Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome.
Individuals with fibromyalgia (FM) and/or chronic fatigue syndrome (CFS) report arthralgias and myalgias. However, only persons with FM alone exhibit abnormal pain responses to mild levels of stimulation, or allodynia. We identify the abnormalities in the neuroendocrine axes that are common to FM and CFS as well as the abnormalities in central neuropeptide levels and functional brain activity that differentiate these disorders. These two sets of factors, respectively, may account for the similarities and differences in the pain experiences of persons with FM and CFS.
Bradley
L A
LA
Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, School of Medicine, 475 Boshell Diabetes Building, 1808 7th Avenue South, Birmingham, AL 35294, USA. larry.bradley@ccc.uab.edu
McKendree-Smith
N L
NL
Alarcón
G S
GS
D001921:Brain / Q000002:abnormalities / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D005356:Fibromyalgia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007031:Hypothalamus / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D001523:Mental Disorders / Q000150:complications; D009619:Nociceptors / Q000503:physiopathology; D010146:Pain / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology
D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone