title: Effects of normothermic cardiopulmonary bypass on bispectral index.
abstract: This study investigated the changes in the hypnotic component of anaesthesia, estimated by the bispectral index of the electroencephalogram, during normothermic cardiopulmonary bypass. Twenty-six patients (20 men, 6 women), aged 61 +/- 11 years (Mean +/- SD) scheduled for cardiac surgery were premedicated with hydroxyzine and meperidine. Anaesthesia was induced and maintained with a computer-controlled continuous infusion (not adjusted for haemodilution) of sufentanil (effect site concentration 0.4-0.6 ng mL-1) and a manually adjusted continuous infusion of propofol (4.4 +/- 1.8 mg kg-1 h-1). Cardiopulmonary bypass was normothermic with moderate haemodilution. Bispectral index was measured with a referential montage before, 30 s, 1, and 3 min after cardiopulmonary bypass onset, before and after aortic cross-clamping, 30 min after cardiopulmonary bypass onset, before and after aorta cross-clamp release and before and after weaning from cardiopulmonary bypass. Bispectral index values were 48 +/- 8 before cardiopulmonary bypass onset, 50 +/- 10 before, and 48 +/- 8 after end of cardiopulmonary bypass (P = NS). No patient had increases in bispectral index values during cardiopulmonary bypass consistent with awakening. We conclude that with the anaesthetic regimen presented in this study bispectral index values do not change during normothermic cardiopulmonary bypass.
authors.affiliation: Department of Anaesthesia and Intensive Care, Centre Hospitalier Universitaire de Nancy, Hôpital Brabois, 54500 Vandoeuvre-les-Nancy, France.
authors.forename: M
authors.initials: M
authors.lastname: Hirschi
authors.forename: C
authors.initials: C
authors.lastname: Meistelman
authors.forename: D
authors.initials: D
authors.lastname: Longrois
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage / Q000627:therapeutic use; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D001011:Aorta / Q000601:surgery; D001364:Awareness / Q000187:drug effects; D001831:Body Temperature; D002315:Cardiopulmonary Bypass; D003250:Constriction; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006438:Hemodilution; D006801:Humans; D006919:Hydroxyzine / Q000627:therapeutic use; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use*; D007260:Infusion Pumps; D008297:Male; D011939:Mental Recall / Q000187:drug effects; D008614:Meperidine / Q000627:therapeutic use; D008875:Middle Aged; D011229:Preanesthetic Medication; D015742:Propofol / Q000008:administration & dosage; D012815:Signal Processing, Computer-Assisted; D017409:Sufentanil / Q000008:administration & dosage
chemical_list: D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D006919:Hydroxyzine; D008614:Meperidine; D017409:Sufentanil; D015742:Propofol