title: Physical training as an adjunct therapy in patients with congestive heart failure: patient selection, training protocols, results, and future directions.
abstract: Exercise intolerance in patients with chronic heart failure (CHF) shows no correlation to the degree of left ventricular dysfunction. This surprising finding has directed attention to peripheral changes in CHF: reduced endothelium-dependent vasodilation and altered skeletal muscle metabolism. Physical exercise training has evolved as an important therapeutic approach to influence these noncardiac causes of exercise intolerance. It has been shown to enhance the oxidative capacity of the working skeletal muscle, to attenuate ergoreflex activity, to correct endothelial dysfunction, and to improve ventilation. All exercise-induced adaptations converge to increase peak oxygen uptake by up to 2 mL/kg.min(-1). Uncertainty remains concerning optimal patient selection, training protocol, and long-term effects on cardiac function. For patients experiencing stable CHF while on optimal cardiac medication, a combination of in-hospital and home-based aerobic endurance training in combination with local muscle strength training seems most promising. Although exercise training offers no causal treatment of CHF, it has great potential as an adjunct therapy directed at improving exercise tolerance and expanding the physical limits of CHF patients.
authors.affiliation: Heart Center, Department of Internal Medicine/Cardiology, University of Leipzig, Leipzig, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Hambrecht
authors.forename: S
authors.initials: S
authors.lastname: Gielen
authors.forename: G
authors.initials: G
authors.lastname: Schuler
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology; D016757:Death, Sudden, Cardiac / Q000209:etiology; D005081:Exercise Therapy / Q000009:adverse effects; D005544:Forecasting; D006333:Heart Failure / Q000145:classification / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology; D012307:Risk Factors; D016019:Survival Analysis; D018754:Ventricular Dysfunction / Q000209:etiology