title: SCORTEN: a severity-of-illness score for toxic epidermal necrolysis.
abstract: The mortality of toxic epidermal necrolysis is about 30%. Our purpose was to develop and validate a specific severity-of-illness score for cases of toxic epidermal necrolysis admitted to a specialized unit and to compare it with the Simplified Acute Physiology Score and a burn scoring system. A sample of 165 patients was used to develop the toxic epidermal necrolysis-specific severity-of-illness score and evaluate the other scores, a sample of 75 for validation. Model development used logistic regression equations that were translated into probability of hospital mortality; validation used measures of calibration and discrimination. We identified seven independent risk factors for death and constituted the toxic epidermal necrolysis-specific severity-of-illness score: age above 40 y, malignancy, tachycardia above 120 per min, initial percentage of epidermal detachment above 10%, serum urea above 10 mmol per liter, serum glucose above 14 mmol per liter, and bicarbonate below 20 mmol per liter. For each toxic epidermal necrolysis-specific severity-of-illness score point the odds ratio was 3.45 (confidence interval 2.26-5.25). Probability of death was: P(death) = elogit/1 + elogit with logit = -4.448 + 1.237 (toxic epidermal nec-rolysis-specific severity-of-illness score). Calibration demonstrated excellent agreement between expected (19. 6%) and actual (20%) mortality; discrimination was also excellent with a receiver operating characteristic area of 82%. The Simplified Acute Physiology Score and the burn score were also associated with mortality. The discriminatory powers were poorer (receiver operating characteristic area: 72 and 75%) and calibration of the Simplified Acute Physiology Score indicated a poor agreement between expected (9.1%) and actual (26.7%) mortality. This study demonstrates that the risk of death of toxic epidermal necrolysis patients can be accurately predicted by the toxic epidermal necrolysis-specific severity-of-illness score. The Simplified Acute Physiology Score and burn score appear to be less adequate.
authors.affiliation: Departments of Public Health and Dermatology, Hôpital Henri-Mondor (AP-HP), Université Paris XII, Créteil, France.
authors.forename: S
authors.initials: S
authors.lastname: Bastuji-Garin
authors.forename: N
authors.initials: N
authors.lastname: Fouchard
authors.forename: M
authors.initials: M
authors.lastname: Bertocchi
authors.forename: J C
authors.initials: JC
authors.lastname: Roujeau
authors.forename: J
authors.initials: J
authors.lastname: Revuz
authors.forename: P
authors.initials: P
authors.lastname: Wolkenstein
mesh_terms: D000368:Aged; D002056:Burns / Q000503:physiopathology; D005069:Evaluation Studies as Topic; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care / Q000379:methods; D011379:Prognosis; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000401:mortality / Q000503:physiopathology*