title: Postablative risk of endometrial carcinoma in New Zealand white rabbits given high-dose estrogen.
abstract: OBJECTIVE
  To follow a population at high risk for endometrial carcinoma after endometrial ablation, to determine if ablation alters the incidence or detection of endometrial pathology.
  
  
  METHODS
  The animal model included 33 New Zealand white rabbits. Of this cohort, 17 underwent surgical ablation of the endometrium via laparotomy, while 16 served as controls. Vaginal bleeding was assessed with monthly cotton swab examinations as well as daily observation of the subjects. All animals received unopposed estrogen for 18 months prior to necropsy.
  
  
  RESULTS
  No animal in either arm of the study demonstrated vaginal bleeding. Two rabbits from the ablation group and three controls showed histologic evidence of atypical endometrial hyperplasia or adenocarcinoma (P > .20). One additional animal from each group had hyperplasia without atypia.
  
  
  CONCLUSIONS
  This animal model suggests that endometrial ablation does not decrease the risk of endometrial carcinoma in patients at high risk of developing endometrial pathology. Detection of hyperplasia or carcinoma in such a population may prove difficult due to the absence of traditional signs of endometrial abnormalities.
authors.affiliation: Department of Obstetrics and Gynecology, University of Missouri-Columbia 65212, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Horowitz
authors.forename: S
authors.initials: S
authors.lastname: Christensen
authors.forename: C
authors.initials: C
authors.lastname: Kennebeck
authors.forename: R L
authors.initials: RL
authors.lastname: Graham
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000453:epidemiology / Q000662:veterinary; D000818:Animals; D017115:Catheter Ablation; D004714:Endometrial Hyperplasia; D016889:Endometrial Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000662:veterinary; D004717:Endometrium / Q000473:pathology / Q000601:surgery*; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D015994:Incidence; D011817:Rabbits; D012307:Risk Factors; D014592:Uterine Hemorrhage
chemical_list: D004958:Estradiol