title: A low-glycemic index diet in the treatment of pediatric obesity.
abstract: BACKGROUND
  Conventional dietary approaches for the treatment of obesity have generally yielded disappointing results.
  
  
  OBJECTIVE
  To examine the effects of a low-glycemic index (GI) diet compared with a standard reduced-fat diet in the management of pediatric obesity.
  
  
  METHODS
  Retrospective cohort study of children attending an outpatient pediatric obesity program from September 1997 to December 1998.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  One hundred seven obese but otherwise healthy children.
  
  
  METHODS
  Changes in body mass index (BMI [calculated as weight in kilograms divided by the square of height in meters]) and body weight from first to last clinic visit.
  
  
  RESULTS
  A total of 64 patients received the low glycemic index diet and 43 received the reduced-fat diet for 4.3 vs 4.2 months' mean duration of follow-up, with 3.3 vs 3.3 mean number of visits, respectively. Body mass index (-1.53 kg/m(2) [95% confidence interval, -1.94 to -1.12] vs -0.06 kg/m(2) [-0.56 to + 0. 44], P<.001) and body weight (-2.03 kg [95% confidence interval -3. 19 to -0.88] vs +1.31 kg [ -0.11 to + 2.72], P<.001) decreased more in the low-GI group compared with the reduced-fat group. In multivariate models, these differences remained significant (P<.01) after adjustment for age, sex, ethnicity, BMI or baseline weight, participation in behavioral modification sessions, and treatment duration. Significantly more patients in the low-GI group experienced a decrease in BMI of at least 3 kg/m(2) (11 kg/m(2) [17. 2%] vs. 1 kg/m(2) [2.3%], P =.03).
  
  
  CONCLUSIONS
  A low-GI diet seems to be a promising alternative to standard dietary treatment for obesity in children. Long-term randomized controlled trials of a low-GI diet in the prevention and treatment of obesity are needed.
authors.affiliation: Department of Medicine, Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Spieth
authors.forename: J D
authors.initials: JD
authors.lastname: Harnish
authors.forename: C M
authors.initials: CM
authors.lastname: Lenders
authors.forename: L B
authors.initials: LB
authors.lastname: Raezer
authors.forename: M A
authors.initials: MA
authors.lastname: Pereira
authors.forename: S J
authors.initials: SJ
authors.lastname: Hangen
authors.forename: D S
authors.initials: DS
authors.lastname: Ludwig
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D018752:Diet, Fat-Restricted / Q000379:methods*; D004038:Diet, Reducing / Q000379:methods*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000175:diagnosis / Q000178:diet therapy* / Q000378:metabolism; D012189:Retrospective Studies; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D007328:Insulin