Comparative analysis of neuroprotective activity of new chemical agent Vp and piracetam.
The effect of new agent Vp (9-butylamine-3,3-dimethyl-3,4-dihydroacridine-1(2H) hydrochloride) on lifetime of isolated mechanoreceptive crayfish neurons was evaluated by the duration of its impulse activity. Vp significantly and dose-dependently prolonged the lifetime of both spontaneously degrading neurons and neurons degrading under conditions of inhibition of various stages of the energy metabolism: glycolysis and oxidative phosphorylation. The effect of Vp in a concentration of 10(-7) M surpassed that of amiridine. Piracetam also prolonged the lifetime of spontaneously degrading neurons, but only in very high concentration (10(-2) M). It is concluded that Vp possesses a neuroprotective activity.
Burov
Y V
YV
Research Center for Safety of Bioactive Compounds, Staraya Kupavna, Moscow Region.
Uzdenskii
A B
AB
Robakidze
T N
TN
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D003400:Astacoidea; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*
C118471:9-butylamino-3,3-dimethyl-3,4-dihydroacridinone; D000166:Acridines; D018696:Neuroprotective Agents; D010889:Piracetam