title: Diversity and prevalence of PorA types in Neisseria meningitidis serogroup B in the United States, 1992-1998.
abstract: Two hundred eighty-one sporadic Neisseria meningitidis serogroup B isolates, collected through active laboratory-based surveillance, were selected to be analyzed by PorA variable region (VR) typing to determine the prevalence of PorA types in the United States. A substantial number of distinct VR types were identified, 31 in VR1 and 41 in VR2. A total of 73 different PorA types were found, and 76. 7% of these types comprise nonprototype sequences in VR1, VR2, or both. The most prevalent PorA types were P1.7,16-20 (previously P1.7, 16i), P1.22,14, P1.22-1,14 (previously P1.22a,14), P1.7,16, P1.7-1,1 (previously P1.7d,1), P1.19,15, and P1.17,16-3 (previously P1.B,16d). No correlation was observed between the PorA types and geographic origin of the isolates. These data may aid in the design of an efficacious outer membrane protein-based vaccine by identifying the most appropriate PorA types for vaccine formulation. Studies are needed to fully evaluate the extent of cross-protection in humans among the variants and prototypes in each PorA VR family.
authors.affiliation: Meningitis and Special Pathogens Branch, Mail Stop D-11, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. cls9@cdc.gov
authors.forename: C T
authors.initials: CT
authors.lastname: Sacchi
authors.forename: A M
authors.initials: AM
authors.lastname: Whitney
authors.forename: T
authors.initials: T
authors.lastname: Popovic
authors.forename: D S
authors.initials: DS
authors.lastname: Beall
authors.forename: M W
authors.initials: MW
authors.lastname: Reeves
authors.forename: B D
authors.initials: BD
authors.lastname: Plikaytis
authors.forename: N E
authors.initials: NE
authors.lastname: Rosenstein
authors.forename: B A
authors.initials: BA
authors.lastname: Perkins
authors.forename: M L
authors.initials: ML
authors.lastname: Tondella
authors.forename: L W
authors.initials: LW
authors.lastname: Mayer
mesh_terms: D002487:Centers for Disease Control and Prevention, U.S.; D014644:Genetic Variation; D006801:Humans; D008585:Meningitis, Meningococcal / Q000453:epidemiology / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D011159:Population Surveillance; D018272:Porins / Q000235:genetics*; D014481:United States / Q000453:epidemiology
chemical_list: D018272:Porins