title: [Action of sotalol on high-amplification electrocardiogram].
abstract: D,l sotalol is an antiarrhythmic widely used for treating ventricular excitability, especially ventricular tachycardia (VT). The means of assessing its efficacy is 24 hour Holter monitoring and programmed ventricular stimulation. High amplification ECG has also been proposed for predicting the effects of the drug on the induction of VT. The aim of this study was to assess the results of high amplification ECG before and after taking sotalol and to compare them with those of programmed ventricular stimulation. This study was performed in 24 patients with spontaneous and inductible ventricular tachycardia due to ischaemic heart disease. The two investigations were performed under basal conditions and after treatment with 160 to 320 mg/day of d,l-sotalol for 8 days. Nine patients had VT which could not be induced after treatment. In the other 15 cases, the VT remained inducible and was not significantly slowed. Analysis of different parameters of high amplification ECG, the QRS duration, RMS 40 and LAS did not show any difference after treatment in cases with inducible VT or VT suppressed by treatment. In conclusion, d,l sotalol, even at antiarrhythmic doses, does not seem to change the parameters of high amplification ECG, and it is therefore not necessary to stop treatment to carry out this investigation. Moreover, it was impossible to predict the effect of d,l sotalol on VT by high amplification ECG.
authors.affiliation: Service de cardiologie, CHU, Vandoeuvre.
authors.forename: B
authors.initials: B
authors.lastname: Brembilla-Perrot
authors.forename: P
authors.initials: P
authors.lastname: Houriez
authors.forename: J P
authors.initials: JP
authors.lastname: Preiss
authors.forename: O
authors.initials: O
authors.lastname: Claudon
authors.forename: D
authors.initials: D
authors.lastname: Beurrier
authors.forename: A
authors.initials: A
authors.lastname: Terrier de la Chaise
authors.forename: P
authors.initials: P
authors.lastname: Louis
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013015:Sotalol / Q000494:pharmacology*; D017180:Tachycardia, Ventricular / Q000503:physiopathology*
chemical_list: D000889:Anti-Arrhythmia Agents; D013015:Sotalol