title: Disseminated intravascular coagulation and purpura fulminans secondary to infection.
abstract: Infection is one of the commonest causes of disseminated intravascular coagulation (DIC). DIC is a complex disorder that results from an imbalance of the pro- and anticoagulant regulatory pathways. This chapter will explain the cellular and molecular basis of the disorder and consider the rationale behind current and experimental treatment strategies.
authors.affiliation: Department of Paediatrics, Imperial College School of Medicine at St Mary's, Norfolk Place, London, W2 1PG, UK.
authors.forename: S N
authors.initials: SN
authors.lastname: Faust
authors.forename: R S
authors.initials: RS
authors.lastname: Heyderman
authors.forename: M
authors.initials: M
authors.lastname: Levin
mesh_terms: D001424:Bacterial Infections / Q000150:complications*; D001779:Blood Coagulation Factors / Q000378:metabolism; D016207:Cytokines / Q000009:adverse effects / Q000378:metabolism; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D011695:IgA Vasculitis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy
chemical_list: D001779:Blood Coagulation Factors; D016207:Cytokines