title: Treating acute exacerbations of chronic bronchitis in the face of antibiotic resistance.
abstract: Antibiotics can be effective against acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease, but with bacterial resistance to multiple antibiotics increasing worldwide, appropriate antibiotic selection is critical. Categorizing patients with acute exacerbations according to age, number of exacerbations per year, disease severity, degree of pulmonary impairment, and presence of comorbid conditions helps to direct therapy.
authors.affiliation: Department of Medicine, University of Texas Health Science Center at San Antonio, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Adams
authors.forename: A
authors.initials: A
authors.lastname: Anzueto
mesh_terms: D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001991:Bronchitis / Q000188:drug therapy* / Q000382:microbiology*; D002908:Chronic Disease; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000382:microbiology; D012720:Severity of Illness Index; D013753:Tetracycline Resistance; D014296:Trimethoprim Resistance; D018440:beta-Lactam Resistance
chemical_list: D000900:Anti-Bacterial Agents