In vitro activity of Rutaceae species against the trypomastigote form of Trypanosoma cruzi.
The activity of crude plant extracts of nine species of Rutaceae against the trypomastigote form of Trypanosoma cruzi was evaluated at 4 mg/ml. Thirty-two crude extracts were tested and eight of them showed significant activity (>80%). The most active extract was obtained from the stems of Pilocarpus spicatus (97.3%). Fractionation of the active crude extracts provided 25 fractions which were tested against the trypomastigote form of T. cruzi at 2 mg/ml. Of these six showed significant activity (>80%). The most active fractions (100%) were obtained from the leaves of Almeidea coerulea (butanol fraction) and Conchocarpus inopinatus (dichloromethane fraction).
Mafezoli
J
J
Departamento de Química, Universidade Federal de São Carlos-UFSCar, Via Washington Luiz, Km 235, C.P. 676, 13565-905, SP, São Carlos, Brazil.
Vieira
P C
PC
Fernandes
J B
JB
da Silva
M F
MF
de Albuquerque
S
S
D000818:Animals; D019448:Ethnobotany; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D010936:Plant Extracts; D014344:Trypanocidal Agents