[Immunopharmacologic properties of 12-iminosubstituted 8-aza-D-homogonan and trimezon].
The immunopharmacological properties of two new compounds with an 8-azasteroidal structure, representing the salts (hydrochloride and acetate) of 12-imino-substituted 8-aza-D-homogonan, were studied in comparison with the properties of the immunostimulant trimeson. Similar to trimeson, both new compounds produce a dose-dependent activation of the humoral chain of immunogenesis in the model of primary immune response to goat erythrocytes in CBA, C57BL/6, and C57W mice. The immunostimulant activity of the 8-aza-D-homogonan derivatives is inversely proportional to the antigen load (2 x 10(7)-2 x 10(9) goat erythrocytes per mice) and depends to a considerable extent of the genotype of experimental animals. A modification of the 8-aza-D-homogonan structure by substituting imino group for oxygen at position 12 of the 8-azasteroidal skeleton leads to a sharp increase in toxicity as compared to that of trimeson.
Liubin
G S
GS
Department of Biological Tests, Academy of Sciences of Belarus, Minsk, Belarus.
Konoplia
N A
NA
Guliakevich
O V
OV
Kuz'mitskiĭ
B B
BB
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001372:Aza Compounds / Q000494:pharmacology* / Q000633:toxicity; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005838:Genotype; D006041:Goats; D007928:Lethal Dose 50; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity; D013256:Steroids / Q000494:pharmacology* / Q000633:toxicity
D000276:Adjuvants, Immunologic; D001372:Aza Compounds; D013256:Steroids; C087739:trimezon