Systematic percutaneous fluoroscopic gastrostomy for concomitant radiochemotherapy of advanced head and neck cancer: optimization of therapy.
Wasting is a major complication of advanced head and neck cancer. Concomitant chemotherapy and twice-daily continuous radiotherapy with no acceleration represents a promising treatment modality for these tumors, but increases the risk of mucositis. This report describes the results achieved with percutaneous fluoroscopic gastrostomy (PFG) and its impact on the quality of life of patients with head and neck cancer in terms of their nutritional status. A total of 50 stage IV tumors of the oropharynx and hypopharynx recorded in a prospective database were reviewed retrospectively. All patients were managed by PFG, which was found to be a safe and effective technique with no technical failures. PFG feeding resulted in a mean increase in body weight of 2.5 kg within 3 weeks. The body mass index (BMI) was maintained at 3 and 6 weeks. Minor complications occurred, but no major complications were noted. The overall procedure-related mortality rate was nil. Further prospective investigations are necessary to determine whether treatment of wasting improves patient survival.
Marcy
P Y
PY
Centre Antoine Lacassagne, Nice, France. pierre-yves.marcy@cal.nice.fnclcc.fr
Magné
N
N
Bensadoun
R J
RJ
Bleuse
A
A
Falewee
M N
MN
Viot
M
M
Bruneton
J N
JN
D000328:Adult; D000368:Aged; D001835:Body Weight; D002100:Cachexia / Q000209:etiology / Q000517:prevention & control*; D003131:Combined Modality Therapy; D064420:Drug-Related Side Effects and Adverse Reactions; D004750:Enteral Nutrition; D005260:Female; D005471:Fluoroscopy / Q000379:methods; D005774:Gastrostomy / Q000379:methods*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D013280:Stomatitis / Q000517:prevention & control