title: Use of saliva specimens for monitoring indinavir therapy in human immunodeficiency virus-infected patients.
abstract: Indinavir concentrations were determined in plasma and saliva over a random period of 4 h. On average, levels in saliva were 70% +/- 38% of the corresponding levels in plasma. These findings suggest that saliva might serve as an appropriate specimen for monitoring of plasma indinavir levels in patients treated with indinavir.
authors.affiliation: Department of Infectious Diseases and Immunology, Federal Republic of Germany. uwe.wintergerst@KK-i.med.uni-muenchen.de
authors.forename: U
authors.initials: U
authors.lastname: Wintergerst
authors.forename: M
authors.initials: M
authors.lastname: Kurowski
authors.forename: B
authors.initials: B
authors.lastname: Rolinski
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: E
authors.initials: E
authors.lastname: Wolf
authors.forename: H
authors.initials: H
authors.lastname: Jaeger
authors.forename: B H
authors.initials: BH
authors.lastname: Belohradsky
mesh_terms: D000328:Adult; D016903:Drug Monitoring; D005240:Feasibility Studies; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D017320:HIV Protease Inhibitors / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D019469:Indinavir / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D008297:Male; D012463:Saliva / Q000378:metabolism*
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir