title: Competitive exclusion of Salmonella enteritidis by Salmonella gallinarum in poultry.
abstract: Salmonella Enteritidis emerged as a major egg-associated pathogen in the late 20th century. Epidemiologic data from England, Wales, and the United States indicate that S. Enteritidis filled the ecologic niche vacated by eradication of S. Gallinarum from poultry, leading to an epidemic increase in human infections. We tested this hypothesis by retrospective analysis of epidemiologic surveys in Germany and demonstrated that the number of human S. Enteritidis cases is inversely related to the prevalence of S. Gallinarum in poultry. Mathematical models combining epidemiology with population biology suggest that S. Gallinarum competitively excluded S. Enteritidis from poultry flocks early in the 20th century.
authors.affiliation: Robert Koch Institute, Wernigerode, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Rabsch
authors.forename: B M
authors.initials: BM
authors.lastname: Hargis
authors.forename: R M
authors.initials: RM
authors.lastname: Tsolis
authors.forename: R A
authors.initials: RA
authors.lastname: Kingsley
authors.forename: K H
authors.initials: KH
authors.lastname: Hinz
authors.forename: H
authors.initials: H
authors.lastname: Tschäpe
authors.forename: A J
authors.initials: AJ
authors.lastname: Bäumler
mesh_terms: D000818:Animals; D002645:Chickens; D004196:Disease Outbreaks; D004531:Eggs / Q000382:microbiology; D004812:Epidemiologic Methods; D005516:Food Microbiology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008962:Models, Theoretical; D011159:Population Surveillance; D011201:Poultry Diseases / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies; D012480:Salmonella Infections / Q000453:epidemiology* / Q000635:transmission; D012481:Salmonella Infections, Animal / Q000453:epidemiology* / Q000517:prevention & control; D012477:Salmonella enteritidis / Q000472:pathogenicity*