title: Antiplasmodial activity of isoflavones from Andira inermis.
abstract: The stem bark and seeds of Andira inermis, Fabaceae, are employed as a purgative, vermifuge, and febrifuge. In particular, the powdered bark is claimed to be efficacious in intermittent fever. Bioassay-guided fractionation of lipophilic extracts from the stems and leaves yielded six isoflavones: biochanin A, calycosin, formononetin, genistein, pratensein, and prunetin. Calycosin (3', 7-dihydroxy-4'-methoxyisoflavone) and genistein (4',5, 7-trihydroxyisoflavone) have been shown to possess in vitro activity against the chloroquine-sensitive strain poW and the chloroquine-resistant clone Dd2 of Plasmodium falciparum.
authors.affiliation: Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Königin-Luise Str. 2-4, D-14195, Berlin, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Kraft
authors.forename: K
authors.initials: K
authors.lastname: Jenett-Siems
authors.forename: K
authors.initials: K
authors.lastname: Siems
authors.forename: M P
authors.initials: MP
authors.lastname: Gupta
authors.forename: U
authors.initials: U
authors.lastname: Bienzle
authors.forename: E
authors.initials: E
authors.lastname: Eich
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D007529:Isoflavones; D010936:Plant Extracts; D002738:Chloroquine