Urinary cortisol to cortisone metabolites in hypertensive obese children.
Childhood obesity is accompanied by a variety of cardiovascular risk factors (hypertension, insulin resistance, dyslipidaemia) which tend to aggregate (syndrome X). 11beta-hydroxysteroid dehydrogenase (11beta-HSD) is supposed to play a role in the pathogenesis of hypertension and the development of syndrome X. There are two isoforms of 11beta-HSD. 11beta-HSD-2 is responsible for the inactivation of cortisol to inactive cortisone. In the case of impaired enzyme activity the ratio of urinary tetrahydrocortisol (THF)+ its isomer allotetrahydrocortisol (5alpha-THF)/tetrahydrocortisone (THE) is elevated. 11beta-HSD-1 is an oxo-reductase, which type catalyses the conversion of cortisone to cortisol. The aim of the present study was to investigate if there was any alteration in the urinary cortisol metabolites reflecting 11beta-HSD activity in hypertensive obese children (no.=15) as compared to normotensive obese (no.=11) and normotensive non-obese children (no.=15). We found an increased excretion of cortisol metabolites in hypertensive obese children compared to obese and normal - weight children having normal blood pressure. The ratio of THF+5alpha(THF/THE had a significant correlation with systolic blood pressure. On the basis of our study the ratio of THF+5alpha-THF/ THE reflecting on altered enzyme activity seems to be an independent factor influencing especially systolic blood pressure in hypertensive obese children.
Csábi
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GY
Department of Pediatrics,University Medical School of Pecs, Hungary.
Juricskay
S
S
Molnár
D
D
D042842:11-beta-Hydroxysteroid Dehydrogenases; D000273:Adipose Tissue; D000293:Adolescent; D001823:Body Composition; D001824:Body Constitution; D015992:Body Mass Index; D003348:Cortisone / Q000652:urine*; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism; D006973:Hypertension / Q000150:complications* / Q000652:urine*; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000150:complications* / Q000652:urine*; D013760:Tetrahydrocortisol / Q000652:urine; D013761:Tetrahydrocortisone / Q000652:urine
D007527:Isoenzymes; D013761:Tetrahydrocortisone; D013760:Tetrahydrocortisol; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D003348:Cortisone; D006854:Hydrocortisone