title: Age and other risk factors for neuropsychologic decline in patients undergoing coronary artery bypass graft surgery.
abstract: OBJECTIVE
  To evaluate if increasing age is a major determinant of long-term neuropsychologic (NP) dysfunction in patients undergoing coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  A single university hospital.
  
  
  METHODS
  Three hundred eighty-one patients undergoing elective CABG surgery.
  
  
  METHODS
  Baseline preoperative and intraoperative characteristics were assessed for all patients. A comprehensive NP test battery was conducted preoperatively and at 1 month postoperatively.
  
  
  RESULTS
  Of the initial 381 patients, 319 (84%) returned for the 1-month visit. The overall incidence of an NP deficit was 21.6%. There was no significant difference seen with increasing age, although a trend was observed with highest NP deficit rate in the older than 65 age group. Other preoperative risk factors, including gender, education level, and preexisting diseases, were nonsignificant. Intraoperative variables were evaluated and revealed no significant differences across the age groups.
  
  
  CONCLUSIONS
  This cohort study did not find an increased incidence of NP deficits in elderly patients after CABG surgery. It has addressed the limitations of other studies, however, with (1) a comprehensive NP test battery, (2) longer-term follow-up, and (3) adequate sample size.
authors.affiliation: Department of Anesthesia, University of Western Ontario, LHSC-UC, London, Ontario.
authors.forename: M H
authors.initials: MH
authors.lastname: Smith
authors.forename: L E
authors.initials: LE
authors.lastname: Wagenknecht
authors.forename: C
authors.initials: C
authors.lastname: Legault
authors.forename: D C
authors.initials: DC
authors.lastname: Goff
authors.forename: D A
authors.initials: DA
authors.lastname: Stump
authors.forename: B T
authors.initials: BT
authors.lastname: Troost
authors.forename: A T
authors.initials: AT
authors.lastname: Rogers
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D015331:Cohort Studies; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000209:etiology*; D011597:Psychomotor Performance; D012307:Risk Factors