Effect of stimulus size on static visual fields in patients with retinitis pigmentosa.
OBJECTIVE
To determine the effect of stimulus size on sensitivity of patients with retinitis pigmentosa (RP) as measured by automated static perimetry.


METHODS
Comparative case series.


METHODS
Thirty-nine patients with RP and a control group of 10 healthy volunteers.


METHODS
Automated static perimetry (full threshold programs 24-2 or 30-2) was performed twice on one eye of each participant using stimulus sizes III (0.43 degrees diameter) and V (1.72 degrees diameter). Data from the same 50 test locations were used from each field.


METHODS
At each location, for each participant, the size effect was computed as the difference (in decibels) in sensitivities for sizes V and III, and the average sensitivity was computed as the mean of sensitivities for the two sizes.


RESULTS
For both patient and control groups, the size effect was negatively correlated with average sensitivity (r(2) > 0.124; P: < 0.001). The mean size effect was significantly greater for the patient group than for the control group: 8.6 (+/- 3.6) dB versus 5. 4 (+/- 2.2) dB (t = 18.0; P: < 0.001). The percentage of abnormal locations (more than 8 dB below mean normal) tended to be lower for size V than for size III, with a mean of 67% for size V versus 95% for size III. The percentage of absolute defects was also lower for size V than for size III, with a mean of 35% for size V versus 54% for size III.


CONCLUSIONS
In damaged regions of the visual fields of patients with RP, increase in stimulus size from III to V can produce abnormally large increases in perimetric sensitivity. Size III may be more useful than size V for detection of field abnormality, whereas size V may be more useful than size III for observing progression of advanced RP.
Swanson
W H
WH
Retina Foundation of the Southwest, Dallas, Texas, USA.
Felius
J
J
Birch
D G
DG
D006801:Humans; D012160:Retina / Q000503:physiopathology*; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*