Pregnancy after treatment of secondary acute promyelocytic leukemia following Hodgkin's disease: a case report.
The authors report a case of therapy-related acute promyelocytic leukemia (t-APL), with typical cytogenetic translocation t(15;17), which appeared following chemotherapy (ABVD), and radiotherapy for Hodgkin's disease (IIB). After treatment with all-trans retinoic acid (Vesanoid(R) 45 mg/m2 daily) complete remission of t-APL was achieved. Then only one course of chemotherapy '3+7' (doxorubicin 45 mg/m2 1-3 d, cytosar 200 mg/m2 1-7d) was applied and the patient interrupted further treatment in July 1994. Four years later she had a normal pregnancy and delivered a healthy female infant in December 1998.
Elezović
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I
Institute of Haematology Clinical Center of Serbia, 11000 Belgrade, Yugoslavia. ivoelez@eunet.yu
Colović
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M
Tomin
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D
Bosković
D
D
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000139:chemically induced* / Q000188:drug therapy; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D014212:Tretinoin / Q000627:therapeutic use; D014747:Vinblastine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D001761:Bleomycin; D014212:Tretinoin; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin