Bartter syndrome and focal segmental glomerulosclerosis: a possible link between two diseases.
We describe a patient with signs and symptoms of classic Bartter syndrome. The patient tested negative for all known genetic abnormalities associated with this tubular disorder. Proteinuria was found within 1 year after the diagnosis of Bartter syndrome. A renal biopsy performed 6 months later, when her kidney function was normal, revealed focal segmental glomerulosclerosis (FSGS). We propose a link between stimulation of the renin-angiotensin system and sclerotic changes in the glomerulus. This lesion may explain previous reports of kidney failure in patients with Bartter syndrome.
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I H
IH
Division of Pediatric Nephrology, Schneider Children's Hospital of the North Shore-LIJ Health System, Albert Einstein College of Medicine, New Hyde Park, NY 11040-1432, USA.
Frank
R
R
Gauthier
B G
BG
Valderrama
E
E
Simon
D B
DB
Lifton
R P
RP
Trachtman
H
H
D000293:Adolescent; D001477:Bartter Syndrome / Q000150:complications* / Q000473:pathology / Q000652:urine; D001706:Biopsy; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D011507:Proteinuria / Q000209:etiology