Preliminary studies on the analgesic activity of latex of Calotropris procera.
In this study we have evaluated the analgesic activity of dry latex (DL) of Calotropis procera. A single oral dose of DL ranging from 165 to 830 mg/kg produced a significant dose dependent analgesic effect against acetic acid induced writhings. The effect of DL at a dose of 415 mg/kg was more pronounced as compared to a 100 mg/kg oral dose of aspirin. On the other hand DL (830 mg/kg) produced marginal analgesia in a tail-flick model which was comparable to aspirin. The analgesic effect of DL was delayed by 1 h by naloxone at a dose of 0. 5 mg/kg, i.p., which completely blocked the analgesic effect of morphine (10 mg/kg, i.p.). However, the effect of aspirin was not blocked by naloxone. The 830 mg/kg oral dose of DL did not produce toxic effects in mice and the LD(50) was found to be 3 g/kg.
Dewan
S
S
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India.
Sangraula
H
H
Kumar
V L
VL
D019342:Acetic Acid / Q000037:antagonists & inhibitors; D000700:Analgesics / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001241:Aspirin / Q000627:therapeutic use; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D007840:Latex / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use* / Q000633:toxicity; D010946:Plants, Medicinal
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007840:Latex; D009292:Narcotic Antagonists; D010936:Plant Extracts; D009270:Naloxone; D009020:Morphine; D019342:Acetic Acid; D001241:Aspirin