Disorders of cortical development.
It is only a decade since the realization (facilitated by magnetic resonance imaging) in early 1990s that disorders of cortical development occupy an important place in the aetiologic categorization of epilepsy. Since then research has demonstrated the intrinsic epileptogenicity of disorders of cortical development, their genetic bases and their functional properties. Some of the key points of this most exciting medical and scientific enterprise are reviewed here, with an emphasis in the advances seen within the past 2 years.
Palmini
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Porto Alegre Epilepsy Surgery Program, Hospital São Lucas da Pontificia Universidade Católica do Rio Grande do Sul, Brazil.
D000818:Animals; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000601:surgery; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D004195:Disease Models, Animal; D004594:Electrophysiology / Q000379:methods; D004827:Epilepsy / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D013577:Syndrome