title: Acute eosinophilic myocarditis in a young woman.
abstract: The first stage of eosinophilic myocarditis is called the necrotizing phase. This stage of eosinophilic myocarditis of unknown cause is often fulminant and rapidly fatal, occurring predominantly in males. Here, we report a case of eosinophilic myocarditis in the acute necrotizing phase occurred without known cause in a 23-year-old Japanese female. Severe diffuse hypokinesis of the left ventricular wall motion (ejection fraction 19.3%), significant concentric edematous thickening of the left ventricular wall (20.1 mm in diastole) and a moderate amount of pericardial effusion (10 mm wide echo free space posteriorly) were revealed by echocardiography. Eosinophils were observed and degranulated eosinophilic cationic proteins were stained with antibody against eosinophilic cationic proteins (EG2) in the myocardial specimens obtained by myocardial biopsy. In spite of its severity, the disease resolved promptly with steroid therapy.
authors.affiliation: Department of Cardiology, National Sagamihara Hospital, Sagamihara City, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Uchino
authors.forename: M
authors.initials: M
authors.lastname: Fukuoka
authors.forename: N
authors.initials: N
authors.lastname: Kawasaki
authors.forename: M
authors.initials: M
authors.lastname: Nakamaru
authors.forename: H
authors.initials: H
authors.lastname: Ochiai
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Umemura
mesh_terms: D000208:Acute Disease; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D004562:Electrocardiography; D047091:Eosinophil Granule Proteins; D004802:Eosinophilia / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009205:Myocarditis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D009336:Necrosis; D011239:Prednisolone / Q000008:administration & dosage; D012260:Ribonucleases
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D011239:Prednisolone; D012260:Ribonucleases