title: Characterization of a novel member of the FGFR family, HrFGFR, in Halocynthia roretzi.
abstract: The cDNA for a novel member of the FGFR family, named HrFGFR, was isolated from a Halocynthia roretzi cDNA library prepared at the mid-tailbud stage. This cDNA was 3507b long, and the deduced amino acid sequence contained a motif characteristic of the vertebrate FGFRs. The existence of a single copy of the FGFR homologue gene in H. roretzi was suggested by restriction site analysis of multiple clones. HrFGFR mRNA was expressed strongly in the posterior region in the epidermis from the middle neurula stage. By contrast, Xenopus FGFR homologues are expressed in the anterior region and are known to induce anterior neural formation. A transition of the region expressing FGFR might have induced the more complicated brain or head formation characteristic of vertebrates.
authors.affiliation: Department of Immunology, School of Life Science, Yonago, 683-8503, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kamei
authors.forename: I
authors.initials: I
authors.lastname: Yajima
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: A
authors.initials: A
authors.lastname: Kobayashi
authors.forename: K W
authors.initials: KW
authors.lastname: Makabe
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: S I
authors.initials: SI
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Kunisada
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D014561:Urochordata / Q000235:genetics*; D014981:Xenopus
chemical_list: D018076:DNA, Complementary; D017468:Receptors, Fibroblast Growth Factor