title: Fixation-off sensitivity as a model of continuous epileptiform discharges: electroencephalographic, neuropsychological and functional MRI findings.
abstract: A case of fixation-off sensitivity (FOS) in an asymptomatic adult is presented and studied as a model for continuous epileptiform discharges. Video-electroencephalographic (EEG) revealed continuous bilateral occipital spike wave discharges during elimination of central vision, which were shown to be associated with transitory cognitive impairment demonstrated by neuropsychological testing. Functional MRI showed activation of parieto-occipital and frontal brain areas during the fixation-off discharges. This localization was confirmed with 64-channel EEG source analysis. The applied methods provided additional information on the pathophysiology of epileptiform discharges.
authors.affiliation: Epilepsy Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London, UK. k.krakow@em.uni-frankfurt.de
authors.forename: K
authors.initials: K
authors.lastname: Krakow
authors.forename: S A
authors.initials: SA
authors.lastname: Baxendale
authors.forename: E A
authors.initials: EA
authors.lastname: Maguire
authors.forename: E S
authors.initials: ES
authors.lastname: Krishnamoorthy
authors.forename: L
authors.initials: L
authors.lastname: Lemieux
authors.forename: C A
authors.initials: CA
authors.lastname: Scott
authors.forename: S J
authors.initials: SJ
authors.lastname: Smith
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D003071:Cognition / Q000502:physiology; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology*; D005403:Fixation, Ocular / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests