title: Human papillomavirus type 33 DNA in breast cancer in Chinese.
abstract: BACKGROUND
  The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer.
  
  
  METHODS
  We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China.
  
  
  RESULTS
  DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer.
  
  
  CONCLUSIONS
  Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.
authors.affiliation: Department of Pathology, Shanghai First People's Hospital, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: T
authors.initials: T
authors.lastname: Morimoto
authors.forename: M
authors.initials: M
authors.lastname: Sasa
authors.forename: K
authors.initials: K
authors.lastname: Okazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Irie
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
authors.forename: A
authors.initials: A
authors.lastname: Tanigami
authors.forename: K
authors.initials: K
authors.lastname: Izumi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D001943:Breast Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000821:virology*; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000208:ethnology / Q000821:virology*; D002681:China / Q000453:epidemiology; D015344:DNA Probes, HPV; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification*; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D005814:Genes, Viral; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000208:ethnology / Q000821:virology*; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000208:ethnology / Q000821:virology*
chemical_list: D015344:DNA Probes, HPV; D004273:DNA, Neoplasm; D004279:DNA, Viral