Gastrointestinal stromal tumor of the rectum with activating mutation of c-kit: report of a case.
Nonepithelial malignancies of the large bowel are rare. A new disease entity, gastrointestinal stromal tumors, has attracted attention among primary mesenchymal tumors of the gastrointestinal tract. Here we present a case of spindle-cell sarcoma of the rectum, lacking either smooth muscle cells or neural elements. Immunohistochemical findings and sequencing of the c-kit proto-oncogene diagnosed this tumor as a malignant gastrointestinal stromal tumor of the rectum.
Kurokawa
Y
Y
Department of Surgery, Osaka National Hospital, Japan.
Nishisho
I
I
Kawahara
K
K
Mishima
H
H
Hirota
S
S
Kikkawa
N
N
D005260:Female; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D012004:Rectal Neoplasms / Q000235:genetics* / Q000473:pathology; D012509:Sarcoma / Q000235:genetics* / Q000473:pathology
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit