title: [The synthesis and study of the trichinellacidal activity of bromine and chlorine derivatives of 8-quinolyloxysalicylanilides].
abstract: Some new bromine (chlorine) derivatives of 8-quinolyloxysalicylanilides were synthesized and tested for trichinellacidal activity. Among them there was the substance N-[3-bromophenyl-4-(5-chloroquinolinoxy)]-3,5-dibromosalicylami de which exhibited its high trichinellocidal activity (in albino mice infected with decapsulated Trichinella spiralis) that was close to that of mebendazole.
authors.forename: S N
authors.initials: SN
authors.lastname: Trusov
authors.forename: D P
authors.initials: DP
authors.lastname: Sevbo
authors.forename: N L
authors.initials: NL
authors.lastname: Veretennikova
authors.forename: F S
authors.initials: FS
authors.lastname: Mikhaĭlitsyn
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D008463:Mebendazole / Q000627:therapeutic use; D051379:Mice; D012458:Salicylanilides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D017160:Trichinella spiralis / Q000187:drug effects*; D014235:Trichinellosis / Q000188:drug therapy
chemical_list: D000969:Antinematodal Agents; D012458:Salicylanilides; D008463:Mebendazole