title: On the genealogy of a sample of neutral rare alleles.
abstract: This paper concerns the genealogical structure of a sample of chromosomes sharing a neutral rare allele. We suppose that the mutation giving rise to the allele has only happened once in the history of the entire population, and that the allele is of known frequency q in the population. Within a coalescent framework C. Wiuf and P. Donnelly (1999, Theor. Popul. Biol. 56, 183-201) derived an exact analysis of the conditional genealogy but it is inconvenient for applications. Here, we develop an approximation to the exact distribution of the conditional genealogy, including an approximation to the distribution of the time at which the mutation arose. The approximations are accurate for frequencies q<5-10%. In addition, a simple and fast simulation scheme is constructed. We consider a demography parameterized by a d-dimensional vector alpha=(alpha(1), em leader, alpha(d)). It is shown that the conditional genealogy and the age of the mutation have distributions that depend on a=qalpha and q only, and that the effect of q is a linear scaling of times in the genealogy; if q is doubled, the lengths of all branches in the genealogy are doubled. The theory is exemplified in two different demographies of some interest in the study of human evolution: (1) a population of constant size and (2) a population of exponentially decreasing size (going backward in time).
authors.affiliation: Department of Statistics, University of Oxford, 1 South Parks Road, Oxford, OXI 3TG, England.
authors.forename: C
authors.initials: C
authors.lastname: Wiuf
mesh_terms: D000465:Algorithms; D000483:Alleles; D005075:Biological Evolution; D005787:Gene Frequency / Q000235:genetics*; D006801:Humans; D008390:Markov Chains; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*; D010375:Pedigree; D011156:Population Density; D015203:Reproducibility of Results; D013997:Time Factors