Crystallization of lactose from carbopol gels.
OBJECTIVE
To crystallize lactose under static conditions with a view to preparing crystals of well-defined morphology.


METHODS
et-Lactose monohydrate was crystallized from neutralized Carbopol 934 gels. When the majority of crystals had grown to maturity, the gels were acidified using diluted hydrochloric acid and the crystals were harvested by filtration or centrifugation and washed with ethanol-water mixtures.


RESULTS
Crystals prepared from the gel had a consistently narrower size distribution than control crystals, prepared from solution under constant stirring. If crystallization was effected in the gel without sedimentation of the crystals, then the resultant crystals had smooth surfaces without visually detectable surface roughness or asperities viewed by optical microscopy. The crystals from Carbopol gels also exhibited the uniform shape of an elongated tomahawk regardless of the crystallization conditions, in contrast to crystallization under constant stirring, where the crystal shape of lactose changed with crystallization conditions especially as a function of the initial concentration of lactose. All batches of lactose crystals prepared from Carbopol gels existed as alpha-lactose monohydrate, which showed better flowability than the controls of a similar particle size.


CONCLUSIONS
Crystallization from Carbopol gel produces lactose crystals of uniform size, regular shape, smooth surface, and improved flowability.
Zeng
X M
XM
Department of Pharmacy, King's College London, UK.
Martin
G P
GP
Marriott
C
C
Pritchard
J
J
D000180:Acrylic Resins; D003460:Crystallization; D004337:Drug Carriers; D005782:Gels; D007785:Lactose / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*
D000180:Acrylic Resins; D004337:Drug Carriers; D005782:Gels; D011145:Polyvinyls; C006912:carboxypolymethylene; D007785:Lactose