Octreotide prevents postoperative adhesion formation by suppressing peritoneal myeloperoxidase activity.
OBJECTIVE
Despite a great deal of effort to prevent the adhesion formation, an ideal therapy or drug remains to be identified. The aim of this study was to investigate the effect of octreotide on adhesion prevention and neutrophil infiltration.


METHODS
Fourteen female Sprague-Dawley rats were subjected to a standard intraabdominal adhesion model operation. Octreotide group (n = 7) rats were administered 20 micrograms/kg octreotide intramuscular while control group (n = 7) rats were given no treatment. On the 10th day the rats were decapitated and the degrees of adhesions were recorded and the plasma, peritoneal fluid, peritoneal tissue myeloperoxidase levels were determined.


RESULTS
Intraabdominal adhesions and peritoneal tissue myeloperoxidase levels were significantly reduced in the octreotide group as compared to saline treated adhesion group.


CONCLUSIONS
We concluded that octreotide reduces the intraabdominal adhesions. This adhesion-preventive effect may be due to the inhibition of neutrophil infiltration.
Alatas
E
E
Department of Gynecology, Pamukkale University, Turkey.
Günal
O
O
Alatas
O
O
Colak
O
O
D000818:Animals; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D015282:Octreotide / Q000494:pharmacology*; D010537:Peritoneum / Q000201:enzymology* / Q000601:surgery; D009195:Peroxidase / Q000037:antagonists & inhibitors*; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D000267:Tissue Adhesions / Q000517:prevention & control*
D005765:Gastrointestinal Agents; D009195:Peroxidase; D015282:Octreotide