Re-mobilization of peripheral blood progenitor cells within a short time interval fails to achieve effective progenitor cell yields.
We report the case of a healthy donor who was mobilized for the purpose of performing an unrelated donor transplantation with subcutaneous injections of rhG-CSF. Because of accidental loss of progenitors, 3 days after completing the first collection, the donor was mobilized again with rhG-CSF, and progenitors were collected. While a similar increase in the pre-apheresis leukocyte count was observed in both procedures, fewer mononuclear cells were mobilized during the second rhG-CSF course, resulting in a poor CD34+ yield. These data suggest that an 8-day interval between commencement of rhG-CSF mobilizations is insufficient to predict an efficient collection of hematopoietic progenitors to ensure engraftment after bone marrow transplantation.
Vallejo
C
C
Unit of Hematology and Clinical Oncology, University General Hospital and School of Medicine, Murcia, Spain.
Lozano
M L
ML
Ortuño
F
F
Moraleda
J M
JM
Vicente
V
V
D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007937:Leukapheresis; D008875:Middle Aged; D013997:Time Factors; D014019:Tissue Donors
D016179:Granulocyte Colony-Stimulating Factor