title: Advances in nutritional management of chronic pancreatitis.
abstract: Nutrition has an important role in the management of chronic pancreatitis (CP), with two main goals for treatment of patients. The first goal is to provide optimal nutrition support and the second is to decrease pain by minimizing stimulation of the exocrine pancreas. Because cholecystokinin (CCK) stimulates secretion from the exocrine pancreas, one approach is to decrease CCK levels through modulation of diet. If postprandial pain is a limiting factor, alternative enteral therapies that minimally stimulate the pancreas may be beneficial. Nutritional counseling, antioxidants, and pancreatic enzymes may play a role in effective management of CP as well. In addition, because idiopathic CP is associated with cystic fibrosis gene mutations, therapies directed toward cystic fibrosis may also benefit these patients.
authors.affiliation: Harvard Medical School, Beth Israel Deaconess Medical Center, Dana 501, 330 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Shea
authors.forename: I K
authors.initials: IK
authors.lastname: Hopper
authors.forename: P G
authors.initials: PG
authors.lastname: Blanco
authors.forename: S D
authors.initials: SD
authors.lastname: Freedman
mesh_terms: D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000150:complications / Q000235:genetics; D004750:Enteral Nutrition; D005227:Fatty Acids / Q000502:physiology; D005526:Food, Formulated; D006801:Humans; D018529:Nutritional Support; D009842:Oligopeptides / Q000627:therapeutic use; D010195:Pancreatitis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*
chemical_list: D005227:Fatty Acids; D009842:Oligopeptides; C073248:Peptamen