Invasion and distribution of methanol.
After the enzyme systems responsible for methanol oxidation were blocked by ethanol, five test persons were given methanol at a dose of approximately 10 mg/kg weight, once orally and once parenterally. Taking into account the endogenous blood methanol levels detectable before the administration of methanol, C0 concentrations of 11.1-15.9 mg/kg were reached. This corresponds to a distribution volume of approximately 0.77 +/- 0.07 l/kg, which is comparable to the 0.78 +/- 0.09 l/kg obtained for ethanol. After parenterally administering methanol as a bolus, the distribution half-life was on average 8 min (range: 3.8-13.8 min). After oral administration of methanol diluted in 100 ml water on an empty stomach, invasion took place with a half-life of approximately 5 min (3.8-6.9 min). In one case, however, due to vegetative disturbances the invasion half-life was 23.1 min.
Graw
M
M
Institute of Forensic Medicine, University of Tübingen, Germany. matthias.graw@gmx.de
Haffner
H T
HT
Althaus
L
L
Besserer
K
K
Voges
S
S
D000284:Administration, Oral; D000328:Adult; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D000432:Methanol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000431:Ethanol; D000432:Methanol