title: C-erbB-2 oncoprotein content in gastric cancer and in adjacent mucosa.
abstract: The aim of this study was to evaluate, by means of an immunoenzymatic assay, the membranous and cytosolic c-erbB-2 oncoprotein contents in primary tumors and in adjacent mucosa from gastric cancer patients. Fifty-two patients with primary gastric adenocarcinomas were enrolled in this prospective study. c-erbB-2 protein levels were significantly higher in membranous than in cytosolic samples, both in neoplastic tissues (median: 3602 vs 525 NHU/mg protein; p<0.0001) and in adjacent mucosa samples (median: 3174 vs 509 NHU/mg protein; p<0.0001). Nevertheless, there was a significant positive relation between membranous and cytosolic c-erbB-2 protein contents in both neoplastic tissue (p<0.001) and adjacent mucosa (p<0.001) samples. There was no significant difference in the membranous c-erbB-2 protein content between neoplastic tissues and adjacent mucosa samples. However, the cytosolic c-erbB-2 content was significantly higher in neoplastic tissues than in adjacent mucosa (p<0.05). Finally, the results did not show any significant correlations of these oncoprotein contents with patient characteristics, clinicopathologic parameters and overall survival of the study population.
authors.affiliation: Servicio de Cirugía General, Hospital General de Asturias, Oviedo, Spain.
authors.forename: I
authors.initials: I
authors.lastname: García
authors.forename: F
authors.initials: F
authors.lastname: Vizoso
authors.forename: A
authors.initials: A
authors.lastname: Andicoechea
authors.forename: P
authors.initials: P
authors.lastname: Fernandez
authors.forename: C
authors.initials: C
authors.lastname: Suarez
authors.forename: J L
authors.initials: JL
authors.lastname: García-Muñz
authors.forename: M T
authors.initials: MT
authors.lastname: Allende
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases