title: SCID mice as a tool for evaluation of heteroxenous life cycle pattern of Caryospora (Apicomplexa, Eimeriidae) species.
abstract: Adult severe combined immunodeficient (SCID) mice were inoculated with oocysts of 13 different Caryospora (Protozoa, Apicomplexa) species isolated from the faeces of 10 reptilian and three raptorial bird hosts in attempt to test heteroxenous life cycle pattern. Only three reptilian isolates originated from viperid snakes, namely from Calloselasma rhodostoma, Atheris nitschei and Vipera ursinii induced lethal dermal caryosporosis in SCID mice. Neither clinical signs nor developmental stages were observed in mice infected with further nine caryosporan isolates originated from other reptilian and raptorial bird hosts. Results of this study confirmed that SCID mice represent a useful tool for evaluation of heteroxenous life cycle pattern of caryosporan coccidia and that only the Caryospora species from viperid and crotalid snakes produce dermal caryosporosis in mice
authors.affiliation: Department of Parasitology, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, 612 42, Brno, Czech Republic. koudelab@vfu.cz
authors.forename: B
authors.initials: B
authors.lastname: Koudela
authors.forename: D
authors.initials: D
authors.lastname: Modrý
authors.forename: J
authors.initials: J
authors.lastname: Volf
authors.forename: J R
authors.initials: JR
authors.lastname: Slapeta
mesh_terms: D000818:Animals; D003048:Coccidiosis / Q000473:pathology / Q000662:veterinary; D021743:Eimeriidae / Q000254:growth & development*; D008018:Life Cycle Stages; D051379:Mice; D016513:Mice, SCID / Q000469:parasitology*; D012376:Rodent Diseases / Q000469:parasitology / Q000473:pathology