N-substituted 3-(arylamino)-4,5-dihydro-2H-benz[g]indazol-2-yl acetamides with anti-inflammatory and analgesic activities.
A series of substituted 3-(arylamino)-4,5-dihydro-2H-benz[g]indazol-2-yl acetamides was synthesized and tested in comparison with former analogues. The title compounds showed only weak antiarrhythmic properties but good anti-inflammatory and antinociceptive activity, particularly evident in the morpholino derivative.
Schenone
S
S
Dipartimento di Scienze Farmaceutiche dell'Università di Genova, Italy. bondabsr@unige.it
Bruno
O
O
Ranise
A
A
Bondavalli
F
F
Falcone
G
G
Filippelli
W
W
Rivaldi
B
B
D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology*; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D051381:Rats
D000081:Acetamides; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal