title: Comparative study designs and what they show.
abstract: Normally an increase in lung deposition leads to an improved clinical effect. An increase in clinical effect should be substantial (two-fold or greater) in order to be detected even in carefully conducted clinical trials. Further studies are needed in order to define the best clinical study designs with which to detect differences between different inhalers.
authors.affiliation: Department of Pediatrics, Kolding Sygehus, Denmark. spconsult@post1.tele.dk
authors.forename: S
authors.initials: S
authors.lastname: Pedersen
mesh_terms: D018927:Anti-Asthmatic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000493:pharmacokinetics / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D012107:Research Design; D013256:Steroids
chemical_list: D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D013256:Steroids