title: Pathophysiology of grass tetany and other hypomagnesemias. Implications for clinical management.
abstract: Magnesium is an essential mineral with many physiologic and biochemical functions. Surprisingly, Mg homeostasis is not regulated by a hormonal feedback system, but simply depends on inflow (absorption) from the gastrointestinal tract and outflow (endogenous secretion, requirement for milk production, uptake by tissues). Any surplus (inflow greater than outflow) is excreted via urine. Conversely, if the outflow (mainly milk secretion and endogenous loss) exceeds inflow, hypomagnesemia occurs because of the lack of hormonal mechanisms of homeostasis. The major reason for insufficient inflow is a reduced absorption of Mg from the forestomachs. Recent studies from our laboratory and data from the literature permit the proposal of a putative transport model for the secondary active transport of Mg across the rumen epithelium. This model includes two uptake mechanisms across the luminal membrane (PD-dependent and PD-independent) and basolateral extrusion via a Na/Mg exchange. The well-known negative interaction between ruminal K concentration and Mg absorption can be explained on the basis of this model: an increase of ruminal K depolarizes the potential difference of the luminal membrane, PDa, and as the driving force for PD-dependent (or K-sensitive) Mg uptake. Because Na deficiency causes an increase of K concentration in saliva and ruminal fluid, Na deficiency should be considered a potentially important risk factor. The data obtained from in vitro and in vivo studies on the association of Mg transport, changes of ruminal K concentration, and PDa are extensive and confirm the model, if the ruminal Mg concentrations are below 2 to 3 mM. It is further proposed by the model that the PD-independent Mg uptake mechanism is primarily working at high ruminal Mg concentration (above 2 mM). Mg absorption becomes more and more independent of ruminal K with increasing Mg concentration, which can be considered as an explanation for the well-known prophylaxis of hypomagnesemia by increasing oral Mg intake. Fermentation products, NH4+ and SCFA, influence Mg absorption. The possible meaning regarding the pathogenesis of hypomagnesemia is not quite clear. A sudden increase of ruminal NH4+ should be avoided, because high NH4+ concentrations transiently reduce Mg absorption. The most prominent signs of hypomagnesemia are excitations and muscle cramps, which are closely correlated with the Mg concentration in the CSF. It is suggested that the clinical signs are caused by spontaneous activation of neurons in the CNS at low Mg concentrations, which leads to tetany. Prophylactic measures are discussed in context with the known effects on ruminal Mg absorption.
authors.affiliation: Department of Veterinary Physiology, Faculty of Veterinary Medicine, Free University of Berlin, Germany. martens@vetmed.fu-berlin.de
authors.forename: H
authors.initials: H
authors.lastname: Martens
authors.forename: M
authors.initials: M
authors.lastname: Schweigel
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D015511:Goat Diseases / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D006041:Goats; D008274:Magnesium / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary*; D006109:Poaceae / Q000506:poisoning; D012417:Rumen / Q000378:metabolism; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D013746:Tetany / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D008274:Magnesium