title: Serotonin and pancreatic duct function.
abstract: 1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
authors.affiliation: Internal Medicine II, Nagoya University School of Medicine, Japan. snaruse@med.nagoya-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Naruse
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Ishiguro
authors.forename: M
authors.initials: M
authors.lastname: Kitagawa
authors.forename: S B
authors.initials: SB
authors.lastname: Ko
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: A
authors.initials: A
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
mesh_terms: D008735:5-Methoxytryptamine / Q000494:pharmacology; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006168:Guinea Pigs; D010183:Pancreatic Ducts / Q000187:drug effects / Q000378:metabolism*; D012633:Secretin / Q000494:pharmacology; D012701:Serotonin / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D012633:Secretin; D012701:Serotonin; D008735:5-Methoxytryptamine; C045918:2-methyl-5-HT; D000109:Acetylcholine; D002118:Calcium