Implication of interleukin-4 in wound healing.
Interleukin-4 (IL-4) is a pleiotropic cytokine that is able to activate connective tissue cells and stimulate the accumulation of extracellular matrix macromolecules. In this report, the expression of IL-4 in normal wound healing was studied by immunohistochemistry. The effects of exogenous IL-4 or IL-4 antisense oligonucleotides administration were also studied in mouse experimental wounds. IL-4 expression was detected in the lower dermis below the wound as early as Day 1 after wounding. IL-4 expression was maximal by Day 4, then decreased progressively, and completely disappeared by Day 21 after wounding. Topical administration of IL-4 on experimental wounds in mice significantly accelerated the rate of healing, whereas IL-4 antisense oligonucleotides significantly inhibited healing. These results demonstrate that IL-4 may be implicated in normal wound healing.
Salmon-Ehr
V
V
Laboratoire de Biochimie et Biologie Moléculaire, Faculté de Médecine, Reims, France.
Ramont
L
L
Godeau
G
G
Birembaut
P
P
Guenounou
M
M
Bernard
P
P
Maquart
F X
FX
D000818:Animals; D001483:Base Sequence; D015847:Interleukin-4 / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology*; D051379:Mice; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D014945:Wound Healing / Q000502:physiology*
D016376:Oligonucleotides, Antisense; D015847:Interleukin-4