The quantification of technetium in generator-derived pertechnetate using ICP-MS.
Previous analytical methods employed to measure 99Tc:99mTc ratios in chromatographic 99mTc generators, derived from fission-based 99Mo, were limited in monitoring the ratios in low activity generators, over the extent of their elution regimes. For regulatory purposes, ICP-MS was employed to measure total technetium in generator eluates down to a level of 200 pg ml(-1) (200 ppt). Measured 99Tc:99mTc ratios compared very well with the theoretically computed values, ranging from 47:1 for a first elution of a generator with a long ingrowth time to 1.4:1 for the 17th elution of a generator with a short ingrowth time.
Hill
D M
DM
Australian Nuclear Science and Technology Organisation Menai, NSW.
Barnes
R K
RK
Wong
H K
HK
Zawadzki
A W
AW
D002138:Calibration; D002852:Chromatography, Ion Exchange / Q000379:methods; D005720:Gamma Rays; D013058:Mass Spectrometry / Q000379:methods; D013670:Sodium Pertechnetate Tc 99m / Q000737:chemistry*; D013667:Technetium / Q000032:analysis*
D013667:Technetium; D013670:Sodium Pertechnetate Tc 99m