Photodynamic therapy for corneal neovascularization using topically administered ATX-S10 (Na).
OBJECTIVE
We investigated the effect of photodynamic therapy (PDT) using topically administered ATX-S10(Na) on corneal neovascularization (CoNV).


METHODS
Rabbit eyes with induced CoNV were treated with ATX-S10(Na) eye drops (10 mg/mL) every 5 minutes, 5 to 25 times. Five to ninety minutes after topical administration, the CoNV were irradiated with a diode laser using a wavelength of 670 nm.


RESULTS
The CoNV were occluded fluorescein angiographically in 7 of 16 treated eyes. The eyes having occluded, CoNV were irradiated using fluence of 510-1019 J/cm2 within 20 minutes of eye-drop administration. However, the effect was more variable than what we found using systemic administration in our previous investigation.


CONCLUSIONS
Experimental CoNV was occluded by photodynamic therapy using topically administered ATX-S100(Na), suggesting this modality as a possible treatment for CoNV avoids the side effects found with systemic administration of the dye. Further efforts to improve the eye drops in terms of pH and osmotic pressure are needed to achieve increased dye accumulation.
Gohto
Y
Y
Department of Ophthalmology, Osaka City University Medical School, Osaka, Japan. yuko-go@med.osaka-cu.ac.jp
Obana
A
A
Kanai
M
M
Nagata
S
S
Miki
T
T
Nakajima
S
S
D000287:Administration, Topical; D000818:Animals; D003315:Cornea / Q000473:pathology; D016510:Corneal Neovascularization / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D016222:Fibroblast Growth Factor 2 / Q000633:toxicity; D005451:Fluorescein Angiography; D009883:Ophthalmic Solutions; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D011817:Rabbits
C117772:ATX S10Na(II); D009883:Ophthalmic Solutions; D017319:Photosensitizing Agents; D011166:Porphyrins; D016222:Fibroblast Growth Factor 2