New antimicrobial flavanones from Physena madagascariensis.
Two new flavanones (1 and 2) with antibacterial activity were isolated from the methanolic extract of the dried leaves of Physena madagascariensis using activity against Staphylococcus aureus to guide the isolation. A third flavonoid, a flavanone dimer linked by a methylene group (3) was also isolated and proved to be inactive. The structures of 1 and 2 were established primarily from NMR studies, while that of 3 required more extensive mass spectrometric analysis. All three flavanones had lavandulyl units in the limonene form. Flavanones 1 and 2 were active against several bacteria at concentrations as low as 4 microM.
Deng
Y
Y
Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
Lee
J P
JP
Tianasoa-Ramamonjy
M
M
Snyder
J K
JK
Des Etages
S A
SA
Kanada
D
D
Snyder
M P
MP
Turner
C J
CJ
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002850:Chromatography, Gel; D002942:Circular Dichroism; D044950:Flavanones; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D008270:Madagascar; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014197:Trees / Q000737:chemistry
D000900:Anti-Bacterial Agents; D044950:Flavanones; D005419:Flavonoids; C414434:remangiflavanone A; C414435:remangiflavanone B