Mechanism of homophilic cadherin adhesion.
Direct measurements of the distance-dependent forces between membrane-bound cadherins were used to test current models of homophilic cadherin interactions. The results reveal a complex binding mechanism in which the proteins adhere in multiple alignments that involve more than the amino-terminal domains.
Leckband
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Department of Chemical Engineering, University of Illinois, Urbana, Illinois 61801, USA. leckband@uiuc.edu
Sivasankar
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D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D002448:Cell Adhesion / Q000502:physiology*; D019281:Dimerization; D008854:Microscopy, Electron; D008958:Models, Molecular; D011487:Protein Conformation
D015820:Cadherins