title: Monoselenolipoic acid may be an outstanding pharmaceutical antioxidant with direct thioredoxin-like activity.
abstract: Owing to the low pKa of its selenohydryl group, reduced monoselenolipoic acid (MSL) can be expected to be a very versatile antioxidant with direct thioredoxin-like activity. Since MSL supports the growth of lipoate-dependent bacteria, it can be anticipated that MSL will be susceptible to reversible reduction by one or more of the enzymes that reduces lipoic acid - thus greatly potentiating MSL's utility as an antioxidant. If it is not metabolized to release toxic free selenide, MSL may have interesting pharmaceutical potential.
authors.affiliation: Pantox Laboratories, San Diego, California 92109, USA.
authors.forename: M F
authors.initials: MF
authors.lastname: McCarty
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D012643:Selenium; D008063:Thioctic Acid / Q000737:chemistry*; D013879:Thioredoxins / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D009942:Organometallic Compounds; D013879:Thioredoxins; D008063:Thioctic Acid; D012643:Selenium