Prediction of dopamine transporter binding availability by genotype: a preliminary report.
OBJECTIVE
Evidence of a relationship between genotype and binding availability was assessed for the dopamine and serotonin transporter genes.


METHODS
The authors assessed dopamine transporter genotype at the SLC6A3 3' variable number of tandem repeats (VNTR) polymorphism and serotonin transporter genotype at the SLC6A4 promotor VNTR polymorphism in 30 healthy subjects who also underwent single photon emission computed tomography with [(123)I]beta-CIT.


RESULTS
Subjects homozygous for the 10-repeat allele at the SLC6A3 locus demonstrated significantly lower dopamine transporter binding than carriers of the nine-repeat allele. There was no effect of SLC6A4 genotype upon serotonin transporter binding.


CONCLUSIONS
These findings suggest that genetic variation at the SLC6A3 3' VNTR polymorphism may modify dopamine transporter function.
Jacobsen
L K
LK
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. leslie.jacobsen@yale.edu
Staley
J K
JK
Zoghbi
S S
SS
Seibyl
J P
JP
Kosten
T R
TR
Innis
R B
RB
Gelernter
J
J
D000328:Adult; D002352:Carrier Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D004247:DNA / Q000235:genetics; D004298:Dopamine / Q000235:genetics* / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism*; D026901:Membrane Transport Proteins; D018598:Minisatellite Repeats / Q000235:genetics; D009419:Nerve Tissue Proteins; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins; D015899:Tomography, Emission-Computed, Single-Photon
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493214:SLC6A3 protein, human; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA; D004298:Dopamine