title: STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene.
abstract: The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. snel@embl-heidelberg.de
authors.forename: B
authors.initials: B
authors.lastname: Snel
authors.forename: G
authors.initials: G
authors.lastname: Lehmann
authors.forename: P
authors.initials: P
authors.lastname: Bork
authors.forename: M A
authors.initials: MA
authors.lastname: Huynen
mesh_terms: D005798:Genes, Bacterial / Q000502:physiology; D016247:Information Storage and Retrieval; D020407:Internet; D009174:Mycoplasma / Q000201:enzymology / Q000235:genetics; D009876:Operon; D012984:Software; D013379:Substrate Specificity; D012359:tRNA Methyltransferases / Q000378:metabolism
chemical_list: D012359:tRNA Methyltransferases