Facile and efficient one-pot synthesis of 4beta-arylaminopodophyllotoxins: synthesis of DNA topoisomerase II inhibitors (NPF and W-68).
A series of 4beta-arylamino-4'-O-demethylepipodophyllotoxins and 4beta-arylaminoepipodophyllotoxins have been synthesized with significant stereoselectivity and improved yields by employing the methanesulphonic acid/sodium iodide reagent system. Compounds NPF. W-68 and other DNA topoisomerase II inhibitors are prepared in good to excellent yields by this method and these are active or more active than etoposide in their inhibition of the human DNA topoisomerase II.
Kamal
A
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad. ahmedkamal@iict.ap.nic.in
Laxman
N
N
Ramesh
G
G
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000191:economics; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000191:economics; D011034:Podophyllotoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000191:economics; D059005:Topoisomerase II Inhibitors
D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors; D011034:Podophyllotoxin