Reorganization of primary motor cortex in adult macaque monkeys with long-standing amputations.
The organization of primary motor cortex (M1) of adult macaque monkeys was examined years after therapeutic amputation of part of a limb or digits. For each case, a large number of sites in M1 were electrically stimulated with a penetrating microelectrode, and the evoked movements and levels of current needed to evoke the movements were recorded. Results from four monkeys with the loss of a forelimb near or above the elbow show that extensive regions of cortex formerly devoted to the missing hand evoked movements of the stump and the adjoining shoulder. Threshold current levels for stump movements were comparable to those for normal arm movements. Few or no sites in the estimated former territory of the hand evoked face movements. Similar patterns of reorganization were observed in all four cases, which included two monkeys injured as adults, one as a juvenile, and one as an infant. In a single monkey with a hindlimb amputation at the knee as an infant, stimulation of cortex in the region normally devoted to the foot moved the leg stump, again at thresholds in the range for normal movements. Finally, in a monkey that had lost digit 5 and the distal phalanges of digits 2-4 at 2 yr of age, much of the hand portion of M1 was devoted to movements of the digit stumps.
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Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA.
Stepniewska
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Kaas
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D000671:Amputation, Surgical; D000672:Amputation Stumps / Q000294:innervation; D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D005121:Extremities / Q000293:injuries* / Q000294:innervation / Q000601:surgery; D005260:Female; D008251:Macaca; D008253:Macaca mulatta; D008254:Macaca nemestrina; D008297:Male; D009044:Motor Cortex / Q000503:physiopathology*; D009068:Movement; D009473:Neuronal Plasticity; D012016:Reference Values; D013997:Time Factors; D014947:Wounds and Injuries / Q000601:surgery* / Q000662:veterinary*