One-step construction of the pentacyclic skeleton of saframycin A from a "Trimer" of alpha-amino aldehydes.
The entire skeleton of the saframycin antitumor antibiotics is assembled in one remarkable transformation (8 --> 9) from an N-linked oligomer of three alpha-amino aldehyde components, a reaction pathway that may parallel the biosynthetic route to the saframycins.
Myers
A G
AG
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. myers@chemistry.harvard.edu
Kung
D W
DW
D000447:Aldehydes / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*
D000447:Aldehydes; D000903:Antibiotics, Antineoplastic; D007546:Isoquinolines; C026925:saframycin A