title: Carbohydrate sulfotransferases in lymphocyte homing.
abstract: Sulfation is a critical modification in many instances of biological recognition. Early work in lymphocyte homing indicated that the endothelial ligands for L-selectin depended upon sulfation modifications. Subsequent studies showed that the two specific modifications, Gal-6-SO4 and GlcNAc-6-SO4, were present on actual biological ligands. Recently, a family of carbohydrate sulfotransferases capable of generating these modifications has been identified at the molecular level. Reconstitution experiments implicate members of this family as critical participants in lymphocyte homing.
authors.affiliation: Department of Respiratory Diseases, Roche Bioscience, Palo Alto, CA 94304-1397, USA.
authors.forename: S
authors.initials: S
authors.lastname: Hemmerich
authors.forename: S D
authors.initials: SD
authors.lastname: Rosen
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000737:chemistry; D002634:Chemotaxis, Leukocyte; D003001:Cloning, Molecular; D006801:Humans; D019041:L-Selectin / Q000378:metabolism*; D008024:Ligands; D008214:Lymphocytes / Q000166:cytology* / Q000201:enzymology* / Q000378:metabolism; D008969:Molecular Sequence Data; D010802:Phylogeny; D015238:Sulfotransferases / Q000145:classification / Q000235:genetics / Q000378:metabolism*
chemical_list: D002241:Carbohydrates; D008024:Ligands; D019041:L-Selectin; D015238:Sulfotransferases