Marginal keratitis: an uncommon form of topical dorzolamide allergy.
OBJECTIVE
To report a case of marginal keratitis resulting from topical dorzolamide hypersensitivity.


METHODS
Case report.


RESULTS
A 68-year-old woman presented with bilateral marginal keratitis 2 weeks after commencing bilateral topical dorzolamide. One week after discontinuation of topical dorzolamide, the patient was asymptomatic with complete resolution of corneal infiltrates.


CONCLUSIONS
Topical dorzolamide may cause a hypersensitivity reaction in the form of marginal keratitis. Discontinuation of the offending medication should result in complete resolution.
Taguri
A H
AH
Ophthalmology, Princess Alexandra Eye Pavilion, University of Edinburgh, Scotland, United Kingdom.
Khan
M A
MA
Sanders
R
R
D000287:Administration, Topical; D000368:Aged; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007634:Keratitis / Q000139:chemically induced* / Q000473:pathology; D009883:Ophthalmic Solutions / Q000009:adverse effects / Q000627:therapeutic use; D013449:Sulfonamides / Q000009:adverse effects* / Q000627:therapeutic use; D013876:Thiophenes / Q000009:adverse effects* / Q000627:therapeutic use
D002257:Carbonic Anhydrase Inhibitors; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide