title: Leukemic relapse as T-acute lymphoblastic leukemia in a patient with acute myeloid leukemia and a minor T-cell clone at diagnosis.
abstract: OBJECTIVE
  Lineage classification needs to be established before starting chemotherapy in acute leukemias. In some cases, mixed populations can be found and these are differentiated by antigenic expression patterns.
  
  
  METHODS
  We report the case of a patient with acute myelogenous leukemia whose relapse was classified as T-acute lymphoblastic leukemia (T-ALL).
  
  
  RESULTS
  Flow cytometry analysis at diagnosis enabled us to identify a minor T-cell subclone which progressively increased and became dominant at relapse. There were no changes at cytogenetic and molecular levels.
  
  
  CONCLUSIONS
  This case illustrates the usefulness of multiparametric flow cytometry for assessing minor leukemic populations.
authors.affiliation: Department of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Bellido
authors.forename: R
authors.initials: R
authors.lastname: Martino
authors.forename: A
authors.initials: A
authors.lastname: Aventín
authors.forename: M J
authors.initials: MJ
authors.lastname: Carnicer
authors.forename: E
authors.initials: E
authors.lastname: Rubiol
authors.forename: O
authors.initials: O
authors.lastname: López
authors.forename: J
authors.initials: J
authors.lastname: Sierra
authors.forename: J F
authors.initials: JF
authors.lastname: Nomdedéu
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019070:Cell Lineage; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000473:pathology*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D012008:Recurrence; D012074:Remission Induction; D013601:T-Lymphocytes / Q000473:pathology*