[Immunoguided surgery].
Radioimmunoguided surgery has been attempted using intraoperative tumor detection with radiolabeled monoclonal antibody (mAb). Directly radiolabeled mAb showed poor tumor imaging due to high blood-pool radioactivity. In 1991, three-step immunoscintigraphy of the avidin-biotin system was reported. This three-step method improved tumor imaging because it reduced background radioactivity. Although there were some problems such as a human anti-mouse response and anti-avidin response, the three-step clinical protocol was performed in various cancer patients, and many good results (the tumor detection rate was about 85%) were reported. On the other hand, recent major trials on tumor localization and sentinel lymph node detection have been performed using FDG-PET. However, radioimmunoscintigraphy has the major advantage of simultaneous tumor diagnosis and treatment. In the near future, radioimmunoscintigraphy may become a useful diagnostic method with anticancer effects when its adverse effects are ameliorated by the application of gene technology.
Yamana
H
H
Multidisciplinary Treatment Center, Kurume University School of Medicine, Japan.
D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000601:surgery; D004938:Esophageal Neoplasms / Q000276:immunology / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000601:surgery*; D016719:Radioimmunodetection / Q000379:methods*; D011868:Radioisotopes
D000911:Antibodies, Monoclonal; D011868:Radioisotopes