Immunization. Update: search for an AIDS vaccine.
Identifying a successful HIV preventive vaccine is among the highest research priorities of the US NIH. While therapies for HIV have brought hope to those who are already HIV-infected, stopping the worldwide epidemic will require safe, effective HIV vaccines. Here, we describe scientific and other obstacles to attaining that goal and provide a brief synopsis of clinical trial results, recent preclinical results, and future priorities.
Bende
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Vaccine and Prevention Research Program, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Md., USA.
Johnston
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MI
D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D002986:Clinical Trials as Topic; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D018928:Immunity, Mucosal; D007114:Immunization; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology
D016915:AIDS Vaccines; D019444:Vaccines, DNA