title: Determining the relative rates of change for prokaryotic and eukaryotic proteins with anciently duplicated paralogs.
abstract: The relative rates of change for eight sets of ubiquitous proteins were determined by a test in which anciently duplicated paralogs are used to root the universal tree and distances are calculated between each taxonomic group and the last common ancestor. The sets included ATPase subunits, elongation factors, signal recognition particle and its receptor, three sets of tRNA synthetases, transcarbamoylases, and an internal duplication in carbamoyl phosphate synthase. In each case phylogenetic trees were constructed and the distances determined for all pairs. Taken over the period of time since their last common ancestor, average evolutionary rates are remarkably similar for Bacteria and Eukarya, but Archaea exhibit a significantly slower average rate.
authors.affiliation: Center for Molecular Genetics, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0634, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Kollman
authors.forename: R F
authors.initials: RF
authors.lastname: Doolittle
mesh_terms: D000251:Adenosine Triphosphatases / Q000502:physiology; D000604:Amino Acyl-tRNA Synthetases / Q000502:physiology; D001221:Aspartate Carbamoyltransferase / Q000502:physiology; D001426:Bacterial Proteins / Q000502:physiology; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000502:physiology; D005057:Eukaryotic Cells / Q000502:physiology*; D019143:Evolution, Molecular; D020440:Gene Duplication; D009954:Ornithine Carbamoyltransferase / Q000502:physiology; D010445:Peptide Elongation Factors / Q000502:physiology; D010802:Phylogeny; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D018271:Signal Recognition Particle / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D010445:Peptide Elongation Factors; D011506:Proteins; D018271:Signal Recognition Particle; D001221:Aspartate Carbamoyltransferase; D009954:Ornithine Carbamoyltransferase; D000251:Adenosine Triphosphatases; D000604:Amino Acyl-tRNA Synthetases; D002222:Carbamoyl-Phosphate Synthase (Ammonia)