Natural product derived inhibitors of lipoprotein associated phospholipase A2, synthesis and activity of analogues of SB-253514.
The synthesis of analogues of SB-253514, a novel natural product derived inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), is described together with their ability to inhibit Lp-PLA2.
Pinto
I L
IL
SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK. ivan_pinto-l@sbphrd.com
Boyd
H F
HF
Hickey
D M
DM
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D011714:Pyrans; C414127:SB 253514; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase