[The beta-hCG subunit, CA 125 and CA 19-9 antigen in the women with non-trophoblastic malignancy of genital tract. Endometrial cancer].
OBJECTIVE
There are few conflicting reports in regards of markers appearing in the patients with endometrial cancer. The aim of this study was to evaluate the serum levels: CA 125 antigen, CA 19-9 antigen and beta-hCG subunit in this group of patients and comparing obtained results with normal controls.


METHODS
In both groups--with endometrial cancer (n = 43)- and controls-(n = 214)--CA125 antigen, CA 19-9 antigen and beta-hCG subunit the serum level were determined two = site of immunometric method. The differences of the means, correlations, specificity, sensitivity, positive predictive value, negative predictive value and efficiency were calculated.


RESULTS
The women with endometrial cancer exhibited the significantly higher level of all antigens. The positive correlation between CA 125 serum level and staging and grading and between beta-hCG subunit and endometrial cancer staging was found. The positive test had: specificity--62%, sensitivity--93%, positive predictive value--66%, negative predictive value--92% and efficiency--92.5%.


CONCLUSIONS
In the women with endometrial cancer appears non-specific antigens characteristic for the müllerian duct derivatives tissue, exhibiting Lewis blood group antigen and involving in membrane cell structures in normal and cancer cells. The level of these antigens correlates with grading and staging of the neoplasms.
Piela
A
A
Oddziału Ginekologii i Połoznictwa Wojewódzkiego Szpitala Specjalistycznego w Rzeszowie.
Lewandowska
M
M
D000328:Adult; D000951:Antigens, Neoplasm / Q000276:immunology*; D018394:CA-125 Antigen / Q000276:immunology*; D018395:CA-19-9 Antigen / Q000276:immunology*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000276:immunology* / Q000601:surgery; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000276:immunology / Q000601:surgery; D006801:Humans; D009367:Neoplasm Staging; D011237:Predictive Value of Tests
D000951:Antigens, Neoplasm; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D018997:Chorionic Gonadotropin, beta Subunit, Human