title: [Intraperitoneal perfusion of perftoran in the treatment of patients with diffuse purulent peritonitis].
abstract: For higher efficacy of general purulent peritonitis treatment, intraperitoneal perfusion of Perftoran emulsion was proposed. The drug was administered as a single dose of 100-150 ml before wound suturing. In 48 hours an increase of phagocytizing cells fraction in peritoneal exudate and their higher functional activity was revealed: the phagocytic activity and phagocytic index was 2 times higher than in the control group, complete phagocytosis index--1.5 times higher. Significant reduction of microbial contamination in abdominal cavity was also revealed: in 48 hours there were less aerobic bacteria than in the control group, there were no anaerobic bacteria, or anaerobes were detected in a minimum quantity. Local use of Perftoran allowed to decrease the rate of repeated peritoneal sanitation by 44.4% and to decrease mortality by 5.2%.
authors.forename: G R
authors.initials: GR
authors.lastname: Askerkhanov
authors.forename: A M
authors.initials: AM
authors.lastname: Golubev
authors.forename: A G
authors.initials: AG
authors.lastname: Guseĭnov
authors.forename: V V
authors.initials: VV
authors.lastname: Moroz
authors.forename: U Z
authors.initials: UZ
authors.lastname: Zagirov
mesh_terms: D001419:Bacteria / Q000302:isolation & purification; D001802:Blood Substitutes / Q000008:administration & dosage*; D005122:Exudates and Transudates / Q000382:microbiology; D005466:Fluorocarbons / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D007430:Intraoperative Care; D010529:Peritoneal Cavity / Q000382:microbiology; D010538:Peritonitis / Q000382:microbiology / Q000601:surgery*; D010587:Phagocytosis; D013492:Suppuration
chemical_list: D001802:Blood Substitutes; D005466:Fluorocarbons; C063334:perftoran