[Relationship between tumor recurrence and the expression of the p53 gene in primary superficial transitional carcinoma of the bladder].
Contribution of 60 patients with primary surface transitional cell tumours of the bladder where nuclear expression of p53 protein was prospectively studied and compared to known prognostic factors in an attempt to find out its role in the development of relapses. An statistically significant relationship was found between the protein expression and cytology, tumoral multifocality, stage, relapse development and tumoral progression. It can be concluded that expression of this protein can be of use as relapse predictor.
Menéndez López
V
V
Servicio de Urología, Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, Alicante.
Molina Porto
R
R
Alcaraz Asensio
A
A
Gutiérrez del Pozo
R
R
Alcover García
J A
JA
D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D011446:Prospective Studies; D001749:Urinary Bladder Neoplasms / Q000235:genetics*