title: Gastric outlet obstruction and pulmonary infiltrate in a patient with Crohn's disease: successful treatment by Billroth-II-resection.
abstract: We present a 28-year-old women with a 3 yr history of duodenal ulcers. Following four treatment attempts to eradicate helicobacter pylori she was admitted because of gastric outlet obstruction and a weight loss of 20 kg within the last two years. Endoscopy and x-ray showed a circular inflammatory stenosis of the proximal duodenum extending over 8 cm. Additionally, chest x-ray showed a circumscript infiltrate in the third segment of the right lung. Mycobacterial infection could be excluded. Ileocolonoscopy and small intestinal follow-through beyond the duodenum were unremarkable, and Zollinger-Ellison-syndrome was ruled out. Bronchopulmonary histology showed intramucosal epithelioid-cell granulomas and bronchiolitis obliterans. Because the patient did not improve under conservative therapy a Billroth-II-resection was carried out. Histologically the resected specimen showed Crohn-like lesions. Postoperatively, severe peripheral arthritis was treated by steroids over 6 weeks. At follow-up the patient regained 20 kg and was free of symptoms without any medication. The pulmonary infiltrate had subsided almost completely. In summary, this extremely rare coincidence of isolated stenosing duodenal Crohn's disease and pulmonary involvement was successfully treated by Billroth-II-resection. This course of disease is compatible with the hypothesis that Crohn's disease may be maintained by antigens derived from ingested food.
authors.affiliation: IV. Medizinische Klinik, Charité, Berlin, Germany.
authors.forename: W A
authors.initials: WA
authors.lastname: Voderholzer
authors.forename: C
authors.initials: C
authors.lastname: Zietz
authors.forename: H E
authors.initials: HE
authors.lastname: Feucht
authors.forename: W
authors.initials: W
authors.lastname: Heldwein
authors.forename: H
authors.initials: H
authors.lastname: Hallfeldt
authors.forename: R M
authors.initials: RM
authors.lastname: Huber
authors.forename: K
authors.initials: K
authors.lastname: Loeschke
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D003937:Diagnosis, Differential; D004386:Duodenum / Q000473:pathology; D005260:Female; D005743:Gastrectomy; D017219:Gastric Outlet Obstruction / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D013270:Stomach / Q000473:pathology