title: Proliferative histiocytic disorders of canine skin.
abstract: Proliferative histiocytic disorders of canine skin present a clinical spectrum from the innocuous self-limiting solitary dermal lesion of cutaneous histiocytoma, through the recurrent deep dermal nodules of cutaneous histiocytosis to the generally fatal condition of Bernese Mountain Dogs termed systemic histiocytosis, in which visceral involvement is commonly encountered. Immunocytochemical characterization of the constituent histiocytic cells and accompanying lymphoid infiltrate using canine species specific reagents has elucidated considerably the mechanism by which these conditions exhibit their various biologic behaviours.
authors.affiliation: Department of Veterinary Science, Veterinary Clinical Centre, Werribee, Victoria, Australia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Middleton
mesh_terms: D000818:Animals; D002455:Cell Division; D003937:Diagnosis, Differential; D004285:Dogs; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000473:pathology*; D015614:Histiocytosis / Q000175:diagnosis / Q000473:pathology*; D007150:Immunohistochemistry; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*