Streptazones A, B(1), B(2), C, and D: new piperidine alkaloids from streptomycetes.
Five new piperidine alkaloids (1-5), named streptazones A, B(1), B(2), C, and D, were isolated from Streptomyces strains FORM5 and A1. Their structures were established on the basis of detailed MS and NMR analysis. Streptazone A (1) exhibited significant cytotoxic activity against selected human tumor cell lines.
Puder
C
C
Institut für Organische Chemie, Universität Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Krastel
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P
Zeeck
A
A
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010880:Piperidines / Q000737:chemistry*; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000970:Antineoplastic Agents; D010880:Piperidines