title: Totally implantable ventricular assist system that can increase brain blood flow.
abstract: In the clinical usage of the ventricular assist device (VAD), multiple organ failure becomes an important problem. To improve the clinical record of the VAD, another organ function may be vitally important. For that reason, we have been developing a VAD system aiming at improving another organ's function. Development of the vibrating flow pump (VFP), which can generate a very unique flow pattern from 10 Hz to 50 Hz, was ongoing in our Institute. In order to evaluate brain blood flow and oxygen consumption, HbO2 was measured with a NIRO monitoring device in healthy adult goats. Four goats were anesthetized with halothane inhalation; then left thoracotomy was performed for the left heart bypass. HbO2 of the brain was measured by recording of the hemodynamic variables during left heart assistance with the VFP system. During left heart bypass with the VFP system, hemodynamic parameters stayed within normal range, and satisfactory pump output was easily obtained. Pump output stayed within 20-40% bypass to evaluate the effect of high frequency oscillated assist flow on brain blood flow during the same cardiac output. Interesting results were observed during the experiments. During 30 Hz drive of the VFP left heart assistance, HbO2 suggested that brain blood flow significantly increased compared with another drive frequency assistance during the same total cardiac output. These results suggest that we can control the brain blood flow with a totally implantable VAD system such as the VFP system.
authors.affiliation: Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer;Graduate School of Engineering, Tohoku University, Japan. yambe@idac.tohoku.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Yambe
authors.forename: N
authors.initials: N
authors.lastname: Owada
authors.forename: S I
authors.initials: SI
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Yoshizawa
authors.forename: K I
authors.initials: KI
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Tabayashi
authors.forename: H
authors.initials: H
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
authors.forename: S I
authors.initials: SI
authors.lastname: Nitta
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004867:Equipment Design; D006041:Goats; D006353:Heart-Assist Devices; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen