Dimerization of human growth hormone in the presence of metal ions.
Zn(2+) and Co(2+) ions are known to promote human growth hormone reversible dimerization. In these studies, dimerization was also shown to be initiated by nine other metal ions: Cd(2+), Hg(2+), Cu(2+), Ag+, Au(3+), Au+, Pd(2+), Ni(2+), and Pt(4+). In some cases (Hg(2+), Ag(+), Au(3+), and Ni(2+)) formation of higher oligomers also took place. In addition further detailed investigation of dimerization in the presence of Zn(2+) ions was carried out.
Dienys
G
G
Faculty of Chemistry, Vilnius University, Lithuania, and Institute of Biotechnology, Graiciūno 8, Vilnius 2028, Lithuania.
Sereikaite
J
J
Luksa
V
V
Jarutiene
O
O
Mistiniene
E
E
Bumelis
V A
VA
D000595:Amino Acid Sequence; D002412:Cations; D003432:Cross-Linking Reagents; D019281:Dimerization; D019382:Human Growth Hormone / Q000737:chemistry* / Q000187:drug effects; D006801:Humans; D019216:Metals, Heavy / Q000494:pharmacology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry; D014227:Triazines / Q000494:pharmacology; D014357:Trypsin
D002412:Cations; D003432:Cross-Linking Reagents; D019216:Metals, Heavy; D010446:Peptide Fragments; D014227:Triazines; D019382:Human Growth Hormone; D014357:Trypsin; C049485:1,3,5-triacryloylhexahydrotriazine