title: Homology-independent protein engineering.
abstract: Is structure, rather than sequence, the key to the successful generation of truly novel proteins? While protein evolution by homologous recombination has become an established tool to explore confined regions in sequence space, the generation of functional hybrid proteins by homology-independent methods further expands the scope of protein engineering.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park 16802-6300, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lutz
authors.forename: S J
authors.initials: SJ
authors.lastname: Benkovic
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004798:Enzymes / Q000235:genetics / Q000378:metabolism*; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D004798:Enzymes; D011506:Proteins