Apoptosis: implications for inflammatory bowel disease.
Cells of the intestinal mucosa live in a harsh environment and therefore rely heavily on the highly regulated process of cell death, apoptosis, to maintain tissue integrity. Imbalance in the intracellular events that modulate apoptosis may contribute to the pathogenesis of inflammatory bowel disease.
Levine
A D
AD
Department of Medicine, Ireland Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106-4952, USA. adl4@po.cwru.edu
D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D002455:Cell Division; D006801:Humans; D007111:Immunity, Cellular; D015212:Inflammatory Bowel Diseases / Q000473:pathology*; D007413:Intestinal Mucosa / Q000166:cytology* / Q000201:enzymology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000494:pharmacology
D019253:Proto-Oncogene Proteins c-bcl-2; D020169:Caspases