[Therapy-resistant ventricular tachycardia in a woman with primary cardiac non-Hodgkin lymphoma].
METHODS
A 65-year-old woman had suffered from relapsing ventricular tachycardias (VT) since 1996.


RESULTS
Physical examination was normal. An arrhythmogenic substrate was found in the right ventricular outflow tract by electrophysiological examination. Nuclear magnetic resonance imaging (MRI) showed an infiltration of the right heart. Myocardial biopsy revealed a high-grade centroblastic non Hodgkin lymphoma. The patient was now transferred to our hospital for further treatment. Lactate dehydrogenase was elevated (2,030 U/l). Echocardiography showed a thickened and more reflecting right ventricular myocardium. Bone marrow aspiration and MRI/computed tomography of abdomen and thorax excluded a generalized stage. Ventricular tachycardias were caused by a primary cardiac lymphoma.


METHODS
Combined radio-chemotherapy succeeded in complete remission. High-frequency ablation and amiodarone failed. Although MRI showed no more vital lymphoma after the combined radio-chemotherapy the patient suffered from spontaneous and symptomatic relapses of VT. Therefore this patient with primary cardiac lymphoma was the first in literature to get a defibrillator (ICD). The incidence of VT decreased and up to now the patient showed no relapse of the non Hodgkin lymphoma (follow-up 23 months).
Kohl
O
O
Medizinische Klinik I-Kardiologie und Angiologie, Zentrum für Innere Medizin.
Hölschermann
H
H
Pralle
H
H
von Lieven
H
H
Bohle
R M
RM
Thormann
J
J
Waldecker
B
B
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D017147:Defibrillators, Implantable; D003937:Diagnosis, Differential; D004562:Electrocardiography; D005260:Female; D006338:Heart Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009206:Myocardium / Q000473:pathology*; D013610:Tachycardia / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome