title: Activity and immobilization after eccentric exercise: II. Serum CK.
abstract: OBJECTIVE
  The purpose of the present study was to examine the effect of muscle activity level on serum creatine kinase (CK) activity after high-force eccentric exercise of the elbow flexors.
  
  
  METHODS
  Twenty-six male volunteers were randomly assigned to one of three groups for a 4-d treatment period after exercise: immobilization (N = 9), control (N = 8), and light exercise (N = 9). During the treatment period, the immobilization group had their arm casted and supported in a sling at 90 degrees. The control group had no restriction of their arm activity. The light exercise group performed a daily exercise regimen of 50 biceps curls with a 5-lb dumbbell. Serum CK activity was obtained by venipuncture for three consecutive days before eccentric exercise and during the 4-d treatment period. To quantify activity of the arm, CSA (Computer Science and Applications, Inc.) activity-monitoring devices were worn.
  
  
  RESULTS
  Serum CK measurements revealed that there was a significant group by time interaction in the analysis of variance (P < 0.05). Peak serum CK activity of the immobilized group (668 IU) was lower than either the control (4230 IU) or light exercise (2740 IU) group. During the treatment period, activity level among the three groups was significantly different from each other (P < 0.001): 529 counts x min(-1) for the immobilization group, 944 counts x min(-1) for the control group, and 1334 counts x min(-1) for the light exercise group.
  
  
  CONCLUSIONS
  These results suggest that immobilization of exercised damaged muscle during recovery significantly blunted serum CK activity, which may be due to attenuated removal of CK from the muscle and/or decrease lymphatic transport.
authors.affiliation: Department of Exercise Science, University of Massachusetts, Amherst 01003, USA. ssayers@excsci.umass.edu
authors.forename: S P
authors.initials: SP
authors.lastname: Sayers
authors.forename: P M
authors.initials: PM
authors.lastname: Clarkson
authors.forename: J
authors.initials: J
authors.lastname: Lee
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000032:analysis* / Q000378:metabolism; D004551:Elbow Joint / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007103:Immobilization; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology / Q000502:physiology; D011897:Random Allocation
chemical_list: D003402:Creatine Kinase