In vitro measurement of the frequency-dependent attenuation in cancellous bone between 0.2 and 2 MHz.
Our goal was to evaluate the frequency dependence of the ultrasonic attenuation coefficient in cancellous bone. Estimates were obtained in immersion, using a substitution method in the through-transmit mode, by scanning 14 human bone specimens (calcaneus). Measurements were performed with three pairs of focused transducers with a center frequency of 0.5, 1.0, and 2.25 MHz, respectively in order to cover an extended frequency bandwidth (0.2-1.7 MHz). When the experimental attenuation coefficient values were modeled with a nonlinear power fit alpha(f)=alpha0 +alpha(I)f(n), the attenuation coefficient was found to increase as f(1.09+/-0.3) over the measurement bandwidth. However, a substantial variation of the exponent n (0.4-2.2) within specimens and also between specimens was observed. The acoustical parameters were compared to bone mineral density. A highly significant relationship was noted between alpha1 and BMD (r2= 0.75, p< 10(-4)). No correlation was found between n and BMD. Several attenuation mechanisms are discussed as well as the potential impact these results may have in in vivo quantitative measurements.
Chaffaï
S
S
Laboratoire d'Imagerie Paramétrique UMR CNRS 7623, Université Pierre et Marie Curie, Paris, France.
Padilla
F
F
Berger
G
G
Laugier
P
P
D000162:Acoustics; D000368:Aged; D000369:Aged, 80 and over; D002111:Calcaneus / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D014463:Ultrasonography