Conformal intensity-modulated radiotherapy (IMRT) delivered by robotic linac--conformality versus efficiency of dose delivery.
Intensity-modulated radiotherapy (IMRT) may be delivered with a high-energy-photon linac mounted on a robotic gantry and executing a complex trajectory. In a previous paper an inverse-planning technique was developed for such an application. Here the work is extended to demonstrate the dependence of conformality on the size of the elemental pencil beam, on the complexity of the trajectory and on the sampling of azimuth and elevation of the collimated source. The improved conformality of complex trajectories is demonstrated and benchmarked relative to simpler trajectories, more representative of existing non-robotic IMRT techniques. Specifically, by choosing a very fine pencil beam, exquisitely conformal dose distributions have been obtained. Important sampling considerations have been determined. Expressions have been derived for the dosimetry and monitor-unit efficiency of robotic IMRT. Equivalent trajectories were computed for executing the complex robotic trajectories instead by using a conventional linac. The work benchmarks an ideal in IMRT against which more practical and more common techniques may be measured.
Webb
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Joint Department of Physics, Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, Surrey, UK.
D006801:Humans; D008297:Male; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D017785:Photons / Q000627:therapeutic use; D011467:Prostate / Q000528:radiation effects; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000295:instrumentation* / Q000379:methods*; D012007:Rectum / Q000528:radiation effects; D015203:Reproducibility of Results; D012371:Robotics; D001743:Urinary Bladder / Q000528:radiation effects