title: [Effectiveness of dietary non-starch polysaccharides in experimental toxic hepatitis].
abstract: The efficiency of some polysaccharides was investigated in mice with an experimental toxic hepatitis. Hepatitis was induced by the oral administration of 10% solution CCl4 in olive oil at a dosage of 3 ml/kg body weight every day during 7 days. After that tested substances were administrated every day 30-40 min before a feeding at a dosage of 150 mg/kg body weight during 14-21 days. Results showed that a calcium alginate, two low-methoxyl pectins (one with the degree of esterification about 50% and other with the degree of esterification less 5%), fucoidan, and chitozan, but not lambda-carrageenan and kappa-carrageenan, have beneficial affects on liver total lipid, glycogen, malondialdehyde, and diene conjugates as well as on blood total lipid and alanine aminotransferase activity in animals with experimental toxic hepatitis.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Khotimchenko
authors.forename: E I
authors.initials: EI
authors.lastname: Khasina
authors.forename: V V
authors.initials: VV
authors.lastname: Kovalev
authors.forename: O I
authors.initials: OI
authors.lastname: Shevtsova
authors.forename: S V
authors.initials: SV
authors.lastname: Shestakova
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications*; D002351:Carrageenan / Q000008:administration & dosage / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000178:diet therapy* / Q000209:etiology / Q000378:metabolism; D002686:Chitin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D048271:Chitosan; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000494:pharmacology; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000178:diet therapy* / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D004040:Dietary Carbohydrates; D008055:Lipids; D011134:Polysaccharides; D002686:Chitin; D002351:Carrageenan; D048271:Chitosan; C007789:fucoidan; D000410:Alanine Transaminase