title: Effect of Vitex rotundifolia on immediate-type allergic reaction.
abstract: We investigated the effect of aqueous extract of Vitex rotundifolia (L.) (Verbenaceae) fruits (VRFE) on the immediate-type allergic reactions in vivo and in vitro. VRFE (10(-4)-1.0 g/kg) dose-dependently inhibited systemic allergic reaction induced by compound 48/80. When VRFE was employed in a systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. VRFE (5x10(-1) and 1.0 g/kg) inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. VRFE (10(-3)-1.0 mg/ml) also dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80 or anti-DNP IgE. Moreover, VRFE (10(-3) mg/ml) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-alpha production from RPMC. These results suggest that VRFE may be beneficial in the regulation of immediate-type allergic reaction.
authors.affiliation: College of Pharmacy, Woosuk University, Wanju, 565-701, Chonbuk, South Korea.
authors.forename: T Y
authors.initials: TY
authors.lastname: Shin
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: J P
authors.initials: JP
authors.lastname: Lim
authors.forename: E S
authors.initials: ES
authors.lastname: Suh
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeong
authors.forename: B D
authors.initials: BD
authors.lastname: Kim
authors.forename: E J
authors.initials: EJ
authors.lastname: Park
authors.forename: W J
authors.initials: WJ
authors.lastname: Hwang
authors.forename: D G
authors.initials: DG
authors.lastname: Rye
authors.forename: S H
authors.initials: SH
authors.lastname: Baek
authors.forename: N H
authors.initials: NH
authors.lastname: An
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000818:Animals; D006636:Histamine Release / Q000187:drug effects; D006969:Hypersensitivity, Immediate; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha