title: Oncocytoma in melanocytoma of the spinal cord: case report.
abstract: OBJECTIVE
  Oncocytoma in the central nervous system is extremely unusual. The first reported example of oncocytoma in a melanocytoma of the spinal cord was successfully excised, and its pathological appearance is described.
  
  
  METHODS
  A 71-year-old woman presented with a 25-year history of back pain and myelographic evidence of a lumbar spinal cord mass. After declining surgical treatment for two decades, she elected eventually to have the mass excised. Preoperative magnetic resonance imaging revealed a large intraspinal mass that spanned spinal levels L3 through S1.
  
  
  METHODS
  The mass was excised en bloc through posterior laminectomies, and histopathological analysis revealed a benign neoplasm composed predominantly of monotonous sheets of plump oncocytes. Electron microscopy confirmed that the cytoplasm of the oncocytes was packed full of mitochondria. Focal areas of the tumor contained spindle cells, with abundant intracytoplasmic granular deposits of brown melanin pigment that contained melanosomes. Positive Fontana-Masson, HMB-45, and S-100 staining confirmed the final diagnosis of melanocytoma, oncocytic variant.
  
  
  CONCLUSIONS
  The first reported case of oncocytoma arising in spinal melanocytoma is described. After surgical excision, the patient recovered completely and has remained free of symptoms for 4 years.
authors.affiliation: Department of Pathology, University of Texas Medical Branch, Galveston 77555-0785, USA. bgelman@utmb.edu
authors.forename: B B
authors.initials: BB
authors.lastname: Gelman
authors.forename: T T
authors.initials: TT
authors.lastname: Trier
authors.forename: G
authors.initials: G
authors.lastname: Chaljub
authors.forename: J
authors.initials: J
authors.lastname: Borokowski
authors.forename: H J
authors.initials: HJ
authors.lastname: Nauta
mesh_terms: D018249:Adenoma, Oxyphilic / Q000473:pathology / Q000601:surgery*; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D009508:Nevus, Pigmented / Q000473:pathology / Q000601:surgery*; D012447:Sacrum; D013116:Spinal Cord / Q000473:pathology / Q000601:surgery; D013120:Spinal Cord Neoplasms / Q000473:pathology / Q000601:surgery*