5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer.
The ability of 5-aminosalicylic acid and olsalazine to inhibit colonic aberrant crypts and tumors was investigated in 1,2-dimethylhydrazine-treated rats. The effect of these drugs on the rates of tumor apoptosis and proliferation was studied as potential mechanisms for their action. 5-Aminosalicylic acid reduced the number of aberrant crypt foci by over one third, while olsalazine had no effect on this parameter. However, both agents effectively reduced tumor number and load, increased the rate of tumor apoptosis, and reduced the rate of tumor cell proliferation. In conclusion, 5-aminosalicylic acid and olsalazine are both ultimately effective chemopreventive agents in this model; however, only 5-aminosalicylic acid inhibited the formation of aberrant crypt foci. The inhibitory effect of these agents in tumors is related to the inhibition of proliferation and the induction of apoptosis.
Brown
W A
WA
Monash University Department of Surgery, Alfred Hospital, Prahran, Victoria, Australia.
Farmer
K C
KC
Skinner
S A
SA
Malcontenti-Wilson
C
C
Misajon
A
A
O'Brien
P E
PE
D000636:Aminosalicylic Acids / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D015179:Colorectal Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D008297:Male; D019804:Mesalamine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000636:Aminosalicylic Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine; C032587:olsalazine