A paradoxical idea of cancer's resolution.
Polykaryocytes arising by means of fusion represent genetic deadlock. They cannot enter the S-phase of mitosis and they die quickly. A concept of cancer treatment proposes the conversion of tumor cells synchronously into the stage of unviable polykaryocytes, which leads to dissociation of the tumor substrate, reduction of the mass of tumor, and even to its resolution. Under echoscopic control, it is proposed to introduce into the tumor a solution ofwell-known fusogenic agents, such as polyethylene glycol (PEG) with the 15% dimethylsulfoxide (DMSO).
Gogichadze
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GK
Institute of Hematology and Blood Transfusion, Tbilisi, Georgia.
Gedenidze
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AV
D002459:Cell Fusion; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D011092:Polyethylene Glycols / Q000494:pharmacology
D011092:Polyethylene Glycols; D004121:Dimethyl Sulfoxide