title: [Immunopharmacologic properties of 12-iminosubstituted 8-aza-D-homogonan and trimezon].
abstract: The immunopharmacological properties of two new compounds with an 8-azasteroidal structure, representing the salts (hydrochloride and acetate) of 12-imino-substituted 8-aza-D-homogonan, were studied in comparison with the properties of the immunostimulant trimeson. Similar to trimeson, both new compounds produce a dose-dependent activation of the humoral chain of immunogenesis in the model of primary immune response to goat erythrocytes in CBA, C57BL/6, and C57W mice. The immunostimulant activity of the 8-aza-D-homogonan derivatives is inversely proportional to the antigen load (2 x 10(7)-2 x 10(9) goat erythrocytes per mice) and depends to a considerable extent of the genotype of experimental animals. A modification of the 8-aza-D-homogonan structure by substituting imino group for oxygen at position 12 of the 8-azasteroidal skeleton leads to a sharp increase in toxicity as compared to that of trimeson.
authors.affiliation: Department of Biological Tests, Academy of Sciences of Belarus, Minsk, Belarus.
authors.forename: G S
authors.initials: GS
authors.lastname: Liubin
authors.forename: N A
authors.initials: NA
authors.lastname: Konoplia
authors.forename: O V
authors.initials: OV
authors.lastname: Guliakevich
authors.forename: B B
authors.initials: BB
authors.lastname: Kuz'mitskiĭ
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001372:Aza Compounds / Q000494:pharmacology* / Q000633:toxicity; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005838:Genotype; D006041:Goats; D007928:Lethal Dose 50; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity; D013256:Steroids / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000276:Adjuvants, Immunologic; D001372:Aza Compounds; D013256:Steroids; C087739:trimezon