Differences among mechanisms of ribozyme-catalyzed reactions.
The catalytic properties of ribozymes depend on the sophisticated structures of the respective ribozyme-substrate complexes. Although it has been suggested that ribozyme-mediated cleavage of RNA occurs via a rather strictly defined mechanism, recent findings have clearly demonstrated the diversity of reaction mechanisms.
Warashina
M
M
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Hongo, Japan.
Takagi
Y
Y
Stec
W J
WJ
Taira
K
K
D000143:Acids; D000818:Animals; D002384:Catalysis; D003698:Hepatitis Delta Virus / Q000235:genetics; D008670:Metals / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry* / Q000378:metabolism*; D013768:Tetrahymena / Q000235:genetics
D000143:Acids; D008670:Metals; D016337:RNA, Catalytic