Cadaver donor screening for infectious agents in solid organ transplantation.
The transmission of infection by a cadaver donor organ can result not only in loss of the allograft but also in death of the immunosuppressed recipient. Despite the shortage of cadaver organ donors, every donor must be evaluated thoroughly for the potential transmission of infectious disease, because the consequences of the organ donor events can have a profound effect on the transplant outcome. This review summarizes current knowledge about serological screening of organ donors to determine the suitability of organs from cadaver donors for transplantation.
Delmonico
F L
FL
New England Organ Bank and Harvard Medical School, Newton, MA, USA. francis_delmonico @neob.com
D002102:Cadaver; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000209:etiology; D006509:Hepatitis B / Q000175:diagnosis / Q000209:etiology; D006526:Hepatitis C / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D016377:Organ Transplantation / Q000009:adverse effects; D014015:Tissue Banks / Q000592:standards*; D014019:Tissue Donors; D014777:Virus Diseases / Q000175:diagnosis* / Q000209:etiology