title: Standard errors for EM estimates in generalized linear models with random effects.
abstract: A procedure is derived for computing standard errors of EM estimates in generalized linear models with random effects. Quadrature formulas are used to approximate the integrals in the EM algorithm, where two different approaches are pursued, i.e., Gauss-Hermite quadrature in the case of Gaussian random effects and nonparametric maximum likelihood estimation for an unspecified random effect distribution. An approximation of the expected Fisher information matrix is derived from an expansion of the EM estimating equations. This allows for inferential arguments based on EM estimates, as demonstrated by an example and simulations.
authors.affiliation: Institute of Statistics, Technical University Graz, Austria. friedl@stat.tu-graz.ac.at
authors.forename: H
authors.initials: H
authors.lastname: Friedl
authors.forename: G
authors.initials: G
authors.lastname: Kauermann
mesh_terms: D000465:Algorithms; D000704:Analysis of Variance; D001699:Biometry / Q000379:methods; D019992:Databases as Topic; D020407:Internet; D016013:Likelihood Functions; D015233:Models, Statistical; D009010:Monte Carlo Method; D016011:Normal Distribution; D011897:Random Allocation