Vancomycin resistance is associated with serine-containing peptidoglycan in Enterococcus gallinarum.
In Enterococcus gallinarum SC1, a low-level vancomycin-resistant strain, only monomeric muropentapeptides with a C-terminal D-alanine were detected after growth without vancomycin. In contrast, in SC1 induced by vancomycin, as well as in AIB39, a constitutive vancomycin-resistant strain, monomeric and dimeric muropentapeptides with a C-terminal D-serine were detected.
Grohs
P
P
Laboratoire de Recherche Moléculaire sur les Antibiotiques, UFR Broussais-Hôtel Dieu, Université Paris VI, Paris, France.
Gutmann
L
L
Legrand
R
R
Schoot
B
B
Mainardi
J L
JL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D016983:Enterococcus / Q000737:chemistry / Q000187:drug effects*; D010457:Peptidoglycan / Q000032:analysis* / Q000737:chemistry; D012694:Serine / Q000032:analysis; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D010457:Peptidoglycan; D012694:Serine; D014640:Vancomycin