A rapid procedure to prepare cefotaxime.
A rapid procedure is reported for the synthesis of cefotaxime, by acylation of the 7-amino cephalosporanic acid with the 2-mercaptobenzothiazolyl thioester of (Z)-2-[2-aminothiazol-4-yl]-2-methoxyimino acetic acid (MAEM) that is a commercial reagent. The reaction was carried out at room temperature for 1 h, obtaining 95% yield. 2-Mercaptobenzothiazole was recovered as a side-product with a high purity and yield. The proposed method differentiates from those reported previously for a shorter time and very mild reaction condition, as well as for a ready for use reagent.
Rodríguez
J C
JC
Departamento de Síntesis Química, Centro de Química Farmacéutica, Ciudad de La Habana, Cuba.
Hernández
R
R
González
M
M
López
M A
MA
Fini
A
A
D002439:Cefotaxime / Q000138:chemical synthesis* / Q000737:chemistry; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy
D002511:Cephalosporins; D002439:Cefotaxime