Fine-needle aspiration cytology of Schiller-Duval bodies of yolk-sac tumor.
The objective of this study was to find the cytological equivalent of Schiller-Duval bodies seen in histology in order to employ the findings as a diagnostic clue for yolk-sac tumor (YST) in aspiration biopsy. A YST, aspirated from the retroperitoneal lymph node of a 29-yr-old Asian man with testicular complex mature teratoma, contained numerous Schiller-Duval bodies on cell block sections. In the corresponding smears, a network of tumor cell-coated, anastomosing, thin-walled, rigid hematopoietic channels with dramatic changes in diameter was observed, in agreement with the diagram based on the reconstruction of 48 serial plastic sections done by Kazancigil et al. (Am J Cancer 1940;40:199-212). In addition, some of the hematopoietic channels folded over several times like a long, narrow balloon pinched at its joints, i.e., "balloon animal"-like. Many segments of the allantoic viteline vascular network, fractured by smearing, exhibited three- or four-way branchings, bulbous protrusions, and cauliflower-like branchings of widely variable diameter.
Yang
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Department of Pathology, New York University School of Medicine, New York, New York 10016, USA.
D000328:Adult; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D018240:Endodermal Sinus Tumor / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009919:Orchiectomy; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery