title: A new three-dimensional dose distribution reduction scheme for tubular organs.
abstract: In tubular structures, spatial aspects of the dose distribution may be important in determining the normal tissue response. Conventional dose-volume-histograms (DVHs) and dose-surface-histograms (DSHs) lack spatial information and may not be adequate to represent the three-dimensional (3D) dose data. A new 3D dose distribution data reduction scheme which preserves its longitudinal and circumferential character is presented. Dose distributions were generated at each axial level for esophagus or rectum in 123 patients with lung cancer or prostate cancer. Dose distribution histograms at each axial level were independently analyzed along the esophageal or rectal circumference to generate dose-circumference-histogram (DCH) sheets. Two types of plots were then generated from the DCH sheet. The first considered the percentage of the circumference at each axial level receiving various doses. The second considered the minimum dose delivered to any percentage of the circumference at each axial level. The DCH as a treatment planning tool can be easily implemented in a 3D planing system and is potentially useful for the study of the relationship between the complication risk and the longitudinal and circumferential dose distributions.
authors.affiliation: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA. zhou@radonc.duke.edu
authors.forename: S M
authors.initials: SM
authors.lastname: Zhou
authors.forename: L B
authors.initials: LB
authors.lastname: Marks
authors.forename: G S
authors.initials: GS
authors.lastname: Tracton
authors.forename: G S
authors.initials: GS
authors.lastname: Sibley
authors.forename: K L
authors.initials: KL
authors.lastname: Light
authors.forename: P D
authors.initials: PD
authors.lastname: Maguire
authors.forename: M S
authors.initials: MS
authors.lastname: Anscher
mesh_terms: D004307:Dose-Response Relationship, Radiation; D004947:Esophagus / Q000528:radiation effects; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012007:Rectum / Q000528:radiation effects; D012984:Software