title: Preventive efficacy of clinoptilolite in broilers during chronic aflatoxin (50 and 100 ppb) exposure.
abstract: This study was conducted to evaluate the protective efficacy of clinoptilolite (CLI, a natural zeolite) in the prevention of toxic effects of aflatoxin (AF). A total of 576 1-day-old Ross broiler chicks were housed in six treatment groups [six replicates of 16 each; control, CLI (15 g kg(-1)diet), 50 parts per billion (ppb) AF, 50 ppb AF plus CLI, 100 ppb AF, 100 ppb AF plus CLI ] for 42 days. Compared to controls, 100 ppb AF treatment significantly decreased body weight gains of chicks. The addition of CLI to the 100 ppb AF - containing diet moderately reduced the adverse effects of AF on performances of chicks. The chicks consuming 50 ppb AF -containing diet showed no significant differences on investigated parameters compared to controls. Also, the single addition of CLI to the AF -free diet had no adverse effects in birds. These results suggest that CLI can be beneficial in broilers for protection of AF toxicity at the level above.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selçuk, Kampüs, Konya, 42031, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Oğuz
authors.forename: V
authors.initials: V
authors.lastname: Kurtoğlu
authors.forename: B
authors.initials: B
authors.lastname: Coşkun
mesh_terms: D000348:Aflatoxins / Q000008:administration & dosage / Q000633:toxicity*; D000821:Animal Feed; D000818:Animals; D001230:Aspergillus; D002645:Chickens; D005260:Female; D008297:Male; D015651:Mycotoxicosis / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000517:prevention & control*; D017641:Zeolites / Q000627:therapeutic use*
chemical_list: D000348:Aflatoxins; C083175:clinoptilolite; D017641:Zeolites