Pelorol from the tropical marine sponge Dactylospongia elegans.
From the dichloromethane solubles of the tropical marine sponge Dactylospongia elegans, a new aromatic substituted sesquiterpene, pelorol (1), and the known sesquiterpene, ilimaquinone (2), were isolated. The structures of 1 and 2 were deduced from their spectroscopic data. The biological activities of compounds 1 and 2 were assessed in a variety of bioassays, and both compounds were found to have weak antitrypanosomal and antiplasmodial effects.
Goclik
E
E
Institute for Pharmaceutical Biology, Technical University Braunschweig, Mendelssohnstrasse 1, D-38106 Braunschweig, Germany.
König
G M
GM
Wright
A D
AD
Kaminsky
R
R
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001681:Biological Assay; D002850:Chromatography, Gel; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D011161:Porifera / Q000737:chemistry*; D011793:Queensland; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000981:Antiprotozoal Agents; D004791:Enzyme Inhibitors; D011809:Quinones; D012717:Sesquiterpenes; C414692:pelorol; C067346:illimaquinone