Schnitzler's syndrome: no evidence for autoimmune basis in two patients.
We report two cases of Schnitzler's syndrome in which anti-interleukin-1alpha autoantibodies and functional autoantibodies against the high affinity IgE receptor (FcepsilonRIalpha) or against IgE were absent. One patient responded well to TL-01 phototherapy, a treatment which may be considered in patients with Schnitzler's syndrome if, as is usually the case, they are unresponsive to antihistamine therapy.
Gallo
R
R
Professorial Unit, St. John's Institute of Dermatology, St. Thomas's Hospital, London, UK.
Sabroe
R A
RA
Black
A K
AK
Greaves
M W
MW
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007375:Interleukin-1 / Q000276:immunology*; D008875:Middle Aged; D010789:Phototherapy; D017455:Receptors, IgE / Q000276:immunology; D019873:Schnitzler Syndrome / Q000276:immunology* / Q000628:therapy; D016896:Treatment Outcome; D016312:Treatment Refusal
D001323:Autoantibodies; D007375:Interleukin-1; D017455:Receptors, IgE; D007073:Immunoglobulin E