Patients with active relapsing-remitting multiple sclerosis synthesize antibodies recognizing oligodendrocyte progenitor cell surface protein: implications for remyelination.
In multiple sclerosis (MS), remyelination of demyelinated lesions diminishes with disease progression for unknown reasons. Oligodendrocyte progenitor cells contribute to remyelination; however, antibodies specific for oligodendrocyte progenitor antigens could block remyelination by eliminating or impeding these cells. In myelinating cultures, cell lysis with antibody recognizing a progenitor cell-specific surface glycoprotein (AN2) suppressed the synthesis of myelin proteins. Cerebrospinal fluid from patients with relapsing-remitting active MS contains antibodies against AN2, whereas cerebrospinal fluid from patients with nonactive disease does not. This is the first report describing antibodies in MS against a progenitor cell-specific antigen that may contribute to the development and progression of chronically demyelinated lesions.
Niehaus
A
A
Department of Neurobiology, University of Heidelberg, Germany.
Shi
J
J
Grzenkowski
M
M
Diers-Fenger
M
M
Archelos
J
J
Hartung
H P
HP
Toyka
K
K
Brück
W
W
Trotter
J
J
D000328:Adult; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D051379:Mice; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology* / Q000378:metabolism*; D009186:Myelin Sheath / Q000276:immunology / Q000378:metabolism*; D009413:Nerve Fibers, Myelinated / Q000276:immunology / Q000378:metabolism*; D009474:Neurons / Q000276:immunology / Q000378:metabolism*; D009836:Oligodendroglia / Q000276:immunology / Q000378:metabolism*
D000906:Antibodies