title: Pathophysiology of calcium and phosphorus disorders.
abstract: Hypocalcemia and hypophosphatemia are relatively common in periparturient cows. This article reviews the etiologic factors that contribute to the development of these conditions. The physiologic role of magnesium in calcium homeostasis and the physiologic effect of dietary cation-anion difference at the cellular level are discussed in depth. A theory to explain the development of periparturient hypophosphatemia is developed.
authors.affiliation: National Animal Disease Center, USDA-Agricultural Research Service, Ames, Iowa, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Goff
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D002418:Cattle Diseases / Q000503:physiopathology* / Q000517:prevention & control; D003612:Dairying; D005260:Female; D006706:Homeostasis; D006996:Hypocalcemia / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary*; D017674:Hypophosphatemia / Q000503:physiopathology / Q000517:prevention & control / Q000662:veterinary*; D007774:Lactation; D010281:Parathyroid Hormone / Q000502:physiology; D010758:Phosphorus / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D010281:Parathyroid Hormone; D010758:Phosphorus; D002118:Calcium