T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines.
The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites.
Agace
W W
WW
Immunology Section, Department of Cell and Molecular Biology, Lund University, Sweden.
Higgins
J M
JM
Sadasivan
B
B
Brenner
M B
MB
Parker
C M
CM
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002450:Cell Communication; D018925:Chemokines / Q000378:metabolism; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D011485:Protein Binding; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*
D015820:Cadherins; D015815:Cell Adhesion Molecules; D018925:Chemokines; D016023:Integrins; C120427:LEEP-CAM protein, human; D008562:Membrane Glycoproteins; C070709:integrin alphaEbeta7