title: Reactivity of HeLa tumoral cells under the in vitro action of some aromatic compounds from the phytomass.
abstract: The in vitro action of some natural polyphenolic preparations, extracted from the leaves of Asclepias syriaca, upon the proteinosynthesis of HeLa cancerous cells and, implicitly, upon the development of HeLa cells cultures was investigated. The significant perturbation of proteic biogenesis, the inhibition of HeLa tumoral cells cultures development, as well as the existence of a dose--response relationship argue the behaviour of these products as in vitro active cytostatic agents. This characterization justifies their introduction in the in vivo screening program on rats bearing of different experimental tumoral lines, for the preclinical pharmacological evaluation of the POLYAS I and POLYAS II vegetable polyphenols antineoplastic activity.
authors.affiliation: Institute of Biological Research, Jassy, Romania.
authors.forename: P
authors.initials: P
authors.lastname: Rotinberg
authors.forename: V
authors.initials: V
authors.lastname: Nuţă
authors.forename: S
authors.initials: S
authors.lastname: Kelemen
authors.forename: D
authors.initials: D
authors.lastname: Petraşincu
authors.forename: H
authors.initials: H
authors.lastname: Rotinberg
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D010636:Phenols / Q000032:analysis* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D010636:Phenols; D011500:Protein Synthesis Inhibitors