Alkaloid synthesis using chiral delta-amino beta-ketoesters: a stereoselective synthesis of (-)-lasubine II.
[reaction: see text]A highly stereoselective asymmetric synthesis of the quinolizidinealkaloid (-)-lasubine II from a delta-amino beta-hydroxy ketone, a new polyfunctionalized chiral building block, is described.
Davis
F A
FA
Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA. fdavis@astro.ocis.temple.edu
Chao
B
B
D000470:Alkaloids / Q000138:chemical synthesis*; D000596:Amino Acids / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D011807:Quinolizines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000470:Alkaloids; D000596:Amino Acids; D007202:Indicators and Reagents; D011807:Quinolizines; C414385:lasubin I