title: A case of probable acute interstitial pneumonia with a dramatic response to pulse corticosteroid administration.
abstract: A 38-year-old Japanese male without any significant respiratory risk factors was admitted to our hospital because of an acute onset of fulminant pneumonia refractory to intravenous antibiotics administration and an unexplained creatine kinase elevation. He was intubated and under ventilator support on the second hospital day, but responded dramatically to i.v. pulse methylprednisone treatment. After exclusion of secondary etiologies including collagen diseases, we concluded this case as a probable acute (idiopathic) interstitial pneumonia, or Hamman-Rich syndrome, responding dramatically to the corticosteroid pulse administration.
authors.affiliation: Department of Laboratory Medicine, Gunma University Faculty of Medicine, Maebashi, Japan. kjtamama@akagi.sb.gunma-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Tamama
authors.forename: T
authors.initials: T
authors.lastname: Yamato
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Sakahira
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: N
authors.initials: N
authors.lastname: Ishiyama
authors.forename: T
authors.initials: T
authors.lastname: Kanda
authors.forename: I
authors.initials: I
authors.lastname: Kobayashi
mesh_terms: D000208:Acute Disease; D000328:Adult; D003402:Creatine Kinase / Q000097:blood; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D011859:Radiography; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; C050574:6-methylprednisone; D003402:Creatine Kinase; D011241:Prednisone