Therapeutic effect of gypenoside on chronic liver injury and fibrosis induced by CCl4 in rats.
Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities.
Chen
J C
JC
Research Institute of Chinese Medicine, Chinese Medical College, Taichung, Taiwan.
Tsai
C C
CC
Chen
L D
LD
Chen
H H
HH
Wang
W C
WC
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000517:prevention & control*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D011042:Poisons / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000627:therapeutic use*
D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; D011042:Poisons; D012503:Saponins; C077955:gypenoside IX; D002251:Carbon Tetrachloride