Rapid development of Epstein-Barr virus-associated Hodgkin's disease after cessation of foscarnet therapy in an HIV-infected patient.
Epidemiological features suggest a link between Hodgkin's disease (HD) and Epstein-Barr virus (EBV) infection. Indeed, EBV genome and expression of latent antigens can be found in Reed-Sternberg cells. In the majority of cases HD in HIV patients seems to be EBV-associated. We report on a 51-year-old HIV-infected patient in whom EBV-positive HD of mixed cellularity rapidly developed within one month after cessation of treatment with intravenous foscarnet.
Schramm
C
C
1st Department of Medicine, Johannes Gutenberg University, Mainz, Germany. schramm@mail.uni.mainz.de
Schlaak
J F
JF
Galle
P R
PR
D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D020031:Epstein-Barr Virus Infections / Q000209:etiology* / Q000517:prevention & control; D017245:Foscarnet / Q000008:administration & dosage / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006689:Hodgkin Disease / Q000209:etiology* / Q000517:prevention & control / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged
D000998:Antiviral Agents; D017245:Foscarnet