title: Moderate alcohol consumption and changes in postprandial lipoproteins of premenopausal and postmenopausal women: a diet-controlled, randomized intervention study.
abstract: Moderate alcohol consumption is associated with a reduced risk of coronary heart disease. Earlier studies in men have shown that moderate alcohol consumption affects lipoprotein metabolism and hemostasis. In this diet-controlled, randomized, crossover trial, we investigated the effect on lipoprotein metabolism of moderate consumption of red wine or red grape juice with evening dinner for 3 weeks in premenopausal women using oral contraceptives and in postmenopausal women. After 3 weeks, blood samples were collected 1 hour before dinner up to 19 hours after starting dinner at 2-hour or 4-hour intervals. Plasma triglyceride concentrations and very low density lipoprotein (VLDL) triglyceride levels peaked 3 hours after dinner with wine in both premenopausal and postmenopausal women. After wine consumption, the overall high-density lipoprotein (HDL) cholesterol level was increased in postmenopausal women (mean increase 0.17 mmol/L, or 12%, p = 0.03), and the plasma low-density lipoprotein (LDL) cholesterol level was reduced in premenopausal women (mean reduction 0.35 mmol/L, or 12%, p = 0.01) as compared with grape juice consumption. The findings suggest that postprandial lipoprotein metabolism after moderate alcohol consumption differs between oral contraceptive-using premenopausal women and postmenopausal women. The response of postmenopausal women to alcohol resembled the response found in earlier studies in men.
authors.affiliation: Department of Nutritional Physiology, Organisation for Applied Scientific Research (TNO) Nutrition and Food Research Institute, Zeist, The Netherlands.
authors.forename: M S
authors.initials: MS
authors.lastname: van der Gaag
authors.forename: A
authors.initials: A
authors.lastname: Sierksma
authors.forename: G
authors.initials: G
authors.lastname: Schaafsma
authors.forename: A
authors.initials: A
authors.lastname: van Tol
authors.forename: T
authors.initials: T
authors.lastname: Geelhoed-Mieras
authors.forename: M
authors.initials: M
authors.lastname: Bakker
authors.forename: H F
authors.initials: HF
authors.lastname: Hendriks
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D003276:Contraceptives, Oral / Q000494:pharmacology; D018592:Cross-Over Studies; D004032:Diet; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D017698:Postmenopause; D019518:Postprandial Period; D017697:Premenopause
chemical_list: D003276:Contraceptives, Oral; D008074:Lipoproteins