title: [Pure red cell aplasia induced by clomipramine hydrochloride in a patient with SLE].
abstract: A 48-year-old woman, who had been suffering from systemic lupus erythematosus (SLE), developed normochromic normocytic anemia after receiving clomipramine hydrochloride. Her reticulocyte count was low, and a bone marrow aspirate revealed erythroid hypoplasia without involvement of other cell lines. Thus a diagnosis of pure red cell aplasia (PRCA) was made. The anemia gradually resolved following withdrawal of the drug. Although several drugs are known to cause PRCA, this is the first time that clomipramine hydrochloride has been reported to have such an effect. The underlying SLE in this case suggested the possible immunological pathogenesis of drug-induced PRCA.
authors.affiliation: Department of Internal Medicine, Sapporo Central Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Kogawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hirayama
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Nobuoka
authors.forename: K
authors.initials: K
authors.lastname: Kuribayashi
authors.forename: S
authors.initials: S
authors.lastname: Iyama
authors.forename: K
authors.initials: K
authors.lastname: Takada
authors.forename: S
authors.initials: S
authors.lastname: Hagiwara
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: J
authors.initials: J
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Sakamaki
authors.forename: S
authors.initials: S
authors.lastname: Ishigaki
authors.forename: Y
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D002997:Clomipramine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine