Zinc fingers: DNA binding and protein-protein interactions.
The zinc finger domain is a very ubiquitous structural element whose hallmark is the coordination of a zinc atom by several amino acid residues (cysteines and histidines, and occasionally aspartate and glutamate). These structural elements are associated with protein-nucleic acid recognition as well as protein-protein interactions. The purpose of this review is to examine recent data on the DNA and protein binding properties of a few zinc fingers whose three dimensional structure is known.
Leon
O
O
Instituto de Bioquímica, Universidad Austral de Chile, Valdivia, Chile. oleon@uach.cl
Roth
M
M
D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D016335:Zinc Fingers / Q000502:physiology*
D004268:DNA-Binding Proteins