IgCAMs: bidirectional signals underlying neurite growth.
Understanding how immunoglobulin superfamily cell adhesion molecules (IgCAMs) regulate nervous system development has lagged behind studies on integrins and cadherins. The recent characterization of IgCAM structures combined with cell biological studies on protein-protein interactions and membrane targeting/trafficking demonstrate that IgCAMs interact in exceedingly complex ways to regulate axonal growth and pathfinding.
Kamiguchi
H
H
Developmental Brain Science Group, RIKEN Brain Science Institute (BSI), 2-1 Hirosawa, Saitama 351-0198, Wako, Japan. kamiguchi@brain.riken.go.jp
Lemmon
V
V
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology; D016501:Neurites / Q000502:physiology*; D015398:Signal Transduction
D015815:Cell Adhesion Molecules