title: Long-term follow-up of trabeculectomy with intraoperative 5-fluorouracil for uveitis-related glaucoma.
abstract: OBJECTIVE
  To determine the effect of intraoperative application of 5-fluorouracil (5-FU) on the long-term outcome of trabeculectomy in uveitis-related glaucoma.
  
  
  METHODS
  An open, prospective, noncomparative case study to evaluate the use of intraoperative application for 5 minutes of 25 mg/ml 5-FU in primary trabeculectomy for uveitis-related glaucoma.
  
  
  METHODS
  Fifty eyes of 43 consecutive patients were enrolled in the study.
  
  
  METHODS
  Data were recorded prospectively on specifically designed forms at visits every 3 months after surgery.
  
  
  METHODS
  The intraocular pressure, need for additional medication, and the need for repeat surgery were the criteria that determined the outcome of surgery.
  
  
  RESULTS
  No significant intraoperative, postoperative, or late complications of 5-FU administration were noted. Successful filtration was achieved in 82% of eyes at 1 and 2 years after surgery. The success rate was 67% at 5 years. Failure was significantly more common and occurred earlier in patients of black ethnic origin. No deleterious effect on control of uveitis in relation to surgical intervention was observed.
  
  
  CONCLUSIONS
  Intraoperative application of 5-FU appears to be a long-term, safe, and effective adjunct to trabeculectomy in uveitis-related glaucoma.
authors.affiliation: Department of Clinical Ophthalmology, Institute of Ophthalmology, Moorfields Eye Hospital, London, England UK.
authors.forename: H M
authors.initials: HM
authors.lastname: Towler
authors.forename: P
authors.initials: P
authors.lastname: McCluskey
authors.forename: B
authors.initials: B
authors.lastname: Shaer
authors.forename: S
authors.initials: S
authors.lastname: Lightman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000963:Antimetabolites / Q000008:administration & dosage*; D002648:Child; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014130:Trabeculectomy; D014605:Uveitis / Q000150:complications* / Q000503:physiopathology
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil