Effects of hydra peptide morphogen and its analogue and fragments on DNA synthesis in tracheal epithelium and smooth muscle cells in newborn albino rats.
Hydra peptide morphogen, its Arg(7) analogue, and 6C, 3C, and 5N fragments were injected intraperitoneally in a dose 10(-7) mol/kg to newborn rats from the 2nd to 6th day of life. Autoradiography with (3)H-thymidine showed that hydra peptide morphogen and its 6C fragment stimulated DNA synthesis in tracheal epitheliocytes, but inhibited this process in smooth muscle cells. 5N fragment inhibited DNA synthesis in both tissues, while 3C and Arg(7) were ineffective.
Lebed'ko
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OA
Institute of Maternity and Child Welfare, Khabarovsk Branch, Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences.
Timoshin
S S
SS
Rubina
A Y
AY
D000818:Animals; D000831:Animals, Newborn; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D009130:Muscle, Smooth / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009479:Neuropeptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D020545:Respiratory Mucosa / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D014132:Trachea / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism
D008055:Lipids; D009479:Neuropeptides; D010446:Peptide Fragments; C032522:head activator peptide; D004247:DNA; D011761:Pyrrolidonecarboxylic Acid