Amplification of the cyclin A gene in canine and feline mammary tumors.
DNAs from 33 canine mammary tumors and 8 feline mammary carcinomas were examined by Southern blot analysis to clarify genomic abnormalities of the cyclin A gene. Amplification of cyclin A was detected in 27.3% (9/33) of canine mammary tumors and 87.5% (7/8) of feline mammary carcinomas. It was suggested that amplification of cyclin A do not correlate directly with the tumorigenesis of canine mammary tumors, because there was no significant difference of incidence of cyclin A amplification between the benign and malignant tumors. In feline mammary carcinomas, the high frequency of cyclin A amplification raised the possibility that the amplification lead to the protein overexpression and play an important role in the tumorigenesis.
Murakami
Y
Y
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Japan.
Tateyama
S
S
Rungsipipat
A
A
Uchida
K
K
Yamaguchi
R
R
D000230:Adenocarcinoma / Q000235:genetics / Q000662:veterinary; D000236:Adenoma / Q000235:genetics / Q000662:veterinary; D000818:Animals; D015139:Blotting, Southern; D002371:Cat Diseases / Q000235:genetics*; D002415:Cats; D019925:Cyclin A / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D005784:Gene Amplification; D015674:Mammary Neoplasms, Animal / Q000235:genetics*; D015183:Restriction Mapping
D019925:Cyclin A; D004273:DNA, Neoplasm