Anti-interleukin-3 and anti-nerve growth factor increase neonatal mice survival to reovirus type 3 clone 9 per oral challenge.
Reovirus type 3 clone 9 (T3C9) induces lethal encephalitis in neonatal, but not adult mice. Whether host factors that promote the development and/or functioning of nervous and gastrointestinal tissues could modulate the pathogenesis of this enteric virus was examined. The results showed that antibody specific for interleukin-3 or nerve growth factor antiserum, but not anti-interleukin-6 or anti-tumor necrosis factor-alpha/beta increased mice survival to T3C9 and decreased viral titers in nervous tissues early after infection. These data suggest that IL-3 and NGF are involved in the pathogenesis of T3C9 infection in neonatal mice.
Derrien
M
M
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. mderrien@pasteur.fr
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D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000494:pharmacology; D002490:Central Nervous System / Q000254:growth & development / Q000276:immunology / Q000821:virology; D018792:Encephalitis, Viral / Q000276:immunology* / Q000401:mortality; D007377:Interleukin-3 / Q000276:immunology*; D015850:Interleukin-6 / Q000276:immunology; D012089:Mammalian orthoreovirus 3 / Q000276:immunology*; D008751:Methylene Blue; D051379:Mice; D020932:Nerve Growth Factor / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology* / Q000401:mortality; D016019:Survival Analysis; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D000906:Antibodies; D007377:Interleukin-3; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D020932:Nerve Growth Factor; D008751:Methylene Blue