title: Short-term motor improvement after sub-threshold 5-Hz repetitive transcranial magnetic stimulation of the primary motor hand area in Parkinson's disease.
abstract: Ten unmedicated patients with Parkinson's disease received sub-threshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over the primary motor hand area (M1(HAND)) contralaterally to the more affected upper limb. Compared to a midfrontal sham-rTMS, real-rTMS over M1(HAND) was associated with a significant decrease in the global motor UPDRS score 1 h after the cessation of rTMS. This was mainly due to a clinical improvement in the arm contralaterally to the stimulated M1(HAND). These preliminary data suggest that focal rTMS of M1(HAND) may have a therapeutic potential in PD.
authors.affiliation: Department of Neurology, Technische Universität München, Moehlstrasse 28, D-81675, Munich, Germany. hartwig.siebner@neuro.medmtu-muenchen.de
authors.forename: H R
authors.initials: HR
authors.lastname: Siebner
authors.forename: C
authors.initials: C
authors.lastname: Rossmeier
authors.forename: C
authors.initials: C
authors.lastname: Mentschel
authors.forename: A
authors.initials: A
authors.lastname: Peinemann
authors.forename: B
authors.initials: B
authors.lastname: Conrad
mesh_terms: D004574:Electromagnetic Fields; D007839:Functional Laterality; D006225:Hand; D006801:Humans; D008875:Middle Aged; D009043:Motor Activity; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D050781:Transcranial Magnetic Stimulation / Q000627:therapeutic use*