title: Central serous retinopathy complicating systemic lupus erythematosus: a case series.
abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with widespread manifestations including the eye. Central serous retinopathy (CSR) has been associated as a complicating event in SLE, although it is uncommon. We present a case series of four female Chinese SLE patients who developed CSR during the course of their systemic disease. All four presented clinically with typical CSR. Angiographic findings did not show evidence of choroidal ischaemia or delayed choroidal filling. Resolution of the serous retinal detachment occurred in all four patients. Recovery of vision was seen in three patients. The clinical outcome was similar to that occurring in the usual male population. Central serous retinopathy as a manifestation of SLE may be caused by various factors. These include SLE-associated choroidopathy, systemic hypertension, renal disease, retinal pigment epithelial dysfunction and glucocorticoid therapy.
authors.affiliation: Singapore National Eye Centre, Tan Tock Seng Hospital, Singapore. cgkhng@pacific.net.sg
authors.forename: C G
authors.initials: CG
authors.lastname: Khng
authors.forename: E Y
authors.initials: EY
authors.lastname: Yap
authors.forename: K G
authors.initials: KG
authors.lastname: Au-Eong
authors.forename: T H
authors.initials: TH
authors.lastname: Lim
authors.forename: K H
authors.initials: KH
authors.lastname: Leong
mesh_terms: D000328:Adult; D002199:Capillary Permeability; D002829:Choroid / Q000098:blood supply; D015862:Choroid Diseases / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005122:Exudates and Transudates; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007511:Ischemia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D012163:Retinal Detachment / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D015861:Retinal Neovascularization / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids