title: Ion-pair formation as a strategy to enhance topical delivery of salicylic acid.
abstract: An in-vitro study was carried out to determine the possibility of improving the efficiency of transdermal delivery of salicylate through human epidermis by ion-pair formers (alkylamines and quaternary ammonium ions). Further, the relationship between the physicochemical properties of the counter-ions and salicylate flux was examined. It was found that flux can be related to the conductivity associated with the penetrant solution, molecular size of the counter-ion and lipophilicity expressed as either octanol/water partition coefficient of the ion pairs or the carbon chain-length of the counter-ions. Equations have been developed to predict salicylate flux from these physicochemical parameters.
authors.affiliation: Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, Australia.
authors.forename: S A
authors.initials: SA
authors.lastname: Megwa
authors.forename: S E
authors.initials: SE
authors.lastname: Cross
authors.forename: H A
authors.initials: HA
authors.lastname: Benson
authors.forename: M S
authors.initials: MS
authors.lastname: Roberts
mesh_terms: D000279:Administration, Cutaneous; D000588:Amines / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002463:Cell Membrane Permeability / Q000187:drug effects; D005260:Female; D006801:Humans; D007474:Ion Exchange; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D020156:Salicylic Acid / Q000008:administration & dosage*; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D000588:Amines; D000890:Anti-Infective Agents; D000644:Quaternary Ammonium Compounds; D020156:Salicylic Acid