Enhancing the enantioselectivity of lipase in transesterification by substrate matching: an enzyme memory based approach.
The substrate matching strategy is described as a new approach for effectively enhancing the lipase enantioselectivity in organic solvent. In the lipase-catalyzed transesterifications of 3a-c, higher enantioselectivities have been achieved using 1a-c, respectively, as the structurally matched acyl donors.
Lee
D
D
Department of Chemistry, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea.
Choi
Y K
YK
Kim
M J
MJ
D016956:Burkholderia cepacia / Q000201:enzymology; D002175:Candida / Q000201:enzymology; D004952:Esters / Q000737:chemistry*; D008049:Lipase / Q000378:metabolism; D012997:Solvents; D013237:Stereoisomerism; D013379:Substrate Specificity
D004952:Esters; D012997:Solvents; D008049:Lipase