Association of DNase I phenotype 2 with colorectal carcinoma risk in Japanese populations.
We have already demonstrated a significant association of deoxyribonuclease I (DNase I; EC3.1.21.1) polymorphism with liver disease and gastric carcinoma. The aim of this study was to determine whether DNase I polymorphism is closely related to the incident of colorectal carcinoma. We have found a close statistical association between colorectal carcinoma and a high frequency of DNase I phenotype 2 in Japanese populations. However, there was no significant difference in the phenotype distribution between a group of patients with benign diseases and controls. These findings suggest that DNase I phenotype 2 may be potentially useful for identifying patients who are at risk of harboring or developing colorectal carcinoma.
Tsutsumi
S
S
First Department of Surgery, Gunma University School of Medicine, Showa-machi, 371-8511, Maebashi, Japan. chuchumi@showa.gunma-u.ac.jp
Takeshita
H
H
Yasuda
T
T
Kuwano
H
H
Kishi
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D003850:Deoxyribonuclease I / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D015151:Immunoblotting; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D007564:Japan; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors
D007527:Isoenzymes; D003850:Deoxyribonuclease I