title: [Chemotherapy for metastatic or recurrent laryngeal cancer: tolerance and early results].
abstract: In the Head and Neck Cancer Department of Cancer Centre in Warsaw between 1994 and 1998 fifty three patients with recurrent or metastatic laryngeal cancer were treated with methotrexate-based chemotherapy. Chemotherapy protocol consist of methotrexate, vinblastine, 5-fluorouracil, bleomycin, cyclophosphamide and steroids used every two weeks. Before treatment, unresectable local recurrence was observed in 35 patient and distant secondaries in 18 others. Tolerance of treatment was acceptable. Partial regression of the tumor was obtained in 30% of patients. Improvement of the quality of life was observed in 66%. Presented program is an effective alternative to supportive treatment in patients with recurrent or metastatic laryngeal cancer.
authors.affiliation: Klinika Nowotworów Głowy i Szyi, Centrum Onkologii w Warszawie.
authors.forename: A
authors.initials: A
authors.lastname: Kawecki
authors.forename: B
authors.initials: B
authors.lastname: Jagielska
authors.forename: S
authors.initials: S
authors.lastname: Falkowski
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome