Sorting out the multiple roles of Fas ligand.
Fas ligand can both be used by the immune system to initiate cell death, and be used by non-lymphoid cells to evade death. Recent work has shown that Fas ligand is differentially sorted in different cell types. Here we present the viewpoint that the differential sorting plays an important part in determining the role of Fas ligand in different cells.
Bossi
G
G
Sir William Dunn School of Pathology, Oxford, UK.
Stinchcombe
J C
JC
Page
L J
LJ
Griffiths
G M
GM
D000818:Animals; D015704:CD4 Antigens / Q000276:immunology; D053222:Fas Ligand Protein; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D008247:Lysosomes / Q000276:immunology / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology; D021381:Protein Transport / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure
D015704:CD4 Antigens; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins