title: A case of idiopathic constrictive bronchiolitis in a middle-aged male smoker.
abstract: When one sees a middle-aged male smoker who presents with progressive exertional dyspnoea and irreversible airflow obstruction, the most likely clinical diagnosis is pulmonary emphysema or chronic obstructive pulmonary disease (COPD). We report a 45-year-old male smoker who was initially suspected to have such a disease but was eventually diagnosed as having idiopathic constrictive bronchiolitis by lung biopsy, clinical history, and laboratory findings. A finding on lung computed tomography of diffuse hyperinflation but few low attenuation areas and relatively well-preserved diffusing capacity of carbon monoxide seems to be the key for suspecting this rare clinical entity. The pathological difference between this bronchiolitis and small airway disease observed in COPD will be also discussed.
authors.affiliation: First Department of Medicine, Hokkaido University, School of Medicine, Sapporo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Tsujino
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Ohira
authors.forename: H
authors.initials: H
authors.lastname: Yoshimura
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakami
mesh_terms: D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D001988:Bronchiolitis / Q000175:diagnosis* / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D011656:Pulmonary Emphysema / Q000175:diagnosis; D012907:Smoking; D014057:Tomography, X-Ray Computed