title: Eradication of non-typhoid salmonellae in acute enteritis after therapy with ofloxacin for 5 or 10 days.
abstract: Eradication of non-typhoid salmonellae was evaluated in a randomized, double-blinded study of 49 patients with acute enteritis after therapy with ofloxacin 400 mg once daily for 5 or 10 days. Early eradication of salmonellae was found in 57% of patients in the 5 day therapy group and in 74% of patients in the 10 day therapy group. This difference was larger among severely ill patients. Together with our previous study of ofloxacin therapy for 3 days or placebo, this shows that early eradication of non-typhoid salmonellae increases with duration of ofloxacin therapy without an increase in persistence of salmonellae in stools or development of resistant strains.
authors.affiliation: Department of Infectious Diseases Prevention, City of Bergen, Norway. pal.voltersvik@vir.uib.no
authors.forename: P
authors.initials: P
authors.lastname: Voltersvik
authors.forename: A
authors.initials: A
authors.lastname: Halstensen
authors.forename: N
authors.initials: N
authors.lastname: Langeland
authors.forename: A
authors.initials: A
authors.lastname: Digranes
authors.forename: L E
authors.initials: LE
authors.lastname: Peterson
authors.forename: T
authors.initials: T
authors.lastname: Rolstad
authors.forename: C O
authors.initials: CO
authors.lastname: Solberg
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D004751:Enteritis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D012475:Salmonella / Q000302:isolation & purification; D012480:Salmonella Infections / Q000188:drug therapy* / Q000382:microbiology; D012477:Salmonella enteritidis / Q000302:isolation & purification; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D015242:Ofloxacin