title: Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein.
abstract: Transient intracellular expression of ExoT in CHO cells stimulated cell rounding and actin reorganization. Biochemical studies showed that ExoT was a GTPase-activating protein for RhoA, Rac1, and Cdc42. Together, these data show that ExoT interferes with Rho signal transduction pathways, which regulate actin organization, exocytosis, cell cycle progression, and phagocytosis.
authors.affiliation: Medical College of Wisconsin, Microbiology and Molecular Genetics, Milwaukee, Wisconsin 53226, USA.
authors.forename: R
authors.initials: R
authors.lastname: Krall
authors.forename: G
authors.initials: G
authors.lastname: Schmidt
authors.forename: K
authors.initials: K
authors.lastname: Aktories
authors.forename: J T
authors.initials: JT
authors.lastname: Barbieri
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003603:Cytotoxins / Q000235:genetics* / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000472:pathogenicity*; D014162:Transfection
chemical_list: D000199:Actins; D003603:Cytotoxins; D020690:GTPase-Activating Proteins; C085379:rho GTPase-activating protein