title: Evidence for a protein related immunologically to the jaagsiekte sheep retrovirus in some human lung tumours.
abstract: Human bronchioloalveolar carcinoma (BAC) is a lung cancer, morphologically similar to an endemic contagious lung neoplasm of sheep called sheep pulmonary adenomatosis (SPA) or jaagsiekte. SPA is caused by an exogenous type B/D retrovirus (jaagsiekte sheep retrovirus (JSRV)), which prompted the present study to obtain evidence of a retrovirus in BAC. A panel of 249 human lung tumours, 21 nontumour lung lesions, four normal lung tissues, 23 adenocarcinomas from other organs and a cell line expressing a human endogenous retrovirus protein was examined immunohistochemically using a rabbit antiserum directed against the JSRV capsid protein. Specific staining was detected only in the cytoplasm of recognizably neoplastic cells in the pulmonary alveoli of 39 of 129 (30%) BACs, 17 of 65 (26%) lung adenocarcinomas and two of seven large cell carcinomas. The remaining samples were negative. These results support the hypothesis that some human pulmonary tumours may be associated with a jaagsiekte sheep retrovirus-related retrovirus, warranting further studies.
authors.affiliation: Departamento de Patologia Animal, Universidad de Zaragoza, Saragossa, Spain.
authors.forename: M
authors.initials: M
authors.lastname: De las Heras
authors.forename: S H
authors.initials: SH
authors.lastname: Barsky
authors.forename: P
authors.initials: P
authors.lastname: Hasleton
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.forename: E
authors.initials: E
authors.lastname: Larson
authors.forename: J
authors.initials: J
authors.lastname: Egan
authors.forename: A
authors.initials: A
authors.lastname: Ortin
authors.forename: J A
authors.initials: JA
authors.lastname: Gimenez-Mas
authors.forename: M
authors.initials: M
authors.lastname: Palmarini
authors.forename: J M
authors.initials: JM
authors.lastname: Sharp
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000378:metabolism*; D018287:Carcinoma, Large Cell / Q000378:metabolism*; D002460:Cell Line; D006801:Humans; D022141:Jaagsiekte sheep retrovirus / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D008171:Lung Diseases / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism*; D011650:Pulmonary Alveoli / Q000378:metabolism; D012016:Reference Values; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D014764:Viral Proteins