title: Hemolytic polar steroidal constituents of the starfish Aphelasterias japonica.
abstract: A reinvestigation of the polar steroid fraction from the starfish Aphelasterias japonica, collected near the Russian shore of the Sea of Japan, has afforded two new compounds, the disulfated quinovoside aphelasteroside C (1) and the monosulfated polyhydroxysteroid aphelaketotriol (2). Compounds 1 and 2 contain a unique 23-oxo-24-hydroxylated side chain that is unprecedented in marine steroids. The known compounds cheliferoside L1 (3), 3-O-sulfoasterone (4), forbeside E3 (5), and 3-O-sulfothornasterol A (6) were also isolated from this source. Compounds 1-3, 5, and 6 showed hemolytic activity to mouse erythrocytes.
authors.affiliation: Pacific Institute of Bioorganic Chemistry of the Far East Branch of the Russian Academy of Science, Vladivostok-22, Russian Federation.
authors.forename: N V
authors.initials: NV
authors.lastname: Ivanchina
authors.forename: A A
authors.initials: AA
authors.lastname: Kicha
authors.forename: A I
authors.initials: AI
authors.lastname: Kalinovsky
authors.forename: P S
authors.initials: PS
authors.lastname: Dmitrenok
authors.forename: V A
authors.initials: VA
authors.lastname: Stonik
authors.forename: R
authors.initials: R
authors.lastname: Riguera
authors.forename: C
authors.initials: C
authors.lastname: Jiménez
mesh_terms: D000818:Animals; D001681:Biological Assay; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D004912:Erythrocytes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009904:Optical Rotation; D012426:Russia; D012964:Sodium / Q000032:analysis; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013054:Spectrophotometry, Atomic; D013055:Spectrophotometry, Infrared; D013215:Starfish / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D013256:Steroids; C414468:aphelaketotriol; C414467:aphelasteroside C; D012964:Sodium