Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus.
A crude extract prepared from Scutellaria barbata D. Don (Lamiaceae) was analyzed in the effort to discover antibacterial compounds against high-level strains of methicillin-resistant Staphylococcus aureus (MRSA). Apigenin and luteolin were isolated from the plant as active constituents against the bacteria. These flavonoid congeners were selectively toxic to S. aureus, including the MRSA and methicillin-sensitive S. aureus strains.
Sato
Y
Y
Laboratory of Microbial Chemistry, Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi 1-78, 770-8505, Tokushima, Japan.
Suzaki
S
S
Nishikawa
T
T
Kihara
M
M
Shibata
H
H
Higuti
T
T
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001483:Base Sequence; D017931:DNA Primers; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D017931:DNA Primers; D005419:Flavonoids