title: Malignant odontogenic myxoma of the maxilla: case with cytogenetic confirmation.
abstract: An odontogenic myxoma of the maxilla with an aggressive clinical course is presented. The tumour arose in a 53-year-old patient, recurred two times after extended maxillectomy and ultimately caused the patient's death by uncontrollable local disease with infiltration of the cranial cavity. Microscopically, the tumour showed histological features of a low grade malignant myxosarcoma with cellular areas, enhanced mitotic activity and nuclear pleomorphism. Cytogenetic analysis revealed an unexpectedly aberrant hypertetraploid chromosome complement, that was considered as incompatible with the usual karyotypic patterns of benign tumours.
authors.affiliation: Department of Pathology, University of Saarland, Homburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Pahl
authors.forename: W
authors.initials: W
authors.lastname: Henn
authors.forename: T
authors.initials: T
authors.lastname: Binger
authors.forename: U
authors.initials: U
authors.lastname: Stein
authors.forename: K
authors.initials: K
authors.lastname: Remberger
mesh_terms: D006801:Humans; D007621:Karyotyping; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008441:Maxillary Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D008875:Middle Aged; D009232:Myxoma / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000601:surgery; D009808:Odontogenic Tumors / Q000175:diagnosis* / Q000601:surgery; D012086:Reoperation