Treatment of solid tumours in children with tumour-lysate-pulsed dendritic cells.
Dendritic cells are potent stimulators of antigen-specific immune responses, including antitumour responses. We explored the use of tumour-lysate-pulsed dendritic cells in children with relapsed solid tumours. Dendritic cell treatment in children was feasible and apparently not toxic. The treatment was able to produce significant tumour regression in a child with metastatic fibrosarcoma.
Geiger
J
J
Hutchinson
R
R
Hohenkirk
L
L
McKenna
E
E
Chang
A
A
Mulé
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005354:Fibrosarcoma / Q000556:secondary / Q000628:therapy*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D015847:Interleukin-4 / Q000008:administration & dosage / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D013125:Spinal Neoplasms / Q000556:secondary / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D015847:Interleukin-4; D016178:Granulocyte-Macrophage Colony-Stimulating Factor