Sulfur-containing palladacycles: efficient phosphine-free catalyst precursors for the Suzuki cross-coupling reaction at room temperature.
[reaction: see text] Cyclopalladated compounds derived from the ortho-metalation of benzylic tert-butyl thioethers are excellent catalyst precursors for the Suzuki cross-coupling reaction of aryl bromides and chlorides with phenylboronic acid under mild reaction conditions. A broad range of substrates and functional groups are tolerated in this protocol, and highly catalytic activity is attained.
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Laboratory of Molecular Catalysis, Instituto de Química, UFRGS, Av. Bento Gonçalves, 9500 Porto Alegre, RS 91501-970, Brazil.
Gruber
A S
AS
Ebeling
G
G
Dupont
J
J
Monteiro
A L
AL