Adrenergic and cholinergic mechanisms of hemopoiesis regulation during experimental neuroses.
Scopolamine abolished hyperplasia of erythropoiesis caused by conflict situation and its inhibition after paradoxical sleep deprivation, but did not affect granulomonocytopoiesis. The modulatory effects of this muscarinic receptor blocker on the erythron indicated involvement of the cholinergic system in the formation of neurotransmitter interrelations. In vitro restoration of the colony-forming ability of myelokaryocytes under the effect of sympathomimetics during in vivo blockade of the central or peripheral part of the adrenergic system indicated that adrenoceptors play the major role in the information transfer from the higher regulatory centers to hemopoietic cells.
Gol'dberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Dygai
A M
AM
Skurikhin
E G
EG
Provalova
N V
NV
Suslov
N I
NI
D000222:Adaptation, Physiological; D000818:Animals; D006410:Hematopoiesis / Q000502:physiology*; D051379:Mice; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009497:Neurotic Disorders / Q000503:physiopathology*; D011941:Receptors, Adrenergic / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology
D018727:Muscarinic Antagonists; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D012601:Scopolamine