Gremlins, glomeruli and diabetic nephropathy.
There have been major advances in our understanding of the pathogenetic mechanisms of diabetic nephropathy in recent years. Of particular interest is the emerging paradigm of the role that developmentally important genes may play in this process, representing recapitulation of the ontogenic process. This review examines the potential pathophysiological involvement of one such developmental gene gremlin in diabetic nephropathy.
Lappin
D W
DW
Department of Medicine and Therapeutics, The Conway Institute of Biomolecular and Biomedical Research, University College Dublin and Mater Misericordiae Hospital, Ireland.
Hensey
C
C
McMahon
R
R
Godson
C
C
Brady
H R
HR
D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007678:Kidney Glomerulus; D011506:Proteins / Q000235:genetics* / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; C486399:GREM1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins