title: P300 event-related brain potential and personality in depression.
abstract: P300 is an event-related brain potential (ERP) particularly interesting to the study of cognitive processes in normal subjects and in psychopathology. P300 has been applied in depression with controversial results. A major source for these controversial results could result from the diversity of depressed patients included in the different studies. Supporting this assumption, impulsivity, blunted affect, suicidal behavior and psychotic features significantly influence P300 amplitude. However, no data are available on the possible influences of the personality of depressed patients on P300. Since personality is related to P300 in normal subjects, the aim of the present study is to investigate the relationship between ERPs (P200, N200, and P300) and the Temperament and Character Inventory (TCI) in 54 depressed patients. The main results of the study concern the absence of major correlations between personality dimensions as assessed by the TCI and ERP parameters among depressed patients. Only weak partial positive correlations relate N200 latency with harm avoidance, and P300 amplitude (Pz) with the self-directedness dimension. N200 amplitude is also negatively correlated to persistence. However, the preliminary nature of the presented results with respect to the weak statistical significance should be underlined.
authors.affiliation: Department of Psychiatry, Centre Hospitalier Universitaire du Sart Tilman (B-35), B-4000 Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Hansenne
authors.forename: W
authors.initials: W
authors.lastname: Pitchot
authors.forename: E
authors.initials: E
authors.lastname: Pinto
authors.forename: J
authors.initials: J
authors.lastname: Reggers
authors.forename: P
authors.initials: P
authors.lastname: Papart
authors.forename: M
authors.initials: M
authors.lastname: Ansseau
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000175:diagnosis*; D003863:Depression / Q000150:complications*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000150:complications* / Q000175:diagnosis* / Q000523:psychology; D010555:Personality Inventory