[Immunosuppressive mechanisms for immunoglobulin function].
The article reviews the evidence supporting and explaining suppressive activity of intravenous immunoglobulin (IVIG) preparations towards human immune system. Besides basic mechanisms also clinical applications and effects in various autoimmune disorders such as idiopathic thrombocytopenia, Guillain-Barré syndrome and others are described. This evidence supports novel application of IVIG as convenient alternative to other immunosuppressive therapies with many more adverse effects.
Miller
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Zakład Immunologii Centralnego Szpitala Klinicznego Wojskowej Akademii Medycznej w Warszawie.
Jedrzejczak
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WW
D001327:Autoimmune Diseases / Q000188:drug therapy*; D001402:B-Lymphocytes / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D020275:Guillain-Barre Syndrome / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000494:pharmacology*; D007165:Immunosuppression Therapy / Q000379:methods*; D009080:Mucocutaneous Lymph Node Syndrome / Q000188:drug therapy; D009103:Multiple Sclerosis / Q000188:drug therapy; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy; D013601:T-Lymphocytes / Q000187:drug effects
D016207:Cytokines; D016756:Immunoglobulins, Intravenous