The hydroxyproline content of amnion and prelabour rupture of the membranes.
OBJECTIVE
To determine whether prelabour rupture of the membranes is caused by a generalised reduction in amniotic collagen.


METHODS
Leeds General Infirmary, UK.


METHODS
The hydroxyproline content of amnion from 55 women with prelabour rupture of the membranes was compared with that from 50 women whose membranes ruptured during labour and 28 women who were delivered by elective caesarean section.


RESULTS
No association was found between hydroxyproline content and the timing of membrane rupture. Hydroxyproline content was inversely correlated with gestation. The hydroxyproline content per cm(2) amnion was significantly increased in cases which had laboured. There was a strong correlation between the mechanical properties and the hydroxyproline content of amnion.


CONCLUSIONS
PROM is not associated with a generalised reduction in the hydroxyproline content of amnion.
MacDermott
R I
RI
Department of Obstetrics and Gynaecology, Leeds General Infirmary, LS1 3EX, Leeds, UK.
Landon
C R
CR
D000650:Amnion / Q000737:chemistry* / Q000502:physiology; D001696:Biomechanical Phenomena; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis*; D008297:Male; D011247:Pregnancy; D012727:Sex Characteristics; D012907:Smoking
D006909:Hydroxyproline