[Effect of domestic glutathione on the alcoholic liver disease].
OBJECTIVE
To evaluate the effect and safety of domestic glutathione (GSH) on serum ALT, AST, SB levels in alcoholic liver disease (ALD) by multicenter, randomized and TAD controlled trial.


METHODS
All the 110 patients with ALD enrolled had a history of drinking over 80g-120g daily for 5 years, and were randomized either into GSH (continuous infusion of 600g daily for 30d) or TAD (with the same dosage, course and route as GSH) group. The efficacy and safery were evaluated with clinical and biochemical (ALT, AST and GGT) parameters.


RESULTS
After 8 weeks of treatment, the clinical signs were improved at a different degree in both groups. ALT, AST and SB showed no significant difference in the two groups (the efficacy rate of 93% vs 96%, P>0.05).


CONCLUSIONS
The domestic GSH, with a good tolerance and safety, has a sound efficacy in the improvement of clinical signs and hepatic functions.
Zhang
Q
Q
The Liver Diseace Center of Second Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China.
Guo
S
S
Hu
D
D
He
N
N
Zhang
J
J
Zhong
S
S
Chen
Y
Y
Zhang
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005978:Glutathione / Q000627:therapeutic use*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D005978:Glutathione