Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma.
Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged animal lifespan by 40-60% in comparison with the control. The correlation coefficient between the tumor size and antibody titer after injection of mucin was -0.4 for IgM and -0.6 for IgG. Titration of IgG may be used for monitoring of the efficiency of specific immunotherapy.
Amandzholov
B S
BS
N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences.
Sitdikova
S M
SM
Lebedin
Y S
YS
Chukanov
S V
SV
Toptygin
A Y
AY
Manzyuk
L V
LV
Donenko
F V
FV
D000818:Animals; D018394:CA-125 Antigen / Q000276:immunology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D008808:Mice, Inbred CBA; D009077:Mucins / Q000276:immunology* / Q000627:therapeutic use; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000628:therapy*
D018394:CA-125 Antigen; D009077:Mucins