Increased homocyst(e)ine associated with smoking, chronic inflammation, and aging may reflect acute-phase induction of pyridoxal phosphatase activity.
Smokers, patients with chronic inflammatory disorders, and the elderly, are characterized by increased production of IL-6 as well as increased plasma levels of homocyst(e)ine. Analysis of cirrhotic livers suggests that IL-6 may stimulate the activity of pyridoxal phosphatase in hepatocytes, thereby diminishing pyridoxal phosphate levels, compromising cystathionine beta-synthase activity, and raising plasma homocyst(e)ine. Adequate supplemental intakes of pyridoxine may be corrective in this regard.
McCarty
M F
MF
Pantox Laboratories, San Diego, CA 92109, USA.
D000210:Acute-Phase Reaction / Q000503:physiopathology*; D000368:Aged; D000375:Aging / Q000097:blood / Q000276:immunology / Q000378:metabolism; D002908:Chronic Disease; D003069:Coffee / Q000009:adverse effects; D004790:Enzyme Induction; D006710:Homocysteine / Q000097:blood*; D006711:Homocystine / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D010744:Phosphoric Monoester Hydrolases / Q000096:biosynthesis*; D011736:Pyridoxine / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects / Q000097:blood / Q000276:immunology
D003069:Coffee; D015850:Interleukin-6; D006710:Homocysteine; D006711:Homocystine; C027138:pyridoxine phosphate phosphatase; D010744:Phosphoric Monoester Hydrolases; D011736:Pyridoxine