Familial adenomatous polyposis, hereditary nonpolyposis colon cancer, and familial risk: what are the implications for the surgeon?
Recent advances in the understanding of the molecular biology of colorectal cancer have resulted in many new implications for surgeons. To continue providing sound patient care, surgeons must familiarize themselves with associated issues that include genetic counseling and its role in patient and family management. Issues related to genetic counseling are reviewed in this article. Recommendations for surgical therapy and surveillance methods are summarized for each of the hereditary syndromes. Failure to use these patient management tools in an effective way may be a source of future litigation.
Thorson
A G
AG
Section of Colon and Rectal Surgery, Department of Surgery, Creighton University School of Medicine, Omaha, Nebraska, USA.
Faria
J
J
D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000517:prevention & control / Q000601:surgery; D003110:Colonic Neoplasms / Q000235:genetics* / Q000517:prevention & control / Q000601:surgery; D003111:Colonic Polyps / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D005260:Female; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D010375:Pedigree; D018570:Risk Assessment; D014481:United States