title: Selective contrast-enhanced MR angiography.
abstract: In this study the feasibility of intraarterial contrast administration was investigated. Its use for navigation and treatment evaluation during MR-guided intravascular interventions was explored in phantom and animal experiments. An injection protocol was developed, which accounts for sequence parameters and vessel flow rate. Tracking a bolus of contrast agent was useful to verify the catheter tip position and to assess flow conditions. Compared to intravenous contrast-enhanced magnetic resonance angiography (CE-MRA), selective contrast administration permitted a strongly reduced dose. In two-dimensional (2D) acquisitions overlap of vessels was prevented. Injection and acquisition were easily and accurately synchronized in selective 3D CE-MRA, and a high contrast concentration could be maintained during the entire acquisition. Selective injection is useful in the course of an intervention, to facilitate navigation, provide information on flow conditions, and to evaluate treatment progress repeatedly.
authors.affiliation: Department of Radiology, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. clemens@isi.uu.nl
authors.forename: C
authors.initials: C
authors.lastname: Bos
authors.forename: H F
authors.initials: HF
authors.lastname: Smits
authors.forename: C J
authors.initials: CJ
authors.lastname: Bakker
authors.forename: M A
authors.initials: MA
authors.lastname: Viergever
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D005240:Feasibility Studies; D019786:Gadolinium DTPA / Q000008:administration & dosage; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D019047:Phantoms, Imaging; D011673:Pulsatile Flow; D013552:Swine
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA