title: [Malformations of the central nervous system: analysis of 157 pediatric autopsies].
abstract: The malformations of the central nervous system affect about 5 to 10 children per 1000 births. We studied the central nervous system malformations in 5837 pediatric autopsies performed in the Sector of Anatomic Pathology, Hospital de Clínicas-UFPR, between 1960 and 1995. There were 157 central nervous system malformations (2.69%), the commonest were neural tube defects (61%): 47 cases of anencephaly and 45 cases classified in the group of myeloencephaloceles. The anomalies of the prosencephalic evagination corresponded to 8% of all central nervous system malformations, with seven cases of holoprosencephaly. Posterior fossa malformations occurred in 3%, with three cases of Arnold-Chiari. In the present study, the mortality rate due to central nervous system malformations was higher in the neonatal period.
authors.affiliation: Departamento de Patologia Médica, Universidade Federal do Paraná, Curitiba, Brasil. luno@uol.com.br
authors.forename: L
authors.initials: L
authors.lastname: De Noronha
authors.forename: F
authors.initials: F
authors.lastname: Medeiros
authors.forename: V D
authors.initials: VD
authors.lastname: Martins
authors.forename: G A
authors.initials: GA
authors.lastname: Sampaio
authors.forename: M J
authors.initials: MJ
authors.lastname: Serapião
authors.forename: G
authors.initials: G
authors.lastname: Kastin
authors.forename: L F
authors.initials: LF
authors.lastname: Torres
mesh_terms: D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D002490:Central Nervous System / Q000002:abnormalities* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005313:Fetal Death; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009421:Nervous System Malformations / Q000453:epidemiology; D009436:Neural Tube Defects / Q000453:epidemiology / Q000473:pathology; D017678:Sex Distribution