title: Racial differences in lipid metabolism in women with abdominal obesity.
abstract: We evaluated palmitate rate of appearance (R(a)) in plasma during basal conditions and during a four-stage epinephrine infusion plus pancreatic hormonal clamp in nine white and nine black women with abdominal obesity, who were matched on fat-free mass, total and percent body fat, and waist-to-hip circumference ratio. On the basis of single-slice magnetic resonance imaging analysis, black women had the same amount of subcutaneous abdominal fat but less intra-abdominal fat than white women (68 +/- 9 vs. 170 +/- 14 cm(2), P < 0.05). Basal palmitate R(a) was lower in black than in white women (1.95 +/- 0.26 vs. 2.88 +/- 0.23 micromol. kg fat-free mass(-1). min(-1), P < 0.005), even though plasma insulin and catecholamine concentrations were the same in both groups. Palmitate R(a) across a physiological range of plasma epinephrine concentrations remained lower in black women, because the increase in palmitate R(a) during epinephrine infusion was the same in both groups. We conclude that basal and epinephrine-stimulated palmitate R(a) is lower in black than in white women with abdominal obesity. The differences in basal palmitate kinetics are not caused by alterations in plasma insulin or catecholamine concentrations or lipolytic sensitivity to epinephrine. The lower rate of whole body fatty acid flux and smaller intra-abdominal fat mass may have clinical benefits because of the relationship between excessive fatty acid availability and metabolic diseases.
authors.affiliation: Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: S B
authors.initials: SB
authors.lastname: Racette
authors.forename: J F
authors.initials: JF
authors.lastname: Horowitz
authors.forename: B
authors.initials: B
authors.lastname: Mittendorfer
authors.forename: S
authors.initials: S
authors.lastname: Klein
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D044383:Black People; D001823:Body Composition; D002250:Carbon Radioisotopes; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008066:Lipolysis / Q000502:physiology; D009765:Obesity / Q000208:ethnology* / Q000378:metabolism*; D019308:Palmitic Acid / Q000493:pharmacokinetics*; D010179:Pancreas / Q000378:metabolism; D013566:Sympathomimetics / Q000097:blood / Q000494:pharmacology; D044465:White People
chemical_list: D002250:Carbon Radioisotopes; D007328:Insulin; D013566:Sympathomimetics; D019308:Palmitic Acid; D004837:Epinephrine