title: Highly oxidized cuparene-type sesquiterpenes from a mycelial culture of Flammulina velutipes.
abstract: Cuparene-type sesquiterpenes were isolated from a culture broth of Flammulina velutipes (Curt.:Fr.) Sing. Using spectroscopic methods (HR-MS, 1H and 13C NMR, and 2D NMR, spectroscopy), their structures were determined to be 2,3,4,5-tetrahydro-2,7-dihydroxy-5,8,10,10-tetramethyl-2,5-methano-1- benzoxepin and 5-methyl-2-(3-oxo-1,2,2-trimethylcyclopentyl)benzoquinone. Both showed antimicrobial activity against Cladosporium herharum and Bacillus subtilis.
authors.affiliation: Division of Environmental Resources, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan.
authors.forename: N K
authors.initials: NK
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Yamaji
authors.forename: S
authors.initials: S
authors.lastname: Tahara
authors.forename: Y
authors.initials: Y
authors.lastname: Fukushi
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001487:Basidiomycota / Q000737:chemistry* / Q000166:cytology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001584:Benzoxepins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: C419012:2,3,4,5-tetrahydro-2,7-dihydroxy-5,8,10,10-tetramethyl-2,5-methano-1- benzoxepin; C419013:5-methyl-2-(3-oxo-1,2,2-trimethylcyclopentyl)benzoquinone; D000890:Anti-Infective Agents; D016227:Benzoquinones; D001584:Benzoxepins; D012717:Sesquiterpenes