Mass spectrometry and proteomics.
Proteomics is the systematic analysis of the proteins expressed by a cell or tissue, and mass spectrometry is its essential analytical tool. In the past two years, incremental advances in standard proteome technology have increased the speed of protein identification with higher levels of automation and sensitivity. Furthermore, new approaches have provided landmark advances in determining functionally relevant properties of proteins, including their quantity and involvement within protein complexes.
Gygi
S P
SP
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Aebersold
R
R
D013058:Mass Spectrometry / Q000379:methods*; D020543:Proteome
D020543:Proteome