title: Eggplant (Solanum melongena) infusion has a modest and transitory effect on hypercholesterolemic subjects.
abstract: Eggplant (Solanum melongena) is consumed extensively in Brazil. It has been believed that infusion of a powdered preparation of the fruit may reduce serum cholesterol. However, there are few documented reports on its effects on cholesterol metabolism and its possible hypocholesterolemic effect has not been proved by well-controlled studies. The aim of the present study was to observe the effects of S. melongena on the serum cholesterol and triglycerides of 38 hypercholesterolemic human volunteers ingesting S. melongena infusion for five weeks. Thirty-eight hypercholesterolemic subjects receiving either S. melongena infusion (N = 19) or placebo (N = 19) participated in two clinical experiments in which the effect of S. melongena infusion was studied with (N = 16) or without (N = 38) dietary orientation. Total cholesterol and its fractions, triglycerides, and apolipoproteins A and B were measured in blood at the beginning of the experiment and three and five weeks thereafter. No differences were observed compared to control. Intraindividual analysis showed that S. melongena infusion significantly reduced the blood levels of total and LDL cholesterol and of apolipoprotein B. After dietary orientation, no intra- or intergroup differences were seen for any of the parameters analyzed. The results suggest that S. melongena infusion had a modest and transitory effect, which was not different from that obtained with standard orientation for dyslipidemia patients (diet and physical activities).
authors.affiliation: Laboratório de Nutrição e Gnotobiologia, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Belo Horizonte, MG, Brasil.
authors.forename: P R
authors.initials: PR
authors.lastname: Guimarães
authors.forename: A M
authors.initials: AM
authors.lastname: Galvão
authors.forename: C M
authors.initials: CM
authors.lastname: Batista
authors.forename: G S
authors.initials: GS
authors.lastname: Azevedo
authors.forename: R D
authors.initials: RD
authors.lastname: Oliveira
authors.forename: R P
authors.initials: RP
authors.lastname: Lamounier
authors.forename: N
authors.initials: N
authors.lastname: Freire
authors.forename: A M
authors.initials: AM
authors.lastname: Barros
authors.forename: E
authors.initials: E
authors.lastname: Sakurai
authors.forename: J P
authors.initials: JP
authors.lastname: Oliveira
authors.forename: E C
authors.initials: EC
authors.lastname: Vieira
authors.forename: J I
authors.initials: JI
authors.lastname: Alvarez-Leite
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*; D014675:Vegetables / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol