Preparation of cross-linked sodium alginate microparticles using glutaraldehyde in methanol.
Polymeric sodium alginate microparticles were prepared by precipitating sodium alginate in methanol, followed by cross-linking with glutaraldehyde. The extent of cross-linking was controlled by the time of exposure to glutaraldehyde. The topology of microparticles was characterized by scanning electron microscopy (SEM), which indicated smooth surfaces. The equilibrium swelling experiments were carried out in water to observe the effect of cross-linking and drug loading for better utility of microparticles. It was found that swelling decreased, but drug loading increased, with an increase in cross-linking of the matrix.
Kulkarni
A R
AR
Department of Chemistry, Karnatak University, Dharwad, India.
Soppimath
K S
KS
Aralaguppi
M I
MI
Aminabhavi
T M
TM
Rudzinski
W E
WE
D000464:Alginates / Q000737:chemistry / Q000493:pharmacokinetics*; D001672:Biocompatible Materials / Q000737:chemistry / Q000493:pharmacokinetics*; D003432:Cross-Linking Reagents; D020723:Glucuronic Acid; D005976:Glutaral / Q000737:chemistry; D006603:Hexuronic Acids; D000432:Methanol / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011108:Polymers
D000464:Alginates; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D006603:Hexuronic Acids; D011108:Polymers; D020723:Glucuronic Acid; D005976:Glutaral; D000432:Methanol