title: [Single preoperative radiation exposure for stage II breast cancer].
abstract: The efficacy of different combinations of radiotherapy and mastectomy after Madden was compared in 411 patients with stage II breast tumors. The least likelihood of local reccurence (4.5 +/- 1.3%) was recorded after single exposure before mastectomy and with/without adjuvant irradiation of the regional lymphatics (group I); it appeared 1.5 times as high (7.0 +/- 2.1%) after mastectomy + postoperative irradiation (group II) while the highest frequency (14.8 +/- 5.4%) was registered after surgery alone (group III). Relapse-free 10-year survival was observed in 63.5 +/- 4.7 (group I), 77.4 +/- 4.6 (group II) and 46.2 +/- % (group III), respectively, the difference between group I and II being significant. Therefore, postoperative radiotherapy in conjunction with mastectomy (Madden) should be recommended for stage II breast carcinoma when the breast cannot be salvaged.
authors.affiliation: Russian Center for Roentgeno-Radiology Research, Ministry of Health of the RF, Moscow.
authors.forename: V P
authors.initials: VP
authors.lastname: Kharchenko
authors.forename: G A
authors.initials: GA
authors.lastname: Pan'shin
authors.forename: E V
authors.initials: EV
authors.lastname: Khmelevskiĭ
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Mel'nik
authors.forename: V K
authors.initials: VK
authors.lastname: Bozhenko
authors.forename: S V
authors.initials: SV
authors.lastname: Lapin
authors.forename: T I
authors.initials: TI
authors.lastname: Steniaeva
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000379:methods; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome