Steroidal saponins from Dracaena surculosa.
A phytochemical investigation of the whole plant of Dracaena surculosa resulted in the isolation of nine steroidal saponins, including three new bisdesmosidic spirostanol saponins, named surculosides A (1), B (2), and C (3), and a new bisdesmosidic furostanol saponin (4), which are based on (25S)-spirost-5-ene-1beta, 3beta-diol [(25S)-ruscogenin] as the aglycon. The structures of 1-4 were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and the results of hydrolytic cleavage. The isolated saponins were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells.
Yokosuka
A
A
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Mimaki
Y
Y
Sashida
Y
Y
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D019684:Magnoliopsida; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D013057:Spectrum Analysis; D013256:Steroids / Q000737:chemistry*
D012503:Saponins; D013256:Steroids