Highly active antiretroviral therapy (HAART) and circulating markers of immune activation: specific effect of HAART on neopterin.
The circulating levels of immune activation markers, including neopterin, tumor necrosis factor receptor type II, and interleukin-2 receptors, are increased in human immunodeficiency virus-infected patients. We show here that highly active antiretroviral therapy significantly decreased neopterin levels. This effect is reversible, since neopterin levels increased after the arrest of treatment. Their determination may be useful in the evaluation of the efficacy of antiretroviral therapy.
Amirayan-Chevillard
N
N
Faculté de Médecine, Unité des Rickettsies, Université de la Méditerranée, CNRS UPRESA 6020, 13385 Marseille Cedex 5, France.
Tissot-Dupont
H
H
Obadia
Y
Y
Gallais
H
H
Mege
J L
JL
Capo
C
C
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood*; D011933:Reagent Kits, Diagnostic; D017455:Receptors, IgE / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000097:blood; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D047889:Receptors, Tumor Necrosis Factor, Type II; D012680:Sensitivity and Specificity
D019380:Anti-HIV Agents; D015703:Antigens, CD; D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; D017455:Receptors, IgE; D015375:Receptors, Interleukin-2; D018124:Receptors, Tumor Necrosis Factor; D047889:Receptors, Tumor Necrosis Factor, Type II; D019798:Neopterin