Kinetics of procaterol auto-oxidation in buffered acid solutions.
The kinetics of procaterol (1) degradation in buffered acidic solutions (pH 4-6) was investigated using an HPLC procedure. The effect of temperature and ferric ions on the reaction rate was estimated. In acidic solutions, 1 undergoes pseudo first-order degradation with an induction period. The first-order rate constant for degradation increased and the induction period decreased with an increase in pH. Ferric ions catalyzed the degradation reaction and decreased the induction period. At pH 6, the activation energy of the reaction was 34.5 kcal/mol/deg. The results of this study indicate that 1 in solution is more stable at acidic pH, in the absence of heavy metal ions, and protected from air.
Chen
T
T
Analytical Development Laboratories, Warner-Lambert/Parke-Davis Pharmaceutical Research, Morris Plains, NJ 07950, USA.
Chafetz
L
L
D001993:Bronchodilator Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D017265:Procaterol / Q000737:chemistry*; D013696:Temperature
D001993:Bronchodilator Agents; D017265:Procaterol