title: Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines.
abstract: Novel 6-cyanoindolo[3,2-c]quinoline and 6-cyanobenzimidazo[1,2-c]quinazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4.5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt). The cytotoxicity and the effect of these compounds on cellular growth were measured.
authors.affiliation: Laboratoire de Génie Protéique et Cellulaire, UPRES 2001, Groupe de Chimie Organique, Pôle Sciences et Technologie, Université de La Rochelle, France.
authors.forename: C
authors.initials: C
authors.lastname: Lamazzi
authors.forename: S
authors.initials: S
authors.lastname: Léonce
authors.forename: B
authors.initials: B
authors.lastname: Pfeiffer
authors.forename: P
authors.initials: P
authors.lastname: Renard
authors.forename: G
authors.initials: G
authors.lastname: Guillaumet
authors.forename: C W
authors.initials: CW
authors.lastname: Rees
authors.forename: T
authors.initials: T
authors.lastname: Besson
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D019073:HT29 Cells; D006801:Humans; D007939:Leukemia L1210; D051379:Mice; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D011799:Quinazolines; D011804:Quinolines