title: DNA photolyases and cryptochromes.
abstract: This brief review gives an overview of the gene family of photolyases and cryptochromes, followed by a description of the main features of the three-dimensional structures of photolyases known to date. It then discusses recent biophysical studies of photolyase function, and modelling studies on the interaction between the enzyme and its substrate.
authors.affiliation: Howard Hughes Medical Institute and University of Texas Southwestern, Medical Center, Dallas, TX 75390-9050, USA. johann.deisenhofer@email.swmed.edu
authors.forename: J
authors.initials: J
authors.lastname: Deisenhofer
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000201:enzymology / Q000235:genetics; D029681:Arabidopsis Proteins; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D056931:Cryptochromes; D000458:Cyanobacteria / Q000201:enzymology; D004249:DNA Damage; D004260:DNA Repair; D004255:Deoxyribodipyrimidine Photo-Lyase / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D005136:Eye Proteins; D005182:Flavin-Adenine Dinucleotide / Q000737:chemistry; D005420:Flavoproteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D046911:Macromolecular Substances; D008958:Models, Molecular; D005810:Multigene Family; D017956:Photoreceptor Cells, Invertebrate; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011740:Pyrimidine Dimers / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013763:Tetrahydrofolates / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D001426:Bacterial Proteins; C538962:CRY1 protein, Arabidopsis; D056931:Cryptochromes; D029721:Drosophila Proteins; D005136:Eye Proteins; D005420:Flavoproteins; D019476:Insect Proteins; D046911:Macromolecular Substances; D010940:Plant Proteins; D011740:Pyrimidine Dimers; D043562:Receptors, G-Protein-Coupled; D013763:Tetrahydrofolates; C119828:cry protein, Drosophila; C013123:5,10-methylenetetrahydrofolic acid; D005182:Flavin-Adenine Dinucleotide; D004255:Deoxyribodipyrimidine Photo-Lyase