Nitric oxide and the gut.
Nitric oxide (NO) has been implicated as a modulator of blood flow, motility, electrolyte and water transport, and the function of endothelial cells, platelets, mast cells, and macrophages within the digestive system. In addition, a number of reports have demonstrated that NO possesses potent anti-inflammatory properties, whereas results from an equally impressive number of studies suggest that NO may promote inflammation-induced cell and tissue dysfunction. Consideration of the physiologic chemistry of NO and its interaction with molecular oxygen and/or superoxide may allow us to identify which of the NO-dependent reactions are important in modulating physiologic and pathophysiologic responses in the gut.
Jourd'heuil
D
D
Vascular Biology Research Group, MS 113, Department of Physiology and Cell Biology, Albany Medical College, 47 New Scotland Avenue (MC 8), Albany, NY 12208, USA.
Grisham
M B
MB
Granger
D N
DN
D001692:Biological Transport / Q000502:physiology; D001783:Blood Flow Velocity; D004068:Digestive System Physiological Phenomena; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D012680:Sensitivity and Specificity
D016166:Free Radical Scavengers; D009569:Nitric Oxide