Antimicrobial proteins and peptides of blood: templates for novel antimicrobial agents.
The innate immune system provides rapid and effective host defense against microbial invasion in a manner that is independent of prior exposure to a given pathogen. It has long been appreciated that the blood contains important elements that mediate rapid responses to infection. Thus, anatomic compartments with ample blood supply are less frequently infected and recover more readily once infected, whereas regions with poor perfusion are prone to severe infection and may require surgical debridement. Blood-borne innate immune mediators are either carried in circulating blood cells (ie, leukocytes and platelets) or in plasma after release from blood cells or on secretion by the liver. (Blood. 2000;96:2664-2672)
Levy
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Division of Infectious Disease, The Children's Hospital, Boston, MA 02115, USA. levy_o@a1.tch.harvard.edu
D000287:Administration, Topical; D000336:Aerosols; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000627:therapeutic use; D023181:Antimicrobial Cationic Peptides; D001001:Anura / Q000502:physiology; D001424:Bacterial Infections / Q000188:drug therapy; D001770:Blood Bactericidal Activity; D001773:Blood Cells / Q000502:physiology; D001798:Blood Proteins / Q000008:administration & dosage / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D015195:Drug Design; D006801:Humans; D007239:Infections / Q000097:blood*; D016131:Lymphocyte Subsets / Q000502:physiology; D008565:Membrane Proteins; D051379:Mice; D009504:Neutrophils / Q000502:physiology; D010455:Peptides / Q000097:blood / Q000737:chemistry / Q000502:physiology / Q000627:therapeutic use; D010587:Phagocytosis; D010802:Phylogeny; D018521:Plant Physiological Phenomena; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
D000336:Aerosols; D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D008565:Membrane Proteins; D010455:Peptides; D011994:Recombinant Proteins; C021623:bactericidal permeability increasing protein