C-type natriuretic peptide: an important neuroendocrine regulator?
In the decade since its discovery, C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, has been shown to be produced by most of the major endocrine glands, including the hypothalamus and anterior pituitary. The relative abundance of its guanylyl cyclase-containing GC-B receptor in these glands suggests that CNP might be a local neuroendocrine regulator. Here, we review this possibility, emphasizing signalling and integration with other regulatory systems in the neuroendocrine control of reproduction.
Fowkes
R C
RC
Department of Clinical Biochemistry, St Bartholomew's and the Royal London School of Medicine and Dentistry, West Smithfield, London, UK EC1A 7BE. r.c.fowkes@mds.qmw.ac.uk
McArdle
C A
CA
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D020098:Natriuretic Peptide, C-Type / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D013045:Species Specificity
D020098:Natriuretic Peptide, C-Type