E2F transcription factors are differentially expressed in murine gametes and early embryos.
We have examined the murine genes encoding transcription factors E2F1, -3, -5 and -6 in gametes and early embryos. All genes are expressed as maternal transcripts and all are efficiently transcribed after the blastocyst stage. Between those two stages, each E2F mRNA is transcribed with a distinctive and unique pattern. E2F proteins are also differentially expressed and compartmentalized in pre-implantation embryos.
Palena
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Centro di Genetica Evoluzionistica CNR, c/o Dipartimento di Genetica e Biologia Molecolare, Università "La Sapienza", Via degli Apuli 4, 00185, Roma, Italy.
Mangiacasale
R
R
Magnano
A R
AR
Barberi
L
L
Giordano
R
R
Spadafora
C
C
Lavia
P
P
D016475:3T3 Cells; D000818:Animals; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D050699:E2F3 Transcription Factor; D050700:E2F5 Transcription Factor; D050701:E2F6 Transcription Factor; D005314:Embryonic and Fetal Development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors / Q000235:genetics*
C533431:Arid4a protein, mouse; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D050699:E2F3 Transcription Factor; D050700:E2F5 Transcription Factor; D050701:E2F6 Transcription Factor; C491744:E2F6 protein, human; C493754:E2f1 protein, mouse; C490840:E2f3 protein, mouse; C490490:E2f5 protein, mouse; C111236:E2f6 protein, mouse; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors