title: 5-HETE congeners as modulators of cell proliferation.
abstract: The synthesis and assessment of the mitogenic properties of 5-HETE congeners are reported. These studies represent an effort to develop a structure-activity profile for ligands of the 5-HETE/5-oxoETE G-protein coupled receptor(s). Many of these agents possess mitogenic activity that equals or exceeds that of racemic 5-HETE family constituents in prostate cancer cell lines.
authors.affiliation: Departnent of Chemistry, University of Virginia, Charlottesville 22901, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Ghosh
authors.forename: C E
authors.initials: CE
authors.lastname: Myers
authors.forename: T L
authors.initials: TL
authors.lastname: Macdonald
mesh_terms: D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000494:pharmacology*; D008934:Mitogens / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D006893:Hydroxyeicosatetraenoic Acids; D008934:Mitogens; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid