Effect of paroxetine on thyroid hormone levels in severely depressed patients.
There are very divergent appraisals of the effect of antidepressants on thyroid parameters and their possible correlation with the response. Whereas there are numerous investigations of tricyclic antidepressants, so far, there are only limited data on the possible effect of serotonin-selective reuptake inhibitors on neuroendocrine parameters. The present study showed a significant reduction of 11. 2% in thyroxine during treatment with 20 mg paroxetine in 25 severely depressed patients.
König
F
F
Department of Psychiatry I, University of Ulm, Ravensburg, Germany.
Hauger
B
B
von Hippel
C
C
Wolfersdorf
M
M
Kaschka
W P
WP
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects / Q000627:therapeutic use*; D013405:Suicide / Q000523:psychology; D013963:Thyroid Hormones / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D000092864:Suicide Prevention
D018687:Antidepressive Agents, Second-Generation; D013963:Thyroid Hormones; D017374:Paroxetine; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine