title: Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women.
abstract: OBJECTIVE
  To determine trends in the epidemiology of vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva in a Central European sample during the last decade.
  
  
  METHODS
  A total of 366 women with VIN 2 and 3 (n = 128) or vulvar SCC (n = 238) presented within two four-year periods separated by one decade (1985-1988 and 1994-1997). We performed a retrospective analysis of the clinicopathologic records of the cohorts.
  
  
  RESULTS
  The number of women with high grade VIN (n = 29 vs. 99) tripled during the last decade, while the incidence of vulvar SCC remained stable. In women < or = 50 years old, the incidence of high grade VIN increased by 392% (n = 12 vs. 59) and of invasive vulvar cancer by 157% (n = 7 vs. 18). In the earlier cohort there were 7/126 (5%) women with invasive vulvar SCC under the age of 50 and, in the latter cohort, 18/112 (16%, P < .01).
  
  
  CONCLUSIONS
  Over the past decade a striking increase occurred in the incidence of VIN and an increase in invasive vulvar SCC in young women.
authors.affiliation: Department of Gynecology and Obstetrics, University of Vienna, Austria. elmar.joura@akh-wien.ac.at
authors.forename: E A
authors.initials: EA
authors.lastname: Joura
authors.forename: A
authors.initials: A
authors.lastname: Lösch
authors.forename: M G
authors.initials: MG
authors.lastname: Haider-Angeler
authors.forename: G
authors.initials: G
authors.lastname: Breitenecker
authors.forename: S
authors.initials: S
authors.lastname: Leodolter
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D014846:Vulvar Neoplasms / Q000453:epidemiology* / Q000473:pathology