Allele NAT2*5 determines resistance to bronchial asthma in children.
NAT2*5 allele was found in 54.8% healthy children and 35.9% children with bronchial asthma, i.e. the risk of bronchial asthma was considerably lower in individuals carrying NAT2*5 allele. NAT2*5 allele manifests itself in both homo- and heterozygous states.
Makarova
S I
SI
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. imbb@cyber.ma.nsc.ru
Vavilin
V A
VA
Lyakhovich
V V
VV
Gavalov
S M
SM
D000293:Adolescent; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D001249:Asthma / Q000209:etiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D014028:Tobacco Smoke Pollution
D014028:Tobacco Smoke Pollution; D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human