title: Relationship of seizure frequency to hippocampus volume and metabolism in temporal lobe epilepsy.
abstract: OBJECTIVE
  To examine the relationship between frequency of complex partial (CPS) and secondarily generalized tonic-clonic seizures (sGTCS) on hippocampal volume (HV) and temporal lobe metabolism.
  
  
  METHODS
  We performed volumetric magnetic resonance imaging (MRI) and positron emission tomography with 18fluorodeoxyglucose (18FDG-PET) in 32 patients with epilepsy. Temporal lobe foci were localized by ictal video-EEG.
  
  
  RESULTS
  We did not find any association between CPS frequency or lifetime number of sGTCS and HV or metabolism ipsilateral to electroencephalographic focus.
  
  
  CONCLUSIONS
  The progress of metabolic or pathologic abnormalities of temporal lobe epilepsy may not be altered by adequate seizure control. The presence of an epileptic focus might be associated with progressive neuronal injury even in clinically well-controlled patients.
authors.affiliation: Clinical Epilepsy Section, Epilepsy Research Branch, National Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892-1408, USA.
authors.forename: M V
authors.initials: MV
authors.lastname: Spanaki
authors.forename: L
authors.initials: L
authors.lastname: Kopylev
authors.forename: K
authors.initials: K
authors.lastname: Liow
authors.forename: C
authors.initials: C
authors.lastname: DeCarli
authors.forename: S
authors.initials: S
authors.lastname: Fazilat
authors.forename: W D
authors.initials: WD
authors.lastname: Gaillard
authors.forename: W H
authors.initials: WH
authors.lastname: Theodore
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004569:Electroencephalography / Q000706:statistics & numerical data; D017029:Epilepsy, Complex Partial / Q000175:diagnosis / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000033:anatomy & histology* / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D014055:Tomography, Emission-Computed / Q000706:statistics & numerical data*; D014743:Videotape Recording
chemical_list: D019788:Fluorodeoxyglucose F18