title: The impact of chronic hepatitis B viral infection on gastrointestinal motility.
abstract: OBJECTIVE
  Disturbed gastrointestinal (GI) motility probably exists in alcoholic cirrhotic patients; however, the influence of chronic hepatitis B virus (HBV) infection on GI motility remains unknown. The purpose of this prospective study was to determine the impact of chronic HBV infection on human GI transit, and to explore the possible patient factors modulating GI motility.
  
  
  METHODS
  We used a non-invasive hydrogen breath test measuring the oro-caecal transit time (OCTT) to assess the GI motility in 45 asymptomatic HBV carriers, 26 patients with chronic hepatitis B, 23 patients with HBV-related liver cirrhosis, and 45 age- and sex-matched healthy volunteers. Their clinical symptoms and various blood parameters, such as platelet count, prothrombin time, etc. were recorded. Plasma substance P, nitrate/nitrite and endothelin-1 levels were also measured.
  
  
  RESULTS
  The OCTTs in controls, HBV carriers, chronic hepatitis B and liver cirrhosis patients were (mean +/- SEM) 78.4 +/- 5.8, 80.9 +/- 4.2, 93.9 +/- 8.8 and 106.5 +/- 12.4 min, respectively. The OCTT was delayed in patients with HBV-related liver cirrhosis compared to that of controls (P=0.039). Among the cirrhotic patients, presentation with ascites delayed OCTT (145.7 +/- 27.2 versus 91.3 +/- 11.9 min, P=0.039). Neither Child- Pugh grade, portal hypertension, various blood parameters, plasma substance P, nitrate/nitrite or endothelin-1 levels had any influence on OCTT.
  
  
  CONCLUSIONS
  HBV infection alone does not alter GI motility, whereas the patients with liver cirrhosis may have delayed GI motility. Ascites is most likely a factor responsible for the delayed GI transit among chronic HBV-infected subjects.
authors.affiliation: Department of Medicine, Veterans General Hospital-Taipei, and National Yang-Ming University School of Medicine, Taiwan.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: C L
authors.initials: CL
authors.lastname: Lu
authors.forename: F Y
authors.initials: FY
authors.lastname: Chang
authors.forename: Y S
authors.initials: YS
authors.lastname: Huang
authors.forename: F Y
authors.initials: FY
authors.lastname: Lee
authors.forename: R H
authors.initials: RH
authors.lastname: Lu
authors.forename: K
authors.initials: K
authors.lastname: Lih-Jiun
authors.forename: S D
authors.initials: SD
authors.lastname: Lee
mesh_terms: D000368:Aged; D001944:Breath Tests; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D005772:Gastrointestinal Transit; D019694:Hepatitis B, Chronic / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012737:Sex Factors; D013997:Time Factors
chemical_list: D019332:Endothelin-1