[Kinetics of aluminum absorption and serum concentration in chronic renal insufficiency].
After administration of a single dose of an aluminium containing antacid (Tisacid) to eight non dialysis patients in various stages of chronic renal insufficiency, the kinetics of serum aluminium absorption was studied. Serum aluminium peaked at two points of time, aluminium absorption being biphasic in renal patients comparing with monophasic kinetic in controls. At the same time, already at 24 hrs after Tisacid ingestion, the aluminium concentration was almost twice as high as initially even in mild renal insufficiency. These results are at variance with the rapidly reversible, monophasic aluminium absorption observed earlier in healthy subjects and in non-renal patients with duodenal ulcer. To ward off complications, a strong warning is given against administration of any aluminium-containing medicament or food to subjects with reduced renal function.
Sárszegi
Z
Z
Pécsi Tudományegyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika.
Jobst
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K
Nagy
J
J
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000535:Aluminum / Q000097:blood* / Q000378:metabolism; D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage*; D002254:Carbonates / Q000008:administration & dosage*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000209:etiology; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013997:Time Factors
D000863:Antacids; D002254:Carbonates; C043698:almagate; D000536:Aluminum Hydroxide; D000535:Aluminum; D008276:Magnesium Hydroxide