Effect of ibuprofen upon hearing in the guinea pig.
The authors investigated the effect of varying doses of ibuprofen upon the hearing of guinea pigs monitored with brain stem-evoked response procedures. In daily dosages comparable on a weight basis to therapeutic levels in humans, ibuprofen was found not to have significant effects on response threshold or latency characteristics.
Koopmann
C F
CF
Department of Surgery, University of Arizona Health Sciences Center, Tucson 85724, USA.
Glattke
T A
TA
Caffrey
J D
JD
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001309:Auditory Threshold / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D006168:Guinea Pigs; D007052:Ibuprofen / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen