Bioactive carotanes from Trichoderma virens.
Four new metabolites with carotane skeletons, trichocaranes A (1), B (2), C (3), and D (4), were isolated from Trichoderma virens and their structures established by the interpretation of NMR and mass spectroscopic data. The trichocaranes significantly inhibited the growth of etiolated wheat coleoptiles: 40% at 10(-4) M with 1 and 2 and 86% at 10(-3) M with 3.
Macías
F A
FA
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Apdo. 40, 11510-Puerto Real, Cádiz, Spain. famacias@uca.es
Varela
R M
RM
Simonet
A M
AM
Cutler
H G
HG
Cutler
S J
SJ
Eden
M A
MA
Hill
R A
RA
D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014242:Trichoderma / Q000737:chemistry*; D014908:Triticum / Q000187:drug effects* / Q000254:growth & development
D012717:Sesquiterpenes