Five exon 1 variants of mu opioid receptor and vulnerability to alcohol dependence.
The human mu opioid receptor (hMOR) gene is a prime candidate gene responsible for addictive disorders. The present association study tested the hypothesis that hMOR exon 1 variants elicit susceptibility to alcohol dependence. We have analyzed five nucleotide changes in exon 1 of the hMOR gene. Three of them are in the 5'untranslated region of exon 1 at positions -172G/T,-111C/T and -3 8C/A, the remaining two variants cause amino acid substitutions: +17C/T (Ala6Val) and +118A/G (Asn40Asp). Our population-based association study included 327 German alcohol-dependent subjects and 340 ethnically matched controls. The lack of an allelic association suggests that the analyzed hMOR exon 1 variants do not contribute a common and substantial effect to the genetically determined vulnerability of alcohol dependence.
Gscheidel
N
N
Genome Research, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany.
Sander
T
T
Wendel
B
B
Heere
P
P
Schmidt
L G
LG
Rommelspacher
H
H
Hoehe
M R
MR
Samochowiec
J
J
D020121:5' Untranslated Regions / Q000235:genetics; D000437:Alcoholism / Q000235:genetics*; D000483:Alleles; D019943:Amino Acid Substitution; D004247:DNA / Q000235:genetics; D005091:Exons / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D017450:Receptors, Opioid, mu / Q000235:genetics*
D020121:5' Untranslated Regions; D017450:Receptors, Opioid, mu; D004247:DNA