Proportional criterion of metabolic activity and fundamentals of drug dosage.
A method for determining the drug dose is proposed, according to which the dose of injected drug is proportional to body weight to the power 2/3. The dosage of narcotic analgesic ketamine is in good agreement with the proposed relationship.
Turkovskii
I I
II
Military Medical Academy, St. Petersburg.
Kuznetsov
A N
AN
D000818:Animals; D001835:Body Weight; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D008660:Metabolism; D011817:Rabbits; D051381:Rats