[Bioavailability evaluation of dermocorticoids using differential infrared thermography].
BACKGROUND
Differential infrared thermography, proposed in this paper, is a technique based on direct observations of infrared radiations emitted by the skin. The evolution of cutaneous temperature caused by the application of dermocorticoids on healthy skin demonstrates their pharmaco-dynamic properties.


METHODS
The cutaneous thermal image was recorded in real time. Image processing using subtraction function readily provided differential infrared thermographic analysis of the effects. Four activity classes of dermocorticoids had been applied on healthy skin. A test immediately carried out after dermocorticoid application on skin without occlusion and the classical skin blanching-test have been performed.


RESULTS
Temperature differences between the dermocorticoids were detected within the first three hours after the application on the skin without occlusion. The dermocorticoid class II cream formulation under study induced a decrease in temperature more pronounced than the others dermocorticoids. The skin-blanching effect was more noticeable for dermocorticoids class I and II and it was not detected for class IV.


CONCLUSIONS
Subtraction thermograms provide a means of differential imaging. Evolutive temperature differences subsequent to unique application without dermocorticoid occlusion are evidenced during a short duration (the first three hours). This may correspond to efficacy differences while classical tests of vasoconstriction analyse the cutaneous blanching induced after the 6th hour. Concerning the skin-blanching effect, results of this first investigation are not sufficient for a precise qualitative and quantitative interpretation. The main interest of differential infrared thermography is to be quantitative, without contact, continuous in real time. Differential infrared thermography is more sensitive than classical thermography. It allowed an objective evolution survey for dermocorticoids.
Luong
M S
MS
Service de Dermatologie et Vénéréologie, CHRU, Hôpital Sud, 80054 Amiens Cedex 1.
Luong
M P
MP
Lok
C
C
Carmi
E
E
Chaby
G
G
Viseux
V
V
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D004867:Equipment Design; D005938:Glucocorticoids; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D012881:Skin Temperature / Q000187:drug effects*; D013256:Steroids; D013817:Thermography / Q000295:instrumentation*
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D013256:Steroids