[Experimental evidence of an antihypertensive and hypocholesterolemic effect of oil of argan, Argania sideroxylon].
The chronic ingestion of 5 ml/kg/d of Argan oil by spontaneously hypertensive rats restores normal blood pressure and induces hypocholesterolaemia. In order to confirm these results Meriones shawi, a rodent of the Gerbillideae family, was tested as a second animal model. Meriones submitted to a hypercaloric diet and physical inactivity became fat, and exhibited hypertension, dyslipidaemia and hyperinsulinaemia. When treated for two months with the same dosage regimen, decreases in glycaemia, total plasmatic cholesterol, LDL, insulinaemia and systolic and diastolic blood pressures of 4.4 per cent, 14.4 per cent, 32.5 per cent, 26.8 per cent, 28.8 per cent and 30.5 per cent were simultaneously observed. Increases in LDH and of TG of 27.9 per cent and 16.2 per cent respectively were also observed. No effect on body weight occurred. The action of polyunsatured fatty acids of the Argan oil is predominant, but in addition, other constituents play an active part.
Berrada
Y
Y
Settaf
A
A
Baddouri
K
K
Cherrah
A
A
Hassar
M
M
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D005849:Gerbillinae; D008055:Lipids / Q000097:blood; D010938:Plant Oils / Q000494:pharmacology*; D010946:Plants, Medicinal
D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents; D008055:Lipids; D010938:Plant Oils