Antinociceptive activity of a hydroalcoholic extract obtained from aerial parts of Sebastiania schottiana (Euphorbiaceae).
This study analyzed the antinociceptive effects of a hydroalcoholic extract obtained from the aerial parts of Sebastiania schottiana, a Brazilian medicinal plant used to treat various painful diseases. For this purpose, the writhing test, capsaicin and formalin induced-pain in mice were used. The results showed that the hydroalcoholic extract exhibited considerable antinociception in all the models studied, being more potent than aspirin.
Luzzi
R
R
Núcleo de Investigações Químico Farmacĕuticas (NIQFAR), Curso de Farmácia/CCS, Universidade do Vale do Itajaí (UNIVALI), SC, Brazil.
Scheidt
C
C
Roos
J F
JF
Cechinel Filho
V
V
Santos
A R
AR
Calixto
J B
JB
Yunes
R A
RA
Niero
R
R
D000085:Acetates; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002211:Capsaicin; D019665:Euphorbiaceae / Q000737:chemistry*; D005557:Formaldehyde; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000187:drug effects; D018547:Plant Stems / Q000187:drug effects
D000085:Acetates; D000700:Analgesics; D010936:Plant Extracts; D005557:Formaldehyde; D002211:Capsaicin