title: Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia.
abstract: The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on to develop a highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ hybridization (FISH) and the MLL/AF4 rearrangement by reverse transcriptase-polymerase chain reaction (RT-PCR).
authors.affiliation: Hematology Department, Hospital Clínico San Carlos, Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Anguita
authors.forename: C G
authors.initials: CG
authors.lastname: Barrio
authors.forename: F A
authors.initials: FA
authors.lastname: González
authors.forename: M T
authors.initials: MT
authors.lastname: Ferro
authors.forename: E
authors.initials: E
authors.lastname: del Potro
authors.forename: P
authors.initials: P
authors.lastname: Ropero
authors.forename: A
authors.initials: A
authors.lastname: Villegas
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D020732:Cytogenetic Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein; D009687:Nuclear Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010198:Pancytopenia / Q000235:genetics / Q000473:pathology*; D011519:Proto-Oncogenes; D014157:Transcription Factors; D014178:Translocation, Genetic; D014314:Trisomy
chemical_list: D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; C497422:KMT2A protein, human; C489901:MLLT3 protein, human; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase