title: Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula.
abstract: Six new metabolites have been isolated from a lyngbyastatin 2-producing strain of the marine cyanobacterium Lyngbya majuscula collected at Apra Harbor, Guam, and their structures elucidated. These linear lipopeptides have been assigned the trivial names apramides A-F (1-6). From a more recent collection of this cyanobacterium, a structurally related compound, apramide G (7), has been found instead of apramides A-F (1-6). Structure elucidation of the lipopeptides 1-7 is based on spectroscopic techniques and chiral chromatography of hydrolysis products. The apramides appear as NMR-spectroscopically distinguishable conformers in solution, and this has been ascribed to the presence of a thiazole-containing modified amino acid unit.
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.
authors.forename: H
authors.initials: H
authors.lastname: Luesch
authors.forename: W Y
authors.initials: WY
authors.lastname: Yoshida
authors.forename: R E
authors.initials: RE
authors.lastname: Moore
authors.forename: V J
authors.initials: VJ
authors.lastname: Paul
mesh_terms: D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D006141:Guam; D008074:Lipoproteins / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D008074:Lipoproteins