Glutamate receptors participate in the nicotine-induced changes of met-enkephalin in striatum.
A single dose of nicotine given to mice induces first a rapid decrease (presumed release/enhanced degradation) and then a rise (presumed synthesis/enhanced accumulation) of met-enkephalin (Met-Enk) in dorsal and ventral striatum observed at 30 and 60 min post-treatment, respectively. These studies investigated whether the nicotine effect on Met-Enk was mediated indirectly, in part, via other neurotransmitters known to be released by nicotine. Based on the ability of selective antagonists of dopamine (Sch 23390, D1; Sulpiride, D2), glutamate (CPP, competitive NMDA; dizocilpine, non-competitive NMDA; NBQX, AMPA) and GABA (bicuculline, GABA(A); Sch 50911, GABA(B)) receptors, to inhibit or enhance the response to nicotine, we conclude that nicotine alters striatal Met-Enk, in part, via glutamate NMDA and AMPA receptors. These findings further support the notion that glutamate might play a role in the pharmacology of nicotine.
Isola
R
R
Department of Psychiatry, The Ohio State University College of Medicine and Public Health, 5034 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA.
Duchemin
A M
AM
Tejwani
G A
GA
Neff
N H
NH
Hadjiconstantinou
M
M
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000378:metabolism*; D008297:Male; D051379:Mice; D009538:Nicotine / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000502:physiology; D011963:Receptors, GABA-A / Q000502:physiology; D018080:Receptors, GABA-B / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology
D018091:Receptors, AMPA; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D004744:Enkephalin, Methionine; D009538:Nicotine