[The effect of hypoxia of different origins and of the degree of its severity on the functional activity of the lysosomal apparatus].
We studied the activity of lysosomal enzymes (acid phosphatase and cathepsine D) and the status of lysosomal membranes of the liver, lung, heart and brain tissues of the male adult rats under acute hypoxia. We found that disturbances of lysosomal membranes permeability in these organs depend on the tissues hypoxia development, not yet on the genesis of hypoxic state. The lysosomal enzymes activation depends on the heaviness of the hypoxic influence.
Antonova
I I
II
A. A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Seredenko
M M
MM
Honchar
O O
OO
Koval'
S B
SB
Boiarchuk
O D
OD
D000135:Acid Phosphatase / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000503:physiopathology; D002402:Cathepsin D / Q000378:metabolism; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology*; D007425:Intracellular Membranes / Q000201:enzymology / Q000502:physiology; D008099:Liver / Q000201:enzymology / Q000503:physiopathology; D008168:Lung / Q000201:enzymology / Q000503:physiopathology; D008247:Lysosomes / Q000201:enzymology / Q000502:physiology*; D008297:Male; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar
D000135:Acid Phosphatase; D002402:Cathepsin D