[Radiotherapy and coagulation system in women with cancer of the genital tract].
The question in the study was whether radiotherapy of women with neoplasma of genital tract leads to coagulation activation. The study group consisted of 51 women with cervical carcinoma (20 cases), endometrial carcinoma (22 cases) or ovarian neoplasma (9 cases). Fractionated dose of ionic energy were applied as follows: 200 cGy per day, 5 days a week, therapeutic dose of 4,500-5,000 cGy. Five coagulological tests were used. Hypercoagulability was found out prior to radiotherapy: statistically significantly elevated level of fibrinogen and higher thrombin-antithrombin III complexes (TAT) than in the control group. After radiotherapy the level of fibrinogen, prothrombin index, aPTT and TAT level did not undergo statistically significant changes.


CONCLUSIONS
Hypercoagulability in women with gynecological malignancy is an effect of the disease itself. Radiotherapy does not rise coagulation activation.
Miodońska
J
J
Katedry i Zakładu Propedeutyki Medycyny Akademii Medycznej w Bydgoszczy.
Ziółkowska
E
E
Uszyński
M
M
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000378:metabolism; D001778:Blood Coagulation Disorders; D002277:Carcinoma / Q000150:complications* / Q000532:radiotherapy*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005833:Genital Neoplasms, Female / Q000150:complications* / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D011516:Prothrombin / Q000378:metabolism; D011829:Radiation Dosage; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis
D000990:Antithrombin III; D011516:Prothrombin; D005340:Fibrinogen