title: Pregnancy outcome in carriers of fragile X.
abstract: OBJECTIVE
  To evaluate pregnancy outcome in women who are carriers of fragile X.
  
  
  METHODS
  Cross-sectional case-control study.
  
  
  METHODS
  Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.
  
  
  METHODS
  Sixty-three singleton pregnancies in carriers of fragile X who were referred for genetic counselling and prenatal diagnosis to Kuopio University Hospital.
  
  
  METHODS
  Logistic regression analysis was used to compare pregnancy outcome in women who are fragile X carrier with outcome of the general obstetric population.
  
  
  RESULTS
  Carriers of fragile X often experienced more bleeding in late pregnancy than did the reference group. Otherwise, the course and outcome of pregnancy were comparable in both groups.
  
  
  CONCLUSIONS
  Pregnancy outcome in women who are carriers of fragile X is favourable. There is no need to initiate special fetal monitoring because of the fragile X status of the woman.
authors.affiliation: Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kallinen
authors.forename: K
authors.initials: K
authors.lastname: Korhonen
authors.forename: S
authors.initials: S
authors.lastname: Kortelainen
authors.forename: S
authors.initials: S
authors.lastname: Heinonen
authors.forename: M
authors.initials: M
authors.lastname: Ryynänen
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005600:Fragile X Syndrome / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D016015:Logistic Models; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D012307:Risk Factors; D014960:X Chromosome / Q000235:genetics*