[Weekly chemotherapy with alternating low-dose CPT-11 and low-dose FP against a far advanced pancreatic cancer--a case report].
We attempted a new regimen of weekly chemotherapy with alternating low-dose CPT-11 and low-dose FP against a case of far advanced pancreatic cancer with invasion to the super mesentric artery, celiac artery, and left renal vein. CPT-11 was administered at 25 mg/m2/day x 3/week, and CDDP and 5-FU were administered at 7 mg and 350 mg/m2/day x 3/week by intravenous infusion. These regimens were alternated every week. The serum CA19-9 level decreased gradually with a half time of approximately 2 months (from 972 to 126 U/ml). The tumor was reduced more than 50% 4 months after chemotherapy, and continuing decreasing for more than 6 months. There were no adverse effects except mild leukopenia (less than Grade 1). These results suggest that the combination of low-dose chemotherapy with fewer side effects may be effective not only for tumor shrinkage, but also for a prolonged time to progression.
Takahashi
Y
Y
Dept. of Surgical Oncology, Kanazawa University.
Kitagata
S
S
Mai
M
M
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D008297:Male; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002945:Cisplatin; D005472:Fluorouracil; D002166:Camptothecin