title: Cyanocobalamin absorption abnormality in alcoholics is improved by oral supplementation with a fermented papaya-derived antioxidant.
abstract: OBJECTIVE
  Thirty alcoholic patients and 24 teetotaler dyspeptic patients were considered and underwent baseline blood chemical evaluation and the Schilling test.
  
  
  METHODS
  During gastroscopy, biopsy samples were taken to assay: routine histology, malonyldialdehyde, vitamin E and glutathione concentration and for testing vitamin B12-Intrinsic Factor binding. Examinations were repeated after 1-week supplementation with Bionormalizer.
  
  
  RESULTS
  Plasma malonyldialdehyde level and lipid hydroperoxides concentration as well as either malonyldialdehyde and xanthine oxidase concentration in the gastric mucosa in alcoholics were significantly higher than in controls and despite unchanged alcohol consumption, significantly decreased after Bionormalizer supplementation. Gastric mucosal glutathione was markedly depressed in alcoholics and partly recovered after Bionormalizer supplementation. Although the alcoholics showed a normal intrinsic factor secretion in the gastric juice, they exhibited a markedly depressed intrinsic factor-cobalamin binding on the "ex vivo" study. Moreover, nearly 23% of them had an abnormal Schilling test. Both these impairments reverted to normal after Bio-normalizer supplementation.
  
  
  CONCLUSIONS
  It can be postulated that the antioxidative action played by Bionormalizer, possibly due to its availability substrates for glutathione synthesis as well as to its effects on local oxidative burst from neutrophil, is able to recover a normal cobalamin absorption.
authors.affiliation: Hepatogastroenterology Dept., S. Giuseppe Hospital, Milano, Italy. fmarchimede@libero.it
authors.forename: F
authors.initials: F
authors.lastname: Marotta
authors.forename: H
authors.initials: H
authors.lastname: Tajiri
authors.forename: R
authors.initials: R
authors.lastname: Barreto
authors.forename: P
authors.initials: P
authors.lastname: Brasca
authors.forename: G M
authors.initials: GM
authors.lastname: Idéo
authors.forename: L
authors.initials: L
authors.lastname: Mondazzi
authors.forename: P
authors.initials: P
authors.lastname: Safran
authors.forename: J
authors.initials: J
authors.lastname: Bobadilla
authors.forename: G
authors.initials: G
authors.lastname: Idéo
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000437:Alcoholism / Q000378:metabolism*; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D001774:Blood Chemical Analysis; D016022:Case-Control Studies; D019587:Dietary Supplements; D004415:Dyspepsia / Q000378:metabolism; D005260:Female; D005285:Fermentation; D005750:Gastric Juice / Q000737:chemistry; D005753:Gastric Mucosa / Q000378:metabolism*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D012546:Schilling Test; D018709:Statistics, Nonparametric; D014805:Vitamin B 12 / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D014805:Vitamin B 12