Tumor necrosis factor, interleukin-6,and epinephrine are associated with hypermetabolism in AIDS patients with acute opportunistic infections.
During a 9-day period we investigated body composition, resting energy expenditure (REE), IL-6, TNF, and sTNFR-55 and sTNFR-75 plasma concentrations during infectious complications in 12 patients with HIV disease. At study entry, IL-6 was detectable in 5 and TNF in 10 patients. TNF was closely correlated with sTNFR-75 concentration (r = 0.84, p < 0.001) whereas sTNFR/sTNFR-55 ratio increased throughout the study. TNF concentrations were significantly correlated with the 24-hour excretion of epinephrine and norepinephrine (r = 0.64 and 0.69; each p < 0.01). Compared to expected values REE was increased by 34%. Body cell mass was the single best predictor of REE and explained 72% of its variance. In contrast, the deviation of measured from predicted REE was correlated with TNF and IL-6 concentrations (r = 0.9). We conclude that increased plasma concentrations of cytokines in complicated HIV disease display little biologic variability and relate to hypermetabolism in these patients.
Süttmann
U
U
Zentrum Innere Medizin und Dermatologie, Abteilung Klinische Immunologie, Basel, Switzerland.
Holtmannspötter
M
M
Ockenga
J
J
Gallati
H
H
Deicher
H
H
Selberg
O
O
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000378:metabolism; D000328:Adult; D001823:Body Composition; D004734:Energy Metabolism; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015850:Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D004837:Epinephrine