Biotransformations with Rhizopus arrhizus and Geotrichum candidum for the preparation of (S)-atenolol and (S)-propranolol.
(+/-)-Atenolol/(+/-)-propranolol and their acetates were incubated with the fungus Rhizopus arrhizus and Geotrichum candidum separately for different time intervals to afford (S)-atenolol/(S)-propranolol in good optical yield. The time and pH for this biotransformation was optimised. The present biodegradations using Rhizopus arrhizus and Geotrichum candidum provides a simple and useful method to obtain (S)-atenolol and (S)-propranolol which are active enantiomers of the beta-adrenergic blockers.
Damle
S V
SV
Department of Chemistry, The Institute of Science, Mumbai, India.
Patil
P N
PN
Salunkhe
M M
MM
D000319:Adrenergic beta-Antagonists / Q000737:chemistry* / Q000378:metabolism; D001262:Atenolol / Q000737:chemistry* / Q000378:metabolism; D001673:Biodegradation, Environmental; D001711:Biotransformation; D005848:Geotrichum / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008968:Molecular Conformation; D015394:Molecular Structure; D011433:Propranolol / Q000737:chemistry* / Q000378:metabolism; D012233:Rhizopus / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D011433:Propranolol