Studies of MAL gene in human esophageal cancer by RNA in situ hybridization.
OBJECTIVE
To observe the expression of MAL gene mRNA in esophageal cancer tissue and adjacent epithelial mucosa.


METHODS
Non-radioactive RNA in situ hybridization.


RESULTS
MAL gene was expressed in all epithelia of 33 matched samples but only in 8 of esophageal cancer tissues. Differential expression between esophageal cancer tissues and adjacent epithelia was not related to clinical parameters.


CONCLUSIONS
Down-regulation of MAL may be an important event in the development of esophageal cancer.
Wang
Z
Z
Department of Molecular Oncology, Institute of Cancer, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 P.R.China. wangmr@pubem.cicams.ac.cn
Wang
M
M
Xu
X
X
Xu
Z
Z
Han
Y
Y
Cai
Y
Y
Sun
Y
Y
Wu
M
M
D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017403:In Situ Hybridization; D026901:Membrane Transport Proteins; D009185:Myelin Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D011510:Proteolipids / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis
C569026:MAL protein, human; D026901:Membrane Transport Proteins; D009185:Myelin Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D011510:Proteolipids; D012333:RNA, Messenger