title: Osteoradionecrosis of the maxillary-orbital complex after neutron beam radiotherapy.
abstract: OBJECTIVE
  Neutron beam radiotherapy (NRT) has been advocated for treatment of malignant salivary gland tumors and adenoid cystic carcinoma of the paranasal sinuses. The purpose of this study is to determine whether primary or adjuvant NRT results in a significantly increased rate of osteora-dionecrosis (ORN) of the maxillary-orbital complex (MOC).
  
  
  METHODS
  All patients who received primary or adjuvant NRT involving the MOC and/or maxillofacial prosthetic rehabilitation at Wayne State University from 1992 to 1997 were evaluated (n = 9).
  
  
  RESULTS
  ORN did not develop in any of the 5 patients who received primary NRT. All 4 patients who received adjuvant NRT after surgical resection had ORN involving the MOC within the irradiated fields.
  
  
  CONCLUSIONS
  The reported trend of ORN after definitive surgery and NRT shows a markedly increased complication rate.
  
  
  CONCLUSIONS
  The use of adjuvant NRT after definitive surgical resection involving the MOC should be considered with great caution.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Marunick
authors.forename: S J
authors.initials: SJ
authors.lastname: Bahu
authors.forename: A
authors.initials: A
authors.lastname: Aref
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008439:Maxillary Diseases / Q000209:etiology*; D008441:Maxillary Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D009916:Orbital Diseases / Q000209:etiology*; D009918:Orbital Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D010025:Osteoradionecrosis / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012189:Retrospective Studies