Molecular screening for colon cancer detection.
Screening for colorectal cancer is a widely debated issue. Faecal occult blood testing is, at present, the only single test available which is applicable to large populations. However, progress in the definition of genetic alterations in the aetiopathogenesis both of sporadic and hereditary colorectal cancer have made it possible to set up molecular methods for identifying subjects with colorectal cancer or who are at risk of developing it. The target genes involved and the source of genomic material to be studied are different for sporadic and hereditary conditions and determine the type of test to use.
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Department of Internal Medicine, University of Modena, Italy.
D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D020732:Cytogenetic Analysis / Q000379:methods*; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D009857:Oncogenes / Q000235:genetics; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm