title: Health-related quality of life in survivors of Wilms' tumor and advanced neuroblastoma: aA cross-sectional study.
abstract: OBJECTIVE
  In pediatric oncology, Wilms' tumor and advanced neuroblastoma represent opposite ends of the spectra of survival probability and therapeutic intensity. Consequently, it was envisaged that survivors of Wilms' tumor would enjoy better health status and health-related quality of life (HRQL) than survivors of advanced neuroblastoma.
  
  
  METHODS
  Health status questionnaires were sent to the parents of all eligible children and to the children themselves if they were > or = 8 years of age. Responses were received from 84% of 93 eligible families. Responses were converted by established algorithms into levels of two multiattribute health status classification systems known as Health Utilities Index Mark 2 and Mark 3. These systems are linked to measures of preference, in the form of multiattribute utility functions, which provide scores of morbidity for single-attribute levels and of global HRQL for comprehensive health states.
  
  
  RESULTS
  A greater burden of morbidity was identified in the survivors of advanced neuroblastoma than in survivors of Wilms' tumor based on the assessments of the parents of these children. In particular, survivors of advanced neuroblastoma exhibited deficits in hearing and speech. It is possible that this morbidity burden reflects the prevalent use of platinum compounds (causing ototoxicity) in this group. Within parent-child dyads there was a high level of percentage agreement on responses in all attributes except cognition.
  
  
  CONCLUSIONS
  Extension of this study to a larger sample size of patients will provide clarification of these observations.
authors.affiliation: Health Sciences Center, McMaster University, Hamilton, Ontario, Canada.rbarr@fhs.csu.mcmaster.ca
authors.forename: R D
authors.initials: RD
authors.lastname: Barr
authors.forename: D
authors.initials: D
authors.lastname: Chalmers
authors.forename: S
authors.initials: S
authors.lastname: De Pauw
authors.forename: W
authors.initials: W
authors.lastname: Furlong
authors.forename: S
authors.initials: S
authors.lastname: Weitzman
authors.forename: D
authors.initials: D
authors.lastname: Feeny
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009017:Morbidity; D009447:Neuroblastoma / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D011788:Quality of Life; D011795:Surveys and Questionnaires; D009396:Wilms Tumor / Q000150:complications / Q000453:epidemiology / Q000628:therapy