Parasite proteomics.
Proteomics offers a new set of tools for investigating parasites and parasite-associated disease. In this article, John Barrett, Jim Jefferies and Peter Brophy describe the key technologies involved, including two-dimensional gel electrophoresis, image analysis, biological mass spectroscopy and database searching. The potential applications of proteomics in drug and vaccine discovery are reviewed, as are possible future developments.
Barrett
J
J
Institute of Biological Sciences, University of Wales, Aberystwyth, UK SY23 3DA. jzb@aber.ac.uk
Jefferies
J R
JR
Brophy
P M
PM
D015180:Electrophoresis, Gel, Two-Dimensional; D016678:Genome; D007091:Image Processing, Computer-Assisted; D013058:Mass Spectrometry; D010274:Parasitology / Q000379:methods*; D011506:Proteins / Q000032:analysis; D020543:Proteome
D011506:Proteins; D020543:Proteome