Synthesis and pharmacological characteristics of novel (Z)-3-arylidene-indolin-2(1H)-ones: preliminary results.
New amide derivatives of 1-(m-chlorophenyl)piperazine, the 5-HT2A antagonists 3-6, with moderate in vitro and in vivo activity were obtained by enlargement of the indolin-2(1H)-one core with 3-arylidene substituents.
Mokrosz
M J
MJ
Department of Medicinal Chemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Charakchieva-Minol
S
S
Kozioł
A
A
Kłodzińska
A
A
Chojnacka-Wójcik
E
E
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051379:Mice; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects*; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology
D007211:Indoles; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D007650:Ketanserin