title: Assessment of the airway in obstructive sleep apnea syndrome with 3-dimensional airway computed tomography.
abstract: OBJECTIVE
  The goal was to evaluate 3-dimensional airway CT for upper airway assessment in obstructive sleep apnea syndrome (OSAS).
  
  
  METHODS
  Airway CT was obtained and 3-dimensional airway models were constructed prospectively for 40 patients with OSAS and 10 controls. Airway dimensions were correlated with polysomnography, and comparison was made between patients with and without OSAS.
  
  
  RESULTS
  OSAS patients had a mean respiratory distress index of 51.9 events per hour. The mean minimum cross-sectional area (XSA) in the neutral position was 67.1 mm(2). Minimum XSA decreased in both the inspiratory and expiratory phases to 16.3 mm(2) and 15.0 mm(2), respectively (P<0.001). Complete airway obstruction occurred in 1 or more phases of respiration in 28 patients. Neither airway XSA nor length of obstruction correlated with sleep apnea parameters. No statistically significant differences in airway dimensions were found between OSAS and control patients.
  
  
  CONCLUSIONS
  Airway CT demonstrates dynamic airway obstruction in OSAS but does not correlate well with clinically important disease parameters.
authors.affiliation: Division of Otolaryngology, Brigham and Women's Hospital, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: N
authors.initials: N
authors.lastname: Bhattacharyya
authors.forename: S P
authors.initials: SP
authors.lastname: Blake
authors.forename: M P
authors.initials: MP
authors.lastname: Fried
mesh_terms: D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D011446:Prospective Studies; D011856:Radiographic Image Enhancement / Q000379:methods*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000000981:diagnostic imaging*; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*