Oxidative processes in Alzheimer's disease: the role of abeta-metal interactions.
Alzheimer's disease is characterized by signs of a major oxidative stress in the neocortex and the concomitant deposition of Amyloid beta (Abeta). Abeta is a metalloprotein that binds copper, and is electrochemically active. Abeta converts molecular oxygen into hydrogen peroxide by reducing copper or iron, and this may lead to Fenton chemistry. Hydrogen peroxide is a freely permeable prooxidant that may be responsible for many of the oxidative adducts that form in the Alzheimer-affected brain. The electrochemical activity of various Abeta species correlates with the peptides' neurotoxicity in cell culture, and participation in the neuropathology of Alzheimer's disease. These reactions present a novel target for Alzheimer therapeutics.
Lynch
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T
Department of Pathology, The University of Melbourne, and Neuropathology Laboratory, The Mental Health Research Institute of Victoria, Vic. 3052, Parkville, Australia.
Cherny
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RA
Bush
A I
AI
D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000502:physiology; D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D008670:Metals / Q000378:metabolism; D009498:Neurotoxins / Q000378:metabolism; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism
D016229:Amyloid beta-Peptides; D000975:Antioxidants; D008670:Metals; D009498:Neurotoxins; D017382:Reactive Oxygen Species