title: The 4G/4G genotype at nucleotide position -675 in the promotor region of the plasminogen activator inhibitor 1 (PAI-1) gene is less frequent in young patients with minor stroke than in controls.
abstract: Genetic risk factors play an important role in the aetiology of vascular diseases. The insertion/deletion polymorphism (4G/5G) in the promotor region of the plasminogen activator inhibitor 1 (PAI-1) gene has been associated with an increased risk of myocardial infarction. We investigated 136 patients with minor stroke (MS) and transient ischaemic attack (TIA) and found a prevalence of 0.32 for the 4G/4G genotype in patients compared with 0.42 in 115 age-matched healthy controls. The 4G/4G genotype was significantly less frequent among 61 patients symptomatic before the age of 60 years (prevalence 0.20) than in 75 patients symptomatic after 60 years of age (prevalence 0.42; odds ratio). Our results indicate that the 4G/4G genotype is not a risk factor for MS or TIA and may even be protective in young patients.
authors.affiliation: Department of Laboratory Medicine, Molecular Biology Division, University of Vienna Medical School, Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Endler
authors.forename: W
authors.initials: W
authors.lastname: Lalouschek
authors.forename: M
authors.initials: M
authors.lastname: Exner
authors.forename: G
authors.initials: G
authors.lastname: Mitterbauer
authors.forename: D
authors.initials: D
authors.lastname: Häring
authors.forename: C
authors.initials: C
authors.lastname: Mannhalter
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors; D020521:Stroke / Q000235:genetics*
chemical_list: D017395:Plasminogen Activator Inhibitor 1