[Neopterin: new immunological marker of autoimmune rheumatic disease].
Serum neopterin (SN), concentration of soluble (s) TNF-receptors (R) with molecular mass 55 kD and sIL-2R, C-reactive protein (CRP), Willebrand factor antigen (WF Ag) were measured in enzyme immunoassay (EIA) or radioimmunoassay (BRAHMS, Berlin, Germany) in 189 patients with autoimmune rheumatic diseases: 52 patients with systemic lupus erythematosus (SLE), 67 patients with rheumatoid arthritis (RA), 44 patients with polymyositis/dermatomyositis and 26 patients with Wegener granulomatosis. SN appeared elevated in autoimmune rheumatic diseases correlating with the disease activity and concentrations of sTNF R and sIL 2R. Assay for neopterin is clinically essential for examination of the immunopathological process activity, prediction of the outcomes, better knowledge about cytokine synthesis profile in autoimmune rheumatic diseases.
Nasonov
E L
EL
Samsonov
M Iu
MIu
Tilz
G
G
Fuchs
D
D
D000328:Adult; D001327:Autoimmune Diseases / Q000097:blood* / Q000150:complications / Q000276:immunology*; D015415:Biomarkers; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000097:blood*; D011379:Prognosis; D011863:Radioimmunoassay; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D012016:Reference Values; D012216:Rheumatic Diseases / Q000097:blood* / Q000150:complications / Q000276:immunology*; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D015415:Biomarkers; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D019798:Neopterin