title: Association of PEEP with two different inflation volumes in ARDS patients: effects on passive lung deflation and alveolar recruitment.
abstract: OBJECTIVE
  To assess the effects of the association of positive end-expiratory pressure (PEEP) with different inflation volumes (V(T)'s) on passive lung deflation and alveolar recruitment in ARDS patients.
  
  
  METHODS
  Clinical study using PEEP with two different V(T)'s and analyzing whether passive lung deflation and alveolar recruitment (Vrec) depend on end-inspired (EILV) or end-expired (EELV) lung volume in mechanically ventilated ARDS patients.
  
  
  METHODS
  Medical intensive care unit in a university hospital.
  
  
  METHODS
  Six mechanically ventilated consecutive supine patients with ARDS.
  
  
  METHODS
  Time-course of thoracic volume decay during passive expiration and Vrec were investigated in six ARDS patients ventilated on PEEP with baseline V(T) (V(T),b) and 0.5V(T) (0.5V(T),b), and on zero PEEP (ZEEP) with V(T),b. Time constants of the fast (tau1) and slow (tau2) emptying compartments, as well as resistances and elastances were also determined.
  
  
  RESULTS
  (a) the biexponential model best fitted the volume decay in all instances. The fast compartment was responsible for 84+/-7 (0.5V(T),b) and 86+/-5% (V(T),b) on PEEP vs 81+/-6% (V(T),b) on ZEEP (P:ns) of the exhaled V(T), with tau1 of 0.50+/-0.13 and 0.58+/-0.17 s vs 0.35+/-0.11 s, respectively; (b) only tau1 for V(T),b on PEEP differed significantly (P < 0.02) from the one on ZEEP, suggesting a slower initial emptying; (c) for the same PEEP, Vrec was higher with a higher volume (V(T)b) than at a lesser one (0.5V(T),b), reflecting the higher V(T).
  
  
  CONCLUSIONS
  In mechanically ventilated ARDS patients: (a) the behavior of airway resistance seems to depend on the degree of the prevailing lung distension; (b) alveolar recruitment appears to be more important when higher tidal volumes are used during mechanical ventilation on PEEP; (c) PEEP changes the mechanical properties of the respiratory system fast-emptying compartment.
authors.affiliation: Department of Critical Care Medicine, University of Florence, Italy. g.chelucci@dfc.unifi.it
authors.forename: G L
authors.initials: GL
authors.lastname: Chelucci
authors.forename: J
authors.initials: J
authors.lastname: Dall'Ava-Santucci
authors.forename: J F
authors.initials: JF
authors.lastname: Dhainaut
authors.forename: A
authors.initials: A
authors.lastname: Chelucci
authors.forename: A
authors.initials: A
authors.lastname: Allegra
authors.forename: A
authors.initials: A
authors.lastname: Lockhart
authors.forename: W A
authors.initials: WA
authors.lastname: Zin
authors.forename: J
authors.initials: J
authors.lastname: Milic-Emili
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D005260:Female; D006801:Humans; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000379:methods*; D011650:Pulmonary Alveoli / Q000502:physiology*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology*; D015656:Respiratory Mechanics; D013990:Tidal Volume