Age-related changes in activation of telomerase in the bone marrow of normal and thymectomized mice.
Age-related and thymus-dependent regulation of telomerase activity was studied in the bone marrow of normal (physiological aging) and thymectomized (experimental aging) mice. There was no strong correlation between the age and telomerase activity in bone marrow cells of normal mice. We observed only small individual differences in telomerase activity. Thymectomy 2-fold increased telomerase expression in young (2-month-old) and old (24-month-old) animals. Individual differences in telomerase activity in the bone marrow of thymectomized mice were more pronounced and did not depend on the age. The role of the thymus in cell aging is discussed.
Todriya
T V
TV
Hematological Research Center, Moscow. todria@blood.ru
Grimm
Y
Y
Tsander
A
A
D000375:Aging; D000818:Animals; D001854:Bone Marrow Cells / Q000201:enzymology*; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D019098:Telomerase / Q000378:metabolism*; D013934:Thymectomy
D019098:Telomerase