title: Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis griff. ex T. anders.
abstract: Crude extracts (methanol) of various parts, viz. the leaves, fruits, roots, stem and trunk bark, of Garcinia atroviridis were screened for antimicrobial, cytotoxic, brine shrimp toxic, antitumour-promoting and antioxidant activities. The crude extracts exhibited predominantly antibacterial activity with the root extract showing the strongest inhibition against the test bacteria at a minimum inhibitory dose (MID) of 15.6 microg/disc. Although all the extracts failed to inhibit the growth of most of the test fungi, significant antifungal activity against Cladosporium herbarum was exhibited by most notably the fruit (MID: 100 microg), and the leaf (MID: 400 microg) extracts. None of the extracts were significantly cytotoxic, and lethal towards brine shrimps. The root, leaf, trunk and stem bark extracts (except for the fruits) showed strong antioxidant activity exceeding that of the standard antioxidant, alpha-tocopherol. Antitumour-promoting activity (>95% inhibition) was shown by the fruit, leaf, stem and trunk bark extracts.
authors.affiliation: Department of Biotechnology, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
authors.forename: M M
authors.initials: MM
authors.lastname: Mackeen
authors.forename: A M
authors.initials: AM
authors.lastname: Ali
authors.forename: N H
authors.initials: NH
authors.lastname: Lajis
authors.forename: K
authors.initials: K
authors.lastname: Kawazu
authors.forename: Z
authors.initials: Z
authors.lastname: Hassan
authors.forename: M
authors.initials: M
authors.lastname: Amran
authors.forename: M
authors.initials: M
authors.lastname: Habsah
authors.forename: L Y
authors.initials: LY
authors.lastname: Mooi
authors.forename: S M
authors.initials: SM
authors.lastname: Mohamed
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002460:Cell Line; D033364:Decapoda; D006801:Humans; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*; D019685:Rosales / Q000737:chemistry*; D018675:Toxicity Tests
chemical_list: D000900:Anti-Bacterial Agents; D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts