title: Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis.
abstract: A concise, stereospecific synthesis of radicicol dimethyl ether is presented. The strategy relies on a convergent three-stage assembly of the 14-membered lactone which has, as a key transformation, a novel ring-forming metathesis reaction utilizing a vinyl epoxide.
authors.affiliation: The Laboratory for Bioorganic Chemistry, The Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Garbaccio
authors.forename: S J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007783:Lactones / Q000737:chemistry*; D018942:Macrolides
chemical_list: D000903:Antibiotics, Antineoplastic; D007202:Indicators and Reagents; D007783:Lactones; D018942:Macrolides; C035359:monorden