title: Synthesis of (-)-neplanocin A analogues as potential antiviral agents.
abstract: Based on (-)-neplanocin A with the 5'-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo- and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.
authors.affiliation: College of Pharmacy, Seoul National University, Korea.
authors.forename: D H
authors.initials: DH
authors.lastname: Shin
authors.forename: H W
authors.initials: HW
authors.lastname: Lee
authors.forename: S S
authors.initials: SS
authors.lastname: Park
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: L S
authors.initials: LS
authors.lastname: Jeong
authors.forename: M W
authors.initials: MW
authors.lastname: Chun
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; C031096:neplanocin A; D000241:Adenosine