New pyrazolo[3,4-b]pyrazines: synthesis and biological activity.
Some new pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized and evaluated for their antifungal and antiparasitic activities. The key intermediate, 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile (3) was obtained in a one-pot synthesis via the reaction of 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 2 with malononitrile.
el-Kashef
H S
HS
Chemistry Department, Faculty of Science, Assiut University, Egypt. elkashef@aun.eun.eg
el-Emary
T I
TI
Gasquet
M
M
Timon-David
P
P
Maldonado
J
J
Vanelle
P
P
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007891:Leishmania / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010271:Parasites / Q000187:drug effects*; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014246:Trichomonas vaginalis / Q000187:drug effects
D000935:Antifungal Agents; D011719:Pyrazines; D011720:Pyrazoles