Central nervous system norepinephrine metabolism in hypertension.
Although the pivotal role played by the brain in the maintenance of optimal physiologic and psychologic health has long been recognized, methods for the direct examination of human central nervous system processes have only recently been developed. A growing body of evidence indicates that central nervous systemmonoaminergic cell groups, in particular those utilizing norepinephrine as their neurotransmitter, participate in the excitatory regulation of the sympathetic nervous system and the development of the hypertensive state.
Lambert
G W
GW
Human Neurotransmitters Laboratory, Baker Medical Research Institute, PO Box 6492, St. Kilda Road Central, Melbourne, Victoria 8008, Australia. gavin@baker.edu.au
D000316:Adrenergic alpha-Agonists / Q000378:metabolism*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000378:metabolism / Q000503:physiopathology; D013566:Sympathomimetics / Q000378:metabolism*
D000316:Adrenergic alpha-Agonists; D018377:Neurotransmitter Agents; D013566:Sympathomimetics; D009638:Norepinephrine