title: Does histological incomplete excision of cervical intraepithelial neoplasia following large loop excision of transformation zone increase recurrence rates? A six year cytological follow up.
abstract: OBJECTIVE
  To determine the risk of recurrent cervical intraepithelial neoplasia (CIN) in women with complete or incomplete excision of cervical intraepithelial neoplasia treated by large loop excision of transformation zone (LLETZ).
  
  
  METHODS
  A retrospective study
  
  
  METHODS
  One consultant-led colposcopy clinic at Leicester Royal Infirmary
  
  
  METHODS
  Three hundred and ninety-four women referred consecutively to the colposcopy clinic between 1991 and 1992.
  
  
  METHODS
  The histological recurrence rate of CIN, length of cytological follow up following treatment related to degree of completeness of excision at initial treatment.
  
  
  RESULTS
  Three hundred and twenty-two women had complete cytological or histological follow up. The mean length of follow up was 73 months with a mean number of six smears. Women with incomplete excision of CIN had a significantly higher risk of recurrent CIN (relative risk 8.23) occurring in a significantly shorter time compared with women with complete excision.
  
  
  CONCLUSIONS
  This study demonstrates that large loop excision of transformation zone is successful in over 95% of cases. Cytological surveillance is satisfactory for follow up of women who have complete excision of CIN. Women with incomplete excision of CIN at initial LLETZ remain at significant risk of developing further CIN and long term colposcopic and cytological follow up is necessary.
authors.affiliation: Department of Gynaecology, Leicester Royal Infirmary, UK.
authors.forename: S P
authors.initials: SP
authors.lastname: Dobbs
authors.forename: T
authors.initials: T
authors.lastname: Asmussen
authors.forename: D
authors.initials: D
authors.lastname: Nunns
authors.forename: J
authors.initials: J
authors.lastname: Hollingworth
authors.forename: L J
authors.initials: LJ
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Ireland
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D018365:Neoplasm, Residual; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*