Different myelination of rat septohippocampal fibres as revealed by immunofluorescence double-labelling.
The present study focuses on the myelination of rat septohippocampal fibres that are known to originate from GABAergic parvalbumin-containing, fast-firing, fast-conducting neurons and from cholinergic slow-firing, slow-conducting neurons. With the combined immunofluorescence for parvalbumin/myelin basic protein and choline acetyltransferase/myelin basic protein it was shown that the vast majority of parvalbumin-containing fibres are myelinated, but the choline acetyltransferase-containing fibres are not. Accordingly, our results confirm the expectation that conduction velocities and presence or absence of myelin sheaths are also correlated in the septohippocampal pathway.
Brauer
K
K
Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D-04109 Leipzig, Germany. aret@server3.medizin.uni-leipzig.de
Härtig
W
W
Gärtner
U
U
Brückner
G
G
Arendt
T
T
D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D004676:Myelin Basic Protein / Q000378:metabolism; D009186:Myelin Sheath / Q000502:physiology*; D009412:Nerve Fibers / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism; D009431:Neural Conduction; D010320:Parvalbumins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012688:Septum Pellucidum / Q000502:physiology*; D013997:Time Factors
D004676:Myelin Basic Protein; D010320:Parvalbumins; D002795:Choline O-Acetyltransferase