Opposite effects of feeding a vitamin A-deficient diet and retinoic acid treatment on brown adipose tissue uncoupling protein 1 (UCP1), UCP2 and leptin expression.
The relationship between interscapular brown adipose tissue (IBAT) thermogenic potential and vitamin A status was investigated by studying the effects of feeding a vitamin A-deficient diet and all-trans retinoic acid (tRA) treatment on body weight and IBAT parameters in mice. Feeding a vitamin A-deficient diet tended to trigger opposite effects to those of tRA treatment, namely increased body weight, IBAT weight, adiposity and leptin mRNA expression, and reduced IBAT thermogenic potential in terms of uncoupling protein 1 (UCP1) mRNA and UCP2 mRNA expression. The results emphasize the importance of retinoids as physiological regulators of brown adipose tissue.
Bonet
M L
ML
Laboratori de Biologia Molecular, Nutrició i Biotecnologia, Departamento Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Crta. Valldemossa Km 7.5, 07071 Palma de Mallorca, Spain.
Oliver
J
J
Picó
C
C
Felipe
F
F
Ribot
J
J
Cinti
S
S
Palou
A
A
D002001:Adipose Tissue, Brown / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D015152:Blotting, Northern; D001833:Body Temperature Regulation; D001835:Body Weight; D002352:Carrier Proteins / Q000378:metabolism*; D006984:Hypertrophy; D007473:Ion Channels; D020738:Leptin / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D051379:Mice; D008815:Mice, Inbred Strains; D024101:Mitochondrial Proteins; D011506:Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D014212:Tretinoin / Q000008:administration & dosage*; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D014802:Vitamin A Deficiency / Q000378:metabolism* / Q000473:pathology
D002352:Carrier Proteins; D007473:Ion Channels; D020738:Leptin; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; D012333:RNA, Messenger; C000604372:Ucp1 protein, mouse; C000604390:Ucp2 protein, mouse; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D014212:Tretinoin