title: Methadone detoxification of tramadol dependence.
abstract: Tramadol hydrochloride is a centrally acting analgesic with a partial affinity for the opiate receptor (mu), having an analgesic potency estimated to be one tenth that of morphine. While preclinical investigations suggested that abuse liability associated with tramadol use is low, there are increasing numbers of cases reported to the U.S. Food and Drug Administration of abuse, dependence, and withdrawal associated with tramadol use. A case of a patient with tramadol dependence requiring detoxification with methadone is presented. Acute management of significant tramadol dependence has not yet been reported in the literature. Long-term treatment issues are also discussed.
authors.affiliation: Department of Psychiatry, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Erie County Medical Center, 462 Grider Street, Buffalo, NY 14215, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Leo
authors.forename: R
authors.initials: R
authors.lastname: Narendran
authors.forename: B
authors.initials: B
authors.lastname: DeGuiseppe
mesh_terms: D000208:Acute Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000523:psychology / Q000534:rehabilitation*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000534:rehabilitation; D014147:Tramadol / Q000009:adverse effects
chemical_list: D014147:Tramadol; D008691:Methadone