Control of catecholamine release and blood pressure with octreotide in a patient with pheochromocytoma: a case report with in vitro studies.
A 65-year-old male patient with pheochromocytoma, whose hypertensive episodes were uncontrolled using conventional therapy, was successfully treated with octreotide (SMS 201-995). The serum catecholamine level and the urinary excretion of catecholamines decreased after 300 microgram/day of octreotide was administered. To clarify the mechanisms of octreotide that lower catecholamine released from a tumor, we studied the in vitro effects of octreotide on membrane potentials and voltage-dependent Ca(2+) channel (VDCC) current using the whole-cell patch-clamp technique in single pheochromocytoma cells dispersed after tumor resection. The action potentials were reversibly inhibited with 10 microM octreotide. In addition, the VDCC current evoked by depolarized pulses from the holding potential of -60 mV was inhibited with 10 microM octreotide. Octreotide is useful for controlling blood pressure before surgery in some patients with uncontrolled hypertension caused by a pheochromocytoma.
Koriyama
N
N
First Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
Kakei
M
M
Yaekura
K
K
Okui
H
H
Yamashita
T
T
Nishimura
H
H
Matsushita
S
S
Tei
C
C
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology*; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D015220:Calcium Channels / Q000187:drug effects; D002395:Catecholamines / Q000378:metabolism* / Q000652:urine; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D015282:Octreotide / Q000627:therapeutic use*; D018408:Patch-Clamp Techniques; D010673:Pheochromocytoma / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology*
D015220:Calcium Channels; D002395:Catecholamines; D006728:Hormones; D015282:Octreotide