Lateralized P3 deficit in schizotypal personality disorder.
BACKGROUND
Reduced, left-lateralized P3 amplitude has been reported in several studies focusing on electrophysiologic function in schizophrenia. Also, several lines of evidence suggest a similarity between schizophrenia and schizotypal personality disorder (SPD). This study was undertaken to determine the replicability of our previous finding of a left-lateralized P3 amplitude deficit in SPD.


METHODS
We recorded event-related potentials in 21 SPD and 18 normal control subjects in an auditory "oddball" P3 paradigm.


RESULTS
In the SPD subjects, but not in the control subjects, there was lower P3 amplitude at T3 compared with T4.


CONCLUSIONS
These results are similar to the ones in our previous work and further support the presence of a left-lateralized P3 deficit in SPD.
Niznikiewicz
M A
MA
Harvard Medical School Department of Psychiatry, Brockton/West Roxbury VAMC, Brockton, Massachusetts 02301, USA.
Voglmaier
M M
MM
Shenton
M E
ME
Dickey
C C
CC
Seidman
L J
LJ
Teh
E
E
Van Rhoads
R
R
McCarley
R W
RW
D000328:Adult; D001143:Arousal / Q000235:genetics / Q000502:physiology*; D001288:Attention / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000235:genetics / Q000502:physiology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011930:Reaction Time / Q000235:genetics / Q000502:physiology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology