title: Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase.
abstract: We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration.
authors.affiliation: Department of Neurology, Kentucky Clinic, Room L-445, University of Kentucky, Lexington, KY 40536-0284, USA. maragos@pop.uky.edu
authors.forename: W F
authors.initials: WF
authors.lastname: Maragos
authors.forename: R
authors.initials: R
authors.lastname: Jakel
authors.forename: D
authors.initials: D
authors.lastname: Chesnut
authors.forename: C B
authors.initials: CB
authors.lastname: Pocernich
authors.forename: D A
authors.initials: DA
authors.lastname: Butterfield
authors.forename: D
authors.initials: D
authors.lastname: St Clair
authors.forename: W A
authors.initials: WA
authors.lastname: Cass
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D008694:Methamphetamine / Q000037:antagonists & inhibitors* / Q000506:poisoning*; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics; D008928:Mitochondria / Q000201:enzymology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D012016:Reference Values; D013482:Superoxide Dismutase / Q000235:genetics / Q000494:pharmacology*
chemical_list: D009419:Nerve Tissue Proteins; D008694:Methamphetamine; D013482:Superoxide Dismutase; D004298:Dopamine