title: Clinical application of GnRH-antagonists.
abstract: Due to the different pharmacological mode of action, GnRH-antagonists seem to open up new avenues to hormonal treatment in several indications. Although it may be still too early to speculate about the possible end of the era of GnRH-agonists, from what is known today, the advantages of GnRH-antagonists are most evident in our opinion. When the development of sustained delivery systems may continue and be completed, the antagonists will have a major potential within benign gynecological conditions and also in the treatment of malignancies such as prostatic, mammary, endometrial or ovarian cancer. Suitable sustained delivery systems and the development of GnRH-antagonists with sufficient oral bioavailability, represent the present and future challenge for these efforts.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. rfelberbau@aol.com
authors.forename: R E
authors.initials: RE
authors.lastname: Felberbaum
authors.forename: M
authors.initials: M
authors.lastname: Ludwig
authors.forename: K
authors.initials: K
authors.lastname: Diedrich
mesh_terms: D017326:Clinical Trials, Phase III as Topic; D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy; D008297:Male; D008596:Menotropins / Q000008:administration & dosage; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D010062:Ovulation Induction / Q000379:methods; D010902:Pituitary Gland / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy
chemical_list: D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins; D005640:Follicle Stimulating Hormone