title: The dual impact of coxsackie and adenovirus receptor expression on human prostate cancer gene therapy.
abstract: In a recent paper, we reported a significant difference in coxsackie and adenovirus receptor (CAR) from several human bladder cancer cell lines that correlated with their sensitivities to adenoviral infection (Y. Li, R-C. Pong, J. M. Bergelson, M. C. Hall, A. I. Sagalowsky, C-P. Tseng, Z. Wang, and J. T. Hsieh, Cancer Res., 59: 325-330, 1999). In human prostate cancer, CAR protein is down-regulated in the highly tumorigenic PC3 cell line, which suggests that, in addition to its function as a viral receptor, CAR may have a pathophysiological role in prostate cancer progression. In this paper, we document that CAR does not merely enhance the viral sensitivity of prostate cancer cells but also acts as a tumor inhibitor for androgen-independent prostate cancer cells. Our data indicate that CAR is a potential therapeutic agent for increasing the efficacy of prostate cancer therapy.
authors.affiliation: Department of Urology, The University of Texas Southwestern Medical Center, Dallas 75390-9110, USA.
authors.forename: T
authors.initials: T
authors.lastname: Okegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: R C
authors.initials: RC
authors.lastname: Pong
authors.forename: J M
authors.initials: JM
authors.lastname: Bergelson
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: J T
authors.initials: JT
authors.lastname: Hsieh
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D002455:Cell Division / Q000502:physiology; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011991:Receptors, Virus / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D014162:Transfection; D014407:Tumor Cells, Cultured
chemical_list: C568771:CLMP protein, human; C568772:CLMP protein, mouse; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein; D011991:Receptors, Virus