The chimpanzee and other non-human-primate models in HIV-1 vaccine research.
Animal models are of great importance for the study of disease pathogenesis, particularly non-human-primate models of infectious diseases. The role of non-human primates in HIV-1 research is continually discussed and debated. Here, we examine three primate models: chimpanzee-HIV-1, rhesus macaque-simian immunodeficiency virus and rhesus macaque-SHIV, and discuss immunological similarities and differences, safety and monetary issues, and ethical concerns.
Nath
B M
BM
Dept of Pathology and Laboratory Medicine, University of Pennsylvania, 505 Stellar Chance, 422 Curie Blvd, Philadelphia, PA 19104, USA.
Schumann
K E
KE
Boyer
J D
JD
D016915:AIDS Vaccines; D000818:Animals; D004195:Disease Models, Animal; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1; D008251:Macaca / Q000821:virology; D002679:Pan troglodytes / Q000821:virology; D011323:Primates / Q000821:virology*; D012106:Research; D016097:Simian Acquired Immunodeficiency Syndrome; D015302:Simian Immunodeficiency Virus
D016915:AIDS Vaccines