title: Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1.
abstract: We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin side-chain analogues without compromising in vitro antifungal activity.
authors.affiliation: Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
authors.forename: J
authors.initials: J
authors.lastname: Jamison
authors.forename: S
authors.initials: S
authors.lastname: Levy
authors.forename: X
authors.initials: X
authors.lastname: Sun
authors.forename: D
authors.initials: D
authors.lastname: Zeckner
authors.forename: W
authors.initials: W
authors.lastname: Current
authors.forename: M
authors.initials: M
authors.lastname: Zweifel
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez
authors.forename: W
authors.initials: W
authors.lastname: Turner
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011549:Pseudomonas / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D010456:Peptides, Cyclic; C107665:pseudomycin A