Chemical investigation of Mycale mytilorum and a study on toxicity and antidiabetic activity of 5-octadecylpyrrole-2-carboxaldehyde.
Chemical investigation of Mycale mytilorum afforded four new and two known compounds, of which 5-octadecylpyrrole-2-carboxaldehyde (1) and (6'Z)-5-(6'-heneicosenyl) pyrrole-2-carboxaldehyde (2, congeners of alkylpyrrole carboxadehyde), (2S,3R,4E)-1,3-dihydroxy-2-[(heneicosanoyl) amino]-4-heneicosene (5, sphingolipid) and 2-methyl-3-(4,5,7-trihydroxy-8-hydroxy-methyltetrahydro-6H-4-py ranyl)-2-propenoic acid (6, tetrahydropyran derivative) are new, and batylalcohol (3) and p-hydroxyphenylacetic acid (4) are known. The toxicity and antidiabetic activity of 5-octadecylpyrrole-2-carboxaldehyde were evaluated for the first time. Also, compounds 1, 2, 5 and 6 were studied for the antibacterial, antifungal and antiviral activity.
Reddy
G B
GB
Trushna Exports Private Limited, Gammon Colony, Karnataka, India. gbalreddy@hotmail.com
Dhananjaya
N
N
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D002522:Chlorocebus aethiops; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D051379:Mice; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D018139:Simplexvirus / Q000187:drug effects; D014709:Vero Cells
C417189:5-octadecylpyrrole-2-carboxaldehyde; D000998:Antiviral Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D011758:Pyrroles