Enhancement of vasoconstrictor responses to 5-HT but no to methoxamine by cooling in isolated dog lingual and mesenteric arteries.
The effect of temperature on submaximal vasoconstrictions to an intraluminal injection of serotonin (5-HT) and methoxamine was investigated in isolated and perfused canine lingual and mesenteric arteries, using the cannula insertion method. In both arteries cooling (from 37 degrees C to 27 degrees C) caused a remarkable enhancement of vasoconstriction to 5-HT, but did not to methoxamine. In lingual arteries, methoxamine-induced constrictions were strongly depressed, although those were slightly depressed in mesenteric arteries. It is assumed that 5-HT produces an important role to modulate vascular tonicity in low temperature conditions.
Tsukada
M
M
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Chiba
S
S
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001833:Body Temperature Regulation; D003080:Cold Temperature; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D017538:Mesenteric Artery, Superior / Q000187:drug effects; D008729:Methoxamine / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D014059:Tongue / Q000098:blood supply; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D014662:Vasoconstrictor Agents; D012701:Serotonin; D008729:Methoxamine