Myofibroblastic sarcoma of the pleura in a pig.
An intrathoracic sarcoma from a 7-month-old female pig was studied by light and electron microscopy and immunohistochemistry. The tumor tissue of varied cell density consisted chiefly of spindle-shaped cells, some of which grew around blood vessels in a concentric fashion. Many tumor cells were positive for alpha smooth muscle actin and not for desmin, though some cells were reactive for both antigens. A majority of tumor cells had ultrastructural features characteristic of myofibroblasts, but a few cells resembled vascular smooth muscle cells in the synthetic state. This neoplasm may have arisen from vascular smooth muscle with features indicating a transition to myofibroblasts.
Kubota
Y
Y
Higashihiroshima Livestock Hygiene Service Center, Japan.
Ishikawa
Y
Y
Shibahara
T
T
Kadota
K
K
D000818:Animals; D017809:Fatal Outcome; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D007150:Immunohistochemistry / Q000662:veterinary; D008854:Microscopy, Electron / Q000662:veterinary; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010997:Pleural Neoplasms / Q000473:pathology / Q000662:veterinary*; D012509:Sarcoma / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000473:pathology*