title: Leukotriene receptor antagonists for non-cystic fibrosis bronchiectasis.
abstract: BACKGROUND
  Leukotriene receptor antagonists are a new class of drug that were initially identified for use in asthma. As they have an effect on neutrophil mediated inflammation, they may be of benefit in bronchiectasis.
  
  
  OBJECTIVE
  To determine whether leukotriene receptor antagonists have any additive benefit over and above conventional treatment for bronchiectasis (usually consisting of antibiotics and postural drainage).
  
  
  METHODS
  The Cochrane Airways Group clinical trials register derived from MEDLINE, EMBASE and hand searching of major journals was searched using the terms:Bronchiec* AND leukotrien* OR anti-leuk* OR cysteinyl, Bronchiec* AND monteluk*, Bronchiec* AND zafirluk*
  
  
  METHODS
  Only randomised, controlled trials were considered
  
  
  METHODS
  The results of searches were analysed by both authors
  
  
  RESULTS
  No randomised, controlled trials were identified
  
  
  CONCLUSIONS
  Further research is required to establish any benefit from the use of leukotriene antagonists in bronchiectasis.
authors.affiliation: Aintree Chest Centre, University Hospital, Aintree, Aintree Chest Centre, University Hospital Aintree, Lower Lane, Liverpool, Merseyside, UK, L9 7AL. j.corless@bigfoot.com
authors.forename: J A
authors.initials: JA
authors.lastname: Corless
authors.forename: C J
authors.initials: CJ
authors.lastname: Warburton
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D001987:Bronchiectasis / Q000188:drug therapy* / Q000209:etiology; D002986:Clinical Trials as Topic; D003521:Cyclopropanes; D006801:Humans; D007211:Indoles; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D048448:Phenylcarbamates; D010919:Placebos; D011804:Quinolines / Q000627:therapeutic use; D013440:Sulfides; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000627:therapeutic use
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D010919:Placebos; D011804:Quinolines; D013440:Sulfides; D013449:Sulfonamides; D014105:Tosyl Compounds; C093875:montelukast; C062735:zafirlukast