Recent advances in candidate selection for pediatric epilepsy surgery.
Many patients who were once considered inoperable are candidates for a wide variety of surgical procedures. This trend is particularly striking at pediatric centers that serve patients with diverse forms of epilepsy that compromise development. Newer diagnostic techniques, including structural and functional imaging, EEG monitoring, and surgical technology, can provide a complete representation of the etiology and expression of the epileptic focus, including accurate cortical localization. This review focuses on several forms of epilepsy that, until recently, were not regarded to be surgically amenable. The adverse seizure and neurobehavioral prognosis in patients with these disorders provides the justification to search for innovative treatments. With more sophisticated tools for preoperative evaluation and an expanding knowledge base, it is likely that the number of surgical candidates will continue to increase in the future.
Duchowny
M
M
Department of Neurology, Miami Children's Hospital, Miami, FL 33155, USA.
D001921:Brain / Q000002:abnormalities / Q000473:pathology / Q000601:surgery*; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000601:surgery; D002648:Child; D003937:Diagnosis, Differential; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000601:surgery; D004827:Epilepsy / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis / Q000601:surgery; D019635:Neurosurgical Procedures / Q000639:trends*; D018579:Patient Selection; D013036:Spasms, Infantile / Q000175:diagnosis / Q000601:surgery; D016896:Treatment Outcome; D014402:Tuberous Sclerosis / Q000175:diagnosis / Q000601:surgery