Evaluation of solid-state forms present in tablets by Raman spectroscopy.
In this study the potential of Fourier transform (FT)-Raman spectroscopy as a method to probe the solid-state form of active substances present in tablets and capsules is explored. Raman spectra were obtained from intact tablets and capsules containing enalapril maleate, prednisolone, form I and form II polymorphs of ranitidine, anhydrous and monohydrate theophylline, and warfarin sodium clathrate. Spectra were also collected from the corresponding drug substances. These studies show that it is possible to detect the active ingredients in the intact dosage form, even where the substance comprises <1% of the total mass of the tablet. Moreover, it is shown that, in some cases, Raman spectroscopy can also be used to investigate the solid-state form of a drug present in the dosage form and even to determine if a mixture of forms are present.
Taylor
L S
LS
Solid State Analysis, Pharmaceutical and Analytical R&D, AstraZeneca R&D Mölndal, S-431 83 Mölndal, Sweden. lynne.taylor@astrazeneca.com
Langkilde
F W
FW
D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D000897:Anti-Ulcer Agents / Q000737:chemistry*; D000925:Anticoagulants / Q000737:chemistry*; D000959:Antihypertensive Agents / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000737:chemistry*; D004656:Enalapril / Q000737:chemistry; D005583:Fourier Analysis; D011239:Prednisolone / Q000737:chemistry; D011899:Ranitidine / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013607:Tablets; D013806:Theophylline / Q000737:chemistry; D014859:Warfarin / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D000897:Anti-Ulcer Agents; D000925:Anticoagulants; D000959:Antihypertensive Agents; D001993:Bronchodilator Agents; D013607:Tablets; D014859:Warfarin; D004656:Enalapril; D011899:Ranitidine; D011239:Prednisolone; D013806:Theophylline