Interaction of poly methyl vinyl ether/maleic anhydride-dimiristoyl phosphatidylcholine: a model bioadhesion study.
The objective of this work is to study the interaction of a copolymer, poly methyl vinyl ether/maleic anhydride (PMV/MA) used in pharmaceutical dosage form and a phospholipid L-alpha-dimiristoyl phosphatidylcholine (DMPC) with the aim of developing a bioadhesive system. Glycerine is the plastifiant used to make PMV/MA insoluble. We have studied copolymer-plastifiant compatibility with differential scanning calorimetry and we have studied the influence that the solvents produce on the copolymer by infrared spectroscopy. Monolayer experiments were carried out with a Wilhelmy-type surface balance. The purpose of these experiments is to obtain molecular information about interaction PMV/MA-glycerine system with DMPC. The results show that there are attractive forces and it is a spontaneous process.
Nuñez
J L
JL
Departmento Fisicoquímica Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Ballesteros
M P
MP
Lastres
J L
JL
Castro
R M
RM
D000096:Acetone; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D004146:Dioxanes; D005990:Glycerol / Q000737:chemistry; D008298:Maleates / Q000737:chemistry*; D014677:Pharmaceutical Vehicles; D010713:Phosphatidylcholines / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011095:Polyethylenes / Q000737:chemistry*; D012997:Solvents; D013055:Spectrophotometry, Infrared
D003692:Delayed-Action Preparations; D004146:Dioxanes; D008298:Maleates; D014677:Pharmaceutical Vehicles; D010713:Phosphatidylcholines; D011091:Polyesters; D011095:Polyethylenes; D012997:Solvents; C419566:poly(methyl vinyl ether-maleic anhydride-dimyristoyl phosphatidylcholine); D000096:Acetone; C043105:poly(methyl vinyl ether-co-maleic anhydride); C025223:1,4-dioxane; D005990:Glycerol; D004134:Dimyristoylphosphatidylcholine