[(1)N,(12)N]Bis(Ethyl)-cis-6,7-dehydrospermine: a new drug for treatment and prevention of Cryptosporidium parvum infection of mice deficient in T-cell receptor alpha.
Cryptosporidium parvum infection of T-cell receptor alpha (TCR-alpha)-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) prevented C. parvum infection in suckling TCR-alpha-deficient mice and cleared an existing infection in older mice. Treatment with putrescine, while capable of preventing infection, did not clear C. parvum from previously infected mice. These findings provide further evidence that polyamine metabolic pathways are targets for new anticryptosporidial chemotherapeutic agents.
Waters
W R
WR
Bacterial Diseases of Livestock Unit, National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 50010, USA. rwaters@nadc.ars.usda.gov
Frydman
B
B
Marton
L J
LJ
Valasinas
A
A
Reddy
V K
VK
Harp
J A
JA
Wannemuehler
M J
MJ
Yarlett
N
N
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002432:Cecum / Q000469:parasitology / Q000473:pathology; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D016785:Cryptosporidium parvum; D019673:Genes, T-Cell Receptor alpha / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011700:Putrescine / Q000494:pharmacology; D013096:Spermine / Q000031:analogs & derivatives* / Q000627:therapeutic use
C415967:(N(1),N(12))bis(ethyl)-6,7-dehydrospermine; D000981:Antiprotozoal Agents; D013096:Spermine; D011700:Putrescine