Does fucose or piracetam modify the effect of hypoxia preconditioning against pentylenetetrazol-induced seizures?
To clarify the question whether the duration of hypoxia exposure has an influence on the point in time or the strength of hypoxic preconditioning, hypoxia exposure of rats lasting 1 and 8 h was tested regarding the modification of susceptibility to acute pentylenetetrazol-induced seizures. Following the short-lasting (1 h) hypoxia, the maximum level of preconditioning action was observed 7 days after hypoxia, whereas the longer-lasting hypoxia (8 h) produced the maximum level of protection 14 days after hypoxia. We investigated the influence of fucose and piracetam on the effect of hypoxia preconditioning by the application of the substances 20 min before the beginning of hypoxia exposure. Fucose did not modify the result of hypoxia preconditioning. But after the treatment with piracetam, the preconditioning effect was prevented following hypoxia lasting 1 and 8 h. We suggest that the radical scavenger properties of piracetam are responsible for the absence of protection against pentylenetetrazol-evoked seizures.
Rauca
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C
Department of Pharmacology and Toxicology, Faculty of Medicine, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany. christine.rauca@medizin.uni-magdeburg.de
Jantze
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H
Krug
M
M
D000818:Animals; D005643:Fucose / Q000494:pharmacology*; D000860:Hypoxia; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors
D018696:Neuroprotective Agents; D005643:Fucose; D010433:Pentylenetetrazole; D010889:Piracetam