Prevalence of CagA and VacA antibodies in children with Helicobacter pylori-associated peptic ulcer compared to prevalence in pediatric patients with active or nonactive chronic gastritis.
VacA and CagA serological responses were detected in pediatric patients: 44 and 56%, respectively, in peptic ulcer (PU) patients, 33.3 and 44.4% in active chronic gastritis (ACG) patients, and 23.2 and 39.2% in non-ACG patients. Higher seroprevalence to CagA+VacA and to CagA+VacA+35-kDa antigen was found among PU patients. However, a low level of sensitivity and specificity was found for indirect detection of PU patients.
Alarcón
T
T
Department of Microbiology, Hospital Universitario de la Princesa, Madrid, Spain. talarcon@helicobacterspain.com
Martínez
M J
MJ
Urruzuno
P
P
Cilleruelo
M L
ML
Madruga
D
D
Sebastian
M
M
Domingo
D
D
Sanz
J C
JC
López-Brea
M
M
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D015153:Blotting, Western / Q000379:methods; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016036:Seroepidemiologic Studies; D013030:Spain / Q000453:epidemiology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori