Association of a functional polymorphism of the monoamine oxidase A gene promoter with personality and psychiatric symptoms.
A functional polymorphism in the promoter of the monoamine oxidase gene has recently been described by Sabol et al. This polymorphism is a strong candidate for associations with personality traits and psychiatric symptoms. We report relevant data from a general population sample of 850 Caucasian Australians. We found no associations with anxiety and depression symptoms, with personality traits that predispose to anxiety (neuroticism, behavioral inhibition, negative affect) or to a personality trait related to antisocial behavior (psychoticism).
Jorm
A F
AF
Centre for Mental Health Research, The Australian National University, Canberra. anthony.jorm@anu.edu.au
Henderson
A S
AS
Jacomb
P A
PA
Christensen
H
H
Korten
A E
AE
Rodgers
B
B
Tan
X
X
Easteal
S
S
D000328:Adult; D001008:Anxiety Disorders / Q000235:genetics; D001315:Australia; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D001523:Mental Disorders / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics*; D010554:Personality Disorders / Q000201:enzymology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D011618:Psychotic Disorders / Q000201:enzymology / Q000235:genetics*; D044465:White People / Q000235:genetics*
D007527:Isoenzymes; D008995:Monoamine Oxidase