title: Hormone replacement therapy in a postmenopausal woman with epilepsy.
abstract: OBJECTIVE
  To prospectively evaluate the effects of hormone replacement therapy (HRT) on seizure activity in a postmenopausal woman with epilepsy.
  
  
  BACKGROUND
  Postmenopausal women are at an increased risk for cardiovascular disease and osteoporosis secondary to a lack of estrogen's protective effects. As a result, women without known contraindications often take HRT to counteract this risk. Postmenopausal women with epilepsy are at a greater risk for osteoporosis because of the negative effects that certain antiepileptic drugs have on bone density. Clinical studies and experience have shown that hormonal variances across a woman's lifetime play a significant role in seizure activity, but the effects of HRT in postmenopausal women with epilepsy are unknown.
  
  
  METHODS
  We report the case of a 51-year-old postmenopausal white woman with epilepsy who presented with frequent vasomotor flushing. To determine individual effects of HRT on seizure activity, therapy was initiated in two three-month phases, with monthly evaluation. A weekly transdermal patch of estradiol 0.1 mg/d was initiated for the first three months. During the second three months, the regimen was expanded to include oral medroxyprogesterone acetate 2.5 mg once daily. Antiepileptic medications and their dosages remained constant. HRT was associated with a decreased incidence of seizures, cessation of vasomotor flushing, improved sleep, and a positive impact on the lipid profile.
  
  
  CONCLUSIONS
  This case report describing the prospective addition of HRT in a postmenopausal woman with epilepsy suggests that HRT can be initiated in certain women to achieve therapeutic benefits without adversely affecting seizure activity.
authors.affiliation: College of Pharmacy, Ohio State University, Columbus 43210, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Peebles
authors.forename: J W
authors.initials: JW
authors.lastname: McAuley
authors.forename: J L
authors.initials: JL
authors.lastname: Moore
authors.forename: H J
authors.initials: HJ
authors.lastname: Malone
authors.forename: A L
authors.initials: AL
authors.lastname: Reeves
mesh_terms: D004827:Epilepsy / Q000503:physiopathology*; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies; D016387:Women's Health
chemical_list: D004967:Estrogens