Early age of disease onset in African American type 1 diabetes patients is associated with DQB1*0201 allele.
The goal of this study is to assess the association of HLA-DQ alleles with the age of onset of type 1 diabetes in African American patients. Using PCR oligonucleotide typing, HLA-DQA1 and DQB1 alleles were determined. DQA1*0301, DQB1*0201, and DQB1*0302 were significantly increased in African American patients. However, the DQB1*0602 allele was decreased in these patients. In addition, DQA1*0401 and DQB1*0402, were associated with protection in African Americans. When stratified by age of onset, prepubertal patients showed an absence of the protective allele DQB1*0602 and a significant increase in DQB1*0201 compared to postpubertal patients. The high frequency of the HLA-DQ susceptibility allele in pre-pubertal patients suggest that the biology of disease in this group may differ from type 1 diabetes with a later age of onset.
Berka
N
N
Immunogenetics Laboratory, Howard University College of Medicine, Washington, DC, USA. nberk001@umaryland.edu
Bland
G N
GN
Gause
D P
DP
Harris
P F
PF
Erabhaoui
E H
EH
Bonar
A S
AS
Dunston
G M
GM
D001741:Black or African American; D017668:Age of Onset; D000483:Alleles; D044383:Black People / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology; D005838:Genotype; D006683:HLA-DQ Antigens / Q000145:classification / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006239:Haplotypes; D006801:Humans
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen