CD7 delivers a pro-apoptotic signal during galectin-1-induced T cell death.
Galectin-1, an endogenous lectin expressed in lymphoid organs and immune-privileged sites, induces death of human and murine thymocytes and T cells. Galectin-1 binds to several glycoproteins on the T cell surface, including CD7. However, the T cell surface glycoprotein receptors responsible for delivering the galectin-1 death signal have not been identified. We show that CD7 is required for galectin-1-mediated death. This demonstrates a novel function for CD7 as a death trigger and identifies galectin-1/CD7 as a new biologic death signaling pair.
Pace
K E
KE
Department of Pathology and Laboratory Medicine, University of California School of Medicine, Los Angeles, CA 90095, USA.
Hahn
H P
HP
Pang
M
M
Nguyen
J T
JT
Baum
L G
LG
D000276:Adjuvants, Immunologic / Q000502:physiology*; D019011:Antigens, CD7 / Q000502:physiology*; D017209:Apoptosis / Q000276:immunology*; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D016923:Cell Death / Q000276:immunology; D002460:Cell Line; D037483:Galectin 1; D006388:Hemagglutinins / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D007424:Intracellular Fluid / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D014407:Tumor Cells, Cultured
D000276:Adjuvants, Immunologic; D019011:Antigens, CD7; D037483:Galectin 1; D006388:Hemagglutinins; D002118:Calcium