title: [Biologically active fragment of the differentiation factor from HL-60 cell line. Identification and properties].
abstract: Six-membered peptide fragment TGENHR (HLDF-6) was identified in the HL-60 cell culture of human promyelocyte leukemia treated with retinoic acid when studying the differentiation factor HLDF of this cell line. HLDF-6 retains the ability of the full-size factor to induce the differentiation and arrest the proliferation of the starting HL-60 cells. It was shown that the synthetic peptide HLDF-6 has no specific receptors on the surface of the HL-60 cells but can affect the binding of interleukin IL-1 beta, a cytokine involved in proliferation, to the cell surface. It was found on a model of transplantable NSO myeloma that HLDF-6 has an antitumor activity.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow, Russia. kost@ibch.ru
authors.forename: I A
authors.initials: IA
authors.lastname: Kostanian
authors.forename: M V
authors.initials: MV
authors.lastname: Astapova
authors.forename: E V
authors.initials: EV
authors.lastname: Navolotskaia
authors.forename: T N
authors.initials: TN
authors.lastname: Lepikhova
authors.forename: S M
authors.initials: SM
authors.lastname: Dranitsyna
authors.forename: G B
authors.initials: GB
authors.lastname: Telegin
authors.forename: I L
authors.initials: IL
authors.lastname: Rodionov
authors.forename: L K
authors.initials: LK
authors.lastname: Baĭdakova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Zolotarev
authors.forename: I M
authors.initials: IM
authors.lastname: Molotkovskaia
authors.forename: V M
authors.initials: VM
authors.lastname: Lipkin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D016898:Interferon-alpha / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009363:Neoplasm Proteins / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D011994:Recombinant Proteins / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha; D007375:Interleukin-1; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C091149:cell differentiation factor 8.2-kDa