2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice.
2-Arachidonylglycerol (2-AG) inhibits the production in vitro of tumor necrosis factor-alpha (TNF-alpha) by mouse macrophages, as well as in mice. It has no effect on the production of nitric oxide (NO). The effect on TNF-alpha is enhanced when 2-AG is administered together with 2-linoleylglycerol (2-Lino-G) and 2-palmitylglycerol (2-PalmG), an 'entourage effect' previously noted in several behavioral and binding assays. 2-AG also suppresses the formation of radical oxygen intermediates.
Gallily
R
R
The Lautenberg Center for General and Tumor Immunology, The Hebrew University, Hadassah Medical School, 91120, Jerusalem, Israel.
Breuer
A
A
Mechoulam
R
R
D000818:Animals; D001095:Arachidonic Acids; D002186:Cannabinoids / Q000494:pharmacology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D063388:Endocannabinoids; D005989:Glycerides / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D001095:Arachidonic Acids; D002186:Cannabinoids; D063388:Endocannabinoids; D005989:Glycerides; D014409:Tumor Necrosis Factor-alpha; C114956:2-palmitoylglycerol; C114955:2-linoleoylglycerol; C094503:glyceryl 2-arachidonate