title: Chronic parvovirus B-19 meningoencephalitis with additional detection of Epstein-Barr virus DNA in the cerebrospinal fluid of an immunocompetent patient.
abstract: Parvovirus B19 DNA was detected by polymerase chain reaction in the brain biopsy specimen from a 67-year-old immunocompetent woman with severe chronic lymphocytic meningoencephalitis. In addition to parvovirus B19, Epstein-Barr virus DNA was identified in the CSF. Genomic material from Epstein-Barr virus was absent in the brain tissue. Clinical symptoms and CSF pleocytosis improved under long-term corticosteroid-treatment. The aetio-pathogenetic role of parvovirus B19 and the possible meaning of the additionally detected Epstein-Barr virus DNA are discussed.
authors.affiliation: Department of Neurology, University of Erlangen-Nuernberg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Druschky
authors.forename: J
authors.initials: J
authors.lastname: Walloch
authors.forename: J
authors.initials: J
authors.lastname: Heckmann
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: H
authors.initials: H
authors.lastname: Stefan
authors.forename: B
authors.initials: B
authors.lastname: Neundörfer
mesh_terms: D000368:Aged; D001706:Biopsy; D001921:Brain / Q000473:pathology / Q000821:virology; D002908:Chronic Disease; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007121:Immunocompetence; D008587:Meningitis, Viral / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D010322:Parvoviridae Infections / Q000175:diagnosis* / Q000276:immunology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*
chemical_list: D004279:DNA, Viral