title: Advances in three-dimensional reconstruction of the experimental spinal cord injury.
abstract: Three-dimensional (3D) computer reconstruction is an ideal tool for evaluating the centralized pathology of mammalian spinal cord injury (SCI) where multiple anatomical features are embedded within each other. Here, we evaluate three different reconstruction algorithms to three-dimensionally visualize SCIs. We also show for the first time, that determination of the volume and surface area of pathological features is possible using the reconstructed 3D images themselves. We compare these measurements to those calculated by older morphometric approaches. Finally, we demonstrate dynamic navigation into a 3D spinal cord reconstruction.
authors.affiliation: Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research, Purdue University, 1244 VCPR West Lafayette, IN 47907-1244, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Duerstock
authors.forename: C L
authors.initials: CL
authors.lastname: Bajaj
authors.forename: V
authors.initials: V
authors.lastname: Pascucci
authors.forename: D
authors.initials: D
authors.lastname: Schikore
authors.forename: K N
authors.initials: KN
authors.lastname: Lin
authors.forename: R B
authors.initials: RB
authors.lastname: Borgens
mesh_terms: D000818:Animals; D021621:Imaging, Three-Dimensional; D018715:Microscopy, Video; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000473:pathology*