Genetic control of cell size.
Over the past 25 years, the genetic control of cell size has mainly been addressed in yeast, a single-celled organism. Recent insights from Drosophila have shed light on the signalling pathways responsible for adjusting and maintaining cell size in metazoans. Evidence is emerging for a signalling cascade conserved in evolution that links external nutrient sources to cell size.
Stocker
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Zoologisches Institut, Universität Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
Hafen
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D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D048429:Cell Size / Q000235:genetics*; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics / Q000254:growth & development*; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000502:physiology; D011972:Receptor, Insulin / Q000502:physiology; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins
D016271:Proto-Oncogene Proteins c-myc; D025521:Tumor Suppressor Proteins; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase