Photodynamic therapy for esophageal cancer. Update.
Although clinical studies with photodynamic therapy have been conducted for over 25 years, only recently has this technique become widely available for the treatment of esophageal cancer. Studies have demonstrated that it is as effective as Nd:YAG therapy for advanced esophageal malignancies while technically being somewhat easier to perform. Preliminary studies in early esophageal cancer also show effectiveness. In many ways, PDT is still in its infancy, and its exact role compared to other endoscopic treatments of esophageal cancer remains to be defined. It is expected that the development of new photosensitizers and light delivery systems will further expand the role of PDT in the diagnosis and management of esophageal neoplasms.
Greenwald
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BD
Division of Gastroenterology, University of Maryland Medical Center, Baltimore, USA. bgreenwa@medicine.umaryland.edu
D000818:Animals; D001471:Barrett Esophagus / Q000188:drug therapy; D017323:Dihematoporphyrin Ether / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011524:Protoporphyrins / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D017319:Photosensitizing Agents; D011524:Protoporphyrins; D017323:Dihematoporphyrin Ether; C028025:protoporphyrin IX