In vitro pharmacodynamic characteristics of nystatin including time-kill and postantifungal effect.
Four Candida albicans isolates and six non-albicans Candida isolates were evaluated by time-kill methods to characterize the relationship between nystatin concentrations, the rate and extent of fungicidal activity, and the postantifungal effect (PAFE). Against Candida species, nystatin exhibits concentration-dependent fungicidal activity and a pronounced PAFE.
Gunderson
S M
SM
College of Pharmacy, College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.
Hoffman
H
H
Ernst
E J
EJ
Pfaller
M A
MA
Klepser
M E
ME
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000382:microbiology; D015169:Colony Count, Microbial; D008826:Microbial Sensitivity Tests; D009761:Nystatin / Q000494:pharmacology*
D000935:Antifungal Agents; D009761:Nystatin