title: Oxygen consumption, carbon dioxide production and lactic acid during normothermic cardiopulmonary bypass.
abstract: The objective of this study was to measure oxygen consumption, carbon dioxide production and lactic acid levels during normothermic cardiopulmonary bypass. A prospective study was undertaken in a tertiary care community hospital, involving 20 adults undergoing cardiopulmonary bypass with prolonged (>65 min) crossclamping of the aorta. O2 consumption, CO2 production, hemoglobin and lactic acid levels were measured 5, 35 and 65 min after crossclamping of the aorta. O2 consumption was 79.7 +/- 14.5, 78.8 +/- 15.4 and 81.5 +/- 14.1 ml/min/m2 at 5, 35 and 65 min after crossclamping the aorta. CO2 production was 61.8 +/- 42.9, 60.6 +/- 26.3 and 62.2 +/- 35.9 ml/min/m2 at the same times. Lactic acid levels were 1.6 +/- 0.5 mM/dl at all three times and did not correlate with O2 consumption or CO2 production. In conclusion, although oxygen consumption was low, there was no evidence of abnormal lactate or anaerobic metabolism to suggest tissue ischemia.
authors.affiliation: Department of Anesthesiology, Saint Vincent Mercy Medical Center, Toledo, Ohio 43608, USA. engoren@pol.net
authors.forename: M
authors.initials: M
authors.lastname: Engoren
authors.forename: M
authors.initials: M
authors.lastname: Evans
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology; D000368:Aged; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D002315:Cardiopulmonary Bypass; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D013696:Temperature; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D002245:Carbon Dioxide; D019344:Lactic Acid; D010100:Oxygen