Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk.
Plasma levels of alpha1-antichymotrypsin (ACT) and interleukin-1beta (IL-1beta) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-1beta genes affected plasma levels of ACT or IL-1beta, and AD patients with the ACT T,T or IL-1beta T,T genotype showed the highest levels of plasma ACT or IL-1beta, respectively. The concomitant presence of the ACT T,T and IL-1beta T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease.
Licastro
F
F
Dipartimento di Patologia Sperimentale, School of Medicine, University of Bologna, Italy.
Pedrini
S
S
Ferri
C
C
Casadei
V
V
Govoni
M
M
Pession
A
A
Sciacca
F L
FL
Veglia
F
F
Annoni
G
G
Bonafè
M
M
Olivieri
F
F
Franceschi
C
C
Grimaldi
L M
LM
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics*; D000704:Analysis of Variance; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D000514:alpha 1-Antichymotrypsin / Q000097:blood* / Q000235:genetics*
D007375:Interleukin-1; D000514:alpha 1-Antichymotrypsin