title: Pathogenesis and current management of gastrooesophageal-reflux-related asthma.
abstract: In the past decade the use of proton pump inhibitors on the one hand, and an aggressive surgical approach on the other hand have revolutionised the treatment of gastro-oesophageal reflux disease (GORD). Many studies have suggested that the successful management of GORD results in improvement of the symptoms of asthma which coexist in many of these patients. In this paper we review the pathogenesis and the medical and surgical treatment of GOR-related asthma. Both anti-reflux operations and anti-acid medications improve GORD and GOR-related asthma. Although anti-reflux surgery is superior to H2 blockers, there are not sufficient data to evaluate proton pump inhibitors compared with operation in controlling the symptoms of asthma.
authors.affiliation: Department of Surgery, Rabin Medical Center, Petah Tikva, Israel.
authors.forename: T
authors.initials: T
authors.lastname: Menes
authors.forename: S
authors.initials: S
authors.lastname: Lelcuk
authors.forename: H
authors.initials: H
authors.lastname: Spivak
mesh_terms: D001249:Asthma / Q000209:etiology*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D009853:Omeprazole / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D011899:Ranitidine / Q000627:therapeutic use
chemical_list: D004791:Enzyme Inhibitors; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D009853:Omeprazole