title: Cortisol concentrations following stimulation of healthy and adrenopathic dogs with two doses of tetracosactrin.
abstract: A prospective study was undertaken to compare intravenous tetracosactrin at doses of 5 microg/kg and 250 microg for diagnosing hyperadrenocorticism in dogs. Both healthy dogs and dogs with pituitary-dependent hyperadrenocorticism were evaluated with the two doses of the drug, and serum cortisol concentrations were compared at 60 minutes post-stimulation. Some of the dogs had additional samples taken at 90 and 120 minutes. For four dogs with hyperadrenocorticism, timed samples were also obtained at 150, 180 and 240 minutes post-injection. Cortisol concentrations 60 minutes after stimulation with either 5 microg/kg or 250 microg intravenous tetracosactrin were similar for both healthy dogs and dogs with hyperadrenocorticism. The lower dose can therefore be used for diagnosing hyperadrenocorticism in dogs.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Tennessee, College of Veterinary Medicine, Knoxville, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Frank
authors.forename: R C
authors.initials: RC
authors.lastname: DeNovo
authors.forename: A C
authors.initials: AC
authors.lastname: Kraje
authors.forename: J W
authors.initials: JW
authors.lastname: Oliver
mesh_terms: D000308:Adrenocortical Hyperfunction / Q000175:diagnosis / Q000662:veterinary*; D000818:Animals; D003366:Cosyntropin / Q000493:pharmacokinetics; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000097:blood*; D007275:Injections, Intravenous; D011446:Prospective Studies; D011897:Random Allocation; D012016:Reference Values; D013997:Time Factors
chemical_list: D003366:Cosyntropin; D006854:Hydrocortisone