title: Suppression of furylfuramide-induced SOS response by acetophenones using Salmonella typhimurium TA1535/pSK1002 umu test.
abstract: The recently isolated paeonol (2-hydroxy-4-methoxyacetophenone), as one of the antimutagenic compounds from Discorea japonica, was used as a lead compound for detailed structure-activity relationship studies. Nine acetophenones (2-hydroxy-4-methoxy, 2-hydroxy-5-methoxy, 2-hydroxy-6-methoxy, 4-hydroxy-3-methoxy, o-methoxy, m-methoxy, p-methoxy, and 2,5-dimethoxyacetophenone and acetophenone) were investigated for their ability of suppression of furylfuramide-induced SOS response using Salmonella typhimurium TA1535/pSK1002 in the umu test, against the mutagen, 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (furylfuramide). The results showed that 2-hydroxy-6-methoxyacetophenone displayed the strongest activity (EC(50) = 0.6 micromol/mL), and a hydroxyl group at C-2 is necessary feature for acetophenone derivatives to show the suppressive effects of furylfuramide-induced SOS response.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan. miyazawa@pch.kindai.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Miyazawa
authors.forename: H
authors.initials: H
authors.lastname: Shimamura
authors.forename: S i
authors.initials: Si
authors.lastname: Nakamura
authors.forename: W
authors.initials: W
authors.lastname: Sugiura
mesh_terms: D000098:Acetophenones / Q000494:pharmacology*; D005668:Furylfuramide / Q000494:pharmacology*; D013014:SOS Response, Genetics; D012486:Salmonella typhimurium / Q000235:genetics*
chemical_list: D000098:Acetophenones; D005668:Furylfuramide; C038699:acetophenone