Human Y chromosome, sex determination, and spermatogenesis- a feminist view.
In this review I want to argue that, far from being a macho entity with an all-powerful role in male development, the human Y chromosome is a "wimp." It is merely a relic of the X chromosome, and most or all of the genes it bears-including the genes that determine sex and control spermatogenesis-are relics of genes on the X chromosome that have other functions altogether.
Marshall Graves
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Department of Genetics, La Trobe University, Melbourne, Victoria 3083, Australia. j.graves@gen.latrobe.edu.au
D005075:Biological Evolution; D020223:Chromosome Painting; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D008297:Male; D019849:Sex Determination Processes; D012733:Sex Differentiation; D013091:Spermatogenesis / Q000235:genetics*; D014157:Transcription Factors; D014960:X Chromosome; D014998:Y Chromosome
D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors; C054430:ZFY protein, human