Angiocentric nasal T/natural killer cell lymphoma: a single centre study of prognostic factors in 108 patients.
Angiocentric T cell/natural killer (NK) nasal lymphoma remains a rare clinical presentation in North America and Europe but is more common in Asia and Latin America. We have reviewed 108 cases of angiocentric T/NK cell lymphoma of the nasal cavity with a view to establishing prognostic factors. Most patients were high or high intermediate clinical risk and had additional poor prognostic factors such as bulky disease, high levels of beta 2 microglobulin, advanced stage and multiple extranodal involvement. At 8 years, overall survival was 82%, 90% and 84% for low-intermediate, high-intermediate and high clinical, respectively. Disease free survival was very similar: 79%, 83% and 80%, respectively. Multivariate analysis did not identify any factor influencing overall survival and disease-free survival. There was no evidence that the international prognostic index (IPI) was applicable in these patients and it appears that angiocentric T/NK cell lymphoma is an independent prognostic factor itself.
Avilés
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Departament of Hematology, Oncology Hospital, National Medical Center, México. a.aviles@infosel.net.mx
Díaz
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Neri
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Cleto
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Talavera
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D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007694:Killer Cells, Natural; D007770:L-Lactate Dehydrogenase / Q000097:blood; D016399:Lymphoma, T-Cell / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D001613:beta 2-Microglobulin / Q000097:blood
D001613:beta 2-Microglobulin; D007770:L-Lactate Dehydrogenase