[ret/PtC1 and ret/PTC3r1 rearrangement in thyroid cancer cells, arising in residents of Belorus in the period after the accident at the Chernobyl nuclear power plant].
After the accident at the Chernobyl nuclear power plant, a considerable increase in the incidence of thyroid cancer among children in Belarus was observed. In the present study, the frequency of the c-ret protooncogene rearrangements in samples of thyroid carcinomas resected and diagnosed in 1998 from individuals in Belarus was investigated. The ret/PTC1 oncogene was detected in 19% of the samples, and the ret/PTC3r1 oncogene, in 14%. The number of ret/PTC1 rearrangements observed in tumor cells from the patients whose age at the time of the accident was from 1 to 10 years, was greater compared to those whose age at the time was from 10 to 20 years, irrespective of the year of surgery (1996 or 1998). The majority of the patients with ret/PTC3r1 rearrangements lived in Gomel oblast, which was contaminated by the Chernobyl meltdown.
Pisarchik
A V
AV
Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk, Belarus.
Iarmolinskiĭ
D G
DG
Demidchik
Iu E
IuE
Ermak
G Z
GZ
Kartel'
N A
NA
Figge
J
J
D002648:Child; D015321:Gene Rearrangement; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D056918:Nuclear Receptor Coactivators; D015513:Oncogene Proteins / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011210:Power Plants; D011505:Protein-Tyrosine Kinases; D018788:Radioactive Hazard Release; D013964:Thyroid Neoplasms / Q000209:etiology / Q000235:genetics*; D014157:Transcription Factors; D014455:Ukraine
C111382:NCOA4 protein, human; D056918:Nuclear Receptor Coactivators; D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases; C093573:ret-PTC fusion oncoproteins, human