title: Effect of dietary advice and n-3 supplementation in newly diagnosed MS patients.
abstract: OBJECTIVE
  To investigate whether supplementation with fish oil given together with dietary advice and vitamin supplementation influenced the clinical outcome in newly diagnosed multiple sclerosis (MS) patients.
  
  
  METHODS
  Sixteen consecutive, newly diagnosed patients with multiple sclerosis were recruited to an open intervention study. They were given dietary advice and supplemented with 0.9 g/day of long-chain marine fatty acids and vitamins. The patients were followed for 2 years with respect to dietary habits, blood parameters and neurological assessment including exacerbation rate.
  
  
  RESULTS
  There was a significant reduction in the mean annual exacerbation rate and the mean Expanded Disability Status Scale (EDSS) as compared to pre-study values. The plasma total phospholipid n-3 fatty acids increased and n-6 fatty acids decreased significantly.
  
  
  CONCLUSIONS
  The results suggest that fish oil supplementation given together with vitamins and dietary advice can improve clinical outcome in patients with newly diagnosed MS.
authors.affiliation: Department of Neurology, Haukeland University Hospital, Bergen, Norway.
authors.forename: I
authors.initials: I
authors.lastname: Nordvik
authors.forename: K M
authors.initials: KM
authors.lastname: Myhr
authors.forename: H
authors.initials: H
authors.lastname: Nyland
authors.forename: K S
authors.initials: KS
authors.lastname: Bjerve
mesh_terms: D000208:Acute Disease; D000328:Adult; D018752:Diet, Fat-Restricted; D015525:Fatty Acids, Omega-3 / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood / Q000178:diet therapy*; D010353:Patient Education as Topic; D010743:Phospholipids / Q000097:blood; D011446:Prospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome; D014815:Vitamins / Q000097:blood / Q000627:therapeutic use*
chemical_list: D015525:Fatty Acids, Omega-3; D010743:Phospholipids; D014815:Vitamins