Neurobiology. Turning attraction into repulsion.
A series of molecular cues guide axons as they extend in the embryonic environment. In her Perspective, Pasquale discusses new findings that reveal how signals originating from adhesive contacts between axons and the cells they encounter can repel the axon, causing it to break the adhesive contacts and move away (Hattori et al. and Galko and Tessier-Lavigne).
Pasquale
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Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. elenap@burnham.org
D000818:Animals; D001369:Axons / Q000502:physiology*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D000075389:DCC Receptor; D019483:Disintegrins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D029721:Drosophila Proteins; D036383:Ephrin-A2; D017261:Glycosylphosphatidylinositols / Q000378:metabolism; D020439:Growth Cones / Q000502:physiology; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051379:Mice; D009414:Nerve Growth Factors / Q000378:metabolism*; D000075386:Netrin Receptors; D000075388:Netrin-1; D011480:Protease Inhibitors / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins
D015815:Cell Adhesion Molecules; D000075389:DCC Receptor; C501910:Dcc protein, mouse; D019483:Disintegrins; D029721:Drosophila Proteins; D036383:Ephrin-A2; D017261:Glycosylphosphatidylinositols; D008024:Ligands; D008565:Membrane Proteins; D009414:Nerve Growth Factors; D000075386:Netrin Receptors; D011480:Protease Inhibitors; D011956:Receptors, Cell Surface; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1; C100953:KUZ protein, Drosophila; D008666:Metalloendopeptidases