title: Preparation and antidiabetic activity of new substituted 3,5-diarylpyrazolesulfonylurea derivatives. II: Structure-activity relationship.
abstract: Four series of substituted p-(3,5-diaryl-2-pyrazoline-1) benzenesulfonylurea and thiourea derivatives, along with their corresponding substituted p-(3,5-diarylpyrazole-1) benzenesulfonylurea and thiourea derivatives, were prepared for evaluation as hypoglycemic agents. Preliminary biological testing revealed that the new compounds possess potent hypoglycemic activity.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, University of Alexandria, Egypt.
authors.forename: R
authors.initials: R
authors.lastname: Soliman
authors.forename: H M
authors.initials: HM
authors.lastname: Faid-Allah
authors.forename: S K
authors.initials: SK
authors.lastname: el-Sadany
mesh_terms: D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013329:Structure-Activity Relationship; D013453:Sulfonylurea Compounds / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; D000496:Alloxan