title: Transient up-regulation of the rostrocaudal gradient of ephrin A2 in the tectum coincides with reestablishment of orderly projections during optic nerve regeneration in goldfish.
abstract: During development, a graded expression of ephrin A2 has been implicated in retinotectal map formation. Here we have examined ephrin A2 expression during optic nerve regeneration in the mature goldfish. In the tecta of normal animals, a gradient of ephrin A2 expression is detected in cell bodies within the stratum fibrosum et griseum superficiale with more immunopositive cells caudally than rostrally. The gradient in the mature animal presumably reflects the plasticity associated with continued retinal and tectal neurogenesis. During optic nerve regeneration, expression throughout the tectum is increased by 1 month as a strong rostrocaudal gradient. The gradient declines to normal by 3 months. The up-regulation of ephrin A2 during optic nerve regeneration is likely to be instrumental in reestablishing the retinotectal map.
authors.affiliation: Department of Zoology, The University of Western Australia, Nedlands, 6907, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Rodger
authors.forename: C A
authors.initials: CA
authors.lastname: Bartlett
authors.forename: L D
authors.initials: LD
authors.lastname: Beazley
authors.forename: S A
authors.initials: SA
authors.lastname: Dunlop
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000648:ultrastructure; D036383:Ephrin-A2; D006054:Goldfish / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism; D009409:Nerve Crush / Q000009:adverse effects; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009900:Optic Nerve / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism; D013477:Superior Colliculi / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology; D014795:Visual Pathways / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism
chemical_list: D036383:Ephrin-A2; D014157:Transcription Factors