title: Control of the exercise hyperpnoea in humans: a modeling perspective.
abstract: Models of the exercise hyperpnoea have classically incorporated elements of proportional feedback (carotid and medullary chemosensory) and feedforward (central and/or peripheral neurogenic) control. However, the precise details of the control process remain unresolved, reflecting in part both technical and interpretational limitations inherent in isolating putative control mechanisms in the intact human, and also the challenges to linear control theory presented by multiple-input integration, especially with regard to the ventilatory and gas-exchange complexities encountered at work rates which engender a metabolic acidosis. While some combination of neurogenic, chemoreflex and circulatory-coupled processes are likely to contribute to the control, the system appears to evidence considerable redundancy. This, coupled with the lack of appreciable error signals in the mean levels of arterial blood gas tensions and pH over a wide range of work rates, has motivated the formulation of innovative control models that reflect not only spatial interactions but also temporal interactions (i.e. memory). The challenge is to discriminate between robust competing control models that: (a) integrate such processes within plausible physiological equivalents; and (b) account for both the dynamic and steady-state system response over a range of exercise intensities. Such models are not yet available.
authors.affiliation: Centre for Exercise Science and Medicine, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, G12 8QQ, Glasgow, UK. s.a.ward@bio.gla.ac.uk
authors.forename: S A
authors.initials: SA
authors.lastname: Ward
mesh_terms: D001775:Blood Circulation / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D003198:Computer Simulation; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D017933:Peripheral Nervous System / Q000502:physiology*; D015656:Respiratory Mechanics / Q000502:physiology