Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis.
The development of a solution phase synthesis of azatriostin A (2) suitable for the preparation of combinatorial libraries enlisting only liquid-liquid acid/base extractions for the isolation and purification of all intermediates and the final product is disclosed.
Boger
D L
DL
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. boger@scripps.edu
Lee
J K
JK
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D007364:Intercalating Agents / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D011810:Quinoxalines / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D007364:Intercalating Agents; D011810:Quinoxalines; C031945:triostin A