title: Dual role for Drosophila epidermal growth factor receptor signaling in early wing disc development.
abstract: Cell fate decisions in the early Drosophila wing disc assign cells to compartments (anterior or posterior and dorsal or ventral) and distinguish the future wing from the body wall (notum). Here we show that EGF-receptor (EGFR) signaling stimulated by its ligand, Vein, has a fundamental role in regulating two of these cell fate choices: (1) Vn/EGFR signaling directs cells to become notum by antagonizing wing development and by activating notum-specifying genes; (2) Vn/EGFR signaling directs cells to become part of the dorsal compartment by induction of apterous, the dorsal selector gene, and consequently also controls wing development, which depends on an interaction between dorsal and ventral cells.
authors.affiliation: Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Simcox
authors.forename: G
authors.initials: G
authors.lastname: Campbell
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D004330:Drosophila / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D029721:Drosophila Proteins; D066246:ErbB Receptors / Q000502:physiology*; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins; D019476:Insect Proteins / Q000235:genetics* / Q000378:metabolism; D060850:LIM-Homeodomain Proteins; D020880:Neuregulins; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014921:Wings, Animal / Q000254:growth & development*; D051155:Wnt1 Protein
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D060850:LIM-Homeodomain Proteins; D020880:Neuregulins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D051155:Wnt1 Protein; C074459:ap protein, Drosophila; C074622:wg protein, Drosophila; C102104:vn protein, Drosophila; D066246:ErbB Receptors