title: Parakeratosis variegata: a possible role of environmental hazards?
abstract: We report 2 cases of parakeratosis variegata (PV) evolving from lesions beginning with characteristics of ashy dermatosis. Both patients presented with a reticulated, poikilodermatous and hyperpigmented eruption with bizarre coalescent lichenoid papules. Histology showed lichenoid epidermotropic infiltrates, more pronounced in case No. 1, consistent with early malignancy. The course was chronic: after more than 10 years, systemic symptoms were not present. In patient No. 1, a monoclonal T-cell population was detected 12 years after the onset of the disease. Both patients had close contact with fertilizers and insecticides. In patient No. 2, the lesions spontaneously regressed within 3 years after cessation of exposure. PV may be a prelymphomatous stage of mycosis fungoides or some closely related cutaneous T-cell lymphoma and does not always evolve into overt malignancy. Gene rearrangement detection techniques may be helpful in predicting the course of the disease.
authors.affiliation: Department of Dermatology, Warsaw School of Medicine, Warsaw, Poland.
authors.forename: T T
authors.initials: TT
authors.lastname: Rogoziński
authors.forename: C
authors.initials: C
authors.lastname: Zekanowski
authors.forename: L
authors.initials: L
authors.lastname: Kaldan
authors.forename: M
authors.initials: M
authors.lastname: Blaszczyk
authors.forename: S
authors.initials: S
authors.lastname: Majewski
authors.forename: S
authors.initials: S
authors.lastname: Jablońska
mesh_terms: D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005308:Fertilizers / Q000009:adverse effects; D006801:Humans; D007306:Insecticides / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010267:Parapsoriasis / Q000209:etiology / Q000473:pathology*; D012867:Skin / Q000187:drug effects / Q000473:pathology*
chemical_list: D005308:Fertilizers; D007306:Insecticides