[Induction chemotherapy and radiotherapy in locally advanced head and neck carcinoma].
The value of inductive chemotherapy preceding the radical irradiation of locally advanced neoplasms of head and neck has been estimated. The following have been applied: cisplatin, adriamycin, bleomycin, or cyclophosphamide, adriamycin, 5-fluorouracil, or cisplatin 5-fluorouracil. A reaction to treatment in the form of CR and PR has been achieved in 71.5% of the treated patients. Irradiation was started in two to four weeks after chemotherapy had been stopped. After combined treatment the proportion of 69.5% CR and PR was achieved. The average length of time of CR and PR was 8.7 months. Treatment was well tolerated.
Boguszewska
D
D
Katedra i Zakład Onkologii AM w Lublinie.
Mazurkiewicz
M
M
Grzybowska-Szatkowska
L
L
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging