NA antigen frequencies in the Tunisian population.
The biallelic NA antigen system is of special interest as the NA antigens are frequent targets of neutrophil antibodies, causing alloimmune neonatal neutropenia, blood transfusion reactions, and chronic benign autoimmune neutropenia in infancy. Neutrophils isolated from the peripheral blood of 119 unrelated individuals at the National Blood Center were phenotyped for NA1 and NA2 using a granulocyte immunofluorescence assay. A subsequent analysis of the phenotyping study showed that the NA1 and NA2 antigen frequencies were 0.529 and 0.865 respectively, and that the estimated NA1 and NA2 gene frequencies were 0.313 and 0.632 respectively. In conclusion, it was determined that the Tunisian population is of Caucasian origin. However, to validate this finding, further investigations are necessary.
Abid
S
S
National Blood Center, Tunis, Tunis.
Nsiri
B
B
Sall
A
A
Joudi
K
K
Jenhani
F
F
Boukef
K
K
D001208:Asia / Q000208:ethnology; D044383:Black People / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D005060:Europe / Q000208:ethnology; D005602:France / Q000208:ethnology; D005787:Gene Frequency; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D007194:India / Q000208:ethnology; D007198:Indians, North American / Q000235:genetics; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics; D010641:Phenotype; D013030:Spain / Q000208:ethnology; D014416:Tunisia / Q000453:epidemiology; D014481:United States / Q000208:ethnology; D044465:White People / Q000235:genetics; D001741:Black or African American
D007519:Isoantigens; C067704:neutrophil-specific antigen NA1, human; C072753:neutrophil-specific antigen NA2