Glucagon-producing neuroendocrine tumour associated with hypoaminoacidaemia and skin lesions.
A nine-year-old neutered female crossbred Bernese mountain dog was diagnosed with superficial necrolytic dermatitis and a glucagon-producing islet cell tumour. Laboratory findings included hyperglucagonaemia and hypoaminoacidaemia. The dog was euthanased because of progression of the disease, and necropsy revealed liver metastases of a neuroendocrine carcinoma with immunohistochemical expression of glucagon and somatostatin. This report represents a case of canine glucagonoma syndrome; the previously reported cases in dogs are also briefly described.
Allenspach
K
K
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Zurich, Switzerland.
Arnold
P
P
Glaus
T
T
Hauser
B
B
Wolff
C
C
Eberle
C
C
Komminoth
P
P
D007516:Adenoma, Islet Cell / Q000473:pathology / Q000662:veterinary*; D000596:Amino Acids / Q000097:blood; D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D005934:Glucagon / Q000096:biosynthesis*; D005935:Glucagonoma / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D009336:Necrosis; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000662:veterinary*; D013004:Somatostatin / Q000096:biosynthesis
D000596:Amino Acids; D013004:Somatostatin; D005934:Glucagon