title: Side-to-side isoperistaltic strictureplasty in extensive Crohn's disease: a prospective longitudinal study.
abstract: OBJECTIVE
  To report on the results of a prospective longitudinal study of a new bowel-sparing procedure (side-to-side isoperistaltic strictureplasty [SSIS]) in patients with extensive Crohn's disease.
  
  
  METHODS
  Between January 1992 and April 1999, the authors operated on 469 consecutive patients for Crohn's disease of the small bowel. Seventy-one patients (15.1%) underwent at least one strictureplasty; of these, 21 (4.5%; 12 men, 9 women; mean age 39) underwent an SSIS. The long-term changes occurring in the SSIS were studied radiographically, endoscopically, and histopathologically.
  
  
  RESULTS
  The indication for surgical intervention was symptomatic partial intestinal obstruction in each of the 21 patients. Fourteen SSISs were constructed in the jejunum, four in the ileum, and three with ileum overlapping colon. The average length of the SSIS was 24 cm. Performance of an SSIS instead of a resection resulted in preservation of an average of 17% of small bowel length. One patient suffered a postoperative gastrointestinal hemorrhage. All patients were discharged on oral feedings after a mean of 8 days. In all cases, SSIS resulted in resolution of the preoperative symptoms. With follow-up extending to 7.5 years in 20 patients (one patient died of unrelated causes), radiographic, endoscopic, and histopathologic examination of the SSIS suggests regression of previously active Crohn's disease.
  
  
  CONCLUSIONS
  SSIS is a safe and effective procedure in patients with extensive Crohn's disease. The authors' results provide radiographic, endoscopic, and histopathologic evidence that active Crohn's disease regresses at the site of the SSIS.
authors.affiliation: Departments of Surgery, Medicine, Radiology, and Pathology, University of Chicago, Chicago, Illinois 60637, USA. fmichela@surgery.bsd.uchicago.edu
authors.forename: F
authors.initials: F
authors.lastname: Michelassi
authors.forename: R D
authors.initials: RD
authors.lastname: Hurst
authors.forename: M
authors.initials: M
authors.lastname: Melis
authors.forename: M
authors.initials: M
authors.lastname: Rubin
authors.forename: R
authors.initials: R
authors.lastname: Cohen
authors.forename: A
authors.initials: A
authors.lastname: Gasparitis
authors.forename: S B
authors.initials: SB
authors.lastname: Hanauer
authors.forename: J
authors.initials: J
authors.lastname: Hart
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000473:pathology / Q000601:surgery*; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010528:Peristalsis / Q000502:physiology*; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology; D011446:Prospective Studies; D013536:Suture Techniques; D016896:Treatment Outcome