title: In vitro activity of Rutaceae species against the trypomastigote form of Trypanosoma cruzi.
abstract: The activity of crude plant extracts of nine species of Rutaceae against the trypomastigote form of Trypanosoma cruzi was evaluated at 4 mg/ml. Thirty-two crude extracts were tested and eight of them showed significant activity (>80%). The most active extract was obtained from the stems of Pilocarpus spicatus (97.3%). Fractionation of the active crude extracts provided 25 fractions which were tested against the trypomastigote form of T. cruzi at 2 mg/ml. Of these six showed significant activity (>80%). The most active fractions (100%) were obtained from the leaves of Almeidea coerulea (butanol fraction) and Conchocarpus inopinatus (dichloromethane fraction).
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos-UFSCar, Via Washington Luiz, Km 235, C.P. 676, 13565-905, SP, São Carlos, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Mafezoli
authors.forename: P C
authors.initials: PC
authors.lastname: Vieira
authors.forename: J B
authors.initials: JB
authors.lastname: Fernandes
authors.forename: M F
authors.initials: MF
authors.lastname: da Silva
authors.forename: S
authors.initials: S
authors.lastname: de Albuquerque
mesh_terms: D000818:Animals; D019448:Ethnobotany; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents