A short catalytic enantioselective synthesis of the proinflammatory eicosanoid 12(R)-hydroxy- 5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid (12(R)-HETE).
A new and effective pathway is described for the synthesis of 12(R)-HETE and the 12(S)-enantiomer from the common intermediates 4 and 8.
Han
X
X
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Corey
E J
EJ
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D007202:Indicators and Reagents; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid