title: Leukocytoclastic vasculitis complicating Klebsiella pneumoniae bacteremia.
abstract: A 79-year old woman, with a history of hypertension, presented with clinical features of congestive heart failure, fever, a purpuric rash, and left lower quadrant abdominal tenderness. Contrast computed tomography scan of the abdomen showed features of acute diverticulitis, and blood culture was subsequently positive for Klebsiella pneumoniae. Histological examination of a biopsy of the rash confirmed a diagnosis of leukocytoclastic vasculitis (LCV). The bacteremia responded to intravenous amoxycillin/clavulanic acid and gentamicin and the rash subsided. This case represents the first case of LCV complicating K. pneumoniae bacteremia in the English literature. The English literature on bacteria-associated LCV is reviewed. Taking aside organisms such as Rickettsia that cause endothelial invasion, the associated bacterial species tends to be subacute or chronic pathogens e.g. Mycoplasma pneumoniae, Mycobacterium tuberculosis, and Yersinia enterocolitica; or the disease process is of a subacute or chronic nature e.g. endocarditis, bronchiectesis, and cystic fibrosis, leading to prolonged exposure to pathogens that apparently cause acute pyogenic infections, such as K. pneumoniae.
authors.affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
authors.forename: P N
authors.initials: PN
authors.lastname: Lum
authors.forename: P C
authors.initials: PC
authors.lastname: Woo
authors.forename: S S
authors.initials: SS
authors.lastname: Wong
authors.forename: K
authors.initials: K
authors.lastname: Yuen
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D007710:Klebsiella Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D019818:Clavulanic Acid; D000658:Amoxicillin