Environmental exposure to dioxin: the Seveso experience.
The toxicity in humans of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a man-made compound and environmental pollutant, is still debated. The industrial accident at Seveso, Italy, in 1976 exposed a large population of both sexes and of all ages to a massive concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Monitoring of soil and measurement of blood samples allowed classification of the exposed population into three categories: A, B and R (high, medium and low exposure, respectively). This article presents data from longitudinal health monitoring of the population, including liver function, immune function, neurological impairment, dermatological effects, reproductive pathology, and mortality.
Signorini
S
S
Department of Laboratory Medicine, University of Milano-Bicocca, Hospital of Desio, Italy.
Gerthoux
P M
PM
Dassi
C
C
Cazzaniga
M
M
Brambilla
P
P
Vincoli
N
N
Mocarelli
P
P
D000062:Accidents, Occupational; D000328:Adult; D002648:Child; D004702:Endocrine Glands / Q000187:drug effects; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007558:Italy; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008137:Longitudinal Studies; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009420:Nervous System / Q000187:drug effects / Q000503:physiopathology; D000072317:Polychlorinated Dibenzodioxins / Q000097:blood / Q000633:toxicity*; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D012867:Skin / Q000187:drug effects / Q000473:pathology
D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins