Efficacy of fluconazole and liposome entrapped fluconazole for C. albicans induced experimental mycotic endophthalmitis in rabbit eyes.
OBJECTIVE
To study the efficacy of intravitreally injected plain and liposome encapsulated fluconazole in the doses of 100 and 200 microg in Candidal endophthalmitis in rabbit eyes.


METHODS
Endophthalmitis was induced by injecting Candida albicans (1000 CFU/0.1 ml). Seventy two hours after inoculation, plain and liposome encapsulated fluconazole (REVs) were injected. At day 16 sterility was studied using vitreous culture.


RESULTS
In the 100 & 200 microg plain fluconazole group, vitreous sterility was seen in 62.5% and 75%, respectively. In the liposome entrapped fluconazole a culture sterility of 25% and 50% for 100 microg and 200 microg, respectively, was seen.


CONCLUSIONS
Plain fluconazole in the dose of 100 and 200 microg was equally effective against Candidal endophthalmitis in rabbits, but a failure of 25-37.5% of the eyes to respond, discourages one from using fluconazole as a sole therapy. Liposome entrapped fluconazole was found to be inferior to plain fluconazole in this model.
Gupta
S K
SK
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi. skgup@hotmail.com
Dhingra
N
N
Velpandian
T
T
Jaiswal
J
J
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D016503:Drug Delivery Systems; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D007267:Injections; D008081:Liposomes; D008297:Male; D011817:Rabbits; D012449:Safety; D014822:Vitreous Body / Q000187:drug effects
D000935:Antifungal Agents; D008081:Liposomes; D015725:Fluconazole