Changes in thermonociceptive thresholds and the role of enkephalinase A in homeostasis in morphine-tolerant rat offspring.
The dynamics of thermonociceptive thresholds as a marker of the state of the endogenous opioid system was studied in the offspring of morphine-tolerant rats. Significant, age-dependent increase in thermonociceptive thresholds and higher levels of enkephalinase A in structures of the endogenous antinociceptive system were observed in the offspring compared with the control. These findings attest to disturbances of the opioid system in the progeny of morphine-tolerant rats and confirm the key role of enkephalinase A in the maintenance of homeostasis disturbed by chronic prenatal morphine treatment.
Litvinova
S V
SV
Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University.
Aristova
V V
VV
Shulgovskii
V V
VV
Terebilina
N N
NN
Panchenko
L F
LF
D000818:Animals; D000831:Animals, Newborn; D004361:Drug Tolerance; D005260:Female; D006706:Homeostasis; D008297:Male; D008431:Maternal-Fetal Exchange; D009020:Morphine / Q000494:pharmacology*; D015260:Neprilysin / Q000502:physiology*; D017288:Pain Threshold; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D009020:Morphine; D015260:Neprilysin