title: Relationship between MRI findings and prognosis for patients with general paresis.
abstract: MRI was performed in 7 patients with general paresis before or at a very early stage of treatment. A large dose of antibiotics, mainly penicillin, was given to all patients, and the effects of treatment, the patients' outcome, and MRI findings were investigated. Three of the 7 patients had MRI findings of atrophy of the medial temporal lobe including the hippocampus. In the medial temporal lobe atrophy group, a personality change or general dementia remained even after the treatment was completed, and outcome in social functioning was poor. Medial temporal lobe atrophy may be a poor prognostic sign in general paresis.
authors.affiliation: Department of Neuropsychiatry, Chiba University School of Medicine, Japan. kodama@med.m.chiba-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
authors.forename: N
authors.initials: N
authors.lastname: Yamanouchi
authors.forename: S
authors.initials: S
authors.lastname: Noda
authors.forename: C
authors.initials: C
authors.lastname: Kumakiri
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D000328:Adult; D001284:Atrophy; D002552:Cerebral Ventricles / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000473:pathology*; D011379:Prognosis; D013702:Temporal Lobe / Q000473:pathology; D016896:Treatment Outcome