Synthesis of a primary metabolite of cannabidiol.
Cannabidiol 1 is the major nonpsychotropic, neutral constituent in most cannabis preparations. It is devoid of the psychoactive properties typical of cannabis; however, it produces numerous, potentially therapeutic pharmacological effects, some of which may be due to its metabolites. We report now the first total synthesis of 7-hydroxycannabidiol 2, a primary metabolite of cannabidiol, in an eight-step procedure.
Tchilibon
S
S
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University Medical Faculty, Jerusalem 91120, Israel.
Mechoulam
R
R
D002185:Cannabidiol / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
D002185:Cannabidiol