title: Functions of peripheral 5-hydroxytryptamine receptors, especially 5-hydroxytryptamine4 receptor, in gastrointestinal motility.
abstract: The multiple 5-hydroxytryptamine (5-HT, serotonin) receptor subtypes are distinguished. In this article, we described mainly the 5-HT4 receptor of four subtypes of functional 5-HT receptors, 5-HT1, 5-HT2, 5-HT3, and 5-HT4, recognized in the gastrointestinal tract. In-vivo microdialysis experiments determined that activation of the 5-HT4 receptor stimulated intestinal motor activity associated with a local increase in acetylcholine (ACh) release from the intestinal cholinergic neurons in the whole body of dogs. The 5-HT4 receptor-mediated response of ACh release in the antral, corporal, and fundic strips isolated from guinea pig stomach corresponds to the presence of 5-HT4 receptor in the myenteric plexus. In-vitro receptor autoradiograms of the stomach and colon indicate that the distribution of 5-HT4 receptors in human tissues is similar to that in the guinea pig, although density of 5-HT4 receptors in the myenteric plexus of human tissues is lower than that in guinea pig tissues. The 5-HT4 receptors located in the myenteric plexus may participate in gastrointestinal motility, and thus the 5-HT4 agonists and antagonists may be available for treatment of dysfunction of gastrointestinal motility.
authors.affiliation: Department of Pharmacology, Nagasaki University School of Medicine, Sakamoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Taniyama
authors.forename: N
authors.initials: N
authors.lastname: Makimoto
authors.forename: A
authors.initials: A
authors.lastname: Furuichi
authors.forename: Y
authors.initials: Y
authors.lastname: Sakurai-Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Nagase
authors.forename: M
authors.initials: M
authors.lastname: Kaibara
authors.forename: T
authors.initials: T
authors.lastname: Kanematsu
mesh_terms: D000818:Animals; D004064:Digestive System / Q000378:metabolism*; D004068:Digestive System Physiological Phenomena; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D020033:Protein Isoforms; D011985:Receptors, Serotonin / Q000378:metabolism*; D044422:Receptors, Serotonin, 5-HT4; D015398:Signal Transduction
chemical_list: D020033:Protein Isoforms; D011985:Receptors, Serotonin; D044422:Receptors, Serotonin, 5-HT4