title: Deliberate self poisoning with antidepressant drugs: a comparison of the relative hospital costs of cases of overdose of tricyclics with those of selective-serotonin re-uptake inhibitors.
abstract: BACKGROUND
  Debate continues over the relative merits of tricyclics and selective serotonin re-uptake inhibitors (SSRIs) as first line antidepressant treatment for depression. SSRIs are safer in overdose but more expensive than tricyclics. This report compared the hospital costs of cases of overdose with both groups of drug.
  
  
  METHODS
  Records of all persons aged over thirteen years presenting to a general hospital in one year were analysed for demographic information and details of their attendance.
  
  
  RESULTS
  There were 1165 episodes of self-poisoning, 151 involving tricyclics as the sole antidepressant and 69 SSRIs as the sole antidepressant. Those taking SSRIs had a shorter (1.96 vs. 2.59 days) and less expensive ( pound330 vs. pound567) stay. A large proportion of this difference in cost was due to a small number of admissions to the Intensive Care Unit.
  
  
  CONCLUSIONS
  This study used only hospital costs, so excluding costs associated with primary care.
  
  
  CONCLUSIONS
  If there were similar cost differences countrywide, the difference in hospital costs of self poisoning with SSRIs and tricyclics would represent an additional pound3.87 million per year due to self poisoning with tricyclics across the whole of England and Wales. This is a small proportion of the estimated pound100 million cost of switching to first-line prescribing of SSRIs for depression.
authors.affiliation: Child and Family Psychiatric Service, Sue Nicholls Centre, Manor House, Bierton Road, HP20 1EG, Aylesburg, UK.
authors.forename: P
authors.initials: P
authors.lastname: Ramchandani
authors.forename: B
authors.initials: B
authors.lastname: Murray
authors.forename: K
authors.initials: K
authors.lastname: Hawton
authors.forename: A
authors.initials: A
authors.lastname: House
mesh_terms: D000293:Adolescent; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000191:economics / Q000506:poisoning*; D003863:Depression / Q000188:drug therapy; D062787:Drug Overdose / Q000191:economics* / Q000628:therapy; D005260:Female; D017721:Hospital Costs; D006801:Humans; D007362:Intensive Care Units / Q000191:economics; D007902:Length of Stay; D008297:Male; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000191:economics / Q000506:poisoning*; D006113:United Kingdom
chemical_list: D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors