title: Mucinous carcinoma of the breast with neuroendocrine differentiation.
abstract: A case of mucinous carcinoma of the breast with neuroendocrine differentiation in an 89-year-old woman is presented. The patient presented with a rapidly growing right breast mass, which she had had for 2-3 years. The tumor, 15 x 8 x 5 cm, was located mainly in the upper outer quadrant. Light microscopy revealed a pure mucinous carcinoma of type B. Neuroendocrine differentiation was demonstrated by Grimelius stain and chromogranin A, as well as the presence of neurosecretory granules. The breast cancer cells were of luminal origin and had dedifferentiated to attain neuroendocrine properties.
authors.affiliation: Department of Pathology, Kansai Medical University, Moriguchi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: N
authors.initials: N
authors.lastname: Shikata
authors.forename: H
authors.initials: H
authors.lastname: Senzaki
authors.forename: Y
authors.initials: Y
authors.lastname: Uemura
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Kashu
authors.forename: A
authors.initials: A
authors.lastname: Tsubura
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015413:Mastectomy, Simple; D008854:Microscopy, Electron; D009363:Neoplasm Proteins / Q000032:analysis; D009490:Neurosecretory Systems / Q000737:chemistry
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins