First total synthesis of dragmacidin A via indolylglycines.
The first total synthesis of dragmacidin A has been accomplished using condensation of two indolylglycines followed by cyclization and reduction. The general and practical method for synthesis of indolylglycines via Wittig reaction, azide addition, and reduction from indolin-3-ones is also described.
Kawasaki
T
T
Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588 Japan. kawasaki@my-pharm.ac.jp
Enoki
H
H
Matsumura
K
K
Ohyama
M
M
Inagawa
M
M
Sakamoto
M
M
D000818:Animals; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010879:Piperazines / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry
D007211:Indoles; D010879:Piperazines; C414902:dragmacidin A; D005998:Glycine