title: Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives.
abstract: In the search for new molluscicidal agents we tested the activity of lapachol and other 2-hydroxy-3-alkylnaphthoquinones possessing nitrogenated alkyl chains, against the snail Biomphalaria glabrata. Lapachol, isolapachol and nor-lapachol showed strong molluscicidal activity against the adult snail (LD(90)<10 ppm) and significant toxicity against snail egg masses (LD(90)<0.2 ppm). As lapachol is easily extracted, and the derivatives can be synthesised without any difficulty, large-scale synthesis and field tests can be conducted, with a view to large-scale molluscicidal programs.
authors.affiliation: Departamento de Química/CCEN, Universidade Federal de Alagoas, Maceió, Alagoas, 57072-970, Brazil.
authors.forename: A F
authors.initials: AF
authors.lastname: dos Santos
authors.forename: P A
authors.initials: PA
authors.lastname: Ferraz
authors.forename: A V
authors.initials: AV
authors.lastname: Pinto
authors.forename: C
authors.initials: C
authors.lastname: Pinto M do
authors.forename: M O
authors.initials: MO
authors.lastname: Goulart
authors.forename: A E
authors.initials: AE
authors.lastname: Sant'Ana
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001681:Biological Assay; D001938:Brazil; D008975:Molluscacides / Q000494:pharmacology*; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects / Q000254:growth & development*
chemical_list: D000890:Anti-Infective Agents; D008975:Molluscacides; D009285:Naphthoquinones; C008252:lapachol