title: Results of retroviral and adenoviral approaches to cancer gene therapy.
abstract: Genetic modification for cancer treatment has involved the introduction of chemotherapy protection and sensitization genes into normal and tumor cells, respectively, for the purpose of improving the outcome of conventional approaches to the treatment of solid tumor neoplasms. This paper will review the use of multidrug resistance-1 retroviral vectors and cytosine deaminase adenoviral prodrug activation vectors for this purpose.
authors.affiliation: Yale Cancer Center, and Department of Internal Medicine of the Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Yin
authors.forename: S Q
authors.initials: SQ
authors.lastname: Fu
authors.forename: T
authors.initials: T
authors.lastname: Nanakorn
authors.forename: F
authors.initials: F
authors.lastname: Garcia-Sanchez
authors.forename: I
authors.initials: I
authors.lastname: Chung
authors.forename: R
authors.initials: R
authors.lastname: Cote
authors.forename: G
authors.initials: G
authors.lastname: Pizzorno
authors.forename: E
authors.initials: E
authors.lastname: Hanania
authors.forename: S
authors.initials: S
authors.lastname: Heimfeld
authors.forename: R
authors.initials: R
authors.lastname: Crystal
authors.forename: A
authors.initials: A
authors.lastname: Deisseroth
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000256:Adenoviridae; D001943:Breast Neoplasms / Q000628:therapy*; D005260:Female; D018014:Gene Transfer Techniques / Q000009:adverse effects; D019450:Genes, MDR; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000628:therapy*; D012190:Retroviridae
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D016179:Granulocyte Colony-Stimulating Factor