Propylthiouracil-induced antineutrophil cytoplasm antibody-positive anaphylactoid purpura-like vasculitis--a case report.
Propylthiouracil (PTU), a drug commonly used for treatment of hyperthyroidism, is associated with various rare side effects. Antineutrophil cytoplasm antibody (ANCA)-positive vasculitis is a relatively unusual complication among them. The pathogenesis of ANCA-positive vasculitis during PTU therapy is still obscure. We present the case of a 12-year-old boy who developed ANCA-positive vasculitis during PTU therapy for Graves' disease. His symptoms and signs were indistinguishable from anaphylactoid purpura, a common small-vessel vasculitis in children. The clinical manifestations improved after discontinuation of PTU and immunosuppressant treatment. He remained symptom-free at 11-months follow-up.
Wang
L H
LH
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Tsai
M J
MJ
Tsai
W Y
WY
Lee
J S
JS
Chiang
B L
BL
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D013956:Antithyroid Agents / Q000009:adverse effects*; D002648:Child; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D011695:IgA Vasculitis / Q000139:chemically induced*; D008297:Male; D011441:Propylthiouracil / Q000009:adverse effects*; D014657:Vasculitis / Q000139:chemically induced*
D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D011441:Propylthiouracil