title: Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine.
abstract: We examined the effect of sulfapyridine on mast cell-mediated immediate-type allergic reactions. Sulfapyridine (1 and 10 microg/kg) significantly inhibited systemic allergic reaction induced by compound 48/80 in rats. Sulfapyridine (1 and 10 microg/kg) also inhibited significantly local mast cell-mediated immediate-type allergic reactions activated by anti-dinitrophenyl (DNP) IgE. Moreover, sulfapyridine inhibited histamine release dose-dependently in the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. When sulfapyridine was added, the level of cAMP in RPMC, transiently and significantly increased about 4-fold compared with that of basal cells. These results indicate that sulfapyridine inhibits mast cell-mediated immediate-type allergic reactions in vivo and in vitro.
authors.affiliation: College of Pharmacy, Professional Graduate School of Oriental Medicine, Center of Oriental Medicinal Science, Wonkwang University, Iksan, Chonbuk, South Korea. hmkim@wonnms.wonkwang.ac.kr
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: N H
authors.initials: NH
authors.lastname: An
authors.forename: B H
authors.initials: BH
authors.lastname: Yi
authors.forename: H J
authors.initials: HJ
authors.lastname: Chae
authors.forename: H R
authors.initials: HR
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Moon
authors.forename: J J
authors.initials: JJ
authors.lastname: Kim
authors.forename: S T
authors.initials: ST
authors.lastname: Park
authors.forename: S H
authors.initials: SH
authors.lastname: Baek
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004140:Dinitrophenols / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000276:immunology; D013427:Sulfapyridine / Q000494:pharmacology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D004140:Dinitrophenols; D012709:Serum Albumin; C058064:dinitrophenyl-human serum albumin conjugate; D003189:p-Methoxy-N-methylphenethylamine; D000242:Cyclic AMP; D013427:Sulfapyridine