title: Opposite effects of dexamethasone on antitumor and natural suppressor activities of bone marrow cells.
abstract: Effects of dexamethasone on the ability of nonadherent bone marrow cells to inhibit proliferation of mastocytoma P815 cells and concanavalin A-stimulated proliferation of syngeneic splenocytes were studied. Antitumor activity of cells increased, but their natural suppressor activity decreased in the presence of dexamethasone. Pretreatment with dexamethasone (for 3 h) did not affect the sensitivity of mastocytoma cells to antitumor factors and the antitumor activity of bone marrow effectors. Pretreatment of bone marrow cells with dexamethasone for 24 h potentiated antitumor activity of their nonadherent fractions.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: N V
authors.initials: NV
authors.lastname: Bel'skaya
authors.forename: E S
authors.initials: ES
authors.lastname: Stal'bovskaya
authors.forename: Y P
authors.initials: YP
authors.lastname: Bel'skii
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000276:immunology / Q000473:pathology*; D018920:Coculture Techniques; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D012515:Mast-Cell Sarcoma / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D018931:Antineoplastic Agents, Hormonal; D003907:Dexamethasone