title: [Transdermal administration of drugs by electroporation].
abstract: Short high-voltage pulses have been shown to increase, accelerate and broaden transdermal drug delivery to molecules of variable physicochemical properties, i.e., from 18 to 38,000 Da, hydro- and lipophilic, neutral and charged molecules, via a mechanism hypothesized to involve electroporation of the stratum corneum lipid bilayers. Transport is increased by up to 4 orders of magnitude, and onset times for significant transport reduce from hours by passive diffusion to a few minutes.
authors.affiliation: Unité de Pharmacie galénique, industrielle et officinale, Ecole de Pharmacie, Faculté de Médecine, U.C.L., Bruxelles.
authors.forename: R
authors.initials: R
authors.lastname: Vanbever
mesh_terms: D000279:Administration, Cutaneous; D004058:Diffusion; D018274:Electroporation / Q000379:methods*; D006801:Humans; D010539:Permeability; D012869:Skin Absorption; D013997:Time Factors