title: Gamma probe-guided thoracoscopic surgery of small pulmonary nodules.
abstract: Video-assisted thoracic surgery (VATS) is an interesting and emerging procedure for the diagnosis and treatment of peripheral pulmonary nodules. We developed a new radioguided surgical technique for the detection during VATS of pulmonary nodules smaller than 2 cm, situated deep in the lung parenchyma and neither visible nor palpable with endoscopic instruments. The procedure is divided into two phases. Two hours before surgery 0.3 ml of a solution composed of 0.2 mL of 99mTc-labeled human serum albumin microspheres (5-10 MBq) and 0.1 mL of non-ionic contrast is injected into the lesion under CT guidance. Then the patient is submitted to VATS. During thoracoscopy a collimated probe of 11 mm diameter connected to a gamma ray detector is introduced via an 11.5 mm trocar and the pleural surface of the suspected area is scanned. A hot spot indicates the presence of the radiolabeled nodule and hence the area to be resected. We treated 39 patients with small pulmonary nodules (mean size, 8.3 mm; range, 4-19 mm). The patients were 27 men and 12 women (mean age, 60.8 years; range, 13-80 years). Nineteen patients had a history of synchronous or metachronous malignancy. In all cases the nodule was detected and resected and the resection margins were pathologically free of tumor. Histological examination showed 21 benign and 18 malignant lesions (7 metastases and 11 primary lung cancers). Nine patients with a frozen section-based histopathological diagnosis of lung cancer without functional contraindications underwent a completion lobectomy by open surgery in the same surgical session. In conclusion, the radiolocalization of small pulmonary nodules by gamma probe during VATS is a safe and easy procedure, with fewer complications and a lower failure rate than other localization techniques.
authors.affiliation: Department of Oncology, University of Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Boni
authors.forename: C R
authors.initials: CR
authors.lastname: Bellina
authors.forename: M
authors.initials: M
authors.lastname: Grosso
authors.forename: M
authors.initials: M
authors.lastname: Lucchi
authors.forename: G
authors.initials: G
authors.lastname: Manca
authors.forename: M C
authors.initials: MC
authors.lastname: Ambrogi
authors.forename: D
authors.initials: D
authors.lastname: Volterrani
authors.forename: G
authors.initials: G
authors.lastname: Menconi
authors.forename: F M
authors.initials: FM
authors.lastname: Melfi
authors.forename: A
authors.initials: A
authors.lastname: Gonfiotti
authors.forename: F
authors.initials: F
authors.lastname: Davini
authors.forename: C A
authors.initials: CA
authors.lastname: Angeletti
authors.forename: R
authors.initials: R
authors.lastname: Bianchi
authors.forename: A
authors.initials: A
authors.lastname: Chella
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D013906:Thoracoscopy / Q000379:methods*; D014743:Videotape Recording
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin