title: Syntheses and biological evaluation of novel pseudomycin side-chain analogues. Part 2.
abstract: A series of aliphatic side-chain analogues of pseudomycin was synthesized and evaluated during the course of our side-chain SAR effort. We found that several of the pseudomycin side-chain analogues (e.g., 10) exhibited good in vitro activity against all three major fungi responsible for systemic fungal infections.
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. chen_shu-hui@lilly.com
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Sun
authors.forename: R
authors.initials: R
authors.lastname: Boyer
authors.forename: J
authors.initials: J
authors.lastname: Paschal
authors.forename: D
authors.initials: D
authors.lastname: Zeckner
authors.forename: W
authors.initials: W
authors.lastname: Current
authors.forename: M
authors.initials: M
authors.lastname: Zweifel
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011549:Pseudomonas / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D010456:Peptides, Cyclic; C107665:pseudomycin A