Experimental models of Reye's syndrome.
Intraperitoneal administration of 4-pentenoic acid (20 mg/kg/day for seven days or ten doses of 50 mg/kg with 4 h intervals) or acetylsalicylic acid (50 mg/kg 1 hour after single pyrogenal injection) to rats reproduced metabolic disorders characteristic of Reye's syndrome: hyperenzymemia, hyperbilirubinemia, decreased levels of ketone bodies and urea, hypoglycemia, hypoproteinemia, accumulation of ammonia and phenol, and acidosis. Necroses and microvesicular steatosis were found in the liver.
Saratikov
A S
AS
Department of Pharmacology, Medico-Biological Faculty, Siberian Medical University, Tomsk.
Vengerovskii
A I
AI
Arbuzov
A G
AG
Chuchalin
V S
VS
Chervyakova
M B
MB
Sukhodolo
I V
IV
D000818:Animals; D004195:Disease Models, Animal; D051381:Rats; D012202:Reye Syndrome