title: [Diagnosis and treatment of sensorineural hearing deficits of autoimmune origin].
abstract: Sensorineural hearing loss (SHL) of autoimmune origin is characterized by a rapidly progressive onset. Diagnosis is difficult and the condition responds to corticoids or immunosuppressant agents. Two cases with an onset over weeks and progressive hearing loss are reported. Both patients had SHL associated with another autoimmune disease. Laboratory findings were abnormal (immunoglobulins and lymphocyte populations), suggesting an immune disorder. Treatment with 1 mg/kg/day of deflazacort restored hearing to normal. Both patients are currently asymptomatic. The clinical and laboratory response of patients to deflazacort supported the diagnosis of autoimmune SHL.
authors.affiliation: Servicio de ORL, Hospital La Inmaculada, Huércal-Overa, Almería.
authors.forename: J L
authors.initials: JL
authors.lastname: Castillo
authors.forename: J A
authors.initials: JA
authors.lastname: López-Escámez
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001327:Autoimmune Diseases / Q000150:complications*; D018450:Disease Progression; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D011282:Pregnenediones / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D000893:Anti-Inflammatory Agents; D011282:Pregnenediones; C021988:deflazacort