title: Possible release of an ArgGlyArgProGln pentapeptide with innate immunity properties from acidic proline-rich proteins by proteolytic activity in commensal streptococcus and actinomyces species.
abstract: This study suggests degradation of salivary acidic proline-rich proteins (PRPs) into potential innate-immunity-like peptides by oral Streptococcus and Actinomyces species. PRP degradation paralleled cleavage of Pro-containing substrates. PRP degradation by S. gordonii strain SK12 instantly released a Pyr(1)-Pro(104)Pro(105) and a Gly(111)-Pro(149)Gln(150) peptide together with a presumed Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) pentapeptide. The synthetic Arg(106)Gly(107)Arg(108)Pro(109)Gln(110) peptide desorbed bound bacteria and counteracted sucrose-induced decrease of dental plaque pH in vitro.
authors.affiliation: Department of Cariology, Umeâ University, SE-901 87 Umeâ, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: P
authors.initials: P
authors.lastname: Bratt
authors.forename: A P
authors.initials: AP
authors.lastname: Jonsson
authors.forename: M
authors.initials: M
authors.lastname: Ryberg
authors.forename: I
authors.initials: I
authors.lastname: Johansson
authors.forename: W J
authors.initials: WJ
authors.lastname: Griffiths
authors.forename: T
authors.initials: T
authors.lastname: Bergman
authors.forename: N
authors.initials: N
authors.lastname: Strömberg
mesh_terms: D000190:Actinomyces / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009842:Oligopeptides / Q000276:immunology / Q000378:metabolism*; D010455:Peptides / Q000276:immunology / Q000378:metabolism*; D055232:Proline-Rich Protein Domains; D013291:Streptococcus / Q000378:metabolism*; D013379:Substrate Specificity; D020080:Tandem Repeat Sequences; D013997:Time Factors
chemical_list: D009842:Oligopeptides; D010455:Peptides