Transient detection of plasma HIV-1 RNA during postexposure prophylaxis.
Transient plasma human immunodeficiency virus (HIV) copies were detected by nucleic-acid sequence-based amplification during combination antiretroviral prophylaxis in a healthcare worker who reported a percutaneous injury from a stylet and who remained HIV-antibody-negative. An HIV-specific T-helper response, assessed by interleukin-2 production, was observed when tested at 13 months following the exposure.
Puro
V
V
IRCCS Lazzaro Spallanzani, Roma, Italy.
Calcagno
G
G
Anselmo
M
M
Benvenuto
G
G
Trabattoni
D
D
Clerici
M
M
Ippolito
G
G
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D005189:False Positive Reactions; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000517:prevention & control; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D016602:Needlestick Injuries; D021141:Nucleic Acid Amplification Techniques / Q000379:methods*; D016273:Occupational Exposure; D012367:RNA, Viral / Q000032:analysis*
D000998:Antiviral Agents; D012367:RNA, Viral