Hydrogen iodide-promoted reduction of beta-chlorovinamidinium salts
HI cleanly reduced chlorovinamidinium salts to the vinamidinium salt in essentially quantitative assay yield and 55-85% isolated yield following recrystallization. The reaction proceeds via protonation of the beta-carbon atom of the vinamidinium and dechlorination via the formation of I-Cl.
Davies
IW
Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA.
Taylor
M
Hughes
D
Reider
PJ