Inter- and intramolecular reductive coupling reactions: an approach to the phorbol skeleton.
[reaction: see text] An expeditious convergent route to the ABC-tricyclic core of the phorbol esters is described. The chemistry capitalizes upon both inter- and intramolecular reductive coupling processes promoted electrochemically and via the use of samarium diiodide.
Carroll
G L
GL
Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA.
Little
R D
RD
D002273:Carcinogens / Q000138:chemical synthesis; D010703:Phorbol Esters / Q000138:chemical synthesis*; D013237:Stereoisomerism
D002273:Carcinogens; D010703:Phorbol Esters