Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists.
In acute experiments on Nembutal-anesthetized cats, the effect of opiate receptor agonists DAGO, DSLET, and dinorphin A(1-13) on the incidence of idioventricular rhythm disturbances, including ventricular tachycardia and fibrillation, was studied under conditions of occlusion of circumflex branch of the left coronary artery and stimulation of the sensorimotor cortex. The most pronounced effects were observed with DSLET and dinorphin A(1-13). These preparations completely prevented ventricular fibrillation. DAGO produced a less pronounced protective effect probably because of parallel increase in plasma catecholamine concentration.
Mikhailova
S D
SD
Russian State Medical University, Moscow.
Glushchenko
N V
NV
Semushkina
T M
TM
Storozhakov
G I
GI
D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000503:physiopathology*; D002415:Cats; D004399:Dynorphins / Q000494:pharmacology / Q000627:therapeutic use; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology / Q000627:therapeutic use; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D009044:Motor Cortex / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use; D011957:Receptors, Opioid / Q000819:agonists / Q000502:physiology*
D000701:Analgesics, Opioid; D000889:Anti-Arrhythmia Agents; D010446:Peptide Fragments; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004743:Enkephalin, Leucine; C026843:dynorphin (1-13); D004399:Dynorphins; C034318:enkephalin, Ser(2), Leu(5), Thr(6)-