The role of membrane lipids in regulation of integrin functions.
Recent evidence suggests that the biochemical and physical organization of lipid molecules in the plasma membrane can affect integrin-mediated cellular functions. The nature and mechanism of integrin-lipid interactions are unknown, but it is clear that they play specific roles in modulating the properties of integrins and integrin-associated proteins. A better knowledge of integrin functions, especially in the lipid milieu of plasma membranes, is necessary for the understanding of the phenomena that are regulated by integrins.
Pande
G
G
Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India. gpande@ccmb.ap.nic.in
D000818:Animals; D002448:Cell Adhesion; D006801:Humans; D016023:Integrins / Q000502:physiology*; D008563:Membrane Lipids / Q000502:physiology*; D015398:Signal Transduction
D016023:Integrins; D008563:Membrane Lipids