title: Safety and long-term efficacy of transduodenal excision for tumors of the ampulla of Vater.
abstract: BACKGROUND
  Ampullary tumors should be resected because of the high incidence of malignancy and the unreliability of preoperative endoscopic diagnosis. Controversy exists about whether to perform a transduodenal excision (TDE) or a pancreatoduodenectomy. This study evaluated the safety and long-term efficacy of TDE.
  
  
  METHODS
  The records of 21 patients with a pathologic diagnosis of ampullary adenoma who underwent TDE were reviewed. Demographics, symptoms, pathologic findings, and outcomes were analyzed and long-term follow-up was ascertained.
  
  
  RESULTS
  Twenty-one patients (mean age, 61 years) underwent TDE. Final pathology showed adenoma in all patients including 1 (5%) with invasive cancer, 2 (9%) with microinvasive cancer, 6 (28%) with high-grade dysplasia, and 1 (5%) with low-grade dysplasia. The overall survival was 85% (mean follow-up of 38 months). One of 3 late deaths was likely related to disease progression. Sixteen of the 18 remaining patients (89%) had no evidence of tumor recurrence. One benign ampullary recurrence was successfully treated endoscopically. One additional patient developed an ampullary cancer and underwent pancreatoduodenectomy.
  
  
  CONCLUSIONS
  TDE of benign ampullary tumors, even those with varying grades of dysplasia, can be performed with acceptable morbidity and low rates of recurrence. Postoperative endoscopic surveillance is mandatory to identify recurrent tumors.
authors.affiliation: Division of Gastrointestinal Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA.
authors.forename: S
authors.initials: S
authors.lastname: Posner
authors.forename: L
authors.initials: L
authors.lastname: Colletti
authors.forename: J
authors.initials: J
authors.lastname: Knol
authors.forename: M
authors.initials: M
authors.lastname: Mulholland
authors.forename: F
authors.initials: F
authors.lastname: Eckhauser
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000473:pathology / Q000601:surgery*; D003138:Common Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D019160:Endosonography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D016577:Pancreaticoduodenectomy; D012189:Retrospective Studies; D013105:Sphincterotomy, Transduodenal / Q000379:methods*; D016896:Treatment Outcome