Urokinase stimulates differentiation of fibroblasts into myofibroblasts and their proliferation in damaged adventitia.
Urokinase expression in the adventitia of rat common carotid artery increased on the 4th day after periadventitial damage. Periadventitial application of recombinant urokinase increased the area of the adventitia and the content of contractile and proliferating cells, while proteolytically inactive recombinant urokinase was ineffective.
Plekhanova
O S
OS
Russian Cardiological Research-and-Production Complex, Russian Ministry of Health, Moscow. plekhanova @mail.ru
Volynskaya
E A
EA
Kalinina
N I
NI
Parfenova
E V
EV
D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D002454:Cell Differentiation / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology*; D008297:Male; D010960:Plasminogen Activators / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*; D014661:Vasoconstriction
D011994:Recombinant Proteins; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator