Insulin-like growth factor-1 and breast cancer risk in postmenopausal African-American women.
We explored the relationship between insulin-like growth factor-1 (IGF-1) concentrations and breast cancer risk. Also, we examined whether obesity, sex hormone-binding globulin (SHBG), and estradiol influenced IGF-1 concentrations. A pilot study of 60 postmenopausal African-American women (30 cases and 30 controls) was used. Plasma concentrations of IGF-1 were higher among the cases, as compared to the controls. A negative trend was seen for plasma concentrations of IGF-1 and TNM (tumor-node-metastasis) stage and IGF-1 and body mass index. IGF-1 was found to be associated negatively with SHBG. After adjustment, plasma concentrations of IGF-1 remained significantly and positively associated with breast cancer risk (odds ratio, 1.183; 95% confidence interval, 1.167-1.201). No significant associations for breast cancer risk were observed for estradiol, SHBG, and body mass index. Further research with a larger sample is needed to clarify the relationships between obesity and IGF-1 concentrations to breast cancer risk in this population.
Agurs-Collins
T
T
Howard University Cancer Center, Division of Epidemiology and Cancer Control, Washington, DC 20012, USA.
Adams-Campbell
L L
LL
Kim
K S
KS
Cullen
K J
KJ
D000368:Aged; D000369:Aged, 80 and over; D044383:Black People; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D004958:Estradiol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D008875:Middle Aged; D009765:Obesity; D010865:Pilot Projects; D017698:Postmenopause; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000096:biosynthesis; D001741:Black or African American
D012738:Sex Hormone-Binding Globulin; D004958:Estradiol; D007334:Insulin-Like Growth Factor I