title: Synthesis of a primary metabolite of cannabidiol.
abstract: Cannabidiol 1 is the major nonpsychotropic, neutral constituent in most cannabis preparations. It is devoid of the psychoactive properties typical of cannabis; however, it produces numerous, potentially therapeutic pharmacological effects, some of which may be due to its metabolites. We report now the first total synthesis of 7-hydroxycannabidiol 2, a primary metabolite of cannabidiol, in an eight-step procedure.
authors.affiliation: Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University Medical Faculty, Jerusalem 91120, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Tchilibon
authors.forename: R
authors.initials: R
authors.lastname: Mechoulam
mesh_terms: D002185:Cannabidiol / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D002185:Cannabidiol