[Apoptosis in allergic disease].
Apoptosis (cell programmed death) it is a mechanism that implicate a physiological suicide, to keep the cellular homeostasis in big amount of tissues. Fas (APO-1; CD95) system is one of the most important cellular responsible via to induce apoptosis on different tissues. Eosinophillia on peripheral blood and tissues are the main characteristics on allergic like asthma. Eosinophil apoptosis is upper regulated in those diseases by IL-5 y GM-CSF. Corticoids, teophyllin and some macrolids have been used like apoptosis inductors on eosinophills, these could be a novel mechanism to promote a better solution on inflammatory allergic diseases.
Rojas Ramos
E
E
Servicio de Alergia e Inmunología, Hospital Regional 1 degree de Octubre, ISSSTE, México. rojasenrique@infosel.com
Martínez Jiménez
N E
NE
Martínez Aguilar
N E
NE
Garfias Becerra
J
J
D017209:Apoptosis / Q000187:drug effects; D001249:Asthma / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D053938:DNA Fragmentation; D004802:Eosinophilia / Q000209:etiology / Q000276:immunology / Q000473:pathology; D004804:Eosinophils / Q000187:drug effects / Q000473:pathology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D007249:Inflammation; D015848:Interleukin-5 / Q000502:physiology; D019014:fas Receptor / Q000502:physiology
D015848:Interleukin-5; D019014:fas Receptor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor