title: H(2)(15)O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans.
abstract: Steady-state arterial spin tagging approaches can provide quantitative images of CBF, but have not been validated in humans. The work presented here compared CBF values measured using steady-state arterial spin tagging with CBF values measured in the same group of human subjects using the H(2)(15)O IV bolus PET method. Blood flow values determined by H(2)(15)O PET were corrected for the known effects of incomplete extraction of water across the blood brain barrier. For a cortical strip ROI, blood flow values determined using arterial spin tagging (64+/-12 cc/100 g/min) were not statistically different from corrected blood flow values determined using H(2)(15)O PET (67+/-13 cc/100 g/min). However, for a central white matter ROI, blood flow values determined using arterial spin tagging were significantly underestimated compared to corrected blood flow values determined using H(2)(15)O PET. This underestimation could be caused by an underestimation of the arterial transit time for white matter regions.
authors.affiliation: Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: F Q
authors.initials: FQ
authors.lastname: Ye
authors.forename: K F
authors.initials: KF
authors.lastname: Berman
authors.forename: T
authors.initials: T
authors.lastname: Ellmore
authors.forename: G
authors.initials: G
authors.lastname: Esposito
authors.forename: J D
authors.initials: JD
authors.lastname: van Horn
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Duyn
authors.forename: A M
authors.initials: AM
authors.lastname: Smith
authors.forename: J A
authors.initials: JA
authors.lastname: Frank
authors.forename: D R
authors.initials: DR
authors.lastname: Weinberger
authors.forename: A C
authors.initials: AC
authors.lastname: McLaughlin
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001783:Blood Flow Velocity / Q000502:physiology*; D001834:Body Water / Q000000981:diagnostic imaging* / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply / Q000000981:diagnostic imaging; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D010104:Oxygen Radioisotopes / Q000032:analysis; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed
chemical_list: D010104:Oxygen Radioisotopes