title: Neonatal hypoxic-ischemic encephalopathy: detection with diffusion-weighted MR imaging.
abstract: OBJECTIVE
  Although diffusion-weighted imaging has been shown to be highly sensitive in detecting acute cerebral infarction in adults, its use in detecting neonatal hypoxic-ischemic encephalopathy (HIE) has not been fully assessed. We examined the ability of this technique to detect cerebral changes of acute neonatal HIE in different brain locations.
  
  
  METHODS
  Fifteen MR examinations were performed in 14 neonates with HIE (median age, 6.5 days; range, 2-11 days). Imaging comprised conventional T1-weighted, proton density-weighted, and T2-weighted sequences and echo-planar diffusion-weighted sequences. The location, extent, and image timing of ischemic damage on conventional and diffusion-weighted sequences and apparent diffusion coefficient (ADC) maps were compared.
  
  
  RESULTS
  Although conventional sequences showed cerebral changes consistent with ischemia on all examinations, diffusion-weighted imaging showed signal hyperintensity associated with decreased ADC values in only seven subjects (47%). All subjects with isolated cortical infarction on conventional sequences had corresponding hyperintensity on diffusion-weighted images and decreased ADC values, as compared with 14% of subjects with deep gray matter/perirolandic cortical damage. The timing of imaging did not significantly alter diffusion-weighted imaging findings.
  
  
  CONCLUSIONS
  Diffusion-weighted imaging, performed with the technical parameters in this study, may have a lower correlation with clinical evidence of HIE than does conventional MR imaging. The sensitivity of diffusion-weighted imaging in detecting neonatal HIE appears to be affected by the pattern of ischemic damage, with a lower sensitivity if the deep gray matter is affected as compared with isolated cerebral cortex involvement.
authors.affiliation: Division of Neuroradiology, Barrow Neurological Institute, St Joseph's Hospital and Medical Center, AZ 85013, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Forbes
authors.forename: J G
authors.initials: JG
authors.lastname: Pipe
authors.forename: R
authors.initials: R
authors.lastname: Bird
mesh_terms: D000375:Aging / Q000502:physiology; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis*; D002545:Brain Ischemia / Q000175:diagnosis*; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods*