An Epstein-Barr virus-associated pulmonary lymphoproliferative disorder as complication of immunosuppression.
Inherited or acquired immunodeficiencies as well as autoimmune diseases treated with cytotoxic drugs are associated with an increased incidence of lymphoma. Non-Hodgkin's lymphomas that occur in the context of drug-induced immunosuppression, acquired or congenital immunodeficiency, are frequently associated with Epstein-Barr virus infection. This report describes the occurrence of an Epstein-Barr virus associated pulmonary B cell lymphoma in a patient with longstanding rheumatoid arthritis treated with methotrexate.
Van Haarlem
S W
SW
Department of Pulmonology, St. Antonius Hospital Nieuwegein, Postbus 2500, 3430 EM Nieuwegein, The Netherlands.
Verpalen
M C
MC
Van Gorp
J M
JM
Hoekstra
J B
JB
Van Den Bosch
J M
JM
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001707:Biopsy, Needle; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000821:virology*; D008297:Male; D008727:Methotrexate / Q000009:adverse effects*; D008875:Middle Aged; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
D007166:Immunosuppressive Agents; D008727:Methotrexate