title: Identification of Brucella abortus OxyR and its role in control of catalase expression.
abstract: We report the cloning and sequencing of the Brucella abortus oxyR homolog and provide evidence that the transcription product of this gene binds to the B. abortus catalase promoter region. A gene replacement/deletion Brucella oxyR mutant exhibits increased sensitivity to prolonged exposure to H(2)O(2) and is unable to adapt to H(2)O(2) in the environment.
authors.affiliation: Department of Zoology and Genetics, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Mayfield
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D002003:Brucella abortus / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D002374:Catalase / Q000235:genetics*; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D015971:Gene Expression Regulation, Enzymologic; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D006861:Hydrogen Peroxide; D002374:Catalase