Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1.
A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 microM.
Jeong
H W
HW
Korea Research Institute of Bioscience and Biotechnology, KIST, Taejon, South Korea.
Kim
M R
MR
Son
K H
KH
Han
M Y
MY
Ha
J H
JH
Garnier
M
M
Meijer
L
L
Kwon
B M
BM
D000818:Animals; D002934:Cinnamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019938:Cyclin D1 / Q000037:antagonists & inhibitors*; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007700:Kinetics; D015394:Molecular Structure; D011518:Proto-Oncogene Proteins
D002934:Cinnamates; D004791:Enzyme Inhibitors; D011518:Proto-Oncogene Proteins; C117045:p-hydroxycinnamaldehyde; D019938:Cyclin D1; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases