Naproxen-associated linear IgA bullous dermatosis: case report and review.
Linear IgA bullous dermatosis (LABD) is an acquired autoimmune subepidermal blistering disorder in which linear deposits of IgA are found along the basement membrane. Idiopathic, systemic disorder-related, and drug-induced forms of LABD have been described. Drug-induced LABD occurs in association with drug administration and resolves when the offending agent is discontinued. Other forms of LABD assume a more chronic course. The nonsteroidal anti-inflammatory drugs piroxicam and diclofenac have been previously reported to induce LABD. To our knowledge, this article describes the first documented case of LABD associated with naproxen administration, which resolved after discontinuation of the drug.
Bouldin
M B
MB
Department of Dermatology, Mayo Clinic, Rochester, Minn 55905, USA.
Clowers-Webb
H E
HE
Davis
J L
JL
McEvoy
M T
MT
Davis
M D
MD
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001706:Biopsy; D004008:Diclofenac / Q000009:adverse effects; D006801:Humans; D007070:Immunoglobulin A; D008297:Male; D009288:Naproxen / Q000009:adverse effects*; D010894:Piroxicam / Q000009:adverse effects; D011241:Prednisone / Q000627:therapeutic use; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007070:Immunoglobulin A; D010894:Piroxicam; D004008:Diclofenac; D009288:Naproxen; D011241:Prednisone