Peculiarities of cardiotropic effect of aconitine.
In experiments on anesthetized cats, aconitine produced direct arrhythmogenic and cardiotoxic effects on the myocardium combined with indirect cardiotropic effects mediated via activation of extracardial nerves. Aconitine demonstrated pronounced cholinolytic properties and blocked vagal arrhythmogenic effect.
Sheikh-Zade
Y R
YR
Department of Normal Physiology, Kuban Medical Academy, Krasnodar.
Cherednik
I L
IL
Galenko-Yaroshevskii
P A
PA
D000157:Aconitine / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D006321:Heart / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology
D000276:Adjuvants, Immunologic; D000157:Aconitine