Interaction of syntaxins with epithelial ion channels.
Recent evidence suggests that some of the syntaxin isoforms may physically interact with and regulate the transport activity of a defined set of membrane transport proteins. This review examines recent studies of the cystic fibrosis transmembrane conductance regulator and the epithelial sodium channel which define distinct roles of syntaxin 1A and syntaxin 3 in the regulation of surface expression as well as intrinsic properties of these epithelial ion transporters.
Saxena
S
S
Nephrology Research and Training Center, Department of Medicine, University of Alabama at Birmingham, USA.
Quick
M W
MW
Warnock
D G
DG
D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism; D053503:Epithelial Sodium Channels; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D050765:Qa-SNARE Proteins; D050600:SNARE Proteins; D015222:Sodium Channels / Q000378:metabolism*; D050827:Syntaxin 1; D033921:Vesicular Transport Proteins
C505032:CFTR protein, human; D053503:Epithelial Sodium Channels; D008565:Membrane Proteins; D050765:Qa-SNARE Proteins; D050600:SNARE Proteins; C494212:STX1A protein, human; D015222:Sodium Channels; D050827:Syntaxin 1; D033921:Vesicular Transport Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator