title: Simulation of electrophoretic separations by the flux-corrected transport method.
abstract: Electrophoretic separations at typical experimental electric field strengths have been simulated by applying the flux-corrected transport (FCT) finite difference method to the transient, one-dimensional electrophoresis model. The performance of FCT on simulations of zone electrophoresis (ZE), isotachophoresis (ITP), and isoelectric focusing (IEF) has been evaluated. An FCT algorithm, with a three-point, central spatial discretization, yields numerical solutions without numerical oscillations or spurious peaks, which have plagued previously-published second-order solutions to benchmark ZE and ITP problems. Moreover, the FCT technique captures sharp zone boundaries and IEF peaks more accurately than previously-published, first-order upwind schemes.
authors.affiliation: Department of Chemical and Environmental Engineering, The University of Arizona, Tucson 85721. USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Sounart
authors.forename: J C
authors.initials: JC
authors.lastname: Baygents
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004560:Electricity; D004586:Electrophoresis / Q000379:methods*