title: EPIFIL: the development of an age-structured model for describing the transmission dynamics and control of lymphatic filariasis.
abstract: Mathematical models of transmission dynamics of infectious diseases provide a useful tool for investigating the impact of community based control measures. Previously, we used a dynamic (constant force-of-infection) model for lymphatic filariasis to describe observed patterns of infection and disease in endemic communities. In this paper, we expand the model to examine the effects of control options against filariasis by incorporating the impact of age structure of the human community and by addressing explicitly the dynamics of parasite transmission from and to the vector population. This model is tested using data for Wuchereria bancrofti transmitted by Culex quinquefasciatus in Pondicherry, South India. The results show that chemotherapy has a larger short-term impact than vector control but that the effects of vector control can last beyond the treatment period. In addition we compare rates of recrudescence for drugs with different macrofilaricidal effects.
authors.affiliation: Department of Computing Science and Mathematics, University of Stirling, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Norman
authors.forename: M S
authors.initials: MS
authors.lastname: Chan
authors.forename: A
authors.initials: A
authors.lastname: Srividya
authors.forename: S P
authors.initials: SP
authors.lastname: Pani
authors.forename: K D
authors.initials: KD
authors.lastname: Ramaiah
authors.forename: P
authors.initials: P
authors.lastname: Vanamail
authors.forename: E
authors.initials: E
authors.lastname: Michael
authors.forename: P K
authors.initials: PK
authors.lastname: Das
authors.forename: D A
authors.initials: DA
authors.lastname: Bundy
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003465:Culex; D004605:Elephantiasis, Filarial / Q000188:drug therapy / Q000635:transmission*; D005260:Female; D005369:Filaricides / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007300:Insect Control; D007303:Insect Vectors; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical
chemical_list: D005369:Filaricides