title: The treatment of essential voice tremor with botulinum toxin A: a longitudinal case report.
abstract: The purpose of this study was to evaluate the effects of bilateral botulinum toxin injection into the thyroarytenoid (TA) muscles of a patient with essential voice tremor. Acoustic and aerodynamic data were collected weekly over a 16-week period. Flexible nasolaryngoscopy was performed prior to injection and 2, 6, 10, and 16 weeks postinjection. Perceptual analyses of the acoustic and nasolaryngoscopic data were performed. A reduction in frequency tremor and, to a lesser extent, amplitude tremor was observed during the 1-10 week period. Estimated laryngeal resistance decreased after injection and was accompanied in perceptual measures by a reduction in vocal effort, laryngeal tremor, and supraglottic hyperfunction. Essential voice tremor can be successfully attenuated with bilateral percutaneous injection of botulinum toxin A into the vocalis muscle.
authors.affiliation: Department of Otolaryngology, Toronto General Hospital, University of Toronto, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Warrick
authors.forename: C
authors.initials: C
authors.lastname: Dromey
authors.forename: J
authors.initials: J
authors.lastname: Irish
authors.forename: L
authors.initials: L
authors.lastname: Durkin
mesh_terms: D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D004576:Electromyography; D006801:Humans; D007273:Injections, Intramuscular; D007821:Laryngeal Muscles; D008297:Male; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D013018:Sound Spectrography; D013997:Time Factors; D014202:Tremor / Q000175:diagnosis / Q000188:drug therapy*; D014832:Voice Disorders / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A