In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica.
Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-alpha and nitric oxide (NuOmicron) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.
Cho
J Y
JY
Department of Immunopharmacology, R & D Center, Daewoong Pharmaceutical Co. Ltd., Sungnam 462-120, Korea. jae.cho@ucl.ac.uk
Baik
K U
KU
Yoo
E S
ES
Yoshikawa
K
K
Park
M H
MH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D007376:Interleukin-2 / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D010946:Plants, Medicinal / Q000737:chemistry*; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007376:Interleukin-2; D017705:Lignans; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide