Oral involvement in mycosis fungoides: report of two cases and a literature review.
Oral involvement is uncommon in cutaneous T-cell lymphomas and usually associated with poor prognosis. The clinicopathological and immunohistochemical findings of 2 new cases are described along with a literature review. The first patient had a 10-year history of mycosis fungoides when she developed lesions in the oral tissues. She died 6 months later despite treatment. The immunophenotype was CD3+, CD4+, CD8-, CD30-. The second patient had a mycosis fungoides for 5 years when she developed lesions in the uvula and oropharynx. She was treated with polychemotherapy and she is alive 5 years after oral involvement. The immunophenotype was CD3+, CD4-, CD8+, CD30-. There are conflicting reports about the prognosis in the CD8+ phenotype. The present cases and the literature review seem to indicate that in oral involvement the CD8- phenotype is not associated with a worse prognosis than the CD4+ subtype. However, it is necessary to study new cases to confirm this statement.
de la Fuente
E G
EG
Department of Dermatology, 12 de Octubre University Hospital, Madrid, Spain.
Rodriguez-Peralto
J L
JL
Ortiz
P L
PL
Barrientos
N
N
Vanaclocha
F
F
Iglesias
L
L
D000368:Aged; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000556:secondary*; D009182:Mycosis Fungoides / Q000473:pathology*; D009959:Oropharyngeal Neoplasms / Q000556:secondary; D012878:Skin Neoplasms / Q000473:pathology*; D014062:Tongue Neoplasms / Q000556:secondary; D014609:Uvula
D015704:CD4 Antigens; D016827:CD8 Antigens