title: The human transmissible spongiform encephalopathies (TSEs): implications for dental practitioners.
abstract: Transmissible spongiform encephalopathies (TSEs) are rare, fatal degenerative brain diseases which affect humans and certain animals, and are caused by inheritance or acquisition of prions (PrPs). Inherited TSEs include Fatal Familial Insomnia (FFI), Gerstmann-Straussler-Scheinker syndrome (GSS) and other less well clinically characterised disorders, while the human infective TSEs include sporadic, iatrogenic and variant Creutzfeldt-Jakob disease (vCJD). The causative prions are found especially in neural tissues and spinal fluid, and in the case of vCJD, in lymphoreticular tissue. Available epidemiological evidence suggests that normal social or routine clinical contact with affected patients does not present a risk to health care workers, relatives or the community. Isolation of patients is not considered necessary. Nevertheless as the prions are resistant to conventional chemical, irradiation and heat sterilisation methods, highly specific cross-infection control measures are required for the dental management of patients with, or at notable risk, of TSE. The present article reviews current knowledge of the clinical consequences of prion disease and provides information regarding necessary changes to the cross-infection routine when managing patients infected, or at risk of, prion disease.
authors.affiliation: Eastman Dental Institute for Oral Health Care Sciences, University College London, University of London. S.Porter@eastman.ucl.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Porter
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: G L
authors.initials: GL
authors.lastname: Ridgway
authors.forename: J
authors.initials: J
authors.lastname: Bell
mesh_terms: D000818:Animals; D002417:Cattle; D019551:Dental Disinfectants / Q000494:pharmacology; D003762:Dental Instruments; D004866:Equipment Contamination / Q000517:prevention & control; D006801:Humans; D019552:Infection Control, Dental; D017096:Prion Diseases / Q000517:prevention & control* / Q000635:transmission; D011328:Prions / Q000187:drug effects; D012307:Risk Factors; D012756:Sheep; D012973:Sodium Hypochlorite / Q000494:pharmacology; D013242:Sterilization / Q000379:methods
chemical_list: D019551:Dental Disinfectants; D011328:Prions; D012973:Sodium Hypochlorite