Traffic exposure and allergic sensitization against latex in children.
BACKGROUND
Latex antigens have been found in urban air samples and in debris deposited near freeways.


OBJECTIVE
We investigated whether exposure to road traffic in a large city is associated with allergic sensitization against latex in children.


METHODS
A population-based sample of 2505 children aged 5 to 11 years was examined in a cross-sectional study in the city of Dresden, Germany. Specific IgE levels against latex and a panel of common aeroallergens (timothy grass, rye, birch, mugwort, Cladosporium herbarum, Dermatophagoides pteronyssinus, cat dander, and dog dander) was determined by using a fluorescence immunoassay (CAP Pharmacia). Traffic exposure was assessed by (1) parental self-report on traffic frequency and truck traffic in the street of residence, (2) traffic counts, and (3) measurements of benzene at 182 points on a 1-km(2) grid for 1 year, which were used to estimate the children's individual exposure at the home address.


RESULTS
Eight hundred fifty-four (34.1%) of the children were sensitized against any of the allergens, and 150 (6.0%) had specific IgE (>0.35 kU/L) against latex. The prevalence of latex sensitization was not positively associated with self-reported traffic exposure, traffic counts in the street of residence (adjusted prevalence odds ratio for >5000 vs < or =5000 cars/d, 0.7; 95% confidence interval, 0.4-1.3), or benzene exposure (adjusted prevalence odds ratio for an increase of 1 microg/m(3) air, 0.8; 95% confidence interval, 0.7-1.05).


CONCLUSIONS
The data suggest that exposure to road traffic is not associated with allergic sensitization to latex in children.
Hirsch
T
T
University Children's Hospital of the University of Technology, Dresden, Germany.
Neumeister
V
V
Weiland
S K
SK
von Mutius
E
E
Hirsch
D
D
Gräfe
H
H
Duhme
H
H
Leupold
W
W
D001336:Automobiles; D001554:Benzene / Q000009:adverse effects; D002648:Child; D005260:Female; D005858:Germany; D006801:Humans; D007114:Immunization; D020315:Latex Hypersensitivity / Q000276:immunology*; D008297:Male; D012130:Respiratory Hypersensitivity / Q000276:immunology; D011795:Surveys and Questionnaires
D001554:Benzene