The role of cytotoxic T lymphocytes in human T-cell lymphotropic virus type 1 infection.
The vast majority of individuals infected with human T-cell lymphotropic virus type 1 have a strong and persistently activated cytotoxic T lymphocyte response to the virus. Experimental work investigating the effects of human T-cell lymphotropic virus-specific cytotoxic T lymphocytes is conflicting. One significant body of work suggests that specific cytotoxic T lymphocytes are protective and help to reduce the risk of disease. However, another body of work implies that specific cytotoxic T lymphocytes play an important role in the development of disease. Here we use a theoretical model to explore the role of cytotoxic T lymphocytes in persistent infection. A way of reconciling the apparently contradictory data is proposed and experimentally testable predictions are made.
Asquith
B
B
Department of Immunology, Imperial College School of Medicine, St Mary's, Norfolk Place, London, W2 1PG, U.K.
Bangham
C R
CR
D003602:Cytotoxicity, Immunologic / Q000276:immunology; D015490:HTLV-I Infections / Q000276:immunology* / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000254:growth & development; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000276:immunology; D018448:Models, Immunological; D011533:Proviruses / Q000254:growth & development; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D019562:Viral Load
D007371:Interferon-gamma