Study of the relationship between chemical structure and antimicrobial activity in a series of hydrazine-based coordination compounds.
The dependence of antimicrobial activity on the structure of compounds is studied in a series of compounds based on hydrazine coordinated with ions of Cu(II), Ni(II) and Pd(II). The study has been carried out by means of the original electron-topological method developed earlier. A molecular fragment has been found that is only characteristic of biologically active compounds. Its spatial and electron parameters have been used for the quantitative assessment of the activity in view. The results obtained can be used for the antimicrobial activity prediction in a series of compounds with similar structures.
Dobrova
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BN
Institute of Chemistry, Academy of Sciences, Kishinev, Moldova.
Dimoglo
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AS
Chumakov
Y M
YM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004347:Drug Interactions; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D008968:Molecular Conformation; D021281:Quantitative Structure-Activity Relationship; D013210:Staphylococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D006834:Hydrazines