Active conservation of noncoding sequences revealed by three-way species comparisons.
Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.
Dubchak
I
I
Center for Bioinformatics and Computational Genomics, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
Brudno
M
M
Loots
G G
GG
Pachter
L
L
Mayor
C
C
Rubin
E M
EM
Frazer
K A
KA
D000818:Animals; D017124:Conserved Sequence / Q000235:genetics*; D004285:Dogs; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013045:Species Specificity; D020506:Untranslated Regions / Q000235:genetics* / Q000302:isolation & purification
D020506:Untranslated Regions