title: Humoral immune responses to chicken infectious anemia virus in three strains of chickens in a closed flock.
abstract: This is a comparative study on seroconversion to chicken infectious anemia virus (CIAV) in a closed flock of specific-pathogen-free chickens undergoing a natural outbreak and after vaccination of some of these flocks with a commercial, live vaccine. The N2a strain (B21B21 haplotype) had the highest seroconversion after natural infection (94%) or vaccination (100%), followed by the P2a strain (B19B19) at 75%-82% seroconversion after natural infection and 85% seroconversion after vaccination. The S13 (B13B13) chickens were 26% seropositive after natural infection and 75% seropositive after vaccination. N2a chickens with polymerase chain reaction (PCR)-positive tissues were 97% seropositive compared to 80%-83% PCR-positive and seropositive for the P2a chickens and only 8% seropositive and PCR-positive for the S13 chickens. Seroconversion occurred at or near sexual maturity after natural infection in seven flocks studied.
authors.affiliation: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: C
authors.initials: C
authors.lastname: Cardona
authors.forename: B
authors.initials: B
authors.lastname: Lucio
authors.forename: P
authors.initials: P
authors.lastname: O'Connell
authors.forename: J
authors.initials: J
authors.lastname: Jagne
authors.forename: K A
authors.initials: KA
authors.lastname: Schat
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation; D017727:Chicken anemia virus / Q000276:immunology* / Q000302:isolation & purification; D002645:Chickens / Q000276:immunology*; D018173:Circoviridae Infections / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D004196:Disease Outbreaks / Q000662:veterinary; D016133:Polymerase Chain Reaction; D011201:Poultry Diseases / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms; D013997:Time Factors; D014765:Viral Vaccines
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines