title: [Interest in variations in soluble ICAM-1 plasma levels. From physiology to clinical applications].
abstract: Intracellular adhesion molecule 1 (ICAM-1) is an adhesion-related molecule belonging to the immunoglobulin superfamily. This molecule is found on the cell membrane of endothelial cells. When activated ICAM-1 allows stable leukocyte adhesion to the endothelial surface. ICAM-1 is found not only in the membrane form but also circulating in serum. ICAM-1 (extracellular part of ICAM-1). This enables ICAM-1s to bind leukocyte integrin receptors such as LFA-1 (CDI1a/CD18) and Mac-1 (CDI1b/CD18) and therefore provide adaptive changes in the adhesion process between circulating cells and the endothelium.
authors.affiliation: Laboratoire Universitaire d'Hématologie, Université Victor Ségalen, Bordeaux, France.
authors.forename: E
authors.initials: E
authors.lastname: Gomez-Scotto
authors.forename: M
authors.initials: M
authors.lastname: Seigneur
authors.forename: M
authors.initials: M
authors.lastname: Renard
authors.forename: L L
authors.initials: LL
authors.lastname: Houbouyan-Reveillard
authors.forename: M R
authors.initials: MR
authors.lastname: Boisseau
mesh_terms: D002448:Cell Adhesion; D004194:Disease; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007962:Leukocytes / Q000502:physiology; D012016:Reference Values
chemical_list: D018799:Intercellular Adhesion Molecule-1