title: Proposal of a standard approach to dental extraction in haemophilia patients. A case-control study with good results.
abstract: We found no case-control studies on dental extraction in haemophilia patients in the literature even though the use of antifibrinolytic agents following a single infusion of factor VIII or IX has been accompanied by a lower number of bleeding complications in dental extractions. In this study we verified the incidence of bleeding complications after dental extraction in a group of 77 haemophilia patients. One hundred and eighty-four male patients requiring dental extraction represented the control group. All haemophilia patients received 20 mg kg-1 of tranexamic acid and a single infusion of factor VIII or IX to achieve a peak level about 30% of factor VIII or IX in vivo prior to dental extraction. Forty-five of 98 (45.9%) dental extractions in haemophilia patients and 110 of 239 (46%) dental extractions in the control group were surgical ones. We registered two bleeding complications in the group of haemophilia patients (one late bleeding and one haematoma in the site of the anaesthetic injection) and one (a late bleeding) in the control group. The difference of bleeding complications in the two groups of patients were not statistically significant (P=0.2; OR 0.2; CI 0.01-2.22). The protocol proposed in this study, characterized by the feasibility and the number of haemorrhagic complications not different from normal population, make dental extractions in haemophilia patients possible on an out-patient basis with a cost reduction for the community and minor discomfort for the patients.
authors.affiliation: Department of Medical and Surgical Sciences, University of Padua Medical School, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Zanon
authors.forename: F
authors.initials: F
authors.lastname: Martinelli
authors.forename: C
authors.initials: C
authors.lastname: Bacci
authors.forename: P
authors.initials: P
authors.lastname: Zerbinati
authors.forename: A
authors.initials: A
authors.lastname: Girolami
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D017742:Dental Care for Chronically Ill / Q000009:adverse effects / Q000379:methods / Q000592:standards; D005164:Factor IX / Q000008:administration & dosage; D005169:Factor VIII / Q000008:administration & dosage; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D006472:Oral Hemorrhage / Q000209:etiology / Q000517:prevention & control; D014081:Tooth Extraction / Q000009:adverse effects / Q000379:methods* / Q000592:standards
chemical_list: D005169:Factor VIII; D005164:Factor IX