title: Chronic relapsing multifocal sensory-motor neuropathy with conduction block.
abstract: A 47 years old man had 13 episodes of relapsing and remitting sensory-motor neuropathy involving the upper limbs over the last 20 years. All but the last episode resolved spontaneously within 2 months. Neurophysiology revealed multifocal motor and sensory conduction block in the upper limbs with normal terminal latencies. CSF analysis was normal and anti-GM1 antibodies were not detected. There was a dramatic clinical improvement after intravenous immunoglobulin treatment. This case represents an unusual multifocal variant of chronic inflammatory demyelinating neuropathy.
authors.affiliation: Department of Clinical Neurophysiology and Epilepsies, St. Thomas' Hospital, London, UK.
authors.forename: I A
authors.initials: IA
authors.lastname: Sharoqi
authors.forename: D R
authors.initials: DR
authors.lastname: Sadoh
authors.forename: M
authors.initials: M
authors.lastname: Koutroumanidis
authors.forename: C P
authors.initials: CP
authors.lastname: Panayiotopoulos
mesh_terms: D000200:Action Potentials; D002908:Chronic Disease; D005121:Extremities / Q000294:innervation; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal / Q000503:physiopathology; D009431:Neural Conduction; D009475:Neurons, Afferent / Q000502:physiology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000503:physiopathology* / Q000628:therapy; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous