Syndrome of hypokalemic metabolic alkalosis and hypomagnesemia associated with gentamicin therapy: case reports.
Nephrotoxicity, as evidenced by renal insufficiency is a well-known consequence of gentamicin therapy. We report two patients with gentamicin-induced syndrome of hypokalemic metabolic alkalosis and hypomagnesemia. Both had complete recovery of renal tubular function after cessation of antibiotic therapy. These cases emphasize the need to routinely monitor patients receiving gentamicin therapy for electrolyte abnormalities to avoid potential morbidity.
Shetty
A K
AK
Department of Pediatrics, Louisiana State University Medical Center and Children's Hospital, New Orleans, USA.
Rogers
N L
NL
Mannick
E E
EE
Aviles
D H
DH
D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D000471:Alkalosis / Q000139:chemically induced*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003428:Cross Infection / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced*; D007223:Infant; D007275:Injections, Intravenous; D008275:Magnesium Deficiency / Q000139:chemically induced*; D008297:Male; D016106:Methicillin Resistance; D013577:Syndrome; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D005839:Gentamicins