title: Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis.
abstract: Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toxoid could protect against corneal damage. Results show that either form of immunization did not kill bacteria but did significantly protect against corneal pathology, especially epithelial erosion.
authors.affiliation: Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
authors.forename: E B
authors.initials: EB
authors.lastname: Hume
authors.forename: J J
authors.initials: JJ
authors.lastname: Dajcs
authors.forename: J M
authors.initials: JM
authors.lastname: Moreau
authors.forename: R J
authors.initials: RJ
authors.lastname: O'Callaghan
mesh_terms: D000818:Animals; D003315:Cornea / Q000382:microbiology / Q000473:pathology*; D015818:Eye Infections, Bacterial / Q000276:immunology / Q000473:pathology; D007114:Immunization; D007634:Keratitis / Q000382:microbiology / Q000473:pathology*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000276:immunology* / Q000378:metabolism; D014121:Toxoids / Q000276:immunology*; D010738:Type C Phospholipases / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D014121:Toxoids; D010738:Type C Phospholipases