title: A case of adult-onset Still's disease complicated by non-Hodgkin's lymphoma.
abstract: Left cervical lymphadenopathy developed in a 50-year-old male who had a history of adult-onset Still's disease for the preceding 18 months. Still's disease is characterized by rash, fever, and leukocytosis. Lymphadenopathy has been reported in about 60% of the patients, and most histopathologic studies have shown non-specific reactive hyperplasia. However, in this case, an open biopsy of the cervical node revealed a histology of diffuse large B-cell lymphoma. The B-cell malignant lymphoma that developed may have resulted from a sequential progression of a previous stage of benign lymphoproliferative lesion. Our case suggests that the pathophysiology of adult-onset Still's disease involves the stimulation of lymphoid systems to the point of progression towards lymphoma. Malignant lymphoma should be added to the list of life-threatening complications which, although rare, are associated with this disease.
authors.affiliation: 3rd Department of Internal Medicine, Kinki University, School of Medicine, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sono
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Miyazato
authors.forename: M
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Hamada
authors.forename: Y
authors.initials: Y
authors.lastname: Tatsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Funauchi
authors.forename: A
authors.initials: A
authors.lastname: Kanamaru
mesh_terms: D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016706:Still's Disease, Adult-Onset / Q000150:complications* / Q000503:physiopathology