title: Computational fluid dynamic studies of leukocyte adhesion effects on non-Newtonian blood flow through microvessels.
abstract: The study of the effect of leukocyte adhesion on blood flow in small vessels is of primary interest to understand the resistance changes in venular microcirculation. Available computational fluid dynamic studies provide information on the effect of leukocyte adhesion when blood is considered as a homogeneous Newtonian fluid. In the present work we aim to understand the effect of leukocyte adhesion on the non-Newtonian Casson fluid flow of blood in small venules; the Casson model represents the effect of red blood cell aggregation. In our model the blood vessel is considered as a circular cylinder and the leukocyte is considered as a truncated spherical protrusion in the inner side of the blood vessel. The cases of single leukocyte adhesion and leukocyte pairs in positions aligned along the same side, and opposite sides of the vessel wall are considered. The Casson fluid parameters are chosen for cat blood and human blood and comparisons are made for the effects of leukocyte adhesion in both species. Numerical simulations demonstrated that for a Casson fluid with hematocrit of 0.4 and flow rate Q = 0.072 nl/s, a single leukocyte increases flow resistance by 5% in a 32 microns diameter and 100 microns long vessel. For a smaller vessel of 18 microns, the flow resistance increases by 15%.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. bdas@bme.jhu.edu
authors.forename: B
authors.initials: B
authors.lastname: Das
authors.forename: P C
authors.initials: PC
authors.lastname: Johnson
authors.forename: A S
authors.initials: AS
authors.lastname: Popel
mesh_terms: D000818:Animals; D002415:Cats; D002448:Cell Adhesion / Q000502:physiology; D019295:Computational Biology; D006400:Hematocrit; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008833:Microcirculation / Q000502:physiology; D008954:Models, Biological; D012039:Regional Blood Flow / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology