1,5-benzodiazepine derivatives of 3-arylsydnones: synthesis and antimicrobial activity of 3-aryl-4-[2'-aryl-2',4',6',7'-tetrahydro-(1'H)-1',5'-benzodiazepine-4' -yl]sydnones.
The alpha-beta-unsaturated ketones of 3-arylsydnones (Ia-y) were treated with 1,2-phenylenediamine to obtain the 3-aryl-4-[2'-aryl- 2',4',6',7'-tetrahydro-(1'H)-1',5'-benzodiazepine-4'-yl]sydnones (IIa-y) in high yield. All the new compounds synthesised were screened for antibacterial and antifungal activities.
Kavali
J R
JR
Post-graduate Department of studies in Chemistry, Karnatak University, Dharwad, India.
Badami
B V
BV
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001569:Benzodiazepines / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013558:Sydnones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014481:United States
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013558:Sydnones; D001569:Benzodiazepines