title: Long-term follow-up of vitamin B(6)-responsive West syndrome.
abstract: We performed a clinical and electroencephalographic follow-up study on 25 patients with West syndrome that was responsive to vitamin B(6) (eight cryptogenic patients and 17 symptomatic patients) who were older than 3 years at the last follow-up. All cryptogenic patients and 13 symptomatic patients were seizure free at the last follow-up. All cryptogenic patients and seven symptomatic patients had intelligent quotient or developmental quotient scores of 75 or higher. The recurrence of clinical seizures was always associated with increases in epileptic discharges. We could successfully discontinue pyridoxal phosphate administration in four cryptogenic and four symptomatic patients who were 1 year, 8 months to 24 years old.
authors.affiliation: Department of Child Neurology, Okayama University Medical School, Okayama, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: T
authors.initials: T
authors.lastname: Ogino
authors.forename: T
authors.initials: T
authors.lastname: Asano
authors.forename: J
authors.initials: J
authors.lastname: Hattori
authors.forename: H
authors.initials: H
authors.lastname: Ohta
authors.forename: E
authors.initials: E
authors.lastname: Oka
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011736:Pyridoxine / Q000008:administration & dosage*; D013036:Spasms, Infantile / Q000188:drug therapy* / Q000209:etiology
chemical_list: D011736:Pyridoxine