Circulating levels of soluble E-selectin, P-selectin and intercellular adhesion molecule-1 in patients with juvenile idiopathic arthritis.
OBJECTIVE
To measure circulating levels of soluble E-selectin (sE-selectin), sP-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1) in patients with active juvenile idiopathic arthritides (JIA), and to evaluate their correlation with disease activity variables and cytokine levels.


METHODS
Serum levels of sE-selectin, sP-selectin, and sICAM-1 were measured by ELISA in 42 patients with JIA and in 15 healthy controls.


RESULTS
Circulating levels of sE-selectin and sICAM-1, but not sP-selectin, were significantly elevated in patients with active systemic JIA. In patients with active polyarticular or pauciarticular JIA serum levels of sE-selectin. sP-selectin, and sICAM-1 were comparable to those of controls. In patients with systemic JIA, levels of sE-selectin and sICAM-1 were significantly correlated with levels of soluble tumor necrosis factor receptor 2 (sTNFR2), but not with those of interleukin 6 (IL-6) or IL-1beta.


CONCLUSIONS
Patients with active systemic JIA have elevated circulating levels of sE-selectin and sICAM-1. The correlation with sTNFR2, together with previous data on the TNF system in systemic JIA. suggests that TNF activated endothelial cells are the source of sE-selectin and sICAM-1 in this disease.
De Benedetti
F
F
Clinica Pediatrica dell'Universita', Servizio di Epidemiologia Clinica e Biometria S Direzione Scientifica, IRCCS Policlinico S. Matteo, Pavia, Italy.
Vivarelli
M
M
Pignatti
P
P
Oliveri
M
M
Massa
M
M
Pistorio
A
A
Martini
A
A
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D019040:E-Selectin / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D019007:P-Selectin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D019040:E-Selectin; D007375:Interleukin-1; D015850:Interleukin-6; D019007:P-Selectin; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1