Continuous propofol administration for suxamethonium-induced postoperative myalgia.
The effect of continuous propofol administration on creatine kinase and suxamethonium-induced postoperative myalgia was evaluated in 50 patients randomised into two groups of 25 patients each. Induction of anaesthesia was identical in all patients. Anaesthesia was maintained with 66% nitrous oxide in oxygen supplemented by either isoflurane 1% or continuous propofol. Creatine kinase was measured before and after operation. Myalgia was evaluated postoperatively by a blinded observer. The median level of myalgia was reduced significantly in the continuous propofol group (p = 0.011). The median creatine kinase value increased significantly in the isoflurane group (from 90 to 160 IU, p = 0.001).
Manataki
A D
AD
Department of Anaesthesiology, G. Hatzikosta General Hospital, Ioannina, Greece.
Arnaoutoglou
H M
HM
Tefa
L K
LK
Glatzounis
G K
GK
Papadopoulos
G S
GS
D000328:Adult; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic; D003402:Creatine Kinase / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects*; D010146:Pain / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control; D010149:Postoperative Pain / Q000139:chemically induced / Q000517:prevention & control; D015742:Propofol / Q000627:therapeutic use*; D013390:Succinylcholine / Q000009:adverse effects*
D018686:Anesthetics, Intravenous; D009467:Neuromuscular Depolarizing Agents; D003402:Creatine Kinase; D013390:Succinylcholine; D015742:Propofol