Adaptive plasticity in vestibular influences on cardiovascular control.
Data collected in both human subjects and animal models indicate that the vestibular system influences the control of blood pressure. In animals, peripheral vestibular lesions diminish the capacity to rapidly and accurately make cardiovascular adjustments to changes in posture. Thus, one role of vestibulo-cardiovascular influences is to elicit changes in blood distribution in the body so that stable blood pressure is maintained during movement. However, deficits in correcting blood pressure following vestibular lesions diminish over time, and are less severe when non-labyrinthine sensory cues regarding body position in space are provided. These observations show that pathways that mediate vestibulo-sympathetic reflexes can be subject to plastic changes. This review considers the adaptive plasticity in cardiovascular responses elicited by the central vestibular system. Recent data indicate that the posterior cerebellar vermis may play an important role in adaptation of these responses, such that ablation of the posterior vermis impairs recovery of orthostatic tolerance following subsequent vestibular lesions. Furthermore, recent experiments suggest that non-labyrinthine inputs to the central vestibular system may be important in controlling blood pressure during movement, particularly following vestibular dysfunction. A number of sensory inputs appear to be integrated to produce cardiovascular adjustments during changes in posture. Although loss of any one of these inputs does not induce lability in blood pressure, it is likely that maximal blood pressure stability is achieved by the integration of a variety of sensory cues signaling body position in space.
Yates
B J
BJ
Departments of Otolaryngology and Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA. byates@pitt.edu
Holmes
M J
MJ
Jian
B J
BJ
D000344:Afferent Pathways / Q000166:cytology / Q000502:physiology; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000294:innervation*; D002531:Cerebellum / Q000166:cytology / Q000502:physiology; D003714:Denervation / Q000009:adverse effects; D006801:Humans; D008959:Models, Neurological; D009068:Movement / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D011187:Posture / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology; D012399:Rotation / Q000009:adverse effects; D014725:Vestibular Nerve / Q000166:cytology / Q000502:physiology* / Q000601:surgery; D014726:Vestibular Nuclei / Q000166:cytology / Q000502:physiology