title: Radiochemical separation of no-carrier-added 177Lu as produced via the 176Yb(n,gamma)177Yb-->177Lu process.
abstract: The 176Yb(n,gamma)177Yb-beta(-)-->177Lu process was investigated to provide no-carrier-added (nca) 177Lu. The radiochemical separation of the 177Lu from the macro-amounts of the ytterbium target based on the cementation process, i.e. the selective extraction of Yb by Na(Hg) amalgam from Cl-/CH3COO- electrolytes, followed by a final cation exchange purification. The cementation separation process provides a decontamination factor of Yb(III) of 10(4), the cation exchange purification adding a decontamination factor of > 10(2). The nca 177Lu is available in radiochemically pure form despite the chemical similarity of the lanthanides with 75 +/- 5% overall separation yield within 4-5 h. It can be used to synthesise nca 177Lu labelled radiotherapeuticals.
authors.affiliation: Laboratory for Nuclear Problems, JINR Dubna, Russian Federation.
authors.forename: N A
authors.initials: NA
authors.lastname: Lebedev
authors.forename: A F
authors.initials: AF
authors.lastname: Novgorodov
authors.forename: R
authors.initials: R
authors.lastname: Misiak
authors.forename: J
authors.initials: J
authors.lastname: Brockmann
authors.forename: F
authors.initials: F
authors.lastname: Rösch
mesh_terms: D002852:Chromatography, Ion Exchange / Q000379:methods; D007202:Indicators and Reagents; D007554:Isotopes; D008187:Lutetium / Q000737:chemistry* / Q000302:isolation & purification; D011868:Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D015018:Ytterbium / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D007554:Isotopes; D011868:Radioisotopes; D008187:Lutetium; D015018:Ytterbium