title: Serum alhpa 1-acid glycoprotein concentrations in healthy and tumor-bearing cats.
abstract: The purpose of this study was to evaluate alpha 1-acid glycoprotein (AGP) concentrations in tumor-bearing and healthy cats. The hypothesis of the present study was that AGP concentrations would be significantly increased in tumor-bearing cats. Serum from 51 healthy and 97 tumor-bearing, client-owned cats was harvested at the time of presentation and stored at -80 degrees C until assayed. Cats with measurable, histologically confirmed malignancies, and healthy cats of similar ages were included. Serum was assayed for AGP concentration by using a radial immunodiffusion method. AGP concentrations were significantly (P = .0051) higher in tumor-bearing (763 +/- 595 microg/mL; mean +/- SD) when compared to healthy cats (501 +/- 377 microg/mL; mean +/- SD). Of the tumor-bearing cats, 35 had carcinomas, 33 had sarcomas, and 26 had discrete, round cell tumors. AGP concentrations were 645 +/- 62 microg/mL, 660 +/- 540 microg/mL, and 967 +/- 860 microg/mL, respectively, and there were no significant differences among the groups.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA. kselting@vth.colostate.edu
authors.forename: K A
authors.initials: KA
authors.lastname: Selting
authors.forename: G K
authors.initials: GK
authors.lastname: Ogilvie
authors.forename: S E
authors.initials: SE
authors.lastname: Lana
authors.forename: M J
authors.initials: MJ
authors.lastname: Fettman
authors.forename: K L
authors.initials: KL
authors.lastname: Mitchener
authors.forename: R A
authors.initials: RA
authors.lastname: Hansen
authors.forename: K L
authors.initials: KL
authors.lastname: Richardson
authors.forename: J A
authors.initials: JA
authors.lastname: Walton
authors.forename: M A
authors.initials: MA
authors.lastname: Scherk
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000097:blood* / Q000473:pathology; D002415:Cats / Q000097:blood*; D005779:Immunodiffusion / Q000662:veterinary; D009961:Orosomucoid / Q000032:analysis*; D012044:Regression Analysis; D012509:Sarcoma / Q000097:blood / Q000473:pathology / Q000662:veterinary*
chemical_list: D009961:Orosomucoid