N4-amino-acid derivatives of 6-azacytidine: structure-activity relationship.
Several N4-derivatives of 6-azacytidine were synthesized using of Vorbrüggen's condensation method. Their antiviral activity with respect to the adenovirus serotypes 2 and 5 in Hep-2 cells culture was studied and primary specific activity was determined. Correlation between chemical structure of new 6-azacytidine derivatives and their biological properties is discussed.
Alexeeva
I
I
Institute of Molecular Biology and Genetics NAS of Ukraine, Kiev. shved@imbig.kiev.ua
Palchikovskaya
L
L
Shalamay
A
A
Nosach
L
L
Zhovnovataya
V
V
Povnitsa
O
O
Dyachenko
N
N
D000596:Amino Acids / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry*; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000737:chemistry*; D002460:Cell Line; D006801:Humans; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000596:Amino Acids; D000998:Antiviral Agents; D001374:Azacitidine; C040881:6-azacytidine