[High-throughput techniques for analyzing SNPs and application of SNPs to pharmacogenomics].
Progress in the human genome project can contribute to molecular diagnosis of various diseases and development of novel treatments. The next logical step for human genetics is the exploration and elucidation of genes involved in differential pharmacological response. An understanding of the role that genes have in pharmacological response is the cornerstone of personalized medicine. The pharmacogenomics approach is necessary and useful for this purpose. This article introduces these concepts to provide a context for the use of SNPs in pharmacogenomics and high-throughput techniques to analyze them.
Tanoue
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Division of Pediatric Pharmacology, National Children's Medical Research Center, Tokyo, Japan.
D006801:Humans; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide