title: Bioactivity of sol-gel bioactive glass coated alumina implants.
abstract: Alumina on alumina total hip arthroplasty has been in use for more than 25 years with encouraging results. However, an improvement of the alumina/bone interface still is required. The objective of this study was to investigate the in vitro and in vivo osteoconductive properties of sol-gel bioactive glass coated alumina implants. Two sol-gel glass compositions (58S Bioglass(R) and 77S Bioglass(R)) were used as coatings on alumina substrates and implanted in a rabbit model. The 58S sol-gel coating was employed in two configurations, single (A58S1) and double layer (A58S2). SEM analysis after one week in simulated body fluid revealed small crystals assumed to represent the initial phase of hydroxyapatite formation, whereas no clear conclusion could be drawn from Fourier transform infrared spectroscopy data. The percentage of bone in direct contact was greater for coated implants when compared to bulk alumina implants (p <0.001). In the case of A58S1 implants, bone percentage significantly increased from 45.1% after 3 weeks up to 87. 8% after 24 weeks of implantation (p = 0.0004). The presence of osteoid tissue, related to an aluminum release from the alumina substrates, was greatly diminished when compared to melt-derived glass-coated alumina implants.
authors.affiliation: Laboratoire de Recherches Orthopédiques, Faculté de Médecine Lariboisière-St Louis, Université D. Diderot Paris VII, UPRES A CNRS 7052, 10 Avenue de Verdun, 75010 Paris, France. moussah@club-internet.fr
authors.forename: M
authors.initials: M
authors.lastname: Hamadouche
authors.forename: A
authors.initials: A
authors.lastname: Meunier
authors.forename: D C
authors.initials: DC
authors.lastname: Greenspan
authors.forename: C
authors.initials: C
authors.lastname: Blanchat
authors.forename: J P
authors.initials: JP
authors.lastname: Zhong
authors.forename: G P
authors.initials: GP
authors.lastname: La Torre
authors.forename: L
authors.initials: L
authors.lastname: Sedel
mesh_terms: D000537:Aluminum Oxide; D000818:Animals; D019644:Arthroplasty, Replacement, Hip; D001672:Biocompatible Materials; D005898:Glass; D006801:Humans; D007595:Joint Prosthesis; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D000537:Aluminum Oxide