T-cell lineage fate: instructed by receptor signals?
Mechanisms of lineage choice represent a challenging problem in developmental biology. Recent studies have shown that different T-cell receptor signals can affect CD4 or CD8 lineage choice. Thus, all the ingredients for instructive mechanisms of lineage fate are in place but other mechanisms cannot be completely ruled out.
von Boehmer
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Harvard Medical School, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA. harald_von_boehmer@dfci.harvard.edu
D019070:Cell Lineage; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D019076:Transgenes
D011948:Receptors, Antigen, T-Cell