title: Recombinant FVIIa (NovoSeven) continuous infusion and total hip replacement in patients with haemophilia and high titre of inhibitors to FVIII: experience of two cases.
abstract: In this report we describe our experience of total hip replacement in two patients with severe haemophilia A and high titres of inhibitors to FVIII. We used rFVIIa replacement therapy by continuous infusion to perform the surgery. The total amount of rFVIIa used in these two patients was very similar but the manner of administration was quite different. In our experience, it is an advantage to use a higher dose for shorter periods than a lower dose for a longer treatment period. Tranexamic acid by continuous infusion, and parallel saline infusion were useful for good haemostasis and avoided local thrombophlebitis in the side of rFVIIa infusion.
authors.affiliation: Servizio Trasfusionale, Centro per le Malattie del Sangue e Servizio di assistenza agli Emofilici, Castelfranco Veneto Hospital (TV), ASL 8 Regione Veneto, Italy. tagariello@ulssasolo.ven.it
authors.forename: G
authors.initials: G
authors.lastname: Tagariello
authors.forename: E
authors.initials: E
authors.lastname: De Biasi
authors.forename: G B
authors.initials: GB
authors.lastname: Gajo
authors.forename: R
authors.initials: R
authors.lastname: Risato
authors.forename: P
authors.initials: P
authors.lastname: Radossi
authors.forename: P G
authors.initials: PG
authors.lastname: Davoli
authors.forename: A
authors.initials: A
authors.lastname: Traldi
mesh_terms: D000328:Adult; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000379:methods; D016063:Blood Loss, Surgical / Q000517:prevention & control; D005169:Factor VIII / Q000009:adverse effects / Q000276:immunology*; D015942:Factor VIIa / Q000008:administration & dosage*; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D007518:Isoantibodies / Q000097:blood; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage; D014148:Tranexamic Acid / Q000008:administration & dosage
chemical_list: D007518:Isoantibodies; D011994:Recombinant Proteins; D012965:Sodium Chloride; D014148:Tranexamic Acid; D005169:Factor VIII; D015942:Factor VIIa