Interleukin-1beta reduces temperature sensitivity but elevates thermal thresholds in different populations of warm-sensitive hypothalamic neurons in rat brain slices.
Extracellularly recorded firing rates of neurons in slices of the preoptic area and anterior hypothalamus (PO/AH) of the rat were determined during thermal stimulation. Human recombinant interleukin-1beta (20 ng/ml) did not influence temperature-insensitive neurons, but reduced the firing rate and thermosensitivity in linear warm-sensitive neurons, and shifted the thermal thresholds of activation in threshold warm- and cold-sensitive neurons by 1.1-2.3 degrees C to hyperthermic temperatures. The data support the suggestion that endogenous pyrogens may act on different populations of thermosensitive PO/AH neurons to induce fever. The shift of the thermal thresholds of activation of threshold warm- and cold-sensitive neurons in combination with the otherwise maintained temperature sensitivity of these neurons appears to play a major part for the controlled shift of body temperature and the maintenance of the elevated body temperature during cytokine-induced fever.
Vasilenko
V Y
VY
Institute of Physiology, National Academy of Sciences, Skorina Strasse 28, 220072, Minsk, Belarus.
Petruchuk
T A
TA
Gourine
V N
VN
Pierau
F K
FK
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D003080:Cold Temperature; D005334:Fever / Q000209:etiology / Q000378:metabolism*; D006358:Hot Temperature; D007032:Hypothalamus, Anterior / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011301:Preoptic Area / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology
D007375:Interleukin-1