[Drugs for veno-lymphatic insufficiency].
Treatment of venous and lymphatic insufficiency of the lower limbs is based on 3 components: elastic support, venotonic drugs and radical treatments (surgery or sclerotherapy) of insufficient veins. Venotonic drugs have specific indications limited to functional impairment: heavy feeling in the legs, pain and impatience in the evening. There are different categories of venolymphatic drugs. Flavonoids have various pharmacological actions, most notably an increase in venous tone, reduction of capillary permeability and increase of capillary resistance. Choice of a venotonic drug is funded on knowledge of pharmacodynamics and pharmacokinetics of the molecule, critical evaluation of clinical studies, physician's personal experience and drug cost. Venotonic drugs are useful when venous insufficiency leads to functional manifestations. They are especially the treatment of heavy leg syndromes during warm seasons when elastic support is uncomfortable.
Priollet
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Service de médecine vasculaire et de médecine interne Hôpital Saint-Joseph, Paris. pascal.priollet@wanadoo.fr
Boisseau
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MR
D000244:Adenosine Diphosphate / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D002199:Capillary Permeability / Q000187:drug effects; D002200:Capillary Resistance / Q000187:drug effects; D016527:Drug Costs; D005419:Flavonoids / Q000627:therapeutic use; D020441:Ginkgo biloba / Q000627:therapeutic use; D006801:Humans; D018579:Patient Selection; D008517:Phytotherapy; D010946:Plants, Medicinal; D014665:Vasodilator Agents / Q000145:classification / Q000191:economics / Q000494:pharmacology / Q000627:therapeutic use*; D014689:Venous Insufficiency / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D005419:Flavonoids; D014665:Vasodilator Agents; D000244:Adenosine Diphosphate; D001205:Ascorbic Acid