Synthesis and immunomodulating activity of 5H-thiazolo[2,3-b]quinazolin-3(2H)-one.
The synthesis and immunomodulating activity of 5H-thiazolo[2,3-b]quinazoline-3(2H)-one (7) are described. When tested in the Kennedy plaque assay, 7 exerted immunosuppressive activity on IgM production in female C3H mice sensitized with sheep erythrocytes.
Bennett
G A
GA
Department of Organic Chemistry, Pennwalt Corporation, Rochester, NY 14623, USA.
Radov
L A
LA
Trusso
L A
LA
Georgiev
V S
VS
D000818:Animals; D005260:Female; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008809:Mice, Inbred C3H; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
C414045:5H-thiazolo(2,3-b)quinazolin-3(2H)-one; D007166:Immunosuppressive Agents; D011799:Quinazolines; D013844:Thiazoles