Cell polarity: Scaffold proteins par excellence.
Par proteins are involved in determining cellular asymmetry. Recent studies have identified one of these proteins, Par6, as a key regulator of cell polarity and transformation via its interactions with small GTPases and atypical forms of protein kinase C.
Brazil
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DP
Friedrich Miescher Institute, Basel, Switzerland. brazild@fmi.ch
Hemmings
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BA
D000818:Animals; D016764:Cell Polarity; D015801:Helminth Proteins / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism*
D015801:Helminth Proteins; D011493:Protein Kinase C; D020764:cdc42 GTP-Binding Protein