title: The Epidural and Intrathecal Administration of Ketamine.
abstract: An overview of the spinal administration of ketamine is presented. Ketamine acts as a noncompetitive antagonist of the NMDA receptor Ca(++ channel pore. This effect provides interesting possibilities in pain therapy. However, there are still contrasting results that seem to be due to a lack of comparative controlled studies. The presence of systemic and neurotoxic effects presently limits clinical use).
authors.affiliation: Servizio di Anestesia e Rianimazione, Centro del Dolore, Ospedale S. Spirito, Via Vittorio Emanuele, 3, 12042 Bra, Italy. beltrutti@gem.it
authors.initials: DP
authors.lastname: Beltrutti
authors.initials: AC
authors.lastname: Trompeo
authors.lastname: Di Santo S