[Hypertension and altered cardiovascular variability associated with obstructive sleep apnea].
In the past 5 years several epidemiologic studies have demonstrated that sleep-related breathing disorders are an independent risk factor for hypertension, probably resulting from a combination of repetitive episodes of hypoxia, hypercapnea, arousals, and a striking surge in sympathetic excitation, and altered baroreflex control during sleep. Obstructive sleep apnea (OSA) may lead to the cardiac arrhythmias and myocardial ischemia and it is a possible risk factor for stroke. We confirmed that nasal CPAP has been shown to lower blood pressure in some hypertensive OSA patients. Early recognition and treatment of sleep-apnea may improve cardiovascular function.
Otsuka
K
K
Tokyo Women's Medical University, School of Medicine, Daini Hospital, Department of Medicine.
D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D011175:Positive-Pressure Respiration; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000628:therapy