[Fertility after chemotherapy of gestational trophoblastic disease].
OBJECTIVE
To evaluate subsequent pregnancy experience in patients following chemotherapy for malignant form of gestational trophoblastic disease.


METHODS
Retrospective clinical study.


METHODS
Slovak Center of Trophoblastic Disease, Bratislava, Slovak Republic.


METHODS
There were evaluated subsequent pregnancy experiences in 38 patients after chemotherapy for malignant form of gestational trophoblastic disease registered in Slovak center of gestational trophoblastic disease. Histological and cytogenetical analysis of all placentas after deliveries and material from curettage specimens after miscarriages, abortions and ectopic pregnancies were performed.


RESULTS
11 women conceived following successful chemotherapy of gestational trophoblastic disease became pregnant a total 19 times. Out of them there were 9 full-term deliveries, 2 spontaneous abortion, 1 ended in ectopic pregnancy and 7 pregnancies were terminated in therapeutic abortion. Cytogenetical analysis was successful in 7 to 10 reproductive losses with normal karyotype in all analysed cases.


CONCLUSIONS
Patients after successful chemotherapy of gestational trophoblastic disease have a normal reproductive outcome.
Korbe'l
M
M
Centrum pre trofoblastovú chorobu Slovenskej republiky.
Danihel
L
L
Vojtassák
J
J
Sufliarsky
J
J
Redecha
M
M
Niznanská
Z
Z
Bohmer
D
D
Repiská
V
V
Ilavská
I
I
D000970:Antineoplastic Agents / Q000009:adverse effects; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000139:chemically induced; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D012189:Retrospective Studies; D014328:Trophoblastic Neoplasms / Q000188:drug therapy*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents