title: Delayed gastric emptying in human immunodeficiency virus infection: correlation with symptoms, autonomic function, and intestinal motility.
abstract: Gastric emptying may be delayed in HIV infection. We aimed to characterize the pattern of gastric emptying in HIV seropositive subjects and correlate the findings with symptoms, as well as to identify possible etiological factors. Solid gastric emptying was measured using scintigraphy in 54 HIV seropositive subjects and 12 HIV seronegative controls. Gastrointestinal symptoms were evaluated using a standardized numerical score, and autonomic function was assessed using spectral analysis of heart rate variability. Fasting and postprandial duodenojejunal activity was recorded using strain gauge manometry catheters. Gastric emptying rate, but not lag phase, was significantly delayed in HIV-infected subjects, particularly those with enteric infections and more advanced disease. Delayed gastric emptying did not correlate with symptoms, autonomic dysfunction, or small intestinal motility. In conclusion, abnormalities found in autonomic function and gastric emptying in HIV infection are multifactorial in nature. The contribution of upper gastrointestinal motor dysfunction to gastric symptoms in such individuals is unclear.
authors.affiliation: Department of HIV Medicine and Nuclear Medicine, Chelsea and Westminster Hospital, London, England.
authors.forename: P J
authors.initials: PJ
authors.lastname: Neild
authors.forename: K S
authors.initials: KS
authors.lastname: Nijran
authors.forename: E
authors.initials: E
authors.lastname: Yazaki
authors.forename: D F
authors.initials: DF
authors.lastname: Evans
authors.forename: D L
authors.initials: DL
authors.lastname: Wingate
authors.forename: R
authors.initials: R
authors.lastname: Jewkes
authors.forename: B G
authors.initials: BG
authors.lastname: Gazzard
mesh_terms: D000328:Adult; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology*; D004386:Duodenum / Q000503:physiopathology; D005746:Gastric Emptying / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology*; D015658:HIV Infections / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007583:Jejunum / Q000503:physiopathology; D008875:Middle Aged; D011446:Prospective Studies