title: Inactive systemic lupus erythematosus id associated with a normal stimulated Th(1)/Th(2) cytokine secretory pattern.
abstract: OBJECTIVE
  To determine the Th(1)/Th(2)balance in systemic lupus erythematosus (SLE) patients with inactive disease.
  
  
  METHODS
  A comprehensive analysis of peak secretion, overall cytokine production and secretory pattern of Th(1)and Th(2)cytokines from stimulated PBMC of 10 SLE patients with inactive disease and 10 age- and sex-matched controls.
  
  
  RESULTS
  No significant differences were found in the peak and total secretion of all cytokines, as well as in the Th(1)and Th(2)secretory patterns and proliferative response between the two groups.
  
  
  CONCLUSIONS
  Th(1)and Th(2) balance in inactive SLE is normal.
authors.affiliation: Department "B" of Internal Medicine, Assaf Harofeh Medical Center, Zerifin, Israel. vazinam@post.tau.ac.il
authors.forename: M
authors.initials: M
authors.lastname: Amit
authors.forename: A
authors.initials: A
authors.lastname: Mor
authors.forename: J
authors.initials: J
authors.lastname: Weissgarten
authors.forename: R
authors.initials: R
authors.lastname: Rosenberg
authors.forename: Y
authors.initials: Y
authors.lastname: Ramot
authors.forename: A J
authors.initials: AJ
authors.lastname: Wysenbeek
authors.forename: M J
authors.initials: MJ
authors.lastname: Rapoport
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D007700:Kinetics; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*; D013997:Time Factors
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma