Fluconazole-induced convulsions at serum trough concentrations of approximately 80 microg/mL.
On the basis of two case reports it is suggested that serious convulsions may occur in patients treated with flucoazole when serum trough concentrations exceed 80 microg/mL. The authors recommend monitoring fluconazole concentrations during high-dose therapy in patients with poor kidney function.
Matsumoto
K
K
Department of Pharmacy, National Cardiovascular Center, Suita-city, Osaka, Japan.
Ueno
K
K
Yoshimura
H
H
Morii
M
M
Takada
M
M
Sawai
T
T
Mitsutake
K
K
Shibakawa
M
M
D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D002177:Candidiasis / Q000188:drug therapy; D004334:Drug Administration Schedule; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced*; D013530:Surgical Wound Infection / Q000188:drug therapy
D000935:Antifungal Agents; D015725:Fluconazole