title: Muscle fibers in inflammatory myopathies and cultured myoblasts express the nonclassical major histocompatibility antigen HLA-G.
abstract: We demonstrate that HLA-G, a nonclassical major histocompatibility complex class I antigen, is expressed in muscle fibers in various inflammatory myopathies. Further, interferon-gamma induces surface expression and upregulation of mRNA transcripts corresponding to different isoforms of HLA-G in myoblasts cultured from control subjects and patients. HLA-G may have important immunological functions in inflammatory myopathies and other local immune reactions as they occur during vaccination, myoblast transplantation, and gene therapy.
authors.affiliation: Department of Neuroimmunology, Max-Planck-Institute for Neurobiology, Martinsreid, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Wiendl
authors.forename: L
authors.initials: L
authors.lastname: Behrens
authors.forename: S
authors.initials: S
authors.lastname: Maier
authors.forename: M A
authors.initials: MA
authors.lastname: Johnson
authors.forename: E H
authors.initials: EH
authors.lastname: Weiss
authors.forename: R
authors.initials: R
authors.lastname: Hohlfeld
mesh_terms: D002478:Cells, Cultured / Q000276:immunology / Q000473:pathology; D006680:HLA Antigens / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D009132:Muscles / Q000276:immunology / Q000473:pathology*; D009220:Myositis / Q000276:immunology / Q000473:pathology*; D016133:Polymerase Chain Reaction
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I