title: Interrater reliability levels of multiple clinical examiners in the evaluation of a schizophrenic patient: quality of life, level of functioning, and neuropsychological symptomatology.
abstract: Sir Ronald Fisher used a single-subject design to derive the concepts of appropriate research design, randomization, sensitivity, and tests of statistical significance. The seminal work of Broca demonstrated that valid and generalizable findings can and have emerged from studies of a single patient in neuropsychology. In order to assess the reliability and/or validity of any clinical phenomena that derive from single subject research, it becomes necessary to apply appropriate biostatistical methodology. The authors develop just such an approach and apply it successfully to the evaluation of the functioning, quality of life, and neuropsychological symptomatology of a single schizophrenic patient.
authors.affiliation: Child Study Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. dom.cicchetti@yale.edu
authors.forename: D V
authors.initials: DV
authors.lastname: Cicchetti
authors.forename: R
authors.initials: R
authors.lastname: Rosenheck
authors.forename: D
authors.initials: D
authors.lastname: Showalter
authors.forename: D
authors.initials: D
authors.lastname: Charney
authors.forename: J
authors.initials: J
authors.lastname: Cramer
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003024:Clozapine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D015588:Observer Variation; D010348:Patient Care Team; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine