Low apolipoprotein A-IV plasma concentrations in men with coronary artery disease.
OBJECTIVE
The objective of this study was to evaluate the relation between apolipoprotein A-IV (apoA-IV) plasma concentrations and coronary artery disease (CAD).


BACKGROUND
Experimental in vitro and in vivo studies favor apoA-IV to be protective against the development of atherosclerosis. Mice that overexpress either human or mouse apoA-IV demonstrated a significant reduction of aortic atherosclerotic lesions compared with control mice. Data on apoA-IV plasma concentrations and CAD in humans are lacking.


METHODS
We determined in two independent case-control studies of a Caucasian and an Asian Indian population whether apoA-IV plasma concentrations are related to the presence of angiographically assessed CAD.


RESULTS
Plasma apoA-IV levels were significantly lower in 114 male Caucasian subjects with angiographically defined CAD when compared with 114 age-adjusted male controls (10.2 +/-3.8 mg/dL vs. 15.1 +/- 4.0 mg/dL, p < 0.001). Logistic regression analysis indicated that the association between apoA-IV levels and CAD was independent of the high-density lipoprotein cholesterol and triglyceride concentrations. The inverse relationship between plasma levels of apoA-IV and the presence of CAD was confirmed in an independent sample of 68 male Asian Indians with angiographically documented CAD and 68 age-matched controls.


CONCLUSIONS
The results of this cross-sectional study demonstrate for the first time an association between low apoA-IV concentrations and CAD in humans and suggest that apoA-IV may play an antiatherogenic role in humans.
Kronenberg
F
F
Institute of Medical Biology and Human Genetics, University of Innsbruck, Austria. Florian.Kronenberg@uibk.ac.at
Stühlinger
M
M
Trenkwalder
E
E
Geethanjali
F S
FS
Pachinger
O
O
von Eckardstein
A
A
Dieplinger
H
H
D001054:Apolipoproteins A / Q000097:blood*; D001317:Austria; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000208:ethnology; D003430:Cross-Sectional Studies; D005006:Ethnicity; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood; D044465:White People
D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D014280:Triglycerides; C022205:apolipoprotein A-IV