title: Reduced-time-window sestamibi scanning for nonlocalized primary hyperparathyroidism.
abstract: BACKGROUND
  Technetium Tc 99m sestamibi scan is the standard of care for localizing parathyroid adenomas.
  
  
  METHODS
  We performed a retrospective, single-institution study of 111 consecutive patients with primary hyperparathyroidism who underwent standard sestamibi scan for localization of a parathyroid lesion. A revised protocol of reduced-time-window sestamibi scan was used in nonlocalized patients. The protocol was composed of single-view scans at 15, 30, 45, and 120 minutes and tomograms at 60 minutes.
  
  
  RESULTS
  Thirty-five patients underwent surgery at our institution. Thirty-one had adenomas, and 4 had hyperplasia. Three of 31 patients did not show localization on the standard scan and underwent reduced-time-window scans, which localized 2 more adenomas. These were confirmed at the time of surgery.
  
  
  CONCLUSIONS
  We suggest that all patients with a high degree of suspicion for a parathyroid adenoma, which is not visualized by a standard scan, undergo a reduced-time-window scan.
authors.affiliation: Department of Otorhinolaryngology, Lenox Hill Hospital, New York, New York, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kacker
authors.forename: S
authors.initials: S
authors.lastname: Scharf
authors.forename: A
authors.initials: A
authors.lastname: Komisar
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000601:surgery; D016105:Parathyroidectomy; D011379:Prognosis; D011859:Radiography; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi