Knowledge about transplantation tolerance gained in primates.
Research in transplantation tolerance relies on application of successful strategies in a nonhuman-primate organ transplant model for preclinical testing. Three principal approaches are being evaluated: hematopoietic chimerism, lymphocyte depletion and costimulation blockade. Interactive work in these three areas has yielded much new information on mechanisms of tolerance and opened the door to pilot clinical trials. Clinical application of xenotransplantation is likely to depend on such strategies.
Knechtle
S J
SJ
Department of Surgery, University of Wisconsin Hospital, Madison 53792-7375, USA. stuart@tx.surgery.wisc.edu
D000818:Animals; D023201:CD40 Ligand / Q000276:immunology; D006801:Humans; D008212:Lymphocyte Depletion; D011323:Primates; D023001:Transplantation Tolerance; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D023201:CD40 Ligand