title: [Intraoperative brachytherapy in the management of keloids. Apropos of 114 cases]  .
abstract: OBJECTIVE
  Keloid scars are unsightly, especially when located on the face or bare zones. The purpose of this study was to evaluate the therapeutic results of intraoperative brachytherapy in the management of keloids.
  
  
  METHODS
  This retrospective study was based on the study of 82 patients with keloids treated in Salah Azaiz Institute (Tunisia) between 1982 and 1994 (65 women and 17 men). The mean age of patients was 23.4 years (+/- 8.4). A total of 114 lesions have been treated with surgical resection and intraoperative brachytherapy using an iridium source placed under the surgical scar. The length of iridium was chosen with the result that the radioactive thread exceeded 5 mm on each side of the surgical scar. The iridium source was loaded less than six hours after resection. Average iridium activity was 1.5 +/- 0.3 mCi/cm. Average iridium length was 56.8 +/- 34 mm. The referred isodose chosen for the target volume included the surgical scar and a margin of 5 mm around the iridium source, which was placed under the surgical scar. The average administered dose was 20.4 Gy (+/- 3.2 Gy).
  
  
  RESULTS
  The 2-year local control rate was 87% for the whole group of lesions treated (n = 114). Local control rate of keloids processed by resection and intraoperative brachytherapy as the first treatment (59 cases) was 96% at two years. This rate was better than the local control of lesions that had been previously treated with anterior surgical resection (84% in 55 cases). For the latter group, lesions treated with a dose of more than 20 Gy had better local control, but the difference was not statistically significant (87 vs. 65% at two years, P = 0.41).
  
  
  CONCLUSIONS
  Intraoperative brachytherapy is effective for improving local control of keloids and preventing a recurrence. A rigorous technique and an adequate dose according to previous surgical treatment allows very good results.
authors.affiliation: Service de radiothérapie, institut Salah-Azaiz, Tunis, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Maalej
authors.forename: H
authors.initials: H
authors.lastname: Frikha
authors.forename: N
authors.initials: N
authors.lastname: Bouaouina
authors.forename: J
authors.initials: J
authors.lastname: Daoud
authors.forename: M
authors.initials: M
authors.lastname: Besbes
authors.forename: F
authors.initials: F
authors.lastname: Benna
authors.forename: D
authors.initials: D
authors.lastname: Sellami
authors.forename: N
authors.initials: N
authors.lastname: Bennour
authors.forename: M
authors.initials: M
authors.lastname: Jellouli
authors.forename: S
authors.initials: S
authors.lastname: Gritli
authors.forename: M
authors.initials: M
authors.lastname: Guigua
authors.forename: M
authors.initials: M
authors.lastname: Ben Abdallah
mesh_terms: D000328:Adult; D001918:Brachytherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D007627:Keloid / Q000532:radiotherapy* / Q000601:surgery*; D008297:Male; D011879:Radiotherapy Dosage; D012189:Retrospective Studies