Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing.
Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor with anti-microbial properties found in mucosal fluids. It is expressed during cutaneous wound healing. Impaired healing states are characterized by excessive proteolysis and often bacterial infection, leading to the hypothesis that SLPI may have a role in this process. We have generated mice null for the gene encoding SLPI (Slpi), which show impaired cutaneous wound healing with increased inflammation and elastase activity. The altered inflammatory profile involves enhanced activation of local TGF-beta in Slpi-null mice. We propose that SLPI is a pivotal endogenous factor necessary for optimal wound healing.
Ashcroft
G S
GS
Oral Infection and Immunity Branch, National Institute of Dental & Craniofacial Research, Building 30, 30 Convent Drive, MSC 4352, National Institutes of Health, Bethesda, Maryland 20892, USA.
Lei
K
K
Jin
W
W
Longenecker
G
G
Kulkarni
A B
AB
Greenwell-Wild
T
T
Hale-Donze
H
H
McGrady
G
G
Song
X Y
XY
Wahl
S M
SM
D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005260:Female; D017353:Gene Deletion; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D010196:Pancreatic Elastase / Q000378:metabolism; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D053481:Secretory Leukocyte Peptidase Inhibitor; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014945:Wound Healing / Q000502:physiology*
D016207:Cytokines; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; D053481:Secretory Leukocyte Peptidase Inhibitor; C506815:Slpi protein, mouse; D016212:Transforming Growth Factor beta; D010196:Pancreatic Elastase