title: Two novel cytotoxic benzofuran derivatives from Brazilian propolis.
abstract: Two novel benzofuran derivatives, propolis-benzofurans A (1) and B (2), were isolated from the MeOH extract of Brazilian propolis, together with two known isoprenylated compounds (E)-3-[2, 3-dihydro-2-(1-methylethenyl)-7-prenyl-5-benzofuranyl]-2-propen oic acid and (E)-3-¿4-hydroxy-3-[(E)-4-(2, 3-dihydrocinnamoyloxy)-3-methyl-2-butenyl]-5-prenylphenyl¿-2 -propenoi c acid. The structures of these compounds were elucidated on the basis of spectral analysis. Both the new compounds exhibited mild cytotoxicity toward highly liver-metastatic murine colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cells.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan.
authors.forename: A H
authors.initials: AH
authors.lastname: Banskota
authors.forename: Y
authors.initials: Y
authors.lastname: Tezuka
authors.forename: K
authors.initials: K
authors.lastname: Midorikawa
authors.forename: K
authors.initials: K
authors.lastname: Matsushige
authors.forename: S
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D011429:Propolis / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001572:Benzofurans; D011429:Propolis