title: Retinal function in diabetic macular edema after focal laser photocoagulation.
abstract: OBJECTIVE
  To assess the effects of focal photocoagulation on retinal function in the macular and perimacular areas in patients with diabetes who have clinically significant macular edema.
  
  
  METHODS
  Eleven patients were assessed after focal laser treatment. Multifocal electroretinogram (ERG) and full-field ERG techniques were used to evaluate the effects of treatment on macular, paramacular, and peripheral retinal function. A modified visual field technique was used to obtain local threshold fields. The posttreatment results were compared with pretreatment results. Changes in local ERG response amplitudes and implicit times were calculated for each patient and presented as difference fields. The changes in local ERG responses were compared with the changes in local field sensitivity.
  
  
  RESULTS
  After treatment, the results of the psychophysical tests suggested little or no change in visual function, but changes in retinal function were observed with the multifocal ERG technique. Local ERG responses showed increases in implicit time and decreases in amplitude, compared with pretreatment values. Timing was affected more than amplitude.
  
  
  CONCLUSIONS
  The results suggest that focal treatment produces changes in retinal function, and these changes are not restricted to the treated macular area.
authors.affiliation: Department of Ophthalmology, New York University School of Medicine, Columbia University, New York, New York 10016, USA. vcg1@is3.nyu.edu
authors.forename: V C
authors.initials: VC
authors.lastname: Greenstein
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: D C
authors.initials: DC
authors.lastname: Hood
authors.forename: K
authors.initials: K
authors.lastname: Holopigian
authors.forename: W
authors.initials: W
authors.lastname: Seiple
authors.forename: R E
authors.initials: RE
authors.lastname: Carr
mesh_terms: D000328:Adult; D000368:Aged; D003930:Diabetic Retinopathy / Q000503:physiopathology / Q000601:surgery*; D004596:Electroretinography / Q000379:methods; D006801:Humans; D017075:Laser Coagulation; D008269:Macular Edema / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D012160:Retina / Q000502:physiology*; D014792:Visual Acuity; D014794:Visual Fields