Bioactive constituents of Chinese natural medicines. V. Radical scavenging effect of Moutan Cortex. (1): Absolute stereostructures of two monoterpenes, paeonisuffrone and paeonisuffral.
The methanolic extract and the ethyl acetate-soluble and methanol-eluted fractions from Chinese Moutan Cortex, the roots of Paeonia suffruticosa ANDREWS, were found to exhibit scavenging effect on 1,1-diphenyl-2-picrylhydrazyl radical and superoxide anion radical generated by the xanthine-xanthine oxidase system. Two monoterpenes called paeonisuffrone and paeonisuffral were isolated from the ethyl acetate-soluble fraction. Their absolute stereostructures were elucidated on the basis of chemical and physiochemical evidence, which included the application of a modified Mosher's method and lipase catalyzed debenzoylation reaction.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan. shoyaku@mb.kyoto-phu.ac.jp
Ohta
T
T
Kawaguchi
A
A
Matsuda
H
H
D015764:Bepridil / Q000031:analogs & derivatives / Q000737:chemistry; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D039821:Monoterpenes; D010851:Picrates; D018517:Plant Roots / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification
D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D039821:Monoterpenes; D010851:Picrates; D013729:Terpenes; C419235:paeonisuffral; C419234:paeonisuffrone; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl