title: [Wolfram syndrome. Urologic implications].
abstract: OBJECTIVE
  We report on four new cases of Wolfram's Syndrome. We emphasize in urological aspects of this disease.
  
  
  METHODS
  Three male siblings. The other patient is also a male, without familiar relation with the other ones. All four patients presents different levels of urological alterations, mainly urinary collecting system dilation and decrease in detrusor muscle contractility.
  
  
  CONCLUSIONS
  Urological findings are cardinal aspects in Wolfram syndrome. Due to its high frequency and prognostic value in natural history of disease. Urological disease seems to be within a systemic neurological tissues affectation of etiology that remains unknown.
authors.affiliation: Servicio de Urología, Hospital Regional Universitario Reina Sofía, Córdoba.
authors.forename: F J
authors.initials: FJ
authors.lastname: Anglada Curado
authors.forename: M
authors.initials: M
authors.lastname: Leva Vallejo
authors.forename: A
authors.initials: A
authors.lastname: Blanco Espinosa
authors.forename: R
authors.initials: R
authors.lastname: Prieto Castro
authors.forename: J C
authors.initials: JC
authors.lastname: Regueiro López
authors.forename: P
authors.initials: P
authors.lastname: Moreno Arcas
authors.forename: M J
authors.initials: MJ
authors.lastname: Requena Tapia
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D014570:Urologic Diseases / Q000209:etiology* / Q000235:genetics; D014929:Wolfram Syndrome / Q000150:complications* / Q000235:genetics