[Effect of testosterone on carboxypeptidase H activity in the murine hypothalamus and hypophysis].
Effects of single intraperitoneal administration of testosterone propionate (3 or 30 mg/kg body weight) on activity of carboxypeptidase H in pituitary body and hypothalamus of female white mouse were studied. It was found that testosterone propionate treatment (3 and 30 mg/kg body weight) increased the carboxypeptidase H activity in pituitary through 0.5 hour and it decreased one in 24 hours after treatment. The carboxypeptidase H activity in hypothalamus was lower as compared with control animals in 24 hours after testosterone propionate treatment in the dose 3 mg/kg body weight. However, the carboxypeptidase H activity in hypothalamus was lower in 0.5 and 24 hours and it was higher in 4 h after testosterone propionate treatment in the dose 30 mg/kg body weight as compared with the control. These data suggest that testosterone affects the carboxypeptidase H activity by changing the level of enzyme gene expression.
Vernigora
A N
AN
Penza State Pedagogical University.
Gengin
M T
MT
Saldaev
D A
DA
D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007031:Hypothalamus / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D010902:Pituitary Gland / Q000187:drug effects* / Q000201:enzymology; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D002268:Carboxypeptidases; D043423:Carboxypeptidase H