Quantitative trait loci affecting prion incubation time in mice.
Although the gene encoding prion protein (PrP) is the major determinant of susceptibility to prion disease, other genes also affect prion incubation time in mice and may be involved in prion replication. Scrapie incubation time was analyzed as a quantitative trait using crosses between SJL/J and CAST/Ei mice; these mouse strains encode identical PrP molecules but have different incubation periods. Our analysis revealed loci on Chromosomes 9 and 11 that affect prion susceptibility.
Stephenson
D A
DA
McLaughlin Research Institute, Great Falls, Montana 59405, USA.
Chiotti
K
K
Ebeling
C
C
Groth
D
D
DeArmond
S J
SJ
Prusiner
S B
SB
Carlson
G A
GA
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D016678:Genome; D008126:Lod Score; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018895:Microsatellite Repeats; D018620:PrPSc Proteins / Q000235:genetics*; D017096:Prion Diseases / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012608:Scrapie / Q000235:genetics; D013045:Species Specificity; D013997:Time Factors
D018620:PrPSc Proteins