title: Intravenous nicardipine as a first-line antihypertensive drug in neonates.
abstract: OBJECTIVE
  Prospective recording of IV nicardipine efficacy and safety as a first-line antihypertensive drug in neonates.
  
  
  METHODS
  Twenty neonates (15 preterm) with systemic hypertension due to steroids administration (n = 14), polycystic kidney disease (n = 1), renal vein thrombosis (n = 1), coarctation of aorta (n = 1) or from an undetermined cause (n = 3).
  
  
  METHODS
  The initial nicardipine dosage was 0.5 microg/kg/min in 17 patients. The maximal nicardipine dosage was 0.74+/-0.41 microg/kg/ min (0.5-2.0). The duration of treatment was 14.6+/-11.6 days.
  
  
  RESULTS
  Systolic blood pressure significantly decreased after 3, 6, 12, 24 and 48 h of nicardipine treatment (-20+/-11%, -19+/-10%, -20+/-8%, -20+/-10% and -20+/-12%, respectively). The decrease in blood pressure remained significant over the subsequent days of treatment. No hypotension or other clinical side effects were observed.
  
  
  CONCLUSIONS
  Both additional pharmacokinetic and pharmacodynamic studies remain mandatory to improve the dosage regimens and assess the efficacy and safety of nicardipine infusion in hypertensive neonates.
authors.affiliation: Service de Pédiatrie 2, Hôpital d'Enfants, Dijon, France.
authors.forename: C
authors.initials: C
authors.lastname: Milou
authors.forename: V
authors.initials: V
authors.lastname: Debuche-Benouachkou
authors.forename: D S
authors.initials: DS
authors.lastname: Semama
authors.forename: J F
authors.initials: JF
authors.lastname: Germain
authors.forename: J B
authors.initials: JB
authors.lastname: Gouyon
mesh_terms: D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007231:Infant, Newborn; D007234:Infant, Premature; D007262:Infusions, Intravenous; D008297:Male; D009529:Nicardipine / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D009529:Nicardipine