Diversion of cytoskeletal processes by Shigella during invasion of epithelial cells.
Shigella, the causative agent of bacillar dysentery, invades colonic epithelial cells and moves intracellularly to spread from cell to cell. The processes of Shigella entry, determined by the Ipa proteins, and of actin-based motility, dependent on the IcsA/VirG protein, represent different levels of bacterial manipulation of the cell cytoskeleton.
Bourdet-Sicard
R
R
Unité de pathogénie microbienne moléculaire, Inserm U389, Institut Pasteur, Paris, France.
Egile
C
C
Sansonetti
P J
PJ
Tran Van Nhieu
G
G
D000199:Actins / Q000378:metabolism; D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004847:Epithelial Cells / Q000382:microbiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000382:microbiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D012760:Shigella / Q000378:metabolism / Q000472:pathogenicity* / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism; D016596:Vinculin / Q000378:metabolism; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; D020741:rho GTP-Binding Proteins / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
D000199:Actins; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; C495771:WASL protein, human; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; C058483:virG protein, Shigella flexneri; D016596:Vinculin; C092342:IpaC protein, Shigella; D019061:src-Family Kinases; D020741:rho GTP-Binding Proteins