Positive atrial inotropic effect of dofetilide after cardioversion of atrial fibrillation or flutter.
The pure class III agent dofetilide was evaluated to determine its effect on atrial function after cardioversion of atrial fibrillation or flutter. Compared with placebo, dofetilide-treated patients had evidence of better atrial function after cardioversion, indicating that this agent has a positive atrial inotropic effect during the period of postcardioversion atrial stunning.
DeCara
J M
JM
Boston Medical Center, Massachusetts 02118, USA.
Pollak
A
A
Dubrey
S
S
Falk
R H
RH
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D001282:Atrial Flutter / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D001783:Blood Flow Velocity / Q000187:drug effects; D004311:Double-Blind Method; D018618:Echocardiography, Doppler, Color; D004554:Electric Countershock; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D010627:Phenethylamines / Q000627:therapeutic use*; D026902:Potassium Channel Blockers; D012008:Recurrence; D013318:Stroke Volume / Q000187:drug effects; D013449:Sulfonamides / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D010627:Phenethylamines; D026902:Potassium Channel Blockers; D013449:Sulfonamides; C063533:dofetilide