title: Neutral taxoids from Taxus cuspidata as modulators of multidrug-resistant tumor cells.
abstract: Two taxoids, taxinine NN-7 (1) and 3,11-cyclotaxinine NN-2 (2), were isolated from the neutral fraction of the EtOAc extract of a mixture of needles and young stems of Taxus cuspidata. The structures were determined by spectroscopic analysis. Both compounds showed some activity as modulators of multidrug-resistant tumor cells.
authors.affiliation: Graduate School of Science and Technology, Niigata University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kosugi
authors.forename: J
authors.initials: J
authors.lastname: Sakai
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Hagiwara
authors.forename: N
authors.initials: N
authors.lastname: Hirata
authors.forename: K
authors.initials: K
authors.lastname: Hirose
authors.forename: M
authors.initials: M
authors.lastname: Ando
authors.forename: A
authors.initials: A
authors.lastname: Tomida
authors.forename: T
authors.initials: T
authors.lastname: Tsuruo
mesh_terms: D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D017239:Paclitaxel / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D043823:Taxoids; D014197:Trees / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: C419071:3,11-cyclotaxinine NN-2; D004224:Diterpenes; D043823:Taxoids; C419070:taxinine NN-7; D017239:Paclitaxel