Changes in plasma adenosine concentrations during normal pregnancy.
The aim of this study was to measure changes in plasma adenosine concentration [ADO] during a normal pregnancy and to evaluate the possible role of platelets and red blood cells (RBC) as causes of changes in plasma [ADO]. We measured the plasma [ADO] in normal pregnant women (n = 11) during the first, second and third trimesters. The mean plasma [ADO] in the third trimester was 0.41 +/- 0.08 microM (means +/- SEM), significantly higher than in the first and second trimesters (p < 0.05). In pregnant women, platelet and RBC counts, hematocrit and hemoglobin concentration decreased slightly throughout the pregnancy. The elevation in the plasma [ADO] correlated inversely with the platelet count (r = -0.43, p < 0.05). These results suggest that an increase in the plasma [ADO] in the third trimester may be attributed to the enhanced adenosine release from activated platelets.
Yoneyama
Y
Y
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. yoshi-1@nms.ac.jp
Suzuki
S
S
Sawa
R
R
Takeuchi
T
T
Kobayashi
H
H
Takei
R
R
Kiyokawa
Y
Y
Otsubo
Y
Y
Hayashi
Z
Z
Araki
T
T
D000241:Adenosine / Q000097:blood*; D000328:Adult; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D010976:Platelet Count; D011247:Pregnancy / Q000097:blood*; D011264:Pregnancy Trimesters / Q000097:blood*
D006454:Hemoglobins; D000241:Adenosine