A comparison of inverse-detected heteronuclear NMR performance: conventional vs cryogenic microprobe performance.
We report a comparison of the results obtained at 500 MHz for heteronuclear shift correlation (HSQC) experiments with very small natural product samples using conventional and cryogenically cooled 3 mm NMR probes. The cryo probe affords a 12- to 16-fold reduction in data acquisition time for a comparable signal-to-noise ratio.
Russell
D J
DJ
Rapid Structure Characterization Group, Pharmaceutical Development, Pharmacia Corporation, Kalamazoo, Michigan 49001-0199, USA.
Hadden
C E
CE
Martin
G E
GE
Gibson
A A
AA
Zens
A P
AP
Carolan
J L
JL
D003080:Cold Temperature; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D011042:Poisons / Q000737:chemistry*; D013331:Strychnine / Q000737:chemistry*
D011042:Poisons; D013331:Strychnine