Cs(2)CO(3)-promoted efficient carbonate and carbamate synthesis on solid phase.
[reaction: see text] Mild and efficient preparation of alkyl carbonates and carbamates on solid supports is described herein. Alcohols or amines were coupled with Merrifield's resin through a CO(2) linker in the presence of cesium carbonate and tetrabutylammonium iodide (TBAI).
Salvatore
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RN
Department of Chemistry (SCA 400), University of South Florida, and Drug Discovery Program, H. Lee Moffitt Cancer Center & Research Institute, 4202 East Fowler Avenue, Tampa, Florida 33620-5250, USA.
Flanders
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VL
Ha
D
D
Jung
K W
KW
D000438:Alcohols / Q000138:chemical synthesis; D000588:Amines / Q000138:chemical synthesis; D002219:Carbamates / Q000138:chemical synthesis*; D002254:Carbonates / Q000138:chemical synthesis*; D002586:Cesium / Q000737:chemistry
D000438:Alcohols; D000588:Amines; D002219:Carbamates; D002254:Carbonates; D002586:Cesium