Pathophysiology of obesity hypertension.
Excess weight gain is a major cause of essential hypertension, and abnormal kidney function appears to be a cause as well as a consequence of obesity hypertension. Excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role in mediating increased blood pressure associated with weight gain. Activation of the renin-angiotensin and sympathetic nervous systems and physical compression of the kidneys appear to contribute to obesity-induced increases in sodium reabsorption and hypertension.
Hall
J E
JE
Department of Physiology & Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.
D005227:Fatty Acids / Q000378:metabolism; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D020738:Leptin / Q000502:physiology; D009318:Natriuresis / Q000502:physiology; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology*; D012084:Renin-Angiotensin System / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000503:physiopathology
D005227:Fatty Acids; D020738:Leptin; D012964:Sodium