Diversity of alleles encoding HLA-B40: relative frequencies in united states populations and description of five novel alleles.
The frequency of each B*40 allele was determined by DNA sequencing in four major United States populations: Caucasians, African Americans, Asians/Pacific Islanders, and Hispanics. Thirty-two individuals from each ethnic group, who were previously described serologically as B40, B60, or B61, were randomly selected out of a pool of 82,979 unrelated individuals for allele characterization. Out of nine different B*40 alleles identified in this study, B*4001 and B*4002 were the two most frequent B*40 alleles in all the population groups. B*4001 was the primary B*40 allele seen in Caucasians (83%) and African Americans (76%), while B*4002 was found in the majority of Hispanics (62%). The distributions of both alleles were comparable in the Asian/Pacific Islander population. These two alleles were the only B*40 alleles detected in Caucasians while four to five additional B*40 alleles were seen in the other population groups. The other B*40 alleles detected in this study included: B*4003 and B*4010 in Asian/Pacific Islanders; B*4012 and B*4016 in African Americans; and B*4004, B*4006, and B*4027 in Hispanics. Analysis revealed significant differences between Hispanics and all other groups as well as between African Americans and Asian/Pacific Islanders. This report also describes five novel B*40 alleles: B*4019, B*4020, B*4024, B*4027, and B*4028.
Pimtanothai
N
N
Immunology Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Rizzuto
G A
GA
Slack
R
R
Steiner
N K
NK
Kosman
C A
CA
Jones
P F
PF
Koester
R
R
Ng
J
J
Hartzman
R J
RJ
Katovich Hurley
C
C
D000483:Alleles; D005787:Gene Frequency; D014644:Genetic Variation; D015235:HLA-B Antigens / Q000145:classification / Q000235:genetics*; D059947:HLA-B40 Antigen; D014481:United States
D015235:HLA-B Antigens; D059947:HLA-B40 Antigen; C081918:HLA-B60 antigen; C079077:HLA-B61 antigen