Receptor protein tyrosine phosphatases in hematopoietic cells.
PTPs and PTKs control the level of tyrosine phosphorylation of cellular proteins. Although many substrates for PTKs have been identified, the specific targets of individual PTP family members, along with the consequences of protein dephosphorylation for cellular physiology, remain largely unknown. Fine regulation of tyrosine phosphorylation events is required for the proper progression of hematopoiesis. In this review, we have summarized the characterization of tyrosine phosphatases in hematopoietic cells and delineated their potential role in the process of hematopoiesis and the development of hematopoietic disorders.
Avraham
H
H
Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA. havraham@caregroup.harvard.edu
Avraham
S
S
Taniguchi
Y
Y
D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000201:enzymology* / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000201:enzymology / Q000503:physiopathology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*
D020794:Receptor Protein-Tyrosine Kinases