Blastoschizomyces capitatus infection in acute leukemia patients.
Blastoschizomyces capitatus (BC), a filamentous fungus of genus Trichosporum, is as an important opportunistic pathogen in the compromised host. Within the past 10 years, 47 cases of BC infection have been published. Most of the patients had acute leukemia (AL) or related disorders and had received chemotherapy treatment. Due to BC's resistance to currently used antifungal agents, this infection represents a therapeutic challenge and serious complication in the treatment of hematology malignancies. Here we report our experience with BC infection in four patients with acute leukemia or related disorders.
Pérez-Sanchez
I
I
Department of Hematology, University General Hospital Gregorio Marañón, Madrid, Spain.
Anguita
J
J
Martín-Rabadan
P
P
Muñoz
P
P
Serrano
D
D
Escudero
A
A
Pintado
T
T
D000208:Acute Disease; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007938:Leukemia / Q000150:complications / Q000188:drug therapy / Q000469:parasitology*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000139:chemically induced / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced; D014250:Trichosporon
D000935:Antifungal Agents; D000666:Amphotericin B