Peculiarities of primary humoral immune response in mice with cytostatic disease.
Single intraperitoneal injection of cyclophosphamide in a maximum permissible dose (250 mg/kg) followed by immunization wih thymus-dependent antigen (sheep erythrocytes) markedly suppressed the formation of antibody-producing cells in the spleen, especially at early stages of cytostatic disease, and delayed the synthesis of specific antibodies in male CBA/CaLac mice. Platidiam (cisplatin) injected in comparable doses 4 days before immunization practically did not suppress the formation of antibody-producing cells and their functional activity, but being injected 30 days before immunization reduced the number of antibody-producing cells.
Masnaya
N V
NV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Ratner
G M
GM
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000276:immunology; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D051379:Mice
D000970:Antineoplastic Agents; D003520:Cyclophosphamide