A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding.
Akdis
C A
CA
Swiss Institute of Allergy and Asthma Research (SIAF), CH-7270 Davos, Switzerland. akdisac@siaf.unizh.ch
Joss
A
A
Akdis
M
M
Faith
A
A
Blaser
K
K
D000938:Antigen-Presenting Cells / Q000276:immunology; D018106:CD28 Antigens / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000502:physiology*; D008213:Lymphocyte Activation / Q000276:immunology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010766:Phosphorylation; D018123:Receptors, Interleukin / Q000378:metabolism*; D053701:Receptors, Interleukin-10; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D014443:Tyrosine / Q000378:metabolism
D018106:CD28 Antigens; D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10; D016753:Interleukin-10; D014443:Tyrosine; D019869:Phosphatidylinositol 3-Kinases