Inferring linkage disequilibrium between a polymorphic marker locus and a trait locus in natural populations.
Three approaches are proposed in this study for detecting or estimating linkage disequilibrium between a polymorphic marker locus and a locus affecting quantitative genetic variation using the sample from random mating populations. It is shown that the disequilibrium over a wide range of circumstances may be detected with a power of 80% by using phenotypic records and marker genotypes of a few hundred individuals. Comparison of ANOVA and regression methods in this article to the transmission disequilibrium test (TDT) shows that, given the genetic variance explained by the trait locus, the power of TDT depends on the trait allele frequency, whereas the power of ANOVA and regression analyses is relatively independent from the allelic frequency. The TDT method is more powerful when the trait allele frequency is low, but much less powerful when it is high. The likelihood analysis provides reliable estimation of the model parameters when the QTL variance is at least 10% of the phenotypic variance and the sample size of a few hundred is used. Potential use of these estimates in mapping the trait locus is also discussed.
Luo
Z W
ZW
Laboratory of Population and Quantitative Genetics, Institute of Genetics, Fudan University, Shanghai 200433, People's Republic of China. zwluo@fudan.edu.cn
Tao
S H
SH
Zeng
Z B
ZB
D000483:Alleles; D000704:Analysis of Variance; D002874:Chromosome Mapping; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D010641:Phenotype; D011110:Polymorphism, Genetic; D019655:Quantitative Trait, Heritable
D005819:Genetic Markers