Clinical evidence for correlation of insufficient tissue oxygen supply (hypoxia) and tumor-associated proteolysis in squamous cell carcinoma of the head and neck.
Hypoxic tumors of patients with squamous cell carcinoma of the head and neck show a consistent trend towards poor treatment outcome. We now report that tumor hypoxia in these patients is correlated with elevated antigen content of the tumor-associated serine protease uPA (urokinase-type plasminogen activator), a marker of tumor cell invasion and metastasis.
Stadler
P
P
Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Germany. Peter.Stadler@Irz.tum.de
Feldmann
H J
HJ
Creighton
C
C
Zeilhoffer
H F
HF
Zimmermann
V
V
Schmitt
M
M
Molls
M
M
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis*
D014568:Urokinase-Type Plasminogen Activator