title: Hyperfluorescence associated with serous retinal pigment epithelial detachment on indocyanine green angiography.
abstract: OBJECTIVE
  Indocyanine green angiography has been reported to improve detection and delineation of occult choroidal neovascularisation in serous pigment epithelium detachment in age-related macular degeneration. The study aims to evaluate the visual acuity results of eyes affected by serous pigment epithelium detachment in age-related macular degeneration, having had indocyanine green-directed laser photocoagulation, and to correlate them to the pattern of serous pigment epithelium detachment on indocyanine green angiography.
  
  
  METHODS
  Thirty-four eyes of 31 patients affected by serous pigment epithelium detachment in age-related macular degeneration were prospectively considered. Each patient underwent an ophthalmological examination including fluorescein and indocyanine green angiography one day before, and 6 weeks, 3 months, 6 months, 9 months, 12 months and 24 months after krypton-laser treatment. The serous pigment epithelium detachment was classified in the late-phases angiograms as either hypofluorescent, isofluorescent or hyperfluorescent comparing the fluorescence of the serous pigment epithelium detachment with the choroidal background fluorescence.
  
  
  RESULTS
  The indocyanine green-guided laser treatment was associated with a temporary stabilization and a long-term progressive reduction of visual acuity: after 24 months visual acuity improved in 2.9%, stabilized in 26.5% and worsened in 70.5% of cases. Serous pigment epithelium detachment presenting a pretreatment hyperfluorescence had a final visual acuity of 0.06, with subfoveal choroidal neovascularisation development in 100% of cases, whereas serous pigment epithelium detachment presenting a pretreatment hypofluorescence and isofluorescence showed a final visual acuity of 0.12, with subfoveal choroidal neovascularisation development in 43.5% of eyes, with statistically significant difference.
  
  
  CONCLUSIONS
  Overall visual acuity decreases with time after indocyanine green-guided laser treatment of choroidal neovascularisation in serous pigment epithelium detachment, and serous pigment epithelium detachment becoming hyperfluorescent in the late-phases of indocyanine green angiography has the worst functional outcome.
authors.affiliation: Eye Clinic, University of Trieste, Ospedale Maggiore, Italy.
authors.forename: M B
authors.initials: MB
authors.lastname: Parodi
authors.forename: S
authors.initials: S
authors.lastname: Saviano
authors.forename: E
authors.initials: E
authors.lastname: Bondel
authors.forename: P
authors.initials: P
authors.lastname: Panetta
authors.forename: D
authors.initials: D
authors.lastname: Iustulin
authors.forename: S
authors.initials: S
authors.lastname: Fachin
authors.forename: G
authors.initials: G
authors.lastname: Ravalico
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D005451:Fluorescein Angiography; D005453:Fluorescence; D006801:Humans; D007208:Indocyanine Green; D017075:Laser Coagulation; D008268:Macular Degeneration / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D011446:Prospective Studies; D012163:Retinal Detachment / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D014792:Visual Acuity
chemical_list: D007208:Indocyanine Green