Poloxamers and poloxamines in nanoparticle engineering and experimental medicine.
Poloxamers and poloxamine nonionic surfactants have diverse applications in various biomedical fields ranging from drug delivery and medical imaging to management of vascular diseases and disorders. Although this is a progressive, rapidly advancing field in biotechnology, the future will depend on the recognition and rectification of a range of toxicity issues, which have to be addressed but have frequently been ignored until now.
Moghimi
S M
SM
The Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, Cockcroft Building, University of Brighton, BN2 4GJ., Brighton, UK. s.m.moghimi@brighton.ac.uk
Hunter
A C
AC
D000276:Adjuvants, Immunologic / Q000737:chemistry; D000818:Animals; D001187:Artificial Organs; D001672:Biocompatible Materials; D001698:Biomedical Engineering; D002462:Cell Membrane; D003167:Complement Activation; D004337:Drug Carriers; D018432:Drug Resistance, Multiple; D005029:Ethylenediamines; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D010587:Phagocytosis; D011060:Poloxalene / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D013154:Spleen / Q000378:metabolism
D000276:Adjuvants, Immunologic; D001672:Biocompatible Materials; D004337:Drug Carriers; D005029:Ethylenediamines; D020442:Poloxamer; D011060:Poloxalene