title: Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude.
abstract: Exaggerated hypoxia-induced pulmonary hypertension is a hallmark of high-altitude pulmonary edema (HAPE) and plays a major role in its pathogenesis. Many studies of HAPE have estimated systolic pulmonary arterial pressure (SPAP) with Doppler echocardiography. Whereas at low altitude, Doppler echocardiographic estimation of SPAP correlates closely with its invasive measurement, no such evidence exists for estimations obtained at high altitude, where alterations of blood viscosity may invalidate the simplified Bernoulli equation. We measured SPAP by Doppler echocardiography and invasively in 14 mountaineers prone to HAPE and in 14 mountaineers resistant to this condition at 4,559 m. Mountaineers prone to HAPE had more pronounced pulmonary hypertension (57 +/- 12 and 58 +/- 10 mmHg for noninvasive and invasive determination, respectively; means +/- SD) than subjects resistant to HAPE (37 +/- 8 and 37 +/- 6 mmHg, respectively), and the values measured in the two groups as a whole covered a wide range of pulmonary arterial pressures (30-83 mmHg). Spearman test showed a highly significant correlation (r = 0.89, P < 0.0001) between estimated and invasively measured SPAP values. The mean difference between invasively measured and Doppler-estimated SPAP was 0.5 +/- 8 mmHg. At high altitude, estimation of SPAP by Doppler echocardiography is an accurate and reproducible method that correlates closely with its invasive measurement.
authors.affiliation: Swiss Cardiovascular Center Bern, University of Bern, 3010 Bern, Switzerland. Yves.Allemann@insel.ch
authors.forename: Y
authors.initials: Y
authors.lastname: Allemann
authors.forename: C
authors.initials: C
authors.lastname: Sartori
authors.forename: M
authors.initials: M
authors.lastname: Lepori
authors.forename: S
authors.initials: S
authors.lastname: Pierre
authors.forename: C
authors.initials: C
authors.lastname: Mélot
authors.forename: R
authors.initials: R
authors.lastname: Naeije
authors.forename: U
authors.initials: U
authors.lastname: Scherrer
authors.forename: M
authors.initials: M
authors.lastname: Maggiorini
mesh_terms: D000328:Adult; D000531:Altitude; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000379:methods*; D004198:Disease Susceptibility; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D009051:Mountaineering; D011651:Pulmonary Artery / Q000000981:diagnostic imaging* / Q000502:physiology*; D011654:Pulmonary Edema / Q000209:etiology; D013599:Systole