Signaling pathways of the acute hypoxic ventilatory response in the nucleus tractus solitarius.
The nucleus tractus solitarii (nTS) provides the initial central synaptic relay to peripheral chemoreceptor afferent inputs elicited by changes in oxygen tension. Insofar, the overall cumulative evidence pointing towards the N-methyl-D-aspartate (NMDA) glutamate receptor as the critical receptor underlying the early component of the hypoxic ventilatory response (HVR) is reviewed in detail. In addition, we will present recent findings supporting a role for platelet-derived growth factor (PDGF) beta receptor activation in modulation of the late phase of HVR. This evidence underscores the proposal of a working model for intracellular signaling pathways, downstream to the NMDA glutamate and PDGF-beta receptors in nTS neurons, which may contribute to both the ventilatory characteristics of the acute hypoxic response and to subsequently occurring functional adaptations and synaptic plasticity phenomena.
Gozal
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D
Department of Pediatrics, Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, 570 S. Preston Street, Ste. 321, Louisville, KY 40202, USA. d0goza01@gwise.louisville.edu
Gozal
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E
Simakajornboon
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N
D000208:Acute Disease; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008954:Models, Biological; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011493:Protein Kinase C / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology; D012143:Respiratory Physiological Phenomena; D015398:Signal Transduction; D017552:Solitary Nucleus / Q000503:physiopathology*
D016194:Receptors, N-Methyl-D-Aspartate; D019001:Nitric Oxide Synthase; D017479:Receptors, Platelet-Derived Growth Factor; D011493:Protein Kinase C