Effects of lipids and antioxidants on PCB-mediated dysfunction of vascular endothelial cells (EC).
Our findings suggest that exposure to specific environmental contaminants can trigger diseases of the vasculature, e.g., cardiovascular disease. In addition, high-fat diets may potentiate and diets high in antioxidant nutrients may protect against PCB-mediated endothelial cell dysfunction. Our data give an insight into the potential use of vitamin E and related antioxidants to limit PCB-mediated cell injury. These studies are significant for providing new insights into potential nutrition interventions in diseases that can be induced by the toxicity of PCBs and other halogenated compounds.
Hennig
B
B
Department of Nutrition and Food Science, University of Kentucky, Lexington 40506 0054, USA. bhennig@pop.uky.edu
Slim
R
R
Toborek
M
M
Malecki
A
A
Robertson
L W
LW
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D005227:Fatty Acids / Q000494:pharmacology*; D011078:Polychlorinated Biphenyls / Q000037:antagonists & inhibitors / Q000633:toxicity*; D013552:Swine
D000975:Antioxidants; D005227:Fatty Acids; D011078:Polychlorinated Biphenyls