5-HT(1A) and 5-HT(7) receptor expression in the mammalian retina.
Serotonin or 5-hydroxytryptamine (5-HT) is a common neurotransmitter found widely in the nervous system. Here, using RT-PCR, we have identified both the 5-HT(1A) and 5-HT(7) receptor transcripts in the rabbit retina. Furthermore, we found the same two receptors in the rat retina which was previously believed not to have a serotoninergic system. These results confirm previous reports of 5-HT(7) gene expression in retina and together with other biochemical, physiological and anatomical studies, they support the presence of multiple 5-HT receptors in the mammalian retina and suggest that the action of serotonin in the retina may be more complicated than previously believed.
Pootanakit
K
K
Department of Biology, Boston College, Chestnut Hill, MA 02467, USA.
Brunken
W J
WJ
D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000378:metabolism*; D011817:Rabbits / Q000378:metabolism*; D051381:Rats / Q000378:metabolism*; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000235:genetics*; D044263:Receptors, Serotonin, 5-HT1; D012160:Retina / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D012333:RNA, Messenger; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; C104425:serotonin 7 receptor