title: Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii.
abstract: The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.
authors.affiliation: Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
authors.forename: W
authors.initials: W
authors.lastname: He
authors.forename: M
authors.initials: M
authors.lastname: Cik
authors.forename: A
authors.initials: A
authors.lastname: Lesage
authors.forename: I
authors.initials: I
authors.lastname: Van der Linden
authors.forename: N
authors.initials: N
authors.lastname: De Kimpe
authors.forename: G
authors.initials: G
authors.lastname: Appendino
authors.forename: J
authors.initials: J
authors.lastname: Bracke
authors.forename: S G
authors.initials: SG
authors.lastname: Mathenge
authors.forename: F P
authors.initials: FP
authors.lastname: Mudida
authors.forename: J E
authors.initials: JE
authors.lastname: Leysen
authors.forename: L
authors.initials: L
authors.lastname: Van Puyvelde
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D004224:Diterpenes; D004952:Esters; D019665:Euphorbiaceae / Q000737:chemistry*; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects*; D013057:Spectrum Analysis; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004224:Diterpenes; D004952:Esters; D013729:Terpenes; D014315:Triterpenes; C417923:kirkinine; C011309:mezerein