title: Ovarian transposition for patients with cervical carcinoma treated by radiosurgical combination.
abstract: OBJECTIVE
  To assess the indications, effectiveness, and complications of ovarian transposition before pelvic irradiation for cervical cancer.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Gynecologic oncology department at a French cancer center.
  
  
  METHODS
  One hundred seven patients treated for cervical cancer.
  
  
  METHODS
  Ovarian transposition to the paracolic gutters with radical hysterectomy and lymphadenectomy.
  
  
  METHODS
  Clinical and laboratory follow-up tests for ovarian function.
  
  
  RESULTS
  Bilateral ovarian transposition was achieved in 104 patients (98%). Twelve patients were lost to follow-up or excluded because of evolution of the disease. Preservation of ovarian function was achieved in 83% of the patients having follow-up. The rates of ovarian preservation were 100% for patients treated exclusively by surgery, 90% for patients treated by postoperative vaginal brachytherapy, and 60% for patients treated by postoperative external radiation therapy and vaginal brachytherapy. The main risk for ovarian failure was found in patients treated by external radiation therapy.
  
  
  CONCLUSIONS
  Ovarian transposition is a safe and effective procedure for preserving ovarian function in patients treated by a radiosurgical combination. This procedure should be performed in patients <40 years of age with a small invasive cervical carcinoma (<3 cm) treated by initial surgery. In such selected cases, the risk of ovarian metastasis is low.
authors.affiliation: Institut Gustave Roussy, Villejuif, France.
authors.forename: P
authors.initials: P
authors.lastname: Morice
authors.forename: L
authors.initials: L
authors.lastname: Juncker
authors.forename: A
authors.initials: A
authors.lastname: Rey
authors.forename: J
authors.initials: J
authors.lastname: El-Hassan
authors.forename: C
authors.initials: C
authors.lastname: Haie-Meder
authors.forename: D
authors.initials: D
authors.lastname: Castaigne
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007044:Hysterectomy; D009367:Neoplasm Staging; D010053:Ovary / Q000502:physiology / Q000601:surgery*; D011182:Postoperative Care; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy / Q000601:surgery*