Chemokine concentrations in nasal washings of infants with rhinovirus illnesses.
We determined RANTES (regulated on activation, normal T cell expressed and secreted) and interleukin-8 (IL-8) concentrations, and total white blood cell (WBC) and differential counts in nasal wash samples from rhinovirus-infected infants presenting with wheezing or acute upper respiratory illness alone and compared them with those from healthy infants. RANTES concentrations were significantly greater in acute samples from wheezy patients than in those from patients with acute upper respiratory illness only, or in control samples. IL-8 concentrations and WBC and neutrophil counts were significantly greater in acute samples from wheezy infants and patients with upper respiratory illness alone than in control samples, but they did not differ significantly between the 2 patient groups.
Pacifico
L
L
Institute of Pediatrics, La Sapienza University of Rome-Institute of Experimental Medicine, National Research Council, Rome, Italy. Lucia. Pacifico@Uniroma1.it
Iacobini
M
M
Viola
F
F
Werner
B
B
Mancuso
G
G
Chiesa
C
C
D018946:Chemokine CCL5 / Q000032:analysis; D018925:Chemokines / Q000032:analysis*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000032:analysis; D007958:Leukocyte Count; D017817:Nasal Lavage Fluid / Q000737:chemistry*; D010850:Picornaviridae Infections / Q000150:complications / Q000378:metabolism* / Q000821:virology; D012135:Respiratory Sounds / Q000209:etiology; D012140:Respiratory Tract Diseases / Q000209:etiology; D012229:Rhinovirus
D018946:Chemokine CCL5; D018925:Chemokines; D016209:Interleukin-8