Thromboembolic prophylaxis with danaparoïd (Orgaran) in a high-thrombosis-risk pregnant woman with a history of heparin-induced thrombocytopenia (HIT) and Widal's disease.
There is no consensus concerning thromboembolic prophylaxis in high-risk pregnant women with a previous history of heparin-induced thrombocytopenia. An alternative anticoagulant therapy is danaparoïd, whereas unfractioned and low-molecular-weight heparin therapy is contraindicated. We report a case of successful thrombosis prophylaxis using danaparoïd in a high-thrombosis-risk pregnant woman with a history of heparin-induced thrombocytopenia during a previous pregnancy and Widal's disease.
Macchi
L
L
Laboratoire d'Hématologie, CHU de Poitiers, France.
Sarfati
R
R
Guicheteau
M
M
Chamlian
V
V
Pourrat
O
O
Gruel
Y
Y
Magnin
G
G
Brizard
A
A
Boinot
C
C
D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced / Q000150:complications; D002511:Cephalosporins / Q000009:adverse effects; D002809:Chondroitin Sulfates / Q000008:administration & dosage*; D003871:Dermatan Sulfate / Q000008:administration & dosage*; D004338:Drug Combinations; D004342:Drug Hypersensitivity; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006496:Heparinoids / Q000008:administration & dosage; D006497:Heparan Sulfate / Q000008:administration & dosage*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy*; D012307:Risk Factors; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced / Q000150:complications; D013923:Thromboembolism / Q000188:drug therapy / Q000517:prevention & control*
D000925:Anticoagulants; D001241:Aspirin; D002511:Cephalosporins; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D004338:Drug Combinations; D006493:Heparin; D006496:Heparinoids; D006497:Heparan Sulfate; C035838:danaparoid