A Fusobacterium mortiferum strain produces a bacteriocin-like substance(s) inhibiting Salmonella enteritidis.
Seven strictly anaerobic strains showing anti-Salmonella enteritidis activity were isolated from poultry caecal contents. Among them, the most inhibitory one, a strain of Fusobacterium mortiferum, called FM1025, was selected. Biochemical tests, showing the proteinaceous structure of the antagonist(s) produced, indicated that the strain Fus. mortiferum FM1025 synthesized (a) bacteriocin-like compound(s) active against Salm. enteritidis. Among the other strains tested, both Gram-negative and Gram-positive bacteria were inhibited. These preliminary results suggested the important role of the Fusobacterium strains against pathogenic bacteria among the intestinal flora.
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Laboratoire de Génie Protéique et Cellulaire, Université de La Rochelle, France.
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D000818:Animals; D001430:Bacteriocins / Q000096:biosynthesis / Q000494:pharmacology*; D002432:Cecum / Q000382:microbiology; D005673:Fusobacterium / Q000378:metabolism*; D011200:Poultry / Q000382:microbiology; D012477:Salmonella enteritidis / Q000187:drug effects* / Q000254:growth & development
D001430:Bacteriocins