Evaluation of the antiulcerogenic activity of friedelan-3beta-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae).
An easy methodology for triterpene isolation is shown. Evaluation in rats for antiulcer activity of friedelan-3beta-ol 1 and friedelin 2. The two triterpenes isolated from the leaves of Maytenus ilicifolia, did not decrease gastric ulcers when tested on indometacine induced ulcer model in rats.
Queiroga
C L
CL
Divisão de Fitoquímica, Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas-CPQBA, Universidade Estadual de Campinas-UNICAMP, CP 6171, CEP 13081-970-Campinas, São Paulo, Brazil. queiroga@cpqba.unicamp.br
Silva
G F
GF
Dias
P C
PC
Possenti
A
A
de Carvalho
J E
JE
D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004341:Drug Evaluation; D008401:Gas Chromatography-Mass Spectrometry; D007213:Indomethacin / Q000009:adverse effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales / Q000737:chemistry*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000094042:Lupanes
D000897:Anti-Ulcer Agents; D007213:Indomethacin; D014315:Triterpenes; C419506:friedelan-3-ol; C060796:friedelin; D000094042:Lupanes