Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1.
Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicate in the human thymus in vivo. In this model, however, the presence of one virus appears not to modify the replication or cytopathicity of the other.
Gobbi
A
A
Unit of Human Virology, Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy.
Stoddart
C A
CA
Locatelli
G
G
Santoro
F
F
Bare
C
C
Linquist-Stepps
V
V
Moreno
M E
ME
Abbey
N W
NW
Herndier
B G
BG
Malnati
M S
MS
McCune
J M
JM
Lusso
P
P
D000818:Animals; D003588:Cytopathogenic Effect, Viral; D004268:DNA-Binding Proteins / Q000032:analysis; D005434:Flow Cytometry; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006566:Herpesviridae Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D016513:Mice, SCID; D013601:T-Lymphocytes / Q000821:virology; D014764:Viral Proteins / Q000032:analysis; D014779:Virus Replication
D004268:DNA-Binding Proteins; D016655:HIV Core Protein p24; D014764:Viral Proteins; C081690:p41 protein, Human herpesvirus 6