CD8+ T cell populations in common variable immunodeficiency.
In a subgroup of CVID T cell abnormalities have been reported. Peripheral blood T lymphocytes from patients with common variable immunodeficiency (CVID) and blood donors were examined for expression of CD8alpha, CD8beta and CD28. In CVID, three CD8+ T cells could be defined: CD8beta(high)CD28+ (expressing CD8beta at a high median fluorescence intensity), CD8beta(low)CD28+ and CD8beta(low) CD28- cells. The number of CD8beta(low) cells was markedly increased compared to blood donors. After activation, CD8beta(high)CD28+ cells from cord blood differentiated into CD8beta(low) CD28- cells. Therefore, CD8beta(low) cells are induced by activation even in normal donors, but may reflect inflammatory activity in CVID.
Werwitzke
S
S
Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Germany.
Drescher
B
B
Schmidt
R E
RE
Witte
T
T
D018414:CD8-Positive T-Lymphocytes / Q000145:classification* / Q000166:cytology; D017074:Common Variable Immunodeficiency / Q000097:blood / Q000276:immunology*; D005434:Flow Cytometry / Q000379:methods; D006801:Humans