title: Suppression of transient 40-Hz auditory response by haloperidol suggests modulation of human selective attention by dopamine D2 receptors.
abstract: Cognitive processes including selective attention may depend on synchronous activity of neurons at the gamma-band (around 40Hz). To determine the effect of neuroleptic challenge on transient auditory evoked 40-Hz response, simultaneous measurement of 122-channel magnetoencephalogram (MEG) and 64-channel electroencephalogram (EEG) was used. Either 2mg of dopamine D(2)-receptor antagonist haloperidol or a placebo was administered orally to 11healthy subjects in a double-blind randomized crossover design in two separate sessions. The subjects attended to tones presented to one ear and ignored those presented to the other ear. Haloperidol significantly suppressed the transient 40-Hz electric response to the attended stimuli, while no significant effect was observed in the electric responses to the unattended tones or in the magnetic responses. The present result suggests that dopamine D(2) receptors modulate selective attention.
authors.affiliation: Cognitive Brain Research Unit, Department of Psychology, PO Box 13, FIN-00014 University of Helsinki, Helsinki, Finland. jyrki.ahveninen@helsinki.fi
authors.forename: J
authors.initials: J
authors.lastname: Ahveninen
authors.forename: S
authors.initials: S
authors.lastname: Kähkönen
authors.forename: H
authors.initials: H
authors.lastname: Tiitinen
authors.forename: E
authors.initials: E
authors.lastname: Pekkonen
authors.forename: J
authors.initials: J
authors.lastname: Huttunen
authors.forename: S
authors.initials: S
authors.lastname: Kaakkola
authors.forename: R J
authors.initials: RJ
authors.lastname: Ilmoniemi
authors.forename: I P
authors.initials: IP
authors.lastname: Jääskeläinen
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001288:Attention / Q000187:drug effects / Q000502:physiology*; D018592:Cross-Over Studies; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004311:Double-Blind Method; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D017448:Receptors, Dopamine D2 / Q000502:physiology*
chemical_list: D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D006220:Haloperidol