title: Reversed-phase high-performance liquid chromatography combined with on-line UV diode array, FT infrared, and 1H nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry: application to a mixture of nonsteroidal antiinflammatory drugs.
abstract: A prototype multiply hyphenated system has been applied to the analysis of a mixture of nonsteroidal antiinflammatory drugs separated by reversed-phase HPLC. Characterization of the model NSAIDs was achieved via a combination of diode array UV, 1H NMR, FT-IR spectroscopy, and time-of-flight mass spectrometry. This combination of spectrometers allowed the collection of UV, 1H NMR, IR, and mass spectra together with atomic composition data enabling almost complete structural characterization to be performed.
authors.affiliation: LGC, The Health, Runcorn, Cheshire, UK.
authors.forename: D
authors.initials: D
authors.lastname: Louden
authors.forename: A
authors.initials: A
authors.lastname: Handley
authors.forename: S
authors.initials: S
authors.lastname: Taylor
authors.forename: E
authors.initials: E
authors.lastname: Lenz
authors.forename: S
authors.initials: S
authors.lastname: Miller
authors.forename: I D
authors.initials: ID
authors.lastname: Wilson
authors.forename: A
authors.initials: A
authors.lastname: Sage
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal