Peptic ulcer inheritance in patients with elevated serum pepsinogen group A levels and without infection of Helicobacter pylori.
BACKGROUND
Peptic ulcer has multifactorial aetiology, including genetic factors. We have identified a family with pepsinogen Group A levels higher than normal, with a high prevalence of ulcer disease and a low prevalence of Helicobacter pylori infection.


OBJECTIVE
Performing linkage analysis in the identified family


METHODS
We examined the segregation of pepsinogens with microsatellite dinucleotide repeat DNA markers along chromosome 11 (D11S480, PYGM) for pepsinogen Group A and along chromosome 6 [D6S105, D6S 1610, TRMI) for pepsinogen Group C.


RESULTS
In markers examined along chromosome 11, linkage analysis provided no evidence for significant causal mutation but, controlling for some risk factors we observed that the probability of falling ill, increases. The linkage analysis along chromosome 6 for pepsinogen Group C did not show a uniform genetic profile.


CONCLUSIONS
This study evaluates the hypothesis of peptic ulcer inheritance at least in a small group of patients without the common risk factors.
Del Bianco
T
T
Gastroenterology Unit, University of Padua, Italy. tdelbian@tin.it
Borgoni
R
R
Del Bianco
P
P
Cedaro
P
P
Vianello
F
F
Danieli
G A
GA
Di Mario
F
F
D000907:Antibodies, Bacterial / Q000032:analysis; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D004247:DNA / Q000032:analysis*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology / Q000235:genetics / Q000382:microbiology*; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D010375:Pedigree; D020116:Pepsinogen A / Q000097:blood* / Q000235:genetics; D020115:Pepsinogen C / Q000097:blood / Q000235:genetics; D010437:Peptic Ulcer / Q000097:blood / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology; D016133:Polymerase Chain Reaction
D000907:Antibodies, Bacterial; D020115:Pepsinogen C; D020116:Pepsinogen A; D004247:DNA