Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis.
Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericin B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.
Kirkpatrick
W R
WR
Departments of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. KIRKPATRICK@UTHSCSA.EDU
McAtee
R K
RK
Fothergill
A W
AW
Rinaldi
M G
MG
Patterson
T F
TF
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000187:drug effects; D005446:Fluocinolone Acetonide / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D006168:Guinea Pigs; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D009924:Organ Culture Techniques; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D011743:Pyrimidines; D014230:Triazoles; D005446:Fluocinolone Acetonide; D000666:Amphotericin B; D065819:Voriconazole