title: [Sporadic familial meningiomas].
abstract: BACKGROUND
  Meningiomas are primary tumours of the central nervous system. Usually they are sporadic. The occurrence in more than one member of a family is unusual. Up till now this coincidence had been related with type 2 neurofibromatosis. In this paper we comment on two siblings who did not fulfil neurofibromatosis diagnostic criteria as an example of sporadic familial meningiomas.
  
  
  METHODS
  Two siblings (a 79 years old female and a 77 years old male) were diagnosed of a meningioma in an interval of two years, with surprising clinical and neuroimaging similarities. In sporadic meningiomas, abnormalities in the long arm of chromosome 22 have been found. Type 2 neurofibromatosis causative gene has also been found in this chromosome. Meningiomas are quite often found in this entity, and therefore, this gene was implicated as a main factor in the genesis of an important number of meningiomas. However, several studies have not found an association between these tumours and the locus for neurofibromatosis, leading to think that there may be other genes that may influence on meningiomas development.
authors.affiliation: Servicio de Neurología, Hospital General Universitario de Alicante, España. medranovic@gva.es
authors.forename: V
authors.initials: V
authors.lastname: Medrano-Martínez
authors.forename: J M
authors.initials: JM
authors.lastname: Moltó-Jordà
authors.forename: R M
authors.initials: RM
authors.lastname: Sánchez-Pérez
authors.forename: M D
authors.initials: MD
authors.lastname: Castaño-Pérez
authors.forename: J
authors.initials: J
authors.lastname: Arenas
authors.forename: I
authors.initials: I
authors.lastname: Beltrán-Blasco
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D008579:Meningioma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D016518:Neurofibromatosis 2 / Q000175:diagnosis / Q000235:genetics; D014057:Tomography, X-Ray Computed