Cortical reorganization following multiple subpial transection in human brain - a study with positron emission tomography.
We investigated the cortical activation pattern in a 30-year-old woman 4 years after multiple subpial transection (MST) of the right fronto-parietal cortex and six healthy controls using positron emission tomography. Sequential finger-to-thumb opposition at the frequency of 1.5 Hertz contralateral to the operated hemisphere was used as the activation paradigm. We found preserved cortical activation in the transected fronto-parietal cortex and additional activation of the prefrontal cortex bilaterally and the inferior parietal cortex contralaterally when compared with the control group. This activation pattern indicates that MST induces a rather selective lesion leaving the cortical structures functionally intact. However, it necessitates the recruitment of additional motor areas.
Leonhardt
G
G
Department of Neurology, University of Essen, Hufelandstrasse 55, D-45122, Essen, Germany. georg.leonhardt@uni-essen.de
Spiekermann
G
G
Müller
S
S
Zentner
J
J
Hufnagel
A
A
D000328:Adult; D001783:Blood Flow Velocity; D004827:Epilepsy / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology / Q000601:surgery; D010841:Pia Mater / Q000601:surgery; D017397:Prefrontal Cortex / Q000503:physiopathology / Q000601:surgery; D013003:Somatosensory Cortex / Q000098:blood supply / Q000503:physiopathology* / Q000601:surgery*; D014055:Tomography, Emission-Computed