Colorectal cancer update. Prevention, screening, treatment, and surveillance for high-risk groups.
Great advances have been made in understanding the cause and molecular genesis of colorectal cancer. The disease can be prevented by a healthful diet and lifestyle or by resecting the precursor of most of these cancers, the advanced adenomatous polyp. Screening the average-risk population plus special surveillance for high-risk groups now is recommended by evidence-based guidelines. Surgery is highly curative for patients without distant metastases, and adjuvant therapy improves survival in selected patients with advanced cancers.
Bond
J H
JH
Gastroenterology Section, Minneapolis VA Medical Center, Minnesota, USA.
D018256:Adenomatous Polyps / Q000601:surgery; D003110:Colonic Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control* / Q000601:surgery / Q000628:therapy; D003111:Colonic Polyps / Q000601:surgery; D004032:Diet; D019317:Evidence-Based Medicine; D006801:Humans; D008019:Life Style; D008403:Mass Screening; D008967:Molecular Biology; D020360:Neoadjuvant Therapy; D011159:Population Surveillance; D017410:Practice Guidelines as Topic; D011230:Precancerous Conditions / Q000601:surgery; D012004:Rectal Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control* / Q000601:surgery / Q000628:therapy; D012307:Risk Factors