title: Effect and time course of deep brain stimulation of the globus pallidus and subthalamus on motor features of Parkinson's disease.
abstract: We studied the effect and temporal profile of deep brain stimulation (DBS) of the globus pallidus and subthalamic nucleus on the motor signs of Parkinson's disease (PD). Four patients with bilateral deep brain stimulators of the globus pallidus and four patients with bilateral deep brain stimulators of the subthalamus were studied while taking no medication and at 15 and 30 minutes and 1, 2, 4, and 6 hours after turning stimulation on. An immediate (15 minutes) and sustained (6 hours) benefit was observed for all the motor manifestations of PD for both stimulation sites. Deep brain stimulation of the globus pallidus and subthalamus is highly effective in reducing all the cardinal motor features of PD.
authors.affiliation: Department of Neurology, University of Kansas Medical Center, Kansas City, USA.
authors.forename: A
authors.initials: A
authors.lastname: Hristova
authors.forename: K
authors.initials: K
authors.lastname: Lyons
authors.forename: A I
authors.initials: AI
authors.lastname: Tröster
authors.forename: R
authors.initials: R
authors.lastname: Pahwa
authors.forename: S B
authors.initials: SB
authors.lastname: Wilkinson
authors.forename: W C
authors.initials: WC
authors.lastname: Koller
mesh_terms: D004599:Electric Stimulation Therapy; D007839:Functional Laterality / Q000502:physiology; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D011187:Posture / Q000502:physiology; D011597:Psychomotor Performance; D020530:Subthalamus / Q000503:physiopathology*; D016138:Walking