Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins.
Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.
Plater
M J
MJ
Department of Chemistry, University of Aberdeen, Scotland, UK.
Murdoch
A M
AM
Morphy
J R
JR
Rankovic
Z
Z
Rees
D C
DC
D000577:Amides; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D007202:Indicators and Reagents; D012116:Resins, Plant
D000577:Amides; D000588:Amines; D007202:Indicators and Reagents; D012116:Resins, Plant