Studies of the cardiovascular effects of nociceptin and related peptides.
Nociceptin, a novel opioid peptide, and its ORL(1) receptor share structural similarities with other opioid ligands and receptors. Although NC exerts evident cardiovascular effects at a central and peripheral level, its role in homeostatic mechanisms and disease states are just beginning to be understood, as only recently selective receptor antagonists became available. In this review, some of the new observations regarding the cardiovascular actions of NC, related peptides and newly synthesized receptor antagonists are discussed.
Salis
M B
MB
National Laboratory of the National Institute of Biostructures and Biosystems, Osilo, Italy.
Emanueli
C
C
Milia
A F
AF
Guerrini
R
R
Madeddu
P
P
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008024:Ligands; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D018847:Opioid Peptides / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology / Q000502:physiology; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology; D000097629:Nociceptin
D007473:Ion Channels; D008024:Ligands; D018847:Opioid Peptides; D010455:Peptides; D014665:Vasodilator Agents; D000097629:Nociceptin