[The influence of calcium channel blockers on the effects of anxiogenic preparations].
The effect of anxiogenic drugs (caffeine, pentilentetrazole, phenilethylamine, strophantine, BAY K 8644) on SHR mice' behavior was studied in the dark-light chamber test. All these drugs have diminished the number of transitions between the chambers. Pretreatment with verapamil, nifedipine, cinnarizine and fendilin have not altered the effect of relevant anxiogenic drugs. Diltiazem prevented the effect of stophantine. It is suggested that the lack of the effect of calcium channel blockers on the action of anxiogens is related to peculiarities of formation of anxiety in this test.
Kozlovskiĭ
V L
VL
D000818:Animals; D021461:Animals, Outbred Strains; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001007:Anxiety / Q000139:chemically induced* / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D003624:Darkness; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D008027:Light; D008297:Male; D051379:Mice; D013997:Time Factors
D014151:Anti-Anxiety Agents; D002121:Calcium Channel Blockers