title: Inheritance of disc calcification in the dachshund.
abstract: The occurrence of intervertebral disc calcification was investigated by conventional spinal radiography in eight families of wirehaired dachshunds, with each family comprising one sire, two dams and one litter from each dam. Each offspring was examined radiographically once at 24-35 months of age. The occurrence of disc calcification was rated according to four different scales. A strong correlation was found in the occurrence of disc calcification between offspring and mean parent (P < 0.001) and between offspring and dams (P < 0.005) on an either/or scale. Statistically significant estimates of heritability of 0.60 and 0.87 were found based on the offspring-sire relationship using the total score and three-class scale, respectively. Higher correlation estimates were found based on the dam-offspring relationship than based on the sire-offspring relationship, suggesting an effect of maternal environmental factors.
authors.affiliation: Department of Clinical Studies, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: V F
authors.initials: VF
authors.lastname: Jensen
authors.forename: K A
authors.initials: KA
authors.lastname: Christensen
mesh_terms: D000818:Animals; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D007405:Intervertebral Disc Displacement / Q000000981:diagnostic imaging / Q000235:genetics / Q000662:veterinary*; D016014:Linear Models; D008297:Male; D011859:Radiography; D012044:Regression Analysis; D013131:Spine / Q000000981:diagnostic imaging