title: Cytotoxity of non-alkaloidal taxane diterpenes from Taxus chinensis against a paclitaxel-resistant cell line.
abstract: Seven taxane diterpenes were isolated from the EtOH extract of the aerial parts of Taxus chinensis, and evaluated for cytotoxicity against nine human cell lines, including a beta-tublin mutant resistant to paclitaxel. Compound 2, a non-alkaloid-type taxane diterpene, showed significant cytotoxicity in most cell lines, and notably, equipotent against both parental and beta-tublin mutant tumor cell lines.
authors.affiliation: Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi- 739-8521, Hiroshima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukushima
authors.forename: N
authors.initials: N
authors.lastname: Fukamiya
authors.forename: M
authors.initials: M
authors.lastname: Okano
authors.forename: T
authors.initials: T
authors.lastname: Nehira
authors.forename: K
authors.initials: K
authors.lastname: Tagahara
authors.forename: S X
authors.initials: SX
authors.lastname: Zhang
authors.forename: D C
authors.initials: DC
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Tachibana
authors.forename: K F
authors.initials: KF
authors.lastname: Bastow
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D017239:Paclitaxel / Q000494:pharmacology*; D010946:Plants, Medicinal; D020946:Taxus / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
chemical_list: D004224:Diterpenes; D017239:Paclitaxel