Induction of glutathione S-transferase by prostaglandins.
Exposure of cells to a wide variety of chemoprotective compounds confers resistance to a broad set of carcinogens. For a subset of the chemoprotective compounds, protection is generated by an increase in the abundance of protective enzymes such as glutathione S-transferases (GSTs). We have recently developed a cell culture system that potently responds to the phenolic antioxidants upon induction of GST activity and found that the J(2) series of PGs, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) in particular, preferentially induces the synthesis of GSTs. The molecular mechanism underlying the 15d-PGJ(2)-induced GST expression has been elucidated.
Uchida
K
K
Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, 464-8601, Nagoya, Japan. uchidak@agr.nagoya-u.ac.jp
D000818:Animals; D002460:Cell Line; D004790:Enzyme Induction; D015870:Gene Expression / Q000187:drug effects; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*; D020218:Response Elements
D007527:Isoenzymes; D011465:Prostaglandins, Synthetic; C037112:9-deoxy-delta-9-prostaglandin D2; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D015230:Prostaglandin D2