G-protein beta(3)-subunit C825T genotype and nephropathy in diabetes mellitus.
BACKGROUND
Recent studies have identified a novel polymorphism (C825T) of the gene encoding the beta(3) subunit of heterotrimeric G proteins (G:beta(3)) which is associated with enhanced activation of G-proteins and appears to be more common in hypertensive patients and possibly contributes to decreased kidney allograft survival.


METHODS
In the present study we examined the relationship between this genetic variant, type 1 and type 2 diabetes and renal complications of diabetes in 1008 Caucasian patients recruited from an outpatient diabetes clinic and four dialysis centres. We also studied 1940 healthy controls.


RESULTS
After multivariate adjustment and in univariate statistics, the G:beta(3) 825TT genotype was not associated with a significantly enhanced risk of diabetes or renal complications.


CONCLUSIONS
These findings indicate that the G:beta(3) 825T allele apparently does not contribute to the development of diabetes or associated renal complications in patients with type 1 or type 2 diabetes mellitus.
Beige
J
J
Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitätsklinikum Benjamin Franklin, Free University of Berlin, Berlin, Germany.
Ringel
J
J
Distler
A
A
Sharma
A M
AM
D000328:Adult; D000368:Aged; D000483:Alleles; D003922:Diabetes Mellitus, Type 1; D003924:Diabetes Mellitus, Type 2; D003928:Diabetic Nephropathies / Q000235:genetics*; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012016:Reference Values
D019204:GTP-Binding Proteins