title: [Chronic septic granulomatosis in a young girl manifesting as invasive pulmonary aspergillosis and flaccid paraplegia].
abstract: The invasive Pulmonary Aspergillosis (IPA) is the principal cause of death in patients with chronic granulomatosis disease (CGD). It can happen before age of one and can reveal the (CGD). Usually, the transmission of GSD is linked to x in 65% of cases. We report, the case of a girl aged 3 years issued from consanguine marriage referred to hospital for hemoptysia. We note that at 40 days she presents an suppurate adenitis. She is hypotrophic at--3DS without respiratory problem, she have a splenomegaly. The radiography chest note an alveolar and interstitial opacity bilateral, apical right and basal left. There is a biological inflammatory syndrome. During the evolution, the child presents a paraplegia secondary to compression myelitis. A D5 laminectomy in urgency was done. The vertebral Biopsia, the serology and the culture isolate fumigatus aspergillus the GCD is evoqued confirmed by the NBT test who was negative.
  
  
  CONCLUSIONS
  --We have to look for GCD in front of pulmonary aspergillus.--The vertebra lesion is secondary to pulmonary lesion.--Our observation is noticeable by the recessive autosomal transmission who was seen in 35% of cases, and by the neurologic complication rarely reported.
authors.affiliation: Service de Médecine Infantile C. Pr Barsaoui, Hôpital d'Enfants.
authors.forename: S
authors.initials: S
authors.lastname: Mazigh M'Rad
authors.forename: K
authors.initials: K
authors.lastname: Sghaier
authors.forename: S
authors.initials: S
authors.lastname: Boukthir
authors.forename: R
authors.initials: R
authors.lastname: Barbouch
authors.forename: S
authors.initials: S
authors.lastname: Barsaoui
mesh_terms: D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D002675:Child, Preschool; D003241:Consanguinity; D017809:Fatal Outcome; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000209:etiology*; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D006469:Hemoptysis / Q000382:microbiology; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D008199:Lymphadenitis / Q000175:diagnosis / Q000209:etiology*; D010264:Paraplegia / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D011379:Prognosis; D013492:Suppuration