title: Pyrazolo-triazoles as light activable DNA cleaving agents.
abstract: In view of the continuous interest in new DNA cleaving compounds, both for the development of new therapeutic agents and for the possible use as reagents in nucleic acids research, a few pyrazolo[3,4-d][1,2,3]triazole derivatives have been obtained and investigated for their antiproliferative activity and capability to cleave DNA, after light-activation. A possible in situ activation, i.e. in neoplastic tissues, of less cytotoxic derivatives, may lead to potential antitumor compounds endowed with high therapeutic indexes.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy. mv9@dns.unife.it
authors.forename: S
authors.initials: S
authors.lastname: Manfredini
authors.forename: C B
authors.initials: CB
authors.lastname: Vicentini
authors.forename: M
authors.initials: M
authors.lastname: Manfrini
authors.forename: N
authors.initials: N
authors.lastname: Bianchi
authors.forename: C
authors.initials: C
authors.lastname: Rutigliano
authors.forename: C
authors.initials: C
authors.lastname: Mischiati
authors.forename: R
authors.initials: R
authors.lastname: Gambari
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000528:radiation effects; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016259:Genes, myc / Q000235:genetics; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D008027:Light; D010782:Photolysis; D011401:Promoter Regions, Genetic / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology* / Q000528:radiation effects; D011960:Receptors, Estrogen / Q000235:genetics; D014230:Triazoles / Q000494:pharmacology* / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents; D011720:Pyrazoles; D011960:Receptors, Estrogen; D014230:Triazoles; D004247:DNA