title: [Normal polymorphism of the (CTG)n repeat in the myotonin protein kinase (DM) gene on chromosome 19q13.3 in Western European populations].
abstract: Polymorphism of a highly polymorphic CTG repeat in the 3'-untranslated region of the myotonin protein kinase gene was analyzed in healthy people from several Eastern European populations (Russians, Moldovans, Belarussians, Komis, Chuvashes, Udmurts, Bashkirs, Tatars, Maris, and Mordovians). In total, 26 alleles of the CTG repeat were found, the repeat number ranging from 5 to 33 (alleles with six and seven repeats were not detected). The heterozygosity of individual populations varied from 61 to 91%. In the total sample combining all populations, the observed and expected heterozygosities did not differ (fixation index -0.0022) suggesting selective neutrality of the normal polymorphism of the CTG repeat in the myotonin protein kinase gene.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia. slomin@img.ras.ru
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: S N
authors.initials: SN
authors.lastname: Popova
authors.forename: M I
authors.initials: MI
authors.lastname: Shadrina
authors.forename: M A
authors.initials: MA
authors.lastname: Pomazanova
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Lomova
authors.forename: R I
authors.initials: RI
authors.lastname: Fatkhlislamova
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
authors.forename: I A
authors.initials: IA
authors.lastname: Guseva
authors.forename: Sh
authors.initials: Sh
authors.lastname: Erdes
authors.forename: A I
authors.initials: AI
authors.lastname: Mikulich
authors.forename: V A
authors.initials: VA
authors.lastname: Spitsyn
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
mesh_terms: D000483:Alleles; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D005061:Europe, Eastern; D006579:Heterozygote; D065636:Myotonin-Protein Kinase; D011110:Polymorphism, Genetic; D011494:Protein Kinases / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases; D018911:Trinucleotide Repeats
chemical_list: C585517:DMPK protein, human; D011494:Protein Kinases; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases