SB-253514 and analogues: novel inhibitors of lipoprotein associated phospholipase A2 produced by Pseudomonas fluorescens DSM 11579. II. Physico-chemical properties and structure elucidation.
A series of novel inhibitors of lipoprotein associated phospholipase A2 were isolated from the culture broths of Pseudomonas fluorescens strain DSM11579. The inhibitors fall into two structurally isomeric classes each of which comprise compounds incorporating glycosylated hydrocarbon chains. The structure elucidation for the major member of each structural class is reported. The crystal structure of a non-glycosylated analogue of the 5,5-series, produced through biotransformation, is also reported.
Busby
D J
DJ
SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.
Copley
R C
RC
Hueso
J A
JA
Readshaw
S A
SA
Rivera
A
A
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011551:Pseudomonas fluorescens / Q000378:metabolism; D011714:Pyrans / Q000737:chemistry
D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D011714:Pyrans; C414127:SB 253514; C414143:SB 311009; C414142:SB 315021; D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase