title: [Analysis of HLA class I and II antigens composition in high-risk pregnancy].
abstract: METHODS
  We have analyzed the frequency of HLA class I and II antigens in high-risk pregnancy.
  
  
  METHODS
  Altogether, 22 gravida hospitalized at the Department of Pathology of Pregnancy and Labour, Pomeranian Medical University in Szczecin formed group I (PE) with 12 cases of preeclampsia and group II with 10 cases of the antiphospholipid syndrome (APS). The control group included 40 multigravida. Typing of HLA class I and II antigens was done using the two-stage microcytotoxic test (NIH) of Mittal.
  
  
  RESULTS
  Antigen B35 was found more frequent in preeclampsia and antiphospholipid syndrome groups than in multigravida. Furthermore, a statistically significant difference in the frequency of homozygotes for the HLA-DR locus was noted between groups PE and APS on one hand, and controls on the other.
  
  
  CONCLUSIONS
  Identical HLA-DR3, DR4 and DR5 antigens were found more frequently in preeclampsia, while identical DR4 and DR6 in the antiphospholipid syndrome.
authors.affiliation: Katedry i Zakładu Mikrobiologii i Immunologii PAM w Szczecinie.
authors.forename: A
authors.initials: A
authors.lastname: Mikłaszewicz
authors.forename: O
authors.initials: O
authors.lastname: Szmigiel-Sipak
authors.forename: E
authors.initials: E
authors.lastname: Ronin-Walknowska
authors.forename: J
authors.initials: J
authors.lastname: Hałasa
authors.forename: S
authors.initials: S
authors.lastname: Giedrys-Kalemba
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D005260:Female; D006684:HLA-DR Antigens / Q000276:immunology*; D006801:Humans; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D018566:Pregnancy, High-Risk / Q000276:immunology*
chemical_list: D006684:HLA-DR Antigens