Misfolding of membrane proteins in health and disease: the lady or the tiger?
Protein misfolding is increasingly recognized as a factor in many diseases, including cystic fibrosis, Parkinson's, Alzheimer's and atherosclerosis. Many proteins involved in misfolding-based pathologies are membrane-associated, such that the bilayer may play roles in normal and aberrant folding. It can be argued that the in vivo partitioning of eukaryotic membrane proteins between folding and misfolding pathways is under kinetic control. Moreover, the balance between these pathways can be surprisingly delicate.
Sanders
C R
CR
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4970, USA. crs@po.cwru.edu
Nagy
J K
JK
D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D003550:Cystic Fibrosis / Q000209:etiology / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism; D017510:Protein Folding; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D008565:Membrane Proteins