Approaches to the fully functionalized DEF ring system of ristocetin A via highly selective ruthenium-promoted S(N)Ar reaction.
Ruthenium-promoted intramolecular S(N)Ar reaction has allowed the construction of the fully functionalized 16-membered DEF macrocycle 4 of ristocetin A that incorporates the required arylglycine and arylserine residues as the F and E ring, respectively.
Pearson
A J
AJ
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA. ajp4@po.cwru.edu
Heo
J N
JN
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D012310:Ristocetin / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry*; D017334:Teicoplanin / Q000138:chemical synthesis; D014640:Vancomycin / Q000138:chemical synthesis
D000900:Anti-Bacterial Agents; D012310:Ristocetin; C016719:ristocetin A; D017334:Teicoplanin; D014640:Vancomycin; D012428:Ruthenium