Entrainment function in the suprachiasmatic nucleus of streptozotocin-induced diabetic rats.
The term for re-entrainment to a new light-dark cycle in streptozotocin (STZ)-induced diabetic rats was significantly longer than that in control rats. In STZ-induced diabetic rats, the same level of phase delay in the suprachiasmatic nucleus neuronal firing rhythm was observed in control rats after glutamate application. Therefore, 5-HT function in the hypothalamus is thought to be decreased in STZ-induced diabetic rats. These results suggest that postsynaptic neuronal function is still maintained in the suprachiasmatic nucleus of STZ-induced diabetic rats. Therefore, 5-HT mechanisms may play an important role in the maintenance of this function.
Shimazoe
T
T
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Ishida
J
J
Maetani
M
M
Yakabe
T
T
Yamaguchi
M
M
Miyasaka
K
K
Kono
A
A
Watanabe
S
S
Funakoshi
A
A
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D018698:Glutamic Acid / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D013311:Streptozocin; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology
D012701:Serotonin; D018698:Glutamic Acid; D006897:Hydroxyindoleacetic Acid; D013311:Streptozocin; D006916:5-Hydroxytryptophan