title: Antisense therapy in cancer.
abstract: This review discusses laboratory and clinical studies of antisense oligodeoxynucleotides as potential treatments for haematological malignancies and solid tumours. Mechanisms of action, pharmacokinetics, toxicities and potential clinical applications of these agents are described.
authors.affiliation: Department of Oncology, Central Clinical Hospital of Military Medical Academy, Warsaw, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Pawlak
authors.forename: J
authors.initials: J
authors.lastname: Zolnierek
authors.forename: T
authors.initials: T
authors.lastname: Sarosiek
authors.forename: C
authors.initials: C
authors.lastname: Szczylik
mesh_terms: D017209:Apoptosis; D001692:Biological Transport; D018432:Drug Resistance, Multiple; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D016376:Oligonucleotides, Antisense / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009857:Oncogenes / Q000235:genetics
chemical_list: D016376:Oligonucleotides, Antisense