title: Sialochemical markers of salivary gland involvement with Sjögren's syndrome secondary to rheumatoid arthritis and primary biliary cirrhosis.
abstract: Sjögren's syndrome is an autoimmune condition affecting the lacrimal and salivary glands and can be associated with rheumatoid arthritis and primary biliary cirrhosis. Parotid salivas collected from patients and normal controls were analysed for lactoferrin, IgA and beta2-microglobulin (measured by ELISA), and cystatin (measured by a enzyme inhibition assay). Output data provided less variable means, whilst expressing results as a proportion of the total protein provided greater specificity as markers for Sjögren's syndrome. Levels of specificity for IgA, lactoferrin and beta2-microglobulin were all high (100, 95 and 100%, respectively). Sensitivity levels of these markers (but not cystatin) tended to be similar for Sjögren's syndrome secondary to primary biliary cirrhosis (IgA, 25%; lactoferrin, 63%; and beta2-microglobulin, 50%), compared to Sjögren's syndrome secondary to connective tissue diseases such as rheumatoid arthritis (IgA, 50%; lactoferrin, 86%; and beta2-microglobulin; 38%).
authors.affiliation: Department of Oral Pathology, GKT, King's College Hospital, London, UK.
authors.forename: G H
authors.initials: GH
authors.lastname: Carpenter
authors.forename: G B
authors.initials: GB
authors.lastname: Proctor
authors.forename: C L
authors.initials: CL
authors.lastname: Pankhurst
authors.forename: J
authors.initials: J
authors.lastname: O'Donohue
authors.forename: D
authors.initials: D
authors.lastname: Scott
authors.forename: M P
authors.initials: MP
authors.lastname: Hunnable
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000378:metabolism; D016022:Case-Control Studies; D003240:Connective Tissue Diseases / Q000150:complications / Q000378:metabolism; D015891:Cystatins / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis / Q000378:metabolism; D007781:Lactoferrin / Q000032:analysis / Q000378:metabolism; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000378:metabolism; D010306:Parotid Gland / Q000378:metabolism; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000032:analysis / Q000378:metabolism*; D012636:Secretory Rate; D012859:Sjogren's Syndrome / Q000209:etiology* / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000032:analysis / Q000378:metabolism
chemical_list: D015891:Cystatins; D007071:Immunoglobulin A, Secretory; D012471:Salivary Proteins and Peptides; D001613:beta 2-Microglobulin; D007781:Lactoferrin