title: The binding of cocaine to cyclodextrins.
abstract: Cocaine binds into beta-cyclodextrin, but not detectably into alpha- or gamma-cyclodextrin, in water solution. NMR studies indicate the geometry of the complex, which is confirmed by molecular mechanics calculations and binding studies on cocaine analogues and cyclodextrin dimers.
authors.affiliation: Department of Chemistry, Columbia University, New York, NY 10027, USA.
authors.forename: N
authors.initials: N
authors.lastname: Nesna
authors.forename: J
authors.initials: J
authors.lastname: Lou
authors.forename: R
authors.initials: R
authors.lastname: Breslow
mesh_terms: D003042:Cocaine / Q000737:chemistry / Q000378:metabolism*; D003505:Cyclodextrins / Q000737:chemistry / Q000378:metabolism*; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy
chemical_list: D003505:Cyclodextrins; D003042:Cocaine