title: A space-time adaptive method for simulating complex cardiac dynamics.
abstract: For plane-wave and many-spiral states of the experimentally based Luo-Rudy 1 model of heart tissue in large (8 cm square) domains, we show that a space-time-adaptive time-integration algorithm can achieve a factor of 5 reduction in computational effort and memory-but without a reduction in accuracy-when compared to an algorithm using a uniform space-time mesh at the finest resolution. Our results indicate that such an algorithm can be extended straightforwardly to simulate quantitatively three-dimensional electrical dynamics over the whole human heart.
authors.affiliation: Department of Computer Science, Duke University, P.O. Box 90129, Durham, North Carolina 27708-0129, USA. emc@cs.duke.edu
authors.forename: E M
authors.initials: EM
authors.lastname: Cherry
authors.forename: H S
authors.initials: HS
authors.lastname: Greenside
authors.forename: C S
authors.initials: CS
authors.lastname: Henriquez
mesh_terms: D000465:Algorithms; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D004594:Electrophysiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular