title: Cochlear ischemia induced by circulating iron particles under magnetic control: an animal model for sudden hearing loss.
abstract: OBJECTIVE
  To correlate the absence of distortion-product otoacoustic emissions observed in sudden hearing loss (SHL) with a possible thromboembolic vascular cause, using an animal model.
  
  
  BACKGROUND
  Distortion-product otoacoustic emissions (DPOAEs) are sensitive to cochlear disorders and are absent in cochlear injury. In a previous study, the authors showed that 75% of patients with SHL who have no measurable emissions do not recover hearing. The underlying cause of the loss of emissions is unknown, but it may be secondary to cochlear ischemia.
  
  
  METHODS
  Six New Zealand white rabbits underwent unilateral cochlear embolization through the use of circulating iron particles under magnetic control. Cochlear function was monitored through DPOAE recordings of the experimental and control ears.
  
  
  RESULTS
  In all animals, a rapid decrease in emissions was noted, which fluctuated but returned to baseline within 2 hours to 3 weeks after embolization, leaving no measurable residual defects. The DPOAEs were suppressed by 5 to 19 dB within 10 minutes of injection of iron solution and magnet placement. The lowest emissions were obtained at 30 minutes and again at 120 minutes, which were 12 to 37 dB below preembolization levels. Two animals returned to baseline DPOAE levels at 1 to 3 weeks, with no identifiable residual deficits.
  
  
  CONCLUSIONS
  It is likely that the loss of emissions seen in the present study is related to cochlear ischemia. The early suppression of DPOAEs in the rabbit cochlea after embolization may parallel that in SHL patients with absence of DPOAEs on presentation.
authors.affiliation: Albany Medical College, New York, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Schweinfurth
authors.forename: A T
authors.initials: AT
authors.lastname: Cacace
mesh_terms: D000818:Animals; D003051:Cochlea / Q000098:blood supply* / Q000378:metabolism*; D004195:Disease Models, Animal; D003639:Hearing Loss, Sudden / Q000209:etiology*; D007501:Iron / Q000493:pharmacokinetics*; D007511:Ischemia / Q000150:complications* / Q000378:metabolism*; D008280:Magnetics; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D011817:Rabbits; D013997:Time Factors
chemical_list: D007501:Iron