DNA triple helix stabilization by aminoglycoside antibiotics.
The stabilization of the poly(dA) x 2poly(dT) triple helix by neomycin is reported. Preliminary results indicate that neomycin stabilizes DNA triple helices and the double helical structures composed of poly(dA) x poly(dT) are virtually unaffected. This is the first report of the interaction of aminoglycoside antibiotics with DNA triple helices.
Arya
D P
DP
Department of Chemistry, Clemson University, SC 29634, USA. dparya@clemson.edu
Coffee
R L
RL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D009355:Neomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004247:DNA; D009355:Neomycin