Radiotherapy for pediatric genitourinary tumors. Its role and long-term consequences.
Radiation therapy has traditionally played a major role in the treatment of pediatric genitourinary malignancies. In particular, Wilms' tumor, rhabdomyosarcoma, and neuroblastoma often include radiotherapy in the local control phase of treatment. Recently, clinical trials have focused on decreasing the toxicity of radiotherapy through dose modifications and conformal field arrangements. Radiotherapy will continue to be a major treatment modality for this patient group if technologic advances in radiation delivery continue to increase efficacy without comorbidities.
Ludin
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Department of Radiation Oncology, MetroHealth Medical Center, Cleveland, Ohio, USA. aludin@metrohealth.org
Macklis
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D002648:Child; D005260:Female; D006801:Humans; D009447:Neuroblastoma / Q000532:radiotherapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011256:Pregnancy Outcome; D011878:Radiotherapy / Q000009:adverse effects; D012208:Rhabdomyosarcoma / Q000401:mortality / Q000532:radiotherapy; D016019:Survival Analysis; D016896:Treatment Outcome; D014565:Urogenital Neoplasms / Q000532:radiotherapy*; D009396:Wilms Tumor / Q000532:radiotherapy