The time of tumor cell division and death depends on the site of growth.
We show here, for the first time, in two very different murine tumors, a mammary one (ectoderm) and a lung one (endoderm), that: tumors have day/night differences of spontaneous apoptosis additional to the well-known circadian rhythm of mitosis. The times of maximal and minimal mitosis and apoptosis changed for a tumor cell line when growing in different organs (as metastasis) or anatomical sites. Both tumor lines, have identical circadian curves when growing in a specific organ or anatomical site. The peaks of apoptosis match with the valleys of mitosis and vice versa.
Colombo
L L
LL
Area Investigacion, Instituto de Oncologia, A.H. Roffo, Univ. Buenos Aires, C1417DTB Buenos Aires, Argentina. lucascol@mail.fmed.uba.ar
Mazzoni
E O
EO
Meiss
R P
RP
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000502:physiology*; D009368:Neoplasm Transplantation; D010529:Peritoneal Cavity / Q000473:pathology; D013154:Spleen / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000473:pathology*