Homocysteine: a history in progress.
This paper shows that the linkage between basic science and clinical research has characterized the field of sulfur amino acid metabolism since 1810, when Wollaston isolated cystine from a human bladder stone. The nature and consequences of this relationship are discussed.
Finkelstein
J D
JD
Veterans Affairs Medical Center, George Washington University, DC 20422, USA.
D049672:History, 19th Century; D049673:History, 20th Century; D006710:Homocysteine / Q000032:analysis / Q000266:history* / Q000378:metabolism; D006712:Homocystinuria / Q000201:enzymology / Q000266:history; D006801:Humans; D007328:Insulin / Q000737:chemistry / Q000266:history; D008715:Methionine / Q000032:analysis / Q000737:chemistry / Q000266:history; D009436:Neural Tube Defects / Q000266:history; D009656:North America; D012106:Research / Q000266:history*; D012436:S-Adenosylmethionine / Q000032:analysis / Q000737:chemistry / Q000266:history; D000078329:Workforce
D007328:Insulin; D006710:Homocysteine; D012436:S-Adenosylmethionine; D008715:Methionine