title: Normal and leukaemic haematopoiesis in bone marrow and peripheral blood of patients with chronic myeloid leukaemia.
abstract: In the majority of newly diagnosed patients with chronic myeloid leukaemia (CML), the bone marrow contains consistent numbers of normal Ph-negative surrogate stem cells (LTC-IC) which seem to decline rapidly with time. This is confirmed by mobilization studies showing that early after diagnosis is the optimal time to collect Ph-negative progenitor to be utilized for restoring Ph-negative haematopoiesis. In the marrow of the majority of CML patients at diagnosis Ph-positive LTC-IC are found at a lower frequency than Ph-negative LTC-IC and, unexpectedly, they do not show a tendency to increase with time as long as patients remain in chronic phase. Therefore, the decline of normal haematopoiesis does not seem related to a parallel increase in Ph-positive stem cells.
authors.affiliation: Dipartimento di Ematologia, Divisione Ematologia II, Ospedale San Martino, Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Frassoni
authors.forename: M
authors.initials: M
authors.lastname: Podestà
authors.forename: G
authors.initials: G
authors.lastname: Piaggio
mesh_terms: D001781:Blood Component Removal / Q000379:methods / Q000592:standards; D001853:Bone Marrow / Q000473:pathology* / Q000503:physiopathology; D006410:Hematopoiesis / Q000235:genetics; D006411:Hematopoiesis, Extramedullary / Q000235:genetics; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods / Q000592:standards; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*