title: Mapping of a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26.
abstract: Nonspecific X-linked mental retardation is a heterogeneous condition consisting of nonsyndromal mental retardation in males. It is caused by mutation in one of several genes on the X chromosome (MRX genes). Here we report on the localization of a presumptive MRX gene to chromosomal region Xq24-q26 in a German family with nonspecific X-linked mental retardation (MRX 75, HUGO Human Gene Nomenclature Committee). Two point linkage analysis with 23 informative markers gave a lod score of 2.53 at theta = 0 for markers DXS425, DXS1254, DXS1114, and HPRT.
authors.affiliation: Medizinische Klinik I, Universität Bonn, Germany. caspari@uni-bonn.de
authors.forename: R
authors.initials: R
authors.lastname: Caspari
authors.forename: S
authors.initials: S
authors.lastname: Uhlhaas
authors.forename: W
authors.initials: W
authors.lastname: Friedl
authors.forename: M
authors.initials: M
authors.lastname: Knapp
authors.forename: P
authors.initials: P
authors.lastname: Propping
mesh_terms: D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D018911:Trinucleotide Repeats; D014960:X Chromosome
chemical_list: D005819:Genetic Markers