Treatment of recalcitrant ulcers in pyoderma gangrenosum with mycophenolate mofetil and autologous keratinocyte transplantation on a hyaluronic acid matrix.
Pyoderma gangrenosum sometimes takes a recalcitrant course that is unresponsive to standard immuno-suppression with corticosteroids and/or cyclosporin A. In these cases improvement of painful ulcerations is a therapeutic challenge. We report a 17-year-old boy with severe pyoderma gangrenosum treated successfully with mycophenolate mofetil and autologous keratinocyte transplantation using an esterified hyluronic acid delivery system.
Wollina
U
U
Department of Dermatology and Allergology Friedrich-Schiller-University of Jena, Germany. uwol@derma.uni-jena.de
Karamfilov
T
T
D000293:Adolescent; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015603:Keratinocytes / Q000637:transplantation*; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000628:therapy*; D014182:Transplantation, Autologous
D007166:Immunosuppressive Agents; D006820:Hyaluronic Acid; D009173:Mycophenolic Acid