A diastereocontrolled synthesis of (+)-febrifugine: a potent antimalarial piperidine alkaloid.
A diastereocontrolled synthesis of (+)-febrifugine, a potent antimalarial piperidine alkaloid, has been achieved using a chiral block having a bicyclo[3.2.1]octane framework which exhibits inherent convex-face selectivity.
Taniguchi
T
T
Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan.
Ogasawara
K
K
D000470:Alkaloids / Q000138:chemical synthesis*; D000962:Antimalarials / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*; D010946:Plants, Medicinal / Q000737:chemistry; D011799:Quinazolines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000470:Alkaloids; D000962:Antimalarials; D010880:Piperidines; D011799:Quinazolines; C001207:febrifugine