title: Fibromyalgia, hypermobility, and breast implants.
abstract: OBJECTIVE
  To examine possible relationships among fibromyalgia (FM, American College of Rheumatology 1990 criteria), hypermobility, and breast implants.
  
  
  METHODS
  The medical records of 2,500 female patients (ages 25-65) who had been seen for the first time in a rheumatology practice in Atlanta, GA, during 1986-92 were abstracted and analyzed. In each analysis, patients whose records indicated that the patient met the full case criteria were compared with patients whose records had no indication of the disease. Patients whose medical records indicated the clinical onset of FM prior to breast implantation were identified.
  
  
  RESULTS
  Univariate and multivariate regression analyses were performed, adjusting for age, income, and the presence of connective tissue disease or rheumatoid arthritis. Significant associations were found between hypermobility and FM (adjusted OR 2.20, 95% CI 1.73, 2.80) and between hypermobility and breast implantation (adjusted OR 1.80, 95% CI 1.19, 2.69). No association was found between breast implantation and subsequent FM (adjusted OR 0.74, 95% CI 0.42, 1.32).
  
  
  CONCLUSIONS
  Hypermobility was found to be independently associated with both FM and with breast implantation, but FM and breast implantation were not found to be independently associated with each other.
authors.affiliation: Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lai
authors.forename: J A
authors.initials: JA
authors.lastname: Goldman
authors.forename: A H
authors.initials: AH
authors.lastname: Child
authors.forename: A
authors.initials: A
authors.lastname: Engel
authors.forename: S H
authors.initials: SH
authors.lastname: Lamm
mesh_terms: D000328:Adult; D000368:Aged; D018427:Breast Implants / Q000009:adverse effects*; D005260:Female; D005356:Fibromyalgia / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007593:Joint Instability / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D012307:Risk Factors