Stress or drug priming induces reinstatement of extinguished conditioned place preference.
To construct a model for the relapse of drug use, we investigated the reinstatement of morphine-induced conditioned place preference (CPP) in rats. After the morphine CPP paradigm was established, rats were left extinguishing for 9 days, then exposed to 15 min of random foot shock or s.c. drug priming with different doses of morphine or amphetamine, respectively. Foot shock or a higher dose (0.25 mg/kg) of both drugs could reinstate the CPP induced by 4 mg/kg of morphine after a 9-day extinction, while a lower dose (0.125 mg/kg) of both drugs had no effect. It is concluded that the CPP extinction-reinstatement paradigm might be used as a model to investigate the mechanism of relapse in addicts.
Wang
B
B
Neuroscience Research Institute, Beijing Medical University, P. R. China.
Luo
F
F
Zhang
W T
WT
Han
J S
JS
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology*; D004597:Electroshock; D004777:Environment; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000523:psychology*; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D013028:Space Perception / Q000502:physiology*; D013312:Stress, Physiological / Q000523:psychology*
D000697:Central Nervous System Stimulants; D009294:Narcotics; D009020:Morphine; D000661:Amphetamine