title: Parvovirus B19 infection reminiscent of myelodysplastic syndrome in three children with chronic hemolytic anemia.
abstract: The authors have seen transient pancytopenia with erythroid hypoplasia and striking trilineage myelodysplasia reminiscent of true myelodysplastic syndrome (MDS) in 3 children, 1 with thalassemia intermedia and the other 2 with previously undiagnosed hereditary spherocytosis. In these 3 children transient pancytopenia and myelodysplasia coincided with serological evidence of acute parvovirus-B19 (PV-B19) infection, strongly suggesting their relevance. It is of interest that these 3 cases were encountered within a period of 6 months. This might be an incidental event, but it might also be concluded that acute PV-B19 infection associated transient pancytopenia with morphological appearance of MDS may occur more frequently than reported in the literature. So, PV-B19-associated nonclonal MDS should be considered in the differential diagnosis of true clonal MDS.
authors.affiliation: Department or Pediatric Hematology, Dr. Sami Ulus Children's Disease Centre, Ankara, Turkey. yarali@ada.net.tr
authors.forename: N
authors.initials: N
authors.lastname: Yarali
authors.forename: F
authors.initials: F
authors.lastname: Duru
authors.forename: T
authors.initials: T
authors.lastname: Sipahi
authors.forename: A
authors.initials: A
authors.lastname: Kara
authors.forename: T
authors.initials: T
authors.lastname: Teziç
mesh_terms: D002648:Child; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000821:virology*; D010322:Parvoviridae Infections / Q000150:complications*; D017992:Parvovirus / Q000302:isolation & purification*; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000821:virology*; D013789:Thalassemia / Q000150:complications* / Q000821:virology*