[Radiotherapy of cerebellar medulloblastoma in children].
Out of 108 children with brain tumors, aged 3-15, receiving radiotherapy in 191-1997, cerebral medulloblastoma was identified in 37 (34%). After total or subtotal excision of tumor, the latter were given 4-12 cycles of polychemotherapy. The brain and spinal marrow was exposed to 30-35 Gy followed by aiming 50-55 Gy irradiation of posterior cranial fossa. Three patients received radiation for recurrent tumor. One patient suffered demyelination as complication after repeated exposure. Out of 32 follow-up patients, 19 have survived an average of 33 months while 13 died having survived an average of 21 months. The main causes of failed therapy proved local progression of tumor and dissemination via liquor. Radical extent of surgery was used as the main prognostic factor.
Shcherbenko
O I
OI
Russian Center for Roentgeno-Radiology Research, Ministry of Health of the RF, Moscow.
Zelinskaia
N I
NI
Parkhomenko
R A
RA
Ardatova
G V
GV
Hechaeva
V N
VN
D000293:Adolescent; D001932:Brain Neoplasms / Q000532:radiotherapy; D002528:Cerebellar Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D018237:Germinoma / Q000532:radiotherapy; D005910:Glioma / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy* / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D017599:Neuroectodermal Tumors / Q000532:radiotherapy; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis; D016896:Treatment Outcome