Molluscicidal activity of 2-hydroxy-3-alkyl-1,4-naphthoquinones and derivatives.
In the search for new molluscicidal agents we tested the activity of lapachol and other 2-hydroxy-3-alkylnaphthoquinones possessing nitrogenated alkyl chains, against the snail Biomphalaria glabrata. Lapachol, isolapachol and nor-lapachol showed strong molluscicidal activity against the adult snail (LD(90)<10 ppm) and significant toxicity against snail egg masses (LD(90)<0.2 ppm). As lapachol is easily extracted, and the derivatives can be synthesised without any difficulty, large-scale synthesis and field tests can be conducted, with a view to large-scale molluscicidal programs.
dos Santos
A F
AF
Departamento de Química/CCEN, Universidade Federal de Alagoas, Maceió, Alagoas, 57072-970, Brazil.
Ferraz
P A
PA
Pinto
A V
AV
Pinto M do
C
C
Goulart
M O
MO
Sant'Ana
A E
AE
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001681:Biological Assay; D001938:Brazil; D008975:Molluscacides / Q000494:pharmacology*; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects / Q000254:growth & development*
D000890:Anti-Infective Agents; D008975:Molluscacides; D009285:Naphthoquinones; C008252:lapachol