title: Optic disc vasculitis.
abstract: BACKGROUND
  Our studies had indicated that optic disc vasculitis (ODV) is a distinct clinical entity. We investigated the presentation and clinical characteristics of ODV and determined the efficacy of systemic corticosteroids in its management.
  
  
  METHODS
  From 1973 to 1997, we investigated 32 patients (34 eyes) with ODV. The information was obtained by complete medical and ophthalmic history taking and a detailed ophthalmic examination at the initial and follow-up visits. Non-parametric analysis of demographic characteristics and Cox proportional hazard modeling of treatment outcomes was performed.
  
  
  RESULTS
  The most common presenting symptom was blurred vision (in 31/34 eyes--91.2%). Visual acuity was 6/12 or better in 82.4% and 6/30 or better in 94.1% of the eyes. All eyes had an enlarged blind spot, vitreous cells and optic disc edema. Fluorescein angiography demonstrated retinal peripapillary phlebitis in 52.6% of the eyes. Systemic hypertension in young patients (P=0.004) and frequency of smoking (P=0.004 for males, P=0.046 for females) were significantly higher than in the general population. Treatment with systemic corticosteroids improved the rate of resolution of optic disc edema and vitreous cells, reducing median resolution times (P=0.042). There was a tendency towards improved central visual fields with treatment (P=0.09). Final visual acuity was 6/12 or better in 25 (92.6%) and 6/18 or better in all of the 27 eyes followed by us.
  
  
  CONCLUSIONS
  Our study indicates that our cases represent a distinct clinical entity of ODV and not just a potpourri of unilateral optic disc edema of different etiologies. It is a self-limiting disease, usually with good prognosis, and benefits from treatment with systemic corticosteroids. The presence of retinal peripapillary phlebitis on fluorescein angiography suggests mild vasculitis of the optic nerve head as the primary pathological mechanism in this disorder.
authors.affiliation: Department of Ophthalmology and Visual Sciences, College of Medicine, University of Iowa, Iowa City 52242, USA.
authors.forename: K T
authors.initials: KT
authors.lastname: Oh
authors.forename: D M
authors.initials: DM
authors.lastname: Oh
authors.forename: S S
authors.initials: SS
authors.lastname: Hayreh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000098:blood supply*; D009901:Optic Nerve Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010211:Papilledema / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D011379:Prognosis; D012189:Retrospective Studies; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D014792:Visual Acuity; D014794:Visual Fields; D014822:Vitreous Body / Q000473:pathology
chemical_list: D005938:Glucocorticoids