title: Plasma homocysteine is a predictor of alcohol withdrawal seizures.
abstract: An adaptive consequence of prolonged ethanol consumption is a compensatory up-regulation of NMDA receptors in certain brain areas. Taking into account that homocysteine and its breakdown products (i.e. homocysteic acid) are putative neurotransmitters and agonists at the NMDA receptor, the aim of this study was to assess the influence of levels of homocysteine on alcohol withdrawal seizures. Six patients with chronic alcoholism who suffered from withdrawal seizures had significantly higher levels of homocysteine on admission (84.7 +/- 29.8 micromol/l) than patients (n = 26) who did not develop seizures (30.2 +/- 23.2 micromol/l; U = 8.0, p = 0.0007). Furthermore, seizure patients had significantly lower levels of folate and significantly higher blood alcohol concentrations. Using a logistic regression analysis, withdrawal seizures were best predicted by a high homocysteine level on admission (p < 0.01; odds ratio = 1.05). Homocysteine levels on admission may be a useful screening method to identify patients at risk for withdrawal seizures.
authors.affiliation: Department of Psychiatry, Georg-August-University of Göttingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Bleich
authors.forename: D
authors.initials: D
authors.lastname: Degner
authors.forename: B
authors.initials: B
authors.lastname: Bandelow
authors.forename: N
authors.initials: N
authors.lastname: von Ahsen
authors.forename: E
authors.initials: E
authors.lastname: Rüther
authors.forename: J
authors.initials: J
authors.lastname: Kornhuber
mesh_terms: D000328:Adult; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D005260:Female; D005492:Folic Acid / Q000097:blood; D005544:Forecasting; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012640:Seizures / Q000097:blood / Q000139:chemically induced*; D013375:Substance Withdrawal Syndrome / Q000150:complications*
chemical_list: D006710:Homocysteine; D000431:Ethanol; D005492:Folic Acid