title: Cronkhite-Canada syndrome: report of two cases.
abstract: Two cases of Cronkhite-Canada syndrome are reported. In the first case, a 56-year-old woman had an adenoma of the colon, arising within the Cronkhite-Canada polyps, which was removed by endoscopic polypectomy. This suggests possible neoplastic transformation of polyps in this syndrome. She achieved remission with corticosteroids, but the polyposis recurred (only in the stomach) 7 months after the remission. In the recurrent polyposis, corticosteroid therapy resulted again in complete remission, which has lasted for 5 years. In the second case, a 69-year-old man developed typical manifestations of the syndrome while under emotional stress. He had a past history of chronic pityriasis lichenoides, and serum antinuclear antibody was positive. These findings suggested a possible role of autoimmune response in the pathogenesis of the syndrome. Corticosteroids were also effective in this patient.
authors.affiliation: Third Department of Internal Medicine. University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu.
authors.forename: I
authors.initials: I
authors.lastname: Murata
authors.forename: I
authors.initials: I
authors.lastname: Yoshikawa
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: M
authors.initials: M
authors.lastname: Tai
authors.forename: C
authors.initials: C
authors.lastname: Toyoda
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Hirano
authors.forename: M
authors.initials: M
authors.lastname: Otsuki
mesh_terms: D000236:Adenoma / Q000473:pathology; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D003111:Colonic Polyps / Q000473:pathology; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012074:Remission Induction; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones