Immunophenotypical characterization of the lymphocyte infiltrate in caprine pulmonary tuberculosis.
A study was made of the immunophenotype of the lymphocytes associated with natural caprine pulmonary tuberculosis at four stages of the disease. Regardless of the stage, CD4(+)and CD8(+)T lymphocytes predominated in lung and mediastinal lymph node lesions, but gamma/delta T and B (IgM(+)) cells were seen only rarely. At the primary complex stage, CD4(+)cells outnumbered CD8(+)cells. At the stage of generalized tuberculosis, however, and still more at the post-primary stage, CD8(+)cells outnumbered CD4(+)cells. At the final stage (tuberculous pneumonia), CD4(+)and CD8(+)cells were present in low but approximately equal numbers.
Seva
J
J
U.D. Histología y Anatomía Patológica, Facultad de Veterinaria, Universidad de Murcia, Apdo. Correos 4021, Murcia, 30071, Spain.
Hernández
D
D
Bernabé
A
A
Pallarés
F J
FJ
Navarro
J A
JA
D000818:Animals; D015704:CD4 Antigens / Q000032:analysis; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens / Q000032:analysis; D015511:Goat Diseases / Q000276:immunology* / Q000473:pathology; D006041:Goats; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008168:Lung / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology* / Q000473:pathology / Q000662:veterinary
D015704:CD4 Antigens; D016827:CD8 Antigens