title: Experimental models of Reye's syndrome.
abstract: Intraperitoneal administration of 4-pentenoic acid (20 mg/kg/day for seven days or ten doses of 50 mg/kg with 4 h intervals) or acetylsalicylic acid (50 mg/kg 1 hour after single pyrogenal injection) to rats reproduced metabolic disorders characteristic of Reye's syndrome: hyperenzymemia, hyperbilirubinemia, decreased levels of ketone bodies and urea, hypoglycemia, hypoproteinemia, accumulation of ammonia and phenol, and acidosis. Necroses and microvesicular steatosis were found in the liver.
authors.affiliation: Department of Pharmacology, Medico-Biological Faculty, Siberian Medical University, Tomsk.
authors.forename: A S
authors.initials: AS
authors.lastname: Saratikov
authors.forename: A I
authors.initials: AI
authors.lastname: Vengerovskii
authors.forename: A G
authors.initials: AG
authors.lastname: Arbuzov
authors.forename: V S
authors.initials: VS
authors.lastname: Chuchalin
authors.forename: M B
authors.initials: MB
authors.lastname: Chervyakova
authors.forename: I V
authors.initials: IV
authors.lastname: Sukhodolo
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D051381:Rats; D012202:Reye Syndrome