title: The character or the variation: the genetic analysis of the insecticide-resistance phenotype.
abstract: In this critique it is argued that the genetic basis of the evolution of resistance is dependent on how the phenotypic, and underlying genotypic, variation is channelled during a selective response. A polygenic response is preferentially favoured if selection acts within the phenotypic distribution of susceptibles; a monogenic response is predicted if selection screens rare mutations with phenotypes outside that susceptible distribution. The relevance of this model to the method of genetic analysis, the prediction of resistance mechanisms to novel insecticides, the generation of resistant beneficial insects and the development of the most effective resistance and integrated pest management programmes is discussed.
authors.affiliation: Centre for Environmental Stress and Adaptation Research, Department of Genetics, University of Melbourne, Parkville 3010, Australia. j.mc_kenzie@genetics.unimelb.edu.au
authors.forename: J A
authors.initials: JA
authors.lastname: McKenzie
mesh_terms: D000818:Animals; D005544:Forecasting; D014644:Genetic Variation; D007305:Insecticide Resistance / Q000235:genetics*; D010641:Phenotype