title: Neuromuscular ataxia: a new spontaneous mutation in the mouse.
abstract: Neuromuscular ataxia, nma, is a new autosomal recessive mutation that arose spontaneously in CBA/J inbred mice at The Jackson Laboratory. The mutation, now maintained on the B6C3FeF(1) hybrid background, when homozygous, causes small size, uncoordinated gait, dysmetria, dystonia, general weakness, and death shortly after weaning. No biochemical or morphological abnormalities have been detected. We used an intercross between the B6C3FeF(1) mutant and CAST/Ei to map the nma mutation to the proximal end of Chr 12. The most likely gene order places the mutation between D12Mit270 and D12Mit54, non-recombinant with D12Mit2 in 96 tested meioses.
authors.affiliation: The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. pwb@jax.org
authors.forename: P F
authors.initials: PF
authors.lastname: Ward-Bailey
authors.forename: B
authors.initials: B
authors.lastname: Wood
authors.forename: K R
authors.initials: KR
authors.lastname: Johnson
authors.forename: R T
authors.initials: RT
authors.lastname: Bronson
authors.forename: L R
authors.initials: LR
authors.lastname: Donahue
authors.forename: M T
authors.initials: MT
authors.lastname: Davisson
mesh_terms: D000818:Animals; D001259:Ataxia / Q000235:genetics*; D015152:Blotting, Northern; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002875:Chromosomes; D004247:DNA / Q000032:analysis; D006579:Heterozygote; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D009154:Mutation; D009468:Neuromuscular Diseases / Q000235:genetics*; D010641:Phenotype
chemical_list: D004247:DNA