title: Antifeedant activity of withanolides from Salpichroa origanifolia on Musca domestica.
abstract: The antifeedant effect of several salpichrolides on larvae of Musca domestica was investigated. Three naturally occurring compounds, salpichrolide A (1), salpichrolide C (2), and salpichrolide G (3), previously isolated from Salpichroa origanifolia, and two known (4, 6) and three new (5, 7, 8) synthetic analogues were tested. The maximal effect on development was observed for salpichrolide A (1), while salpichrolide G (3) was the most toxic. The content of the salpichrolides in S. origanifolia was monitored by HPLC during plant development, reaching a maximum during summer.
authors.affiliation: Cátedra de Zoología Agrícola, Facultad de Agronomía, Universidad de Buenos Aires, Avda San Martín 4453 (1417) Buenos Aires, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Mareggiani
authors.forename: M I
authors.initials: MI
authors.lastname: Picollo
authors.forename: E
authors.initials: E
authors.lastname: Zerba
authors.forename: G
authors.initials: G
authors.lastname: Burton
authors.forename: M C
authors.initials: MC
authors.lastname: Tettamanzi
authors.forename: M O
authors.initials: MO
authors.lastname: Benedetti-Doctorovich
authors.forename: A S
authors.initials: AS
authors.lastname: Veleiro
mesh_terms: D000818:Animals; D001118:Argentina; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D004175:Diptera; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D012621:Seasons; D019657:Solanaceae / Q000737:chemistry*
chemical_list: D007306:Insecticides; D004875:Ergosterol