title: Re-evaluation of normative electronystagmography data in healthy ageing.
abstract: Previous work by our group questions the validity of existing electronystagmography (ENG) reference ranges in the elderly. We aim to establish valid reference ranges for ENG in people over 65 on the Nicolet Nystar Plus system. Ninety-six healthy asymptomatic subjects over 65 underwent ENG, including spontaneous and positional nystagmus, saccades, smooth pursuit, optokinetic nystagmus and bithermal calorics; 95% reference ranges with confidence intervals were calculated. The newly determined reference ranges were far wider than those provided by the ENG equipment manufacturer for eight out of 11 parameters (all P < 0.001). Vestibular function is known to deteriorate and become more variable with age. The failure to reflect this change in currently used reference ranges may have contributed to the high rates of vestibular disease reported in some series of dizzy elderly patients. Clinical interpretation of ENG depends on valid reference ranges.
authors.affiliation: Department of Otolaryngology, Freeman Hospital, Newcastle, Department of Audiology and Department of Medicine, University of Edinburgh, UK. dh@pobox.com
authors.forename: D
authors.initials: D
authors.lastname: Hajioff
authors.forename: R M
authors.initials: RM
authors.lastname: Barr-Hamilton
authors.forename: N R
authors.initials: NR
authors.lastname: Colledge
authors.forename: S J
authors.initials: SJ
authors.lastname: Lewis
authors.forename: J A
authors.initials: JA
authors.lastname: Wilson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004584:Electronystagmography / Q000295:instrumentation; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values