title: Towards enzyme activated antiprostatic agents.
abstract: A prodrug conjugate designed to undergo activation by enzymatic prostate specific antigen has been synthesized. The prodrug system undergoes activation with PSA or alpha-chymotrypsin, and shows selective cytotoxicity in a PSA secreting cell line.
authors.affiliation: Department of Chemistry, Northeastern University, Boston, MA 02115, USA. grjones@lynx.neu.edu
authors.forename: G B
authors.initials: GB
authors.lastname: Jones
authors.forename: M O
authors.initials: MO
authors.lastname: Mitchell
authors.forename: J S
authors.initials: JS
authors.lastname: Weinberg
authors.forename: A V
authors.initials: AV
authors.lastname: D'Amico
authors.forename: G J
authors.initials: GJ
authors.lastname: Bubley
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008297:Male; D011355:Prodrugs / Q000138:chemical synthesis*; D017430:Prostate-Specific Antigen / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D011355:Prodrugs; D017430:Prostate-Specific Antigen