Substantia nigra pars reticulata lesion facilitates kainic acid-induced seizures.
The administration of subconvulsive doses of kainic acid (5 mg/kg, intraperitoneally) to rats, with lesion of the substantia nigra pars reticulata (1 week), produced high frequency wet dog shakes and severe convulsive behavior (observed in 60% of the rats). The behavior was not observed in rats treated with kainic acid but without reticulata lesion. The results show that rats with unilateral lesion of the substantia nigra pars reticulata are more vulnerable to seizure stimuli.
Fan
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XD
Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, S7N 5E4, Saskatchewan, Canada.
Li
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XM
Juorio
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AV
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000209:etiology*; D013378:Substantia Nigra / Q000187:drug effects / Q000293:injuries / Q000502:physiology*
D002316:Cardiotonic Agents; D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid; D004298:Dopamine