O-(2,4,4'-trichlorodiphenyl ether)-beta-D-glucopyranoside, and 2,4-dichlorophenol. P. cinnabarinus converted triclosan to 2,4, 4'-trichloro-2'-methoxydiphenyl ether and the glucoside conjugate known from T. versicolor. The conjugates showed a distinctly lower cytotoxic and microbicidal activity than triclosan did.
Hundt
K
K
Institute of Microbiology and Molecular Biology, Ernst-Moritz-Arndt-University, D-17487 Greifswald, Germany. kai.hundt@plasmaselect.com
Martin
D
D
Hammer
E
E
Jonas
U
U
Kindermann
M K
MK
Schauer
F
F
D000891:Anti-Infective Agents, Local / Q000378:metabolism; D001487:Basidiomycota / Q000254:growth & development / Q000378:metabolism*; D001673:Biodegradation, Environmental; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D014260:Triclosan / Q000378:metabolism*
D000891:Anti-Infective Agents, Local; D014260:Triclosan