Functional suppression of long-term sustained response in the human hippocampal formation due to memory distraction.
Functional magnetic resonance imaging is used to investigate physiological dynamics in the human hippocampal formation due to memory distraction. A finger-movement task executed following a verbal memory task resulted in decreased verbal memory scores and shortening of active response in the hippocampal formation and the cerebellar dentate nucleus. Verbal rehearsal was excluded as an explanation because this sustained activation was approximately three-fold longer than the duration of the post-task activation observed in classical language processing regions such as Wernicke's and Broca's areas. These interference phenomena provide a physiological basis of memory distraction in the hippocampal formation.
Kato
T
T
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, 2021 6th street S.E., MN 55455, Minneapolis, USA. kato@cmrr.umn.edu
Ogawa
S
S
Ugurbil
K
K
D000328:Adult; D001288:Attention / Q000502:physiology*; D002529:Cerebellar Nuclei / Q000502:physiology*; D017352:Echo-Planar Imaging; D005260:Female; D005385:Fingers / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D009068:Movement / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology; D014706:Verbal Learning / Q000502:physiology*