title: Bipolar disorder: can studies of natural history help us define clinically and neurobiologically relevant subtypes?
authors.forename: D S
authors.initials: DS
authors.lastname: Charney
mesh_terms: D017668:Age of Onset; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology; D001714:Bipolar Disorder / Q000145:classification* / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D015897:Comorbidity; D019955:Conduct Disorder / Q000453:epidemiology; D018450:Disease Progression; D006801:Humans; D008137:Longitudinal Studies; D008959:Models, Neurological; D019966:Substance-Related Disorders / Q000453:epidemiology; D014481:United States / Q000453:epidemiology