title: [Degradation of 4,9-dichlorodibenzodioxin in rat liver microsomes].
abstract: The rat liver microsomal cytochrome P 450 was established to dechlorinate 4,9-dichlorodibenzodioxin into 4,9-dihydroxydibenzodioxin. Two isoforms of this cytochrome P 450 were electrophoreticaly identified and quantified. 4,9-dihydroxidibenzodioxin transforms into resorcin with the help of ascorbic acid.
authors.affiliation: I. I. Mechnikov Odessa State University. inna@farlep.net
authors.forename: V V
authors.initials: VV
authors.lastname: Sumbaev
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004147:Dioxins / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D012118:Resorcinols / Q000378:metabolism
chemical_list: D004147:Dioxins; D012118:Resorcinols; C000925:2,7-dichlorodibenzo-4-dioxin; D003577:Cytochrome P-450 Enzyme System; D001205:Ascorbic Acid; C031389:resorcinol