title: Carbohydrate-modulated DNA photocleavage: design, synthesis, and evaluation of novel glycosyl anthraquinones.
abstract: Novel and artificial anthraquinone-carbohydrate hybrids were designed and synthesized, and found to effectively cleave DNA under irradiation with a long wavelength UV light and also exhibit cytotoxicity against HeLa S3 cells.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan. toshima@applc.keio.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Toshima
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Ouchi
authors.forename: A
authors.initials: A
authors.lastname: Asai
authors.forename: S
authors.initials: S
authors.lastname: Matsumura
mesh_terms: D000880:Anthraquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D007364:Intercalating Agents / Q000378:metabolism; D015394:Molecular Structure; D010782:Photolysis / Q000187:drug effects*; D014466:Ultraviolet Rays
chemical_list: D000880:Anthraquinones; D002241:Carbohydrates; D007364:Intercalating Agents; D004247:DNA