title: The role of nuclear medicine in inflammatory bowel disease. A review with experiences of aspecific bowel activity using immunoscintigraphy with 99mTc anti-granulocyte antibodies.
abstract: The diagnosis of inflammatory bowel disease (IBD) needs a complex diagnostic work-up. Beside verifying the disease itself, it is fundamental to assess disease extent and activity and to detect associated complications, to find the most effective treatment and for follow up. Scintigraphy with radiolabelled leukocytes is able to provide a complete survey of the whole intestinal tract, both the small and large bowel, and detects septic complications successfully with negligible risk. Radionuclide procedures are useful in establishing or ruling out IBD in patients with intestinal complaints, in assessing disease severity, and in the evaluation of extraintestinal septic complications. Widely available radionuclide procedures are discussed, i.e. scintigraphy by 111Indium oxime or 99mTechnetium HMPAO labelled white blood cells and immunoscintigraphy with 99mTc anti-granulocyte antibodies. Advantages and disadvantages of all three methods are stressed out.
  
  
  METHODS
  The immunoscintigraphies with 99mTc anti-granulocyte antibodies (ANTI-GRANULOCYTE(R) BW 250/183) of 27 patients with suspicion of IBD were retrospectively analysed. Planar anterior and posterior images were obtained 4 and 24 h postinjection, respectively. The bowel was divided into six segments and the activity was visually graded with reference to bone marrow in each segments. The scans were compared with the results of radiological and endoscopical investigations. The diagnosis of IBD was proved or ruled out by means of enteroclysis, large bowel enema or endoscopy.
  
  
  RESULTS
  In the 27 patients, 74 bowel segments with increased activity were detected. In the case of 30 segments in 16 patients, bowel inflammation was revealed by the other methods (true positives). In the case of 44 bowel segments, no underlying bowel inflammation could be verified, and these activities were regarded as aspecific activity. We could not differentiate between true positive and aspecific activity based on scan pattern or intensity.
  
  
  CONCLUSIONS
  These findings of aspecific bowel activity using imuunoscintigraphy are in contrast with the results of former studies, while the existence of non-specific activity decreases the reliability of the method. Based on the literature and our experiences, we conclude that 99mTc HMPAO labelling should be the method of choice for the investigation of IBD patients.
authors.affiliation: Semmelweis University, Budapest Faculty of Medicine, Department of Diagnostic Radiology and Oncotherapy, Ullöi út 78/a, H-1082, Budapest, Hungary. gyorke@radi.sote.hu
authors.forename: T
authors.initials: T
authors.lastname: Györke
authors.forename: L
authors.initials: L
authors.lastname: Duffek
authors.forename: K
authors.initials: K
authors.lastname: Bártfai
authors.forename: E
authors.initials: E
authors.lastname: Makó
authors.forename: K
authors.initials: K
authors.lastname: Karlinger
authors.forename: A
authors.initials: A
authors.lastname: Mester
authors.forename: Z
authors.initials: Z
authors.lastname: Tarján
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008297:Male; D016719:Radioimmunodetection; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013667:Technetium; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000911:Antibodies, Monoclonal; C104213:BW 250 183; D007205:Indium Radioisotopes; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D013667:Technetium