title: Sleep, memory maintenance, and mental disorders.
abstract: Memory circuits of the brain are activated by self-generated brain waves, primarily during sleep. These activations refresh the efficacies (strengths) of synapses in affected circuits, maintaining the efficacies at the "dedicated" values that support circuit functions. The neural pathologies underlying many mental disorders appear to exert their deleterious influences by inducing abnormalities in brain waves. The abnormal waves, in turn, fail to sustain dedicated synaptic efficacies in memory circuits, leading to mental malfunction. Dreaming is an "unconscious" awareness of circuit reinforcement during sleep, with dream contents being derived from the activated circuits. When synaptic efficacies are degraded, the dreams are illusory.
authors.affiliation: Department of Organismic Biology, Ecology and Evolution, University of California, Los Angeles 90095-1606, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Kavanau
mesh_terms: D006801:Humans; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D001523:Mental Disorders / Q000188:drug therapy / Q000523:psychology*; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use; D012890:Sleep / Q000187:drug effects / Q000502:physiology*
chemical_list: D011619:Psychotropic Drugs