title: [Serum tyrosine in children with phenylketonuria and mild hyperphenylalaninemia].
abstract: Serum tyrosine concentration, Phe/Tyr scores and psychomotor/mental development scores were analysed in 32 children with phenylketonuria (PKU) and 39 with mild hyperphenylalaninaemia. Observation period included the first 6 years of life. Tendency to tyrosine deficiency was observed; stronger in dietary treated PKU patients than in those with mild hyperphenylalaninaemia. Statistically significant differences between patient groups were found only in 3 and 6 years old children (lower tyrosine values in PKU patients). It was observed that evaluation of Phe/Tyr score value might be usefull in differentiation between PKU and mild hyperphenylalaninaemia. Moreover, the above score may help in the evaluation of hypo- and hyperalimentation state in the course of dietary treatment. The level of tyrosine deficiency in the analysed patient groups did not influence their normal intellectual development.
authors.affiliation: Klinika Pediatrii, Instytut Matki i Dziecka w Warszawie.
authors.forename: B
authors.initials: B
authors.lastname: Cabalska
authors.forename: M
authors.initials: M
authors.lastname: Nowacka
authors.forename: T
authors.initials: T
authors.lastname: Laskowska-Klita
authors.forename: I
authors.initials: I
authors.lastname: Nowaczewska
authors.forename: K
authors.initials: K
authors.lastname: Zorska
authors.forename: W
authors.initials: W
authors.lastname: Taljański
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D010649:Phenylalanine / Q000097:blood*; D010661:Phenylketonurias / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000178:diet therapy; D014443:Tyrosine / Q000097:blood / Q000172:deficiency*
chemical_list: D014443:Tyrosine; D010649:Phenylalanine