Application of nitric oxide for a case of veno-occlusive disease after peripheral blood stem cell transplantation.
A 5-year-old girl at high risk for acute lymphoblastic leukemia was treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT). However, her condition was complicated by veno-occlusive disease of the liver (VOD) after PBSCT. For treatment of VOD, transdermal isosorbide tape was applied as a nitric oxide (NO) donor. The signs of VOD improved immediately after NO treatment was initiated, and the patient showed no side effects from the transdermal isosorbide tape.
Kajiume
T
T
Satou Memorial Hospital, Okayama, Japan. kajiume@d4.dion.ne.jp
Yoshimi
S
S
Nagita
A
A
Kobayashi
K
K
Kataoka
N
N
D000279:Administration, Cutaneous; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007547:Isosorbide / Q000008:administration & dosage; D009569:Nitric Oxide / Q000008:administration & dosage*; D020030:Nitric Oxide Donors / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000628:therapy
D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D007547:Isosorbide