Role of inducible nitric oxide synthase in resistance to Mycobacterium leprae in mice.
The manifestation of leprosy in humans is largely determined by host immunity to Mycobacterium leprae and is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study explored M. leprae infection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.
Adams
L B
LB
National Hansen's Disease Programs, Laboratory Research Branch at Louisiana State University, Baton Rouge, Louisiana 70894, USA. ladams1@lsu.edu
Job
C K
CK
Krahenbuhl
J L
JL
D000818:Animals; D006801:Humans; D007918:Leprosy / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D019001:Nitric Oxide Synthase / Q000502:physiology*; D052247:Nitric Oxide Synthase Type II
C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse