title: [Primary large cell neuroendocrine carcinoma of the kidney: morphologic and immunohistochemical features of two cases].
abstract: Primary neuroendocrine carcinomas of the kidney are infrequent. The large cell neuroendocrine carcinoma is a subtype with an aggressive course and a worse prognosis. We report two cases, a 35-year-old man and a 75-year-old woman who died within 6 and 5-months after surgery despite radical nephrectomy and chemotherapy. Histological and immunohistochemical features are presented.
authors.affiliation: Services d'Anatomie et de Cytologie Pathologiques, Hôpital Calmette, CHRU 59037 Lille Cedex. d-moukassa@chru-lille.fr
authors.forename: D
authors.initials: D
authors.lastname: Moukassa
authors.forename: X
authors.initials: X
authors.lastname: Leroy
authors.forename: B
authors.initials: B
authors.lastname: Bouchind'homme
authors.forename: F
authors.initials: F
authors.lastname: Saint
authors.forename: L
authors.initials: L
authors.lastname: Lemaître
authors.forename: B
authors.initials: B
authors.lastname: Gosselin
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008297:Male; D009392:Nephrectomy; D013311:Streptozocin / Q000008:administration & dosage
chemical_list: D013311:Streptozocin; D004317:Doxorubicin