Inactive systemic lupus erythematosus id associated with a normal stimulated Th(1)/Th(2) cytokine secretory pattern.
OBJECTIVE
To determine the Th(1)/Th(2)balance in systemic lupus erythematosus (SLE) patients with inactive disease.


METHODS
A comprehensive analysis of peak secretion, overall cytokine production and secretory pattern of Th(1)and Th(2)cytokines from stimulated PBMC of 10 SLE patients with inactive disease and 10 age- and sex-matched controls.


RESULTS
No significant differences were found in the peak and total secretion of all cytokines, as well as in the Th(1)and Th(2)secretory patterns and proliferative response between the two groups.


CONCLUSIONS
Th(1)and Th(2) balance in inactive SLE is normal.
Amit
M
M
Department "B" of Internal Medicine, Assaf Harofeh Medical Center, Zerifin, Israel. vazinam@post.tau.ac.il
Mor
A
A
Weissgarten
J
J
Rosenberg
R
R
Ramot
Y
Y
Wysenbeek
A J
AJ
Rapoport
M J
MJ
D000328:Adult; D016022:Case-Control Studies; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D007700:Kinetics; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*; D013997:Time Factors
D016207:Cytokines; D007376:Interleukin-2; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma