Organic transformations catalyzed by engineered yeast cells and related systems.
Asymmetric ketone reductions remain the most popular application of baker's yeast (Saccharomyces cerevisiae) in organic synthesis and data from the genome sequencing project is beginning to have an impact on improving the stereoselectivities of these reactions, augmenting traditional approaches based on selective inhibition. In addition, the catalytic repertoire of yeast has been expanded to include chiral ketone oxidations by overexpression of a bacterial Baeyer-Villiger monooxygenase.
Stewart
J D
JD
Department of Chemistry, University of Florida, Gainesville 32611, USA. jds2@chem.ufl.edu
D000429:Alcohol Oxidoreductases / Q000235:genetics / Q000378:metabolism; D001709:Biotechnology / Q000379:methods*; D002384:Catalysis; D005818:Genetic Engineering / Q000379:methods; D007659:Ketones / Q000737:chemistry / Q000378:metabolism; D015003:Yeasts / Q000235:genetics* / Q000378:metabolism*
D007659:Ketones; D000429:Alcohol Oxidoreductases