title: Diabetes as a result of atypical anti-psychotic drugs--a report of three cases.
abstract: OBJECTIVE
  Atypical anti-psychotic drugs (APDs) are widely used in psychotic disorders refractory to conventional neuroleptic agents.
  
  
  RESULTS
  Three cases of new-onset diabetes are reported in Caucasian men who were on clozapine (one) or olanzapine (two) for 3-6 months. They had a distinct presentation: weight loss, ketosis (one ketoacidosis), severe hyperglycaemia requiring insulin therapy, and relative insulin deficiency as reflected by glucagon stimulatory tests. In all cases, insulin was stopped within 1 month after the APD was discontinued.
  
  
  CONCLUSIONS
  Novel APDs not only induce diabetes as a result of weight gain in predisposed patients, but can also lead to a reversible state of insulin deficiency, and sometimes ketoacidosis.
authors.affiliation: Service de Nutrition-Diabétologie, Hôpital Haut-Lévêque, Pessac, France.
authors.forename: V
authors.initials: V
authors.lastname: Rigalleau
authors.forename: B
authors.initials: B
authors.lastname: Gatta
authors.forename: S
authors.initials: S
authors.lastname: Bonnaud
authors.forename: M
authors.initials: M
authors.lastname: Masson
authors.forename: M L
authors.initials: ML
authors.lastname: Bourgeois
authors.forename: V
authors.initials: V
authors.lastname: Vergnot
authors.forename: H
authors.initials: H
authors.lastname: Gin
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D003024:Clozapine / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy; D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects / Q000031:analogs & derivatives*; D011618:Psychotic Disorders / Q000188:drug therapy*; D012559:Schizophrenia / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D007004:Hypoglycemic Agents; D007328:Insulin; D001569:Benzodiazepines; D010890:Pirenzepine; D003024:Clozapine; D000077152:Olanzapine; D005905:Glyburide