The 5-HT(2C/2B) receptor agonist, m-chlorophenylpiperazine, increases plasma glucagon levels in rats.
Effects of the 5-HT(2C/2B) receptor agonist m-chlorophenylpiperazine (mCPP) on plasma glucagon levels were investigated in rats. mCPP dose dependently increased plasma glucagon levels. Hyperglucagonemia elicited by mCPP was prevented by the 5-HT(2A/2B/2C) receptor antagonist, ritanserin, while the 5-HT(2A) receptor antagonist, ketanserin, did not show any effect. Increases in glucagon levels induced by mCPP were inhibited by prior adrenodemedullation. These results indicate that increases in plasma glucagon levels induced by mCPP are mediated by the 5-HT(2C/2B) receptor which in turn facilitates adrenaline release.
Yamada
J
J
Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-machi, Higashinada-ku, 658-8558, Kobe, Japan. j-yamada@kobepharma-u.ac.jp
Sugimoto
Y
Y
D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005934:Glucagon / Q000097:blood / Q000187:drug effects*; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044402:Receptor, Serotonin, 5-HT2A; D044403:Receptor, Serotonin, 5-HT2B; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000187:drug effects; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
D001786:Blood Glucose; D010879:Piperazines; D044402:Receptor, Serotonin, 5-HT2A; D044403:Receptor, Serotonin, 5-HT2B; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D016713:Ritanserin; D005934:Glucagon; D007650:Ketanserin; C015068:1-(3-chlorophenyl)piperazine