title: Proliferation of maxillary and mandibular periodontal squamous cells in mink fed 3,3',4,4',5-pentachlorobiphenyl (PCB 126).
abstract: This report characterizes squamous cell proliferation in young farm mink (Mustela vison) fed a diet supplemented with 0.024 ppm 3,3',4,4',5-pentachlorobiphenyl (polychlorinated biphenyl [PCB] congener 126). One to 2 months of dietary exposure to PCB 126 resulted in gross lesions of the upper and lower jaws consisting of mandibular and maxillary nodular proliferation of the gingiva and loose teeth. The maxilla and mandible of the PCB-treated mink were markedly porous because of loss of alveolar bone. Histologically, this osteoporosis was caused by proliferation of squamous cells that formed infiltrating cords. This report clearly documents the fact that the environmental contaminant PCB 126 can cause osteoinvasive squamous proliferation in young mink, although the dose used in the present study was 7 and 36 times higher than what is typically encountered in contaminated bird eggs and fish, respectively.
authors.affiliation: Department of Veterinary Pathology, Michigan State University, East Lansing 48824, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Render
authors.forename: R J
authors.initials: RJ
authors.lastname: Aulerich
authors.forename: S J
authors.initials: SJ
authors.lastname: Bursian
authors.forename: R F
authors.initials: RF
authors.lastname: Nachreiner
mesh_terms: D000284:Administration, Oral; D016301:Alveolar Bone Loss / Q000139:chemically induced* / Q000662:veterinary*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004032:Diet; D004785:Environmental Pollutants / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D008297:Male; D008336:Mandibular Diseases / Q000139:chemically induced* / Q000662:veterinary*; D008907:Mink; D011078:Polychlorinated Biphenyls / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl