title: Microecologic approaches for traveler's diarrhea, antibiotic-associated diarrhea, and acute pediatric diarrhea.
abstract: Bacterial and viral diarrhea remain important causes of morbidity and mortality throughout the world. Current concerns with medical costs, increasing frequency of antibiotic resistance, and overuse of antibiotics in general have redirected therapeutic approaches for diarrhea from traditional drugs to the use of living therapeutic organisms. Awareness of the important role of normal flora in the microecology of the intestines in fighting infection, along with the recent availability of well-controlled clinical trials for these agents, has brought microecologic therapies to the forefront of clinical practice.
authors.affiliation: Department of Medicinal Chemistry, University of Washington. Correspondence to author at Biocodex, Inc., 1910 Fairview Avenue East, #208, Seattle, WA 98102, USA.
authors.forename: L V
authors.initials: LV
authors.lastname: McFarland
mesh_terms: D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D018849:Controlled Clinical Trials as Topic; D003967:Diarrhea / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology*; D004463:Ecology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D014195:Travel; D014481:United States / Q000453:epidemiology; D014944:World Health Organization
chemical_list: D000900:Anti-Bacterial Agents