Vascular-specific growth factors and blood vessel formation.
A recent explosion in newly discovered vascular growth factors has coincided with exploitation of powerful new genetic approaches for studying vascular development. An emerging rule is that all of these factors must be used in perfect harmony to form functional vessels. These new findings also demand re-evaluation of therapeutic efforts aimed at regulating blood vessel growth in ischaemia, cancer and other pathological settings.
Yancopoulos
G D
GD
Regeneron Pharmacueticals, Inc., Tarrytown, New York 10591, USA.
Davis
S
S
Gale
N W
NW
Rudge
J S
JS
Wiegand
S J
SJ
Holash
J
J
D042702:Angiopoietin-2; D000818:Animals; D016228:Endothelial Growth Factors / Q000235:genetics / Q000502:physiology*; D036388:Ephrin-B2; D008222:Lymphokines / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic / Q000187:drug effects; D011506:Proteins / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology; D042764:Receptors, TIE; D040262:Receptors, Vascular Endothelial Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D042702:Angiopoietin-2; D016228:Endothelial Growth Factors; D036388:Ephrin-B2; D008222:Lymphokines; D008565:Membrane Proteins; D011506:Proteins; D017978:Receptors, Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D020794:Receptor Protein-Tyrosine Kinases; D042764:Receptors, TIE; D040262:Receptors, Vascular Endothelial Growth Factor