title: [The biological effects of combined exposure to low-dose irradiation and heavy metal ions].
abstract: It was shown that chronic 0.25 Gy irradiation of rats (0.01 Gy/day) at background of heavy metal penetration (Cu2+, 20 mg/l or Co2+, 5 mg/l) with drinking water had caused significant accumulation of the free-radical products proportional to exhausting antioxidant and oxidizing-reduction potential in various organs and tissues. Radiation was shown to be primary harmful factor for the brain, spleen, lungs, and blood plasma, whereas the liver and heart muscle were affected with chemicals at first. Under prolonged unfavourable influence the biochemical changes observed were sustainable and progressing that satisfied to transformation of protective-adaptive reactions into prepathology stage.
authors.affiliation: Ukrainian State Institute of Medical and Social Problems of Physical Disability, Dniepropetrovsk, Ukraine.
authors.forename: T V
authors.initials: TV
authors.lastname: Anan'eva
authors.forename: E A
authors.initials: EA
authors.lastname: Likholat
authors.forename: A I
authors.initials: AI
authors.lastname: Dvoretskiĭ
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects* / Q000528:radiation effects*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000528:radiation effects; D003035:Cobalt / Q000493:pharmacokinetics / Q000633:toxicity*; D003300:Copper / Q000493:pharmacokinetics / Q000633:toxicity*; D004307:Dose-Response Relationship, Radiation; D005609:Free Radicals / Q000378:metabolism / Q000528:radiation effects; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects / Q000528:radiation effects
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; D003035:Cobalt; D003300:Copper