title: Selecting beam weight and wedge filter on the basis of dose gradient analysis.
abstract: This study proposes an algorithm for selecting beam weight, wedge angle, and wedge orientation for three-dimensional radiation therapy treatment planning. According to dose gradient analysis, the necessary and sufficient condition for achieving a homogeneous dose over the target volume is that the total vector sum of the dose gradients of all beams be zero everywhere in the target volume. This study presents equations for calculating the beam weight, wedge angle, and collimator angle (because the collimator angle determines wedge orientation when beam direction is known) for treatment plans using two angled beams or three coplanar or noncoplanar beams. It also provides suggestions for calculations of treatment plans using more than three beams, for which many feasible solutions will be available. When tested using two clinical cases, this algorithm achieved homogeneous dose distributions over target volumes. With this algorithm, repeated manual adjustments are reduced, and the quality and efficiency of treatment planning are improved.
authors.affiliation: Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. jianrong.dai@stjude.org
authors.forename: J
authors.initials: J
authors.lastname: Dai
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000532:radiotherapy; D006801:Humans; D015233:Models, Statistical; D010307:Parotid Neoplasms / Q000532:radiotherapy; D017785:Photons / Q000627:therapeutic use; D011859:Radiography; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*