[Analysis using ELISA test of antibody response to Fusobacterium nucleatum and Eikenella corrodens in subjects with periodontal disease].
BACKGROUND
To know the synthesis of IgG, IgA, and IgM to Fusobacterium nucleatum and Eikenella corrodens in serum, crevicular liquid and saliva in subjects with periodontal disease, using ELISA test.


METHODS
We studied 26 patients with high bias to the disease aged less than 35 years and 30 individuals with comparable age and with scarce bias to the disease.


RESULTS
No differences were found for IgG and IgM titers between the groups, except for IgM to E. corrodens. For IgA, differences were found when the saliva and crevicular liquid were studied for both bacteria, as occurred in serum IgA compared to E. corrodens. In all the cases antibody levels were lower in the patients.


CONCLUSIONS
The lower synthesis of IgM and IgA, fundamentally the latter, to F. nucleatum and E. corrodens in patients with periodontal disease would contribute to the pathogenesis of this illness.
Gutiérrez
J
J
Departamento de Estomatología, Universidades de Granada y Oviedo, Hospital Universitario San Cecilio. josegf@goliat.ugr.es
Guerrero
R
R
Noguerol
B
B
Menéndez
M
M
Liébana
J
J
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000097:blood; D000917:Antibody Formation; D016124:Eikenella corrodens / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D016967:Fusobacterium nucleatum / Q000276:immunology*; D005883:Gingival Crevicular Fluid / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D007075:Immunoglobulin M / Q000032:analysis / Q000097:blood; D010510:Periodontal Diseases / Q000209:etiology / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D013053:Spectrophotometry
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M