Syntheses and antifungal activity of pseudomycin side-chain analogues. Part 1.
We have described herein the syntheses of three novel series of aromatic ring containing pseudomycin side-chain analogues. Preliminary biological evaluations of these analogues clearly indicate that it is possible to synthesize rigid pseudomycin side-chain analogues without compromising in vitro antifungal activity.
Jamison
J
J
Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
Levy
S
S
Sun
X
X
Zeckner
D
D
Current
W
W
Zweifel
M
M
Rodriguez
M
M
Turner
W
W
Chen
S H
SH
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011549:Pseudomonas / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D010456:Peptides, Cyclic; C107665:pseudomycin A