The role of chromosomal RNAs in marking the X for dosage compensation.
Both flies and mammals remodel the architecture of the X chromosome to achieve dosage compensation. A novel class of noncoding RNAs that paint entire chromosomes are centrally involved in this process. The genes encoding these unusual RNAs are themselves located on the X, and are key sites that target the X for dosage compensation.
Kelley
R L
RL
Baylor College of Medicinem, Department of Molecular and Cellular Biology, One Baylor Plaza, Mail Stop BCM235, Houston, Texas 77030, USA. rkelley@bcm.tmc.edu
Kuroda
M I
MI
D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins; D004303:Dosage Compensation, Genetic; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D012313:RNA / Q000235:genetics / Q000502:physiology*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D016601:RNA-Binding Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D014960:X Chromosome / Q000235:genetics*
D002843:Chromatin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; C092595:Pabp2 protein, Drosophila; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C077885:XIST non-coding RNA; C082132:msl-1 protein, Drosophila; C094166:msl-2 protein, Drosophila; D012313:RNA