Palatable fluids do not affect alcohol intake and its reduction by serotonergic compounds in alcohol-preferring cAA rats.
1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) decreases alcohol intake by alcohol-preferring cAA rats more selectively than fluoxetine in a two-bottle alcohol vs. water paradigm. We report now that availability of sucrose or saccharin in a 3rd bottle does not affect (1) alcohol intake, supporting further the validity of this model of alcoholism, nor (2) the selectivity profile of the alcohol intake-reducing effects of these compounds. It is hypothesized that reduction of alcohol intake by DOI is not simply due to decreased intake of palatable fluids.
Maurel
S
S
CNS Research, Bayer AG, Aprather Weg 18 a, D-42096, Wuppertal, Germany.
Schreiber
R
R
De Vry
J
J
D000428:Alcohol Drinking / Q000503:physiopathology* / Q000517:prevention & control; D000437:Alcoholism / Q000503:physiopathology* / Q000517:prevention & control; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007215:Indophenol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013649:Taste
D017366:Serotonin Receptor Agonists; C113896:dimethoxy-4-indophenyl-2-aminopropane; D007215:Indophenol