[The role of peptides in the cholinergic and adrenergic mechanisms of the regulation of gastric secretion].
With using pharmacological analysis of stimulation or blockage of enterocytes cholin- or adrenergic receptors chronic experiments on dogs with gastric fistulas were carried out to study the influence of peptides on gastric acid secretion stimulated by pentagastrin or histamine. The different peptides (met- and leu-enkephalins, substance P, angiotensins I and II, oxytocin, pentagastrin) and internal secretion hormones (insulin, glucagon) were infused parenterally under the stimulated gastric secretion. It is proposed the model of the peripheral link of neurohumoral regulation of gastric acid secretion in the stomach.
Korshak
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OL
Petro Bogach Research Institute of Physiology, Taras Shevchenko Kiev University.
Kotsiuba
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VL
D000704:Analysis of Variance; D000818:Animals; D004285:Dogs; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D011941:Receptors, Adrenergic / Q000187:drug effects* / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical
D010455:Peptides; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic