Medical treatment of hypertrophic cardiomyopathy.
Current medical therapy of hypertrophic cardiomyopathy (HCM) is tailored to relieve symptoms of exercise intolerance, angina, or syncope. In recent years, new concepts in the pathophysiology of HCM have evolved. These concepts underlie our medical therapy and are discussed first in this review. Subsequently, the agents available for the medical treatment of HCM are discussed, along with a practical strategy for rapid medical reduction of outflow gradients. The mechanism of benefit of negative inotropes for obstruction is described, and newer agents under investigation are discussed. Finally, antiarrhythmic therapy for troubling atrial and ventricular arrhythmias is considered.
Sherrid
M V
MV
Hypertrophic Cardiomyopathy Program, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, Division of Cardiology, 3B-30, 1000 10th Avenue, New York, NY 10019, USA. msherrid@slrhc.org
Gunsburg
D
D
Sharma
A
A
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D002316:Cardiotonic Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging; D018608:Ultrasonography, Doppler
D002316:Cardiotonic Agents