Autonomic nervous system activity associated with postural disturbances in patients with perilymphatic fistula: sympathetic or vagal origin?
The study focused on patients suffering from perilymphatic fistula (PLF), whether they had undergone surgery or not. Vestibular disturbances can be harmless but are associated with varying symptoms, demonstrating disorders within the autonomic nervous system (ANS). The aim was to test whether the orthosympathetic is involved as the vagal part is often suspected of eliciting a feeling of sickness. Non-invasive and uninterrupted recording of ANS activity represents an objectivation technique to evidence such disturbances. Electrodermal activity, thermovascular variables, instantaneous cardiac rate and blood pressure were recorded. Discomfort was triggered experimentally by applying various stimulations successively to the intact ear then to the PLF (or operated) side. Twelve subjects took part in the experiment. Two types of ANS activity were distinguished: (1) phasic responses during stimulation and (2) tonic evolution thereafter. Results show strong activation in orthosympathetic variables when the PLF side was stimulated. No further significant difference between the two sides was to be observed following surgery. After stimulation, a sudden increase in skin resistance was observed, associated with slight bradycardia. No vagal signs having been evidenced, actual nausea may result from brief inhibition of sympathetic activation resulting, in turn from primary over-activation of this system.
Collet
C
C
Laboratoire de la performance, Université Claude Bernard, Lyon I, Villeurbanne, France. chcollet@univ-lyon1.fr
Vernet-Maury
E
E
Miniconi
P
P
Chanel
J
J
Dittmar
A
A
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D005402:Fistula / Q000150:complications* / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009041:Motion Sickness / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D010498:Perilymph / Q000502:physiology*; D004856:Postural Balance / Q000502:physiology; D011187:Posture / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D012881:Skin Temperature / Q000502:physiology; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014630:Vagus Nerve / Q000503:physiopathology*; D015837:Vestibular Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D014722:Vestibule, Labyrinth / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology