title: The incidence of positive margins with breast conserving therapy following mammotome biopsy for microcalcification.
abstract: OBJECTIVE
  The ability to achieve clean margins with breast conserving therapy varies greatly even when the diagnosis of carcinoma is known beforehand. Although several reports reveal that the incidence of positive margins decreases after stereotaxic core biopsy of nonpalpable lesions and fine-needle aspiration biopsy of palpable lesions, the data on the results following mammotome biopsy (mmbx) is scanty.
  
  
  METHODS
  Two hundred and ninety-eight biopsy specimens for mammographically indeterminate microcalcification from 1/97 through 3/30/98 were reviewed. Biopsies were performed using the biopsys method utilizing an 11-gauge multidirectional, vacuum-directed device.
  
  
  RESULTS
  Ten percent (n = 31) of the mammotome biopsies were atypical and 9% (n = 27) were malignant. These 58 cases (19%) were recommended for surgical excision. The incidence of positive margins in this subset was determined. Of patients who underwent lumpectomy as their initial surgical procedure 69% had negative surgical margins. Seventy-seven percent of patients with carcinoma diagnosed by mammotome biopsy had definitive initial surgery with a single surgical procedure.
  
  
  CONCLUSIONS
  Mmbx facilitates fewer surgical procedures to achieve negative margins, and thus provides a better cosmetic result.
authors.affiliation: Department of Pathology, New York University Medical Center, New York, New York 110016, USA> joan.cangiarella@nyu.med.edu
authors.forename: J
authors.initials: J
authors.lastname: Cangiarella
authors.forename: J
authors.initials: J
authors.lastname: Gross
authors.forename: W F
authors.initials: WF
authors.lastname: Symmans
authors.forename: J
authors.initials: J
authors.lastname: Waisman
authors.forename: B
authors.initials: B
authors.lastname: Petersen
authors.forename: D
authors.initials: D
authors.lastname: D'Angelo
authors.forename: C
authors.initials: C
authors.lastname: Singer
authors.forename: D
authors.initials: D
authors.lastname: Axelrod
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D002114:Calcinosis / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D012307:Risk Factors; D012680:Sensitivity and Specificity