Yang-Gan-Wan protects mice against experimental liver damage.
The hepatoprotective effect of Yang-Gan-Wan (YGW, Pro-Liver pill), a Chinese herbal remedy, was investigated in mice that were treated with allyl alcohol (AlOH), acetaminophen (AA) or carbon tetrachloride (CCl4). Mice were pretreated daily with 200 mg/kg YGW for 10, 14 and 18 days before treatment with 85 mg/kg AlOH, 475 mg/kg AA or 20 microl/kg CCl4, respectively. YGW dramatically abolished the elevated activities of alanine aminotransferase (ALT) and sorbitol dehydrogenase (SDH) and reduced the necrosis induced by AlOH. YGW also decreased the elevated activities of ALT and SDH and reduced the necrosis induced by AA and CCl4. This study demonstrates that YGW has protective effects against liver damage induced by AlOH, AA, and CCl4.
Yang
M
M
University of Southern California, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, Los Angeles 90089, USA.
Chen
K
K
Shih
J C
JC
D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011042:Poisons / Q000633:toxicity; D020005:Propanols / Q000633:toxicity
D004365:Drugs, Chinese Herbal; D011042:Poisons; D020005:Propanols; C415597:Yang-Gan-Wan; D000082:Acetaminophen; C006463:allyl alcohol; D002251:Carbon Tetrachloride