Assessment of allodynia and hyperalgesia after cisplatin administration to rats.
This work describes the behavioural responses of Sprague-Dawley rats to mechanical or thermal stimuli during and after administration of ten intraperitoneal injections of, alternatively, 1 and 2 mg/kg cisplatin every three days (cumulative dose: 15 mg/kg). Nociceptive signs including mechanical allodynia and hyperalgesia appeared after 3 and 6 cisplatin injections, respectively, and were maintained until 15 days after the last injection. The conservation of a good clinical status and fast appearance of symptoms are favourable criteria for using this animal model to understand the pathophysiological mechanisms implicated in the cisplatin-induced sensory peripheral neuropathy.
Authier
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Laboratoire de Toxicologie, Faculté de Phamacie, Equipe NeuroPsychoPharmacologie Université d'Auvergne (NPPUA), INSERM EMI 9904, 28 place Henri Dunant, BP 38, 63001 cedex 01, Clermont-Ferrand, France.
Fialip
J
J
Eschalier
A
A
Coudoré
F
F
D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage*; D006358:Hot Temperature; D006930:Hyperalgesia / Q000503:physiopathology* / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000503:physiopathology* / Q000517:prevention & control; D010147:Pain Measurement; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000294:innervation; D013314:Stress, Mechanical
D002945:Cisplatin