title: Glucagon-producing neuroendocrine tumour associated with hypoaminoacidaemia and skin lesions.
abstract: A nine-year-old neutered female crossbred Bernese mountain dog was diagnosed with superficial necrolytic dermatitis and a glucagon-producing islet cell tumour. Laboratory findings included hyperglucagonaemia and hypoaminoacidaemia. The dog was euthanased because of progression of the disease, and necropsy revealed liver metastases of a neuroendocrine carcinoma with immunohistochemical expression of glucagon and somatostatin. This report represents a case of canine glucagonoma syndrome; the previously reported cases in dogs are also briefly described.
authors.affiliation: Department of Internal Medicine, Faculty of Veterinary Medicine, University of Zurich, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Allenspach
authors.forename: P
authors.initials: P
authors.lastname: Arnold
authors.forename: T
authors.initials: T
authors.lastname: Glaus
authors.forename: B
authors.initials: B
authors.lastname: Hauser
authors.forename: C
authors.initials: C
authors.lastname: Wolff
authors.forename: C
authors.initials: C
authors.lastname: Eberle
authors.forename: P
authors.initials: P
authors.lastname: Komminoth
mesh_terms: D007516:Adenoma, Islet Cell / Q000473:pathology / Q000662:veterinary*; D000596:Amino Acids / Q000097:blood; D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D005934:Glucagon / Q000096:biosynthesis*; D005935:Glucagonoma / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D009336:Necrosis; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000662:veterinary*; D013004:Somatostatin / Q000096:biosynthesis
chemical_list: D000596:Amino Acids; D013004:Somatostatin; D005934:Glucagon