Effect of hydroxypropyl-beta-cyclodextrin on hydrocortisone dissolution from films intended for ocular drug delivery.
The formation of an inclusion complex between hydrocortisone and hydroxypropyl-beta-cyclodextrin can affect the in vitro transfer rate of hydrocortisone from the aqueous to the organic phase. The observed first order transfer rate constants showed that the complexation of hydrocortisone with hydroxypropyl-beta-cyclodextrin decreased significantly the transport of the drug depending on the partition coefficient of the drug, and the relative magnitude of the stability constant of the inclusion complex. To optimize the ocular drug delivery, high molecular weight cellulosis and PVA polymeric films were prepared. No unified mathematical model can predict the release profile of drug and complex from films. The drug and complex-polymer interactions in each system could be responsible for the solubility of the drug, and different release behaviours of hydrocortisone and cyclodextrin inclusion complex from the films prepared.
Bećirević-Laćan
M
M
Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry University of Zagreb, Croatia.
Filipović-Grcić
J
J
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D005079:Excipients; D006854:Hydrocortisone / Q000008:administration & dosage / Q000737:chemistry*; D007700:Kinetics; D009883:Ophthalmic Solutions; D012995:Solubility; D047392:beta-Cyclodextrins
D000893:Anti-Inflammatory Agents; D003505:Cyclodextrins; D005079:Excipients; D009883:Ophthalmic Solutions; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D006854:Hydrocortisone