title: Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists.
abstract: Several 1,3-diaminocyclopentane linked alpha1a-receptor antagonists were prepared using a divergent chemical strategy that allows for rapid analysis of all stereochemical permutations for their effect on alpha1-receptor binding.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Barrow
authors.forename: K L
authors.initials: KL
authors.lastname: Glass
authors.forename: H G
authors.initials: HG
authors.lastname: Selnick
authors.forename: R M
authors.initials: RM
authors.lastname: Freidinger
authors.forename: R S
authors.initials: RS
authors.lastname: Chang
authors.forename: S S
authors.initials: SS
authors.lastname: O'Malley
authors.forename: C
authors.initials: C
authors.lastname: Woyden
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D011744:Pyrimidinones; D018340:Receptors, Adrenergic, alpha-1