title: Orbital and dorsolateral frontal perfusion defect associated with behavioral response to cholinesterase inhibitor therapy in Alzheimer's disease.
abstract: The authors retrospectively explored the behavioral and functional imaging profile of Alzheimer's disease (AD) patients who respond to cholinesterase inhibitor therapy by using the Neuropsychiatric Inventory (NPI) and baseline [99mTc]HMPAO SPECT. Thirty AD patients were divided into three groups (Responders, Nonresponders, and Unchanged) based on their behavioral response to donepezil. Responders had significantly (P < or = 0.01) more pretreatment irritability, disinhibition (P < or = 0.05), and euphoria (P = 0.05) than Nonresponders and significantly lower lateral orbital frontal (P < 0.00001) and dorsolateral frontal (P < or = 0.0005) perfusion bilaterally. A pretreatment orbitofrontal syndrome may predict behavioral response to cholinesterase inhibitor therapy in AD.
authors.affiliation: Department of Neurology, UCLA School of Medicine 90095-1769, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Mega
authors.forename: I D
authors.initials: ID
authors.lastname: Dinov
authors.forename: L
authors.initials: L
authors.lastname: Lee
authors.forename: S M
authors.initials: SM
authors.lastname: O'Connor
authors.forename: D M
authors.initials: DM
authors.lastname: Masterman
authors.forename: B
authors.initials: B
authors.lastname: Wilen
authors.forename: F
authors.initials: F
authors.lastname: Mishkin
authors.forename: A W
authors.initials: AW
authors.lastname: Toga
authors.forename: J L
authors.initials: JL
authors.lastname: Cummings
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D001519:Behavior / Q000187:drug effects / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D011569:Psychiatric Status Rating Scales; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D014236:Trichlorfon / Q000627:therapeutic use
chemical_list: D002800:Cholinesterase Inhibitors; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D014236:Trichlorfon