The chirality of the cholesteric phases of DNA and G-wires: its connection to their molecular structures.
While the handedness of the cholesteric phases formed by assembled guanosine derivatives (G-wires) follow the correlation right-handed helices-->right-handed cholesterics (left-handed -->left-handed), the cholesteric phase formed by B-DNA (right-handed helix) is left-handed. This apparent discrepancy is overcome by considering pitch (p) variations with temperature. Plots of p(-1) versus T(-1) have, in fact, the same trend (positive intercept and negative slope) in the case of right-handed G-wires and B-DNA, while for the left-handed G-wire of deoxyguanosine monophosphate (dGMP), the opposite behavior is observed (negative intercept and positive slope). Therefore, the relation between molecular handedness and cholesteric helicity cannot, in general, be assessed by using measurements based on a single temperature; hence the temperature variation of the cholesteric parameters should be investigated. In all cases there is no remarkable salt effect on the cholesteric parameters.
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Dipartimento di Chimica Organica A. Mangini, Università di Bologna, Italy.
Gottarelli
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Mariani
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Spada
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D000818:Animals; D001483:Base Sequence; D002417:Cattle; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D006151:Guanosine / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D013237:Stereoisomerism
D006151:Guanosine; D004247:DNA