title: Association between heart rate-corrected QT interval and coronary risk factors in 2,894 healthy subjects (the DESIR Study). Data from an Epidemiological Study on the Insulin Resistance syndrome.
abstract: In the prospective Data from an Epidemiological Study on the Insulin Resistance Syndrome, 2,894 healthy subjects aged 30 to 64 years had determinations of fasting glucose, insulin, serum lipid and fibrinogen concentrations, blood pressures, body mass index, and waist-hip ratio, as well as tobacco and alcohol consumptions and physical activity. A 12-lead electrocardiogram with automatic measurement of the QT interval was recorded and the formula used for heart rate correction was based on the best-fit regression between QT and heart rate. The QT duration was influenced by glucose homeostasis in both sexes, and increased in men with physical activity; there was a dose-effect relation for men who smoked.
authors.affiliation: Service de Cardiologie B, Centre Hospitalier Universitaire Trousseau, Tours, France. lfau@med.univ-tours.fr
authors.forename: L
authors.initials: L
authors.lastname: Fauchier
authors.forename: P
authors.initials: P
authors.lastname: Maison-Blanche
authors.forename: A
authors.initials: A
authors.lastname: Forhan
authors.forename: A
authors.initials: A
authors.lastname: D'Hour
authors.forename: P
authors.initials: P
authors.lastname: Lépinay
authors.forename: J
authors.initials: J
authors.lastname: Tichet
authors.forename: S
authors.initials: S
authors.lastname: Vol
authors.forename: P
authors.initials: P
authors.lastname: Coumel
authors.forename: J P
authors.initials: JP
authors.lastname: Fauchier
authors.forename: B
authors.initials: B
authors.lastname: Balkau
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003327:Coronary Disease / Q000209:etiology* / Q000401:mortality; D003645:Death, Sudden / Q000209:etiology; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000503:physiopathology
chemical_list: D001786:Blood Glucose