Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric hip fractures.
Of 163 patients with intertrochanteric hip fractures 87 received 2 g dicloxacillin and 240 mg of gentamicin preoperatively, and 76 patients had no antibiotic prophylaxis. Preoperative antibiotic prophylaxis was not shown to have any significant effect on wound infections. However, 16 reversible and 1 irreversible cases of kidney toxicity were found among patients receiving antibiotic prophylaxis, whereas there were only four cases of reversible kidney damage among the patients not receiving antibiotics.
Solgaard
L
L
Department of Orthopaedics, H:S Hvidovre Hospital, Hvidovre, Denmark. solgaard_lars@hotmail.com
Tuxoe
J I
JI
Mafi
M
M
Due Olsen
S
S
Toftgaard Jensen
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D019072:Antibiotic Prophylaxis; D003404:Creatinine / Q000097:blood; D004009:Dicloxacillin / Q000009:adverse effects*; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006620:Hip Fractures / Q000601:surgery*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000009:adverse effects*; D011300:Preoperative Care; D012044:Regression Analysis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D003404:Creatinine; D004009:Dicloxacillin