title: Suppression of experimental allergic encephalomyelitis is specific to the frequency and intensity of nocturnally applied, intermittent magnetic fields in rats.
abstract: Female Lewis rats (n=72) were inoculated with an emulsion of spinal cord and complete Freund's adjuvant. They were then exposed for approximately 6 min every hour between midnight and 08:00 h for 2 weeks to either 7 or 40 Hz amplitude-modulated magnetic fields whose temporal pattern was designed to simulate a (geomagnetic) storm sudden commencement. The peak strengths of the fields averaged between either 30-50 nT (low intensity) or 500 nT (high intensity). Rats exposed to the 7 Hz, low intensity magnetic fields displayed significantly less severe overt signs of experimental allergic encephalomyelitis than rats exposed to either of the two intensities of the 40 Hz fields, the high intensity 7 Hz field, or the reference (<10 nT) condition. The latter groups did not differ significantly from each other. Predicted severity based upon the numbers of foci of infiltrations of lymphocytes within the brains of the rats also demonstrated the ameliorating effects of the low intensity, 7 Hz exposures. These results suggest very specific characteristics of complex, weak magnetic fields within the sleeping environment could affect the symptoms of autoimmunity.
authors.affiliation: Behavioral Neuroscience Laboratory and Department of Biology Laurentian University, Sudbury, P3E 2C6, Ontario, Canada.
authors.forename: L L
authors.initials: LL
authors.lastname: Cook
authors.forename: M A
authors.initials: MA
authors.lastname: Persinger
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology / Q000473:pathology / Q000528:radiation effects*; D002940:Circadian Rhythm; D003624:Darkness; D004307:Dose-Response Relationship, Radiation; D004574:Electromagnetic Fields; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D005260:Female; D005620:Freund's Adjuvant / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D012720:Severity of Illness Index; D013116:Spinal Cord / Q000276:immunology
chemical_list: D005620:Freund's Adjuvant