Synthesis of purine derivatives of potential immunomodulatory activity.
Moving from the interest as immunomodulatory agent of ST789 was studied the synthesis of series of N9alkylated hypoxanthine and adenine. The synthesis and the chemical physical properties of these derivatives are here described.
Pini
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E
Istituto di Chimica Organica-Facoltà di Farmacia-Università degli Studi di Milano.
Rossi
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E
Cornaglia Ferraris
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P
Stradi
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R
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D011687:Purines