Major metabolites of ginseng sapogenins formed by rat liver microsomes.
Incubation of ginseng sapogenins with microsomes from rat liver resulted in formation of their 20,24-epoxides as major metabolites. Identification of the metabolites was performed by HPLC, FAB-MS and EI-MS.
Kasai
R
R
Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University, Japan. rkasai@pharm.hiroshima-u.ac.jp
Hara
K
K
Dokan
R
R
Suzuki
N
N
Mizutare
T
T
Yoshihara
S
S
Yamasaki
K
K
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D008862:Microsomes, Liver / Q000378:metabolism*; D005894:Panax / Q000378:metabolism*; D010946:Plants, Medicinal; D051381:Rats; D012502:Sapogenins / Q000378:metabolism*
D012502:Sapogenins