title: An open trial of plasma exchange in childhood-onset obsessive-compulsive disorder without poststreptococcal exacerbations.
abstract: Patients with childhood-onset obsessive-compulsive disorder (OCD) with symptom exacerbations following streptococcal infections benefit from treatment with plasma exchange. In this study, 5 patients with treatment-refractory OCD without a history of streptococcus-related exacerbations underwent an open 2-week course of therapeutic plasma exchange. Behavioral ratings, completed at baseline and 4 weeks after the initial treatment, included the Clinical Global Impressions Scale and the Yale-Brown Obsessive Compulsive Scale. All 5 patients completed the trial with few side effects, but none showed significant improvement. Plasma exchange does not benefit children and adolescents with OCD who do not have streptococcus-related exacerbations.
authors.affiliation: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA. nicolson@box-n.nih.gov
authors.forename: R
authors.initials: R
authors.lastname: Nicolson
authors.forename: S E
authors.initials: SE
authors.lastname: Swedo
authors.forename: M
authors.initials: M
authors.lastname: Lenane
authors.forename: J
authors.initials: J
authors.lastname: Bedwell
authors.forename: M
authors.initials: M
authors.lastname: Wudarsky
authors.forename: P
authors.initials: P
authors.lastname: Gochman
authors.forename: S D
authors.initials: SD
authors.lastname: Hamburger
authors.forename: J L
authors.initials: JL
authors.lastname: Rapoport
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000628:therapy*; D010951:Plasma Exchange; D013290:Streptococcal Infections / Q000628:therapy*; D016896:Treatment Outcome