The musculoskeletal manifestations of Werner's syndrome.
Werner's syndrome is a rare condition usually presenting as premature ageing in adults. Over a period of 30 years we have followed two siblings with extensive musculoskeletal manifestations including a soft-tissue tumour, insufficiency fractures, nonunion and tendonitis, with associated problems of management. The literature is reviewed.
Walton
N P
NP
Department of Orthopaedics, Queen Elizabeth Hospital, King's Lynn, Norfolk, England.
Brammar
T J
TJ
Coleman
N P
NP
D005260:Female; D017102:Fracture Healing; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D005599:Fractures, Ununited / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D006215:Hallux Valgus / Q000209:etiology / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D006801:Humans; D008159:Lumbar Vertebrae; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D010024:Osteoporosis / Q000209:etiology; D011859:Radiography; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D013168:Spondylolisthesis / Q000209:etiology; D052256:Tendinopathy / Q000209:etiology; D014898:Werner Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics