title: Choose your target.
abstract: The technology of modifying endogenous genes has recently been extended from mice to Drosophila and sheep. Concurrently, genomic sequencing is uncovering thousands of previously uncharacterized genes. Armed with today's technologies, what are our best options for delineating the functions of these new genes?
authors.affiliation: Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, USA. mario.capecchi@genetics.utah.edu
authors.forename: M R
authors.initials: MR
authors.lastname: Capecchi
mesh_terms: D000818:Animals; D019976:Cloning, Organism / Q000379:methods; D004331:Drosophila melanogaster / Q000235:genetics; D023281:Genomics / Q000379:methods* / Q000639:trends; D051379:Mice / Q000235:genetics; D012756:Sheep / Q000235:genetics