title: [Anti-arrhythmic effect of phytoadaptogens].
abstract: Repeated prophylactic administration of plant adaptogen preparations based on extracts from rhodiola, eleutherococcus, leuzea, and ginseng, produced a pronounced antiarrhythmic effect on the model of adrenal arrhythmia in animals. Preliminary opioid receptor block by naloxone reduced the protective effect of phytopreparations in the adapted animals. Intravenous and intracerebroventricular administration of naloxone (opioid receptor antagonist) showed that the anti-arrhythmic effect of rhodiola extract proceeds through the activation of both central and peripheral opioid receptors.
authors.affiliation: Laboratory of Experimental Cardiology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Maĭmeskulova
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
mesh_terms: D000322:Adrenergic Agonists; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D004837:Epinephrine; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000187:drug effects*
chemical_list: D000322:Adrenergic Agonists; D000889:Anti-Arrhythmia Agents; D009292:Narcotic Antagonists; D010936:Plant Extracts; D011957:Receptors, Opioid; D009270:Naloxone; D004837:Epinephrine