title: MER53, a non-autonomous DNA transposon associated with a variety of functionally related defense genes in the human genome.
abstract: We report a new medium reiteration frequency repeat MER53 present in human and mammalian genomes. A 189 bp MER53 consensus sequence has been reconstructed based on the computer analysis of GenBank sequences. TA target site duplication and terminal inverted repeats indicate that the MER53 repeat is a non-autonomous DNA transposon related to the mariner family. Two MER53 repeats were found integrated within different mobile elements. We have found that most of the genes harboring the MER53 repeat are involved in the host defense system. The reasons for this non-random distribution of the repeat are discussed.
authors.affiliation: Genetic Information Research Institute, Palo Alto, CA 94306, USA.
authors.forename: V V
authors.initials: VV
authors.lastname: Kapitonov
authors.forename: J
authors.initials: J
authors.lastname: Jurka
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics; D053818:Chymases; D037222:Collectins; D004251:DNA Transposable Elements; D005340:Fibrinogen / Q000235:genetics; D015894:Genome, Human; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007066:Iduronate Sulfatase / Q000235:genetics; D039661:Integrin beta3; D016209:Interleukin-8 / Q000235:genetics; D007527:Isoenzymes / Q000235:genetics; D019272:Leukocyte Elastase / Q000235:genetics; D058965:MART-1 Antigen; D008432:Mathematical Computing; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D018991:Myelin Proteolipid Protein / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics; D010980:Platelet Membrane Glycoproteins / Q000235:genetics; D011493:Protein Kinase C / Q000235:genetics; D064546:Protein Kinase C beta; D011971:Receptors, Immunologic / Q000235:genetics; D012262:Ribonucleoside Diphosphate Reductase / Q000235:genetics; D012697:Serine Endopeptidases / Q000235:genetics; D000509:alpha-Fetoproteins / Q000235:genetics
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D002352:Carrier Proteins; D037222:Collectins; D004251:DNA Transposable Elements; C075005:GNLY protein, human; D039661:Integrin beta3; D016209:Interleukin-8; D007527:Isoenzymes; D058965:MART-1 Antigen; C548667:MLANA protein, human; D008565:Membrane Proteins; D018991:Myelin Proteolipid Protein; D009363:Neoplasm Proteins; D010980:Platelet Membrane Glycoproteins; D011971:Receptors, Immunologic; D000509:alpha-Fetoproteins; C080086:phosphatidylinositol glycan-class A protein; D005340:Fibrinogen; C093713:ribonucleotide reductase M2; D012262:Ribonucleoside Diphosphate Reductase; D005982:Glutathione Transferase; C119995:glutathione S-transferase alpha; D011493:Protein Kinase C; D064546:Protein Kinase C beta; D007066:Iduronate Sulfatase; D012697:Serine Endopeptidases; D019272:Leukocyte Elastase; D053818:Chymases