[Immunopharmacological method for the diagnosis of multiple sclerosis].
Using the data on increased level of opioids in the internal media of patients with multiple sclerosis it was found that blood lymphocytes from MS patients had elevated adhesive activity to opiates, including morphine, in the reaction of specific rosette formation. Immunopharmacologic method for MS diagnosis is proposed based on detection of considerably increased level of the rosette forming cells, specific to morphine (morphine test). This test is a reliable additional marker for all clinical forms of the disease and provides differential diagnosis of both MS and some other diseases with similar clinical symptomatology at any age, any duration and a character of a course of the disease.
Shutov
A A
AA
Bykova
A A
AA
Volodina
E V
EV
D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000097:blood / Q000493:pharmacokinetics; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009294:Narcotics / Q000097:blood / Q000493:pharmacokinetics; D012397:Rosette Formation / Q000379:methods*
D009294:Narcotics; D009020:Morphine