title: Active conservation of noncoding sequences revealed by three-way species comparisons.
abstract: Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.
authors.affiliation: Center for Bioinformatics and Computational Genomics, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
authors.forename: I
authors.initials: I
authors.lastname: Dubchak
authors.forename: M
authors.initials: M
authors.lastname: Brudno
authors.forename: G G
authors.initials: GG
authors.lastname: Loots
authors.forename: L
authors.initials: L
authors.lastname: Pachter
authors.forename: C
authors.initials: C
authors.lastname: Mayor
authors.forename: E M
authors.initials: EM
authors.lastname: Rubin
authors.forename: K A
authors.initials: KA
authors.lastname: Frazer
mesh_terms: D000818:Animals; D017124:Conserved Sequence / Q000235:genetics*; D004285:Dogs; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013045:Species Specificity; D020506:Untranslated Regions / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D020506:Untranslated Regions