Actin cytoskeleton: thinking globally, actin' locally.
A class of proteins dubbed pipmodulins bind to and sequester the phospholipid PIP2 in the plasma membrane. Local release of PIP2 controls actin dynamics in specific subcellular regions and plays a critical role in regulating actin-based cell motility and morphogenesis.
Lanier
L M
LM
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA. lmlanier@mit.edu
Gertler
F B
FB
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D019922:GAP-43 Protein / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D021962:Membrane Microdomains; D008565:Membrane Proteins; D000076250:Myristoylated Alanine-Rich C Kinase Substrate; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
D000199:Actins; D019922:GAP-43 Protein; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D019269:Phosphatidylinositol 4,5-Diphosphate; D011506:Proteins; D000076250:Myristoylated Alanine-Rich C Kinase Substrate; D011493:Protein Kinase C