title: [Thromboangiitis obliterans].
abstract: Thromboangiitis obliterans (Buerger disease) is a rare vascular disease, characterized by a multilocular, segmental, non-arteriosclerotic, thrombotic inflammation of small and medium size arterial and venous vessels and nerves. The precise etiology is unknown, but there is a cause-effect relationship with tobacco smoking. Autoimmunological, immunogenetic, infectious and hemostatic processes have been discussed as pathogenetic factors. The clinical picture is typically characterized by acrally localized, non-healing ulcerations, which frequently prompt patients to see a dermatologist. We present two patients with thromboangiitis obliterans and discuss the clinical features, the resulting differential diagnostic spectrum and possible therapeutic approaches.
authors.affiliation: Hautklinik, Heinrich-Heine-Universität Düsseldorf.
authors.forename: W
authors.initials: W
authors.lastname: Franke
authors.forename: K W
authors.initials: KW
authors.lastname: Schulte
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: J
authors.initials: J
authors.lastname: Krutmann
mesh_terms: D000328:Adult; D015901:Angiography, Digital Subtraction; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008160:Lumbosacral Plexus / Q000601:surgery; D008297:Male; D013562:Sympathectomy; D013919:Thromboangiitis Obliterans / Q000175:diagnosis / Q000628:therapy; D013997:Time Factors