A fundamental transcription factor for bone and cartilage.
Cbfa1-deficient mice were found to show a complete lack of bone formation owing to the maturational arrest of osteoblasts. Cbfa1 plays key roles in the determination of osteoblastic lineage from multipotential mesenchymal cells, their differentiation into mature osteoblasts, and transcriptional regulation of bone matrix-related genes. Cbfa1 positively regulates chondrocyte maturation and osteoclast differentiation and is required for vascular invasion into cartilage. Therefore, complete elucidation of the function of Cbfa1 and its signaling would be of great benefit in understanding skeletogenesis.
Komori
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Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka, 565-0871, Japan.
D000818:Animals; D001842:Bone and Bones / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D002356:Cartilage / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage; D019902:Chondrocytes / Q000166:cytology; D050659:Core Binding Factor Alpha 1 Subunit; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm / Q000166:cytology; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins; D010006:Osteoblasts / Q000166:cytology; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D050659:Core Binding Factor Alpha 1 Subunit; D009363:Neoplasm Proteins; D014157:Transcription Factors