Effects of milrinone on platelet aggregation in swine with pulmonary hypertension.
OBJECTIVE
The purpose of this study was to investigate whether the effect of milrinone on platelet aggregation was related to the selectivity of vasodilation vasculature in a swine model with PH.


METHODS
To induce pulmonary hypertension, we injected two sets of acid-washed glass beads in 15 swine, which were divided into two groups (those receiving milrinone or not) and compared with each other.


RESULTS
The induction of pulmonary hypertension decreased the platelet count and increased the plasma levels of thromboxane B2 and 6-keto-prostaglandin F1alpha.


CONCLUSIONS
A locally high concentration of prostaglandin I2, at least in part, may produce selectivity of vasodilation in the pulmonary vasculature.
Tanaka
H
H
Trauma and Critical Care Center and Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Tajimi
K
K
Miyajima
Y
Y
Kazama
M
M
Kobayashi
K
K
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001682:Biological Availability; D001784:Blood Gas Analysis; D006439:Hemodynamics; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D020105:Milrinone / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013552:Swine; D013929:Thromboxane B2 / Q000097:blood; D014664:Vasodilation / Q000187:drug effects*
D010975:Platelet Aggregation Inhibitors; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D020105:Milrinone