In vitro iontophoretic release of lithium chloride and lidocaine hydrochloride from polymer electrolytes.
Ionically conducting polymers, frequently known as polymer electrolytes, are potential candidates as hosts for drugs to be delivered iontophoretically. The iontophoretic delivery of lithium or lidocaine from polymer electrolyte films through a cellophane membrane was examined using different delivery current regimes. Thin, mechanically strong, polymer electrolyte films were fabricated from poly(ethylene oxide) (PEO) with lithium chloride or lidocaine hydrochloride. Experiments showed that iontophoretic transport of both lithium chloride and lidocaine hydrochloride might be achieved from these PEO-based films. Cation transport number determinations give values for PEO-based films of about 0.4 for lithium chloride systems and 0.12 for lidocaine hydrochloride systems. The mechanism of transport from these PEO-based polymer electrolyte films allows the delivery of ionic salts such as lithium chloride and lidocaine hydrochloride to be controlled solely by current, thus providing a system that can deliver precise amounts of drug.
Sahota
T S
TS
Solid State Research Centre, Faculty of Applied Sciences, De Montfort University, Leicester, UK.
Latham
R J
RJ
Linford
R G
RG
Taylor
P M
PM
D000779:Anesthetics, Local / Q000493:pharmacokinetics*; D018692:Antimanic Agents / Q000493:pharmacokinetics*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004573:Electrolytes; D006801:Humans; D007478:Iontophoresis; D008012:Lidocaine / Q000493:pharmacokinetics*; D018021:Lithium Chloride / Q000493:pharmacokinetics*; D011108:Polymers
D000779:Anesthetics, Local; D018692:Antimanic Agents; D004337:Drug Carriers; D004573:Electrolytes; D011108:Polymers; D008012:Lidocaine; D018021:Lithium Chloride