Administration of melatonin in drinking water promotes the phase advance of light-dark cycle in senescence-accelerated mice, SAMR1 but not SAMP8.
We analyzed effects of aging on behavioral rhythms in the mouse showing senescence acceleration, SAMP8 strains. The free-running rhythms had longer free-running periods (tau) in SAMP8 than in the control strain (SAMR1). Drinking of melatonin promoted the adaptation to advanced LD in SAMR1 but not in SAMP8, although both strains exhibited melatonin MT1 and MT2 receptors. The present results suggest that melatonin promotes the adaptation to advanced LD cycles in normal aging mice.
Asai
M
M
Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, 359-1192, Saitama, Japan.
Ikeda
M
M
Akiyama
M
M
Oshima
I
I
Shibata
S
S
D000222:Adaptation, Physiological / Q000187:drug effects*; D019588:Aging, Premature / Q000235:genetics / Q000503:physiopathology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects; D003623:Dark Adaptation / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000008:administration & dosage* / Q000494:pharmacology; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D009043:Motor Activity / Q000187:drug effects; D017440:Photoperiod; D012333:RNA, Messenger / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D044094:Receptors, Melatonin; D013045:Species Specificity; D014867:Water
D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D044094:Receptors, Melatonin; D014867:Water; D008550:Melatonin