Neurohumoral effects of orphanin FQ/nociceptin: relevance to cardiovascular and renal function.
Orphanin FQ/Nociceptin (OFQ/N) is a peptide whose structure resembles that of the endogenous opioid peptides (endorphins). OFQ/N and its receptor are distributed in neural tissue and brain regions involved in the regulation of pituitary hormone release. Functional studies have shown that this peptide evokes a unique pattern of cardiovascular and renal excretory responses. This review will focus on the neural and humoral effects of OFQ/N and how this peptide may participate in the regulation of cardiovascular and renal function.
Kapusta
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Department of Pharmacology and Experimental Therapeutics, and the Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 1901 Perdido Street, 70112, New Orleans, LA, USA. akapus@lsuhsc.edu
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D004594:Electrophysiology; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000294:innervation; D051379:Mice; D009474:Neurons / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000378:metabolism; D018847:Opioid Peptides / Q000494:pharmacology* / Q000502:physiology*; D010121:Oxytocin / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000187:drug effects; D013997:Time Factors; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology; D000094942:Nociceptin Receptor; D000097629:Nociceptin
D018377:Neurotransmitter Agents; D018847:Opioid Peptides; D010121:Oxytocin; D011957:Receptors, Opioid; D014665:Vasodilator Agents; D014667:Vasopressins; D000094942:Nociceptin Receptor; D000097629:Nociceptin