title: The relationship between survival and cell proliferation index in squamous cell carcinoma of larynx.
abstract: Cell proliferation index is one of the most important factors in assessment of growth and progression of tumours. At present, the most suitable method of determining cell proliferation is by means of immunohistochemical techniques which use the monoclonal anti-body MIB-1 which reacts against Ki-67, a protein released only in the proliferation phases of the cell cycle. In this study, 44 patients diagnosed with squamous cell carcinoma of the larynx were analysed retrospectively and different macroscopic and microscopic parameters were assessed, such as MIB-1 in relation to the current status of the patient. A statistically significant relationship was found between the cell proliferation index, the histological grade of differentiation and the clinical evolution of the illness.
authors.affiliation: University Complex of Santiago, Department of Otorhinolaryngology, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Pérez Carro Ríos
authors.forename: T
authors.initials: T
authors.lastname: García Caballero
authors.forename: A
authors.initials: A
authors.lastname: Lozano Ramírez
authors.forename: M D
authors.initials: MD
authors.lastname: Arias Santos
authors.forename: A
authors.initials: A
authors.lastname: Soto Varela
authors.forename: J
authors.initials: J
authors.lastname: Forteza Vila
authors.forename: T
authors.initials: T
authors.lastname: Labella Caballero
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000401:mortality* / Q000473:pathology*; D002455:Cell Division; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate