title: Flavonoids protect against oxidative damage to LDL in vitro: use in selection of a flavonoid rich diet and relevance to LDL oxidation resistance ex vivo?
abstract: The ability of a range of dietary flavonoids to inhibit low-density lipoprotein (LDL) oxidation in vitro was tested using a number of different methods to assess oxidative damage to LDL. Overall quercetin was the most effective inhibitor of oxidative damage to LDL in vitro. On this basis, a diet enriched with onions and black tea was selected for a dietary intervention study that compared the effect on the Cu2+ ion-stimulated lag-time of LDL oxidation ex vivo in healthy human subjects of a high flavonoid diet compared with a low flavonoid diet. No significant difference was found in the Cu2+ ion-stimulated lag-time of LDL oxidation ex vivo between the high flavonoid and low flavonoid dietary treatments (48 +/- 1.6 min compared to 49 +/- 2.1 min).
authors.affiliation: Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre, King's College London, UK.
authors.forename: J D
authors.initials: JD
authors.lastname: O'Reilly
authors.forename: T A
authors.initials: TA
authors.lastname: Sanders
authors.forename: H
authors.initials: H
authors.lastname: Wiseman
mesh_terms: D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood; D003300:Copper / Q000494:pharmacology; D018592:Cross-Over Studies; D004032:Diet; D005227:Fatty Acids / Q000097:blood; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D019697:Onions; D011794:Quercetin / Q000494:pharmacology; D013662:Tea; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D005227:Fatty Acids; D005419:Flavonoids; D008077:Lipoproteins, LDL; D013662:Tea; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D003300:Copper; D011794:Quercetin