title: Replication linkage study for prostate cancer susceptibility genes.
abstract: BACKGROUND
  Since the publication of the first genome screen for prostate cancer (CaP) 5 years ago, over a dozen linkage studies have appeared. Most attention has been directed to chromosome 1, where two separate regions have been identified as harboring a prostate cancer susceptibility locus: HPC1 in the 1q24-25 interval and PCaP in the 1q42.2-43 interval. Linkage analysis of chromosome 16 has also provided evidence of harboring two loci predisposing to CaP.
  
  
  METHODS
  We report on a replication linkage study of chromosomes 1 and 16 in 45 new and 4 expanded multiplex CaP families. Multipoint Z-scores were obtained for 30 highly polymorphic short-sequence tandem repeat markers spanning chromosome 1, and 22 markers spanning chromosome 16.
  
  
  RESULTS
  The replication sample gave no evidence for a CaP susceptibility locus in the 1q24-25 interval and equivocal evidence for such a locus at 1q42.2-43. With respect to chromosome 16, positive Z-scores were obtained over a contiguous interval covering the entire p arm and the proximal half of the q arm.
  
  
  CONCLUSIONS
  The linkage analysis of our replication sample does not support the existence of HPC1, and the evidence for the existence of PCaP remains equivocal. Evidence of a susceptibility locus on 16p remains strong, but the evidence for a susceptibility locus on 16q is weakened.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Suarez
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.forename: J S
authors.initials: JS
authors.lastname: Witte
authors.forename: D V
authors.initials: DV
authors.lastname: Conti
authors.forename: M I
authors.initials: MI
authors.lastname: Resnick
authors.forename: E A
authors.initials: EA
authors.lastname: Klein
authors.forename: J K
authors.initials: JK
authors.lastname: Burmester
authors.forename: D A
authors.initials: DA
authors.lastname: Vaske
authors.forename: T K
authors.initials: TK
authors.lastname: Banerjee
authors.forename: W J
authors.initials: WJ
authors.lastname: Catalona
mesh_terms: D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*