Cell proliferation in normal and malignant transformed cells: thermodynamic model of signal transduction.
We present a new thermodynamic model for the mechanism of activation and regulation of cell proliferation in the G1 stage. In this model, the interactions between growth factors and transmembrane proteins play a crucial role in cell growth control for a normal tissue-culture system. We calculate a phase diagram of normal and malignant transformed states of a cell signal transduction system. We propose thermodynamic reasons why cancer cells can continually grow without activation by the growth factors.
Kuznetsov
D V
DV
Institute of Biochemical Physics, Russian Academy of Sciences, Kosygin Street 4, Moscow 117977, Russia.
Blokhin
A V
AV
D055592:Biophysical Phenomena; D001703:Biophysics; D002455:Cell Division / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D016193:G1 Phase; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*; D013816:Thermodynamics
D006133:Growth Substances; D008565:Membrane Proteins