title: Monoclonal immunoglobulin G cryoglobulinemia and multiple myeloma in a domestic shorthair cat.
abstract: A 13-year-old castrated domestic shorthair cat was examined because of fever, anorexia, and dermatologic lesions. Crusting, erythema, and well-demarcated purple discoloration of the foot pads and the tips of the pinnae, nose, and tail were seen. A white flocculent precipitate was detected in cooled serum. This precipitate dissolved upon rewarming, consistent with a cryoglobulin. Hypercalcemia, high alanine and aspartate aminotransferase activities, thrombocytopenia, and a monoclonal IgG gammopathy were found. Numerous hepatic nodules were detected by means of abdominal ultrasonography. Cytologic evaluation of fine-needle aspirates of the liver and spleen revealed numerous plasma cells, and evaluation of a bone marrow aspirate revealed plasmacytosis. A diagnosis of multiple myeloma and monoclonal IgG cryoglobulinemia was made, and the cat was euthanatized.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA.
authors.forename: F H
authors.initials: FH
authors.lastname: Hickford
authors.forename: T
authors.initials: T
authors.lastname: Stokol
authors.forename: Y A
authors.initials: YA
authors.lastname: vanGessel
authors.forename: J F
authors.initials: JF
authors.lastname: Randolph
authors.forename: T
authors.initials: T
authors.lastname: Schermerhorn
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002371:Cat Diseases / Q000097:blood / Q000276:immunology / Q000473:pathology*; D002415:Cats; D003449:Cryoglobulinemia / Q000150:complications / Q000662:veterinary*; D017809:Fatal Outcome; D007074:Immunoglobulin G; D008099:Liver / Q000473:pathology; D009101:Multiple Myeloma / Q000150:complications / Q000662:veterinary*; D010314:Partial Thromboplastin Time / Q000662:veterinary
chemical_list: D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G