Proteomics: the industrialization of protein chemistry.
Establishing a proteomics platform in the industrial setting initially required implementation of a series of robotic systems to allow a high-throughput approach to analysis and identification of differences observed on 2-D electrophoresis gels. Now, a simpler alternative approach employing chromatography-based systems is emerging for identification of many components of complex mixtures, which can also provide quantitative comparisons through the use of a new labeling methodology.
Patterson
S D
SD
Amgen Inc, Biochemistry, Thousand Oaks, California 91320-1789, USA. spatters@amgen.com
D001331:Automation; D002845:Chromatography / Q000379:methods*; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods*; D007553:Isotope Labeling / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D011506:Proteins / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism
D011506:Proteins