title: Are L5 fractures an indicator of metastasis?
abstract: OBJECTIVE
  To determine whether L5 vertebral body fractures are an indicator of malignancy.
  
  
  METHODS
  A retrospective study of L5 vertebral body fractures was carried out using plain radiographs, CT, and/or MRI. Over a 5-year period, 51 patients with L5 vertebral body fractures were seen at our institution. Since L1 vertebral body fractures are common, 51 age- and gender-matched (20 men, 31 women; mean age 60 years) patients with L fractures were utilized as the control group. The frequency of neoplastic infiltration of the vertebrae was compared between these two populations to determine whether pathologic fracture was more frequent at L5.
  
  
  RESULTS
  Twelve (24%) of the L5 fractures were pathologic compared with four (8%) of the L1 fractures (chi-square test, P<0.05). Neoplasm types included multiple myeloma (n=4), prostate (n=3), breast (n=2), lung (n=2), melanoma (n=2), bladder, colon, and leukemia (each n=1).
  
  
  CONCLUSIONS
  Although most L5 fractures are not pathologic, there is an increased incidence of pathologic fractures in this location compared with L1. Therefore, a fracture of L5 should raise the suspicion of metastasis.
authors.affiliation: Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Lo
authors.forename: M E
authors.initials: ME
authors.lastname: Schweitzer
authors.forename: V
authors.initials: V
authors.lastname: Juneja
authors.forename: N
authors.initials: N
authors.lastname: Shabshin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000293:injuries*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications; D012189:Retrospective Studies; D016103:Spinal Fractures / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D013125:Spinal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000556:secondary*; D014057:Tomography, X-Ray Computed