Mechanisms of chronic rejection.
Chronic rejection remains the major obstacle to long-term allograft survival. Detailed understanding of putative etiologic risk factors, both antigen-dependent and -independent, is important for designing effective therapeutic strategies to ameliorate this process. Cell senescence may be an important factor in chronic rejection.
Waaga
A M
AM
Surgical Research Laboratory, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
Gasser
M
M
Laskowski
I
I
Tilney
N L
NL
D000818:Animals; D016922:Cellular Senescence; D006084:Graft Rejection / Q000209:etiology*; D006650:Histocompatibility Testing; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D012307:Risk Factors
D007519:Isoantigens