Antiradiation compounds: XXI. Metal ion complexation of bis(methylthio) and methylthio amino derivatives of 1-methylquinolinium-2-dithioacetic acids.
With the assumption that the radiation-protective ability (whole body protection of mice) of the bis(methylthio) and methylthio amino derivatives of the 1-methylquinolinium-2-dithioacetic acids may be due to complexation of copper or zinc ions in vivo, the ability of these compounds to form stable metal complexes has been observed. Metal ion stability constants have been determined for three of the compounds with Al(III), Cu(II), Fe(III), and Zn(II) ions, and stabilities somewhat larger than those for simple peptides were found. Structures of the Cu(II) and Fe(III) complexes are proposed, based on elemental analyses and infrared absorption. The Cu(II) complexes are 1:1 ligand:metal structures that precipitated as double salts with CuCl2, and the Fe(III) complexes are 2:1 structures in which the ligands incorporated an additional sulfur atom.
Foye
W O
WO
Samuel M. Best Research Laboratory, Massachusetts College of Pharmacy and Allied Health Sciences, Boston 02115, USA.
Patarapanich
S
S
D000535:Aluminum / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D004355:Drug Stability; D007501:Iron / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D011804:Quinolines / Q000737:chemistry*; D011837:Radiation-Protective Agents / Q000737:chemistry*; D015032:Zinc / Q000378:metabolism
C414046:1-methylquinolinium-2-dithioacetic acid; D008670:Metals; D011804:Quinolines; D011837:Radiation-Protective Agents; D003300:Copper; D000535:Aluminum; D007501:Iron; D015032:Zinc