title: UCF116, new inhibitors of farnesyltransferase produced by Streptomyces.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Co. Ltd., Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: S
authors.initials: S
authors.lastname: Soga
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Shono
authors.forename: J
authors.initials: J
authors.lastname: Eishima
authors.forename: T
authors.initials: T
authors.lastname: Mizukami
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000201:enzymology; D002417:Cattle; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D005285:Fermentation; D006873:Hydroquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007700:Kinetics; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D013329:Structure-Activity Relationship; D018631:ras Proteins / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D006873:Hydroquinones; C414186:UCF116 compound; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase; D018631:ras Proteins