[Malformations of the central nervous system: analysis of 157 pediatric autopsies].
The malformations of the central nervous system affect about 5 to 10 children per 1000 births. We studied the central nervous system malformations in 5837 pediatric autopsies performed in the Sector of Anatomic Pathology, Hospital de Clínicas-UFPR, between 1960 and 1995. There were 157 central nervous system malformations (2.69%), the commonest were neural tube defects (61%): 47 cases of anencephaly and 45 cases classified in the group of myeloencephaloceles. The anomalies of the prosencephalic evagination corresponded to 8% of all central nervous system malformations, with seven cases of holoprosencephaly. Posterior fossa malformations occurred in 3%, with three cases of Arnold-Chiari. In the present study, the mortality rate due to central nervous system malformations was higher in the neonatal period.
De Noronha
L
L
Departamento de Patologia Médica, Universidade Federal do Paraná, Curitiba, Brasil. luno@uol.com.br
Medeiros
F
F
Martins
V D
VD
Sampaio
G A
GA
Serapião
M J
MJ
Kastin
G
G
Torres
L F
LF
D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D002490:Central Nervous System / Q000002:abnormalities* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005313:Fetal Death; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009421:Nervous System Malformations / Q000453:epidemiology; D009436:Neural Tube Defects / Q000453:epidemiology / Q000473:pathology; D017678:Sex Distribution