Progeria infantum (Hutchinson-Gilford syndrome) associated with scleroderma-like lesions and acro-osteolysis: a case report and brief review of the literature.
Progeria infantum (Hutchinson-Gilford syndrome) is a very rare syndrome of premature aging characterized by growth retardation and specific, progressive, premature senescent changes of the skin and other tissues. We report a 1.5-year-old girl with loss of scalp hair, eyebrows, and lashes, prominent scalp veins, micrognathia, abnormal ears, loss of subcutaneous tissue, and scleroderma-like areas over the trunk. Radiographic studies revealed coxa valga and acro-osteolysis of the terminal phalanges. The clinical and radiologic features corresponded well with progeria infantum.
Jansen
T
T
Department of Dermatology, Ludwig-Maximilians-University of Munich, Munich, Germany.
Romiti
R
R
D000505:Alopecia / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D010015:Osteolysis, Essential / Q000473:pathology*; D011371:Progeria / Q000473:pathology*; D012594:Scleroderma, Localized / Q000473:pathology*