Opioid receptor antagonism during early lactation results in the increased duration of nursing bouts.
High levels of mu opioid receptor activation during the postpartum period result in the disruption of ongoing maternal behavior. The role of physiological levels of endogenous opioids on the mediation of maternal behavior in postpartum females, however, has not been closely examined. The purpose of the present experiments was to examine the function of endogenous opioids during early and mid-lactation by treating postpartum females with the opioid antagonist naloxone and monitoring their behavioral interactions with pups. Although this treatment did not lead to any qualitative differences in the maternal behaviors measured (pup retrieval and grooming, nest building, grouping of pups, or crouching over pups), there was a quantitative difference in the amount of time the females spent with pups on the nest and actively nursing pups. Naloxone, given either systemically or centrally (intracerebroventricularly), resulted in prolonged nursing and nesting bouts. This effect, however, was only observed during the early lactation time point (postpartum days 5-7). Females tested later in lactation (postpartum days 10-12 or 12-14) did not display the increased nursing or nesting bouts in response to the antagonist. These data indicate that central opioids play a role in the duration of nursing bouts during early lactation.
Byrnes
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Tufts University School of Veterinary Medicine, 200 Westboro Rd., N. Grafton, MA 01536, USA. ebyrnes@infonet.tufts.edu
Rigero
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Bridges
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007276:Injections, Intraventricular; D007774:Lactation / Q000187:drug effects / Q000502:physiology*; D008425:Maternal Behavior / Q000187:drug effects*; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D009425:Nesting Behavior / Q000187:drug effects; D049590:Postpartum Period / Q000523:psychology; D051381:Rats; D017207:Rats, Sprague-Dawley
D009292:Narcotic Antagonists; D009270:Naloxone