An evaluation of the hemostatic effect of externally applied notoginseng and notoginseng total saponins.
No effective hemostatic agents are available for external use. This project was conducted to evaluate the hemostatic effects of notoginseng using a hemorrhagic rat model. Rats (n = 40) were divided into four groups, and their tails were transected 5 mm from the tip. Group 1 received no treatment (control), while the other groups received external powder applied to the wound. Group 2 received placebo (flour), group 3 received ground notoginseng, and group 4 received a saponin extract of notoginseng. The total bleeding time was determined and compared between groups. The notoginseng group had lower bleeding times (9.60 +/- 1.50 min) than the control group (19.23 +/- 4.09 min, p < 0.001) or the placebo group (15.18 +/- 2.24 min, p < 0.001). Likewise, the saponin extract group had significantly lower bleeding times (11.70 +/- 2.53 min) than the control and placebo groups (p < 0.001 for both comparisons). No differences were found between the notoginseng and the saponin extract groups (p = 0.35). Notoginseng and a saponin extract from notoginseng provide hemostatic effects when applied externally.
White
C M
CM
Hartford Hospital, Department of Pharmacy, Connecticut, USA.
Fan
C
C
Chow
M
M
D000704:Analysis of Variance; D000818:Animals; D001760:Bleeding Time; D004341:Drug Evaluation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology*; D023421:Models, Animal; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D006490:Hemostatics; D010936:Plant Extracts; D012503:Saponins