Neutropenia accompanying parvovirus B19 infection after gynecologic surgery.
The hematologic data and symptoms of 7 patients seropositive for parvovirus B19 IgM antibody after gynecologic surgery were analysed. Parvovirus may have been transmitted by fibrin glue prepared from heat-treated human plasma and used for hemostasis during surgery. The peripheral blood neutrophil count decreased to below 1 x 10(9)/l between postoperative day (POD) 10 and 18, but recovered spontaneously to within the normal range. G-CSF injection was effective in preventing neutropenia or obtaining a prompt recovery. The reticulocyte count fell below 10 x 10(9)/l between POD 13 and 19, and also recovered spontaneously. A slapped-cheek rash was not observed in any of the 7 patients.
Honda
K
K
Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan.
Ishiko
O
O
Tsujimura
A
A
Hino
M
M
Hirai
K
K
Itoh
F
F
Tanaka
T
T
Ogita
S
S
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D001772:Blood Cell Count; D002648:Child; D005260:Female; D005334:Fever / Q000821:virology; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology / Q000627:therapeutic use; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D009503:Neutropenia / Q000821:virology*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000821:virology; D010322:Parvoviridae Infections / Q000150:complications* / Q000209:etiology; D016732:Parvovirus B19, Human / Q000276:immunology; D013997:Time Factors
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D016179:Granulocyte Colony-Stimulating Factor