title: The genetics of osteoporosis. Future diagnostic possibilities.
abstract: The risk of developing osteoporosis is determined by the interaction of several mostly unknown genes and environmental factors. Genetic studies in osteoporosis have largely focussed on association studies of a small number of candidate genes, with few linkage studies performed, and large areas of the genome remaining unexplored. Identifying the genes involved in osteoporosis would be a major advance in our understanding of the causation of the disease, and lead to advances in diagnosis, risk prediction, and potentially preventive and therapeutic measures.
authors.affiliation: Wellcome Trust Centre for Human Genetics, Headington, Oxford, England. mbrown@well.ox.ac.uk
authors.forename: M A
authors.initials: MA
authors.lastname: Brown
authors.forename: J A
authors.initials: JA
authors.lastname: Eisman
mesh_terms: D002874:Chromosome Mapping; D008040:Genetic Linkage; D006801:Humans; D015810:Linkage Disequilibrium; D010024:Osteoporosis / Q000175:diagnosis* / Q000235:genetics*; D010641:Phenotype