Effect of aerobic and resistance exercise training on vascular function in heart failure.
Exercise training of a muscle group improves local vascular function in subjects with chronic heart failure (CHF). We studied forearm resistance vessel function in 12 patients with CHF in response to an 8-wk exercise program, which specifically excluded forearm exercise, using a crossover design. Forearm blood flow (FBF) was measured using strain-gauge plethysmography. Responses to three dose levels of intra-arterial acetylcholine were significantly augmented after exercise training when analyzed in terms of absolute flows (7.0 +/- 1.8 to 10.9 +/- 2.1 ml x 100 ml(-1) x min(-1) for the highest dose, P < 0.05 by ANOVA), forearm vascular resistance (21.5 +/- 5.0 to 15.3 +/- 3.9 ml x 100 ml forearm(-1) x min(-1), P < 0.01), or FBF ratios (P < 0.01, ANOVA). FBF ratio responses to sodium nitroprusside were also significantly increased after training (P < 0.05, ANOVA). Reactive hyperemic flow significantly increased in both upper limbs after training (27.9 +/- 2.7 to 33.5 +/- 3.1 ml x 100 ml(-1) x min(-1), infused limb; P < 0.05 by paired t-test). Exercise training improves endothelium-dependent and -independent vascular function and peak vasodilator capacity in patients with CHF. These effects on the vasculature are generalized, as they were evident in a vascular bed not directly involved in the exercise stimulus.
Maiorana
A
A
Department of Human Movement and Exercise Science, The University of Western Australia, Nedlands 6907.
O'Driscoll
G
G
Dembo
L
L
Cheetham
C
C
Goodman
C
C
Taylor
R
R
Green
D
D
D000109:Acetylcholine / Q000494:pharmacology; D001808:Blood Vessels / Q000503:physiopathology*; D002303:Cardiac Output, Low / Q000503:physiopathology*; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D015444:Exercise / Q000502:physiology*; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000494:pharmacology; D010806:Physical Education and Training; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014665:Vasodilator Agents / Q000494:pharmacology; D014891:Weight Lifting / Q000502:physiology*
D014665:Vasodilator Agents; D009599:Nitroprusside; D000109:Acetylcholine