[Histamine blockers increase efficacy of specific antidote prophylaxis of intoxication by cholinesterase inhibitors in mice].
Dimedrol and pipolphen, but not loratadine, increase efficacy of the atropine and dipiroxime treatment of mice--an antidote prophylaxis against their intoxication with phosphacol and aminostigmine. The results of experiments confirm a hypothesis that histamine participates in the formation of secondary toxicity reactions in the case of heavy poisoning with anticholinesterase agents.
Prozorovskiĭ
V B
VB
Research Institute of Military Medicine, Ministry of Defense of The Russian Federation, St. Petersburg.
Skopichev
V G
VG
Ditiateva
Zh A
ZhA
Sazonova
A V
AV
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D002219:Carbamates; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use; D004155:Diphenhydramine / Q000627:therapeutic use; D004357:Drug Synergism; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D007928:Lethal Dose 50; D017336:Loratadine / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D010261:Paraoxon / Q000506:poisoning; D011041:Poisoning / Q000517:prevention & control; D011398:Promethazine / Q000627:therapeutic use; D011725:Pyridines; D011729:Pyridostigmine Bromide / Q000031:analogs & derivatives; D014289:Trimedoxime / Q000627:therapeutic use
D000931:Antidotes; D002219:Carbamates; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D006634:Histamine H1 Antagonists; D011725:Pyridines; D014289:Trimedoxime; C070102:aminostigmine; D017336:Loratadine; D001285:Atropine; D004155:Diphenhydramine; D011398:Promethazine; D011729:Pyridostigmine Bromide; D010261:Paraoxon