Creutzfeldt-Jakob disease in health professionals in Slovakia.
Creutzfeldt-Jakob disease (CJD) is the most important human transmissible spongiform encephalopathy (prion disease), recognised in sporadic, genetic but also iatrogenic forms. The identification of 8 health care workers in a group of 114 definitive CJD patients in Slovakia suggested the possibility of professionally acquired CJD and induced the investigation of potential endo- and exogenous risk factors. In CJD-affected health professionals special attention was paid to a detailed occupational history, including a possible professional contact with CJD patient and to the findings characteristic for iatrogenic CJD: early cerebellar symptomatology, long duration of the disease, absence of typical EEG finding and homozygosity of PRNP gene at codon 129. Analysis of epidemiological, clinical and molecular biological data in investigated group of CJD-affected health professionals gave no evidence of an occupational risk for CJD.
Mitrová
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Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.
Belay
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D000488:Allied Health Personnel; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007049:Iatrogenic Disease; D017758:Infectious Disease Transmission, Patient-to-Professional; D009784:Occupational Diseases / Q000453:epidemiology*; D018570:Risk Assessment; D018154:Slovakia / Q000453:epidemiology