Modifier genes of hereditary hearing loss.
Phenotypic variation between individuals with the same disease alleles may be attributable to the genotype at another locus, which is referred to as a modifier gene. Recent functional studies of modifier genes of hearing-loss loci have begun to refine our understanding of hearing processes and will guide the rational design of medical therapies for hearing loss.
Friedman
T
T
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA. friedman@nihcd.nih.gov
Battey
J
J
Kachar
B
B
Riazuddin
S
S
Noben-Trauth
K
K
Griffith
A
A
Wilcox
E
E
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003638:Deafness / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D005838:Genotype; D006198:Hair Cells, Auditory / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D009154:Mutation / Q000235:genetics*; D010641:Phenotype