title: Cobalt-catalyzed alkyne-nitrile cyclotrimerization to form pyridines in aqueous solution.
abstract: A new, water-soluble cobalt(I) catalyst has been used in the aqueous, chemospecific, cyclotrimerization of one nitrile with two alkynes for the synthesis of highly functionalized pyridines. Several different functional groups are well incorporated in this transformation, including unprotected alcohols, ketones, and amines. Double isotopic crossover data, as well as nitrile dependence on the rate of product formation, suggest associative rate-determining coordination of the nitrile.
authors.affiliation: Department of Chemistry, Washington State University, P.O. Box 644630, Pullman, Washington 99164-6430, USA. anson.fatland@colorado.edu
authors.forename: A W
authors.initials: AW
authors.lastname: Fatland
authors.forename: B E
authors.initials: BE
authors.lastname: Eaton
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt; D003500:Cyclization; D009682:Magnetic Resonance Spectroscopy; D009570:Nitriles / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis*; D012996:Solutions
chemical_list: D000480:Alkynes; D009570:Nitriles; D011725:Pyridines; D012996:Solutions; D003035:Cobalt