Transduction of the discriminative stimulus effects of zolpidem by GABA(A)/alpha1 receptors.
Zolpidem is an imidazopyridine with high affinity at gamma-aminobutyric acid(A) (GABA(A)) receptors expressing alpha1 subunits. In squirrel monkeys trained to discriminate a high dose of zolpidem (> or =3.0 mg/kg) from saline, zolpidem and another GABA(A)/alpha1 receptor-preferring agonist, zaleplon, substituted dose-dependently for zolpidem, whereas the non-selective agonists diazepam and triazolam were did not substitute at any dose tested. These findings offer the first evidence for a selective role of GABA(A)/alpha1 receptors in the interoceptive effects of high doses of zolpidem.
Rowlett
J K
JK
New England Regional Primate Research Center, Harvard Medical School, Box 9102, One Pine Hill Drive, Southborough, MA, USA. james_rowlett@hms.harvard.edu
Lelas
S
S
Spealman
R D
RD
D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004192:Discrimination, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D018755:GABA Agonists / Q000494:pharmacology*; D018757:GABA Modulators / Q000494:pharmacology; D058785:GABA-A Receptor Agonists; D008297:Male; D021122:Protein Subunits; D011725:Pyridines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology; D012055:Reinforcement Schedule; D012453:Saimiri; D014229:Triazolam / Q000494:pharmacology; D000077334:Zolpidem
D000081:Acetamides; D018755:GABA Agonists; D018757:GABA Modulators; D058785:GABA-A Receptor Agonists; D021122:Protein Subunits; D011725:Pyridines; D011743:Pyrimidines; D014229:Triazolam; D000077334:Zolpidem; D003975:Diazepam; C085665:zaleplon