Transformation of jervine by Cunninghamella elegans ATCC 9245.
Preparative-scale fermentation of the known C-nor-D-homosteroidal jerveratrum alkaloid jervine with Cunninghamella elegans (ATCC 9245) has resulted in the isolation of (-)-jervinone as the major metabolite. In addition, C. elegans ATCC 9245 was able to epimerize C-3 of jervine, producing 3-epi-jervine. This epimerization reaction was similar to that reported for tomatidine, the known spirosolane-type Solanum alkaloid. The structure elucidation of both metabolites was based primarily on 1D- and 2D-NMR analyses.
El Sayed
K A
KA
Faculty of Pharmacy, Pharmacognosy Department, Mansoura University, Egypt. elsayed99@yahoo.com
Halim
A F
AF
Zaghloul
A M
AM
Dunbar
D C
DC
McChesney
J D
JD
D005285:Fermentation; D009090:Mucorales / Q000378:metabolism*; D013057:Spectrum Analysis; D014704:Veratrum Alkaloids / Q000378:metabolism*
D014704:Veratrum Alkaloids; C010206:jervine