title: Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP).
abstract: OBJECTIVE
  To investigate the associations between indices of adiposity and cardiovascular risk factors in individuals with an atherogenic lipoprotein phenotype (ALP).
  
  
  METHODS
  Fifty-five men, aged 34-69 y, body mass index (BMI) 22-35 kg/m2, with an ALP lipid profile (triglycerides (TG) 1.5-4.0 mmol/l, HDL<1.1 mmol/l; %LDL-3>40% total LDL).
  
  
  METHODS
  Each participant provided a fasting blood sample and underwent an 8 h postprandial assessment and had anthropometric measurements taken.
  
  
  METHODS
  BMI, waist circumference (W), waist-to-hip ratio (W/H), sum of skinfolds (SSK), fasting and postprandial concentrations of glucose, insulin and plasma lipids, post-heparin lipase activity, and apoE genotype.
  
  
  RESULTS
  The expected positive associations between BMI, W and SSK and fasting and postprandial insulin were observed (r=0.42-0.65). Little association between glucose responses and any measures of adiposity was evident. Unexpectedly, there were no positive associations between measures of central adiposity (W and W/H) and fasting and postprandial TG responses, with a trend towards negative associations in this study group (TG AUC vs W, r=-0.23, P=0.097; TG IAUC vs W/H, r=-0.26, P=0.068). Subgroup analysis indicated that lack of a positive association between central adiposity and postprandial TG values was more evident in those with one E4 allele (r=-0.42, P=0.077) relative to non-E4 carriers (r=-0.16, P=0.430). The expected positive associations between insulin and TG responses were not observed (r=-0.03 to -0.36).
  
  
  CONCLUSIONS
  In this ALP group the expected positive association between TG responses and a centralized distribution of body fat was not observed, particularly in individuals with an apoE4 genotype. Our findings are not in line with the view that there is a clear causal relationship between insulin resistance and the lipid abnormalities associated with ALP.
authors.affiliation: Department of Food Science and Technology, University of Reading, Whiteknights, UK. a.m.minihane@afnovell.reading.ac.uk
authors.forename: A M
authors.initials: AM
authors.lastname: Minihane
authors.forename: S
authors.initials: S
authors.lastname: Khan
authors.forename: P J
authors.initials: PJ
authors.lastname: Talmud
authors.forename: D L
authors.initials: DL
authors.lastname: Williams
authors.forename: J W
authors.initials: JW
authors.lastname: Wright
authors.forename: M C
authors.initials: MC
authors.lastname: Murphy
authors.forename: B A
authors.initials: BA
authors.lastname: Griffin
authors.forename: C M
authors.initials: CM
authors.lastname: Williams
mesh_terms: D000005:Abdomen; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D004739:England; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000235:genetics*; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D044465:White People / Q000235:genetics
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides