Structure and function of clostridial phospholipases C.
A range of clostridial species produce phospholipases C. The zinc metallo phospholipases C have related sequences but different properties. All of these enzymes may be arranged, like alpha-toxin as two-domain proteins. Differences in enzymatic, haemolytic and toxic properties may be explained by differences in amino acids at key positions.
Jepson
M
M
Defence Evaluation and Research Agency, CBD, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Titball
R
R
D000595:Amino Acid Sequence; D002462:Cell Membrane / Q000378:metabolism; D003013:Clostridium / Q000201:enzymology* / Q000378:metabolism; D008969:Molecular Sequence Data; D010743:Phospholipids / Q000378:metabolism; D017434:Protein Structure, Tertiary; D010738:Type C Phospholipases / Q000737:chemistry / Q000378:metabolism
D010743:Phospholipids; D010738:Type C Phospholipases