title: Cerebral autoregulation in subjects adapted and not adapted to high altitude.
abstract: OBJECTIVE
  Impaired cerebral autoregulation (CA) from high-altitude hypoxia may cause high-altitude cerebral edema in newcomers to a higher altitude. Furthermore, it is assumed that high-altitude natives have preserved CA. However, cerebral autoregulation has not been studied at altitude.
  
  
  METHODS
  We studied CA in 10 subjects at sea level and in 9 Sherpas and 10 newcomers at an altitude of 4243 m by evaluating the effect of an increase of mean arterial blood pressure (MABP) with phenylephrine infusion on the blood flow velocity in the middle cerebral artery (Vmca), using transcranial Doppler. Theoretically, no change of Vmca in response to an increase in MABP would imply perfect autoregulation. Complete loss of autoregulation is present if Vmca changes proportionally with changes of MABP.
  
  
  RESULTS
  In the sea-level group, at a relative MABP increase of 23+/-4% during phenylephrine infusion, relative Vmca did not change essentially from baseline Vmca (2+/-7%, P=0.36), which indicated intact autoregulation. In the Sherpa group, at a relative MABP increase of 29+/-7%, there was a uniform and significant increase of Vmca of 24+/-9% (P<0.0001) from baseline Vmca, which indicated loss of autoregulation. The newcomers showed large variations of Vmca in response to a relative MABP increase of 21+/-6%. Five subjects showed increases of Vmca of 22% to 35%, and 2 subjects showed decreases of Vmca of 21% and 23%.
  
  
  CONCLUSIONS
  All Sherpas and the majority of the newcomers showed impaired CA. It indicates that an intact autoregulatory response to changes in blood pressure is probably not a hallmark of the normal human cerebral vasculature at altitude and that impaired CA does not play a major role in the occurrence of cerebral edema in newcomers to the altitude.
authors.affiliation: Department of Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands.
authors.forename: G F
authors.initials: GF
authors.lastname: Jansen
authors.forename: A
authors.initials: A
authors.lastname: Krins
authors.forename: B
authors.initials: B
authors.lastname: Basnyat
authors.forename: A
authors.initials: A
authors.lastname: Bosch
authors.forename: J A
authors.initials: JA
authors.lastname: Odoom
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects / Q000502:physiology*; D000328:Adult; D000531:Altitude; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D005260:Female; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000502:physiology*; D010656:Phenylephrine / Q000008:administration & dosage; D012146:Rest / Q000502:physiology; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D010656:Phenylephrine