Expression of the follistatin/EGF-containing transmembrane protein M7365 (tomoregulin-1) during mouse development.
A novel transmembrane protein (designated X7365) containing two follistatin modules and an epidermal growth factor (EGF) domain has been described in the hypothalamic-pituitary axis of Xenopus laevis. We have now cloned the highly conserved mouse orthologue (M7365), and its mRNA was detected in many mesodermal and (neuro)ectodermal tissues in 8.5-day-old mouse embryos. During further development, M7365 mRNA expression became restricted to certain regions in the brain and to ganglia. In the adult mouse, the brain is the major site of M7365 expression.
Eib
D W
DW
Department of Animal Physiology, University of Nijmegen, Toernooiveld 1, 6525 ED, The, Nijmegen, Netherlands.
Holling
T M
TM
Zwijsen
A
A
Dewulf
N
N
de Groot
E
E
van den Eijnden-van Raaij
A J
AJ
Huylebroeck
D
D
Martens
G J
GJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology / Q000378:metabolism; D018076:DNA, Complementary; D005314:Embryonic and Fetal Development; D004815:Epidermal Growth Factor / Q000235:genetics*; D038681:Follistatin; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger; D017386:Sequence Homology, Amino Acid; D029867:Xenopus Proteins; D014982:Xenopus laevis
D018076:DNA, Complementary; D038681:Follistatin; D006023:Glycoproteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; C101124:TMEFF1 protein, Xenopus; C423567:TMEFF2 protein, human; C486585:Tmeff1 protein, mouse; D029867:Xenopus Proteins; D004815:Epidermal Growth Factor