title: Time course of oxidative stress after major burns.
abstract: OBJECTIVE
  To evaluate oxidative stress resulting from major burns in humans.
  
  
  METHODS
  Prospective clinical study with control group.
  
  
  METHODS
  Mechanically ventilated adult patients admitted with more than 30% total burn surface area.
  
  
  METHODS
  20 patients with a mean body surface burned area of 54%.
  
  
  RESULTS
  The oxidative stress evaluation was based on measurements of trace elements, vitamins, antioxidant enzymatic activity and end-products of lipid peroxidation. During the first 5 days after injury burn patients exhibit a decrease in selenium and antioxidant vitamins (C, beta-carotene, lycopene) and an increase in lipid peroxidation products (TBARS).
  
  
  CONCLUSIONS
  Our results suggest that major burn is associated with oxidative stress during the 5 days after the initial injury, as demonstrated by a simultaneous decrease in antioxidant vitamins and a large increase in TBARS.
authors.affiliation: Centre des Brulés, Hôpital E. Herriot, Lyon, France. marc.bertin-maghit@chu-lyon.fr
authors.forename: M
authors.initials: M
authors.lastname: Bertin-Maghit
authors.forename: J
authors.initials: J
authors.lastname: Goudable
authors.forename: E
authors.initials: E
authors.lastname: Dalmas
authors.forename: J P
authors.initials: JP
authors.lastname: Steghens
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
authors.forename: P Y
authors.initials: PY
authors.lastname: Gueugniaud
authors.forename: P
authors.initials: P
authors.lastname: Petit
authors.forename: B
authors.initials: B
authors.lastname: Delafosse
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000503:physiopathology*; D016022:Case-Control Studies; D006801:Humans; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D011446:Prospective Studies; D013997:Time Factors; D014131:Trace Elements / Q000097:blood; D014815:Vitamins / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014131:Trace Elements; D014815:Vitamins