An integrin chicken and egg problem: which comes first, the extracellular matrix or the cytoskeleton?
Integrins have the ability to organise macromolecular structures both inside and outside the cell. Analysis of integrin function in the developing embryos of worms and flies suggests that, although the extracellular matrix directs integrins to organise intracellular proteins, the cytoskeleton may have the first word.
Brown
N H
NH
Wellcome/CRC Institute and Department of Anatomy, University of Cambridge, Tennis Court Rd, CB2 1QR, Cambridge, UK. nb117@mole.bio.cam.ac.uk
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D004330:Drosophila / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D016023:Integrins / Q000502:physiology*
D016023:Integrins