title: Exposure of Russian phenoxy herbicide producers to dioxins.
abstract: Russian workers who manufactured phenoxy herbicides and related compounds in the 1960s in the city of Ufa, Bashkortostan, a republic of the former Soviet Union, were studied for exposure to polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans. Sixty whole blood samples were drawn in September 1992 and analyzed by gas chromatography-mass spectrometry. Thirty-four workers who manufactured the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) had median blood lipid 2,3,7,8-tetrachlorodibenzo-p-diozin (TCDD) concentrations of 166 ng per kg (parts per trillion) and 1,2,3,7,8-pentachloro-p-dioxin (PnCDD) levels of 52 parts per trillion with several TCDD values greater than 500 ng/kg. These 1992 values are 10 to 30 times greater than contemporary normal or background blood levels from the Baskortostan region of Russia and were at least 10-fold higher 25 years earlier in the late 1960s. Six workers who produced the herbicide 2,4-dichlorophenoxyacetic acid also had elevated levels in 1992, with 1,2,3,7,8-PnCDD blood lipid levels higher than 2,3,7,8-TCDD. Even children of some of the workers and factory administrative personnel had blood levels of TCDD higher than most general population groups from other parts of Russia or from other countries. The patterns of the PCDDs and dibenzofurans (as defined by the specific congeners and their relative amounts) were distinctive for the type of chemical produced, with notable contributions to the TCDD toxic equivalents from the 2,3,7,8-TCDD and 1,2,3,7,8-PnCDD congeners. No correlation was found between chloracne status in 1965 to 1967 and TCDD or toxic equivalent blood lipid concentrations in 1992. These Russian phenoxy herbicide and related chemical producers have some of the highest occupational exposure to dioxins of any cohort studied to date and seem to be unique with respect to the presence of appreciable amounts of 1,2,3,7,8-PnCDD.
authors.affiliation: Health Canada, Health Protection Branch, Ottawa, Canada. jake_ryan@hc-sc.gc.ca
authors.forename: J J
authors.initials: JJ
authors.lastname: Ryan
authors.forename: A
authors.initials: A
authors.lastname: Schecter
mesh_terms: D000293:Adolescent; D000328:Adult; D004147:Dioxins / Q000097:blood*; D004785:Environmental Pollutants / Q000097:blood*; D005190:Family; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006540:Herbicides; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000097:blood; D012426:Russia; D017678:Sex Distribution
chemical_list: D004147:Dioxins; D004785:Environmental Pollutants; D006540:Herbicides; D000072317:Polychlorinated Dibenzodioxins