title: Solid-phase synthesis of 4-substituted imidazoles using a scaffold approach.
abstract: Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles.
authors.affiliation: Leiden/Amsterdam Center for Drug Research (LACDR), Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Gelens
authors.forename: W J
authors.initials: WJ
authors.lastname: Koot
authors.forename: W M
authors.initials: WM
authors.lastname: Menge
authors.forename: H C
authors.initials: HC
authors.lastname: Ottenheijm
authors.forename: H
authors.initials: H
authors.lastname: Timmerman
mesh_terms: D007093:Imidazoles / Q000138:chemical synthesis*
chemical_list: D007093:Imidazoles