[Role of lysosomes in the intracellular mineral elements: the case of lanthane].
The subcellular localization of lanthane was studied using two microanalytic methods. 1.) The election microprobe method showed that lanthane is concentrated in the lysosomes of the hepatocytes and the spleen associated with phosphorus. 2.) The ion microanalysis showed that lanthane is selectively precipitated in the lysosomes of the enterocytes optical part. This mechanism of selective precipitation initially prevents the diffusion of this toxic element in the organism and then permits its elimination digestively after desquamation of enterocytes in apoptosis in the intestinal lumen.
Manoubi-Tékaya
L
L
Laboratoire de Physiologie, Faculté de Médecine, Creteil, France.
Houcine
N
N
Galle
P
P
D000284:Administration, Oral; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D004577:Electron Probe Microanalysis; D020895:Enterocytes / Q000502:physiology; D007274:Injections, Intraperitoneal; D007413:Intestinal Mucosa / Q000502:physiology*; D007811:Lanthanum / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism*; D008099:Liver / Q000648:ultrastructure*; D008247:Lysosomes / Q000737:chemistry* / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000648:ultrastructure*
D007811:Lanthanum