Differential sensitivities of Chlamydia trachomatis strains to inhibitory effects of gamma interferon.
Gamma interferon (IFN-gamma) is an important cytokine in host defense against chlamydial infection. An in vitro cell culture system was used to show that IFN-gamma inhibition of chlamydial growth, as determined by diminished recovery of infectious elementary bodies, differed markedly among chlamydial strains. These differences in sensitivity among chlamydial strains to IFN-gamma-mediated inhibition may profoundly influence the clinical outcome of infection.
Morrison
R P
RP
Department of Microbiology, Montana State University, Bozeman, Montana 59717, USA. morrison@montana.edu
D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000254:growth & development; D002691:Chlamydophila psittaci / Q000187:drug effects* / Q000254:growth & development; D006367:HeLa Cells; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*
D007371:Interferon-gamma