[Protein markers in evaluation of nephroprotective effects of antihypertensive drugs in patients with arterial hypertension].
Fifty patients with stable slight and moderate uncomplicated essential hypertension, treated by ramipril, atenolol, or isradipine, were examined. Total protein and urinary excretion of individual proteins were studied before and after treatment. Urinary concentrations of apolipoproteins A1 and B1, alpha 1-acid glycoprotein, alpha 1-antitrypsin, prealbumin, albumin, beta 2-microglobulin, transferrin, haptoglobin, IgG and IgA, and C3 and C4 complement components were measured. Index of proteinuria selectiveness was calculated for each portion of urine. All three drugs exerted a nephroprotective effect, atenolol being the most active of them. Apolipoproteins, IgG, and complement components were the most valuable for diagnosis. Their excretion correlated with the severity of arterial hypertension and efficiency of treatment. Use of protein markers helps reliably assess the renal function and monitor the treatment efficiency.
Rakov
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Betekhtina
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D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001053:Apolipoproteins / Q000652:urine*; D001262:Atenolol / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers; D003176:Complement C3 / Q000652:urine*; D003181:Complement C4 / Q000652:urine*; D005260:Female; D006242:Haptoglobins / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007074:Immunoglobulin G / Q000652:urine*; D007136:Immunoglobulins / Q000652:urine; D017275:Isradipine / Q000494:pharmacology / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D008991:Monitoring, Physiologic; D011228:Prealbumin / Q000652:urine; D011507:Proteinuria / Q000175:diagnosis*; D017257:Ramipril / Q000494:pharmacology / Q000627:therapeutic use; D014168:Transferrin / Q000652:urine
D000959:Antihypertensive Agents; D001053:Apolipoproteins; D015415:Biomarkers; D003176:Complement C3; D003181:Complement C4; D006242:Haptoglobins; D007074:Immunoglobulin G; D007136:Immunoglobulins; D011228:Prealbumin; D014168:Transferrin; D001262:Atenolol; D017257:Ramipril; D017275:Isradipine