title: Correlation between Propionibacterium acnes biotypes, lipase activity and rash degree in acne patients.
abstract: We examined the possible correlation between biotypes of Propionibacterium acnes, lipase activity, and rash degree in acne patients. Among 5 P. acnes biotypes, P. acnes biotype 3 (B3) was the most common, followed by P. acnes biotypes 1, 2 and 4; P. acnes biotype 5 was not found. P. acnes B3 was isolated from more severe skin rashes than those of the other biotypes. Production of propionic acid (PA) and butyric acid (BA) by P. acnes B3 was higher than those by the other P. acnes biotypes. As the rash degree in acne patients was more severe, the production of PA and BA elevated. Although only a few P. acnes strains were examined in the present study, P. acnes B3 had the highest lipase activity and might have the greatest influence on skin rash in acne patients.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Higaki
authors.forename: T
authors.initials: T
authors.lastname: Kitagawa
authors.forename: M
authors.initials: M
authors.lastname: Kagoura
authors.forename: M
authors.initials: M
authors.lastname: Morohashi
authors.forename: T
authors.initials: T
authors.lastname: Yamagishi
mesh_terms: D000152:Acne Vulgaris / Q000382:microbiology* / Q000473:pathology; D005148:Facial Dermatoses / Q000382:microbiology* / Q000473:pathology; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008049:Lipase / Q000378:metabolism*; D011425:Propionibacterium acnes / Q000145:classification* / Q000201:enzymology* / Q000302:isolation & purification; D012720:Severity of Illness Index
chemical_list: D008049:Lipase