Patterning of sympathetic nerve activity in response to vestibular stimulation.
Growing evidence suggests a role for the vestibular system in regulation of autonomic outflow during postural adjustments. In the present paper we review evidence for the patterning of sympathetic nerve activity elicited by vestibular stimulation. In response to electrical activation of vestibular afferents, firing of sympathetic nerves located throughout the body is altered. However, activity of the renal nerve is most sensitive to vestibular inputs. In contrast, high-intensity simultaneous activation of cutaneous and muscle inputs elicits equivalent changes in firing of the renal, superior mesenteric and lumbar colonic nerves. Responses of muscle vasoconstrictor (MVC) efferents to vestibular stimulation are either inhibitory (Type I) or are comprised of a combination of excitation and inhibition (Type II). Interestingly, single MVC units located in the hindlimb exhibited predominantly Type I responses while those located in the forelimb and face exhibited Type II responses. Furthermore, brachial and femoral arterial blood flows were dissociated in response to vestibular stimulation, such that brachial vascular resistance increased while femoral resistance decreased. These studies demonstrate that vestibulosympathetic reflexes are patterned according to both the anatomical location and innervation target of a particular sympathetic nerve, and can lead to distinct changes in local blood flow.
Kerman
I A
IA
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA. Kerman@neurosci.bns.pitt.edu
McAllen
R M
RM
Yates
B J
BJ
D000818:Animals; D004558:Electric Stimulation; D006801:Humans; D018482:Muscle, Skeletal / Q000294:innervation; D011187:Posture / Q000502:physiology*; D012018:Reflex / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D013564:Sympathetic Nervous System / Q000166:cytology / Q000502:physiology*; D014725:Vestibular Nerve / Q000166:cytology / Q000502:physiology*; D014722:Vestibule, Labyrinth / Q000166:cytology / Q000502:physiology*; D014781:Viscera / Q000294:innervation