Gene therapy of hypertensive vascular injury.
Hypertension and vascular injury usually require prolonged treatment, and compliance is a key to efficacy for pharmacologically-based antihypertensive therapy. Gene therapy has the potential to be long lasting, with few side effects. Recent studies have provided promising results, in which hypertension can be treated by either augmentation of vasodilation or inhibition of vasoconstriction through gene transfer in experimental models. Gene transfer is also becoming useful for the study of mechanisms of physiologic and pathophysiologic conditions, including hypertension. In this mini-review, we summarize some recent studies in this area of research, and suggest some areas where progress is needed to advance the research toward gene therapy.
Chu
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Cardiovascular Center, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
Faraci
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Heistad
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D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D006973:Hypertension / Q000473:pathology / Q000628:therapy*; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000627:therapeutic use; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology
D014665:Vasodilator Agents