title: Lymphoma in the ear.
abstract: BACKGROUND
  Malignant tumors of the ear are rare. The most common malignant tumors are squamous cell carcinomas and adenocarcinomas. Lymphoma in the ear is rare.
  
  
  METHODS
  We report 2 cases of a primary presentation of a lymphoma of the ear. The literature since 1947 is reviewed.
  
  
  RESULTS
  An 83-year-old woman with an anaplastic large cell lymphoma of the skin of the external auditory meatus and a 75-year-old man with a B-cell non-Hodgkin's lymphoma of the mastoid process are presented. The literature review shows that only 16 cases of lymphomas of the ear have been reported so far.
  
  
  CONCLUSIONS
  In a case of therapy-resistant otitis and/or peripheral facial paralysis malignancy should be excluded by computer tomography of the mastoid. For histopathological diagnosis unfixed specimens are preferable. Uniform treatment of lymphomas of the ear has not been established.
authors.affiliation: Department of Otolaryngology and Head and Neck Surgery, Academical Medical Center, Amsterdam, The Netherlands. P.Merkus@amc.uva.nl
authors.forename: P
authors.initials: P
authors.lastname: Merkus
authors.forename: M P
authors.initials: MP
authors.lastname: Copper
authors.forename: M H
authors.initials: MH
authors.lastname: Van Oers
authors.forename: P F
authors.initials: PF
authors.lastname: Schouwenburg
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000627:therapeutic use; D004428:Ear Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D004432:Ear, Middle / Q000473:pathology; D005158:Facial Paralysis / Q000209:etiology; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008297:Male; D010033:Otitis Media / Q000175:diagnosis; D011241:Prednisone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone