The relationship of angiotensin-converting enzyme gene to essential hypertension and drug treatment in Chongqing.
OBJECTIVE
To measure and discuss the association of the angiotensin converting enzyme (ACE) gene insertion/deletion(I/D) polymorphism with essential hypertension and drug treatment in Chongqing.


METHODS
Polymerase chain reaction(PCR) method was used to amplify the sixteenth intron of the ACE gene for the analysis of 114 healthy controls and 75 patients with essential hypertension. At the same time, 49 patients with essential hypertension were randomly divided into two groups for a placebo-controlled crossover comparison of ACEI versus CCB.


RESULTS
The frequency of homozygous alleles DD and the frequency of deletion alleles were significantly higher in the essential hypertension group than in the healthy controls(P>0.005). The blood pressure decreased more in the DD genotype subjects when treated with the ACEI but decreased less when treated with the CCB (15.91 vs 12.43, P<0.1). The blood pressure decreased more in the II genotype subjects when treated with the CCB but decreased less when treated with the ACEI (16.55 vs 9.6, P<0.05).


CONCLUSIONS
The results indicate that a deletion (DD) polymorphism of the ACE gene is associated with essential hypertension in Chongqing. Detection of the ACE genotype in clinics is helpful to the selection of antihypertensive drugs.
Liu
Q
Q
Department of Core Laboratory and Department of Cardiology, the First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing, 400016 P.R.China. qingliu@public.cta.cq.cn
Lei
H
H
Wang
X
X
D000328:Adult; D000368:Aged; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A