title: Vasodilator effect of extract prepared from Uncariae ramulus on isolated rat aorta.
abstract: Uncariae ramulus et Uncus (URE) has a vasodilator effect. Its mechanism consists of not only endothelium-independent relaxation with Ca2+ channel blocking effect but also endothelium-dependent relaxation with nitric oxide. The active components are alkaloids and tannin contained in Uncariae ramulus et Uncus. They also show a superoxide dismutase-like effect and suppressed vasocontraction induced by xanthine and xanthine oxidase. These mechanisms may also influence vasodilatation by Uncariae ramulus et Uncus in vivo.
authors.affiliation: Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: I
authors.initials: I
authors.lastname: Sakakibara
authors.forename: Y
authors.initials: Y
authors.lastname: Shimada
authors.forename: Y
authors.initials: Y
authors.lastname: Kasahara
authors.forename: K
authors.initials: K
authors.lastname: Terasawa
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001011:Aorta / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D004365:Drugs, Chinese Herbal; D014665:Vasodilator Agents