Evaluation of bone formation in fetal skeletons following prenatal paracetamol administration in single alizarin-stained specimens in Wistar rats.
The study was undertaken to evaluate the effect of paracetamol on skeleton in Wistar rats. The drug was administered orally, once a day, in three doses: P1--3.5 mg/kg, P2--35.0 mg/kg, P3--350.0 mg/kg. The foetuses were delivered by laparotomy on the 21st day of pregnancy and fixed in alcohol. The skeletons were stained with alizarin. Insignificant differences of bone malformations were found.
Burdan
F
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Human Anatomy Department, Medical University School of Lublin, Poland. frank@tkt.net.pl
D000014:Abnormalities, Drug-Induced; D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D000818:Animals; D000880:Anthraquinones; D001846:Bone Development / Q000187:drug effects; D001842:Bone and Bones / Q000002:abnormalities*; D005260:Female; D008297:Male; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013194:Staining and Labeling
D018712:Analgesics, Non-Narcotic; D000880:Anthraquinones; D000082:Acetaminophen; C010078:alizarin