Corticosteroid actions in hippocampus require DNA binding of glucocorticoid receptor homodimers.
Glucocorticoids are secreted from the adrenal gland in very high amounts after stress. In the brain, these stress hormones potently modulate ionic currents, monoaminergic transmission, synaptic plasticity and cellular viability, most notably in the hippocampus where corticosteroid receptors are highly enriched. Here we show that at least some of these actions require DNA binding of glucocorticoid receptor (GR) homodimers.
Karst
H
H
Inst. Neurobiology, University of Amsterdam, Kruislaan 320, 1098 SM Amsterdam, The Netherlands.
Karten
Y J
YJ
Reichardt
H M
HM
de Kloet
E R
ER
Schütz
G
G
Joëls
M
M
D000305:Adrenal Cortex Hormones / Q000819:agonists / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites / Q000187:drug effects* / Q000502:physiology; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D046508:Culture Techniques; D004247:DNA / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D016297:Mutagenesis, Site-Directed / Q000502:physiology; D017966:Pyramidal Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology; D013312:Stress, Physiological / Q000473:pathology / Q000503:physiopathology
D000305:Adrenal Cortex Hormones; D015220:Calcium Channels; D011965:Receptors, Glucocorticoid; D012701:Serotonin; D004247:DNA