title: De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.
authors.affiliation: Department of Chemistry, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA. blagu@prius.jnj.com
authors.forename: B
authors.initials: B
authors.lastname: Lagu
authors.forename: D
authors.initials: D
authors.lastname: Tian
authors.forename: Y
authors.initials: Y
authors.lastname: Jeon
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: J M
authors.initials: JM
authors.lastname: Wetzel
authors.forename: D
authors.initials: D
authors.lastname: Nagarathnam
authors.forename: Q
authors.initials: Q
authors.lastname: Shen
authors.forename: C
authors.initials: C
authors.lastname: Forray
authors.forename: R S
authors.initials: RS
authors.lastname: Chang
authors.forename: T P
authors.initials: TP
authors.lastname: Broten
authors.forename: R W
authors.initials: RW
authors.lastname: Ransom
authors.forename: T B
authors.initials: TB
authors.lastname: Chan
authors.forename: S S
authors.initials: SS
authors.lastname: O'Malley
authors.forename: T W
authors.initials: TW
authors.lastname: Schorn
authors.forename: A D
authors.initials: AD
authors.lastname: Rodrigues
authors.forename: K
authors.initials: K
authors.lastname: Kassahun
authors.forename: D J
authors.initials: DJ
authors.lastname: Pettibone
authors.forename: R O
authors.initials: RO
authors.lastname: Freidinger
authors.forename: C
authors.initials: C
authors.lastname: Gluchowski
mesh_terms: D000284:Administration, Oral; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology; D001667:Binding, Competitive; D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010080:Oxazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D011312:Pressure; D011467:Prostate / Q000187:drug effects / Q000502:physiology; D011869:Radioligand Assay; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects*; D011994:Recombinant Proteins / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology; D014521:Urethra / Q000187:drug effects / Q000502:physiology
chemical_list: C547713:ADRA1A protein, human; D000317:Adrenergic alpha-Antagonists; D010080:Oxazoles; D018340:Receptors, Adrenergic, alpha-1; D011994:Recombinant Proteins; C412726:SNAP 7915