Effects of antitumor drugs on offspring.
The offspring of Wistar rats obtained from parents, one of which received platinum-containing drug Platidiam (cisplatin) or anthracycline antibiotics Doxorubicin and Farmorubicin was characterized by low viability (embryonic death increased 4-30-fold compared to control) and congenital malformations. The fetuses displayed pathology in internal organs and low ossification rates. Newborn rats are characterized by low survival rate and retarded physical development.
Gol'dberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Borovskaya
T G
TG
Poluektova
M E
ME
D000818:Animals; D000831:Animals, Newborn; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D015251:Epirubicin / Q000009:adverse effects; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D015251:Epirubicin; D004317:Doxorubicin; D002945:Cisplatin