Technical, genetic, and ethical issues in screening and testing of African-Americans for hemochromatosis.
To define more precisely populations in which hemochromatosis is frequent to rare, problems of racial classification are introduced, with particular reference to Europeans and African-Americans. Because the category "Caucasian" includes a multitude of dissimilar peoples, the categories Europeans and European-Americans have been substituted for Caucasian, which is archaic. The background of discrimination in sickle hemoglobin programs for African-Americans are then analyzed, including, discrimination by employers, life insurance, and selective mandatory testing. Discrimination and selective testing of African-American employees of the Lawrence Livermore Laboratory continues today without prior consent, as it has since the 1970s. Dissimilarities between the genetics of hemochromatosis in Europeans and their descendants, Africans, and African-Americans are briefly analyzed. Finally, it is concluded that because hemochromatosis is unlike sickle hemoglobin in that it is potentially preventable and treatable, prevention and treatment principles should apply as in other diseases. Furthermore, because hemochromatosis is so common in European-Americans, discrimination, if practiced, would not be selective for African-Americans.
Bowman
J E
JE
Department of Pathology, and MacLean Center for Clinical Medical Ethics, The University of Chicago, IL 60615, USA. jbowman@midway.uchicago.edu
D001741:Black or African American; D004992:Ethics, Medical; D006432:Hemochromatosis / Q000175:diagnosis* / Q000208:ethnology / Q000235:genetics; D006801:Humans; D014481:United States