title: Antimicrobial-drug use and changes in resistance in Streptococcus pneumoniae.
abstract: Resistance of Streptococcus pneumoniae to antimicrobial drugs is increasing. To investigate the relationship between antimicrobial use and susceptibility of S. pneumoniae isolates at 24 U.S. medical centers, we obtained data on outpatient antimicrobial-drug use for the regions surrounding 23 of these centers. We found an association between decreased penicillin susceptibility and use of beta-lactam antimicrobial drugs.
authors.affiliation: University of Iowa College of Medicine, Iowa City, Iowa 52242, USA. daniel-diekema@uiowa.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Diekema
authors.forename: A B
authors.initials: AB
authors.lastname: Brueggemann
authors.forename: G V
authors.initials: GV
authors.lastname: Doern
mesh_terms: D000704:Analysis of Variance; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D014481:United States
chemical_list: D004917:Erythromycin