Immunology of cancer cervix.
It is not clear how much genetic factor is responsible for causing cervical cancer, but certainly there has some mutation abnormality in the suppressive p53 gene which is to be proved beyond doubt. In addition to this, there are some environmental factors which make insults on cervical epithelium. Immunology of cancer cervix is well represented by (1) immunology of cancer, (2) immunology of virally controlled antigen and (3) cancer cervix antigen markers. The cancer is an example of transplantation immunology changes in the surface of tumour cells during replication. Human papillomavirus (HPV) DNA has been shown to be associated with high grade cervical intra-epithelial neoplasia (CIN). Squamous cell carcinoma antigen has been investigated for predictive value in cancer cervix. Colony stimulating factor-1 causes monocytic cells aggregation in neoplastic area and plays as initiators of the sequence of inflammation up to neoplasia.
Dasgupta
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D000956:Antigens, Viral / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000276:immunology; D030361:Papillomavirus Infections / Q000276:immunology; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000276:immunology*; D002578:Uterine Cervical Dysplasia / Q000276:immunology
D000956:Antigens, Viral