[Comparison of platelet activation and procoagulant activity of blood cells in healthy pregnant women and EPH-gestosis patients].
OBJECTIVE
EPH-gestosis is one of the most frequent complications of pregnancy, labour and puerperium. Despite its unknown ethiology, many authors suggest a vital role played by platelets as an ethiopathogenic factor. The aim of this study was to observe the level of platelets activation in EPH-gestosis subjects.


METHODS
Platelets activation level has been observed in 16 EPH-gestosis third semester pregnant women and 14 normotensive third semester pregnant controls. Platelets double-labeled with monoclonal antibodies and a flow cytometer have been used in assessment of platelet activation level. Anti-P-selectin (GMP 140- Granule Membrane Protein) has been used as a marker of the platelet released reaction. Fibrinogen, D-dimers, antithrombin and thrombin-antithrombin complexes levels have been analyzed.


RESULTS
An increased platelet activation (p < 0.005) as well as the increased level of thrombin-antithrombin (p < 0.005) in pregnant EPH-gestosis women comparing to control group, has been observed in the study.


CONCLUSIONS
A state of hypercoaguability and enhanced platelet activation in pregnant EPH-gestosis women have been observed.
Kolasa
D
D
Kliniki Chirurgii Ginekologicznej, Instytut-Centrum Zdrowia Matki Polki, Lódź.
Malinowski
A
A
Baj
Z
Z
Owczarek
D
D
Szpakowski
A
A
Dyński
M A
MA
Szpakowski
M
M
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology; D005260:Female; D005340:Fibrinogen / Q000502:physiology*; D006801:Humans; D015539:Platelet Activation / Q000502:physiology*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013917:Thrombin / Q000502:physiology*
D000911:Antibodies, Monoclonal; D005340:Fibrinogen; D013917:Thrombin