Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat.
Electrophysiological and anatomic studies suggest that the amygdala regulates gastrointestinal motility and gastric acid secretion via projections to the dorsal vagal complex. The topography of these projections is poorly understood. Here, these projections were investigated by injecting anterograde tracer, Phaseolus vulgaris-leucoagglutinin, into the different divisions of the central nucleus of the amygdala in 13 rats. The distribution of immunohistochemically labeled terminals in the different portions of the dorsal vagal complex was analyzed. We found that (1) the dorsal aspect of the medial division of the central nucleus provided moderate projections to the dorsal vagal complex; (2) the heaviest projections terminated in the parvicellular and medial divisions of the nucleus of the solitary tract. These data suggest that via topographically organized projections, the amygdala can modulate the vago-vagal gastrointestinal reflexes in emotional and stressful situations.
Liubashina
O
O
Laboratory of Cortico-Visceral Physiology, Pavlov Institute of Physiology, nab. Makarova 6, 199034, St. Petersburg, Russia.
Jolkkonen
E
E
Pitkänen
A
A
D000679:Amygdala / Q000033:anatomy & histology*; D000818:Animals; D004064:Digestive System / Q000033:anatomy & histology* / Q000294:innervation*; D004594:Electrophysiology; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology; D010835:Phytohemagglutinins / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014630:Vagus Nerve / Q000502:physiology
D010835:Phytohemagglutinins; C100156:leukoagglutinins, plants