Review of mammalian DNA repair and translational implications.
The area of mammalian DNA repair and its relationship to cancer and therapeutic approaches is rapidly growing, both through the studies of basic mechanisms and in the use of this knowledge for translational applications. We have attempted to briefly and succinctly cover the four pathways of mammalian DNA repair, which are: direct reversal, mismatch, nucleotide excision, and base excision repair. We have also tried to identify and reference results in the literature relating the various repair pathways to cellular resistance following chemotherapeutic treatments and to provide some potential direction whereby laboratory results may be applicable to clinical therapeutics, particularly for cancer treatments.
Hansen
W K
WK
Department of Pediatrics, Section of Hematology/Oncology, Herman B. Wells Center for Pediatric Research and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kelley
M R
MR
D000818:Animals; D020137:Base Pair Mismatch; D004260:DNA Repair; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000502:physiology
D019853:O(6)-Methylguanine-DNA Methyltransferase