BSPRY, a novel protein of the Ro-Ret family.
Utilizing the yeast two-hybrid system we have identified a novel protein of the Ro-Ret family that was termed BSPRY. This protein is composed of a B-box, an alpha-helical coiled coil and a SPRY domain. BSPRY from human beings shares 80% sequence identity with the homologous protein from mice. The gene for BSPRY resides on human chromosome 9 and is specifically expressed in testis. It comprises six exons and five introns and possesses a GC rich promoter forming a typical CpG island. The function of BSPRY is not known, but several related proteins of the RBCC family have been implicated in cell transformation.
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M.E. Müller-Institute, P.O. Box 30, University of Bern, CH-3010, Bern, Switzerland.
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D000595:Amino Acid Sequence; D000818:Animals; D016384:Consensus Sequence; D005091:Exons; D006801:Humans; D007438:Introns; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D017385:Sequence Homology; D013737:Testis / Q000378:metabolism*; D015003:Yeasts / Q000235:genetics
C416225:BSPRY protein, human; D011506:Proteins