title: Stability constants of potent cytotoxic copper(II) complexes with furan semicarbazones in ethanolic solutions.
abstract: Potent cytotoxic copper(II) complexes of furannic semicarbazones were studied in ethanolic solutions at 25 degrees C. The four ligands used were synthesized in our laboratory, i.e. 2-furfural semicarbazone (FSC), 5-methyl 2-furfural semicarbazone (MFSC), 2-furfural 4-phenyl semicarbazone (FPSC) and 3-(2-furyl) prop-2-enal semicarbazone (FASC). The mathematical analysis was carried out with a recent computer program SIRKO which indicated the formation of one metal-ligand complex in each case and the logarithm of their stability constants are: log beta=2.02, 3.84, 4.58 and 4.52 for ligands FSC, MFSC, FASC and FPSC, respectively. A relation between stability and molecular weight of the ligands is proposed which may prove to be interesting as these complexes are being investigated for their cytotoxic activities.
authors.affiliation: Université Libanaise, Ramlé El-Baïda, Beyrouth, Lebanon.
authors.forename: G
authors.initials: G
authors.lastname: Ibrahim
authors.forename: G M
authors.initials: GM
authors.lastname: Bouet
authors.forename: I H
authors.initials: IH
authors.lastname: Hall
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
mesh_terms: D003300:Copper; D003603:Cytotoxins / Q000737:chemistry*; D004355:Drug Stability; D000431:Ethanol; D009942:Organometallic Compounds / Q000737:chemistry*; D012664:Semicarbazones; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
chemical_list: D003603:Cytotoxins; D009942:Organometallic Compounds; D012664:Semicarbazones; D012996:Solutions; D000431:Ethanol; D003300:Copper