New cytotoxic agents, BE-52440A and B, produced by a streptomycete.
New cytotoxic substances, designated BE-52440A and B, were isolated from the mycelium of Streptomyces sp. A52440. The active principles were extracted from the mycelium by methanol and purified by silica gel column chromatography. BE-52440A and B exhibited cytotoxic activity against murine and human tumor cell lines.
Tsukamoto
M
M
Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.
Nakajima
S
S
Murooka
K
K
Naito
M
M
Suzuki
H
H
Hirayama
M
M
Hirano
K
K
Kojiri
K
K
Suda
H
H
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002965:Classification; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; C414147:BE 52440 A; C414283:BE-52440B; D011714:Pyrans