Catalase activity in human erythrocytes: effect of phenoxyherbicides and their metabolites.
The effects of exposure to different concentrations of phenoxyherbicides and their metabolites were studied in human erythrocytes, with particular attention to catalase (CAT-EC. 1.11.1. 6- hydrogen peroxide: hydrogen peroxide oxidoreductase). 4-chloro-2-methylphenoxyacetic acid (MCPA), 2,4-dimethylphenol (2, 4-DMP) and 2,4-dichlorophenoxyacetic acid (2,4-D) did not affect CAT activity, but 2,4-dichlorophenol (2,4-DCP) and 2,4,5-trichlorophenol (2,4,5-TCP) decrease its activity, the latter being the more inhibitory.
Bukowska
B
B
Department of Biophysics and Environmental Pollution, University of Lódz, Banacha 12/16, Lódz, 90-237, Poland. bukow@biol.uni.lodz.pl
Chajdys
A
A
Duda
W
W
Duchnowicz
P
P
D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology; D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D002374:Catalase / Q000187:drug effects* / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D006540:Herbicides / Q000494:pharmacology*; D006801:Humans; D014992:Xylenes / Q000494:pharmacology
D000890:Anti-Infective Agents; D006540:Herbicides; D014992:Xylenes; D015084:2,4-Dichlorophenoxyacetic Acid; C027804:2,4-dimethylphenol; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D002374:Catalase