Effects of oral pinaverium bromide on colonic response to food in irritable bowel syndrome patients.
We have recently developed a simple method to investigate the colonic response to food (CRF). This study describes the modifications of CRF induced by treatment with oral pinaverium bromide in irritable bowel syndrome (IBS) patients. Thirty healthy subjects and 43 patients suffering from IBS were studied. Colonic transit time (CTT) was measured in fasting conditions and after eating a standard test meal. Colonic response to food was quantified by calculating the variation in number of markers in each zone of interest of the large bowel between the X-ray films of the abdomen taken before and after eating. CRF is characterized by caudal propulsion of colonic contents in the two groups. In controls, there is emptying of the caecum-ascending colon region and filling of the rectosigmoid. In IBS patients, only the left transverse colon and the splenic flexure empty. Pinaverium bromide exerts no effect in controls but reverses the CRF of the right colon in IBS patients by inhibiting right colon emptying. These results suggest that the inhibitory action of pinaverium bromide on CRF may support the clinical efficacy of this calcium channel blocker in the treatment of IBS.
Bouchoucha
M
M
Hôpital Laennec, Laboratoire de Physiologie digestive, Paris, France.
Faye
A
A
Devroede
G
G
Arsac
M
M
D000328:Adult; D003106:Colon / Q000503:physiopathology*; D003109:Colonic Diseases, Functional / Q000188:drug therapy* / Q000503:physiopathology*; D004435:Eating / Q000502:physiology; D005215:Fasting / Q000502:physiology; D005260:Female; D005502:Food / Q000009:adverse effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008297:Male; D009025:Morpholines / Q000627:therapeutic use*
D009025:Morpholines; C013199:pinaverium