Dynamic regulation of leptin entry into brain by the blood-brain barrier.
Regulation of the transport of leptin across the blood-brain barrier (BBB) may be crucial for its effects on food ingestion and obesity and may be responsible for 'leptin resistance'. This review summarizes current studies of leptin indicating a dynamic role of the BBB. It includes evidence for its susceptibility to change by physiological stimuli such as starvation, refeeding, and time of day. Although the short form of the leptin receptor is involved in leptin transport, it appears that other mechanisms of entry also exist. Regardless, the BBB is intimately involved with the regulation of the actions of leptin.
Kastin
A J
AJ
VA Medical Center and Tulane University School of Medicine, 1601 Perdido St., 70112-1262, New Orleans, LA, USA.
Pan
W
W
D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D051379:Mice
D002352:Carrier Proteins; D020738:Leptin