Pre- and postsynaptic effects of eugenol and related compounds on Helix pomatia L. neurons.
We showed how eugenol blocks the synaptic transmission and gave a possible interpretation how it inhibits the excitation-contraction coupling that several authors described previously. Eugenol acts both in the pre- and postsynaptic side of the neurons. It blocks the Ca2+-currents, decreases the membrane potential of the neurons, increases the inward resistance and decreases the GABA, ACh and glutamate evoked excitatory responses in submillimolar concentration.
Szabadics
J
J
Department of Comparative Physiology, József Attila University, Szeged, Hungary. 4532.387@stud.u.-szeged.hu
Erdélyi
L
L
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects; D005054:Eugenol / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects; D018698:Glutamic Acid / Q000494:pharmacology; D006139:Guaiacol / Q000494:pharmacology; D006372:Helix, Snails / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018698:Glutamic Acid; D005054:Eugenol; D005680:gamma-Aminobutyric Acid; D006139:Guaiacol; D000109:Acetylcholine