Synthesis of (3alpha,7beta, 17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer.
The syntheses of the 7beta-hydroxy metabolite of ORG OD14 (Livial), (3alpha,7beta, 17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-t riol (35), and its 7-epimer, (3alpha,7alpha, 17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-t riol (11), are described.
Plate
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Medicinal Chemistry Department, N.V. Organon, The Netherlands. R.Plate@organon.oss.akzonobel.nl
van Wuijtswinkel
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RC
Jans
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CG
Groen
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MB
D045930:Anabolic Agents / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000737:chemistry; D018931:Antineoplastic Agents, Hormonal / Q000138:chemical synthesis / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009652:Norpregnenes / Q000138:chemical synthesis* / Q000737:chemistry*; D051381:Rats
C415602:7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol; D045930:Anabolic Agents; D000959:Antihypertensive Agents; D018931:Antineoplastic Agents, Hormonal; D009652:Norpregnenes; C027385:tibolone