Sex determination: co-opted signals determine gender.
The Drosophila JAK-STAT pathway and its ligand Unpaired are required for a wide range of developmental processes. Recent results have identified Unpaired as an activator of sex-lethal and revealed a new role for the JAK-STAT pathway in sex determination.
Zeidler
M P
MP
Hughes Medical Institute, Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
Perrimon
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N
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005260:Female; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D007301:Insect Hormones / Q000235:genetics* / Q000378:metabolism; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D050794:STAT1 Transcription Factor; D012730:Sex Chromosomes / Q000235:genetics / Q000378:metabolism; D019849:Sex Determination Processes; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006023:Glycoproteins; D007301:Insect Hormones; D016601:RNA-Binding Proteins; D050794:STAT1 Transcription Factor; C067777:Sxl protein, Drosophila; D015534:Trans-Activators; D014157:Transcription Factors; C115570:upd1 protein, Drosophila; D011505:Protein-Tyrosine Kinases