[A polymorphism study of the CYP19 gene in endometrial cancer patients].
A strong connection is known to exist between initiation/promotion of endometrial cancer and excess of estrogens. Therefore, participation of certain alleles of genetic polymorphisms in steroid biosynthesis or metabolism may be responsible for predisposition to the disease. The present study, comparing CYP19 (aromatase) gene polymorphism in 85 patients and 110 healthy females, pointed to a more frequent occurrence of relatively longer alleles (A6 and A7) of the CYP19 gene in the former group. Furthermore, precisely those genotypes co-occurred more frequently with elevated blood levels of estradiol and testosterone in postmenopausal patients. Hence, CYP19 gene polymorphism may be regarded as a factor of genetic risk for endometrial carcinoma.
Bershteĭn
L M
LM
N. N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Imianitov
E N
EN
Suspitsyn
E N
EN
Grigor'ev
M Iu
MIu
Sokolov
E P
EP
Togo
A V
AV
Khanson
K P
KP
Poroshina
T E
TE
Gamaiunova
V B
VB
Vasil'ev
D A
DA
Kovalevskiĭ
A Iu
AIu
Volkov
O N
ON
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001141:Aromatase / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000097:blood / Q000235:genetics*; D004958:Estradiol / Q000097:blood; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic / Q000235:genetics*; D017698:Postmenopause / Q000097:blood; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D004958:Estradiol; D001141:Aromatase