title: Nasal polyposis: clinical course during 20 years.
abstract: BACKGROUND
  The etiology of nasal polyposis is mainly unknown although it has been connected with many clinical conditions. The long-term clinical course of nasal polyposis is largely unknown, because long-term followup studies on the recurrence of nasal polyposis have rarely been reported.
  
  
  OBJECTIVE
  The aim of the study was to find out the clinical course of nasal polyposis over a long period of time.
  
  
  METHODS
  Our report describes a 20-year follow-up study of 41 patients with nasal polyps. These patients had surgery for nasal polyp disease 20 years previously and they were initially grouped according to occurrence of (1) acetylsalicylic acid (ASA) intolerance, (2) atopic allergy (AT), and (3) intrinsic allergy-like disease (INTR). Patients were now re-examined, sinus computed tomography (CT) scanning was made, and a biopsy from polyp or from mucosa of the middle turbinate was taken.
  
  
  RESULTS
  Anterior rhinoscopy revealed polyps in 35 of 41 patients. Thus nasal polyposis was still active in 85% of patients after 20 years. Mucosal changes in paranasal sinuses were found in every patient. Anosmia or hyposmia was found in 61% (25/41) of the patients. Eight patients had had 11 or more surgical operations during the 20-year period. Of these, 88% (7/8) belonged to the ASA group. Bronchial asthma was found in all ASA intolerance patients (11/11), and in 36% (4/11) of AT and in 16% (3/19) of INTR patients, respectively.
  
  
  CONCLUSIONS
  Because of the high recurrence tendency and insidious symptoms of nasal polyposis, patients will require followup for the rest of their lives.
authors.affiliation: Department of Otorhinolaryngology, Helsinki University Central Hospital, Finland. doctor.vento@fimnet.fi
authors.forename: S I
authors.initials: SI
authors.lastname: Vento
authors.forename: L O
authors.initials: LO
authors.lastname: Ertama
authors.forename: M L
authors.initials: ML
authors.lastname: Hytönen
authors.forename: C H
authors.initials: CH
authors.lastname: Wolff
authors.forename: C H
authors.initials: CH
authors.lastname: Malmberg
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000494:pharmacology; D001706:Biopsy; D004361:Drug Tolerance; D004802:Eosinophilia / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology; D009298:Nasal Polyps / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D000857:Olfaction Disorders / Q000209:etiology; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging; D011859:Radiography; D012086:Reoperation / Q000009:adverse effects; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D001241:Aspirin