title: Analysis of the effect of asymptomatic carotid atherosclerosis study on the outcome and volume of carotid endarterectomy.
abstract: Recent studies have demonstrated the benefits of carotid endarterectomy (CEA) and risk factor control in preventing stroke in asymptomatic patients. In this study, the effect of the asymptomatic carotid atherosclerosis study (ACAS) on the frequency of CEAs performed and the outcome of such procedures on symptomatic and asymptomatic patients were analyzed. From 1990 to 1996, all patients undergoing CEA were prospectively entered into a computerized vascular registry. The number of procedures, indications, demographics, and early and late results were analyzed and compared with similar data compiled prior to the ACAS study. The total volume of CEAs performed increased from 66 in 1990 to 719 in 1996 (ratio 1:12.3). The ratio of symptomatic to asymptomatic patients changed from 1.75:1 in 1990 to 1:1.52 in 1996. The combined stroke/mortality rate dropped from 4.75% in 1990 to 2.15% in 1996. The stroke mortality in the asymptomatic group decreased significantly from 4.3 to 1.9% in the pre and post-ACAS groups respectively (P<0.0005). The stroke mortality of symptomatic patients remained constant at 2.1 and 1.4% respectively.Since the completion of ACAS in 1993, the number of CEAs performed on our service has increased tenfold. An increase in volume has translated into an improved stroke/mortality rate and significantly decreased length of stay.
authors.affiliation: Institute for Vascular Health and Disease, Albany Medical College, NY, Albany 12208, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Darling
authors.forename: P B
authors.initials: PB
authors.lastname: Kreienberg
authors.forename: S P
authors.initials: SP
authors.lastname: Roddy
authors.forename: P S
authors.initials: PS
authors.lastname: Paty
authors.forename: B B
authors.initials: BB
authors.lastname: Chang
authors.forename: W E
authors.initials: WE
authors.lastname: Lloyd
authors.forename: D M
authors.initials: DM
authors.lastname: Shah
mesh_terms: D001161:Arteriosclerosis / Q000150:complications / Q000601:surgery*; D016893:Carotid Stenosis / Q000150:complications / Q000601:surgery*; D016894:Endarterectomy, Carotid / Q000706:statistics & numerical data*; D006801:Humans; D007902:Length of Stay; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012042:Registries; D012307:Risk Factors; D020521:Stroke / Q000209:etiology / Q000401:mortality / Q000517:prevention & control