title: The effects of ductal obstruction on the acinar cells of the parotid of cat.
abstract: Twenty-nine parotids ligated for between 1 and 365 days were examined by light and electron microscopy. Major changes in the acini were seen at 4 days and included vacuolation, disintegration, extravasation, apoptosis, phagy and a reduction in number and size of secretory granules. There was a further reduction in secretory granules from 7 to 12 days, but acinar cells persisted even up to 365 days, some contained a luminal concentration of small secretory granules and occasionally acinar cells of a similar appearance to normal were found. These findings contrast with a reported absence of acinar cells from the obstructed parotid of rat and show that parotid acinar cells are able to persist and retain an appearance indicative of secretory activity.
authors.affiliation: Department of Oral Pathology, The Rayne Institute, Guy's, King's and St Thomas's Dental Institute, 123 Coldharbour Lane, SE5 9NU, London, UK.
authors.forename: J D
authors.initials: JD
authors.lastname: Harrison
authors.forename: H M
authors.initials: HM
authors.lastname: Fouad
authors.forename: J R
authors.initials: JR
authors.lastname: Garrett
mesh_terms: D000818:Animals; D017209:Apoptosis; D002415:Cats; D048429:Cell Size; D018870:Endoplasmic Reticulum, Rough / Q000648:ultrastructure; D008026:Ligation; D008264:Macrophages / Q000473:pathology; D008854:Microscopy, Electron; D009504:Neutrophils / Q000473:pathology; D010305:Parotid Diseases / Q000473:pathology*; D018987:Salivary Ducts / Q000473:pathology* / Q000648:ultrastructure; D012466:Salivary Gland Diseases / Q000473:pathology*; D022142:Secretory Vesicles / Q000648:ultrastructure; D013997:Time Factors; D014617:Vacuoles / Q000648:ultrastructure