title: Effects of a novel fermented soy product on the serum lipids of hypercholesterolemic rabbits.
abstract: OBJECTIVE
  To assess the effect of a new feed soy product fermented by Enterococcus faecium and Lactobacillus jugurti on the serum lipid levels of rabbits with induced hypercholesterolemia.
  
  
  METHODS
  Thirty-two rabbits were divided into 4 groups as follows: 1) control (C); 2) hypercholesterolemic (H); 3) hypercholesterolemic + fermented product (HPF); and 4) control + fermented product (CPF). The H and HPF groups were fed with a diet with 0.15% (p/p) cholesterol in the first 15 days. C and CPF groups received regular food preparation. The HPF and CPF groups received 10 mL daily of the fermented 30 days. Blood samples were drawn at the beginning of the study and at the 15th and 30th days. Concentrations of total cholesterol, HDL-cholesterol, and triglycerides were analyzed.
  
  
  RESULTS
  After 15 days, the HPF group showed a total cholesterol concentration lower (18.4%) than that of the H group (p = 0.05), but this difference disappeared after 30 days. No change was observed in total cholesterol levels of C and CPF groups. After 15 days, the HDL-cholesterol was higher (17.8%) in the HPF group, but the triglyceride levels remained unchanged in all groups during the same period of time.
  
  
  CONCLUSIONS
  The soy fermented product caused an 18.4% reduction in total cholesterol and a 17.8% increase in the HDL-fraction. It may, therefore, be a possible coadjutor in the treatment of hypercholesterolemia.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Araraquara-UNESP, Brazil.
authors.forename: E A
authors.initials: EA
authors.lastname: Rossi
authors.forename: R C
authors.initials: RC
authors.lastname: Vendramini
authors.forename: I Z
authors.initials: IZ
authors.lastname: Carlos
authors.forename: I S
authors.initials: IS
authors.lastname: Ueiji
authors.forename: M M
authors.initials: MM
authors.lastname: Squinzari
authors.forename: S I
authors.initials: SI
authors.lastname: Silva Júnior
authors.forename: G F
authors.initials: GF
authors.lastname: Valdez
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D016984:Enterococcus faecium; D005285:Fermentation; D006937:Hypercholesterolemia / Q000628:therapy*; D007778:Lactobacillus; D008055:Lipids / Q000097:blood*; D008297:Male; D008517:Phytotherapy; D011817:Rabbits; D013025:Glycine max / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol