Neurocirculatory consequences of intermittent asphyxia in humans.
We examined the neurocirculatory and ventilatory responses to intermittent asphyxia (arterial O(2) saturation = 79-85%, end-tidal PCO(2) =3-5 Torr above eupnea) in seven healthy humans during wakefulness. The intermittent asphyxia intervention consisted of 20-s asphyxic exposures alternating with 40-s periods of room-air breathing for a total of 20 min. Minute ventilation increased during the intermittent asphyxia period (14.2 +/- 2.0 l/min in the final 5 min of asphyxia vs. 7.5 +/- 0.4 l/min in baseline) but returned to the baseline level within 2 min after completion of the series of asphyxic exposures. Muscle sympathetic nerve activity increased progressively, reaching 175 +/- 12% of baseline in the final 5 min of the intervention. Unlike ventilation, sympathetic activity remained elevated for at least 20 min after removal of the chemical stimuli (150 +/- 10% of baseline in the last 5 min of the recovery period). Intermittent asphyxia caused a small, but statistically significant, increase in heart rate (64 +/- 4 beats/min in the final 5 min of asphyxia vs. 61 +/- 4 beats/min in baseline); however, this increase was not sustained after the return to room-air breathing. These data demonstrate that relatively short-term exposure to intermittent asphyxia causes sympathetic activation that persists after removal of the chemical stimuli. This carryover effect provides a potential mechanism whereby intermittent asphyxia during sleep could lead to chronic sympathetic activation in patients with sleep apnea syndrome.
Xie
A
A
Department of Medicine, University of Wisconsin, Madison 53705, USA. axie@facstaff.edu
Skatrud
J B
JB
Crabtree
D C
DC
Puleo
D S
DS
Goodman
B M
BM
Morgan
B J
BJ
D000328:Adult; D001237:Asphyxia / Q000503:physiopathology*; D001794:Blood Pressure; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000098:blood supply / Q000294:innervation / Q000503:physiopathology*; D010543:Peroneal Nerve / Q000503:physiopathology*; D015656:Respiratory Mechanics; D012867:Skin / Q000294:innervation; D013990:Tidal Volume; D013997:Time Factors