Cytokine-induced differentiation and proliferation of human T lymphocytes in vitro: effects of interleukin 2 and interleukin 6.
The contents of CD8(+), CD4(+)CD8(+), CD3(+)HLA-DR(+), CD8(+)INF-gamma (+) T cells, and natural killers (CD16(+)56(+)) and NK/T cells (CD16(+)56(+)CD3(+)) increase after 7-day culturing in the presence of interleukin-2. The number of apoptotic cells and cells in S-, and G(2)+M phases of the cell cycle also increased. Interleukin-6 predominantly induced proliferation of CD3(+)HLA-DR(+) T cells and G(2)+M mitotic cells.
Smol'nikova
V V
VV
Institute of Hematology and Hemotransfusion, Ministry of Health of the Belorussia Republic.
Voznyuk
A V
AV
Potapnev
M P
MP
D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D002478:Cells, Cultured; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007376:Interleukin-2 / Q000494:pharmacology*; D015847:Interleukin-4 / Q000378:metabolism; D015850:Interleukin-6 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D007376:Interleukin-2; D015850:Interleukin-6; D015847:Interleukin-4; D007371:Interferon-gamma