HIV-1 genotypes in peripheral blood monocytes.
CD4+ T cells and tissue macrophages are well defined as the major targets for human immunodeficiency virus type 1 (HIV-1) infection and replication, and their infection accounts for many aspects of HIV-1 pathogenesis in vivo. HIV-1 genotype and phenotype in monocytes and their potential roles in pathogenicity in vivo remain unknown. Herein is an overview of our initial work on HIV-1 genotype in purified CD14+ monocytes isolated longitudinally during the course of infection starting from the time of infection. Our data provide evidence for HIV-1 evolution in monocytes and their role as a reservoir of HIV-1 in vivo. A better understanding of HIV-1 in monocytes may greatly help the development of new therapeutic strategies for HIV-1 infection.
Zhu
T
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Department of Laboratory Medicine, University of Washington, Seattle 98195, USA. tzhu@u.washington.edu
D000595:Amino Acid Sequence; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D005838:Genotype; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000097:blood / Q000235:genetics / Q000821:virology; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000097:blood; D008969:Molecular Sequence Data; D009000:Monocytes / Q000276:immunology / Q000821:virology*; D017386:Sequence Homology, Amino Acid
D015699:HIV Envelope Protein gp120; D018950:Lipopolysaccharide Receptors