Evidence for oxidative stress in experimental prion disease.
Oxidative stress has been shown to be important in several neurodegenerative disorders. Previous in vitro studies have already demonstrated the ability of a prion protein fragment to induce oxidative stress in cultured cells. By immunohistochemistry for nitrotyrosine (NT) and heme oxygenase-1 as markers for oxidative stress, we found widespread neuronal labeling for NT in scrapie-infected mouse brains, in agreement with peroxynitrite mediated neuronal degeneration. Damage by free radicals is a likely cause for neurodegeneration in prion disease, and antioxidants are a potential therapy of these disorders.
Guentchev
M
M
Austrian Reference Center for Human Prion Diseases and Institute of Neurology, University of Vienna, Vienna, A-1097, Austria.
Voigtländer
T
T
Haberler
C
C
Groschup
M H
MH
Budka
H
H
D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D051547:Heme Oxygenase-1; D008565:Membrane Proteins; D051379:Mice; D018384:Oxidative Stress; D017096:Prion Diseases / Q000378:metabolism*; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D008565:Membrane Proteins; C002744:3-nitrotyrosine; D014443:Tyrosine; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C496542:Hmox1 protein, mouse