title: [One case of Harada disease complicated by acute posterior multifocal placoid pigment epitheliopathy-like recurrence in both eyes].
abstract: BACKGROUND
  We encountered a patient who developed serous retinal detachment in one eye first, subsequently showed multiple small subretinal punctuated opacity looking like acute posterior multifocal placoid pigment epitheliopathy (APMPPE) in both eyes, and had repeated recurrence.
  
  
  METHODS
  A 28-year-old female presented with serous retinal detachment accompanied by multifocal small subretinal white punctuated opacity at the posterior pole of the fundus in the left eye. Fluorescein angiography (FAG) revealed many small punctuated hypofluorescent lesions scattered all over the eye in the early stage and multiple subretinal spotty leakage of fluorescein, subretinal accumulation of dye, and leakage of fluorescein from the optic disc in the late stage. Indocyanine green angiography (ICG) revealed small punctuated hypofluorescent lesions from the early to late stage in both eyes. The disease recurred five and a half months after, and there appeared many yellowish white round opaque parts and serous retinal detachment at the posterior pole in both eyes. FAG showed a reversal phenomenon of fluorescein in both eyes. On ICG many small punctuated hypofluorescent lesions were noted and in the late stage insular faint hypofluorescence consistent with serous retinal detachment, light tissue stain and fluorescent leakage in the center of the hypofluorescent lesion were also found. The disease recurred three times thereafter. At present, about two years after the first medical examination, the fundus does not show any sunset glow-like fundus, and vision of 1.2 is maintained on the right and left.
  
  
  CONCLUSIONS
  A rare case of Harada disease complicated with APMPPE-like recurrence is presented.
authors.affiliation: Department of Ophthalmology, Sapporo City General Hospital, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Furusho
authors.forename: H
authors.initials: H
authors.lastname: Imaizumi
authors.forename: M
authors.initials: M
authors.lastname: Takeda
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D012008:Recurrence; D012164:Retinal Diseases / Q000150:complications*; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications*