title: When not to give radiation therapy after breast conservation surgery for breast cancer.
abstract: OBJECTIVE
  A significant proportion of breast cancer patients treated with breast conservation surgery do not receive adjuvant radiation therapy because of advanced age, severe intercurrent disease, or their own preference. We studied patients for whom adjuvant radiation was not performed, to determine whether the rate of local recurrence was acceptable in particular clinical circumstances.
  
  
  METHODS
  Patients who had undergone breast conservation surgery for breast cancer were identified. The charts of patients who did not receive adjuvant radiation therapy were reviewed to identify the reason for omitting radiation. Local and distant recurrence rates were examined in relation to radiation and reason for omitting radiation.
  
  
  RESULTS
  Forty-three (9%, two bilateral) of the 487 patients did not receive radiation; 9 because of advanced age, 8 refused, 7 had severe intercurrent diseases, 6 developed stage IV disease while getting chemotherapy for stage III disease, 5 patients (1 bilateral) had two reasons for omission (3 cases: age + intercurrent disease; 2 cases: age + stage IV disease; and 1 case: age + small focus of ductal carcinoma in situ) and the remainder for miscellaneous reasons. None of the 13 patients with intercurrent disease or progression to stage IV disease developed local recurrence in their life time; 5 (63%) of 8 patients who refused radiation recurred in the breast; 2 (22%) 9 of the elderly patients developed local recurrences and none of the 6 cases with more than one reason for omission developed local recurrences.
  
  
  CONCLUSIONS
  Omission of radiation therapy after breast conservation is appropriate for patients with intercurrent diseases, for those who develop metastases while receiving preoperative chemotherapy and for selected elderly patients. Patients who refuse recommended adjuvant radiation therapy have unacceptably high rates of local recurrence. Omission of radiation for advanced age alone is associated with local recurrence rates comparable to those for younger patients.
authors.affiliation: Department of Surgery, The Mount Sinai Medical Center, New York, New York, USA.
authors.forename: J
authors.initials: J
authors.lastname: de Csepel
authors.forename: P I
authors.initials: PI
authors.lastname: Tartter
authors.forename: C
authors.initials: C
authors.lastname: Gajdos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology*; D018714:Radiotherapy, Adjuvant; D012042:Registries; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate