title: Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide.
abstract: Lipopolyamines, with high affinity for calf thymus DNA in an ethidium bromide displacement assay, bind with high affinity to bacterial lipopolysaccharide and neutralise in vitro endotoxic activity as determined by Griess nitric oxide and TNF-alpha ELISA assays.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, UK. prsisb@bath.ac.uk
authors.forename: I S
authors.initials: IS
authors.lastname: Blagbrough
authors.forename: A J
authors.initials: AJ
authors.lastname: Geall
authors.forename: S A
authors.initials: SA
authors.lastname: David
mesh_terms: D000818:Animals; D002460:Cell Line; D008070:Lipopolysaccharides / Q000378:metabolism*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D011073:Polyamines / Q000378:metabolism*; D013096:Spermine / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D008070:Lipopolysaccharides; D011073:Polyamines; D014409:Tumor Necrosis Factor-alpha; D013096:Spermine; D009569:Nitric Oxide