Recommendations for the categorization of germ cell mutagens.
Germ cell mutagens are currently classified into three categories in the German List of MAK and BAT Values. These categories have been revised and extended by analogy with the new categories for carcinogenic chemicals. Germ cell mutagens produce heritable gene mutations, and heritable structural and numerical chromosome aberrations in germ cells. The original categories 1 and 2 for germ cell mutagens remain unchanged. Two new categories 3A and 3B are proposed for chemicals suspected to be germ cell mutagens. A new category 5 is proposed for germ cell mutagens with low potency that contribute negligibly to human genetic risk provided the MAK value is observed.
Adler
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ID
GSF--National Research Center for Environment and Health, Institute of Experimental Genetics, Neuherberg, Germany. adler@gsf.de
Andrae
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U
Kreis
P
P
Neumann
H G
HG
Thier
R
R
Wild
D
D
D005854:Germ Cells / Q000187:drug effects*; D018095:Germ-Line Mutation / Q000187:drug effects*; D006801:Humans; D009153:Mutagens / Q000009:adverse effects / Q000145:classification*; D012307:Risk Factors
D009153:Mutagens