title: Gallbladder localization of (19)F MRS catabolite signals in patients receiving bolus and protracted venous infusional 5-fluorouracil.
abstract: The hepatobiliary distribution of 5-fluorouracil (5FU) catabolites was investigated in nine patients. Using fluorine 3D-chemical shift imaging, four patients receiving protracted venous infusion of 5FU demonstrated catabolite localized to the gallbladder. No hepatobiliary fluorine signals were detected in three patients whose gallbladders were absent or abnormal. Signals from the gallbladder showed a 2.2-2.4 ppm high-frequency shift from alpha-fluoro-beta-alanine, suggesting the presence of alpha-fluoro-beta-alanine-bile-acid conjugates. 3D-chemical shift imaging of two patients receiving bolus 5FU revealed alpha-fluoro-beta-alanine to be localized to the liver within 1 hr of administration. In one patient examined 4 hr after bolus administration, catabolite signal was detected only in the gallbladder.
authors.affiliation: CRC Clinical Magnetic Resonance Research Group, Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Dzik-Jurasz
authors.forename: D J
authors.initials: DJ
authors.lastname: Collins
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: I J
authors.initials: IJ
authors.lastname: Rowland
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005704:Gallbladder / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015091:beta-Alanine / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D000964:Antimetabolites, Antineoplastic; D015091:beta-Alanine; C032348:alpha-fluoro-beta-alanine; D005472:Fluorouracil