Increased serum level of vascular endothelial growth factor in pulmonary tuberculosis.
Pulmonary tuberculosis, one of the granulomatous diseases, has few serological markers for its activity. Recently, an increased serum level of vascular endothelial growth factor (VEGF) was detected in patients with Crohn's disease, also a granulomatous disease. We hypothesized that VEGF might be associated with the pathogenesis of pulmonary tuberculosis. We investigated the serum level of VEGF in 43 patients with active pulmonary tuberculosis, 29 patients with old tuberculosis, and 25 patients with acute bronchitis. We were able to examine the serum VEGF levels every 3 mo for a period of 6 mo in seven patients with active pulmonary tuberculosis. We examined the presence of VEGF in the resected lungs of three patients with active pulmonary tuberculosis by immunohistochemistry. The serum levels of VEGF were significantly higher in patients with active pulmonary tuberculosis than in patients with old tuberculosis and acute bronchitis. The decrease in titer of serum VEGF paralleled the clinical improvement of patients with pulmonary tuberculosis. Immunohistochemical staining of the resected lungs demonstrated the presence of VEGF in alveolar macrophages surrounding the lesion. Therefore, VEGF may be associated with the pathogenesis of pulmonary tuberculosis.
Matsuyama
W
W
The Third Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima City, Japan; The Department of Respiratory Medicine, and The Department of Thoracic Surgery, National Minami-kyushu Hospital, Aira-gun, Kag.
Hashiguchi
T
T
Matsumuro
K
K
Iwami
F
F
Hirotsu
Y
Y
Kawabata
M
M
Arimura
K
K
Osame
M
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001991:Bronchitis / Q000097:blood / Q000473:pathology; D016228:Endothelial Growth Factors / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008222:Lymphokines / Q000502:physiology*; D016676:Macrophages, Alveolar / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors