title: Von Willebrand's disease in the German shepherd dog.
abstract: Two litters of German shepherd dogs were evaluated for a haemorrhagic tendency that was characterised by excessive bleeding from the umbilicus at birth, haemorrhage and haematoma formation at vaccination, excessive bruising, and lameness due to haemarthrosis. Platelet counts, clotting times and Von Willebrand's factor (VWF) assays were assessed in all dogs. Factor VIII determination was performed in 1 puppy and its parents. Based on the clotting times and VWF assay, 6 puppies (4 male and 2 female) showed type I Von Willebrand's disease (VWD), 5 (4 male and 1 female) possible type II VWD, and 4 were unaffected. One puppy with possible type II VWD had very low factor VIII activity; its sire had a normal factor activity, whereas the dam was in the low-normal range. This article reports type I and possible type II VWD in 2 related litters of German shepherd dogs, the latter being rare in German shepherd dogs.
authors.affiliation: Department of Companion Animal Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
authors.forename: R G
authors.initials: RG
authors.lastname: Lobetti
authors.forename: T
authors.initials: T
authors.lastname: Dippenaar
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics; D004285:Dogs; D005260:Female; D005838:Genotype; D006470:Hemorrhage / Q000662:veterinary*; D006487:Hemostasis; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D010375:Pedigree; D011517:Prothrombin Time / Q000662:veterinary; D014842:von Willebrand Diseases / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D014841:von Willebrand Factor / Q000032:analysis / Q000276:immunology*
chemical_list: D014841:von Willebrand Factor