title: The EEG consistency index as a measure of ADHD and responsiveness to medication.
abstract: The primary diagnostic procedure for Attention-Deficit/Hyperactivity Disorder (ADHD) is the clinical interview, because psychological, neuropsychological, and neurological tests to date have not had sufficient specificity. Currently, there is no objective means to measure severity of ADHD, or the extent to which it is benefited by various dosages of medication. We recently reported that a certain EEG profile, the Consistency Index, occurring during the transition between two easy cognitive tasks clearly differentiated ADHD from non-ADHD boys between the ages of 8 and 12. The current study replicated this with older males (19-25) using different tasks, and a double blind, placebo versus Ritalin controlled crossover design. Seven ADHD subjects were found to have a significantly lower Consistency Index than 6 non-ADHD males while transitioning from 2 Simple tasks during placebo condition, while only the ADHD subjects demonstrated a significant improvement in their Consistency Index while on Ritalin. Similar but nonsignificant trends were observed while transitioning across Hard tasks.
authors.affiliation: Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Merkel
authors.forename: D J
authors.initials: DJ
authors.lastname: Cox
authors.forename: B
authors.initials: B
authors.lastname: Kovatchev
authors.forename: J
authors.initials: J
authors.lastname: Morris
authors.forename: R
authors.initials: R
authors.lastname: Seward
authors.forename: R
authors.initials: R
authors.lastname: Hill
authors.forename: R
authors.initials: R
authors.lastname: Reeve
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000145:classification / Q000188:drug therapy* / Q000503:physiopathology*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D003071:Cognition; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004569:Electroencephalography; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage / Q000494:pharmacology*; D015203:Reproducibility of Results
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate