The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells.
Taraboletti
G
G
Institute of Pharmacological Sciences, University of Siena, Siena, Italy.
Morbidelli
L
L
Donnini
S
S
Parenti
A
A
Granger
H J
HJ
Giavazzi
R
R
Ziche
M
M
D000818:Animals; D004730:Endothelium, Vascular / Q000201:enzymology* / Q000378:metabolism / Q000502:physiology; D016222:Fibroblast Growth Factor 2 / Q000037:antagonists & inhibitors; D018093:Gelatinases / Q000378:metabolism*; D006493:Heparin / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D008970:Molecular Weight; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010446:Peptide Fragments / Q000502:physiology; D011817:Rabbits; D019700:Thrombospondin 1 / Q000502:physiology*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000096:biosynthesis* / Q000378:metabolism
D010446:Peptide Fragments; D019700:Thrombospondin 1; D016222:Fibroblast Growth Factor 2; D019716:Tissue Inhibitor of Metalloproteinase-2; D006493:Heparin; D018093:Gelatinases; D020778:Matrix Metalloproteinase 2