[The cellular and humoral mechanisms of the radioprotective action of prodigiozan and indometofen on long-term mouse bone marrow cultures].
Effects of prodigiosan and indometophen on the contents and proliferative activity of CFU and CFU-GM as well as GM-CSF prior to radiation were studied in long-term cultures of murine bone marrow. 24 hours and 5 days after administration of prodigiosan and indometophen, respectively, the long-term cultures were exposed to ionising radiation in a dose 2.0 Gy. Then, postradiation restoration of early hemopoietic cells-precursors was assessed. In unradiated cultures 24 hours after prodigiosan administration content of CFU, CFU-GM and GM-CSF increased. Indometophen administration induced unstable changes in the number of CFU and CFU-GM, elevation of GM-CSF within 1-14 days, stimulation of CFU proliferative activity within 24 hours, inhibition of CFU-HM proliferation in 1 and 6 days. After radiation, in prodigiosan- and indometophen-defended cultures radiation damage declined while postradiation recovery of CFU, CFU-GM and total number of myelokaryocytes was more active.
Lebedev
V G
VG
Moroz
B B
BB
Vorotnikova
T V
TV
Deshevoĭ
Iu B
IuB
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay / Q000706:statistics & numerical data; D003692:Delayed-Action Preparations; D006410:Hematopoiesis / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D007111:Immunity, Cellular / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011354:Prodigiozan / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D003692:Delayed-Action Preparations; D011837:Radiation-Protective Agents; C091454:indometafen; D013629:Tamoxifen; D011354:Prodigiozan