title: Longterm central venous access in gynecologic cancer patients.
abstract: BACKGROUND
  To assess the utility and safety of three different longterm indwelling intravenous catheters in patients with gynecologic malignancies.
  
  
  METHODS
  A retrospective review was performed of the records of all women with gynecologic malignancies who required longterm venous access catheters and ports between 1990 and 1997.
  
  
  RESULTS
  Two hundred sixty-eight women underwent placement of 308 indwelling catheters, of which 305 were available for analysis. Of those, 68 (22%) were Hickman catheters, 162 (53%) were infusaports, and 75 (25%) were Peripheral Access System (PAS) ports. Venous access was obtained percutaneously in 152 (50%) patients and by cutdown in 153 (50%). Prophylactic anticoagulation was used with 96 catheters (31%). Catheter placement was associated with 12 (4%) immediate complications and 87 (29%) delayed complications. The average duration of a catheter in place was 5.6 months for the Hickman, 12.5 months for the infusaport, and 16.0 months for the PAS port (p < 0.001). Bacteremia was more likely to develop in patients with Hickman catheters when compared with those with infusaports and PAS ports (19% versus 6% and 5%, respectively, p = 0.002). Thrombosis was significantly less likely to develop in patients receiving prophylactic anticoagulation (11% versus 4%, p = 0.004). Overall, the complication rate was lower with cutdown versus percutaneous access (p = 0.004). There was no statistically significant difference between the frequency of complications when correlated with the stage of disease, patient age, body mass index, or type of malignancy.
  
  
  CONCLUSIONS
  Infusaports and PAS ports were associated with a lower risk of infection and have a longer life than Hickman catheters. The cutdown approach was associated with a lower complication rate. Low-dose prophylactic anticoagulation should be given to all patients with longterm central venous catheters.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA.
authors.forename: V A
authors.initials: VA
authors.lastname: Minassian
authors.forename: A K
authors.initials: AK
authors.lastname: Sood
authors.forename: P
authors.initials: P
authors.lastname: Lowe
authors.forename: J I
authors.initials: JI
authors.lastname: Sorosky
authors.forename: A S
authors.initials: AS
authors.lastname: Al-Jurf
authors.forename: R E
authors.initials: RE
authors.lastname: Buller
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000379:methods; D002408:Catheters, Indwelling / Q000009:adverse effects* / Q000382:microbiology; D016009:Chi-Square Distribution; D005260:Female; D005833:Genital Neoplasms, Female / Q000628:therapy*; D006801:Humans; D015994:Incidence; D008134:Long-Term Care; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013924:Thrombophlebitis / Q000209:etiology* / Q000517:prevention & control