title: Polymorphonuclear leukocyte myeloperoxidase levels in patients with Behçet's disease.
abstract: Myeloperoxidase was measured in the plasma and in the supernatants of polymorphonuclear granulocyte cultures from patients with Behçet's disease. High levels were found in both plasma and supernatants from patients with active disease. The addition of pentoxifylline to granulocyte cultures determined a significant decrease of myeloperoxidase levels in active patients only. Hyperactive neutrophils are present during the course of Behçet's disease and may be considered of importance in the pathogenesis of the vascular lesions.
authors.affiliation: Cattedra di Allergologia e Immunologia Clinica, University of Palermo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Accardo-Palumbo
authors.forename: G
authors.initials: G
authors.lastname: Triolo
authors.forename: M C
authors.initials: MC
authors.lastname: Carbone
authors.forename: A
authors.initials: A
authors.lastname: Ferrante
authors.forename: F
authors.initials: F
authors.lastname: Ciccia
authors.forename: E
authors.initials: E
authors.lastname: Giardina
authors.forename: G
authors.initials: G
authors.lastname: Triolo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000276:immunology* / Q000378:metabolism*; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D010431:Pentoxifylline / Q000494:pharmacology; D009195:Peroxidase / Q000097:blood* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D009195:Peroxidase; D010431:Pentoxifylline