[Effect of somatotropic hormone on insulin secretion in pups].
The effects of the administration of bovine somatotropic hormone (bSTH) in pups were investigated. The daily profile after a dose of bSTH injected subcutaneously showed an increase in serum immunoreactive insulin (IRI) with serum glucose levels within the normal range. Free fatty acids were also elevated. After a second bSTH administration, the response to an intravenous glucose load caused marked elevation of serum IRI while serum glucose remained similar to control values. The results are compatible with a response resembling that of adult dogs submitted to similar bSTH administration of short duration. The hyperinsulinemia thus induced may be a key factor in maintenance of normoglycemia.
Pierluissi
J
J
Laboratorio de Diabetología, Escuela de Medicina José María Vargas, Universidad Central de Venezuela, Caracas, Venezuela.
Maksimenko
A
A
Quero
Z
Z
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology; D013006:Growth Hormone / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013006:Growth Hormone; D005947:Glucose