Effect of sodium nitroprusside on mouse sperm migration in vitro.
In the present study the effect of sodium nitroprusside, a nitric oxide releaser, on mouse sperm motion behavior was examined. The number of sperm migrating in experimental plate to medium containing sodium nitroprusside in concentration 50 nM was significantly higher than the number migrating to control. This effect was observed after 3 and 5 h of incubation, and it was not time dependent. The presence of sodium nitroprusside in higher concentrations did not cause any visible changes or decrease the migration of sperm. These effects were interpreted as chemokinesis but not chemotaxis of sperm induced by influence of sodium nitroprusside on sperm metabolism and motility.
Sliwa
L
L
Department of Biology, Jagiellonian University School of Medicine, Kraków, Poland.
Stochmal
E
E
D000818:Animals; D002633:Chemotaxis / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology*; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects*
D020030:Nitric Oxide Donors; D009599:Nitroprusside