title: Criteria predictive of limb viability at 1 year in patients with chronic severe ischemia--TcPO2 and demographic parameters.
abstract: Following an earlier study, the investigators sought to identify and define objective prognostic criteria of viability at 1 year of a limb with severe chronic ischemia. A study was undertaken in 116 patients (118 limbs) (74 men and 42 women), with a mean age of 71.9 years for men and 81.6 years for women. Static transcutaneous oxygen pressure (TcPO2) was measured with a verticalization sensitization test and inhalation of oxygen on JO and viability of the limb noted 1 year later. Logistic analysis was made of 13 oximetry parameters and two demographic parameters (age and gender). Results were analyzed in absolute terms and by tissue oxygenation ratio (TOR) (ratio between absolute TcPO2 at the foot and at a chest reference electrode). Six factors appeared to be prognostic factors of limb viability at 1 year, statistically significant at 6% according to threshold values: age, verticalization TcPO2, TcPO2 after 1 minute's inhalation of oxygen, TcPO2 after 4 minutes' inhalation of oxygen, and slope of TcPO2 and slope of TOR between 1 and 4 minutes' inhalation. A 1 year viability index integrating these criteria is suggested.
authors.affiliation: Centre La Fontaine au Bac, Groupe d'Etude Mayennais des Affections Vasculaires, Le Bignon du Maine, France.
authors.forename: D
authors.initials: D
authors.lastname: Chomard
authors.forename: P
authors.initials: P
authors.lastname: Habault
authors.forename: D
authors.initials: D
authors.lastname: Eveno
authors.forename: S
authors.initials: S
authors.lastname: Le Lamer
authors.forename: M
authors.initials: M
authors.lastname: Ledemeney
authors.forename: C
authors.initials: C
authors.lastname: Haon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001785:Blood Gas Monitoring, Transcutaneous; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D007866:Leg / Q000098:blood supply*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D014022:Tissue Survival / Q000502:physiology