title: Synthesis and antimicrobial activity of squalamine analogue.
abstract: Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3beta-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine.
authors.affiliation: Department of Industrial Chemistry, Kyungpook National University, Taegu, South Korea. kimhs@knu.ac.kr
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: B S
authors.initials: BS
authors.lastname: Choi
authors.forename: K C
authors.initials: KC
authors.lastname: Kwon
authors.forename: S O
authors.initials: SO
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Kwak
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002777:Cholestanols / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013095:Spermidine / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D002777:Cholestanols; C079655:squalamine; D013095:Spermidine