[The clinical efficacy of the calcium antagonist amlodipine in patients with ischemic heart disease and arterial hypertension].
Overall, eighteen male patients with ischemic heart disease (IHD) and functional class II and III angina concurrent with stage II hypertensive disease were studied for clinical effectiveness of amlodipine (Norvasc), a new calcium antagonist, versus nifedipine and placebo. It has been ascertained that amlodipine (10 mg/day) had a significant antianginal and anti-ischemic effect and antihypertensive activity throughout 24 hours as well whereas nifedipine was effective for 6 to 8 hours. Amlodipine did not affect the well-being of the examined patients.
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D017311:Amlodipine / Q000008:administration & dosage*; D000787:Angina Pectoris / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D009543:Nifedipine / Q000008:administration & dosage; D005082:Physical Exertion; D013997:Time Factors
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D017311:Amlodipine; D009543:Nifedipine