title: PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate.
abstract: The article highlighted in this issue is "Peroxisome Proliferator-Activated Receptor Alpha-Null Mice Lack Resistance to Acetaminophen Hepatotoxicity Following Clofibrate Exposure" by Chuan Chen, Gayle E. Hennig, Herbert E. Whiteley, J Christopher Corton, and José E. Manautou (pp. 338-344).
authors.affiliation: Department of Toxicology, College of Pharmacy, The University of Louisiana at Monroe, 700 University Avenue, Monroe, Louisiana 71209, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Mehendale
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000517:prevention & control*; D002994:Clofibrate / Q000494:pharmacology*; D004351:Drug Resistance; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D020025:Peroxisome Proliferators / Q000378:metabolism*; D020675:Peroxisomes / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D000960:Hypolipidemic Agents; D020025:Peroxisome Proliferators; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000082:Acetaminophen; D002994:Clofibrate