title: Implantation of one piece biventricular assist device by left thoracotomy in an ovine model.
abstract: In this report, we describe an operative procedure for our implantable 1 piece biventricular assist device (BiVAD) based on a moving actuator mechanism, using an ovine model. Our implantable BiVAD is a volumetric coupled 1 piece unit including right and left blood sacs and an actuator assembly based on the moving actuator mechanism. The BiVAD was controlled by fixed rate control with 75 bpm for the most part. Both the left and the right full ejection modes with the maximum stroke angle were selected to minimize blood stasis in the blood sacs because of low assist flow condition. Three Corriedale sheep were used for the device implantation by a left thoracotomy incision. Cannulation was successfully performed in all cases. Although exposability of the right atrial appendage varied from animal to animal, the insertion of the cannula was easily performed. The cannulas were connected to the pump-actuator assembly in the preperitoneal pocket. All 3 animals survived the experimental procedure. During implantation of the device, in the 1 month survival animal, pump flow was maintained between 2.0 L/min and 2.5 L/min, mean aortic pressure was 90-110 mm Hg, and mean pulmonary artery pressure was 20-30 mm Hg. The left and right atrial pressure were maintained between 0 and 5 mm Hg. In conclusion, this ovine model for implantation of the 1 piece BiVAD can be an effective alternative for testing in vivo biocompatibility of the device although it needs more consideration for anatomical fittability for future human application.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery and Heart Research Institute, Seoul National University College of Medicine and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea. wongon@plaza.snu.ac.kr
authors.forename: W G
authors.initials: WG
authors.lastname: Kim
authors.forename: Y H
authors.initials: YH
authors.lastname: Jo
authors.forename: B G
authors.initials: BG
authors.lastname: Min
authors.forename: T H
authors.initials: TH
authors.lastname: Won
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology; D016275:Atrial Function; D001672:Biocompatible Materials; D001794:Blood Pressure / Q000502:physiology; D006328:Cardiac Catheterization / Q000295:instrumentation; D002302:Cardiac Output / Q000502:physiology; D004195:Disease Models, Animal; D004867:Equipment Design; D006325:Heart Atria / Q000601:surgery; D006339:Heart Rate / Q000502:physiology; D006353:Heart-Assist Devices; D006801:Humans; D010537:Peritoneum / Q000601:surgery; D011651:Pulmonary Artery / Q000502:physiology; D012756:Sheep; D013318:Stroke Volume / Q000502:physiology; D015996:Survival Rate; D013908:Thoracotomy / Q000379:methods*
chemical_list: D001672:Biocompatible Materials