Rho family GTPases: more than simple switches.
Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In this review, we discuss the signal-transduction mechanisms that control these regulators. We will emphasize the subcellular localization of Rho GTPases and their regulatory proteins and the role of GTP hydrolysis in signal transmission.
Symons
M
M
Picower Institute for Molecular Research, 350 Community Drive, Manhasset, NY 11030, USA. msymons@picpower.edu
Settleman
J
J
D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism*
D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D020741:rho GTP-Binding Proteins