title: Ependymal cyst producing alpha-fetoprotein. Case report.
abstract: This 17-year-old man was admitted to the hospital due to progressive headache and diplopia. Neuroradiological studies revealed a cystic mass in the pineal region without a parenchymal lesion. In addition, serum alpha-fetoprotein (AFP) levels were elevated. A cyst-to-third-ventricle and cistern fenestration was performed, but the cyst enlarged 3 months after the first operation. In the second operation, subtotal resection of the cyst was performed. The AFP level in the cyst fluid was very high preoperatively but was decreased postoperatively. The patient was discharged with no neurological deficit. Pathological examination of resected tissue showed a single layer of cuboidal cells that resembled an ependymal structure. The cells were immunoreactive for AFP immunostain, which indicated AFP production from these cells.
authors.affiliation: Department of Neurosurgery, Chiba-Hokusou Hospital, Nippon Medical School, Tokyo, Japan. jpn2412@mail.webnik.ne.jp
authors.forename: R
authors.initials: R
authors.lastname: Kanazawa
authors.forename: K
authors.initials: K
authors.lastname: Kogure
authors.forename: S
authors.initials: S
authors.lastname: Kominami
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Teramoto
authors.forename: O
authors.initials: O
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003560:Cysts / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D004805:Ependyma / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
chemical_list: D000509:alpha-Fetoproteins