Effect of nitro derivatives on electromechanical coupling in ureteral smooth muscle cells.
Double sucrose gap experiments revealed differences in the effect of nitroglycerin and sodium nitroprusside on action potential and contraction of ureteral smooth muscle cells. Unlike sodium nitroprusside, nitroglycerin inhibited voltage-dependent Ca(2+) membrane permeability. It was concluded that cGMP-independent mechanisms of the effects of nitro derivative reflect the peculiarities of excitation-contraction coupling in smooth muscles.
Kovalev
I V
IV
Department of Biophysics, Siberian Medical University, Tomsk.
Popov
A G
AG
Panov
A A
AA
Borodin
Y L
YL
Kapilevich
L V
LV
Anfinogenova
Y D
YD
Baskakov
M B
MB
Medvedev
M A
MA
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology*; D005996:Nitroglycerin / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology*; D014599:Uterus / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D009599:Nitroprusside; D005996:Nitroglycerin