Glycoprotein degradation: do sugars hold the key?
Secretory glycoproteins that fail to fold or assemble correctly are retained in the endoplasmic reticulum and eventually degraded. Recent evidence shows that trimming of their N-linked oligosaccharide chains plays a key role in targeting glycoproteins for destruction.
Frigerio
L
L
Department of Biological Sciences, University of Warwick, CV4 7AL, Coventry, UK.
Lord
J M
JM
D002135:Calcium-Binding Proteins / Q000378:metabolism; D037281:Calnexin; D037282:Calreticulin; D004721:Endoplasmic Reticulum / Q000201:enzymology* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006023:Glycoproteins / Q000378:metabolism*; D006031:Glycosylation; D007212:Indolizines / Q000494:pharmacology; D008361:Mannosidases / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D009844:Oligosaccharides / Q000378:metabolism*; D017510:Protein Folding; D011499:Protein Processing, Post-Translational; D012261:Ribonucleoproteins / Q000378:metabolism; D054836:Indolizidines
D002135:Calcium-Binding Proteins; D037281:Calnexin; D037282:Calreticulin; D004791:Enzyme Inhibitors; D006023:Glycoproteins; D007212:Indolizines; D008361:Mannosidases; D018832:Molecular Chaperones; D009844:Oligosaccharides; D012261:Ribonucleoproteins; C037806:castanospermine; D054836:Indolizidines