title: Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinase.
abstract: Our understanding of the complex signal transduction pathways involved in signalling within cancer cells, between cancer cells and between cancer cells and their environment has increased dramatically in recent years. Here we concentrate on three non-receptor kinases: Src, focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI 3-kinase). These form part of a complex network of intracellular signals which is thought to be important in regulating cancer cells.
authors.affiliation: The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, G61 1BD, Glasgow, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Jones
authors.forename: V G
authors.initials: VG
authors.lastname: Brunton
authors.forename: M C
authors.initials: MC
authors.lastname: Frame
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D009363:Neoplasm Proteins / Q000737:chemistry / Q000502:physiology*; D009369:Neoplasms / Q000201:enzymology*; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D010744:Phosphoric Monoester Hydrolases / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D025521:Tumor Suppressor Proteins; D019061:src-Family Kinases / Q000737:chemistry / Q000502:physiology*
chemical_list: D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D019869:Phosphatidylinositol 3-Kinases; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human; D019061:src-Family Kinases; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human