title: TMC-135A and B, new triene-ansamycins, produced by Streptomyces sp.
authors.affiliation: Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda-shi, Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishio
authors.forename: J
authors.initials: J
authors.lastname: Kohno
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: S I
authors.initials: SI
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Kawano
authors.forename: S
authors.initials: S
authors.lastname: Komatsubara
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D017828:Rifabutin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; C414188:TMC-135A; C414187:TMC-135B; D017828:Rifabutin