title: Curative treatment of cerebral arteriovenous malformations by embolisation using cellulose acetate polymer followed by surgical resection.
abstract: OBJECTIVE
  To investigate the usefulness of embolising cerebral arteriovenous malformations (AVMs) with a cellulose acetate polymer solution before surgical resection.
  
  
  METHODS
  The cases of 12 patients with AVMs treated by embolisation before surgical resection were renewed. Two types of cellulose acetate polymer solutions were used to occlude 40 feeding vessels. All patients underwent surgical resection 1-51 days after embolisation.
  
  
  RESULTS
  Reduction of the nidus volume after embolisation ranged from 20% to nearly 100%. Transient neurological deficits occurred in three patients, persistent deficits occurred in one and there were no haemorrhagic complications. All but one arteriovenous malformation were completely resected. Embolisation helped to identify feeding vessels and ease dissection. Histopathological examination of resected specimens disclosed mild inflammatory reactions in the acute stage and no unfavourable granulomatous changes in the chronic stage.
  
  
  CONCLUSIONS
  Embolisation with cellulose acetate polymer solutions followed by surgical resection is safe and efficacious for treating cerebral AVMs.
authors.affiliation: Department of Neurological Surgery, Okayama University Medical School, Okayama, JApan. kojitoku@med.okayama-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Tokunaga
authors.forename: K
authors.initials: K
authors.lastname: Kinugasa
authors.forename: T
authors.initials: T
authors.lastname: Meguro
authors.forename: K
authors.initials: K
authors.lastname: Sugiu
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: S
authors.initials: S
authors.lastname: Mandai
authors.forename: T
authors.initials: T
authors.lastname: Ohmoto
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000627:therapeutic use*; D002482:Cellulose / Q000031:analogs & derivatives / Q000627:therapeutic use*; D002648:Child; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011108:Polymers / Q000627:therapeutic use*; D014656:Vascular Surgical Procedures
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; C005062:acetylcellulose; D002482:Cellulose