Effect of prenatal stress on proliferative activity and chromosome aberrations in embryo brain in rats with different excitability of the nervous system.
Stress during pregnancy affects the morphogenesis of embryonal brain, its structural and functional characteristics, and behavior of the progeny. Genetic mechanisms of this process remain unclear. Cytogenetic characteristics of neuroblasts were analyzed in 17-18-day embryos of rats selected by threshold excitability of the nervous system in health and after emotional painful stress during the third trimester of pregnancy. The strains differed by the effect of stress on proliferative activity and chromosome aberrations in cells of the future hippocampus depending on the strain-specific characteristics of the nervous system excitability. This effect is regarded as an important component of epigenetic regulation of neurogenesis and behavior.
Vaido
A I
AI
Laboratory of Genetics of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Shiryaeva
N V
NV
Vshivtseva
V V
VV
D000818:Animals; D001921:Brain / Q000002:abnormalities / Q000196:embryology / Q000502:physiology*; D002455:Cell Division; D002869:Chromosome Aberrations; D005314:Embryonic and Fetal Development; D005260:Female; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D013312:Stress, Physiological / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*