title: Wegener's granulomatosis in the upper respiratory tract.
abstract: Wegener's granulomatosis is a distinct clinico-pathological entity characterised by necrotising vasculitis of small arteries and veins in conjunction with the formation of granuloma in the upper and lower respiratory tracts, and glomerulonephritis. The vast majority of patients have antineutrophil cytoplasmic antibodies in the serum with a characteristic cytoplasmic pattern. However, in early phases of the disease only the upper respiratory tract may be affected, clinical and histological features may be nonspecific, and antineutrophil cytoplasmic antibodies not present. In this paper we present four patients with involvement of the upper respiratory tract suspicious for early Wegener's granulomatosis. We emphasise the significance of clinical, histological and serological parameters in the early detection of Wegener's granulomatosis.
authors.affiliation: Institute of Pathology, Faculty of Medicine, Ljubljana, Slovenia. nina.zidar@mf.uni-lj.si
authors.forename: N
authors.initials: N
authors.lastname: Zidar
authors.forename: M
authors.initials: M
authors.lastname: Volavsek
authors.forename: C
authors.initials: C
authors.lastname: Trcek
authors.forename: I
authors.initials: I
authors.lastname: Kern
authors.forename: N
authors.initials: N
authors.lastname: Gale
mesh_terms: D000368:Aged; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology / Q000473:pathology*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000473:pathology*; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis; D008297:Male; D012140:Respiratory Tract Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic