title: [Midodrine (Gutron) treatment of permanent arterial hypotension in a chronic hemodialysis patient].
abstract: Chronic hypotension, although unfrequent in uremic patients on hemodialysis, accentuates the deterioration of patients physical state and thus, their general well-being. These patients often experience acute intradialytic symptoms and respond very poorly to conventional therapies. Well tolerated, midodrine is a suitable and effective choice as it raises blood pressure significantly through its effect on peripheral alpha-adrenergic receptors. The authors report observing the use of midodrine by a dialysis patient during the longest time period published to date, documented by a pharmacokinetic study, and that confirms the excellent results and proves long term tolerance for that drug.
authors.affiliation: Service de néphrologie-hémodialyse, Centre hospitalier de Troyes.
authors.forename: R
authors.initials: R
authors.lastname: Montagnac
authors.forename: P
authors.initials: P
authors.lastname: Clavel
authors.forename: B
authors.initials: B
authors.lastname: Delhotal-Landes
authors.forename: B
authors.initials: B
authors.lastname: Flouvat
authors.forename: S
authors.initials: S
authors.lastname: Poulain
authors.forename: F
authors.initials: F
authors.lastname: Schillinger
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002908:Chronic Disease; D006333:Heart Failure / Q000150:complications; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D007022:Hypotension / Q000188:drug therapy* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D008879:Midodrine / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006435:Renal Dialysis
chemical_list: D000316:Adrenergic alpha-Agonists; D008879:Midodrine