title: Pulmonary endothelial permeability and circulating neutrophil-endothelial markers in patients undergoing esophagogastrectomy.
abstract: OBJECTIVE
  Esophagogastrectomy is an established surgical treatment for esophageal malignancy. The postoperative period may be complicated by the development of acute lung injury syndromes and thus, may provide a useful model in which to study the early pathogenic mechanisms of inflammatory lung injury.
  
  
  METHODS
  Open, prospective study.
  
  
  METHODS
  High dependency and intensive therapy units.
  
  
  METHODS
  Eight healthy male volunteers and 20 patients in the early postoperative period
  
  
  METHODS
  None.
  
  
  RESULTS
  The lung protein accumulation index (PAI) of radiolabeled transferrin was determined by using a portable, double-isotope system. The following circulating inflammatory markers-thought to reflect neutrophil-endothelial activation and injury including circulating neutrophil elastase-soluble L-, E-, and P-selectins and thrombomodulin and von Willebrand factor antigen were assayed from venous blood samples The PAI for healthy volunteers was median -0.5 (range, -1.73 to 0.27) x 10(-3)/min and for patients undergoing esophagogastrectomy -0.005 (range, -1.53 to 2.28) x 10(-3)/min. There was no statistical difference between the two groups. In the postesophagogastrectomy group, a significant elevation in circulating levels of neutrophil elastase, soluble P- and E-selectin, thrombomodulin, and von Willebrand factor antigen were observed relative to the control group but only circulating plasma elastase demonstrated a significant correlation with the PAI (r2 = .23, p =.03).
  
  
  CONCLUSIONS
  The data suggest patients undergoing esophagogastrectomy develop a inflammatory response but this is not a surrogate of permeability and other factors are likely to determine persistent injury to the alveolar-capillary barrier function in this patient group.
authors.affiliation: Department of Respiratory Medicine, Western General Hospital, Scotland.
authors.forename: P T
authors.initials: PT
authors.lastname: Reid
authors.forename: S C
authors.initials: SC
authors.lastname: Donnelly
authors.forename: I R
authors.initials: IR
authors.lastname: MacGregor
authors.forename: I S
authors.initials: IS
authors.lastname: Grant
authors.forename: E
authors.initials: E
authors.lastname: Cameron
authors.forename: W
authors.initials: W
authors.lastname: Walker
authors.forename: M V
authors.initials: MV
authors.lastname: Merrick
authors.forename: C
authors.initials: C
authors.lastname: Haslett
mesh_terms: D000368:Aged; D002199:Capillary Permeability / Q000276:immunology*; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D005743:Gastrectomy; D006801:Humans; D019272:Leukocyte Elastase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011183:Postoperative Complications / Q000175:diagnosis / Q000276:immunology*; D012016:Reference Values; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000276:immunology*; D019087:Selectins / Q000097:blood; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000276:immunology*; D018180:Thrombomodulin / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D019087:Selectins; D018180:Thrombomodulin; D014841:von Willebrand Factor; D019272:Leukocyte Elastase