oCRF and CRF (6-33) depress food but not water intake in the obese Zucker rat.
It has previously been demonstrated that oCRF and the CRF binding protein inhibitor CRF (6-33) reduce body-weight gain in obese Zucker rats. We investigated whether the reduction in body-weight is attributable to altered feeding and drinking behaviour. Obese Zucker rats were fitted with osmotic mini-pumps connected to i.c.v. cannulas. Vehicle, oCRF (5 microg/day) or CRF (6-33) (25 microg/day) were infused for 7 days and the animals observed for an additional 7 days. Body-weight and food and water-intake were recorded daily at 14.00 h. In agreement with published results, oCRF and CRF (6-33) significantly reduced body-weight gain in the obese Zucker rat. In addition, food intake was reduced, whereas water consumption was unaffected.
Bjenning
C A
CA
Health Care Discovery and Preclinical Development, Novo Nordisk, Måløv, Denmark. cbjg@novo.dk
Rimvall
K
K
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011924:Rats, Zucker; D012756:Sheep; D015430:Weight Gain / Q000187:drug effects
D010446:Peptide Fragments; D003346:Corticotropin-Releasing Hormone