title: [Intercellular integration in the central nervous system].
abstract: A humoral mechanism of the intercellular communication in the CNS based on diffusion of neuroactive compounds within the brain extracellular space, was studied. The leading role of the volume transmission was shown in the early stage of ontogeny. Structural basis of this mechanism was studied in adult mammals, and the data on extrasynaptic receptors and release of classical neurotransmitters into the extracellular space was reviewed.
authors.affiliation: Institute of Experimental Medicine of the Russian Acad. Med. Sci., St. Petersburg, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Otellin
authors.forename: N B
authors.initials: NB
authors.lastname: Saul'skaia
mesh_terms: D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000196:embryology / Q000378:metabolism* / Q000648:ultrastructure; D004058:Diffusion; D004298:Dopamine / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013569:Synapses / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid; D004298:Dopamine