A new approach to vaccination: polymorphic vaccines for RNA viruses.
Conventional vaccines consist of a very large number of virtually identical molecules. While these have been extremely effective for prevention against viral diseases, development of vaccines against rapidly changing pathogens such as human immunodeficiency virus (HIV) and hepatitis C virus has proved to be more difficult. We propose a new approach to vaccination against these rapidly mutating pathogens by the use of vaccines consisting of a set of highly polymorphic recombinant molecules.
Cohen
J I
JI
Medical Virology Section, Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, Maryland 20892, USA.
D016915:AIDS Vaccines / Q000235:genetics; D006678:HIV / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000235:genetics / Q000276:immunology; D006801:Humans; D008954:Models, Biological; D011110:Polymorphism, Genetic; D012328:RNA Viruses / Q000235:genetics* / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000235:genetics; D014761:Viral Hepatitis Vaccines / Q000235:genetics; D014765:Viral Vaccines / Q000235:genetics*
D016915:AIDS Vaccines; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines; D014765:Viral Vaccines