title: New types of X-ray computed tomography (CT) with synchrotron radiation: fluorescent X-ray CT and phase-contrast X-ray CT using interferometer.
abstract: New types of X-ray computed tomography (CT), fluorescent X-ray CT and phase-contrast X-ray CT are being developed for biomedical research. While fluorescent scanning X-ray CT (FXCT) can detect specific contrast elements, or endogenous iodine, at very low content (less than 400 pg iodine of tissue in a volume of 8 x 10(-6) ml), the phase-contrast X-ray CT (PCCT) is a highly sensitive imaging technique to differentiate between different biological tissue types (based on their specific gravity variation) without the use of a contrast agent. Therefore, we can expect functional diagnosis with FXCT, and high contrast, high resolution biological imaging with PCCT. In this paper, a human thyroid gland imaged by FXCT, and a metastatic human cancerous lesion depicted using PCCT are presented. The latter method used a newly manufactured, large, monolithic, X-ray interferometer, which is described in this paper in detail.
authors.affiliation: Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. ttakeda@md.tsukuba.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: A
authors.initials: A
authors.lastname: Momose
authors.forename: Q
authors.initials: Q
authors.lastname: Yu
authors.forename: T
authors.initials: T
authors.lastname: Yuasa
authors.forename: F A
authors.initials: FA
authors.lastname: Dilmanian
authors.forename: T
authors.initials: T
authors.lastname: Akatsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Itai
mesh_terms: D003110:Colonic Neoplasms; D006801:Humans; D007455:Iodine / Q000378:metabolism; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D008856:Microscopy, Fluorescence / Q000295:instrumentation / Q000379:methods; D008858:Microscopy, Phase-Contrast / Q000295:instrumentation / Q000379:methods; D019047:Phantoms, Imaging; D017356:Synchrotrons / Q000295:instrumentation; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D007455:Iodine