title: Design and synthesis of triglyceride analogue biotinylated suicide inhibitors for directed molecular evolution of lipolytic enzymes.
abstract: The design, synthesis, and inhibition properties of two new triglyceride analogue biotinylated suicide inhibitors (2) and (3) for directed molecular evolution of lipolytic enzymes by phage-display is described.
authors.affiliation: Protein Discovery, Novo Nordisk A/S, Bagsvaerd, Denmark. hjdu@novo.dk
authors.forename: H J
authors.initials: HJ
authors.lastname: Deussen
authors.forename: S
authors.initials: S
authors.lastname: Danielsen
authors.forename: J
authors.initials: J
authors.lastname: Breinholt
authors.forename: T V
authors.initials: TV
authors.lastname: Borchert
mesh_terms: D000345:Affinity Labels; D019921:Biotinylation; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors*; D014280:Triglycerides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000345:Affinity Labels; D004791:Enzyme Inhibitors; D014280:Triglycerides; D008049:Lipase