[The immune response of viral hepatitis patients who use narcotic preparations].
The characteristics of cell-mediated and humoral immunity were studied in 611 patients with different etiological forms of acute virus hepatitides (HB, HC, HB + C, HC + HBsAg). As the result of the systematic abuse of psychoactive preparations, introduced by intravenous injection, in 166 patients (27.2%) drug addiction developed, ehile 445 (72.8%) patients had no addiction. The study revealed that in drug users with HB the secondary T-cell immunodeficiency of the hyposuppressor type in combination with depression in B-cell-mediated immunity (a decrease in the absolute number of B lymphocytes) could be registered, and in patients having no drug addiction the secondary T-cell immunodeficiency characterized by a decrease in the content of T helpers simultaneously with the increased content of T suppressors and B lymphocytes.
Starostina
I S
IS
Research Institute of Epidemiology and Microbiology, Territorial Mental Health Center, Khabarovsk, Russia.
Bogach
V V
VV
Trotsenko
O E
OE
Mikhaĭlov
V I
VI
Tomilka
G S
GS
Balakhontseva
L A
LA
Durneva
V M
VM
Kotov
V O
VO
Fomenko
V V
VV
Sokolovskiĭ
L M
LM
D000208:Acute Disease; D000704:Analysis of Variance; D000917:Antibody Formation; D001782:Blood Donors; D006509:Hepatitis B / Q000276:immunology*; D006526:Hepatitis C / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D015999:Multivariate Analysis; D009293:Opioid-Related Disorders / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology