Risk factors for recurrent urinary tract infection in young women.
To define host factors associated with an increased risk of recurrent urinary tract infection (RUTI), a case-control study was conducted in 2 populations: university women and health maintenance organization enrollees. Case patients were 229 women 18-30 years old with RUTIs; control subjects were 253 randomly selected women with no RUTI history. In a multivariate model, independent risk factors for RUTI included recent 1-month intercourse frequency (odds ratio [OR], 5.8; 95% confidence interval [CI], 3.1-10.6 for 4-8 episodes), 12-month spermicide use (OR, 1.8; 95% CI, 1.1-2.9), and new sex partner during the past year (OR, 1.9; 95% CI, 1.2-3.2). Two newly identified risk factors were age at first urinary tract infection (UTI) </=15 years (OR, 3.9; 95% CI, 1.9-8.0) and UTI history in the mother (OR, 2.3; 95% CI, 1.5-3.7). Blood group and secretor phenotype were not associated with RUTI. In young women, risk factors for sporadic UTI are also risk factors for recurrence. Two predictors suggest that genetic/long-term environmental exposures also predispose to RUTI.
Scholes
D
D
Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA 98101. scholes.d@ghc.org
Hooton
T M
TM
Roberts
P L
PL
Stapleton
A E
AE
Gupta
K
K
Stamm
W E
WE
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D003153:Community Health Services; D003270:Contraceptive Agents; D005006:Ethnicity; D005260:Female; D006279:Health Maintenance Organizations; D006801:Humans; D009035:Mothers; D016017:Odds Ratio; D044469:Racial Groups; D012008:Recurrence; D012307:Risk Factors; D012725:Sexual Behavior; D014495:Universities; D014552:Urinary Tract Infections / Q000453:epidemiology* / Q000503:physiopathology; D014861:Washington / Q000453:epidemiology
D003270:Contraceptive Agents