The role of radiation in the management of Hodgkin's disease: an update.
RT is the most effective single agent in HD, and it has many roles in the management of this disease. These roles include RT as the sole curative agent in early stage HD in adults and in limited nodal recurrences in patients previously treated with CT alone; RT as the primary treatment for clinical and subclinical disease in CMT regimens using minimal adjuvant CT; RT as an integral part of standard and high-dose CMT regimens used to consolidate CT responses in all sites of clinical involvement; and RT as an adjuvant to CT for areas of bulky disease or incomplete CT response. Its effectiveness depends on the clinical expertise of the treating physician, the adequacy of the staging studies, and the accuracy of the treatment technique.
Mendenhall
N P
NP
Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, USA.
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D006689:Hodgkin Disease / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D015182:Lymphatic Irradiation; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods; D011879:Radiotherapy Dosage; D016879:Salvage Therapy; D017211:Treatment Failure