Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development.
Secreted frizzled related proteins (Sfrps) are thought to bind and regulate Wnt activity through a cysteine rich domain that is highly similar to that of Frizzled receptors. To investigate possible roles for Sfrps in chick development, we have isolated partial cDNAs encoding Sfrp-1 and Sfrp-2 and have thoroughly characterized the expression patterns of both genes. Both sfrp-1 and sfrp-2 are expressed at all stages of development analyzed, ranging from Hamburger and Hamilton stage 4 through stage 32. Expression of both sfrp-1 and sfrp-2 is observed in mesodermal and ectodermal derivatives, while sfrp-1 is also found in endodermal lineages.
Terry
K
K
Department of Biology, San Francisco State University, San Francisco CA 94132, USA.
Magan
H
H
Baranski
M
M
Burrus
L W
LW
D000818:Animals; D002642:Chick Embryo; D018076:DNA, Complementary; D005121:Extremities / Q000196:embryology; D015870:Gene Expression; D005807:Genes, Overlapping; D006023:Glycoproteins / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins; D009432:Neural Crest / Q000378:metabolism; D011506:Proteins / Q000235:genetics*; D019170:Somites / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D000099274:Frizzled-Related Proteins
D018076:DNA, Complementary; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D011506:Proteins; D000099274:Frizzled-Related Proteins