title: The pharmacokinetics of trinitroglycerin and its metabolites in patients with chronic stable angina.
abstract: OBJECTIVE
  To study the pharmacokinetics of trinitroglycerin (GTN) and its four metabolites in angina patients during their transient use of transdermal GTN tape following intravenous administration of GTN.
  
  
  METHODS
  Four patients received a GTN tape following intravenous administration of 0.1 microg kg-1 min-1 GTN, and the other four patients received two GTN tapes following intravenous administration of 0.2 microg kg-1 min-1 GTN.
  
  
  RESULTS
  Plasma concentrations of GTN in both groups during tape application showed a slight decrease for the hour after the application of the tape and then were con- stant for 24 h. In contrast, the concentrations of dinitroglycerins (GDNs) and mononitroglycerins (GMNs) depended on the duration of previous intravenous administration of GTN. Neither significant cardiovascular changes nor undesirable complications were observed during the study.
  
  
  CONCLUSIONS
  The results suggest that appropriate replacement of intravenous GTN administration with transdermal tape application could maintain a therapeutic GTN level.
authors.affiliation: Department of Intensive Care, Kyoto Prefectural University of Medicine, Kyoto, 602, Japan. satoru@koto.kpu-m.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: E
authors.initials: E
authors.lastname: Yamauchi
authors.forename: A
authors.initials: A
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Shigemi
authors.forename: H
authors.initials: H
authors.lastname: Tsuruta
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics*; D014665:Vasodilator Agents / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D014665:Vasodilator Agents; C014509:dinitroglycerol; D005996:Nitroglycerin