title: Comparison of macular versus paramacular retinal sensitivity to femtosecond laser pulses.
abstract: Single 130 fs laser pulses in the near-IR (800 nm) were used to create ophthalmoscopically viewed minimum visible lesions (MVLs) within the macular and paramacular regions in rhesus monkey eyes. MVL thresholds at 1 and 24 h are reported as the 50% probability for damage (ED50) together with their fiducial limits at the 95% confidence level. These measured thresholds are compared with previously reported thresholds for near-IR and visible wavelengths for both macular and paramacular areas. Threshold doses were lower at the 24 h reading than at the 1 h reading for both retinal regions and the ED50s for the macula were slightly lower than for the paramacula. We measured the 24 h MVL ED50 thresholds to be 0.35 and 0.55 microJ for the macular and paramacular areas, respectively. The combined data for both areas yielded a threshold of 0.45 microJ.
authors.affiliation: Litton-TASC, Inc., San Antonio, Texas 78228, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Cain
authors.forename: C A
authors.initials: CA
authors.lastname: Toth
authors.forename: R J
authors.initials: RJ
authors.lastname: Thomas
authors.forename: G D
authors.initials: GD
authors.lastname: Noojin
authors.forename: V
authors.initials: V
authors.lastname: Carothers
authors.forename: D J
authors.initials: DJ
authors.lastname: Stolarski
authors.forename: B A
authors.initials: BA
authors.lastname: Rockwell
mesh_terms: D000818:Animals; D005131:Eye Injuries / Q000209:etiology / Q000517:prevention & control; D007834:Lasers / Q000009:adverse effects; D008253:Macaca mulatta; D008266:Macula Lutea / Q000502:physiology*; D009887:Ophthalmoscopy / Q000379:methods; D015203:Reproducibility of Results; D012160:Retina / Q000293:injuries; D012684:Sensory Thresholds / Q000502:physiology