title: Structural and numerical aberrations of chromosome 22 in a case of follicular variant of papillary thyroid carcinoma revealed by conventional and molecular cytogenetics.
abstract: This study reports a case of papillary carcinoma with vesicular components showing multiclonal aberrations of chromosome 22 as revealed by RHG-banding cytogenetics and by fluorescence in situ hybridization (FISH; whole chromosome 22 and BCR-ABL-specific locus probes, multi-FISH). Four clones with chromosome 22 changes as the sole abnormality were seen. The main abnormal clone lacked the whole chromosome 22. A del(22)(q11) was observed in a second group of cells. The third clone had an idic(22). Finally, FISH revealed a fourth abnormal cell population with a der(17)t(?17;22). Some of these chromosome 22 alterations have been described in other solid tumors such as meningiomas and neurinomas, suggesting a common genetic pathway of tumor progression occurring in a multistep process. Chromosome 22 changes do not seem to be involved in pure papillary thyroid tumors and therefore could be related to the maintenance of a follicular-type histological pattern.
authors.affiliation: Laboratoire d'Histologie-Embryologie-Cytogénétique, Centre Jean-Perrin, Clermont-Ferrand, France.
authors.forename: B
authors.initials: B
authors.lastname: Perissel
authors.forename: I
authors.initials: I
authors.lastname: Coupier
authors.forename: M
authors.initials: M
authors.lastname: De Latour
authors.forename: N
authors.initials: N
authors.lastname: Cardot
authors.forename: F
authors.initials: F
authors.lastname: Penault-Llorca
authors.forename: J
authors.initials: J
authors.lastname: Jaffray
authors.forename: M
authors.initials: M
authors.lastname: Giollant
authors.forename: Y
authors.initials: Y
authors.lastname: Fonck
authors.forename: P
authors.initials: P
authors.lastname: Malet
mesh_terms: D000328:Adult; D018265:Carcinoma, Papillary, Follicular / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations / Q000235:genetics*; D020223:Chromosome Painting; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D004847:Epithelial Cells / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008677:Metaphase; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology; D014407:Tumor Cells, Cultured