title: Approaches to the fully functionalized DEF ring system of ristocetin A via highly selective ruthenium-promoted S(N)Ar reaction.
abstract: Ruthenium-promoted intramolecular S(N)Ar reaction has allowed the construction of the fully functionalized 16-membered DEF macrocycle 4 of ristocetin A that incorporates the required arylglycine and arylserine residues as the F and E ring, respectively.
authors.affiliation: Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA. ajp4@po.cwru.edu
authors.forename: A J
authors.initials: AJ
authors.lastname: Pearson
authors.forename: J N
authors.initials: JN
authors.lastname: Heo
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D012310:Ristocetin / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry*; D017334:Teicoplanin / Q000138:chemical synthesis; D014640:Vancomycin / Q000138:chemical synthesis
chemical_list: D000900:Anti-Bacterial Agents; D012310:Ristocetin; C016719:ristocetin A; D017334:Teicoplanin; D014640:Vancomycin; D012428:Ruthenium