title: A spectroscopic and crystallographic study of polymorphism in an aza-steroid.
abstract: The crystal structures of two enantiotropic polymorphs of the aza-steroid finasteride (N-(1-1-di-methylethyl)-3-oxo-4-aza-5 alpha-and rost-1-ene-17 beta-carboxam ide ) have been determined. The solid-state nuclear magnetic resonance spectra, infrared spectra, and physical property data of these two polymorphs are discussed in relation to both their solid-state structures and hydrogen-bonding networks.
authors.affiliation: Merck Research Laboratories, 126 E. Lincoln Avenue, Rahway, New Jersey 07065-0900, USA. robert_wenslow@merck.com
authors.forename: R M
authors.initials: RM
authors.lastname: Wenslow
authors.forename: M W
authors.initials: MW
authors.lastname: Baum
authors.forename: R G
authors.initials: RG
authors.lastname: Ball
authors.forename: J A
authors.initials: JA
authors.lastname: McCauley
authors.forename: R J
authors.initials: RJ
authors.lastname: Varsolona
mesh_terms: D001372:Aza Compounds / Q000737:chemistry*; D003461:Crystallography; D004791:Enzyme Inhibitors / Q000737:chemistry*; D018120:Finasteride / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
chemical_list: D001372:Aza Compounds; D004791:Enzyme Inhibitors; D018120:Finasteride