The influence of HLA genotyping compatibility on clinical outcome after cord blood transplantation from unrelated donors.
We performed retrospective DNA typing of class I (A, B, Cw) and class II (DRB1, DQB1, DPB1) HLA alleles in 27 unrelated cord blood transplantation (CBT) cases donated from a single cord blood bank (Kanagawa Cord Blood Bank). The influence of HLA genotype matching on clinical outcome was evaluated. From Cox's model, we found that incompatibility of two or more HLA alleles between the donor and recipient of an unrelated CBT was suggested to be a risk factor for a worse event-free survival (EFS) (p = 0.04; RR, 4.06; 95% CI, 1.06-15.61). Furthermore, mismatches including HLA-DRB1 alleles had an adverse effect on EFS (p = 0.04; RR, 4.91; 95% CI, 1.01-24.02). For definite conclusions on the role of HLA allele typing in unrelated CBT, more accumulation of data and analysis will be required.
Ohnuma
K
K
Department of Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
Isoyama
K
K
Ikuta
K
K
Toyoda
Y
Y
Nakamura
J
J
Nakajima
F
F
Nishihira
H
H
D000206:Actuarial Analysis; D000293:Adolescent; D000483:Alleles; D001787:Blood Group Incompatibility; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D005805:Genes, MHC Class I / Q000235:genetics; D005802:Genes, MHC Class II / Q000235:genetics; D005838:Genotype; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology; D006648:Histocompatibility / Q000235:genetics; D006650:Histocompatibility Testing / Q000379:methods* / Q000592:standards; D006801:Humans; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014019:Tissue Donors; D016378:Tissue Transplantation / Q000009:adverse effects* / Q000379:methods / Q000592:standards; D014181:Transplantation Immunology / Q000235:genetics; D016896:Treatment Outcome