The binding of cocaine to cyclodextrins.
Cocaine binds into beta-cyclodextrin, but not detectably into alpha- or gamma-cyclodextrin, in water solution. NMR studies indicate the geometry of the complex, which is confirmed by molecular mechanics calculations and binding studies on cocaine analogues and cyclodextrin dimers.
Nesna
N
N
Department of Chemistry, Columbia University, New York, NY 10027, USA.
Lou
J
J
Breslow
R
R
D003042:Cocaine / Q000737:chemistry / Q000378:metabolism*; D003505:Cyclodextrins / Q000737:chemistry / Q000378:metabolism*; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy
D003505:Cyclodextrins; D003042:Cocaine