title: [Morphologic course of prostatic hyperplasia].
abstract: OBJECTIVE
  To find a morphologic model of the development of prostate hyperplasia.
  
  
  METHODS
  Study of the transitional zone in 60 patients (30 with infravesical obstruction, 30 with no obstructive symptoms) and quantification of the involved surface, number of pure stromal and glandular-stromal nodes, node area for each of them, and non-nodular area of the transitional zone, correlating each parameter to age based on clinical status.
  
  
  RESULTS
  The greater transitional zone area is seen in patients with obstruction: 1376.83 +/- 408.17 mm2 vs 321.39 +/- 151.49 mm2 in asymptomatic patients, mainly due to a higher number of glandular-stromal nodes (17 vs 2.2) and their size, with a correlation to age (p = 0.03). Moderate increases of non-nodular areas are also found.
  
  
  CONCLUSIONS
  These findings suggest that onset of prostate hyperplasia may be due to a consistent increase of the transitional area, and that in some patients, probably because of local factors, nodular development occurs as a result of both an increase in nodes number and size.
authors.affiliation: Sección de Patología Fundació Puigvert, Barcelona.
authors.forename: F
authors.initials: F
authors.lastname: Algaba Arrea
authors.forename: I
authors.initials: I
authors.lastname: Trias
authors.forename: L
authors.initials: L
authors.lastname: López
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez-Vallejo
authors.forename: J
authors.initials: J
authors.lastname: González Esteban
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000473:pathology*