Hormone replacement therapy and the risk of myocardial infarction in women with coronary risk factors.
To assess the risk of myocardial infarction in users of post-menopausal hormone replacement therapy who are at high risk of coronary disease because of hypertension, diabetes mellitus, or smoking, we used data from a previously published case-control study of women 45-74 years. After adjustment for age, ethnicity, and education, the odds ratio for myocardial infarction in current users of hormone replacement therapy was 0.9 (95% confidence interval (CI) = 0.5-1.6) in women with no major coronary risk factors, 0.8 (95% CI = 0.5-1.8) in women with one risk factor, and 1.1 (95% CI = 0.5-2.2) in women with two risk factors.
Petitti
D B
DB
Kaiser Permanente Medical Care Program, Southern California, Pasenda, CA, USA.
Sidney
S
S
Quesenberry
C P
CP
D000368:Aged; D002140:California / Q000453:epidemiology; D016022:Case-Control Studies; D048909:Diabetes Complications; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D016017:Odds Ratio; D017698:Postmenopause; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology