title: [Atypical process of acute disturbance of liver function with severe thrombocytopenia in the third trimester].
abstract: The authors diagnosed disturbance of liver-function associated with severe thrombopenia in a pregnant woman in the third trimester. Principally, acute fatty liver of pregnancy can be characterized by existing symptoms, e.g. nausea, vomiting, epigastric pain, jaundice, hyperbilirubinemia, moderately elevated SGOT and SGPT levels, thrombopenia, leukocytosis, low fibrinogen level and disseminated intravascular coagulopathy, but hepatomegaly, purpura and petechia on lower and upper extremities, and high ALP and GGT levels during postpartum period do not confirm suspicion of this diagnosis. The present report draws attention to the difficulties of differential diagnosis of pregnancy-induced elevated liver enzymes diseases associated with low platelets, as there are several identical pathophysiological processes. Although causes and exact pathophysiology of disorders are unknown, similar symptoms during the process of diseases leave the question open whether they are different diseases or whether they are different manifestations of the same disease, and what kind of relationship exists between these diseases and preeclampsia. This case suggests careful evaluation of the whole clinical picture, moreover it is emphasized that prompt, aggressive treatment of hemostatic disturbance and the expeditious delivery can save maternal life.
authors.affiliation: Klinik für Geburtshilfe und Frauenheilkunde, Semmelweis Medizinische Universität, Budapest Ungarn.
authors.forename: J
authors.initials: J
authors.lastname: Rigó
authors.forename: J
authors.initials: J
authors.lastname: Tanyi
authors.forename: I
authors.initials: I
authors.lastname: Varga
authors.forename: E
authors.initials: E
authors.lastname: Görbe
mesh_terms: D000208:Acute Disease; D000328:Adult; D002585:Cesarean Section; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005234:Fatty Liver / Q000175:diagnosis* / Q000201:enzymology; D005260:Female; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007044:Hysterectomy; D007231:Infant, Newborn; D008111:Liver Function Tests; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000209:etiology; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D011693:Purpura / Q000209:etiology; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000209:etiology