Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains.
AT-rich element binding factor 1 (ATBF1) mRNA encodes a transcription factor implicated in neuronal differentiation. A cDNA for the protein that can bind the 5'-noncoding sequence of the ATBF1 mRNA was cloned. The deduced protein, termed SRL300, contains a unique RNA-binding region, two large RS domains and many phosphorylation sites. SRL300 protein was detected in both human and rat cells.
Sawada
Y
Y
Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, Central Ward, Sapporo, Japan. ysawada@sapmed.ac.jp
Miura
Y
Y
Umeki
K
K
Tamaoki
T
T
Fujinaga
K
K
Ohtaki
S
S
D000595:Amino Acid Sequence; D000818:Animals; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000032:analysis; D006367:HeLa Cells; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D051381:Rats
D018076:DNA, Complementary; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C414618:SRRM2 protein, human; C489512:Zfhx3 protein, rat; C071660:ZFHX3 protein, human