title: New bioactive aromatic compounds from Vismia guianensis.
abstract: Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl3 extract of the roots of Vismia guianensis by bioassay-directed fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic.
authors.affiliation: Chemistry and Life Sciences Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA.
authors.forename: E K
authors.initials: EK
authors.lastname: Seo
authors.forename: M C
authors.initials: MC
authors.lastname: Wani
authors.forename: M E
authors.initials: ME
authors.lastname: Wall
authors.forename: H
authors.initials: H
authors.lastname: Navarro
authors.forename: R
authors.initials: R
authors.lastname: Mukherjee
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D004247:DNA / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001577:Benzophenones; D004247:DNA