title: Treatment of fallopian tube cancer. Review of the literature.
abstract: OBJECTIVE
  To contribute toward the understanding of the therapeutic management of fallopian tube cancer.
  
  
  METHODS
  Recent studies related to the treatment of fallopian tube cancer were reviewed.
  
  
  RESULTS
  Current evidence indicates that even patients in early stages have nodal disease, and often experience relapses in distant sites. In advanced stages, survival prolongation by the use of platinum-based chemotherapy has been demonstrated. Aggressive cytoreductive surgery followed by chemotherapy and negative second-look laparotomy offer the possibility of long-term survival. However, a significant fraction of patients eventually relapses after negative second-look laparotomy, and a poor survival rate after positive second-look laparotomy has been observed.
  
  
  CONCLUSIONS
  This series suggests the need for thorough evaluation of lymph nodes at the time of surgery. The use of platinum-based chemotherapy is probably the best adjuvant therapy for both early stages and advanced stages. The clinical value of second-look laparotomy will remain limited until effective salvage therapy is developed. The potential benefits of neoadjuvant chemotherapy and the use of paclitaxel will be increasingly important.
authors.affiliation: Department of Gynecology, Cancer Institute Hospital, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takeshima
authors.forename: K
authors.initials: K
authors.lastname: Hasumi
mesh_terms: D005185:Fallopian Tube Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D007813:Laparotomy; D012086:Reoperation; D016019:Survival Analysis
chemical_list: D006728:Hormones