Rifabutin-induced uveitis with inflammatory vitreous infiltrate.
OBJECTIVE
To describe an ocular complication of rifabutin therapy in the treatment of Mycobacterium avium complex (MAC) infection in the absence of HIV infection or AIDS.


METHODS
Three patients on rifabutin therapy for MAC chest infection developed anterior uveitis with vitreous infiltrates. The clinical course and visual outcome are discussed.


RESULTS
The ocular signs of anterior segment inflammation along with vitreous infiltrate resolved on topical steroid therapy without long-term visual sequelae.


CONCLUSIONS
This report highlights the potential of uveitis in patients treated for MAC infection with rifabutin without concurrent HIV infection or AIDS.
Khan
M A
MA
Princess Alexandra Eye Pavilion, Edinburgh, UK.
Singh
J
J
Dhillon
B
B
D000368:Aged; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy; D011379:Prognosis; D017828:Rifabutin / Q000009:adverse effects*; D014606:Uveitis, Anterior / Q000139:chemically induced*; D014822:Vitreous Body
D000904:Antibiotics, Antitubercular; D017828:Rifabutin