title: Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor.
abstract: The intestinal permeability of benzamidine analogue thrombin inhibitor is correlated with molecular volume, lipophilicity (calculated log P and IAM column capacity factor), hydrogen bond acidity/basicity and dipolarity.
authors.affiliation: Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd, Shizuoka, Japan. suganokyh@chugai-pharm.co.jp
authors.forename: K
authors.initials: K
authors.lastname: Sugano
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Takaku
authors.forename: M
authors.initials: M
authors.lastname: Haramura
authors.forename: R
authors.initials: R
authors.lastname: Saitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Nabuchi
authors.forename: H
authors.initials: H
authors.lastname: Ushio
mesh_terms: D001550:Benzamidines / Q000493:pharmacokinetics*; D007413:Intestinal Mucosa / Q000378:metabolism*; D010539:Permeability; D021281:Quantitative Structure-Activity Relationship; D012995:Solubility; D013917:Thrombin / Q000037:antagonists & inhibitors*
chemical_list: D001550:Benzamidines; D013917:Thrombin