[Preclinical toxicological study of ecorsin].
A new drug preparation ecorsin based on the dry aspen bark extract was studied for toxicological safety on a preclinical stage. The drug exhibited no toxicity upon a single administration to rats and mice (both male and female). The intragastric administration of ecorsin for 3 months to rats (at a daily dose of 50, 250, and 500 mg/kg) and rabbits (25 and 50 mg/kg) led to neither functional not morphological changes in hemopoietic and lymphoid organs, liver, kidney, heart, digestive system, and CNS. The long-term administration resulted in a partial atrophic modification of convoluted seminiferous tubules in impuberal male rats, while not affecting the testes of aged animals. The administration of ecorsin at 50, 250, and 500 mg/kg led to dose-dependent changes in some characteristics of the reproductive capacity in rats. Ecorsin did not modify the extent of allergic reactions and produced no immunotoxicant and mutagen effects.
Karpova
G V
GV
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Russia.
Fomina
T I
TI
Vetoshkina
T V
TV
Borovskaia
T G
TG
Voronova
O L
OL
Dubskaia
T Iu
TIu
Poluéktova
M E
ME
Timina
E A
EA
Smol'ianinov
E S
ES
Turetskova
V F
VF
D000818:Animals; D000897:Anti-Ulcer Agents / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests; D010936:Plant Extracts / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests; D014197:Trees / Q000737:chemistry*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts