title: Involvement of bone marrow fibroblasts in the recovery of granulocytopoiesis after cytostatic-induced myelosuppression.
abstract: The effects of anticancer drugs whose action is mediated by different mechanisms on activity of bone marrow fibroblasts and their role in the regulation of granulocytopoiesis recovery after cytostatic treatment were studied. The antimetabolite 5-fluorouracil strongly suppressed, while the anthracycline antibiotic adriamycin and the alkylating agent cyclophosphamide stimulated function of stromal cells. This largely accounted for different dynamics of recovery of the bone marrow neutrophil lineage.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygaii
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: N S
authors.initials: NS
authors.lastname: Pozhen'ko
authors.forename: L A
authors.initials: LA
authors.lastname: Gur'yantseva
authors.forename: E D
authors.initials: ED
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000473:pathology* / Q000502:physiology; D002454:Cell Differentiation; D005347:Fibroblasts / Q000473:pathology* / Q000502:physiology; D006098:Granulocytes / Q000473:pathology* / Q000502:physiology; D006410:Hematopoiesis; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
chemical_list: D000970:Antineoplastic Agents