title: Cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma: a pilot study.
abstract: Sixteen dogs with histologically confirmed appendicular osteosarcoma were treated by amputation followed by cisplatin and doxorubicin chemotherapy. All dogs began chemotherapy within 24 hours of surgery. Cisplatin was administered at 50 mg/m2 intravenously (IV) concurrent with saline-induced diuresis. Doxorubicin was administered 24 hours later at 15 mg/m2 as a slow IV bolus. This protocol was given on a 21-day cycle for 4 cycles. No dose delays were required, but dose reduction of doxorubicin was required in 2 dogs because of neutropenia. Thoracic radiography was performed every 2 months after completion of therapy to monitor for metastatic disease. Two dogs were still alive and free from disease at the time of last contact (24 and 75 months, respectively). Postmortem examinations were performed on 13 of the 14 dogs that died. Eight of these dogs were euthanized because of metastatic osteosarcoma. Of the remaining 5 dogs, euthanasia was performed because of complications of idiopathic megaesophagus (n = 1), arthritis (n = 2), and hemangiosarcoma (n = 2). The median disease-free interval and survival times were 15.7 and 18 months, respectively. When compared to a historical group of 36 dogs with appendicular osteosarcoma treated with surgery and 4 doses of cisplatin. both disease-free interval and overall survival were significantly longer in the study population (P < .015 and P < .007, respectively).
authors.affiliation: Kansas State University, Manhattan, USA. chun@vet.ksu.edu
authors.forename: R
authors.initials: R
authors.lastname: Chun
authors.forename: I D
authors.initials: ID
authors.lastname: Kurzman
authors.forename: C G
authors.initials: CG
authors.lastname: Couto
authors.forename: J
authors.initials: J
authors.lastname: Klausner
authors.forename: C
authors.initials: C
authors.lastname: Henry
authors.forename: E G
authors.initials: EG
authors.lastname: MacEwen
mesh_terms: D000671:Amputation, Surgical / Q000662:veterinary; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage; D005269:Femur / Q000473:pathology; D006811:Humerus / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D012516:Osteosarcoma / Q000188:drug therapy / Q000556:secondary / Q000662:veterinary*; D010865:Pilot Projects; D016016:Proportional Hazards Models; D013902:Radiography, Thoracic / Q000662:veterinary; D011884:Radius / Q000473:pathology; D011897:Random Allocation; D013977:Tibia / Q000473:pathology
chemical_list: D004317:Doxorubicin; D002945:Cisplatin