The zebrafish scyba gene encodes a novel CXC-type chemokine with distinctive expression patterns in the vestibulo-acoustic system during embryogenesis.
Chemokines, in addition to their characterized functions as immune modulators, also play a role in developmental processes such as neural cell migration. Although, chemokines have been described in human, mouse and other vertebrate species, they have yet to be characterized in zebrafish. In this paper, we report the isolation and expression analysis of scyba, a zebrafish gene encoding a CXC-type chemokine protein. During early segmentation, scyba transcripts are detected in the midbrain region and the otic placodes. At later developmental stages, scyba expression is restricted to a subset of hindbrain commissural neurons and to the hair-cell sensory patches of the otic vesicle and lateral-line neuromasts.
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Loeb Health Research Institute at the Ottawa Hospital, 725 Parkdale Avenue, ON., K1Y 4E9, Ottawa, Canada.
Quint
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Lin
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Ekker
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000196:embryology; D019556:COS Cells; D019743:Chemokines, CXC / Q000235:genetics*; D018076:DNA, Complementary; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D015027:Zebrafish; D029961:Zebrafish Proteins
D019743:Chemokines, CXC; D018076:DNA, Complementary; D029961:Zebrafish Proteins; C418488:cxcl14 protein, zebrafish