The long-term complications of chemotherapy in childhood genitourinary tumors.
Combination chemotherapy, often in conjunction with surgery and external radiotherapy, is utilized in most children with tumors of the genitourinary tract. These chemotherapeutic agents are capable of causing a variety of delayed toxicities. Common late complications include cardiotoxicity associated with prior exposure to an anthracycline, pulmonary dysfunction, infertility in males due to prior therapy with alkylating agents, and secondary leukemia in individuals treated with epipodophyllotoxins.
Sklar
C A
CA
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
LaQuaglia
M P
MP
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D010053:Ovary / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects; D014565:Urogenital Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents