title: Randomized study of intravenous fluid preload before epidural analgesia during labour.
abstract: We performed a randomized controlled trial of the effect of intravenous fluid preload on maternal hypotension and fetal heart rate (FHR) changes in labour after the first epidural injection. Group 1 (49 women) received 1 litre of crystalloid preload. Group 2 (46 women) received no preload. No statistically significant difference was shown between the two groups for either of the outcomes. Hypotension was found in three women in group 1 and five in group 2 (P = 0.4). Deterioration in FHR pattern was found in four women in group 1 and 11 in group 2 (P = 0.08). This study has not shown a significant increase in the incidence of hypotension when intravenous preload is omitted before epidural analgesia using a low concentration of bupivacaine during labour. Because of the clinical importance of the difference in the rate of FHR deterioration between the two groups, we continue to administer preload for high-risk cases.
authors.affiliation: Sir Humphry Davy Department of Anaesthesia, St Michael's Hospital, Bristol, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: Kinsella
authors.forename: M
authors.initials: M
authors.lastname: Pirlet
authors.forename: M S
authors.initials: MS
authors.lastname: Mills
authors.forename: J P
authors.initials: JP
authors.lastname: Tuckey
authors.forename: T A
authors.initials: TA
authors.lastname: Thomas
mesh_terms: D015360:Analgesia, Epidural / Q000379:methods*; D016362:Analgesia, Obstetrical / Q000379:methods*; D005260:Female; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000517:prevention & control*; D007262:Infusions, Intravenous; D007744:Obstetric Labor Complications / Q000517:prevention & control*; D011247:Pregnancy