Selective deprotection of acetals with Me3SiCH2MgCl. Peterson-type olefination of acetals
By employing the chelation strategy, treatment of an acetal of a contiguous diol with Me3SiCH2MgCl liberates the corresponding diol regioselectively. In addition, acetals of different structural variety are transformed upon treatment with Me3SiCH2MgCl and ZnI2 into the corresponding olefination products in good yield.
Chiang
CC
Department of Chemistry, National Taiwan University, Taipei.
Chen
YH
Hsieh
YT
Luh
TY