title: PLAC1, an Xq26 gene with placenta-specific expression.
abstract: A novel human X-linked gene shows placenta-specific expression and has been named PLAC1. The gene maps 65 kb telomeric to HPRT at Xq26 and has been completely sequenced at the cDNA and genomic levels. The mouse orthologue Plac1 maps to the syntenically equivalent region of the mouse X chromosome. In situ hybridization studies with the antisense mRNA during mouse embryogenesis detect Plac1 expression from 7.5 dpc (days postcoitum) to 14.5 dpc in ectoplacental cone, giant cells, and labyrinthine trophoblasts. The putative human and murine PLAC1 proteins are 60% identical and 77% homologous. Both include a signal peptide and a peptide sequence also found in an interaction domain of the ZP3 (zona pellucida 3) protein. These results make PLAC1 a marker for placental development, with a possible role in the establishment of the mother-fetus interface.
authors.affiliation: Laboratory of Genetics, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cocchia
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: S
authors.initials: S
authors.lastname: Pantano
authors.forename: E Y
authors.initials: EY
authors.lastname: Chen
authors.forename: P
authors.initials: P
authors.lastname: Ma
authors.forename: A
authors.initials: A
authors.lastname: Forabosco
authors.forename: M S
authors.initials: MS
authors.lastname: Ko
authors.forename: D
authors.initials: D
authors.lastname: Schlessinger
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D005314:Embryonic and Fetal Development; D020224:Expressed Sequence Tags; D018507:Gene Expression Regulation, Developmental; D015726:Giant Cells / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010920:Placenta / Q000378:metabolism*; D011257:Pregnancy Proteins / Q000737:chemistry / Q000235:genetics*; D016372:RNA, Antisense; D012333:RNA, Messenger / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D014327:Trophoblasts / Q000378:metabolism; D014960:X Chromosome
chemical_list: C415583:PLAC1 protein, human; D011257:Pregnancy Proteins; D016372:RNA, Antisense; D012333:RNA, Messenger