Serotonin and pancreatic duct function.
1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
Naruse
S
S
Internal Medicine II, Nagoya University School of Medicine, Japan. snaruse@med.nagoya-u.ac.jp
Suzuki
A
A
Ishiguro
H
H
Kitagawa
M
M
Ko
S B
SB
Yoshikawa
T
T
Yamamoto
A
A
Hamada
H
H
Hayakawa
T
T
D008735:5-Methoxytryptamine / Q000494:pharmacology; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006168:Guinea Pigs; D010183:Pancreatic Ducts / Q000187:drug effects / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology; D012701:Serotonin / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D012633:Secretin; D012701:Serotonin; D008735:5-Methoxytryptamine; C045918:2-methyl-5-HT; D000109:Acetylcholine; D002118:Calcium