Characterization of 1,2-benzo-8-(2-aminoethyl)-3-phenoxazone.
The compound 1,2-benzo-8-(2-aminoethyl)-3-phenoxazone (1) is synthesized by reacting tyramine with 1-nitroso-2-naphthol in the presence of nitric acid. During the reaction, tyramine and 1-nitroso-2-naphthol undergo condensation, ring closure, and subsequent oxidation steps to form 1. Compound 1 is characterized by one- and two-dimensional NMR spectroscopy and mass spectrometry. The proposed mechanism of reaction is based on the spectroscopic data. This reaction can be applied as a spot test analysis for analogous phenolic compounds.
Bhansali
K G
KG
College of Pharmacy and Health Sciences, Texas Southern University, Houston 77004, USA.
Kook
A M
AM
D009682:Magnetic Resonance Spectroscopy; D009603:Nitroso Compounds; D010078:Oxazines / Q000138:chemical synthesis / Q000737:chemistry*; D014439:Tyramine
C414048:1,2-benzo-8-(2-aminoethyl)-3-phenoxazone; D009603:Nitroso Compounds; D010078:Oxazines; C020456:phenoxazinone; C025341:1-nitroso-2-naphthol; D014439:Tyramine