Nitrite/nitrate (NOx) levels and hemodynamics during septic shock.
Nitric oxide (NO) acts as a vasorelaxant. We investigated the relationship between nitrite/nitrate (NOx), which are the final metabolites of NO, and hemodynamics during septic shock. We also examined tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), and endotoxin. A significant negative correlation was observed between NOx levels and pulmonary capillary wedge pressure (PCWP; r = -0.6075, P = 0.0028). A significant positive correlation was noted between NOx levels and the cardiac index (CI; r = 0.5934, P = 0.0038). A significant negative correlation was found between NOx levels and the systemic vascular resistance index (SVRI; r = -0.4354, P = 0.0485). A significant positive correlation was observed between NOx levels and the stroke volume index (SVI; r = 0.5040, P = 0.0186). A significantly close positive correlation was also observed between TNF-alpha levels and NOx levels (r = 0.7848, P < 0.0001). These findings suggest that NOx levels are closely associated with hemodynamics during septic shock, resulting in a vascular relaxing effect.
Nakae
H
H
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Endo
S
S
Kikuchi
M
M
Yamada
Y
Y
Shibata
M
M
Ishikura
H
H
Tanaka
T
T
Wakabayashi
G
G
Kawamura
T
T
Inada
K
K
Sato
S
S
D000328:Adult; D000368:Aged; D004731:Endotoxins / Q000032:analysis* / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000032:analysis; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000032:analysis; D012044:Regression Analysis; D012772:Shock, Septic / Q000503:physiopathology*; D013318:Stroke Volume; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis* / Q000494:pharmacology; D014655:Vascular Resistance
D004731:Endotoxins; D016209:Interleukin-8; D009566:Nitrates; D009573:Nitrites; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide