A solid-phase synthesis for beta-turn mimetics of sialyl Lewis X.
A solid-phase synthesis of heterocyclic beta-turn mimetics of sialyl Lewis X, which is a natural carbohydrate ligand of selectins, was established. This synthetic method could be very useful for drug discovery of selectin antagonists using combinatorial chemistry techniques.
Kurokawa
K
K
Department of Chemistry, R&D Laboratories, Nippon Organon K.K., Osaka, Japan.
Kumihara
H
H
Kondo
H
H
D004797:Enzyme-Linked Immunosorbent Assay; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D008362:Mannosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018716:Molecular Mimicry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D019087:Selectins / Q000737:chemistry* / Q000378:metabolism*; D000080506:Sialyl Lewis X Antigen
D006573:Heterocyclic Compounds, 1-Ring; D008362:Mannosides; D009844:Oligosaccharides; D019087:Selectins; D000080506:Sialyl Lewis X Antigen