[Chromatin nuclear proteins in evaluation of the effectiveness of treatment of patients with psoriasis].
Histone proteins and nucleic acid precursors were studied in 10 normal subjects and 20 patients with disseminated psoriasis before and after combined therapy including Enkad. A drop in the concentrations of H1 histones was detected in the blood lymphocytes and plasma in parallel with an increase in the concentrations of arginine-rich histones and a many-fold decrease in the acid-soluble fraction representing a pool of nucleic acid precursors. After combined therapy the ratio of lysin- and arginine-rich nuclear proteins in blood lymphocytes changed significantly and approximated the normal value; the distribution of histone-like proteins virtually did not change in the plasma, but the level of plasma and erythrocyte acid-soluble fraction normalized. This indicates positive changes in nucleic acid transport after therapy. The authors demonstrate the possibility of these findings for evaluation of the treatment efficiency.
Markusheva
L I
LI
Savina
M I
MI
Reshina
V M
VM
Toguzov
R T
RT
D000293:Adolescent; D000328:Adult; D002843:Chromatin / Q000378:metabolism*; D004247:DNA / Q000032:analysis; D004912:Erythrocytes / Q000378:metabolism; D006657:Histones / Q000097:blood*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D009696:Nucleic Acids / Q000097:blood / Q000378:metabolism; D011701:PUVA Therapy; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D013053:Spectrophotometry
D002843:Chromatin; D006657:Histones; D009696:Nucleic Acids; D004247:DNA