[The effect of netilmicin, amikacin, ceftazidime and cefotaxime on the adhesive properties of microorganisms isolated from newborn infants].
The effect of netilmycin, amikacin, ceftazidime and cefotaxime on adhesion of Lactobacillus spp. (14 strains), Escherichia coli (21 strains), Klebsiella pneumonia (15 strains), Enterococcus sp. (18 strains), Candida albicans (15 strains) was investigated. The strains were isolated from respiratory tract and feces of the newborns. Antibiotics were used in the following subtherapeutic and therapeutic concentrations: netilmycin--1.2 and 12.0 micrograms/ml, amikacin--1.8 and 18 micrograms/ml, ceftazidime--7.5 and 75 micrograms/ml, cefotaxime--6.5 and 75 micrograms/ml. Adhesion of C. albicans was investigated with buccal epithelium cells, adhesion of other microorganisms--on formalinized human erythrocytes (1(0)Rh(+)). It was shown that antibiotics in subtherapeutic and therapeutic concentrations inhibited adhesion of the most strains. Cefalosporins demonstrated maximum inhibitory activity. The number of the strains inhibited by cefalosporins and by aminoglycosides enhanced along with antibiotics concentrations enhancement from subtherapeutic to therapeutic concentrations.
Kushnareva
M V
MV
Moscow Research Institute of Pediatrics and Pediatric Surgery, Ministry of Health of Russian Federation.
D000583:Amikacin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity; D001422:Bacterial Adhesion / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity; D002439:Cefotaxime / Q000494:pharmacology*; D002442:Ceftazidime / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000382:microbiology; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D007231:Infant, Newborn; D009428:Netilmicin / Q000494:pharmacology*; D012137:Respiratory System / Q000382:microbiology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D009428:Netilmicin; D000583:Amikacin; D002442:Ceftazidime; D002439:Cefotaxime