title: Antigen presentation in the lung.
abstract: Studies from our laboratory and elsewhere have implicated populations of dendritic cells in lung and airway tissues as key regulators of both qualitative and quantitative aspects of T cell responses to local antigenic challenge. Under steady state conditions, they are specialized for uptake of antigen, and require additional maturation signals for full expression of their T cell-stimulating activity. Their functional phenotype appears to be controlled via a complex series of interactions with both bone marrow-derived, mesenchymal, and possibly neuroendocrine cells; failure(s) in one or more of these regulatory interactions may be important etiologic and/or pathogenic factors in a variety of respiratory immunoinflammatory disease.
authors.affiliation: Division of Cell Biology, TVW Telethon Institute for Child Health Research, Perth, Australia. patrick@ichr.uwa.edu.au
authors.forename: P G
authors.initials: PG
authors.lastname: Holt
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008168:Lung / Q000276:immunology*; D016040:Lung Transplantation / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D016676:Macrophages, Alveolar / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000276:immunology; D012137:Respiratory System / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D023001:Transplantation Tolerance / Q000276:immunology