title: [Community acquired pneumonia: from intravenous to oral cephalosporin sequential therapy].
abstract: BACKGROUND
  Many hospitalized patients with community acquired pneumoniae can be switched early in the course of therapy from intravenous to oral antibiotics, when there are subjective and objective indicators of improvement. This modality of treatment is called "switch therapy".
  
  
  OBJECTIVE
  To compare sequential therapy using an oral third generation cephalosporin, with conventional therapy using intravenous ceftriaxone in community acquired pneumonia.
  
  
  METHODS
  Forty patients admitted due to community acquired pneumonia, initially treated with ceftriaxone 1 g/day i.v. and that showed clinical improvement after three days of therapy, were studied. They were randomly assigned to continue intravenous therapy with ceftriaxone for a total of 10 days or switched to ceftibuten 400 mg od for seven days.
  
  
  RESULTS
  Twenty one patients continued i.v. treatment and 19 were switched to ceftibuten. There were no differences between both groups in terms of clinical cure, radiological improvement or normalisation of white blood cell count.
  
  
  CONCLUSIONS
  Patients with community acquired pneumonia that have a good initial response to intravenous antimicrobials, can be safely switched to oral therapy. This therapy will shorten hospital stay and thereby treatment costs.
authors.affiliation: Servicio de Medicina, Instituto Nacional del Tórax, Santiago, Chile.
authors.forename: P
authors.initials: P
authors.lastname: Fernández
authors.forename: L
authors.initials: L
authors.lastname: San Martín
mesh_terms: D000284:Administration, Oral; D000368:Aged; D002443:Ceftriaxone / Q000008:administration & dosage*; D002511:Cephalosporins / Q000008:administration & dosage*; D017714:Community-Acquired Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D011014:Pneumonia / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D002511:Cephalosporins; D002443:Ceftriaxone