title: Liver resistance to toxic effects of CCl(4) under conditions of gadolinium chloride depression of Kupffer cells.
abstract: Acute toxic hepatitis was modeled in (CBAxC57B1)F1 mice by single injection of 40% CCl(4) in oil. Pretreatment with gadolinium chloride, a selective blocker of Kupffer cells, considerably potentiated damage to hepatocytes leading to generalization of this process, delayed inflammatory infiltration, and inhibited reparative processes. Zymosan administered against the background of gadolinium chloride blockade improved liver resistance to CCl(4)-induced damage, intensified mononuclear infiltration, and accelerated reparative processes.
authors.affiliation: Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: D D
authors.initials: DD
authors.lastname: Cyrendorzhiev
authors.forename: S N
authors.initials: SN
authors.lastname: Kutina
authors.forename: A A
authors.initials: AA
authors.lastname: Zubakhin
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D005682:Gadolinium / Q000494:pharmacology*; D007728:Kupffer Cells / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors; D015054:Zymosan / Q000494:pharmacology
chemical_list: D015054:Zymosan; D005682:Gadolinium; D002251:Carbon Tetrachloride; C038958:gadolinium chloride