Pramipexole is a possible effective treatment for primary orthostatic tremor (shaky leg syndrome).
OBJECTIVE
To report the successful treatment of primary orthostatic tremor in a 76-year-old man.


BACKGROUND
Primary orthostatic tremor is a rare condition, with few reports describing therapies. Established therapies had previously failed in our patient.


METHODS
Using an evidence-based evaluation of treatments via MEDLINE's GRATEFUL MED search engine, a therapeutic option was determined during the first consultation with the patient, and pramipexole therapy was initiated.


RESULTS
The therapy proved effective, and the patient had relief from his symptoms for the first time in 6 years.


CONCLUSIONS
Pramipexole is a potential therapy for primary orthostatic tremor. Arch Neurol. 2000;57:1519-1520
Finkel
M F
MF
Department of Neurology, Cleveland Clinic Naples, 6101 Pine Ridge Rd, Naples, FL 34119, USA. finkelm@ccf.org.
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D052160:Benzothiazoles; D019317:Evidence-Based Medicine; D006801:Humans; D007024:Hypotension, Orthostatic / Q000150:complications* / Q000175:diagnosis; D007866:Leg / Q000503:physiopathology*; D008297:Male; D000077487:Pramipexole; D012720:Severity of Illness Index; D013844:Thiazoles / Q000627:therapeutic use*; D016896:Treatment Outcome; D014202:Tremor / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology
D000978:Antiparkinson Agents; D052160:Benzothiazoles; D013844:Thiazoles; D000077487:Pramipexole