Molecular motors and developmental asymmetry.
The generation of distinct cell fates can require movement of specific molecules or organelles to particular locations within the cell. These subcellular movements are often the jobs of motor proteins. Seemingly disparate developmental processes--determination of right and left in vertebrates, setting up the axes of polarity in insect embryos, mating-type switching in yeast, and coordinated organelle movements in Drosophila--converge in their dependence on motor proteins. The extent of possible regulatory complexity is only beginning to emerge.
Fischer
J A
JA
The University of Texas at Austin, Section of Molecular Cell and Developmental Biology, Institute for Cellular and Molecular Biology, Moffett Molecular Biology Building, 2500 Speedway, Austin, Texas 78712, USA. jaf@mail.utexas.edu
D000818:Animals; D001692:Biological Transport; D019521:Body Patterning / Q000235:genetics / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism / Q000502:physiology; D006801:Humans; D020409:Molecular Motor Proteins / Q000502:physiology*; D015388:Organelles / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism
D020409:Molecular Motor Proteins; D012333:RNA, Messenger