title: New directions in systemic therapy of pancreatic cancer.
abstract: BACKGROUND
  The aggressiveness of pancreatic adenocarcinoma makes it a deadly disease, with its incidence rate and fatality rate almost equal. Surgery represents the only means to provide cure to patients with pancreatic cancer, though the 5-year survival is less than 10%.
  
  
  METHODS
  We review the data on surgical and systemic therapies and provide more details on a newer biologically based medical approach.
  
  
  RESULTS
  Neoadjuvant chemotherapy protocols are confined to one or two institutions, and adjuvant chemotherapy and chemoradiation therapy protocols are far from being standardized. Chemoradiation therapy for locally advanced pancreatic cancer offers limited benefits. Protocols that include gemcitabine and 5-fluorouracil, while comparing favorably to historical controls, offer median survivals at approximately 8 months.
  
  
  CONCLUSIONS
  More effective protocols with combinations of approaches agents are needed to improve the treatment of pancreatic cancer.
authors.affiliation: Center for Digestive Disorders, University of South Florida, Tampa, FL, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Rosemurgy
authors.forename: F M
authors.initials: FM
authors.lastname: Serafini
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000628:therapy*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis