Cytokine-secreting tumor cell vaccines.
Modification of the tumor microenvironment with gene transfer techniques stimulates two immune mechanisms that effectuate tumor destruction. One involves improved tumor-antigen presentation for the development of specific cellular and humoral immunity. The second involves compromise of the tumor vasculature by soluble factors and leukocytes.
Mach
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Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Dranoff
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G
D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D018664:Interleukin-12 / Q000378:metabolism*
D019496:Cancer Vaccines; D018664:Interleukin-12; D016178:Granulocyte-Macrophage Colony-Stimulating Factor