Predictive value of acetylcholine stimulation testing for oligohidrosis caused by zonisamide.
We studied 16 patients for whom zonisamide was newly prescribed. Acetylcholine stimulation testing was performed about 1 month after zonisamide was initiated. Oligohidrosis occurred in none of the four with a normal response and in four of the 12 with a decreased response. Acetylcholine stimulation testing predicted oligohidrosis with a sensitivity of 1 and a false-positive rate of 0.67. The acetylcholine stimulation test was sensitive in detecting oligohidrosis caused by zonisamide, although the false-positive rate was high.
Okumura
A
A
Department of Pediatrics, Nagoya University School of Medicine, Nagoya, Aichi, Japan.
Ishihara
N
N
Kato
T
T
Hayakawa
F
F
Kuno
K
K
Watanabe
K
K
D000109:Acetylcholine; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D018678:Cholinergic Agents; D004827:Epilepsy / Q000188:drug therapy*; D005189:False Positive Reactions; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D007007:Hypohidrosis / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology / Q000517:prevention & control*; D007555:Isoxazoles / Q000009:adverse effects*; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D013546:Sweating / Q000187:drug effects*; D016896:Treatment Outcome; D000078305:Zonisamide
D000927:Anticonvulsants; D018678:Cholinergic Agents; D007555:Isoxazoles; D000078305:Zonisamide; D000109:Acetylcholine