Lipid peroxidation and activities of antioxidant enzymes in the diabetic kidney: effect of treatment with angiotensin convertase inhibitors.
Effects of the angiotensin convertase inhibitors captopril (CAP) and enalapril (ENA) on the malondialdehyde (MDA) content and the activities of superoxide dismutase (SOD) and catalase in the kidneys of rats with streptozotocin-induced diabetes were studied. Induction of diabetes resulted in an increase of MDA concentration and progressive decreases of SOD and catalase activities after 6 and 12 weeks. CAP and ENA administration did not affect body weight changes or blood glucose and HbA1c contents in diabetic rats but decreased albuminuria and kidney weight increase, attenuated lipid peroxidation, and prevented the decreases in SOD and catalase activities. These results confirm the oxidative stress in streptozotocin-induced experimental diabetes and point to the beneficial antioxidant effects of angiotensin convertase inhibitors.
Kedziora-Kornatowska
K Z
KZ
Department of Internal Diseases, Military Medical University, Lodz, Poland.
Luciak
M
M
Paszkowski
J
J
D000419:Albuminuria; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose; D002216:Captopril / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000201:enzymology*; D004656:Enalapril / Q000494:pharmacology; D006441:Hemoglobin A / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D001786:Blood Glucose; D008315:Malondialdehyde; D004656:Enalapril; D006441:Hemoglobin A; D002216:Captopril; D002374:Catalase; D013482:Superoxide Dismutase; D007703:Peptidyl-Dipeptidase A