Atypical antipsychotic-like effect of AMPA receptor antagonists in the rat.
Systemic administration of two chemically different AMPA receptor antagonists, GYKI52466, 20mg/kg, and LY326325, 18mg/kg, given subcutaneously, caused a selective suppression of conditioned avoidance response in the rat with preservation of escape behavior. The number of intertrial crosses was not affected and no catalepsy was observed. These experimental results indicate, in principle, an antipsychotic effect of AMPA receptor antagonists with a low liability for extrapyramidal side effects and, consequently, a pharmacological profile consonant with atypical antipsychotic drugs.
Svensson
T H
TH
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Mathé
J M
JM
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D001569:Benzodiazepines; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D013777:Tetrazoles / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D007546:Isoquinolines; D018091:Receptors, AMPA; D013777:Tetrazoles; C061950:GYKI 52466; D001569:Benzodiazepines; C082309:tezampanel