title: Seroprevalence of hepatitis A virus and varicella zoster antibodies in a Javanese community (Yogyakarta, Indonesia).
abstract: Hepatitis A virus (HAV) cause an acute inflammation of the liver. Varicella-zoster virus (VZV) cause chickenpox (varicella) and herpes zoster. Effective vaccines against hepatitis A and varicella are available for children, adolescents and adults. In order to implement an appropriate vaccination policy, a baseline to assess the potential benefits and sections of the population who would benefit most are required. We investigated seroprevalence of hepatitis A virus and varicella zoster antibodies in a Javanese community. A total of 1,103 subjects were studied. The 600 subjects aged 4 to 9 years were sampled between 23 October and 2 November, 1995. The other subjects were sampled between 12 October and 1 November, 1996. The overall prevalence of anti-HAV in cohort was 28.7%. Anti-HAV seroprevalence rates were below 30% until the age of 15 and below 40% until the age of 25. The anti-varicella seroprevalence showed only in two thirds of seropositive population at the age of 15. The results of the study have implications for vaccination strategies for both hepatitis A and varicella zoster.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Dr Sardjito Hospital, Gadjah Mada University, Yogyakarta, Indonesia.
authors.forename: M
authors.initials: M
authors.lastname: Juffrie
authors.forename: R R
authors.initials: RR
authors.lastname: Graham
authors.forename: R I
authors.initials: RI
authors.lastname: Tan
authors.forename: S
authors.initials: S
authors.lastname: Widjaja
authors.forename: S
authors.initials: S
authors.lastname: Mulyadi
authors.forename: J
authors.initials: J
authors.lastname: Weil
authors.forename: H L
authors.initials: HL
authors.lastname: Bock
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002644:Chickenpox / Q000453:epidemiology / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology / Q000276:immunology*; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000097:blood*; D006507:Hepatovirus / Q000276:immunology*; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies