[Increased prevalence of APC-resistance (factor V Leiden mutation) in patients with postthrombotic syndrome].
OBJECTIVE
APC resistance (Factor V Leiden mutation) is the most often diagnosed hereditary thrombolytic defect. Data about the prevalence in patients with leg ulcers, especially postthrombosis, are limited of this defect.


METHODS
APC resistance was determined in 100 patients with venous leg ulcers. 53 patients had ulcers caused by postthrombotic syndrome and 47 patients ulcers associated with primary varicosities. A control group of 96 healthy volunteers was also studied.


RESULTS
19 of 53 patients (36%) with postthrombotic ulcers and 3 of 47 patients (6%) with varicosity-related ulcers had APC resistance. In the control group APC resistance was detected in 5 of 96 volunteers (5%).


CONCLUSIONS
APC resistance should be considered as a risk factor for the development of venous leg ulcers.
Gaber
Y
Y
Klinik für Dermatologie und Venerologie, Medizinische Universität zu Lübeck.
Siemens
H J
HJ
Schmeller
W
W
D020016:Activated Protein C Resistance / Q000150:complications* / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011186:Postphlebitic Syndrome / Q000150:complications / Q000209:etiology*
D005165:Factor V