title: [Dose intensity of chemotherapy in small-cell lung carcinoma. Review of comparative studies].
abstract: Chemotherapy improves survival and achieves an impressive response rate, and, eventually, a percentage of long-term survivors in small-cell lung cancer. A possible way to a further improvement of these therapeutic outcomes is increasing chemotherapy dose-intensity. However, randomised comparative trials only show a slight improvement of results, with small clinical relevance. Prophylactic use of colony-stimulating factors decrease the incidence of neutropenia and neutropenic fever in comparative studies when an exceedingly myelotoxic chemotherapy regimen is used. And they also permit a little increase in chemotherapy dose-intensity without significant antineoplastic effect and almost no impact in overall survival. Nowadays, the administration of higher doses of chemotherapy in small-cell lung cancer still remains investigational in oncology.
authors.affiliation: Servicio de Oncología, Hospital Universitario, Valladolid.
authors.forename: A
authors.initials: A
authors.lastname: Sanz Rubiales
authors.forename: M L
authors.initials: ML
authors.lastname: del Valle Rivero
authors.forename: M
authors.initials: M
authors.lastname: Garavís Vicente
authors.forename: P
authors.initials: P
authors.lastname: Rey Castro
authors.forename: F
authors.initials: F
authors.lastname: López-Lara Martín
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016026:Bone Marrow Transplantation; D018288:Carcinoma, Small Cell / Q000188:drug therapy*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents