Sialyl-Tn- and neuron-specific enolase-positive minimally differentiated erythroleukemia.
Flow cytometric, immunochemical and molecular studies were performed on leukemic blasts from a patient with minimally differentiated erythroleukemia (AML-M6v). The blasts expressed CD36 and CD71 but not lymphoid antigens, myeloid antigens, CD41 or glycophorin A. Analysis of carbohydrate antigens showed that the blasts expressed the sialyl-Tn antigen. Immunochemistry revealed that the blasts had neuron-specific enolase (NSE). Serum sialyl-Tn and NSE levels were markedly increased. Finally, an erythroid lineage was confirmed in the presence of alpha-globin messages in the blasts. Sialyl-Tn and NSE expression in leukemic blasts may be useful to identify AML-M6v.
Muroi
K
K
Department of Hematology, Center for Molecular Medicine, Jichi Medical School, Tochigi.
Tarumoto
T
T
Akioka
T
T
Kirito
K
K
Nagai
T
T
Izumi
T
T
Nakamura
M
M
Hatake
K
K
Hakomori
S
S
Miura
Y
Y
Ozawa
K
K
D015703:Antigens, CD / Q000378:metabolism; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015152:Blotting, Northern; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D005434:Flow Cytometry; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*
D015703:Antigens, CD; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C055491:sialosyl-Tn antigen; D010751:Phosphopyruvate Hydratase