The left ventricular ejection effect.
A recently developed model of the left ventricle, based on experimental data, has been shown to exhibit the main features of the heart's ability to pump. Two special cases during blood ejection, termed pressure deactivation and hyperactivation, were identified. This study proposes an 'ejection effect' correction to the model that addresses deactivation, hyperactivation and adjusts the shape of the computed ventricular ejection curve in late systole. Also, a new approach based on new animal experiments is proposed to identify the ejection effect mechanism(s).
Danielsen
M
M
Department of Mathematics and Physics, Roskilde University, Denmark.
Palladino
J L
JL
Mulier
J P
JP
Noordergraaf
A
A
D000818:Animals; D006801:Humans; D008433:Mathematics; D008955:Models, Cardiovascular; D013318:Stroke Volume / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology*; D017725:Ventricular Pressure / Q000502:physiology