3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1H)-pyridinone: potent inhibitors of lipid peroxidation and cell toxicity.
Bebbington
D
D
Department of Chemistry, Cerebrus, Winnersh, Wokingham, UK. david_bebbington@vpharm.com
Monck
N J
NJ
Gaur
S
S
Palmer
A M
AM
Benwell
K
K
Harvey
V
V
Malcolm
C S
CS
Porter
R H
RH
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007461:Iodoacetates; D015227:Lipid Peroxidation / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D000975:Antioxidants; D016166:Free Radical Scavengers; D007461:Iodoacetates; D018696:Neuroprotective Agents; D011728:Pyridones; C412727:CEB 1370