Histologic effect of mitomycin C on strabismus surgery in the rabbit.
OBJECTIVE
To evaluate the efficiency of mitomycin C (MMC) in limiting the postoperative inflammatory response and scarring after strabismus surgery.


METHODS
A prospective, two-stage, masked, controlled trial was conducted. In the first stage, the inflammatory response at the extraocular muscle reattachment site was increased after inferior rectus recession in eight rabbits. In the second stage, MMC (0.4 mg/ml) was applied during surgery to the eyes of 22 rabbits with inferior rectus recession. As a control, contralateral eyes were treated with saline solution. Seven weeks later, exenteration was performed, and the sites of muscle reattachment were processed for histologic examinations. The sums of the areas of the granulomas in the extraocular muscle reattachment sites of control and treated eyes were compared.


RESULTS
There was no significant inhibitory effect of MMC on the inflammatory response of treated eyes compared with that of control eyes.


CONCLUSIONS
The intraoperative use of MMC (0.4 mg/ml) was not effective in controlling the postoperative inflammatory response in rabbit eyes after extraocular muscle surgery. These data do not support the hypothesis that MMC reduces postoperative adhesions after strabismus surgery.
Minguini
N
N
Department of Ophthalmology, Faculty of Medical Sciences, and the. Institute of Biology, State University of Campinas, Brazil. minguini@uol.com.br
Monteiro de Carvalho
K M
KM
Akaishi
P M
PM
De Luca
I M
IM
D000818:Animals; D000963:Antimetabolites / Q000627:therapeutic use*; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control; D006099:Granuloma / Q000473:pathology / Q000517:prevention & control*; D007430:Intraoperative Care / Q000379:methods; D016685:Mitomycin / Q000627:therapeutic use*; D009801:Oculomotor Muscles / Q000473:pathology* / Q000601:surgery; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D011817:Rabbits; D013285:Strabismus / Q000601:surgery*
D000963:Antimetabolites; D016685:Mitomycin