Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae.
The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).
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Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Italy.
Iannelli
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MR
Stefani
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Pozzi
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D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D001426:Bacterial Proteins; D001692:Biological Transport; D002876:Chromosomes, Bacterial; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000502:physiology; D006801:Humans; D018942:Macrolides; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D017422:Sequence Analysis, DNA; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D014769:Virginiamycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D018942:Macrolides; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D014769:Virginiamycin