[The erythron system in body exposure to nitrogen oxides].
OBJECTIVE
Assessment of erythron parameters in subjects exposed occupationally to nitrogen oxides polluted air versus those who work in healthy environment.


METHODS
Levels of red cells, reticulocytes, packed cell volume, resistance of red cell membranes to acid buffer were measured in 95 subjects working in polluted environment and 89 healthy controls.


RESULTS
Long-term (10 years and longer) contact with nitrogases entails a tendency to lowering of red cell number in the exposed subjects, significant rise of packed cell volume, increased mean cell volume of red cells, anisocytosis and reticulocytosis, high acid resistance of red cells and their membrane permeability. The causes of these changes are discussed in terms of "uneffective erythropoiesis" conception.


CONCLUSIONS
Thus, erythron parameters can serve for indication of toxic effects of some chemicals on human body.
Shmarov
D A
DA
Vorob'eva
T I
TI
Lapotnikov
I A
IA
Kozinets
G I
GI
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D002908:Chronic Disease; D004906:Erythrocyte Count / Q000706:statistics & numerical data; D004909:Erythrocyte Indices / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009589:Nitrogen Oxides / Q000009:adverse effects*; D009784:Occupational Diseases / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D011041:Poisoning / Q000097:blood / Q000175:diagnosis / Q000209:etiology
D000395:Air Pollutants, Occupational; D009589:Nitrogen Oxides