title: Molecular mode of action of the large clostridial cytotoxins.
authors.affiliation: Institut für Pharmakologie und Toxikologie, Universität Freiburg, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Just
authors.forename: F
authors.initials: F
authors.lastname: Hofmann
authors.forename: K
authors.initials: K
authors.lastname: Aktories
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002384:Catalysis; D003013:Clostridium / Q000737:chemistry / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D004768:Enterotoxins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005964:Glucosyltransferases / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006031:Glycosylation; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014532:Uridine Diphosphate Glucose / Q000378:metabolism; D020764:cdc42 GTP-Binding Protein / Q000037:antagonists & inhibitors / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D018631:ras Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; C075216:Clostridium novyi alpha-toxin; D004768:Enterotoxins; C072293:hemorrhagic toxin HT, Clostridium sordellii; C072292:lethal toxin LT, Clostridium sordellii; C041348:tcdA protein, Clostridium difficile; C031815:toxB protein, Clostridium difficile; D005964:Glucosyltransferases; D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins; D018631:ras Proteins; D020741:rho GTP-Binding Proteins; D014532:Uridine Diphosphate Glucose