L- and M-cone driven ERGs are differently altered in Best's macular dystrophy.
To study the L- and M-cone pathways and their interactions in patients with Best's macular dystrophy (BMD), ERG response thresholds were measured to stimuli which modulated exclusively the L- or the M-cones, or both in various combinations. The ERG threshold data could be described with a vector addition model. Compared with normals, BMD patients showed generally larger amplitudes of the L-cone driven ERGs. However, the M-cone driven ERGs were similar in amplitude but significantly phase advanced. The data confirm our previous observations that L- and M-cone pathways can be affected differently by retinal degeneration, despite their large physiological and biochemical similarities.
Scholl
H P
HP
University Eye Hospital, Schleichstr. 12-16, 72076, Tübingen, Germany.
Kremers
J
J
Apfelstedt-Sylla
E
E
Zrenner
E
E
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004596:Electroretinography; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008268:Macular Degeneration / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology*; D014795:Visual Pathways / Q000502:physiology