title: A novel protein transport system involved in the biogenesis of bacterial electron transfer chains.
abstract: The Tat system is a recently discovered bacterial protein transport pathway that functions primarily in the biosynthesis of proteins containing redox active cofactors. Analogous transport systems are found in plant organelles. Remarkably and uniquely the Tat system functions to transported a diverse range of folded proteins across a biological membrane, a feat that must be achieved without rendering the membrane freely permeable to protons and other ions. Here we review the operation of the bacterial Tat system and propose a model for the structural organisation of the Tat preprotein translocase.
authors.affiliation: Centre for Metalloprotein Spectroscopy and Biology, School of Biological Sciences, University of East Anglia, Norwich, UK. b.berks@uea.ac.uk
authors.forename: B C
authors.initials: BC
authors.lastname: Berks
authors.forename: F
authors.initials: F
authors.lastname: Sargent
authors.forename: E
authors.initials: E
authors.lastname: De Leeuw
authors.forename: A P
authors.initials: AP
authors.lastname: Hinsley
authors.forename: N R
authors.initials: NR
authors.lastname: Stanley
authors.forename: R L
authors.initials: RL
authors.lastname: Jack
authors.forename: G
authors.initials: G
authors.lastname: Buchanan
authors.forename: T
authors.initials: T
authors.lastname: Palmer
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D004579:Electron Transport; D004734:Energy Metabolism; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D005809:Genes, Regulator; D007425:Intracellular Membranes / Q000737:chemistry / Q000378:metabolism; D026901:Membrane Transport Proteins; D021381:Protein Transport; D000069816:SEC Translocation Channels; D000081416:SecA Proteins
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D000069816:SEC Translocation Channels; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins