title: Effect of estrogen on cerebral glucose metabolism in postmenopausal women.
abstract: PET was used to evaluate the effect of estrogen use on regional cerebral glucose metabolism in postmenopausal women. Women receiving estrogen replacement therapy (ERT+), women not receiving estrogen (ERT-), and women with AD were studied. The ERT- group showed metabolic ratios that were intermediate to the ERT+ and AD groups, although they did not show any signs of cognitive impairment. These findings show an effect of estrogen depletion on brain metabolic activity.
authors.affiliation: Center for Functional Imaging Lawrence Berkeley Laboratory, University of California, Berkeley, CA, USA. eberling@cfi.lbl.gov
authors.forename: J L
authors.initials: JL
authors.lastname: Eberling
authors.forename: B R
authors.initials: BR
authors.lastname: Reed
authors.forename: J E
authors.initials: JE
authors.lastname: Coleman
authors.forename: W J
authors.initials: WJ
authors.lastname: Jagust
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D004967:Estrogens; D005947:Glucose