[Antioxidant effectiveness of short-chain alpha-tocopherol acetate in acute paracetamol poisoning in rats].
In the experiments in vivo on white rats possibility of paracetamol hepatotoxic effects correction with synthetic short-chain alpha-tocopherol derivative and pharmacopeial preparation of vitamin E has been studied. Levels of superoxide anion generation in liver mitochondria fraction, catalase activity and reduced glutathione, serum aminotransferase and alcaline phosphatase activities and liver subcellular fractions lipid contents were investigated. It was shown that the short-chain vitamin E derivative and pharmacopeial preparation had a membranotropic effect, normalizing free and total cholesterol levels in liver mitochondria fraction and decreasing serum aminotransferase activity level. Investigated compounds also decreased levels of superoxide anions generation, increased catalase activity and level of reduced glutathione in liver. Antioxidative properties of this derivative and pharmacopeial preparation were demonstrated both at the primary (dienes, trienes) and at final steps of lipid peroxidation (TBA-products formation). This antioxidative activity of alpha-tocopherol acetate and its derivative depended on the structure of chromane cycle but not on the length of side chain.
Shaiakhmetova
H M
HM
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv.
Kovalenko
V M
VM
Bondarenko
L B
LB
Kuz'menko
I V
IV
D000082:Acetaminophen / Q000506:poisoning*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D024505:Tocopherols; D000637:Transaminases / Q000097:blood; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D014810:Vitamin E; D000082:Acetaminophen; D002374:Catalase; D000637:Transaminases; D005978:Glutathione; D024502:alpha-Tocopherol; D024505:Tocopherols