title: A comparison of anaesthetic tensions in arterial blood and oxygenator exhaust gas during cardiopulmonary bypass.
abstract: This study evaluates the usefulness of the analysis of gas sampled from the exhaust port of a membrane oxygenator in the estimation of anaesthetic tension in arterial blood. Sixty-seven arterial blood samples were drawn from patients undergoing hypothermic cardiopulmonary bypass with anaesthesia maintained by either isoflurane or desflurane. Anaesthetic tensions in the oxygenator exhaust gas were measured using an infrared analyser and in arterial blood using a two-stage headspace technique with a gas chromatograph. Both measurement systems were calibrated with the same standard gas mixtures. There was no difference in anaesthetic tension measured in arterial blood and gas leaving the oxygenator exhaust (isoflurane: n = 29, range: 0.3-0.8%, 95% limits of agreement: -0.08% to 0.09%; desflurane: n = 38, range: 1.5-5.4%; 95% limits of agreement -0.65% to 0.58%). We conclude that anaesthetic tensions in arterial blood can be accurately monitored by analysis of the gas emerging from the exhaust port of a membrane oxygenator.
authors.affiliation: Division of Surgery, Anaesthesia and Intensive Care, Hammersmith Hospital, London, UK.
authors.forename: G G
authors.initials: GG
authors.lastname: Lockwood
authors.forename: S M
authors.initials: SM
authors.lastname: Sapsed-Byrne
authors.forename: S
authors.initials: S
authors.lastname: Adams
mesh_terms: D018685:Anesthetics, Inhalation / Q000097:blood / Q000493:pharmacokinetics*; D002245:Carbon Dioxide / Q000097:blood; D002315:Cardiopulmonary Bypass; D000077335:Desflurane; D005069:Evaluation Studies as Topic; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics; D016343:Monitoring, Intraoperative / Q000379:methods*; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D010313:Partial Pressure
chemical_list: D018685:Anesthetics, Inhalation; D002245:Carbon Dioxide; D000077335:Desflurane; D007530:Isoflurane; D010100:Oxygen