title: Conformational diffusion and helix formation kinetics.
abstract: The time, temperature, and sequence dependences of helix formation kinetics of fully atomistic peptide models in explicit solvent are described quantitatively by a diffusive search within the coil state with barrierless transitions into the helical state. Conformational diffusion leads to nonexponential kinetics and jump-width dependences in temperature jump experiments.
authors.affiliation: Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA. hummer@helix.nih.gov
authors.forename: G
authors.initials: G
authors.lastname: Hummer
authors.forename: A E
authors.initials: AE
authors.lastname: García
authors.forename: S
authors.initials: S
authors.lastname: Garde
mesh_terms: D007700:Kinetics; D008962:Models, Theoretical; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides