The divergent role of tumor necrosis factor receptors in infectious diseases.
Tumor necrosis factor (TNF) receptor types 1 and 2 are broadly expressed by most cell types and are activated by binding of either TNF or lymphotoxin-beta. TNF receptor-mediated immune reactions are critically important in the pathogenesis and control of a variety of infections caused by bacteria, viruses, protozoa, and fungi. This review summarizes recent findings on the role of TNF receptors in infectious diseases and discusses the divergent functions of these receptors in immune responses.
Schlüter
D
D
Institut für Med. Mikrobiologie und Hygiene, Universitätsklinikum Mannheim, Universität Heidelberg, Heidelberg, Germany.
Deckert
M
M
D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007239:Infections / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008233:Lymphotoxin-alpha / Q000378:metabolism; D053308:Lymphotoxin-beta; D008565:Membrane Proteins / Q000378:metabolism; D009181:Mycoses / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011528:Protozoan Infections / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology
C505886:LTB protein, human; D008233:Lymphotoxin-alpha; D053308:Lymphotoxin-beta; D008565:Membrane Proteins; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha