title: Progressive septal and palatal perforation secondary to intranasal cocaine abuse.
abstract: Septal perforation from intranasal cocaine abuse is well recognised. We present a case of progressive septal as well as palatal perforation. Progression from septal perforation to palatal perforation occurred after cessation of intranasal cocaine abuse. This patient had a weakly positive cytoplasmic antineutrophilic cytoplasmic antibody (C-ANCA) but no histologic evidence of Wegener's Granulomatosis. The differential diagnosis for septal and palatal perforation is reviewed. This case represents the fifth reported case of palatal perforation secondary to cocaine abuse in the literature, and the second associated with positive C-ANCA.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Hospital National University of Malaysia, Kuala Lumpur.
authors.forename: B S
authors.initials: BS
authors.lastname: Gendeh
authors.forename: B J
authors.initials: BJ
authors.lastname: Ferguson
authors.forename: J T
authors.initials: JT
authors.lastname: Johnson
authors.forename: S
authors.initials: S
authors.lastname: Kapadia
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D019970:Cocaine-Related Disorders / Q000150:complications*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000473:pathology; D009300:Nasal Septum; D009668:Nose Diseases / Q000139:chemically induced*; D010159:Palate / Q000473:pathology