Genetics of heart development.
The genes that drive heart-cell differentiation in vertebrates and Drosophila are similar, even though the Drosophila 'heart' is a simple tube and the vertebrate heart is a multichambered physiologically complex organ. Mutational analysis in mice and, as particular focus of this review, in zebrafish, reveals the additional genes brought into play to fashion these evolutionarily 'new' organotypic components.
Chen
J N
JN
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA. chenjn@mcdb.ucla.edu
Fishman
M C
MC
D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning; D006321:Heart / Q000196:embryology* / Q000502:physiology; D051379:Mice; D009024:Morphogenesis