title: Solid-phase synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics.
abstract: A solid-phase method for the synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics has been developed. The key step in the strategy is the Pictet-Spengler condensation of a resin-bound tryptophan-containing fragment with an Fmoc-amino aldehyde.
authors.affiliation: Sphinx Pharmaceuticals, A Division of Eli Lilly and Company, Cambridge, Massachusetts 02139, USA.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: S E
authors.initials: SE
authors.lastname: Hall
authors.forename: J P
authors.initials: JP
authors.lastname: Tam
mesh_terms: D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D014364:Tryptophan / Q000737:chemistry
chemical_list: D002243:Carbolines; D010455:Peptides; C009804:tryptoline; D014364:Tryptophan