title: Preparation and characterization of cholic acid-derived antimicrobial agents with controlled stabilities.
abstract: [reaction: see text] Novel cholic acid-derived antimicrobial agents that decompose under mildly basic conditions have been prepared. These compounds range in biological properties from potent antibacterial activity to effective permeabilization of the outer membranes of Gram-negative bacteria.
authors.affiliation: Departments of Chemistry and Biochemistry and Microbiology, Brigham Young University, Provo, Utah 84602, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Guan
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: E J
authors.initials: EJ
authors.lastname: Schmidt
authors.forename: J S
authors.initials: JS
authors.lastname: Boswell
authors.forename: J P
authors.initials: JP
authors.lastname: Walsh
authors.forename: G W
authors.initials: GW
authors.lastname: Allman
authors.forename: P B
authors.initials: PB
authors.lastname: Savage
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D002793:Cholic Acids / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D004355:Drug Stability; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D002793:Cholic Acids