The murine Bis1 seizure gene and the Kcnab2 gene encoding the beta2-subunit of the K+ channel are different.
We tested the hypothesis that Bis1, a gene involved in seizure regulation in mice which has been localized to the distal part of chromosome 4, was the same as the gene Kcnab2, encoding the beta2-subunit for voltage-dependent K+ channels. Two facts suggested this hypothesis: Kcnab2 is located in the 3.1-cM confidence interval containing Bis1 and many studies have shown an involvement of K+ channels in the genesis of seizures. DNA sequence analysis of the coding sequence for Kcnab2 from JE/Le mice revealed no structural alterations which might affect Kcnab2 function. However, several nucleotide changes were observed.
Zerr
P
P
Vollum Institute, Oregon Health Science University, Portland 97201, USA.
Martin
B
B
Adelman
J P
JP
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D016001:Confidence Intervals; D051379:Mice; D008818:Mice, Neurologic Mutants; D015221:Potassium Channels / Q000737:chemistry / Q000235:genetics*; D021122:Protein Subunits; D012640:Seizures / Q000235:genetics*
D015221:Potassium Channels; D021122:Protein Subunits