title: Organ malperfusion in acute aortic dissection.
abstract: OBJECTIVE
  Organ malperfusion in aortic dissection can precipitate a serious condition. The strategy of treatment for it has been controversial. We have focused on the strategy and outcome of acute aortic dissection with organ malperfusion.
  
  
  METHODS
  Between January 1995 and December 1998, 134 acute aortic dissection patients were admitted. There were 73 males (65.4 +/- 8.0 years old) and 61 females (66.7 +/- 7.4 years old). There were 83 patients of Stanford type A, and 51 patients of type B. Of them, 24 patients (17.9%) were complicated by organ malperfusion. The brain was affected in 4, the heart in 5, the spinal cord in 2, the liver in 1, the intestine in 1, the kidney in 4, and the lower extremities in 10 patients. Our management strategy for a patient with malperfusion in acute aortic dissection was that the antecedent operation was initially mandatory, and central grafting was secondarily considered.
  
  
  RESULTS
  Refusal of operation or lethal conditions excluded 8 of the 24 patients from operation. An antecedent operation was mandatory in eight of the remaining 16 patients. The overall mortality was 33.3% (8/24 patients), and operative mortality was 31.3% (5/16 patients) in the patients with malperfusion. The overall mortality was 11.8% (13/110 patients), and the operative mortality was 11.1% (9/81 patients) in the patients without malperfusion.
  
  
  CONCLUSIONS
  Organ malperfusion is a major component in the management and treatment of acute aortic dissection. Only an appropriate strategy and therapy could result in a satisfactory outcome.
authors.affiliation: Second Department of Surgery, Faculty of Medicine, Kagoshima University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Toda
authors.forename: Y
authors.initials: Y
authors.lastname: Moriyama
authors.forename: H
authors.initials: H
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Iguro
authors.forename: A
authors.initials: A
authors.lastname: Yamaoka
authors.forename: A
authors.initials: A
authors.lastname: Taira
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000150:complications*; D001014:Aortic Aneurysm / Q000150:complications*; D002318:Cardiovascular Diseases / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D007422:Intestines / Q000098:blood supply; D007668:Kidney / Q000098:blood supply; D007866:Leg / Q000098:blood supply; D008099:Liver / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D013116:Spinal Cord / Q000098:blood supply; D014652:Vascular Diseases / Q000209:etiology*