title: Substituted oxygenated heterocycles and thio-analogues: synthesis and biological evaluation as melatonin ligands.
abstract: A new series of substituted oxygenated heterocycles and thio-analogues were synthesized and evaluated as melatonin receptor ligands. The replacement of the indolic moiety of melatonin by heterocyclic skeleton such as 1,4-benzodioxin, 2,3-dihydro-1,4-benzodioxin, chroman, 2,3-dihydro-1,4-benzoxathiin, thiochroman, carrying the amidic chain on the aromatic ring, leads to compounds showing a weak affinity for melatonin receptors, except for the compounds 1cb and 1hb.
authors.affiliation: Institut de Chimie Organique et Analytique, associé au CNRS, Université d'Orléans, France.
authors.forename: I
authors.initials: I
authors.lastname: Charton
authors.forename: A
authors.initials: A
authors.lastname: Mamai
authors.forename: C
authors.initials: C
authors.lastname: Bennejean
authors.forename: P
authors.initials: P
authors.lastname: Renard
authors.forename: E H
authors.initials: EH
authors.lastname: Howell
authors.forename: B
authors.initials: B
authors.lastname: Guardiola-Lemaître
authors.forename: P
authors.initials: P
authors.lastname: Delagrange
authors.forename: P J
authors.initials: PJ
authors.lastname: Morgan
authors.forename: M C
authors.initials: MC
authors.lastname: Viaud
authors.forename: G
authors.initials: G
authors.lastname: Guillaumet
mesh_terms: D000818:Animals; D002645:Chickens; D005069:Evaluation Studies as Topic; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008550:Melatonin / Q000378:metabolism*; D010100:Oxygen / Q000737:chemistry*; D013552:Swine
chemical_list: D006571:Heterocyclic Compounds; D008024:Ligands; D008550:Melatonin; D010100:Oxygen