Antihypertensive therapy and progression of chronic renal disease.
This paper reviews findings on the relationship between blood pressure control and the progression of renal disease. Experimental studies demonstrate a correlation between systemic blood pressure and histologic glomerular injury and the delay in progression of renal disease with antihypertensive therapy, particularly with angiotensin-converting enzyme inhibitors. Recent clinical findings are reviewed, including epidemiologic data linking hypertension to subsequent renal disease, and clinical studies showing a beneficial effect on progression of renal disease with lower than usual blood pressure targets.
Dworkin
L D
LD
Department of Medicine, Brown University School of Medicine, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA.
Shemin
D G
DG
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002908:Chronic Disease; D018450:Disease Progression; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D007674:Kidney Diseases / Q000503:physiopathology*; D011379:Prognosis
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers