Altered gene expression upon BCR cross-linking in Burkitt's lymphoma B cell line.
Burkitt's lymphoma cell line, BL2 was stimulated by surface BCR cross-linking and altered gene expression was analyzed by RDA methodology. Consistent with previous reports, we detected up-regulated MDC, IL6R and adhesion molecule LFA1. We also detected gene expression of SIRPalpha, anti-apoptotic A-20, signal regulatory SLP76 and BCAR3, DNA binding proteins EGR2 and DEC1 in addition to some new genes.
Nakayama
Y
Y
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA. yasuhiro.nakayama@yale.edu
Iwamoto
Y
Y
Maher
S E
SE
Tanaka
Y
Y
Bothwell
A L
AL
D000906:Antibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation; D003001:Cloning, Molecular; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D011940:Receptor Aggregation; D015398:Signal Transduction; D014407:Tumor Cells, Cultured
D000906:Antibodies; D007075:Immunoglobulin M; D009363:Neoplasm Proteins; D012333:RNA, Messenger