Seventeen years' experience with Autoplex/Autoplex T: evaluation of inpatients with severe haemophilia A and factor VIII inhibitors at a major haemophilia centre.
A retrospective case analysis of the use of Autoplex T (anti-inhibitor coagulant complex [heat treated]) at a major haemophilia treatment centre is described. Twenty-three haemophilia A patients with a history of high-titre (>10 BU), high-response inhibitors were treated for a total of 54 bleeding episodes requiring hospital admission and/or surgical intervention. Effective or partially effective haemostatic control was achieved within 72 h in 94% of reported cases (effective 85%; partially effective 9%). The incidence of adverse reactions was low and there were no thrombotic complications. In bleeding episodes for which BU titres were determined within 6 months pre- and 6 months post-treatment, there was little tendency for Autoplex T to cause an anamnestic response (1 of 19 bleeding episodes). In the three invasive surgical procedures included in the case review, coverage with Autoplex T resulted in no postoperative complications, no bleeding at the surgical site, and no postoperative haematoma. The results support the efficacy and safety of Autoplex T in the treatment of bleeding episodes and haemostatic coverage of surgical procedures in haemophilia A patients with inhibitors.
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Division of Hematology-Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599-7035, USA.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000008:administration & dosage* / Q000009:adverse effects / Q000592:standards*; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D004342:Drug Hypersensitivity / Q000209:etiology; D005169:Factor VIII / Q000276:immunology; D006467:Hemophilia A / Q000188:drug therapy / Q000276:immunology / Q000601:surgery; D006470:Hemorrhage / Q000209:etiology / Q000276:immunology / Q000628:therapy; D006801:Humans; D007223:Infant; D007518:Isoantibodies / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D001779:Blood Coagulation Factors; D007518:Isoantibodies; C025667:prothrombin complex concentrates; D005169:Factor VIII