title: Quantitative measurement of neurologic impairment in patients with multiple sclerosis.
abstract: Eleven patients with clinically diagnosed multiple sclerosis were simultaneously evaluated with history, physical, and neurologic evaluations and a series of objective neurophysiologic tests. Patients were then scored independently on clinical stage of their disease using a system based on symptoms in history or findings on physical or neurologic examination. Test scores on objective tests were compared with clinical scores with each evaluator. Patients with high test scores on clinical evaluation usually had high test scores on objective testing. Symptoms and physical findings were then correlated with abnormalities on objective tests. Objective abnormalities in visual evoked response and auditory evoked response on several occasions preceded the development of symptoms. All patients except for two had more than one abnormality on objective testing, suggesting a high likelihood that objective tests are helpful in the diagnosis of early-stage multiple sclerosis.
authors.affiliation: Division of Otolaryngology, Southern Illinois University School of Medicine, Springfield 62702, USA.
authors.forename: H R
authors.initials: HR
authors.lastname: Konrad
authors.forename: D C
authors.initials: DC
authors.lastname: Good
authors.forename: A B
authors.initials: AB
authors.lastname: Devleschoward
mesh_terms: D005072:Evoked Potentials, Auditory / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D006801:Humans; D009103:Multiple Sclerosis / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology; D009460:Neurologic Examination / Q000706:statistics & numerical data*; D011237:Predictive Value of Tests; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology