Tolerance of the normal canine brain to epithermal neutron irradiation in the presence of p-boronophenylalanine.
Twelve normal dogs underwent brain irradiation in a mixed-radiation, mainly epithermal neutron field at the Brookhaven Medical Research Reactor following intravenous infusion of 950 mg of 10B-enriched BPA/kg as its fructose complex. The 5 x 10 cm irradiation aperture was centered over the left hemisphere. For a subgroup of dogs reported previously, we now present more detailed analyses including dose-volume relationships, longer follow-ups, MRIs, and histopathological observations. Peak doses (delivered to 1 cm3 of brain at the depth of maximum thermal neutron flux) ranged from 7.6 Gy (photon-equivalent dose: 11.8 Gy-Eq) to 11.6 Gy (17.5 Gy-Eq). The average dose to the brain ranged from 3.0 Gy (4.5 Gy-Eq) to 8.1 Gy (11.9 Gy-Eq) and to the left hemisphere, 6.6 Gy (10.1 Gy-Eq) to 10.0 Gy (15.0 Gy-Eq). Maximum tolerated 'threshold' doses were 6.7 Gy (9.8 Gy-Eq) to the whole brain and 8.2 Gy (12.3 Gy-Eq) to one hemisphere. The threshold peak brain dose was 9.5 Gy (14.3 Gy-Eq). At doses below threshold, some dogs developed subclinical MRI changes. Above threshold, all dogs developed dose-dependent MRI changes, neurological deficits, and focal brain necrosis.
Coderre
J A
JA
Medical Department, Brookhaven National Laboratory, Upton, NY, USA. coderre@bnl.gov
Gavin
P R
PR
Capala
J
J
Ma
R
R
Morris
G M
GM
Button
T M
TM
Aziz
T
T
Peress
N S
NS
D000818:Animals; D001896:Boron Compounds / Q000494:pharmacology*; D016754:Boron Neutron Capture Therapy; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects*; D004285:Dogs; D018655:Lymphocyte Count; D008279:Magnetic Resonance Imaging; D018482:Muscle, Skeletal / Q000528:radiation effects; D009502:Neutrons; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010976:Platelet Count; D011829:Radiation Dosage; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012535:Scalp / Q000528:radiation effects
D001896:Boron Compounds; D011838:Radiation-Sensitizing Agents; D010649:Phenylalanine; C033685:4-boronophenylalanine