[ALL complicated by obstructive jaundice due to choledocholithiasis after unrelated bone marrow transplantation].
A 22-year-old man with acute lymphocytic leukemia underwent allogeneic bone marrow transplantation (BMT) from an unrelated donor in October 1996. In April 1997, he suddenly developed severe abdominal pain with nausea and vomiting. The diagnosis was obstructive jaundice associated with gallstones in the gallbladder and common bile duct. The patient underwent laparoscopic cholecystectomy and endoscopic removal of the stones in the common bile duct. The major component of the gallstones was bilirubinate calcium. Although the pathogenesis of gallstones after BMT remains unclear, several factors including impaired contractility of the gallbladder, hemolysis, changes in bile composition, and biliary tract infection may play important roles.
Andoh
A
A
Department of Internal Medicine, Shiga University of Medical Science.
Hodohara
K
K
Inoue
T
T
Kitoh
K
K
Fujiyama
Y
Y
Bamba
T
T
D000328:Adult; D016026:Bone Marrow Transplantation; D002779:Cholestasis / Q000150:complications*; D042882:Gallstones / Q000150:complications*; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014184:Transplantation, Homologous