Honulactones: new bishomoscalarane sesterterpenes from the Indonesian sponge Strepsichordaia aliena.
From the dichloromethane/2-propanol (1:1) extract of the Indonesian marine sponge Strepsichordaia aliena, twelve new 20, 24-bishomoscalarane sesterterpenes, honulactones A-L (1-12) were isolated. Molecular structures were secured by spectroscopic methods, accurate mass measurements, and X-ray analysis. Honulactones A (1), B (2), C (3), and D (4) exhibit cytotoxycity against P-388, A-549, HT-29, and MEL-28 (IC(50) 1 microg/mL).
Jiménez
J I
JI
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822-2275, USA.
Yoshida
W Y
WY
Scheuer
P J
PJ
Lobkovsky
E
E
Clardy
J
J
Kelly
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D054830:Sesterterpenes; D013729:Terpenes