title: Failure of long-term pallidal stimulation corrected by subthalamic stimulation in PD.
abstract: Bilateral high-frequency continuous stimulation of the internal globus pallidus or subthalamic nucleus constitutes a new therapeutic approach for the treatment of patients with severe PD. The authors report two patients in whom stimulation of the globus pallidus failed to give long-term relief and was successfully replaced by bilateral subthalamic stimulation. The results emphasize the reversibility of deep brain stimulation therapy and suggest that the subthalamic target is preferable to the pallidal target.
authors.affiliation: Centre d'Investigation Clinique, Fédération de Neurologie and INSERM 289, Hôpital de la Salpêtrière, Paris, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Houeto
authors.forename: P B
authors.initials: PB
authors.lastname: Bejjani
authors.forename: P
authors.initials: P
authors.lastname: Damier
authors.forename: C
authors.initials: C
authors.lastname: Staedler
authors.forename: A M
authors.initials: AM
authors.lastname: Bonnet
authors.forename: B
authors.initials: B
authors.lastname: Pidoux
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: P
authors.initials: P
authors.lastname: Cornu
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
mesh_terms: D004558:Electric Stimulation; D005260:Female; D005917:Globus Pallidus / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D013997:Time Factors