A synthetic transmembrane polyether model active in lipid bilayers.
A model polyether-based ion channel-like compound was rationally designed and synthesized. Macromolecules 1c-f were incorporated into phospholipid vesicles and shown to facilitate the transmembrane sodium transport.
Espínola
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CG
Instituto de Investigaciones Químicas, CSIC, Américo Vespucio, s/n, Isla de la Cartuja, 41092 Seville, Spain.
Pérez
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Martín
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JD
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D008567:Membranes, Artificial; D008958:Models, Molecular; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D015221:Potassium Channels / Q000737:chemistry; D011487:Protein Conformation; D012979:Sodium Radioisotopes
D000475:Alkenes; D004987:Ethers; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D011108:Polymers; D015221:Potassium Channels; D012979:Sodium Radioisotopes