title: [Pharmacological protection of the brain during surgery in patients with giant cerebral aneurysms].
abstract: The authors discuss the results of pharmacological protection of the brain, consisting in intraarterial or intravenous infusion of drugs (sodium thiopental, nimodipine, ketamine) during intracranial interventions in 13 patients with giant arterial aneurysms of the anterior portions of Willis' circle. In some patients drug protection of the brain prevented the development of ischemic focus in the basin of temporarily occluded vessel. Intraarterial infusion of protector drugs is preferable because it allows decreasing the doses and severity of untoward hemodynamic effects.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Lubnin
authors.forename: A V
authors.initials: AV
authors.lastname: Shmigel'skiĭ
authors.forename: O B
authors.initials: OB
authors.lastname: Sazonova
authors.forename: Sh Sh
authors.initials: ShSh
authors.lastname: Eliava
authors.forename: V A
authors.initials: VA
authors.lastname: Lazarev
authors.forename: S P
authors.initials: SP
authors.lastname: Zolotukhin
authors.forename: A A
authors.initials: AA
authors.lastname: Dausheva
mesh_terms: D000328:Adult; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D002545:Brain Ischemia / Q000517:prevention & control; D002648:Child; D002941:Circle of Willis; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D002532:Intracranial Aneurysm / Q000601:surgery*; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000008:administration & dosage / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D014665:Vasodilator Agents; D009553:Nimodipine; D007649:Ketamine; D013874:Thiopental