Genital lichen sclerosus associated with morphoea or systemic sclerosis: clinical and HLA characteristics.
Although patients with both morphoea and lichen sclerosus have been reported previously, in the majority of these reports the lichen sclerosus has been extragenital. We report nine patients in whom genital lichen sclerosus coexisted with scleroderma spectrum disorders including seven with morphoea, one with morphoea and lichen planus, and one with systemic sclerosis. The clinical features, associated autoimmune disease, autoantibodies and HLA type are reported. Antibodies to Borrelia burgdorferi were not detected in any of the patients. The coexistence of these diseases raises a number of intriguing questions about the relationship between them.
Farrell
A M
AM
Department of Dermatology, Oxford Radcliffe Hospitals, Oxford OX3 7LJ, U.K.
Marren
P M
PM
Wojnarowska
F
F
D000368:Aged; D000907:Antibodies, Bacterial / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications; D015748:Borrelia burgdorferi Group / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D008010:Lichen Planus / Q000150:complications* / Q000276:immunology; D018459:Lichen Sclerosus et Atrophicus / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000150:complications* / Q000276:immunology; D012594:Scleroderma, Localized / Q000150:complications* / Q000276:immunology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000276:immunology; D014845:Vulvar Diseases / Q000150:complications* / Q000276:immunology
D000907:Antibodies, Bacterial; D001323:Autoantibodies