title: Oral involvement in mycosis fungoides: report of two cases and a literature review.
abstract: Oral involvement is uncommon in cutaneous T-cell lymphomas and usually associated with poor prognosis. The clinicopathological and immunohistochemical findings of 2 new cases are described along with a literature review. The first patient had a 10-year history of mycosis fungoides when she developed lesions in the oral tissues. She died 6 months later despite treatment. The immunophenotype was CD3+, CD4+, CD8-, CD30-. The second patient had a mycosis fungoides for 5 years when she developed lesions in the uvula and oropharynx. She was treated with polychemotherapy and she is alive 5 years after oral involvement. The immunophenotype was CD3+, CD4-, CD8+, CD30-. There are conflicting reports about the prognosis in the CD8+ phenotype. The present cases and the literature review seem to indicate that in oral involvement the CD8- phenotype is not associated with a worse prognosis than the CD4+ subtype. However, it is necessary to study new cases to confirm this statement.
authors.affiliation: Department of Dermatology, 12 de Octubre University Hospital, Madrid, Spain.
authors.forename: E G
authors.initials: EG
authors.lastname: de la Fuente
authors.forename: J L
authors.initials: JL
authors.lastname: Rodriguez-Peralto
authors.forename: P L
authors.initials: PL
authors.lastname: Ortiz
authors.forename: N
authors.initials: N
authors.lastname: Barrientos
authors.forename: F
authors.initials: F
authors.lastname: Vanaclocha
authors.forename: L
authors.initials: L
authors.lastname: Iglesias
mesh_terms: D000368:Aged; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000556:secondary*; D009182:Mycosis Fungoides / Q000473:pathology*; D009959:Oropharyngeal Neoplasms / Q000556:secondary; D012878:Skin Neoplasms / Q000473:pathology*; D014062:Tongue Neoplasms / Q000556:secondary; D014609:Uvula
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens