Metabolizing enzyme genotype and risk for upper aerodigestive tract cancer.
Genetic polymorphisms are associated with a number of enzymes involved in the metabolism of carcinogens important in the induction of upper aerodigestive tract cancer. It has been suggested that such polymorphisms may be linked to cancer susceptibility. Using a case-control molecular epidemiologic approach, the association between many of these genetic polymorphisms and susceptibility to upper aerodigestive tract cancer has been investigated in numerous studies. In this review, we summarize the findings of these studies, analyzing potential associations with upper aerodigestive tract cancer risk in terms of gene:environment interactions, genotype-induced functional defects in enzyme activity and/or expression, and the influence of race on these associations.
Lazarus
P
P
H. Lee Moffitt Cancer Center, Divisions of Cancer Control and Molecular Oncology, University of South Florida, MRC-2E, 12902 Magnolia Drive, Tampa, FL 33612, USA. plazarus@moffitt.usf.edu
Park
J Y
JY
D002273:Carcinogens / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000208:ethnology*; D005982:Glutathione Transferase / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000201:enzymology*; D006801:Humans; D007564:Japan / Q000208:ethnology; D009363:Neoplasm Proteins / Q000235:genetics*; D009602:Nitrosamines / Q000378:metabolism; D010947:Plants, Toxic; D011084:Polycyclic Aromatic Hydrocarbons / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics; D013624:Taiwan / Q000208:ethnology; D014026:Nicotiana / Q000737:chemistry
D002273:Carcinogens; D009363:Neoplasm Proteins; D009602:Nitrosamines; D011084:Polycyclic Aromatic Hydrocarbons; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase