title: Multifocal eosinophilic granuloma of the jaw: long-term follow-up of a novel intraosseous corticoid treatment for recalcitrant lesions.
abstract: Eosinophilic granuloma of the jaws is a rather benign and localized form of Langerhans' cell histiocytosis. Treatment is usually required in larger lesions that cause local pain and swelling and pose the risk of spontaneous fractures. There are several accepted forms of treatment, which include surgery, radiation therapy, systemic and local therapy with corticoids, and systemic chemotherapy. No studies exist that compare the effectiveness of these treatment modalities. We report a novel therapeutic regimen that uses repeated intraosseous injections of triamcinolone-1 16 alpha 21-diacetat, a synthetic corticoid, which led to a rapid, complete, and durable treatment. The patient had a multilocal eosinophilic granuloma of the mandible in which radiation therapy, systemic corticoid therapy, and systemic chemotherapy had failed.
authors.affiliation: The Department of Oral and Maxillofacial Surgery, Donauspital Wien, University of Vienna, Austria.
authors.forename: I M
authors.initials: IM
authors.lastname: Watzke
authors.forename: W
authors.initials: W
authors.lastname: Millesi
authors.forename: C
authors.initials: C
authors.lastname: Kermer
authors.forename: H
authors.initials: H
authors.lastname: Gisslinger
mesh_terms: D000328:Adult; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D004803:Eosinophilic Granuloma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008297:Male; D008334:Mandible; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011859:Radiography; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D014221:Triamcinolone; C030262:triamcinolone diacetate