title: Artefacts in multi-echo T2 imaging for high-precision gel dosimetry: II. Analysis of B1-field inhomogeneity.
abstract: In BANG gel dosimetry, the spin-spin relaxation rate, R2 = 1/T2, is related to radiation dose that has been delivered to a gel phantom. R2 is calculated by fitting the pixel intensities of a set of differently T2-weighted base images. The accuracy that is aimed for in this quantitative MR application is about 5% relative to the maximum dose. In a conventional imaging MR scanner, however, several imaging artefacts may perturb the final dose map. These deviations manifest themselves as either a deformation of the dose map or an inaccuracy of the dose pixel value. Inaccuracies in the dose maps are caused by both spatial and temporal deviations in signal intensities during scanning. This study deals with B1-field inhomogeneities as a source of dose inaccuracy. First, the influence of B1-field inhomogeneities on slice profiles is investigated using a thin-slice phantom. Secondly, a FLASH sequence is used to map the B1-field by assessing the effective flip angle in each voxel of a homogeneous phantom. In addition, both experiments and computer simulations revealed the effects of B1 field inhomogeneities on the measured R2. This work offers a method to correct R2 maps for B1 -field inhomogeneities.
authors.affiliation: Radiotherapy and Nuclear Medicine, University Hospital of Gent, Belgium. yves.dedeene@rug.ac.be
authors.forename: Y
authors.initials: Y
authors.lastname: De Deenet
authors.forename: C
authors.initials: C
authors.lastname: De Wagter
authors.forename: W
authors.initials: W
authors.lastname: De Neve
authors.forename: E
authors.initials: E
authors.lastname: Achten
mesh_terms: D020106:Acrylamide; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D017352:Echo-Planar Imaging / Q000295:instrumentation* / Q000379:methods*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods*; D005780:Gelatin; D007091:Image Processing, Computer-Assisted; D015233:Models, Statistical; D008962:Models, Theoretical; D009584:Nitrogen; D019047:Phantoms, Imaging; D019904:Polymethyl Methacrylate; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D020106:Acrylamide; D005780:Gelatin; D019904:Polymethyl Methacrylate; D009584:Nitrogen