title: Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins.
abstract: Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.
authors.affiliation: Department of Chemistry, University of Aberdeen, Scotland, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Plater
authors.forename: A M
authors.initials: AM
authors.lastname: Murdoch
authors.forename: J R
authors.initials: JR
authors.lastname: Morphy
authors.forename: Z
authors.initials: Z
authors.lastname: Rankovic
authors.forename: D C
authors.initials: DC
authors.lastname: Rees
mesh_terms: D000577:Amides; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D007202:Indicators and Reagents; D012116:Resins, Plant
chemical_list: D000577:Amides; D000588:Amines; D007202:Indicators and Reagents; D012116:Resins, Plant