[Malignant hyperthermia susceptibility in 3 patients with malignant neuroleptic syndrome].
Hyperthermia, skeletal muscle rigidity, rhabdomyolysis, acidosis and multiple system insufficiency characterize malignant hyperthermia. Anaesthetic malignant hyperthermia follows halogenated volatile agents and/or depolarizing muscle relaxants utilization. Diagnosis is based on in vitro muscle contracture in response to halothane and/or caffeine exposure. Neuroleptic malignant syndrome affects patients taking neuroleptic drugs; clinical findings include hyperthermia, extrapyramidal rigidity, acidosis, neurovegetative instability and neurological signs. We report three neuroleptic malignant syndrome patients with positive muscle contracture tests which shows that muscle from neuroleptic malignant syndrome patients may in some instances show alterations similar to those of anaesthetic malignant hyperthermia.
Silva
H C
HC
Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
Bahia
V S
VS
Oliveira
R A
RA
Marchiori
P E
PE
Scaff
M
M
Tsanaclis
A M
AM
D000328:Adult; D002110:Caffeine; D003286:Contracture / Q000209:etiology; D004198:Disease Susceptibility / Q000175:diagnosis; D005260:Female; D006221:Halothane; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000209:etiology*; D009459:Neuroleptic Malignant Syndrome / Q000150:complications*
D002110:Caffeine; D006221:Halothane