Role of corticosterone in realization of immunosuppressive effects in acute poisoning with toxic chemicals.
Experiments on random-bred male rats shows that acute poisoning with metaphos and acrylonitrile inhibits mainly the thymus-dependent humoral immune response, delayed type hypersensitivity reaction, and activities of natural killers and K cells. The increase in plasma corticosterone under the effect of metaphos ensures the participation of this hormone in the realization of suppression of natural killers and thymus-dependent humoral immune response (production of IgG), the contribution of the hormone to this suppression being 35.6 and 35.1%, respectively. Suppression of immune reactions by acrylonitrile is not associated with corticosterone effect.
Zabrodskii
P F
PF
Department of Toxicology, Saratov State Medical University.
Germanchuk
V G
VG
D000181:Acrylonitrile / Q000633:toxicity; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D003345:Corticosterone / Q000276:immunology*; D007107:Immune System / Q000187:drug effects* / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity; D008297:Male; D008743:Methyl Parathion / Q000633:toxicity; D051381:Rats
D002273:Carcinogens; D007166:Immunosuppressive Agents; D007306:Insecticides; D008743:Methyl Parathion; D000181:Acrylonitrile; D003345:Corticosterone