title: Gastric emptying rate of solids is reduced in a group of ileostomy patients.
abstract: Feedback inhibition from the colon acts as a potent inhibitor of gastrointestinal motility via an array of gut peptides and neural pathways. The effect of total colonectomy on gastric emptying was assessed in five healthy ileostomy patients (<5 cm ileal resection) and five matched controls. Each subject consumed two isoenergetic test meals of contrasting fat-carbohydrate ratio in random order. Emptying of solids was measured using the [13C]octanoic acid breath test, and liquid emptying was assessed after oral dosing with paracetamol. Ileostomist subjects exhibited an increased half-emptying time for solids (P = 0.047), which included components of an increased gastric lag time (P = 0.004) and a reduction in the linear emptying rate (P = 0.003). There was no difference in the pattern of liquid emptying between subject groups. In conclusion, the gastric emptying rate of solids was reduced in ileostomy patients compared with controls.
authors.affiliation: Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle-upon-Tyne, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Robertson
authors.forename: J C
authors.initials: JC
authors.lastname: Mathers
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000378:metabolism / Q000601:surgery; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D005260:Female; D005746:Gastric Emptying; D006801:Humans; D007081:Ileostomy; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012016:Reference Values
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats