[Microglia--new target cells for neurological therapy].
Disturbances in the normal homeostasis of the central nervous system induce a localized activation of microglia. This activation serves to isolate pathological processes from surrounding, intact nervous tissue. Concomitantly, healthy or minimally damaged nerve cells nearby may be negatively influenced by potent molecules released by activated microglia. This situation appears to exist e.g. in ischemia, multiple sclerosis and Alzheimer's disease. Pharmacologic regulation of microglial activity is therefore a rational approach to treatment of many central nervous system disorders.
Aldskogius
H
H
Institutionen för neurovetenskap, Uppsala biomedicinska centrum, Uppsala universitet. Hakan.Aldskogius@neuro.uu.se
D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D017628:Microglia / Q000187:drug effects; D009103:Multiple Sclerosis / Q000188:drug therapy; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal