Phosphatidylserine reverses reserpine-induced amnesia.
The effects of phosphatidylserine (PS) were studied in rats treated with reserpine (1 mg/kg) immediately after training in the passive avoidance task. In experiment I, phosphatidylserine (25 mg/kg) was administered 30 min before or immediately after training. Acute pre- or post-treatment with phosphatidylserine was effective in reversing the amnestic effect of reserpine in test trials performed 24 h and 1 week after training. Experiment II was performed to determine if the long-term pretreatment with phosphatidylserine (25 mg/kg) for 7 days is able to protect the rats against the amnestic effects of reserpine in this task. The data show that phosphatidylserine reverses the impairment induced by reserpine in trials performed 24 h and 1 week after training. These results indicate that the memory deficits associated with catecholamine depletion caused by reserpine can be attenuated by acute pre- or post-training or by long-term pretreatment with this phospholipid.
Alves
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CS
Laboratorio de Fisiologia e Farmacologia do SNC-Centro Politecnico, Department of Pharmacology, Federal University of Paraná, Jardim das Americas--PR, Caixa Postal 19.031, CEP 81.531-990, Curitiba, Brazil.
Andreatini
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R
da Cunha
C
C
Tufik
S
S
Vital
M A
MA
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects; D008297:Male; D010718:Phosphatidylserines / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine
D014150:Antipsychotic Agents; D010718:Phosphatidylserines; D012110:Reserpine