Spectrum of activity of sparfloxacin against local isolates.
OBJECTIVE
Determine the sensitivity pattern of local isolates to a new fluoroquinolone and MIC 90 of the isolates.


METHODS
Four hundred clinical isolates belonging to 21 genera were included in the study. Sensitivity was determined by disc difussion method and MIC by agar dilution method.


RESULTS
The in-vitro study of the sensitivity pattern of local isolates indicates that the isolates are susceptible to Sparfloxacin and the MIC 90 for common clinical isolates from various sites is lower than those achieved by the drug. The international data available also suggests that the drug could be very effective in difficult-to-treat infections.


CONCLUSIONS
It could be concluded from the study that Sparfloxacin is a useful drug for treating respiratory, entero and urinary pathogens due to its unique pharmacological profile.
Hafiz
S
S
Mid East Medical Center, Karachi.
Naseem
S
S
D000890:Anti-Infective Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D024841:Fluoroquinolones; C061363:sparfloxacin