title: Hydrogen bonding in salicylsalicylic acid (salsalate) crystals.
abstract: An X-ray crystallographic study of the drug salsalicylic acid (salsalate) has been performed. Crystal formation of the drug is influenced by both inter- and intra-molecular hydrogen bonding. In addition an OH group in salsalate can occupy alternate ortho positions resulting in two hydrogen bonding motifs within a single crystal.
authors.affiliation: School of Pharmacy, The Robert Gorrdon University, Aberdee, UK. p.j.cox@rgu.ac.uk
authors.forename: P J
authors.initials: PJ
authors.lastname: Cox
authors.forename: G I
authors.initials: GI
authors.lastname: Gilmour
authors.forename: S M
authors.initials: SM
authors.lastname: MacManus
mesh_terms: D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D012459:Salicylates / Q000737:chemistry*
chemical_list: D012459:Salicylates; C014182:salicylsalicylic acid