[Analysis of bronchial hypersensitivity in patients with bronchial asthma].
OBJECTIVE
To analyse correlation between bronchial hypersensitivity in bronchial asthma (BA) and environmental factors; to propose methods of relevant correction.


METHODS
The trial included 97 BA patients (42 males, 55 females) aged 17-79 years. Bronchial sensitivity was studied by means of dose-dependent bronchial resistance curve (Rrs) plotted by the unit Masterlab (Germany) in the course of long-term inhalation of a gradually rising dose of methacholine. A regression analysis was made of the dependence of fluticasone bipropionate effectiveness on clinical symptoms of the disease.


RESULTS
Bronchial hypersensitivity depends on initial clinical symptoms of BA, in a less degree on bronchial permeability, severity of inflammation of bronchial mucosa.


CONCLUSIONS
Local corticosteroid fluticasone propionate is a drug of choice in the treatment of mild and moderate BA.
Ubaĭdullaev
A M
AM
Uzakova
G T
GT
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology*; D000730:Androstadienes / Q000008:administration & dosage / Q000627:therapeutic use; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis* / Q000503:physiopathology; D001985:Bronchial Provocation Tests / Q000379:methods; D016085:Bronchoconstrictor Agents / Q000008:administration & dosage; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage; D008875:Middle Aged; D012044:Regression Analysis; D012720:Severity of Illness Index
D000730:Androstadienes; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D000068298:Fluticasone