Potential role of endothelin-1 and endothelin antagonists in cardiovascular diseases.
The endothelins comprise a family of three isopeptides ET-1, ET-2 and ET-3, whereby ET-1 appears to be the most relevant in humans. They act in a paracrine manner on ETA and ETB receptors. ET-1 plays an important role in the cardiovascular system. In addition, it modulates vasomotion and growth processes, and it participates in thrombogenesis and neutrophil adhesion. This review summarizes some of the current literature pertaining to the physiological and pathophysiological significance of ET-1, focusing the assets and drawbacks of elevated ET-1 levels. In this regard, modulation of the endothelin system by either receptor blockade or by inhibition of endothelin converting enzyme is expected to provide novel therapeutic drug strategies.
Schmitz-Spanke
S
S
Zentrum für Operative Medizin I, Forschungsgruppe Experimentelle Chirurgie, Heinrich-Heine-Universität Düsseldorf, Germany. schmispa@uni-duesseldorf.de
Schipke
J D
JD
D000818:Animals; D020746:Calcium Channels, L-Type / Q000502:physiology; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology*; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B
D020746:Calcium Channels, L-Type; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B