title: Osteoporotic fractures at presentation of Cushing's disease: two case reports and a literature review.
abstract: Osteoporosis is a common complication of Cushing's disease/syndrome. Fractures can be the presenting manifestation. We report two cases and review 28 others from the literature. Clinical, laboratory, and absorptiometry data are reviewed; the vertebrae and ribs were the most common fracture sites, and osteoporosis reversal after treatment varied with age, gender, and symptom duration. The pathophysiology, which remains controversial, is discussed. A search for Cushing's disease/syndrome should be part of the routine evaluation of osteoporosis in children and adults, particularly men.
authors.affiliation: Rheumatology Department, Sud-Francilien Hospital Center, Corbeil-Essonnes, France.
authors.forename: V
authors.initials: V
authors.lastname: Khanine
authors.forename: J J
authors.initials: JJ
authors.lastname: Fournier
authors.forename: E
authors.initials: E
authors.lastname: Requeda
authors.forename: J P
authors.initials: JP
authors.lastname: Luton
authors.forename: F
authors.initials: F
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Crouzet
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D019386:Alendronate / Q000627:therapeutic use; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D003480:Cushing Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D019386:Alendronate