title: Drug resistance rates of Mycobacterium tuberculosis strains in Austria between 1995 and 1998 and molecular typing of multidrug-resistant isolates. The Austrian Drug Resistant Tuberculosis Study Group.
abstract: In this study the drug resistance pattern of 3559 Mycobacterium tuberculosis strains isolated in Austria between 1995 and 98 was evaluated. Of these strains, 165 (4.6%) were resistant to one or more drugs, 113 (3.2%) to one of the tested drugs and 53 (1.5%) to two or more drugs. Monodrug resistance was observed most often to isoniazid (56 strains), followed by streptomycin (44 strains). Resistance to rifampicin or ethambutol alone was rarely seen (12 strains and 1 strain, respectively). Of the 53 strains resistant to 2 or more drugs, 25 were resistant to isoniazid and streptomycin, while 17 were multidrug resistant. Molecular typing revealed a large diversity among the multidrug-resistant strains.
authors.affiliation: National Reference Centre for Mycobacteria at the Federal Public Health Laboratory, Vienna, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Stauffer
authors.forename: A
authors.initials: A
authors.lastname: Makristathis
authors.forename: J P
authors.initials: JP
authors.lastname: Klein
authors.forename: W
authors.initials: W
authors.lastname: Barousch
mesh_terms: D000328:Adult; D001317:Austria; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D016133:Polymerase Chain Reaction; D015995:Prevalence
chemical_list: D004269:DNA, Bacterial