Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus.
Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.
Entenza
J M
JM
Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
Foster
T J
TJ
Ni Eidhin
D
D
Vaudaux
P
P
Francioli
P
P
Moreillon
P
P
D018829:Adhesins, Bacterial / Q000502:physiology*; D000818:Animals; D004697:Endocarditis, Bacterial / Q000209:etiology*; D005340:Fibrinogen / Q000378:metabolism*; D051381:Rats; D013203:Staphylococcal Infections / Q000209:etiology*
D018829:Adhesins, Bacterial; D005340:Fibrinogen