Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide.
Described here are the synthesis of five-membered iminocyclitols with galacto-configuration and a pseudodisaccharide, and their inhibitory activities against beta-galactosyltransferase, beta-galactosidase and alpha-mannosidase.
Saotome
C
C
Frontier Research Program, The Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
Kanie
Y
Y
Kanie
O
O
Wong
C H
CH
D000438:Alcohols / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D001236:Aspergillus oryzae; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D002417:Cattle; D004187:Disaccharides / Q000138:chemical synthesis / Q000494:pharmacology; D019075:Electrophoresis, Capillary; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D007887:Fabaceae; D005700:Galactosyltransferases / Q000037:antagonists & inhibitors; D006863:Hydrogen-Ion Concentration; D007097:Imines / Q000138:chemical synthesis / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008361:Mannosidases / Q000037:antagonists & inhibitors; D018716:Molecular Mimicry; D009005:Monosaccharides / Q000138:chemical synthesis / Q000494:pharmacology; D010946:Plants, Medicinal; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D043323:alpha-Mannosidase; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors
D000438:Alcohols; D002241:Carbohydrates; D004187:Disaccharides; D004791:Enzyme Inhibitors; D007097:Imines; D009005:Monosaccharides; D011759:Pyrrolidines; D005700:Galactosyltransferases; D008361:Mannosidases; D001616:beta-Galactosidase; D043323:alpha-Mannosidase