title: Power-law modeling based on least-squares criteria: consequences for system analysis and simulation.
abstract: The power-law formalism was initially derived as a Taylor series approximation in logarithmic space for kinetic rate-laws. The resulting models, either as generalized mass action (GMA) or as S-systems models, allow to characterize the target system and to simulate its dynamical behavior in response to external perturbations and parameter changes. This approach has been succesfully used as a modeling tool in many applications from cell metabolism to population dynamics. Without leaving the general formalism, we recently proposed to derive the power-law representation in an alternative way that uses least-squares (LS) minimization instead of the traditional derivation based on Taylor series [B. Hernández-Bermejo, V. Fairén, A. Sorribas, Math. Biosci. 161 (1999) 83-94]. It was shown that the resulting LS power-law mimics the target rate-law in a wider range of concentration values than the classical power-law, and that the prediction of the steady-state using the LS power-law is closer to the actual steady-state of the target system. However, many implications of this alternative approach remained to be established. We explore some of them in the present work. Firstly, we extend the definition of the LS power-law within a given operating interval in such a way that no preferred operating point is selected. Besides providing an alternative to the classical Taylor power-law, that can be considered a particular case when the operating interval is reduced to a single point, the LS power-law so defined is consistent with the results that can be obtained by fitting experimental data points. Secondly, we show that the LS approach leads to a system description, either as an S-system or a GMA model, in which the systemic properties (such as the steady-state prediction or the log-gains) appear averaged over the corresponding interval when compared with the properties that can be computed from Taylor-derived models in different operating points within the considered operating range. Finally, we also show that the LS description leads to a global, accurate description of the system when it is submitted to external forcing.
authors.affiliation: Departamento de Física Matemática y Fluidos, Universidad Nacional de Educación a Distancia. Senda del Rey S/N, 28040, Madrid, Spain. bhernand@apphys.uned.es
authors.forename: B
authors.initials: B
authors.lastname: Hernández-Bermejo
authors.forename: V
authors.initials: V
authors.lastname: Fairén
authors.forename: A
authors.initials: A
authors.lastname: Sorribas
mesh_terms: D001699:Biometry; D004798:Enzymes / Q000378:metabolism; D007700:Kinetics; D016018:Least-Squares Analysis; D015233:Models, Statistical; D013597:Systems Analysis
chemical_list: D004798:Enzymes