Conserved noncoding sequences are reliable guides to regulatory elements.
A 'working draft' of the human genome sequence is now available. Comparisons with the sequences of mouse and other species will be a powerful approach to identifying functional segments of the noncoding regions, such as gene regulatory elements. However, the choice of a species for most effective comparison differs among various loci.
Hardison
R C
RC
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA. rch8@psu.edu
D000818:Animals; D006801:Humans; D007378:Interleukins / Q000235:genetics; D051379:Mice; D012045:Regulatory Sequences, Nucleic Acid; D013045:Species Specificity
D007378:Interleukins