title: Multifocal electroretinogram abnormalities persist following resolution of central serous chorioretinopathy.
abstract: OBJECTIVE
  To examine results of the multifocal electroretinogram (MERG) after spontaneous resolution of central serous chorioretinopathy (CSC) detachments.
  
  
  METHODS
  Multifocal electroretinograms were recorded from both eyes of 5 recovered patients with CSC and 10 age-matched healthy subjects. All patients with CSC had bilaterally subnormal MERG amplitudes during a first attack of CSC occuring 7 to 23 months earlier.
  
  
  RESULTS
  After recovery from CSC, MERG A-wave and B-wave amplitudes increased markedly where the detachment resolved, and moderately elsewhere in the posterior pole of both eyes. However, the signals from both eyes remained either subnormal or low-normal relative to controls. Multifocal electroretinogram B-wave latencies improved from prolonged to mid-normal values in both eyes.
  
  
  CONCLUSIONS
  Both eyes of patients with active unilateral CSC exhibit diminished MERG amplitudes. Although MERG response amplitudes increased modestly after recovery from CSC, they remained statistically subnormal throughout the posterior pole of both eyes. These findings support the theory that subretinal fluid retention in CSC is secondary to diffuse pathologic changes in the choroid and/or retinal pigment epithelium. They also suggest that the underlying or predisposing abnormalities of CSC resolved only partially in our patients. Components of the MERG may have value as a prognostic tool for judging the risk of developing symptomatic CSC. Arch Ophthalmol. 2000;118:1211-1215
authors.affiliation: Department of Ophthalmology, Stanford University, Stanford, CA 94305-5308, USA.
authors.forename: A V
authors.initials: AV
authors.lastname: Chappelow
authors.forename: M F
authors.initials: MF
authors.lastname: Marmor
mesh_terms: D000328:Adult; D015862:Choroid Diseases / Q000175:diagnosis / Q000503:physiopathology*; D004596:Electroretinography / Q000379:methods*; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous; D012160:Retina / Q000503:physiopathology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000503:physiopathology*; D014792:Visual Acuity