title: Thirty-day monitoring of insulin-like growth factors and their binding proteins in intensive care unit patients.
abstract: This study investigates the regulation of the insulin-like growth factors (IGFs) and their regulatory proteins in 14 critically ill patients during the 30-day period following admission to an intensive care unit (ICU). Levels of IGF-I, IGF-II, IGF binding protein-3 (IGFBP-3) and acid-labile subunit (ALS) were low on admission, and in the 8 patients whose serum IGF-I levels failed to increase over 30 days, levels of the other proteins also remained low, while IGFBP-3 proteolytic activity increased. Of these proteins, ALS correlated best with serum levels of nutritional indicators, particularly prealbumin. IGFBP-2 and IGFBP-6 levels tended to be high in critically ill patients, but showed little change over the 30-day period. In contrast, IGFBP-1 levels were high on admission, correlated with early changes in nitrogen balance, and fell rapidly during the first week. By demonstrating that the IGF-I response in ICU patients is related to changes in the IGF regulatory proteins, this study may be of value in planning therapeutic intervention using growth hormone or IGF-I.
authors.affiliation: Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia. robaxter@med.su.oz.au
authors.forename: R C
authors.initials: RC
authors.lastname: Baxter
authors.forename: F H
authors.initials: FH
authors.lastname: Hawker
authors.forename: C
authors.initials: C
authors.lastname: To
authors.forename: P M
authors.initials: PM
authors.lastname: Stewart
authors.forename: S R
authors.initials: SR
authors.lastname: Holman
mesh_terms: D000328:Adult; D000368:Aged; D002096:C-Peptide / Q000097:blood; D016638:Critical Illness; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000032:analysis / Q000378:metabolism*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013997:Time Factors
chemical_list: D002096:C-Peptide; D018969:Insulin-Like Growth Factor Binding Proteins; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone