title: Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase.
abstract: We examined whether transmyocardial revascularization (TMR) relieves myocardial ischemia by increasing regional perfusion via the transmural channels in acute canine experiments. Regional blood flow during transient coronary ligation (2 min) was compared before and 30 min after TMR, and at the third transient ischemia the mid-left ventricle (LV) was cut and immediately frozen along the short axis for the analysis of NADH fluorescence in the regions around the TMR channels. In low-resolution analysis (2-4 g tissue or 2-3 cm(2) area), regional perfusion was not significantly altered after TMR, and NADH fluorescence was observed throughout the ischemic region without significant spatial variation. High-resolution analysis (2.8 mg, 1 mm x 1 mm) revealed that the flow after TMR was lower, and NADH fluorescence was higher in the regions close to the channels (1-2 mm) than in the regions 3-4 mm away from them. Creating TMR channels did not improve the regional perfusion and rather aggravated the local ischemia in the vicinity of the channels in the immediate phase.
authors.affiliation: Department of Physiology, Tokai University School of Medicine, Isehara 259-1193, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hattan
authors.forename: K
authors.initials: K
authors.lastname: Ban
authors.forename: E
authors.initials: E
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Sekka
authors.forename: Y
authors.initials: Y
authors.lastname: Sugio
authors.forename: M U
authors.initials: MU
authors.lastname: Mohammed
authors.forename: E
authors.initials: E
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Shinozai
authors.forename: Y
authors.initials: Y
authors.lastname: Onishi
authors.forename: H
authors.initials: H
authors.lastname: Suma
authors.forename: S
authors.initials: S
authors.lastname: Handa
authors.forename: S
authors.initials: S
authors.lastname: Kawada
authors.forename: S
authors.initials: S
authors.lastname: Hori
authors.forename: A
authors.initials: A
authors.lastname: Iida
authors.forename: H
authors.initials: H
authors.lastname: Nakazawa
authors.forename: H
authors.initials: H
authors.lastname: Mori
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001783:Blood Flow Velocity; D003326:Coronary Circulation; D004195:Disease Models, Animal; D004285:Dogs; D053685:Laser Therapy / Q000009:adverse effects*; D008863:Microspheres; D017202:Myocardial Ischemia / Q000378:metabolism / Q000601:surgery*; D009204:Myocardial Revascularization / Q000009:adverse effects* / Q000379:methods; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D009243:NAD / Q000032:analysis / Q000378:metabolism; D011184:Postoperative Period; D012044:Regression Analysis; D013052:Spectrometry, X-Ray Emission
chemical_list: D009243:NAD