title: HLA and beta-myosin heavy chain do not influence susceptibility to Chagas disease cardiomyopathy.
abstract: An inflammatory dilated cardiomyopathy occurs in 30% of Chagas' disease patients, chronically infected by Trypanosoma cruzi, while the remaining infected individuals are asymptomatic. Studies have indicated a role for genetic factors in the susceptibility to Chagas' disease cardiomyopathy. In an attempt to identify the genetic factors influencing the development and outcome of Chagas' cardiomyopathy, we compared the frequencies of alleles from two candidate gene loci, class II HLA and a microsatellite marker for the human cardiac beta-myosin heavy chain gene in different clinical groups. Patients were grouped as asymptomatic or with severe or mild cardiomyopathy. The results indicate that the HLA and myosin microsatellite allele profiles in all cardiomyopathy and in asymptomatic groups are similar. In conclusion, these results establish that polymorphism of HLA-DR and -DQ molecules, as well as beta-cardiac myosin, do not influence the susceptibility to different clinical forms of Chagas' disease or the progression to severe Chagas' cardiomyopathy. On the other hand, male sex was identified as a risk factor for progression to the more severe forms of cardiomyopathy (relative risk = 8.75).
authors.affiliation: Laboratory of Transplant Immunology, Heart Institute-InCor, School of Medicine, University of São Paulo, Brazil.
authors.forename: K C
authors.initials: KC
authors.lastname: Faé
authors.forename: S A
authors.initials: SA
authors.lastname: Drigo
authors.forename: E
authors.initials: E
authors.lastname: Cunha-Neto
authors.forename: B
authors.initials: B
authors.lastname: Ianni
authors.forename: C
authors.initials: C
authors.lastname: Mady
authors.forename: J
authors.initials: J
authors.lastname: Kalil
authors.forename: A C
authors.initials: AC
authors.lastname: Goldberg
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002598:Chagas Cardiomyopathy / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D004247:DNA / Q000032:analysis / Q000097:blood; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D018995:Myosin Heavy Chains / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012306:Risk; D012307:Risk Factors; D012737:Sex Factors; D014463:Ultrasonography
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D004247:DNA; D018995:Myosin Heavy Chains