title: Persistent asthma: patient characteristics, courses of asthma, and utility of salmeterol.
abstract: Applications of National Asthma and Education and Prevention Program (NAEPP) guidelines for the diagnosis and management of asthma may reduce the morbidity of this disorder. Medical records and questionnaires from a series of 177 outer-city adolescents and adults with persistent asthma were audited according to NAEPP guidelines and for utility of salmeterol (Serevent). Allergic sensitivity and exposure to indoor allergens house-dust mite (66% of patients), fungi (42%), cat (20%) and/or dog (14%) were of dominant importance to persistent asthma. Patients who continued salmeterol over 1 year had reduced severity of disease, improved forced expiratory flow at 25%-75% of vital capacity, and reduced usage of systemic, but not inhaled, corticosteroid.
authors.affiliation: Division of Allergy, Asthma and Immunology Scripps Clinic, La Jolla, California 92037, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Mathison
authors.forename: J A
authors.initials: JA
authors.lastname: Koziol
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000420:Albuterol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002415:Cats; D002648:Child; D004285:Dogs; D005260:Female; D005540:Forced Expiratory Flow Rates; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D008925:Mites; D012130:Respiratory Hypersensitivity / Q000276:immunology; D000068299:Salmeterol Xinafoate; D011795:Surveys and Questionnaires; D014797:Vital Capacity
chemical_list: D000485:Allergens; D001993:Bronchodilator Agents; D000068299:Salmeterol Xinafoate; D000420:Albuterol