title: Granulocyte colony-stimulating factor-producing small-cell carcinoma of the uterine cervix: report of a case.
abstract: A case of granulocyte colony-stimulating factor (G-CSF)-producing small-cell carcinoma of the uterine cervix is described. In a 70-yr-old woman, clusters of small cells with hyperchromatic nuclei at a high nuclear/cytoplasmic ratio were detected cytologically in the cervix. These clusters were diagnosed as a small-cell neuroendocrine carcinoma by the concomitant use of Grimelius staining and immunohistochemical staining, in addition to electron microscopic observation. This patient showed a significant increase in peripheral leukocytes, despite the absence of infectious signs. Immunohistochemical findings, together with a high blood G-CSF level, suggested the production of G-CSF from the tumor. Consistent with the knowledge that both small-cell carcinoma and G-CSF-producing tumors have a poor prognoses, the patient had no or partial response to therapies performed, and died from the cancer 11 mo after it was diagnosed. This case strongly indicates the need for early diagnosis of this type of tumor, based on cytological features.
authors.affiliation: Department of Obstetrics and Gynecology, Jikei University School of Medicine Aoto Hospital, Tokyo, Japan. wtnb-khk@dd.iij4u.or.jp
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Wachi
authors.forename: H
authors.initials: H
authors.lastname: Omi
authors.forename: H
authors.initials: H
authors.lastname: Nishii
authors.forename: K
authors.initials: K
authors.lastname: Ochiai
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Endo
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology*; D002584:Cervix Uteri / Q000737:chemistry / Q000473:pathology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor