title: Clinical rubella reinfection during pregnancy in a previously vaccinated woman.
abstract: We report a documented case of clinically apparent rubella reinfection during pregnancy with rubelliform rash and fever followed by lymphodenopathy at the 18th week of gestation, in a previously vaccinated woman with haemagglutination inhibition (HI) antibody titre of 1:32. The serological tests results (including neutralizing antibodies) demonstrated a significant rise in her rubella specific IgG level with strongly positive IgM reactivity. In addition, rubella-specific IgG antibody avidity testing displayed high avidity index (53-88%) typical of rubella reinfection. Umbilical cord blood, drawn by sonographic-guided cordocentesis at 24 weeks' gestation, was found to be negative for rubella-specific IgM antibody. The pregnancy was continued to term, and a healthy infant was born.
authors.affiliation: Central Virology Laboratory, Public Health Services, Ministry of Health and The Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Aboudy
authors.forename: B
authors.initials: B
authors.lastname: Barnea
authors.forename: L
authors.initials: L
authors.lastname: Yosef
authors.forename: T
authors.initials: T
authors.lastname: Frank
authors.forename: E
authors.initials: E
authors.lastname: Mendelson
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D011262:Pregnancy Trimester, Second; D012008:Recurrence; D012409:Rubella / Q000276:immunology*; D012411:Rubella Vaccine; D012412:Rubella virus / Q000276:immunology*; D012698:Serologic Tests
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012411:Rubella Vaccine