Pauci-immune ANCA-positive crescentic glomerulonephritis associated with metastatic adenocarcinoma of the lung.
A 66-year-old woman developed rapidly progressive renal failure several days after she was diagnosed with non-small cell carcinoma of the lung. Antineutrophil cytoplasmic antibody test performed as an indirect immunofluorescence assay was positive with a perinuclear pattern of staining (pANCA). The patient did not improve with hemodialysis treatment and died on the second day after admission to the hospital. A complete autopsy was performed and showed metastatic adenocarcinoma of the lung and pauci-immune crescentic glomerulonephritis. A literature search showed only 7 previously reported cases of malignant tumors associated with ANCA-positive pauci-immune crescentic glomerulonephritis. The clinicopathologic findings of the current and all previously reported cases and possible relationship between ANCA-positive glomerulonephritis and malignancy are discussed.
Baschinsky
D Y
DY
Ohio State University Medical Center and Arthur G. James Cancer Hospital and Research Institute, Columbus, OH, USA.
Baker
P B
PB
Niemann
T H
TH
Wilmer
W A
WA
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000473:pathology; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D009362:Neoplasm Metastasis
D019268:Antibodies, Antineutrophil Cytoplasmic