title: Renal Doppler sonographic and histologic findings in post-transplant primary cytomegalovirus disease.
abstract: Cytomegalovirus (CMV) infections frequently develop in renal transplant patients. The transplanted kidney may be not only the source of infection but also the target for it. We report a case of primary CMV infection in a seronegative patient who received a graft from a seropositive cadaveric donor. The onset of CMV was clinically apparent on post-transplant day 22. Interestingly, soon after transplantation, the patient developed a long-lasting graft dysfunction episode for which diffuse endothelial-cell swelling was the most relevant finding at biopsy. On sonography, renal graft vascular impedance deteriorated and improved repeatedly during the follow-up period. We postulate that the patient had CMV-induced immunogenic-mediated endothelial-cell injury.
authors.affiliation: Center for Experimental Surgery, University of Zulia, Apartado Postal 1430, Maracaibo 4001-A, Venezuela.
authors.forename: O J
authors.initials: OJ
authors.lastname: Salgado
authors.forename: C
authors.initials: C
authors.lastname: Henríquez
authors.forename: B
authors.initials: B
authors.lastname: Rosales
authors.forename: M G
authors.initials: MG
authors.lastname: Martín
authors.forename: R
authors.initials: R
authors.lastname: García
authors.forename: B
authors.initials: B
authors.lastname: Rodríguez-Iturbe
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003586:Cytomegalovirus Infections / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000008:administration & dosage; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
chemical_list: D015774:Ganciclovir