title: Pain after epithelial removal by ethanol-assisted mechanical versus transepithelial excimer laser debridement.
abstract: OBJECTIVE
  To compare subjective pain responses between two techniques of epithelial removal prior to photorefractive keratectomy (PRK) treatment: ethanol-soaked pledget with mechanical debridement of the epithelium versus excimer laser transepithelial ablation.
  
  
  METHODS
  Nine patients underwent bilateral PRK. Each had the epithelium in one eye debrided by placing a pledget soaked in 20% ethanol on the cornea for 2 minutes followed by gentle scraping with a blade. The epithelium in the other eye was removed by transepithelial phototherapeutic keratectomy (PTK) treatment. For each eye, PRK was initiated immediately after removal of the epithelium. On postoperative day one, each patient was asked to rate the level of pain suffered over the last 24 hours on a scale of 0 (minimal) to 10 (maximal). Data were analyzed in a masked fashion.
  
  
  RESULTS
  Postoperative day one average pain level in the ethanol-assisted mechanically debrided eyes was 3.0 +/- 2.5 and in the transepithelial PTK eyes was 6.8 +/- 1.8. The difference was statistically significant by Student's t-test (P < .01). All epithelial defects healed within 3 days with no clinically significant difference in healing time between the two techniques.
  
  
  CONCLUSIONS
  In preparation for PRK, ethanol-assisted mechanical debridement of the epithelium caused significantly less postoperative pain than epithelial removal using the excimer laser.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232-8808, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Kanitkar
authors.forename: J
authors.initials: J
authors.lastname: Camp
authors.forename: H
authors.initials: H
authors.lastname: Humble
authors.forename: D J
authors.initials: DJ
authors.lastname: Shen
authors.forename: M X
authors.initials: MX
authors.lastname: Wang
mesh_terms: D000328:Adult; D003646:Debridement / Q000379:methods*; D019573:Epithelium, Corneal / Q000187:drug effects / Q000601:surgery*; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D054018:Lasers, Excimer; D009216:Myopia / Q000601:surgery; D010146:Pain / Q000517:prevention & control; D010147:Pain Measurement; D018903:Photorefractive Keratectomy; D011446:Prospective Studies; D014945:Wound Healing
chemical_list: D000431:Ethanol