Is a mixture of gadolinium and iodinated contrast material safe during MR arthrography?
OBJECTIVE
This study was designed to determine whether a mixture of iodinated contrast material and gadopentetate dimeglumine used during MR arthrography yields free gadolinium ion, a systemically toxic metal.


METHODS
Mixtures of commercially available nonionic and ionic iodinated contrast agent, gadopentetate dimeglumine, lidocaine, and epinephrine were analyzed using a spectrophotometric titration with a gadolinium ion titrant and methyl thymol blue indicator.


RESULTS
We found no significant dissociation of gadolinium ion when gadopentetate dimeglumine was mixed with iodinated contrast agents, lidocaine, or epinephrine in any of the dilutions tested.


CONCLUSIONS
Gadopentetate dimeglumine and iodinated contrast material can be mixed before MR imaging without any release of free gadolinium and are therefore safe for confirming the intraarticular placement of contrast material before MR arthrography.
Brown
R R
RR
Department of Radiology, Cleveland Clinic, 3000 W. Cypress Creek Rd., Ft. Lauderdale, FL 33309, USA.
Clarke
D W
DW
Daffner
R H
RH
D001175:Arthrography; D003287:Contrast Media / Q000009:adverse effects*; D003974:Diatrizoate Meglumine / Q000009:adverse effects; D004347:Drug Interactions; D004492:Edetic Acid / Q000009:adverse effects; D019786:Gadolinium DTPA / Q000009:adverse effects*; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects; D007482:Iothalamate Meglumine / Q000009:adverse effects; D008279:Magnetic Resonance Imaging; D004369:Pentetic Acid / Q000009:adverse effects; D014677:Pharmaceutical Vehicles; D013053:Spectrophotometry
D003287:Contrast Media; D014677:Pharmaceutical Vehicles; D003974:Diatrizoate Meglumine; D004369:Pentetic Acid; D004492:Edetic Acid; D007479:Iopamidol; D019786:Gadolinium DTPA; D007482:Iothalamate Meglumine