Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.
In order to clarify the relationship of the cyclooxygenase-2 immunoreactivity and the progression of depressed-type colorectal adenomas and cancers, we examined cyclooxygenase-2 expression in depressed-type colorectal adenomas and cancers. Immunohistochemical staining was performed by the streptavidin-biotin method. Among 100 adenomas, depressed-type were found in 15, cyclooxygenase-2 expression was not detected in depressed-types, and lesion size in depressed-types did not differ from that in others. Among 100 submucosal invasive cancers, depressed-type were found in 14, cyclooxygenase-2 expression was not detected in depressed-types, and lesion size in tumor with depressed-type did not differ from that in others. Among 100 cancers invading the muscularis propria, depressed-types in 15, cyclooxygenase-2 expression was not detected in depressed-types; these were significantly smaller lesions than those in others (p<0.05). Our results suggest that depressed-type cancers do not result from cyclooxygenase-2 expression.
Saito
K
K
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi-shi, Gunma 371-8511, Japan. k-saito@mail.wind.co.jp
Arai
K
K
Mori
M
M
D000236:Adenoma / Q000201:enzymology* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D051546:Cyclooxygenase 2; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000276:immunology / Q000378:metabolism*; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000276:immunology / Q000378:metabolism*
D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases