title: [Comparison of platelet activation and procoagulant activity of blood cells in healthy pregnant women and EPH-gestosis patients].
abstract: OBJECTIVE
  EPH-gestosis is one of the most frequent complications of pregnancy, labour and puerperium. Despite its unknown ethiology, many authors suggest a vital role played by platelets as an ethiopathogenic factor. The aim of this study was to observe the level of platelets activation in EPH-gestosis subjects.
  
  
  METHODS
  Platelets activation level has been observed in 16 EPH-gestosis third semester pregnant women and 14 normotensive third semester pregnant controls. Platelets double-labeled with monoclonal antibodies and a flow cytometer have been used in assessment of platelet activation level. Anti-P-selectin (GMP 140- Granule Membrane Protein) has been used as a marker of the platelet released reaction. Fibrinogen, D-dimers, antithrombin and thrombin-antithrombin complexes levels have been analyzed.
  
  
  RESULTS
  An increased platelet activation (p < 0.005) as well as the increased level of thrombin-antithrombin (p < 0.005) in pregnant EPH-gestosis women comparing to control group, has been observed in the study.
  
  
  CONCLUSIONS
  A state of hypercoaguability and enhanced platelet activation in pregnant EPH-gestosis women have been observed.
authors.affiliation: Kliniki Chirurgii Ginekologicznej, Instytut-Centrum Zdrowia Matki Polki, Lódź.
authors.forename: D
authors.initials: D
authors.lastname: Kolasa
authors.forename: A
authors.initials: A
authors.lastname: Malinowski
authors.forename: Z
authors.initials: Z
authors.lastname: Baj
authors.forename: D
authors.initials: D
authors.lastname: Owczarek
authors.forename: A
authors.initials: A
authors.lastname: Szpakowski
authors.forename: M A
authors.initials: MA
authors.lastname: Dyński
authors.forename: M
authors.initials: M
authors.lastname: Szpakowski
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology; D005260:Female; D005340:Fibrinogen / Q000502:physiology*; D006801:Humans; D015539:Platelet Activation / Q000502:physiology*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013917:Thrombin / Q000502:physiology*
chemical_list: D000911:Antibodies, Monoclonal; D005340:Fibrinogen; D013917:Thrombin