An answer to a complex problem: cloning the mouse t-complex responder.
The t-complex is maintained in wild mouse populations by its high transmission (up to 99%) from heterozygous males and provides an example of "meiotic drive". Its molecular basis has remained obscure despite long and intensive study. In a major advance, the t-complex responder gene, thought to be the key gene on which several distorters act, has now been cloned.
Lyon
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MF
MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire OX11 0RD, UK.
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D003001:Cloning, Molecular; D005544:Forecasting; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases; D056427:t-Complex Genome Region
D047908:Intracellular Signaling Peptides and Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; C116196:PPP1R11 protein, human; D044767:Ubiquitin-Protein Ligases