[Modifying effect of nitrites on pulmonary blastogenesis and viral leukogenesis in mice: role of nitric oxide and dioxide].
The long-term effects of sodium nitrite (NaNO2) on carcinogenesis induced by urethane (total dose 1.0 mg/g body weight) in low-grade cancer F1 (C57BLxCBA) and high-grade A/Snell mice and on viral (Rausher leukemia virus) leukomogenesis in Balb/c mice. The murine intake of NaNO2 with water (50 mg/l) causes a statistically significant increase in the number of adenomas in the lung. Examining the mechanism of conversion of NO2- to NO led to the assumption that the free radical compounds NO and NO2 are involved in the potentiating action of NO2 on blastomogenesis. The use of the oxidant emoxypine (3-hydroxypyridine) confirmed the above. The role of NO and NO2 in the intracellular processes under the modifying effects of nitrites and nitrates on blastomogenesis is analyzed.
Il'nitskiĭ
A P
AP
Reutov
V P
VP
Ryzhova
N I
NI
Kolpakova
A S
AS
Deriagina
V P
VP
Nekrasova
E A
EA
Savluchinskaia
L A
LA
Travkin
A G
AG
D000236:Adenoma / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015197:Carcinogenicity Tests; D005260:Female; D009052:Leukemia Virus, Murine / Q000187:drug effects / Q000472:pathogenicity*; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D008168:Lung / Q000187:drug effects / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000494:pharmacology*; D009573:Nitrites / Q000494:pharmacology; D009585:Nitrogen Dioxide / Q000494:pharmacology*; D010083:Oxidants, Photochemical / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology
D000975:Antioxidants; D009573:Nitrites; D010083:Oxidants, Photochemical; D010847:Picolines; D009569:Nitric Oxide; D009585:Nitrogen Dioxide; C009820:6-methyl-2-ethyl-3-hydroxypyridine