[Evaluation of major pharmacokinetic parameters of high molecular weight polyethylene oxide using polymer hydrodynamic properties].
The pharmacokinetics of high-molecular-weight polyethylene oxide (HMW PEO)--a parent compound in the polietoks drug--was experimentally studied in cats. A PEO concentration in the blood was determined by measuring a decrease in the hydrodynamic resistance for a blood sample flowing in the turbulent mode via a glass capillary. Variation of the polymer concentration in the blood is described by a single-exponent function with an elimination halftime of T1/2 = 3.15 h. According to the calculation, 99.6% of the initial amount of PEO losses the antiturbulent activity within 24 h.
Chernysheva
G A
GA
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Russia.
Plotnikov
M B
MB
Smol'iakova
V I
VI
Fokin
V A
VA
Nevzorov
M S
MS
D000818:Animals; D001769:Blood; D002415:Cats; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics*; D012212:Rheology
D011092:Polyethylene Glycols