The L6 membrane proteins--a new four-transmembrane superfamily.
L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.
Wright
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MD
The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia. wright_m@wehi.edu.au
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D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000737:chemistry* / Q000235:genetics; D000954:Antigens, Surface / Q000737:chemistry*; D016208:Databases, Factual; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry*; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000235:genetics; D010802:Phylogeny; D010980:Platelet Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D060149:Tetraspanin 30; D059470:Tetraspanins
D015703:Antigens, CD; D000954:Antigens, Surface; C554586:CD63 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D010980:Platelet Membrane Glycoproteins; C111029:TM4SF5 protein, human; C512650:TSPAN2 protein, human; D060149:Tetraspanin 30; D059470:Tetraspanins; C074075:TM4SF1 protein, human