title: [Microcirculatory and hemostatic disturbances in patients with influenza and respiratory infections aggravated with coexisting diseases].
abstract: Microcirculatory disorders (MD) and hemostasis (HS) were studied in patients with influenza and acute respiratory viral infection (ARVI). The patients also suffered from ischemic heart disease (IHD), essential hypertension (EH) and diabetes mellitus (DM). Among 241 patients 63.9% were middle-aged and old. 45 patients under 60 years of age without coexisting diseases served control. In acute influenza and ARVI the majority of the postcapillary veins and capillaries were affected with sludge syndrome, there were marked perivascular and vascular changes. Convalescence was accompanied with reduced permeability and intravascular aggregation of erythrocytes, microvessels improved tonicity. HS responded to the acute infections with depression of fibrinolysis, in convalescence platelet aggregation activated. IHD patients had disseminated intravascular red cell aggregation, slowing of the microflow, hypercoagulation. Patients with postmyocardial infarction cardiosclerosis (PIC) had more severe affection of microcirculation and hemostasis in convalescence. In hypertensive patients microcirculation and hemostasis were similar to those with IHD. In diabetics platelet aggregation improved but sludge phenomenon and slow blood flow persisted. Thus, ARVI for IHD, EH DM patients are a risk factor for the disease aggravation. In influenza and ARVI, IHD patients, especially with PIC and EH are contraindicated active physical exercise, intake of dysaggregant drugs is desirable. Diabetics should take drugs improving blood rheology early in acute period of ARVI.
authors.forename: B P
authors.initials: BP
authors.lastname: Bogomolov
authors.forename: A V
authors.initials: AV
authors.lastname: Deviatkin
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005123:Eye / Q000098:blood supply; D005260:Female; D006331:Heart Diseases / Q000150:complications*; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D007251:Influenza, Human / Q000097:blood / Q000150:complications / Q000503:physiopathology; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000097:blood / Q000150:complications / Q000503:physiopathology