[Expression of VEGF, KDR, p53, E6 HPV16 and HPV18 in vulvar and cervix cancer].
The aim of the study was a comparison of expression of angiogenesis genes: vascular endothelial growth factor (VEGF), KDR, suppressor gene p53, E6-HPV16 and HPV18, in tissue samples of normal, dystrophic, lymph nodes and malignant cancers of vulva and uterine cervix. The results demonstrate that molecular diagnostics of cancers using gene expression profiling indicates the definitive difference in expression profiles of aforementioned genes in tissues of the same malignancy.
Michalski
B
B
Katedry i Oddziału Klinicznego, Połoznictwa i Ginekologii w Tychach. bogdan.michalski@proloc.com.pl
Mazurek
U
U
Olejek
A
A
Kuśmierz
D
D
Poreba
R
R
Witek
A
A
Wilczok
T
T
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D015344:DNA Probes, HPV / Q000235:genetics; D016228:Endothelial Growth Factors / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D015513:Oncogene Proteins / Q000235:genetics*; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000235:genetics / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D014412:Tumor Virus Infections / Q000235:genetics / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000821:virology*; D014846:Vulvar Neoplasms / Q000235:genetics / Q000821:virology*
D015344:DNA Probes, HPV; D016228:Endothelial Growth Factors; D015513:Oncogene Proteins; D012367:RNA, Viral