[The immunomodulating properties of translam].
Effect of translam--beta-1,3;1,6-D-glucan on some of naturally occurring host protective mechanisms was investigated. It was shown that translam has potent biological activity: it has preventive effect on experimental bacterial infections, it stimulates absorbtion and digestion activity of mononuclear phagocytes, it effects on humoral and cell immunity. Translam had mitogenic activity.
Ivanushko
L A
LA
Research Institute of Epidemiology and Microbiology, Siberian Branch, Russian Academy of Medical Sciences, Vladivostok.
Besednova
N N
NN
Zaporozhets
T S
TS
Zviagintseva
T N
TN
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000401:mortality; D005936:Glucans / Q000494:pharmacology* / Q000627:therapeutic use; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D007795:Laminaria; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D015012:Yersinia pseudotuberculosis Infections / Q000188:drug therapy / Q000401:mortality
D000276:Adjuvants, Immunologic; D005936:Glucans; D008934:Mitogens; C033671:epiglucan