Visual function, fatty acids and dyslexia.
There is mounting evidence that developmental dyslexia is a neurodevelopmental disorder which involves abnormalities of fatty acid metabolism, particularly with respect to certain long-chain highly unsaturated fatty acids (HUFAs). Psychophysical evidence also strongly suggests that dyslexics may have visual deficits as well as phonological problems. Specifically, these visual deficits appear to be related to the magnocellular pathway, which is specialized for processing fast, rapidly-changing information about the visual scene. It remains unclear how these two aspects of dyslexia - fatty acid processing and visual magnocellular function - could be related. We propose some hypotheses - necessarily speculative, given the paucity of biochemical research in this field to date - which address this question.
Taylor
K E
KE
University Laboratory of Physiology, Oxford, UK. kathleen.taylor@physiol.ox.au.uk
Richardson
A J
AJ
D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D004410:Dyslexia / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006801:Humans; D008051:Lipid Bilayers; D009474:Neurons / Q000276:immunology / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D014786:Vision Disorders / Q000209:etiology*; D014795:Visual Pathways / Q000503:physiopathology*
D005231:Fatty Acids, Unsaturated; D008051:Lipid Bilayers; D010743:Phospholipids