title: Detection of the brain response during a cognitive task using perfusion-based event-related functional MRI.
abstract: Event-related (ER) fMRI has evoked great interest due to the ability to depict the dynamic features of human brain function during various cognitive tasks. Thus far, all cognitive ER-fMRI studies have been based on blood oxygenation level-dependent (BOLD) contrast techniques. Compared with BOLD-based fMRI techniques, perfusion-based fMRI is able to localize the region of neuronal activity more accurately. This report demonstrates, for the first time, the detection of the brain response to a cognitive task using high temporal resolution perfusion-based ER-fMRI. An English verb generation task was used in this study. Results show that perfusion-based ER-fMRI accurately depicts the activation in Broca's area. Average changes in regional relative cerebral blood flow reached a maximum value of 30.7% at approximately 6.5 s after the start of stimulation and returned to 10% of the maximum value at approximately 12.8 s. Our results show that perfusion-based ER-fMRI is a useful tool for cognitive neuroscience studies, providing comparable temporal resolution and better localization of brain function than BOLD ER-fMRI.
authors.affiliation: Research Imaging Center, University of Texas Health Science Center, San Antonio 78284, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Yee
authors.forename: H L
authors.initials: HL
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Hou
authors.forename: Y
authors.initials: Y
authors.lastname: Pu
authors.forename: P T
authors.initials: PT
authors.lastname: Fox
authors.forename: J H
authors.initials: JH
authors.lastname: Gao
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology; D014705:Verbal Behavior / Q000502:physiology*