title: bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel.
authors.affiliation: Departments of Chemistry and Pharmacology, University College London, Gower Street, London WC1E 6BT, U.K.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Galanakis
authors.forename: C R
authors.initials: CR
authors.lastname: Ganellin
authors.forename: P M
authors.initials: PM
authors.lastname: Dunn
authors.forename: D H
authors.initials: DH
authors.lastname: Jenkinson
mesh_terms: D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology*; D002478:Cells, Cultured; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D011806:Quinolinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D051640:Small-Conductance Calcium-Activated Potassium Channels; D013329:Structure-Activity Relationship
chemical_list: C414209:8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D011806:Quinolinium Compounds; D051640:Small-Conductance Calcium-Activated Potassium Channels; D001030:Apamin; D002118:Calcium