[Solcoseryl in intensive therapy in severe craniocerebral trauma].
The state of processes of lipid peroxidation and antioxidant defense was studied in patients with severe isolated craniocerebral closed injury. It was found that starting from the first days in the hospital the patients demonstrated marked alterations in the thiol-disulfide and ascorbate metabolism, activation of lipid peroxidation processes and lower antioxidant defense. The use of Solcoseryl as a component of the antioxidant therapy in treatment of the above mentioned category of patients resulted in considerably better indices of the thiol-disulfide metabolism. The isolated use of Solcoseryl failed to influence the ascorbate metabolism and lipid peroxidation. Solcoseryl used in combination with the ascorbic acid led to normalization of the thiol-disulfide and ascorbade metabolism without influencing the lipid peroxidation processes. Combined use of Solcoseryl and ascorbic acid promoted normalization of the neurological status and stabilization of the arterial pressure level.
Marusanov
V E
VE
Miroshnichenko
A G
AG
Nikolau
S A
SA
Petrova
N V
NV
Bichun
A B
AB
D000183:Actihaemyl / Q000627:therapeutic use*; D000208:Acute Disease; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000378:metabolism / Q000627:therapeutic use; D006259:Craniocerebral Trauma / Q000188:drug therapy* / Q000378:metabolism; D003422:Critical Care / Q000379:methods*; D004359:Drug Therapy, Combination; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013997:Time Factors
D000975:Antioxidants; D005609:Free Radicals; D013438:Sulfhydryl Compounds; D000183:Actihaemyl; D001205:Ascorbic Acid