title: Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B.
abstract: An efficient new process is described for the synthesis of ecteinascidin ET-743 (1) and phthalascidin (2), starting from readily available cyanosafracin B (3).
authors.affiliation: Pharma Mar, S. A. C/ de la Calera 3, 28760-Tres Cantos, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Cuevas
authors.forename: M
authors.initials: M
authors.lastname: Pérez
authors.forename: M J
authors.initials: MJ
authors.lastname: Martín
authors.forename: J L
authors.initials: JL
authors.lastname: Chicharro
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Rivas
authors.forename: M
authors.initials: M
authors.lastname: Flores
authors.forename: A
authors.initials: A
authors.lastname: Francesch
authors.forename: P
authors.initials: P
authors.lastname: Gallego
authors.forename: M
authors.initials: M
authors.lastname: Zarzuelo
authors.forename: F
authors.initials: F
authors.lastname: de La Calle
authors.forename: J
authors.initials: J
authors.lastname: García
authors.forename: C
authors.initials: C
authors.lastname: Polanco
authors.forename: I
authors.initials: I
authors.lastname: Rodríguez
authors.forename: I
authors.initials: I
authors.lastname: Manzanares
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000737:chemistry; D001392:Azocines; D004149:Dioxoles / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry; D011809:Quinones; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin
chemical_list: D018906:Antineoplastic Agents, Alkylating; D001392:Azocines; D004149:Dioxoles; D007202:Indicators and Reagents; D007546:Isoquinolines; D010797:Phthalimides; D011809:Quinones; D044005:Tetrahydroisoquinolines; C413208:cyanosafracin B; C118707:phthalascidin; D000077606:Trabectedin