Synthesis and characterization of a diruthenium-ibuprofenato complex comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex.
The ibuprofen complex of diruthenium(II,III) was prepared and characterized by electronic (UV-Vis) and vibrational (FTIR) spectroscopies and thermogravimetry. The copper(II)-ibuprofenato complex was prepared by a different route from that described in the literature. Both complexes were tested in vivo for anti-inflammatory activity. Oral administration of the two complexes inhibited development of carrageenin-induced edema in rats, this inhibition being similar to that observed for oral administration of the parent drug (free ibuprofen). However, gastric irritation was lower as compared to that of ibuprofen. Diruthenium-ibuprofenato exhibited a protective effect at light intensity ulceration while the copper-ibuprofenato complex was more effective in the protection of severe intensity ulceration.
Andrade
A
A
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, SP, Brazil.
Namora
S F
SF
Woisky
R G
RG
Wiezel
G
G
Najjar
R
R
Sertié
J A
JA
de Oliveira Silva
D
D
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006471:Gastrointestinal Hemorrhage / Q000473:pathology / Q000517:prevention & control / Q000523:psychology; D007052:Ibuprofen / Q000494:pharmacology; D007202:Indicators and Reagents; D008297:Male; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013272:Stomach Diseases / Q000473:pathology / Q000517:prevention & control / Q000523:psychology; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control / Q000523:psychology; D013315:Stress, Psychological / Q000503:physiopathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D009942:Organometallic Compounds; C418617:chlorotetrakis(ibuprofenato)diruthenium(II,III); C418618:tetrakis(ibuprofenato)dicopper(II); D002351:Carrageenan; D007052:Ibuprofen