Detection of herpes simplex virus type 1 in human vestibular nuclei.
The distribution of herpes simplex virus type 1 (HSV-1) in human geniculate, vestibular ganglia, and vestibular nuclei was determined in 10 human temporal bones and brainstems of five individuals by PCR. HSV-1 was found in 3 of 10 of each ganglia and vestibular nuclei. The various patterns of HSV-1 infection of vestibular structures are compatible with virus migration from the vestibular ganglia to the vestibular nuclei and from the ipsilateral to the contralateral vestibular nucleus via commissural fibers.
Arbusow
V
V
Department of Neurology, Klinikum Grobetahadern, University of Munich, Munich, Germany. varbusow@nro.med.uni-muenchen.de
Strupp
M
M
Wasicky
R
R
Horn
A K
AK
Schulz
P
P
Brandt
T
T
D000328:Adult; D000368:Aged; D005260:Female; D006561:Herpes Simplex / Q000473:pathology* / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014726:Vestibular Nuclei / Q000821:virology*