Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease.
Ten unmedicated patients with Parkinson's disease received sub-threshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area (M1(HAND)) contralaterally to the more affected upper limb. Compared to a midfrontal sham-rTMS, real-rTMS over M1(HAND) was associated with a significant decrease in the global motor UPDRS score 1 h after the cessation of rTMS. This was mainly due to a clinical improvement in the arm contralaterally to the stimulated M1(HAND). These preliminary data suggest that focal rTMS of M1(HAND) may have a therapeutic potential in PD.
Siebner
H R
HR
Department of Neurology, Technische Universität München, Moehlstrasse 28, D-81675, Munich, Germany. hartwig.siebner@neuro.medmtu-muenchen.de
Rossmeier
C
C
Mentschel
C
C
Peinemann
A
A
Conrad
B
B
D004574:Electromagnetic Fields; D007839:Functional Laterality; D006225:Hand; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation / Q000627:therapeutic use*