title: Transformation of jervine by Cunninghamella elegans ATCC 9245.
abstract: Preparative-scale fermentation of the known C-nor-D-homosteroidal jerveratrum alkaloid jervine with Cunninghamella elegans (ATCC 9245) has resulted in the isolation of (-)-jervinone as the major metabolite. In addition, C. elegans ATCC 9245 was able to epimerize C-3 of jervine, producing 3-epi-jervine. This epimerization reaction was similar to that reported for tomatidine, the known spirosolane-type Solanum alkaloid. The structure elucidation of both metabolites was based primarily on 1D- and 2D-NMR analyses.
authors.affiliation: Faculty of Pharmacy, Pharmacognosy Department, Mansoura University, Egypt. elsayed99@yahoo.com
authors.forename: K A
authors.initials: KA
authors.lastname: El Sayed
authors.forename: A F
authors.initials: AF
authors.lastname: Halim
authors.forename: A M
authors.initials: AM
authors.lastname: Zaghloul
authors.forename: D C
authors.initials: DC
authors.lastname: Dunbar
authors.forename: J D
authors.initials: JD
authors.lastname: McChesney
mesh_terms: D005285:Fermentation; D009090:Mucorales / Q000378:metabolism*; D013057:Spectrum Analysis; D014704:Veratrum Alkaloids / Q000378:metabolism*
chemical_list: D014704:Veratrum Alkaloids; C010206:jervine