[Platelet aggregation in patients with hypertrophic cardiomyopathy].
OBJECTIVE
To examine correlation between platelet aggregation and the degree of left ventricular hypertrophy (LVH) in patients with hypertrophic cardiomyopathy (HC).


METHODS
Routine clinical examination, ECG, echo-CG, measurement of platelet aggregation, routine biochemical blood tests were made in 45 HC males and 15 healthy controls.


RESULTS
HC patients were characterized with high induced and spontaneous platelet aggregation which increased with left ventricular myocardial mass. In LVH, platelets were especially sensitive to the aggregation inductor U-46619, thromboxane A2 analogue.


CONCLUSIONS
It is demonstrated that there is a positive correlation between platelet aggregation and the degree of LVH in HC patients.
Riazanov
A S
AS
Gabbasov
Z A
ZA
Iurenev
A P
AP
D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000502:physiology*; D012720:Severity of Illness Index