title: Natural killer cells determine the outcome of B cell-mediated autoimmunity.
abstract: Natural killer (NK) cells can affect the outcome of adaptive immune responses. NK cells, but not NK1.1+T cells, were found to participate in the development of myasthenia gravis (a T cell-dependent, B cell- and antibody-mediated autoimmune disease) in C57BL/6 mice. The requirement for NK cells was reflected by the lack of a type I helper T cell response and antibodies to the acetylcholine receptor in both NK1.1+ cell-depleted and NK cell-deficient IL-18-/- mice. These findings establish a previously unrecognized link between NK cells and autoreactive T and B cells.
authors.affiliation: Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden.
authors.forename: F D
authors.initials: FD
authors.lastname: Shi
authors.forename: H B
authors.initials: HB
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Hong
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Link
authors.forename: L
authors.initials: L
authors.lastname: Van Kaer
authors.forename: H G
authors.initials: HG
authors.lastname: Ljunggren
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D007114:Immunization; D007178:Inbreeding; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D016209:Interleukin-8 / Q000235:genetics / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D020720:Myasthenia Gravis, Autoimmune, Experimental / Q000276:immunology; D011978:Receptors, Nicotinic / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014101:Torpedo; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000276:immunology
chemical_list: D001323:Autoantibodies; D016209:Interleukin-8; D011978:Receptors, Nicotinic; D016212:Transforming Growth Factor beta; D007371:Interferon-gamma