title: [Differences in hemodynamic effects of amrinone, milrinone and olprinon after cardiopulmonary bypass in valvular cardiac surgery].
abstract: The differences in hemodynamic effects of amrinone, milrinone and olprinone were evaluated in 46 patients for valvular cardiac surgery after cardiopulmonary bypass (CPB). Patients were randomly allocated to three groups; group A with amrinone infusion (17 patients); group M with milrinone infusion (15 patients); and group O with olprinone infusion (14 patients). Each drug was administrated as a single dose into the venous reservoir of the CPB circuit 15 min prior to the end of emergence from CPB, followed by continuous infusion. Hemodynamic parameters were measured at the time of preCPB (C0), just after the end of CPB (C1), one hour after the termination of CPB (C2) and after the chest closure (C3). Catecholamines were used in order of dopamine, norepinephrine and dobutamine. These doses were modulated to maintain the cardiac index > 3.0 l.min-1.m-2 by each anesthesiologist. Hemodynamic parameters (at C0, C1, C2 and C3) and the doses of cathecholamine (at C1, C2 and C3) were compared among the 3 drugs. The systolic blood pressure in group M was significantly higher than that of group A and group O after chest closure. In group M and A, the systolic blood pressure showed a significant increase after CPB. On the other hand, the systolic blood pressure showed no significant change in group O after CPB. Three drugs showed no significant difference in the dosages of catecholamines used.
authors.affiliation: Department of Anesthesiology, Nara Medical University, Kashihara.
authors.forename: K
authors.initials: K
authors.lastname: Sha
authors.forename: M
authors.initials: M
authors.lastname: Shimokawa
authors.forename: K
authors.initials: K
authors.lastname: Ishimaru
authors.forename: Y
authors.initials: Y
authors.lastname: Kawaraguchi
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: F
authors.initials: F
authors.lastname: Yanaidani
authors.forename: K
authors.initials: K
authors.lastname: Kitaguchi
authors.forename: H
authors.initials: H
authors.lastname: Furuya
mesh_terms: D000368:Aged; D000676:Amrinone / Q000008:administration & dosage / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass; D005260:Female; D006349:Heart Valve Diseases / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D020105:Milrinone / Q000008:administration & dosage / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011182:Postoperative Care; D011728:Pyridones / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D007093:Imidazoles; D010726:Phosphodiesterase Inhibitors; D011728:Pyridones; C059498:olprinone; D020105:Milrinone; D000676:Amrinone