Quantitative structure-intestinal permeability relationship of benzamidine analogue thrombin inhibitor.
The intestinal permeability of benzamidine analogue thrombin inhibitor is correlated with molecular volume, lipophilicity (calculated log P and IAM column capacity factor), hydrogen bond acidity/basicity and dipolarity.
Sugano
K
K
Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd, Shizuoka, Japan. suganokyh@chugai-pharm.co.jp
Yoshida
S
S
Takaku
M
M
Haramura
M
M
Saitoh
R
R
Nabuchi
Y
Y
Ushio
H
H
D001550:Benzamidines / Q000493:pharmacokinetics*; D007413:Intestinal Mucosa / Q000378:metabolism*; D010539:Permeability; D021281:Quantitative Structure-Activity Relationship; D012995:Solubility; D013917:Thrombin / Q000037:antagonists & inhibitors*
D001550:Benzamidines; D013917:Thrombin