Neonatal outcome of preimplantation genetic diagnosis by polar body removal: the first 109 infants.
BACKGROUND
Our center developed the technique of preimplantation genetic diagnosis (PGD) by sequential polar body removal (PBR) for the diagnosis of Mendelian disorders and aneuploidies. This study examines the obstetric and neonatal outcome of the first 109 live births after PGD by PBR.


OBJECTIVE
To determine if there were any observable effects of PGD by PBR on perinatal morbidity and mortality, birth defects, and growth parameters.


METHODS
Data on perinatal outcome were gathered for the first 109 infants by parental reporting and confirmed by telephone interview and chart review when indicated. In infants >6 months old, a follow-up telephone interview was performed establishing the developmental milestones attained by the child.


METHODS
A research center conducting an institutional review board-approved research protocol in PGD.


METHODS
All patients who had PGD by PBR who had clinical pregnancies.


METHODS
Gestational age, mode of delivery, perinatal mortality, birth weight, birth length, the presence of birth defects, and developmental milestones.


RESULTS
There was no significant decrease in birth length or weight, or the frequency of small for gestational age infants. No specific pattern of birth defects was observed.


CONCLUSIONS
Thus far, there are no observable detrimental effects of PGD by PBR on children born after the procedure.
Strom
C M
CM
Reproductive Genetics Institute, Department of Obstetrics and Gynecology, Illinois Masonic Medical Center, Chicago, Illinois 60657, USA. dnaguy@aol.com
Levin
R
R
Strom
S
S
Masciangelo
C
C
Kuliev
A
A
Verlinsky
Y
Y
D000782:Aneuploidy; D001724:Birth Weight; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D000013:Congenital Abnormalities / Q000453:epidemiology; D005260:Female; D005307:Fertilization in Vitro; D030342:Genetic Diseases, Inborn / Q000175:diagnosis; D005820:Genetic Testing / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D009865:Oocytes; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis / Q000009:adverse effects / Q000379:methods*; D020554:Sperm Injections, Intracytoplasmic