Biocompatibility correlation of polymeric materials using human osteosarcoma cells.
Metal implants are the preferred materials to generate articular prostheses, plates, or bone pegs in orthopedic surgery. Although titanium and titanium alloys show a relatively good biocompatibility, clinical experience revealed that coating of the metallic implant surface may increase the biocompatibility. In a search for optimum bone implant surfaces, we determined polarity and contact angle parameters of a variety of polymers and substances and correlated the findings in a biocompatibility assay using an in vitro bone cell model. We report that an optimum adherence of SAOS-2 cells to such surfaces and a good vitality for polymers are characterized by water-based contact angles of 80 degrees and 20 degrees for advancing and receding probes, respectively.
Geckeler
K E
KE
Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, University of Tübingen, Germany. keg@kjist.ac.kr
Wacker
R
R
Aicher
W K
WK
D001672:Biocompatible Materials / Q000494:pharmacology*; D005898:Glass; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D012516:Osteosarcoma; D011076:Polycarboxylate Cement / Q000494:pharmacology; D019904:Polymethyl Methacrylate / Q000494:pharmacology; D011137:Polystyrenes / Q000494:pharmacology; D011143:Polyvinyl Chloride / Q000494:pharmacology; D011145:Polyvinyls / Q000494:pharmacology; D019736:Prostheses and Implants; D014407:Tumor Cells, Cultured
D001672:Biocompatible Materials; D011076:Polycarboxylate Cement; D011137:Polystyrenes; D011145:Polyvinyls; C005506:polycarbonate; C013215:polyvinyl acetate; D011143:Polyvinyl Chloride; D019904:Polymethyl Methacrylate