Towards enzyme activated antiprostatic agents.
A prodrug conjugate designed to undergo activation by enzymatic prostate specific antigen has been synthesized. The prodrug system undergoes activation with PSA or alpha-chymotrypsin, and shows selective cytotoxicity in a PSA secreting cell line.
Jones
G B
GB
Department of Chemistry, Northeastern University, Boston, MA 02115, USA. grjones@lynx.neu.edu
Mitchell
M O
MO
Weinberg
J S
JS
D'Amico
A V
AV
Bubley
G J
GJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008297:Male; D011355:Prodrugs / Q000138:chemical synthesis*; D017430:Prostate-Specific Antigen / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D011355:Prodrugs; D017430:Prostate-Specific Antigen