title: Developmental plasticity in children: the role of biological risk, development, time, and reserve.
abstract: Older views of the functional developmental plasticity of the developing central nervous system (CNS) focused on the protective effect of a young age at the time of insult. In these views, a younger rather than an older age at onset was thought to produce fewer and/or less severe symptoms and a more rapid recovery. More recently, neurobehavioral outcome has been studied in a variety of medical conditions that affect the developing CNS; at the same time, new investigative techniques, such as brain imaging, have elucidated the biological basis of structural and functional brain plasticity. In consequence of a better understanding of the structural and functional consequences of developmental CNS insults, a body of research has emerged that is shaping a new view of functional developmental plasticity, in which neurobehavioral outcome is set by the biological risk associated with a medical condition and moderated by age and development, the time since onset of the condition, and the reserve available within the child, family, school, and community.
authors.affiliation: Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada. mdennis@sickkids.on.ca
authors.forename: M
authors.initials: M
authors.lastname: Dennis
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology; D001921:Brain / Q000502:physiology*; D002648:Child; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009473:Neuronal Plasticity / Q000502:physiology*; D012307:Risk Factors