title: Two polyisoprenylated benzophenones from the trunk latex of Clusia grandiflora (Clusiaceae).
abstract: The polyisoprenylated benzophenones, chamones I and II, were isolated from the trunk latex of Clusia grandiflora (Clusiaceae) growing in southeastern Venezuela. A third benzophenone, nemorosone II, was isolated from the pollinator reward resin of the female flowers of the same plant. Chamone I and nemorosone II are structurally similar, differing only in the degree of prenylation. Bioassays of chamone I and nemorosone II using the honeybee pathogens, Paenibacillus larvae and Paenibacillus alvei, demonstrate that both have potent antibacterial activity, and that their structural differences affect both their bactericidal efficacies and their aqueous mobilities.
authors.affiliation: Department of Biology and Wildlife, University of Alaska Fairbanks, 99775, USA. ftjcl@aurora.uaf.edu
authors.forename: J
authors.initials: J
authors.lastname: Lokvam
authors.forename: J F
authors.initials: JF
authors.lastname: Braddock
authors.forename: P B
authors.initials: PB
authors.lastname: Reichardt
authors.forename: T P
authors.initials: TP
authors.lastname: Clausen
mesh_terms: D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification*; D007840:Latex / Q000737:chemistry*; D019685:Rosales / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D001577:Benzophenones; D007840:Latex