title: Serum leptin and vascular risk factors in obstructive sleep apnea.
abstract: OBJECTIVE
  To define the metabolic profile relevant to vascular risks in obstructive sleep apnea (OSA) and the role of leptin resistance in this risk profile.
  
  
  METHODS
  Case control study.
  
  
  METHODS
  Sleep Laboratory, Queen Mary Hospital, University of Hong Kong, China.
  
  
  METHODS
  Thirty OSA subjects were matched with 30 non-OSA subjects for body mass index (BMI), age, sex, and menopausal status. Neck, waist, and hip girth, skinfold thickness, and fasting serum levels of lipids, glucose, insulin, and leptin were compared between these two groups.
  
  
  RESULTS
  Compared with control subjects with a similar BMI but without OSA, the OSA group had a significantly more adverse vascular risk factor profile, including dyslipidemia, higher diastolic BP, insulin resistance, and greater adiposity reflected by skinfold thickness. OSA subjects also had higher circulating leptin levels (9.18+/-4.24 ng/mL vs 6.54+/-3.81 ng/mL, mean +/- SD, p = 0.001). Serum leptin levels correlated positively with BMI, skinfold thickness, serum cholesterol, low-density lipoprotein cholesterol, insulin, insulin/glucose ratio, apnea-hypopnea index, and oxygen desaturation time; multiple stepwise regression analysis identified skinfold thickness, waist/hip ratio, serum low-density lipoprotein cholesterol, and diastolic BP as independent correlates, while only serum insulin and diastolic BP were independent correlates in OSA subjects. After treatment with nasal continuous positive airway pressure for 6 months, there was a significant decrease in circulating leptin (p = 0.01) and triglyceride levels (p = 0.02) without change in other parameters.
  
  
  CONCLUSIONS
  Despite controlling for BMI, OSA subjects showed distinct profiles with clustering of vascular risk factors. Hyperleptinemia was present in the OSA subjects, but it can be normalized by treatment with nasal continuous positive airway pressure, suggesting that increased leptin resistance was not the cause of OSA or its associated vascular risks.
authors.affiliation: Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China. msmip@hkucc.hku.hk
authors.forename: M S
authors.initials: MS
authors.lastname: Ip
authors.forename: K S
authors.initials: KS
authors.lastname: Lam
authors.forename: C
authors.initials: C
authors.lastname: Ho
authors.forename: K W
authors.initials: KW
authors.lastname: Tsang
authors.forename: W
authors.initials: W
authors.lastname: Lam
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D011175:Positive-Pressure Respiration; D011863:Radioimmunoassay; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications* / Q000628:therapy; D014652:Vascular Diseases / Q000097:blood / Q000209:etiology* / Q000517:prevention & control
chemical_list: D015415:Biomarkers; D020738:Leptin