title: Actin and the smooth muscle regulatory proteins: a structural perspective.
abstract: The structural details of the smooth muscle acto-myosin interaction and its functional implications have been much discussed in recent years, however other, smooth muscle specific, actin-binding proteins have received much less attention. With increasing technical advances in structural biology a great deal of structural information is now coming to light, information that can provide useful insight into the mechanism of action for many important nonmotor actin-binding proteins. The purpose of the review is to instill the current knowledge on the structure, and interaction sites on F-actin, of the major, non-motor actin-binding proteins from smooth muscle, proposed to have a role in regulation. In the light of the recent structural studies the probable roles of the various actin-binding proteins will be discussed with particular reference to structure function relationships.
authors.affiliation: Imperial College of Science Technology and Medicine at The National Heart and Lung Institute, London, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Hodgkinson
mesh_terms: D000199:Actins / Q000737:chemistry* / Q000502:physiology; D000818:Animals; D002135:Calcium-Binding Proteins / Q000737:chemistry* / Q000502:physiology; D002148:Calmodulin-Binding Proteins / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D008840:Microfilament Proteins; D009130:Muscle, Smooth / Q000737:chemistry* / Q000502:physiology; D013329:Structure-Activity Relationship; D014335:Tropomyosin / Q000737:chemistry* / Q000502:physiology; D000096985:Calponins
chemical_list: D000199:Actins; D002135:Calcium-Binding Proteins; D002148:Calmodulin-Binding Proteins; D008840:Microfilament Proteins; D014335:Tropomyosin; D000096985:Calponins