Glutathione S-transferase activity in the liver in acute pancreatitis at various terms of disease and during treatment with inducers.
Glutathione S-transferase activity increased in rats with acute pancreatitis: 2.2 times on day 2, 2-fold on day 4, and 1.5 times on day 10. Inducers of microsomal enzymes aroclor 1254 and phenobarbital notably inhibited glutathione S-transferase activity in animals with experimental pancreatitis on days 2-4 of the disease (3.1-2.5 times in comparison with sham-operated induced animals). Hence, the activity of enzymes of phase II of liver xenobiotic metabolism is altered in acute pancreatitis.
Prokop'eva
N V
NV
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Gulyaeva
L F
LF
D000208:Acute Disease; D000818:Animals; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D010195:Pancreatitis / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D015854:Up-Regulation
D005982:Glutathione Transferase