title: Different myelination of rat septohippocampal fibres as revealed by immunofluorescence double-labelling.
abstract: The present study focuses on the myelination of rat septohippocampal fibres that are known to originate from GABAergic parvalbumin-containing, fast-firing, fast-conducting neurons and from cholinergic slow-firing, slow-conducting neurons. With the combined immunofluorescence for parvalbumin/myelin basic protein and choline acetyltransferase/myelin basic protein it was shown that the vast majority of parvalbumin-containing fibres are myelinated, but the choline acetyltransferase-containing fibres are not. Accordingly, our results confirm the expectation that conduction velocities and presence or absence of myelin sheaths are also correlated in the septohippocampal pathway.
authors.affiliation: Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D-04109 Leipzig, Germany. aret@server3.medizin.uni-leipzig.de
authors.forename: K
authors.initials: K
authors.lastname: Brauer
authors.forename: W
authors.initials: W
authors.lastname: Härtig
authors.forename: U
authors.initials: U
authors.lastname: Gärtner
authors.forename: G
authors.initials: G
authors.lastname: Brückner
authors.forename: T
authors.initials: T
authors.lastname: Arendt
mesh_terms: D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D004676:Myelin Basic Protein / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology*; D009412:Nerve Fibers / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism; D009431:Neural Conduction; D010320:Parvalbumins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012688:Septum Pellucidum / Q000502:physiology*; D013997:Time Factors
chemical_list: D004676:Myelin Basic Protein; D010320:Parvalbumins; D002795:Choline O-Acetyltransferase