title: Palmar fasciitis and polyarthritis associated with gastric carcinoma: complete resolution after total gastrectomy.
abstract: Palmar fasciitis and polyarthritis (PFA) is a rare paraneoplastic rheumatic syndrome characterized by flexion contractures of both hands and thickening of palmar fascia. Several reports have suggested that this syndrome is a tumor-associated autoimmune disorder. We report a 44-year-old Japanese man who presented with flexion contractures of both hands associated with thickening of palmar fascia and polyarthritis. These clinical pictures were suggestive of PFA associated with occult neoplasm. Upper gastrointestinal endoscopic examination revealed advanced gastric cancer. Resection of the cancer resulted in a gradual resolution of palmar fasciitis and polyarthritis. This clinical course suggests an underlying tumor-related immunologic process in this syndrome.
authors.affiliation: Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki.
authors.forename: M
authors.initials: M
authors.lastname: Enomoto
authors.forename: H
authors.initials: H
authors.lastname: Takemura
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Yuhara
authors.forename: T
authors.initials: T
authors.lastname: Akama
authors.forename: K
authors.initials: K
authors.lastname: Yamane
authors.forename: T
authors.initials: T
authors.lastname: Sumida
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000328:Adult; D005208:Fasciitis / Q000209:etiology* / Q000503:physiopathology; D005743:Gastrectomy; D006225:Hand; D006801:Humans; D008297:Male; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology* / Q000503:physiopathology; D010257:Paraneoplastic Syndromes; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery