Molecular mechanisms of invasion by cancer cells, leukocytes and microorganisms.
Invasion is a phenotype common to cancer cells, leukocytes, parasites, bacteria and viruses, involving cell-cell adhesion, cell-matrix adhesion, proteolysis and motility. These activities are regulated by the cross talk between invaders and host. We discuss the invasion-related molecular interactions of E-cadherin, integrins, matrix metalloproteinases and the chemokine receptor RANTES.
Lauwaet
T
T
Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, Belgium.
Oliveira
M J
MJ
Mareel
M
M
Leroy
A
A
D000818:Animals; D018407:Bacterial Physiological Phenomena; D015820:Cadherins / Q000378:metabolism; D002450:Cell Communication; D018946:Chemokine CCL5 / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D007962:Leukocytes / Q000502:physiology*; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D010271:Parasites / Q000502:physiology*; D014407:Tumor Cells, Cultured; D018406:Virus Physiological Phenomena
D015820:Cadherins; D018946:Chemokine CCL5; D016023:Integrins; D020782:Matrix Metalloproteinases