title: Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality.
abstract: Biochemical and genetic data suggest that the Apoa2c allele of the apolipoprotein A-II gene causes severe senile amyloidosis (AApoAII) in SAMP1, a mouse model for accelerated senescence. We analyzed the effects of replacement of Apoa2c in SAMP1 mice with non-amyloidogenic Apoa2b on amyloidosis, lipoprotein metabolism, and progression of senescence using a congenic strain, P1.R1-Apoa2b, which has the Apoa2b chromosome region of SAMR1 in the genome of SAMP1. Age-associated amyloid deposition was not observed, but plasma concentrations of apoA-II protein and HDL-cholesterol decreased with age in P1.R1-Apoa2b. P1.R1-Apoa2b showed lower scores of senescence than did SAMP1. However, the life span and mortality rate doubling time were similar in P1.R1-Apoa2b and SAMP1. These results suggest that replacement of Apoa2c with non-amyloidogenic Apoa2b does not rescue SAMP1 mice from a short life span and accelerated mortality.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Matsushita
authors.forename: K
authors.initials: K
authors.lastname: Kogishi
authors.forename: C
authors.initials: C
authors.lastname: Xia
authors.forename: A
authors.initials: A
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Chiba
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Hosokawa
authors.forename: K
authors.initials: K
authors.lastname: Higuchi
mesh_terms: D000375:Aging / Q000235:genetics*; D000483:Alleles; D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000235:genetics; D000704:Analysis of Variance; D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood / Q000235:genetics; D016633:Apolipoprotein A-II / Q000097:blood / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood / Q000378:metabolism; D003643:Death; D004195:Disease Models, Animal; D005260:Female; D008136:Longevity / Q000235:genetics*; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D000685:Serum Amyloid A Protein / Q000235:genetics; D015996:Survival Rate; D013997:Time Factors
chemical_list: D000682:Amyloid; D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D008076:Cholesterol, HDL; D000685:Serum Amyloid A Protein