title: Diagnostic accuracy of sonography and combined sonographic assessment and sonographically guided cytology in nonpalpable solid breast lesions.
abstract: OBJECTIVE
  The aim of this study was to assess the diagnostic accuracy of sonography alone and combined sonographic assessment and sonographically guided fine-needle aspiration cytology in solid, nonpalpable lesions of the breast.
  
  
  METHODS
  We retrospectively evaluated the sonograms from a series of 174 consecutive nonpalpable masses that were cytologically diagnosed using fine-needle aspiration under sonographic guidance and then histologically verified through surgical excision. We examined the relationships between the findings from sonography, combined sonographic assessment and cytopathology, and histology.
  
  
  RESULTS
  Histologically, 95 lesions (55%) were malignant and 79 (45%) were benign. The overall sensitivity of sonography alone for diagnosing cancer was 98. 9% (94 of 95 lesions), and the specificity was 45.6% (36 of 79 lesions). One (3%) of 37 masses considered at sonography to be benign was correctly diagnosed on cytologic examination to be cancer. By establishing the benign status of 11 of 13 masses that were indeterminate at sonography, cytology increased the specificity of the combined method (to 56.3%). Cytology appropriately suspected or confirmed malignancy in 79 (84%) of 94 carcinomas considered at sonography to be suspicious or malignant.
  
  
  CONCLUSIONS
  In this study, sonography alone demonstrated a high sensitivity but limited specificity in evaluating nonpalpable breast masses. The addition of sonographically guided cytology substantially increased the specificity of the combined method without compromising sensitivity.
authors.affiliation: Department of Radiology, Institut Curie, 26 Rue d'Ulm, 75231 Paris Cedex 05, France.
authors.forename: F
authors.initials: F
authors.lastname: Thibault
authors.forename: M
authors.initials: M
authors.lastname: Meunier
authors.forename: J
authors.initials: J
authors.lastname: Klijanienko
authors.forename: C
authors.initials: C
authors.lastname: El Khoury
authors.forename: C
authors.initials: C
authors.lastname: Nos
authors.forename: A
authors.initials: A
authors.lastname: Vincent-Salomon
authors.forename: B
authors.initials: B
authors.lastname: Asselain
authors.forename: S
authors.initials: S
authors.lastname: Neuenschwander
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000295:instrumentation*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D010173:Palpation; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000379:methods*