title: Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
abstract: Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.
authors.affiliation: Howard Hughes Medical Institute, The University of Chicago, Chicago, Illinois, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Horikawa
authors.forename: N
authors.initials: N
authors.lastname: Oda
authors.forename: N J
authors.initials: NJ
authors.lastname: Cox
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Orho-Melander
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Hinokio
authors.forename: T H
authors.initials: TH
authors.lastname: Lindner
authors.forename: H
authors.initials: H
authors.lastname: Mashima
authors.forename: P E
authors.initials: PE
authors.lastname: Schwarz
authors.forename: L
authors.initials: L
authors.lastname: del Bosque-Plata
authors.forename: Y
authors.initials: Y
authors.lastname: Horikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Oda
authors.forename: I
authors.initials: I
authors.lastname: Yoshiuchi
authors.forename: S
authors.initials: S
authors.lastname: Colilla
authors.forename: K S
authors.initials: KS
authors.lastname: Polonsky
authors.forename: S
authors.initials: S
authors.lastname: Wei
authors.forename: P
authors.initials: P
authors.lastname: Concannon
authors.forename: N
authors.initials: N
authors.lastname: Iwasaki
authors.forename: J
authors.initials: J
authors.lastname: Schulze
authors.forename: L J
authors.initials: LJ
authors.lastname: Baier
authors.forename: C
authors.initials: C
authors.lastname: Bogardus
authors.forename: L
authors.initials: L
authors.lastname: Groop
authors.forename: E
authors.initials: E
authors.lastname: Boerwinkle
authors.forename: C L
authors.initials: CL
authors.lastname: Hanis
authors.forename: G I
authors.initials: GI
authors.lastname: Bell
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D002154:Calpain / Q000737:chemistry / Q000235:genetics*; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D005387:Finland; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D015894:Genome, Human; D006239:Haplotypes; D006801:Humans; D017058:Mexican Americans / Q000235:genetics; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D014481:United States; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers; D002154:Calpain; C415197:calpain 10