Venous thrombo-embolism following inferior petrosal sinus sampling in Cushing's disease.
Bilateral inferior petrosal sinus sampling for ACTH with corticotrophin releasing hormone stimulation has become an established test in differentiating pituitary Cushing's disease from Cushing's syndrome due to ectopic ACTH secretion. We report two patients with Cushing's disease who developed thromboembolic complications soon after inferior petrosal sinus sampling. We discuss the possible mechanisms leading to this complication in a syndrome in which thromboembolic complications are well recognized and highlight the need for consideration of prophylactic anticoagulation.
Obuobie
K
K
Department of Medicine, University of Wales College of Medicine, Cardiff, UK.
Davies
J S
JS
Ogunko
A
A
Scanlon
M F
MF
D000236:Adenoma / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D005268:Femoral Vein; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D017591:Petrosal Sinus Sampling / Q000009:adverse effects*; D010911:Pituitary Neoplasms / Q000601:surgery; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000209:etiology*; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D014859:Warfarin; D000324:Adrenocorticotropic Hormone; D006493:Heparin; D006854:Hydrocortisone