Correlation of telomere lengths in normal and cancers tissue in the large bowel.
The hypothesis that telomeres in colorectal cancer cells exhibit age-related shortening, as in normal cells of the colorectal epithelium, was tested with samples of non-cancerous mucosa and cancer tissue from 124 patients (aged 29-97 years). Shortening with aging could be demonstrated for both normal and cancer tissues; regression analysis showed rates for length reduction of 44 and 50 base pair/year, respectively. Straight, essentially parallel, lines were obtained for the two cases, normal tissue values being about 2 kilobase pairs (kbp) higher, with a significant correlation between data at the individual patient level.
Nakamura
K
K
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, 32-5, Sakaecho Itabashi-ku, 173-0015, Tokyo, Japan. cpn@tmig.or.jp
Furugori
E
E
Esaki
Y
Y
Arai
T
T
Sawabe
M
M
Okayasu
I
I
Fujiwara
M
M
Kammori
M
M
Mafune
K
K
Kato
M
M
Oshimura
M
M
Sasajima
K
K
Takubo
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D004247:DNA / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000378:metabolism; D007420:Intestine, Large / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D016615:Telomere / Q000235:genetics*
D004273:DNA, Neoplasm; D004247:DNA