Stability constants of potent cytotoxic copper(II) complexes with furan semicarbazones in ethanolic solutions.
Potent cytotoxic copper(II) complexes of furannic semicarbazones were studied in ethanolic solutions at 25 degrees C. The four ligands used were synthesized in our laboratory, i.e. 2-furfural semicarbazone (FSC), 5-methyl 2-furfural semicarbazone (MFSC), 2-furfural 4-phenyl semicarbazone (FPSC) and 3-(2-furyl) prop-2-enal semicarbazone (FASC). The mathematical analysis was carried out with a recent computer program SIRKO which indicated the formation of one metal-ligand complex in each case and the logarithm of their stability constants are: log beta=2.02, 3.84, 4.58 and 4.52 for ligands FSC, MFSC, FASC and FPSC, respectively. A relation between stability and molecular weight of the ligands is proposed which may prove to be interesting as these complexes are being investigated for their cytotoxic activities.
Ibrahim
G
G
Université Libanaise, Ramlé El-Baïda, Beyrouth, Lebanon.
Bouet
G M
GM
Hall
I H
IH
Khan
M A
MA
D003300:Copper; D003603:Cytotoxins / Q000737:chemistry*; D004355:Drug Stability; D000431:Ethanol; D009942:Organometallic Compounds / Q000737:chemistry*; D012664:Semicarbazones; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet
D003603:Cytotoxins; D009942:Organometallic Compounds; D012664:Semicarbazones; D012996:Solutions; D000431:Ethanol; D003300:Copper