Synergistic effect of amantadine and imipramine in the forced swimming test.
The obtained results indicate that joint administration of amantadine (a non-competitive NMDA receptor antagonist) and imipramine induced antidepressant-like effect in the forced swimming test even at doses of both drugs which were ineffective when each of the drugs was used alone.
Maj
J
J
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Rogóz
Z
Z
D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D004357:Drug Synergism; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013550:Swimming / Q000523:psychology
D000929:Antidepressive Agents, Tricyclic; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D000547:Amantadine; D007099:Imipramine