title: Absolute configuration and antiprotozoal activity of minquartynoic acid.
abstract: Minquartynoic acid (1) was isolated as an antimalarial and antileishmanial constituent of the Peruvian tree Minquartia guianensis and its absolute configuration at C-17 established to be (+)-S through conversion to the known (+)-(S)-17-hydroxystearic acid (2) and confirmed using Mosher's method.
authors.affiliation: Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark.
authors.forename: H B
authors.initials: HB
authors.lastname: Rasmussen
authors.forename: S B
authors.initials: SB
authors.lastname: Christensen
authors.forename: L P
authors.initials: LP
authors.lastname: Kvist
authors.forename: A
authors.initials: A
authors.lastname: Kharazmi
authors.forename: A G
authors.initials: AG
authors.lastname: Huansi
mesh_terms: D000480:Alkynes; D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D018320:Leishmania major / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D053279:Polyynes
chemical_list: D000480:Alkynes; D000981:Antiprotozoal Agents; D005231:Fatty Acids, Unsaturated; C417933:minquartynoic acid; D053279:Polyynes