1,4-Hydrogen radical transfer as a new and versatile tool for the synthesis of enantiomerically pure 1,2,3-triols
[reaction: see text]1,4-Hydrogen radical transfers can now be reliably envisaged in radical synthetic chemistry as demonstrated by the formation of the cyano derivative II from I. Due to related sequences involving this new translocation process, followed by a highly diastereoselective trapping of the resulting anomeric radical, access to intriguing enantiopure 1,2,3-triols such as III is available.
Gulea
M
Universite Pierre et Marie Curie, Laboratoire de Chimie Organique de Synthese, associe au CNRS, Paris, France.
Lopez-Romero
JM
Fensterbank
L
Malacria
M