title: Pyrrolo[2,3-d]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of lck I.
abstract: Pyrrolo[2,3-d]pyrimidines containing a 5-(4-phenoxyphenyl) substituent are potent and selective inhibitors of Ick in vitro; some compounds are selective for lck over src. Data are shown for two compounds demonstrating that they are potent and selective inhibitors of IL2 production in cells.
authors.affiliation: BASF Bioresearch Corporation, Worcester, MA 01605-5314, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Arnold
authors.forename: D J
authors.initials: DJ
authors.lastname: Calderwood
authors.forename: R W
authors.initials: RW
authors.lastname: Dixon
authors.forename: D N
authors.initials: DN
authors.lastname: Johnston
authors.forename: J S
authors.initials: JS
authors.lastname: Kamens
authors.forename: R
authors.initials: R
authors.lastname: Munschauer
authors.forename: P
authors.initials: P
authors.lastname: Rafferty
authors.forename: S E
authors.initials: SE
authors.lastname: Ratnofsky
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D019169:Jurkat Cells; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000037:antagonists & inhibitors / Q000378:metabolism; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D042787:Receptor, TIE-2; D017978:Receptors, Growth Factor / Q000037:antagonists & inhibitors / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor; D013379:Substrate Specificity
chemical_list: D004791:Enzyme Inhibitors; D011743:Pyrimidines; D011758:Pyrroles; D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases; D042787:Receptor, TIE-2; D040262:Receptors, Vascular Endothelial Growth Factor; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D016392:Proto-Oncogene Proteins pp60(c-src)