Effects of heavy and deuterium-depleted water on vascular reactivity.
The comparative study of heavy and deuterium-depleted water on the vascular reactivity has shown significant changes of the basal tone in the smooth muscle of the rat thoracic aorta rings. While the heavy water induced relaxing effects, the deuterium-depleted water increased basal tone and vasoconstrictor responses at phenylephrin, noradrenalin and angiotensin. Endothelial nitric oxide seems to be involved in generating the muscular relaxing effects of heavy water.
Haulică
I
I
Department of Physiology, University of Medicine and Pharmacy Iaşi.
Peculea
M
M
Stefănescu
I
I
Tiţescu
G
G
Todiraş
M
M
Bild
W
W
D000809:Angiotensins / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology; D017666:Deuterium Oxide / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014666:Vasomotor System / Q000187:drug effects*; D014867:Water / Q000494:pharmacology*
D000809:Angiotensins; D004791:Enzyme Inhibitors; D014662:Vasoconstrictor Agents; D014867:Water; D010656:Phenylephrine; D017666:Deuterium Oxide; D019331:NG-Nitroarginine Methyl Ester; D009638:Norepinephrine