title: From the analysis of protein complexes to proteome-wide linkage maps.
abstract: Recent advances in genomics have led to the accumulation of an unprecedented amount of data about genes. Proteins, not genes, however, sustain function. The traditional approach to protein function analysis has been the design of smart genetic assays and powerful purification protocols to address very specific questions concerning cellular mechanisms. Lately, a number of proteome-wide functional strategies have emerged, giving rise to a new field in biology, proteomics, that addresses the biology of a cell as a whole.
authors.affiliation: Hybrigenics, Paris, France. plegrain@hybrigenics.fr
authors.forename: P
authors.initials: P
authors.lastname: Legrain
authors.forename: J L
authors.initials: JL
authors.lastname: Jestin
authors.forename: V
authors.initials: V
authors.lastname: Schächter
mesh_terms: D008967:Molecular Biology / Q000379:methods* / Q000639:trends; D009154:Mutation; D019151:Peptide Library; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic; D020798:Two-Hybrid System Techniques
chemical_list: D019151:Peptide Library; D011506:Proteins