[The role of superoxide in relationship between the cardiovascular diseases and the metabolic disorders associated with obesity].
Both cardiovascular diseases such as hypertension and atherosclerosis and metabolic disorders such as diabetes mellitus and hyperlipidemia are closely related with obesity. In recent studies, superoxide is supposed to play an important role in pathogenesis of the cardiovascular diseases. Superoxide inhibits the biological action of nitric oxide, known as endothelium-derived relaxing factor, leading to vasoconstriction. Moreover, superoxide directly affects the functions of endothelial cells and vascular smooth muscle cells. It has been investigated that the metabolic disorders associated with obesity enhance the superoxide production in the arterial walls through the insulin resistance. In hyperglycemic state, the production of superoxide is stimulated and the superoxide dimustase is inhibited by non-enzymatic glycation, known as Maillard reaction. Hyperlipidemia also increases endothelial superoxide production. Superoxide may act a key role in relationship between the cardiovascular diseases and the metabolic disorders associated with obesity.
Takahashi
K
K
Second Department of Internal Medicine, School of Medicine, Chiba University.
Saito
Y
Y
D006801:Humans; D007333:Insulin Resistance; D015416:Maillard Reaction; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D014661:Vasoconstriction
D013481:Superoxides; D009569:Nitric Oxide; D013482:Superoxide Dismutase