Topical delta-aminolevulinic acid-based photodynamic therapy for Japanese actinic keratoses.
Based on the opinion that 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) may be disadvantageous to Oriental patients with dark skin, including Japanese, because the competing chromophore melanin inhibits the photochemical reaction, we assessed the therapeutic effects when Japanese AK were treated with ALA-PDT. Fifty-three lesions in ten patients were followed up for over one year. The cure rates of AK on the face including the neck and on extremities were 81.8% and 55.6%, respectively. The results were approximately the same cure rates as those reported for AK in Caucasian patients. However, a larger number of treatment sessions were required. In the red light range, incoherent light including 630 nm and 670 nm is superior to 630 nm laser light.
Itoh
Y
Y
Department of Dermatology, National Defense Medical College, Tokorozawa, Japan.
Ninomiya
Y
Y
Henta
T
T
Tajima
S
S
Ishibashi
A
A
D000368:Aged; D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D001132:Arm; D044466:Asian People / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000235:genetics; D005148:Facial Dermatoses / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006801:Humans; D007564:Japan; D007642:Keratosis / Q000188:drug therapy* / Q000235:genetics; D007866:Leg; D008297:Male; D009333:Neck; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000235:genetics; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000235:genetics; D016896:Treatment Outcome
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid