title: [Drug therapy for nocturnal gastric acid breakthrough].
abstract: Nocturnal gastric acid breakthrough(NAB) is defined as nighttime periods of over 1 hour duration, with a gastric pH < 4.0, during administration of a proton pump inhibitor(PPI). Although the causative mechanism of NAB is unclear, this phenomenon is a serious problem for patients with high grade reflux esophagitis. NAB is more frequently observed in patients with reflux esophageals, since this phenomenon is mainly observed in cases without H. pylori infection. Bedtime administration of H2 receptor antagonist rather than additional administration of PPI on the standard dose of PPI is effective for the control of NAB.
authors.affiliation: Shimane Medical University, Department of Medicine II.
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Adachi
mesh_terms: D000863:Antacids / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D004942:Esophagitis, Peptic / Q000188:drug therapy / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D054328:Proton Pump Inhibitors; D013995:Time
chemical_list: D000863:Antacids; D004791:Enzyme Inhibitors; D054328:Proton Pump Inhibitors