title: [Clinical efficacy of immunotherapy with house dust in the patients with perennial nasal allergy].
abstract: We tried to elucidate the relation of age and severity with the efficacy of immunotherapy. The subjects included 51 patients with perennial allergic rhinitis who had immunotherapy for more than a year. Symptom scores, serum total IgE levels, Dermatophagoides pteronyssinus specific IgE, and peripheral blood eosinophils counts were evaluated before, half a year, one year and two years after the onset of immunotherapy. 64% of the children's group and 69% of the adults' group of patients showed significant improvement in their nasal symptoms, showing that age is not a factor influencing the efficacy of immunotherapy. The severity of the disease influenced the clinical efficacy; the more severe the disease, the poorer the efficacy of the immunotherapy. Periphipheral blood eosinophils counts gradually decreased after the onset of immunotherapy. High eosinophil counts before immunotherapy predicted poor efficacy of the immunotherapy.
authors.affiliation: Department of Otorhinolaryngoloy, Mie University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: C
authors.initials: C
authors.lastname: Kishioka
authors.forename: A
authors.initials: A
authors.lastname: Yuta
authors.forename: Y
authors.initials: Y
authors.lastname: Sakakura
authors.forename: S
authors.initials: S
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Ukai
authors.forename: Y
authors.initials: Y
authors.lastname: Majima
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004391:Dust; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D004391:Dust