title: The T-cell protein tyrosine phosphatase.
abstract: In recent years, the T-cell protein tyrosine phosphatase (TC-PTP) has become an important member of the protein-tyrosine phosphatase (PTP) family in two aspects. Firstly, TC-PTP has been reported to act on downstream signalling events initiated by the epidermal growth receptor, suggesting that it may act as an important modulator of receptor tyrosine kinases and mitogenic signalling. Secondly, the finding of immune deficiency and lethality observed in TC-PTP null mice emphasizes the importance of this small PTP in the hematopoietic system. In this review, we provide a summary of the recent literature published on the TC-PTP and its various orthologs. Although much remains to be uncovered, some recent findings on the function of this small PTP suggest that it plays a critical role in regulating mammalian cell signalling.
authors.affiliation: Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Ibarra-Sánchez
authors.forename: P D
authors.initials: PD
authors.lastname: Simoncic
authors.forename: F R
authors.initials: FR
authors.lastname: Nestel
authors.forename: P
authors.initials: P
authors.lastname: Duplay
authors.forename: W S
authors.initials: WS
authors.lastname: Lapp
authors.forename: M L
authors.initials: ML
authors.lastname: Tremblay
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017027:Protein Tyrosine Phosphatases / Q000276:immunology*; D016415:Sequence Alignment; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D017027:Protein Tyrosine Phosphatases