Translocation of P53-regulated laminin receptors in pro-apoptotic microcircumstance of human vasculogenesis inhibition.
It is not clear what type of cells will inhibit vasculogenesis and under what circumstances. Here we examined the human spontaneous abortion villi and discovered that cells in the vasculogenesis-inhibited environment appear to be pro-apoptotic as indicated by strong staining of bak. In particular, an increasing laminin receptor (LNR) expression in cytoplasm and on apical membrane, being most likely mediated by p53 because of coexpression, was observed in the pro-apoptotic syncytiotrophoblasts. The transcriptional increase and translocation of the receptors to the cytoplasm and apical membrane may be used as a pathological marker, indicating a change of the structure and function of integrins in the non-vasculogenesis micro-environment.
Wang
L
L
State Key Lab of Biomembrane & Membrane Biotechnology, Dept. of Life Science, Tsinghua Univ., Beijing, 100084, China. wanglin@tsinghua.edu.cn
Beihua
K
K
Minxing
D
D
Youzhong
Z
Z
Shaoling
L
L
Chang
Z
Z
D000022:Abortion, Spontaneous / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology*; D003593:Cytoplasm / Q000378:metabolism; D005260:Female; D006801:Humans; D018919:Neovascularization, Physiologic; D011247:Pregnancy; D017474:Receptors, Laminin / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D017474:Receptors, Laminin; D016159:Tumor Suppressor Protein p53