Prospective and randomized study of gabexate mesilate for the treatment of severe acute pancreatitis with organ dysfunction.
OBJECTIVE
Exaggerated production of various proteases may account for the late presence of organ dysfunction in acute pancreatitis. This study examined the effects of early administration of gabexate mesilate on the condition of patients with severe acute pancreatitis and organ dysfunctions.


METHODS
Fifty-two patients with acute pancreatitis and organ dysfunction were enrolled. The treatment group included 26 patients receiving intravenous gabexate mesilate infusion at a dose of 100 mg/hr for 7 days. APACHE-II score, clinical and biochemical parameters were monitored intensively.


RESULTS
Coagulopathy ileus, and abdominal pain was significantly improved with gabexate mesilate. Gabexate mesilate reduced the necessity for surgical intervention and peritoneal lavage. The 7-day-mortality and 90-day-mortality rates were also significantly reduced with gabexate mesilate therapy.


CONCLUSIONS
There are strong indications from this study that early intravenous gabexate mesilate infusion results in improved survival in acute pancreatitis with organ dysfunctions.
Chen
H M
HM
Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University School of Medicine, Taipei, Taiwan. ming1838@yahoo.com
Chen
J C
JC
Hwang
T L
TL
Jan
Y Y
YY
Chen
M F
MF
D000328:Adult; D005260:Female; D016670:Gabexate / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000188:drug therapy*; D019283:Pancreatitis, Acute Necrotizing / Q000188:drug therapy*; D011446:Prospective Studies; D015842:Serine Proteinase Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
D015842:Serine Proteinase Inhibitors; D016670:Gabexate