[Olfactory testing with "sniffin' sticks" for clinical diagnosis of Parkinson disease].
Olfactory dysfunction seems to be one of the most frequent symptoms in idiopathic parkinsonian syndrome (IPS). In contrast to the increasing number of studies providing evidence of the usefulness of olfactory tests in the diagnosis of IPS, clinical assessment of olfactory function is rarely performed. This may be due to the lack of an easy-to-use, inexpensive, standardized, and reliable test. In this study, we administered the newly developed "sniffin' sticks" test to a group of 40 nondemented IPS patients and compared the results with 40 healthy controls matched for age, gender, and smoking habits. In all three subtests including odor identification, odor detection threshold, and odor discrimination, the control group scored significantly better than the IPS group, yielding a specificity and sensitivity of 90% each. Our results indicate that olfactory disturbances in IPS can be found at early stages of the disease, appear bilaterally, and do not correlate with the dominant side of parkinsonism. Therefore, we emphasize that olfactory testing may be a useful tool in the diagnosis of IPS.
Daum
R F
RF
Neurologische Klinik mit Poliklinik der Friedrich-Alexander-Universität Erlangen-Nürnberg.
Sekinger
B
B
Kobal
G
G
Lang
C J
CJ
D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D019937:Diagnostic Techniques and Procedures; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D000857:Olfaction Disorders / Q000175:diagnosis* / Q000209:etiology; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D012016:Reference Values; D012680:Sensitivity and Specificity; D012684:Sensory Thresholds; D012903:Smell