title: Assessment of relationship between secretion of melatonin, activity of thyroid, adrenal cortex as well as testes and chosen markers of collagen metabolism in starved rats.
abstract: In starved rats the mutual interrelations were studied between the secretion of melatonin (MEL), thyroid hormones (TT[_4], FT[_4], TT[_3], FT[_3], rT[_3]), corticosterone (B), testosterone (T) and some markers of collagen metabolism: serum concentrations of carboxyterminal propeptide of type I procollagen (PICP) and aminoterminal propeptide of type III procollagen (PIIINP) (determined by RIA method) as well as urine concentration of hydroxyproline (OH-Pr) (determined by colorimetric method). Starved rats were found to have significantly increased serum MEL, B, and rT[_3] concentrations while serum values of TT[_4], FT[_4], TT[_3], FT[_3], T and PICP as well as urinary OH-Pr were significantly decreased. The concentrations of PICP, PIIINP and OH-Pr correlated negatively with MEL and B values, but positively with TT[_4] and FT[_4]. It was concluded that starving may change the collagen metabolism in rats indirectly via a modulating effect of changes in MEL, thyroxine and corticosterone.
authors.affiliation: 1st Department of Pathophysiology and Clinical Biochemistry, Silesian Academy of Medicine, 41-800 Zabrze, Poland.
authors.initials: Z
authors.lastname: Ostrowska
authors.initials: E
authors.lastname: Swientochowska
authors.initials: B
authors.lastname: Buntner
authors.initials: B
authors.lastname: Marek
authors.initials: K
authors.lastname: Zwirska-Korczala
authors.initials: Z
authors.lastname: Spyra
authors.initials: I
authors.lastname: Banas