Functional MR imaging activation after finger tapping has a shorter duration in the basal ganglia than in the sensorimotor cortex.
OBJECTIVE
Repetitive motor tasks that produce sustained neuronal activity in the sensorimotor cortex produce transient neuronal activity in subcortical regions. We tested the hypothesis that a reference function modeling a transient hemodynamic response would more reliably detect activation in the basal ganglia than would a conventional reference function, which models a sustained hemodynamic response.


METHODS
Functional MR imaging data were acquired in eight subjects performing an alternating-hand finger-tapping task. Postprocessing was performed by cross-correlation to two types of reference functions: one that models a sustained hemodynamic response to finger tapping and one that models an initial transient hemodynamic response. Activation in the sensorimotor cortex, supplementary motor area, cerebellum, thalamus, and corpus striatum was tabulated for each reference function.


RESULTS
With the conventional boxcar reference function, activation was detected in the sensorimotor cortex, supplementary motor area, and cerebellum, but intermittently in the corpus striatum in all subjects. With the reference function for a transient response, activation in the corpus striatum was not detected in all subjects.


CONCLUSIONS
In the corpus striatum, activation is detected more frequently with a reference function that models a transient response. Activated cortical and subcortical regions can be mapped with an alternating-hand finger-tapping paradigm and a combination of reference functions.
Moritz
C H
CH
Department of Radiology, University of Wisconsin, Madison, USA.
Meyerand
M E
ME
Cordes
D
D
Haughton
V M
VM
D000328:Adult; D001479:Basal Ganglia / Q000502:physiology*; D001931:Brain Mapping; D002531:Cerebellum / Q000502:physiology; D003342:Corpus Striatum / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*