[A clinical study of secondary osteoporosis induced by endocrine therapy for prostate cancer].
OBJECTIVE
There is one of the big problems that endocrine therapy for prostate cancer causes to induce secondary osteoporosis. The risk factors and future treatments for osteoporosis were investigated.


METHODS
31 patients treated with luteinizing hormone releasing hormone agonists (LHRH-a) or combination of chlormadinone acetate (CMA) and LHRH-a, and 19 patients with no treatments for prostate cancer were included in the analysis. Lumber spine bone mineral density (BMD) was measured by quantitative computed tomography.


RESULTS
Aging had much influence on decreases of BMD than the other risk factors (p < 0.01). There were statistically decreases of BMD in the patients with CMA + LHRH-a compared with no treatments (p < 0.05). Adrenal androgen which had an important role of maintenance in BMD was statistically decreased by the administration of CMA (p < 0.01).


CONCLUSIONS
Measurement of BMD before endocrine therapy is necessary for the patients with prostate cancer. It is important for the patients with decreases of BMD that CMA is not combined or the therapy for osteoporosis is preventively employed.
Furuta
A
A
Department of Urology, Kanagawa Prefectural Atsugi Hospital.
Yanada
S
S
Takizawa
A
A
Iwamuro
S
S
Suzuki
M
M
Tashiro
K
K
Hatano
T
T
Oishi
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000728:Androgens / Q000378:metabolism; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects; D002715:Chlormadinone Acetate / Q000009:adverse effects*; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects* / Q000819:agonists*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012307:Risk Factors
D000728:Androgens; D018931:Antineoplastic Agents, Hormonal; D002715:Chlormadinone Acetate; D007987:Gonadotropin-Releasing Hormone