title: Age-related changes of MAO-A and -B distribution in human and mouse brain.
abstract: Age-related changes of MAO-A and -B were studied in human and BL/C57 mouse brain areas (substantia nigra, putamen and cerebellum). [3H]Ro41-1049 and [3H]lazabemide were used as selective radioligands to image and quantify MAO-A and MAO-B respectively by enzyme autoradiography. MAO-A binding was higher in mouse, whereas MAO-B binding was higher in human. With aging, mouse MAO-A was significantly reduced between 4 and 8 weeks and remained unchanged until 19 months followed by a slight increase between 19 and 25 months. In contrast, no clear variation was observed in humans between the age of 17-93 years. In most of the structures studied a clear age-related increase in MAO-B was observed beginning in mouse brain at 4 weeks, whereas in human tissue this increase started at the age of 50-60 years. These results show marked differences in the levels and variations of mouse and human MAO-A and -B associated with aging and should be taken into account when extrapolating experimental data from mouse to human.
authors.affiliation: Biochemistry Unit, IDIBAPS, School of Medicine, University of Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Mahy
authors.forename: N
authors.initials: N
authors.lastname: Andrés
authors.forename: C
authors.initials: C
authors.lastname: Andrade
authors.forename: J
authors.initials: J
authors.lastname: Saura
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D008995:Monoamine Oxidase