Subacute cutaneous lupus erythematosus: report of a patient who subsequently developed a meningioma and whose skin lesions were treated with isotretinoin.
Cancer has been reported in patients with systemic lupus erythematosus (SLE). A possible association of the development of hematologic malignancies in patients with SLE has been suggested. In some patients, subacute cutaneous lupus erythematosus, a distinct subset of lupus erythematosus, has appeared, resolved, or both as a solid tumor-related paraneoplastic syndrome. A woman in whom a meningioma was diagnosed 44 years following the onset of subacute cutaneous lupus erythematosus is described; her skin lesions improved after starting isotretinoin therapy. The relationship between lupus erythematosus and neoplasia is summarized and the management of subacute cutaneous lupus erythematosus with retinoids is reviewed.
Richardson
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TT
Department of Internal Medicine, University of Nevada, Las Vegas, USA.
Cohen
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PR
D000287:Administration, Topical; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002990:Clobetasol / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D005447:Fluocinonide / Q000627:therapeutic use; D005938:Glucocorticoids; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008178:Lupus Erythematosus, Cutaneous / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D008577:Meningeal Neoplasms / Q000209:etiology*; D008579:Meningioma / Q000209:etiology*
D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D005938:Glucocorticoids; D005447:Fluocinonide; D002990:Clobetasol; D015474:Isotretinoin