Significance of chemokines and activated platelets in patients with diabetes.
Levels of platelet-derived microparticles (PMPs), platelet activation markers (P-selectin expressed on, or annexin V binding to, platelets (plt:P-selectin or plt:annexin V, respectively)), chemokines (IL-8, monocyte chemotactic peptide-1 (MCP-1), and regulated on activation normally T-cell expressed and secreted (RANTES)), and soluble P- and E-selectins were compared in peripheral blood from diabetic and control patients in order to develop a better understanding of their potential contribution to diabetic vascular complications. Significant increases were found for PMPs, plt:P-selectin, MCP-1, RANTES and soluble P- and E-selectins in diabetic individuals, whereas IL-8 levels were similar. Furthermore, after ticlopidine treatment, most of these factors receded to baseline levels observed in non-diabetic patients. Our findings indicate that ticlopidine might be able to prevent or reduce vascular complications in diabetic patients.
Nomura
S
S
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan. fwkg4681@mb.infoweb.ne.jp
Shouzu
A
A
Omoto
S
S
Nishikawa
M
M
Fukuhara
S
S
D000328:Adult; D017304:Annexin A5 / Q000097:blood; D001792:Blood Platelets / Q000276:immunology / Q000378:metabolism; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood; D018946:Chemokine CCL5 / Q000097:blood; D018925:Chemokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000276:immunology*; D003925:Diabetic Angiopathies / Q000517:prevention & control; D019040:E-Selectin / Q000097:blood; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D015539:Platelet Activation; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D013988:Ticlopidine / Q000494:pharmacology
D017304:Annexin A5; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D018925:Chemokines; D019040:E-Selectin; D016209:Interleukin-8; D019007:P-Selectin; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine