title: Hemorrhagic problems in obstetrics, exclusive of disseminated intravascular coagulation.
abstract: During pregnancy many physiologic changes occur that result in an increase in coagulation factors and a decrease in fibrinolytic activity. Because hemorrhage during pregnancy is a major cause of maternal morbidity, it is important to recognize and understand the pathophysiology of hereditary and acquired bleeding disorders. This article reviews von Willebrand's disease types 1, 2, and 3 and acquired hemophilia.
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center at Dallas, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Nizzi
authors.forename: G
authors.initials: G
authors.lastname: Mues
mesh_terms: D004211:Disseminated Intravascular Coagulation; D005260:Female; D006467:Hemophilia A / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D014842:von Willebrand Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy