The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region.
EmrR negatively regulates the transcription of the multidrug resistance pump-encoding operon, emrRAB, by binding to its regulatory region. The binding site spans the promoter and the downstream sequence up to the transcriptional start site of the operon. Structurally unrelated drugs that induce the pump interfere with this binding.
Xiong
A
A
Department of Microbiology and Immunology, Stanford University School of Medicine, Sherman Fairchild D317, Stanford, California 94305, USA.
Gottman
A
A
Park
C
C
Baetens
M
M
Pandza
S
S
Matin
A
A
D001426:Bacterial Proteins / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects*; D005798:Genes, Bacterial / Q000187:drug effects* / Q000235:genetics; D009876:Operon / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000187:drug effects* / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid / Q000187:drug effects / Q000235:genetics; D012097:Repressor Proteins / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014157:Transcription Factors
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C093326:mprA protein, E coli