Improvement in cardiac function and free fatty acid metabolism in a case of dilated cardiomyopathy with CD36 deficiency.
A 27-year-old man diagnosed as having dilated cardiomyopathy (DCM) without myocardial accumulation of 123I-beta-methyl-iodophenylpentadecanoic acid, and he was found to have type I CD36 deficiency. This abnormality of cardiac free fatty acid metabolism was also confirmed by other methods: 18F-fluoro-2-deoxyglucose positron emission tomography, measurements of myocardial respiratory quotient and cardiac fatty acid uptake. Although the type I CD36 deficiency was reconfirmed after 3 months, the abnormal free fatty acid metabolism improved after carvedilol therapy and was accompanied by improved cardiac function. Apart from a cause-and-effect relationship, carvedilol can improve cardiac function and increase free fatty acid metabolism in patients with both DCM and CD36 deficiency.
Hirooka
K
K
The Cardiology Division of Medicine, National Cardiovascular Center, Suita, Osaka, Japan. khirooka@hsp.ncvc.go.jp
Yasumura
Y
Y
Ishida
Y
Y
Komamura
K
K
Hanatani
A
A
Nakatani
S
S
Yamagishi
M
M
Miyatake
K
K
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D018955:CD36 Antigens / Q000378:metabolism*; D002227:Carbazoles / Q000008:administration & dosage; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology; D000077261:Carvedilol; D005227:Fatty Acids / Q000493:pharmacokinetics; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006334:Heart Function Tests / Q000379:methods*; D006801:Humans; D007462:Iodobenzenes / Q000493:pharmacokinetics; D008297:Male; D011412:Propanolamines / Q000008:administration & dosage; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics
D000319:Adrenergic beta-Antagonists; D018955:CD36 Antigens; D002227:Carbazoles; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007462:Iodobenzenes; D011412:Propanolamines; D019275:Radiopharmaceuticals; C049338:iodofiltic acid; D000077261:Carvedilol; D019788:Fluorodeoxyglucose F18