[Comparative effects of autologous blood transfusion and isovolemic colloids transfusion on hemorrhagic shock: measurement of NO production and tissue oxygen pressure].
Effects of autologous blood transfusion and isovolemic colloids transfusion on hemorrhagic shock model in rats were investigated. The hemorrhagic shock model in rats was prepared by rapid exsanguination and the blood pressure was kept at 40 mmHg for 30 min. As a marker of hemodynamic change, the blood gas analysis was performed, and the tissue oxygen pressure of the liver and the spleen was also measured. Furthermore, we analyzed the changes in NO production in the liver and the spleen of the hemorrhagic shock model. By hemorrhagic shock, Ht, HCO3-, base excess, and PaO2 levels decreased, and liver NO level, but not spleen NO, increased rapidly. However, the liver PtO2 did not show any changes during hemorrhagic shock, although the spleen PtO2 tended to decrease. These changes seen at the hemorrhagic shock were equally restored after the treatment with either autologous blood transfusion or isovolemic colloids transfusion. These results indicate that either autologous blood transfusion or isovolemic colloids transfusion can be useful for the therapy of severe hemorrhagic shock, and the NO production in the liver can participate in the maintenance of homeostasis under hemorrhagic shock.
Ishizaki
T
T
Department of Anesthesiology, Tokyo Medical University.
Isshiki
A
A
D000818:Animals; D001804:Blood Transfusion, Autologous; D004195:Disease Models, Animal; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D010101:Oxygen Consumption; D010313:Partial Pressure; D010952:Plasma Substitutes / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012771:Shock, Hemorrhagic / Q000378:metabolism / Q000628:therapy*
D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D009569:Nitric Oxide