Alkaloids from Delphinium staphisagria.
Three new diterpenoid alkaloids, isoazitine (1), 19-oxodihydroatisine (2), and 22-O-acetyl-19-oxodihydroatisine (3), and eight known alkaloids-azitine (4), dihydroatisine (5), delphinine, neoline, bullatine C (14-acetylneoline), chasmanine, 14-acetylchasmanine, and the quaternary base atisinium chloride (7)-were isolated from the aerial parts of Delphinium staphisagria. Structures of the new alkaloids were established mainly by 1D and 2D NMR spectroscopy, including (1)H COSY, HMQC, HMBC, and ROESY. The (1)H and (13)C NMR data for alkaloids 4 and 5 are also reported.
Díaz
J G
JG
Instituto de Bio-Orgánica A. González, CSIC, Universidad de La Laguna, Ctra a la Esperanza 2, 38206, La Laguna-Tenerife, Spain. jglezd@ull.ed
Ruiz
J G
JG
de La Fuente
G
G
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D002853:Chromatography, Liquid; D002855:Chromatography, Thin Layer; D004224:Diterpenes; D008401:Gas Chromatography-Mass Spectrometry; D009018:Morocco; D009904:Optical Rotation; D010947:Plants, Toxic / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
C414610:19-oxodihydroatisine; C414611:22-O-acetyl-19-oxodihydroatisine; D000470:Alkaloids; D004224:Diterpenes; C414609:isoazitine