Enolization of chiral alpha-silyloxy ketones with dicyclohexylchloroborane. Application to stereoselective aldol reactions
[reaction: see text]Comprehensive analysis of the enolization of alpha-silyloxyketones by Chx2BCl/R3N has allowed us to design stereoselective Chx2BCl-mediated aldol processes that afford syn or anti aldol products and to disclose a hypothesis that accounts for the subtle effects that determine their enolization.
Galobardes
M
Departament de Quimica Organica, Universitat de Barcelona, Catalonia, Spain.
Gascon
M
Mena
M
Romea
P
Urpi
F
Vilarrasa
J