title: [Drug stimulation of the peripheral nerve regeneration].
abstract: A comparative study of the effects of xymedone, riboxin, and piracetam upon the regeneration of myelinated axons and the number of surviving sensory neurons in spinal ganglia L4-L5 was studied on the model of sciatic nerve transection in rats. The three drugs decrease the number of neurons entering the posttraumatic apoptosis. Riboxin and xymedone stimulate the regeneration of myelinated axons, the latter drug being more effective and producing a 21.3 and 14.7% increase in the number of regenerated myelinated axons and a 29.3 and 37.7% increase in the relative number of sensory neurons (the transected/contralateral side ratio) in spinal ganglia L4-L5 relative to control by the 60th and 90th day upon transection, respectively.
authors.affiliation: Histology Department, State Medical University, Kazan, Tatarstan, Russia.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Chelyshev
authors.forename: R Kh
authors.initials: RKh
authors.lastname: Khafiz'ianova
authors.forename: I S
authors.initials: IS
authors.lastname: Raginov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Vafin
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D005727:Ganglia, Spinal / Q000166:cytology; D007290:Inosine Diphosphate / Q000494:pharmacology*; D009186:Myelin Sheath / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology
chemical_list: D018697:Nootropic Agents; D011743:Pyrimidines; C069705:xymedon; D007290:Inosine Diphosphate; D010889:Piracetam