title: Acute painful diabetic neuropathy: two patients with recent insulin-dependent diabetes mellitus.
abstract: Two young men developed an acute painful peripheral neuropathy a few weeks after being diagnosed to suffer from an insulin-dependent diabetes mellitus. In both cases, peripheral nerve biopsy exhibited a few features of acute axonal degeneration. Additionally, in the first case there was a lymphocytic infiltrate around an endoneurial capillary, and in the second case there were several mast cells in the endoneurium of every fascicle examined. A few months later, the acute pain had disappeared in both cases. Only a few cases of acute painful diabetic neuropathy have been reported so far. A vascular origin seems unlikely and metabolic disorders are probably due to a contemporary severe weight loss. An auto-immune mechanism is an alternative explanation.
authors.affiliation: Neuropathology and Anatomic Pathology Laboratory, Victor Segalen University, Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Vital
authors.forename: A
authors.initials: A
authors.lastname: Vital
authors.forename: M
authors.initials: M
authors.lastname: Dupon
authors.forename: H
authors.initials: H
authors.lastname: Gin
authors.forename: M
authors.initials: M
authors.lastname: Rouanet-Larriviere
authors.forename: J Y
authors.initials: JY
authors.lastname: Lacut
mesh_terms: D000208:Acute Disease; D000328:Adult; D001369:Axons / Q000473:pathology; D002196:Capillaries / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009410:Nerve Degeneration / Q000473:pathology; D010146:Pain / Q000503:physiopathology; D010525:Peripheral Nerves / Q000098:blood supply / Q000473:pathology