title: Microchip technology in drug delivery.
abstract: The realization that the therapeutic efficacy of certain drugs can be affected dramatically by the way in which they are delivered has created immense interest in controlled drug delivery systems. Much previous work in drug delivery focused on achieving sustained drug release rates over time, while a more recent trend is to make devices that allow the release rate to be varied over time. Advances in microfabrication technology have made an entirely new type of drug delivery device possible. Proof-of-principle experiments have shown that silicon microchips have the ability to store and release multiple chemicals on demand. Future integration of active control electronics, such as microprocessors, remote control units, or biosensors, could lead to the development of a 'pharmacy on a chip,' ie 'smart' microchip implants or tablets that release drugs into the body automatically when needed.
authors.forename: J T
authors.initials: JT
authors.lastname: Santini
authors.forename: A C
authors.initials: AC
authors.lastname: Richards
authors.forename: R A
authors.initials: RA
authors.lastname: Scheidt
authors.forename: M J
authors.initials: MJ
authors.lastname: Cima
authors.forename: R S
authors.initials: RS
authors.lastname: Langer
mesh_terms: D001698:Biomedical Engineering; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004343:Drug Implants; D006801:Humans; D008904:Miniaturization; D012825:Silicon; D013607:Tablets; D013678:Technology, Pharmaceutical
chemical_list: D003692:Delayed-Action Preparations; D004343:Drug Implants; D013607:Tablets; D012825:Silicon