title: Common apolipoprotein A-IV variants are associated with differences in body mass index levels and percentage body fat.
abstract: OBJECTIVE
  To determine the relationship between two common apoA-IV variants (Thr347-->Ser; Gln360-->His), and body mass index (BMI) and percentage body fat.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Eight-hundred and forty-eight subjects screened for participation in ongoing clinical studies.
  
  
  METHODS
  ApoA-IV genotype, body mass index, waist-to-hip ratio and percentage body fat by bioelectric impedance.
  
  
  RESULTS
  Participants had an average age of 41+/-12 y and an average BMI of 28.2+/-5.5 kg/m2. Individuals homozygous for the Ser347 allele had higher BMI (32.3+/-6.6 vs 28.6+/-5.3 kg/m2; P<0.01) and percentage body fat (36.9+/-7.8 vs 31.0+/-9.6%; P<0.05) compared with individuals homozygous for Thr347. In contrast, the presence of at least one copy of the His360 allele was associated with lower BMI (27.2+/-5.0 vs 28.4+/-5.6 kg/m2; P<0.05) and percentage body fat (28.6+/-8.2 vs 30.7+/-9.1%; P<0.05). The genotype effects persisted after normalization of the data for the potential confounding effects of gender, age and race. When grouped by BMI percentile, the frequency of the Ser347/Ser347 genotype increased while the frequency of the His360 allele decreased with increasing BMI.
  
  
  CONCLUSIONS
  These data suggest a role for apoA-IV in fat storage or mobilization and that genetic variations in the apoA-IV gene may play a role in the development of obesity.
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, LA, USA. lefevrm@phs.pbrc.edu
authors.forename: M
authors.initials: M
authors.lastname: Lefevre
authors.forename: J C
authors.initials: JC
authors.lastname: Lovejoy
authors.forename: S M
authors.initials: SM
authors.lastname: DeFelice
authors.forename: J W
authors.initials: JW
authors.lastname: Keener
authors.forename: G A
authors.initials: GA
authors.lastname: Bray
authors.forename: D H
authors.initials: DH
authors.lastname: Ryan
authors.forename: D H
authors.initials: DH
authors.lastname: Hwang
authors.forename: F L
authors.initials: FL
authors.lastname: Greenway
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000368:Aged; D001054:Apolipoproteins A / Q000235:genetics*; D001823:Body Composition; D001824:Body Constitution; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D012044:Regression Analysis
chemical_list: D001054:Apolipoproteins A