[Kinins: their nature and their potential role in the cardiovascular effects of angiotensin-converting enzyme inhibitors].
The purpose of the present review dedicated to the kallikrein-kininogen-kinin system is to highlight the pathophysiological role of this complex system in kidney diseased patients. We will focus mainly on the nature of bradykinin and its active metabolite, des-Arg9-bradykinin. After the description of their properties, their metabolism and their receptors, we will show the recent evidence about the renal kallikrein-kinine system and its autocrin/paracrin role. This will allow to the nephrologist a better understanding of the role of these vasoactive peptides not only in the beneficial aspects, but also in the acute side-effects, of angiotensin-converting enzyme inhibitors.
Adam
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Faculté de pharmacie, Université de Montréal, Québec, Canada. adama@pharm.umontreal.ca
Blais
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C
Loute
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G
D000804:Angiotensin II / Q000502:physiology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D016234:Kallikrein-Kinin System / Q000187:drug effects / Q000502:physiology*; D007668:Kidney / Q000378:metabolism; D007674:Kidney Diseases / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011914:Rats, Inbred BN; D020303:Rats, Inbred Dahl; D018002:Receptors, Bradykinin / Q000187:drug effects / Q000502:physiology; D014666:Vasomotor System / Q000503:physiopathology
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D018002:Receptors, Bradykinin; D000804:Angiotensin II; C024626:bradykinin, des-Arg(9)-; D001920:Bradykinin