Kidney development: regulatory molecules crucial to both mice and men.
Although the study of embryonic kidney development began in the 1950s, three decades passed until scientists began identifying the molecular controls of renal organogenesis. Most of these advances have come from mouse gene targeting and rodent kidney explant manipulation. Translation of the rodent data to human congenital kidney disease has only just begun. The activities of those regulatory molecules proven to be used in common appear remarkably similar in mouse and human renal development. Examples of these genes include glial cell line-derived neurotrophic factor (GDNF), RET, PAX2, Wilms tumor suppressor (WT1), and components in the renin-angiotensin pathway. Other factors that participate in mouse renal organogenesis, such as N-Myc, may later be proven important in human kidney development.
Bates
C M
CM
Children's Research Institute, Children's Hospital, Columbus, Ohio 43205, USA. batesc@pediatrics.ohio-state.edu
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D005314:Embryonic and Fetal Development / Q000235:genetics; D016162:Genes, Wilms Tumor; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D006801:Humans; D007668:Kidney / Q000196:embryology* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D051762:PAX2 Transcription Factor; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C495039:GDNF protein, human; C495040:Gdnf protein, mouse; D051100:Glial Cell Line-Derived Neurotrophic Factor; D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D051762:PAX2 Transcription Factor; C497318:PAX2 protein, human; C497319:Pax2 protein, mouse; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila; C494999:Ret protein, mouse