Human papillomavirus type 33 DNA in breast cancer in Chinese.
BACKGROUND
The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.


METHODS
We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.


RESULTS
DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.


CONCLUSIONS
Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.
Yu
Y
Y
Department of Pathology, Shanghai First People's Hospital, China.
Morimoto
T
T
Sasa
M
M
Okazaki
K
K
Harada
Y
Y
Fujiwara
T
T
Irie
Y
Y
Takahashi
E
E
Tanigami
A
A
Izumi
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D001943:Breast Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000821:virology*; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000208:ethnology / Q000821:virology*; D002681:China / Q000453:epidemiology; D015344:DNA Probes, HPV; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification*; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D005814:Genes, Viral; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000208:ethnology / Q000821:virology*; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000208:ethnology / Q000821:virology*
D015344:DNA Probes, HPV; D004273:DNA, Neoplasm; D004279:DNA, Viral