Solid-phase synthesis of acridine-based threading intercalator peptides.
The preparation of a novel acridine-based amino acid is reported. This N-Alloc-protected monomer can be coupled and deprotected under solid-phase peptide synthesis procedures to create acridine peptide conjugates as potential threading intercalators. A peptide containing this novel amino acid undergoes spectral changes in the presence of duplex DNA and RNA consistent with intercalative binding.
Carlson
C B
CB
Department of Chemistry, University of Utah, Salt Lake City 81112, USA.
Beal
P A
PA
D000166:Acridines / Q000138:chemical synthesis*; D004247:DNA / Q000378:metabolism; D007364:Intercalating Agents / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis*
D000166:Acridines; D007364:Intercalating Agents; D010455:Peptides; D004247:DNA