title: Gynecological factors and body mass index as determinants of bone mass in normal postmenopausal women. A study with peripheral quantitative computed tomography (pQCT).
abstract: OBJECTIVE
  This paper studied the influence of several gynecological factors (years since menopause (YSM), age at menarche and gynecological age or reproductive life) simultaneously with anthropometric factors as determinants of bone mass in 189 healthy postmenopausal women.
  
  
  METHODS
  Bone mass was determined by peripheral quantitative computed tomography.
  
  
  RESULTS
  An overall evaluation showed that YSM correlated negatively with trabecular and cortical bone density (BMDTrab and BMDCorti) (P<0.05 in both cases). Age at menarche correlated negatively with BMDCorti (P<0.05) and gynecological age correlated positively with BMDTrab (P<0.05). Classifying the women according to their body mass index (BMI), the YSM correlation persisted in those subjects whose BMI was >25 kg/m(2), and in age at menarche and gynecological age of women whose BMI was <25 kg/m(2) (P<0.05). After separating women according to their age at menarche, their gynecological age and BMI, the only significant difference that persisted was in BMDTrab which was lower in the group with gynecological age <33 years, with a BMI <25 kg/m(2) (P=0.020). Parity and smoking had no impact on our results. By multiple regression, with BMD as the dependent variable and the gynecological factors as independent variables, we only observed significance between YSM and BMDCorti (P<0.005). The same was observed after separating women according to their BMI in the >25 kg/m(2) group (P<0.05).
  
  
  CONCLUSIONS
  Our data stress the importance of YSM on BMDTrab and BMDCorti, of age at menarche on BMDCorti and of gynecological age on BMDTrab. However, YSM is the gynecological factor that mainly determines BMD. The differences observed between measurements taken with pQCT and other methods commonly used to estimate bone mass indicate that results obtained with one technique cannot be extrapolated to other methods.
authors.affiliation: Department of Medicine, University of Alcalá, 28801, Madrid, Spain.
authors.forename: E R
authors.initials: ER
authors.lastname: Hernández
authors.forename: C
authors.initials: C
authors.lastname: Seco
authors.forename: J
authors.initials: J
authors.lastname: Cortés-Prieto
authors.forename: L F
authors.initials: LF
authors.lastname: Villa
authors.forename: M
authors.initials: M
authors.lastname: Revilla
authors.forename: H
authors.initials: H
authors.lastname: Rico
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D015519:Bone Density; D005260:Female; D006801:Humans; D008572:Menarche; D008875:Middle Aged; D017698:Postmenopause; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed