title: Expression of beta1 integrin in relation to histological features in normal and neoplastic canine testicles.
abstract: The expression of the beta1 common chain of the VLA integrin subfamily was evaluated immunohistochemically in a series of five normal and 30 neoplastic canine testicles. The tumours, consisting of seminomas or Sertoli cell tumours, were classified according to WHO criteria as intraductal without signs of invasion, intraductal with signs of invasion, or diffuse. Expression of beta1 integrin decreased progressively from intraductal tumours without signs of invasion, to the diffuse type, in which immunolabelling was generally absent. In a few cases of diffuse neoplasia, groups of neoplastic cells exhibited strong positivity that was not restricted to the basal pole of the cell membrane. These results suggest that the expression of beta1 integrin was related to the histological tumour type, possibly reflecting a specific requirement for a reduction in integrin by neoplastic cells with infiltrative and metastatic potential.
authors.affiliation: Dipartimento di Patologia e Sanità Animale-Settore Anatomia Patologica Facoltà di Medicina Veterinaria, Università "Federico II", Naples, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Restucci
authors.forename: P
authors.initials: P
authors.lastname: Maiolino
authors.forename: S
authors.initials: S
authors.lastname: Papparella
authors.forename: G
authors.initials: G
authors.lastname: De Vico
mesh_terms: D000818:Animals; D004285:Dogs; D007150:Immunohistochemistry; D019012:Integrin beta1 / Q000096:biosynthesis*; D008297:Male; D009361:Neoplasm Invasiveness; D018239:Seminoma / Q000378:metabolism / Q000473:pathology; D012707:Sertoli Cell Tumor / Q000378:metabolism / Q000473:pathology; D013736:Testicular Neoplasms / Q000378:metabolism* / Q000473:pathology; D013737:Testis / Q000033:anatomy & histology / Q000737:chemistry*
chemical_list: D019012:Integrin beta1