Postmenopausal smokers show reduced hemodynamic benefit from oral hormone replacement.
With use of a randomized, placebo-controlled trial, 62 healthy, postmenopausal smokers and nonsmokers were tested for resting and stress-induced hemodynamic variables before and after 6 months of treatment with either oral hormone replacement therapy or placebo. Smokers had significantly less reduction in both resting and stress-induced vascular resistance and blood pressure after treatment with oral hormone replacement therapy than nonsmokers.
Girdler
S S
SS
University of North Carolina at Chapel Hill, 27599-7175, USA.
Hinderliter
A L
AL
West
S G
SG
Grewen
K
K
Steege
J
J
Light
K C
KC
D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D020249:Hormone Replacement Therapy; D006801:Humans; D008525:Medroxyprogesterone / Q000494:pharmacology; D017698:Postmenopause / Q000502:physiology*; D012907:Smoking / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects
D004966:Estrogens, Conjugated (USP); D008525:Medroxyprogesterone