title: Effect of methylene blue on the disposition of ethanol.
abstract: The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [(14)C]ethanol to (14)CO(2) in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by the increase in the [lactate]/[pyruvate] ratio.
authors.affiliation: Department of Medicine, Kantonsspital Baden, Bern, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Vonlanthen
authors.forename: J H
authors.initials: JH
authors.lastname: Beer
authors.forename: B H
authors.initials: BH
authors.lastname: Lauterburg
mesh_terms: D000328:Adult; D000818:Animals; D002492:Central Nervous System Depressants / Q000097:blood / Q000493:pharmacokinetics*; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics*; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D008751:Methylene Blue / Q000493:pharmacokinetics*; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002492:Central Nervous System Depressants; D004791:Enzyme Inhibitors; D019344:Lactic Acid; D000431:Ethanol; D019289:Pyruvic Acid; D008751:Methylene Blue