[The effect of chronic exposure to cadmium and gamma radiation at low doses on the genetic structures in mice].
The DNA-protein cross-links (DPC) in mouse thymocytes and spleen lymphocytes, the number of abnormal sperm heads (ASH) and the number of micronuclei (MN) in normochromatic erythrocytes (NCE) of peripheral blood were studied in mice exposed to long-term low-intensity gamma radiation (0.072 cGy/days) and/or cadmium with drinking water (0.01 mg Cd2+/l) for 20, 40 and 80 days. The dependence of DPC level on the total dose (exposure time) of gamma radiation and/or cadmium is nonlinear. The maximal level of DPC in cells of lymphoid organs upon exposure to gamma radiation or cadmium was recorded on the 40-th day, and under combined exposure on the 20-th day of the experiment. The long-term exposure to cadmium or gamma radiation causes an increase in the ASH frequency. The increase in frequencies of MN in NCE and reciprocal translocations in spermatocytes was not found.
Osipov
A N
AN
Moscow State Enterprise--United Ecology-Technology and Science-Industry Center for Decontamination of Radioactive Waste and Environmental Protection (Research and Industrial Association Radon), Russia. aosipov@radon.ru
Grigor'ev
M V
MV
Sypin
V D
VD
Pomerantseva
M D
MD
Ramaĭia
L K
LK
Shevchenko
V A
VA
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D003432:Cross-Linking Reagents / Q000633:toxicity*; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays / Q000009:adverse effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects / Q000528:radiation effects; D013077:Sperm Head / Q000187:drug effects / Q000528:radiation effects; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013950:Thymus Gland / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D014178:Translocation, Genetic / Q000187:drug effects / Q000528:radiation effects
D003432:Cross-Linking Reagents; D002104:Cadmium; D004247:DNA