BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.
Babu
Y S
YS
BioCryst Pharmaceuticals, Inc., 2190 Parkway Lake Drive, Birmingham, Alabama 35244, USA. babu@biocryst.com
Chand
P
P
Bantia
S
S
Kotian
P
P
Dehghani
A
A
El-Kattan
Y
Y
Lin
T H
TH
Hutchison
T L
TL
Elliott
A J
AJ
Parker
C D
CD
Ananth
S L
SL
Horn
L L
LL
Laver
G W
GW
Montgomery
J A
JA
D000146:Acids, Carbocyclic; D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006146:Guanidines; D009980:Influenza A virus / Q000201:enzymology*; D009981:Influenza B virus / Q000201:enzymology*; D051379:Mice; D008958:Models, Molecular; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D011485:Protein Binding; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D006146:Guanidines; D009439:Neuraminidase; C414210:peramivir