Hemolytic polar steroidal constituents of the starfish Aphelasterias japonica.
A reinvestigation of the polar steroid fraction from the starfish Aphelasterias japonica, collected near the Russian shore of the Sea of Japan, has afforded two new compounds, the disulfated quinovoside aphelasteroside C (1) and the monosulfated polyhydroxysteroid aphelaketotriol (2). Compounds 1 and 2 contain a unique 23-oxo-24-hydroxylated side chain that is unprecedented in marine steroids. The known compounds cheliferoside L1 (3), 3-O-sulfoasterone (4), forbeside E3 (5), and 3-O-sulfothornasterol A (6) were also isolated from this source. Compounds 1-3, 5, and 6 showed hemolytic activity to mouse erythrocytes.
Ivanchina
N V
NV
Pacific Institute of Bioorganic Chemistry of the Far East Branch of the Russian Academy of Science, Vladivostok-22, Russian Federation.
Kicha
A A
AA
Kalinovsky
A I
AI
Dmitrenok
P S
PS
Stonik
V A
VA
Riguera
R
R
Jiménez
C
C
D000818:Animals; D001681:Biological Assay; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D004912:Erythrocytes / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009904:Optical Rotation; D012426:Russia; D012964:Sodium / Q000032:analysis; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013054:Spectrophotometry, Atomic; D013055:Spectrophotometry, Infrared; D013215:Starfish / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D013256:Steroids; C414468:aphelaketotriol; C414467:aphelasteroside C; D012964:Sodium