Assessment of kainate toxicity using contrast enhanced magnetic resonance imaging.
The purpose of this study was to test the capability of contrast enhanced magnetic resonance imaging (MRI) in assessing lesion formation in rat brain after systemic (i.v.) administration of kainate. MRI was performed with T1-weighted spin echo sequence before and after the administration of kainate and contrast media. Contrast media used were based on paramagnetic gadolinium (III) ion: Gd-DTPA (gadoliniumdiethylenetriaminepentaacetic acid) and prototype agents for blood-pool enhancement. Gadomer-17 and polylysine-Gd-DTPA. Enhancement of lesion rims and other brain tissue abnormalities due to kainate with Gd-DTPA, Gadomer-17 and polylysine-Gd-DTPA were observed mainly in the region of hippocampus and in the areas not protected by the blood-brain-barrier (BBB).
Beravs
K
K
Institute Jozef Stefan, Ljubljana, Slovenia.
Frangez
R
R
Demsar
F
F
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D007089:Image Enhancement; D007608:Kainic Acid / Q000506:poisoning; D008279:Magnetic Resonance Imaging; D011107:Polylysine / Q000031:analogs & derivatives*; D051381:Rats; D017208:Rats, Wistar
D003287:Contrast Media; C402765:gadomer 17; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D005682:Gadolinium; D019786:Gadolinium DTPA; D007608:Kainic Acid