title: Decreased expression of CD44, alpha-catenin, and deleted colon carcinoma and altered expression of beta-catenin in ulcerative colitis-associated dysplasia and carcinoma, as compared with sporadic colon neoplasms.
abstract: BACKGROUND
  To clarify the cell adhesion status in ulcerative colitis (UC)-associated colon neoplasm, expression of cell adhesion molecules were investigated and compared with that of sporadic colon neoplasm.
  
  
  METHODS
  A total of 14 low grade dysplasias, 16 high grade dysplasias, and 8 adenocarcinomas associated with UC and 17 sporadic adenomas with mild to moderate dysplasia, 22 adenomas with severe dysplasia, and 15 invasive adenocarcinomas were immunohistochemically examined using monoclonal antibodies against CD44, E-cadherin, alpha- and beta-catenin, and deleted colon carcinoma (DCC).
  
  
  RESULTS
  CD44, especially its standard form, and DCC expression was stronger in the sporadic colon neoplasms than in the UC-associated lesions. Although E-cadherin did not show significant differences between the two cases, alpha-catenin was more expressed in sporadic colon adenomas with severe dysplasia and carcinomas than in their UC-associated counterparts. Membranous beta-catenin staining was stronger in UC-associated neoplasms, whereas sporadic lesions had greater cytoplasmic and nuclear expression.
  
  
  CONCLUSIONS
  The differences in cell adhesion molecule expression suggests that UC-associated and sporadic colon neoplasms arise from different pathways of tumorigenesis.
authors.affiliation: Department of Pathology, School of Medicine, Kitasato University, Sagamihara, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mikami
authors.forename: H
authors.initials: H
authors.lastname: Mitomi
authors.forename: A
authors.initials: A
authors.lastname: Hara
authors.forename: N
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: O
authors.initials: O
authors.lastname: Tsuruta
authors.forename: I
authors.initials: I
authors.lastname: Okayasu
mesh_terms: D015820:Cadherins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D003110:Colonic Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000096:biosynthesis* / Q000378:metabolism*; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D007150:Immunohistochemistry; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin
chemical_list: C495273:CTNNA1 protein, human; C495270:CTNNB1 protein, human; D015820:Cadherins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D018960:Hyaluronan Receptors; D015534:Trans-Activators; D051178:alpha Catenin; D051176:beta Catenin