title: The effect of repeated bilateral electroconvulsive therapy on seizure threshold.
abstract: Seizure threshold was measured by empirical titration in 28 patients referred for bilateral electroconvulsive therapy to treat depressive illness at the outset of treatment and after another six treatments. No patient was given antiepileptic drug treatment, and anesthetic technique and concomitant psychotropic drug treatment were fixed. The average (+/- SD) initial seizure threshold measured by set charge was 79.5 mC (+/- 33.4 mC), and this increased to 95.5 mC (+/- 37.9 mC). The average percentage increase was 22.8% (95% confidence interval, 13.7% to 31.8%). The seizure threshold measured by set charge did not change in 15 patients (54%), and there was no significant relation between change in seizure threshold and patient sex, change in seizure duration measured by cuff technique, or global clinical improvement during the course of treatment.
authors.affiliation: Andrew Duncan Clinic, Royal Edinburgh Hospital, Edinburgh, Scotland, United Kingdom.
authors.forename: A I
authors.initials: AI
authors.lastname: Scott
authors.forename: H
authors.initials: H
authors.lastname: Boddy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003866:Depressive Disorder / Q000503:physiopathology / Q000628:therapy; D004565:Electroconvulsive Therapy / Q000295:instrumentation; D005260:Female; D006801:Humans; D007206:Individuality; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012640:Seizures / Q000503:physiopathology*; D013997:Time Factors