Development of antirotavirus agents in Asia.
Human rotaviruses are the major etiologic agents of diarrhea in infants and young children under 2 years of age worldwide. Rotavirus diarrhea is a life-threatening disease for children; many efforts are made to reduce the morbidity and mortality in Asia. To date many natural compounds and some Western medicines have exhibited their antirotavirus effects in clinical studies, in animal experiments and in vitro. Compared with antirotavirus agents in the USA and Europe, natural compounds have been identified as ideal candidates for antirotaviral drugs in Asia because they are cheaper and effective, have no side-effect and no toxicity. We have attempted to reveal the antirotavirus mechanism of some natural compounds. We found that cacao pigment, tea extract and pine seed shell extract inhibit rotavirus adsorption to cells while cacao pigment may also inhibit rotavirus reproduction in vitro. The usage of antirotavirus agents in Asia demonstrated that additional effective approaches to control rotavirus infection, such as antirotavirus agents, are necessary, in particular for the children with rotavirus diarrhea who have severe complications.
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Department of Developmental Medical Sciences, School of International, Health, Graduate School of Medicine, University of Tokyo, Japan.
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Kodama
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Mueller
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Ushijima
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D000998:Antiviral Agents / Q000627:therapeutic use*; D001208:Asia; D002675:Child, Preschool; D015195:Drug Design; D006801:Humans; D007223:Infant; D007229:Infant Welfare; D007231:Infant, Newborn; D008518:Medicine, East Asian Traditional; D012400:Rotavirus Infections / Q000150:complications / Q000188:drug therapy*
D000998:Antiviral Agents