title: Prevalence of the sleep apnea syndrome in acromegaly population.
abstract: The prevalence of sleep apnea syndrome (SAS) in acromegaly is high. Consequences of SAS are serious and are associated with increased morbidity and mortality. The aim of this study was to assess the relative frequency and predictive factors for SAS in a group of patients with acromegaly (n=55). The presence of SAS was evaluated using the Polymesam device. Hormonal and clinical examination consisted of assessment of growth hormone, insulin-like growth factor I plasma levels, body mass index (BMI), neck circumference, age, sex, treatment modes of acromegaly and ear, nose and throat (ENT) examination. The relative frequency of SAS in our group of patients with acromegaly was 75%. Independent predictors of SAS were: increased activity of acromegaly, higher age and neck circumference. No association between SAS and BMI and ENT findings was observed. The role of gender was controversial.
authors.affiliation: 3rd Department of Internal Medicine, 1st Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: V
authors.initials: V
authors.lastname: Weiss
authors.forename: K
authors.initials: K
authors.lastname: Sonka
authors.forename: M
authors.initials: M
authors.lastname: Pretl
authors.forename: S
authors.initials: S
authors.lastname: Dostálová
authors.forename: J
authors.initials: J
authors.lastname: Klozar
authors.forename: P
authors.initials: P
authors.lastname: Rambousek
authors.forename: J
authors.initials: J
authors.lastname: Marek
authors.forename: T
authors.initials: T
authors.lastname: Haas
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000628:therapy; D000328:Adult; D000368:Aged; D000375:Aging; D001699:Biometry; D015992:Body Mass Index; D005260:Female; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009333:Neck; D012727:Sex Characteristics; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I