Riluzole and methylprednisolone combined treatment improves functional recovery in traumatic spinal cord injury.
The potential use of riluzole (a glutamate release inhibitor) alone or in combination with methyl-prednisolone (MP) in treating acute spinal cored injury (SCI) was examined. Rats received a contusion injury to the spinal cord using the NYU impactor and were treated with vehicle, riluzole (8 mg/kg), MP(30 mg/kg), or riluzole + MP at 2 and 4 h following injury. Animals continued to receive riluzole treatment (8 mg/kg) for a period of 1 week. The animals were then tested weekly for functional recovery using the BBB open field locomotor score. At the end of testing (6 weeks after injury), each spinal cord was examined for the amount of remaining tissue at the injury site and a myelination index was used to quantify remaining axons in the ventromedial white matter. In this study, only the combination treatment was found to significantly improve behavioral recovery as assessed using the BBB open field locomotor scale. In addition, the combination treatment promoted tissue sparing at the lesion epicenter, but had no clear effect on the index of myelination. The results of this study clearly demonstrate the potential beneficial effects of a combination approach in the treatment of traumatic SCI.
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Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington 40536-0084,USA.
Azbill
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Springer
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D000818:Animals; D004359:Drug Therapy, Combination; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D020233:Gait Disorders, Neurologic / Q000188:drug therapy / Q000473:pathology / Q000534:rehabilitation; D005938:Glucocorticoids / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism; D008124:Locomotion / Q000187:drug effects; D008775:Methylprednisolone / Q000494:pharmacology*; D009186:Myelin Sheath / Q000473:pathology / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D020127:Recovery of Function / Q000187:drug effects; D019782:Riluzole / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology / Q000534:rehabilitation
D018691:Excitatory Amino Acid Antagonists; D005938:Glucocorticoids; D018698:Glutamic Acid; D019782:Riluzole; D008775:Methylprednisolone