title: Rupture of multiple parallel molecular bonds under dynamic loading.
abstract: Biological adhesion often involves several pairs of specific receptor-ligand molecules. Using rate equations, we study theoretically the rupture of such multiple parallel bonds under dynamic loading assisted by thermal activation. For a simple generic type of cooperativity, both the rupture time and force exhibit several different scaling regimes. The dependence of the rupture force on the number of bonds is predicted to be either linear, like a square root, or logarithmic.
authors.affiliation: Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Am Mühlenberg 2, 14476 Golm, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Seifert
mesh_terms: D001665:Binding Sites; D008024:Ligands; D008954:Models, Biological; D008956:Models, Chemical; D010825:Physics / Q000379:methods
chemical_list: D008024:Ligands