[Does TNF-alpha contribute to liver disease physiopathology?].
The aim of the present paper is to establish the possible role of serum TNF in the pathophysiology of three experimental models of liver injury: paracetamol intoxication, cholestasis followed by paracetamol intoxication and cholestasis. We concluded that under our experimental conditions the serum TNF-alpha levels were not responsible for the inflammatory phenomena described in our previous paper as apoptosis.
Ghanem
C
C
Cátedra de Fisiopatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires.
Ghisolfi
C
C
Scorticati
C
C
Lemberg
A
A
Perazzo
J C
JC
Bengochea
L
L
D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000139:chemically induced* / Q000503:physiopathology; D007674:Kidney Diseases / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry / Q000502:physiology*
D018712:Analgesics, Non-Narcotic; D014409:Tumor Necrosis Factor-alpha; D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin