Highly oxidized cuparene-type sesquiterpenes from a mycelial culture of Flammulina velutipes.
Cuparene-type sesquiterpenes were isolated from a culture broth of Flammulina velutipes (Curt.:Fr.) Sing. Using spectroscopic methods (HR-MS, 1H and 13C NMR, and 2D NMR, spectroscopy), their structures were determined to be 2,3,4,5-tetrahydro-2,7-dihydroxy-5,8,10,10-tetramethyl-2,5-methano-1- benzoxepin and 5-methyl-2-(3-oxo-1,2,2-trimethylcyclopentyl)benzoquinone. Both showed antimicrobial activity against Cladosporium herharum and Bacillus subtilis.
Ishikawa
N K
NK
Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
Yamaji
K
K
Tahara
S
S
Fukushi
Y
Y
Takahashi
K
K
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry* / Q000166:cytology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001584:Benzoxepins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
C419012:2,3,4,5-tetrahydro-2,7-dihydroxy-5,8,10,10-tetramethyl-2,5-methano-1- benzoxepin; C419013:5-methyl-2-(3-oxo-1,2,2-trimethylcyclopentyl)benzoquinone; D000890:Anti-Infective Agents; D016227:Benzoquinones; D001584:Benzoxepins; D012717:Sesquiterpenes