[The pharmacokinetics of medamine and its solid polymeric form (medapek) in experimental larval alveolar echinococcosis in cotton rats].
Our study has shown that after single administration of its substance or its polymer formulation, medamine rapidly absorbs into blood, by penetrating into the host's viscera and tissues and parasitic larvocysts and excretes from the experimental animals' body at hour 24. Examining the distribution of medamine in the viscera and tissues has revealed that it penetrates into the rat viscera and tissue with blood and accumulated in the tissues. At the same time medamine given as a substance accumulates more in the excretory organs and medapec retains in the muscle tissue and brain longer. Medapec shows higher maximum concentrations at lower values of the pharmacokinetic curve area. Noticeable accumulation of medamine in the larvocysts of experimental animals confirms its chemotherapeutical activity.
Lopatina
N B
NB
Dzhabarova
V I
VI
Lebedeva
M N
MN
D000284:Administration, Oral; D000818:Animals; D000923:Anticestodal Agents / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D002219:Carbamates; D002851:Chromatography, High Pressure Liquid; D004353:Drug Evaluation, Preclinical; D004444:Echinococcosis, Hepatic / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D016205:Sigmodontinae; D013997:Time Factors; D014018:Tissue Distribution
D000923:Anticestodal Agents; D001562:Benzimidazoles; D002219:Carbamates; C006698:carbendazim