title: Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-S.
abstract: HPLC-NMR, HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified.
authors.affiliation: The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869-0602, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Segmuller
authors.forename: B L
authors.initials: BL
authors.lastname: Armstrong
authors.forename: R
authors.initials: R
authors.lastname: Dunphy
authors.forename: A R
authors.initials: AR
authors.lastname: Oyler
mesh_terms: D002851:Chromatography, High Pressure Liquid; D045166:Estradiol Congeners / Q000032:analysis* / Q000737:chemistry; D004997:Ethinyl Estradiol / Q000032:analysis* / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D045166:Estradiol Congeners; D007202:Indicators and Reagents; D004997:Ethinyl Estradiol