title: A case of minute intraductal papillary mucinous tumor of the pancreas presenting with recurrent acute pancreatitis.
abstract: Intraductal papillary mucinous tumor (IPMT) of the pancreas, a lesion consisting of mucin-producing cells with neoplastic potential, is characterized by duct ectasia, mucin hypersecretion, often extensive papillary intraductal growth, varying degrees of cytologic atypia, and relatively indolent growth. The clinical presentation of IPMT of the pancreas is characterized by chronic or recurrent attacks of abdominal discomfort often in association with low level pancreatic enzyme elevations. Less commonly these lesions may be detected as asymptomatic radiographic abnormalities. Interestingly, a case of a minute IPMT (2 mm in height and 7 mm in length, adenoma) in the main pancreatic duct presenting with acute pancreatitis in a 55 year-old man has been reported in the Japanese literature. Recently, we also experienced a case of a minute IPMT in a branch pancreatic duct causing repeated bouts of acute pancreatitis in a 75 year-old man. A filling defect at the neck of the main pancreatic duct seen on an endoscopic retrograde pancreatogram performed after recovery of the second attack of acute pancreatitis led the patient to undergo an exploratory laparotomy. After a near-total pancreatectomy was carried out, a minute (3 x 7 mm) IPMT of borderline malignancy was discovered in a branch duct at the head portion near the pancreatic neck without any lesions in the main pancreatic duct. Surprisingly, despite the resective surgery the patient died of carcinomatosis 8.5 months after the operation. We herein report a case of a minute but aggressive IPMT of the pancreas with a review of the literature.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. chungjp@yumc.yonsei.ac.kr
authors.forename: J P
authors.initials: JP
authors.lastname: Chung
authors.forename: S W
authors.initials: SW
authors.lastname: Chi
authors.forename: Y N
authors.initials: YN
authors.lastname: Park
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: S Y
authors.initials: SY
authors.lastname: Song
authors.forename: K S
authors.initials: KS
authors.lastname: Lee
authors.forename: J B
authors.initials: JB
authors.lastname: Chung
authors.forename: S I
authors.initials: SI
authors.lastname: Lee
authors.forename: J K
authors.initials: JK
authors.lastname: Kang
authors.forename: K W
authors.initials: KW
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Chi
mesh_terms: D000208:Acute Disease; D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde; D006801:Humans; D008297:Male; D009077:Mucins / Q000378:metabolism*; D010183:Pancreatic Ducts / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology*; D012008:Recurrence; D014057:Tomography, X-Ray Computed
chemical_list: D009077:Mucins