Spasmolytic constituents from Eucalyptus camaldulensis var. obtusa leaves.
Phytochemical studies on the leaves of Eucalyptus camaldulensis var. obtusa have resulted in the isolation of a new triterpenoid camaldulin (3beta-formyloxyurs-11-en-28,13beta-olide) (1) along with ursolic acid lactone acetate (2), ursolic acid lactone (3), betulinic acid (4), and beta-sitosterol 3-O-beta-D-glucopyranoside (5). The structures were assigned on the basis of 1D and 2D NMR studies. Compounds 1-3 were tested for spasmolytic activity and were found to possess calcium antagonist activity.
Begum
S
S
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. sabira@khi.comsats.net.pk
Farhat
F
F
Sultana
I
I
Siddiqui
B S
BS
Shaheen
F
F
Gilani
A H
AH
D002121:Calcium Channel Blockers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005052:Eucalyptus / Q000737:chemistry*; D010276:Parasympatholytics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal; D013057:Spectrum Analysis
D002121:Calcium Channel Blockers; D010276:Parasympatholytics