title: 7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.
abstract: The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
authors.affiliation: Celltech-Chiroscience Ltd, Abington, Cambridge, UK.
authors.forename: G
authors.initials: G
authors.lastname: Buckley
authors.forename: N
authors.initials: N
authors.lastname: Cooper
authors.forename: H J
authors.initials: HJ
authors.lastname: Dyke
authors.forename: F
authors.initials: F
authors.lastname: Galleway
authors.forename: L
authors.initials: L
authors.lastname: Gowers
authors.forename: J C
authors.initials: JC
authors.lastname: Gregory
authors.forename: D R
authors.initials: DR
authors.lastname: Hannah
authors.forename: A F
authors.initials: AF
authors.lastname: Haughan
authors.forename: P G
authors.initials: PG
authors.lastname: Hellewell
authors.forename: H J
authors.initials: HJ
authors.lastname: Kendall
authors.forename: C
authors.initials: C
authors.lastname: Lowe
authors.forename: R
authors.initials: R
authors.lastname: Maxey
authors.forename: J G
authors.initials: JG
authors.lastname: Montana
authors.forename: R
authors.initials: R
authors.lastname: Naylor
authors.forename: C L
authors.initials: CL
authors.lastname: Picken
authors.forename: K A
authors.initials: KA
authors.lastname: Runcie
authors.forename: V
authors.initials: V
authors.lastname: Sabin
authors.forename: B R
authors.initials: BR
authors.lastname: Tuladhar
authors.forename: J B
authors.initials: JB
authors.lastname: Warneck
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000284:Administration, Oral; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D001549:Benzamides / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology; D001572:Benzofurans / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004802:Eosinophilia / Q000188:drug therapy; D006168:Guinea Pigs; D020128:Inhibitory Concentration 50; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000009:adverse effects / Q000138:chemical synthesis / Q000494:pharmacology; D020889:Rolipram / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014839:Vomiting / Q000139:chemically induced
chemical_list: D001549:Benzamides; D001572:Benzofurans; D010726:Phosphodiesterase Inhibitors; D011725:Pyridines; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram; C087566:piclamilast