[Spectroscopic imaging (1H-2D-CSI) of the prostate: sequence optimization and correlation with histopathological results].
OBJECTIVE
Methodological optimization of a 1H MR spectroscopic imaging sequence (1H-2D-CSI) and evaluation of its potential to diagnose prostate cancer as validated by histopathological maps.


METHODS
The prostates of 18 patients were evaluated by 1H-MR-CSI (voxel dimension: 1 cm3) at 1.5 Tesla. This sequence was additionally combined with a frequency selective fat suppression.


RESULTS
It was possible to distinguish prostate carcinoma from prostate hyperplasia spectroscopically by the ratio of citrate/(choline + creatine). Differentiation of high-grade prostatic intraepithelial neoplasia (PIN, high-grade) from prostate carcinoma was not unambiguously possible. Prediction of tumor differentiation was not possible by the ratio of citrate/(choline + creatine) by our maximum spatial resolution of 1 cm3.


CONCLUSIONS
1H-2D-CSI is suitable for tumor detection. Tumor differentiation was not possible with the spatial resolution used.
Stanka
M
M
Institut für Klinische Radiologie, Westfälische Wilhelms-Universität Münster. stanka@uni-muenster.de
Eltze
E
E
Semjonow
A
A
Sievert
K D
KD
Maier
A
A
Pfleiderer
B
B
D000368:Aged; D002794:Choline / Q000032:analysis; D002951:Citrates / Q000032:analysis; D003401:Creatine / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011467:Prostate / Q000033:anatomy & histology / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis; D011470:Prostatic Hyperplasia / Q000175:diagnosis* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D015203:Reproducibility of Results
D002951:Citrates; D017430:Prostate-Specific Antigen; D003401:Creatine; D002794:Choline