Eradication of non-typhoid salmonellae in acute enteritis after therapy with ofloxacin for 5 or 10 days.
Eradication of non-typhoid salmonellae was evaluated in a randomized, double-blinded study of 49 patients with acute enteritis after therapy with ofloxacin 400 mg once daily for 5 or 10 days. Early eradication of salmonellae was found in 57% of patients in the 5 day therapy group and in 74% of patients in the 10 day therapy group. This difference was larger among severely ill patients. Together with our previous study of ofloxacin therapy for 3 days or placebo, this shows that early eradication of non-typhoid salmonellae increases with duration of ofloxacin therapy without an increase in persistence of salmonellae in stools or development of resistant strains.
Voltersvik
P
P
Department of Infectious Diseases Prevention, City of Bergen, Norway. pal.voltersvik@vir.uib.no
Halstensen
A
A
Langeland
N
N
Digranes
A
A
Peterson
L E
LE
Rolstad
T
T
Solberg
C O
CO
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D004751:Enteritis / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use*; D012475:Salmonella / Q000302:isolation & purification; D012480:Salmonella Infections / Q000188:drug therapy* / Q000382:microbiology; D012477:Salmonella enteritidis / Q000302:isolation & purification; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D015242:Ofloxacin