title: Medical treatment of a pacemaker endocarditis due to Candida albicans and to Candida glabrata.
abstract: We describe a case of pacemaker infection due to two fungal species: Candida albicans and C. glabrata. Transthoracic echocardiography showed a large vegetation on the intraventricular wires. Because of severe underlying diseases, surgery was believed to be contraindicated. The patient was treated using high dose of fluconazole, resulting in clinical improvement and negative blood cultures. However, 2 months later, the patient underwent a fatal stroke. At autopsy, a large vegetation was found only all along the wires. Postmortem culture of the infected material was positive for both C. albicans and C. glabrata.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Hôpital de l'Archet, Route St Antoine de Ginestière, BP79, 06202 Nice, France.
authors.forename: P M
authors.initials: PM
authors.lastname: Roger
authors.forename: C
authors.initials: C
authors.lastname: Boissy
authors.forename: M
authors.initials: M
authors.lastname: Gari-Toussaint
authors.forename: R
authors.initials: R
authors.lastname: Foucher
authors.forename: V
authors.initials: V
authors.lastname: Mondain
authors.forename: F
authors.initials: F
authors.lastname: Vandenbos
authors.forename: Y
authors.initials: Y
authors.lastname: le Fichoux
authors.forename: J F
authors.initials: JF
authors.lastname: Michiels
authors.forename: P
authors.initials: P
authors.lastname: Dellamonica
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000302:isolation & purification; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology; D017809:Fatal Outcome; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole