Molecular mechanisms of Salmonella invasion: the type III secretion system of the pathogenicity island 1.
Salmonella spp. are facultative intracellular pathogens which are able to enter into non-phagocytic cells as an essential step in their pathogenic life cycle. The majority of the molecular determinants involved in this entry process are encoded in a pathogenicity island located at the centisome 63 of the bacterial chromosome, and belong to a specialized protein secretion system termed "type III" or "contact-dependent". This secretion system is used by Salmonella spp. and several other bacterial pathogens to translocate bacterial effector proteins into the eukaryotic cell. Thus, a bidirectional biochemical cross-talk with the host cell is initiated, which leads to several responses such as membrane ruffling, bacterial internalization and the activation of various transcription factors.
Suárez
M
M
Departamento de Patología Animal I, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain. msuarez@eucmax.sim.ucm.es
Rüssmann
H
H
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002876:Chromosomes, Bacterial / Q000235:genetics; D012475:Salmonella / Q000378:metabolism* / Q000472:pathogenicity*; D014774:Virulence
D001426:Bacterial Proteins