title: Prevention of childhood leukemia by BCG vaccination in newborns? A population-based case-control study in Lower Saxony, Germany.
abstract: Data from a case-control study in Lower Saxony, Germany, were used to assess whether the risk for childhood cancer may be reduced by bacille Calmette-Guérin (BCG) vaccination in the neonatal period. There were 420 newly diagnosed childhood cancer cases from the German cancer registry and 613 controls eligible for this study. A mailed questionnaire was completed during a telephone interview with parents. Details on the perinatal history were abstracted from the birth charts by nurses blinded to the children's case-control status. Complete information was available for 259 cases and for 323 controls. A total of 85% of the controls had been BCG vaccinated in the newborn period. The adjusted odds ratios for BCG vaccination were 0.90 (95% confidence interval; 0.51-1.61) for leukemia and 0.61 (95% confidence interval; 0.25-1.50) for other cancers. Based on these data the probability of a 50% or more reduction of more reduction of the cancer risk by BCG vaccination in the newborn period is small. The statistical power of this study, however, was not high enough to rule out a smaller, still relevant reduction in cancer risk.
authors.affiliation: Institut für Soziale Pädiatrie, Ludwig-Maximilians Universität, München, Germany.
authors.forename: R
authors.initials: R
authors.lastname: von Kries
authors.forename: V P
authors.initials: VP
authors.lastname: Grunert
authors.forename: U
authors.initials: U
authors.lastname: Kaletsch
authors.forename: J
authors.initials: J
authors.lastname: Michaelis
authors.forename: U
authors.initials: U
authors.lastname: Göbel
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001500:BCG Vaccine / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000453:epidemiology / Q000517:prevention & control*; D009447:Neuroblastoma / Q000453:epidemiology / Q000517:prevention & control; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000517:prevention & control; D012208:Rhabdomyosarcoma / Q000453:epidemiology / Q000517:prevention & control; D012307:Risk Factors; D009396:Wilms Tumor / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D001500:BCG Vaccine