[The usefulness of serum KL-6 levels for the diagnosis of disease activity in idiopathic interstitial pneumonia].
Serum KL-6 levels were measured in 29 patients with idiopathic interstitial pneumonia (IIP) as a means of evaluating disease activity. Levels of serum KL-6 were significantly higher in patients with active IIP (n = 11) than in those with inactive IIP (n = 18). The levels of serum KL-6 were 2,546 +/- 1,703 U/ml in patients with active IIP and 795 +/- 385 U/ml in patients with inactive IIP, respectively. The levels of serum LDH, CEA, P-III-P, and 7 S collagen in patients with active IIP did not differ significantly from those in patients with inactive IIP. For the diagnosis of active IIP, the sensitivity of serum KL-6 (cut off value of 1,500 U/ml) was 81.8% and the specificity, 94.4%. These results were almost identical to findings obtained with chest Ga-67 scintigraphy. Furthermore, they suggested that serum KL-6 levels may be a useful marker for the diagnosis of disease activity in IIP, as well as a useful indicator for the administration of steroid therapy to patients with IIP.
Totani
Y
Y
Third Department of Internal Medicine, Fukui Medical University, Japan.
Demura
Y
Y
Ameshima
S
S
Ishizaki
T
T
Miyamori
I
I
D000368:Aged; D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood; D005260:Female; D005710:Gallium Radioisotopes; D006023:Glycoproteins; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D017563:Lung Diseases, Interstitial / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity
D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D005710:Gallium Radioisotopes; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D010446:Peptide Fragments; D011347:Procollagen; D019275:Radiopharmaceuticals; C041876:procollagen Type III-N-terminal peptide