The association of dietary folate, B6, and B12 with cardiovascular mortality in Spain: an ecological analysis.
OBJECTIVE
This study assessed the association of dietary folate, vitamin B6, and vitamin B12 with cardiovascular mortality.


METHODS
Poisson regression analyses assessed coronary/cerebrovascular mortality rates via nutrient data obtained from the National Nutrition Survey, which recorded 7-day food intakes from a national sample of 21,155 households.


RESULTS
In regard to coronary mortality, male and female rate ratios (highest vs lowest quintile) were 0.83 (95% confidence interval [CI] = 0.77, 0.91) and 0.95 (95% CI = 0.86, 1.05), respectively, for folate and 0.74 (95% CI = 0.65, 0.84) and 0.86 (95% CI = 0.73, 0.99), respectively, for B12. Intake of folate and B6 (but not B12) was significantly associated with cerebrovascular mortality.


CONCLUSIONS
B vitamins are associated with cardiovascular mortality in the general population.
Medrano
M J
MJ
National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain. pmedrano@isciii.es
Sierra
M J
MJ
Almazán
J
J
Olalla
M T
MT
López-Abente
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000401:mortality*; D005260:Female; D005494:Folic Acid Deficiency / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys; D016012:Poisson Distribution; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D014806:Vitamin B 12 Deficiency / Q000150:complications*; D026681:Vitamin B 6 Deficiency / Q000150:complications*