title: N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship.
abstract: Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.
authors.affiliation: Institute of Molecular Biology and Genetics NAS of Ukraine, Kiev. shved@imbig.kiev.ua
authors.forename: I
authors.initials: I
authors.lastname: Alexeeva
authors.forename: L
authors.initials: L
authors.lastname: Palchikovskaya
authors.forename: A
authors.initials: A
authors.lastname: Shalamay
authors.forename: L
authors.initials: L
authors.lastname: Nosach
authors.forename: V
authors.initials: V
authors.lastname: Zhovnovataya
authors.forename: O
authors.initials: O
authors.lastname: Povnitsa
authors.forename: N
authors.initials: N
authors.lastname: Dyachenko
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry*; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000737:chemistry*; D002460:Cell Line; D006801:Humans; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D000998:Antiviral Agents; D001374:Azacitidine; C040881:6-azacytidine