Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis.
Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toxoid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.
Hume
E B
EB
Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Dajcs
J J
JJ
Moreau
J M
JM
O'Callaghan
R J
RJ
D000818:Animals; D003315:Cornea / Q000382:microbiology / Q000473:pathology*; D015818:Eye Infections, Bacterial / Q000276:immunology / Q000473:pathology; D007114:Immunization; D007634:Keratitis / Q000382:microbiology / Q000473:pathology*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000276:immunology* / Q000378:metabolism; D014121:Toxoids / Q000276:immunology*; D010738:Type C Phospholipases / Q000008:administration & dosage / Q000276:immunology*
D014121:Toxoids; D010738:Type C Phospholipases