[Pituitary development and pathology of transcription factors].
Over the last 10 years, important data on pituitary development have been reported using spontaneous or experimental models of gene inactivation. The development pathways of the anterior pituitary lobe include organogenesis resulting in Rathke pouch formation and cell differentiation. Pituitary development is controlled by sequential series of specific signaling molecules and specific transcription factors. In humans, inactivation of Pit-1, Prop-1, Rpx and Ptx2 genes is responsible for pituitary combined deficiency. In this paper, updated data on the embryology of the pituitary gland and the clinical phenotypes of inactivation of pituitary transcription factors are reported.
Barlier
A
A
Laboratoire ICNE-UMR 6544, Institut Jean-Roche, Faculté de Médecine Nord, Université de la Méditerranée, bd Pierre-Dramard, F13015 Marseille.
Vallette-Kasic
S
S
Manavela
M
M
Perez
M
M
Diaz
A
A
Pellegrini-Bouiller
I
I
Enjalbert
A
A
Brue
T
T
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics; D005314:Embryonic and Fetal Development; D020868:Gene Silencing; D018398:Homeodomain Proteins / Q000235:genetics; D008297:Male; D009154:Mutation; D009687:Nuclear Proteins; D010902:Pituitary Gland / Q000196:embryology*; D015398:Signal Transduction; D000072056:Transcription Factor HES-1; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000235:genetics*; D000097577:Homeobox Protein PITX2
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D000072056:Transcription Factor HES-1; D050817:Transcription Factor Pit-1; D014157:Transcription Factors; D000097577:Homeobox Protein PITX2; C489734:Hes1 protein, mouse; C102134:Prophet of Pit-1 protein