Relative hypoleptinemia in patients with type 1 and type 2 diabetes mellitus.
OBJECTIVE
To determine the relation between plasma leptin concentrations and metabolic control in human diabetes mellitus.


METHODS
Cross sectional study consisting of 156 patients with diabetes mellitus type 1 (n=42), type 2 (n=114), and non-diabetic subjects (n=74).


RESULTS
Plasma leptin concentrations were lower (P<0.05) in type 1 (8.3+/-1.7 ng/ml) and type 2 diabetic (14.9+/-1.8 ng/ml) than in non-diabetic humans (18.3+/-1.9 ng/ml). Only female type 1 and type 2 diabetic subjects also had decreased leptin/BMI ratios (P<0.05 vs non-diabetic females). The log rank test identified age-adjusted correlation of plasma leptin concentration with sex (P<0.0004) and body mass index (P<0.0218), but not with glycosylated haemoglobin A1c (P>0.5) in all groups. Plasma leptin was correlated with age (P<0.0058) and serum triglycerides (P<0.0199) in type 1 diabetic patients, and with serum cholesterol (P<0.0059) and LDL (P<0.0013) in type 2 diabetic patients.


CONCLUSIONS
Defective leptin production and/or secretion might be present independently of metabolic control in female patients with type 1 or type 2 diabetes mellitus.
Roden
M
M
Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria. michael.roden@akh-wien.ac.at
Ludwig
C
C
Nowotny
P
P
Schneider
B
B
Clodi
M
M
Vierhapper
H
H
Roden
A
A
Waldhäusl
W
W
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D020738:Leptin; D014280:Triglycerides; D002784:Cholesterol