title: Disc degeneration: a human cadaveric study correlating magnetic resonance imaging and quantitative discomanometry.
abstract: METHODS
  This human cadaveric study evaluated disc degeneration of the lumbar spine using magnetic resonance imaging and quantitative discomanometry.
  
  
  OBJECTIVE
  To determine if a correlation exists between magnetic resonance imaging and quantitative discomanometry in determining disc degeneration of the lumbar spine.
  
  
  BACKGROUND
  Several studies analyzing disc degeneration of the lumbar spine have compared magnetic resonance imaging with discography and discomanometry. The reported results are conflicting. No studies exist that compare magnetic resonance imaging and quantitative discomanometry in assessing the disc degeneration of the lumbar spine.
  
  
  METHODS
  Three fresh human cadaveric thoracolumbar spine specimens (two T11-S1 and one L1-S1) that included a total of 19 discs were used. Spines were scanned with magnetic resonance imaging, and the scans were read by a neuroradiologist. Using the quantitative discomanometry technique, discs were injected with normal saline, and pressure-volume curves were collected and quantified with six parameters: intrinsic pressure, leakage pressure, initial slope, slope from 0.0 to 0.1 mL, maximum pressure, and volume at maximum pressure. Data analysis was performed using Spearman's Rank Correlation (Rho) statistic.
  
  
  RESULTS
  Based on the results from 19 discs, an overall good correlation between magnetic resonance imaging scores and the six quantitative discomanometry parameters was demonstrated. With exception of the volume at maximum pressure, correlation coefficients ranged between 0.61 to 0.78 with a P < 0.05.
  
  
  CONCLUSIONS
  Magnetic resonance imaging scores and quantitative discomanometry parameters correlated well in the assessment of disc degeneration of the lumbar spine. Quantitative discomanometry may be an important technique for evaluating early disc degeneration, especially tears of the anular fibers, which may be missed on magnetic resonance imaging.
authors.affiliation: Memorial Orthopaedic Surgical Group, Long Beach, California, USA.
authors.forename: E P
authors.initials: EP
authors.lastname: Southern
authors.forename: M A
authors.initials: MA
authors.lastname: Fye
authors.forename: M M
authors.initials: MM
authors.lastname: Panjabi
authors.forename: T C
authors.initials: TC
authors.lastname: Patel
authors.forename: J
authors.initials: J
authors.lastname: Cholewicki
mesh_terms: D000368:Aged; D002102:Cadaver; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology* / Q000503:physiopathology*; D007405:Intervertebral Disc Displacement / Q000473:pathology* / Q000503:physiopathology*; D008159:Lumbar Vertebrae / Q000473:pathology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008365:Manometry