title: Efficacy of oral iodised oil is associated with anthropometric status in severely iodine-deficient schoolchildren in rural Malawi.
abstract: The effect of anthropometric status on the efficacy of an oral supplement of iodised oil (1 ml Lipiodol Ultrafluide, 490 mg I; Laboratoire Guerbet, Aulnay-sous-Bois, France) was examined in 8-10-year-old schoolchildren (n 197) of Ntcheu, a severely I-deficient district of Malawi. The study was a controlled trial using the I concentration of casual urine samples to monitor the I status. The median urinary I concentration increased from 0.15 micromol/l at baseline (51.3 % of children < 0.16 micromol/l, 89.7 % < 0.40 micromol/l, 95.7 % 0.79 micromol/l) to 0.32 micromol/l at 40 weeks (29.1 % of the children < 0.16 micromol/l, 71.0 % < 0.40 micromol/l, 96.1 % < 0.79 micromol/l) while the total goitre prevalence fell from 63 % to 21 %. Variables of efficacy were estimated from a hyperbolic function describing the longitudinal pattern of urinary I excretion after the dose. The I retention and I elimination rate, and the periods of protection from mild (< 0.79 micromol/l) or moderate (< 0.40 micromol/l) I deficiency were obtained for groups of children with differing anthropometric status at baseline. Initial height-for-age and mid upper-arm circumference were not significantly related to efficacy. However, both the I retention and I elimination rate were reduced in children with lower initial weight-for-height. Children with lower skinfold thickness at baseline also had reduced I retention, which resulted in shorter protection periods from recurrent moderate and mild I deficiency. The efficacy of the oral iodised-oil supplement was not related to changes in anthropometric status during follow-up, nor was it related to the consumption of a food supplement of 1610 kJ immediately before the iodised-oil dose. Very low (< 0.16 micromol/l) urinary I concentration, and the presence of goitre at baseline were both associated with higher I retention and elimination rate. Children with goitre at baseline were found to have a prolonged duration of protection against recurrent moderate I deficiency. We conclude that in apparently healthy schoolchildren in I-deficient areas, general anthropometric status has a little influence on the efficacy of oral iodised oil for correcting I deficiency.
authors.affiliation: Department of Human Nutrition and Epidemiology, Wageningen Agricultural University, PO Box 8129 6700 EV, Wageningen, The Netherlands. cfurnee@hotmail.com
authors.forename: C A
authors.initials: CA
authors.lastname: Furnée
authors.forename: C E
authors.initials: CE
authors.lastname: West
authors.forename: F
authors.initials: F
authors.lastname: van Der Haar
authors.forename: J G
authors.initials: JG
authors.lastname: Hautvast
mesh_terms: D000284:Administration, Oral; D001827:Body Height; D001835:Body Weight; D002648:Child; D019587:Dietary Supplements / Q000032:analysis*; D006801:Humans; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D007459:Iodized Oil / Q000008:administration & dosage* / Q000378:metabolism*; D012423:Rural Health; D012885:Skinfold Thickness; D016896:Treatment Outcome
chemical_list: D007459:Iodized Oil; D007455:Iodine