Renal Doppler sonographic and histologic findings in post-transplant primary cytomegalovirus disease.
Cytomegalovirus (CMV) infections frequently develop in renal transplant patients. The transplanted kidney may be not only the source of infection but also the target for it. We report a case of primary CMV infection in a seronegative patient who received a graft from a seropositive cadaveric donor. The onset of CMV was clinically apparent on post-transplant day 22. Interestingly, soon after transplantation, the patient developed a long-lasting graft dysfunction episode for which diffuse endothelial-cell swelling was the most relevant finding at biopsy. On sonography, renal graft vascular impedance deteriorated and improved repeatedly during the follow-up period. We postulate that the patient had CMV-induced immunogenic-mediated endothelial-cell injury.
Salgado
O J
OJ
Center for Experimental Surgery, University of Zulia, Apartado Postal 1430, Maracaibo 4001-A, Venezuela.
Henríquez
C
C
Rosales
B
B
Martín
M G
MG
García
R
R
Rodríguez-Iturbe
B
B
D000328:Adult; D001707:Biopsy, Needle; D003586:Cytomegalovirus Infections / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000008:administration & dosage; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
D015774:Ganciclovir