title: Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer.
abstract: Retinoblastoma has contributed much to the understanding of cancer. The protein product of the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle, differentiation and apoptosis in normal development of specific tissues. Elucidating the mechanisms in which pRB plays a critical role will enable novel therapies and strategies for prevention, not only for retinoblastoma, but for cancer in general.
authors.affiliation: Departments of Molecular and Medical Genetics, University of Toronto, Toronto, Canada.
authors.forename: D
authors.initials: D
authors.lastname: DiCiommo
authors.forename: B L
authors.initials: BL
authors.lastname: Gallie
authors.forename: R
authors.initials: R
authors.lastname: Bremner
mesh_terms: D016161:Genes, Retinoblastoma / Q000235:genetics*; D006801:Humans; D019572:Retinal Neoplasms / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics*; D016160:Retinoblastoma Protein / Q000235:genetics*
chemical_list: D016160:Retinoblastoma Protein