[Characteristics of lipid peroxidation in various tissues during acute stress and its correction by pyracetam and cerebrolysin].
The process of lipid peroxidation (LPO), the activity of antioxidant enzymes, and the effects of piracetam (300 mg/kg) and cerebrolysin (0.1 ml/kg) were studied in the brain, liver, thymus, spleen, and blood serum of white male rats under acute stress (immobilization) conditions. The results of analyses confirmed that the stress syndrome development involves the LPO acceleration and retardation stages not coinciding in various tissues. The antioxidant effect of the nootropic agents in CNS has a permanent character, being independent of the initial status of the animal organism. The effect of both drugs upon the LPO level in peripheral tissues has a modulative character and can be considered as a sum of the central antistressor action and the direct influence upon the functional activity of effectors.
Deviatkina
T A
TA
State Medical Stomatological Academy, Poltava, Ukraine.
Vazhnichaia
E M
EM
Lytsenko
R V
RV
D000208:Acute Disease; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D009928:Organ Specificity; D010889:Piracetam / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000201:enzymology / Q000378:metabolism; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances; D013950:Thymus Gland / Q000201:enzymology / Q000378:metabolism
D000596:Amino Acids; D000975:Antioxidants; D018697:Nootropic Agents; D017392:Thiobarbituric Acid Reactive Substances; C006952:cerebrolysin; D002374:Catalase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D010889:Piracetam