Effects of 17 beta-estradiol and its isomer 17 alpha-estradiol on learning in rats with chronic cholinergic deficiency in the brain.
It was shown for the first time that estrogens 17 beta- and 17 alpha-estradiols compensate impaired cognitive functions in rats with partial chronic deprivation of cholinergic functions in the central nervous system induced by intracerebral administration of selective cholinergic neurotoxin AF64A. 17 beta-Estradiol produced strong dose-dependent changes in the weights of hormone-sensitive endocrine glands, while 17 alpha-estradiol did not affect the weight of the gonads and slightly influenced (in high concentration) the weights of the adrenal glands and thymus. The positive effects of exogenous 17 beta- and 17 alpha-estradiols on cognitive functions are due to their antioxidant properties, rather than due to specific action on hormone-sensitive endocrine glands.
Lermontova
N N
NN
Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow region.
P'chev
V K
VK
Beznosko
B K
BK
Van'kin
G I
GI
Ivanova
T A
TA
Koroleva
I V
IV
Lukoyanova
E A
EA
Mukhina
T V
TV
Serkova
T P
TP
Bachurin
S O
SO
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D004958:Estradiol / Q000494:pharmacology* / Q000502:physiology; D007858:Learning; D020033:Protein Isoforms / Q000494:pharmacology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011950:Receptors, Cholinergic / Q000502:physiology*
D020033:Protein Isoforms; D011950:Receptors, Cholinergic; D004958:Estradiol