title: Reversible bull's-eye maculopathy associated with intravitreal fomivirsen therapy for cytomegalovirus retinitis.
abstract: OBJECTIVE
  To report two cases in which a bull's eye maculopathy developed after intravitreal injection of fomivirsen.
  
  
  METHODS
  Case reports.
  
  
  RESULTS
  A 50-year-old man with acquired immunodeficiency syndrome (AIDS) and refractory cytomegalovirus retinitis developed bull's-eye pigmentary changes in the macula of the right eye after initiating therapy with fomivirsen (Vitravene; CIBA Vision, Atlanta, Georgia) intravitreal injections. These pigmentary changes resolved upon cessation of treatment. A 36-year-old man with AIDS and refractory bilateral cytomegalovirus retinitis developed bull's-eye pigmentary changes in both eyes during bilateral intravitreal treatment with fomivirsen. Vision was not affected. These changes resolved after treatment with fomivirsen was stopped.
  
  
  CONCLUSIONS
  Fomivirsen, a new medication for the treatment of refractory cytomegalovirus retinitis, may cause a bull's-eye maculopathy in some patients. The bull's-eye maculopathy is reversible and does not appear to affect vision.
authors.affiliation: Duke University Eye Center, Durham, North Carolina 27710, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Stone
authors.forename: G J
authors.initials: GJ
authors.lastname: Jaffe
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008266:Macula Lutea / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000139:chemically induced* / Q000503:physiopathology; D013873:Thionucleotides / Q000009:adverse effects* / Q000627:therapeutic use; D014792:Visual Acuity; D014822:Vitreous Body
chemical_list: D000998:Antiviral Agents; D013873:Thionucleotides; C091346:fomivirsen