[Correcting influence of vitamin E short chain derivatives on lipid peroxidation, liver cell membrane, and chromatin structure when rats are exposed to embichin].
Embikhin causes activation of LPO processes in endoplasmic reticulum and in nuclear chromatine fractions of rat liver cells. The latter is accompanied by the impairment of repressive and active nuclear chromatine fractions structure. Derivate of vitamin E in these conditions renders correcting action on parameters of lipid peroxidation in the investigated subcellular structures, testifying its positive influence on the cell heredity apparatus state. The normalizing action of tocopherol derivative on cytochromes P450 and b5 levels is shown.
Kovalenko
V M
VM
Institute of Pharmacology and Toxicology, AMS of Ukraine, Kyiv.
Byshovets'
T F
TF
Hubs'kyĭ
Iu I
IuI
Levyts'kyĭ
Ie L
IeL
Shaiakhmetova
H M
HM
Marchenko
O M
OM
Voloshyna
O S
OS
Saĭfetdinova
H A
HA
Okhrimenko
V O
VO
Donchenko
H V
HV
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D002843:Chromatin / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008466:Mechlorethamine / Q000494:pharmacology*; D011487:Protein Conformation; D051381:Rats; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology
D002843:Chromatin; D014810:Vitamin E; D008466:Mechlorethamine