title: Effects of somatosensory input on central fatigue: a pilot study.
abstract: OBJECTIVE
  Depression of motor evoked potentials (MEPs) following transcranial magnetic stimulation (TMS) may be a sign of central motor fatigue. As a pilot study, we have examined whether post-exercise MEP depression can be compensated by application of sensory stimuli prior to TMS.
  
  
  METHODS
  We studied 15 healthy volunteers (aged 21-28 years) who were required to perform an exercise protocol of ankle dorsiflexion until force fell below 66% of maximum force. MEPs were recorded from the right tibialis anterior muscle. Prior to TMS, electrical stimuli were applied to the ipsilateral sural nerve with an individual interstimulus interval between 50 and 80 ms.
  
  
  RESULTS
  MEP areas decreased after exercise. When a sensory stimulus was administered MEPs did not change.
  
  
  CONCLUSIONS
  We conclude that the effects of central fatigue may be influenced by application of sensory stimuli.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, 30623, Hannover, Germany. rollnik.jens@mh-hannover.de
authors.forename: J D
authors.initials: JD
authors.lastname: Rollnik
authors.forename: M
authors.initials: M
authors.lastname: Schubert
authors.forename: J
authors.initials: J
authors.lastname: Albrecht
authors.forename: K
authors.initials: K
authors.lastname: Wohlfarth
authors.forename: R
authors.initials: R
authors.lastname: Dengler
mesh_terms: D000328:Adult; D004558:Electric Stimulation; D019054:Evoked Potentials, Motor / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005221:Fatigue / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects