[Immunology in the medical practice.XXXII. Transplantation of autologous hematopoietic stem cells for treatment of refractory auto-immune diseases; preliminary favorable results with 35 patients].
The objective of this study was to document the experiences in the first Dutch pilot studies of the effect of transplantation of autologous haematopoietic stem cells in patients with therapy-resistant autoimmune disease. The first results in 21 adults and 14 children are promising: remission of the disease was achieved in 13 patients, while in the others a significant reduction of disease activity was seen with a corresponding improvement of the quality of life. Infectious complications were frequently observed. Two children with systemic juvenile idiopathic arthritis developed a fatal infection-associated macrophage activation syndrome. Multicentre randomised studies are necessary to study the effects of autologous stem cell transplantation and modifications such as T-cell depletion.
Vlieger
A M
AM
Locatie Wilhelmina Kinderziekenhuis, afd. Immunologie, Universitair Medisch Centrum Utrecht.
van den Hoogen
F H
FH
Brinkman
D M
DM
van Laar
J M
JM
Schipperus
M
M
Kruize
A A
AA
Wulffraat
N M
NM
D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000601:surgery; D001327:Autoimmune Diseases / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000601:surgery; D008262:Macrophage Activation; D008297:Male; D009103:Multiple Sclerosis / Q000601:surgery; D009426:Netherlands; D010865:Pilot Projects; D012074:Remission Induction; D012595:Scleroderma, Systemic / Q000601:surgery; D013577:Syndrome; D019172:Transplantation Conditioning / Q000379:methods*; D014182:Transplantation, Autologous; D016896:Treatment Outcome