Application of acoustic emission to the monitoring and end point determination of a high shear granulation process.
The application of a novel monitoring technique, based on the use of acoustic emissions, is reported for a model high shear granulation process. It has been demonstrated that this technique is capable of monitoring changes in physical properties of powder material during granulation (particle size, flow properties and compression properties). The technique is non-invasive, sensitive and relatively inexpensive.
Whitaker
M
M
Pharmaceutical Development, Glaxo Wellcome Research and Development, Park Road, Ware, Hertfordshire, SG12 0DP, UK. mw2541@glaxowellcome.co.uk
Baker
G R
GR
Westrup
J
J
Goulding
P A
PA
Rudd
D R
DR
Belchamber
R M
RM
Collins
M P
MP
D000162:Acoustics; D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D010316:Particle Size; D011208:Powders / Q000138:chemical synthesis*; D013018:Sound Spectrography / Q000379:methods; D013607:Tablets / Q000138:chemical synthesis*
D011208:Powders; D013607:Tablets