title: Identification and targeting policies for computer-controlled infusion pumps.
abstract: In this article a series of useful techniques is presented to improve the adaptation capabilities of computer-controlled infusion pumps: an identification algorithm for the time constant of the effect compartment, a smoothing technique for estimation based on noisy data, and an infusion policy to target any effect site concentration with no overshoot.
authors.affiliation: ETH Zürich, Institut für Automatik, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Gentilini
authors.forename: C W
authors.initials: CW
authors.lastname: Frei
authors.forename: A H
authors.initials: AH
authors.lastname: Glattfelder
authors.forename: M
authors.initials: M
authors.lastname: Morari
authors.forename: T W
authors.initials: TW
authors.lastname: Schnider
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D007260:Infusion Pumps; D010599:Pharmacokinetics; D013813:Therapy, Computer-Assisted / Q000379:methods*