Prognostic significance of tissue DF3 antigen and CA15-3 tumor marker in primary breast cancer.
The specific monoclonal antibody, DF3, for breast cancer and the corresponding tumor marker CA15-3 were evaluated in 108 patients with primary cancer of the breast. These antigens correlated poorly with the known prognostic parameters. Elevated CA15-3 serum values were associated with the cytoplasmic distribution of the DF3 antigen in the cell. The DF3 distribution pattern and the CA15-3 serum values had prognostic significance for disease-free interval.
Dimas
C
C
Biochemistry-Microbiology Department, Areteion Hospital Medical School, Athens, Greece.
Fragos-Plemenos
M
M
Gennatas
C
C
Kouskouni
E
E
Kondi-Paphitis
A
A
D000911:Antibodies, Monoclonal / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018396:Mucin-1 / Q000032:analysis* / Q000097:blood; D011379:Prognosis
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D018396:Mucin-1