title: Repeated administration of low dose ketamine for the treatment of monoarthritic pain in the rat.
abstract: The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute inflammatory pain in a complete Freund's adjuvant-induced monoarthritic pain model in rats. The results show: (1) sc injection of ketamine at a dose of 2 mg x kg(-1) or 10 mg x kg(-1) produced significant analgesia (P<0.01) in arthritic rats starting from the 2nd week and 3rd week, respectively. (2) Repeated administration of ketamine produced a significant reduction of the circumference of the arthritic ankle (P<0.05 and P<0.01 with different doses). (3) The body weight of the rats was not affected by continuous administration of ketamine for 4 weeks. No abnormal locomotor behavior was observed (It was concerned but not systemically evaluated in this study). The results suggest that repeated sc injection of ketamine for 4 weeks significantly reduce inflammatory pain in monoarthritis without notable aversive side effects.
authors.affiliation: Neuroscience Research Institute, Beijing Medical University, Peoples Republic of China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: C
authors.initials: C
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
authors.forename: J S
authors.initials: JS
authors.lastname: Han
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000843:Ankle Joint / Q000187:drug effects / Q000473:pathology; D001169:Arthritis, Experimental / Q000150:complications / Q000188:drug therapy*; D001835:Body Weight / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005620:Freund's Adjuvant; D007279:Injections, Subcutaneous; D007649:Ketamine / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D007649:Ketamine; D005620:Freund's Adjuvant