title: Radiation damping compensation of selective pulses in water-protein exchange spectroscopy.
abstract: The observation of nuclear Overhauser effects (NOEs) between bound water and biological macromolecules such as proteins and nucleic acids can be improved by inverting the water resonance selectively while compensating for radiation damping effects. The efficiency of inversion, the offset profiles, and the appearance of 2D NOE-NOESY spectra can be improved in comparison with earlier methods.
authors.affiliation: Section de Chimie, Université de Lausanne, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Cutting
authors.forename: J H
authors.initials: JH
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Moskau
authors.forename: G
authors.initials: G
authors.lastname: Bodenhausen
mesh_terms: D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012996:Solutions; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry* / Q000378:metabolism
chemical_list: D011506:Proteins; D012996:Solutions; D012997:Solvents; D014867:Water