title: Glucose transporter 1 (GLUT1) expression is associated with intestinal type of gastric carcinoma.
abstract: Increased expression of glucose transporter1 (GLUT1) has been reported in many human cancers. We hypothesized that the degree of GLUT1 might provide a useful biological information in gastric adenocarcinoma. RT-PCR and immunostaining were used to analyze GLUT1 expression in gastric cancer. RT-PCR showed GLUT1 expression was not largely detected in normal gastric tissue but was detected in cancerous gastric tissue of counterpart. By immunohistochemistry, GLUT1 protein was absent in normal gastric epithelium and intestinal metaplasia. 11 of 65 patients with gastric adenocarcinoma had specific GLUT1 immunostaining in a plasma membrane pattern with varied intensities. GLUT1 protein did not show any significant correlation with tumor stage and nodal metastasis (p>0.05 by Mann-Whitney test). However, the positive immunostaining for GLUT1 is associated with intestinal differentiation (p=0.003). Our results suggest that GLUT1 protein is associated with intestinal type of gastric cancer.
authors.affiliation: Division of Cancer Research, National Institute of Health, Seoul, Korea.
authors.forename: W S
authors.initials: WS
authors.lastname: Kim
authors.forename: Y Y
authors.initials: YY
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Jang
authors.forename: K
authors.initials: K
authors.lastname: Kimm
authors.forename: M H
authors.initials: MH
authors.lastname: Jung
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry* / Q000473:pathology; D051272:Glucose Transporter Type 1; D006801:Humans; D007422:Intestines; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009004:Monosaccharide Transport Proteins / Q000032:analysis*; D009363:Neoplasm Proteins / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; D009363:Neoplasm Proteins; C495677:SLC2A1 protein, human