title: Effect of antiandrogen, chlormadinone acetate (CMA), in canine spontaneous benign prostatic hyperplasia (BPH).
abstract: The effect of synthetic steroidal antiandrogen, chlormadinone acetate (CMA), on spontaneous benign prostatic hyperplasia (BPH) in dogs was investigated. Male beagle dogs (5-8 years old) were divided into three experimental groups. Group 1 consisted of untreated controls. Groups 2 and 3 received CMA 0.03, and 0.1 mg/kg/day, p.o., respectively, for 6 months. In group 1, glandular hyperplasia of the prostate was clearly detected. In groups 2 and 3, CMA produced marked atrophy of the glandular epithelium. In addition, a histopathological study showed that CMA medication for 6 months exerted no effect on the testes and adrenals or on immunoreactive LH- and ACTH- cells of the anterior pituitary glands. Therefore, it is suggested that CMA (0.03 and 0.1 mg/kg) causes regression of spontaneous canine BPH without any histopathological effects on the testes, adrenals or anterior pituitary LH- and ACTH-cells.
authors.affiliation: Safety Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Murakoshi
authors.forename: R
authors.initials: R
authors.lastname: Ikada
authors.forename: M
authors.initials: M
authors.lastname: Tagawa
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000311:Adrenal Glands / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002715:Chlormadinone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D007986:Luteinizing Hormone / Q000032:analysis; D008297:Male; D009929:Organ Size; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000473:pathology; D011467:Prostate / Q000187:drug effects / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D013737:Testis / Q000187:drug effects / Q000473:pathology
chemical_list: D000726:Androgen Antagonists; D002715:Chlormadinone Acetate; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone