Effect of natural antiphospholipid antibodies on antithrombotic activity of vascular wall.
Natural latent human antibodies cross-reacting with DNA and cardiolipin, interact with human endothelial cells, decrease antiaggregation activity of rat aortic wall, and increase fibrinolytic activity of the wall of the inferior vena cava. It is assumed that natural antiphospholipid antibodies present in immunoglobulin preparations in a latent state modify antithrombogenic activity of the vascular wall and are a potential cause of antiphospholipid syndrome.
Zyablitskii
V M
VM
Department of Radiation Biochemistry, Laboratory of Radiation Experimental Hematology, Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk.
Lekakh
I V
IV
Lyubina
L V
LV
Romanovskaya
V N
VN
Kabakov
A E
AE
Panarina
L V
LV
Poverennyii
A M
AM
D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D001011:Aorta / Q000276:immunology / Q000473:pathology; D002448:Cell Adhesion / Q000276:immunology; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000276:immunology* / Q000473:pathology; D006801:Humans; D010974:Platelet Aggregation / Q000276:immunology; D013927:Thrombosis / Q000276:immunology*
D017152:Antibodies, Antiphospholipid