title: Environmental exposure to dioxin: the Seveso experience.
abstract: The toxicity in humans of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a man-made compound and environmental pollutant, is still debated. The industrial accident at Seveso, Italy, in 1976 exposed a large population of both sexes and of all ages to a massive concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Monitoring of soil and measurement of blood samples allowed classification of the exposed population into three categories: A, B and R (high, medium and low exposure, respectively). This article presents data from longitudinal health monitoring of the population, including liver function, immune function, neurological impairment, dermatological effects, reproductive pathology, and mortality.
authors.affiliation: Department of Laboratory Medicine, University of Milano-Bicocca, Hospital of Desio, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Signorini
authors.forename: P M
authors.initials: PM
authors.lastname: Gerthoux
authors.forename: C
authors.initials: C
authors.lastname: Dassi
authors.forename: M
authors.initials: M
authors.lastname: Cazzaniga
authors.forename: P
authors.initials: P
authors.lastname: Brambilla
authors.forename: N
authors.initials: N
authors.lastname: Vincoli
authors.forename: P
authors.initials: P
authors.lastname: Mocarelli
mesh_terms: D000062:Accidents, Occupational; D000328:Adult; D002648:Child; D004702:Endocrine Glands / Q000187:drug effects; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007558:Italy; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008137:Longitudinal Studies; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009420:Nervous System / Q000187:drug effects / Q000503:physiopathology; D000072317:Polychlorinated Dibenzodioxins / Q000097:blood / Q000633:toxicity*; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D012867:Skin / Q000187:drug effects / Q000473:pathology
chemical_list: D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins