title: Phagocytic activity in familial Mediterranean fever.
abstract: Familial Mediterranean fever (FMF) is an autosomal recessive disease. Although the possibility of multiple immunologic mechanisms have been studied, the actual mechanism is still unresolved. Forty-one patients with FMF (24 males and 17 females with a mean age and disease duration of 17.8 +/- 4.1 and 4.7 +/- 2.3 years, respectively) and 14 healthy controls (10 males and 4 females with a mean age 23.2 +/- 5.1) were involved in the study. A phagotest was studied in both the patients and control groups with a FACScalibur Flow. All patients were in the acute stages of the disease and had not undergone colchicine treatment for 2 months. The percentage blood phagocytic activity of both granulocytes and monocytes were 84.23 +/- 8.76 and 67.28 +/- 10.15 in the patient group and 94.68 +/- 3.24 and 76.23 +/- 5.7 in the control group, respectively. There was no statistically significant difference in the percentage of phagocytic activity of the granulocytes and monocytes between the FMF patients and healthy controls (p > 0.05 and p > 0.05, respectively).
authors.affiliation: Department of Clinical Immunology and Rheumatology, SSK Ankara Ihtisas Hospital, Turkey. edc85@akbank.net.tr
authors.forename: G
authors.initials: G
authors.lastname: Keskin
authors.forename: A
authors.initials: A
authors.lastname: Inal
authors.forename: A
authors.initials: A
authors.lastname: Sengül
authors.forename: M
authors.initials: M
authors.lastname: Cindoruk
authors.forename: S
authors.initials: S
authors.lastname: Haznedaroğlu
authors.forename: M
authors.initials: M
authors.lastname: Duranay
authors.forename: Y
authors.initials: Y
authors.lastname: Songür
mesh_terms: D000293:Adolescent; D000328:Adult; D002634:Chemotaxis, Leukocyte; D010505:Familial Mediterranean Fever / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis