Synthesis and hypoglycemic activity of some new flavone derivatives. 3rd communication: 3'-flavonyl-2,4-thiazolidinediones.
A new series of 3'-flavonyl-2,4-thiazolidinedione, 2,4-imidazolidinedione and 2-thiohydantoin derivatives (1-10) were synthesized and their chemical structures have been elucidated by various spectral data. The prepared compounds were tested for their insulinotropic effects in INS-1 cells. Inhibitory effects were observed for compounds 1 and 2. In contrast compounds 4, 7 and 8 were able to increase insulin release compared with glibenclamide.
Bozdağ
O
O
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
Verspohl
E J
EJ
Ertan
R
R
D000818:Animals; D002478:Cells, Cultured; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D051381:Rats; D013552:Swine
D005419:Flavonoids; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose