Epitheliotropic lymphoma (mycosis fungoides) presenting as blepharoconjunctivitis in an Irish setter.
An 11-year-old neutered female Irish setter was presented with a six-week history of blepharoconjunctivitis affecting the right eye. A conjunctival biopsy was taken and histopathological examination revealed a heavy cellular infiltrate involving the epithelial and subepithelial tissues. Immunohistochemical staining showed the intraepithelial cell population to uniformly have the phenotype CD3 (T-cell specific marker). A diagnosis of epitheliotropic lymphoma (mycosis fungoides) was made. The use of a synthetic retinoid and topical prednisolone in the management of the case is discussed.
Donaldson
D
D
Department of Pathology and Microbiology, School of Veterinary Science, University of Bristol, Langford.
Day
M J
MJ
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001762:Blepharitis / Q000175:diagnosis / Q000662:veterinary*; D017252:CD3 Complex / Q000032:analysis; D003231:Conjunctivitis / Q000175:diagnosis / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D009182:Mycosis Fungoides / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010641:Phenotype; D010859:Pigmentation Disorders / Q000175:diagnosis / Q000662:veterinary; D011239:Prednisolone; D012176:Retinoids / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D013601:T-Lymphocytes / Q000473:pathology
D000893:Anti-Inflammatory Agents; D017252:CD3 Complex; D012176:Retinoids; D011239:Prednisolone