title: Fetal biometric parameters, twin type and birth weight difference. A longitudinal study.
abstract: OBJECTIVE
  To examine the relationship between twin type, divided by zygosity, chorionicity, and birth weight difference [more or less than 15% intertwin weight difference at delivery] on fetal biometric measurements, including biparietal diameter, transverse abdominal diameter, head and abdominal circumferences (AC) and head and abdominal areas, femur length (FL), transverse cerebellar diameter, cerebellar circumference and cerebellar area at 18, 23, 28 and 32 weeks of gestational age.
  
  
  METHODS
  A prospective and longitudinal study was done on 75 twin pairs that did not present the twin-twin transfusion syndrome (150 fetuses) divided into birth weight difference group I (<15%) and group II (>/=15%). The twin pairs were divided into three groups: dizygotic, monochorionic, and dichorionic-monozygotic. In each group the differences in various ultrasound indices were evaluated in reference to discordant growth or concordant growth.
  
  
  RESULTS
  In our sample, there were no monozygotic twin pairs with dichorionic placentation with a birth weight difference of more than 15%. Significant associations of group and gestational age were found in dizygotic and monochorionic twins. Intrapair differences were significantly higher in group II (>/=15%) than in group I (<15%) for all fetal parameters studied except for AC, abdominal area and all cerebellar parameters. The value of these discrepancies increased according to gestational age except for FL. Significant interactions between group and zygosity type indicated that intrapair FL differences were more associated with group in monochorionic twins, whereas intrapair transverse cerebellar diameter differences were more associated with group in dizygotic twins.
  
  
  CONCLUSIONS
  Our data show that most fetal biometric parameters are associated with birth weight discordancy. Abdominal area could be a relevant marker for twins with obstetric complications. Note that this is the first research that has studied a twin sample divided by both twin type and birth weight group.
authors.affiliation: Unité de Recherches d'Epidémiologie Génétique, INSERM U 155, Laboratoire d'Anthropologie Biologique, Université Paris VII, Tour 16, 3eétage, Case 7041, 2 Place Jussieu, 75005 05, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Charlemaine
authors.forename: M
authors.initials: M
authors.lastname: Duyme
authors.forename: Y
authors.initials: Y
authors.lastname: Ville
authors.forename: A
authors.initials: A
authors.lastname: Aurengo
authors.forename: R
authors.initials: R
authors.lastname: Tremblay
authors.forename: R
authors.initials: R
authors.lastname: Frydman
authors.forename: J C
authors.initials: JC
authors.lastname: Pons
mesh_terms: D001699:Biometry; D001724:Birth Weight; D002531:Cerebellum / Q000196:embryology; D005314:Embryonic and Fetal Development; D005260:Female; D005865:Gestational Age; D006801:Humans; D008137:Longitudinal Studies; D011247:Pregnancy; D011446:Prospective Studies; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D016216:Ultrasonography, Prenatal