5-HETE congeners as modulators of cell proliferation.
The synthesis and assessment of the mitogenic properties of 5-HETE congeners are reported. These studies represent an effort to develop a structure-activity profile for ligands of the 5-HETE/5-oxoETE G-protein coupled receptor(s). Many of these agents possess mitogenic activity that equals or exceeds that of racemic 5-HETE family constituents in prostate cancer cell lines.
Miller
T A
TA
Departnent of Chemistry, University of Virginia, Charlottesville 22901, USA.
Ghosh
J
J
Myers
C E
CE
Macdonald
T L
TL
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000494:pharmacology*; D008934:Mitogens / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D006893:Hydroxyeicosatetraenoic Acids; D008934:Mitogens; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid