title: Simple 1,2-aminoalcohols as strain-specific antimalarial agents.
abstract: We report here the in vitro activity of a selection of 1, 2-aminoalcohol-containing compounds against cloned strains of human Plasmodium falciparum. These compounds exhibit moderate antimalarial activity but a high degree of strain specificity, preferentially inhibiting a chloroquine-resistant strain of the organism.
authors.affiliation: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. howarthj@ccmail.dcu.ie
authors.forename: J
authors.initials: J
authors.lastname: Howarth
authors.forename: D G
authors.initials: DG
authors.lastname: Lloyd
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D004983:Ethanolamines / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007930:Leucine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D000962:Antimalarials; D004983:Ethanolamines; D011480:Protease Inhibitors; D007930:Leucine; C012211:ubenimex