Sulfur regulation of the sulfate transporter genes sutA and sutB in Penicillium chrysogenum.
Penicillium chrysogenum uses sulfate as a source of sulfur for the biosynthesis of penicillin. Sulfate uptake and the mRNA levels of the sulfate transporter-encoding sutB and sutA genes are all reduced by high sulfate concentrations and are elevated by sulfate starvation. In a high-penicillin-yielding strain, sutB is effectively transcribed even in the presence of excess sulfate. This deregulation may facilitate the efficient incorporation of sulfur into cysteine and penicillin.
van de Kamp
M
M
Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9750 AA Haren, The Netherlands.
Schuurs
T A
TA
Vos
A
A
van der Lende
T R
TR
Konings
W N
WN
Driessen
A J
AJ
D027321:Anion Transport Proteins; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D027682:Cation Transport Proteins; D005656:Fungal Proteins; D010408:Penicillium chrysogenum / Q000235:genetics* / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism*
D027321:Anion Transport Proteins; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D005656:Fungal Proteins; D013431:Sulfates; C416129:sutA protein, Penicillium chrysogenum; C416128:sutB protein, Penicillium chrysogenum