title: Collagenolytic protease preparations from invertebrates: experimental study of acute and chronic toxicity.
abstract: Toxicity of active matter of new structure-destroying enzyme preparations containing a complex of collagenolytic proteases from invertebrates (Collagenase from hydrobionts, Polycollagenase-K, Fermenkol) was studied. The absence of acute toxicity in skin application is proved, and LD(50) for intraperitoneal administration to mice and rats were determined. A long-term treatment with clinical doses under various types of application does not affect body weight gain, biochemical indices of the plasma, ECG, diuresis, and urine content.
authors.affiliation: St. Petersburg-Technologiya, St. Petersburg.
authors.forename: B A
authors.initials: BA
authors.lastname: Paramonov
authors.forename: O A
authors.initials: OA
authors.lastname: Klimova
authors.forename: V Y
authors.initials: VY
authors.lastname: Chebotarev
mesh_terms: D000818:Animals; D017364:Collagenases / Q000302:isolation & purification* / Q000378:metabolism / Q000633:toxicity; D007448:Invertebrates; D008297:Male; D051379:Mice
chemical_list: D017364:Collagenases