title: Frequent expression of sialyl Le(a) in human esophageal squamous cell carcinoma.
abstract: Sialyl Le(a) antigen (CA19-9), a member of a family of high molecular weight glycoproteins, was originally described as a gastrointestinal- and pancreatic-specific tumor marker. Recent studies have demonstrated that sialyl Le(a) is a ligand for E-selectin and may play an important role in tumor metastasis. However, expression patterns of sialyl Le(a) have not yet been established in human esophageal carcinomas. In this study, we examined sialyl Le(a) expression and its histopathological localization in human esophageal squamous cell carcinoma. Sialyl Le(a) immunoreactivity was detected in 28 (51.9%) of the 54 esophageal squamous cell carcinomas, regardless of the depth of tumor invasion, vascular invasion or lymph nodal status. In 13 cases (29.5%), significant sialyl Le(a) expression was detected not only in the intramucosal carcinoma components, but also in the invasive carcinoma components. These observation suggested that sialyl Le(a) expression is associated with early-stage cancer progression.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa 259-1193, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Oshiba
authors.forename: H
authors.initials: H
authors.lastname: Kijima
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Kenmochi
authors.forename: S
authors.initials: S
authors.lastname: Himeno
authors.forename: Y
authors.initials: Y
authors.lastname: Kise
authors.forename: T
authors.initials: T
authors.lastname: Nishi
authors.forename: O
authors.initials: O
authors.lastname: Chino
authors.forename: H
authors.initials: H
authors.lastname: Shimada
authors.forename: Y
authors.initials: Y
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Yamazaki
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Ueyama
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D018395:CA-19-9 Antigen; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000378:metabolism / Q000473:pathology*; D005732:Gangliosides / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry
chemical_list: D018395:CA-19-9 Antigen; D005732:Gangliosides; C064564:sialyl Le(a) ganglioside