Variation of the antimicrobial activity of Pseudognaphalium vira vira (Asteraceae): isolation and X-ray structure of ent-3beta-hydroxy-16-kauren-19-oic acid.
The antimicrobial properties of the resinous exudate from twigs and leaves of a population of Pseudognaphalium vira vira were re-examined against five Gram positive bacteria. The observed decrease in the antimicrobial activity might reflect a change in the diterpenoid composition of the exudate. The title compound 2 was isolated in substantial amount, together with ent-16-kauren-19-oic acid (1), and its structure determined by X-ray diffraction analysis.
Rezende
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MC
Facultad de Química y Biología, Universidad de Santiago de Chile, Casilla 40, Correo 33, Santiago, Chile. mcaroli@lauca.usach.cl
Urzua
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Bortoluzzi
A J
AJ
Vásquez
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D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D014961:X-Ray Diffraction
C419505:3-hydroxy-16-kauren-19-oic acid; D000900:Anti-Bacterial Agents; D004224:Diterpenes