title: Occupational allergic airbone contact dermatitis and delayed bronchial asthma from epoxy resin revealed by bronchial provocation test.
abstract: Diglycidyl ether of bisphenol A (DGEBA) epoxy resins belong to the most common causes of occupational allergic contact dermatitis. DGEBA has on rare occasions caused occupational asthma. Here we present a patient who first developed occupational allergic contact dermatitis (ACD) caused by a single accidental exposure to DGEBA. Then, on continued occupational exposure to DGEBA, the patient developed occupational asthma from DGEBA, in addition to ACD. A bronchial provocation test with DGEBA caused a 36% drop in the peak expiratory flow, reflecting a delayed type of occupational asthma. This bronchial provocation test caused a strong dermatitis of the exposed skin of the face, in accordance with airborne ACD from DGEBA.
authors.affiliation: Section of Occupational Dermatology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN-00250 Helsinki, Finland. Lasse.Kanerva@occuphealth.fi
authors.forename: L
authors.initials: L
authors.lastname: Kanerva
authors.forename: T
authors.initials: T
authors.lastname: Estlander
authors.forename: H
authors.initials: H
authors.lastname: Keskinen
authors.forename: R
authors.initials: R
authors.lastname: Jolanki
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced* / Q000473:pathology; D001559:Benzhydryl Compounds; D001985:Bronchial Provocation Tests; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000473:pathology; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000473:pathology; D004852:Epoxy Compounds / Q000009:adverse effects; D004853:Epoxy Resins / Q000009:adverse effects*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D000098826:Bisphenol A Compounds
chemical_list: D000395:Air Pollutants, Occupational; D001559:Benzhydryl Compounds; D004852:Epoxy Compounds; D004853:Epoxy Resins; C019273:bisphenol A diglycidyl ether; D000098826:Bisphenol A Compounds