title: Comparative genomics and understanding of microbial biology.
abstract: The sequences of close to 30 microbial genomes have been completed during the past 5 years, and the sequences of more than 100 genomes should be completed in the next 2 to 4 years. Soon, completed microbial genome sequences will represent a collection of >200,000 predicted coding sequences. While analysis of a single genome provides tremendous biological insights on any given organism, comparative analysis of multiple genomes provides substantially more information on the physiology and evolution of microbial species and expands our ability to better assign putative function to predicted coding sequences.
authors.affiliation: The Institute for Genomic Research, Rockville, Maryland 20850, USA. cmfraser@tigr.org
authors.forename: C M
authors.initials: CM
authors.lastname: Fraser
authors.forename: J
authors.initials: J
authors.lastname: Eisen
authors.forename: R D
authors.initials: RD
authors.lastname: Fleischmann
authors.forename: K A
authors.initials: KA
authors.lastname: Ketchum
authors.forename: S
authors.initials: S
authors.lastname: Peterson
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity; D002352:Carrier Proteins / Q000235:genetics; D019143:Evolution, Molecular; D020745:Genome, Archaeal; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods*; D006801:Humans; D017421:Sequence Analysis
chemical_list: D002352:Carrier Proteins