Immunology of Helicobacter pylori and prospects for vaccine.
Since the initial discovery of H. pylori by Marshall and Warren 17 years ago, much progress has been made in treating this infection. However, as we enter the millennium, H. pylori infection continues to be one of the most common infections of mankind. In addition, eradication of H. pylori still requires multiple antimicrobial agents. A better understanding of the host immune response to H. pylori infection should allow investigators to develop immunotherapies to prevent the acquisition of infection and eradicate existing chronic H. pylori infection.
Blanchard
T G
TG
Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
Czinn
S J
SJ
D000818:Animals; D001428:Bacterial Vaccines / Q000494:pharmacology*; D016481:Helicobacter Infections / Q000276:immunology / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D051379:Mice; D011322:Primary Prevention / Q000379:methods; D012680:Sensitivity and Specificity
D001428:Bacterial Vaccines