Increases in Fos-immunoreactivity after exposure to a combination of two male urinary components in the accessory olfactory bulb of the female rat.
Exposure to either the dialyzed urine preparation (<500 Da) or the remaining substances (>500 Da) did not induce expression of Fos-immunoreactive cells in the mitral/tufted cell layer of the accessory olfactory bulb (AOB), whereas exposure to a mixture of these preparation did induce expression. These results suggest that a combination of low and high molecular weight substances is necessary for the increases in Fos-immunoreactivity in the AOB.
Yamaguchi
T
T
Graduate School of Pharmaceutical Sciences, Hokkaido University, 060-0812, Sapporo, Japan.
Inamura
K
K
Kashiwayanagi
M
M
D000818:Animals; D005260:Female; D008297:Male; D008970:Molecular Weight; D009830:Olfactory Bulb / Q000187:drug effects / Q000378:metabolism*; D010675:Pheromones / Q000502:physiology* / Q000652:urine*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D012965:Sodium Chloride / Q000494:pharmacology; D019147:Vomeronasal Organ / Q000502:physiology
D010675:Pheromones; D016760:Proto-Oncogene Proteins c-fos; D012965:Sodium Chloride