title: Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma.
abstract: Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged animal lifespan by 40-60% in comparison with the control. The correlation coefficient between the tumor size and antibody titer after injection of mucin was -0.4 for IgM and -0.6 for IgG. Titration of IgG may be used for monitoring of the efficiency of specific immunotherapy.
authors.affiliation: N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences.
authors.forename: B S
authors.initials: BS
authors.lastname: Amandzholov
authors.forename: S M
authors.initials: SM
authors.lastname: Sitdikova
authors.forename: Y S
authors.initials: YS
authors.lastname: Lebedin
authors.forename: S V
authors.initials: SV
authors.lastname: Chukanov
authors.forename: A Y
authors.initials: AY
authors.lastname: Toptygin
authors.forename: L V
authors.initials: LV
authors.lastname: Manzyuk
authors.forename: F V
authors.initials: FV
authors.lastname: Donenko
mesh_terms: D000818:Animals; D018394:CA-125 Antigen / Q000276:immunology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D008808:Mice, Inbred CBA; D009077:Mucins / Q000276:immunology* / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000628:therapy*
chemical_list: D018394:CA-125 Antigen; D009077:Mucins