Synthesis and antiproliferative evaluation of 7-aminosubstituted pyrroloiminoquinone derivatives.
Coupling of five amines on the 7-methoxy-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline core was achieved and afforded, in particular, an opened analogue of the natural alkaloid wakayin. Evaluation of cytotoxic activity of compounds 2, 10-13 on L1210 cells afforded IC50 in the range 0.25 5.3 microM.
Bénéteau
V
V
Laboratoire de Génie Protéique et Cellulaire, UPRES 2001, Pôle Sciences et Technologie, Université de La Rochelle, France.
Pierré
A
A
Pfeiffer
B
B
Renard
P
P
Besson
T
T
D000470:Alkaloids / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007939:Leukemia L1210; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000970:Antineoplastic Agents; D011758:Pyrroles; D015363:Quinolones