Nausea and vomiting in pregnancy: an association between symptoms and maternal prostaglandin E2.
This study investigated the aetiology of nausea and vomiting in pregnancy (NVP) in primary care using a new methodology. Eighteen women in early pregnancy had 2 blood samples taken in one 24-hour time period, one when they were symptomatic, and another when they were symptom-free. Maternal serum levels of the candidate agents PGE2, IL-1beta, and TNFalpha were measured. The study shows a positive relationship between NVP and maternal serum PGE2 levels in early pregnancy.
Gadsby
R
R
GP Nuneaton and Warwick University, Coventry, UK. R.Gadsby@warwick.ac.uk
Barnie-Adshead
A
A
Grammatoppoulos
D
D
Gadsby
P
P
D000293:Adolescent; D000328:Adult; D015232:Dinoprostone / Q000097:blood*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D009325:Nausea / Q000097:blood / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014839:Vomiting / Q000097:blood / Q000209:etiology*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D015232:Dinoprostone