title: Effects of low-density lipoproteins on blood coagulation and fibrinolytic activity.
abstract: In vitro experiments showed that copper-oxidized low-density lipoproteins activate factors of the prothrombin complex in the whole blood and inhibit fibrin generation in both blood and plasma. Moreover, oxidized low-density lipoproteins inhibit fibrinolysis and impair the structure of fibrin clot, which results in hypercoagulation.
authors.affiliation: Laboratory of Biophysical Basis of Pathology, Institute of Physicochemical Medicine, Russian Ministry of Health.
authors.forename: O A
authors.initials: OA
authors.lastname: Azizova
authors.forename: E V
authors.initials: EV
authors.lastname: Roitman
authors.forename: I I
authors.initials: II
authors.lastname: Dement'eva
authors.forename: N A
authors.initials: NA
authors.lastname: Nikitina
authors.forename: E V
authors.initials: EV
authors.lastname: Gagaeva
authors.forename: Y M
authors.initials: YM
authors.lastname: Lopukhin
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D003300:Copper / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011517:Prothrombin Time; D013916:Thrombelastography; D013918:Thrombin Time
chemical_list: D008077:Lipoproteins, LDL; D003300:Copper