[Possibilities for genetic counseling in Alzheimer's disease].
A ventilator function of the lungs and indices of biomechanics of respiration were analyzed in 70 patients with progressive muscular dystrophy: 48 individuals with Erb-Roth's form (the 1-st group), 8 patients with Landouzy-Dejerine form (the 2-nd group) and 14 cases with Charcot-Marie's form (the 3-d group). Any clinical-roentgenologic signs of the pathology of bronchopulmonary system were absent in the patients. A control group consisted of 65 healthy individuals. All the patients were characterized by a moderate decrease of both maximal pulmonary ventilation and a volume of the forced expiration during the 1-st second, while the indices of the loop flow-volume were normal. Total work of breathing was normal too. Elastic fraction was increased significantly as compared with total work of respiration. Aerodynamic resistance was equal to normal values. Increase of total non-elastic resistance of lungs was conditioned by the elevation of the tissue resistance. Statistic stretching of the lungs was decreased in all the groups, while elastic tension of lungs--in the patients of the 1-st and 3-d groups. Obstructive type of the alteration of the ventilator function of the lungs was conditioned by non-pulmonary reasons. Alterations of the biomechanics of the respiration were considered as the functional ones.
Sadovnik
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AD
D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D006801:Humans