title: The secretion of insulin-like growth factor I, prolactin and insulin-like growth factor binding protein 1 by the decidua as predictors of human fetal growth.
abstract: To determine if in vitro secretion of the decidual peptides insulin-like growth factor I (IGF-I), prolactin or insulin-like growth factor binding protein 1 (IGFBP-1) correlates with infant birthweight in uncomplicated, term human pregnancies, decidua from 45 pregnancies with normally distributed birthweights was cultured in defined medium for 24 h. IGF-I, prolactin and IGFBP-1 concentrations in the culture medium were measured by radioimmunoassay. Neither infant birthweight nor a normalized measure of infant birthweight (birthweight z-score) correlated with the quantity of IGF-I, prolactin or IGFBP-1 secreted by the decidua from that pregnancy. There were no differences in any of the peptide hormones assayed when the pregnancies were grouped by infant sex. IGF-I and prolactin secretion by individual decidual samples correlated positively. IGF-I and IGFBP-1 secretion also correlated positively in individual samples. A previously identified correlation between decidual IGF-I secretion and infant birthweight among a group of normal and growth restricted (IUGR) pregnancies was not confirmed in the current study. These data indicate that the decrease in decidual IGF-I and prolactin secretion seen in IUGR pregnancies is not the hormone profile of the low birthweight end of a normal population, but a distinct endocrine profile.
authors.affiliation: Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. ljheffner@bics.bwh.Harvard.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Heffner
authors.forename: L A
authors.initials: LA
authors.lastname: Benoit
authors.forename: D R
authors.initials: DR
authors.lastname: Clemmons
authors.forename: K C
authors.initials: KC
authors.lastname: Copeland
mesh_terms: D000653:Amniotic Fluid / Q000737:chemistry; D015415:Biomarkers; D001724:Birth Weight; D003656:Decidua / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D009924:Organ Culture Techniques; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I; D011388:Prolactin