Lipid peroxidation in pregnancy with preeclampsia and diabetes.
We studied lipid peroxidation and vitamin E levels in 12 diabetic preeclamptic, 13 nondiabetic preeclamptic, 8 gestational diabetic, 25 normotensive pregnant women, and 25 healthy nonpregnant women. A significant increase in malonaldehyde (MDA) levels was observed in preeclamptic and diabetic preeclamptic women as compared to normotensive pregnant and healthy controls (p<0.001). An increase in MDA levels was observed in gestational diabetics, but the difference was not statistically significant. Likewise, a significant fall in vitamin E levels was noted in preeclamptic and diabetic preeclamptic groups as compared to controls (p<0.001). Gestational diabetics had a slight decrease in vitamin E levels relative to controls. These findings suggest that lipid peroxidation plays a role in the pathogenesis of preeclampsia.
Kharb
S
S
Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak, India.
D000328:Adult; D016640:Diabetes, Gestational / Q000097:blood / Q000150:complications; D005260:Female; D005316:Fetal Distress / Q000150:complications; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000150:complications; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000150:complications; D014810:Vitamin E / Q000097:blood
D014810:Vitamin E; D008315:Malondialdehyde