title: MR coronary angiography with breath-hold targeted volumes: preliminary clinical results.
abstract: OBJECTIVE
  To assess the clinical value of a magnetic resonance (MR) coronary angiography strategy involving a small targeted volume to image one coronary segment in a single breath hold for the detection of greater than 50% stenosis.
  
  
  METHODS
  Thirty-eight patients referred for elective coronary angiography were included. The coronary arteries were localized during single-breath-hold, three-dimensional imaging of the entire heart. MR coronary angiography was then performed along the major coronary branches with a double-oblique, three-dimensional, gradient-echo sequence. Conventional coronary angiography was the reference-standard method.
  
  
  RESULTS
  Adequate visualization was achieved with MR coronary angiography in 85%-91% of the proximal coronary arterial branches and in 38%-76% of the middle and distal branches. Overall, 187 (69%) of 272 segments were suitable for comparison between conventional and MR coronary angiography. The diagnostic accuracy of MR coronary angiography for the detection of hemodynamically significant stenoses was 92%; sensitivity, 68%; and specificity, 97%. The sensitivity in individual segments was 50%-77%, whereas the specificity was 94%-100%.
  
  
  CONCLUSIONS
  Adequate visualization of the major coronary arterial branches was possible in the majority of patients. The observed accuracy of MR coronary angiography for detection of hemodynamically significant coronary arterial stenosis is promising, but it needs to be higher before this modality can be used reliably in a clinical setting.
authors.affiliation: Departments of Cardiology, Thoraxcenter, and Radiology, Daniel den Hoed Kliniek, University Hospital Rotterdam, Groene Hilledijk 301, 3075 EA Rotterdam, the Netherlands. vangeuns@card.azr.nl
authors.forename: R J
authors.initials: RJ
authors.lastname: van Geuns
authors.forename: P A
authors.initials: PA
authors.lastname: Wielopolski
authors.forename: H G
authors.initials: HG
authors.lastname: de Bruin
authors.forename: B J
authors.initials: BJ
authors.lastname: Rensing
authors.forename: M
authors.initials: M
authors.lastname: Hulshoff
authors.forename: P M
authors.initials: PM
authors.lastname: van Ooijen
authors.forename: P J
authors.initials: PJ
authors.lastname: de Feyter
authors.forename: M
authors.initials: M
authors.lastname: Oudkerk
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity