Ticlopidine, Alka-Seltzer, or a combination of citric acid with aspirin: effects on platelet aggregation in individuals with an insufficient response to aspirin alone.
Aspirin (ASA) does not effectively lower platelet aggregation in all people. The platelet aggregation (PA) score is an easily used clinical method for measuring the effect in individuals of antiplatelet medications. Fifteen apparently healthy subjects (2 men and 13 women), selected for their resistance to ASA's antiaggregation effect, completed a sequential trial of ticlopidine, Alka-Seltzer, and ASA + citric acid (CTA). Ticlopidine was the strongest aggregation inhibitor and the ASA + CTA combination was more inhibitory than Alka-Seltzer. It was determined that measuring antiaggregation effects of a particular agent in an individual prior to usage would optimize treatment. The PA score methodology provides a means for testing patients prior to antiplatelet therapy for prevention and treatment of the thrombotic complications of vascular disease.
Kaplan
S
S
The Hope Heart Institute, Seattle, Washington 98122, USA. kaplana@prodigy.net
Kaplan
A
A
Marcoe
K
K
Sauvage
L R
LR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology; D002951:Citrates / Q000008:administration & dosage / Q000494:pharmacology; D019343:Citric Acid / Q000008:administration & dosage / Q000494:pharmacology; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology*; D017693:Sodium Bicarbonate / Q000008:administration & dosage / Q000494:pharmacology; D013988:Ticlopidine / Q000008:administration & dosage / Q000494:pharmacology
D002951:Citrates; D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; D019343:Citric Acid; C002931:sodium acetylsalicylate, sodium bicarbonate, sodium citrate drug combination; D017693:Sodium Bicarbonate; D013988:Ticlopidine; D001241:Aspirin