[Investigation of corneal autofluorescence in diabetic patients].
OBJECTIVE
The investigation of corneal autofluorescence in diabetic patients.


OBJECTIVE
Corneal autofluorescence was investigated with a newly-developed fluorophotometer (wave length: excitation, 290-390 nm; emission, 430-630 nm) having, fluorescence characteristics involving those of reduced pyridine nucleotides (PN) and advanced glycation endoproduct (AGE) except pentosidine and pyrraline. Twenty-eight patients with non-insulin-dependent diabetes mellitus and sixty-seven healthy volunteers were studied.


RESULTS
The corneal autofluorescence was 1.65 times higher than that of controls (p < 0.0001). In non-insulin-dependent diabetes mellitus, the corneal autofluorescence was not correlated significantly with various diabetic parameters in blood (r < 0.4). In controls, the corneal autofluorescence was correlated significantly with age (r = 0.438).


CONCLUSIONS
The corneal autofluorescence has some relation with PN and AGE accumulation in the cornea.
Ishino
Y
Y
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
Yokoi
N
N
Yasuhara
T
T
Yamasaki
T
T
Koizumi
K
K
Ikeda
T
T
Kinoshita
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003315:Cornea / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D005453:Fluorescence; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009711:Nucleotides / Q000378:metabolism
D017127:Glycation End Products, Advanced; D009711:Nucleotides