Activity of sympathoadrenal system and myelokaryocyte death during aging in AKR/JY mice.
Accelerated bone marrow cell death and activation of the sympathoadrenal system were observed during aging of highly leukemic 2-7-month-old AKR/JY mice compared to that in (CBA/CaLacxAKR/JY)F1 strain. Close correlation was revealed between activity of the sympathoadrenal system and necrotic and apoptotic forms of cell death. This can promote tumor process, because maximum changes in hemopoietic cells occur during advanced stage of the disease.
Khlusov
I A
IA
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Stavrova
L A
LA
Fomina
T I
TI
Luk'yanova
T A
TA
Dygai
A M
AM
Gol'dberg
E D
ED
D000313:Adrenal Medulla / Q000378:metabolism*; D000375:Aging; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001854:Bone Marrow Cells / Q000166:cytology* / Q000473:pathology; D002395:Catecholamines / Q000378:metabolism; D002470:Cell Survival; D005260:Female; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D018709:Statistics, Nonparametric; D013312:Stress, Physiological
D002395:Catecholamines