(S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain.
Song
Y
Y
Pfizer Global Research and Development, Ann Arbor Laboratories, Pfizer Inc., 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA.
Bowersox
S S
SS
Connor
D T
DT
Dooley
D J
DJ
Lotarski
S M
SM
Malone
T
T
Miljanich
G
G
Millerman
E
E
Rafferty
M F
MF
Rock
D
D
Roth
B D
BD
Schmidt
J
J
Stoehr
S
S
Szoke
B G
BG
Taylor
C
C
Vartanian
M
M
Wang
Y X
YX
D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000187:drug effects; D020864:Calcium Channels, N-Type / Q000187:drug effects; D002460:Cell Line; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010147:Pain Measurement; D010421:Pentanoic Acids / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
C414208:4-methyl-2-(methylamino)pentanoic acid (4, 4-bis(4-fluorophenyl)butyl)amide; D018712:Analgesics, Non-Narcotic; D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D020864:Calcium Channels, N-Type; D010421:Pentanoic Acids