Thyroid hormones and treatment of obesity.
Thyroid hormones have important thermogenic function. Nevertheless, thyroid dysfunctions are often associated with minor changes in body weight and fat mass. On the other hand, both overfeeding and fasting have important effects on iodothyronine metabolism and regulation of deiodinase activity. Although under debate, there are clinical and theoretical reasons to administer low-dose thyroid hormones (T3) in selected obese patients. This short review deals with both pathophysiological and clinical aspects of thyroid hormone used in the therapy of obesity.
Krotkiewski
M
M
Department of Medical Rehabilitation, Sahlgren's University Hospital, Gothenburg, Sweden. mpab@algonet.se
D001833:Body Temperature Regulation; D006801:Humans; D009765:Obesity / Q000178:diet therapy / Q000188:drug therapy*; D013963:Thyroid Hormones / Q000627:therapeutic use*; D014284:Triiodothyronine / Q000008:administration & dosage / Q000627:therapeutic use; D015431:Weight Loss
D013963:Thyroid Hormones; D014284:Triiodothyronine