title: Trisomy 14 with thrombocytosis and monocytosis.
abstract: It has been reported that trisomy 14 is associated with myeloid malignancies, but a case with increased platelet count has also been reported. However, the clinical significance of trisomy 14 is still uncertain. We report a patient with trisomy 14 with thrombocytosis and a gradual increase in monocytosis. He was treated with hydroxyurea, cytarabine and aclarubicin in low doses and his quality of life was maintained for a period of about 1 year from blastic crisis. Hydroxyurea, cytarabine or aclarubicin in low doses may be the treatment of choice for trisomy 14 patients with respect to the patients' quality of life.
authors.affiliation: Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kaya
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Okafuji
authors.forename: Y
authors.initials: Y
authors.lastname: Terasaki
authors.forename: K
authors.initials: K
authors.lastname: Maeno
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Ohtake
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D015250:Aclarubicin / Q000008:administration & dosage; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002883:Chromosomes, Human, Pair 14; D003561:Cytarabine / Q000008:administration & dosage; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000188:drug therapy / Q000235:genetics; D007960:Leukocyte Disorders / Q000188:drug therapy / Q000235:genetics; D008297:Male; D009000:Monocytes; D011788:Quality of Life; D013922:Thrombocytosis / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D014314:Trisomy / Q000235:genetics / Q000473:pathology*
chemical_list: D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003561:Cytarabine; D015250:Aclarubicin; D006918:Hydroxyurea