Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity.
The effects of sesamol, a phenolic compound responsible for the high resistance of sesame oil to oxidative deterioration as compared with other vegetable oils, have been investigated after mutagen treatment in various strains of Salmonella typhimurium. Sesamol was shown to exhibit strong antimutagenic effects in the Ames tester strains TA100 and TA102. The TA102 strain has been shown to be highly sensitive to reactive oxygen species. Mutagenicity was induced by the generation of oxygen radicals by tert-butylhydroperoxide (t-BOOH) or hydrogen peroxide (H(2)O(2)); therefore, the antimutagenic property of sesamol was attributed to its antioxidant properties. The superoxide and hydroxyl radical scavenging capabilities have further been elucidated using in vitro test systems. It was further shown to have a desmutagenic effect on t-BOOH-induced mutagenesis in TA102 strain. Sesamol also inhibited the mutagenicity of sodium azide (Na-azide) in TA100 tester strain while it had no effect on nitroquinoline-N-oxide (NQNO)-induced mutagenesis in TA98 strain of Salmonella typhimurium. Since active oxygen species are involved in multiple stage processes of carcinogenicity, this compound may also exhibit anticarcinogenic properties.
Kaur
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IP
University Institute of Pharmaceutical Sciences, Punjab University, 160014, Chandigarh, India. meenashikanwar@mailcity.com
Saini
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D016587:Antimutagenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D052117:Benzodioxoles; D006861:Hydrogen Peroxide / Q000633:toxicity; D009152:Mutagenicity Tests; D010636:Phenols / Q000494:pharmacology*; D017382:Reactive Oxygen Species; D012486:Salmonella typhimurium / Q000187:drug effects; D020122:tert-Butylhydroperoxide / Q000633:toxicity
D016587:Antimutagenic Agents; D000975:Antioxidants; D052117:Benzodioxoles; D010636:Phenols; D017382:Reactive Oxygen Species; C025583:sesamol; D020122:tert-Butylhydroperoxide; D006861:Hydrogen Peroxide