Differential effects of inorganic lead on hippocampal long-term potentiation in young rats in vivo.
Tetanic stimulation at 50 Hz elicited long-term potentiation (LTP) in the hippocampal CA1 region of 28-day-old control animals. In contrast, no significant potentiation was seen following the same tetanus in animals chronically exposed to 1000 ppm of lead acetate during development. Gender differences were observed in animals exposed to 500 ppm of lead. In females, LTP was significantly attenuated, while in males the LTP was identical to that of controls.
Zaiser
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Department of Comparative Biosciences and the Environmental Toxicology Center, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706-1102, USA.
Miletic
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V
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D004558:Electric Stimulation; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012727:Sex Characteristics
D009942:Organometallic Compounds; C008261:lead acetate