[Effect of exogenous and endogenous nitrosation factors on formation of N-nitrosodimethylamine in rats depending on the status of purine catabolism].
Nitrogen dioxide's rats' inhalations with injections per os of pyrazole, amidopyrine and sodium nitrite lead to considerable increasing of endogenic N-nitrosodimethylamine formation, which had been determined by system gas chromatograph-thermal energetic analyser. This increasing essentially didn't depend on the rats' immunisation by vaccine BCG, which leads to the intensification of NO synthesis by peritoneal macrophages and others manifestations of their metabolic activation: increasing of creatine kinase and adenosine desaminase activities. It hadn't been brought to light the obvious dependent between changes of xanthine oxidase and xanthine dehydrogenase activities in the liver and blood serum and intensification of lipids peroxidation and also the amount of N-nitrosodimethylamine in the rats in the conditions of endogenic and exogenic nitrosation factors' influence.
Smerdova
L N
LN
L.I. Medved Institute of Ecohygiene and Toxicology, Kyiv.
Kishko
T O
TO
Glavin
A A
AA
Rubenchik
B L
BL
Dmitrenko
N P
NP
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D002849:Chromatography, Gas; D004128:Dimethylnitrosamine / Q000378:metabolism*; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D015538:Nitrosation; D011687:Purines / Q000378:metabolism*; D051381:Rats; D014968:Xanthine Dehydrogenase / Q000097:blood / Q000378:metabolism; D014969:Xanthine Oxidase / Q000097:blood / Q000378:metabolism
D001500:BCG Vaccine; D011687:Purines; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase; D004128:Dimethylnitrosamine