title: Bioactive sesquiterpenes from the basidiomycete Resupinatus leightonii.
abstract: 1(10),4-Germacradiene-2,6,12-triol (1), a new germacrane sesquiterpene, and 1,6-farnesadiene-3,10,11-triol (2), a known nerolidol derivative, were isolated from submerged cultures of the basidiomycete Resupinatus leightonii. Both compounds inhibited cAMP-induced appressorium formation in Magnaporthe grisea and showed cytotoxic activity. The structure of 1 was determined by NMR and mass spectroscopic methods.
authors.affiliation: Institute for Biotechnology and Drug Research (IBWF e.V.), D-67663 Kaiserslautern, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Eilbert
authors.forename: M
authors.initials: M
authors.lastname: Engler-Lohr
authors.forename: H
authors.initials: H
authors.lastname: Anke
authors.forename: O
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D020082:Magnaporthe / Q000187:drug effects; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013057:Spectrum Analysis
chemical_list: D012717:Sesquiterpenes