Lymphocyte peripheral benzodiazepine receptor mRNA decreases in obsessive-compulsive disorder.
The relative content of peripheral benzodiazepine receptor (pBR) mRNA was examined by reverse transcriptase-polymerase chain reaction in lymphocytes of obsessive-compulsive disorder (OCD) patients, according to their clinical course of illness. pBR mRNA significantly decreased only in chronic OCD patients (n=8) as compared to controls (n=10), whereas no significant changes were observed in episodic OCD patients (n=7). We suggest that modulation of pBR gene expression might delineate a clinical heterogeneity in OCD.
Rocca
P
P
Department of Neuroscience, Section of Psychiatry, University of Turin, via Cherasco 11, 10126 Torino, Italy. milani@molinette.unito.it
Beoni
A M
AM
Eva
C
C
Ferrero
P
P
Maina
G
G
Bogetto
F
F
Ravizza
L
L
D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000493:pharmacokinetics; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D012333:RNA, Messenger / Q000097:blood; D011963:Receptors, GABA-A / Q000097:blood / Q000235:genetics*; D014158:Transcription, Genetic
D007546:Isoquinolines; D012333:RNA, Messenger; D011963:Receptors, GABA-A; C037850:PK 11195