Inositol metabolism in Trypanosoma cruzi: potential target for chemotherapy against Chagas' disease.
Chagas' disease is a debilitating and often fatal disease caused by the protozoan parasite Trypanosoma cruzi. The great majority of surface molecules in trypanosomes are either inositol-containing phospholipids or glycoproteins that are anchored into the plasma membrane by glycosylphosphatidylinositol anchors. The polyalcohol myo-inositol is the precursor for the biosynthesis of these molecules. In this brief review, recent findings on some aspects of the molecular and cellular fate of inositol in T. cruzi life cycle are discussed and identified some points that could be targets for the development of parasite-specific therapeutic agents.
Oliveira
M M
MM
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-590, Brasil. mecia@biof.ufrj.br
Einicker-Lamas
M
M
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy*; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D050356:Lipid Metabolism; D014349:Trypanosoma cruzi / Q000378:metabolism*
D007294:Inositol