Bioactive compounds from Psorothamnus junceus.
During a search for bioactive compounds from Psorothamnus junceus, four heterocyclic compounds, psorothamnone A (1), psorothamnone B (2), dalrubone (3), and emorydone (4) were isolated from the ethanol extract of the stem bark. Psorothamnones A (1) and B (2) demonstrated inhibitory activity against protein kinase C (PKC), a key enzyme involved in the signal transduction of cell proliferation and differentiation. Dalrubone (3) and emorydone (4) showed cytotoxicity against several human tumor cell lines.
Zhang
H
H
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA.
Li
X
X
Ashendel
C L
CL
Chang
C J
CJ
D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D011493:Protein Kinase C