title: Factors related to outcome of salvage therapy for isolated cervical recurrence of squamous cell carcinoma in the previously treated neck: a multi-institutional study.
abstract: OBJECTIVE
  The goal was to identify factors associated with the outcome of salvage therapy for patients with isolated cervical recurrences of squamous cell carcinoma in the previously treated neck (ICR-PTN).
  
  
  METHODS
  A tumor registry search for ICR-PTN patients was performed at 7 participating institutions, and the charts were reviewed. Kaplan-Meier plots for survival and time until re-recurrence were used to evaluate the significance of associated variables.
  
  
  RESULTS
  Median survival and time until re-recurrence were both 11 months. Survival was better in patients with the following characteristics: nonsurgical initial neck treatment, negative initial disease resection margins, no history of prior recurrence, ipsilateral location of the ICR-PTN relative to the primary, and use of surgical salvage.
  
  
  CONCLUSIONS
  By pooling the experience of 7 US tertiary care medical centers, we have identified 5 factors that are associated with outcome of salvage therapy for ICR-PTN.
  
  
  CONCLUSIONS
  Consideration of these factors, as well as the reviewed literature, should facilitate patient selection for salvage protocols.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis 46202-5230, USA.
authors.forename: B J
authors.initials: BJ
authors.lastname: Krol
authors.forename: P D
authors.initials: PD
authors.lastname: Righi
authors.forename: J A
authors.initials: JA
authors.lastname: Paydarfar
authors.forename: E T
authors.initials: ET
authors.lastname: Cheng
authors.forename: R M
authors.initials: RM
authors.lastname: Smith
authors.forename: D C
authors.initials: DC
authors.lastname: Lai
authors.forename: V
authors.initials: V
authors.lastname: Bhargava
authors.forename: J F
authors.initials: JF
authors.lastname: Piccirillo
authors.forename: J T
authors.initials: JT
authors.lastname: Hayes
authors.forename: A J
authors.initials: AJ
authors.lastname: Lue
authors.forename: R L
authors.initials: RL
authors.lastname: Scher
authors.forename: E C
authors.initials: EC
authors.lastname: Weisberger
authors.forename: K M
authors.initials: KM
authors.lastname: Wilson
authors.forename: L E
authors.initials: LE
authors.lastname: Tran
authors.forename: N
authors.initials: N
authors.lastname: Rizk
authors.forename: P K
authors.initials: PK
authors.lastname: Pellitteri
authors.forename: D J
authors.initials: DJ
authors.lastname: Terris
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D002423:Cause of Death; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D011336:Probability; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D016879:Salvage Therapy; D015996:Survival Rate