title: Vaccine delivery: lipid-based delivery systems.
abstract: Needle-free delivery of vaccines should not only increase compliance, but should also prove to be a safer and less traumatic method of vaccine delivery. One of the potential ways to achieve needle-free delivery is with the use of lipid-based delivery systems. To demonstrate the utility of these systems, we have shown them to be effective with proteins produced by recombinant DNA technology, plasmid-based vaccines, as well as conventional vaccines. Furthermore, these lipid-based delivery systems were shown to be effective in inducing mucosal immunity if delivered to mucosal surfaces or systemic immunity if different transdermally. These approaches have the potential to revolutionize vaccine delivery in humans and animals.
authors.affiliation: Veterinary Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, S7N 5E3, Saskatoon, Canada. baca@sask.usask.ca
authors.forename: M E
authors.initials: ME
authors.lastname: Baca-Estrada
authors.forename: M
authors.initials: M
authors.lastname: Foldvari
authors.forename: S L
authors.initials: SL
authors.lastname: Babiuk
authors.forename: L A
authors.initials: LA
authors.lastname: Babiuk
mesh_terms: D006801:Humans; D008055:Lipids / Q000008:administration & dosage*; D014612:Vaccines / Q000008:administration & dosage*
chemical_list: D008055:Lipids; D014612:Vaccines