title: Headspace gas chromatographic determination of 1,3-butadiene in simulated saliva.
abstract: A headspace gas chromatographic (GC) method was developed to determine 1,3-butadiene (1,3-BD) in simulated saliva in contact with chewing gum. The calibration graph was linear, and the limit of detection was 0.004 mg/L, which is well below the migration limit for this substance. The headspace GC method provides rapid and reliable analysis for monitoring 1,3-BD migration from chewing gum into simulated saliva. In this paper, we report headspace methodology for sensitive determination of 1,3-BD in chewing gum and results of selected analyses, enabling preliminary assessment of possible exposure to 1,3-BD through migration.
authors.affiliation: Instituto Nacional de Controle de Qualidade em Saúde, Departamento de Química, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Abrantes
authors.forename: T C
authors.initials: TC
authors.lastname: Dos Santos
authors.forename: G
authors.initials: G
authors.lastname: Simões
authors.forename: S
authors.initials: S
authors.lastname: Abrantes
authors.forename: T C
authors.initials: TC
authors.lastname: Dos Santos
authors.forename: G
authors.initials: G
authors.lastname: Simões
mesh_terms: D002070:Butadienes / Q000032:analysis* / Q000737:chemistry; D002638:Chewing Gum / Q000032:analysis; D002849:Chromatography, Gas / Q000379:methods*; D011786:Quality Control; D012463:Saliva / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D002070:Butadienes; D002638:Chewing Gum; C031763:1,3-butadiene