Traceless solid-phase synthesis of heterosteroid framework.
[reaction: see text]A traceless solid-phase synthesis of cyclopenta[c]-4H-chromen-8-ol, benzo[d]cyclopenta[e]-3H-3-azin-8-ol, and other 11-heterosteroids via the fulvene hetero [6 + 3] cycloaddition is described.
Hong
B C
BC
Department of Chemistry, National Chung Cheng University, Taiwan, ROC. chebch@ccunix.ccu.edu.tw
Chen
Z Y
ZY
Chen
W H
WH
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D003517:Cyclopentanes / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D007202:Indicators and Reagents; D011804:Quinolines / Q000138:chemical synthesis*; D013256:Steroids / Q000138:chemical synthesis*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001578:Benzopyrans; D003517:Cyclopentanes; D007202:Indicators and Reagents; D011804:Quinolines; D013256:Steroids; C414387:benzo(d)cyclopenta(e)-3H-azin-8-ol; C414386:cyclopenta(c)-4H-chromen-8-ol; C017332:fulvene