Effect of diet on haemoglobin adducts from 4-aminobiphenyl in rats.
High levels of haemoglobin (Hb) adducts from 4-aminobiphenyl (4-ABP), a proven human carcinogen, have been reported in untreated animals from different laboratories fed various commercial standard diets. Therefore, the impact of dietary modifications on 4-ABP Hb adducts was investigated. Female Sprague-Dawley rats were fed a regular standard diet or three different test diets for 4 weeks. 4-ABP Hb adducts were significantly lower in rats on vegetable-based test diets #2 (596+/-183 pg/g Hb, P = 0.028) and #3 (537+/-48 pg/g Hb, P = 0.009) compared with controls (974+/-154 pg/g Hb). Cereal-based test diet #1 (1080+/-388 pg/g Hb) had no influence on the basal Hb adduct levels determined before the start of the experiment (1054+/-163 pg/g Hb). In conclusion, the body burden of rats with 4-ABP could be significantly reduced by dietary modifications.
Richter
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E
Walther Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität München, Munich, Germany. franky.richter@lrz.uni-muenchen.de
Rösler
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S
Becker
A
A
D000611:Aminobiphenyl Compounds / Q000097:blood* / Q000633:toxicity; D000818:Animals; D001822:Body Burden; D001835:Body Weight / Q000502:physiology; D002273:Carcinogens / Q000378:metabolism* / Q000633:toxicity; D004032:Diet; D002523:Edible Grain; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014675:Vegetables
D000611:Aminobiphenyl Compounds; D002273:Carcinogens; D006454:Hemoglobins; C006757:4-biphenylamine