title: [Stereotaxic precision irradiation of large uveal melanomas with the gamma knife].
abstract: BACKGROUND
  We report our experience with stereotactic radiosurgery using the Gamma-knife in large uveal melanoma unsuitable for brachytherapy (Ru106).
  
  
  METHODS
  We treated 35 patients (16 male, 19 female; age: median 59 years (95% Confidence interval (CI): 31-84 years; 18 right eyes, 17 left eyes). 7 tumors were located juxtapapillary, 16 tumors were located in the mid-periphery and 12 tumors were located in the ciliary body, The localization and/or the dimension of the tumors did not allow for radiation brachytherapy (Ru106). All patients underwent regular clinical, echographical and neuroradiological follow-up examinations.
  
  
  RESULTS
  The follow-up time was median 12 months (95% CI: 4-20 months). A local tumor control defined as either continuous tumor regression or stopping of tumor progression was achieved in 34 (97%) of the 35 treated patients within the observation period. The eye of one patient was enucleated due to tumor regrowth. Maximum apical tumor height according to standardized A-scan before treatment was median 9.1 mm (95% CI: 3.2-13.9 mm) and after treatment median 6.4 mm (95% CI: 2.1 bis 11.9 mm). The difference was statistically highly significant (p < 0.001, one-tailed paired t-test).
  
  
  CONCLUSIONS
  Our results in 35 patients indicate that radiosurgery using the Gamma-knife is beneficial in retaining the eyes of patients with large uveal melanomas that are not suitable for brachytherapy (Ru106).
authors.affiliation: Augenklinik LMU, München.
authors.forename: A J
authors.initials: AJ
authors.lastname: Mueller
authors.forename: S
authors.initials: S
authors.lastname: Talies
authors.forename: U C
authors.initials: UC
authors.lastname: Schaller
authors.forename: J P
authors.initials: JP
authors.lastname: Hoops
authors.forename: S
authors.initials: S
authors.lastname: Schriever
authors.forename: A
authors.initials: A
authors.lastname: Kampik
authors.forename: B
authors.initials: B
authors.lastname: Wowra
authors.forename: G
authors.initials: G
authors.lastname: Horstmann
authors.forename: A
authors.initials: A
authors.lastname: Mack
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D016634:Radiosurgery; D014602:Uvea / Q000473:pathology / Q000601:surgery; D014604:Uveal Neoplasms / Q000473:pathology / Q000601:surgery*