Dissection of c-Mpl and thrombopoietin function: studies of knockout mice and receptor signal transduction.
The physiological roles and mechanisms of action of thrombopoietin (TPO) and its receptor c-Mpl have been studied through the analysis of mice genetically deficient in these molecules, as well as through the dissection of signaling events utilizing chimeric receptors. The evidence clearly demonstrates that the TPO/c-Mpl system provides dominant control in the regulation of megakaryocytopoiesis. The signaling mechanisms that underlie this process appear to be similar to those noted with other members of the hematopoietic cytokine and cytokine receptor families.
Gurney
A L
AL
Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080, USA.
de Sauvage
F J
FJ
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D002460:Cell Line; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009363:Neoplasm Proteins; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; D015398:Signal Transduction; D013926:Thrombopoietin / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*
D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; C082218:MPL protein, human; D013926:Thrombopoietin