title: Refined localization and two additional linked families for the DFNA10 locus for nonsyndromic hearing impairment.
abstract: DFNA10 originally was mapped to the long arm of chromosome 6 in a large American family segregating for autosomal dominant progressive nonsyndromic hearing impairment. By extending this American family, we have reduced the original DFNA10 candidate region from 13 cM to 3.7 cM. We also report a Belgian family with autosomal dominant nonsyndromic hearing impairment linked to DFNA10 and a Norwegian family with the same condition in which linkage is suggestive, although maximum lod scores are only 2.5. The hearing phenotype in all three DFNA10 families is similar, with losses beginning in the middle frequencies and involving the low and high frequencies later in life.
authors.affiliation: Department of Medical Genetics, University of Antwerp, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Verhoeven
authors.forename: T
authors.initials: T
authors.lastname: Fagerheim
authors.forename: S
authors.initials: S
authors.lastname: Prasad
authors.forename: S
authors.initials: S
authors.lastname: Wayne
authors.forename: F
authors.initials: F
authors.lastname: De Clau
authors.forename: W
authors.initials: W
authors.lastname: Balemans
authors.forename: M
authors.initials: M
authors.lastname: Verstreken
authors.forename: I
authors.initials: I
authors.lastname: Schatteman
authors.forename: B
authors.initials: B
authors.lastname: Solem
authors.forename: P
authors.initials: P
authors.lastname: Van de Heyning
authors.forename: L
authors.initials: L
authors.lastname: Tranebjärg
authors.forename: R J
authors.initials: RJ
authors.lastname: Smith
authors.forename: G
authors.initials: G
authors.lastname: Van Camp
mesh_terms: D001299:Audiometry; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D003638:Deafness / Q000235:genetics*; D020224:Expressed Sequence Tags; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D010641:Phenotype
chemical_list: D005819:Genetic Markers