Intestinal absorption of acidic beta-lactam antibiotics: contribution of ionized and un-ionized forms.
The effect of the pH of dissolutions of weakly acidic beta-lactam antibiotics on their intestinal absorption has been studied by quantification of the contribution of the ionized and un-ionized antibiotic forms to the whole absorptive process. In vivo recirculation in both sexes of adult Wistar rats was performed with buffer solutions at different pH values and samples were analyzed by high-performance liquid chromatography (HPLC).
Prieto
J G
JG
Laboratory of Animal Physiology, Faculty of Biology, León University, Spain.
Santos
L
L
Barrio
J P
JP
Alonso
M L
ML
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams