Proton transfer: it's a stringent process.
Proton transfer into and out of proteins is important, both for many enzyme reaction mechanisms and proton pumping across membranes. Recent work on several proteins has revealed stringent requirements for amino-acid side chains and subtle reorganisation of hydrogen-bond networks involving bound water molecules.
Ferguson
S J
SJ
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. ferguson@bioch.ox.ac.uk
D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011506:Proteins / Q000737:chemistry*; D011522:Protons
D011506:Proteins; D011522:Protons