Healing of bronchial allografts in pigs.
Our purpose was to investigate the healing of bronchial grafts in a porcine experimental model. Via left thoracotomy, a 2.5 cm long bronchial stump was anastomosed back to the same animal (autograft) or to another pig (allograft). Autotransplanted bronchi (six pigs) healed very well without infection. Allotransplantation without immunosuppression (eight pigs) was followed in all cases by rejection with formation of major bronchopleural fistula. After allotransplantation with triple-drug immunosuppressive medication (seven pigs), three pigs showed infection-free healing, but the anastomoses were slightly stenosed at the time of sacrifice (mean 30 d), while four had bronchopleural fistula. The study thus showed the healing ability of totally avascular bronchial graft in pigs to be very good when it is autotransplanted, but poor when allotransplanted without immunosuppressive treatment.
Korpela
A
A
Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Finland.
Aarnio
P
P
Taskinen
E
E
Ikonen
T
T
Harjula
A
A
D000818:Animals; D001707:Biopsy, Needle; D001980:Bronchi / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology* / Q000637:transplantation*; D004195:Disease Models, Animal; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000517:prevention & control; D006085:Graft Survival; D007166:Immunosuppressive Agents / Q000494:pharmacology; D016040:Lung Transplantation; D008297:Male; D012016:Reference Values; D015996:Survival Rate; D013552:Swine; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D007166:Immunosuppressive Agents