title: Cohibins C and D, two important metabolites in the biogenesis of acetogenins from Annona muricata and Annona nutans.
abstract: Two new annonaceous acetogenins, cohibins C (1a) and D (1b), have been isolated by extensive chromatography of a hexane extract of Annona muricata seeds and a cyclohexane extract of Annona nutans root bark. Their structures have been established on the basis of spectral evidence (NMR, MS) and confirmed by chemical transformation into a pair of monotetrahydrofuran (mono-THF) acetogenins. The role of these compounds in the biogenesis of mono-THF acetogenins is discussed.
authors.affiliation: Laboratoire de Pharmacognosie, UPRES-A CNRS 8076 (BioCIS), Faculté de Pharmacie, Université Paris XI, 92296 Châtenay-Malabry Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Gleye
authors.forename: S
authors.initials: S
authors.lastname: Raynaud
authors.forename: C
authors.initials: C
authors.lastname: Fourneau
authors.forename: A
authors.initials: A
authors.lastname: Laurens
authors.forename: O
authors.initials: O
authors.lastname: Laprévote
authors.forename: L
authors.initials: L
authors.lastname: Serani
authors.forename: A
authors.initials: A
authors.lastname: Fournet
authors.forename: R
authors.initials: R
authors.lastname: Hocquemiller
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism*; D005663:Furans / Q000378:metabolism*; D007783:Lactones / Q000378:metabolism*; D019684:Magnoliopsida / Q000378:metabolism*; D015394:Molecular Structure; D012639:Seeds / Q000378:metabolism; D013057:Spectrum Analysis
chemical_list: D005663:Furans; D007783:Lactones; C112079:isomurisolenin; C417924:cohibin C; C417925:cohibin D; D015107:4-Butyrolactone