Variant LTC(4) synthase allele modifies cysteinyl leukotriene synthesis in eosinophils and predicts clinical response to zafirlukast.
Sampson
A P
AP
Division of Respiratory Cell and Molecular Biology Research, University of Southampton School of Medicine, Southampton, UK. aps@soton.ac.uk
Siddiqui
S
S
Buchanan
D
D
Howarth
P H
PH
Holgate
S T
ST
Holloway
J W
JW
Sayers
I
I
D000328:Adult; D000368:Aged; D000483:Alleles; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D003545:Cysteine / Q000096:biosynthesis*; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007211:Indoles; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D015289:Leukotrienes / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D048448:Phenylcarbamates; D011379:Prognosis; D015656:Respiratory Mechanics / Q000187:drug effects; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000627:therapeutic use*
D018927:Anti-Asthmatic Agents; D007211:Indoles; D020024:Leukotriene Antagonists; D015289:Leukotrienes; D048448:Phenylcarbamates; D013449:Sulfonamides; D014105:Tosyl Compounds; C112381:cysteinyl-leukotriene; D005982:Glutathione Transferase; C041116:leukotriene-C4 synthase; D003545:Cysteine; C062735:zafirlukast