[Levels of interleukin-4, interleukin-5, tryptase and eosinophil cationic protein of nasal lavage fluid in pollen allergic rhinitis].
IL-4, IL-5, tryptase and eosinophil cationic protein levels were measured in nasal lavage fluid from 15 pollen allergic rhinitis beyond pollen season. Allergy was proved by prick test. There were 15 non allergic children in the control group. Specific nasal allergen provocation was performed on the rhinitic group. Nasal lavage were done before, 1 and 12 hours after the provocation. Before the nasal provocation the ECP and IL-4 levels were significantly higher in the allergic group compared to the non allergic group. The levels of tryptase, ECP and IL-4 rose significantly after the provocation. The results reflect to the possibility of an activated immune status in allergic rhinitis even without the presence of the triggering pollens. After the specific provocation elevated tryptase levels were measured, referring to the activity of the early phase of the I. type hypersensitivity reaction, while the ECP and IL-5 elevation to its late phase. According to our examinations it can be said, that tryptase, ECP and IL-5 might be used to detect the activation of the early and late phases of the IgE mediated hypersensitive reaction.
Rapp
J
J
Gyermek Allergológiai Központ és Központi Laboratórium, Svábhegyi Gyermekgyógyintézet, Budapest.
Kósa
L
L
Halász
A
A
Kereki
E
E
Börzsönyi
L
L
D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D001798:Blood Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D053818:Chymases; D047091:Eosinophil Granule Proteins; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D015848:Interleukin-5 / Q000378:metabolism*; D008297:Male; D008934:Mitogens / Q000378:metabolism*; D009666:Nose; D006255:Rhinitis, Allergic, Seasonal / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D012260:Ribonucleases; D012697:Serine Endopeptidases / Q000378:metabolism*; D007507:Therapeutic Irrigation; D053802:Tryptases
D015415:Biomarkers; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D015848:Interleukin-5; D008934:Mitogens; D015847:Interleukin-4; D007073:Immunoglobulin E; D012260:Ribonucleases; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases