Notch signaling: Fringe really is a glycosyltransferase.
Fringe modifies the ligand-selectivity of Notch in ways that are crucial for a number of Notch's developmental functions. Recent results have confirmed the suspicion that Fringe is a glycosyltransferase that works in the Golgi complex by modifying Notch's glycosylation state.
Blair
S S
SS
Department of Zoology, University of Wisconsin, Madison 53706, USA. ssblair@facstaff.wisc.edu
D000818:Animals; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000254:growth & development* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D016695:Glycosyltransferases / Q000378:metabolism*; D019476:Insect Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D017351:N-Acetylglucosaminyltransferases; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology
D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; D016695:Glycosyltransferases; D017351:N-Acetylglucosaminyltransferases; C090576:fng protein, Drosophila