Acute interstitial nephritis and fatal Stevens-Johnson syndrome after propylthiouracil therapy.
We report a case of acute interstitial nephritis and fatal Stevens-Johnson syndrome in a 90-year-old woman with amiodarone-induced hyperthyroidism, who had been treated for 5 weeks with propylthiouracil (PTU). On admission, the patient exhibited acute renal failure and generalized macular purpuric eruption. Acute interstitial nephritis and Stevens-Johnson syndrome were diagnosed and PTU withdrawn. Although renal function recovered after PTU withdrawal and corticosteroid therapy, the patient's condition worsened, and she died after developing multiple organ failure. Acute interstitial nephritis seems to be rarely associated with PTU therapy. Moreover, a literature review suggested that this could represent the first published report of a Stevens-Johnson syndrome developing during PTU therapy.
Dysseleer
A
A
Department of Endocrinology, Université Catholique de Louvain, Cliniques Universitaires St. Luc, Brussels, Belgium.
Buysschaert
M
M
Fonck
C
C
Van Ginder Deuren
K
K
Jadoul
M
M
Tennstedt
D
D
Cosyns
J P
JP
Daumerie
C
C
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D011441:Propylthiouracil / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
D013956:Antithyroid Agents; D011441:Propylthiouracil