[Persisting viral infection, serum antibodies and chromosome instability in myasthenia].
There were examined 94 patients, aged from 22 to 68 years, with myasthenia, in whom morphological changes of thymic gland were revealed. In 89% of observations there was established the infectioning by cytomegalovirus, in 10%--hepatitis B, in 9%--hepatitis C. In 5% of patients there were observed coexistence of cytomegaloviral infection and hepatitis. In all the patients the trustworthy increase of the chromosomal aberrations frequency in comparison with spontaneous level of mutation was revealed. High diagnostic validity of chain reaction with polymerase in the viruses persistence determination was noted. The results of investigation of serous immunoglobulins to the virus neutralizing antibodies ratio may be applied for the indications elaboration in the lymphosorption and immunocorrection application in patients with myasthenia more than 4 years in course.
Klimova
E M
EM
Boĭko
V V
VV
Krivoruchko
I A
IA
Drozdova
L A
LA
Rimarenko
E V
EV
Agarkova
A N
AN
Andreeshchev
S A
SA
D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000276:immunology; D002869:Chromosome Aberrations / Q000235:genetics*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000235:genetics*
D000914:Antibodies, Viral; D007074:Immunoglobulin G