title: The genotype of human transcription factor AP-2beta is associated with platelet monoamine oxidase B activity.
abstract: Platelet monoamine oxidase B (MAO; EC 1.4.3.4.) activity is stable in the individual and is mainly genetically regulated. Levels of MAO-B in platelets have repeatedly been shown to be associated with personality traits. We have recently also demonstrated an association between the genotype of AP-2beta to a variety of personality traits as well as binge-eating disorder. In the present study we have analysed blood samples from 158 males and 64 females with regard to platelet MAO activity and genotype of transcription factor AP-2beta. In both sexes homozygotes for the long allele [CAAA](5) were significantly associated with low platelet MAO activity P<0.0001 (males) and P=0.0158 (females). This study represents a novel approach to increase the understanding about the molecular mechanisms for how the MAOB gene is regulated in blood cells and how this regulation is linked to personality traits.
authors.affiliation: Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Damberg
authors.forename: H
authors.initials: H
authors.lastname: Garpenstrand
authors.forename: C
authors.initials: C
authors.lastname: Berggârd
authors.forename: M
authors.initials: M
authors.lastname: Asberg
authors.forename: J
authors.initials: J
authors.lastname: Hallman
authors.forename: L
authors.initials: L
authors.lastname: Oreland
mesh_terms: D000483:Alleles; D000704:Analysis of Variance; D001792:Blood Platelets / Q000201:enzymology*; D002032:Bulimia / Q000201:enzymology / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D012737:Sex Factors; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D008995:Monoamine Oxidase