Fibroblast growth factor signaling is required for the proliferation and patterning of progenitor cells in the developing anterior pituitary.
The proliferation and patterning of progenitor cells in the anterior pituitary require signals derived from the neuroepithelium of the juxtaposed infundibulum. The infundibulum expresses Fibroblast growth factor (Fgf) 8 and Fgf 18, and FGFs can mimic some of the activities of the infundibulum. The requirement for FGF signaling during growth and patterning of the anterior pituitary has not, however, been established. By blocking FGF receptor signaling in explants of the anterior pituitary cultured in vitro we provide evidence that FGF signaling derived from the infundibulum is required for the proliferation and patterning of progenitor cells in the anterior pituitary.
Norlin
S
S
Department of Microbiology, Umeå University, S-901 87, Umeå, Sweden.
Nordström
U
U
Edlund
T
T
D000818:Animals; D019521:Body Patterning; D002454:Cell Differentiation; D002455:Cell Division; D046508:Culture Techniques; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D051379:Mice; D008808:Mice, Inbred CBA; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D010904:Pituitary Gland, Posterior / Q000378:metabolism; D010908:Pituitary Hormones, Anterior / Q000096:biosynthesis; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors; D010908:Pituitary Hormones, Anterior; D050817:Transcription Factor Pit-1; D014157:Transcription Factors; C496457:Fgf8 protein, mouse; C494185:Pou1f1 protein, mouse; C113569:fibroblast growth factor 18