In situ preparation of a highly active N-heterocyclic carbene-coordinated olefin metathesis catalyst.
Highly active N-heterocyclic carbene-coordinated catalysts may be synthesized and used in situ, without requiring prior isolation of the catalyst. Activation of this in situ catalyst with ethereal HCl dramatically reduces the reaction times required for high conversions. A variety of alpha,beta-unsaturated carbonyl-containing substrates participate readily in cross and ring-closing metathesis reactions using this preparation.
Morgan
J P
JP
The Arnold and Mabel Beckman Laboratories for Chemical Synthesis, California Institute of Technology, Pasadena, California 91125, USA.
Grubbs
R H
RH
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D006851:Hydrochloric Acid; D007202:Indicators and Reagents
D000475:Alkenes; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D006851:Hydrochloric Acid