title: A comparison of inverse-detected heteronuclear NMR performance: conventional vs cryogenic microprobe performance.
abstract: We report a comparison of the results obtained at 500 MHz for heteronuclear shift correlation (HSQC) experiments with very small natural product samples using conventional and cryogenically cooled 3 mm NMR probes. The cryo probe affords a 12- to 16-fold reduction in data acquisition time for a comparable signal-to-noise ratio.
authors.affiliation: Rapid Structure Characterization Group, Pharmaceutical Development, Pharmacia Corporation, Kalamazoo, Michigan 49001-0199, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Russell
authors.forename: C E
authors.initials: CE
authors.lastname: Hadden
authors.forename: G E
authors.initials: GE
authors.lastname: Martin
authors.forename: A A
authors.initials: AA
authors.lastname: Gibson
authors.forename: A P
authors.initials: AP
authors.lastname: Zens
authors.forename: J L
authors.initials: JL
authors.lastname: Carolan
mesh_terms: D003080:Cold Temperature; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D011042:Poisons / Q000737:chemistry*; D013331:Strychnine / Q000737:chemistry*
chemical_list: D011042:Poisons; D013331:Strychnine