[The immune reactivity transfer factor as a modulator of lymphocyte functional activity in rats].
The transplantation of the thyroid tissue is one of the perspective methods for rehabilitation of thyroid gland functional disorders that appear due to the influence of insufficient environmental conditions on organism. By means of micromethod of lymphocyte blast transformation reaction on the base of [3H]-thymidine shift the functional activity of the Wistar rat's splenocytes was studied in case of radiation induced hypothyroidism with or without xenotransplantation of newborn pig thyroid gland organ culture. It was found that the level of thyroxine and triiodothyronine significantly decreased in serum of irradiated animals, the lymphocyte proliferation level was also reduced (by means of radioiodine introduction in dose of 8,325 MBk/mmole). Application of thyroid gland tissue xenotransplantate in this model of hypothyroidism helped to achieve the increasing of thyroid hormones levels in serum and rehabilitation of lymphocytes functional activity. The opportunities for correction of immunological disorders with the help of transfer factor of immune reactivity preparates were investigated. Transfer factor--is a low-molecular weight leukocyte extract (J 10 kD) with immunomodulating activities. This preparates activated the proliferation of splenocytes from animals with hypothyroidism and animals with hypothyroidism after xenotransplantation.
Holeva
O H
OH
Taras Shevhenko National University, Kiev.
Paster
I P
IP
Liubchenko
T A
TA
Paster
Ie U
IeU
Kholodna
L S
LS
Zamotaierva
H A
HA
Hrodzins'kyĭ
D M
DM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D000937:Antigen-Antibody Reactions / Q000187:drug effects* / Q000276:immunology; D007037:Hypothyroidism / Q000209:etiology / Q000276:immunology; D007457:Iodine Radioisotopes; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008970:Molecular Weight; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013552:Swine; D013961:Thyroid Gland / Q000637:transplantation; D013997:Time Factors; D014165:Transfer Factor / Q000494:pharmacology*; D014183:Transplantation, Heterologous
D000276:Adjuvants, Immunologic; D007457:Iodine Radioisotopes; D014165:Transfer Factor