[Secondary malignant neoplasms in patients with breast cancer].
OBJECTIVE
This report analyzes the occurrence of secondary malignancies among patients with breast cancer.


METHODS
We evaluated all women diagnosed with breast cancer who were reported to the National Cancer Institute of the former GDR in 1976. There was a follow up of 5,485 patients from 1976 to 1988 (38,231 person-years at risk). Cancer incidence rates of the whole female population specific for age and calendar year were used for calculation of the standardized incidence ratio (SIR).


RESULTS
Significantly increased risks were observed for neoplasms of the bilateral breast (SIR 2.44; 95% CI 2.04-2.93), colon (SIR 1.53; 95% CI 1.06-2.12), rectum (SIR 1.65; 95% CI 1.10-2.40), endometrium (SIR 1.55; 95% CI 1.02-2.27), and ovary (SIR 1.71; 95% CI 1.09-2.57). Neoplasms of the lung (SIR 1.65; 95% CI 0.93-2.73), kidney (SIR 1.51; 95% CI 0.69-2.87), bladder (SIR 1.32; 95% CI 0.48-2.87), connective tissue (SIR 3.54; 95% CI 0.73-10.34), and multiple myeloma (SIR 1.98; 95% CI 0.54-5.06) were also increased, not reaching statistical significance. Risk reduction was observed for malignant tumors of the gallbladder (SIR 0.36; 95% CI 0.12-0.83).


CONCLUSIONS
In proposing recommendations for the follow-up and management of women with breast cancer, it is important to recognize their long-term predisposition to an array of secondary cancers.
Dörffel
W V
WV
Schwerpunkt Kardiologie, Angiologie und Pneumologie, Medizinische Klinik und Poliklinik der Charité, Berlin.
Reitzig
P
P
Dörffel
Y
Y
Possinger
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000453:epidemiology; D018572:Disease-Free Survival; D005260:Female; D005833:Genital Neoplasms, Female / Q000453:epidemiology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology; D009372:Neoplasms, Connective Tissue / Q000453:epidemiology; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D011159:Population Surveillance; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies; D012306:Risk; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology