Clinical rubella reinfection during pregnancy in a previously vaccinated woman.
We report a documented case of clinically apparent rubella reinfection during pregnancy with rubelliform rash and fever followed by lymphodenopathy at the 18th week of gestation, in a previously vaccinated woman with haemagglutination inhibition (HI) antibody titre of 1:32. The serological tests results (including neutralizing antibodies) demonstrated a significant rise in her rubella specific IgG level with strongly positive IgM reactivity. In addition, rubella-specific IgG antibody avidity testing displayed high avidity index (53-88%) typical of rubella reinfection. Umbilical cord blood, drawn by sonographic-guided cordocentesis at 24 weeks' gestation, was found to be negative for rubella-specific IgM antibody. The pregnancy was continued to term, and a healthy infant was born.
Aboudy
Y
Y
Central Virology Laboratory, Public Health Services, Ministry of Health and The Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel.
Barnea
B
B
Yosef
L
L
Frank
T
T
Mendelson
E
E
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D011262:Pregnancy Trimester, Second; D012008:Recurrence; D012409:Rubella / Q000276:immunology*; D012411:Rubella Vaccine; D012412:Rubella virus / Q000276:immunology*; D012698:Serologic Tests
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012411:Rubella Vaccine