Tamoxifen for breast cancer prevention.
Tamoxifen is of proven efficacy in the treatment of breast cancer. New data indicate that it might be able to reduce the occurrence of receptor positive breast cancer when taken as a preventative. However trade-offs for this reduction are an increased incidence of endometrial carcinomas and thromboembolic events. Therefore the use of tamoxifen as preventative ought to be restricted to clinical studies or a well defined high risk situation. Whether raloxifen is superior to tamoxifen remains to be shown.
Breckwoldt
M
M
Department of Gynecology and Obstetrics II, Endocrinology and Reproduction Medicine, University of Freiburg, Germany.
Karck
U
U
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D016032:Randomized Controlled Trials as Topic; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*; D013629:Tamoxifen / Q000627:therapeutic use*
D018931:Antineoplastic Agents, Hormonal; D008055:Lipids; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen