[Evolution of distribution patterns of cis-acting elements in 5' regulative regions of vertebrate actin].
Actins are expressed in a rigorous tissue- and development-manner which implies tthat there most probably are some unique distribution patterns of cis-acting elements in their 5' regulative regions. We improved a method to predict cis-acting element and constructed nucleotide distribution weight matrixes of 5 cis-acting elements which are concerned in vertebrate actin genes' transcription regulation. Using this method, we matched these factors in 5' regulative regions of vertebrate actin genes by comparing the sequences with these matrixes, and got six isotype-specific distribution models of these cis-acting elements. The evolutionary trends of the six models were also analyzed.
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Institute of Basic Medical Sciences, Academy of Military Medical Sciences, National Center of Biomedical Analysis, Beijing, China.
D000199:Actins / Q000235:genetics*; D000818:Animals; D005075:Biological Evolution; D005809:Genes, Regulator; D006801:Humans
D000199:Actins