title: Patent foramen ovale and its embolic implications.
abstract: This study investigates the usefulness of the echocardiographic characteristics of patent foramen ovale (PFO) in the stratification of stroke recurrence risk in patients with acute ischemic cerebral disease. Shunting at rest and a highly mobile fossa ovalis membrane are more frequently detected in stroke patients with PFO as the only identifiable cause of embolism. For PFO patients with both rest patency and membrane mobility > 6.5 mm, the risk of stroke/transient ischemic attack recurrence was 7.6% (95% CI, 0-18.0) at 12 months and 12.5% (95% CI, 0-26.1) at 24 months (p = 0.05). The association of both rest patency and high membrane mobility seems to identify those stroke patients with PFO at higher risk for further brain embolism.
authors.affiliation: Department of Clinical Medicine, La Sapienza University of Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: De Castro
authors.forename: D
authors.initials: D
authors.lastname: Cartoni
authors.forename: M
authors.initials: M
authors.lastname: Fiorelli
authors.forename: M
authors.initials: M
authors.lastname: Rasura
authors.forename: S
authors.initials: S
authors.lastname: Beni
authors.forename: C
authors.initials: C
authors.lastname: Urani
authors.forename: F
authors.initials: F
authors.lastname: Papetti
authors.forename: F
authors.initials: F
authors.lastname: Fedele
mesh_terms: D016022:Case-Control Studies; D017548:Echocardiography, Transesophageal; D005500:Follow-Up Studies; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D020766:Intracranial Embolism / Q000000981:diagnostic imaging* / Q000209:etiology*; D012008:Recurrence; D012306:Risk