title: Differentiation-inducing effect of magnolialide, a 1 beta-hydroxyeudesmanolide isolated from Cichorium intybus, on human leukemia cells.
abstract: Cichorium intybus contains two 1beta-hydroxyeudesmanolides, magnolialide and artesin, together with several constituents. Magnolialide inhibits the growth of several tumor cell lines and appears to induce differentiation of human leukemia HL-60 and U-937 cells to monocyte/macrophage-like cells. Another 1beta-hydroxyeudesmanolide, artesin, and other constituents were inactive. The content of magnolialide was shown to be highest in the leaves of Inje cultivar among the cultivars investigated in this study.
authors.affiliation: College of Pharmacy, Kyung-Hee University, Seoul, Korea.
authors.forename: K T
authors.initials: KT
authors.lastname: Lee
authors.forename: J I
authors.initials: JI
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Park
authors.forename: K O
authors.initials: KO
authors.lastname: Yoo
authors.forename: Y N
authors.initials: YN
authors.lastname: Han
authors.forename: K
authors.initials: K
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D018651:Cichorium intybus / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D007938:Leukemia / Q000473:pathology*; D051379:Mice; D012717:Sesquiterpenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D007783:Lactones; D012717:Sesquiterpenes; C417229:magnolialide