Diurnal variation in the P300 component of human cognitive event-related potential.
Diurnal variation in the P300 component of the human cognitive event-related potential (ERP) was examined. The P300 component is considered to be a measure of neuroelectric activity related to cognitive functions such as attention allocation and information processing. Nine diurnally active healthy male subjects whose sleep-wake rhythms were synchronized prior to the experiment were studied. The P300 components oral temperature, heart rate, left- and right-hand grip strength, reaction time, subjectively rated sleepiness, attention level, and fatigue were measured at 08:00, 11:00, 14:00, 17:00, and 20:00. Significant diurnal variations in P300 latency, P300 amplitude, oral temperature, heart rate, left- and right-hand grip strength, subjectively rated sleepiness, and attention level were observed. The P300 latency at 08:00 was significantly longer than at 11:00, 17:00, and 20:00, while the P300 amplitude at 08:00 was significantly greater than at 17:00 and 20:00. The P300 latency was correlated positively with subjectively rated sleepiness and negatively correlated with subjectively rated attention level. These results suggest the existence of diurnal variation in human cognitive functions.
Higuchi
S
S
Department of Public Health, Akita University School of Medicine, Akita City, Japan. higuchi@med.akita-u.ac.jp
Liu
Y
Y
Yuasa
T
T
Maeda
A
A
Motohashi
Y
Y
D000328:Adult; D001288:Attention / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005221:Fatigue / Q000503:physiopathology; D018737:Hand Strength / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology