The Epidural and Intrathecal Administration of Ketamine.
An overview of the spinal administration of ketamine is presented. Ketamine acts as a noncompetitive antagonist of the NMDA receptor Ca(++ channel pore. This effect provides interesting possibilities in pain therapy. However, there are still contrasting results that seem to be due to a lack of comparative controlled studies. The presence of systemic and neurotoxic effects presently limits clinical use).
Beltrutti
DP
Servizio di Anestesia e Rianimazione, Centro del Dolore, Ospedale S. Spirito, Via Vittorio Emanuele, 3, 12042 Bra, Italy. beltrutti@gem.it
Trompeo
AC
Di Santo S