title: Positive atrial inotropic effect of dofetilide after cardioversion of atrial fibrillation or flutter.
abstract: The pure class III agent dofetilide was evaluated to determine its effect on atrial function after cardioversion of atrial fibrillation or flutter. Compared with placebo, dofetilide-treated patients had evidence of better atrial function after cardioversion, indicating that this agent has a positive atrial inotropic effect during the period of postcardioversion atrial stunning.
authors.affiliation: Boston Medical Center, Massachusetts 02118, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: DeCara
authors.forename: A
authors.initials: A
authors.lastname: Pollak
authors.forename: S
authors.initials: S
authors.lastname: Dubrey
authors.forename: R H
authors.initials: RH
authors.lastname: Falk
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D001282:Atrial Flutter / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D001783:Blood Flow Velocity / Q000187:drug effects; D004311:Double-Blind Method; D018618:Echocardiography, Doppler, Color; D004554:Electric Countershock; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D010627:Phenethylamines / Q000627:therapeutic use*; D026902:Potassium Channel Blockers; D012008:Recurrence; D013318:Stroke Volume / Q000187:drug effects; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000889:Anti-Arrhythmia Agents; D010627:Phenethylamines; D026902:Potassium Channel Blockers; D013449:Sulfonamides; C063533:dofetilide