title: Electrospray ionization mass spectra of amino acid phosphoramidates of adenosine.
abstract: Amino acid phosphoramidates of adenosine were synthesized and determined by positive and negative ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). The fragmentation pathways were investigated. In the positive ion mass spectra abundant characteristic fragment ions appeared, and many complementary ions were found. In the negative ion mass spectra only a few fragment ions were observed, and most of them contained phosphoryl groups. The results show that ESI-MS is a useful tool for structural determination of amino acid phosphoramidates of nucleosides.
authors.affiliation: State Laboratory of Bioorganic Phosphorus Chemistry of Education Ministry, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084, P.R. China.
authors.forename: H
authors.initials: H
authors.lastname: Fu
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: Q
authors.initials: Q
authors.lastname: Lv
authors.forename: J Z
authors.initials: JZ
authors.lastname: Wang
authors.forename: H Z
authors.initials: HZ
authors.lastname: Xiao
authors.forename: Y F
authors.initials: YF
authors.lastname: Zhao
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010766:Phosphorylation
chemical_list: D000577:Amides; D000596:Amino Acids; D009943:Organophosphorus Compounds; D000241:Adenosine