Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.
We demonstrate that HLA-G, a nonclassical major histocompatibility complex class I antigen, is expressed in muscle fibers in various inflammatory myopathies. Further, interferon-gamma induces surface expression and upregulation of mRNA transcripts corresponding to different isoforms of HLA-G in myoblasts cultured from control subjects and patients. HLA-G may have important immunological functions in inflammatory myopathies and other local immune reactions as they occur during vaccination, myoblast transplantation, and gene therapy.
Wiendl
H
H
Department of Neuroimmunology, Max-Planck-Institute for Neurobiology, Martinsreid, Germany.
Behrens
L
L
Maier
S
S
Johnson
M A
MA
Weiss
E H
EH
Hohlfeld
R
R
D002478:Cells, Cultured / Q000276:immunology / Q000473:pathology; D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D009132:Muscles / Q000276:immunology / Q000473:pathology*; D009220:Myositis / Q000276:immunology / Q000473:pathology*; D016133:Polymerase Chain Reaction
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I