title: Factors affecting African-American participation in AIDS research.
abstract: BACKGROUND
  Although African Americans are disproportionately affected by the AIDS epidemic, they are underrepresented in AIDS research, particularly in AIDS clinical trials. This study examines a multidimensional construct of distrust and other factors that may affect willingness to participate in AIDS research.
  
  
  METHODS
  A total of 301 African Americans (aged >/=18 years) in Durham, North Carolina participated in a cross-sectional survey. In-person interviews, 20 to 25 minutes in length, were conducted with participants. Structural equation modeling was used to develop models exploring distrust and other factors affecting willingness to participate in AIDS research among African Americans.
  
  
  RESULTS
  Distrust was the strongest inverse predictor of willingness to participate in AIDS clinical trials. Distrust was not significantly associated with willingness to participate in AIDS surveys and educational interventions. Altruism, facilitators/barriers, religiosity, and economic group membership were also significantly associated with willingness to participate in AIDS clinical trials. Only altruism was significantly associated with willingness to participate in AIDS surveys and educational interventions.
  
  
  CONCLUSIONS
  Distrust about research institutions is a significant barrier to recruiting African Americans in AIDS clinical trials. Issues of distrust need to be acknowledged by researchers to develop better recruitment and retention strategies when conducting AIDS clinical trials in African-American communities.
authors.affiliation: Center for AIDS Prevention Studies, University of California, San Francisco, California 94105, USA. ssengupta@psg.ucsf.edu
authors.forename: S
authors.initials: S
authors.lastname: Sengupta
authors.forename: R P
authors.initials: RP
authors.lastname: Strauss
authors.forename: R
authors.initials: R
authors.lastname: DeVellis
authors.forename: S C
authors.initials: SC
authors.lastname: Quinn
authors.forename: B
authors.initials: B
authors.lastname: DeVellis
authors.forename: W B
authors.initials: WB
authors.lastname: Ware
mesh_terms: D000163:Acquired Immunodeficiency Syndrome; D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000523:psychology*; D000533:Altruism; D001294:Attitude to Health / Q000208:ethnology*; D002986:Clinical Trials as Topic; D003430:Cross-Sectional Studies; D006306:Health Surveys; D006801:Humans; D009657:North Carolina; D011641:Public Relations; D012067:Religion; D012107:Research Design; D011795:Surveys and Questionnaires; D014481:United States