Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling.
Liu
W
W
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Medical School, Rochester, Minnesota, USA. liu.wanguo@mayo.edu
Dong
X
X
Mai
M
M
Seelan
R S
RS
Taniguchi
K
K
Krishnadath
K K
KK
Halling
K C
KC
Cunningham
J M
JM
Boardman
L A
LA
Qian
C
C
Christensen
E
E
Schmidt
S S
SS
Roche
P C
PC
Smith
D I
DI
Thibodeau
S N
SN
D060466:Axin Protein; D020137:Base Pair Mismatch / Q000235:genetics*; D002460:Cell Line; D015179:Colorectal Neoplasms / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology*; D004252:DNA Mutational Analysis; D004260:DNA Repair / Q000235:genetics*; D017930:Genes, Reporter; D006801:Humans; D009154:Mutation; D015398:Signal Transduction; D051820:TCF Transcription Factors; D015534:Trans-Activators; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors / Q000502:physiology*; D014162:Transfection; D051176:beta Catenin
C491761:AXIN2 protein, human; D060466:Axin Protein; C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D051820:TCF Transcription Factors; C544894:TCF7L2 protein, human; D015534:Trans-Activators; D058118:Transcription Factor 7-Like 2 Protein; D014157:Transcription Factors; D051176:beta Catenin