title: Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (Celastraceae).
abstract: Ten sesquiterpenoids (1-10), with a dihydro-beta-agarofuran skeleton, were isolated from Maytenus cuzcoina (Celastraceae). Their structures were elucidated on the basis of spectral analysis, including homo- and heteronuclear correlations NMR experiments (COSY, ROESY, HMQC and HMBC), and chemical correlations. The compounds have been tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. Compounds 1-3, 6 and 7 showed strong inhibitory effects on EBV-EA induction (100% inhibition at 1000 mol ratio/TPA). Their structure-activity relationship is discussed.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: A G
authors.initials: AG
authors.lastname: González
authors.forename: B M
authors.initials: BM
authors.lastname: Tincusi
authors.forename: I L
authors.initials: IL
authors.lastname: Bazzocchi
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: T
authors.initials: T
authors.lastname: Konoshima
authors.forename: I A
authors.initials: IA
authors.lastname: Jiménez
authors.forename: A G
authors.initials: AG
authors.lastname: Ravelo
mesh_terms: D000956:Antigens, Viral / Q000187:drug effects / Q000378:metabolism; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D013053:Spectrophotometry; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000956:Antigens, Viral; D000970:Antineoplastic Agents; C033305:Epstein-Barr virus early antigen; D012717:Sesquiterpenes; D013755:Tetradecanoylphorbol Acetate