title: CCK receptor polymorphisms: an illustration of emerging themes in pharmacogenomics.
abstract: Polymorphisms in G-protein-coupled receptors can alter drug affinity and/or activity. In addition, genetic differences in amino acid sequences can induce ligand-independent signaling, which in turn can lead to disease. With growing efforts in the field of pharmacogenomics, it is anticipated that polymorphism-induced alterations in drug and/or receptor function will be a focus of increasing concern during the course of future drug-development efforts. In this review, the spectrum of pharmacological consequences that result from polymorphisms in the cholecystokinin CCK2 receptor will be discussed, thereby illustrating emerging themes in pharmacogenomics.
authors.affiliation: Department of Medicine and the GRASP Digestive Disease Center, Tupper Research Institute, New England Medical Center, 750 Washington Street, Boston, MA 02111, USA. akopin@msn.com
authors.forename: A S
authors.initials: AS
authors.lastname: Kopin
authors.forename: E W
authors.initials: EW
authors.lastname: McBride
authors.forename: K
authors.initials: K
authors.lastname: Schaffer
authors.forename: M
authors.initials: M
authors.lastname: Beinborn
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000235:genetics / Q000502:physiology*; D011949:Receptors, Cholecystokinin / Q000235:genetics / Q000502:physiology*; D013045:Species Specificity
chemical_list: D011949:Receptors, Cholecystokinin; D019204:GTP-Binding Proteins