The characterization of angiogenesis inhibitor from shark cartilage.
An angiogenesis inhibitor isolated from shark cartilage, SCF2, has been characterized. SCF2 was shown to have specific angiogenesis-inhibiting activity in endothelial cell culture assays. Results of structural and functional studies indicate that the inhibitor is not a typical protein. It is a heat-stable proteoglycan, which contains keratan sulfate units and peptide. Gel filtration chromatography shows that the molecular weight of the angiogenesis inhibitor is about 10 kd.
Liang
J H
JH
School of Natural Sciences, California State University, Fresno 93740, USA.
Wong
K P
KP
D020533:Angiogenesis Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002356:Cartilage / Q000737:chemistry*; D002417:Cattle; D002478:Cells, Cultured; D002850:Chromatography, Gel; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D008970:Molecular Weight; D011509:Proteoglycans / Q000302:isolation & purification / Q000494:pharmacology*; D012754:Sharks; D014407:Tumor Cells, Cultured
D020533:Angiogenesis Inhibitors; D011509:Proteoglycans