The relationship between angiotensinogen gene CD235 met-->Thr substitution polymorphism and brain infarction in Chinese.
OBJECTIVE
To detect the relationship between angiotensinogen (AGT) gene CD235 Met-->Thr substitution polymorphism and brain infarction.


METHODS
The CD235Met-->Thr substitution polymorphism in exon 2 of AGT gene was analyzed in normal group(82 cases) and brain infarction group (102 cases) by a combination of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).


RESULTS
Between the control group and brain infarction group, chi-square test showed no significant difference in the frequencies of T/T genotype and T allele (P>0.05). However, the frequencies of T/T genotype and T allele (70.6% and 83.8%) for multiple brain infarction patients were higher than those (42.6% and 65.2%) for lacunae brain infarction patients and those (42.0% and 65.2%) for controls (P<0.01). The frequencies of AGT T/T genotype and T allele (65.3% and 78.6%) for patients with brain infarction associated with hypertension were higher than those (42.0% and 65.0%) for patients with brain infarction not associated with hypertension (P<0.05).


CONCLUSIONS
No direct relationship between AGT CD235 Met-->Thr substitution polymorphism and ordinary brain infarction has been observed, but there is a significant correlation between AGT gene T/T genotype and multiple brain infarction, and brain infarction associated with hypertension too.
Guan
L
L
Weifang People's Hospital, Weifang, Shandong, 261041 P.R.China. guan373@public.wf.sd.cn
Zhang
A
A
Song
B
B
Xiao
S
S
Gao
Y
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D002544:Cerebral Infarction / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D000808:Angiotensinogen