Diversity and prevalence of PorA types in Neisseria meningitidis serogroup B in the United States, 1992-1998.
Two hundred eighty-one sporadic Neisseria meningitidis serogroup B isolates, collected through active laboratory-based surveillance, were selected to be analyzed by PorA variable region (VR) typing to determine the prevalence of PorA types in the United States. A substantial number of distinct VR types were identified, 31 in VR1 and 41 in VR2. A total of 73 different PorA types were found, and 76. 7% of these types comprise nonprototype sequences in VR1, VR2, or both. The most prevalent PorA types were P1.7,16-20 (previously P1.7, 16i), P1.22,14, P1.22-1,14 (previously P1.22a,14), P1.7,16, P1.7-1,1 (previously P1.7d,1), P1.19,15, and P1.17,16-3 (previously P1.B,16d). No correlation was observed between the PorA types and geographic origin of the isolates. These data may aid in the design of an efficacious outer membrane protein-based vaccine by identifying the most appropriate PorA types for vaccine formulation. Studies are needed to fully evaluate the extent of cross-protection in humans among the variants and prototypes in each PorA VR family.
Sacchi
C T
CT
Meningitis and Special Pathogens Branch, Mail Stop D-11, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. cls9@cdc.gov
Whitney
A M
AM
Popovic
T
T
Beall
D S
DS
Reeves
M W
MW
Plikaytis
B D
BD
Rosenstein
N E
NE
Perkins
B A
BA
Tondella
M L
ML
Mayer
L W
LW
D002487:Centers for Disease Control and Prevention, U.S.; D014644:Genetic Variation; D006801:Humans; D008585:Meningitis, Meningococcal / Q000453:epidemiology / Q000382:microbiology*; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D011159:Population Surveillance; D018272:Porins / Q000235:genetics*; D014481:United States / Q000453:epidemiology
D018272:Porins