Study on polymorphism of MICA exon 5 microsatellite in Shanghai Han population.
OBJECTIVE
To investigate the polymorphism distribution of MICA gene exon 5 microsatellite in Shanghai Han population and study the relationship of MICA gene and its closely linked gene HLA B.


METHODS
The microsatellite polymorphism of MICA exon 5 in 175 unrelated healthy individuals were investigated using PCR-heteroduplex analysis.


RESULTS
(1)There are 5 alleles of the microsatellite polymorphism in exon 5 of the MICA gene in Shanghai Han population, the gene frequency of MICA*A5 is the highest(39.14%), the next is MICA*A5.1(22.29%). (2)There is strong linkage disequilibrium between the HLA-B and MICA STR loci, e.g. MICA*A5 and HLA-B15, MICA*A4 and HLA-B27.


CONCLUSIONS
The polymorphism distribution of MICA gene and the linkage disequilibrium between MICA and HLA-B have deviations in different ethnic groups.
Guo
Z
Z
Shanghai Second Medical University, Shanghai Institute of Immunology, Shanghai, 200025 P.R.China.
Xu
L
L
Fan
L
L
Ge
Y
Y
Yao
F
F
Yang
J
J
D002681:China / Q000208:ethnology; D005091:Exons; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A