title: Bartter syndrome and focal segmental glomerulosclerosis: a possible link between two diseases.
abstract: We describe a patient with signs and symptoms of classic Bartter syndrome. The patient tested negative for all known genetic abnormalities associated with this tubular disorder. Proteinuria was found within 1 year after the diagnosis of Bartter syndrome. A renal biopsy performed 6 months later, when her kidney function was normal, revealed focal segmental glomerulosclerosis (FSGS). We propose a link between stimulation of the renin-angiotensin system and sclerotic changes in the glomerulus. This lesion may explain previous reports of kidney failure in patients with Bartter syndrome.
authors.affiliation: Division of Pediatric Nephrology, Schneider Children's Hospital of the North Shore-LIJ Health System, Albert Einstein College of Medicine, New Hyde Park, NY 11040-1432, USA.
authors.forename: I H
authors.initials: IH
authors.lastname: Su
authors.forename: R
authors.initials: R
authors.lastname: Frank
authors.forename: B G
authors.initials: BG
authors.lastname: Gauthier
authors.forename: E
authors.initials: E
authors.lastname: Valderrama
authors.forename: D B
authors.initials: DB
authors.lastname: Simon
authors.forename: R P
authors.initials: RP
authors.lastname: Lifton
authors.forename: H
authors.initials: H
authors.lastname: Trachtman
mesh_terms: D000293:Adolescent; D001477:Bartter Syndrome / Q000150:complications* / Q000473:pathology / Q000652:urine; D001706:Biopsy; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D011507:Proteinuria / Q000209:etiology