title: C-reactive protein in the arterial intima: role of C-reactive protein receptor-dependent monocyte recruitment in atherogenesis.
abstract: Infiltration of monocytes into the arterial wall is an early cellular event in atherogenesis. Recent evidence shows that C-reactive protein (CRP) is deposited in the arterial intima at sites of atherogenesis. In this study, we demonstrate that CRP deposition precedes the appearance of monocytes in early atherosclerotic lesions. CRP is chemotactic for freshly isolated human blood monocytes. A specific CRP receptor is demonstrated on monocytes in vitro as well as in vivo, and blockage of the receptor by use of a monoclonal anti-receptor antibody completely abolishes CRP-induced chemotaxis. CRP may play a major role in the recruitment of monocytes during atherogenesis.
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Torzewski
authors.forename: C
authors.initials: C
authors.lastname: Rist
authors.forename: R F
authors.initials: RF
authors.lastname: Mortensen
authors.forename: T P
authors.initials: TP
authors.lastname: Zwaka
authors.forename: M
authors.initials: M
authors.lastname: Bienek
authors.forename: J
authors.initials: J
authors.lastname: Waltenberger
authors.forename: W
authors.initials: W
authors.lastname: Koenig
authors.forename: G
authors.initials: G
authors.lastname: Schmitz
authors.forename: V
authors.initials: V
authors.lastname: Hombach
authors.forename: J
authors.initials: J
authors.lastname: Torzewski
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology; D001344:Autopsy; D002097:C-Reactive Protein / Q000276:immunology / Q000378:metabolism*; D002465:Cell Movement; D002478:Cells, Cultured; D002633:Chemotaxis / Q000502:physiology; D006801:Humans; D009000:Monocytes / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism*; D017539:Tunica Intima / Q000378:metabolism* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; C071581:CRP protein, human; D011971:Receptors, Immunologic; D002097:C-Reactive Protein