title: [Effect of ammonia on the pig respiratory system. Study of the dose-response relation].
abstract: The effects of ammonia on the respiratory system and somatic growth have been measured in piglets taking into account the interactions with endotoxins from gram-bacteria and dust. Dose-response curves were constructed for the inflammatory reactions induced in nasal cavities, the smooth muscle hyperresponsiveness in the trachea, the permeability of alveolo-capillary barrier, the pulmonary vasomotricity, the cough reflex and the systemic effects. An acceptable level of pollution was proposed.
authors.affiliation: Service de Pharmacologie-Pharmacothérapie-Toxicologie, Faculté de médecine vétérinaire de l'Université de Liège.
authors.forename: P
authors.initials: P
authors.lastname: Gustin
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000641:Ammonia / Q000009:adverse effects*; D000818:Animals; D016535:Bronchial Hyperreactivity / Q000139:chemically induced* / Q000503:physiopathology; D002199:Capillary Permeability / Q000187:drug effects; D003371:Cough / Q000139:chemically induced; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006130:Growth Disorders / Q000139:chemically induced*; D007249:Inflammation; D011652:Pulmonary Circulation / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects*; D013552:Swine
chemical_list: D000393:Air Pollutants; D000641:Ammonia