On the anti-inflammatory and anti-phospholipase A(2) activity of extracts from lanostane-rich species.
We have studied extracts from three species rich in lanostane triterpenes for their activity against different in vivo models of inflammation induced by TPA, EPP and PLA(2). The inhibitory effect against PLA(2) in vitro was also studied. When the Poria cocos extract was tested against PLA(2)-induced mouse paw edema, it was active by the oral and parenteral routes. Its effect was greater in both magnitude and duration than that of Pistacia terebinthus and Ganoderma lucidum extracts. P. terebinthus was effective against chronic and acute inflammation, and according to a preliminary chromatographic analysis, its seems to be a good source of lanostane anti-inflammatory agents. G. lucidum was the least effective of the three species studied and, unlike the other two, failed to inhibit the activity of PLA(2) in vitro.
Giner-Larza
E M
EM
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Valencia, Spain.
Máñez
S
S
Giner-Pons
R M
RM
Carmen Recio
M
M
Ríos
J L
JL
D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D007263:Infusions, Parenteral; D051379:Mice; D010741:Phospholipases A / Q000037:antagonists & inhibitors* / Q000633:toxicity; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D014315:Triterpenes / Q000008:administration & dosage / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D014315:Triterpenes; D010741:Phospholipases A