[Effect of pyrimidine derivatives on the skin reparative regeneration during stress in laboratory animals].
Experiments on rats showed that some pyrimidine derivatives stimulate the skin repair in animals with thermal and chemical burns under stress conditions. The efficacy of compounds tested increases in the following order: 2-methyl-4-amino-6-hydroxypyrimidine < hydroxymethyluracil < methyluracil.
Ismagilova
A F
AF
Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, Bashkortostan, Russia.
Belov
A E
AE
Zarudií
F S
FS
Ismagilova
L U
LU
Krivonogov
V P
VP
Khalimov
R F
RF
Tolstikov
G A
GA
Tropynina
Iu V
IuV
D000818:Animals; D002056:Burns / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006358:Hot Temperature; D006851:Hydrochloric Acid; D008297:Male; D010432:Pentoxyl / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D013312:Stress, Physiological / Q000150:complications / Q000473:pathology*; D014498:Uracil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
C096002:2-methyl-6-amino-6-hydroxypyrimidine; D011743:Pyrimidines; C008055:5-hydroxymethyluracil; D014498:Uracil; C008378:6-methyluracil; D010432:Pentoxyl; D006851:Hydrochloric Acid