title: Intraepithelial carcinoma of the oesophagus: report of 25 cases from north-east Italy.
abstract: OBJECTIVE
  To investigate the incidence and define the diagnostic aspects of intraepithelial squamous cell carcinoma of the oesophagus and to show the trend in its natural history.
  
  
  METHODS
  Analysis of records of more than 31000 upper gastrointestinal endoscopies in a secondary referral centre.
  
  
  METHODS
  Gastroenterology unit, Italy.
  
  
  METHODS
  23 men and 2 women with endoscopic and histological diagnoses of intraepithelial squamous cell carcinoma of the oesophagus.
  
  
  RESULTS
  The incidence was 0.8/1000 patients/year. There was a coexisting oropharyngeal or laryngeal cancer in 17 patients. The endoscopic appearance was of a more or less well-defined hyperaemic area. Lesions progressed to infiltrating carcinoma in a mean of 18.3 months range 11-32).
  
  
  CONCLUSIONS
  Intraepithelial squamous cell carcinoma is rare in this population. Endoscopy and histology are essential for diagnosis and staging.
authors.affiliation: Gastroenterology Unit, Santa Maria degli Angeli Hospital, Pordenone, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Benedetti
authors.forename: R
authors.initials: R
authors.lastname: Sablich
authors.forename: A
authors.initials: A
authors.lastname: Vitalba
authors.forename: T
authors.initials: T
authors.lastname: Lacchin
authors.forename: E
authors.initials: E
authors.lastname: Guido
authors.forename: T
authors.initials: T
authors.lastname: Del Bianco
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging