title: Regulation of the insulin-like growth factor-I receptor gene by oncogenes and antioncogenes: implications in human cancer.
abstract: The insulin-like growth factor-I receptor (IGF-I-R) has a central role in normal cellular proliferation as well as in transformation processes. Transcription of the IGF-I receptor gene is controlled by a number of tumor suppressors, including WT1, p53, and BRCA1. It has been demonstrated that, in their wild-type form, these transcription factors can suppress the activity of the IGF-I-R promoter, with ensuing reduction in the levels of cell-surface IGF binding. On the other hand, a number of oncogenes, including mutant p53 and c-myb, and the fusion protein EWS-WT1 significantly stimulate promoter activity. Interactions between stimulatory and inhibitory transcription factors may determine the level of expression of the IGF-I-R gene and, consequently, the proliferative status of the cell.
authors.affiliation: Department of Clinical Biochemistry, Tel Aviv University, Tel Aviv, 69978, Israel. hwerner@post.tau.ac.il
authors.forename: H
authors.initials: H
authors.lastname: Werner
authors.forename: M
authors.initials: M
authors.lastname: Shalita-Chesner
authors.forename: S
authors.initials: S
authors.lastname: Abramovitch
authors.forename: G
authors.initials: G
authors.lastname: Idelman
authors.forename: L
authors.initials: L
authors.lastname: Shaharabani-Gargir
authors.forename: T
authors.initials: T
authors.lastname: Glaser
mesh_terms: D017209:Apoptosis; D002453:Cell Cycle; D005786:Gene Expression Regulation; D016147:Genes, Tumor Suppressor; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics* / Q000517:prevention & control; D009857:Oncogenes; D017526:Receptor, IGF Type 1 / Q000235:genetics*; D013002:Somatomedins / Q000378:metabolism
chemical_list: D013002:Somatomedins; D017526:Receptor, IGF Type 1