title: Antiviral therapy for enteroviruses and rhinoviruses.
abstract: The picornaviruses are a diverse group of viral pathogens that together comprise the most common causes of infection of humans in the developed world. Within the picornavirus family are three well-known groups of human pathogens--the rhinoviruses, the enteroviruses (including polioviruses, coxsackieviruses and echoviruses) and the hepatoviruses (including hepatitis A virus). This article will focus on the rhinoviruses and enteroviruses, agents for which substantial effort has been expended, and recent successes reported, toward the development of safe and effective antiviral therapy.
authors.affiliation: University of Colorado School of Medicine, Department of Pediatrics, Denver, USA. harley.rotbart@UCHSC.edu
authors.forename: H A
authors.initials: HA
authors.lastname: Rotbart
mesh_terms: D000086042:3C Viral Proteases; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use; D002213:Capsid / Q000037:antagonists & inhibitors; D002460:Cell Line; D003139:Common Cold / Q000188:drug therapy; D003546:Cysteine Endopeptidases / Q000737:chemistry; D004352:Drug Resistance, Microbial; D004770:Enterovirus / Q000187:drug effects*; D004769:Enterovirus Infections / Q000188:drug therapy / Q000821:virology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007372:Interferons / Q000627:therapeutic use; D015394:Molecular Structure; D010091:Oximes; D010850:Picornaviridae Infections / Q000188:drug therapy* / Q000821:virology; D012229:Rhinovirus / Q000187:drug effects*; D013449:Sulfonamides; D014764:Viral Proteins
chemical_list: D000998:Antiviral Agents; D001562:Benzimidazoles; D016756:Immunoglobulins, Intravenous; D010091:Oximes; D013449:Sulfonamides; D014764:Viral Proteins; D007372:Interferons; D003546:Cysteine Endopeptidases; D000086042:3C Viral Proteases; C021595:viroxime