title: Age group-associated variations in the pattern of Hp type distribution in Jordanians.
abstract: The relationship between haptoglobin (Hp) type and life expectancy was investigated by determining the pattern of Hp type distribution in 790 unrelated Jordanians divided into four age groups: A (1-19 years), B (20-39 years), C (40-59 years) and D (60-85 years). While the frequency of Hp 2-2 gradually decreased from 0.576 in A to 0.393 in D, the frequency of Hp 2-1 gradually increased from 0.348 in A to 0.526 in D. Hp2 allele decreased from 0.750 in A to 0.656 in D while that of Hpl allele increased from 0.250 in A to 0.344 in D. Hp type distribution in A, B and D age groups was in agreement with the Hardy-Weinberg equilibrium (HWE). These findings demonstrate that the pattern of Hp polymorphism varies in different age groups, indicating that life expectancy might be Hp phenotype-associated. Additionally, the results suggest that Hp 2-2 phenotype might be an age-associated risk factor.
authors.affiliation: Department of Biological Sciences, Hashemite University, P.O. Box 330077, 13133, Zarqa, Jordan.
authors.forename: M
authors.initials: M
authors.lastname: Hamad
authors.forename: S
authors.initials: S
authors.lastname: Awadallah
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D014644:Genetic Variation; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007223:Infant; D007597:Jordan; D008875:Middle Aged
chemical_list: D006242:Haptoglobins