title: Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk.
abstract: Plasma levels of alpha1-antichymotrypsin (ACT) and interleukin-1beta (IL-1beta) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-1beta genes affected plasma levels of ACT or IL-1beta, and AD patients with the ACT T,T or IL-1beta T,T genotype showed the highest levels of plasma ACT or IL-1beta, respectively. The concomitant presence of the ACT T,T and IL-1beta T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease.
authors.affiliation: Dipartimento di Patologia Sperimentale, School of Medicine, University of Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Licastro
authors.forename: S
authors.initials: S
authors.lastname: Pedrini
authors.forename: C
authors.initials: C
authors.lastname: Ferri
authors.forename: V
authors.initials: V
authors.lastname: Casadei
authors.forename: M
authors.initials: M
authors.lastname: Govoni
authors.forename: A
authors.initials: A
authors.lastname: Pession
authors.forename: F L
authors.initials: FL
authors.lastname: Sciacca
authors.forename: F
authors.initials: F
authors.lastname: Veglia
authors.forename: G
authors.initials: G
authors.lastname: Annoni
authors.forename: M
authors.initials: M
authors.lastname: Bonafè
authors.forename: F
authors.initials: F
authors.lastname: Olivieri
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
authors.forename: L M
authors.initials: LM
authors.lastname: Grimaldi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics*; D000704:Analysis of Variance; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D000514:alpha 1-Antichymotrypsin / Q000097:blood* / Q000235:genetics*
chemical_list: D007375:Interleukin-1; D000514:alpha 1-Antichymotrypsin