Headspace gas chromatographic determination of 1,3-butadiene in simulated saliva.
A headspace gas chromatographic (GC) method was developed to determine 1,3-butadiene (1,3-BD) in simulated saliva in contact with chewing gum. The calibration graph was linear, and the limit of detection was 0.004 mg/L, which is well below the migration limit for this substance. The headspace GC method provides rapid and reliable analysis for monitoring 1,3-BD migration from chewing gum into simulated saliva. In this paper, we report headspace methodology for sensitive determination of 1,3-BD in chewing gum and results of selected analyses, enabling preliminary assessment of possible exposure to 1,3-BD through migration.
Abrantes
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Instituto Nacional de Controle de Qualidade em Saúde, Departamento de Química, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Dos Santos
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TC
Simões
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G
Abrantes
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S
Dos Santos
T C
TC
Simões
G
G
D002070:Butadienes / Q000032:analysis* / Q000737:chemistry; D002638:Chewing Gum / Q000032:analysis; D002849:Chromatography, Gas / Q000379:methods*; D011786:Quality Control; D012463:Saliva / Q000737:chemistry*; D012680:Sensitivity and Specificity
D002070:Butadienes; D002638:Chewing Gum; C031763:1,3-butadiene