title: Central venous catheter-related infections in children on long-term home parenteral nutrition: incidence and risk factors.
abstract: OBJECTIVE
  This study aimed to assess the incidence and etiology of central venous catheter (CVC) infections in children on home parenteral nutrition (HPN).
  
  
  METHODS
  207 CVC-years were studied retrospectively in 47 children on HPN, aged 8.1+/-5.0 years.
  
  
  RESULTS
  125 CVC were used (means: 2.6 CVC/patient and 21 months utilization/CVC). Half of the hospitalizations (162) were due to proven CVC-related infections. The mean infection incidence was 2. 1/1000 HPN days. The total population divided in two groups below and above this value: group one including 24 children, incidence < or = 2.1 per 1000 days (mean: 0.83) and group two including 23 children, incidence >2.1 per 1000 days (mean: 4.3). No differences were found between the two groups in terms of underlying disease, presence of ostomies, age at the time of HPN onset, or micro-organisms responsible. The only differences (p<0.05) were the mean duration of HPN (longer in group one) and the delay between HPN onset and the first infection (longer in group one).
  
  
  CONCLUSIONS
  This study does not highlight any risk factors for CVC infection. However, early CVC infections after HPN onset appear to predict a bad prognosis.
authors.affiliation: Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Colomb
authors.forename: M
authors.initials: M
authors.lastname: Fabeiro
authors.forename: M
authors.initials: M
authors.lastname: Dabbas
authors.forename: O
authors.initials: O
authors.lastname: Goulet
authors.forename: J
authors.initials: J
authors.lastname: Merckx
authors.forename: C
authors.initials: C
authors.lastname: Ricour
mesh_terms: D000293:Adolescent; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007239:Infections / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D008297:Male; D016331:Parenteral Nutrition, Home; D012189:Retrospective Studies; D012307:Risk Factors