title: Leptin injection into white adipose tissue elevates renal sympathetic nerve activity dose-dependently through the afferent nerves pathway in rats.
abstract: Recent studies suggested that leptin in white adipose tissue (WAT) affected the sympathetic out flow to several tissues. We examined whether elevations of renal sympathetic nerve activity (RSNA) and blood pressure (BP) could be observed by leptin injection into WAT in rats. Injections of leptin (10 and 100 ng/ml per kg) into WAT evoked the activation of RSNA dose-dependently. Circulating sympathetic nerve activators, such as leptin, insulin, glucose and lactate, were unchanged by any doses of leptin. In addition, BP was not affected by leptin injections during a 90 min experimental period. These data suggested that leptin activated the afferent nerves through the sensors in WAT, resulting in elevation of RSNA.
authors.affiliation: Laboratory of Exercise and Nutrition, Institute of Health and Sport Sciences, University of Tsukuba, 305-8574, Tsukuba, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tanida
authors.forename: S
authors.initials: S
authors.lastname: Iwashita
authors.forename: Y
authors.initials: Y
authors.lastname: Ootsuka
authors.forename: N
authors.initials: N
authors.lastname: Terui
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000294:innervation* / Q000502:physiology; D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D007328:Insulin / Q000097:blood; D007668:Kidney / Q000187:drug effects* / Q000294:innervation* / Q000378:metabolism / Q000502:physiology; D019344:Lactic Acid / Q000097:blood; D020738:Leptin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D019344:Lactic Acid