title: Post-exercise alcohol ingestion perturbs blood haemostasis during recovery.
abstract: It is known that exercise induces modification in blood haemostasis. It is, however, not known whether alcohol consumption post-exercise influences these modifications during recovery. Eleven moderately active young men were studied immediately after a standardised cycle ergometer test and during the 24-hour period of recovery. Alcohol (0. 7 g/kg body mass) was given 1 hour after exercise on one test occasion, while an equal volume of alcohol-free solution was administered on the other. Exercise induced a significant increase in factor VIII activity with a significant shortening of activated partial thromboplastin time. Parallel increases in tissue plasminogen activity and antigen with a concomitant decrease in tissue plasminogen activator inhibitor-1 activity were also observed after exercise. During recovery, while the increase in factor VIII activity post-exercise persisted in both trials, fibrinolytic activity demonstrated a sharp fall. The elevated factor VIII activity was significantly higher at 5 and 22 hours during the alcohol trial compared with the control. Although no demonstrable effect of alcohol on tissue plasminogen activator activity was present from 1 hour after ingestion onward, tissue plasminogen activator antigen and tissue plasminogen activator inhibitor-1 antigen increased significantly 22 hours following alcohol ingestion. Further comparison between trials revealed a higher plasminogen activator inhibitor-1 activity 5 hours after alcohol ingestion. In conclusion, exercise-induced changes to blood haemostasis are balanced during exercise but not during recovery. Alcohol consumption after physical exercise further perturbs blood haemostasis and could constitute a thrombotic risk.
authors.affiliation: Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, England, Liverpool, UK. m.s.elsayed@livjm.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: El-Sayed
authors.forename: A
authors.initials: A
authors.lastname: Omar
authors.forename: X
authors.initials: X
authors.lastname: Lin
mesh_terms: D000328:Adult; D000434:Alcoholic Beverages / Q000009:adverse effects; D000431:Ethanol / Q000494:pharmacology*; D015444:Exercise / Q000502:physiology*; D005169:Factor VIII / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D005343:Fibrinolytic Agents / Q000097:blood; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000187:drug effects
chemical_list: D005343:Fibrinolytic Agents; D017395:Plasminogen Activator Inhibitor 1; D000431:Ethanol; D005169:Factor VIII; D010959:Tissue Plasminogen Activator