Effect of methylene blue on the disposition of ethanol.
The effect of methylene blue on the disposition of ethanol was studied in rats and humans. Methylene blue increased the metabolism of [(14)C]ethanol to (14)CO(2) in isolated hepatocytes and in intact rats by 75% and 30%, respectively. In healthy volunteers, methylene blue did not affect the pharmacokinetics of ethanol and did not alleviate the ethanol-induced NAD redox changes as reflected by the increase in the [lactate]/[pyruvate] ratio.
Vonlanthen
R
R
Department of Medicine, Kantonsspital Baden, Bern, Switzerland.
Beer
J H
JH
Lauterburg
B H
BH
D000328:Adult; D000818:Animals; D002492:Central Nervous System Depressants / Q000097:blood / Q000493:pharmacokinetics*; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics*; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D022781:Hepatocytes / Q000378:metabolism*; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D008751:Methylene Blue / Q000493:pharmacokinetics*; D019289:Pyruvic Acid / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D002492:Central Nervous System Depressants; D004791:Enzyme Inhibitors; D019344:Lactic Acid; D000431:Ethanol; D019289:Pyruvic Acid; D008751:Methylene Blue