title: [Hemodynamic effects of propofol as an anesthesia induction agent in hyperthyroidism patients on chronic beta-blocker].
abstract: This study was designed to investigate the effect of propofol on the heart rate and blood pressure in the patients on chronic beta-blocker. Seventy two hyperthyroidism patients scheduled for subtotal thyroidectomy were enrolled. Thirty six patients who were on chronic beta-blocker received either propofol (group beta-P) or thiamylal (group beta-T) as an anesthesia induction agent. In control groups, patients who were not on beta-blocker also received either propofol (group C-P) or thiamylal (group C-T). Anesthesia was maintained with nitrous oxide in oxygen and sevoflurane. Heart rate and systolic blood pressures were monitored and recorded before and during anesthesia. Heart rate decreased significantly in group beta-P compared to three other groups through this study. Significant decreases in systolic blood pressure were observed in the groups beta-P and beta-T compared to group C-P. These results suggest that careful attention should be paid to the patients on chronic beta-blocker when propofol was selected as an anesthesia induction agent.
authors.affiliation: Division of Anesthesiology, Noguchi Thyroid Clinic, Beppu.
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Unoshima
authors.forename: N
authors.initials: N
authors.lastname: Takeshima
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Yoshitake
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology* / Q000601:surgery; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D013610:Tachycardia / Q000188:drug therapy; D013965:Thyroidectomy
chemical_list: D000319:Adrenergic beta-Antagonists; D018686:Anesthetics, Intravenous; D015742:Propofol