title: L-asparaginase-provoked seizures as singular expression of central nervous toxicity.
abstract: Patients treated with L-asparaginase may present with hemorrhagic and thrombotic cerebrovascular events. This syndrome generally occurs after a few weeks of therapy and may occur after L-asparaginase therapy is completed. Complications appear to result from depletion of plasma proteins involved in coagulation and fibrinolysis. Seizures are uncommon symptoms, and are always caused by cerebrovascular events. We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events.
authors.affiliation: Department of Medicine, University of Texas Southwestern Medical School, Dallas 75231, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Hamdan
authors.forename: E P
authors.initials: EP
authors.lastname: Frenkel
authors.forename: R
authors.initials: R
authors.lastname: Bick
mesh_terms: D000328:Adult; D001215:Asparaginase / Q000008:administration & dosage / Q000633:toxicity*; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced*
chemical_list: D001215:Asparaginase