Striatal dopamine release in reading and writing measured with [123I]iodobenzamide and single photon emission computed tomography in right handed human subjects.
Competition between endogenous dopamine and a radioligand for postsynaptic dopamine D(2) receptor binding was examined in two groups of eight subjects each who had to read or write off a text, respectively, and in a control group. Single photon emission computed tomography (SPECT) and the ligand [(123)I]iodobenzamide (IBZM) were used for in vivo imaging. Subjects commenced reading or writing immediately before IBZM injection and continued for 30min thereafter. SPECT images were acquired 60min later. Striatum-to-parietal-cortex IBZM uptake ratios were lower in subjects who wrote off the text than in controls indicating competition of IBZM and dopamine. There was no difference between subjects who read the text and controls. Thus, dopamine release occurs as a consequence of the motoric activity involved in writing rather than of cognitive functions necessary for reading the text.
Schommartz
B
B
Department of Nuclear Medicine, Heinrich-Heine-Universität, Moorenstrasse 5, 40225, Düsseldorf, Germany.
Larisch
R
R
Vosberg
H
H
Müller-Gärtner
H M
HM
D000367:Age Factors; D001549:Benzamides / Q000008:administration & dosage; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D011759:Pyrrolidines / Q000008:administration & dosage; D011932:Reading; D017448:Receptors, Dopamine D2 / Q000502:physiology; D012737:Sex Factors; D015899:Tomography, Emission-Computed, Single-Photon; D014956:Writing
D001549:Benzamides; D007457:Iodine Radioisotopes; D011759:Pyrrolidines; D017448:Receptors, Dopamine D2; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide; D004298:Dopamine