CD5+ immunophenotype in the bone marrow but not in the peripheral blood in a patient with hairy cell leukemia.
We report the case of a patient with rare CD5+ hairy cell leukemia, which was unusual, as there was also a discrepancy between the bone marrow and peripheral blood immunophenotypes. We propose that some degree of maturation within the malignant clone and the predominance of more mature CD5- hairy cells in the peripheral blood can explain this observation. The patient was treated with a conventional course of cladribine (2'-chlorodeoxyadenosine) and achieved complete remission. We conclude that the unusual CD5+ immunophenotype of this patient did not affect prognosis or change the response to standard therapy.
Usha
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L
Section of Hematology-Oncology, University of Illinois at Chicago, 60607-7173, USA. ushalyd@uic.edu
Bradlow
B
B
Stock
W
W
Platanias
L C
LC
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology*; D018956:CD5 Antigens / Q000097:blood; D017338:Cladribine / Q000008:administration & dosage; D002999:Clone Cells / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000276:immunology* / Q000473:pathology; D008297:Male; D012074:Remission Induction
D018956:CD5 Antigens; D017338:Cladribine