[Construction of original artificial immunogens--candidate vaccines against HIV-1].
An original method for making effective artificial vaccines has been developed. Immunogens are virus-like particles containing a DNA molecule covered with recombinant proteins carrying the pathogen epitopes. The recombinant proteins are exposed on the surface of the particle and are attached to DNA via spermidine-polygluquine-glutathione or galactopyranoside conjugates (depending on the hybrid protein composition). Two variants of artificial immunogens-candidates for antiHIV vaccine have been prepared.
Lebedev
L R
LR
State Virology and Biotechnology Center Vektor, Berdsk, Novosibirsk region.
Gileva
I P
IP
Karpenko
L I
LI
Eroshkin
A M
AM
D016915:AIDS Vaccines / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D002850:Chromatography, Gel; D004274:DNA, Recombinant; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000276:immunology; D015497:HIV-1 / Q000276:immunology; D008969:Molecular Sequence Data; D010957:Plasmids; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics*
D016915:AIDS Vaccines; D004274:DNA, Recombinant; D000939:Epitopes; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic