A new route to spirooxindoles.
[reaction: see text]Reaction of indole amides 5 with tributylstannane gave spiroindolenines 9 which are readily converted into spiropyrrolidinyloxindoles. This tricyclic system is found in a number of interesting natural products.
Hilton
S T
ST
School of Chemical and Pharmaceutical Sciences, Kingston University, Kingston-upon-Thames, Surrey, UK.
Ho
T C
TC
Pljevaljcic
G
G
Jones
K
K
D003500:Cyclization; D007202:Indicators and Reagents; D007211:Indoles / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates; D013141:Spiro Compounds / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D007211:Indoles; D008689:Methacrylates; D013141:Spiro Compounds; C036144:tri-n-butylstannylmethacrylate