Chloroquine poisoning: report of two cases.
Two patients intentionally took chloroquine in overdose for different purposes. The first patient took chloroquine 2.7 g to terminate her pregnancy and the second patient took 3.75 g to terminate his life. The management of these two patients mainly consisted of gastric lavage, activated charcoal, ventilation, diazepam and inotropic support. The effect of chloroquine on the myocardium is discussed and the role of chloroquine as an abortifacient is reviewed. Hypokalemia should be recognized early and treated cautiously to avoid hyperkalemia. Refractory seizures not responding to benzodiazepine may require an antiepileptic drug.
Reddy
V G
VG
Department of Anaesthesia and ICU, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman. gowri@omantel.net.om
Sinna
S
S
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D000931:Antidotes / Q000627:therapeutic use; D000962:Antimalarials / Q000506:poisoning*; D002606:Charcoal; D002738:Chloroquine / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced; D003975:Diazepam / Q000627:therapeutic use; D062787:Drug Overdose; D005260:Female; D005751:Gastric Lavage; D006321:Heart / Q000187:drug effects; D006801:Humans; D011247:Pregnancy; D012640:Seizures / Q000139:chemically induced; D013406:Suicide, Attempted
D000927:Anticonvulsants; D000931:Antidotes; D000962:Antimalarials; D002606:Charcoal; D002738:Chloroquine; D003975:Diazepam