Proliferation and apoptosis within the oral mucosa "hemangiomas".
In the study the expression of Ki-67, p53, bcl-2 and apoptotic index in ten cases of lobular capillary hemangioma (LCH), ten of capillary hemangioma (CH), and five of epithelioid hemangioma (EH) was examined. The expression of Ki-67, p53 and bcl-2 did not differ significantly between each group of lesions. Instead, significant differences in apoptotic index between LCH and CH were found. The expression of bcl-2 was positively correlated with that of Ki-67 in LCH and CH group, but negatively correlated in the EH group. Our results confirm that LCH, EH and CH, which are histologically similar, are different in terms of proliferation/apoptosis balance. This reflects their different biology, and presumably pathogenesis.
Dyduch
G
G
Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Kraków.
Okoń
K
K
D017209:Apoptosis; D002455:Cell Division; D017789:Granuloma, Pyogenic / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018324:Hemangioma, Capillary / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D009059:Mouth Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53