Treatment with oxoglaucine can enhance host resistance to Candida albicans infection of mice with adjuvant arthritis.
The alkaloid oxoglaucine reduced CD4+ cell clones in adult mice and decreased CD4+, CD8+ and Ig+ levels in newborn mice. It prevented the increase of CD8+ and Ig+ clones induced by Candida albicans (C. albicans) in adult mice. TNF-alpha serum accumulation was inhibited by oxoglaucine in C. albicans infection and adjuvant arthritis. Treatment with oxoglaucine of arthritic mice, followed by inoculation with C. albicans enhanced the host resistance against the pathogen.
Ivanovska
N
N
Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. nina@microbio.bas.bg
Hristova
M
M
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives* / Q000276:immunology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000150:complications*; D001681:Biological Assay; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002176:Candida albicans / Q000187:drug effects*; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis
D000276:Adjuvants, Immunologic; D014409:Tumor Necrosis Factor-alpha; C111587:oxoglaucine; D001058:Apomorphine