title: [Genetic characteristics of the wing mutation Odd(22) and its interaction with alleles of the Delta locus in Drosophila virilis].
abstract: The dominant sex-linked semilethal mutation Odd22 was isolated from progeny of a dysgenic cross of Drosophila virilis lines. Flies homozygous, heterozygous, and hemizygous for Odd22 displayed multiple wing defects, including enlargements and gaps on the veins; irregularly thickened, branched, shortened, or completely reduced veins; and cuts on the wing margin. The most remarkable feature of the Odd22 expression was a combination of both an increase and a reduction of the wing vein material simultaneously present in the same wing, which is commonly associated with suppression and hyperfunction, respectively, of genes of the Notch (N) signaling system. Phenotypic analysis revealed the interaction of Odd22 with alleles of the Delta (Dl) locus, which codes for the ligand of the NOTCH receptor. Based on these data, Odd22 was assumed to directly or indirectly affect the activity of the genes involved in Dl-N signaling.
authors.affiliation: Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev, Ukraine.
authors.forename: I S
authors.initials: IS
authors.lastname: Gubenko
authors.forename: E S
authors.initials: ES
authors.lastname: Zelentsova
authors.forename: I A
authors.initials: IA
authors.lastname: Kozeretskaia
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Bagin
mesh_terms: D000483:Alleles; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics*; D009154:Mutation; D010641:Phenotype; D014921:Wings, Animal / Q000033:anatomy & histology / Q000378:metabolism*
chemical_list: D018398:Homeodomain Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C064045:delta protein