Prevalence of Huntington disease in New South Wales in 1996.
OBJECTIVE
To estimate the prevalence of Huntington disease (HD) in New South Wales on Australian Census Day (6 August) 1996.


METHODS
Survey of records of the Huntington Disease Service and major hospitals, and of neurologists, psychiatrists, clinical geneticists and genetic counsellors.


METHODS
All patients in NSW who, on Census Day 1996, either had a definite diagnosis of HD (motor signs of chorea or ataxia and family history of HD or positive DNA test result) or would have had signs and later received a definite diagnosis (assessed 1 April 1997 to 1 July 1999).


METHODS
Prevalence (HD patients per 100,000 population); patient characteristics; year and basis of diagnosis.


RESULTS
380 patients with definite HD were identified, giving a prevalence of HD in NSW in 1996 of 6.29 per 100,000 population (95% CI, 5.68-6.96). A third of HD patients were aged 60 years or older. Diagnosis was confirmed by DNA testing for 171 patients (45%), including 30 (8%) with no recorded family history. Average numbers of new diagnoses per year were 11.8 (1984-1988), 21.8 (1989-1993) and 28.6 (1994-1998). Estimated number of people with a 50% risk of inheriting the HD mutation was 25.2 per 100,000 population. Estimated incidence of HD in 1996 was 0.65 per 100,000 population.


CONCLUSIONS
Prevalence of HD in NSW is similar to estimated prevalence in other Australian and Western populations. Increasing numbers of cases are being diagnosed, and the 18 chronic care beds currently designated for HD patients in NSW are unlikely to be sufficient.
McCusker
E A
EA
Neurology Department, Westmead Hospital, Sydney, NSW. elizabeth_mccusker@mail.wmi.usyd.edu.au
Casse
R F
RF
Graham
S J
SJ
Williams
D B
DB
Lazarus
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004247:DNA / Q000032:analysis; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D015995:Prevalence
D004247:DNA