Synthesis and antibacterial activity of new cephalosporines containing a pyrrole ring in the N-acyl chain.
Nine new cephalosporines containing a pyrrole ring in the N-acyl chain have been synthesized by the N-acylation of 7-ACA or of its 3-analogues via the acid chlorides of substituted 2-pyrrole-carboxylic, -acetic or -propionic acids. H1 NMR and IR data confirming the structure are presented. Preliminary microbiological tests in vitro show significant antibacterial activity, compared with that of cefalexin. Some common structure-activity relationships have been observed.
Bijev
A
A
University of Chemical Technology and Metallurgy, Sofia, Bulgaria. a.bijev@uctm.edu
Radev
I
I
Borisova
Y
Y
D000215:Acylation; D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013211:Staphylococcus aureus / Q000187:drug effects
D002511:Cephalosporins