Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex.
The integral membrane protein complex quinol-fumarate reductase catalyzes the terminal step of a major anaerobic respiratory pathway. The homologous enzyme succinate-quinone oxidoreductase participates in aerobic respiration both as complex II and as a member of the Krebs cycle. Last year, two structures of quinol-fumarate reductases were reported. These structures revealed the cofactor organization linking the fumarate and quinol sites, and showed a cofactor arrangement across the membrane that is suggestive of a possible energy coupling function.
Iverson
T M
TM
Graduate Option in Biochemistry, California Institute of Technology, Pasadena 91125, USA.
Luna-Chavez
C
C
Schröder
I
I
Cecchini
G
G
Rees
D C
DC
D000818:Animals; D004579:Electron Transport; D042963:Electron Transport Complex II; D004734:Energy Metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D010088:Oxidoreductases / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D011809:Quinones / Q000737:chemistry* / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000737:chemistry* / Q000378:metabolism
D009097:Multienzyme Complexes; D011809:Quinones; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase