A space-time adaptive method for simulating complex cardiac dynamics.
For plane-wave and many-spiral states of the experimentally based Luo-Rudy 1 model of heart tissue in large (8 cm square) domains, we show that a space-time-adaptive time-integration algorithm can achieve a factor of 5 reduction in computational effort and memory-but without a reduction in accuracy-when compared to an algorithm using a uniform space-time mesh at the finest resolution. Our results indicate that such an algorithm can be extended straightforwardly to simulate quantitatively three-dimensional electrical dynamics over the whole human heart.
Cherry
E M
EM
Department of Computer Science, Duke University, P.O. Box 90129, Durham, North Carolina 27708-0129, USA. emc@cs.duke.edu
Greenside
H S
HS
Henriquez
C S
CS
D000465:Algorithms; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D055592:Biophysical Phenomena; D001703:Biophysics; D003198:Computer Simulation; D004594:Electrophysiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular