Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila.
Heparan sulfate proteoglycans (HSPGs) are associated with the cell surface and covalently linked to a small number of long unbranched chains of repeating disaccharides. Numerous biochemical studies of these extracellular matrix molecules have implicated them in a variety of biological phenomena, in particular cell-cell interactions. Recent genetic studies in Drosophila have begun to clarify the function of HSPGs in vivo and recent findings have implicated HSPGs in Wnt, Hedgehog, fibroblast growth factor and transforming growth factor-beta signaling pathways during development.
Baeg
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Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Perrimon
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D000818:Animals; D004330:Drosophila / Q000378:metabolism / Q000502:physiology*; D029721:Drosophila Proteins; D005346:Fibroblast Growth Factors / Q000378:metabolism; D053823:Hedgehog Proteins; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism*; D019476:Insect Proteins / Q000378:metabolism; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000502:physiology; D015398:Signal Transduction; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019812:Heparan Sulfate Proteoglycans; D019476:Insect Proteins; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C074622:wg protein, Drosophila; C077245:hh protein, Drosophila; D005346:Fibroblast Growth Factors