title: The minimum inhibitory concentration of oral antibacterial agents against cariogenic organisms.
abstract: The minimum inhibitory concentrations (MIC) of eight common dental antibacterial agents against three genera of bacteria which have been implicated in dentine caries, namely streptococci, lactobacilli and actinomycetes were investigated. The ultimate aim was to determine the most appropriate antibacterial agent which could be added to dental restorative materials for filling cavities where there was residual dentine caries. The antibacterial agents tested were chlorhexidine diacetate, chlorhexidine dihydrochloride, chlorhexidine gluconate, benzalkonium chloride, cetrimide, cetylpyridinium chloride, thymol and sodium hypochlorite. Thymol and sodium hypochlorite did not inhibit microbial growth at any of the concentrations tested. For the active antibacterial agents tested the MIC values against lactobacilli and streptococci were 0.25 microg/ml to 8.0 microg/ml and for actinomycetes 0.125 to 8.0 microg/ml. These results illustrate the wide spectrum of sensitivity of caries associated bacteria against dental antibacterial agents. From the MIC values alone, it is difficult to recommend which of the active antibacterial agents would be most effective in eliminating cariogenic organisms.
authors.affiliation: Discipline of Oral Rehabilitation, The Prince Philip Dental Hospital, Hong Kong, SAR, China.
authors.forename: M G
authors.initials: MG
authors.lastname: Botelho
mesh_terms: D000192:Actinomycetales / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology; D002593:Cetrimonium Compounds / Q000494:pharmacology; D002594:Cetylpyridinium / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D003731:Dental Caries / Q000382:microbiology*; D004202:Disinfectants / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007778:Lactobacillus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012973:Sodium Hypochlorite / Q000494:pharmacology; D013291:Streptococcus / Q000187:drug effects; D013943:Thymol / Q000494:pharmacology
chemical_list: D000891:Anti-Infective Agents, Local; D001548:Benzalkonium Compounds; D002593:Cetrimonium Compounds; D004202:Disinfectants; D013943:Thymol; D002594:Cetylpyridinium; D012973:Sodium Hypochlorite; D002710:Chlorhexidine