Genomic fold assignment and rational modeling of proteins of biological interest.
The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.
Sauder
J M
JM
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. M_Sauder@fccc.edu
Dunbrack
R L
RL
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D016678:Genome; D006801:Humans; D008958:Models, Molecular; D017510:Protein Folding; D011506:Proteins
D011506:Proteins