title: Serum ferritin in healthy subjects and type 2 diabetic patients.
abstract: In order to study the relationship between the serum ferritin level and the components of the insulin resistance syndrome in type 2 diabetic patients, we evaluated fifty type 2 diabetic patients who were selected according to NDDG/WHO criteria from those patients attending Korea University Hospital from 1997 to 1998. Twenty-five healthy non-diabetic subjects of comparable age and sex distribution acted as a control group. The results showed that the value of log ferritin was higher in the type 2 diabetes patients than the control subjects, but not at a statistically significant level (p = 0.09). Log ferritin was correlated with fasting blood sugar level (r = 0.235, p = 0.048) and body mass index (BMI) (r = 0.285, p = 0.05). In the type 2 diabetic patients, log ferritin was correlated with fasting C-peptide (r = 0.478, p = 0.009). In the control subjects, log ferritin was correlated only with BMI (r = 0.477, p = 0.012). In a stepwise multiple regression analysis, the diabetic group showed a significant correlation between fasting C-peptide and log ferritin (p = 0.001). In the control group, the fasting sugar level was significantly correlated with log ferritin (p = 0.034). These results suggest that serum ferritin can be employed as a marker of not only glucose homeostasis but also insulin resistance both in type 2 diabetic and control subjects.
authors.affiliation: Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.
authors.forename: N H
authors.initials: NH
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Oh
authors.forename: K M
authors.initials: KM
authors.lastname: Choi
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Baik
authors.forename: D S
authors.initials: DS
authors.lastname: Choi
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D002241:Carbohydrates / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D002096:C-Peptide; D002241:Carbohydrates; D005293:Ferritins