title: Vitrectomy for diffuse diabetic macular edema associated with a taut premacular posterior hyaloid.
abstract: OBJECTIVE
  To evaluate the role of vitrectomy in eyes with diffuse diabetic macular edema associated with a taut posterior hyaloid.
  
  
  METHODS
  Records of 55 eyes of 50 patients with diabetic retinopathy and diffuse clinically significant diabetic macular edema who underwent vitrectomy with stripping of the premacular posterior hyaloid were reviewed. In all 55 eyes, diffuse diabetic macular edema was present on contact lens examination and confirmed with fluorescein angiography. On fundus examination, the premacular posterior hyaloid was attached and appeared taut.
  
  
  RESULTS
  The mean preoperative best-corrected visual acuity was 20/160, and the mean final best-corrected visual acuity was 20/80 (P <.0001, Wilcoxon signed rank test), with 27 (49.1%) of the 55 eyes demonstrating improvement in best-corrected visual acuity of 2 or more lines. Fifty-two (94.5%) of the 55 vitrectomized eyes showed improvement in clinically significant macular edema and in 45 eyes (81.8%) the macular edema resolved completely during a mean period of 4.5 months (range, 1 to 13 months). Eyes with macular ischemia and preoperative best-corrected visual acuity of 20/200 or less tended to respond less favorably to vitrectomy than eyes lacking these characteristics. All eyes had at least 6 months of follow-up after surgery, with a mean follow-up of 23.2 months.
  
  
  CONCLUSIONS
  In eyes with persistent diffuse diabetic macular edema with a taut premacular posterior hyaloid face unresponsive to laser therapy, vitrectomy with removal of the posterior hyaloid appears to be beneficial in some cases. Careful selection of eyes with favorable preoperative clinical characteristics may improve surgical outcomes.
authors.affiliation: Retina Associates of Cleveland, Inc, Beachwood, Ohio 44122, USA. Spender0@aol.com
authors.forename: S D
authors.initials: SD
authors.lastname: Pendergast
authors.forename: T S
authors.initials: TS
authors.lastname: Hassan
authors.forename: G A
authors.initials: GA
authors.lastname: Williams
authors.forename: M S
authors.initials: MS
authors.lastname: Cox
authors.forename: R R
authors.initials: RR
authors.lastname: Margherio
authors.forename: P J
authors.initials: PJ
authors.lastname: Ferrone
authors.forename: B R
authors.initials: BR
authors.lastname: Garretson
authors.forename: M T
authors.initials: MT
authors.lastname: Trese
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000473:pathology; D003930:Diabetic Retinopathy / Q000473:pathology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D017075:Laser Coagulation; D008269:Macular Edema / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology*