title: High intensity focused ultrasound effect on cardiac tissues: potential for clinical application.
abstract: High intensity focused ultrasound (HIFU) is an evolving technology with potential therapeutic applications. Utilizing frequencies of 500 kHz to 10 MHz, HIFU causes localized hyperthermia at predictable depths without injuring intervening tissue. Applications in neurosurgery, urology, oncology and, more recently, cardiology for selective cardiac conduction tissue ablation have been promising. A 'noninvasive' technique for causing localized tissue damage to relieve hemodynamic and life-threatening obstruction in patients with congenital cardiac anomalies could replace more invasive procedures. We, therefore, investigated the ability of HIFU to create lesions in mammalian cardiac tissues ex vivo. Porcine valve leaflet, canine pericardium, human newborn atrial septum, and right atrial appendage were studied. Specimens were mounted and immersed in a water bath at room temperature. Using a 1-MHz phased array transducer, ultrasound energy was applied with an acoustic intensity of 1630 W/cm(2) or 2547 W/cm(2) until a visible defect was created (duration 3 to 25 sec). Macroscopic and microscopic examination demonstrated precise defects ranging from 3 to 4 mm in diameter. No damage was identified to the surrounding tissues. Our study concluded that HIFU can create precise defects in different cardiac tissue without damage to the surrounding tissue. Further investigation is needed to assess potential clinical uses of this technology.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, University of Michigan, Ann Arbor, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Lee
authors.forename: C
authors.initials: C
authors.lastname: Simon
authors.forename: E L
authors.initials: EL
authors.lastname: Bove
authors.forename: R S
authors.initials: RS
authors.lastname: Mosca
authors.forename: E S
authors.initials: ES
authors.lastname: Ebbini
authors.forename: G D
authors.initials: GD
authors.lastname: Abrams
authors.forename: A
authors.initials: A
authors.lastname: Ludomirsky
mesh_terms: D000818:Animals; D046508:Culture Techniques; D004285:Dogs; D006330:Heart Defects, Congenital / Q000628:therapy*; D006343:Heart Septal Defects / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D011664:Pulmonary Valve / Q000473:pathology* / Q000601:surgery*; D012680:Sensitivity and Specificity; D013552:Swine; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods*