[Proteinase-proteinase inhibitor complex in rats under oxidative stress caused by administration of cobalt chloride].
Mechanisms of proteinase-inhibitor proteinase system response was estimated following of cobalt chloride injection. The increase proteinase activity, which led to significant decrease of alpha-2-macroglobulin (alpha-2-MG) level was established that indicated to the removal of the proteinase in complex with alpha-2-MG from the organism. Increase of alpha-1-proteinase inhibitor (alpha-1-PI) trypsin-inhibitory activity in the kidneys testify about removal of oxidative alpha-1-PI.
Kaliman
P A
PA
Kharkov State University.
Samokhin
A A
AA
Samokhina
L M
LM
D000818:Animals; D003035:Cobalt / Q000494:pharmacology*; D010450:Endopeptidases / Q000097:blood*; D007668:Kidney / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D003035:Cobalt; D010450:Endopeptidases; C018021:cobaltous chloride