[Diphenylhydantoin-induced pure red cell aplasia after neurological surgery: report of two cases].
Pure red cell aplasia (PRCA) is characterized by severe anemia, reticulocytopenia, marked selective hypoplasia of the erythroid precursor cells in the bone marrow and normal peripheral leukocyte and platelet counts. We reported two cases of diphenylhydantoin (DPH)-induced PRCA after neurological surgery. They recovered completely with discontinuance of DPH therapy. Neurosurgeons should be aware of this side effect because most reported cases of PRCA have occurred about a few months after neurological surgery under general anaesthesia and DPH therapy.
Tanaka
S
S
Tanaka Neurosurgical Clinic, Kagoshima-shi, Japan.
Toujou
H
H
Tara
M
M
Uetsuhara
K
K
D000368:Aged; D000768:Anesthesia, General; D000777:Anesthetics / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects*; D001803:Blood Transfusion; D005260:Female; D006801:Humans; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010672:Phenytoin / Q000009:adverse effects*; D011182:Postoperative Care; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced* / Q000628:therapy; D016896:Treatment Outcome
D000777:Anesthetics; D000927:Anticonvulsants; D010672:Phenytoin