title: Drug-related cardiac iatrogenic illness as the cause for admission to the intensive cardiac care unit.
abstract: BACKGROUND
  Iatrogenic illness, defined as a disease that results from a diagnostic procedure or from any form of therapy, is a well-recognized phenomenon in clinical practice.
  
  
  OBJECTIVE
  To study and evaluate major cardiac iatrogenic disease as the cause of admission to the intensive cardiac care unit in the modern era.
  
  
  METHODS
  We assessed 64 critically ill patients suffering from major cardiac iatrogenic problems among a total of 2,559 patients admitted to the intensive cardiac care unit during 3 years. Iatrogenic illness was defined as any problem that resulted from therapy. Only cardiac problems were included in the study. Complications of interventional cardiovascular procedures, suicide attempts or accidental intoxications were excluded.
  
  
  RESULTS
  There was evidence of a major cardiac iatrogenic problem as the cause for admission in 64 patients (2.5%): 58 (91%) suffered from arrhythmias (mainly bradyarrhythmias) secondary to beta-blockers, amiodarone, calcium antagonists, electrolyte imbalance or a combination, and 6 (9%) had non-arrhythmic events (hypotension, syncope or acute heart failure). In 41 patients (64%) the iatrogenic event was considered preventable.
  
  
  CONCLUSIONS
  Major cardiac iatrogenic complications are an important factor among patients admitted to the intensive cardiac care unit. Most of the events are bradyarrhythmias related to anti-arrhythmic agents. Almost two-thirds of events are preventable.
authors.affiliation: Intensive Cardiac Care Unit, Rambam Medical Center, Haifa, Israel. h_hammerman@rambam.health.gov.il
authors.forename: H
authors.initials: H
authors.lastname: Hammerman
authors.forename: M
authors.initials: M
authors.lastname: Kapeliovich
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced*; D006760:Hospitalization; D006801:Humans; D007049:Iatrogenic Disease; D007362:Intensive Care Units; D007557:Israel; D008297:Male; D008875:Middle Aged