Beryllium-induced toxicity and its prevention by treatment with chelating agents.
The efficacy of Tiron and calcium disodium EDTA in the treatment of experimental beryllium intoxication was investigated in rats. Beryllium nitrate was administered intramuscularly (50 mg kg(-1)) once only, provoking duration-dependent changes. Maximum changes were recorded after a 7-day regimen. Considerable inhibition was recorded in protein and glycogen contents, as well as in the activity of alkaline phosphatase, glucose-6-phosphatase, acid phosphatase and lipid peroxidation. These parameters were restored considerably with chelation therapy, but comparatively Tiron offered better protection. These findings were further confirmed by atomic adsorption spectrophotometry. Tiron was found to be significantly more effective than CaNa(2)EDTA in reducing the beryllium concentration in the liver, kidney and lungs.
Sharma
P
P
School of Studies in Zoology, Jiwaji University, Gwalior, India.
Johri
S
S
Shukla
S
S
D014013:1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D001607:Berylliosis / Q000378:metabolism / Q000517:prevention & control*; D001608:Beryllium / Q000493:pharmacokinetics / Q000633:toxicity*; D002614:Chelating Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004492:Edetic Acid / Q000627:therapeutic use; D005260:Female; D011868:Radioisotopes / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D002614:Chelating Agents; D011868:Radioisotopes; D014013:1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; D004492:Edetic Acid; D001608:Beryllium