title: Effect of transpulmonary pressure on airway diameter and responsiveness of immature and mature rabbits.
abstract: We previously demonstrated that airway responsiveness is greater in immature than in mature rabbits; however, it is not known whether there are maturational differences in the effect of transpulmonary pressure (Ptp) on airway size and airway responsiveness. The relationship between Ptp and airway diameter was assessed in excised lungs insufflated with tantalum powder. Diameters of comparable intraparenchymal airway segments were measured from radiographs obtained at Ptp between 0 and 20 cmH(2)O. At Ptp > 8 cmH(2)O, the diameters were near maximal in both groups. With diameter normalized to its maximal value, changing Ptp between 8 and 0 cmH(2)O resulted in a greater decline of airway caliber in immature than mature airways. The increases in lung resistance (RL) in vivo at Ptp of 8, 5, and 2 cmH(2)O were measured during challenge with intravenous methacholine (MCh: 0.001-0.5 mg/kg). At Ptp of 8 cmH(2)O, both groups had very small responses to MCh and the maximal fold increases in RL did not differ (1.93 +/- 0.29 vs. 2.23 +/- 0.19). At Ptp of 5 and 2 cmH(2)O, the fold increases in RL were greater for immature than mature animals (13.19 +/- 1.81 vs. 3.89 +/- 0.37) and (17.74 +/- 2.15 vs. 4.6 +/- 0.52), respectively. We conclude that immature rabbits have greater airway distensibility and this difference may contribute to greater airway narrowing in immature compared with mature rabbits.
authors.affiliation: Departments of Pediatrics, and Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors.forename: X
authors.initials: X
authors.lastname: Shen
authors.forename: R
authors.initials: R
authors.lastname: Ramchandani
authors.forename: B
authors.initials: B
authors.lastname: Dunn
authors.forename: R
authors.initials: R
authors.lastname: Lambert
authors.forename: S J
authors.initials: SJ
authors.lastname: Gunst
authors.forename: R S
authors.initials: RS
authors.lastname: Tepper
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D008168:Lung / Q000254:growth & development / Q000502:physiology*; D011312:Pressure; D011817:Rabbits; D014132:Trachea / Q000254:growth & development / Q000502:physiology*