STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene.
The repeated occurrence of genes in each other's neighbourhood on genomes has been shown to indicate a functional association between the proteins they encode. Here we introduce STRING (search tool for recurring instances of neighbouring genes), a tool to retrieve and display the genes a query gene repeatedly occurs with in clusters on the genome. The tool performs iterative searches and visualises the results in their genomic context. By finding the genomically associated genes for a query, it delineates a set of potentially functionally associated genes. The usefulness of STRING is illustrated with an example that suggests a functional context for an RNA methylase with unknown specificity.
Snel
B
B
European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. snel@embl-heidelberg.de
Lehmann
G
G
Bork
P
P
Huynen
M A
MA
D005798:Genes, Bacterial / Q000502:physiology; D016247:Information Storage and Retrieval; D020407:Internet; D009174:Mycoplasma / Q000201:enzymology / Q000235:genetics; D009876:Operon; D012984:Software; D013379:Substrate Specificity; D012359:tRNA Methyltransferases / Q000378:metabolism
D012359:tRNA Methyltransferases