title: Temporal relation between acoustic and force responses at the adductor pollicis during nondepolarizing neuromuscular block.
abstract: BACKGROUND
  Contracting muscle emits sounds. The purpose of this study was to compare the time course of muscular paralysis at the adductor pollicis muscle (AP) with use of acoustic myography and mechanomyography.
  
  
  METHODS
  Thirteen elective surgery patients, American Society of Anesthesiologists physical status I, received rocuronium (0.6 mg/kg intravenously) as a bolus dose during general anesthesia. Force of AP was measured with use of a strain gauge, and sounds were recorded simultaneously with use of a small condenser microphone fixed on the palmar surface of the hand over the AP. Supramaximal stimulation was applied to the ulnar nerve at 0.1 Hz for 45-60 min. In seven patients, the response to train-of-four stimulation was also recorded during recovery.
  
  
  RESULTS
  Force and sounds both were equally sensitive in measuring maximum block. The relation between sound and force was curvilinear, with good agreement near 0 and 100% and acoustic response exceeding mechanical response at intermediate levels of block. The acoustic signal had a slower onset and a faster recovery than the force response. The fade response of sound to train-of-four stimulation also recovered faster than that of force.
  
  
  CONCLUSIONS
  Acoustic myography is an alternative method to monitor muscular paralysis that is easy to set up and applicable to most superficial muscles. However, the time course of relaxation at AP using acoustic myography differs from the time course of force relaxation. Therefore, these two methods are not equivalent when applied to AP.
authors.affiliation: Research Center and Department of Anesthesiology, Hotel-Dieu, Montreal University Hospital Center, Montréal, Québec, Canada. francois.bellemare@umontreal.ca
authors.forename: F
authors.initials: F
authors.lastname: Bellemare
authors.forename: J
authors.initials: J
authors.lastname: Couture
authors.forename: F
authors.initials: F
authors.lastname: Donati
authors.forename: B
authors.initials: B
authors.lastname: Plaud
mesh_terms: D000328:Adult; D000732:Androstanols / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects* / Q000502:physiology; D009213:Myography; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D000077123:Rocuronium; D013997:Time Factors
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium