The neuroprotective effects of (-)deprenyl in the gerbil hippocampus following transient global ischemia.
(-)Deprenyl (selegeline) is a monoamine oxidase B (MAO-B) inhibitor, but it also exerts several effects independent of MAO-B inhibition. For example, it has been shown to improve neuronal survival in different neurodegenerative models. In the present study, we have tested whether (-)deprenyl attenuates the neuronal damage in the hippocampus that is induced in a model of transient global ischemia in gerbils. (-)Deprenyl was administered 1) at a low daily dose starting two weeks before occlusion, 2) at a single high dose administered 3h after occlusion, or 3) at a low daily dose for one or two weeks after occlusion. A nonsignificant trend of reduced neuronal damage in the hippocampal CA1 area was seen in all experimental groups treated with (-)deprenyl, regardless of the timing of treatment. The results together with previous evidence suggest that (-)deprenyl may protect CA1 neurons from ischemia-induced delayed death by several possible mechanisms, including the suppression of oxidative stress and apoptotic processes.
Kuhmonen
J
J
Department of Neuroscience and Neurology, and University of Kuopio, Finland.
Jolkkonen
J
J
Department of Neuroscience and Neurology, and University of Kuopio, Finland.|A.I. Virtanen Institute, University of Kuopio, Kuopio, andTurku, Finland
Haapalinna
A
A
Orion Corporation, Orion Pharma, Turku, Finland, Finland
Sivenius
J
J
Department of Neuroscience and Neurology, and University of Kuopio, Finland.
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D005260:Female; D005849:Gerbillinae; D006624:Hippocampus / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D017966:Pyramidal Cells / Q000187:drug effects* / Q000473:pathology; D012642:Selegiline / Q000494:pharmacology* / Q000627:therapeutic use
D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline