The role of T cells in autoimmune uveitis.
Autoimmune diseases result from the activation of self-reactive T cells recognizing autoantigens or foreign antigens cross-reactive with an autoantigen. T cells are thought to play a major role in autoimmune diseases in different organs, including the eye. This review focuses on the role of T cells in autoimmune uveitis in humans and in animal models of experimental autoimmune uveitis. Since rheumatoid arthritis is an autoimmune disease that has been studied far more extensively than uveitis, we have also included a review of clinical and experimental observations relevant to that disease.
Becker
M D
MD
Casey Eye Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA. beckemat@ohsu.edu
Adamus
G
G
Davey
M P
MP
Rosenbaum
J T
JT
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D012720:Severity of Illness Index; D013601:T-Lymphocytes / Q000502:physiology*; D014605:Uveitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
D015703:Antigens, CD; D016207:Cytokines; D006680:HLA Antigens