Endothelin-converting enzyme-like 1 (ECEL1; 'XCE'): a putative metallopeptidase crucially involved in the nervous control of respiration.
Endothelin-converting enzyme-like 1 (ECEL1) is a putative zinc metalloprotease that was recently identified on the basis of its strong similarity to endothelin-converting enzyme 1. The physiological function of ECEL1 remains unknown so far; the failure to identify a substrate for ECEL1 could be related to the endoplasmic reticulum subcellular localization found by immunofluorescence in recombinant systems. However, clues to the function of ECEL1 were provided by the inactivation of its gene in mice, which resulted in neonatal lethality. The phenotype of homozygous ECEL1(-/-) mice, together with the very specific expression profile of its mRNA in the central nervous system, suggests that ECEL1 is crucially involved in the nervous control of respiration.
Valdenaire
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Axovan Ltd, Gewerbestrasse 16, 4123 Allschwil, Switzerland. olivier.valdenaire@actelion.com
Schweizer
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D000818:Animals; D015152:Blotting, Northern; D015153:Blotting, Western; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006720:Homozygote; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008856:Microscopy, Fluorescence; D005810:Multigene Family; D010641:Phenotype; D012333:RNA, Messenger / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry; D012119:Respiration; D015032:Zinc / Q000378:metabolism
D012333:RNA, Messenger; D011994:Recombinant Proteins; C120591:Ecel1 protein, mouse; D008666:Metalloendopeptidases; D015032:Zinc