Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells.
Two taxoids, taxinine NN-7 (1) and 3,11-cyclotaxinine NN-2 (2), were isolated from the neutral fraction of the EtOAc extract of a mixture of needles and young stems of Taxus cuspidata. The structures were determined by spectroscopic analysis. Both compounds showed some activity as modulators of multidrug-resistant tumor cells.
Kosugi
K
K
Graduate School of Science and Technology, Niigata University, Japan.
Sakai
J
J
Zhang
S
S
Watanabe
Y
Y
Sasaki
H
H
Suzuki
T
T
Hagiwara
H
H
Hirata
N
N
Hirose
K
K
Ando
M
M
Tomida
A
A
Tsuruo
T
T
D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D017239:Paclitaxel / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D043823:Taxoids; D014197:Trees / Q000737:chemistry*; D014407:Tumor Cells, Cultured
C419071:3,11-cyclotaxinine NN-2; D004224:Diterpenes; D043823:Taxoids; C419070:taxinine NN-7; D017239:Paclitaxel