Carbohydrate-modulated DNA photocleavage: design, synthesis, and evaluation of novel glycosyl anthraquinones.
Novel and artificial anthraquinone-carbohydrate hybrids were designed and synthesized, and found to effectively cleave DNA under irradiation with a long wavelength UV light and also exhibit cytotoxicity against HeLa S3 cells.
Toshima
K
K
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan. toshima@applc.keio.ac.jp
Maeda
Y
Y
Ouchi
H
H
Asai
A
A
Matsumura
S
S
D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D007364:Intercalating Agents / Q000378:metabolism; D015394:Molecular Structure; D010782:Photolysis / Q000187:drug effects*; D014466:Ultraviolet Rays
D000880:Anthraquinones; D002241:Carbohydrates; D007364:Intercalating Agents; D004247:DNA