title: Oxidative processes in Alzheimer's disease: the role of abeta-metal interactions.
abstract: Alzheimer's disease is characterized by signs of a major oxidative stress in the neocortex and the concomitant deposition of Amyloid beta (Abeta). Abeta is a metalloprotein that binds copper, and is electrochemically active. Abeta converts molecular oxygen into hydrogen peroxide by reducing copper or iron, and this may lead to Fenton chemistry. Hydrogen peroxide is a freely permeable prooxidant that may be responsible for many of the oxidative adducts that form in the Alzheimer-affected brain. The electrochemical activity of various Abeta species correlates with the peptides' neurotoxicity in cell culture, and participation in the neuropathology of Alzheimer's disease. These reactions present a novel target for Alzheimer therapeutics.
authors.affiliation: Department of Pathology, The University of Melbourne, and Neuropathology Laboratory, The Mental Health Research Institute of Victoria, Vic. 3052, Parkville, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Lynch
authors.forename: R A
authors.initials: RA
authors.lastname: Cherny
authors.forename: A I
authors.initials: AI
authors.lastname: Bush
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000502:physiology; D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D008670:Metals / Q000378:metabolism; D009498:Neurotoxins / Q000378:metabolism; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D008670:Metals; D009498:Neurotoxins; D017382:Reactive Oxygen Species