title: Avidity regulation of integrins: the driving force in leukocyte adhesion.
abstract: The activity of integrins on leukocytes is tightly controlled, and their adhesion capacity shifts rapidly when cells emigrate from the blood to the tissues. The leukocyte-specific beta2 integrin LFA-1 (alphaLbeta2) is the most important integrin expressed by leukocytes that regulate lymphocyte migration and the initiation of an immune response through binding to ICAM-1,-2 or-3. The binding activity of LFA-1 is rapidly altered by intracellular stimuli that activate LFA-1. Although alterations in the affinity of LFA-1, which leads to enhanced ICAM-1 binding, have been proposed, evidence is emerging that dynamic reorganisation of LFA-1 into microclusters is the major mechanism that regulates its binding capacity.
authors.affiliation: Department of Tumor Immunology, University Medical Center Nijmegen, St Radboud, P. Van Leydenlaan 25, 6525 EX, the, Nijmegen, Netherlands. Y.vanKooyk@dent.kun.nl
authors.forename: Y
authors.initials: Y
authors.lastname: van Kooyk
authors.forename: C G
authors.initials: CG
authors.lastname: Figdor
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000378:metabolism*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D016169:Lymphocyte Function-Associated Antigen-1