P18 tumor suppressor gene and progression of oligodendrogliomas to anaplasia.
P18INK4C is a good candidate to be the tumor suppressor gene involved in oligodendrogliomas on 1p32. Loss of heterozygosity on 1p, mutation(s), homozygous deletion(s), and expression of p18 in 30 oligodendroglial tumors were investigated. Loss of heterozygosity on 1p was found in 15 tumors. A p18 mutation was found at an recurrence of an anaplastic oligodendroglioma, but not in the primary, low-grade tumor. No homozygous deletions were found and p18 was expressed in all cases. These results show that p18 alteration is involved in tumor progression in a subset of oligodendrogliomas.
He
J
J
INSERM U495, Hôpital de la Salpêtrière, Paris, France.
Hoang-Xuan
K
K
Marie
Y
Y
Leuraud
P
P
Mokhtari
K
K
Kujas
M
M
Delattre
J Y
JY
Sanson
M
M
D000483:Alleles; D000708:Anaplasia / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor / Q000235:genetics; D019942:Genes, p16 / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity / Q000235:genetics; D009837:Oligodendroglioma / Q000235:genetics*; D016133:Polymerase Chain Reaction