[Endothelial factors in the regulation of Na+, K(+)-ATPase].
Endothelial vasoactive agents such as endothelin, angiotensin, nitric oxide and others are essential in regulation of the Na-pump functions in vascular and others tissues. In our review the intracellular mechanisms of activating and inhibition of the Na+,K(+)-ATPase by endothelial vasoactive agents are discussed. In the control of vascular tone and heart function as well as the regulation of the Na-pump endothelial vasoactive agents act individually or in close interaction with other physiologically active substances including the ouabain-like factor, endogenous inhibitor of the Na-pump. Some aspects ouabain-like factor physiological action are under the discussion. Recent advances in study and comprehension of intracellular mechanisms the mediating role of endothelial agents in Na-pump regulation are reviewed also.
Vavilova
H L
HL
A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Akopova
O V
OV
Sahach
V F
VF
D000818:Animals; D001685:Biological Factors / Q000502:physiology; D002298:Cardenolides; D004077:Digoxin; D015777:Eicosanoids / Q000502:physiology; D016232:Endothelins / Q000502:physiology*; D004730:Endothelium, Vascular / Q000201:enzymology / Q000502:physiology; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology; D017466:Receptors, Endothelin / Q000502:physiology; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000502:physiology*
D001685:Biological Factors; D002298:Cardenolides; D015777:Eicosanoids; D016232:Endothelins; D017466:Receptors, Endothelin; D012503:Saponins; C034504:digoxin-like factors; D009569:Nitric Oxide; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase