title: Allergic reaction to gemfibrozil manifesting as eosinophilic gastroenteritis.
abstract: Eosinophilic gastroenteritis (EGE) is a rare condition of unknown etiology characterized by eosinophilic infiltration of the gastrointestinal (GI) tract. Previous associations with a drug or food allergy, allergic rhinitis, atopic dermatitis, and elevated IgE levels suggest an atopic predisposition in the pathogenesis of this disorder. Diagnostic criteria are GI symptoms, eosinophilic infiltration proven by biopsy of the GI tract, and absence of parasitic infection. We describe a case of EGE manifested as an allergy to gemfibrozil.
authors.affiliation: Department of Internal Medicine, William Beaumont Army Medical Center, El Paso, Texas, USA.
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
authors.forename: M V
authors.initials: MV
authors.lastname: Medellin
authors.forename: C
authors.initials: C
authors.lastname: Tumpkin
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001249:Asthma / Q000150:complications; D001706:Biopsy; D015984:Causality; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016145:Endoscopy, Digestive System; D004802:Eosinophilia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D004804:Eosinophils; D005260:Female; D005759:Gastroenteritis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D015248:Gemfibrozil / Q000009:adverse effects*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D007958:Leukocyte Count; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D012220:Rhinitis / Q000150:complications; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D000960:Hypolipidemic Agents; D015248:Gemfibrozil; D008775:Methylprednisolone