[Dantrolene-induced pleurisy: a case report].
We report the case of a patient who developed dantrolene-induced pleurisy. Dantrolene (Dantrium) is a muscle relaxing agent used for the treatment of spastic neurological manifestations which has known liver toxicity. Lung toxicity is rarely reported. Six cases of dantrolene-induced pleurisy occurring after chronic administration (> 60 days) have been described in the literature. The pleurisy is associated with pleural and peripheral eosinophilia. Spontaneous regression a few days after withdrawal and radiological cure a few months later is the rule. The precise mechanism of this drug-induced pleural reaction remains unknown.
Dohen
F
F
Service de Pneumologie, Centre Hospitalier de Dunkerque 130, avenue Louis Herbeaux, B.P. 6.367, 59385 Dunkerque Cedex.
Montagne
V
V
Lelieur
E
E
D000368:Aged; D003620:Dantrolene / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D009128:Muscle Spasticity / Q000188:drug therapy; D010998:Pleurisy / Q000139:chemically induced* / Q000175:diagnosis; D013997:Time Factors
D009125:Muscle Relaxants, Central; D003620:Dantrolene