title: Short communication: effect of pH on absorption of immunoglobulin G in neonatal calves.
abstract: We fed newborn calves (n = 60) maternal colostrum (n = 12) or a colostral supplement product derived from edible bovine serum (n = 48). Sodium citrate was added to supplements to achieve a final pH of 7.5, 7.0, 6.0, and 5.0. Calves were fed colostrum (2 L/feeding) or supplement (454 g reconstituted in 2 L of water) at 1.2 and 12.6 h of age, which provided a total of 156 (colostrum) or 90 (supplement) g of IgG. We sampled jugular blood at 0 and 24 h of age to determine plasma IgG. Mean plasma IgG concentrations at 0 and 24 h of age were 0 and 6.7 g/L and were markedly higher in calves fed maternal colostrum compared with supplements (10.7 vs. 6.5 g/L) and were higher in Jersey vs. Holstein calves (8.5 vs. 6.1 g/L). Estimated apparent efficiency of IgG absorption was unaffected by treatment and averaged 20%. These data indicate that pH of colostral supplements between 7.5 and 5.0 do not markedly influence the efficiency of IgG absorption.
authors.affiliation: Ruminant Products Division, American Protein Corporation, Ames, IA 50010, USA. jim.quigley@amerprotcorp.com
authors.forename: J D
authors.initials: JD
authors.lastname: Quigley
authors.forename: P
authors.initials: P
authors.lastname: French
authors.forename: R E
authors.initials: RE
authors.lastname: James
mesh_terms: D000042:Absorption; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D003126:Colostrum / Q000276:immunology*; D005260:Female; D005526:Food, Formulated; D006863:Hydrogen-Ion Concentration; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D008297:Male; D011897:Random Allocation
chemical_list: D007074:Immunoglobulin G