[The role of beta-adrenoreceptors in the mechanism of the hemodynamic action and radiation-protective activity of the copolymer of 2-methyl-5-vinylpyridine with 2-methyl-5-vinylpyridinium-N-oxide].
In experiment on anesthetized dogs and cats in was shown that the new water-soluble copolymer initiated depressive reaction characteristic for beta-adrenomimetics. This effect was levelled with the help of non-selective adrenoblockator--propranololum. In experiment on dogs the preliminary treatment with propranololum decreased the therapeutic antiradiation efficiency of the copolymer from 68.4 to 8.3%.
Korovkina
E P
EP
State Research Centre of Russia, Institute of Biophysics, Moscow, Russia.
Mikhaĭlov
P P
PP
Tsorin
I B
IB
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005720:Gamma Rays; D006439:Hemodynamics / Q000187:drug effects* / Q000528:radiation effects; D011145:Polyvinyls / Q000494:pharmacology* / Q000627:therapeutic use; D011433:Propranolol / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000401:mortality; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000528:radiation effects; D012995:Solubility; D013997:Time Factors
C415062:(2-methyl-5-vinylpyridine)-(2-methyl-5-vinylpyridinium oxide) copolymer; D000319:Adrenergic beta-Antagonists; D011145:Polyvinyls; D011726:Pyridinium Compounds; D011837:Radiation-Protective Agents; D011943:Receptors, Adrenergic, beta; D011433:Propranolol