title: Results of transurethral injection of silicone micro-implants for females with intrinsic sphincter deficiency.
abstract: OBJECTIVE
  We evaluated the medium term efficiency of silicone micro-implants injected in women with intrinsic sphincter deficiency.
  
  
  METHODS
  A total of 21 women with intrinsic sphincter deficiency underwent transurethral injection of silicone micro-implants between August 1996 and February 1997. Each patient was assessed preoperatively by questionnaire, physical examination and urodynamic study. The results were evaluated by questionnaire at 1 month, and 1 and 2 years after silicone injection. The outcome was classified as dry in all circumstances, improved or failure.
  
  
  RESULTS
  All patients (median age 68 years, range 46 to 83) had undergone previous anti-incontinence or prolapse surgeries. At 1 month 2 patients (10%) were dry and 9 (42%) were improved, and treatment failed in 10 (48%). At 1 year (median 16 months, range 14 to 22) 2 cases (10%) were classified as dry, 8 (38%) improved and 11 (52%) failures. At last followup (median 31 months, range 24 to 34) 4 cases (19%) were classified as dry, 6 (29%) improved and 11 (52%) failures. None of the 6 patients with bladder neck hypermobility was dry.
  
  
  CONCLUSIONS
  Our results of silicone transurethral injection are disappointing but comparable to other bulking agents without a time dependent decrease in efficiency. The use of silicone micro-implants is an alternative for the treatment of intrinsic sphincter deficiency in patients without bladder neck hypermobility and in whom the sling procedure has failed.
authors.affiliation: Unité d'urogynécologie and Département de Gynécologie-Obstétrique, Hôpital Rothschild, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Barranger
authors.forename: X
authors.initials: X
authors.lastname: Fritel
authors.forename: O
authors.initials: O
authors.lastname: Kadoch
authors.forename: Y
authors.initials: Y
authors.lastname: Liou
authors.forename: A
authors.initials: A
authors.lastname: Pigné
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005782:Gels / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D019736:Prostheses and Implants; D012828:Silicones / Q000627:therapeutic use*; D017211:Treatment Failure; D001743:Urinary Bladder / Q000503:physiopathology*; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics
chemical_list: D005782:Gels; D012828:Silicones; C078211:polymethylsiloxane