title: [Does TNF-alpha contribute to liver disease physiopathology?].
abstract: The aim of the present paper is to establish the possible role of serum TNF in the pathophysiology of three experimental models of liver injury: paracetamol intoxication, cholestasis followed by paracetamol intoxication and cholestasis. We concluded that under our experimental conditions the serum TNF-alpha levels were not responsible for the inflammatory phenomena described in our previous paper as apoptosis.
authors.affiliation: Cátedra de Fisiopatología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires.
authors.forename: C
authors.initials: C
authors.lastname: Ghanem
authors.forename: C
authors.initials: C
authors.lastname: Ghisolfi
authors.forename: C
authors.initials: C
authors.lastname: Scorticati
authors.forename: A
authors.initials: A
authors.lastname: Lemberg
authors.forename: J C
authors.initials: JC
authors.lastname: Perazzo
authors.forename: L
authors.initials: L
authors.lastname: Bengochea
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000410:Alanine Transaminase / Q000097:blood; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002779:Cholestasis / Q000139:chemically induced* / Q000503:physiopathology; D007674:Kidney Diseases / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry / Q000502:physiology*
chemical_list: D018712:Analgesics, Non-Narcotic; D014409:Tumor Necrosis Factor-alpha; D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin