[The effect of sodium alpha-ketoglutarate on the physical load endurance of rats with different resistances to hypoxia].
The studies have been performed in high- (HR) and low-resistant (LR) to hypoxia animals swimming to the point of exhaustion. It has been established that HR rats are capable to endure the dynamic load twice longer. The introduction of sodium alpha-ketoglutarate (SKG) increases the endurance of LR animals to the level of the HR ones, activates the aminotransferase mechanisms of ketoglutarate utilization and decreased tissue succinic dehydrogenase activity. SKG injection activates the cholinergic link of regulation in this conditions. Such functional reorganization in a body is directed to decreasing the energy expenses in HR and LR animals under relevant significant functional loads and restriction of the influence of lipid peroxidation products (determined by blood and tissue concentration of malonic dialdehyde) to cellular membrane.
Kurhaliuk
N M
NM
Ivan Franko Lviv National University, Ministry of Education of Ukraine.
D000410:Alanine Transaminase / Q000187:drug effects / Q000378:metabolism; D000531:Altitude; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects / Q000378:metabolism; D001273:Atmosphere Exposure Chambers; D017079:Exercise Tolerance / Q000187:drug effects* / Q000502:physiology; D000860:Hypoxia / Q000503:physiopathology*; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D013385:Succinate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D013550:Swimming
D007656:Ketoglutaric Acids; D008315:Malondialdehyde; D013385:Succinate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase