Synthesis of carbapenam skeletons using a ruthenium-catalyzed cyclization.
Carbapenam is a very important skeleton of beta-lactam antibiotics, and it has a highly strained structure. When enynes 9 were treated with RuH(2)CO(PPh(3))(3) (10 mol %) in toluene upon heating, carbapenams 10 were obtained in good yields.
Mori
M
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. mori@pharm.hokudai.ac.jp
Kozawa
Y
Y
Nishida
M
M
Kanamaru
M
M
Onozuka
K
K
Takimoto
M
M
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D015780:Carbapenems / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D012428:Ruthenium
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D012428:Ruthenium