Clinical symptoms of acute coronary insufficiency correlate with GP-IIIa genotype of integrin beta-subunit.
Studies of the clinical course of acute coronary insufficiency (progressive angina and myocardial infarction) in patients carrying a mutant allele of the Pl-A(II) gene encoding integrin GPIIIa beta-subunit revealed significant differences in the incidence of some clinical signs in comparison with patients homozygous for the normal Pl-A(I) allele.
Maksimenko
L V
LV
Department of Biology and General Genetics, Russian University of People Friendship, Moscow.
Moiseeva
T Y
TY
Tugarinova
G V
GV
Karpova
E V
EV
Frolov
V A
VA
Itkes
A V
AV
D015703:Antigens, CD / Q000235:genetics*; D015415:Biomarkers / Q000032:analysis; D004247:DNA / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D039661:Integrin beta3; D008297:Male; D009031:Moscow; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D021122:Protein Subunits
D015703:Antigens, CD; D015415:Biomarkers; D039661:Integrin beta3; D010980:Platelet Membrane Glycoproteins; D021122:Protein Subunits; D004247:DNA