title: Biotransformations with Rhizopus arrhizus and Geotrichum candidum for the preparation of (S)-atenolol and (S)-propranolol.
abstract: (+/-)-Atenolol/(+/-)-propranolol and their acetates were incubated with the fungus Rhizopus arrhizus and Geotrichum candidum separately for different time intervals to afford (S)-atenolol/(S)-propranolol in good optical yield. The time and pH for this biotransformation was optimised. The present biodegradations using Rhizopus arrhizus and Geotrichum candidum provides a simple and useful method to obtain (S)-atenolol and (S)-propranolol which are active enantiomers of the beta-adrenergic blockers.
authors.affiliation: Department of Chemistry, The Institute of Science, Mumbai, India.
authors.forename: S V
authors.initials: SV
authors.lastname: Damle
authors.forename: P N
authors.initials: PN
authors.lastname: Patil
authors.forename: M M
authors.initials: MM
authors.lastname: Salunkhe
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry* / Q000378:metabolism; D001262:Atenolol / Q000737:chemistry* / Q000378:metabolism; D001673:Biodegradation, Environmental; D001711:Biotransformation; D005848:Geotrichum / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation; D015394:Molecular Structure; D011433:Propranolol / Q000737:chemistry* / Q000378:metabolism; D012233:Rhizopus / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D011433:Propranolol