Tachyarrhythmias in a surgical intensive care unit: a case-controlled epidemiologic study.
OBJECTIVE
Incidence, types, and factors associated with new onset tachyarrhythmias (TA) in surgical intensive care patients.


METHODS
Pairwise-matched case-controlled study.


METHODS
Surgical intensive care unit (ICU) with nine intensive care beds.


METHODS
During a 1-year period, all TA patients (n = 89) were included in the study. Control patients (n = 82) without TA were matched according to age, sex, and surgical region.


METHODS
TA workup included: 12-lead ECG, arterial blood gas, serum electrolyte (K+, Mg2+), and serum CK/CKMB isoenzyme analysis. Pre-existing cardiovascular and pulmonary disease, cardiovascular risk factors, preoperative regular medication, and admission SAPS were recorded in all patients. A multiple organ dysfunction syndrome (MODS) score, the presence or absence of SIRS or sepsis, and hemodynamics (MAP and CVP) before onset of TA were evaluated in TA patients, while in control patients highest MODS-score, the presence or absence of SIRS or sepsis, mean hemodynamic and laboratory values calculated from highest and lowest readings during ICU stay were used for statistical comparison. Logistic regression analysis was performed to identify variables multivariately associated with TA.


RESULTS
Eighty-nine (14.8%) of 596 patients developed TA. Atrial fibrillation was most frequent (60.7%). Presence of SIRS or sepsis (adj. OR = 36.45; 95% CI: 11.5-115.5), high admission SAPS (adj. OR = 1.25/point; 95% CI: 1.08-1.44), high CVP (adj. OR = 1.27/mmHg; 95% CI: 1.09-1.48), and low arterial oxygen tension (adj. OR = 0.97/mmHg); 95% CI: 0.95-0.99) were found to be significant predictors for development of TA.


CONCLUSIONS
In surgical patients hypoxia, high cardiac filling pressures, a greater degree of physiologic derangement at admission, and the presence of SIRS and sepsis are independent risk factors for the development of TA.
Knotzer
H
H
Department of Anesthesia and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Austria.
Mayr
A
A
Ulmer
H
H
Lederer
W
W
Schobersberger
W
W
Mutz
N
N
Hasibeder
W
W
D000368:Aged; D000704:Analysis of Variance; D001317:Austria / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006439:Hemodynamics; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D016555:Matched-Pair Analysis; D009102:Multiple Organ Failure / Q000150:complications; D016017:Odds Ratio; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000150:complications; D013610:Tachycardia / Q000453:epidemiology* / Q000209:etiology