title: Regulation of septation: a novel role for SerC/PdxF in Salmonella?
abstract: The sfiW locus of Salmonella enterica, previously identified by mutations that suppress the cell division defect of His-constitutive (His(c)) strains, corresponds to serC, the bifunctional gene for phosphoserine-oxoglutarate aminotransferase (SerC) and 2-ketoerythroic acid 4-phosphate transaminase (PdxF). SerC- mutants form small, nearly spherical cells in a wild-type (His+) background, suggesting that the SerC/PdxF product acts as a septation antagonist. Suppression of His(c) filamentation by serC mutations may be explained by loss of the anti-septation activity of SerC/PdxF. The isolation of serC alleles that have lost their biosynthetic activities but are still able to inhibit septum formation suggests that the anti-septation activity of the SerC/PdxF product is unrelated to its known roles in serine and pyridoxine biosynthesis.
authors.affiliation: Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Mouslim
authors.forename: D A
authors.initials: DA
authors.lastname: Cano
authors.forename: A
authors.initials: A
authors.lastname: Flores
authors.forename: J
authors.initials: J
authors.lastname: Casadesús
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000378:metabolism; D002455:Cell Division / Q000235:genetics; D002473:Cell Wall / Q000737:chemistry / Q000235:genetics; D003001:Cloning, Molecular; D004251:DNA Transposable Elements; D029968:Escherichia coli Proteins; D006602:Hexosyltransferases; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D009154:Mutation; D046915:Penicillin-Binding Proteins; D010457:Peptidoglycan / Q000737:chemistry; D010458:Peptidyl Transferases; D019779:Salmonella enterica / Q000166:cytology* / Q000235:genetics* / Q000648:ultrastructure; D017421:Sequence Analysis; D000637:Transaminases / Q000235:genetics* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D004251:DNA Transposable Elements; D029968:Escherichia coli Proteins; D009097:Multienzyme Complexes; D046915:Penicillin-Binding Proteins; D010457:Peptidoglycan; D000445:Aldehyde Oxidoreductases; C066236:erythrose 4-phosphate dehydrogenase, E coli; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; C414595:2-ketoerythroic acid 4-phosphate aminotransferase; D000637:Transaminases; C022393:phosphoserine aminotransferase; D002267:Muramoylpentapeptide Carboxypeptidase