Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides.
The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.
Nefzi
A
A
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA.
Giulianotti
M A
MA
Ong
N A
NA
Houghten
R A
RA
D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*
D007093:Imidazoles; D009842:Oligopeptides