Common polymorphism in the promoter of the CD14 monocyte receptor gene is associated with acute myocardial infarction in Japanese men.
We investigated whether C(-260)-->T polymorphism in the promoter of the CD14 monocyte receptor gene predisposed to coronary atherosclerosis and acute myocardial infarction (AMI) in Japanese men. The frequencies of T allele and T/T homozygotes in patients with AMI were significantly higher than in controls and in patients with angina without prior AMI, suggesting that the CD14 promoter polymorphism is associated with AMI rather than with coronary atherosclerosis, and this polymorphism may be one of the genetic risk factors for AMI in Japanese men.
Shimada
K
K
Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan. shimakaz@med.juntendo.ac.jp
Watanabe
Y
Y
Mokuno
H
H
Iwama
Y
Y
Daida
H
H
Yamaguchi
H
H
D000368:Aged; D000483:Alleles; D004562:Electrocardiography; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D018950:Lipopolysaccharide Receptors / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000378:metabolism*
D005819:Genetic Markers; D018950:Lipopolysaccharide Receptors