title: Emergency implantation of a left ventricular assist device in adolescents with biventricular failure.
abstract: Adolescents with congestive cardiomyopathy who present with intractable arrhythmia or progressive ventricular failure have a very poor prognosis and often die awaiting cardiac transplantation (CTx). We present our recent experience with a pneumatically powered left ventricular assist device (LVAD) implanted emergently to salvage adolescents with severe biventricular failure. Four patients, aged 15-17 years, body surface areas of 1.5-1.7 m2, with dilated cardiomyopathy (LV diastolic dimension, 7.1-8.3 cm); two presented with cardiovascular collapse, one with refractory ventricular tachycardia, and one with cardiac arrest. Hemodynamic and biochemical data before and 1 week after LVAD placement are expressed as mean and range values. None of the patients required right ventricular assist, and all patients achieved functional recovery while on LVAD support (8-71 days). Currently, all four patients are alive (11-22 months) after successful CTx. We conclude that emergency implantation of an LVAD in adolescents with biventricular heart failure can be life saving. As has been shown in the adult population, such a ventricular assist system restores normal circulatory hemodynamics, reverses multi-organ dysfunction, and provides a "safe" bridge to transplantation.
authors.affiliation: Division of Cardiothoracic Surgery, Loma Linda University Medical Center, California 92354, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Razzouk
authors.forename: R
authors.initials: R
authors.lastname: Cecere
authors.forename: S R
authors.initials: SR
authors.lastname: Gundry
authors.forename: N
authors.initials: N
authors.lastname: Wang
authors.forename: L L
authors.initials: LL
authors.lastname: Bailey
mesh_terms: D000293:Adolescent; D004630:Emergencies; D006333:Heart Failure / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male