[Parameters of hemodynamics and red cell redox-status in old patients with ischemic heart disease].
Red cell redox-status and hemodynamic changes were studied in 60 old patients with ischemic heart disease. The treatment consisted of standard therapy (ST), ST + amino acid composition (glutaminic acid, glycine, cysteine) or preductal (15, 30 and 15 patients, respectively). Glutathione levels, activity of glutathione-transferase, reductase, peroxidase, catalase, Cu-, Zn-superoxide dismutase, red cell levels of malonic dialdehyde, hemodynamic parameters according to echo-CG and ECG monitoring were estimated before the treatment and 20 days after it. Endogenic antioxidant defense/hemodynamic parameters correlation coefficients were calculated. Close correlations were not found. However, ST + amino acid composition demonstrated the weakest correlations between the antioxidant defense and hemodynamics, while ST + preductal produced the greatest number of correlations. It is suggested that amino acids promote search for the antioxidant system's optimum while ST + preductal promotes closer correlations between red cell redox status and hemodynamic parameters.
Zaslavskaia
R M
RM
Kalinina
E V
EV
Komissarova
I A
IA
Kelimberdieva
E S
ES
Teĭblium
M M
MM
D000368:Aged; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D003545:Cysteine / Q000097:blood / Q000627:therapeutic use; D015716:Electrocardiography, Ambulatory; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000097:blood / Q000627:therapeutic use; D005998:Glycine / Q000097:blood / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology*; D010084:Oxidation-Reduction; D011379:Prognosis; D014665:Vasodilator Agents / Q000627:therapeutic use
D000975:Antioxidants; D015415:Biomarkers; D014665:Vasodilator Agents; D005978:Glutathione; D003545:Cysteine; D005998:Glycine