title: Influence of age and normal plasma fibrinogen levels on flow-mediated dilation in healthy adults.
abstract: This study examined the effects of age-associated increases in fibrinogen on brachial artery flow-mediated dilation in 30 healthy nonsmokers. The findings demonstrate an inverse association between normal plasma fibrinogen levels and vascular function (r = -0.56, p = 0.001), suggesting elevated plasma fibrinogen may decrease the artery's responsiveness to certain vasodilatory signals, such as shear stress.
authors.affiliation: Department of Kinesiology and Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70803, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Allen
authors.forename: J B
authors.initials: JB
authors.lastname: Wilson
authors.forename: R T
authors.initials: RT
authors.lastname: Tulley
authors.forename: M
authors.initials: M
authors.lastname: Lefevre
authors.forename: M A
authors.initials: MA
authors.lastname: Welsch
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004108:Dilatation, Pathologic / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012307:Risk Factors; D018608:Ultrasonography, Doppler
chemical_list: D015415:Biomarkers; D005340:Fibrinogen