Synthesis and antimicrobial activity of squalamine analogue.
Synthesis and antimicrobial activity of squalamine analogue 2 are reported. The synthesis of 2 was accomplished from bisnoralcohol 3. The spermidine moiety was introduced via reductive amination of an appropriately functionalized 3beta-aminosterol with spermidinyl aldehyde 17 utilizing sodium triacetoxyborohydride as the reducing agent. Compound 2 shows weaker antimicrobial activity than squalamine.
Kim
H S
HS
Department of Industrial Chemistry, Kyungpook National University, Taegu, South Korea. kimhs@knu.ac.kr
Choi
B S
BS
Kwon
K C
KC
Lee
S O
SO
Kwak
H J
HJ
Lee
C H
CH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002777:Cholestanols / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013095:Spermidine / Q000737:chemistry
D000900:Anti-Bacterial Agents; D002777:Cholestanols; C079655:squalamine; D013095:Spermidine