Kinetics of plasma platinum in a hemodialysis patient receiving repeated doses of cisplatin.
The pharmacokinetics of cisplatin were studied in a 46-year-old hemodialysis patient treated for uterine cancer with weekly cisplatin. Hemodialysis was performed immediately before, one-hour after, and two-hours after cisplatin administration for two consecutive cycles each. The concentrations of total and free platinum were measured. The decay curve of both total platinum and free platinum showed a biphasic pattern characterized by an alpha-phase and a beta-phase, the same as in non-hemodialysis patients. There were no differences between the individual cycles in the peak platinum concentration or the decay pattern. The plasma platinum concentration decreased to below detection limit 3 months after the final dose.
Hirai
K
K
Department of Obstetrics and Gynecology, Osaka City University Medical School, Abenoku, Osaka 545-8585, Japan. hiraik@med.osaka-cu.ac.jp
Ishiko
O
O
Sumi
T
T
Kanaoka
Y
Y
Ogita
S
S
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D002945:Cisplatin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D010984:Platinum / Q000097:blood* / Q000493:pharmacokinetics; D006435:Renal Dialysis; D014594:Uterine Neoplasms / Q000097:blood* / Q000188:drug therapy
D000970:Antineoplastic Agents; D010984:Platinum; D002945:Cisplatin