title: A flexible method for simulating cardiac conduction in three-dimensional complex geometries.
abstract: In this article we present a method for creating a membrane-based computer model capable of representing a three-dimensional irregular domain. The spatial discretization of our model is based on the Finite Volume Method. In combination with a robust meshmaking tool, our method may be used to simulate conduction in an arbitrarily shaped, complex region. In this way, conduction in specific subregions of cardiac anatomy may be examined. The capabilities of this methodology are demonstrated through 3 examples. The first shows the influence of abrupt changes in tissue geometry on conduction parameters. The second highlights the ability of the model to incorporate interior boundaries and altered membrane properties. The final example shows the inclusion of a full description of the fiber architecture in a portion of the canine left ventricle. Future applications will make use of the model's capabilities to conduct investigations in complex regions including the atria.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708-0281, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Harrild
authors.forename: R C
authors.initials: RC
authors.lastname: Penland
authors.forename: C S
authors.initials: CS
authors.lastname: Henriquez
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004285:Dogs; D006329:Heart Conduction System; D008433:Mathematics; D008955:Models, Cardiovascular