Collagenolytic protease preparations from invertebrates: experimental study of acute and chronic toxicity.
Toxicity of active matter of new structure-destroying enzyme preparations containing a complex of collagenolytic proteases from invertebrates (Collagenase from hydrobionts, Polycollagenase-K, Fermenkol) was studied. The absence of acute toxicity in skin application is proved, and LD(50) for intraperitoneal administration to mice and rats were determined. A long-term treatment with clinical doses under various types of application does not affect body weight gain, biochemical indices of the plasma, ECG, diuresis, and urine content.
Paramonov
B A
BA
St. Petersburg-Technologiya, St. Petersburg.
Klimova
O A
OA
Chebotarev
V Y
VY
D000818:Animals; D017364:Collagenases / Q000302:isolation & purification* / Q000378:metabolism / Q000633:toxicity; D007448:Invertebrates; D008297:Male; D051379:Mice
D017364:Collagenases