title: Noninvasive measurement of cerebral blood flow with (99m)Tc-hexamethylpropyleneamine oxime single-photon emission computed tomography and 1-point venous blood sampling.
abstract: OBJECTIVE
  The arterial and venous blood concentration of technetium 99m-labeled hexamethylpropyleneamine oxime ((99m)Tc-HMPAO) reaches an equilibration more rapidly than other CBF tracers. We hypothesized that (99m)Tc radioactivity of a venous sample at equilibrium, which is similar to that of an arterial sample, would allow estimation of the integrated input function for the clinical measurement of CBF by use of single-photon emission CT.
  
  
  METHODS
  In 53 patients with stable cerebrovascular disease, the radioactivity of a venous sample 5 minutes after injection of (99m)Tc-HMPAO was correlated with 5-minute arterial blood radioactivity and the first 5 minutes of the integrated arterial curves of the lipophilic tracer. The measured CBF values were compared with those of xenon 133.
  
  
  RESULTS
  The radioactivity of 5-minute venous blood was almost equivalent to that of 5-minute arterial blood (r(2) = 0.987; y = 0.993x + 1.63; P : <0.0001). The correlation between the venous blood radioactivity and the integrated arterial lipophilic fraction was excellent (r(2) = 0.935, P : <0.0001). A strong correlation was obtained between (99m)Tc-HMPAO and (133)Xe CBF values (r(2) = 0.825, P : <0.0001). CBF values were reproducible (coefficient of variation, 8.6%).
  
  
  CONCLUSIONS
  This approach is fast, simple, and an alternative to continuous blood sampling in clinical quantitative (99m)Tc-HMPAO CBF studies.
authors.affiliation: Department of Internal Medicine, Osaka National Hospital, Osaka, Japan. yoshisk@onh.go.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Isaka
authors.forename: S
authors.initials: S
authors.lastname: Furukawa
authors.forename: H
authors.initials: H
authors.lastname: Etani
authors.forename: E
authors.initials: E
authors.lastname: Nakanishi
authors.forename: Y
authors.initials: Y
authors.lastname: Ooe
authors.forename: M
authors.initials: M
authors.lastname: Imaizumi
mesh_terms: D001158:Arteries; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow; D019690:Technetium Tc 99m Exametazime / Q000097:blood; D013997:Time Factors; D014055:Tomography, Emission-Computed; D014680:Veins; D014980:Xenon Radioisotopes
chemical_list: D019275:Radiopharmaceuticals; D014980:Xenon Radioisotopes; D019690:Technetium Tc 99m Exametazime