Some aspects of the immunotherapy of multiple sclerosis (literature review).
This article reviews some immunotherapeutic approaches, based on the concept of multiple sclerosis as a progressive autoimmune disease. A special attention is given to the experimental results building up the model of autoimmune cascade and determining the directions of pathogenic treatment. The reviewed literature data highlight the pros and cons of the results of the conducted clinical trials with immunoeffective agents: corticosteroids, nonspecific immunosuppressive and contemporary immunomodulatory agents. Attention is given to the studies of combined drug therapies and the views of contemporary investigators.
Manova
M G
MG
Department of Neurology, Higher Medical Institute, Plovdiv, Bulgaria.
Kostadinova
I I
II
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy; D009103:Multiple Sclerosis / Q000628:therapy*
D000276:Adjuvants, Immunologic; D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents