An expeditious route to eight- and nine-membered carbocycles based on a RCM-ring fragmentation strategy
The presence of a temporary one-atom internal tether in 1,9-deca- and 1,10-undecadienes allows their efficient ring-closing metathesis (RCM). Cleavage of the bridging tether of the resulting bicycles provides eight- or nine-membered carbocycles, medium-sized rings that are difficult to assemble using other currently available procedures.
Rodriguez
JR
Departamento de Quimica Organica y Unidad Asociada al CSIC, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Spain.
Castedo
L
Mascarenas
JL