Evaluation of the half-life of intravenous human cytomegalovirus immune globulin in patients receiving partially mismatched related donor bone marrow transplantation.
OBJECTIVE
To evaluate the pharmacokinetics and use of intravenous human cytomegalovirus immune globulin (CytoGam) in allogeneic bone marrow transplantation (BMT).


METHODS
Prospective, nonrandomized, nonblinded, single-center study.


METHODS
University teaching hospital.


METHODS
Five consecutive patients with hematologic malignancies receiving partially mismatched related donor BMT with a uniform conditioning regimen including total body irradiation and chemotherapy.


METHODS
Serum immunoglobulin and cytomegalovirus (CMV) titers were measured before and 24 hours after the first CytoGam infusion on day -6 during the conditioning regimen.


RESULTS
These levels were measured every 5 days, and a second dose was administered when the CMV titer returned to 25-50% of the 24-hour level. The half-life of CytoGam was approximately 7 days.


CONCLUSIONS
We believe this is the first report of CytoGam's half-life in allogeneic BMT. The information may prove vital in a future study in which the agent's potential beneficial effects can be maximized.
DeRienzo
S Y
SY
Division of Transplantation Medicine, South Carolina Cancer Center, Palmetto Richland Memorial Hospital, University of South Carolina, Columbia 29203, USA.
Chiang
K Y
KY
O'Neal
W M
WM
Godder
K
K
Abhyankar
S
S
Christiansen
N P
NP
Bridges
K D
KD
Henslee-Downey
P J
PJ
D000328:Adult; D016026:Bone Marrow Transplantation; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000517:prevention & control; D005260:Female; D006207:Half-Life; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D014184:Transplantation, Homologous
D016756:Immunoglobulins, Intravenous