Effect of thymus-dependent antigen on recovery of hemo- and lymphopoiesis impaired by antineoplastic drugs.
Single injection of antineoplastic drugs cyclophosphamide and cisplatin (Platidiam) in maximum permissible doses to CBA/CaLac mice impaired morphological composition of hemopoietic and lymphoid organs (thymus and spleen). Drug-induced changes persisted for 6 months. Cyclophosphamide caused more severe disturbances in the lymphoid stem in the bone marrow, thymus, and spleen and more strongly stimulated erythropoiesis in the spleen compared to cisplatin. Immunization of mice with thymus-dependent antigen (sheep erythrocytes) after injection of cytostatics accelerated regenerative processes in hemopoietic and lymphoid organs. However, cell disorganization 3 and 6 months after immunization did not differ from that caused by antineoplastic drugs and was even more pronounced in the thymus by the 6th month of observations.
Masnaya
N V
NV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Ratner
G M
GM
D000818:Animals; D000941:Antigens / Q000276:immunology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013997:Time Factors
D000941:Antigens; D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D002945:Cisplatin