title: Biosynthesis, release, and uptake of carnosine in primary cultures.
abstract: Biosynthesis, release, and uptake of carnosine (beta-alanyl-L-histidine) in highly enriched primary cell cultures of skeletal muscle and CNS tissue have been investigated. The synthesis is restricted to muscle cells, oligodendrocytes, and ensheathing cells of olfactory bulb and increases during differentiation of these cells. Astrocytes, in contrast, do not synthesize carnosine but are equipped with a dipeptide transporter by which carnosine is taken up very efficiently.
authors.affiliation: Max-Planck-Institut für Experimentelle Endokrinologie, D-30625 Hannover, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Bakardjiev
authors.forename: K
authors.initials: K
authors.lastname: Bauer
mesh_terms: D000818:Animals; D002336:Carnosine / Q000096:biosynthesis* / Q000378:metabolism; D002478:Cells, Cultured
chemical_list: D002336:Carnosine