[Phospholipid content in "late" posttraumatic epileptic focus in rabbits].
The phospholipids content in the cortex, hippocamp and stem tissues in rabbits with "late" posttraumatic epileptic focus (1 year after the light brain injury) was estimated. There was established an increase of the content of phosphatidylethanolamine, sphingomyeline, phosphatidylinosite, phosphatidic acid, non-identified phospholipids, decrease of the content of phosphatidylcholine and cardiolipine and appearance of lysophosphatidylcholine in the cortical epileptic focus tissues. The conclusion is made that the changes within the phospholipids pool may cause the epileptogenic disturbance in the neurons, i.e. the changes of functional properties of the excitable membranes and the activity of the mytochondrial phospholipid-dependent enzyme complex.
Cherchenko
A P
AP
Institute of Neurosurgery AMS, Kyiv, Ukraine.
Sautin
Iu Iu
IuIu
D000818:Animals; D001930:Brain Injuries / Q000150:complications*; D004827:Epilepsy / Q000209:etiology / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits
D010743:Phospholipids