title: Manometric and pH-metric features in gastro-oesophageal reflux disease patients with and without Helicobacter pylori infection.
abstract: BACKGROUND
  The role of Helicobacter pylori in the pathogenesis and evolution of gastro-oesophageal reflux disease is still debated.
  
  
  OBJECTIVE
  To investigate the impact of Helicobacter pylori infection on the oesophageal function and on intra-gastric and intra-oesophageal pH in patients with gastro-oesophageal reflux.
  
  
  METHODS
  Fifty patients with non-complicated-gastro-oesophageal reflux disease classified according to Savary-Miller in: grade O, n=24; grade 1, n=19; grade 2, n=6; grade 3, n=1. Of these patients, 24 were Helicobacter pylori positive and 26 negative. Patients underwent, on two different days, stationary oesophageal manometry and 24-hour gastro-oesophageal pH-metry.
  
  
  RESULTS
  No difference was observed between Helicobacter pylori infected and non-infected individuals with regard to lower oesophageal sphincter function, oesophageal peristalsis and gastrooesophageal reflux. These parameters were more impaired in individuals with erosive gastro-oesophageal reflux disease but this result was not dependent on the Helicobacter pylori status. Helicobacter pylori did not influence the pattern of gastric pH; however, considering only individuals with non-erosive gastro-oesophageal reflux disease, gastric pH was significantly higher in infected individuals, who, histologically, also showed a corpus predominant gastritis.
  
  
  CONCLUSIONS
  In patients with gastro-oesophageal reflux disease, Helicobacter pylori does not affect the oesophageal motility or the gastro-oesophageal reflux. These parameters are strictly related to the severity of gastro-oesophageal reflux disease as assessed at endoscopy. In patients with non-erosive gastro-oesophageal reflux disease, a corpus predominant Helicobacter pylori gastritis could be responsible for the less severe gastro-oesophageal reflux.
authors.affiliation: Department of Gastroenterology, Cardarelli Hospital, Naples, Italy. gimanes@tin.it
authors.forename: G
authors.initials: G
authors.lastname: Manes
authors.forename: P
authors.initials: P
authors.lastname: Esposito
authors.forename: M
authors.initials: M
authors.lastname: Lioniello
authors.forename: A
authors.initials: A
authors.lastname: Bove
authors.forename: S
authors.initials: S
authors.lastname: Mosca
authors.forename: A
authors.initials: A
authors.lastname: Balzano
mesh_terms: D000328:Adult; D000368:Aged; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000150:complications / Q000503:physiopathology*; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged