title: Physical characteristics of the ECAT EXACT3D positron tomograph.
abstract: The 'EXACT3D' positron tomograph, which is now in routine clinical research use, was developed with the aim of achieving unprecedented sensitivity, high spatial and temporal resolution and simplicity of design using proven detector technology. It consists of six rings of standard detector blocks (CTI/Siemens EXACT HR+) with 4.39 mm x 4.05 mm x 30 mm elements, giving an axial field of view (FOV) of 23.4 cm. This extended FOV and the absence of interplane septa and retractable transmission rod sources has allowed greatly simplified gantry and detector cassette design. Operation in exclusive 3D mode requires an alternative to the conventional coincidence method for transmission scanning, and a single photon approach using a hydraulically driven 137Cs point source has been implemented. The tomograph has no other moving parts. A single time frame of data without any compression is very large (> 300 Mbyte) and two approaches are employed to overcome this difficulty: (a) adjacent sinograms can be summed automatically into different combinations and (b) listmode (event-by-event) acquisition has been instituted, which is both storage efficient (particularly for acquisition of sparse data sets) and maximizes temporal resolution. The high-speed I/O and computing hardware can maintain a sustained acquisition rate of about 4 million coincidence events per second. A disadvantage of the large axial FOV in 3D is the increased sensitivity to activity outside the coincidence FOV. However, this can be minimized by additional side shielding. The mean spatial resolution is 4.8 +/- 0.2 mm FWHM (transaxial, 1 cm off-axis) and 5.6 +/- 0.5 mm (axial, on-axis). Its absolute efficiency is 5.8% for a line source in air (just spanning the axial FOV) and 10% for a central point source (with thresholds of 350-650 keV). For a uniform 20 cm diameter cylinder, the efficiency is 69 kcps kBq(-1) ml(-1) (after subtraction of a scatter fraction of 42%). Sensitivity relative to the EXACT HR+ (with four rings of blocks) is 2.5 (3D) and 12 (2D) times respectively. The rate of random events in blood flow studies in the brain and body, using 15O-labelled water, can be controlled by limiting the administered dose and inserting additional side shielding.
authors.affiliation: MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
authors.forename: T J
authors.initials: TJ
authors.lastname: Spinks
authors.forename: T
authors.initials: T
authors.lastname: Jones
authors.forename: P M
authors.initials: PM
authors.lastname: Bloomfield
authors.forename: D L
authors.initials: DL
authors.lastname: Bailey
authors.forename: M
authors.initials: M
authors.lastname: Miller
authors.forename: D
authors.initials: D
authors.lastname: Hogg
authors.forename: W F
authors.initials: WF
authors.lastname: Jones
authors.forename: K
authors.initials: K
authors.lastname: Vaigneur
authors.forename: J
authors.initials: J
authors.lastname: Reed
authors.forename: J
authors.initials: J
authors.lastname: Young
authors.forename: D
authors.initials: D
authors.lastname: Newport
authors.forename: C
authors.initials: C
authors.lastname: Moyers
authors.forename: M E
authors.initials: ME
authors.lastname: Casey
authors.forename: R
authors.initials: R
authors.lastname: Nutt
mesh_terms: D002588:Cesium Radioisotopes; D004867:Equipment Design; D005857:Germanium; D006801:Humans; D007457:Iodine Radioisotopes; D019047:Phantoms, Imaging; D011868:Radioisotopes; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes; D014055:Tomography, Emission-Computed / Q000295:instrumentation* / Q000379:methods*
chemical_list: D002588:Cesium Radioisotopes; D007457:Iodine Radioisotopes; D011868:Radioisotopes; D013794:Thallium Radioisotopes; D005857:Germanium