title: Intrinsic resistance of Mycobacterium tuberculosis to clarithromycin is effectively reversed by subinhibitory concentrations of cell wall inhibitors.
abstract: Subinhibitory concentrations of bacitracin, vancomycin and other inhibitors of cell wall synthesis reversed to varying extents the intrinsic resistance of Mycobacterium tuberculosis to clarithromycin. Ethambutol reversed clarithromycin resistance in all of the M. tuberculosis strains studied regardless of their susceptibility to this drug.
authors.affiliation: Centro de Malária e outras Doenças Tropicais, Instituto de Higiéne e Medicina Tropical, Universidade Nova de Lisboa, Portugal. suzanadavid@ihmt.unl.pt
authors.forename: S
authors.initials: S
authors.lastname: Bosne-David
authors.forename: V
authors.initials: V
authors.lastname: Barros
authors.forename: S C
authors.initials: SC
authors.lastname: Verde
authors.forename: C
authors.initials: C
authors.lastname: Portugal
authors.forename: H L
authors.initials: HL
authors.lastname: David
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology; D002473:Cell Wall / Q000187:drug effects* / Q000378:metabolism; D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004977:Ethambutol / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D014376:Tuberculosis / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D004977:Ethambutol; D017291:Clarithromycin