Successful pregnancy and birth after IVF in a woman with cystic fibrosis.
As survival increases, patients with cystic fibrosis (CF) are often confronted with reproductive issues. Initial reports gave conflicting advice regarding the outcome of pregnancy in CF. However a recent large longitudinal study of pregnancies in CF women suggested that pregnancy has little impact on morbidity or mortality. Reduced fertility in CF women has been described, possibly due to thickened cervical mucus, and intrauterine insemination (IUI) has been used to overcome this. We report the first woman with CF, to our knowledge, to be successfully treated with IVF after repeated failed attempts at IUI.
Rodgers
H C
HC
Respiratory Medicine Unit, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK.
Knox
A J
AJ
Toplis
P J
PJ
Thornton
S J
SJ
D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications* / Q000235:genetics; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D008297:Male; D009154:Mutation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy