A rat experimental model for the design of vaccines against tumor associated antigens Tn and Sialyl-Tn.
Clones either strongly or barely expressing the Tn and Sialyl-Tn antigens were isolated from a rat colon carcinoma cell line. Expression of the antigens in normal rat tissues was very restricted and vaccination using Ovine Submaxillary Mucin as the immunogen could delay growth of the Sialyl-Tn positive cells, but not of the Sialyl-Tn negative cells in syngeneic rats. The model should be useful for testing new anti-Tn or Sialyl-Tn vaccination protocols.
Hallouin
F
F
INSERM U419, Institut de Biologie, Nantes, France.
Goupille
C
C
Rocher
J
J
Le Pendu
J
J
D000818:Animals; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000096:biosynthesis* / Q000276:immunology; D019976:Cloning, Organism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D051379:Mice; D008954:Models, Biological; D009077:Mucins / Q000276:immunology; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000378:metabolism; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured; D014611:Vaccination
D015295:Antigens, Tumor-Associated, Carbohydrate; D009077:Mucins; C040286:Tn antigen; C055491:sialosyl-Tn antigen