A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle.
Age-related changes in the mammalian circadian system may be associated with a decline in circulating melatonin levels. Using 'jet lag' paradigms involving abrupt shifts in the light-dark cycle, we showed that a melatonin agonist, S-20098, accelerated by approximately 25% resynchronization of the circadian activity rhythm in old hamsters to the new light-dark cycle. It suggests the usefulness of melatonin-related compounds to treat circadian disorders associated with aging.
Weibel
L
L
Centre d'Etudes des Rythmes Biologiques, School of Medicine, H opital Erasme, Université Libre de Bruxelles, Route de Lennik, 808, 1070, Brussels, Belgium.
Turek
F W
FW
Mocaer
E
E
Van Reeth
O
O
D000081:Acetamides / Q000494:pharmacology*; D000375:Aging / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D006224:Cricetinae; D003624:Darkness; D008027:Light; D008550:Melatonin / Q000819:agonists* / Q000502:physiology; D017440:Photoperiod; D009281:Naphthalenes
D000081:Acetamides; D008550:Melatonin; C084711:agomelatine; D009281:Naphthalenes