Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in human bone cell conditioned medium do not change with age.
We examined the effects of age on the secretion of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in long-term bone cell cultures from 71 female donors, aged 28-79 years. Our results suggest that under basal conditions, the intrinsic capacity of human bone cells to produce these IGF components is largely preserved with age.
Pfeilschifter
J
J
Kliniken Bergmannsheil, Department of Internal Medicine, University of Bochum, Bochum, Germany. johannes.pfeilschifter@ruhr-uni-bochum.de
Diel
I
I
Klöppinger
T
T
Bismar
H
H
Schuster
E M
EM
Balbach
S
S
Ziegler
R
R
Baylink
D
D
Mohan
S
S
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D005260:Female; D006801:Humans; D007085:Ilium / Q000166:cytology / Q000378:metabolism; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000378:metabolism*; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008875:Middle Aged
D017077:Culture Media, Conditioned; D018974:Insulin-Like Growth Factor Binding Protein 4; D018975:Insulin-Like Growth Factor Binding Protein 5; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II