title: Sarcoidosis and dermatomyositis in a patient with hemoglobin SC. A case report and literature review.
abstract: Although sarcoidosis has occasionally been associated with hemoglobinopathies, its association with dermatomyositis is extremely rare. A 24 y/o African American male with hemoglobin SC disease developed proximal weakness. He had heliotrope rash, muscle weakness, elevated serum CK, myositis by EMG, and no malignancy. A muscle biopsy confirmed dermatomyositis. Two years later, he was hospitalized with constitutional and respiratory symptoms and parotid enlargement. Chest X-ray and CT scan showed diffuse micronodular infiltration in both lungs and mediastinal lymphadenopathy. A transbronchial lung biopsy revealed non-caseating granulomata consistent with sarcoidosis. AFB and fungal stains and cultures were negative. Thus, in this case, sarcoidosis developed after or in association with dermatomyositis. A review of world's literature showed five other non-identical cases of dermatomyositis associated with sarcoidosis.
authors.affiliation: Department of Medicine, Huron Hospital, Cleveland, Ohio 44112, USA. abrateanu@hotmail.com
authors.forename: A C
authors.initials: AC
authors.lastname: Brateanu
authors.forename: A
authors.initials: A
authors.lastname: Caracioni
authors.forename: H R
authors.initials: HR
authors.lastname: Smith
mesh_terms: D000328:Adult; D001706:Biopsy; D003882:Dermatomyositis / Q000150:complications* / Q000503:physiopathology; D003937:Diagnosis, Differential; D006450:Hemoglobin SC Disease / Q000150:complications*; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D018908:Muscle Weakness; D013902:Radiography, Thoracic; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology