Choroidal neovascularization with granulomatous inflammation in ocular histoplasmosis syndrome.
OBJECTIVE
To report pathologic examination of an excised choroidal neovascular membrane in a patient with ocular histoplasmosis syndrome that demonstrated granulomatous inflammation.


METHODS
Case report. A 50-year-old woman with sudden vision loss in her left eye demonstrated clinical and fluorescein angiographic findings characteristic of choroidal neovascularization secondary to ocular histoplasmosis syndrome.


RESULTS
Histopathologic examination of the surgically excised choroidal neovascular membrane disclosed granulomatous inflammation.


CONCLUSIONS
This case suggests an important role of mononuclear phagocytic cells as primary mediators of angiogenesis or modifiers of choroidal neovascularization. This association of choroidal neovascularization with granulomatous inflammation did not respond to treatment with systemic corticosteroids.
Mann
E S
ES
Department of Ophthalmology, Saint Louis University Health Sciences Center, St Louis, Missouri, USA. manne4@slu.edu
Fogarty
S J
SJ
Kincaid
M C
MC
D020256:Choroidal Neovascularization / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D019773:Epiretinal Membrane / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D015821:Eye Infections, Fungal / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006099:Granuloma / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D006660:Histoplasmosis / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D013577:Syndrome; D014792:Visual Acuity