Angiotensin I converting enzyme polymorphism in humans with age-associated memory impairment: relationship with cognitive performance.
We compared the distribution of an insertion (I)/deletion (D) polymorphism coding for the angiotensin I converting enzyme (ACE) gene in 100 subjects fulfilling NIMH criteria for Age-associated memory impairment (AAMI) and 124 controls. We found significantly reduced prevalences of the ACE I/I genotype together with increases of the ACE D allele in the AAMI group. We further compared the neuropsychological performance of the AAMI group according to their ACE genotype. Those AAMI subjects presenting the ACE I/I genotype exhibited better performance on a measure of frontal lobe function. Our results suggest that the lack of the ACE I/I genotype and the presence of the ACE D allele are associated with memory impairment in the elderly.
Bartrés-Faz
D
D
Psychobiology Unit, Department of Psychiatry and Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, Catalunya, Spain. dbartres@psi.ub.es
Junqué
C
C
Clemente
I C
IC
López-Alomar
A
A
Valveny
N
N
López-Guillén
A
A
López
T
T
Cubells
M J
MJ
Moral
P
P
D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D000483:Alleles; D003071:Cognition / Q000502:physiology*; D005838:Genotype; D006801:Humans; D008569:Memory Disorders / Q000235:genetics* / Q000503:physiopathology* / Q000523:psychology; D008875:Middle Aged; D009483:Neuropsychological Tests; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011597:Psychomotor Performance / Q000502:physiology*; D012307:Risk Factors
D007703:Peptidyl-Dipeptidase A