[A trial of the preparation Cheblin-SK-1 in models of nematodiases].
A kerosene milky-stage walnut (Juglans spp.) extract, a folk medication, has come into wide use in the past 30 years. The drug CK-I was prepared on a scientific basis. Its acute toxicity and toxicological profile were studied on albino mice and rats, chickens, chicken embryos, piglets. The maximum non-lethal dose of CK-I was 19 g/kg for albino mice and 21 g/kg for albino rats. The drug can be classified as i.v. hazard class. The anthelmintic effects of CK-I were examined in mice with cyphaciasis and in chickens with ascariasis and heterakiasis. In murine cyphaciasis, CK-I given in a dose of 75 mg/kg to albino mice provided 100% efficiency. Its doses of 800 and 1000 mg/kg were required to achieve this effect in chick ascariasis and heterakiasis, respectively.
Samylina
I A
IA
Streliaeva
A V
AV
Chebyshev
N V
NV
Sadykov
V M
VM
D000818:Animals; D021461:Animals, Outbred Strains; D000969:Antinematodal Agents / Q000627:therapeutic use* / Q000633:toxicity; D002645:Chickens; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D007648:Kerosene / Q000633:toxicity; D008297:Male; D051379:Mice; D009349:Nematode Infections / Q000188:drug therapy*; D009754:Nuts / Q000627:therapeutic use* / Q000633:toxicity; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use / Q000633:toxicity; D011201:Poultry Diseases / Q000188:drug therapy; D051381:Rats; D012997:Solvents / Q000633:toxicity
D000969:Antinematodal Agents; D007648:Kerosene; D010936:Plant Extracts; D012997:Solvents