An antitumor pectic polysaccharide from Feronia limonia.
An acidic heteropolysaccharide has been isolated from the tropical angiosperm Feronia limonia syn. F. elephantum (family: Rutaceae). A partially carboxymethylated alpha-(1-4) polygalacturonan backbone structure with 2- and 2,4-O-alpha-L-rhamnopyranosyl, 2- and 2, 3-O-alpha-L-arabinofuranosyl and 3-, 2,4-and terminal alpha-D-galactopyranosyl bearing side chains has been tentatively assigned. The preliminary study in the murine model showed some significant in vivo Ehrlich ascites carcinoma cell growth inhibition.
Saima
Y
Y
Department of Chemistry, Indian Institute of Chemical Biology (IICB), 700032, Calcutta, India.
Das
A K
AK
Sarkar
K K
KK
Sen
A K
AK
Sur
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P
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019685:Rosales / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D011134:Polysaccharides