title: Bioavailability of praziquantel increases with concomitant administration of food.
abstract: In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the plasma concentration curve from 0 to 8 h increased 180 and 271%, respectively.
authors.affiliation: Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico.
authors.forename: N
authors.initials: N
authors.lastname: Castro
authors.forename: R
authors.initials: R
authors.lastname: Medina
authors.forename: J
authors.initials: J
authors.lastname: Sotelo
authors.forename: H
authors.initials: H
authors.lastname: Jung
mesh_terms: D000328:Adult; D000980:Antiplatyhelmintic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D018565:Food-Drug Interactions; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D011223:Praziquantel / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013607:Tablets
chemical_list: D000980:Antiplatyhelmintic Agents; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D013607:Tablets; D011223:Praziquantel