[Transdermal administration of drugs by electroporation].
Short high-voltage pulses have been shown to increase, accelerate and broaden transdermal drug delivery to molecules of variable physicochemical properties, i.e., from 18 to 38,000 Da, hydro- and lipophilic, neutral and charged molecules, via a mechanism hypothesized to involve electroporation of the stratum corneum lipid bilayers. Transport is increased by up to 4 orders of magnitude, and onset times for significant transport reduce from hours by passive diffusion to a few minutes.
Vanbever
R
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Unité de Pharmacie galénique, industrielle et officinale, Ecole de Pharmacie, Faculté de Médecine, U.C.L., Bruxelles.
D000279:Administration, Cutaneous; D004058:Diffusion; D018274:Electroporation / Q000379:methods*; D006801:Humans; D010539:Permeability; D012869:Skin Absorption; D013997:Time Factors