title: A vertebrate globin expressed in the brain.
abstract: Haemoglobins and myoglobins constitute related protein families that function in oxygen transport and storage in humans and other vertebrates. Here we report the identification of a third globin type in man and mouse. This protein is predominantly expressed in the brain, and therefore we have called it neuroglobin. Mouse neuroglobin is a monomer with a high oxygen affinity (half saturation pressure, P50 approximately 2 torr). Analogous to myoglobin, neuroglobin may increase the availability of oxygen to brain tissue. The human neuroglobin gene (NGB), located on chromosome 14q24, has a unique exon-intron structure. Neuroglobin represents a distinct protein family that diverged early in metazoan evolution, probably before the Protostomia/Deuterostomia split.
authors.affiliation: Institute of Zoology, Johannes Gutenberg University Mainz, Germany. burmeste@mail.uni-mainz.de
authors.forename: T
authors.initials: T
authors.lastname: Burmester
authors.forename: B
authors.initials: B
authors.lastname: Weich
authors.forename: S
authors.initials: S
authors.lastname: Reinhardt
authors.forename: T
authors.initials: T
authors.lastname: Hankeln
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D003001:Cloning, Molecular; D005091:Exons; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D005914:Globins / Q000096:biosynthesis* / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007438:Introns; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000302:isolation & purification; D000078787:Neuroglobin; D010100:Oxygen / Q000378:metabolism; D011993:Recombinant Fusion Proteins; D017386:Sequence Homology, Amino Acid
chemical_list: D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D011993:Recombinant Fusion Proteins; D005914:Globins; D010100:Oxygen