Chemokine and cytokine cooperativity: eosinophil migration in the asthmatic response.
Eosinophils play a central role in the pathophysiology of allergic disease. The mechanisms that regulate eosinophil migration are complex; however, chemokines and cytokines produced in both the early and late phases of the asthmatic response appear to cooperate in eosinophil recruitment. In particular, there exists a unique synergy between eotaxin and IL-5. The role of chemokine/cytokine cooperativity has been investigated in the extracellular matrix, adhesion molecule/integrin interactions, receptor polarization and aggregation and the convergence and divergence of intracellular signalling pathways. Understanding the mechanisms whereby eosinophils migrate will allow the development of specific therapeutic strategies aimed at attenuating specific components of the allergic response.
Simson
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Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory.
Foster
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PS
D001249:Asthma / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects*; D054413:Chemokine CCL11; D018925:Chemokines / Q000494:pharmacology; D019742:Chemokines, CC; D016207:Cytokines / Q000494:pharmacology*; D004357:Drug Synergism; D004804:Eosinophils / Q000276:immunology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D015848:Interleukin-5 / Q000494:pharmacology; D019707:Receptors, Chemokine / Q000378:metabolism; D015398:Signal Transduction
C515456:CCL11 protein, human; D015815:Cell Adhesion Molecules; D054413:Chemokine CCL11; D018925:Chemokines; D019742:Chemokines, CC; D016207:Cytokines; D015848:Interleukin-5; D019707:Receptors, Chemokine