Cell cycle. Replication meets cohesion. .
When a cell replicates its DNA during S phase of the cell cycle, the sister chromatid pairs must stick together like glue until they are separated to opposite ends of the cell (and hence into separate daughter cells) at anaphase. How the cell achieves this is still unclear but, as Takahashi and Yanagida explain in their Perspective, new findings in yeast have identified one molecule, Trf4p, that may be involved both in DNA replication and sister chromatid cohesion (Wang et al.).
Takahashi
K
K
Department of Gene Mechanisms, Graduate School of Biostudies, Kyoto University, Japan.
Yanagida
M
M
D000818:Animals; D002842:Chromatids / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism*; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000378:metabolism; D005800:Genes, Fungal; D009154:Mutation; D009687:Nuclear Proteins; D016196:S Phase; D004718:Saccharomycetales / Q000378:metabolism*
D002868:Chromosomal Proteins, Non-Histone; D005656:Fungal Proteins; D009687:Nuclear Proteins; D004259:DNA-Directed DNA Polymerase