Anti-Candida activity of a new platinum derivative.
A new platinum derivative of the form H[Pt(IV)(Hdigly)Cl(2)(OH)(2)] (Hdigly==glycylglycine) damaged the Candida albicans cell membrane and inhibited the growth of the cells. The cytotoxic activity of H[Pt(IV)(Hdigly)Cl(2)(OH)(2)] on mammalian cells was 10-fold lower than that of cis-diammine-dichloroplatinum (cisplatin). Substitution of platinum for peptides is effective for enhancement of antifungal activity and reduction of the toxicity to mammalian cells.
Watanabe
T
T
Department of Microbiology, Tohoku Pharmaceutical University, Sendai 981-8558, Japan.
Takano
M
M
Ogasawara
A
A
Mikami
T
T
Kobayashi
T
T
Watabe
M
M
Matsumoto
T
T
D000935:Antifungal Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C415965:dichlorodihydroxo(glycylglycine)platinate(IV); D002945:Cisplatin