Potential diagnostic aids for abnormal fatty acid metabolism in a range of neurodevelopmental disorders.
Disorders of neurodevelopment include attention deficit hyperactivity disorder, dyspraxia, dyslexia and autism. There is considerable co-morbidity of these disorders and their identification often presents difficulties to those making a diagnosis. This is especially difficult when a multidisciplinary approach is not adopted. All of these disorders have been reported as associated with fatty acid abnormalities ranging from genetic abnormalities in the enzymes involved in phospholipid metabolism to symptoms reportedly improved following dietary supplementation with long chain fatty acids. If definitive disorders of lipid metabolism could be defined then the diagnosis and subsequent management of neurodevelopmental disorders might be transformed. In the identification of those disorders of development which involve lipid metabolism, there are now several tests, measures of lipid metabolism, which could be useful.
Ward
P E
PE
Highland Psychiatric Research Foundation, The Green House, Beechwood Business Park North, Inverness, UK. pauline.ward@quista.net
D001072:Apraxias / Q000175:diagnosis* / Q000378:metabolism*; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000378:metabolism; D001321:Autistic Disorder / Q000175:diagnosis / Q000378:metabolism; D015415:Biomarkers; D001944:Breath Tests; D002648:Child; D019587:Dietary Supplements; D004410:Dyslexia / Q000175:diagnosis / Q000378:metabolism; D005227:Fatty Acids / Q000097:blood / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis* / Q000378:metabolism*; D008661:Metabolism, Inborn Errors / Q000175:diagnosis / Q000378:metabolism; D009525:Niacin; D010741:Phospholipases A / Q000378:metabolism; D012559:Schizophrenia / Q000175:diagnosis / Q000378:metabolism
D015415:Biomarkers; D005227:Fatty Acids; D009525:Niacin; D010741:Phospholipases A