Macronutrient intake and whole body protein metabolism following resistance exercise.
The provision of carbohydrate (CHO) supplements following resistance exercise attenuated muscle protein (PRO) degradation (Roy et al. J. Appl. Physiol. 82:1882-1888, 1997). The addition of PRO may have a synergistic effect upon whole body protein balance by increasing synthesis (Biolo et al. Am. J. Physiol. 273:E122-E129, 1997).


OBJECTIVE
To determine if the macronutrient composition of a postexercise beverage would alter muscle anabolism and/or catabolism following resistance exercise.


METHODS
We provided isoenergetic CHO (1 g x kg(-1)) and CHO/PRO/FAT supplements and placebo (PL) immediately (t = 0 h) and 1 h (t = + 1 h) following resistance exercise (9 exercises/3 sets/80% 1 RM) to 10 young, healthy, resistance-trained males. Whole body leucine turnover was determined from L-[1-13C]leucine kinetics at approximately 4 h postexercise.


RESULTS
No differences were observed for urinary 3-methylhistidine or urea nitrogen excretion between the trials. Leucine flux was significantly elevated at approximately 4 h postexercise for both CHO/PRO/FAT (177.59+/-12.68 micromol x kg(-1) x h(-1)) and CHO (156.18+/-7.77 micromol x kg(-1) x h(-1)) versus PL (126.32+/-10.51 micromol x kg(-1) x h(-1)) (P < 0.01). Whole body leucine oxidation was elevated at approximately 4 h for CHO/PRO/FAT (29.50+/-3.34 micromol x kg(-1) h(-1)) versus CHO (16.32+/-2.33 micromol x kg(-1) x h(-1)) (P < 0.01) and PL (21.29+/-2.54 micromol x kg(-1) x h(-1)) (P < 0.05). Nonoxidative leucine disposal (NOLD) was significantly elevated at approximately 4 h for both CHO/PRO/FAT (148.09+/-10.37 micromol x kg(-1) x h(-1)) and CHO (139.86+/-7.02 micromol x kg(-1) x h(-1)) versus PL (105.03+/-8.97 micromol x kg(-1) x h(-1)) (P < 0.01).


CONCLUSIONS
These results suggest that consumption of either CHO or CHO/PRO/FAT immediately and 1 h following a resistance training bout increased NOLD as compared with a placebo.
Roy
B D
BD
Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Fowles
J R
JR
Hill
R
R
Tarnopolsky
M A
MA
D000328:Adult; D001944:Breath Tests; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D004311:Double-Blind Method; D015444:Exercise; D006801:Humans; D008297:Male; D010919:Placebos; D011506:Proteins / Q000378:metabolism*; D014891:Weight Lifting / Q000502:physiology*
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D010919:Placebos; D011506:Proteins