Possible activation of auto-immune thyroiditis from continuous subcutaneous infusion of genapol-containing insulin.
A case of a type 1 diabetic woman with auto-immune thyroiditis is reported, in whom repeated exposure to insulin containing Genapol(R) (polyethylen-polypropylenglycol) over 3 years reproducibly parallels with an increase of serum TSH (thyroid-stimulating hormone) above the normal limit. Previously, adverse effects of Genapol(R) insulin have been related to its intraperitoneal application, and thought to be restricted to anti-insulin-immunity; activating effects on thyroid auto-immunity have been repeatedly disputed. We suggest that Genapol(R) insulin should be replaced by other insulin preparations with a better safety record.
Chantelau
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Diabetesambulanz MNR-Klinik, Heinrich-Heine-Universität Dusseldorf Postfach 10 10 07 D-40001 Dusseldorf.
D001323:Autoantibodies / Q000097:blood; D002626:Chemistry, Pharmaceutical; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007332:Insulin Infusion Systems; D007453:Iodide Peroxidase / Q000276:immunology; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000009:adverse effects*; D013501:Surface-Active Agents / Q000009:adverse effects; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D001323:Autoantibodies; D013501:Surface-Active Agents; D014284:Triiodothyronine; D011092:Polyethylene Glycols; D013972:Thyrotropin; D013954:Thyroglobulin; C116996:genapol X 080; D007453:Iodide Peroxidase; D013974:Thyroxine