Synthesis and radiation stability of novel biologically active sulfur compounds derived from 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane.
Some novel 1,2-bis(s-triazolo[3,4b][1,3,4]thiadiazino-3-yl)ethane (4-7); 1,2-bis(s-triazolo[3,4b][1,3,4]thiadiazol-3-yl)ethane (16a,b) and 1,2-bis(s-triazolo[3,4b][1,3,4]thiadiazepino-3-yl)ethane (17) were synthesized via reaction of 1,2-bis(4-amino-5-mercapto-s-triazol-3-yl)ethane (3) with different reagents. Identification of the new compounds was established by elemental analyses, IR, 1H NMR and mass spectral data. Compounds 12, 13, 16b and 17 were promising antifungal activity. The biologically active compounds 13, 16b and 17 were radioresistant retaining their structures unchanged up to 40 k Gy. Radiosterilization of these compounds in the dry state may prove to be applicable.
Ghorab
M M
MM
Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt. ghorabmoustafa@hotmail.com
el-Sharief
A M
AM
Ammar
Y A
YA
Mohamed
S I
SI
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000528:radiation effects; D004355:Drug Stability; D005720:Gamma Rays; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis; D013242:Sterilization; D014230:Triazoles / Q000138:chemical synthesis* / Q000528:radiation effects
D000935:Antifungal Agents; D014230:Triazoles