Antireproductive effect of the calcium channel blocker amlodipine in male rats.
The purpose of the present study was to investigate whether treatment of male rats with the calcium antagonist amlodipine, used in the treatment of hypertension and angina, interferes with the reproductive function of male rats. Amlodipine treatment (0.04 mg amlodipine besylate/rat/day for 30 days) decreased plasma follicle-stimulating hormone and testosterone but not luteinizing hormone or prolactin concentrations (measured by double-antibody radioimmuno-assay). A significant reduction (23%) was observed in sperm density (sperm suspension collected from the cauda epididymidis) as well as in the amount of mature spermatids (14%) and Sertoli cells (9%) counted in seminiferous tubule cross-sections (400 x magnification). The results reveal the deleterious effects of subacute amlodipine treatment on the reproductive function of male rats.
Almeida
S A
SA
Department of Morphology, Stomatology and Physiology, Dental School of Ribeirão Preto, University of São Paulo, Brazil.
Teófilo
J M
JM
Anselmo Franci
J A
JA
Brentegani
L G
LG
Lamano-Carvalho
T L
TL
D017311:Amlodipine / Q000009:adverse effects*; D000818:Animals; D002121:Calcium Channel Blockers / Q000009:adverse effects*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007248:Infertility, Male / Q000139:chemically induced; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013076:Sperm Count; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000097:blood
D002121:Calcium Channel Blockers; D017311:Amlodipine; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone