title: Effects of 17 beta-estradiol and its isomer 17 alpha-estradiol on learning in rats with chronic cholinergic deficiency in the brain.
abstract: It was shown for the first time that estrogens 17 beta- and 17 alpha-estradiols compensate impaired cognitive functions in rats with partial chronic deprivation of cholinergic functions in the central nervous system induced by intracerebral administration of selective cholinergic neurotoxin AF64A. 17 beta-Estradiol produced strong dose-dependent changes in the weights of hormone-sensitive endocrine glands, while 17 alpha-estradiol did not affect the weight of the gonads and slightly influenced (in high concentration) the weights of the adrenal glands and thymus. The positive effects of exogenous 17 beta- and 17 alpha-estradiols on cognitive functions are due to their antioxidant properties, rather than due to specific action on hormone-sensitive endocrine glands.
authors.affiliation: Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow region.
authors.forename: N N
authors.initials: NN
authors.lastname: Lermontova
authors.forename: V K
authors.initials: VK
authors.lastname: P'chev
authors.forename: B K
authors.initials: BK
authors.lastname: Beznosko
authors.forename: G I
authors.initials: GI
authors.lastname: Van'kin
authors.forename: T A
authors.initials: TA
authors.lastname: Ivanova
authors.forename: I V
authors.initials: IV
authors.lastname: Koroleva
authors.forename: E A
authors.initials: EA
authors.lastname: Lukoyanova
authors.forename: T V
authors.initials: TV
authors.lastname: Mukhina
authors.forename: T P
authors.initials: TP
authors.lastname: Serkova
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D004958:Estradiol / Q000494:pharmacology* / Q000502:physiology; D007858:Learning; D020033:Protein Isoforms / Q000494:pharmacology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011950:Receptors, Cholinergic / Q000502:physiology*
chemical_list: D020033:Protein Isoforms; D011950:Receptors, Cholinergic; D004958:Estradiol