title: Synthesis of 3'-O2-(azaheterocycle)-thymidines.
abstract: The synthesis of 3'-O2-(azaheterocycle)-thymidines is presented from 1-thia-3-aza- 1,3-butadiene precursors (N-thioacylamidines). A variety of heterocycles is accessible using the dienic, the electrophilic or the nucleophilic reactivity of these thia-azabutadiene systems. 3'-O2-(azaheterocycle)-thymidine analogues are regarded as potential substrates to interfere with the DNA-polymerization process.
authors.affiliation: Laboratoire de Synthèse Organique associé au CNRS, UMR 6513, Faculté des Sciences et des Techniques, Nantes, France.
authors.forename: G
authors.initials: G
authors.lastname: Prestat
authors.forename: D
authors.initials: D
authors.lastname: Dubreuil
authors.forename: A
authors.initials: A
authors.lastname: Adjou
authors.forename: J P
authors.initials: JP
authors.lastname: Pradère
authors.forename: J
authors.initials: J
authors.lastname: Lebreton
authors.forename: M
authors.initials: M
authors.lastname: Evers
authors.forename: Y
authors.initials: Y
authors.lastname: Henin
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D003601:Cytotoxicity Tests, Immunologic; D015497:HIV-1 / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D012194:RNA-Directed DNA Polymerase / Q000009:adverse effects; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D001372:Aza Compounds; D012194:RNA-Directed DNA Polymerase; D013936:Thymidine