[Interest in variations in soluble ICAM-1 plasma levels. From physiology to clinical applications].
Intracellular adhesion molecule 1 (ICAM-1) is an adhesion-related molecule belonging to the immunoglobulin superfamily. This molecule is found on the cell membrane of endothelial cells. When activated ICAM-1 allows stable leukocyte adhesion to the endothelial surface. ICAM-1 is found not only in the membrane form but also circulating in serum. ICAM-1 (extracellular part of ICAM-1). This enables ICAM-1s to bind leukocyte integrin receptors such as LFA-1 (CDI1a/CD18) and Mac-1 (CDI1b/CD18) and therefore provide adaptive changes in the adhesion process between circulating cells and the endothelium.
Gomez-Scotto
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Laboratoire Universitaire d'Hématologie, Université Victor Ségalen, Bordeaux, France.
Seigneur
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Renard
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Houbouyan-Reveillard
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Boisseau
M R
MR
D002448:Cell Adhesion; D004194:Disease; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007962:Leukocytes / Q000502:physiology; D012016:Reference Values
D018799:Intercellular Adhesion Molecule-1