title: Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.
abstract: In order to clarify the relationship of the cyclooxygenase-2 immunoreactivity and the progression of depressed-type colorectal adenomas and cancers, we examined cyclooxygenase-2 expression in depressed-type colorectal adenomas and cancers. Immunohistochemical staining was performed by the streptavidin-biotin method. Among 100 adenomas, depressed-type were found in 15, cyclooxygenase-2 expression was not detected in depressed-types, and lesion size in depressed-types did not differ from that in others. Among 100 submucosal invasive cancers, depressed-type were found in 14, cyclooxygenase-2 expression was not detected in depressed-types, and lesion size in tumor with depressed-type did not differ from that in others. Among 100 cancers invading the muscularis propria, depressed-types in 15, cyclooxygenase-2 expression was not detected in depressed-types; these were significantly smaller lesions than those in others (p<0.05). Our results suggest that depressed-type cancers do not result from cyclooxygenase-2 expression.
authors.affiliation: First Department of Internal Medicine, Gunma University School of Medicine, Maebashi-shi, Gunma 371-8511, Japan. k-saito@mail.wind.co.jp
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: K
authors.initials: K
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Mori
mesh_terms: D000236:Adenoma / Q000201:enzymology* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D051546:Cyclooxygenase 2; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000276:immunology / Q000378:metabolism*; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000276:immunology / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases