title: E2F transcription factors are differentially expressed in murine gametes and early embryos.
abstract: We have examined the murine genes encoding transcription factors E2F1, -3, -5 and -6 in gametes and early embryos. All genes are expressed as maternal transcripts and all are efficiently transcribed after the blastocyst stage. Between those two stages, each E2F mRNA is transcribed with a distinctive and unique pattern. E2F proteins are also differentially expressed and compartmentalized in pre-implantation embryos.
authors.affiliation: Centro di Genetica Evoluzionistica CNR, c/o Dipartimento di Genetica e Biologia Molecolare, Università "La Sapienza", Via degli Apuli 4, 00185, Roma, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Palena
authors.forename: R
authors.initials: R
authors.lastname: Mangiacasale
authors.forename: A R
authors.initials: AR
authors.lastname: Magnano
authors.forename: L
authors.initials: L
authors.lastname: Barberi
authors.forename: R
authors.initials: R
authors.lastname: Giordano
authors.forename: C
authors.initials: C
authors.lastname: Spadafora
authors.forename: P
authors.initials: P
authors.lastname: Lavia
mesh_terms: D016475:3T3 Cells; D000818:Animals; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D050699:E2F3 Transcription Factor; D050700:E2F5 Transcription Factor; D050701:E2F6 Transcription Factor; D005314:Embryonic and Fetal Development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C533431:Arid4a protein, mouse; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D050699:E2F3 Transcription Factor; D050700:E2F5 Transcription Factor; D050701:E2F6 Transcription Factor; C491744:E2F6 protein, human; C493754:E2f1 protein, mouse; C490840:E2f3 protein, mouse; C490490:E2f5 protein, mouse; C111236:E2f6 protein, mouse; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors