title: Gastric emptying of solids: estimates of lag phase and constant emptying times.
abstract: There is no consensus regarding the best way to estimate the lag phase time (Tlag) and the constant emptying time (TRE) of the gastric emptying of solids. Furthermore, biphasic gastric emptying is usually described by the modified power exponential function of either Elashoff or Siegel. In an attempt to test the validity of the power exponential functions and to identify relevant parameters of biphasic gastric emptying, we followed an approach which consists of describing the power exponential function by two straight lines. The first line is horizontal and represents Tlag. The second line is tangential to the constant emptying [tangent at the maximum slope (MS) or at the half-emptying value]. Scintigraphic data of 132 patients and 15 controls were fitted by both power exponential functions. Each corresponding half-emptying time, Tlag and TRE estimated from the Elashof and Siegel power exponential functions were strongly correlated (0.93 < r < 1, P < 0.0001). The Bland and Altman statistical method demonstrated good agreement (<5% outliers). The half-emptying tangent method sometimes gave negative Tlag and should be abandoned. Tlag(MS) and TRE(MS) did not correlate and therefore were independent parameters. We conclude that the Elashoff and Siegel functions are equivalent and that the maximum slope tangent method allows a reliable description of the two independent phases of gastric emptying.
authors.affiliation: Department of Nuclear Medicine, Hôtel Dieu, University of Nantes, France. ocouturier70@hotmail.com
authors.forename: O
authors.initials: O
authors.lastname: Couturier
authors.forename: C
authors.initials: C
authors.lastname: Le Rest
authors.forename: J
authors.initials: J
authors.lastname: Gournay
authors.forename: M
authors.initials: M
authors.lastname: Pourdehnad
authors.forename: B
authors.initials: B
authors.lastname: Bridji
authors.forename: A
authors.initials: A
authors.lastname: Turzo
authors.forename: Y
authors.initials: Y
authors.lastname: Bizais
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013270:Stomach / Q000000981:diagnostic imaging; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D019275:Radiopharmaceuticals; D013671:Technetium Tc 99m Sulfur Colloid