title: Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats.
abstract: We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures.
authors.affiliation: Department of Neurology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Enders #320, Boston, MA 02115, USA. silveira@a1.tch.harvard.edu
authors.forename: D C
authors.initials: DC
authors.lastname: Silveira
authors.forename: G L
authors.initials: GL
authors.lastname: Holmes
authors.forename: S C
authors.initials: SC
authors.lastname: Schachter
authors.forename: C
authors.initials: C
authors.lastname: Geula
authors.forename: D L
authors.initials: DL
authors.lastname: Schomer
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D003292:Convulsants; D003714:Denervation; D004198:Disease Susceptibility; D004829:Epilepsy, Generalized / Q000139:chemically induced*; D005481:Flurothyl; D000922:Immunotoxins / Q000494:pharmacology*; D008297:Male; D009699:N-Glycosyl Hydrolases; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D010433:Pentylenetetrazole; D010940:Plant Proteins / Q000494:pharmacology*; D016548:Prosencephalon / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D054789:Ribosome Inactivating Proteins, Type 1; D000076985:Saporins
chemical_list: D003292:Convulsants; D000922:Immunotoxins; D010940:Plant Proteins; D054789:Ribosome Inactivating Proteins, Type 1; D005481:Flurothyl; D000110:Acetylcholinesterase; D009699:N-Glycosyl Hydrolases; D000076985:Saporins; D010433:Pentylenetetrazole