[Eyelid tumor as a recurrence of a gastric MALT-lymphoma].
BACKGROUND
MALT Lymphoma of the conjunctiva, eyelid and orbit represents a primary manifestation of the disease in most of the cases.


METHODS
A 58-year-old male presented with a tumor in the left inferior eyelid. A full-thickness incisional biopsy was performed. Histopathologically, a lymphoid infiltrate involved the eyelid in its full width, with reactive follicles surrounded by small cells with irregular nucleus. Follicular colonization and lymphoepithelial lesions were detected. The tumor was CD20 positive. The molecular genetic analysis disclosed a monoclonal B-cell proliferation. The patient had a history of gastric MALT lymphoma treated 9 years ago and he had been otherwise in good health. The histopathologic features of the gastric tumor were identical to those of the eyelid lesion. Since the eyelid tumor represented a recurrence of the disease, treatment consisted of systemic chemotherapy. Complete tumor eradication was obtained.


CONCLUSIONS
Ocular adnexal MALT-lymphomas may represent a recurrence of a distant primary MALT-lymphoma after a long disease-free period and, therefore, be an indication for systemic chemotherapy.
Colombo
F
F
Augenklinik mit Poliklinik der Friedrich-Alexander-Universität Erlangen-Nürnberg. Fernando.Colombo@augen.med.uni-erlangen.de
Viestenz
A
A
Holbach
L M
LM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000473:pathology*; D016896:Treatment Outcome