Tissue factor pathway of coagulation in sepsis.
OBJECTIVE
To review the role of the tissue factor pathway of coagulation in experimental sepsis.


METHODS
Studies published in biomedical journals.


METHODS
Studies on the role of the tissue factor pathway in animal or human models for sepsis.


METHODS
Variables reflecting tissue factor pathway activation in the various models are discussed; the effects of administration of tissue factor pathway inhibitors on these and inflammatory variables, as well as on the course and outcome, are analyzed.


CONCLUSIONS
Activation of coagulation during experimental sepsis occurs mainly, if not exclusively, via the tissue factor pathway; inhibitors of this pathway improve mortality, presumably by a combined attenuating effect on coagulative and inflammatory responses.
Hack
C E
CE
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Department of Clinical Chemistry, Academic Hospital Vrije Universiteit, Amsterdam. hack@clb.nl
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D006801:Humans; D018805:Sepsis / Q000503:physiopathology*; D013925:Thromboplastin / Q000502:physiology*
D013925:Thromboplastin