title: Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells.
abstract: The MeOH extract of Epimedium sagittatum was found to show neurite outgrowth activity on cultured PC12h cells. Bioassay-guided fractionation of the MeOH extract yielded six prenylated flavonol glycosides, ikarisoside A (1), icarisid II (2), epimedoside A (3), icariin (4), epimedin B (5), and epimedokoreanoside-I (6) as the active ingredients.
authors.forename: M
authors.initials: M
authors.lastname: Kuroda
authors.forename: Y
authors.initials: Y
authors.lastname: Mimaki
authors.forename: Y
authors.initials: Y
authors.lastname: Sashida
authors.forename: E
authors.initials: E
authors.lastname: Umegaki
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Chiba
authors.forename: T
authors.initials: T
authors.lastname: Mohri
authors.forename: M
authors.initials: M
authors.lastname: Kitahara
authors.forename: A
authors.initials: A
authors.lastname: Yasuda
authors.forename: N
authors.initials: N
authors.lastname: Naoi
authors.forename: Z W
authors.initials: ZW
authors.lastname: Xu
authors.forename: M R
authors.initials: MR
authors.lastname: Li
mesh_terms: D000818:Animals; D005419:Flavonoids / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
chemical_list: D005419:Flavonoids; D006027:Glycosides