title: Immunology. Therapeutic manipulation of gut flora.
abstract: In developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders (Steidler et al.).
authors.affiliation: Department of Medicine, Cork University Hospital, Cork, Ireland. fshanahan@ucc.ie
authors.forename: F
authors.initials: F
authors.lastname: Shanahan
mesh_terms: D000818:Animals; D005818:Genetic Engineering; D006801:Humans; D018928:Immunity, Mucosal; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000628:therapy*; D016753:Interleukin-10 / Q000008:administration & dosage / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology / Q000382:microbiology; D007422:Intestines / Q000276:immunology / Q000382:microbiology*; D013294:Lactococcus lactis / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D019936:Probiotics / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D011994:Recombinant Proteins; D016753:Interleukin-10