title: Influence of positive end-expiratory pressure ventilation on peripheral tissue perfusion evaluated by measurements of tissue gases and pH. An experimental study in pigs with oleic acid lung injury.  .
abstract: Measurements of subcutaneous oxygen tension (PscO(2)), subcutaneous carbon dioxide tension (PscCO(2)) and subcutaneous pH (pHsc) were used for evaluation of peripheral oxygenation in pigs subjected to oleic acid-induced lung injury during ventilation with increasing levels of positive end-expiratory pressure (PEEP). Lung injury resulted in a decrease of arterial oxygen tension (PaO(2)) from 93 to 37 mm Hg (p<0.01) with maintained cardiac output. PscO(2) decreased from 45 to 17 mm Hg (p<0.01) and pHsc from 7.47 to 7.39 (p<0.05), and PscCO(2) increased from 46 to 59 mm Hg (p<0.05). Increase of PEEP level between 5 and 20 cm H(2)O resulted in a continuous increase of PaO(2) from 45 to 145 mm Hg and a decrease of cardiac output from 4.1 to 2.0 liters/min (p<0.01). PscO(2) increased up to a PEEP level of 15 cm H(2)O, reaching 26 mm Hg. Further increase of PEEP level up to 20 cm H(2)O resulted in an increase of PscCO(2) from 65 to 71 mm Hg (p<0.05) and a decrease of pHsc from 7.31 to 7.29 (p<0.05).
  
  
  CONCLUSIONS
  measurements of tissue gases and pH can be used to evaluate optimum peripheral tissue oxygenation during titration of PEEP level. Whether these measurements can be used as the only indicator to guide therapy in an individual case remains to be studied.
authors.affiliation: Department of Anaesthesiology, Malmö University Hospital, Malmö, Sweden. jedlinski@swipnet.se
authors.forename: B
authors.initials: B
authors.lastname: Jedlińska
authors.forename: A
authors.initials: A
authors.lastname: Mellström
authors.forename: K
authors.initials: K
authors.lastname: Jönsson
authors.forename: M
authors.initials: M
authors.lastname: Hartmann
mesh_terms: D000818:Animals; D001682:Biological Availability; D002245:Carbon Dioxide / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D008171:Lung Diseases / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D019301:Oleic Acid; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D010101:Oxygen Consumption; D010313:Partial Pressure; D011175:Positive-Pressure Respiration; D011669:Pulmonary Wedge Pressure; D012016:Reference Values; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply* / Q000378:metabolism*; D013552:Swine
chemical_list: D002245:Carbon Dioxide; D019301:Oleic Acid; D006859:Hydrogen; D010100:Oxygen