title: [Cerebrogenic disorders of cardiac rhythm and conductivity in epilepsy patients].
abstract: 51 epileptic patients aged 16-32 years without any signs of cardiovascular pathology were examined. The primary generalized epilepsy was diagnosed in 24 cases while a partial one--in 27 patients. Were examined a state of the heart (echo- and electrocardiography, Holter's monitoring of ECG), of the brain (computed echoencephalography, visual evoked potentials) and of the autonomic nervous system (variability of cardiac rhythm, autonomic tonus). A control group included 15 healthy individuals. Significantly higher prevalence of the disorders of the cardiac rhythm and conduction was found in patients with epilepsy as compared with a control group (p < 0.001). More frequently there were sino-atrial blocks of the II degree of the I type (p < 0.01), heterotopic rhythms (p < 0.05), supraventricular extrasystole (p < 0.1), supraventricular paroxysmal tachycardia (p < 0.05), supraventricular migration of the pacemaker (p < 0.01). It was found that close relationship between cardiac arrhythmias and epilepsy was mobided by a complex of pathophysiologic mechanisms. Among them a leading role belongs to dysfunction of suprasegmental autonomic centers with a predominant activation of sympathetic or parasympathetic departments of the autonomic nervous system. Significant arrhythmogenic factors appeared to be: presence of organic damages in the brain, frequency of epileptic fits, dysfunction of suprasegmental autonomic centers with activation of cerebral ergotropic systems.
authors.forename: V V
authors.initials: VV
authors.lastname: Shprakh
authors.forename: A V
authors.initials: AV
authors.lastname: Sin'kov
authors.forename: G M
authors.initials: GM
authors.lastname: Sin'kova
mesh_terms: D000293:Adolescent; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D002908:Chronic Disease; D004452:Echocardiography; D004453:Echoencephalography; D004562:Electrocardiography; D004828:Epilepsies, Partial / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D004829:Epilepsy, Generalized / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D005074:Evoked Potentials, Visual; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male