title: Assessing the efficacy of perioperative carprofen administration in dogs undergoing surgical repair of a ruptured cranial cruciate ligament.
abstract: Twenty-one otherwise healthy dogs that presented for surgical repair of a ruptured cranial cruciate ligament were blindly and randomly given either carprofen (2.2 mg/kg body weight, orally) or a placebo beginning 12 hours preoperatively and continuing every 12 hours for a total of three doses. The patients were assessed for postoperative pain using a subjective pain score and given oxymorphone (0.1 mg/kg body weight, intramuscularly) every four hours if the pain score was 2 or greater. Blood samples were also collected to determine serum cortisol levels. There was a significant increase in serum cortisol levels in the immediate postoperative period in both the placebo group and the carprofen group (p less than 0.05). There was no significant difference in the percentage of increase in serum cortisol levels between the two groups. No correlation was evident between the serum cortisol levels and the corresponding pain scores in either group. This subjective method of assessing postoperative pain was not accurate and should not be relied upon for determination of postoperative analgesic administration. Perioperative oral administration of carprofen did not appear to be effective in controlling postoperative pain in these patients.
authors.affiliation: Companion Animal Hospital, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Reese
authors.forename: E J
authors.initials: EJ
authors.lastname: Trotter
authors.forename: C E
authors.initials: CE
authors.lastname: Short
authors.forename: H N
authors.initials: HN
authors.lastname: Erb
authors.forename: L L
authors.initials: LL
authors.lastname: Barlow
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery; D000070598:Anterior Cruciate Ligament Injuries; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D004285:Dogs / Q000293:injuries / Q000502:physiology* / Q000601:surgery; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy / Q000662:veterinary*; D012421:Rupture / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C007005:carprofen; D006854:Hydrocortisone