title: Oxidative stress resistance: a robust correlated response to selection in extended longevity lines of Drosophila melanogaster?
abstract: Stress resistance is associated with longevity in Drosophila melanogaster and other model organisms used for genetic research. The present study tests for oxidative stress resistance in one set of lines selected for late-life reproduction and extended longevity. Both females and males from the selected lines were appreciably more resistant to oxidative stress than were flies from the control lines. A relative increase in oxidative stress resistance is a correlated response to selection in this laboratory selection experiment. Increased oxidative stress resistance appears to be a relatively robust correlated response to laboratory selection for late-life reproduction and extended longevity.
authors.affiliation: School of Biological Sciences, University of Nebraska-Lincoln, 68588, USA. lharsh@unlserve.unl.edu
authors.forename: L G
authors.initials: LG
authors.lastname: Harshman
authors.forename: B A
authors.initials: BA
authors.lastname: Haberer
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D004331:Drosophila melanogaster; D005260:Female; D006540:Herbicides / Q000009:adverse effects; D008136:Longevity / Q000187:drug effects / Q000235:genetics; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D010269:Paraquat / Q000009:adverse effects; D012098:Reproduction / Q000235:genetics; D012641:Selection, Genetic; D015996:Survival Rate; D014867:Water
chemical_list: D006540:Herbicides; D014867:Water; D010269:Paraquat