Parvovirus-mediated antineoplastic activity exploits genome instability.
The generation and accumulation of genetic mutations have been associated with carcinogenesis. Epidemiological and experimental evidence implicate parvoviruses in growth inhibition (oncosuppression) and selective destruction (oncolysis) of tumor cells. It is proposed here that parvoviruses can preferentially target genetically unstable tumor cells, which are deficient in DNA repair mechanisms. This selective strategy may serve as a virus-based therapeutic approach against cancer.
Shadan
F F
FF
Scripps Clinic and Research Foundation, Green Hospital, Internal Medicine, Medical Education, La Jolla, California 92037, USA. Fshadan@Scripps.edu
Villarreal
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LP
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D010322:Parvoviridae Infections / Q000453:epidemiology / Q000503:physiopathology*; D017992:Parvovirus / Q000235:genetics*; D014407:Tumor Cells, Cultured