title: Mechanisms of chronic rejection.
abstract: Chronic rejection remains the major obstacle to long-term allograft survival. Detailed understanding of putative etiologic risk factors, both antigen-dependent and -independent, is important for designing effective therapeutic strategies to ameliorate this process. Cell senescence may be an important factor in chronic rejection.
authors.affiliation: Surgical Research Laboratory, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Waaga
authors.forename: M
authors.initials: M
authors.lastname: Gasser
authors.forename: I
authors.initials: I
authors.lastname: Laskowski
authors.forename: N L
authors.initials: NL
authors.lastname: Tilney
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D006084:Graft Rejection / Q000209:etiology*; D006650:Histocompatibility Testing; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D012307:Risk Factors
chemical_list: D007519:Isoantigens