Acute painful diabetic neuropathy: two patients with recent insulin-dependent diabetes mellitus.
Two young men developed an acute painful peripheral neuropathy a few weeks after being diagnosed to suffer from an insulin-dependent diabetes mellitus. In both cases, peripheral nerve biopsy exhibited a few features of acute axonal degeneration. Additionally, in the first case there was a lymphocytic infiltrate around an endoneurial capillary, and in the second case there were several mast cells in the endoneurium of every fascicle examined. A few months later, the acute pain had disappeared in both cases. Only a few cases of acute painful diabetic neuropathy have been reported so far. A vascular origin seems unlikely and metabolic disorders are probably due to a contemporary severe weight loss. An auto-immune mechanism is an alternative explanation.
Vital
C
C
Neuropathology and Anatomic Pathology Laboratory, Victor Segalen University, Bordeaux, France.
Vital
A
A
Dupon
M
M
Gin
H
H
Rouanet-Larriviere
M
M
Lacut
J Y
JY
D000208:Acute Disease; D000328:Adult; D001369:Axons / Q000473:pathology; D002196:Capillaries / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009410:Nerve Degeneration / Q000473:pathology; D010146:Pain / Q000503:physiopathology; D010525:Peripheral Nerves / Q000098:blood supply / Q000473:pathology