Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome.
OBJECTIVE
To evaluate the serum vascular endothelial growth factor concentrations and insulin responses to the oral glucose tolerance test before and after laparoscopic ovarian drilling in women with PCOS.


METHODS
Prospective study.


METHODS
University teaching center.


METHODS
Twenty-seven women with clomiphene citrate-resistant polycystic ovary syndrome.


METHODS
Laparoscopic ovarian drilling.


METHODS
VEGF levels and insulin responses to OGTT before and after ovarian drilling.


RESULTS
No difference was found in VEGF levels in women with PCOS before (6.0 +/- 1.2 ng/mL) and after ovarian drilling (5.5 +/- 1.2 ng/mL). VEGF levels before and after ovarian drilling in women who conceived were, respectively, 5.9 +/- 1.0 and 5.1 +/- 0.9 ng/mL and in those who did not conceive were 6.0 +/- 1.3 and 5.7 +/- 1.2 ng/mL. No correlation was found between baseline serum insulin and VEGF levels. VEGF concentrations in women with normal ovaries (4.5 +/- 1.7 ng/mL) were significantly lower than in women with PCOS. There was no difference in glucose and insulin responses to OGTT before and after ovarian drilling.


CONCLUSIONS
VEGF levels in women with PCOS are higher than in normal women, and ovarian drilling does not affect these levels. The procedure does not change insulin responses to OGTT.
Tulandi
T
T
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada. togas.tulandi@muhc.mcgill.ca
Saleh
A
A
Morris
D
D
Jacobs
H S
HS
Payne
N N
NN
Tan
S L
SL
D000704:Analysis of Variance; D002996:Clomiphene / Q000627:therapeutic use; D016228:Endothelial Growth Factors / Q000097:blood*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005951:Glucose Tolerance Test; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000601:surgery*; D007328:Insulin / Q000097:blood*; D010535:Laparoscopy; D008222:Lymphokines / Q000097:blood*; D010053:Ovary / Q000601:surgery*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000503:physiopathology* / Q000601:surgery*; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D005300:Fertility Agents, Female; D007328:Insulin; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D002996:Clomiphene