title: New pyrazolo[3,4-b]pyrazines: synthesis and biological activity.
abstract: Some new pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized and evaluated for their antifungal and antiparasitic activities. The key intermediate, 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile (3) was obtained in a one-pot synthesis via the reaction of 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 2 with malononitrile.
authors.affiliation: Chemistry Department, Faculty of Science, Assiut University, Egypt. elkashef@aun.eun.eg
authors.forename: H S
authors.initials: HS
authors.lastname: el-Kashef
authors.forename: T I
authors.initials: TI
authors.lastname: el-Emary
authors.forename: M
authors.initials: M
authors.lastname: Gasquet
authors.forename: P
authors.initials: P
authors.lastname: Timon-David
authors.forename: J
authors.initials: J
authors.lastname: Maldonado
authors.forename: P
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007891:Leishmania / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010271:Parasites / Q000187:drug effects*; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014246:Trichomonas vaginalis / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D011719:Pyrazines; D011720:Pyrazoles