Lipid phosphatases in the immune system.
In the last 10 years we have come to appreciate the central role that phosphatidylinositol (PI)-3,4,5-P(3)plays in regulating a vast array of biological responses to extracellular signals. The level of this phospholipid is low in resting cells but increases rapidly in response to growth factor/cytokine-stimulated plasma membrane recruitment and activation of PI-3-kinase. Within the last 3 years three enzymes, SHIP, SHIP2 and PTEN, that play key roles in regulating the level of PI-3,4,5-P(3)have been cloned. In this review I have attempted to summarize our current knowledge regarding these three intriguing phosphatases.
Krystal
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Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3. gerry@terryfox.ubc.ca
D000818:Animals; D006801:Humans; D007107:Immune System; D051059:PTEN Phosphohydrolase; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010744:Phosphoric Monoester Hydrolases / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D025521:Tumor Suppressor Proteins
D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; C098706:INPPL1 protein, human; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases