title: The effect of hormone replacement therapy on arterial distensibility and compliance in perimenopausal women: a 2-year randomised trial.
abstract: A single centre randomised placebo-controlled trial was performed to assess the 2-year effects of hormone replacement therapy compared to placebo on mechanical arterial properties in 99 perimenopausal women recruited from the general population. The trial was double-blind with respect to a sequential combined regimen of oral 17beta-oestradiol and desogestrel (17betaE(2)-D) and the placebo group and open with respect to combination of conjugated equine oestrogens and norgestrel (CEE-N). At baseline, distensibility and compliance of the common carotid artery were measured non-invasively with B-mode ultrasound and a vessel wall movement detector system, and the distensibility coefficient (DC) and compliance coefficient (CC) were calculated. Measurements were repeated after 6 and 24 months. Change in DC and CC in treatment groups was compared to placebo. After 24 months, changes for 17betaE(2)-D compared to placebo were -1.4x10(-3)/kPa (95% CI -4.4; 1.7, P=0.39) for DC and 0. 26 mm(2)/kPa (95% CI -0.01; 0.53, P=0.07) for CC. Changes for CEE-N compared to placebo were 0.4x10(-3)/kPa (95% CI -1.0; 1.9, P=0.79) and 0.11 mm(2)/kPa (95% CI -0.14; 0.37, P=0.40). For systolic blood pressure (SBP), diastolic blood pressure (DBP) and arterial lumen diameter no changes were found. In this study no significant differences in changes in distensibility and compliance were found between perimenopausal women using 17betaE(2)-D or CEE-N and women using placebo after 6 and 24 months.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical School, Erasmus University, POB 1738, 3000 DR, Rotterdam, The Netherlands.
authors.forename: I C
authors.initials: IC
authors.lastname: Westendorp
authors.forename: M J
authors.initials: MJ
authors.lastname: de Kleijn
authors.forename: M L
authors.initials: ML
authors.lastname: Bots
authors.forename: A A
authors.initials: AA
authors.lastname: Bak
authors.forename: J
authors.initials: J
authors.lastname: Planellas
authors.forename: H J
authors.initials: HJ
authors.lastname: Coelingh Bennink
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: D E
authors.initials: DE
authors.lastname: Grobbee
authors.forename: J C
authors.initials: JC
authors.lastname: Witteman
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000517:prevention & control; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D003187:Compliance / Q000187:drug effects; D016001:Confidence Intervals; D017135:Desogestrel / Q000008:administration & dosage*; D004311:Double-Blind Method; D004548:Elasticity / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D011336:Probability; D012016:Reference Values; D016896:Treatment Outcome; D014463:Ultrasonography; D014654:Vascular Patency / Q000187:drug effects* / Q000502:physiology
chemical_list: D004958:Estradiol; D017135:Desogestrel