Dopamine D4 receptor gene polymorphism and personality traits in healthy volunteers.
An association between long alleles of a variable number tandem repeat (VNTR) polymorphism in the dopamine receptor D4 gene and the extraversion related personality traits Excitement and Novelty Seeking has been reported in healthy subjects. In an attempt to replicate the previous findings, 256 healthy Caucasian volunteers were analysed for a potential relationship between the dopamine receptor D4 exon III VNTR polymorphism and Extraversion as assessed by the Revised Neo Personality Inventory (NEO PI-R). The present study did not yield evidence for an association between Extraversion and the dopamine receptor D4 polymorphism.
Persson
M L
ML
National Institute for Psychosocial Factors and Health and Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden. Maj-Liz.Persson@neurotec.ki.se
Wasserman
D
D
Geijer
T
T
Frisch
A
A
Rockah
R
R
Michaelovsky
E
E
Apter
A
A
Weizman
A
A
Jönsson
E G
EG
Bergman
H
H
D000328:Adult; D000367:Age Factors; D000483:Alleles; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D010551:Personality / Q000235:genetics*; D010552:Personality Assessment; D011110:Polymorphism, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4
C493599:DRD4 protein, human; D005819:Genetic Markers; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4