Atypical chronic myeloid leukaemia with trisomy 21 mosaicism as a sole chromosomal abnormality.
We present a 46-year-old patient with Ph-chromosome negative, bcr-negative chronic myeloid leukaemia (CML) in accelerated phase with a clonal trisomy 21 in the leukaemic blast cells. A rapid progress of disease with appearance of monocytosis is described, showing similar features to chronic myelomonocytic leukaemia (CMML). Heterogeneous characteristics and possible distinction of these two entities are discussed.
Benedek
D
D
First Department of Internal Medicine, University Hospital Köln, Germany.
Kiehl
M
M
Draube
A
A
Chemnitz
J
J
Diehl
V
V
Söhngen
D
D
D002891:Chromosomes, Human, Pair 21; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014314:Trisomy