p73: structure and function.
Alteration of the p53 tumor suppressor gene is a common, if not general, observation in human malignant tumors. p73 Is a novel member of the p53 family at chromosome 1p36.3, at which locus frequent defects are seen in many tumors including neuroblastoma. Besides structural similarities, the fact that p73 functions in the regulation of the cell cycle and apoptosis promotes the expansion of the research field concerning p53-associated tumor progression. In this paper, we review the structure and function of p73 as well as the mutational status in various human tumors. In addition, possibilities for new therapeutic applications with p73 for cancer cell control are discussed.
Ichimiya
S
S
Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan. ichimiya@sapmed.ac.jp
Nakagawara
A
A
Sakuma
Y
Y
Kimura
S
S
Ikeda
T
T
Satoh
M
M
Takahashi
N
N
Sato
N
N
Mori
M
M
D017209:Apoptosis / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000502:physiology*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D009687:Nuclear Proteins / Q000502:physiology*; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins