Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients.
Three girls, two aged 12 years and one aged 17 years with refractory localization-related epilepsy were treated on an add-on basis with tiagabine. At dosages 22.5-30 mg/day (0.45-0.57 mg/kg/day) longstanding non-convulsive status epilepticus was noted in all three patients. The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages. In two cases, tiagabine was withdrawn, whereas it was continued at a lower dosage in one case. This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.
Balslev
T
T
Division of Paediatric Neurology, Department of Paediatrics, Skejby, Arhus University Hospital, Arhus N, Denmark. skejtba@aau.dk
Uldall
P
P
Buchholt
J
J
D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D018755:GABA Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D014179:Neurotransmitter Uptake Inhibitors / Q000009:adverse effects*; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D000078308:Tiagabine
D000927:Anticonvulsants; D018755:GABA Agonists; D014179:Neurotransmitter Uptake Inhibitors; D009557:Nipecotic Acids; D000078308:Tiagabine