Near full-length genome analysis of HIV type 1 CRF02.AG subtype C and CRF02.AG subtype G recombinants.
HIV-1 CRF02.AG strains are prevalent in west and west-central Africa, suggesting a longstanding presence of these subtype A/G recombinants in the global epidemic. Cocirculation of CRF02.AG strains with other group M subtypes may give rise to HIV-1 recombinants constituting a mosaic genome comprising fragments of three different subtypes. We report on the genetic analysis of the near-full-length genomes of such recombinants (VI1035 and VI1197) as well as CRF02.AG strains in Belgian individuals. VI1035 and VI1197 may be the result of successful "second-generation" recombinations of HIV-1 strains CRF02.AG with, respectively, subtype C (VI1035) and G (VI1197) strains in a dually infected individual.
Janssens
W
W
Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium. wjanssens@itg.be
Salminen
M O
MO
Laukkanen
T
T
Heyndrickx
L
L
van der Auwera
Colebunders
R
R
McCutchan
F E
FE
van der Groen
G
G
D000350:Africa, Central; D000354:Africa, Western; D001530:Belgium; D016679:Genome, Viral; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D010802:Phylogeny; D011995:Recombination, Genetic; D016415:Sequence Alignment