Modulation of host immune responses by clinically relevant human DNA and RNA viruses.
Numerous mechanisms allow viruses to evade host immune surveillance, and new evasion strategies continue to be identified. In addition to interference with antigen processing and presentation, direct viral modulation of host immune responses can also be achieved by altering the host cytokine milieu and the development of immunoregulatory cells. A better understanding of these viral evasion strategies will help to define critical host defense mechanisms and will lead to novel immune-based therapeutic strategies in the future.
Brander
C
C
Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA.
Walker
B D
BD
D004266:DNA Virus Infections / Q000276:immunology* / Q000821:virology; D004267:DNA Viruses / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D012327:RNA Virus Infections / Q000276:immunology* / Q000821:virology; D012328:RNA Viruses / Q000276:immunology / Q000472:pathogenicity*