Dimebon improves learning in animals with experimental Alzheimer's disease.
Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial deprivation of cerebral cholinergic functions caused by intracerebroventricular injections of AF64A. The effects of dimebon on learning are similar to those of tacrine used in the treatment of Alzheimer's disease.
Lermontova
N N
NN
Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region.
Lukoyanov
N V
NV
Serkova
T P
TP
Lukoyanova
E A
EA
Bachurin
S O
SO
D000544:Alzheimer Disease / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001388:Aziridines / Q000494:pharmacology; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004195:Disease Models, Animal; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013619:Tacrine / Q000494:pharmacology
D001388:Aziridines; D002800:Cholinesterase Inhibitors; D006634:Histamine H1 Antagonists; D007211:Indoles; D009466:Neuromuscular Blocking Agents; D013619:Tacrine; C044894:ethylcholine aziridinium; D002794:Choline; C010119:latrepirdine