Fetal target organs of graft-versus-host reaction induced in utero by injection of maternal cells in a pig model.
The target organs of graft-versus-host reaction (GVHR) in adult or neonates are the site of multifocal lymphocytic infiltrates. GVHR can also be acquired in utero by maternal cells crossing the placenta, but the fetal target organs are unknown. The aim of this study was to determine these target fetal organs. The distribution pathway of infused labeled lymphocytes within cryostat sections of fetal organs was analyzed, and fetal target organs of infused lymphocytes were investigated in both isogenic and semiallogenic situations. Isogenic cells were observed in less organs and semiallogenic cells were localized in a more restricted number of organs than isogenic cells. Furthermore, the liver, the thyroid, and the spleen were the fetal target organs in the two studied gestations. GALT, thymus, and kidney were also lymphocyte targets in isogenic gestation. In conclusion, isogenic cells induced GVHR in more fetal organs than semiallogenic cells.
Aboussaouira
T
T
Laboratoire d'Histologie-Embryologie II, Faculté de médicine 9, Vandouvre, Nancy, France. aboussaouira@fmp-uh2c.ac.ma
Salmon
H
H
Vanwalleghem
E
E
Gérard
H
H
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005315:Fetal Diseases / Q000276:immunology; D005333:Fetus / Q000276:immunology*; D006086:Graft vs Host Disease / Q000097:blood / Q000209:etiology* / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D023421:Models, Animal; D009035:Mothers; D009928:Organ Specificity / Q000276:immunology; D013552:Swine; D013997:Time Factors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous / Q000009:adverse effects; D014185:Transplantation, Isogeneic / Q000009:adverse effects; D014599:Uterus