title: Translocases: a bacterial tunnel for drugs and proteins.
abstract: Unrelated translocases extrude proteins or antimicrobial agents across both membranes of the cell envelope in Gram-negative bacteria. The TolC protein links the translocases to the external environment. The recently determined crystal structure of TolC shows how this universal tunnel operates.
authors.affiliation: Biotechnology Center, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA. klewis@tufts.edu
authors.forename: K
authors.initials: K
authors.lastname: Lewis
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; D008074:Lipoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D026901:Membrane Transport Proteins; D008958:Models, Molecular; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D011487:Protein Conformation; D021381:Protein Transport
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C083497:AcrA protein, E coli; C083496:AcrB protein, E coli; C489681:EmrA protein, E coli; C065231:HlyD protein, E coli; C050837:Hlyb protein, Bacteria; C073126:tolC protein, E coli; C077168:emrA protein, Bacteria; C077169:VceB protein, Vibrio cholerae