Photosensitivity associated with treatment with triflusal.
BACKGROUND
Triflusal is a fluorinated aspirin derivative with antiplatelet properties, which is used in Spain for the management and prevention of thromboembolic disease.


METHODS
A 91-year-old female developed a systemic photosensitivity reaction 15 days after beginning triflusal preventive treatment (300 mg/12 h) for prior transient ischaemic attack. Photobiological study showed an abnormal response to light in areas exposed to ultraviolet B and A radiation, with a photopatch test positive to both triflusal and its main metabolite. These observations suggested a causal relation between triflusal and the clinical findings, as described in previous reports.


CONCLUSIONS
The few cases reported to date and the clinicopathological features of this case suggested an immunological response as the most likely cause of the reaction.
Nagore
E
E
Department of Dermatology, Hospital General Universitario, Valencia, Spain. eduyame@meditex.es
Pérez-Ferriols
A
A
Sánchez-Motilla
J M
JM
Serrano
G
G
Aliaga
A
A
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012459:Salicylates / Q000009:adverse effects*
D010975:Platelet Aggregation Inhibitors; D012459:Salicylates; C016167:triflusal