title: Human circulatory system model based on Frank's mechanism.
abstract: A new analytical model of the left ventricle as a pump, developed from isolated canine experiments, was adapted to describe each of the four heart chambers in a complete human circulatory system model. Each chamber is embodied as a volume and time dependent isovolumic pressure source, after Otto Frank's classic experiments. Analytical results show that a small set of equations is sufficient to describe the main features of the heart as a pump, including isovolumic and ejecting beats for a wide range of ventricular and circulation conditions. This model allows interactive teaching of cardiovascular system dynamics. Computed results demonstrate that, with additional experiments, a quantitative description of the human circulation for research purposes may emerge from this approach.
authors.affiliation: Department of Engineering, Trinity College, Hartford, CT, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Palladino
authors.forename: L C
authors.initials: LC
authors.lastname: Ribeiro
authors.forename: A
authors.initials: A
authors.lastname: Noordergraaf
mesh_terms: D000818:Animals; D004285:Dogs; D006801:Humans; D008433:Mathematics; D008955:Models, Cardiovascular; D013318:Stroke Volume / Q000502:physiology*; D016276:Ventricular Function; D017725:Ventricular Pressure / Q000502:physiology