title: Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes.
abstract: The homeodomain transcription factor Nkx2-1 (TTF-1) plays an essential role in the development of the thyroid, lung and ventral forebrain. We report the cloning and developmental expression patterns of two Xenopus NK-2 genes, Nkx2-1 and Nkx2-4, that are closely related to Nkx2-1. These genes show readily distinguishable expression patterns during development. Similar to its orthologues in chicken and mouse, the Xenopus Nkx2-1 gene is expressed in the developing thyroid, lung, and ventral forebrain. In contrast, expression of Nkx2-4 is specifically localized to the ventral diencephalon.
authors.affiliation: Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, Tucson, AZ, 85724, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Small
authors.forename: S A
authors.initials: SA
authors.lastname: Vokes
authors.forename: R J
authors.initials: RJ
authors.lastname: Garriock
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: P A
authors.initials: PA
authors.lastname: Krieg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics*; D017403:In Situ Hybridization; D008168:Lung / Q000196:embryology; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics*; D016548:Prosencephalon / Q000196:embryology; D017386:Sequence Homology, Amino Acid; D013961:Thyroid Gland / Q000196:embryology; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000235:genetics*; D014981:Xenopus / Q000196:embryology* / Q000235:genetics*; D029867:Xenopus Proteins
chemical_list: D018398:Homeodomain Proteins; C000614414:Nkx2-1 protein, mouse; C485845:Nkx2-4 protein, Xenopus; C411247:Nkx2-4 protein, mouse; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D029867:Xenopus Proteins; C000614411:nkx2-1 protein, Xenopus