Absolute configuration and antiprotozoal activity of minquartynoic acid.
Minquartynoic acid (1) was isolated as an antimalarial and antileishmanial constituent of the Peruvian tree Minquartia guianensis and its absolute configuration at C-17 established to be (+)-S through conversion to the known (+)-(S)-17-hydroxystearic acid (2) and confirmed using Mosher's method.
Rasmussen
H B
HB
Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark.
Christensen
S B
SB
Kvist
L P
LP
Kharazmi
A
A
Huansi
A G
AG
D000480:Alkynes; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D018320:Leishmania major / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D053279:Polyynes
D000480:Alkynes; D000981:Antiprotozoal Agents; D005231:Fatty Acids, Unsaturated; C417933:minquartynoic acid; D053279:Polyynes