title: Biological activity of myricetin and its derivatives against human leukemic cell lines in vitro.
abstract: Two myricetin derivatives, the 3,7, 4('), 5(')- tetramethyl ether of myricetin (1), isolated from the hexane extract of Cistus monspeliensis, and its 3('),5-diacetyl derivative (2) which was synthesized, and the parent compound, myricetin (3), were examined for their in vitro cytotoxic activity against nine human leukemic cell lines, two of which were mdr cell lines. Compound 2 exhibited higher cytostatic and cytotoxic activities in comparison to compound 1, while compound 3 was inactive against all tested cell lines. Vinblastine was used as a control.
authors.affiliation: International Institute of Anticancer Research, Kapandriti, Attiki, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Dimas
authors.forename: C
authors.initials: C
authors.lastname: Demetzos
authors.forename: D
authors.initials: D
authors.lastname: Angelopoulou
authors.forename: A
authors.initials: A
authors.lastname: Kolokouris
authors.forename: T
authors.initials: T
authors.lastname: Mavromoustakos
mesh_terms: D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D019660:Malvaceae / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; C040015:myricetin