title: Large granular lymphocyte leukemia and its association with oral neutropenic ulcerations: a case report.
abstract: Large granular lymphocyte leukemia is a rare chronic indolent disorder commonly associated with severe neutropenia. The pathogenesis of the neutropenia is unclear. A case is presented of a 74-year-old man who had recurrent oral ulcerations for over a year before a diagnosis was made. These recurrent oral ulcers cleared with treatment and have not returned. The differential diagnosis of persistent oral ulcerations includes trauma; viral, fungal, and bacterial infections; systemic disease; or various malignant conditions. The oral ulcers in this man were likely infectious in nature and related to the severe chronic neutropenia. This case serves to illustrate the potentially complex nature of oral ulcers.
authors.affiliation: University of Saskatchewan, Department of Diagnostic and Surgical Sciences, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Copete
authors.forename: D P
authors.initials: DP
authors.lastname: Sheridan
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003937:Diagnosis, Differential; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000473:pathology*; D008048:Lip Neoplasms / Q000150:complications / Q000473:pathology*; D008297:Male; D009503:Neutropenia / Q000150:complications*; D019226:Oral Ulcer / Q000150:complications / Q000209:etiology / Q000473:pathology*; D012008:Recurrence