Unilateral bowing of long bones and multiple congenital anomalies in a child born to a mother with gestational diabetes.
We report on a new-born girl with multiple congenital anomalies consisting of major skeletal anomalies restricted to the left side, cleft palate, ventricular and atrial septal defect, retromicrognathia, short neck, dysplastic low-set ears and large birth weight. The left-side bony anomalies include shortening and bowing of the femur and tibia, hypoplasia of the fibula, hip dislocation, clubfoot and mild shortening of the long tubular bones in the left arm with elbow dislocation. The pregnancy was complicated by insulin-dependent gestational diabetes mellitus in the mother. The radiographic features were not consistent with the diagnosis of campomelic dysplasia, kyphomelic dysplasia or other skeletal dysplasias characterized by bowing and shortening of the long bones. To our knowledge, the multiple congenital anomalies, including major skeletal malformations, present in our case have never been simultaneously reported until now. A maternal diabetes syndrome in this infant is probable. The occurrence of major congenital malformations in offspring of women with gestational diabetes is reviewed and discussed. We provide evidence that gestational diabetes mellitus could be teratogenic. We recommend a careful diabetic control in every woman with a history of gestational diabetes.
Courtens
W
W
Department of Medical Genetics, Brugmann University Hospital, Brussels, Belgium. wcourten@ulb.ac.be
De laet
C
C
Ziereisen
F
F
Vamos
E
E
Mortier
G
G
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000209:etiology*; D000328:Adult; D001133:Bones of Upper Extremity / Q000002:abnormalities* / Q000000981:diagnostic imaging; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D016640:Diabetes, Gestational / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007867:Leg Bones / Q000002:abnormalities* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009139:Musculoskeletal Abnormalities / Q000000981:diagnostic imaging / Q000209:etiology; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000150:complications*; D011859:Radiography