title: [Characteristics of drug resistance of tumor plasmocytes in vitro in patients with multiple myeloma differently responsive to chemotherapy].
abstract: OBJECTIVE
  To determine sensitivity of tumor plasmocytes in vitro to cytostatic drugs (prednisolone, alkeran belustin, vincristine, rubomycin, doxorubicin, cytarabin, methotrexate, cysplatin, etoposide).
  
  
  METHODS
  The sensitivity was measured with DISC method in 12 patients with multiple myeloma (MM) in two groups: resistant and responsive to induction polychemotherapy (PCT).
  
  
  RESULTS
  The groups appeared significantly different by lowering of pathological paraprotein concentration (PIg): by 7.4 +/- 2.5% and 32.5 +/- 3.7%, respectively (p < 0.05). The resistance to the drugs was higher in the resistant patients than in the responders (0.7 +/- 0.28 versus 0.4 +/- 0.02, p < 0.05). PCT schemes of resistant patients contained 65.0 +/- 2.3% of ineffective drugs. In the responders the percentage was 35.7 +/- 5.3% (p < 0.05).
  
  
  CONCLUSIONS
  The relationship exists between resistance of tumor plasmocytes to drugs in vitro and clinical findings.
authors.forename: A K
authors.initials: AK
authors.lastname: Golenkov
authors.forename: E V
authors.initials: EV
authors.lastname: Trifonova
authors.forename: E V
authors.initials: EV
authors.lastname: Kataeva
authors.forename: A V
authors.initials: AV
authors.lastname: Kil'diushevskiĭ
authors.forename: T D
authors.initials: TD
authors.lastname: Lutskaia
authors.forename: E A
authors.initials: EA
authors.lastname: Zariad'eva
authors.forename: I N
authors.initials: IN
authors.lastname: Nazarova
authors.forename: M N
authors.initials: MN
authors.lastname: Lukashina
authors.forename: T N
authors.initials: TN
authors.lastname: Zabotina
authors.forename: I N
authors.initials: IN
authors.lastname: Mikhaĭlova
authors.forename: A N
authors.initials: AN
authors.lastname: Inshakov
authors.forename: N P
authors.initials: NP
authors.lastname: Logacheva
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Baryshnikov
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000473:pathology*; D010950:Plasma Cells / Q000187:drug effects* / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents