Screening of five drugs for efficacy against Babesia felis in experimentally infected cats.
The efficacy of 5 drugs was tested against experimental Babesia felis infection in domestic cats. Two of the drugs, rifampicin and a sulphadiazine-trimethoprim combination, appeared to have an anti-parasitic effect, but were inferior to primaquine. The other 3 drugs, buparvaquone, enrofloxacin and danofloxacin, had no significant anti-babesial effect.
Penzhorn
B L
BL
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa. bpenzhorn@op.up.ac.za
Lewis
B D
BD
López-Rebollar
L M
LM
Swan
G E
GE
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001404:Babesiosis / Q000188:drug therapy*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004338:Drug Combinations; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D006400:Hematocrit / Q000662:veterinary; D009285:Naphthoquinones / Q000627:therapeutic use; D018512:Parasitemia / Q000188:drug therapy*; D011319:Primaquine / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use
D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D004338:Drug Combinations; D024841:Fluoroquinolones; D009285:Naphthoquinones; D015363:Quinolones; C046326:buparvaquone; D013411:Sulfadiazine; C068581:danofloxacin; D000077422:Enrofloxacin; D014295:Trimethoprim; D011319:Primaquine; D012293:Rifampin