Protein folding: pulling back the frontiers.
In the past few years, it has become possible to measure the forces required to mechanically unfold single protein molecules. Recently, the mechanical properties of heteropolyproteins have been studied, shedding new light on the mechanical design of modular proteins such as titin.
Smith
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Department of Physics and Astronomy, Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK.
Radford
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D064211:Connectin; D004548:Elasticity; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D018625:Microscopy, Atomic Force; D009124:Muscle Proteins / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D013314:Stress, Mechanical
D064211:Connectin; D008565:Membrane Proteins; D009124:Muscle Proteins; D011494:Protein Kinases