[Effect of instenon on the uterine contractile activity].
The effect of instenon upon the uterine contractile activity was studied in pregnant rats. The drug administration at a dose resulted in significant suppression of the myometrium contractility. The effect was not decreased when instenon was injected against the background of oxytocin. On the other hand, the concurrent injection of oxytocin upon a single or long-term administration of instenon produced a pronounced stimulating action on the myometrium contractility.
Korkhov
V V
VV
Laboratory of Pharmacology, Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Mengal
E V
EV
Lesik
E A
EA
Petrosian
M A
MA
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D004594:Electrophysiology; D005260:Female; D006592:Hexobendine / Q000494:pharmacology*; D009215:Myometrium / Q000187:drug effects / Q000502:physiology; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015149:Tocolytic Agents / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D001549:Benzamides; D004338:Drug Combinations; D015149:Tocolytic Agents; D010121:Oxytocin; C001453:Instenon; D006592:Hexobendine; D013806:Theophylline