title: Gel-derived materials of a CaO-P(2)O(5)-SiO(2) system modified by boron, sodium, magnesium, aluminum, and fluorine compounds.
abstract: Bioactive glass-ceramic materials of the CaO-P(2)O(5)-SiO(2) system modified by adding boron, magnesium, sodium, fluorine, and aluminum were obtained using the sol-gel method. Gel-derived materials were produced in the pellet form obtained by compression of powders as well as in coatings on glass slides. The materials obtained were examined in vitro with regard to the ability of calcium phosphate layer to form on the material surface as the result of contact with simulated body fluid (SBF). SBF pH changes and calcium solubility in this solution were determined and scanning electron microscopy, energy-dispersive X-ray analysis, and infrared spectroscopy studies were conducted before and after contact of the materials with SBF. The gels modified by aluminum were amorphous, whereas the sodium and fluorine additives promoted the bulk crystallization of gel-derived materials. The ability of calcium phosphates to crystallize on the surface of gel-derived materials depended only slightly on the types of additives applied, and the character of this dependence was different from that observed in melted glasses. Moreover, to estimate the biocompatibility of gel-derived coatings, we examined the proliferation, collagen synthesis, adhesion, and morphology of fibroblasts (NRK cells) cultured in the presence of gel-derived materials. The results of these experiments showed that none of the tested materials significantly reduced any cell function.
authors.affiliation: University of Mining and Metallurgy, Faculty of Material Science and Ceramics, Krakow, Al. Mickiewicza 30, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Laczka
authors.forename: K
authors.initials: K
authors.lastname: Cholewa-Kowalska
authors.forename: A
authors.initials: A
authors.lastname: Laczka-Osyczka
authors.forename: M
authors.initials: M
authors.lastname: Tworzydlo
authors.forename: B
authors.initials: B
authors.lastname: Turyna
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001826:Body Fluids; D048429:Cell Size; D002516:Ceramics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003460:Crystallization; D017886:Durapatite / Q000737:chemistry; D004577:Electron Probe Microanalysis; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005782:Gels; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D008854:Microscopy, Electron; D016062:Porosity; D011208:Powders; D051381:Rats; D019279:Resin Cements / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012996:Solutions; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; C116882:CaO-SiO2-P2O5-CaF2 glass; D005782:Gels; D011208:Powders; D019279:Resin Cements; D012996:Solutions; C416205:calcium oxide-silicon dioxide-diphosphorus pentoxide glass; C120461:sodium oxide-calcium oxide-silicon dioxide-diphosphorus pentoxide; D017886:Durapatite