title: Clinical research. Flawed cancer study leads to shake-up at University of Oklahoma.
abstract: Allegations of lax safety procedures and flawed management in a clinical cancer trial have cost four researchers and administrators their jobs at the University of Oklahoma. They have also led to a temporary shutdown of 75 clinical trials at the university's Health Science Center in Tulsa and a sweeping overhaul of the school's process for approving human experiments. University officials emphasize that none of the roughly 100 patients involved in the 3-year-old study of an experimental cancer vaccine was known to have been harmed, and that most trials will soon be restarted.
authors.forename: D
authors.initials: D
authors.lastname: Malakoff
mesh_terms: D019496:Cancer Vaccines / Q000627:therapeutic use*; D002985:Clinical Protocols / Q000592:standards; D002986:Clinical Trials as Topic / Q000592:standards*; D006805:Human Experimentation; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D009825:Oklahoma; D011367:Professional Staff Committees; D014481:United States; D014483:United States Dept. of Health and Human Services; D014495:Universities
chemical_list: D019496:Cancer Vaccines