Inhibition of T-lymphocyte proliferation by cucurbitacins from Picrorhiza scrophulariaeflora.
Two cucurbitacin aglycons were isolated from the dried rhizomes of Picrorhiza scrophulariaeflora and were identified as 25-acetoxy-2,3, 16,20-tetrahydroxy-9-methyl-19-norlanosta-5,23-dien-22-one (picracin, 1) and 2,3,16,20,25-pentahydroxy-9-methyl-19-norlanosta-5, 23-dien-22-one (deacetylpicracin, 2). Both compounds inhibit mitogen-induced T-lymphocyte proliferation at an IC(50) value of 1 microM.
Smit
H F
HF
Section Medicinal Chemistry, Department of Pharmacy, Universiteit Utrecht, P.O. Box 80082, 3508 TB Utrecht, The Netherlands. H.F.Smit@pharm.uu.nl
van den Berg
A J
AJ
Kroes
B H
BH
Beukelman
C J
CJ
Quarles van Ufford
H C
HC
van Dijk
H
H
Labadie
R P
RP
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D019684:Magnoliopsida; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014315:Triterpenes