Demonstration and diagnostic significance of pro-gastrin-releasing peptide in medullary thyroid carcinoma.
The expression of pro-gastrin-releasing peptide (proGRP) in medullary thyroid carcinoma (MTC) and other histological types of thyroid carcinoma was studied by an immunohistochemical technique, using polyclonal anti-proGRP antiserum. Immunoreactivity for proGRP was detected exclusively in MTC (n = 7); other histological types (n = 12) were all negative for proGRP. In addition, serum proGRP levels were elevated in patients with primary or recurrent MTC (n = 3), and they changed in parallel with serum calcitonin (CT), and carcinoembryonic antigen (CEA). These results show that proGRP, which is considered to be a specific marker for small-cell lung carcinoma, may be also a potential tumor marker for MTC, in addition to CT and CEA.
Inaji
H
H
Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Komoike
Y
Y
Motomura
K
K
Higashiyama
M
M
Ohtsuru
M
M
Funai
H
H
Kasugai
T
T
Koyama
H
H
D014408:Biomarkers, Tumor / Q000097:blood*; D018276:Carcinoma, Medullary / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000096:biosynthesis / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011379:Prognosis; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D010446:Peptide Fragments; D010455:Peptides; D011994:Recombinant Proteins; C087079:pro-gastrin-releasing peptide (31-98)