Identification of autoxidation and photodegradation products of ethynylestradiol by on-line HPLC-NMR and HPLC-S.
HPLC-NMR, HPLC-MS, and HPLC-UV were used to characterize the predominant solution autoxidation and photodegradation products of ethynylestradiol (1). A hydroperoxide (2) and a series of isomeric dimeric oxidation products (3-7), were identified.
Segmuller
B E
BE
The R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869-0602, USA.
Armstrong
B L
BL
Dunphy
R
R
Oyler
A R
AR
D002851:Chromatography, High Pressure Liquid; D045166:Estradiol Congeners / Q000032:analysis* / Q000737:chemistry; D004997:Ethinyl Estradiol / Q000032:analysis* / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010777:Photochemistry; D013056:Spectrophotometry, Ultraviolet
D045166:Estradiol Congeners; D007202:Indicators and Reagents; D004997:Ethinyl Estradiol