Effects of a vasopressin antagonist in women with dysmenorrhea.
We compared menstrual pain, uterine contractility and blood circulation, and plasma concentrations of vasopressin and prostaglandin F(2alpha) metabolite in women with versus without primary dysmenorrhea, and determined the effects of a vasopressin antagonist, 1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxytocin (Atosiban), on these parameters. Our results do not support the contention that vasopressin is involved in the etiology of dysmenorrhea, plasma concentrations of vasopressin being similar in dysmenorrheic women and controls, and the vasopressin antagonist Atosiban having no effect on menstrual pain, intrauterine pressure or uterine artery pulsatility index in dysmenorrheic women.
Valentin
L
L
Department of Obstetrics and Gynecology, Lund University, University Hospital, Malmö, Sweden.
Sladkevicius
P
P
Kindahl
H
H
Broeders
A
A
Marsal
K
K
Melin
P
P
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D018592:Cross-Over Studies; D015237:Dinoprost / Q000378:metabolism; D004311:Double-Blind Method; D004412:Dysmenorrhea / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000098:blood supply / Q000187:drug effects; D014667:Vasopressins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014668:Vasotocin / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D006727:Hormone Antagonists; C047046:atosiban; D014667:Vasopressins; D015237:Dinoprost; D014668:Vasotocin