Fetotoxic potentials of Globularia arabica and Globularia alypum (Globulariaceae) in rats.
Adult female Sprague-Dawley rats received by intragastric application, ethanolic extracts of Globularia arabica and Globularia alypum dried leaves. The effect of the extracts was monitored on fertility. The ingestion by female rats of 800 mg/kg of ethanolic extracts of G. arabica and G. alypum, from day 1 to day 6 of pregnancy, did not cause pregnancy failure. However, the ingestion of ethanolic extracts of G. alypum significantly reduced the number of viable fetuses. The number of resorptions was significantly increased in pregnant females administered ethanolic extracts of both G. arabica and G. alypum. The ingestion of 800 mg/kg of ethnologic extracts of G. arabica and G. alypum for 30 consecutive days by adult female rats had no significant effect on the occurrence of pregnancy. However, the ingestion of extracts of both species increased the number of resorptions and only G. alypum extract caused a significant reduction in the number of viable fetuses. These results indicate that ingestion of G. arabica and G. alypum could have some reproductive toxicity in female rats.
Elbetieha
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Department of Applied Biological Sciences, Faculty of Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. betieha@just.edu.jo
Oran
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SA
Alkofahi
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Darmani
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H
Raies
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D000019:Abortifacient Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D007441:Intubation, Gastrointestinal; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D000019:Abortifacient Agents; D010936:Plant Extracts