title: Handedness and mortality: a follow-up study of Danish twins born between 1900 and 1910.
abstract: The declining prevalence of left-handed individuals with increasing age has led to two main avenues of hypotheses; the association is due either (1) to a birth cohort effect and/or an age effect caused by a switch to right-handedness with advancing age or (2) to mortality selection that reduces survival in left-handed individuals, or both. It is uncertain whether a cohort or age effect can explain the decline in age-related prevalence, and conflicting evidence exists in favor of the mortality hypothesis. We compared mortality in a subgroup of 118 opposite-handed twin pairs by counting in how many instances the right-handed twin died first. There was no evidence of differential survival between right-handed and non-right-handed individuals in the entire 1900-1910 cohort. With respect to the number of right-handed twins who died first, there was no material disadvantage among those who were not right-handed. In 60% (95% confidence interval = 49.0-71.5%) of dizygotic pairs, the right-handed twins died first. In 50% of monozygotic pairs, right-handed twins died first. The prevalence of not being right-handed was higher among males (9.2%) than females (6.5%); there was a similar frequency of non-right-handedness in monozygotic (8.0%) and dizygotic (7.8%) twins. We did not find evidence of excess mortality among non-right-handed adult twins in this follow-up study.
authors.affiliation: The Danish Epidemiology Science Centre at the Department of Epidemiology and Social Medicine, Aarhus University.
authors.forename: O
authors.initials: O
authors.lastname: Basso
authors.forename: J
authors.initials: J
authors.lastname: Olsen
authors.forename: N V
authors.initials: NV
authors.lastname: Holm
authors.forename: A
authors.initials: A
authors.lastname: Skytthe
authors.forename: J W
authors.initials: JW
authors.lastname: Vaupel
authors.forename: K
authors.initials: K
authors.lastname: Christensen
mesh_terms: D002423:Cause of Death; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D007839:Functional Laterality / Q000235:genetics*; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D009026:Mortality; D015995:Prevalence; D012042:Registries; D016019:Survival Analysis; D014427:Twins / Q000235:genetics*