New antibacterial metabolites from the cyanobacterium Nostoc commune(EAWAG 122b).
Two new compounds, a diterpenoid and an anthraquinone, as well as an indane derivative, which is reported as a natural product for the first time, have been isolated from the cells of the cultured cyanobacterium Nostoc commune (EAWAG 122b) by means of bioguided isolation. The structures were determined by spectroscopic methods, mainly NMR, infrared spectroscopy, and mass spectrometry. All isolates exhibit antibacterial activity.
Jaki
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Department of Applied BioSiences, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, 8057 Zürich, Switzerland.
Heilmann
J
J
Sticher
O
O
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D000458:Cyanobacteria / Q000378:metabolism*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013057:Spectrum Analysis; D013212:Staphylococcus epidermidis / Q000187:drug effects
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D004224:Diterpenes