Highly enantioselective addition of diethylzinc to diphenylphosphinoyl imines under dual amino Alcohol/Halosilane mediation
Arylethylene-derived, enantiomerically pure amino alcohols have been evaluated as ligands for the dual-catalyzed (amino alcohol/halosilane) enantioselective addition of diethylzinc to diphenylphosphinoyl imines. Among them, the conformationally restricted 9-fluorenone-derived ligand 4c provides the highest enantioselectivities so far reported over a range of substrate imines.
Jimeno
C
Unitat de Recerca en Sintesi Asimetrica, Departament de Quimica Organica, Universitat de Barcelona, c/Marti i Franques 1-11, E-08028 Barcelona, Spain.
Reddy
KS
Sola
L
Moyano
A
Pericas
MA
Riera
A