Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterisation of immunodominant T- and B-cell epitopes.
Eight rhesus monkeys with different MHC backgrounds were immunized with myelin oligodendrocyte glycoprotein (MOG). All developed severe experimental autoimmune encephalomyelitis associated with large inflammatory foci and extensive demyelination. T-cell autoreactivity to MOG was directed against three main epitopes encompassed within amino acids 4-20, 35-50 and 94-116, of which two are also immunodominant epitopes for the autoimmune T cell response to MOG in patients with MS. A strong B cell response to MOG was observed in all monkeys and major epitopes recognized were located within amino acids 4-26, 24-46 and 44-66/54-76.
Kerlero de Rosbo
N
N
Department of Immunology, The Weizmann Institute of Science, 76100, Rehovot, Israel. lcbennun@wicc.weizmann.ac.il
Brok
H P
HP
Bauer
J
J
Kaye
J F
JF
't Hart
B A
BA
Ben-Nun
A
A
D000818:Animals; D001323:Autoantibodies / Q000097:blood; D019070:Cell Lineage / Q000276:immunology; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D018985:Epitopes, B-Lymphocyte / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D005260:Female; D007114:Immunization; D016056:Immunodominant Epitopes / Q000276:immunology; D008253:Macaca mulatta; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology* / Q000494:pharmacology; D063308:Myelin-Oligodendrocyte Glycoprotein
D001323:Autoantibodies; D018985:Epitopes, B-Lymphocyte; D018984:Epitopes, T-Lymphocyte; D016056:Immunodominant Epitopes; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein