Effect of semisynthetic analog of alpha(1)-acid glycoprotein on immunomodulatory and antiinflammatory activity of natural glycoprotein.
Pseudo-alpha(1)-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of alpha(1)-acid glycoprotein carbohydrate chains to other polymeric carrier. Similarly to native glycoprotein, the semisynthetic analog inhibited lymphocyte proliferation and stimulated the production of antiinflammatory cytokines by peripheral blood mononuclear leukocytes. However, it possessed no antioxidant activity and did not inhibit complement activation by the alternative pathway. The role of carbohydrate and protein components of alpha(1)-acid glycoprotein molecule in the realization of its biological effects is discussed.
Pukhal'skii
A L
AL
Research Center of Medicogenetics, Russian Academy of Medical Sciences, Moscow.
Shmarina
G V
GV
Kalashnikova
E A
EA
Shiyan
S D
SD
Kokarovtseva
S N
SN
Pukhal'skaya
D A
DA
Bovin
N V
NV
D004347:Drug Interactions; D006801:Humans; D007249:Inflammation; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology*; D009961:Orosomucoid / Q000031:analogs & derivatives / Q000276:immunology* / Q000494:pharmacology*; D010455:Peptides / Q000276:immunology / Q000494:pharmacology
D009961:Orosomucoid; D010455:Peptides