[The functional-morphological characteristics of alcohol-induced pathology as dependent on the nature of the intoxication and its nootropil correction in an experiment].
The response of hematological system, carbohydrate metabolism and pathomorphologic alterations in the viscera were studied for four weeks on the model of chronic alcoholization in conditions of hydrolytic alcohol production. It is shown that maximal deviations of all the parameters in white conventional rats occur after receiving a combined ethanol dose in inhalation of a mixture of methanol and furfurol vapour. Less manifest pathology was revealed in simultaneous introduction of nootropil solution. Thus, functional-morphologic changes in alcoholic intoxication in unfavourable environment are reversible in purposeful application of drugs with neurometabolic effect.
Sidorov
P I
PI
Gromova
L E
LE
Solov'ev
A G
AG
Degteva
G N
GN
Leont'ev
V Ia
VIa
Savastenko
A E
AE
D000437:Alcoholism / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D021461:Animals, Outbred Strains; D001769:Blood / Q000187:drug effects; D001773:Blood Cells / Q000187:drug effects; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005662:Furaldehyde / Q000633:toxicity; D008297:Male; D000432:Methanol / Q000633:toxicity; D018697:Nootropic Agents / Q000627:therapeutic use*; D010889:Piracetam / Q000627:therapeutic use*; D051381:Rats
D018697:Nootropic Agents; D005662:Furaldehyde; D000432:Methanol; D010889:Piracetam