Effect of risperidone on prolactinoma growth in a psychotic woman.
OBJECTIVE
The case of a psychotic woman is described in which risperidone use was found to correspond with an increase in the size of a prolactinoma and prevented the return of serum prolactin level to baseline.


METHODS
Although the patient had been treated with a high dose of bromocriptine, her prolactin level remained elevated, causing persistent galactorrhea. The patient later was treated with olanzapine and carbamazepine successfully.


RESULTS
This case report highlights the role of risperidone on prolactin and discusses alternative methods of treating psychosis when the etiology is unclear, especially in younger patients.


CONCLUSIONS
The authors recommend that additional studies regarding the relationship between the growth of prolactinoma and atypical antipsychotics would be worthwhile.
Pal
J K
JK
Department of Psychiatry, Mt. Sinai Hospital, Chicago, IL, USA.
Sarino
W A
WA
D000293:Adolescent; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D015175:Prolactinoma / Q000097:blood / Q000150:complications / Q000175:diagnosis; D011618:Psychotic Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D018967:Risperidone / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000097:blood / Q000378:metabolism*
D014150:Antipsychotic Agents; D005680:gamma-Aminobutyric Acid; D011388:Prolactin; D018967:Risperidone