title: [Dental changes in patients treated with calcium antagonists].
abstract: For a period of 7 years the dental status of 160 patients has been investigated and followed. These patients have been treated with calcium channel blockers and selected in age between 22 and 50 years. Their diagnoses are: m. hypertonicus I-II stage--106, WPW-syndrome--10, stenocardia--18, atrial extrasystolia--26. Duration of treatment--from 1 to 7 years (corinfar, nifedipin, adalat--tabl. 40 mg, taken peroral or chewed, respectively suck; isoptin, verapamil--tabl. 40 mg, diltiazem--tabl. 30 mg, taken peroral. A control group of 60 clinically well people at age from 20 to 48 years was investigated. Under continuous treatment with calcium antagonist (> 1 year) the examined patients are found to have considerable decalcination of the dental enamel and caries more frequent (87.5%) compared to the group of clinically healthy people (65%), also increased number of caries in the same patient in comparison to his dental status before starting the therapy in 108 of 160 (67.5%). The differences in the results are statistically significant (p < 0.001). The number of the discovered caries in patients treated with calcium channel blockers and in the studied groups is also large (4 to 2 on average, i.e. two times more). The results allow to recommend a continuous stomatological control for patients treated with calcium antagonists.
authors.forename: S
authors.initials: S
authors.lastname: Ivanova
authors.forename: A
authors.initials: A
authors.lastname: Kiselova-Ianeva
authors.forename: L
authors.initials: L
authors.lastname: Dimitrov
authors.forename: N
authors.initials: N
authors.lastname: Stanchev
mesh_terms: D000328:Adult; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy; D003731:Dental Caries / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014070:Tooth / Q000187:drug effects*
chemical_list: D002121:Calcium Channel Blockers