title: Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids.
abstract: Novel (+/-)-4-azolyl retinoic acid analogues 4, 5, 7 and 8 have been designed and synthesized and have been shown to be powerful inhibitors of hamster microsomal all-trans-retinoic acid 4-hydroxylase enzyme(s). (+/-)-4-(1H-Imidazol-1-yl)retinoic acid (4) is the most potent inhibitor of this enzyme reported to date.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore 21021-1559, USA. vnjar001@umaryland.edu
authors.forename: V C
authors.initials: VC
authors.lastname: Njar
authors.forename: I P
authors.initials: IP
authors.lastname: Nnane
authors.forename: A M
authors.initials: AM
authors.lastname: Brodie
mesh_terms: D000818:Animals; D001393:Azoles / Q000494:pharmacology*; D006224:Cricetinae; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D000072516:Retinoic Acid 4-Hydroxylase; D012176:Retinoids / Q000494:pharmacology*; D014212:Tretinoin / Q000378:metabolism
chemical_list: D001393:Azoles; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D012176:Retinoids; D014212:Tretinoin; D003577:Cytochrome P-450 Enzyme System; D000072516:Retinoic Acid 4-Hydroxylase