Solid-phase synthesis of 4-substituted imidazoles using a scaffold approach.
Immobilized 4-iodoimidazole 2 was used in a metal/halogen exchange reaction followed by treatment with electrophiles and subsequent cleavage from the resin to yield 4-substituted imidazoles 8-11. Grignard reaction with the resin-bound ketones 5 yielded the corresponding alcohols 11. This approach was used for a library synthesis of 35 imidazoles.
Gelens
E
E
Leiden/Amsterdam Center for Drug Research (LACDR), Department of Pharmacochemistry, Vrije Universiteit, Amsterdam, The Netherlands.
Koot
W J
WJ
Menge
W M
WM
Ottenheijm
H C
HC
Timmerman
H
H
D007093:Imidazoles / Q000138:chemical synthesis*
D007093:Imidazoles