High-throughput screening: new technology for the 21st century.
New technologies in high-throughput screening have significantly increased throughput and reduced assay volumes. Key advances over the past few years include new fluorescence methods, detection platforms and liquid-handling technologies. Screening 100,000 samples per day in miniaturized assay volumes will soon become routine. Furthermore, new technologies are now being applied to information-rich cell-based assays, and this is beginning to remove one of the key bottlenecks downstream from primary screening.
Hertzberg
R P
RP
Molecular Screening Technologies, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA. robert_p_hertzberg@sbphrd.com
Pope
A J
AJ
D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000639:trends*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis*
D004364:Pharmaceutical Preparations