title: Megakaryocyte and platelet structure in thrombocytopoiesis: the effect of cytokines.
abstract: This paper presents an overview of selected data which the author considers crucial to an understanding of structure/function relationships of megakaryocytes (MK) and platelets. The observation that platelet territories form within the MK cytoplasm and that, therefore, MK and platelet plasma membranes need not be structurally or antigenically identical is substantiated on the basis of results obtained with a variety of experiments. While the predominant site of MK fragmentation is still debated, it is generally accepted that such terms as "proplatelets," "giant platelets" or "megathrombocytes" refer to MK fragments consisting of more than one platelet territory. It is suggested that such fragments be called "compound" platelets to convey a unifying concept. The terms "young" or "immature" could be reserved for platelets which still contain ribosomes, rough endoplasmic reticulum or other organelles not usually seen in circulating platelets. Finally, the structure changes induced by cytokines, such as interleukin 3 (IL-3), IL-6, IL-11 and thrombopoietin have been illustrated.
authors.affiliation: Department of Medicine, New York University Medical Center, New York 10016, USA.
authors.forename: D
authors.initials: D
authors.lastname: Zucker-Franklin
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism* / Q000502:physiology* / Q000648:ultrastructure; D001854:Bone Marrow Cells / Q000473:pathology; D019070:Cell Lineage; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D016207:Cytokines / Q000494:pharmacology*; D003593:Cytoplasm / Q000378:metabolism; D005312:Fetal Blood / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D017370:Interleukin-11 / Q000494:pharmacology; D007377:Interleukin-3 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D008253:Macaca mulatta; D008533:Megakaryocytes / Q000378:metabolism* / Q000502:physiology* / Q000648:ultrastructure; D051379:Mice; D051381:Rats; D013926:Thrombopoietin / Q000494:pharmacology
chemical_list: D016207:Cytokines; D017370:Interleukin-11; D007377:Interleukin-3; D015850:Interleukin-6; D013926:Thrombopoietin