Highly enantioselective approach to indolizidines: preparation of (+)-(1S,8aS)-1-hydroxyindolizidine and (-)-slaframine.
A highly stereoselective approach to (-)-slaframine and its probable biosynthetic precursor (+)-(1S,8aS)-1-hydroxyindolizidine has been developed based on a diastereofacially selective cycloaddition of dichloroketene with a chiral dienol ether.
Pourashraf
M
M
Université Joseph Fourier de Grenoble, Chimie Recherche (LEDSS), 38041 Grenoble Cedex, France.
Delair
P
P
Rasmussen
M O
MO
Greene
A E
AE
D000470:Alkaloids / Q000138:chemical synthesis*; D007212:Indolizines / Q000138:chemical synthesis*; D009183:Mycotoxins / Q000138:chemical synthesis*; D013237:Stereoisomerism
C416865:1-hydroxyindolizidine; D000470:Alkaloids; D007212:Indolizines; D009183:Mycotoxins; C009275:slaframine