Multidimensional assessment of differences in monoamine metabolism in C57BL/6 and BALB/c mice.
Monoamine metabolism in the hypothalamus and striatum of BALB/c and C57Bl/6 mice (intact and stressed in the open field test) was studied using single- and multidimensional statistical methods. It is suggested that the revealed difference in neurotransmitter metabolism is associated with genetically controlled behavior of these animals under conditions of emotional stress. The results of discriminant analysis suggest that the regulation of monoamine metabolism during emotional stress is genetically determined.
Seredenin
S B
SB
Department of Molecular Genetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Lapitskaya
A S
AS
Nadorov
S A
SA
Kudrin
V S
VS
Badyshtov
B A
BA
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000378:metabolism*; D008810:Mice, Inbred C57BL / Q000378:metabolism*; D015999:Multivariate Analysis; D013045:Species Specificity
D015306:Biogenic Monoamines