title: BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.
authors.affiliation: BioCryst Pharmaceuticals, Inc., 2190 Parkway Lake Drive, Birmingham, Alabama 35244, USA. babu@biocryst.com
authors.forename: Y S
authors.initials: YS
authors.lastname: Babu
authors.forename: P
authors.initials: P
authors.lastname: Chand
authors.forename: S
authors.initials: S
authors.lastname: Bantia
authors.forename: P
authors.initials: P
authors.lastname: Kotian
authors.forename: A
authors.initials: A
authors.lastname: Dehghani
authors.forename: Y
authors.initials: Y
authors.lastname: El-Kattan
authors.forename: T H
authors.initials: TH
authors.lastname: Lin
authors.forename: T L
authors.initials: TL
authors.lastname: Hutchison
authors.forename: A J
authors.initials: AJ
authors.lastname: Elliott
authors.forename: C D
authors.initials: CD
authors.lastname: Parker
authors.forename: S L
authors.initials: SL
authors.lastname: Ananth
authors.forename: L L
authors.initials: LL
authors.lastname: Horn
authors.forename: G W
authors.initials: GW
authors.lastname: Laver
authors.forename: J A
authors.initials: JA
authors.lastname: Montgomery
mesh_terms: D000146:Acids, Carbocyclic; D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006146:Guanidines; D009980:Influenza A virus / Q000201:enzymology*; D009981:Influenza B virus / Q000201:enzymology*; D051379:Mice; D008958:Models, Molecular; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D011485:Protein Binding; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D006146:Guanidines; D009439:Neuraminidase; C414210:peramivir