Phantom materials for boron neutron capture therapy.
The aim of this work was to establish which reference phantom material is most suited for dosimetry under reference conditions of neutron beams for boron neutron capture therapy (BNCT). For this purpose, phantoms of dimensions 15 x 15 x 15 cm3 and 30 x 30 x 30 cm3, composed of water, tissue-equivalent (TE) liquid, polyethylene (PE), polymethyl methacrylate (PMMA) and water containing 10 microg g(-1) and 30 microg g(-1) 10B were irradiated using the Petten BNCT beam. Activation foils and a diode detector were used for the determination of the thermal neutron fluence rate. The gamma-ray dose rate and the fast neutron dose rate were determined using paired ionization chambers. In water, PMMA and TE liquid the absolute dose and fluence values agreed within 3% at a reference depth of 2 cm, with the exception of the gamma-ray dose rate in PMMA, which was 12% lower than in water. Due to a higher hydrogen concentration in PE compared with water, the dose and fluence values in PE differed more than 30% from those in water. Only minor differences were observed between the percentage depth dose curves for the various dose components in water, PMMA and TE liquid. The addition of 10 microg g(-1) and 30 microg g(-1) 10B to water resulted in a decrease in the absolute thermal neutron fluence at 2 cm depth of about 2% and 8%, respectively, and a decreased penetration of thermal neutrons at depth for the 30 microg g(-1) 10B concentration. For reference dosimetry of an epithermal neutron beam for BNCT, both water and TE liquid are suitable phantom materials. For practical reasons, water is therefore proposed as reference phantom material. For measurements requiring a solid phantom, PMMA is proposed. The lower gamma-ray dose in PMMA compared to water, however, needs to be taken into account.
Raaijmakers
C P
CP
The Netherlands Cancer Institute/Antoni van Leeuwenhoek Huis, Department of Radiotherapy, Amsterdam.
Nottelman
E L
EL
Mijnheer
B J
BJ
D001895:Boron / Q000627:therapeutic use; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D005720:Gamma Rays / Q000627:therapeutic use; D009502:Neutrons / Q000627:therapeutic use; D019047:Phantoms, Imaging; D020959:Polyethylene; D019904:Polymethyl Methacrylate; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D014867:Water
D014867:Water; D020959:Polyethylene; D019904:Polymethyl Methacrylate; D001895:Boron