Aryl H-phosphonates. 12. Synthetic and (31)P NMR studies on the preparation of nucleoside H-phosphonothioate and nucleoside H-phosphonodithioate monoesters.
Transformation of nucleoside H-phosphonate monoesters into the corresponding H-phosphonothioate and H-phosphonodithioate derivatives and possible side-reactions that may accompany this process were studied using (31)P NMR spectroscopy. These provided new insight into a possible mechanism involved in this transformation and constituted the basis for development of efficient methods for the preparation of nucleoside H-phosphonothioate and nucleoside H-phosphonodithioate monoesters using readily available H-phosphonate monoesters as starting materials.
Cieślak
J
J
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznań, Poland.
Jankowska
J
J
Stawiński
J
J
Kraszewski
A
A
D004952:Esters; D006862:Hydrogen Sulfide; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D017646:Organosilicon Compounds / Q000737:chemistry; D013872:Thionucleosides / Q000138:chemical synthesis*
D004952:Esters; D007202:Indicators and Reagents; D017646:Organosilicon Compounds; D013872:Thionucleosides; D006862:Hydrogen Sulfide