title: Vanishing bile duct syndrome in Hodgkin's disease: case report.
abstract: BACKGROUND
  Liver damage is relatively common in patients affected by Hodgkin's disease. A smaller proportion of cases develops jaundice. Recently, the vanishing bile duct syndrome was described in Hodgkin's disease. The mechanisms of this severe complication have been poorly understood until now.
  
  
  OBJECTIVE
  To describe a rare case of intra-hepatic cholestasis due to vanishing bile duct syndrome.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A 38-year-old male patient affected by Hodgkin's disease. Liver biopsy showed no detectable Hodgkin's disease. Intra-hepatic cholestasis was found and none of the six portal tracts analyzed contained normal bile ducts. The treatment was based on conventional and high-dose escalation chemotherapy. The patient died from an irreversible liver failure while in complete remission from Hodgkin's disease.
authors.affiliation: Hematology and Blood Transfusion Center, State University of Campinas, Campinas, Brazil.
authors.forename: M S
authors.initials: MS
authors.lastname: Rossini
authors.forename: I
authors.initials: I
authors.lastname: Lorand-Metze
authors.forename: G B
authors.initials: GB
authors.lastname: Oliveira
authors.forename: C A
authors.initials: CA
authors.lastname: Souza
mesh_terms: D000328:Adult; D002779:Cholestasis / Q000209:etiology; D003137:Common Bile Duct Diseases / Q000150:complications / Q000209:etiology*; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000473:pathology; D008297:Male; D013577:Syndrome