title: Deprotonation of benzylic ethers using a hindered phosphazene base. A synthesis of benzofurans from ortho-substituted benzaldehydes.
abstract: The hindered nonionic phosphazene base P(4)-t-Bu efficiently deprotonates o-arylmethoxy benzaldehydes, leading to a direct synthesis of benzofurans. Strong ionic bases such as LDA, LiTMP, and KH failed.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. jverkade@iastate.edu
authors.forename: G A
authors.initials: GA
authors.lastname: Kraus
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: J G
authors.initials: JG
authors.lastname: Verkade
authors.forename: M
authors.initials: M
authors.lastname: Nagarajan
authors.forename: P B
authors.initials: PB
authors.lastname: Kisanga
mesh_terms: D001547:Benzaldehydes; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D009943:Organophosphorus Compounds
chemical_list: D001547:Benzaldehydes; D001572:Benzofurans; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds