title: Cytokine-secreting tumor cell vaccines.
abstract: Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.
authors.affiliation: Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: N
authors.initials: N
authors.lastname: Mach
authors.forename: G
authors.initials: G
authors.lastname: Dranoff
mesh_terms: D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism*
chemical_list: D019496:Cancer Vaccines; D018664:Interleukin-12; D016178:Granulocyte-Macrophage Colony-Stimulating Factor