title: Use of proline bioisosteres in potential HIV protease inhibitors: phenylalanine-2-thiophenoxy-3-pyrrolidinone: synthesis and anti-HIV evaluation.
abstract: The synthesis of new phenylalanine-2-thiophenoxy-3-pyrrolidinones is described. Anti-HIV recombinant protease assays and HIV infected cell culture assays (observation of syncytia) demonstrated the potent anti-HIV activity of this new class of pseudopeptides.
authors.affiliation: Laboratoire de Chimie Biomoleculaire, Faculté des Sciences de Luminy, Université de la Méditerranée, Marseille, France. kraus@luminy.univ-mrs.fr
authors.forename: J L
authors.initials: JL
authors.lastname: Kraus
authors.forename: M
authors.initials: M
authors.lastname: Bouygues
authors.forename: J
authors.initials: J
authors.lastname: Courcambeck
authors.forename: J C
authors.initials: JC
authors.lastname: Chermann
mesh_terms: D015374:Biosensing Techniques; D002460:Cell Line; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011392:Proline; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D017320:HIV Protease Inhibitors; D011760:Pyrrolidinones; D011392:Proline