title: Synthesis of 9-(2-deoxy-beta-D-ribofuranosyl)purine-2-thione.
abstract: A synthesis of 9-(2-deoxy-beta-D-ribofuranosyl)purine-2-thione was performed by desulfurization of 2'-deoxy-6-thioguanine to give 2-amino-9-(2-deoxy-beta-D-ribofuranosyl)purine, diazotization with chloride replacement to give 2-chloro-9-(2-deoxy-beta-D-ribofuranosyl)purine, and the replacement of chloride with sulfur using thiolacetic acid and deacetylation.
authors.affiliation: Biology Department, Temple University, Philadelphia, PA 19122, USA.
authors.forename: H P
authors.initials: HP
authors.lastname: Rappaport
mesh_terms: D002851:Chromatography, High Pressure Liquid; D013058:Mass Spectrometry; D009705:Nucleosides / Q000138:chemical synthesis*; D011687:Purines / Q000138:chemical synthesis*; D013053:Spectrophotometry; D013871:Thiones / Q000138:chemical synthesis*
chemical_list: C417423:9-(2-deoxy-ribofuranosyl)purine-2-thione; D009705:Nucleosides; D011687:Purines; D013871:Thiones