Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens.
The interaction between inhibitors of components of the fungal cell wall, glucan and chitin, was studied in vitro with the respective synthase enzyme inhibitors LY 303366 and nikkomycin Z. With Aspergillus fumigatus synergy was noted for inhibition and killing, and synergistic activity was also noted for some isolates of other species presently regarded as difficult to treat.
Stevens
D A
DA
Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose, California 95128, USA. stevens@leland.stanford.edu
D000617:Aminoglycosides; D000077612:Anidulafungin; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects; D002687:Chitin Synthase / Q000037:antagonists & inhibitors; D003045:Coccidioides / Q000187:drug effects; D004357:Drug Synergism; D054714:Echinocandins; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; D000077612:Anidulafungin; C011952:nikkomycin; D005964:Glucosyltransferases; C040232:glucan synthase; D002687:Chitin Synthase