title: The effect of acute insulin-like growth factor-II administration on glucose metabolism in the rat.
abstract: The in vivo effects of the insulin-like growth factor-II (IGF-II) on glucose metabolism is not yet well defined. To assess the acute effect of IGF-II administration on whole body glucose utilization and hepatic glucose production, we used the well-established euglycemic clamp technique and compared the effects in awake cannulated rats with those of insulin. Each animal underwent several 90-min euglycemic studies, alternating between IGF-II and insulin. Following IGF-II infusion, tissue glucose uptake was increased to 9.8 +/- 0.6 mg/kg/min (mean +/- SEM), which represented only 14% of the effect of insulin, despite the molar plasma concentration ratio of insulin: IGF-2 being 1:460. IGF-II and insulin infusion reduced hepatic glucose output by 49 and 75%, respectively. Thus, IGF-II, administered acutely, affects glucose homeostasis in a manner very similar to insulin, probably via the insulin receptors, although with significantly lower potency.
authors.affiliation: Institute of Endocrinology, Diabetes and Metabolism, Rambam Medical Center and B. Rappaport Faculty of Medicine, Technion Haifa, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Burvin
authors.forename: D
authors.initials: D
authors.lastname: LeRoith
authors.forename: H
authors.initials: H
authors.lastname: Harel
authors.forename: M
authors.initials: M
authors.lastname: Zloczower
authors.forename: M
authors.initials: M
authors.lastname: Marbach
authors.forename: E
authors.initials: E
authors.lastname: Karnieli
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism*; D015309:Glucose Clamp Technique; D007003:Hypoglycemia / Q000139:chemically induced; D007335:Insulin-Like Growth Factor II / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007335:Insulin-Like Growth Factor II; D005947:Glucose