title: Absence of evidence for a familial breast cancer susceptibility gene at chromosome 8p12-p22.
abstract: Several recent studies indicate that the majority of families with five or fewer cases of breast cancer and no cases of ovarian cancer are not due to BRCA1 or BRCA2. It has been proposed that a further breast cancer susceptibility gene that may account for some of these families is located on chromosome 8p12-p22. We have identified 31 site-specific breast cancer families that have a greater than 80% posterior probability of being due to genes other than BRCA1 or BRCA2. These families have been examined for linkage to 8p12-p22 using markers flanking the putative location of the gene. The overall multi-point LOD score is strongly negative across the whole 44 cM. The individual multi-point LOD score is negative in 23 families and only exceeds 0.5 in a single family (with a multi-point LOD score of 1.22). The maximum heterogeneity LOD score was 0.03 at marker D8S136 with estimated proportion linked (alpha) of 3% (95% CI 0 - 30%). These data do not lend support to the hypothesis that chromosome 8p12-p22 harbours a familial breast cancer susceptibility gene. Oncogene (2000) 19, 4170 - 4173
authors.affiliation: Section of Cancer Genetics, ICR, Sutton, SM2 5NG, UK.
authors.forename: N
authors.initials: N
authors.lastname: Rahman
authors.forename: M D
authors.initials: MD
authors.lastname: Teare
authors.forename: S
authors.initials: S
authors.lastname: Seal
authors.forename: H
authors.initials: H
authors.lastname: Renard
authors.forename: J
authors.initials: J
authors.lastname: Mangion
authors.forename: C
authors.initials: C
authors.lastname: Cour
authors.forename: D
authors.initials: D
authors.lastname: Thompson
authors.forename: Y
authors.initials: Y
authors.lastname: Shugart
authors.forename: D
authors.initials: D
authors.lastname: Eccles
authors.forename: P
authors.initials: P
authors.lastname: Devilee
authors.forename: H
authors.initials: H
authors.lastname: Meijers
authors.forename: K L
authors.initials: KL
authors.lastname: Nathanson
authors.forename: S L
authors.initials: SL
authors.lastname: Neuhausen
authors.forename: B
authors.initials: B
authors.lastname: Weber
authors.forename: J
authors.initials: J
authors.lastname: Chang-Claude
authors.forename: D F
authors.initials: DF
authors.lastname: Easton
authors.forename: D
authors.initials: D
authors.lastname: Goldgar
authors.forename: M R
authors.initials: MR
authors.lastname: Stratton
mesh_terms: D024682:BRCA2 Protein; D001943:Breast Neoplasms / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8; D004252:DNA Mutational Analysis; D005260:Female; D019398:Genes, BRCA1; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D020180:Heteroduplex Analysis; D006801:Humans; D008126:Lod Score; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D014157:Transcription Factors / Q000235:genetics
chemical_list: D024682:BRCA2 Protein; D005819:Genetic Markers; D009363:Neoplasm Proteins; D014157:Transcription Factors