title: Chin-Shan Community Cardiovascular Cohort in Taiwan-baseline data and five-year follow-up morbidity and mortality.
abstract: A cohort consisting of 3602 residents (82.8% of the target population) aged 35 years and older was established in 1990 in the Chin-Shan Community, a suburb 20 miles outside of metropolitan Taipei, Taiwan. The long-term objective was to investigate the prospective impact on cardiovascular health in a society undergoing transition from a developing to a developed nation. This article presents the study design, selected baseline risk factors of cardiovascular diseases (CVD), and CVD events at the 5-year follow-up evaluation with an emphasis on sociodemographic differences. The multivariate logistic regression analyses revealed that white-collar individuals were more likely than blue-collar workers to have dyslipidemia including high-density lipoprotein cholesterol (HDL-C) levels <35 mg/dl [odds ratio (OR) = 1.7, 95% confidence interval (CI) = 1.2-2.4] and low-density lipoprotein cholesterol (LDL-C) levels >/=160 mg/dl (OR = 1.3, 95% CI = 1.0-1.7). However, they were at slightly lower risk for stroke and CVD/sudden death, and at moderately higher risk for coronary artery disease and diabetes, although both these trends were not significant. Men were more likely than women to have HDL-C levels <35 mg/dl (OR = 1.8, 95% CI = 1.4-2.2), but they were less likely to have LDL-C levels >/=160 mg/dl (OR = 0.7, 95% CI = 0.6-0.8). The risk of CVD/sudden death was higher for men than for women during the follow-up period (OR = 1.9, 95% CI = 1.3-2.9). This could be due to risk factors such as a much higher prevalence of tobacco (61.9% vs. 4.5%) and alcohol (43.7% vs. 6.4%) use in men. In conclusion, individuals of higher socioeconomic status have a higher prevalence of dyslipidemia but slightly lower 5-year incidence of CVD events.
authors.affiliation: Department of Internal Medicine, National Taiwan University College of Medicine, 7 Chung-Shan South Road, 100, Taipei, Taiwan. ytlee@ha.mc.ntu.edu.tw
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
authors.forename: R S
authors.initials: RS
authors.lastname: Lin
authors.forename: F C
authors.initials: FC
authors.lastname: Sung
authors.forename: C
authors.initials: C
authors.lastname: Yang
authors.forename: K
authors.initials: K
authors.lastname: Chien
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Su
authors.forename: H
authors.initials: H
authors.lastname: Hsu
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000401:mortality*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003153:Community Health Services; D003906:Developing Countries; D005260:Female; D019456:Health Transition; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000401:mortality; D008019:Life Style; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012923:Social Class; D016019:Survival Analysis; D013624:Taiwan / Q000453:epidemiology
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL