title: A case of pyoderma gangrenosum on the stump of an amputated right leg.
abstract: We present here a case of pyoderma gangrenosum (PG) on the stump of an amputated leg. The patient was a 69-year-old woman who had both of her legs amputated due to acute arterial occlusion. An ulcer first appeared nine years later, after which point it continued to fluctuate in size. Complications included regional blood flow disorder at the amputated stump, diabetes, and secondary infection. Despite various therapies, the ulcer exacerbated, and hypoproteinemia, increased CRP, and fever were confirmed. The patient was diagnosed as having PG based on her clinical symptoms and because the ulcer did not respond to various therapies. The ulcer improved significantly in response to administration of 40 mg/day of prednisolone, and complete epithelialization was later achieved. Given the presence of multiple complications, it was extremely difficult to confirm PG. Therefore, it is important for physicians to consider PG as one of the causes of intractable ulcers.
authors.affiliation: Department of Dermatology, Tokyo Medical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Umezawa
authors.forename: S
authors.initials: S
authors.lastname: Oyake
authors.forename: T
authors.initials: T
authors.lastname: Oh-i
authors.forename: T
authors.initials: T
authors.lastname: Nagae
authors.forename: S
authors.initials: S
authors.lastname: Ishimaru
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D000672:Amputation Stumps / Q000473:pathology*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000150:complications / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy; D017719:Diabetic Foot / Q000150:complications / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D016106:Methicillin Resistance; D011239:Prednisolone / Q000627:therapeutic use; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000302:isolation & purification
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone