Association of HLA-DRB1*1602 and DRB1*1001 with Takayasu arteritis in Colombian mestizos as markers of Amerindian ancestry.
We performed HLA Class I and Class II typing in 16 patients (15 women, one man) with a confirmed diagnosis of Takayasu arteritis. We did not find any of the previously described associations with HLA-B52, and/or HLA-DRB1*1301 alleles. However, in our patients, HLA-DRB1*1602 and HLA-DRB1*1001 were significantly increased. The association of Takayasu arteritis with Amerindian and Asian HLA-DRB1 alleles (DRB1*1602 and DRB1*1001) in the Colombian mestizo patients reported here, and with HLA-B*3906 previously reported in Mexicans, suggest the possibility that some HLA and disease associations are markers for ethnicity of a population carrying a disease gene which is present in an admixed population with the disease.
Salazar
M
M
Corporation CorpoGen., Santafé de Bogotá, Bogotá, Colombia. gmarcela@openway.com.co
Varela
A
A
Ramirez
L A
LA
Uribe
O
O
Vasquez
G
G
Egea
E
E
Yunis
E J
EJ
Iglesias-Gamarra
A
A
D000293:Adolescent; D000328:Adult; D000483:Alleles; D003105:Colombia; D005260:Female; D006684:HLA-DR Antigens; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013625:Takayasu Arteritis / Q000208:ethnology* / Q000235:genetics*
D006684:HLA-DR Antigens