Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
The adenylyl cyclase type VI gene expressed in human normal thyroid tissue was cloned and sequenced. The cDNA sequence (6463 nt) is susceptible to code for a 1168 aa protein. Northern blots using specific probes showed that the expression of adenylyl cyclase type VI gene was significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue, in one follicular cold adenoma or in one papillary carcinoma.
Wicker
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R
Institut de Recherches sur le Cancer CNRS IFR1221, Laboratoire d'Etude des Relations - Instabilité Génétique et Cancer UPR 2169, 7 rue Guy Môquet, B.P. no. 8, 94801 cedex, Villejuif, France.
Catalan
A G
AG
Cailleux
A
A
Starenki
D
D
Stengel
D
D
Sarasin
A
A
Suarez
H G
HG
D000236:Adenoma / Q000201:enzymology; D000262:Adenylyl Cyclases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry; D005091:Exons; D015870:Gene Expression; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D013961:Thyroid Gland / Q000201:enzymology*; D013964:Thyroid Neoplasms / Q000201:enzymology
D018076:DNA, Complementary; D000262:Adenylyl Cyclases; C121100:adenylyl cyclase 6