Tumor suppressors: linking cell polarity and growth control.
The Drosophila tumor suppressor genes scribble, discs large and lethal giant larvae appear to act in a common pathway. Mutations in any of these genes lead to loss of apical-basal cell polarity and overproliferation of epithelia, revealing a close connection between cytoarchitecture and growth control.
Wodarz
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Institut für Genetik, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. wodarz@uni-duesseldorf.de
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics; D016764:Cell Polarity / Q000235:genetics*; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans