[Evaluation of modern antibiotics efficacy at experimental Northern Asia rickettsiosis].
Comparative investigation of antibiotics therapy efficacy at experimental murine Northern Asia rickettsiosis was performed. The efficacy was evaluated by the determination of protective activity in per cent and by the pathogen erradication. The investigated antibiotics may be ranged in the following order (by the diminishing efficacy): ansamycins (azorif, rifapentine, rifampicin), tetracyclines (doxycycline), macrolides (azitromycin, sumamed), carbapenems (imipenem/cilastatin), fluoroquinolones (lomefloxacin, pefloxacin). Rifampicin and its derivatives--azorif, rifapentine, along with doxycycline and azitromycm can be recommended for clinical trials at experimental rickettsiosis profilaxy and treatment in natural infection focus.
D'iakov
S I
SI
Research Institute of Military Medicine, St. Peterburg.
Misnikova
M A
MA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008809:Mice, Inbred C3H; D012281:Rickettsia / Q000187:drug effects; D012282:Rickettsia Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents