title: Transforming growth factor-beta: pleiotropic role in the regulation of hematopoiesis.
abstract: Hematopoiesis is a remarkable cell-renewal process that leads to the continuous generation of large numbers of multiple mature cell types, starting from a relatively small stem cell compartment. A highly complex but efficient regulatory network is necessary to tightly control this production and to maintain the hematopoietic tissue in homeostasis. During the last 3 decades, constantly growing numbers of molecules involved in this regulation have been identified. They include soluble cytokines and growth factors, cell-cell interaction molecules, and extracellular matrix components, which provide a multifunctional scaffolding specific for each tissue. The cloning of numerous growth factors and their mass production have led to their possible use for both fundamental research and clinical application.
authors.affiliation: Laboratoire de Biologie des Cellules Souches Somatiques Humaines, Centre National de la Recherche Scientifique, Villejuif, France.
authors.forename: N O
authors.initials: NO
authors.lastname: Fortunel
authors.forename: A
authors.initials: A
authors.lastname: Hatzfeld
authors.forename: J A
authors.initials: JA
authors.lastname: Hatzfeld
mesh_terms: D000818:Animals; D006410:Hematopoiesis; D006801:Humans; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology*
chemical_list: D016212:Transforming Growth Factor beta