title: Pulmonary function profile in chronic congestive heart failure and the effect of ipratropium bromide.
abstract: Twenty-five symptomatic patients of chronic heart failure were subjected to spirometry to detect abnormalities of pulmonary function and to assess the effect of ipratropium bromide in reversing or minimising these abnormalities. All the patients exhibited abnormal pulmonary function manifesting as obstructive (15/25) or restrictive (10/25) ventilatory defect. There was overall improvement in lung functions with ipratropium bromide especially in those with obstructive ventilatory defects and mostly comprised of smokers. Forced expiratory volume in one second increased by 47.7 percent (p < 0.02), forced expiratory volume in one second/forced vital capacity ratio by 14.1 percent (p < 0.001) and maximal voluntary ventilation by 40.6 percent (p < 0.05) in these patients. It is concluded that ipratropium bromide can prove as a promising adjunctive therapeutic intervention in improving quality of life in patients of chronic congestive heart failure who are incapacitated by dyspnoea and have clearly documented ventilatory defects.
authors.affiliation: Department of Cardiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar.
authors.forename: K A
authors.initials: KA
authors.lastname: Khan
authors.forename: S
authors.initials: S
authors.lastname: Jalal
authors.forename: V M
authors.initials: VM
authors.lastname: Jan
authors.forename: G M
authors.initials: GM
authors.lastname: Lone
authors.forename: R
authors.initials: R
authors.lastname: Jan
authors.forename: M S
authors.initials: MS
authors.lastname: Alai
authors.forename: K
authors.initials: K
authors.lastname: Iqbal
authors.forename: N A
authors.initials: NA
authors.lastname: Tramboo
authors.forename: N A
authors.initials: NA
authors.lastname: Lone
authors.forename: H A
authors.initials: HA
authors.lastname: Rather
authors.forename: M A
authors.initials: MA
authors.lastname: Dar
mesh_terms: D000328:Adult; D000368:Aged; D001993:Bronchodilator Agents / Q000494:pharmacology*; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D009241:Ipratropium / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D015656:Respiratory Mechanics / Q000187:drug effects*; D013147:Spirometry
chemical_list: D001993:Bronchodilator Agents; D009241:Ipratropium