Applications of genetically manipulated mice in pharmacogenetics and pharmacogenomics.
Gene knockout mice have proven to be very useful in understanding the role of xenobiotic-metabolizing enzymes in chemical toxicity and carcinogenesis. The combination of gene knockout technology with transgenic mouse technology should provide more versatile and suitable animal models to study the risks of chemical exposures in humans in terms of toxicity and carcinogenesis, as well as development and design of new therapeutic drugs. Recent studies using genetically manipulated mice are summarized.
Kimura
S
S
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. shioko@helix.nih.gov
Gonzalez
F J
FJ
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D010597:Pharmacogenetics / Q000379:methods*
D003577:Cytochrome P-450 Enzyme System