Benefits and challenges of hormone replacement therapy.
HRT provides both prevention and treatment of osteoporosis. HRT is most likely beneficial in primary prevention of heart disease, and may have a role in preventing Alzheimer's disease and colon cancer. Prospective trials, such as the Women's Health Initiative, are needed to substantiate both benefits and risks. Decisions regarding HRT, as well as nonhormonal regimens, should be individualized.
Borgelt
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L
Shenandoah University School of Pharmacy, Winchester, Va., USA.
Umland
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E
D000368:Aged; D001943:Breast Neoplasms / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000517:prevention & control; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D018570:Risk Assessment