title: Polymer-supported reagents for multi-step organic synthesis: application to the synthesis of sildenafil.
abstract: Sildenafil 1 (Viagra), a well known and commercially important pharmaceutical drug, has been prepared using polymer-supported reagents in a multi-step, convergent process resulting in a clean and efficient preparation without the need for conventional purification methods.
authors.affiliation: Department of Chemistry, University of Cambridge, UK.
authors.forename: I R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: S V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis*; D010879:Piperazines / Q000138:chemical synthesis*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones
chemical_list: D007202:Indicators and Reagents; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate