title: Chronic myelomonocytic leukaemia in a child with constitutional partial trisomy 8 mosaicism.
abstract: We present a 3-year-old boy with constitutional partial trisomy 8 mosaicism (karyotype 47,XY, + del(8)(p12)/46,XY) who developed chronic myelomonocytic leukaemia and we review the few reported cases of constitutional trisomy 8 mosaicism (CT8M) associated with malignancy. This case highlights the association between CT8M and the development of malignancies, haematological malignancies in particular.
authors.affiliation: Kennedy-Galton Centre, North West London Hospitals NHS Trust, Harrow, Middlesex, UK. a.brady@ic.ac.uk
authors.forename: A F
authors.initials: AF
authors.lastname: Brady
authors.forename: C S
authors.initials: CS
authors.lastname: Waters
authors.forename: M J
authors.initials: MJ
authors.lastname: Pocha
authors.forename: L A
authors.initials: LA
authors.lastname: Brueton
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D009030:Mosaicism / Q000235:genetics*; D010641:Phenotype; D014314:Trisomy / Q000235:genetics*