[Effect of low concentration benzene vapor on metabolism of gamma-aminobutyric acid in brain mitochondrial fractions].
The impact of benzene vapor (0.35 mg/l) of low concentration on the contents of free GABA, Glu and Asp, as well as on the enzyme activities of GDC and GABA-T in mitochondrial fractions of different brain regions of adult male rats was investigated. The conclusion was put forward that GABA increase by means of "keeping" inhibition provided for nerve cells defense from extremal excitation, taking place under the chronic exposure to the benzene low concentration.
Safarov
M I
MI
A. I. Karayev Institute of Physiology, Azerbaijan Academia of Sciences, Baku. inphys@dcaes.ab.az
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D001554:Benzene / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005968:Glutamate Decarboxylase / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D000612:4-Aminobutyrate Transaminase; D005968:Glutamate Decarboxylase; D001554:Benzene