title: Randomised, placebo-controlled study of the postoperative analgesic effects of ketoprofen after spinal fusion surgery.
abstract: BACKGROUND
  The additive effect of non-steroidal anti-inflammatory drugs administered with propacetamol after major orthopaedic surgery has not been studied. Thus, we performed a prospective, placebo-controlled study to assess the analgesic effects of ketoprofen in patients undergoing spinal fusion surgery and receiving propacetamol.
  
  
  METHODS
  Fifty patients undergoing spinal fusion surgery received either 100 mg of ketoprofen every 8 h or a placebo, postoperatively. All patients received propacetamol and morphine (intravenous titration followed by patient-controlled analgesia (PCA) over 24 h). Pain was assessed using a visual analogue pain scale (VASpi). Data are mean+/-SD.
  
  
  RESULTS
  During morphine titration, ketoprofen did not significantly reduce the dose of morphine (8+/-6 vs 11+/-4 mg, NS) whereas it significantly decreased VASpi (P<0.001). During PCA, ketoprofen significantly reduced morphine consumption (25+/-17 vs 38+/-20 mg, P=0.04) and VASpi (P=0.002). The total postoperative morphine consumption was significantly (33%) reduced with ketoprofen.
  
  
  CONCLUSIONS
  Ketoprofen reduced morphine requirements and improved postoperative analgesia in patients undergoing major spinal surgery and receiving propacetamol.
authors.affiliation: Department of Anaesthesiology and Critical Care, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France. frederic.aubrun@psl.ap-hop-paris.fr
authors.forename: F
authors.initials: F
authors.lastname: Aubrun
authors.forename: O
authors.initials: O
authors.lastname: Langeron
authors.forename: D
authors.initials: D
authors.lastname: Heitz
authors.forename: P
authors.initials: P
authors.lastname: Coriat
authors.forename: B
authors.initials: B
authors.lastname: Riou
mesh_terms: D000082:Acetaminophen / Q000031:analogs & derivatives / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D013123:Spinal Fusion
chemical_list: D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000082:Acetaminophen; C063776:propacetamol; D009020:Morphine; D007660:Ketoprofen