title: Artifact-tolerant controllers for automatic drug delivery in anesthesia.
abstract: This article presents a method for treating measurement artifacts in model-based control systems. A nonlinear modification to the usual observer structure is introduced to prevent the measurement artifacts from winding up the controller states. It is shown how stability of the closed loop system can be analyzed and an example of a successful application in a clinical study is provided.
authors.affiliation: Automatic Control Laboratory, Swiss Federal Institute of Technology (ETH), Zurich.
authors.forename: C W
authors.initials: CW
authors.lastname: Frei
authors.forename: E
authors.initials: E
authors.lastname: Bullinger
authors.forename: A
authors.initials: A
authors.lastname: Gentilini
authors.forename: A H
authors.initials: AH
authors.lastname: Glattfelder
authors.forename: T
authors.initials: T
authors.lastname: Sieber
authors.forename: A M
authors.initials: AM
authors.lastname: Zbinden
mesh_terms: D000465:Algorithms; D000777:Anesthetics / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016477:Artifacts; D001331:Automation; D002138:Calibration; D016503:Drug Delivery Systems / Q000379:methods*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000777:Anesthetics; D007530:Isoflurane