Lipid peroxide levels in chronic renal failure.
To determine presence of oxidant stress in chronic renal failure and to evaluate the efficacy of vitamin E in its amelioration, we studied 34 patients (Group I, age 32.4 +/- 11 years, M:F 3:1) and 10 healthy controls (Group II, age 27.4 +/- 5 years, M:F 4:1). The difference in baseline values of lipid peroxide (nmol/ml) was statistically significant (Group I 4.19 +/- 1.69, Group II 1.87 +/- 1.39, p = 0.004). Values of vitamin E (mg/l) were also significantly lower in Group I as compared to Group II (12.18 +/- 4.27 vs. 19.32 +/- 2.03, p = 0.003). Serum lipid peroxide values decreased significantly after supplementation with 400 mg/day of vitamin E for six weeks in Group I (4.19 +/- 1.69 to 3.21 +/- 1.13, p = 0.053) but not in Group II (1.87 +/- 1.39 to 1.03 +/- 0.87). Levels of vitamin E increased in both the groups (Group I: 12.18 +/- 4.27 to 16.01 +/- 5.13, Group II: 19.32 +/- 2.03 to 23.21 +/- 1.94, p < 0.005). No significant difference was observed in values of serum creatinine and urea before and after intervention.
Sharma
A K
AK
Dept. of Nephrology, Monilek Hospital and Research Centre, Jaipur.
Arora
M
M
Goyle
A
A
Jain
R
R
Gupta
H
H
Gupta
R
R
D000328:Adult; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000188:drug therapy*; D007677:Kidney Function Tests; D008054:Lipid Peroxides / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
D008054:Lipid Peroxides; D014810:Vitamin E