title: Impact of delayed repair and elective high-frequency oscillatory ventilation on survival of antenatally diagnosed congenital diaphragmatic hernia: first application of these strategies in the more "severe" subgroup of antenatally diagnosed newborns.
abstract: OBJECTIVE
  a) To analyze the influence of a new management strategy on the outcome of neonates with antenatally diagnosed congenital diaphragmatic hernia (CDH); b) to determine early prognosis respiratory factors with the new strategy.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Level III perinatal center.
  
  
  METHODS
  Between 1985 and 1997, 51 consecutive neonates with antenatally diagnosed CDH were admitted to our level III neonatal intensive care unit. Before 1992 (period 1; n = 19), we used conventional mechanical ventilation and early surgery requiring transfer. Since 1992 (period 2; n = 32), we prospectively tested a new approach including (a) systematically use of high-frequency oscillatory ventilation (HFOV) regardless of the initial clinical severity, (b) delayed surgery following stabilization requiring transfer to a different surgical unit, but (c) no transfer of unstable patients with surgery under HFOV in our neonatal intensive care unit (n = 10). The two cohorts were comparable in terms of potential ante and postnatal prognostic indicators.
  
  
  RESULTS
  Survival was improved with the new strategy: 21/32 (66%) vs. 5/19 (26%); P < 0.02. This improvement between periods 1 and 2 was due to a decrease in both preoperative and postoperative deaths in the later period. The better survival during period 2 was associated with the appearance of very late deaths, frequent pleural effusions, and the survival of more severe forms having evolved to a chronic respiratory insufficiency. Survivors were ventilated for longer time with longer duration of oxygen supplementation. The best oxygenation index (OI), alveolar arterial difference and oscillation amplitude (P/P) during the first 24 h, but not the best PaCO2, were the most reliable prognostic indicators during period 2. An OI < or = 10 with a P/P < or = 55 cmH2O was associated with a very good prognosis (94% survival).
  
  
  CONCLUSIONS
  The prognosis of antenatally diagnosed CDH was improved by systematic HFOV on admission, no systematic transfer, and delayed surgery. This improvement is associated with modification of postnatal outcome.
authors.affiliation: Services de Médicine Néonatale, UFR Cochin-Port Royal, Paris, France. luc.desfrere@cch.ap-hop-paris.fr
authors.forename: L
authors.initials: L
authors.lastname: Desfrere
authors.forename: P H
authors.initials: PH
authors.lastname: Jarreau
authors.forename: M
authors.initials: M
authors.lastname: Dommergues
authors.forename: A
authors.initials: A
authors.lastname: Brunhes
authors.forename: P
authors.initials: P
authors.lastname: Hubert
authors.forename: C
authors.initials: C
authors.lastname: Nihoul-Fekete
authors.forename: P
authors.initials: P
authors.lastname: Mussat
authors.forename: G
authors.initials: G
authors.lastname: Moriette
mesh_terms: D005260:Female; D006548:Hernia, Diaphragmatic / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D065630:Hernias, Diaphragmatic, Congenital; D006612:High-Frequency Ventilation; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011379:Prognosis; D012372:ROC Curve; D015656:Respiratory Mechanics; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome