New bioactive aromatic compounds from Vismia guianensis.
Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic.
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Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA.
Wani
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MC
Wall
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Navarro
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Mukherjee
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Farnsworth
N R
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Kinghorn
A D
AD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D004247:DNA / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D013057:Spectrum Analysis
D000972:Antineoplastic Agents, Phytogenic; D001577:Benzophenones; D004247:DNA