Xenopus cadherin-6 is expressed in the central and peripheral nervous system and in neurogenic placodes.
We have cloned the cDNAs encoding the two Xenopus laevis cadherin-6 pseudoalleles (Xcad-6 and Xcad-6'), which belong to the classical type II cadherin subfamily. During embryogenesis, Xcad-6 expression starts at early neurula and increases dramatically until tadpole stages. Whole-mount in situ hybridization revealed that the transcripts are localized in the developing brain and eye. However, most prominent expression was found in the peripheral nervous system, including a major proportion of lateral line structures. Our results implicate an important contribution of cadherin-6 to the formation of placode derived nerves in Xenopus, an observation which has not been described for other species.
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Abt. Biochemie, Universität Ulm, Albert-Einstein-Allee 11, D-89081, Ulm, Germany. robert.david@medizin.uni-ulm.de
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015820:Cadherins / Q000235:genetics*; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism*; D018076:DNA, Complementary; D015870:Gene Expression; D008969:Molecular Sequence Data; D017933:Peripheral Nervous System / Q000196:embryology / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D014982:Xenopus laevis
D015820:Cadherins; D018076:DNA, Complementary; C087310:K cadherin