title: Restoration of fusion in children with intracranial tumors and incomitant strabismus.
abstract: OBJECTIVE
  Intracranial tumors may cause eye misalignment and interruption of sensory fusion. The ocular misalignment may be permanent or may be corrected after tumor treatment with or without specific strabismus treatment. This report analyzes the binocular vision outcome of children with misaligned eyes from brain tumors who regain orthotropia.
  
  
  METHODS
  A retrospective noncomparative case series.
  
  
  METHODS
  Twenty-three surviving children less than 18 years of age with a new heterotropia and absence of fusion associated with the development of a brain tumor.
  
  
  METHODS
  Tumor resection/radiation/chemotherapy and necessary strabismus management.
  
  
  METHODS
  Stereopsis (>/= 4 of 10 circles) measured with the Randot II stereo test at near fixation.
  
  
  RESULTS
  Fourteen children regained orthotropia either after tumor therapy, strabismus treatment, or both. Ten of these 14 children with realigned vision regained high-grade stereovision. Nine patients did not regain orthotropia and were excluded. The mean age at tumor diagnosis of the fusing group was 9.9 years (range, 3-17 years) compared with 8.5 years (range, 6-12 years) in the four realigned nonfusing patients. The mean duration of misalignment was 12 months (range, 2-51 months) for the fusing group, and 45 months (range, 14-120 months) for the nonfusing group.
  
  
  CONCLUSIONS
  Children and adolescents with brain tumor-associated eye misalignment may regain the ability to fuse if their misalignment can be corrected. An improved prognosis was noted for those patients when the misalignment had been present for a shorter duration. These data suggest that the outcome may be better for incomitant strabismus than that reported for acute comitant esotropia.
authors.affiliation: Zanvyl Krieger Children's Eye Center, Wilmer Ophthalmological Institute, and the Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-9028, USA.
authors.forename: B
authors.initials: B
authors.lastname: Shalev
authors.forename: M X
authors.initials: MX
authors.lastname: Repka
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications / Q000503:physiopathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D003867:Depth Perception; D005260:Female; D006801:Humans; D008297:Male; D010468:Perceptual Disorders / Q000209:etiology / Q000503:physiopathology*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D013285:Strabismus / Q000150:complications / Q000503:physiopathology*; D014787:Vision Tests; D015348:Vision, Binocular / Q000502:physiology*; D014792:Visual Acuity