title: Functional outcome of transplanted knee joints in dogs.
abstract: Total knee joint transplantation has been performed in animal models and humans. This study investigates the impact of this operation on knee joint function in a dog model. Therefore, replantation was compared to transplantation during a 6-month follow-up period in four dogs in each group. The peak vertical ground reaction force normalized in all legs undergoing replantation and in two of four after transplantation. A third transplant recipient reduced loading from the 4th month due to a local complication, and the fourth succumbed to sepsis 3 months postoperatively. A weight-bearing index (WBI), defined as loading of the grafted divided by loading of both hind-limbs decreased from 0.48 +/- 0.08 preoperatively to 0.13 +/- 0.10 by 1 month after replantation and from 0.53 +/- 0.07 to 0 after transplantation. After 6 months, weight-bearing of all replant recipients was restored, but reduced in two transplant recipients with graft function. Full recovery after replantation, but impaired function after transplantation, was also reflected in the histological results: normal histological pictures of blood vessels, cartilage, bone and soft tissues were found in all replant recipients, but infiltrative vasculopathy indicating chronic rejection was found in the transplanted joints. The results of this animal study confirm that the procedure can lead to satisfactory functional results but also emphasize the need for perfect control of immunosuppression.
authors.affiliation: Department of Orthopaedic Surgery, University of Basel, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Schäfer
authors.forename: R
authors.initials: R
authors.lastname: Rosso
authors.forename: R
authors.initials: R
authors.lastname: Fricker
authors.forename: G
authors.initials: G
authors.lastname: Spagnoli
authors.forename: G
authors.initials: G
authors.lastname: Jundt
authors.forename: H
authors.initials: H
authors.lastname: Gerber
authors.forename: M
authors.initials: M
authors.lastname: Heberer
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D016572:Cyclosporine / Q000494:pharmacology; D004285:Dogs; D005260:Female; D006084:Graft Rejection / Q000473:pathology / Q000503:physiopathology; D007596:Joints / Q000473:pathology / Q000637:transplantation*; D007719:Knee Joint / Q000473:pathology / Q000503:physiopathology; D008124:Locomotion / Q000502:physiology*; D008297:Male; D011183:Postoperative Complications / Q000473:pathology / Q000503:physiopathology*; D016059:Range of Motion, Articular / Q000502:physiology*; D016474:Weight-Bearing / Q000502:physiology*
chemical_list: D016572:Cyclosporine