title: Hysterectomy for obese women with endometrial cancer: laparoscopy or laparotomy?
abstract: OBJECTIVE
  The aim of this study was to investigate the feasibility and safety of laparoscopic management of obese women with early stage endometrial cancer and to compare the surgical outcome, cost, hospital stay, recall of postoperative pain control, time to return to full activity and to work, and overall satisfaction among these women and those managed by laparotomy.
  
  
  METHODS
  We conducted a prospective study over 2 years applying laparoscopic surgery to all women with clinical stage I endometrial cancer and body mass indices (BMIs) between 28.0 and 60.0 who can tolerate such surgery. As a control, we used women with clinical stage I endometrial cancer and similar BMIs who underwent laparotomy in the previous 2 years. Both groups were compared in their characteristics, surgical outcome, cost, and hospital stay, and interviewed regarding time to recovery, recall of postoperative pain control, and overall satisfaction with their management.
  
  
  RESULTS
  Forty of 42 obese women who presented with clinical stage I endometrial cancer during the study period were offered laparoscopic surgery. The procedure was converted to laparotomy in 3 (7.5%) patients. Laparoscopic surgery was thus successful in 88.1% of all obese women. There was no significant difference between women who underwent laparoscopy and those who underwent laparotomy in patient characteristics, proportion of women who underwent lymphadenectomy, complications, total cost, patients' recall of postoperative pain, and patients' satisfaction with management. Women who underwent laparoscopy had a significantly longer operative time, more pelvic lymph nodes removed, a smaller drop in postoperative hematocrit, less pain medication, and a shorter hospital stay (194.8 versus 137.7 min, P <0.001; 11.3 versus 5.3, P < 0.001; 3.9 versus 5.4, P = 0.029; 32.3 versus 124.1 mg, P < 0.001; and 2.5 versus 5.6 days, P < 0.001, respectively). There was a trend toward earlier resumption of full activity and return to work among women who underwent laparoscopy (23.2 versus 45.0 days, P = 0.073, and 35.3 versus 67.0 days, P = 0.055, respectively).
  
  
  CONCLUSIONS
  Most obese women with early stage endometrial cancer can be safely managed through laparoscopy with excellent surgical outcome, shorter hospitalization, and less postoperative pain than those managed through laparotomy.
authors.affiliation: Division of Gynecologic Oncology, University of Vermont College of Medicine, Burlington, Vermont 05401, USA.
authors.forename: G H
authors.initials: GH
authors.lastname: Eltabbakh
authors.forename: M I
authors.initials: MI
authors.lastname: Shamonki
authors.forename: J M
authors.initials: JM
authors.lastname: Moody
authors.forename: L L
authors.initials: LL
authors.lastname: Garafano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion; D016889:Endometrial Neoplasms / Q000473:pathology / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006400:Hematocrit; D006801:Humans; D007045:Hysterectomy, Vaginal / Q000009:adverse effects / Q000191:economics / Q000379:methods*; D007430:Intraoperative Care; D010535:Laparoscopy / Q000009:adverse effects / Q000191:economics / Q000379:methods; D007813:Laparotomy / Q000009:adverse effects / Q000191:economics / Q000379:methods; D008875:Middle Aged; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications*; D010149:Postoperative Pain / Q000188:drug therapy / Q000209:etiology; D011446:Prospective Studies; D012509:Sarcoma / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology / Q000601:surgery