title: Coronary artery plaque disruption as cause of acute myocardial infarction during cesarean section with spinal anesthesia.
abstract: A 31-year-old parturient delivered twins at 35 weeks' gestation by cesarean section with spinal anesthesia. Following anesthesia induction, hypotension and bradycardia occurred, and were immediately treated with theodrenaline plus cafedrin (Akrinor) and atropine. Blood pressure and heart rate increased to 180/100 mmHg and 140 beats per minute, respectively. Several minutes later, the patient developed a myocardial infarction (MI) that she survived after intensive care treatment without sequelae. Although the coronary angiography showed normal coronary vessels, an intravascular ultrasound study demonstrated an atheroma in the left main coronary artery with ruptured fibrous cap. Laboratory screening for risk factors of coronary artery disease (CAD) showed hypercholesterinemia, increased factor VII activity, and hyperfibrogenemia. Angiographically normal coronary vessels are frequently found in pregnant patients who suffered MI. In these patients, coronary spasms have been discussed as the major mechanism of disease. Our case demonstrates that a significant CAD may be present despite angiographically normal findings. Plaque rupture was triggered by hypertension and led to MI as the first symptom of disease. On the basis of these findings, we believe that MI during pregnancy is more often caused by plaque rupture than may be expected, according to the current literature.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Evangelisches Krankenhaus Oberhausen, Germany. Peter.Kulka@ruhr-uni-bochum.de
authors.forename: P J
authors.initials: PJ
authors.lastname: Kulka
authors.forename: C
authors.initials: C
authors.lastname: Scheu
authors.forename: M
authors.initials: M
authors.lastname: Tryba
authors.forename: R
authors.initials: R
authors.lastname: Oberheiden
authors.forename: M
authors.initials: M
authors.lastname: Zenz
mesh_terms: D000208:Acute Disease; D000328:Adult; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D002585:Cesarean Section; D003327:Coronary Disease / Q000150:complications* / Q000000981:diagnostic imaging; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000209:etiology*; D011247:Pregnancy; D014463:Ultrasonography