Three different anti-myelin antibodies in a case of demyelinating dysglobulinemic peripheral neuropathy.
We report the case of a patient with a severe, predominantly motor, demyelinating neuropathy associated with an IgM kappa biclonal gammopathy. Immunoblot studies showed IgM reactivity against MAG, and IgG reactivity against a peripheral nerve myelin-specific protein of approximately 35 kDa. Immunodetection by thin layer chromatography showed IgM reactivity towards GM1 and GD1b, as well as towards SGPG and SGLPG. This case illustrates the existence of overlapping syndromes among dysglobulinemic neuropathies, and points to an interaction of different autoantibodies in the pathogenesis of the nerve lesions.
Ellie
E
E
INSERM U394, Neurobiologie Integrative, Bordeaux, France.
Younes-Chennoufi
A B
AB
Couto
A
A
Vital
A
A
Hilmi
S
S
Demotes-Mainard
J
J
Baumann
N
N
Petry
K G
KG
D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000032:analysis*; D015152:Blotting, Northern; D001921:Brain / Q000276:immunology / Q000473:pathology; D002855:Chromatography, Thin Layer; D003711:Demyelinating Diseases / Q000276:immunology* / Q000473:pathology; D004591:Electrophoresis, Polyacrylamide Gel; D005677:G(M1) Ganglioside / Q000276:immunology; D006017:Glycolipids / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000276:immunology; D008297:Male; D009186:Myelin Sheath / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000473:pathology; D012584:Sciatic Nerve / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies; D006017:Glycolipids; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D018992:Myelin-Associated Glycoprotein; D005677:G(M1) Ganglioside