Effects of low-density lipoproteins on blood coagulation and fibrinolytic activity.
In vitro experiments showed that copper-oxidized low-density lipoproteins activate factors of the prothrombin complex in the whole blood and inhibit fibrin generation in both blood and plasma. Moreover, oxidized low-density lipoproteins inhibit fibrinolysis and impair the structure of fibrin clot, which results in hypercoagulation.
Azizova
O A
OA
Laboratory of Biophysical Basis of Pathology, Institute of Physicochemical Medicine, Russian Ministry of Health.
Roitman
E V
EV
Dement'eva
I I
II
Nikitina
N A
NA
Gagaeva
E V
EV
Lopukhin
Y M
YM
D001777:Blood Coagulation / Q000187:drug effects*; D003300:Copper / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011517:Prothrombin Time; D013916:Thrombelastography; D013918:Thrombin Time
D008077:Lipoproteins, LDL; D003300:Copper