title: Effectiveness and complications of vascular access closure devices after interventional procedures.
abstract: BACKGROUND
  Vascular closure devices are designed to obtain a fast hemostasis of the vascular access site after diagnostic and interventional procedures. This result should be obtained with a low incidence of complications.
  
  
  METHODS
  A retrospective, non-randomized study was performed to evaluate the success rate and vascular complications associated with the use of two different vascular sealing devices [Angio-Seal (Daig Corporation, Minnetonka, Minnesota) and Prostar (Perclose, Inc., Redwood City, California)] after interventional procedures.
  
  
  RESULTS
  Eight-hundred and twenty-seven devices were used (245 Angio-Seal and 582 Prostar). Angio-Seal success rate was 92% with a 2.5% rate of vascular complications; Prostar success rate was 89% with a 3.4% rate of vascular complications. Multivariate logistic regression analysis identified advanced age (p < 0.05) and lower weight (p < 0.05) as independent predictors of vascular complications associated with Angio-Seal use, while diabetes (p < 0.05) was found to be a predictor of vascular complications in the Prostar group. Abciximab use and larger sheath size were not associated with an increased probability of vascular complications.
  
  
  CONCLUSIONS
  Angio-Seal and Prostar obtain a fast vascular access hemostasis after interventional procedures, with a low incidence of major vascular complications.
authors.affiliation: Centro Cuore Columbus, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Sesana
authors.forename: M
authors.initials: M
authors.lastname: Vaghetti
authors.forename: R
authors.initials: R
authors.lastname: Albiero
authors.forename: N
authors.initials: N
authors.lastname: Corvaja
authors.forename: G
authors.initials: G
authors.lastname: Martini
authors.forename: G
authors.initials: G
authors.lastname: Sivieri
authors.forename: A
authors.initials: A
authors.lastname: Colombo
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D017225:Atherectomy, Coronary / Q000009:adverse effects; D002408:Catheters, Indwelling / Q000009:adverse effects*; D004867:Equipment Design; D005260:Female; D005263:Femoral Artery; D006488:Hemostasis, Surgical / Q000295:instrumentation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000601:surgery*; D011677:Punctures / Q000009:adverse effects*; D012189:Retrospective Studies