title: Ribonuclease P: a ribonucleoprotein enzyme.
abstract: The ribonucleoprotein ribonuclease P catalyzes the hydrolysis of a specific phosphodiester bond in precursor tRNA to form the mature 5' end of tRNA. Recent studies have shed light on the structures of RNase-P-RNA-P-protein and RNase-P-RNA-precursor-tRNA complexes, as well as on the positions of catalytic metal ions, emphasizing the importance of the structure to the catalytic function.
authors.affiliation: Department of Chemistry, University of Michigan, 930 North University, Ann Arbor, MI 27710, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Kurz
authors.forename: C A
authors.initials: CA
authors.lastname: Fierke
mesh_terms: D001483:Base Sequence; D002384:Catalysis; D004722:Endoribonucleases / Q000737:chemistry / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D016337:RNA, Catalytic / Q000737:chemistry / Q000378:metabolism*; D012349:RNA, Transfer, Asp / Q000737:chemistry / Q000378:metabolism; D043262:Ribonuclease P; D013379:Substrate Specificity
chemical_list: D016337:RNA, Catalytic; D012349:RNA, Transfer, Asp; D004722:Endoribonucleases; D043262:Ribonuclease P