Effect of cyclic GABA derivative TZ-146 on the content of neurotransmitters in rat brain stem.
The effect of cyclic GABA derivative TZ-146 on the content of catecholamines, serotonin, their metabolites, and neurotransmitter amino acids in rat hypothalamus and brain stem was studied by high-performance liquid chromatography with electrochemical detection. Opposite changes in the content of homovanillic acid, aspartate, glutamate, and glycine in the examined structures were accompanied by inhibition of dopamine metabolism. Possible participation of cerebral glutamatergic system in the effect of TZ-146 is discussed.
Uvarov
A V
AV
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Kudrin
V S
VS
Malikova
L A
LA
Narevich
V B
VB
Galenko-Yaroshevskii
P A
PA
D000818:Animals; D001933:Brain Stem / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*
D018377:Neurotransmitter Agents; C432603:TZ-146; D005680:gamma-Aminobutyric Acid