Interleukin 18 (IL-18) levels in patients with sepsis.
IL-18 levels in the blood of 13 sepsis patients were assessed. The IL-18 values were significantly correlated with their Acute Physiology and Chronic Health Evaluation (APACHE) II scores, and they were a good reflection of the severity of the disease. There was also a strong correlation between the IL-18 values and the patients' inflammatory cytokine levels. The results suggested strong involvement of IL-18 in the pathogenesis of sepsis.
Endo
S
S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Inada
K
K
Yamada
Y
Y
Wakabayashi
G
G
Ishikura
H
H
Tanaka
T
T
Sato
S
S
D018806:APACHE; D002056:Burns / Q000473:pathology; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D020382:Interleukin-18; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha