[Growth hormone and its interactions with chosen parameters of hormonal state in pre-menopausal women after mastectomy for breast cancer on adjuvant chemotherapy].
It seems, that quantitative changes of growth hormone (GH) in blood and imbalance between GH and hormones can influence the breast cancer cells proliferation, and can be a favourable element in breast cancer progression. The procedure to normalize hormonal system can have a therapeutic action. The aim of the presented work is to asses the plasma GH levels in 24 pre-menopausal women after mastectomy for breast cancer on adjuvant chemotherapy with cyclophosphamide, methotrexate, 5-fluorouracil (CMF). In this study interactions between GH and insulin like growth factor-I, prolactin, estradiol, progesterone (P), melatonin, cortisol and met-enkephalin were assessed. The control group was consisted of 16 healthy women. Plasma GH concentration and interactions between GH and studied parameters in women with breast cancer did not differ from healthy women. Highly significant positive correlation between GH and P after administration CMF was shown. CMF did not influence the interactions between GH and other studied parameters.
Kajdaniuk
D
D
I Katedry i Zakładu Patofizjologii Slaskiej Akademii Medycznej w Katowicach.
Marek
B
B
Kos-Kudła
B
B
Buntner
B
B
Zwirska-Korczala
K
K
Ostrowska
Z
Z
Nowak
M
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006728:Hormones / Q000378:metabolism*; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D011184:Postoperative Period; D017697:Premenopause / Q000502:physiology*; D013002:Somatomedins / Q000378:metabolism*
D006728:Hormones; D013002:Somatomedins; D019382:Human Growth Hormone