title: Specific genetic diseases at risk for sedation/anesthesia complications.
abstract: We reviewed of a number of genetic diseases known or at risk for sedation or anesthesia complications. Some of these conditions are relatively common (e.g., Down's syndrome) whereas others are rare or present with multiple congenital anomalies that have an impact on health care delivery. We listed complications, recommended presedation evaluations, and included checklist items to assist the health care provider administering sedation and anesthesia. A better recognition and awareness of risk factors associated with specific genetic diseases should lessen the likelihood of complications during these procedures.
  
  
  CONCLUSIONS
  This article provides a brief description of potential problematic genetic disorders and associated complications that may manifest during sedation or anesthesia. Recommendations for presedation evaluation and checklist items are given that may impact on the delivery of care for these patients.
authors.affiliation: Section of Medical Genetics and Molecular Medicine, Children's Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA. mgbutler@cmh.edu
authors.forename: M G
authors.initials: MG
authors.lastname: Butler
authors.forename: B G
authors.initials: BG
authors.lastname: Hayes
authors.forename: M M
authors.initials: MM
authors.lastname: Hathaway
authors.forename: M L
authors.initials: ML
authors.lastname: Begleiter
mesh_terms: D000015:Abnormalities, Multiple / Q000503:physiopathology; D000777:Anesthetics / Q000009:adverse effects*; D004314:Down Syndrome / Q000503:physiopathology; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D010347:Patient Care Planning; D012307:Risk Factors
chemical_list: D000777:Anesthetics; D006993:Hypnotics and Sedatives