title: Cancer of the gallbladder associated with pancreaticobiliary maljunction without bile duct dilatation in a european patient.
abstract: A rare case of pancreaticobiliary maljunction (PBM) without dilatation of the biliary tract (DBT) associated with gallbladder carcinoma is described herein. A 62-year-old European woman with a long history of right upper abdominal pain was diagnosed as having PBM without DBT by endoscopic retrograde cholangiopancreatography and other examinations. Excision of the gallbladder and biliary duct with a Roux-en-Y hepaticojejunostomy was performed, and subsequent pathological examination of the surgical specimen showed a well differentiated adenocarcinoma of the gallbladder. She had no clinical symptoms for 58 months postoperatively. PBM allows reflux of pancreatic juice into the biliary tract. Recent findings support the idea that epithelial hyperplasia plays an important role in gallbladder carcinogenesis with PBM, and also support the concept that gene mutations are involved in the carcinogenesis of biliary epithelium in patients with PBM. For these reasons, we advocate that resection of the extrahepatic biliary tract in PBM patients without bile duct dilatation, rather than cholecystectomy alone, is the treatment of choice for preventing bile duct carcinoma.
authors.affiliation: Department of Digestive Surgery, Angers University Hospital, 4 rue Larrey, 49000, Angers, France.
authors.forename: J J
authors.initials: JJ
authors.lastname: Tuech
authors.forename: P
authors.initials: P
authors.lastname: Pessaux
authors.forename: C
authors.initials: C
authors.lastname: Aube
authors.forename: N
authors.initials: N
authors.lastname: Regenet
authors.forename: C
authors.initials: C
authors.lastname: Cervi
authors.forename: R
authors.initials: R
authors.lastname: Bergamaschi
authors.forename: J P
authors.initials: JP
authors.lastname: Arnaud
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000601:surgery*; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002763:Cholecystectomy / Q000379:methods; D003135:Common Bile Duct / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007582:Jejunostomy; D008099:Liver / Q000601:surgery; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000601:surgery; D016896:Treatment Outcome