title: Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors.
abstract: Compound affinity for activated and resting GPIIb/IIIa receptors may differ, and comparison of those differences determines selectivity. Structural features that influence selectivity are discussed.
authors.affiliation: Merck Research Laboratories, Department of Medicinal Chemistry, West Point, PA 19486, USA. melissa_egbertson@merck.com
authors.forename: M S
authors.initials: MS
authors.lastname: Egbertson
authors.forename: B
authors.initials: B
authors.lastname: Bednar
authors.forename: B C
authors.initials: BC
authors.lastname: Askew
authors.forename: R A
authors.initials: RA
authors.lastname: Bednar
authors.forename: K
authors.initials: K
authors.lastname: Brashear
authors.forename: M J
authors.initials: MJ
authors.lastname: Breslin
authors.forename: M E
authors.initials: ME
authors.lastname: Duggan
authors.forename: T E
authors.initials: TE
authors.lastname: Fisher
authors.forename: W
authors.initials: W
authors.lastname: Halczenko
authors.forename: J H
authors.initials: JH
authors.lastname: Hutchinson
authors.forename: N
authors.initials: N
authors.lastname: Ihle
authors.forename: J D
authors.initials: JD
authors.lastname: Prugh
authors.forename: J S
authors.initials: JS
authors.lastname: Wai
authors.forename: R J
authors.initials: RJ
authors.lastname: Gould
authors.forename: G D
authors.initials: GD
authors.lastname: Hartman
mesh_terms: D000577:Amides / Q000737:chemistry; D006801:Humans; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D019039:Platelet Glycoprotein GPIIb-IIIa Complex