title: Multiple endocrine neoplasia in a dog.
abstract: Multiple endocrine neoplasms, including an insulinoma, bilateral adrenocortical adenocarcinomas and an aortic paraganglioma, were diagnosed after euthanasia in a 12-year-old spayed female dog of mixed breed with a history of progressive anorexia, vomiting, diarrhoea, weight loss, polyuria and polydipsia, regenerative anaemia and hypoglycaemia. The clinical, gross pathological, microscopical, immunohistochemical and ultrastructural findings were consistent with the human syndrome of multiple endocrine neoplasia.
authors.affiliation: Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: M
authors.initials: M
authors.lastname: Kiupel
authors.forename: P B
authors.initials: PB
authors.lastname: Mueller
authors.forename: J
authors.initials: J
authors.lastname: Ramos Vara
authors.forename: A
authors.initials: A
authors.lastname: Irizarry
authors.forename: T L
authors.initials: TL
authors.lastname: Lin
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D000818:Animals; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry; D007328:Insulin / Q000032:analysis; D008854:Microscopy, Electron; D009377:Multiple Endocrine Neoplasia / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D010235:Paraganglioma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013004:Somatostatin / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D007328:Insulin; D009418:S100 Proteins; D016708:Synaptophysin; D013004:Somatostatin; D010751:Phosphopyruvate Hydratase