title: A review of the development of chicken lines to resolve genes determining resistance to diseases.
abstract: The resolution of genes that determine resistance to disease is described using chicken lines maintained at the Avian Disease and Oncology Laboratory (ADOL). This description includes a summary 1) of existing selected and inbred lines differing for resistance to viral-induced tumors, i.e., Marek's disease (MD) and lymphoid leukosis (LL), and of the use of inbred and line crosses to define relevant disease-resistant genes, e.g., TV, ALVE, B, R, LY4, TH1, BU1, and IGG1; 2) of the development of TVB*/ALVE congenic lines to establish the affects of endogenous virus (EV) expression on resistance to avian leukosis virus (ALV), and methods to detect ALVE expression; 3) of the development of B congenic lines to define the influence of the MHC on MD resistance and vaccinal immunity, for producing B antisera, and for evaluating DNA sequences of Class I and II genes; and 4) of the current development of 6C.7 recombinant congenic strains (RCS) to define the role of non-MHC genes influencing susceptibility to MD and LL tumors, immune competence, and epistatic effects of genes. The procedures of pedigree mating, to avoid or maintain inbreeding, and of blood-typing, to ensure genetic purity of the lines, are also described.
authors.affiliation: US Department of Agriculture, Agricultural Research Service, Avian Disease and Oncology Laboratory, East Lansing, Michigan 48823, USA. baconld@pilot.msu.edu
authors.forename: L D
authors.initials: LD
authors.lastname: Bacon
authors.forename: H D
authors.initials: HD
authors.lastname: Hunt
authors.forename: H H
authors.initials: HH
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001947:Breeding; D002645:Chickens / Q000235:genetics*; D004198:Disease Susceptibility / Q000662:veterinary; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate / Q000235:genetics*; D007178:Inbreeding; D014412:Tumor Virus Infections / Q000235:genetics / Q000662:veterinary; D014777:Virus Diseases / Q000235:genetics / Q000662:veterinary