title: Effects of weight variability on cardiovascular risk factors; a study of nonsmoking Japanese male office workers.
abstract: OBJECTIVE
  To determine the effects of weight variability on cardiovascular risk factors.
  
  
  METHODS
  Longitudinal study (followed from 1990 to 1998).
  
  
  METHODS
  Five-hundred and eighty nonsmoking Japanese male office workers aged 25-49 y.
  
  
  METHODS
  Baseline levels and slopes of seven selected cardiovascular risk factors (systolic and diastolic blood pressure, total and high-density lipoprotein cholesterol, triglyceride, uric acid and hemoglobin A1c) and body mass index (BMI) variables (baseline BMI, BMI-slope, the root mean square error (BMI-RMSE), and the BMI-slope x BMI-RMSE interaction).
  
  
  RESULTS
  From the multiple regression analyses, the slopes of the six cardiovascular risk factors, except hemoglobin A1c, were most strongly related to the baseline level of each cardiovascular risk factor and BMI-slope. Neither BMI-RMSE nor the interaction of BMI-RMSE with BMI-slope was related to these cardiovascular risk factor slopes. As for hemoglobin A1c, BMI-slope and the interaction of BMI-RMSE with BMI-slope were not significantly related to hemoglobin A1c slope but baseline BMI and BMI-RMSE were. Furthermore, hemoglobin A1c slope values were significantly higher among those who cycled at >4.0 kg than among those who did not.
  
  
  CONCLUSIONS
  The only cardiovascular risk factor associated with BMI variability was hemoglobin A1c. Weight variability had less or little impact on cardiovascular risk factors compared with BMI-slope and baseline BMI.
authors.affiliation: Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine F2, Suita-shi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Nakanishi
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Tatara
mesh_terms: D000328:Adult; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D006442:Glycated Hemoglobin; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology* / Q000209:etiology; D009790:Occupations; D012044:Regression Analysis; D012307:Risk Factors; D012907:Smoking
chemical_list: D006442:Glycated Hemoglobin