title: The efficacy of topical prophylactic antiglaucoma therapy in primary closed angle glaucoma in dogs: a multicenter clinical trial.
abstract: The ability of either 0.5% betaxolol (1 drop topically, bid; n=31) or a combination of 0.25% demecarium bromide and a topical corticosteroid (gentamicin/betamethasone) (DB/GB; 1 drop of each topically, sid; n=55) to prevent glaucoma in the fellow eye of dogs with unilateral, primary closed angle glaucoma (PCAG) was investigated in a multicenter, open-label, clinical trial. Untreated control dogs (n=20) developed glaucoma significantly sooner (median, eight mos; p less than 0.001) than dogs treated either with DB/GB (median, 31 mos) or betaxolol (median, 30.7 mos). Although DB/GB and betaxolol equally delayed or prevented the onset of glaucoma in the second eye, a less frequent dosing schedule for DB/GB suggests demecarium bromide in combination with a topical corticosteroid may be preferable to betaxolol in preventing PCAG in dogs.
authors.affiliation: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 53706-1102, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Miller
authors.forename: G M
authors.initials: GM
authors.lastname: Schmidt
authors.forename: S J
authors.initials: SJ
authors.lastname: Vainisi
authors.forename: J F
authors.initials: JF
authors.lastname: Swanson
authors.forename: M K
authors.initials: MK
authors.lastname: Herrmann
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001623:Betamethasone / Q000008:administration & dosage; D015784:Betaxolol / Q000008:administration & dosage*; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000401:mortality / Q000517:prevention & control*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage; D015812:Glaucoma, Angle-Closure / Q000517:prevention & control / Q000662:veterinary*; D005938:Glucocorticoids; D008297:Male; D008916:Miotics / Q000008:administration & dosage*; D011446:Prospective Studies; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D004338:Drug Combinations; D005839:Gentamicins; D005938:Glucocorticoids; D008916:Miotics; D000644:Quaternary Ammonium Compounds; D001623:Betamethasone; C100193:demecarium; D015784:Betaxolol