[The effect of serotonin on the healing of an experimental stomach ulcer following vagotomy].
On the model of gastric ulcer induced by stress with subsequent trunk vagotomy in rats it is shown that exogenic serotonin induces increased concentrations of serotonin in the gastric tissues, among them in the region of ulcer's defect, decreased amounts of histamine and increased serotonin-histamine indexes, and also promotes calming down of inflammatory phenomena and optimization of reparative processes in the region of ulcer.
Klymenko
M O
MO
Kharkov State Medical University, Ministry of Public Health of Ukraine.
Lupal'tsov
V I
VI
Iahniuk
A I
AI
Tatarko
S V
SV
D000272:Adipates / Q000627:therapeutic use*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006632:Histamine / Q000032:analysis; D008297:Male; D011708:Pylorus / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000031:analogs & derivatives* / Q000032:analysis / Q000627:therapeutic use; D013270:Stomach / Q000737:chemistry / Q000187:drug effects; D013276:Stomach Ulcer / Q000378:metabolism / Q000628:therapy*; D013315:Stress, Psychological / Q000378:metabolism / Q000628:therapy*; D013997:Time Factors; D014628:Vagotomy; D014945:Wound Healing / Q000187:drug effects*
D000272:Adipates; D000897:Anti-Ulcer Agents; C059902:serotonin adipinate; D012701:Serotonin; D006632:Histamine