Total synthesis of (+)-crocacin C.
The first asymmetric synthesis of (+)-crocacin C (3) is described which served to confirm the absolute configuration of this compound. The key step in the sequence was the stereoselective assembly of the (E,E)-diene amide side chain by a Stille cross-coupling between the stannane 5 and vinyl iodide 6.
Feutrill
J T
JT
School of Chemistry, The University of Melbourne, Victoria 3010, Australia.
Lilly
M J
MJ
Rizzacasa
M A
MA
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D011090:Polyenes / Q000138:chemical synthesis / Q000737:chemistry
D000935:Antifungal Agents; D011090:Polyenes; C089608:crocacin