Chromatin-immune connections: regulation of MHC and other genes.
In cells, genes are contained within chromatin - a highly structured array of DNA wrapped around core histone proteins. Packaged genes are subject to a variety of regulatory modifications including, CpG methylation, histone acetylation and phosphorylation. These epigenetic mechanisms of gene regulation involve higher ordered protein complexes possessing enzymatic activities such as ATP hydrolysis and acetylation that are targeted to specific genes by transcription factors, coactivatorsand coreptessors. In this article, we endeavor to providean overview of current research on mechanisms of transcriptional regulation by chromatin remodeling of MHC and other genes that are of interest in reproductive immunology.
Magner
W J
WJ
Department of Immunology, Roswell Park Cancer Institute, 14263, Buffalo, NY, USA.
Tomasi
T B
TB
D000818:Animals; D002843:Chromatin / Q000502:physiology*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D008285:Major Histocompatibility Complex
D002843:Chromatin