Chronic administration of interferon-a decreases blood pressure and heart rate in rats.
We studied the effects of interferon-alpha on rat cardiovascular system. Intravenous administration of intron-A in a dose of 100,000 IU/kg for 3 days led to a permanent and statistically significant decrease in blood pressure (on days 2 and 3) and reduction in heart rate. These effects were not associated with changes in baroreflex regulation of the cardiovascular system.
Gavrilova
S A
SA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University. gavrusa@3.human.bio.msu.ru
Demidov
L V
LV
Medvedeva
N A
NA
Ashmarin
I P
IP
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D007155:Immunologic Factors / Q000008:administration & dosage*; D016898:Interferon-alpha / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007155:Immunologic Factors; D016898:Interferon-alpha