title: Magnetic resonance spectroscopy of tubers in patients with tuberous sclerosis.
abstract: OBJECTIVE
  The histological features of cortical tubers in patients with tuberous sclerosis (TS) were studied by the proton magnetic resonance spectroscopy (MRS).
  
  
  METHODS
  The subjects were 4 children, mean age of 10 years, with clear evidence of tubers on MRI and SPECT. Four age-matched control children served as control subjects. Spectra were acquired over the tuber using short TE.
  
  
  RESULTS
  The myoinositol/creatine ratios in the tubers of TS patients were significantly increased compared with those of the control subjects (P < 0.02). The NAA/creatine ratios in the tubers of patients were significantly decreased (P < 0.02).
  
  
  CONCLUSIONS
  The decrease of NAA/creatine ratios in the tubers of patients was considered to reflect a reduction of cranial neurons. The increase of myoinositol/creatine ratios in the tubers was thought to reflect an increase of glial cells. Proton MRS might play a role in estimation of histological changes in the neurological diseases.
authors.affiliation: Department of Radiology, Gifu University School of Medicine, Japan. shinji@cc.gifu-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Mizuno
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Z
authors.initials: Z
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Hoshi
mesh_terms: D000328:Adult; D000367:Age Factors; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003401:Creatine / Q000378:metabolism*; D018450:Disease Progression; D004827:Epilepsy / Q000209:etiology; D005260:Female; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon; D014402:Tuberous Sclerosis / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*
chemical_list: D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine