title: Bing de ling, a Chinese herbal formula, stimulates multifaceted immunologic responses in mice.
abstract: Bing de ling is a Chinese herbal formula most commonly used in complementary medical settings against viral disorders. We have found that bing de ling potentiates upregulation of immune activity when administered to mice in dosages proportional to those used clinically. These mice demonstrated significant elevation of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production in splenocytes and enhancement of macrophage, natural killer cell, and lymphokine-activated killer cell cytotoxicity. These data are consistent with bing de ling's clinically observed efficacy against viruses and identify the formula as a promising candidate for clinical trials against diverse diseases that may respond to increased immunologic activity.
authors.affiliation: Immunology Program, H. Lee Moffitt Cancer Center & Research Institute, Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, USA.
authors.forename: G
authors.initials: G
authors.lastname: Niu
authors.forename: J
authors.initials: J
authors.lastname: Tan
authors.forename: J G
authors.initials: JG
authors.lastname: Turner
authors.forename: J G
authors.initials: JG
authors.lastname: Brabham
authors.forename: L G
authors.initials: LG
authors.lastname: Burdelya
authors.forename: B E
authors.initials: BE
authors.lastname: Crucian
authors.forename: H
authors.initials: H
authors.lastname: Wall-Apelt
authors.forename: R J
authors.initials: RJ
authors.lastname: Zhao
authors.forename: H
authors.initials: H
authors.lastname: Yu
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects; D007694:Killer Cells, Natural / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D007371:Interferon-gamma