title: Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group.
abstract: A prospective population-based study was conducted in Australia and New Zealand during 1994-1997 to elucidate the epidemiology of cryptococcosis due to Cryptococcus neoformans var. neoformans (CNVN) and C. neoformans var. gattii (CNVG) and to relate clinical manifestations to host immune status and cryptococcal variety. The mean annual incidence per 10(6) population was 6.6 in Australia and 2.2 in New Zealand. Of 312 episodes, CNVN caused 265 (85%; 98% of the episodes in immunocompromised hosts) and CNVG caused 47 (15%; 44% of the episodes in immunocompetent hosts). The incidence of AIDS-associated cases in Australia declined annually (P<.001). Aborigines in rural or semirural locations (P<.001) and immunocompetent males (P<.001) were at increased risk of CNVG infection. Cryptococcomas in lung or brain were more common in immunocompetent hosts (P< or =.03) in whom there was an association only between lung cryptococcomas and CNVG. An AIDS-associated genetic profile of CNVN serotype A was confirmed by random amplification of polymorphic DNA analysis. Resistance to antifungal drugs was uncommon. The epidemiology of CNVN infection has changed substantially. Clinical manifestations of disease are influenced more strongly by host immune status than by cryptococcal variety.
authors.affiliation: Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia. sharonc@icpmr.wsahs.nsw.gov.au
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Sorrell
authors.forename: G
authors.initials: G
authors.lastname: Nimmo
authors.forename: B
authors.initials: B
authors.lastname: Speed
authors.forename: B
authors.initials: B
authors.lastname: Currie
authors.forename: D
authors.initials: D
authors.lastname: Ellis
authors.forename: D
authors.initials: D
authors.lastname: Marriott
authors.forename: T
authors.initials: T
authors.lastname: Pfeiffer
authors.forename: D
authors.initials: D
authors.lastname: Parr
authors.forename: K
authors.initials: K
authors.lastname: Byth
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000494:pharmacology; D001315:Australia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003453:Cryptococcosis / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D003455:Cryptococcus neoformans / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009520:New Zealand / Q000453:epidemiology; D011446:Prospective Studies; D019105:Random Amplified Polymorphic DNA Technique
chemical_list: D000935:Antifungal Agents