Enantioselective copper-catalyzed conjugate addition of dialkyl zinc to nitro-olefins
[reaction: see text]The copper-catalyzed asymmetric conjugate addition of dialkylzinc onto various nitro-olefins has been carried out with excellent results. An enantiomeric excess of up to 94% was obtained using 0.5% Cu(OTf)2 and 1% of chiral trivalent phosphorus ligand.
Alexakis
A
Department of Organic Chemistry, University of Geneva, Switzerland. alexandre.alexakis@chiorg.unige.ch
Benhaim
C