title: Factors influencing first remission and survival in 145 dogs with lymphoma: a retrospective study.
abstract: Records of 145 dogs diagnosed with lymphoma were reviewed to evaluate for factors influencing duration of remission and survival. Dogs with histories of certain chronic inflammatory diseases were 3.23 times more likely to relapse (relative risk, 3.23) than the overall population. Dogs with World Health Organization (WHO) stage IV lymphoma or those treated with a protocol containing cyclophosphamide, doxorubicin, vincristine, prednisone, and sulfatrimethoprim (CHOP) had lower relative risks of relapse (0.32 and 0.085, respectively). Progressive disease after induction, gastrointestinal toxicity from induction, and clinical signs (i.e., substage b lymphoma) were associated with higher relative risks of death (3.5, 2.64, and 2.02, respectively).
authors.affiliation: Department of Veterinary Clinical Sciences and Comprehensive Cancer Center, College of Veterinary Medicine, The Ohio State University, Columbus 43210-1089, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Baskin
authors.forename: C G
authors.initials: CG
authors.lastname: Couto
authors.forename: T E
authors.initials: TE
authors.lastname: Wittum
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000188:drug therapy / Q000401:mortality*; D004285:Dogs; D005260:Female; D008223:Lymphoma / Q000188:drug therapy / Q000401:mortality / Q000662:veterinary*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000662:veterinary*; D009820:Ohio / Q000453:epidemiology; D011996:Records / Q000662:veterinary; D012074:Remission Induction; D012189:Retrospective Studies; D016019:Survival Analysis