7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.
The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
Buckley
G
G
Celltech-Chiroscience Ltd, Abington, Cambridge, UK.
Cooper
N
N
Dyke
H J
HJ
Galleway
F
F
Gowers
L
L
Gregory
J C
JC
Hannah
D R
DR
Haughan
A F
AF
Hellewell
P G
PG
Kendall
H J
HJ
Lowe
C
C
Maxey
R
R
Montana
J G
JG
Naylor
R
R
Picken
C L
CL
Runcie
K A
KA
Sabin
V
V
Tuladhar
B R
BR
Warneck
J B
JB
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D001549:Benzamides / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology; D001572:Benzofurans / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004802:Eosinophilia / Q000188:drug therapy; D006168:Guinea Pigs; D020128:Inhibitory Concentration 50; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology; D020889:Rolipram / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014839:Vomiting / Q000139:chemically induced
D001549:Benzamides; D001572:Benzofurans; D010726:Phosphodiesterase Inhibitors; D011725:Pyridines; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram; C087566:piclamilast