Urinary soluble IL-6 receptor levels after cardiopulmonary bypass.
To investigate the possible role of soluble interleukin 6 receptor (sIL-6r) in the inflammatory response to cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC), we examined the levels of sIL-6r in the urine of 50 patients undergoing coronary artery bypass surgery. The presence of sIL-6r in urine was confirmed in these patients, with levels rising from 6 pg/ml preoperatively to 19.5 pg/ml at 6 h and 41 pg/ml at 24 h after the start of cardiopulmonary bypass. Cardiopulmonary bypass leads to a rise in sIL-6r in urine that has not returned to normal after 24 h, suggesting a role for sIL-6r and IL-6 in the inflammatory response to such surgery. Determination of cytokine receptor presence in urine offers a non-invasive approach to the monitoring of the immune and inflammatory response to the stress of surgical and traumatic injury.
Sutherland
A G
AG
Department of Orthopaedics, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Scotland. ort025@abdn.ac.uk
Deehan
D J
DJ
D000328:Adult; D000368:Aged; D015415:Biomarkers; D002315:Cardiopulmonary Bypass; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D019947:Receptors, Interleukin-6 / Q000096:biosynthesis*; D013997:Time Factors; D014556:Urine
D015415:Biomarkers; D019947:Receptors, Interleukin-6