[Effect of prenatal emotional-pain stress on the status of interphase chromatin in neurons of the rat developing brain with various excitation of the nervous system].
A short-term emotional-painful stress, experienced by pregnant rat females differing in threshold of excitability of their nervous system, was used to assess the state of interphase condensed chromatin and C-heterochromatin of neuron nuclei in developing brains of 16-17 day old embryos. To reveal relationships between the genetically determined excitability of rats and the state of interphase chromatin in their neuron nuclei a computer information system has been used that enabled us to classify the neuronal nuclei according to their specific DNA image cytometry features. The results indicate an obvious relationship between excitability of the nervous system and structural-functional state of the neuronal interphase chromatin.
Diuzhikova
N A
NA
Institute of Physiology RAS, St. Petersburg.
Vaĭdo
A I
AI
Lopatina
N G
NG
Mironov
S V
SV
Dudkin
K N
KN
D000818:Animals; D001921:Brain / Q000196:embryology* / Q000473:pathology / Q000502:physiology; D002843:Chromatin / Q000378:metabolism*; D005260:Female; D007399:Interphase; D009474:Neurons / Q000378:metabolism*; D010146:Pain / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*
D002843:Chromatin