3D QSAR studies on new piperazine derivatives with antihistamine and antibradykinin effects.
Three dimensional QSAR studies for antihistamine and antibradykinin effects of new piper azine derivatives were conducted using the comparative molecular field analysis. Electro static and steric factors, but not hydrophobic factor, of the synthesized compounds were correlated with the antagonistic effect.
Choo
H Y
HY
School of Pharmacy, Ewha Womans University, Seoul, Korea. hypark@mm.ewha.ac.kr
Chung
B J
BJ
D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors*; D006633:Histamine Antagonists / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D010879:Piperazines / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship; D013329:Structure-Activity Relationship
D006633:Histamine Antagonists; D010879:Piperazines; D001920:Bradykinin