[Involvement of ephrins and their receptors in oncogenesis].
Ephrins are membrane-linked ligands with an autocrine and/or immediate paracrine action. Ephrins were previously involved in embryonic neurogenesis, axonal guidance and/or retraction. Here, we will present data of the literature describing their roles in angiogenesis and in tumor progression. The capacity for ephrins to act in opposite directions will be discussed.
L'Allemain
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Institut de recherches signalisation, biologie du développement et cancer, CNRS UMR 6543, Centre de biochimie, Parc Valrose, 06108 Nice Cedex 2.
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D036387:Ephrin-B1; D036388:Ephrin-B2; D036389:Ephrin-B3; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D018919:Neovascularization, Physiologic
D036387:Ephrin-B1; D036388:Ephrin-B2; D036389:Ephrin-B3; D008565:Membrane Proteins; D009363:Neoplasm Proteins