Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children.
Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response.
Nurkka
A
A
Department of Vaccines, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland. anu.nurkka@ktl.fi
MacLennan
J
J
Jäntti
V
V
Obaro
S
S
Greenwood
B
B
Käyhty
H
H
D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D002675:Child, Preschool; D005714:Gambia; D006801:Humans; D018928:Immunity, Mucosal; D007115:Immunization Schedule; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis* / Q000097:blood; D007156:Immunologic Memory; D022401:Meningococcal Vaccines / Q000008:administration & dosage*; D009345:Neisseria meningitidis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D012463:Saliva / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000008:administration & dosage
D000907:Antibodies, Bacterial; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial; D018074:Vaccines, Conjugate