[A comparative evaluation of treatment methods for a genital papillomavirus infection in women with different viral genotypes].
Such genotypes of human papilloma virus (HPV) as "malignant" (180), "benign" (49) and indeterminate (127) were identified in 356 females by PCR and cytological procedures. The following therapeutic techniques were compared: cryodestruction of the uterine cervix (60), antiviral medication (AVM) (19), combination of AVM and cryodestruction (224), and combination of AVM and laser destruction (54). In the "malignant" HPV group, AVM in conjunction with cryo- or laser destruction was significantly more effective than cryodestruction or AVM alone. Both cryodestruction alone and in combination with AVM were more effective in treating "benign" genotypes. Repeat courses showed the same tendency.
Mikhaĭlov
I G
IG
N. N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Maksimov
S Ia
SIa
Novik
V I
VI
Safronnikova
N R
NR
Vishnevskiĭ
A S
AS
Prianishnikov
V A
VA
Lyshev
A A
AA
D000166:Acridines / Q000008:administration & dosage; D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000998:Antiviral Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003452:Cryosurgery; D004359:Drug Therapy, Combination; D005260:Female; D005831:Genital Diseases, Female / Q000628:therapy* / Q000821:virology; D005838:Genotype; D006801:Humans; D017075:Laser Coagulation; D027383:Papillomaviridae / Q000235:genetics* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000628:therapy* / Q000821:virology; D016133:Polymerase Chain Reaction; D013951:Thymus Hormones / Q000008:administration & dosage; D014412:Tumor Virus Infections / Q000628:therapy* / Q000821:virology; D014810:Vitamin E / Q000008:administration & dosage
D000166:Acridines; D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D013951:Thymus Hormones; D014810:Vitamin E; C077681:Camedon; C032805:thymalin