Effects of fujibitol, a remedy for nasal symptoms, on experimental allergic rhinitis in rats.
The effects of Fujibitol, a preparation of crude drugs in wide clinical use for treatment of chronic rhinitis and empyema, on experimental allergic rhinitis in rats were studied. Fujibitol inhibited nasal allergic symptoms, i.e. sneezing and nasal rubbing, induced by antigen in sensitized animals. An increase in dye leakage into the nasal cavity induced by antigen was also inhibited by Fujibitol. On the other hand, no inhibitory effects were observed on either the nasal allergic symptoms or increase in dye leakage into the nasal cavity induced by histamine. However, Fujibitol was effective in inhibiting histamine release from the nasal cavity induced by antigen. Oxatomide used as positive control drug showed potent inhibitory effects on nasal symptoms and dye leakage into the nasal cavity induced by histamine and antigen. These results suggested that Fujibitol showed a remarkable protective effect against experimental rhinitis induced by antigen via inhibition of histamine release from the nasal cavity.
Kakimoto
M
M
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Sugimoto
Y
Y
Harada
M
M
Kobayashi
Y
Y
Okuma
C
C
Taga
C
C
Kamei
C
C
D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D010879:Piperazines / Q000627:therapeutic use; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D018926:Anti-Allergic Agents; C121689:Fujibitol; D010879:Piperazines; D010936:Plant Extracts; C015408:oxatomide