Synthesis and antimicrobial activity of some new 2-indolinone derived oximes and spiro-isoxazolines.
The synthesis and spectral analysis of some new 1,3-dihydro-3-hydroxy-3-[2-hydroxyimino-2-(substituted phenyl)ethyl]-2H-indol-2-ones (21-32) and spiro[3H-indol-3,5'-(4'H)-isoxazol]-2(1H)-ones (33-44) are described. Sixteen of the synthesized compounds were screened in vitro for their growth inhibitory activity against thirteen species of microorganisms, viz, S. aureus, S. epidermidis, S. faecalis, B. subtilis, B. cereus, E. aerogens, E. coli, P. aeruginosa, P. vulgaris, A. baumonia, A. faecalis, C. albicans and S. cervicae. Most of the compounds exhibited significant antimicrobial activity especially the oximes 28 and 29.
El-Gendy
A A
AA
Department of Organic Chemistry and Microbiology, Faculty of Pharmacy, Cairo University, Egypt. elgendy1@Yahoo.com
Ahmedy
A M
AM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology; D000078183:Oxindoles; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007211:Indoles; D007555:Isoxazoles; D010091:Oximes; D000078183:Oxindoles; C022960:2-oxindole