Bone mineral density, vitamin D and anticonvulsant therapy.
The aim of this study was to assess bone mineral density and vitamin D metabolism in patients on chronic anticonvulsant therapy.


METHODS
Sixty-nine men, outpatients on chronic anticonvulsant therapy, who had been treated for at least 5 years, were studied, comparing them to thirty healthy controls. Bone mineral density was measured as well as serum levels of calcium, ionized calcium, alkaline phosphatase, PTH, 25-hydroxycholecalciferol and 1, 25-dihydroxycholecalciferol.


RESULTS
No differences in bone mineral density, serum levels of vitamin D and intact-PTH were observed between patients and controls. Bone mineral density was not associated with chronic anticonvulsant therapy.


CONCLUSIONS
Those adult patients who were on chronic anticonvulsant therapy and who lived in low latitude regions had normal bone mineral density as well as vitamin D serum levels.
Filardi
S
S
Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Brazil.
Guerreiro
C A
CA
Magna
L A
LA
Marques Neto
J F
JF
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D015519:Bone Density; D016022:Case-Control Studies; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014807:Vitamin D / Q000097:blood*
D000927:Anticonvulsants; D014807:Vitamin D; D010672:Phenytoin; D010634:Phenobarbital