[The vasomotor effects of new fluorine-containing synthetic activators of ATP-dependent potassium channels].
The influence of new fluorine-containing activators of K+ channels on the vascular tone was investigated in vitro experiments on the guinea pig aorta. We exerted the identification of mechanisms of the action of these substances using the well-known ATP-sensitive K+ channel inhibitor--glibenclamid--and showed their dose-effect correlation. It was shown that new fluorine-containing activators of K+ channels--PF-5 and PF-10--are powerful vasodilator substances and PF-5 in concentration more than 0.1 mM exerts a distort of vascular reaction on the vasoconstriction.
Strutyns'kyĭ
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A. A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Moĭbenko
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Iahupol's'kyĭ
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LM
D000255:Adenosine Triphosphate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005905:Glyburide / Q000494:pharmacology; D006168:Guinea Pigs; D007004:Hypoglycemic Agents / Q000494:pharmacology; D066298:In Vitro Techniques; D020110:Pinacidil / Q000031:analogs & derivatives* / Q000494:pharmacology*; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000819:agonists* / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*; D014666:Vasomotor System / Q000187:drug effects*
D007004:Hypoglycemic Agents; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D014665:Vasodilator Agents; D020110:Pinacidil; D000255:Adenosine Triphosphate; D005905:Glyburide