title: Topical negative pressure in wound management.
abstract: OBJECTIVE
  To investigate the role of topical negative pressure (TNP) therapy in the management of difficult wounds.
  
  
  METHODS
  Prospective consecutive patient series.
  
  
  METHODS
  30 patients referred to our tertiary plastic and reconstructive surgical service with wounds deemed unsuitable for reconstructive surgery were treated between November 1997 and the end of December 1998. The mean pretreatment duration of the wounds was 418 days (range, 8-1650 days). All wounds were at least Grade III pressure sores.
  
  
  METHODS
  Topical negative pressure therapy (TNP) using the VAC device (KCI Medical, San Antonio, USA). Suction (75-125 mmHg) was continuous for the first 48 hours, then intermittent (2 min on, 5 min off).
  
  
  METHODS
  Achievement of wound healing endpoints: (1) complete healing of the wound; (2) obliteration of the wound cavity to allow surface dressings; or (3) closure of the wound by suture or skin graft.
  
  
  RESULTS
  TNP was successful in 26 out of 30 patients with mean therapy time of 35 days (range, 3-124 days). Healing was more rapid in acute (less than six weeks old) wounds. A reduction in the number of bacterial species and colonies was also observed during therapy.
  
  
  CONCLUSIONS
  TNP can, in some circumstances, promote rapid secondary wound healing. A further randomised trial of TNP versus more traditional wound management modalities is justified.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Prince of Wales Hospital, Sydney, NSW.
authors.forename: A K
authors.initials: AK
authors.lastname: Deva
authors.forename: G H
authors.initials: GH
authors.lastname: Buckland
authors.forename: E
authors.initials: E
authors.lastname: Fisher
authors.forename: S C
authors.initials: SC
authors.lastname: Liew
authors.forename: S
authors.initials: S
authors.lastname: Merten
authors.forename: M
authors.initials: M
authors.lastname: McGlynn
authors.forename: M P
authors.initials: MP
authors.lastname: Gianoutsos
authors.forename: M A
authors.initials: MA
authors.lastname: Baldwin
authors.forename: P G
authors.initials: PG
authors.lastname: Lendvay
mesh_terms: D001458:Bandages; D006801:Humans; D011312:Pressure; D011446:Prospective Studies; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy*