Mutants yield a pharmacophore model for the tubulin-paclitaxel binding site.
Day
B W
BW
Departments of Environmental and Occupational Health and of Pharmaceutical Sciences, University of Pittsburgh, 260 Kappa Drive, Pittsburgh, PA 15238, USA. bday1@pitt.edu
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism*; D001665:Binding Sites; D006801:Humans; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D017239:Paclitaxel / Q000378:metabolism*; D011955:Receptors, Drug / Q000235:genetics* / Q000378:metabolism*; D014404:Tubulin / Q000235:genetics* / Q000378:metabolism*
D000972:Antineoplastic Agents, Phytogenic; D011955:Receptors, Drug; D014404:Tubulin; D017239:Paclitaxel