Prognostic value of bcl-2, p53 and Ki-67 in invasive squamous carcinoma of the uterine cervix.
The aim of this study was to evaluate the immunohistochemical expression of the markers bcl-2, p53 and Ki67 and their relation to the classical clinical-pathological prognostic factors in invasive squamous cellular carcinoma of the cervix. Since bcl-2 and p53 are implicated in the regulation of programmed cell death, very probably they play a role in carcinogenesis and consequently become prognostic factors.
Padovan
P
P
Gynecology Institute, Padua University, Italy.
Salmaso
R
R
Marchetti
M
M
Padovan
R
R
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000401:mortality; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008875:Middle Aged; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000401:mortality
D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53