Influence of experimental chronic high-pressure glaucoma on age-related macular degeneration in rhesus monkeys.
OBJECTIVE
To assess prospectively whether development of age-related macular degeneration is influenced by experimentally induced chronic high-pressure glaucoma, and whether age-related macular degeneration influences the appearance of the optic nerve head in experimental chronic high-pressure glaucoma in older rhesus monkeys.


METHODS
The longitudinal study included 102 eyes of 52 rhesus monkeys. The total study group was divided into a group with experimentally induced unilateral chronic high-pressure glaucoma (n = 40 eyes) and a normal control group (n = 62 eyes). Additionally, arterial hypertension and atherosclerosis were experimentally induced in both study groups in a similar percentage of monkeys. Mean monkey age at the end of the study was 19.6 +/- 3.1 years (range, 13-24 years). The macular region, optic disc, and retinal nerve fiber layer were morphometrically evaluated by color wide-angle fundus photographs taken at baseline and at the end of the study.


RESULTS
The degree of age-related macular degeneration, measured as number and area of drusen in the foveal and extrafoveal region of the macula, did not differ significantly between the two study groups. In the glaucomatous group, the degree of macular degeneration was statistically independent of the development of parapapillary atrophy, loss of neuroretinal rim, and decrease in the visibility of the retinal nerve fiber layer.


CONCLUSIONS
Development of age-related macular degeneration in rhesus monkeys is independent of concomitant chronic high-pressure glaucoma, including the development of glaucomatous parapapillary chorioretinal atrophy. Conversely, age-related macular degeneration does not markedly influence the course of experimental chronic high-pressure glaucoma or the development of parapapillary atrophy in monkeys.
Jonas
J B
JB
Department of Ophthalmology and Eye Hospital, Friedrich-Alexander University of Erlangen-Nürnberg, Germany.
Hayreh
S S
SS
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D002908:Chronic Disease; D004195:Disease Models, Animal; D005901:Glaucoma / Q000473:pathology / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology; D007429:Intraocular Pressure; D008253:Macaca mulatta; D008268:Macular Degeneration / Q000473:pathology / Q000503:physiopathology*; D009412:Nerve Fibers / Q000473:pathology; D009896:Optic Atrophy / Q000503:physiopathology; D009898:Optic Disk / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000473:pathology