Heparan sulphate. Regulation of growth factors in the mammary gland.
Heparan sulphate (HS) is a linear glycosaminoglycan found ubiquitously on the surface and in the pericellular matrix of metazoan cells that is covalently attached to core proteins to form HS proteoglycans. HS interacts specifically with a large number (> 100) of extracellular regulatory proteins, many of which are key players in mammary development and function. HS thus acts a receptor, in which capacity it regulates the bioavailability, localisation and activity of these regulatory proteins.
Bateman
K L
KL
School of Biological Sciences, University of Liverpool, UK.
Delehedde
M
M
Sergeant
N
N
Wartelle
I
I
Vidyasagar
R
R
Fernig
D G
DG
D000818:Animals; D001940:Breast / Q000378:metabolism*; D005260:Female; D006133:Growth Substances / Q000378:metabolism*; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D008321:Mammary Glands, Animal / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
D006133:Growth Substances; D006497:Heparan Sulfate; D011956:Receptors, Cell Surface