title: Interventricular methotrexate therapy for carcinomatous meningitis due to breast cancer: a case with leukoencephalopathy.
abstract: A 46-year-old woman presented with paraplegia and severe lumbago. She had had a radical mastectomy for left breast cancer 10 years earlier, and 6 months prior to presentation she completed CMF chemotherapy for treatment of retroperitoneal metastasis. CT and MRI to identify potential causes of the paraplegia and lumbago showed leptomeningeal carcinomatosis due to dissemination from invasive recurrence of the retroperitoneal tumor. An Ommaya reservoir was inserted, and infusion of intrathecal methotrexate (MTX; 5 mg twice weekly) began. Her clinical symptoms improved after receiving 53 mg MTX. However, after receiving 83 mg MTX, the patient became dizzy from leukoencephalopathy. Although administration of prednisolone mostly resolved her symptom, the patient died 9 months after the diagnosis of carcinomatous meningitis.
authors.affiliation: Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.forename: A
authors.initials: A
authors.lastname: Igarashi
authors.forename: Y
authors.initials: Y
authors.lastname: Yano
authors.forename: T
authors.initials: T
authors.lastname: Yashiro
authors.forename: E
authors.initials: E
authors.lastname: Ueno
authors.forename: Y
authors.initials: Y
authors.lastname: Aiyoshi
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001706:Biopsy; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D004684:Leukoencephalitis, Acute Hemorrhagic / Q000139:chemically induced* / Q000175:diagnosis; D017116:Low Back Pain / Q000209:etiology; D008279:Magnetic Resonance Imaging; D015409:Mastectomy, Radical; D008577:Meningeal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000556:secondary*; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate