title: [Immunohistochemistry techniques in prion diseases].
abstract: The prion diseases are characterized by showing a broad spectrum of phenotypes with different clinical and neuropathological presentations. Detection of the prion protein is the marker used as a tool for making the definite diagnosis in these neurodegenerative diseases. Its presence may be detected by immunohistochemical and biochemical techniques. On immunohistochemical studies the prion protein shows three types of staining: as plaques of PrP-amyloid, perivascular and diffuse-synaptic.
authors.affiliation: Banco de Tejidos para Investigación Neurológica, Facultad de Medicina, Universidad Complutense de Madrid, España. igonzalo@lettera.net
authors.forename: I
authors.initials: I
authors.lastname: Gonzalo-Pascual
authors.forename: N
authors.initials: N
authors.lastname: Cuadrado-Corrales
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D017096:Prion Diseases / Q000145:classification / Q000378:metabolism*; D011328:Prions / Q000378:metabolism*
chemical_list: D011328:Prions