Effect of degree of blood pressure on the hypercoagulable state in chronic atrial fibrillation.
To investigate the hypothesis that higher levels of blood pressure would further promote the hypercoagulable state in atrial fibrillation (AF) by increasing the degree of hemostatic abnormalities, we studied 82 consecutive patients with chronic nonvalvular AF who were not taking antithrombotic therapy. Patients with AF had higher levels of plasma fibrin D-dimer, von Willebrand factor, and fibrinogen than controls in sinus rhythm, and no differences between tertiles of either systolic, diastolic, or mean blood pressure were found, suggesting other mechanisms may be contributing to the hypercoagulable state in AF.
Li-Saw-Hee
F L
FL
University Department of Medicine, City Hospital, Birmingham, United Kingdom.
Blann
A D
AD
Lip
G Y
GY
D000368:Aged; D001281:Atrial Fibrillation / Q000097:blood / Q000503:physiopathology*; D001777:Blood Coagulation / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002908:Chronic Disease; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014841:von Willebrand Factor / Q000378:metabolism
D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D014841:von Willebrand Factor; D005340:Fibrinogen