G protein variation in respiratory syncytial virus group A does not correlate with clinical severity.
Respiratory syncytial virus group A strain variations of 28 isolates from The Netherlands collected during three consecutive seasons were studied by analyzing G protein sequences. Several lineages circulated repeatedly and simultaneously during the respective seasons. No relationships were found between lineages on the one hand and clinical severity or age on the other.
Brandenburg
A H
AH
Institute of Virology, Erasmus University Hospital, 3000 DR Rotterdam, The Netherlands.
van Beek
R
R
Moll
H A
HA
Osterhaus
A D
AD
Claas
E C
EC
D001049:Apnea; D014644:Genetic Variation; D015707:HN Protein; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009426:Netherlands; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D015656:Respiratory Mechanics; D018357:Respiratory Syncytial Virus Infections / Q000503:physiopathology* / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000235:genetics* / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000235:genetics*
D015707:HN Protein; D012367:RNA, Viral; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C116204:attachment protein G