title: Thromboembolic prophylaxis with danaparoïd (Orgaran) in a high-thrombosis-risk pregnant woman with a history of heparin-induced thrombocytopenia (HIT) and Widal's disease.
abstract: There is no consensus concerning thromboembolic prophylaxis in high-risk pregnant women with a previous history of heparin-induced thrombocytopenia. An alternative anticoagulant therapy is danaparoïd, whereas unfractioned and low-molecular-weight heparin therapy is contraindicated. We report a case of successful thrombosis prophylaxis using danaparoïd in a high-thrombosis-risk pregnant woman with a history of heparin-induced thrombocytopenia during a previous pregnancy and Widal's disease.
authors.affiliation: Laboratoire d'Hématologie, CHU de Poitiers, France.
authors.forename: L
authors.initials: L
authors.lastname: Macchi
authors.forename: R
authors.initials: R
authors.lastname: Sarfati
authors.forename: M
authors.initials: M
authors.lastname: Guicheteau
authors.forename: V
authors.initials: V
authors.lastname: Chamlian
authors.forename: O
authors.initials: O
authors.lastname: Pourrat
authors.forename: Y
authors.initials: Y
authors.lastname: Gruel
authors.forename: G
authors.initials: G
authors.lastname: Magnin
authors.forename: A
authors.initials: A
authors.lastname: Brizard
authors.forename: C
authors.initials: C
authors.lastname: Boinot
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced / Q000150:complications; D002511:Cephalosporins / Q000009:adverse effects; D002809:Chondroitin Sulfates / Q000008:administration & dosage*; D003871:Dermatan Sulfate / Q000008:administration & dosage*; D004338:Drug Combinations; D004342:Drug Hypersensitivity; D005260:Female; D006493:Heparin / Q000009:adverse effects; D006496:Heparinoids / Q000008:administration & dosage; D006497:Heparan Sulfate / Q000008:administration & dosage*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000188:drug therapy*; D012307:Risk Factors; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced / Q000150:complications; D013923:Thromboembolism / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants; D001241:Aspirin; D002511:Cephalosporins; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D004338:Drug Combinations; D006493:Heparin; D006496:Heparinoids; D006497:Heparan Sulfate; C035838:danaparoid