title: Genomics happens.
abstract: Cholera has been the scourge of humankind for centuries. Although most of the time Vibrio cholerae, the microbe that causes this disease, is a free-living organism inhabiting aquatic environments, it can invade human hosts causing severe diarrhea and often death. As DiRita explains in his Perspective, sequencing of the entire V. cholerae genome is revealing new facets of the pathogenesis of this dangerous microbe.
authors.affiliation: Department of Microbiology and Immunology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
authors.forename: V J
authors.initials: VJ
authors.lastname: DiRita
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D002771:Cholera / Q000453:epidemiology / Q000382:microbiology; D002772:Cholera Toxin / Q000235:genetics; D002876:Chromosomes, Bacterial / Q000235:genetics; D010450:Endopeptidases; D016680:Genome, Bacterial; D006801:Humans; D016366:Open Reading Frames; D017422:Sequence Analysis, DNA; D014734:Vibrio cholerae / Q000235:genetics* / Q000472:pathogenicity* / Q000502:physiology; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D002772:Cholera Toxin; D010450:Endopeptidases; C067127:prepilin peptidase protein, Bacteria