Diffusion and fate of intramuscularly injected human rabies immune globulin.
The importance of rabies immune globulin (RIG) in postexposure rabies treatment is well known and it has been emphasized that the local injection into the animal bite sites is crucial. This preliminary study used a radioisotope tracer that allows following the fate of human rabies immune globulin (HRIG) injected intramuscularly. There was significant retention and local diffusion of the immune globulin at the injection site and significant radiotracer could still be detected at the site 24 h later.
Saesow
N
N
Division of Nuclear Medicine, Departments of Radiology, Chuialongkorn University Hospital and the Queen Saovabha Memorial Institute, Thai Red Cross Society, 1871 Rama IV Road, 10330, Bangkok, Thailand.
Chaiwatanarat
T
T
Mitmoonpitak
C
C
Wilde
H
H
D000818:Animals; D000914:Antibodies, Viral / Q000008:administration & dosage*; D016903:Drug Monitoring; D006801:Humans; D007114:Immunization; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000378:metabolism; D007273:Injections, Intramuscular; D007668:Kidney / Q000000981:diagnostic imaging; D011817:Rabbits; D011820:Rabies virus / Q000276:immunology*; D011877:Radionuclide Imaging; D013667:Technetium; D013848:Thigh / Q000000981:diagnostic imaging; D013997:Time Factors; D001743:Urinary Bladder / Q000000981:diagnostic imaging
D000914:Antibodies, Viral; D007136:Immunoglobulins; D013667:Technetium