[Na+/Ca+ exchange: structure, mechanism, regulation and function].
The Na+/Ca2+ exchange is a plasma membrane system for the countertransport of Na+ and Ca2+ ions. The system can transport Ca2+ both into and out of the cell and therefore it plays a crucial role in the calcium homeostasis. The system works in electrogenic way (3 Na+ are exchanged for 1 Ca2+) and thus it influences the electrogenic properties of excitable cells. Due to new techniques of electrophysiology and molecular biology a lot of information about transport mechanism, regulation and possible physiological and pathophysiological roles of the exchanger was accumulated. This review summarises new findings and shows progress in this attractive field of biological research.
Stengl
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M
Fyziologický ústav LF UK, Plzen. stengl@lfp.cuni.cz
Pucelík
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D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism; D006801:Humans; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D019831:Sodium-Calcium Exchanger; D012964:Sodium; D002118:Calcium