High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients.
Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin-6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with human herpesvirus 8 (HHV8) infection. In a prospective study of 23 HIV-infected patients with MCD, clinical symptoms of MCD were present at 45 visits, whereas patients were in chemotherapy-induced clinical remission at 50 visits. Symptoms were associated with a high level of serum C reactive protein, high HHV8 viral load in peripheral blood mononuclear cells, and high plasma human IL-6 and IL-10 levels. Strong correlations between plasma IL-6 and plasma IL-10 with the HHV8 viral load suggest that both cytokines may be involved in the pathogenesis of this virus-associated lymphoproliferative disorder.
Oksenhendler
E
E
Department of Immunology and Hematology, Laboratory of Virology, Hôpital Saint-Louis, Paris, France. oksenhendler@chu-stlouis.fr
Carcelain
G
G
Aoki
Y
Y
Boulanger
E
E
Maillard
A
A
Clauvel
J P
JP
Agbalika
F
F
D000328:Adult; D000368:Aged; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism*; D005871:Castleman Disease / Q000097:blood* / Q000209:etiology / Q000821:virology*; D015658:HIV Infections / Q000150:complications*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D019562:Viral Load
D015415:Biomarkers; D015850:Interleukin-6; D016753:Interleukin-10; D002097:C-Reactive Protein