Free radical formation and toxicity in the limb teratogenicity of L-NAME: a new mechanistic model of vascular disruption.
Fantel
A G
AG
Department of Pediatrics, University of Washington, Birth Defects Laboratory, Seattle, Washington 98195-6320, USA. agf@u.washington.edu
Stamps
L D
LD
Tran
T T
TT
Mackler
B
B
Person
R E
RE
Nekahi
N
N
D001808:Blood Vessels / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000633:toxicity*; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D017880:Limb Deformities, Congenital / Q000139:chemically induced* / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000633:toxicity*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D052250:Nitric Oxide Synthase Type III
D004791:Enzyme Inhibitors; D005609:Free Radicals; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; D019331:NG-Nitroarginine Methyl Ester