Bioactive sesquiterpenes from the basidiomycete Resupinatus leightonii.
1(10),4-Germacradiene-2,6,12-triol (1), a new germacrane sesquiterpene, and 1,6-farnesadiene-3,10,11-triol (2), a known nerolidol derivative, were isolated from submerged cultures of the basidiomycete Resupinatus leightonii. Both compounds inhibited cAMP-induced appressorium formation in Magnaporthe grisea and showed cytotoxic activity. The structure of 1 was determined by NMR and mass spectroscopic methods.
Eilbert
F
F
Institute for Biotechnology and Drug Research (IBWF e.V.), D-67663 Kaiserslautern, Germany.
Engler-Lohr
M
M
Anke
H
H
Sterner
O
O
D000363:Agaricales / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D020082:Magnaporthe / Q000187:drug effects; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013057:Spectrum Analysis
D012717:Sesquiterpenes