Characterization and mechanism of action of cerein 7, a bacteriocin produced by Bacillus cereus Bc7.
Cerein 7 is a peptidic antibiotic produced by Bacillus cereus Bc7 (CECT 5148) at the end of exponential growth but before sporulation onset. Cerein 7 has a broad spectrum of antibacterial activity against Gram-positive bacteria, but it is inactive against Gram-negative bacteria. The sequence of its amino-terminal end and its characteristics of hydrophobicity and molecular mass make cerein 7 unique among the bacteriocins produced by the soil bacterium B. cereus. In this paper a further characterization of cerein 7 is presented, it is shown that it can be classified as a Klaenhammer's class II bacteriocin and that its mode of action corresponds to that of a membrane-active compound.
Oscáriz
J C
JC
Departamento de Producción Agraria, Universidad Pública de Navarra, Pamplona, Spain.
Pisabarro
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AG
D001409:Bacillus cereus / Q000254:growth & development* / Q000378:metabolism; D001430:Bacteriocins / Q000145:classification / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D001433:Bacteriolysis; D015169:Colony Count, Microbial; D004305:Dose-Response Relationship, Drug; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests
D001430:Bacteriocins