Differentiation-inducing effect of magnolialide, a 1 beta-hydroxyeudesmanolide isolated from Cichorium intybus, on human leukemia cells.
Cichorium intybus contains two 1beta-hydroxyeudesmanolides, magnolialide and artesin, together with several constituents. Magnolialide inhibits the growth of several tumor cell lines and appears to induce differentiation of human leukemia HL-60 and U-937 cells to monocyte/macrophage-like cells. Another 1beta-hydroxyeudesmanolide, artesin, and other constituents were inactive. The content of magnolialide was shown to be highest in the leaves of Inje cultivar among the cultivars investigated in this study.
Lee
K T
KT
College of Pharmacy, Kyung-Hee University, Seoul, Korea.
Kim
J I
JI
Park
H J
HJ
Yoo
K O
KO
Han
Y N
YN
Miyamoto
K
K
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D018651:Cichorium intybus / Q000737:chemistry*; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D007938:Leukemia / Q000473:pathology*; D051379:Mice; D012717:Sesquiterpenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D007783:Lactones; D012717:Sesquiterpenes; C417229:magnolialide