[The optimization of a plan for the photodynamic therapy of sarcoma M1 using photosens].
The study established the importance of optimal dosage, concentration and mode of administration of the drug Fotosens for the effectiveness of photodynamic therapy of tumor. Of similar importance is the interval between administration and irradiation to potentiate the drug's action. Failure to consider the latter factor may lower the effect dramatically or even reverse it. Experimental findings point to high antitumor potency of the drug. Preference should be given to injecting relatively low concentrations along the periphery of tumor, thus avoiding the undesirable cytostimulating effect and toxicity of Fotosens and saving on the drug. The potential of the treatment as a component of "white light" photodynamic therapy is discussed.
Lagoda
T S
TS
Kaplan
M A
MA
Krivosheev
Ia V
IaV
Zhavoronkov
L P
LP
Bokova
M B
MB
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D007211:Indoles / Q000008:administration & dosage* / Q000494:pharmacology; D009368:Neoplasm Transplantation; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D010778:Photochemotherapy / Q000379:methods*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012513:Sarcoma, Experimental / Q000188:drug therapy*; D013997:Time Factors
D000970:Antineoplastic Agents; D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C048577:aluminum tetrasulfophthalocyanine