Structure of the infected cell protein 0 gene of canine herpesvirus.
The canine herpesvirus infected cell protein 0 (CICP0) gene was sequenced. The CICP0 gene was transcribed as a 1.4 kb mRNA from the end of the unique long region nearby the internal repeat during early phase of productive infection of the virus. An open reading frame of the gene encodes a polypeptide of 333 amino acids. The RING finger domain and acidic transcriptional activation domain were found at the N-terminus and within the middle region in the deduced amino acid sequence, respectively, suggesting that the CICP0, like the ICP0 of herpes simplex virus 1, is a transactivating protein.
Miyoshi
M
M
Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Takiguchi
M
M
Yasuda
J
J
Hashimoto
A
A
Takada
A
A
Okazaki
K
K
Kida
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002460:Cell Line; D016384:Consensus Sequence; D017931:DNA Primers; D004279:DNA, Viral / Q000235:genetics*; D004285:Dogs; D002184:Herpesvirus 1, Canid / Q000737:chemistry / Q000235:genetics*; D017874:Immediate-Early Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012333:RNA, Messenger / Q000032:analysis; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015534:Trans-Activators / Q000235:genetics; D044767:Ubiquitin-Protein Ligases
D017931:DNA Primers; D004279:DNA, Viral; D017874:Immediate-Early Proteins; D012333:RNA, Messenger; D015534:Trans-Activators; D044767:Ubiquitin-Protein Ligases; C051804:Vmw110 protein, Human herpesvirus 1