Augmentation strategies for inadequate antidepressant response: a review of placebo-controlled studies.
Uncontrolled trials of strategies directed at inadequate antidepressant response are prone to falsely positive results. Most of those studies which have used placebo control have assessed augmentation and the addition of lithium to tricyclic antidepressants or serotonin reuptake inhibitors has so far received the most support. A smaller literature shows promise for augmentation with triiodothyronine, pindolol and dehydroepiandrosterone.
Coryell
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University of Iowa College of Medicine, Psychiatry Research-MEB, Iowa City 52242-1000, USA.
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000627:therapeutic use*; D003687:Dehydroepiandrosterone / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D010869:Pindolol / Q000494:pharmacology / Q000627:therapeutic use*; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D014284:Triiodothyronine; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D010919:Placebos; D014665:Vasodilator Agents; D014284:Triiodothyronine; D003687:Dehydroepiandrosterone; D010869:Pindolol