Effect of magnesium sulfate on learning, emotivity and spontaneous motility in rats.
The study was performed on three groups, each including 10 male Wistar rats, weighing 110-130 g: group 1, the control group; group 2, animals treated with magnesium sulfate in a dose of 100 mg/kg body/day i.m.; group 3, animals treated with double dose of magnesium sulfate (200 mg/kg body/day i.m.). All animals were tested for emotivity and spontaneous motility in the open field, as well as for their capacity of acquiring active avoidance conditioned reflexes in the shuttle-box, for 9 days. Magnesium sulfate decreased significantly the learning ability, decreased emotivity scores regardless of the administered dose, and increased significantly spontaneous motility scores only in the double dose treated group.
Lupu
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Pedopsychiatry Department, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca.
Dorofteiu
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D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004644:Emotions / Q000187:drug effects*; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D012018:Reflex / Q000187:drug effects
D008278:Magnesium Sulfate