Persistent polyclonal B lymphocytosis: morphological, immunological, cytogenetic and molecular analysis of an Italian case.
We describe a case of persistent polyclonal B-cell lymphocytosis (PPBL) studied by morphological, immunological, cytogenetic and molecular analysis. PPBL is a rare lymphoproliferative disorder with an unclear natural history. Although a few cases of malignancies are observed during PPBL, this disorder is usually considered to be an indolent syndrome. A longer follow-up in a larger number of patients is needed in order to clarify the natural history of PPBL and its potential to transform into a malignancy. As PPBL is a rare disease, establishing an international PPBL registry could be the most effective way to understand the natural history of this disease and to discover its etiologic factors.
Tonelli
S
S
Dipartimento di Scienze Mediche, Oncologiche e Radiologiche, Università degli studi di Modena e Reggio Emilia, Policlinico, 5 degrees piano, 41100, Modena, Italy.
Vanzanelli
P
P
Sacchi
S
S
Fiorani
C
C
Castelli
I
I
Temperani
P
P
Bonacorsi
G
G
D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008218:Lymphocytosis / Q000235:genetics / Q000276:immunology / Q000473:pathology*