The effects of single dose of methamphetamine on lipid peroxidation levels in the rat striatum and prefrontal cortex.
The administration of methamphetamine to experimental animals results in damage to dopaminergic neurons. In the present study, we demonstrated that a single dose (15 mg/kg) of methamphetamine results in production of oxidative stress as demonstrated by increased thiobarbituric acid reactive substances levels in the rat striatum and prefrontal cortex. In conclusion, the results of present study provide further evidence in support of the notion that oxidative stress may play an important role in the methamphetamine-induced neurotoxicity.
Açikgöz
O
O
Dokuz Eylül University, School of Medicine, Department of Physiology, Balçova, Izmir, 35340 Turkey. osman.acikgoz@deu.edu.tr
Gönenç
S
S
Kayatekin
B M
BM
Pekçetin
C
C
Uysal
N
N
Dayi
A
A
Semin
I
I
Güre
A
A
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D017392:Thiobarbituric Acid Reactive Substances; D008694:Methamphetamine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase