title: [Early detection of prostatic carcinoma in urologic practice with digital rectal examination and prostate-specific antigen. Early Detection Project Group].
abstract: For the early detection of prostate cancer, a patient should undergo digital rectal examination (DRE) and PSA investigation. Follow-up of increased PSA levels detects nearly 80% of cancers. Positive predictive value of suspicious DRE and PSA is about 50%. Whereas in the first evaluation of this case-finding trial about 70% of the patients had organ-confined cancers, nearly all of the detected cancers in the follow-up investigation were organ confined. The increased number of organ-confined cancers detected in early periodical examinations can lead to a reduction of mortality and morbidity from prostate cancer.
authors.affiliation: Urologische Klinik und Poliklinik, Universität-GH-Essen.
authors.forename: H J
authors.initials: HJ
authors.lastname: Luboldt
authors.forename: J
authors.initials: J
authors.lastname: Hüsing
authors.forename: J E
authors.initials: JE
authors.lastname: Altwein
authors.forename: K H
authors.initials: KH
authors.lastname: Bichler
authors.forename: D
authors.initials: D
authors.lastname: Czaja
authors.forename: P
authors.initials: P
authors.lastname: Fornara
authors.forename: K H
authors.initials: KH
authors.lastname: Jöckel
authors.forename: K
authors.initials: K
authors.lastname: Schalkhäuser
authors.forename: L
authors.initials: L
authors.lastname: Weissbach
authors.forename: M
authors.initials: M
authors.lastname: Wirth
authors.forename: H
authors.initials: H
authors.lastname: Rübben
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010173:Palpation; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen