The effects of KRN5500, a spicamycin derivative, on neuropathic and nociceptive pain models in rats.
We studied the effects of a spicamycin derivative, KRN5500, on two animal models of neuropathic pain (Chung and Bennett models) and a nociceptive pain model by using Complete Freund's adjuvant. After the establishment of mechanical allodynia by using the previously mentioned models, a single intraperitoneal injection of KRN5500 produced significant attenuation of mechanical allodynia in both neuropathic pain models. However, this effect was not observed in rats that had a nociceptive injury (Complete Freund's adjuvant). Furthermore, this experimental drug did not alter the mechanical pain threshold (by using von Frey filament test) on normal, uninjured rats. We have demonstrated that KRN5500 may have value in the treatment of neuropathic pain.
Abdi
S
S
Department of Anesthesia and Critical Care, Center for Functional Pain Neuroimaging and Therapy Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129-2060, USA.
Vilassova
N
N
Decosterd
I
I
Feroz
N
N
Borsook
D
D
D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006614:Hindlimb; D007274:Injections, Intraperitoneal; D008297:Male; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D017288:Pain Threshold / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D010919:Placebos; D011684:Purine Nucleosides / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020426:Sciatic Neuropathy / Q000150:complications*; D016037:Single-Blind Method; D013127:Spinal Nerves
D000700:Analgesics; D000903:Antibiotics, Antineoplastic; D010919:Placebos; D011684:Purine Nucleosides; C092296:KRN 5500; D005620:Freund's Adjuvant