title: [Prevalence of congenital malformations at birth and associated factors in Easter Island, Chile (1988-1998)].
abstract: BACKGROUND
  Consanguinity plays an important role in the genetic etiology of congenital malformations. In Easter Island the degree of consanguinity could be higher than in continental Chile. Therefore the study of the prevalence of congenital malformations in this island seems worthwhile.
  
  
  OBJECTIVE
  To study the prevalence of congenital malformations at birth in Easter Island.
  
  
  METHODS
  A review of personal and family features of all children born alive between 1988 and 1998 in the Rapa Nui Hospital of Easter Island.
  
  
  RESULTS
  During the study period, 772 newborns were reviewed and 22 were found to have congenital malformations. Among the latter, birth weight fluctuated between 3001 and 4000 g and the male/female ratio was 0.54. No differences in maternal age between children with and without malformations was observed. Heart and circulatory malformations, hemangiomas and Down syndrome were the predominant malformations.
  
  
  CONCLUSIONS
  The prevalence of congenital malformations at birth in Easter Island is similar to that of continental Chile. No neural tube defects were detected in this sample.
authors.affiliation: Departamento de Obstetricia y Ginecología, Universidad de Chile. alfagu@intermedia.cl
authors.forename: A
authors.initials: A
authors.lastname: Aguila
authors.forename: J
authors.initials: J
authors.lastname: Nazer
authors.forename: L
authors.initials: L
authors.lastname: Cifuentes
authors.forename: P
authors.initials: P
authors.lastname: Mella
authors.forename: P
authors.initials: P
authors.lastname: de la Barra
authors.forename: D
authors.initials: D
authors.lastname: Gutiérrez
mesh_terms: D000293:Adolescent; D000328:Adult; D002677:Chile / Q000453:epidemiology; D000013:Congenital Abnormalities / Q000453:epidemiology*; D003241:Consanguinity; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors