title: [Spatial and temporary changes in sensitivity of murine proliferative system and energy exchange to typhoid fever infection].
abstract: The authors studied the spatial and temporary organization of the proliferative system and energy exchange in the small intestinal epithelium, as well as spatial and temporary changes in the sensitivity of these systems in mice to typhoid fever infection (cultured Salmonella typhi, 4446) at day and night. The small intestinal epithelial systems were found to show a spatial and time organization and a close correlation between their temporary and spatial changes after infection. The temporary organization of the proliferative system in the esophageal epithelium is more sensitive to infection in the day-time and that of the small intestinal epithelial proliferative system is more marked at night. Thus, these changes are tissue-specific. Typhoid fever infection causes a negative effect on the proliferative system of the small intestine at night and on its energy exchange in the day-time, which shows the system-specific response of the temporary organization of a biological process within the same organ. The changes in the spatial proliferative and energy exchange parameters in the small intestinal epithelium, which have been caused by the infection of animals, depend on the time of a day.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Romanov
authors.forename: V V
authors.initials: VV
authors.lastname: Markina
authors.forename: A I
authors.initials: AI
authors.lastname: Antokhin
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Popova
authors.forename: O A
authors.initials: OA
authors.lastname: Irikov
authors.forename: S S
authors.initials: SS
authors.lastname: Filippovich
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Sliniakova
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D004195:Disease Models, Animal; D004734:Energy Metabolism / Q000502:physiology*; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*; D007421:Intestine, Small / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D012485:Salmonella typhi / Q000302:isolation & purification; D014435:Typhoid Fever / Q000378:metabolism* / Q000473:pathology*