Peroxisome proliferator-activated receptor-alpha expression in rat liver during postnatal development.
The expression of the peroxisome proliferator-activated receptor-alpha (PPARalpha) as well as of some related genes was studied in rat liver at different stages of development (from 19-day-old fetuses to 1 month-old rats). The level of PPARalpha mRNA appeared higher in neonates than in fetuses or 1 month-old rats. Whereas the pattern for phosphoenolpyruvate carboxykinase (PEPCK) mRNA level was similar to that of PPARalpha, the mRNA level of both acyl-CoA oxidase (ACO) and apolipoprotein CIII (apo CIII) showed diverse profiles. Western blotting analysis also revealed an increased level of PPARalpha protein in liver of suckling rats. Similarities of mRNA PEPCK and PPARalpha expression indicate a common control mechanism, where both nutritional and hormonal factors may be involved.
Panadero
M
M
Facultad de Ciencias Experimentales y Técnicas, Universidad San Pablo-CEU, P.O. Box 67, 28660 Boadilla del Monte, Madrid, Spain.
Herrera
E
E
Bocos
C
C
D042962:Acyl-CoA Oxidase; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000235:genetics; D005314:Embryonic and Fetal Development; D018507:Gene Expression Regulation, Developmental; D008099:Liver / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics; D010088:Oxidoreductases / Q000235:genetics; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; D009687:Nuclear Proteins; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase; D010729:Phosphoenolpyruvate Carboxykinase (GTP)