Chemistry and clinical biology of the bryostatins.
Bryostatins are a class of antineoplastic compounds isolated from the bryozoans Bugula neritina. A wide range of scientific research is currently underway, studying different aspects of the bryostatins. In this review we try to summarize the latest findings, including all the topics involved, from marine biology to medicinal chemistry.
Mutter
R
R
Department of Chemistry, University of Warwick, Coventry, UK. mspbv@cvs.warwick.ac.uk
Wills
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D054713:Bryostatins; D002013:Bryozoa / Q000737:chemistry* / Q000378:metabolism; D002986:Clinical Trials as Topic; D004354:Drug Screening Assays, Antitumor; D004789:Enzyme Activation; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D018942:Macrolides; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D011493:Protein Kinase C / Q000737:chemistry / Q000378:metabolism*
D000970:Antineoplastic Agents; D054713:Bryostatins; D007783:Lactones; D018942:Macrolides; C046785:bryostatin 1; D011493:Protein Kinase C