Cyclooxygenase mechanisms.
Several advances have occurred in the past year in our understanding of cyclooxygenase catalysis. The role of specific heme oxidation states in the formation of catalytically competent tyrosyl radicals has been defined; the identity of physiological hydroperoxide activators has been established; and the participation of individual amino acids in substrate binding and oxygenation has been elucidated.
Marnett
L J
LJ
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. marnett@toxicology.mc.vanderbilt.edu
D016718:Arachidonic Acid / Q000378:metabolism; D001665:Binding Sites; D006418:Heme / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D013379:Substrate Specificity
D016877:Oxidants; D016718:Arachidonic Acid; D006418:Heme; D011451:Prostaglandin-Endoperoxide Synthases