title: Brugada-type electrocardiographic pattern induced by cocaine.
abstract: Right bundle branch block with coved ST-segment elevation in leads V1 through V3 is the electrocardiographic (ECG) marker of the Brugada syndrome. We describe a healthy young man with a normal baseline ECG in whom a transient Brugada pattern was observed repeatedly after recreational cocaine use. Intravenous administration of procainamide and subsequent intravenous propranolol followed by noradrenaline failed to reproduce the Brugada sign. An electrophysiologic study performed in the presence of the Brugada ECG pattern showed no inducible arrhythmias. This case illustrates that, in susceptible individuals, cocaine may provoke the Brugada sign. The clinical importance of this cocaine-induced ECG abnormality is currently unknown.
authors.affiliation: Department of Internal Medicine, Carolinas Medical Center, Charlotte, NC 28232, USA.
authors.forename: L
authors.initials: L
authors.lastname: Littmann
authors.forename: M H
authors.initials: MH
authors.lastname: Monroe
authors.forename: R H
authors.initials: RH
authors.lastname: Svenson
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D002037:Bundle-Branch Block / Q000139:chemically induced* / Q000503:physiopathology; D003042:Cocaine / Q000008:administration & dosage / Q000009:adverse effects*; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography / Q000187:drug effects; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D018765:Dopamine Uptake Inhibitors; D003042:Cocaine