title: Analgesic activity of cyclic imides: 1,8-naphthalimide and 1,4,5,8-naphthalenediimide derivatives.
abstract: In early studies, we have reported the synthesis and biological activities of several cyclic imides. The present study describes the analgesic activity of 1,8-naphthalimide and 1,4,5,8-naphthalenediimide derivatives in a standard murine model of analgesia. The pharmacological results show that all compounds studied, given intraperitoneally, produced significant inhibition of acetic acid-induced abdominal constrictions. At the ID50 (micromol/kg) level, these cyclic imide derivatives were about 40-270-fold more potent in this assay than aspirin and acetaminophen, two well-known and widely used analgesics. These results extend previous studies on the analgesic activity of cyclic imides.
authors.affiliation: Department of Chemistry, Universidade Federal de Santa Catarina, Florianópolis, Brazil. aandrico@umich.edu
authors.forename: A D
authors.initials: AD
authors.lastname: Andricopulo
authors.forename: L A
authors.initials: LA
authors.lastname: Müller
authors.forename: V C
authors.initials: VC
authors.lastname: Filho
authors.forename: G S
authors.initials: GS
authors.lastname: Cani
authors.forename: J F
authors.initials: JF
authors.lastname: Roos
authors.forename: R
authors.initials: R
authors.lastname: Corrêa
authors.forename: A R
authors.initials: AR
authors.lastname: Santos
authors.forename: R J
authors.initials: RJ
authors.lastname: Nunes
authors.forename: R A
authors.initials: RA
authors.lastname: Yunes
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives*; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007094:Imides / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure
chemical_list: D000700:Analgesics; D007094:Imides; D015057:1-Naphthylamine