title: Determination of the place conditioning and locomotor effects of amperozide in rats: a comparison with cocaine.
abstract: Amperozide promotes social interactions in rats (Rattus norvegicus) and reduces craving for cocaine and alcohol without producing adverse side effects. Amperozide administration produced a place preference in the dose range from 3.0 to 10.0 mg/kg. Locomotor behavior tended to be suppressed on the days of amperozide pairings, elevated on the days of vehicle pairings, and elevated on test days. Administration of 20.0 mg/kg but neither 2.0 nor 0.2 mg/kg cocaine produced place preference. Rats exhibited a greater place preference for the chamber paired with 2.0 mg/kg and 20.0 mg/kg but not 0.2 mg/kg cocaine compared to the chamber paired with 5.0 mg/kg amperozide. The results indicate that amperozide is appetitive. The most appetitive dose of amperozide (5.0 mg/kg) is less appetitive than the most appetitive dose of cocaine (20.0 mg/kg). More research is needed before conclusions regarding the degree of abuse potential for amperozide can be made.
authors.affiliation: Department of Psychology, University of Wisconsin--Milwaukee, 53211, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Rademacher
authors.forename: K A
authors.initials: KA
authors.lastname: Anders
authors.forename: M G
authors.initials: MG
authors.lastname: Riley
authors.forename: J T
authors.initials: JT
authors.lastname: Nesbitt
authors.forename: R E
authors.initials: RE
authors.lastname: Steinpreis
mesh_terms: D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012702:Serotonin Antagonists / Q000494:pharmacology*
chemical_list: D018765:Dopamine Uptake Inhibitors; D010879:Piperazines; D012702:Serotonin Antagonists; C049058:amperozide; D003042:Cocaine