Activities of antimicrobial agents against intracellular pneumococci.
Pneumococci can enter and survive inside human lung alveolar carcinoma cells. We examined the activity of azithromycin, gentamicin, levofloxacin, moxifloxacin, penicillin G, rifampin, telithromycin, and trovafloxacin against pneumococci inside and outside cells. We found that moxifloxacin, trovafloxacin, and telithromycin were the most active, but only telithromycin killed all intracellular organisms.
Mandell
G L
GL
Division of Infectious Diseases, University of Virginia Health Systems, Charlottesville 22908, USA. gm@virginia.edu
Coleman
E J
EJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds; D017963:Azithromycin / Q000494:pharmacology; D024841:Fluoroquinolones; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D048628:Ketolides; D064704:Levofloxacin; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009287:Naphthyridines / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D010400:Penicillin G / Q000494:pharmacology; D011804:Quinolines; D012293:Rifampin / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D005839:Gentamicins; D048628:Ketolides; D018942:Macrolides; D009287:Naphthyridines; D011804:Quinolines; D064704:Levofloxacin; D017963:Azithromycin; C080163:trovafloxacin; D015242:Ofloxacin; C106791:telithromycin; D010400:Penicillin G; D000077266:Moxifloxacin; D012293:Rifampin