title: Peptidyl transferase: ancient and exiguous.
abstract: The finding that the universal ribosomal peptidyl transferase is an RNA enzyme casts new light on its ancient origins, on the use of transition state analogues for ribozymes, and on the role of selection-amplification in studies of molecular evolution.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Universityof Colorado, Boulder 80309-0347, USA. yarus@stripe.colorado.edu
authors.forename: M
authors.initials: M
authors.lastname: Yarus
authors.forename: M
authors.initials: M
authors.lastname: Welch
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D019143:Evolution, Molecular; D009690:Nucleic Acid Conformation; D010458:Peptidyl Transferases / Q000737:chemistry / Q000378:metabolism*; D012313:RNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism*; D012270:Ribosomes / Q000201:enzymology / Q000235:genetics / Q000378:metabolism
chemical_list: D016337:RNA, Catalytic; D012313:RNA; D010458:Peptidyl Transferases