title: Two-time window and multiangle photon correlation spectroscopy size and zeta potential analysis--highly sensitive rapid assay for dispersion stability.
abstract: Polysaccharide-stabilized iron oxide particles are highly potent contrast agents in magnetic resonance imaging. After intravenous injection, the size of these small or ultrasmall particles strongly influences their distribution in the body. Knowledge about the uniformity of particle size distribution within this particle size range is not accessible by laser diffraction (lower edge of detection range), and photon correlation spectroscopy (PCS) data only yield insufficient information, the so-called polydispersity index. A combination of two-time window and multiangle analysis makes detailed characterization of particle size distribution and particle aggregation feasible, which was shown using five different iron oxide dispersions. Additional particle charge characterization yielded conclusions about the type of stabilization present in the dispersion - electrostatic or steric stabilization. Thus, this thorough particle size and charge analysis is a tool for quick detection of broad particle distributions or aggregates.
authors.affiliation: Institut für Diagnostikforschung GmbH (IDF) an der Freien Universität Berlin, Spandauer Damm 130, D-14050 Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Thode
authors.forename: R H
authors.initials: RH
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Kresse
mesh_terms: D005290:Ferric Compounds / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010316:Particle Size; D017785:Photons
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide