title: HTLV-I-associated myelopathy manifested after renal transplantation.
abstract: We report a patient with HTLV-I-associated myelopathy (HAM), who developed symptoms of myelopathy 4 years after cadaveric renal transplantation. Since he was seronegative before the transplantation, it is suggested that HTLV-I infection was transmitted via renal graft transplantation. He has been treated with immunosuppressive agents such as cyclosporin A (CsA), mycophenolate mofetil (MMF), and prednisolone (PSL) to prevent graft rejection. This case suggested that these immunosuppressive agents are poorly effective in suppressing either the onset or progression of HAM/TSP.
authors.affiliation: Department of Neurology, Osaka University Graduate School of Medicine, Yamada-oka 2-2, Suita, 565-0871, Osaka, Japan. yuji@neurol.med.osaka-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Nakatsuji
authors.forename: F
authors.initials: F
authors.lastname: Sugai
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Kaido
authors.forename: K
authors.initials: K
authors.lastname: Koguchi
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Sakoda
mesh_terms: D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000473:pathology* / Q000635:transmission
chemical_list: D007166:Immunosuppressive Agents