title: Synthesis and immunomodulating activity of 5H-thiazolo[2,3-b]quinazolin-3(2H)-one.
abstract: The synthesis and immunomodulating activity of 5H-thiazolo[2,3-b]quinazoline-3(2H)-one (7) are described. When tested in the Kennedy plaque assay, 7 exerted immunosuppressive activity on IgM production in female C3H mice sensitized with sheep erythrocytes.
authors.affiliation: Department of Organic Chemistry, Pennwalt Corporation, Rochester, NY 14623, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Bennett
authors.forename: L A
authors.initials: LA
authors.lastname: Radov
authors.forename: L A
authors.initials: LA
authors.lastname: Trusso
authors.forename: V S
authors.initials: VS
authors.lastname: Georgiev
mesh_terms: D000818:Animals; D005260:Female; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C414045:5H-thiazolo(2,3-b)quinazolin-3(2H)-one; D007166:Immunosuppressive Agents; D011799:Quinazolines; D013844:Thiazoles