title: Aspergillus terreus infections in haematological malignancies: molecular epidemiology suggests association with in-hospital plants.
abstract: During a three-year period nine patients with haematological diseases after myeloablative chemotherapy died from invasive fungal infections caused by Aspergillus terreus. The hospital inanimate environment was monitored and A. terreus was cultured from potted plants in the vicinity of the patients. The patients (N = 14) and the environmental isolates (N = 2) were fingerprinted by RAPD-PCR with four different primers. Based on RAPD patterns the patients' isolates were differentiated into five different types; the environmental isolates represented two types. The isolates of four patients were identical to those found in the environment. Five additional patients were infected by RAPD types not found in the environment. One patient was infected with two different types. The data indicate a hospital-acquired infection in many of the patients and underline the need for careful environmental monitoring of units in which high-risk patients are housed.
authors.affiliation: Institute of Hygiene, University of Innsbruck, Austria. Floerl@uibk.ac.at
authors.forename: C
authors.initials: C
authors.lastname: Lass-Flörl
authors.forename: P
authors.initials: P
authors.lastname: Rath
authors.forename: D
authors.initials: D
authors.lastname: Niederwieser
authors.forename: G
authors.initials: G
authors.lastname: Kofler
authors.forename: R
authors.initials: R
authors.lastname: Würzner
authors.forename: A
authors.initials: A
authors.lastname: Krezy
authors.forename: M P
authors.initials: MP
authors.lastname: Dierich
mesh_terms: D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications / Q000453:epidemiology*; D001230:Aspergillus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D003428:Cross Infection / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D016172:DNA Fingerprinting; D017931:DNA Primers; D004271:DNA, Fungal / Q000737:chemistry; D004196:Disease Outbreaks; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008172:Lung Diseases, Fungal / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology; D010944:Plants / Q000382:microbiology; D016133:Polymerase Chain Reaction; D019105:Random Amplified Polymorphic DNA Technique; D012988:Soil Microbiology
chemical_list: D017931:DNA Primers; D004271:DNA, Fungal