title: [The immune response of viral hepatitis patients who use narcotic preparations].
abstract: The characteristics of cell-mediated and humoral immunity were studied in 611 patients with different etiological forms of acute virus hepatitides (HB, HC, HB + C, HC + HBsAg). As the result of the systematic abuse of psychoactive preparations, introduced by intravenous injection, in 166 patients (27.2%) drug addiction developed, ehile 445 (72.8%) patients had no addiction. The study revealed that in drug users with HB the secondary T-cell immunodeficiency of the hyposuppressor type in combination with depression in B-cell-mediated immunity (a decrease in the absolute number of B lymphocytes) could be registered, and in patients having no drug addiction the secondary T-cell immunodeficiency characterized by a decrease in the content of T helpers simultaneously with the increased content of T suppressors and B lymphocytes.
authors.affiliation: Research Institute of Epidemiology and Microbiology, Territorial Mental Health Center, Khabarovsk, Russia.
authors.forename: I S
authors.initials: IS
authors.lastname: Starostina
authors.forename: V V
authors.initials: VV
authors.lastname: Bogach
authors.forename: O E
authors.initials: OE
authors.lastname: Trotsenko
authors.forename: V I
authors.initials: VI
authors.lastname: Mikhaĭlov
authors.forename: G S
authors.initials: GS
authors.lastname: Tomilka
authors.forename: L A
authors.initials: LA
authors.lastname: Balakhontseva
authors.forename: V M
authors.initials: VM
authors.lastname: Durneva
authors.forename: V O
authors.initials: VO
authors.lastname: Kotov
authors.forename: V V
authors.initials: VV
authors.lastname: Fomenko
authors.forename: L M
authors.initials: LM
authors.lastname: Sokolovskiĭ
mesh_terms: D000208:Acute Disease; D000704:Analysis of Variance; D000917:Antibody Formation; D001782:Blood Donors; D006509:Hepatitis B / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D015999:Multivariate Analysis; D009293:Opioid-Related Disorders / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology