title: Interleukin 18 (IL-18) levels in patients with sepsis.
abstract: IL-18 levels in the blood of 13 sepsis patients were assessed. The IL-18 values were significantly correlated with their Acute Physiology and Chronic Health Evaluation (APACHE) II scores, and they were a good reflection of the severity of the disease. There was also a strong correlation between the IL-18 values and the patients' inflammatory cytokine levels. The results suggested strong involvement of IL-18 in the pathogenesis of sepsis.
authors.affiliation: Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Endo
authors.forename: K
authors.initials: K
authors.lastname: Inada
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: G
authors.initials: G
authors.lastname: Wakabayashi
authors.forename: H
authors.initials: H
authors.lastname: Ishikura
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Sato
mesh_terms: D018806:APACHE; D002056:Burns / Q000473:pathology; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D020382:Interleukin-18; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha