Histologic transformation of follicular lymphoma after allogeneic bone marrow transplantation.
A 38-year-old man with refractory follicular lymphoma underwent allogeneic BMT from an HLA-identical sibling donor. He had generalized lymphadenopathy, hepatosplenomegaly and lymphoma infiltration of the marrow, all of which disappeared within 3 months following transplantation. Six months post-transplant, progressive hepatomegaly developed in the absence of splenomegaly and lymphadenopathy, and he died from hepatic failure. Autopsy disclosed diffuse large B cell lymphoma of the liver, into which the follicular lymphoma had transformed. Future issues to be investigated should include the optimal timing of allogeneic BMT for low-grade lymphomas.
Kojima
K
K
Department of Medicine, Ehime Prefectural Central Hospital, Matsuyama, Japan.
Mannami
T
T
Yoshino
T
T
Kawasaki
H
H
Sasaki
K
K
Maeda
T
T
Furuya
K
K
Harada
M
M
Hara
M
M
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D017809:Fatal Outcome; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D008099:Liver / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000473:pathology; D008297:Male; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014184:Transplantation, Homologous / Q000009:adverse effects*