Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors.
Ishida
J
J
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA.
Kozuka
M
M
Wang
H
H
Konoshima
T
T
Tokuda
H
H
Okuda
M
M
Yang Mou
X
X
Nishino
H
H
Sakurai
N
N
Lee
K H
KH
Nagai
M
M
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity; D036381:Diarylheptanoids; D004305:Dose-Response Relationship, Drug; D005260:Female; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D006801:Humans; D006844:Hydrocarbons, Cyclic / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013047:Specific Pathogen-Free Organisms; D013729:Terpenes / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013997:Time Factors; D014407:Tumor Cells, Cultured; D014775:Virus Activation / Q000187:drug effects
D000970:Antineoplastic Agents; D002273:Carcinogens; D036381:Diarylheptanoids; D006844:Hydrocarbons, Cyclic; D013729:Terpenes; C041795:myricanone; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate