Platelet monoamine oxidase activity during surgical intervention under condition of hypothermic perfusion.
Platelet and plasma monoamine oxidase activity was determined at early stages of hypothermic perfusion and circulatory arrest. Monoamine oxidase activity decreased more drastically and restored more slowly against the background of deep (14 degrees C) compared to moderate hypothermia (26-29 degrees C). The decrease in platelet monoamine oxidase activity was accompanied by its increase in the plasma, which attests to mechanical (in tubes) and toxic damage to platelets. The latter is associated with increased partial O(2) pressure in the plasma during hypothermia, which promotes the formation of reactive oxygen species.
Korotkina
R N
RN
A. V. Vishnevski Institute of Surgery, Research Center of Surgery, Russian Academy of Medical Sciences.
Rudneva
V G
VG
Zatsepina
N E
NE
Lokshin
L S
LS
Smirnov
L S
LS
Karelin
A A
AA
D000328:Adult; D015415:Biomarkers; D001792:Blood Platelets / Q000201:enzymology*; D005112:Extracorporeal Circulation; D006801:Humans; D007036:Hypothermia, Induced; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D015415:Biomarkers; D017382:Reactive Oxygen Species; D008995:Monoamine Oxidase