One-pot synthesis of unsymmetrical triarylamines from aniline precursors.
The "one-pot" synthesis of triarylamines from an aniline and two different aryl halides is described. A catalytic system composed of Pd2(dba)3/P(t-Bu)2-o-biphenyl (1) is used to prepare a variety of triarylamines in a single flask by the coupling of an aniline with an aryl bromide and aryl chloride. The synthesis of triarylamines containing a heterocyclic aryl group is also described by employing a one-flask, two-step method. These methods can be used to synthesize both discrete triarylamines and a triarylamine library.
Harris
M C
MC
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Buchwald
S L
SL
D000588:Amines / Q000138:chemical synthesis*; D000814:Aniline Compounds / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy
D000588:Amines; D000814:Aniline Compounds; C023650:aniline