The weaver gene has no effect on the generation patterns of mesencephalic dopaminergic neurons.
To determine if the weaver gene has action on late-generated neurons in midbrain areas on postnatal day (P) 8 [(3)H] thymidine autoradiography and tyrosine hydroxylase immunohistochemistry were combined in the same tissue section in homozygous weaver mice and normal controls. The experimental animals were the offspring of pregnant dams injected with [3H] thymidine on embryonic days (E)11-12, E12-13, E13-14 and E14-15. Both the span of neurogenesis and the neurogenetic timetables of dopaminergic neurons were similar between wild-type and homozygous weavers in all midbrain areas analyzed. No loss of late-generated dopaminergic neurons was observed. The cytoarchitecture of the midbrain dopaminergic cell groups were also the same in both experimental groups indicating that cell migration, settling, and cytodifferentiation proceeds normally in spite of the presence of the weaver gene.
Martí
J
J
Department of Biology, Indiana-Purdue University, Indianapolis, IN 46202, USA. ibhc0@cc.uab.es
Wills
K V
KV
Ghetti
B
B
Bayer
S A
SA
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D002452:Cell Count; D004298:Dopamine / Q000378:metabolism*; D008636:Mesencephalon / Q000254:growth & development / Q000378:metabolism* / Q000473:pathology*; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology*; D012012:Red Nucleus / Q000378:metabolism / Q000473:pathology; D013378:Substantia Nigra / Q000378:metabolism / Q000473:pathology; D013681:Tegmentum Mesencephali / Q000378:metabolism / Q000473:pathology
D004298:Dopamine