Nail changes in Langerhans cell histiocytosis.
Nail changes in Langerhans cell histiocytosis are distinctly uncommon. Paronychial erythema, swelling and subungual pustules of the fingernails and toenails were cardinal, and were supported by diffuse as well as dense collections of mononuclear Langerhans cells evidenced by microscopic investigation. Oral administration of co-trimoxazole (800 mg sulphamethoxazole + 160 mg trimethoprim) every 12 h, 50 mg/d cyclophosphamide and 80 mg/d predinisolone were the mainstay of treatment, supported by scalp tar shampoo and local betamethasone lotion application.
Jain
S
S
Skin Care Clinic, Darya Ganj, New Delhi, India.
Sehgal
V N
VN
Bajaj
P
P
D000328:Adult; D001623:Betamethasone / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D009262:Nails / Q000473:pathology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003520:Cyclophosphamide; D001623:Betamethasone