title: Clinical outcome of pediatric patients on peritoneal dialysis under adequacy control.
abstract: Clinical outcome under adequacy control was studied in 10 pediatric patients under 5 years and 11 patients over 5 years of age on continuous peritoneal dialysis (PD). Outcome was compared between the age groups and with our previous results in patients under 5 years of age. Peritoneal equilibration test and 24-h dialysate collection were performed. Laboratory data, clinical status, and diet were recorded. PD prescription was adjusted for these parameters. The mean weekly urea Kt/V was similar and stable in the two age groups (3.1+/-0.6 vs. 3.2+/-0.4 at baseline). The mean weekly creatinine clearance (C(Cr)) was at baseline significantly lower in the younger age group (58.7+/-11.9 vs. 78.0+/-14.9 l/week per 1.73 m2, P=0.004), but later similar. Urea Kt/V and C(Cr) correlated significantly. Hematological and biochemical parameters were stable, and catch-up growth was observed in 62% of the patients during 9 months of follow-up. The outcome for children under and over 5 years of age did not differ significantly. The clinical outcome in patients under 5 years of age improved under adequacy control, when compared with our previous results in patients of the same age. This suggests a positive effect of adequacy control on clinical outcome.
authors.affiliation: Department of Pediatric Nephrology and Transplantation, Hospital for Children and Adolescents, University of Helsinki, Finland. Tuula.Holtta@huch.fi
authors.forename: T
authors.initials: T
authors.lastname: Hölttä
authors.forename: K
authors.initials: K
authors.lastname: Rönnholm
authors.forename: H
authors.initials: H
authors.lastname: Jalanko
authors.forename: C
authors.initials: C
authors.lastname: Holmberg
mesh_terms: D000293:Adolescent; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002404:Catheterization / Q000009:adverse effects; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D002675:Child, Preschool; D006128:Growth; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology; D007223:Infant; D007239:Infections / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D010530:Peritoneal Dialysis / Q000009:adverse effects / Q000295:instrumentation; D010538:Peritonitis / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents