title: Cytosolic calcium alterations in platelets of patients with early stages of Alzheimer's disease.
abstract: Alterations in calcium homeostasis might be implicated in the neuropathology of Alzheimer's disease (AD). To date it is not clear whether changes in cytosolic calcium level ([Ca2+ ]i) are the result or the cause of pathogenic effects. In platelets of patients with early stages of AD, the basal values of [Ca2+]i in the absence of extracellular Ca2+ were significantly lower in comparison with age-matched and young controls. After the addition of 1 mM calcium into the incubation medium the [Ca2+]i markedly increased in platelets of AD patients whereas the increase only to a smaller extent was observed in control age-matched and young subjects. The present study proposes that calcium dysregulation during the whole disease period could not be uniform and according to our results the [Ca2+]i is reduced in the first stages of AD. We suggest that the disturbed calcium homeostasis in AD is an "early defect."
authors.affiliation: Laboratory of Biochemistry, Prague Psychiatric Center, Prague, Czech Republic. ripova@pcp.lF3.cuni.cz
authors.forename: D
authors.initials: D
authors.lastname: Rípovi
authors.forename: V
authors.initials: V
authors.lastname: Platilová
authors.forename: A
authors.initials: A
authors.lastname: Strunecká
authors.forename: R
authors.initials: R
authors.lastname: Jirák
authors.forename: C
authors.initials: C
authors.lastname: Höschl
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000814:Aniline Compounds; D001792:Blood Platelets / Q000378:metabolism*; D002118:Calcium / Q000493:pharmacokinetics*; D003600:Cytosol / Q000378:metabolism; D005260:Female; D005456:Fluorescent Dyes; D006706:Homeostasis; D006801:Humans; D008297:Male; D014966:Xanthenes
chemical_list: D000814:Aniline Compounds; D005456:Fluorescent Dyes; D014966:Xanthenes; C059715:Fluo-3; D002118:Calcium