[The reactions of the immune system under the influence of a nonpeptide splenic factor].
The influence of low-molecular nonpeptide preparation splenosid obtained from bovine spleen on the cytotoxic activity of natural killers, reaction of complement binding and the immune responsibility was investigated. It was shown that even single treatment of rats with splenosid in a dose of 300 mkg/100 g in 48 hours stimulates the cytolytic activity of splenocytes on target cells (sheep erythrocytes). The same results were obtained in vitro. The treatment of guinea pigs with splenosid reduces the complement activity in serum. This preparation depresses the splenocyte immunoreactivity in sensibilized mice in a dose-dependent manner. The data obtained complete our knowledges about biological activity of splenosid.
Tron'ko
M D
MD
V. P. Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev.
Bynkova
L M
LM
Boĭko
M H
MH
Synel'nukova
H L
HL
Oliĭnyk
B V
BV
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D002417:Cattle; D015941:Complement Hemolytic Activity Assay; D003602:Cytotoxicity, Immunologic / Q000187:drug effects / Q000276:immunology; D006168:Guinea Pigs; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D009705:Nucleosides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D014020:Tissue Extracts / Q000494:pharmacology*
D001685:Biological Factors; D009705:Nucleosides; D014020:Tissue Extracts