Acute megakaryocytic leukaemia with acquired polysomy 21 and translocation t(1;21).
Cytogenetic study of a young child with acute megakaryocytic leukaemia (AML-M7) has shown a karyotype with 49-50 chromosomes with one and two acquired extra chromosomes 21. Fluorescence in situ hybridization detected a minor clone with translocation t(1;21) and loss of a part of chromosome band 1p36. Trisomy and polysomy 21 are not uncommon in AML-M7. A more systematic search for chromosome 21 rearrangements in AML-M7 using FISH techniques is proposed.
Paulien
S
S
Institut de biologie et biochimie appliquée (IBBA), Université de Caen, Esplanade de la Paix, 14032 cedex, Caen, France.
Busson-Le Coniat
M
M
Berger
R
R
D001853:Bone Marrow / Q000473:pathology / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000235:genetics; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D020732:Cytogenetic Analysis; D004314:Down Syndrome; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007223:Infant; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*