title: Effects of aortic nerve on hemodynamic response to obstructive apnea in sedated pigs.
abstract: In this study we test the hypothesis that aortic nerve traffic is responsible for the pressor response to periodic apneas. In nine intubated, sedated chronically instrumented pigs, periodic obstructive apneas were caused by occlusion of the endotracheal tube for 30 s, followed by spontaneous breathing for 30 s. This was done under control (C) conditions, after section of the aortic nerve (ANS), and after bilateral cervical vagotomy (Vagot). Blood-gas tensions and airway pressure changed similarly under all conditions: PO(2) decreased to 50-60 Torr, PCO(2) increased to approximately 55 Torr, and airway pressure decreased by 40-50 mmHg during apnea. With C, mean arterial pressure (MAP) increased from 111 +/- 4 mmHg at baseline to 120 +/- 5 mmHg at late apnea (P < 0.01). After ANS and Vagot, there was no change in MAP with apneas compared with baseline. Relative to baseline, cardiac output and stroke volume decreased with C but not with ANS or Vagot during apneas. Increased MAP was due to increased systemic vascular resistance. Heart rate behaved similarly with C and ANS, being greater at early interapnea than late apnea. With Vagot, heart rate increased throughout the apnea-interapnea cycle relative to baseline. We conclude that, in sedated pigs, aortic nerve traffic mediates the increase in MAP and systemic vascular resistance observed during periodic apneas. Increase in MAP is responsible for decreased cardiac output and stroke volume. Additional vagal reflexes, most likely parasympathetic efferents, are responsible for interacting with sympathetic excitatory influences in modulating heart rate.
authors.affiliation: Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, Hew Hyde Park, New York 11042, USA.
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: S M
authors.initials: SM
authors.lastname: Scharf
mesh_terms: D000818:Animals; D001011:Aorta / Q000294:innervation*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D001239:Inhalation / Q000502:physiology; D010100:Oxygen / Q000097:blood; D015656:Respiratory Mechanics / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D013318:Stroke Volume; D013552:Swine; D014628:Vagotomy; D014655:Vascular Resistance
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen