Peripheral neuropathy in B6C3F1 mice and SD rats induced by chronic intermittent insulin hypoglycemia.
The effects of sustained insulin-induced hypoglycemia on peripheral nerves were examined in 9-10-week old female B6C3F1 mice and 9-10-week old female SD rats. Insulin was administered via osmotic minipumps at a dose of 81 IU/kg/day for 2 consecutive weeks. Mice and rats treated with this high insulin dose showed marked hypoglycemia, resulting in half the normal blood glucose level, hypothermia, impaired motor nerve conduction velocity, and an increased incidence of peripheral nerve lesions, consisting of nerve fiber degeneration characterized by irregular myelin sheaths and axonal atrophy.
Tabata
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Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan. tabata@yamanouchi.co.jp
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D001917:Brachial Plexus / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D016503:Drug Delivery Systems; D005260:Female; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009431:Neural Conduction / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects / Q000503:physiopathology*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects / Q000503:physiopathology; D013045:Species Specificity; D013979:Tibial Nerve / Q000187:drug effects / Q000503:physiopathology
D001786:Blood Glucose; D007328:Insulin