title: Natural product derived inhibitors of lipoprotein associated phospholipase A2, synthesis and activity of analogues of SB-253514.
abstract: The synthesis of analogues of SB-253514, a novel natural product derived inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), is described together with their ability to inhibit Lp-PLA2.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK. ivan_pinto-l@sbphrd.com
authors.forename: I L
authors.initials: IL
authors.lastname: Pinto
authors.forename: H F
authors.initials: HF
authors.lastname: Boyd
authors.forename: D M
authors.initials: DM
authors.lastname: Hickey
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D011714:Pyrans; C414127:SB 253514; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase