title: Successful zonisamide treatment for infants with hypsarrhythmia.
abstract: We determined that zonisamide was effective in three epileptic infants with hypsarrhythmia. Two patients had the electroencephalographic pattern of hypsarrhythmia associated with developmental delay but lacked the characteristic tonic spasms. A third patient exhibited the typical triad of infantile spasms but had a poor general condition requiring controlled ventilation. We therefore chose zonisamide instead of adrenocorticotropin for these patients. Our data suggest that zonisamide may be a useful treatment in patients falling short of the diagnostic triad of infantile spasms or complicated by a poor overall medical condition.
authors.affiliation: Department of Pediatrics, Hiroshima Memorial Hospital, Hiroshima, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kishi
authors.forename: Y
authors.initials: Y
authors.lastname: Nejihashi
authors.forename: M
authors.initials: M
authors.lastname: Kajiyama
authors.forename: K
authors.initials: K
authors.lastname: Ueda
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D002540:Cerebral Cortex / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D007223:Infant; D007555:Isoxazoles / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D013036:Spasms, Infantile / Q000188:drug therapy*; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide