title: Persistent TT virus infection does not contribute to the development of non-A to -G hepatocellular carcinoma. A case-control study of 19 patients in Japan.
abstract: We tested the sera of patients with non-A, non-B, non-C, non-G (non-A to -G) hepatocellular carcinoma (HCC) for the presence of TT virus (TTV) DNA and clinicopathologically elucidated the relationship between TTV infection and hepatocarcinogenesis. The study cohort consisted of 19 patients with non-A to -G HCC. Detection of TTV DNA was performed by the nested polymerase chain reaction according to a previously published method. TTV DNA was detected in the sera of 9 (47.4%) of the 19 patients with non-A to -G HCC. The clinical background factors and blood biochemical parameters of the TTV-DNA-positive and -negative HCC patients did not significantly differ. Three TTV-DNA-positive and 2 TTV-DNA-negative patients underwent surgical resection of the HCC. The histological findings in the non-cancerous liver tissue of the TTV-DNA-positive and -negative patients did not significantly differ. In conclusion, TTV infection does not affect the features of non-A to -G HCC.
authors.affiliation: Third Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Moriyama
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Arakawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D016022:Case-Control Studies; D002908:Chronic Disease; D004266:DNA Virus Infections / Q000150:complications* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006518:Hepatitis Viruses; D022781:Hepatocytes / Q000502:physiology; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology / Q000821:virology; D008115:Liver Regeneration; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification*
chemical_list: D004279:DNA, Viral