Chronic parvovirus B-19 meningoencephalitis with additional detection of Epstein-Barr virus DNA in the cerebrospinal fluid of an immunocompetent patient.
Parvovirus B19 DNA was detected by polymerase chain reaction in the brain biopsy specimen from a 67-year-old immunocompetent woman with severe chronic lymphocytic meningoencephalitis. In addition to parvovirus B19, Epstein-Barr virus DNA was identified in the CSF. Genomic material from Epstein-Barr virus was absent in the brain tissue. Clinical symptoms and CSF pleocytosis improved under long-term corticosteroid-treatment. The aetio-pathogenetic role of parvovirus B19 and the possible meaning of the additionally detected Epstein-Barr virus DNA are discussed.
Druschky
K
K
Department of Neurology, University of Erlangen-Nuernberg, Germany.
Walloch
J
J
Heckmann
J
J
Schmidt
B
B
Stefan
H
H
Neundörfer
B
B
D000368:Aged; D001706:Biopsy; D001921:Brain / Q000473:pathology / Q000821:virology; D002908:Chronic Disease; D004279:DNA, Viral / Q000134:cerebrospinal fluid; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007121:Immunocompetence; D008587:Meningitis, Viral / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D010322:Parvoviridae Infections / Q000175:diagnosis* / Q000276:immunology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*
D004279:DNA, Viral