Fetal growth and blood pressure in a Danish population aged 31-51 years.
During the past decade, studies have shown an inverse association between birth weight and blood pressure and risk of coronary heart disease in adult life. From old public archives we were able to trace the birth records of 545 out of 905 persons (60.2%) aged 31-51 years who participated in the Ebeltoft Health Promotion Project in Denmark. We examined the associations between birth weight, length at birth, Ponderal Index and systolic and diastolic blood pressure. No associations were found for women. For men, the mean systolic blood pressure fell from 131.1 mmHg with a birth weight of less than 3300 g to 129.6 mmHg with a birth weight of more than 4000 g, and for diastolic blood pressure 81.6 mmHg to 80.3 mmHg, respectively. For men, the mean systolic blood pressure fell from 135.7 mm Hg with a birth length of 30-51 cm to 131.6 with a birth length of 55-62 cm, and for diastolic blood pressure 83.0 mmHg to 78.8 mmHg, respectively. The associations may reflect organ programming in fetal life.
Sørensen
H T
HT
Danish Epidemiology Science Centre, Department of Epidemiology and Social Medicine, University of Aarhus. hts@soci.au.dk
Thulstrup
A M
AM
Nørgdård
B
B
Engberg
M
M
Madsen
K M
KM
Johnsen
S P
SP
Olsen
J
J
Lauritzen
T
T
D000328:Adult; D001724:Birth Weight; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination; D016001:Confidence Intervals; D003718:Denmark / Q000453:epidemiology; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D006306:Health Surveys; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D007022:Hypotension / Q000453:epidemiology; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012016:Reference Values; D018570:Risk Assessment; D017678:Sex Distribution