Immunomodulatory and anti-inflammatory activity of Picrorhiza scrophulariiflora.
Extracts of the rhizomes of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae) were investigated for their in vitro and in vivo immunomodulatory properties. Diethyl ether extracts showed potent inhibitory activity towards the classical pathway of the complement system, the respiratory burst of activated polymorphonuclear leukocytes, and mitogen-induced proliferation of T-lymphocytes. Furthermore, such extracts showed anti-inflammatory activity towards carrageenan-induced paw edema. No effects were observed in experimentally induced arthritis in mice.
Smit
H F
HF
Section of Medicinal Chemistry, Department of Pharmacy, Universiteit Utrecht, PO Box 80082, 3508 TB, Utrecht, The Netherlands. h.f.smit@pharm.uu.ul
Kroes
B H
BH
van den Berg
A J
AJ
van der Wal
D
D
van den Worm
E
E
Beukelman
C J
CJ
van Dijk
H
H
Labadie
R P
RP
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy; D001769:Blood / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003171:Complement Pathway, Classical / Q000187:drug effects*; D004487:Edema / Q000188:drug therapy*; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts