title: Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration.
abstract: Pharmacokinetics of GVS-111, a new acylprolyldipeptide with nootropic properties and its penetration across the blood-brain barrier were studied in rats using HPLC. It was found that the dipeptide is absorbed in the gastrointestinal tract, enters the circulation, and penetrates through the blood-brain barrier in an unmodified state.
authors.affiliation: Laboratory of Pharmacokinetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
authors.forename: S S
authors.initials: SS
authors.lastname: Boiko
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaya
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: S A
authors.initials: SA
authors.lastname: Korotkov
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D004151:Dipeptides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D018697:Nootropic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats
chemical_list: D004151:Dipeptides; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly