title: Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex.
abstract: The integral membrane protein complex quinol-fumarate reductase catalyzes the terminal step of a major anaerobic respiratory pathway. The homologous enzyme succinate-quinone oxidoreductase participates in aerobic respiration both as complex II and as a member of the Krebs cycle. Last year, two structures of quinol-fumarate reductases were reported. These structures revealed the cofactor organization linking the fumarate and quinol sites, and showed a cofactor arrangement across the membrane that is suggestive of a possible energy coupling function.
authors.affiliation: Graduate Option in Biochemistry, California Institute of Technology, Pasadena 91125, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Iverson
authors.forename: C
authors.initials: C
authors.lastname: Luna-Chavez
authors.forename: I
authors.initials: I
authors.lastname: Schröder
authors.forename: G
authors.initials: G
authors.lastname: Cecchini
authors.forename: D C
authors.initials: DC
authors.lastname: Rees
mesh_terms: D000818:Animals; D004579:Electron Transport; D042963:Electron Transport Complex II; D004734:Energy Metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D010088:Oxidoreductases / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D011809:Quinones / Q000737:chemistry* / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000737:chemistry* / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D011809:Quinones; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase