title: Functional properties of regenerating skeletal muscle following LIF administration.
abstract: We tested the hypothesis that periodic systemic administration of the myogenic cytokine leukemia inhibitory factor (LIF) enhances the functional recovery of regenerating skeletal muscle following bupivacaine-induced degeneration. LIF had no effect on functional capacity or regenerating myofiber size in rat muscles at 7, 14, or 21 days post-injury. The results do not support exogenous administration of LIF as a treatment for acute muscle injury, but a more frequent dosing regimen should be tested.
authors.affiliation: Department of Physiology, The University of Melbourne, Victoria 3010, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Gregorevic
authors.forename: A
authors.initials: A
authors.lastname: Hayes
authors.forename: G S
authors.initials: GS
authors.lastname: Lynch
authors.forename: D A
authors.initials: DA
authors.lastname: Williams
mesh_terms: D000818:Animals; D006131:Growth Inhibitors / Q000494:pharmacology*; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000503:physiopathology*; D009135:Muscular Diseases / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000187:drug effects* / Q000502:physiology*
chemical_list: D006131:Growth Inhibitors; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines