New substituted 2-(pyrazol-1-yl) o-, m-, p-methylacetanilides with potential local anaesthetic and antiarrhythmic action. Part I.
Fifteen substituted 2-(pyrazol-1-yl)acetanilides were synthesized by N-alkylation of pyrazole and some of its derivatives with several 2-iodoacetanilides. The new compounds exhibited local anaesthetic and antiarrhythmic actions. The new compounds have been characterized by elemental chemical analysis, UV-Vis, IR, 1H, 13C NMR spectra and pharmacology research.
Iovu
M
M
University of Medicine and Pharmaceutics Carol Davila, Department of Organic Chemistry, Bucharest, Romania. iovu@gg.unibuc.ro
Zalaru
C
C
Dumitrascu
F
F
Draghici
C
C
Cristea
E
E
D000083:Acetanilides / Q000737:chemistry / Q000494:pharmacology*; D000779:Anesthetics, Local / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology*; D007928:Lethal Dose 50; D051379:Mice; D013057:Spectrum Analysis
D000083:Acetanilides; D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents