The 10 kDa protein of Taenia solium metacestodes shows genus specific antigenicity.
Genus specific antigenicity of the 10 kDa protein in cyst fluid (CF) of Taenia solium metacestodes was demonstrated by comparative immunoblot analysis. When CFs from taeniid metacestodes of T. saginata, T. solium, T. taeniaeformis and T. crassiceps were probed with specific monoclonal antibody (mAb) raised against 150 kDa protein of T. solium metacestodes, specific antibody reactions were observed in 7 and 10 kDa proteins of T. solium and in 7/8 kDa of T. saginata, T. taeniaeformis and T. crassiceps. The mAb did not react with any protein in hydatid fluid of Echinococcus granulosus and E. multilocularis. This result revealed that the 10 kDa peptide of T. solium metacestodes and its equivalent proteins of different Taenia metacestodes are genus specific antigens that are shared among different Taenia species.
Park
S K
SK
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
Yun
D H
DH
Chung
J Y
JY
Kong
Y
Y
Cho
S Y
SY
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000947:Antigens, Helminth / Q000276:immunology*; D000939:Epitopes; D015801:Helminth Proteins / Q000276:immunology*; D006801:Humans; D008970:Molecular Weight; D020019:Neurocysticercosis / Q000175:diagnosis; D013045:Species Specificity; D013621:Taenia / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000947:Antigens, Helminth; D000939:Epitopes; D015801:Helminth Proteins