Assignments of the tyrosinase related protein-1 and -2 genes to human chromosome bands 9p23 and 13q32.1 by in situ hybridization.
To determine the precise chromosomal localization of tyrosine related protein-1 and -2 (TRP-1 and TRP-2) genes by fluorescence in situ hybridization, we used DNAs isolated from human bacterial artificial chromosome clones. They contain genomic sequences with approximately 120 kb inserts for TRP-1 and TRP-2. The TRP-1 and TRP-2 genes were assigned to human chromosome bands 9p23 and 13q32.1, respectively. These results confirmed the previously mapped location for the TRP-1 gene and more precisely located the TRP-2 gene, which had previously been mapped to chromosome 13q31-q32.
Lee
Y M
YM
Institute for Medical Sciences, College of Natural Sciences, Ajou University, Suwon, Korea.
Ha
M J
MJ
Ryu
M S
MS
Moon
E
E
Im
S
S
Kim
H J
HJ
Kim
W
W
D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D015723:Gene Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D008562:Membrane Glycoproteins; D010088:Oxidoreductases; D011506:Proteins / Q000235:genetics*
D008562:Membrane Glycoproteins; D011506:Proteins; D010088:Oxidoreductases; C489799:TYRP1 protein, human; C064056:tyrosinase-related protein-1; D019746:Intramolecular Oxidoreductases; C042501:dopachrome isomerase