Hormones, growth factors and other plasma variables in relation to osteochondrosis.
Osteochondrosis (OC) is a multifactorial disorder with endocrinological dysfunction and mineral imbalance having a role in pathogenesis. The present study focused on a possible relationship between insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D (1,25(OH)2D), cortisol, copper, zinc, calcium, ionised calcium, magnesium and phosphorus and 5 different postmortem and radiographical osteochondrosis scores of hock and stifle joints in foals age 0-11 months. Osteochondrosis-positive foals showed a significantly lower IGF-I activity than osteochondrosis-negative foals. PTH, 1,25(OH)2D, cortisol, copper, zinc and calcium also showed significant differences between osteochondrosis-positive and osteochondrosis-negative foals.
Sloet van Oldruitenborgh-Ooste
Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Mol
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JA
Barneveld
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D000818:Animals; D000831:Animals, Newborn; D001947:Breeding; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood; D003300:Copper / Q000032:analysis / Q000097:blood; D005260:Female; D006133:Growth Substances / Q000097:blood*; D006614:Hindlimb; D006728:Hormones / Q000097:blood*; D006734:Horse Diseases / Q000097:blood*; D006736:Horses; D006854:Hydrocortisone / Q000097:blood; D007592:Joint Diseases / Q000097:blood / Q000662:veterinary*; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008274:Magnesium / Q000097:blood; D008297:Male; D010007:Osteochondritis / Q000097:blood / Q000662:veterinary*; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011897:Random Allocation; D013002:Somatomedins / Q000378:metabolism; D013154:Spleen / Q000737:chemistry; D013264:Stifle; D015032:Zinc / Q000032:analysis / Q000097:blood
D006133:Growth Substances; D006728:Hormones; D010281:Parathyroid Hormone; D013002:Somatomedins; D010758:Phosphorus; D003300:Copper; D002117:Calcitriol; D008274:Magnesium; D015032:Zinc; D002118:Calcium; D006854:Hydrocortisone