Kasumigamide, an antialgal peptide from the cyanobacterium Microcystis aeruginosa.
Kasumigamide (1), a novel antialgal tetrapeptide containing an N-terminal alpha-hydroxy acid, was isolated from the freshwater cyanobacterium Microcystis aeruginosa (NIES-87). Its structure was elucidated by two-dimensional (1)H-(1)H and (1)H-(13)C NMR correlation experiments and confirmed by mass spectral and amino acid analyses. The absolute stereochemistry of 1 was determined by chemical studies. This peptide showed an antialgal activity against the green alga Chlamydomonas neglecta (NIES-439).
Ishida
K
K
Laboratory of Marine Biochemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
Murakami
M
M
D000596:Amino Acids / Q000032:analysis; D000460:Chlorophyta / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D046931:Microcystis / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D010575:Pesticides / Q000138:chemical synthesis* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000596:Amino Acids; D009842:Oligopeptides; D010575:Pesticides; C415189:kasumigamide