Hydrogen bonding in salicylsalicylic acid (salsalate) crystals.
An X-ray crystallographic study of the drug salsalicylic acid (salsalate) has been performed. Crystal formation of the drug is influenced by both inter- and intra-molecular hydrogen bonding. In addition an OH group in salsalate can occupy alternate ortho positions resulting in two hydrogen bonding motifs within a single crystal.
Cox
P J
PJ
School of Pharmacy, The Robert Gorrdon University, Aberdee, UK. p.j.cox@rgu.ac.uk
Gilmour
G I
GI
MacManus
S M
SM
D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D012459:Salicylates / Q000737:chemistry*
D012459:Salicylates; C014182:salicylsalicylic acid