[Occupational exposure to organic solvents and pregnancy. Review of current epidemiologic knowledge].
The findings and methodological issues of recent epidemiological studies (1989-1999) on adverse developmental effects of maternal occupational exposure to organic solvents are reviewed. Several studies suggest the possibility of a moderate increase in the risk of spontaneous abortion and congenital malformations, especially facial clefts, associated with maternal exposure to solvents. A common methodological weakness of these studies is the inaccuracy of data on exposures. Positive findings encourage further epidemiological studies of high-quality design and use of protective measures to minimize exposure to these agents from the preconceptional period to the end of pregnancy.
Saillenfait
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Institut National de Recherche et de Sécurité, Avenue de Bourgogne, BP n degrees 27, 54501 Vandoeuvre Cedex.
Robert
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D000014:Abnormalities, Drug-Induced / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D000022:Abortion, Spontaneous / Q000139:chemically induced* / Q000453:epidemiology* / Q000517:prevention & control; D004784:Environmental Monitoring; D015340:Epidemiologic Research Design; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D007219:Industrial Oils / Q000009:adverse effects* / Q000032:analysis*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis* / Q000517:prevention & control; D016272:Occupational Health; D011247:Pregnancy / Q000187:drug effects*; D012307:Risk Factors; D012997:Solvents / Q000009:adverse effects* / Q000032:analysis*
D012997:Solvents