title: Prolonged cold ischemia time obviates the benefits of 0 HLA mismatches in renal transplantation.
abstract: OBJECTIVE
  Recipients of 0 HLA mismatch kidneys with prolonged cold ischemia times of longer than 36 hours do not have superior outcomes compared with recipients of kidneys with 1 or more mismatches.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  Transplanation centers.
  
  
  METHODS
  A total of 63,688 recipients who underwent transplantation between January 1, 1990, and July 31, 1998.
  
  
  METHODS
  Delayed graft function, serum creatinine level, and patient and renal graft survival.
  
  
  RESULTS
  Recipients of 0 HLA mismatch kidneys with fewer than 36 hours of cold ischemia time had better 5-year graft survival (75%) when compared with recipients with 1 or more mismatches (67%) (P<.001). However, recipients of 0 HLA mismatch kidneys with longer than 36 hours of cold ischemia time did not have any graft survival advantage (71% in 0 HLA mismatch kidneys vs 72% in 1 or more mismatches, P =.24).
  
  
  CONCLUSIONS
  Cold ischemia times of longer than 36 hours obviate the benefits of better graft survival conferred by better matching.
authors.affiliation: Division of Transplantation, Department of Surgery, Box 0780, University of California-San Francisco, 513 Parnasus Ave, San Francisco, CA 94143-0780, USA. robertsj@surgery.ucsf.edu
authors.forename: C M
authors.initials: CM
authors.lastname: Lee
authors.forename: J T
authors.initials: JT
authors.lastname: Carter
authors.forename: E J
authors.initials: EJ
authors.lastname: Alfrey
authors.forename: N L
authors.initials: NL
authors.lastname: Ascher
authors.forename: J P
authors.initials: JP
authors.lastname: Roberts
authors.forename: C E
authors.initials: CE
authors.lastname: Freise
mesh_terms: D001788:Blood Grouping and Crossmatching; D002314:Cardioplegic Solutions; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D009926:Organ Preservation; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D002314:Cardioplegic Solutions