title: [Comparative study of intestinal anastomosis with manual suture and biofragmentable ring in dogs under corticosteroid administration].
abstract: BACKGROUND
  This study analyzed intestinal anastomoses by manual suture and by compression with biofragmentable ring under delay of cicatrization administering parenteral corticoids.
  
  
  METHODS
  Twenty dogs were divided into two groups: control and test, the latter submitted to intramuscular administration of hydrocortisone hemisuccinate, 25 to 33 mg/kg/day, on the 30th preoperative and 7th postoperative days. During surgery, each animal underwent two colon sections with anastomosis by manual suture in a single extramucous plane and compression with biofragmentable ring. The animals were sacrificed 7 days after the procedure to evaluate the anastomoses.
  
  
  RESULTS
  In the postoperative period, one death occurred in the test group and two in the control group, caused by nonblocked fistula in the anastomoses by ring compression. Statistically, there was a similar incidence of adherences, fistulas, afferent dilatation and obstruction using comparison methods. On microscopy, deficiency in mucous regeneration of the anastomoses by compression was observed. Computerized histological analysis evidenced in the anastomoses by compression, a greater inflammatory reaction, greater edema of the submucous membrane and enlarged scars.
  
  
  CONCLUSIONS
  It was concluded that, with the biofragmentable ring, in colonic anastomosis under delay of cicatrization induced by corticoids, similar results to manual suture regarding to postoperative complications incidence were obtained; ring, however, determined worse mucous regeneration and greater cicatricial inflammatory reaction.
authors.affiliation: Disciplina de Gastroenterologia Cirúrgica da Unifesp, Escola Paulista de Medicina, São Paulo.
authors.forename: L C
authors.initials: LC
authors.lastname: Fernandes
authors.forename: D
authors.initials: D
authors.lastname: Matos
authors.forename: M D
authors.initials: MD
authors.lastname: Novelli
authors.forename: S B
authors.initials: SB
authors.lastname: Kim
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D004285:Dogs; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007422:Intestines / Q000601:surgery*; D008297:Male; D015596:Nutrition Assessment; D011183:Postoperative Complications; D013536:Suture Techniques; D014945:Wound Healing / Q000187:drug effects
chemical_list: C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone