title: Detection of herpes simplex virus type 1 in human vestibular nuclei.
abstract: The distribution of herpes simplex virus type 1 (HSV-1) in human geniculate, vestibular ganglia, and vestibular nuclei was determined in 10 human temporal bones and brainstems of five individuals by PCR. HSV-1 was found in 3 of 10 of each ganglia and vestibular nuclei. The various patterns of HSV-1 infection of vestibular structures are compatible with virus migration from the vestibular ganglia to the vestibular nuclei and from the ipsilateral to the contralateral vestibular nucleus via commissural fibers.
authors.affiliation: Department of Neurology, Klinikum Grobetahadern, University of Munich, Munich, Germany. varbusow@nro.med.uni-muenchen.de
authors.forename: V
authors.initials: V
authors.lastname: Arbusow
authors.forename: M
authors.initials: M
authors.lastname: Strupp
authors.forename: R
authors.initials: R
authors.lastname: Wasicky
authors.forename: A K
authors.initials: AK
authors.lastname: Horn
authors.forename: P
authors.initials: P
authors.lastname: Schulz
authors.forename: T
authors.initials: T
authors.lastname: Brandt
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006561:Herpes Simplex / Q000473:pathology* / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014726:Vestibular Nuclei / Q000821:virology*