[International registry of liver tumors in liver transplantation. A registry update on hepatocellular carcinoma (HCC)].
In order to evaluate the impact of tumor characteristics on the outcome of survival following liver transplantation, a registry was established in 1992. The registry uses a mailout twice a year for initial reporting and for subsequent follow-up as the method of obtaining data. This report contains information from 644 patients from 57 institutions worldwide. Of those patients, 249 were alive and free of tumor, 27 patients were alive with tumor, 132 patients had died free of tumor and 139 patients had died with tumor. Of the deaths, half (135) were tumor related and 130 were non-tumor related. 97 patients' outcomes were not currently known. Factors influencing survival of HCC is the size of the tumor, multifocality, bilobar distribution, vascular invasion and tumor grade. In a Cox multivariate analysis tumor size of more than 5 cm, positive nodes and a poorly differentiated tumor were independent predictors of survival. The presence of an incidental tumor has a better prognosis than that of a non-incidental tumor; however, the difference is less than 10% at 5 years. Thus, an incidental hepatocellular carcinoma in a liver transplant patient should be treated as seriously and aggressively as a patient who was transplanted for the indication of a hepatocellular carcinoma.
Klintmalm
G B
GB
Baylor University Medical Center, Dallas, Texas 75246, USA.
D006528:Carcinoma, Hepatocellular / Q000401:mortality* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000401:mortality* / Q000473:pathology; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D015999:Multivariate Analysis; D012042:Registries; D012044:Regression Analysis; D013997:Time Factors