title: Synthesis and alpha(1)-antagonist activity of derivatives of 4-chloro-5-[4-[2-(2-methoxyphenoxy)-ethyl]-1-piperazinyl]-3(2H)-pyrid azinone.
abstract: The synthesis and evaluation of the biological activity of new 4-chloro-5-¿4-[2-(2-methoxyphenoxy)-ethyl]-1-piperazinyl¿-3(2H)-pyrid azinone derivatives are reported. The blocking activity of these compounds was determined on the pre- and postsynaptic alpha-adrenoceptors of isolated rat vas deferens.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Università di Perugia, Via del Liceo 1, 06123, Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Strappaghetti
authors.forename: R
authors.initials: R
authors.lastname: Barbaro
authors.forename: G
authors.initials: G
authors.lastname: Marucci
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D014649:Vas Deferens / Q000187:drug effects
chemical_list: C414351:4-chloro-5-(4-(2-(2-methoxyphenoxy)ethyl)-1-piperazinyl)-3(2H)-pyridazinone; D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D010879:Piperazines; D011724:Pyridazines