[The role of D1-dependent dopaminergic mechanisms in the frontal cortex in the rat latent response].
The effects of microinjections of D1 selective dopaminergic substances into the medial frontal cortex (MFC) on information storage and proactive interference during delayed (the delay in 3 s) and non-delayed choice in Y-maze were studied. Bilateral microinjection of D1 receptor antagonist SCH 23390 (1 nM, 1 microliter) impaired both delayed and non-delayed choice. In contrast, microinjections of D1 receptor agonist SKF 38393 (1 nM) into the MFC significantly improved the delayed performance and did not influence the non-delayed choice. The effects of proactive interference caused by SCH 23390 and SKF 38393 injections were more pronounced in delayed choice condition than in the non-delayed task. Spatial bias in animal behavior was revealed after the SCH 23390 injections: during erroneous choices rats more frequently turned in the same direction as preferred in a rotation test. The results suggest that impairment of delayed performance in Y-maze observed under the blockade of D1-mediated neurotransmission in the MFC occurs due to enhancement of the processes of proactive interference and disinhibition of the spatial set.
Kozlov
A P
AP
Research Institute for Experimental Medicine, St.-Petersburg.
Druzin
M Ia
MIa
Kurzina
N P
NP
Malinina
E P
EP
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008570:Memory, Short-Term / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000502:physiology*
D001552:Benzazepines; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine