The thin red line: angiogenesis in normal and malignant hematopoiesis.
This review describes the current knowledge about cell subsets involved in vasculogenesis (i.e., differentiation of endothelial cells from mesodermal precursors) and angiogenesis (i.e., blood vessel generation from pre-existing vessels), together with recent findings about angiogenesis and antiangiogenic therapies in hematopoietic malignancies such as leukemia, lymphoma, myeloma, and myelodysplastic syndromes.
Bertolini
F
F
Division of Hematology-Oncology, IRCCS European Institute of Oncology, Milan, Italy. francesco.bertolini@ieo.it
Mancuso
P
P
Gobbi
A
A
Pruneri
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D019337:Hematologic Neoplasms / Q000503:physiopathology*; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000502:physiology; D013234:Stem Cells / Q000276:immunology / Q000502:physiology
D000970:Antineoplastic Agents