Modulation of bone remodeling by active vitamin D: its role in the treatment of osteoporosis.
Active vitamin D drugs are used for the treatment of osteoporosis in a number of countries, including Japan. However, their use is controversial. Here, we briefly discuss two issues that are important for understanding the role of active vitamin D (rather than plain vitamin D) in the treatment of osteoporosis: (1) whether or not its skeletal effects are mediated solely through its effects on intestinal calcium absorption in calcium- and vitamin D-replete states, and (2) how it modulates the bone remodeling process.
Ikeda
K
K
Department of Geriatric Research, National Institute for Longevity Sciences, 36-3 Gengo, Morioka, Obu, 474-8522, Aichi, Japan. kikeda@nils.go.jp
Ogata
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E
D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D001862:Bone Resorption / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D004703:Endocrine System / Q000378:metabolism; D004967:Estrogens; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010024:Osteoporosis / Q000188:drug therapy*; D010281:Parathyroid Hormone / Q000378:metabolism; D010641:Phenotype; D014807:Vitamin D / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use
D004967:Estrogens; D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium