Effect of pineal tetrapeptide on antioxidant defense in Drosophila melanogaster.
Effects of synthetic pineal tetrapeptide L-Ala-L-Glu-L-Asp-L-Glu (Epithalon) on specific catalase activity and the content of conjugated hydroperoxides in highly inbred Drosophila melanogaster lines differing in reproductive functions were studied. It was shown that Epithalon is a potent modulator of the antioxidant defense, whose biological activity 1000-fold surpasses that of the complex pineal peptide preparation Epithalamin.
Khavinson
V K
VK
St. Petersburg Institute of Biological Regulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences.
Myl'nikov
S V
SV
D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002374:Catalase / Q000502:physiology; D004331:Drosophila melanogaster / Q000502:physiology; D005609:Free Radicals; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology
D000975:Antioxidants; D005609:Free Radicals; D010455:Peptides; C027437:epithalamin; D002374:Catalase