title: Association study of a functional serotonin transporter gene polymorphism with schizophrenia, psychopathology and clozapine response.
abstract: Serotonin is implicated in the pathogenesis of schizophrenia. Following serotonin release, the serotonin transporter (5-HTT) is the major determinant of serotonin inactivation. The present study tested the hypothesis that a biallelic polymorphism in the 5' regulatory region of the 5-HTT gene (5-HTTLPR) confers susceptibility to schizophrenia, association with the clinical manifestations of schizophrenia or clozapine response. 90 treatment-resistant schizophrenic patients were assessed using the Brief Psychiatric Rating Scale before and after clozapine treatment. The results demonstrated that the 5-HTTLPR variants did not play a major role in the susceptibility, clinical manifestations or clozapine response in schizophrenia.
authors.affiliation: Department of Psychiatry, Veterans General Hospital Taipei, Taipei, Taiwan.
authors.forename: S J
authors.initials: SJ
authors.lastname: Tsai
authors.forename: C J
authors.initials: CJ
authors.lastname: Hong
authors.forename: Y W
authors.initials: YW
authors.lastname: Yu
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
authors.forename: H L
authors.initials: HL
authors.lastname: Song
authors.forename: H C
authors.initials: HC
authors.lastname: Lai
authors.forename: K H
authors.initials: KH
authors.lastname: Yang
mesh_terms: D000328:Adult; D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D010054:Brief Psychiatric Rating Scale; D002352:Carrier Proteins / Q000235:genetics*; D003024:Clozapine / Q000627:therapeutic use*; D017931:DNA Primers / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics*; D012565:Schizophrenic Psychology
chemical_list: D014150:Antipsychotic Agents; D002352:Carrier Proteins; D017931:DNA Primers; D003024:Clozapine