Antisense therapy in cancer.
This review discusses laboratory and clinical studies of antisense oligodeoxynucleotides as potential treatments for haematological malignancies and solid tumours. Mechanisms of action, pharmacokinetics, toxicities and potential clinical applications of these agents are described.
Pawlak
W
W
Department of Oncology, Central Clinical Hospital of Military Medical Academy, Warsaw, Poland.
Zolnierek
J
J
Sarosiek
T
T
Szczylik
C
C
D017209:Apoptosis; D001692:Biological Transport; D018432:Drug Resistance, Multiple; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D016376:Oligonucleotides, Antisense / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D009857:Oncogenes / Q000235:genetics
D016376:Oligonucleotides, Antisense