title: Cerebellar cortical abiotrophy in a beagle.
abstract: A beagle puppy was presented with clinical signs indicative of a cerebellar disease. Histopathological evaluation of the cerebellum revealed a diffuse degenerative cortical lesion. The clinical history and the histopathological findings are consistent with a neonatal cerebellar abiotrophy. Furthermore, the breeding history supports the hypothesis of an inherited genetic disorder that is, most likely, an autosomal recessive trait.
authors.affiliation: School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kent
authors.forename: E
authors.initials: E
authors.lastname: Glass
authors.forename: A
authors.initials: A
authors.lastname: deLahunta
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001284:Atrophy / Q000473:pathology / Q000662:veterinary; D002524:Cerebellar Ataxia / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D002531:Cerebellum / Q000473:pathology; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D009474:Neurons / Q000473:pathology