title: Serum levels of high-density lipoprotein phospholipids correlate inversely with severity of angiographically defined coronary artery disease.
abstract: In an attempt to assess the relationship between lipid abnormalities and severity of coronary artery disease, we measured serum levels of cholesterol (SC), triglycerides (TG), phospholipids (SP), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C), and high density lipoprotein phospholipids (HDL-P), in 217 men undergoing diagnostic coronary arteriography. We found significantly higher mean values of HDL-P and HDL-C in men with normal coronaries, but no significant differences in the other measured lipids. While there was no significant difference in HDL-C among patients with one, two or three-vessel disease, there was a negative correlation between HDL-P levels and the severity of the disease. These observations suggest that prospective studies would be of merit to establish the relevance of HDL-P in the development of coronary artery disease.
authors.affiliation: The Department of Dermatology and Cutaneous Surgery, Veterans' Affairs Medical Center, Medical and Research Services, University of Miami School of Medicine, PO Box 016250 R-250, Miami, FL 33101, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lan Hsia
authors.forename: R
authors.initials: R
authors.lastname: Duncan
authors.forename: A H
authors.initials: AH
authors.lastname: Schob
authors.forename: S C
authors.initials: SC
authors.lastname: Chakko
authors.forename: R
authors.initials: R
authors.lastname: Mulingtapang
authors.forename: J L
authors.initials: JL
authors.lastname: He
authors.forename: G O
authors.initials: GO
authors.lastname: Perez
mesh_terms: D002784:Cholesterol; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D010743:Phospholipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol