Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse.
Motor recovery after unilateral sensorimotor cortex ablation or sham-injury was measured in apolipoprotein E knockout and wild-type mice by testing their abilities to traverse a narrow beam. All mice trained without difficulty. Sham-operated mice performed perfectly regardless of genotype throughout testing. There was no difference in motor scores between lesioned apolipoprotein E knockout and wild-type mice on a first trial 24h after injury (P>0.05). There was a significant overall effect of lesion on motor performance (two-way repeated measures analysis of variance F(1,42)=304, P<0.0001), a significant time effect (F(17,714)=58, P<0.0001) and a lesion by time interaction (F(17,714)=58, P<0.0001). However, there was no effect of apolipoprotein E genotype group on recovery rate (i.e. there was no lesion group by genotype group by time interaction, F(17,714)=0.33, P=1.00) and no effect of genotype on the final level of motor performance 12 days after the lesion (Kruskal-Wallis H=5.79, P=0.12). These data suggest that motor recovery after unilateral injury to the sensorimotor cortex does not vary with apolipoprotein E genotype.
Goldstein
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LB
Department of Medicine (Neurology), Duke Center for Cerebrovascular Disease, Box 3651, Duke University Medical Center, Durham, NC 27710, USA. golds004@mc.duke.edu
Vitek
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MP
Dawson
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H
Bullman
S
S
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000502:physiology; D008124:Locomotion / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009044:Motor Cortex / Q000293:injuries* / Q000503:physiopathology; D004856:Postural Balance / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D013003:Somatosensory Cortex / Q000293:injuries* / Q000503:physiopathology
D001057:Apolipoproteins E