Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene.
The human tyrosinase-related protein 2 (TRP-2) gene promoter contains a cis-regulatory element (positions -447 to -416), termed DOPAchrome tautomerase distal enhancer 1 (DDE1). DDE1 functions as an enhancer in cultured melanoma cells and its core element includes a potential binding site for transcription factors containing a high-mobility-group domain. This core element is bound in vitro by multiple nuclear proteins, which are preferentially expressed in melanoma cells. DDE1 represents a composite enhancer that may be involved in melanocyte-specific transcription of the human TRP-2 gene.
Amae
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Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Aoba-ku, Sendai, 980-8575, Miyagi, Japan.
Yasumoto
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Takeda
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Udono
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Takahashi
K
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Shibahara
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D001483:Base Sequence; D004742:Enhancer Elements, Genetic / Q000235:genetics* / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics / Q000502:physiology; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000378:metabolism; D014407:Tumor Cells, Cultured
D014157:Transcription Factors; D019746:Intramolecular Oxidoreductases; C042501:dopachrome isomerase