title: Refractory Bacillus cereus infection in a neonate.
abstract: Bacillus cereus is a Gram-positive aerobic or facultatively anaerobic spore-forming rod, which usually causes food poisoning. Its recognition as a pathogen in neonates has increased over the past two decades. The clinical course of a neonate (gestation 24 weeks) with B. cereus infection refractory to therapy is described. Death occurred after withdrawal of support following persistently positive blood and bone marrow cultures despite therapy with vancomycin, gentamicin, imipenum, clindamycin, ciprofloxacillin, immunoglobulin and granulocyte colony stimulating factor over a period of 49 days. No obvious focus of sepsis was identified. Contamination from the environment into the hospital and clinics occurs because of the ubiquitous presence of B. cereus. Combination therapy with vancomycin and gentamycin is appropriate for meningitis/severe systemic infections related to most bacillus species. The significance of repeated isolation of B. cereus in neonates with compromised host defences is emphasised.
authors.affiliation: Department of Neonatology, Kirwan Hospital for Women, Thuringowa, Queensland, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Tuladhar
authors.forename: S K
authors.initials: SK
authors.lastname: Patole
authors.forename: T H
authors.initials: TH
authors.lastname: Koh
authors.forename: R
authors.initials: R
authors.lastname: Norton
authors.forename: J S
authors.initials: JS
authors.lastname: Whitehall
mesh_terms: D000900:Anti-Bacterial Agents; D001409:Bacillus cereus / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D017809:Fatal Outcome; D006801:Humans; D007231:Infant, Newborn; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents