Synthesis of (-)-neplanocin A analogues as potential antiviral agents.
Based on (-)-neplanocin A with the 5'-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo- and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.
Shin
D H
DH
College of Pharmacy, Seoul National University, Korea.
Lee
H W
HW
Park
S S
SS
Kim
J H
JH
Jeong
L S
LS
Chun
M W
MW
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; C031096:neplanocin A; D000241:Adenosine