title: Homograft mitral valve replacement: five years' results.
abstract: OBJECTIVE
  Results of mitral valve replacement with a mitral homograft were evaluated at 5 years to assess the suitability of the procedure.
  
  
  METHODS
  Thirty-seven patients (25 male subjects) aged 10 to 49 years (mean, 32 +/- 10 years) with rheumatic mitral valve disease underwent total (n = 35) or partial (n = 2) mitral valve replacement with a fresh antibiotic-preserved (n = 23) or cryopreserved (n = 14) mitral homograft. The predominant lesion was mitral stenosis (n = 30).
  
  
  RESULTS
  There were 5 early deaths. Operative survivors were followed up for 1 to 60 months (mean, 26.6 +/- 12 months). Among these, 21 patients had severe mitral regurgitation during the follow-up period; 3 died and 8 underwent reoperation. The homograft failure rate was not affected by preoperative physiologic lesion (stenosis vs regurgitation, P =.4), type of homograft (antibiotic-preserved vs cryopreserved homograft, P =.9), papillary muscle pretreatment (yes vs no, P =.9), or addition of posterior collar annuloplasty (yes vs no, P =.2). Among the remaining patients, 5 had moderate mitral regurgitation, 4 had either trivial or mild mitral regurgitation, and 2 were lost to follow-up. Study of the explanted mitral homografts (n = 8) revealed that disruption of one of the donor papillary muscles was responsible for early failures (n = 2), whereas cuspal and chordal degeneration was responsible for late failures (n = 6). Microscopically, the explanted valve lacked any viable cellular elements, and there was no evidence of immunologic injury to the homografts.
  
  
  CONCLUSIONS
  The mitral homograft did not fulfill our expectations as a suitable substitute for the diseased mitral valve.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, Department of Cardiology, and the Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: A S
authors.initials: AS
authors.lastname: Kumar
authors.forename: S K
authors.initials: SK
authors.lastname: Choudhary
authors.forename: A
authors.initials: A
authors.lastname: Mathur
authors.forename: A
authors.initials: A
authors.lastname: Saxena
authors.forename: R
authors.initials: R
authors.lastname: Roy
authors.forename: P
authors.initials: P
authors.lastname: Chopra
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology / Q000637:transplantation*; D008944:Mitral Valve Insufficiency / Q000209:etiology; D008946:Mitral Valve Stenosis / Q000601:surgery; D009926:Organ Preservation; D011183:Postoperative Complications; D012214:Rheumatic Heart Disease / Q000601:surgery; D014184:Transplantation, Homologous; D016896:Treatment Outcome