title: [Update endocrinology I (Neuroendocrinology)].
abstract: BACKGROUND
  Presentation of current data and knowledge in the field of experimental and clinical neuroendocrinology.
  
  
  OBJECTIVE
  Overview of current data on the pathogenesis and therapeutic strategies of pituitary disorders. 1. Hypothalamic and pituitary regulation: characterization of influence of hormone secretion and cell proliferation of anterior pituitary cells by an intrapituitary network of cytokines and growth factors. Special importance on the role of the interleukin-6-family. Characterization of the role of gaseous transmitters in neuroendocrinology. 2. Molecular pathogenesis of pituitary adenomas: presentation of the current knowledge status with regard to familial syndromes. 3. Therapy of pituitary adenomas: presentation of new developments of therapeutic aspects, in particular medical treatment, surgery and radiation. Outlook on the future role of gene therapy. 4. Growth hormone replacement in adults: short overview of diagnosis and therapy of growth hormone deficiency in the adult.
authors.affiliation: Klinik für Endokrinologie und Stoffwechselkrankheiten, Otto-von-Guericke-Universität Magdeburg.
authors.forename: A
authors.initials: A
authors.lastname: Hanisch
authors.forename: H
authors.initials: H
authors.lastname: Lehnert
authors.forename: J
authors.initials: J
authors.lastname: Hensen
mesh_terms: D000172:Acromegaly / Q000188:drug therapy / Q000209:etiology; D000236:Adenoma / Q000188:drug therapy / Q000378:metabolism; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism; D020249:Hormone Replacement Therapy / Q000379:methods; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D009452:Neuroendocrinology / Q000639:trends*; D018377:Neurotransmitter Agents / Q000235:genetics / Q000378:metabolism; D009609:Nitrous Oxide / Q000378:metabolism; D010900:Pituitary Diseases / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000378:metabolism; D015175:Prolactinoma / Q000188:drug therapy / Q000378:metabolism
chemical_list: D016207:Cytokines; D006133:Growth Substances; D018377:Neurotransmitter Agents; D019382:Human Growth Hormone; D009609:Nitrous Oxide