title: Levels of interleukin (IL)-6, IL-8, and IL-1 receptor antagonist in the hepatic vein following liver surgery.
abstract: OBJECTIVE
  The liver produces various cytokines, but local changes in the concentrations of these reaction products after liver surgery are unknown. We investigated the local changes of interleukin-6, interleukin-8 and interleukin-1 receptor antagonist after liver surgery.
  
  
  METHODS
  We determined levels of interleukin-6, interleukin-8, and interleukin-1 receptor antagonist in the hepatic vein and radial artery after liver resection in 13 patients. These cytokine levels in the portal vein were also measured in 6 patients.
  
  
  RESULTS
  Interleukin-6, interleukin-8, and interleukin-1 receptor antagonist levels were significantly increased during liver surgery (P < 0.05). The level of interleukin-6 was significantly lower in the hepatic vein than in the radial artery as well as in the portal vein at the end of the operation (P < 0.05, < 0.03). The level of interleukin-8 and interleukin-1 receptor antagonist was significantly higher in the hepatic vein than in the artery (P < 0.05).
  
  
  CONCLUSIONS
  Interleukin-6 may be taken up by the liver after liver surgery, and the difference between hepatic venous and peripheral arterial interleukin-6 levels may be an indicator of liver regeneration after liver resection. Interleukin-8 and interleukin-1 receptor antagonist appear to be produced in the remaining liver.
authors.affiliation: Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Sakabe
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Nishida
authors.forename: F
authors.initials: F
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Maekawa
mesh_terms: D000368:Aged; D004564:Electrocoagulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006498:Hepatectomy; D006499:Hepatic Artery / Q000378:metabolism*; D006503:Hepatic Veins / Q000378:metabolism*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000601:surgery*; D008297:Male; D008872:Microwaves; D008875:Middle Aged; D011169:Portal Vein / Q000378:metabolism; D017534:Radial Artery; D012795:Sialoglycoproteins / Q000097:blood*; D018709:Statistics, Nonparametric
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6; D016209:Interleukin-8; D012795:Sialoglycoproteins