The genotype of human transcription factor AP-2beta is associated with platelet monoamine oxidase B activity.
Platelet monoamine oxidase B (MAO; EC 1.4.3.4.) activity is stable in the individual and is mainly genetically regulated. Levels of MAO-B in platelets have repeatedly been shown to be associated with personality traits. We have recently also demonstrated an association between the genotype of AP-2beta to a variety of personality traits as well as binge-eating disorder. In the present study we have analysed blood samples from 158 males and 64 females with regard to platelet MAO activity and genotype of transcription factor AP-2beta. In both sexes homozygotes for the long allele [CAAA](5) were significantly associated with low platelet MAO activity P<0.0001 (males) and P=0.0158 (females). This study represents a novel approach to increase the understanding about the molecular mechanisms for how the MAOB gene is regulated in blood cells and how this regulation is linked to personality traits.
Damberg
M
M
Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden.
Garpenstrand
H
H
Berggârd
C
C
Asberg
M
M
Hallman
J
J
Oreland
L
L
D000483:Alleles; D000704:Analysis of Variance; D001792:Blood Platelets / Q000201:enzymology*; D002032:Bulimia / Q000201:enzymology / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D012737:Sex Factors; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D008995:Monoamine Oxidase