title: Age- and sex-related bone uptake of Tc-99m-HDP measured by whole-body bone scanning.
abstract: AIM of this study was to validate a recently introduced new and easy-to-perform method for quantifying bone uptake of Tc-99m-labelled diphosphonate in a routine clinical setting and to establish a normal data base for bone uptake depending on age and gender.
  
  
  METHODS
  In 49 women (14-79 years) and 47 men (6-89 years) with normal bone scans as well as in 49 women (33-81 years) and 37 men (27-88 years) with metastatic bone disease whole-body bone scans were acquired at 3 min and 3-4 hours p.i. to calculate bone uptake after correction for both urinary excretion and soft tissue retention.
  
  
  RESULTS
  Bone uptake values of various age-related subgroups showed no significant differences between men and women (p > 0.05). Furthermore, no differences could be proven between age-matched subgroups of normals and patients with less than 10 metastatic bone lesions, while patients with wide-spread bone metastases revealed significantly increased uptake values. In both men and women highest bone uptake was obtained (p < 0.05) in subjects younger than 20 years with active epiphyseal growth plates. In men, bone uptake slowly decreased with age up to 60 years and then showed a tendency towards increasing uptake values. In women, the mean uptake reached a minimum in the decade 20-29 years and then slowly increased with a positive linear correlation of age and uptake in subjects older than 55 years (r = 0.57).
  
  
  CONCLUSIONS
  Since the results proposed in this study are in good agreement with data from literature, the new method used for quantification could be validated in a large number of patients. Furthermore, age- and sex-related normal bone uptake values of Tc-99m-HDP covering a wide range of age could be presented for this method as a basis for further studies on bone uptake.
authors.affiliation: Klinik für Nuklearmedizin, Christian-Albrechts-Universität zu Kiel. wbrenner@nuc-med.uni-kiel.de
authors.forename: W
authors.initials: W
authors.lastname: Brenner
authors.forename: N
authors.initials: N
authors.lastname: Sieweke
authors.forename: K H
authors.initials: KH
authors.lastname: Bohuslavizki
authors.forename: W U
authors.initials: WU
authors.lastname: Kampen
authors.forename: M
authors.initials: M
authors.lastname: Zuhayra
authors.forename: M
authors.initials: M
authors.lastname: Clausen
authors.forename: E
authors.initials: E
authors.lastname: Henze
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D002648:Child; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012737:Sex Factors; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate