[Leptin and stress protein (heat shock protein 72: HSP72) in patients with obstructive sleep apnea-hypopnea syndrome].
Leptin is a circulating hormone that is expressed abundantly and specifically in adipose tissue. Leptin induces a complex response involving control of body weight, energy expenditure and fat distribution. It is difficult for patients with obstructive sleep apnea-hypopnea syndrome to reduce and maintain their weights. Therefore, it is important to understand the circadian rhythms and regulation of serum leptin levels in order to control the body weight of obstructive sleep apnea-hypopnea syndrome (OSAHS) patients. Heat shock protein(HSP) 72 is generally known to be a stress-inducible isoform that is barely detectable under unstressed conditions but which is rapidly synthesized during or after stress. Recent data suggest that OSAHS may have significant effects on the serum leptin levels and HSP72 levels in peripheral blood mononuclear cells(PBMC) of patients with OSAHS.
Chin
K
K
Department of Physical Therapeutics, Kyoto University Hospital of Medicine.
D000273:Adipose Tissue / Q000378:metabolism; D001835:Body Weight; D002940:Circadian Rhythm; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D020181:Sleep Apnea, Obstructive / Q000097:blood*; D013312:Stress, Physiological
D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D020738:Leptin