title: Noninvasive perilymphatic pressure measurement in patients with Ménière's disease and patients with idiopathic sudden sensorineural hearing loss.
abstract: OBJECTIVE
  Inner ear disorders are proposed to be affected by changes in inner ear hydrostatic pressure. In humans, the perilymphatic hydrostatic pressure can be assessed in a noninvasive way with the MMS-10 Tympanic Displacement Analyser. In this study, measurements were performed in patients with Ménière's disease and patients with idiopathic sudden sensorineural hearing loss (ISSHL), and the results were compared with those of normal hearing ears. The measurement technique has been evaluated as a possible additional diagnostic tool for Ménière's disease or ISSHL.
  
  
  METHODS
  The hydrostatic perilymphatic pressure was measured noninvasively with the MMS-10 Tympanic Displacement Analyser.
  
  
  METHODS
  Department of Otorhinolaryngology at the University Hospital.
  
  
  METHODS
  Seventy-seven patients with Ménière's disease, 28 patients with ISSHL, and 50 normal hearing subjects.
  
  
  METHODS
  Diagnostic.
  
  
  METHODS
  Significant differences of perilymphatic pressure measurement results, represented by the measurement parameters Vi and Vm, in affected, nonaffected, and normal hearing ears.
  
  
  RESULTS
  On average, the measurement results showed no significant differences between affected (by Ménière's disease or ISSHL), nonaffected, and normal hearing ears.
  
  
  CONCLUSIONS
  In affected ears, perilymphatic pressure measured noninvasively did not differ significantly from the pressure in nonaffected and normal hearing ears. The tympanic membrane displacement technique cannot be considered an additional tool to confirm or reject the diagnosis of Ménière's disease or ISSHL.
authors.affiliation: Isala Clinics, Zwolle, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Rosingh
authors.forename: F W
authors.initials: FW
authors.lastname: Albers
authors.forename: H P
authors.initials: HP
authors.lastname: Wit
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D008575:Meniere Disease / Q000150:complications*; D008875:Middle Aged; D010498:Perilymph / Q000502:physiology*; D011312:Pressure; D012018:Reflex / Q000502:physiology; D013199:Stapes / Q000502:physiology; D014432:Tympanic Membrane / Q000502:physiology