Perspectives for vascular genomics.
Diseases of the vascular system result from a complex mixture of genetic and environmental factors. Data sets, technologies and strategies emanating from the human genome programme have been applied to the analysis of both rare single-gene and common multigenic vascular disorders. Genomic approaches including inter- and intraspecies sequence comparisons, genotyping with dense marker sets spanning the genome, large-scale mutagenesis screens of model organisms, and genome-wide expression profiling have all begun to contribute to the identification of new genes and mechanisms that are central to cardiovascular disease processes.
Rubin
E M
EM
Lawrence Berkeley National Laboratory, Genome Sciences Department, Berkeley, California 94720, USA. emrubin@lbl.gov
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D000818:Animals; D002318:Cardiovascular Diseases / Q000235:genetics*; D002320:Cardiovascular Physiological Phenomena; D005544:Forecasting; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D015894:Genome, Human; D006801:Humans; D016296:Mutagenesis; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA