A randomized trial of polyurethane and silicone percutaneous endoscopic gastrostomy catheters.
BACKGROUND
No data are available on differences in complication rate and long-term functioning between polyurethane and silicone percutaneous endoscopic gastrostomy (PEG) catheters.


METHODS
We randomized patients who qualified for PEG placement to receive either a polyurethane or silicone PEG catheter. Patients were prospectively monitored for 28 days after placement for the occurrence of complications. Data on long-term PEG survival were obtained retrospectively from the Hospital and general practitioner's medical records.


RESULTS
One hundred and six patients were randomized (polyurethane 50, silicone 56). During the first four weeks of follow-up, major complications occurred twice with both polyurethane and silicone PEGs (relative risk 1.1, 95% confidence interval: 0.11-11). Overall complications occurred four times with polyurethane and 17 times with silicone PEGs (relative risk 3.8, 95% confidence interval: 1.37-10.5). Long-term follow-up was available in 96 patients. Seven polyurethane PEGs and 10 silicone PEGs were removed because of PEG malfunctioning, the remainder functioned well until death or the reinstitution of oral feeding. The median complication-free survival was 916 days for the polyurethane PEG and 354 days for the silicone PEG (Log rank test: P=0.24).


CONCLUSIONS
Polyurethane PEG catheters were associated with less short-term complications than silicone catheters, but major complications and long-term function were comparable.
Van Den Hazel
S J
SJ
Department of Gastroenterology, Rijnstate Hospital, Arnhem, the Netherlands.
Mulder
C J
CJ
Den Hartog
G
G
Thies
J E
JE
Westhof
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002404:Catheterization / Q000009:adverse effects* / Q000295:instrumentation*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy; D005774:Gastrostomy / Q000295:instrumentation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011140:Polyurethanes; D012828:Silicones
D011140:Polyurethanes; D012828:Silicones