title: Onychomycosis in children: treatment with bifonazole-urea.
abstract: We assessed the safety and efficacy of a two-phase topical treatment with bifonazole-urea ointment in children with onychomycosis. Twenty-five children younger than 16 years old with proved onychomycosis were included in the study. Bifonazole-urea ointment was administered under occlusion until the nontraumatic removal of the nail was achieved. Bifonazole cream was then applied for 4 weeks and a follow-up visit 4 weeks after cessation of medication was scheduled. During the study, periodic clinical and mycologic evaluations were carried out. Of the 25 patients included, 17 were cured (68%), 6 improved, and 2 failed treatment. The main etiologic agent isolated was Trichophyton rubrum (92%). Two patients had minor side effects, both during the occlusive phase, one each with mild pain and a probable dermatitis from the adhesive strips. Treatment was not discontinued in both of these cases. We concluded that a two-phase treatment with bifonazole-urea is effective and safe, and represents a new therapeutic choice for onychomycosis in children.
authors.affiliation: Mycology Department, Dermatology Service, Hospital General de Mexico, and Pediatric Dermatology Service, Hospital Infantil de Mexico, Mexico City, Mexico. bonayalx@servidor.unam.mx
authors.forename: A
authors.initials: A
authors.lastname: Bonifaz
authors.forename: G
authors.initials: G
authors.lastname: Ibarra
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000188:drug therapy / Q000382:microbiology; D006229:Hand Dermatoses / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D009779:Occlusive Dressings; D009824:Ointments; D014009:Onychomycosis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014249:Trichophyton / Q000187:drug effects / Q000302:isolation & purification; D014508:Urea / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D009824:Ointments; D014508:Urea; C036596:bifonazole