Effect of melatonin on lenticular calcium and magnesium in rats exposed to ultraviolet radiation.
Six-week-old rats received 8 kJ/m(2) ultraviolet B (UVB) for 15 min. For the intervention in cataract development, intraperitoneal injection of melatonin (4 mg/kg daily for 1 week) following UVB exposure was performed. Lenticular calcium and magnesium levels were determined in UVB + melatonin, UVB and control groups. One week after exposure, significantly more cataractous changes were observed in the UVB group than the UVB + melatonin group. The mean lens calcium and magnesium levels for the UVB group were significantly higher than those for the control and the UVB + melatonin groups. There were no significant differences between the control and the UVB + melatonin groups for the mean lens calcium and magnesium levels.
Bardak
Y
Y
Department of Ophthalmology, Süleyman Demirel University, Medical School, Isparta, Turkey. ybardak@hotmail.com
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers; D002118:Calcium / Q000378:metabolism*; D002386:Cataract / Q000209:etiology / Q000378:metabolism*; D005260:Female; D007274:Injections, Intraperitoneal; D007908:Lens, Crystalline / Q000378:metabolism / Q000528:radiation effects*; D008274:Magnesium / Q000378:metabolism*; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014466:Ultraviolet Rays / Q000009:adverse effects*
D000975:Antioxidants; D015415:Biomarkers; D008274:Magnesium; D008550:Melatonin; D002118:Calcium