title: Genomic fold assignment and rational modeling of proteins of biological interest.
abstract: The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.
authors.affiliation: Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. M_Sauder@fccc.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Sauder
authors.forename: R L
authors.initials: RL
authors.lastname: Dunbrack
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D016678:Genome; D006801:Humans; D008958:Models, Molecular; D017510:Protein Folding; D011506:Proteins
chemical_list: D011506:Proteins