title: Liver transplantation from controlled non-heart-beating donors.
abstract: BACKGROUND
  The use of organs from non-heart-beating donors (NHBDs) has been proposed as one way to increase the donor pool. However, few centers have transplanted livers from NHBDs. We report here the results of 19 liver transplants from controlled NHBDs.
  
  
  METHODS
  From January 1993 through August 1999, 364 liver transplantations were performed from heart-beating donors (HBDs) and 19 liver transplantations were performed from NHBDs. Donor and recipient characteristics, posttransplant complications, and patient and allograft survival were compared.
  
  
  RESULTS
  No differences in hepatic artery, portal vein, or biliary complications were noted between the groups. However, the rate of primary nonfunction was higher in recipients of livers from NHBDs (10.5% vs. 1.3%; P = .04). No difference in patient survival was seen between recipients of NHBDs or HBDs (72.6% vs. 84.8%; P =.36); however, allograft survival was lower in recipients who received livers from NHBDs (53.8% vs. 80.9%; P =.007).
  
  
  CONCLUSIONS
  Liver transplantation from controlled NHBDs results in similar patient survival and post-transplant complications. However, primary nonfunction was higher and allograft survival was less in recipients of livers from NHBDs. The results of liver transplantation from controlled NHBDs are encouraging and should continue to be cautiously pursued as one way to help alleviate the current shortage of donor livers.
authors.affiliation: Department of Surgery, Division of Organ Transplantation, University of Wisconsin Medical School, Madison, Wis. 53792-7375, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: D'alessandro
authors.forename: R M
authors.initials: RM
authors.lastname: Hoffmann
authors.forename: S J
authors.initials: SJ
authors.lastname: Knechtle
authors.forename: J S
authors.initials: JS
authors.lastname: Odorico
authors.forename: Y T
authors.initials: YT
authors.lastname: Becker
authors.forename: A
authors.initials: A
authors.lastname: Musat
authors.forename: J D
authors.initials: JD
authors.lastname: Pirsch
authors.forename: H W
authors.initials: HW
authors.lastname: Sollinger
authors.forename: M
authors.initials: M
authors.lastname: Kalayoglu
mesh_terms: D000328:Adult; D000368:Aged; D016913:Blood Component Transfusion / Q000706:statistics & numerical data; D002102:Cadaver; D005260:Female; D006084:Graft Rejection / Q000401:mortality; D006085:Graft Survival; D006801:Humans; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011183:Postoperative Complications / Q000401:mortality; D016019:Survival Analysis; D009927:Tissue and Organ Procurement / Q000379:methods*