title: Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers.
abstract: To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed LOH at one or more loci. The peak LOH frequency was identified at D21S1820 (34.2%) in 21q22.3. This data suggests that this locus might harbor a new tumor suppressor gene in an area <0.332 Mb in physical map distance defined by D21S1820 and D21S49. Thus, we speculate that trefoil factor family 1 (TFF1), located in this narrow region, might be the most probable candidate gene involved in gastric cancer carcinogenesis.
authors.affiliation: Department of Pathology and Genetic Oncology Laboratory, College of Medicine, The Catholic University of Korea, 137-701, Seoul, South Korea.
authors.forename: W S
authors.initials: WS
authors.lastname: Park
authors.forename: R R
authors.initials: RR
authors.lastname: Oh
authors.forename: J Y
authors.initials: JY
authors.lastname: Park
authors.forename: N J
authors.initials: NJ
authors.lastname: Yoo
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: M S
authors.initials: MS
authors.lastname: Shin
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: W G
authors.initials: WG
authors.lastname: An
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm