Ethanol intake is not elevated in male 5-HT(1B) receptor knockout mice.
Recently, the phenotype of increased ethanol intake in mice lacking 5-HT(1B) receptors could not be replicated. We assessed ethanol consumption in male wildtype and 5-HT(1B) receptor knockout mice derived from the original population. Intake of water and ethanol (0%, 3%, 6%, 10% and 20% v/v) from two pipettes was determined daily for 40 days. Ethanol intake (g/kg body weight) did not differ between genotypes, while body weights (20-25%) and water intake (50%) were elevated in 5-HT(1B) receptor knockout mice. Hence, the initial finding of elevated ethanol intake in 5-HT(1B) receptor knockout mice may have been due to phenotypic differences in fluid intake.
Bouwknecht
J A
JA
Department of Psychopharmacology, Faculty of Pharmacy, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, Netherlands. j.a.bouwknecht@pharm.uu.nl
Hijzen
T H
TH
van der Gugten
J
J
Maes
R A
RA
Hen
R
R
Olivier
B
B
D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology; D000818:Animals; D001835:Body Weight; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage; D005838:Genotype; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000235:genetics*
D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D000431:Ethanol