title: Increased susceptibility to malaria during the early postpartum period.
abstract: BACKGROUND
  Pregnancy is associated with increased susceptibility to malaria. It is generally agreed that this increased risk ends with delivery, but the possible persistence of increased susceptibility during the puerperium had not been investigated.
  
  
  METHODS
  From June 1, 1990, to December 31, 1998, we monitored exposure to malaria, parasitemia, and morbidity among the residents of a village in Senegal in which the rate of transmission of malaria was high. In this population we analyzed 71 pregnancies in 38 women from the year before conception and through one year after delivery.
  
  
  RESULTS
  Among the 38 women, there were 58 episodes of clinical Plasmodium falciparum malaria during 61,081 person-days of observation. The incidence of malaria was 20.2 episodes per 1000 person-months during the year preceding conception and 12.0 episodes per 1000 person-months during the period from 91 to 365 days after delivery. The incidence of episodes of malaria increased significantly during the second and third trimesters of pregnancy and reached a maximum of 75.1 episodes per 1000 person-months during the first 60 days after delivery. The adjusted relative risk of an episode of malaria was 4.1 (95 percent confidence interval, 1.8 to 9.5) during the first 60 days post partum, as compared with the year preceding pregnancy. The duration of fever during the episodes of malaria was longer and the prevalence and density of asymptomatic malarial parasitemia were significantly higher during pregnancy and the early postpartum period than during the other periods.
  
  
  CONCLUSIONS
  Among women who live in areas with high rates of transmission of malaria, the susceptibility to malaria is highest during the second and third trimesters of pregnancy and the early postpartum period.
authors.affiliation: Laboratoire de Paludologie, Institut de Recherche pour le Développement, Dakar, Senegal.
authors.forename: N
authors.initials: N
authors.lastname: Diagne
authors.forename: C
authors.initials: C
authors.lastname: Rogier
authors.forename: C S
authors.initials: CS
authors.lastname: Sokhna
authors.forename: A
authors.initials: A
authors.lastname: Tall
authors.forename: D
authors.initials: D
authors.lastname: Fontenille
authors.forename: C
authors.initials: C
authors.lastname: Roussilhon
authors.forename: A
authors.initials: A
authors.lastname: Spiegel
authors.forename: J F
authors.initials: JF
authors.lastname: Trape
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000453:epidemiology*; D009017:Morbidity; D018512:Parasitemia / Q000175:diagnosis / Q000453:epidemiology; D010963:Plasmodium falciparum / Q000302:isolation & purification; D016012:Poisson Distribution; D049590:Postpartum Period; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors; D012675:Senegal / Q000453:epidemiology