[Effectiveness of the surgical treatment of patients with pulmonary tuberculosis and multidrug resistance of its causative agent].
In 1996-1998, the Central Institute of Tuberculosis, Russian Academy of Medical Sciences performed more than 600 operations. Of them 90 (15%) patients isolated mycobacteria. The drug resistance of M. tuberculosis was found in 69 (76.7%) patients. In 60.9% of cases, the resistance of M. tuberculosis to isoniazid and rifampicin was concurrently accompanied by that to one (21.4%), two (61.0%), and even 3 (14.8%) tuberculostatics. Removal of the lung or its remnants in the extrapleural layer was most common (67.7%); thoracic cavernomyoplastic operations were made in 17.4% of cases, and partial resections accounted for only 13%. Postoperative complications were more frequently encountered in patients with drug-resistant tuberculosis than in controls (6.7%). Among them, tuberculosis progression and empyema were prevalent (13%). The clinical efficiency and duration of surgical treatment were directly related to the rates of progression and to the magnitude of drug-resistance of Mycobacteria.
Shaĭkhaev
A Ia
AIa
Naumov
V N
VN
D000904:Antibiotics, Antitubercular / Q000494:pharmacology / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D004352:Drug Resistance, Microbial; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology / Q000627:therapeutic use; D007612:Kanamycin / Q000494:pharmacology / Q000627:therapeutic use; D007613:Kanamycin Resistance; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use; D013307:Streptomycin / Q000494:pharmacology / Q000627:therapeutic use; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000601:surgery*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000601:surgery*
D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D007612:Kanamycin; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin