Effect of mitomycin-C on posterior capsule opacification in rabbit eyes.
OBJECTIVE
To determine whether mitomycin-C can inhibit posterior capsule opacification (PCO) without causing ocular toxicity.


METHODS
Yonsei Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea.


METHODS
Mitomycin-C dissolved in sodium hyaluronate (0.2 cc of 0.2 mg/mL) was injected into the empty capsular bag for 3 minutes after endocapsular phacoemulsification in rabbit eyes. Three months after surgery, the obstruction rate of visible light caused by PCO was measured using an optical power meter.


RESULTS
The mean obstruction rate of visible light was 81.0% +/- 8.3% (SD) in the control group in which sodium hyaluronate without mitomycin-C was used, 30.5% +/- 10.1% in the group in which mitomycin-C was dissolved in sodium hyaluronate, and 71.9% +/- 6.8% in the group in which mitomycin-C was dissolved in a balanced salt solution. Statistically significant differences were found among all 3 groups.


CONCLUSIONS
Our results suggest that the application of mitomycin-C dissolved in sodium hyaluronate effectively reduces PCO in rabbit eyes.
Chung
H S
HS
Yonsei Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea. hschung@iupui.edu
Lim
S J
SJ
Kim
H B
HB
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002386:Cataract / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002455:Cell Division / Q000187:drug effects; D004338:Drug Combinations; D006820:Hyaluronic Acid / Q000008:administration & dosage; D007267:Injections; D007903:Lens Capsule, Crystalline / Q000187:drug effects / Q000473:pathology; D016685:Mitomycin / Q000008:administration & dosage*; D018918:Phacoemulsification / Q000009:adverse effects; D011817:Rabbits
D000276:Adjuvants, Immunologic; D000903:Antibiotics, Antineoplastic; D004338:Drug Combinations; D016685:Mitomycin; D006820:Hyaluronic Acid