title: Clinical evidence for correlation of insufficient tissue oxygen supply (hypoxia) and tumor-associated proteolysis in squamous cell carcinoma of the head and neck.
abstract: Hypoxic tumors of patients with squamous cell carcinoma of the head and neck show a consistent trend towards poor treatment outcome. We now report that tumor hypoxia in these patients is correlated with elevated antigen content of the tumor-associated serine protease uPA (urokinase-type plasminogen activator), a marker of tumor cell invasion and metastasis.
authors.affiliation: Klinik und Poliklinik für Strahlentherapie und Radiologische Onkologie, Technische Universitat Munchen, Germany. Peter.Stadler@Irz.tum.de
authors.forename: P
authors.initials: P
authors.lastname: Stadler
authors.forename: H J
authors.initials: HJ
authors.lastname: Feldmann
authors.forename: C
authors.initials: C
authors.lastname: Creighton
authors.forename: H F
authors.initials: HF
authors.lastname: Zeilhoffer
authors.forename: V
authors.initials: V
authors.lastname: Zimmermann
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: M
authors.initials: M
authors.lastname: Molls
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis*
chemical_list: D014568:Urokinase-Type Plasminogen Activator