[Clinical manifestations and biological markers in the natural history of HIV-1 infection in vertically infected children. Longitudinal study].
OBJECTIVE
To study the relationship among clinical symptoms and biological markers as predictive value of progression to death in HIV-1 vertically infected infants.


METHODS
We carry out a prospective study in 43 HIV-1 infants with a mean age of 4.27 (range: 0-11.8 months). None of the infants' mothers had received any antiviral treatment during pregnancy. None of the infants were breastfed. They were routinely assessed for clinical symptoms during follow-up.


RESULTS
Cox regression analysis was used to study the hazard ratio (HR) of progression to death. For the median viral load > 5 log10, the HR was 6.42 (95% CI, 1.28-32.03) (p = 0.023) and 6.84 (95% CI, 1.52-30,69) (p = 0.012) for biological phenotype of viral isolates with rapid replication and high titter (R/H-X4). We also study the predictive value of the clinical symptoms and we observe that the symptoms with more HR of progression to death were the progressive encephalopathy (3.60 [95% CI, 0.92-14.06; p = 0.065]) and the cardiopathy (6.29 [95% CI, 1.59-24.85; p = 0.008]).


CONCLUSIONS
Our data indicate that viral load > 5 log10 and biological phenotype R/H-X4 of virus isolates along the study are predictive markers of progression to death. In addition, the progressive encephalopathy and cardiopathy were also markers of progression death.
Resino
S
S
Servicio de Inmunología. Hospital Central Universitario Gregorio Marañón, Madrid.
Bellón
J M
JM
Jiménez
J L
JL
Gurbindo
D
D
Muñoz-Fernández
M A
MA
D015415:Biomarkers; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000401:mortality* / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008137:Longitudinal Studies; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis
D015415:Biomarkers