Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii.
The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.
He
W
W
Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
Cik
M
M
Lesage
A
A
Van der Linden
I
I
De Kimpe
N
N
Appendino
G
G
Bracke
J
J
Mathenge
S G
SG
Mudida
F P
FP
Leysen
J E
JE
Van Puyvelde
L
L
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D004224:Diterpenes; D004952:Esters; D019665:Euphorbiaceae / Q000737:chemistry*; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects*; D013057:Spectrum Analysis; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
D004224:Diterpenes; D004952:Esters; D013729:Terpenes; D014315:Triterpenes; C417923:kirkinine; C011309:mezerein