title: The use of recombinant human TSH in a patient with metastatic follicular carcinoma and insufficient endogenous TSH production.
abstract: We present a case of a patient suffering from metastatic differentiated thyroid carcinoma (DTC) and insufficient endogenous TSH production suspicious of secondary hypothyroidism. The use of recombinant human TSH (rhTSH) enabled us to administer a therapeutic activity of radioactive iodine (RAI) under maximal TSH-stimulation, achieving a marked decrease in thyroglobulin accompanied by a clinical improvement.
authors.affiliation: Department of Nuclear Medicine, University of Wuerzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Luster
authors.forename: W
authors.initials: W
authors.lastname: Reinhardt
authors.forename: C
authors.initials: C
authors.lastname: Korber
authors.forename: M
authors.initials: M
authors.lastname: Lassmann
authors.forename: H
authors.initials: H
authors.lastname: Haenscheid
authors.forename: U
authors.initials: U
authors.lastname: Michalowski
authors.forename: J
authors.initials: J
authors.lastname: Rendl
authors.forename: E
authors.initials: E
authors.lastname: Eising
authors.forename: K
authors.initials: K
authors.lastname: Mann
authors.forename: C
authors.initials: C
authors.lastname: Reiners
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D001859:Bone Neoplasms / Q000556:secondary; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000209:etiology; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D012888:Skull Neoplasms / Q000556:secondary / Q000601:surgery; D013964:Thyroid Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D013965:Thyroidectomy; D013972:Thyrotropin / Q000008:administration & dosage / Q000172:deficiency* / Q000627:therapeutic use*
chemical_list: D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin