title: Failure to detect circulating Aspergillus markers in a patient with chronic granulomatous disease and invasive aspergillosis.
abstract: We report a patient with chronic granulomatous disease who developed invasive pulmonary aspergillosis and a subphrenic abscess. During treatment, high levels of Aspergillus antigen were detected in the abscess, but circulating antigen and Aspergillus DNA were undetectable in the serum.
authors.affiliation: Department of Medical Microbiology, University Medical Center Nijmegen, Nijmegen, The Netherlands. p.verweij@mmb.azn.nl
authors.forename: P E
authors.initials: PE
authors.lastname: Verweij
authors.forename: C M
authors.initials: CM
authors.lastname: Weemaes
authors.forename: J H
authors.initials: JH
authors.lastname: Curfs
authors.forename: S
authors.initials: S
authors.lastname: Bretagne
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D001230:Aspergillus / Q000302:isolation & purification*; D001707:Biopsy, Needle; D002675:Child, Preschool; D004271:DNA, Fungal / Q000097:blood; D003951:Diagnostic Errors; D005690:Galactose / Q000031:analogs & derivatives; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008169:Lung Abscess / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008351:Mannans / Q000097:blood; D011743:Pyrimidines / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D008351:Mannans; D011743:Pyrimidines; D014230:Triazoles; C012990:galactomannan; D017964:Itraconazole; D065819:Voriconazole; D005690:Galactose