Microemulsions for topical delivery of 8-methoxsalen.
8-Methoxsalen (8-MOP) and related furocumarins have been extensively used for the treatment of hyperproliferative skin diseases in association with long-wavelength UVA light. In order to develop alternative formulations for the topical administration of 8-MOP, microemulsions were evaluated as delivery vehicles. Six microemulsion formulations were prepared using water, isopropyl myristate (IPM) and Tween((R)) 80: Span((R)) 80: 1,2-Octanediol (3:1:1.2 w/w). The microemulsions were characterized using conductimetric and dynamic light scattering analyses. The ability of the systems to deliver 8-MOP into and through the skin was evaluated in vitro using newborn pig-skin. The in vitro permeation data showed that the novel microemulsions increased the 8-MOP total penetration through the skin by order of 1.9-4.5, as compared with IPM. In general, the accumulation of 8-MOP into the skin was increased by a factor of 1.5-4.5 by the microemulsion systems with respect to their total amount of drug delivered across the skin. These results suggest that the studied microemulsion systems may be appropriate vehicles for the topical delivery of 8-MOP.
Baroli
B
B
Department of Farmacia y Tecnología Farmacéutica, School of Pharmacy, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain. bbaroli@mit.edu
López-Quintela
M A
MA
Delgado-Charro
M B
MB
Fadda
A M
AM
Blanco-Méndez
J
J
D000287:Administration, Topical; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D004553:Electric Conductivity; D004655:Emulsions; D008730:Methoxsalen / Q000008:administration & dosage* / Q000737:chemistry; D014677:Pharmaceutical Vehicles; D012869:Skin Absorption; D012995:Solubility; D013552:Swine
D004655:Emulsions; D014677:Pharmaceutical Vehicles; D008730:Methoxsalen