title: [The effect of antihypertensive therapy on insulin resistance].
abstract: Insulin resistance is one of the main causes of diabetes mellitus type 2. This primary, genetically determined, by external environmental factors enhanced, reduced insulin effectiveness in target tissues (liver, muscle, adipose tissue) associated with compensatory hyperinsulinaemia is manifested by a prohypertensive effect. Secondary insulin resistance causes deterioration of diabetes compensation regardless of its type. It may have a number of causes and after their elimination it is fully reversible. Secondary insulin resistance can be influenced also by drugs. This fact must be born in mind when selecting antihypertensive treatment in diabetics.
authors.affiliation: II. interní klinika FN U sv. Anny Brno.
authors.forename: J
authors.initials: J
authors.lastname: Olsovský
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D007333:Insulin Resistance
chemical_list: D000959:Antihypertensive Agents