Outcome of invasive pneumococcal disease: a UK based study. Oxford Pneumococcal Surveillance Group.
METHODS
The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed.


RESULTS
The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials.


CONCLUSIONS
These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.
Shackley
F
F
Oxford Vaccine Group, University of Oxford, UK.
Knox
K
K
Morris
J B
JB
Crook
D
D
Griffiths
D
D
Mayon-White
R
R
George
R
R
Willocks
L
L
Moxon
E
E
D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011008:Pneumococcal Infections / Q000150:complications / Q000401:mortality*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013296:Streptococcus pneumoniae / Q000145:classification / Q000302:isolation & purification; D006113:United Kingdom / Q000453:epidemiology