A steroid-binding protein mediates estrogen-dependent inhibition of growth of MCF-7 breast cancer cells.
We have described two different proteins that mediate MCF-7 cell growth inhibition (1). One is estrogen-dependent and is a heterodimer consisting of a heavy (54 kDa) and light (29 kDa) chain. This protein is distinct from cortisol-binding globulin (CBG), sex hormone-binding protein (SBP or SHBG) and albumin (HSA). It may be fetal steroid binding protein (FSBP). The other is not estrogen dependent, but may be related to the estrogen-dependent protein. Since these are large proteins they must be acting at the level of the plasma membrane, not traditional intracellular estrogen receptors, and inhibit MCF-7 cell growth.
Tanji
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Department of Environmental Health and Toxicology, School of Public Health, University at Albany, Rensselaer, New York 12144, USA.
Carpenter
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D001943:Breast Neoplasms / Q000473:pathology / Q000517:prevention & control*; D002352:Carrier Proteins / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005326:Fetal Proteins; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D012738:Sex Hormone-Binding Globulin / Q000502:physiology; D014407:Tumor Cells, Cultured
D002352:Carrier Proteins; D004967:Estrogens; D005326:Fetal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D012738:Sex Hormone-Binding Globulin; C027091:cortisol binding globulin; C051517:fetal steroid-binding protein, human