T-ALL with monoclonal gammopathy and hairy cell features.
The presented case is a boy with T-cell acute lymphoblastic leukemia (ALL) with hairy cell (HC) features and monoclonal gammopathy. The disease process had an acute onset and followed a rapid, progressive course. The patient had minimal splenomegaly and bicytopenia, but the bone marrow displayed increased numbers of reticulin fibers. The blasts were positive for tartrate-resistant acid phosphatase (TRAP) and CD11c. Molecular analysis revealed rearrangement of immunoglobulin heavy chain genes and a rearranged T-cell receptor (TcRbeta) beta gene. The patient responded to conventional ALL therapy. Acute T-cell ALL with HC features in childhood has not been reported previously, either alone or in association with monoclonal gammopathy. We propose "T-ALL with hairy cell features" to describe this case.
Yetgin
S
S
Unit of Pediatric Hematology, Ihsan Doğramaci Children's Hospital, Hacettepe University, Ankara, Türkiye.
Olcay
L
L
Yel
L
L
Tuncer
M
M
Tezcan
I
I
Erdemli
E
E
Oner
A F
AF
Behm
F G
FG
D000293:Adolescent; D000954:Antigens, Surface / Q000235:genetics; D015139:Blotting, Southern; D001854:Bone Marrow Cells / Q000276:immunology / Q000473:pathology / Q000648:ultrastructure; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D010265:Paraproteinemias / Q000150:complications* / Q000235:genetics / Q000473:pathology*
D000954:Antigens, Surface