Absence of Y chromosome microdeletions involving the DAZ (deleted in azoospermia) and RBM (ribonucleic acid-binding motif) genes in patients with chordee without hypospadias.
The presence or absence of 33 DNA loci was investigated with a focus on the long arm of Y chromosome (Yq) interval 6 involving the DAZ and RBM genes, by means of a polymerase chain reaction strategy, in 10 patients with hypospadias. All patients did not show any of the 33 DNA loci. It would appear that chordee without hypospadias does not involve interval 6 of the Y chromosome.
Tateno
T
T
Department of Urology, Yamagata University School of Medicine, Japan.
Sasagawa
I
I
Ashida
J
J
Nakada
T
T
Ogata
T
T
D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D000075364:Deleted in Azoospermia 1 Protein; D006801:Humans; D007021:Hypospadias; D008297:Male; D009687:Nuclear Proteins; D009845:Oligospermia / Q000235:genetics*; D010413:Penis / Q000002:abnormalities*; D016601:RNA-Binding Proteins / Q000235:genetics*; D014998:Y Chromosome
C095668:DAZ1 protein, human; D000075364:Deleted in Azoospermia 1 Protein; D009687:Nuclear Proteins; C501499:RBMY1A1 protein, human; D016601:RNA-Binding Proteins