The genomic structure of c14orf1 is conserved across eukarya.
We have recently cloned the gene C14orf1, which is strongly expressed in normal testis and in several cancer cell lines and tumors. This gene maps to 14q24.3 and is interrupted by four introns. Two of them are also represented in the open reading frame of Schizosaccharomyces pombe in the same phase. In Arabidopsis taliana only the first of the two introns was found, in the same phase as the corresponding ones in S. pombe and human. Disruption of the ortholog in Saccharomyces cerevisiae (Yer044c) led to a severe growth defect, and C14orf1 failed to complement mutant yeast when put under the control of the natural Yer044c promoter. Further studies are needed to understand the causes underlying the high degree of conservation of the C14orf1 genomic structure.
Ottolenghi
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C
Unité d'Immunogénétique Humaine, Institut Pasteur, 25 rue du Dr. Roux, 75724, Paris, France.
Daizadeh
I
I
Ju
A
A
Kossida
S
S
Renault
G
G
Jacquet
M
M
Fellous
A
A
Gilbert
W
W
Veitia
R
R
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005057:Eukaryotic Cells / Q000378:metabolism*; D005091:Exons; D005796:Genes / Q000235:genetics*; D005816:Genetic Complementation Test; D006801:Humans; D007438:Introns; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D009363:Neoplasm Proteins; D010802:Phylogeny; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
C121701:ERG28 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D004247:DNA