In vitro studies of insulin-like growth factor I and bone.
Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro.
Conover
C A
CA
Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA. Conover.Cheryl@Mayo.edu
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D002455:Cell Division; D002478:Cells, Cultured; D006801:Humans; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000378:metabolism; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000378:metabolism; D018969:Insulin-Like Growth Factor Binding Proteins / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000502:physiology; D008666:Metalloendopeptidases / Q000378:metabolism; D008954:Models, Biological; D010006:Osteoblasts / Q000378:metabolism; D014407:Tumor Cells, Cultured
D018974:Insulin-Like Growth Factor Binding Protein 4; D018975:Insulin-Like Growth Factor Binding Protein 5; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I; D008666:Metalloendopeptidases