In vivo uptake of azithromycin in human coronary plaques.
Ten patients with symptomatic coronary artery disease received oral azithromycin for 3 days and underwent directional atherectomy on the third day. Azithromycin was found in all plaque samples with a median concentration of 284 ng/ml (95% confidence interval 163 to 517 ng/ml).
Schneider
C A
CA
Klinik III für Innere Medizin, Universität zu Köln, Germany. christian.schneider@medizin.uni-koeln.de
Diedrichs
H
H
Riedel
K D
KD
Zimmermann
T
T
Höpp
H W
HW
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017225:Atherectomy, Coronary; D017963:Azithromycin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016022:Case-Control Studies; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification; D003327:Coronary Disease / Q000378:metabolism* / Q000382:microbiology / Q000628:therapy; D006801:Humans; D011446:Prospective Studies
D000900:Anti-Bacterial Agents; D017963:Azithromycin