Gastric adenocarcinoma in a patient with X-linked agammaglobulinaemia.
Patients with primary immunodeficiencies are at high risk for developing haematological malignancies and, to a lesser degree, carcinoma. We report a patient with ascertained X-linked agammaglobulinaemia who developed a gastric carcinoma involving the distal part of the stomach associated with chronic atrophic gastritis and intestinal metaplasia. These latter conditions are considered to be precursor conditions and the role of chronic infections is likely. Patients with X-linked agammaglobulinaemia, as with other primary immunodeficiencies, could benefit from regular gastrointestinal evaluation, leading to early diagnosis and treatment of carcinoma.
Bachmeyer
C
C
Département de Médecine Interne and Service d'Anatomo-Pathologie, Hôpital Laënnec, Creil, France.
Monge
M
M
Cazier
A
A
Le Deist
F
F
de Saint Basile
G
G
Durandy
A
A
Fischer
A
A
Mougeot-Martin
M
M
D000230:Adenocarcinoma / Q000209:etiology*; D000293:Adolescent; D000361:Agammaglobulinemia / Q000150:complications* / Q000235:genetics; D017809:Fatal Outcome; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010534:Peritoneal Neoplasms / Q000556:secondary; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology*; D014960:X Chromosome