Biomedicine. Staying slim with insulin in mind.
Striking the delicate balance between energy intake in the form of food and energy expenditure in the form of metabolic activity keeps the body extremely busy. As Schwartz explains in his enlightening Perspective, the finding that insulin signals the brain to promote weight loss (Brüning et al.) flies in the face of the notion that insulin is involved solely in glucose storage, its conversion to fat, and weight gain.
Schwartz
M W
MW
Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98105, USA. mschwart@u.washington.edu
D017667:Adipocytes / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D001921:Brain / Q000502:physiology*; D004435:Eating; D005260:Female; D007328:Insulin / Q000502:physiology*; D020738:Leptin / Q000502:physiology; D008297:Male; D051379:Mice; D009474:Neurons / Q000502:physiology; D009765:Obesity / Q000209:etiology; D011972:Receptor, Insulin / Q000502:physiology*; D015398:Signal Transduction; D015431:Weight Loss
D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D011972:Receptor, Insulin