Inflammatory response and angiogenesis after percutaneous transmyocardial laser revascularization.
BACKGROUND
The aim of our study was to investigate the inflammatory response immediately after percutaneous transmyocardial laser revascularization (PTMR) along with the underlying mechanism of angiogenesis.


METHODS
Patients with angina pectoris underwent coronary angiography and were divided into two groups. Group A (n = 10) included patients with obstructed vessels who received PTMR, whereas group B (n = 5) comprised patients who had normal coronary arteries. Blood levels of neutrophils, procalcitonin, troponin-I, myoglobin, and creatine kinase (CK) mass were evaluated in each patient before angiography and monitored up to 48 hours after the procedure. Six patients were injected with 99mTc-leukoscan approximately 60 to 90 minutes after PTMR. During the 240 to 300 minutes after the radionuclide administration, single photon emission tomography (SPET) was performed and compared with conventional 99mTc-sestamibi-SPET.


RESULTS
A significant increase in blood levels of neutrophils and procalcitonin was observed in group A only (p < 0.005). A slight but significant increase of troponin-I was evident in the same group (p < 0.05), and a distinct myocardial uptake of 99mTc-Leukoscan-SPET was observed in each patient along homologous regions treated by PTMR.


CONCLUSIONS
The increased amount of neutrophils (both circulating and inside the treated myocardial areas) along with the raised levels of procalcitonin were the immediate reactions to PTMR. This systemic and intramyocardial inflammatory response is the underlying mechanism that gives rise to angiogenesis.
Bortone
A S
AS
Department of Emergency and Transplantation, and Institute of Nuclear Medicine, University of Bari School of Medicine, Italy. emobort@libero.it
D'Agostino
D
D
Schena
S
S
Rubini
G
G
Brindicci
P
P
Sardaro
V
V
D'Addabbo
A
A
de Luca Tupputi Schinosa
L
L
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D053685:Laser Therapy; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009204:Myocardial Revascularization; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009504:Neutrophils; D011498:Protein Precursors / Q000097:blood; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon; D019210:Troponin I / Q000097:blood
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; C000606589:CALCA protein, human; D011498:Protein Precursors; D019210:Troponin I; C101172:Sulesomab; D013667:Technetium; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide