Transformation of hepatitis B virus-related membranous glomerulonephritis to crescentic form.
We report a case of hepatitis B virus-(HBV) related membranous glomerulonephritis which progressed to crescentic transformation after withdrawal of immunosuppressive treatment. Immunosuppressive therapy probably enhanced HBV replication, and its withdrawal led to a return of immune competence resulting in progression of the glomerulonephritis. Prior screening of all patients for hepatitis B surface antigen, before using immunosuppressive therapy may prevent this complication. The usage of immunosuppressive therapy as a first-line choice in HBV-related glomerulonephritis may result in harmful complications.
Taskapan
H
H
Nephrology Department of Erciyes University Medical School, Kayseri, Turkey.
Oymak
O
O
Dogukan
A
A
Ozbakir
O
O
Utas
C
C
D000328:Adult; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D005921:Glomerulonephritis / Q000473:pathology*; D015433:Glomerulonephritis, Membranous / Q000473:pathology / Q000821:virology*; D006509:Hepatitis B / Q000150:complications*; D006515:Hepatitis B virus / Q000254:growth & development*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D014779:Virus Replication
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone