Reversal of optic canal stenosis in osteopetrosis after bone marrow transplant.
OBJECTIVE
To describe a patient with infantile osteopetrosis and optic atrophy secondary to optic canal stenosis who demonstrated optic canal enlargement after bone marrow transplant.


METHODS
Case report. A 3-month-old infant with infantile "malignant" osteopetrosis underwent ophthalmic examination, including visual evoked potentials, electroretinogram, and computed tomography (CT). Bone marrow transplant was performed at 8 months of age.


RESULTS
Examination revealed visual loss and optic atrophy, left eye greater than right eye, secondary to optic canal stenosis. Flash visual evoked potentials revealed a normal waveform in both eyes with increased latency in the left eye. Electroretinogram was normal in both eyes. CT after bone marrow transplant showed enlargement of the optic canals. Vision remains stable 43 months after bone marrow transplant.


CONCLUSIONS
Bone marrow transplant in infantile osteopetrosis may be followed by reversal of optic canal stenosis and preservation of vision.
Kerr
N C
NC
Department of Ophthalmology, University of Tennessee, Memphis, Tennessee 38163, USA. nkerr@mail.eye.utmem.edu
Wang
W C
WC
Mohadjer
Y
Y
Haik
B G
BG
Kaste
S C
SC
Horwitz
E M
EM
D016026:Bone Marrow Transplantation; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000517:prevention & control; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007223:Infant; D009896:Optic Atrophy / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000517:prevention & control; D009916:Orbital Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000517:prevention & control; D010022:Osteopetrosis / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000517:prevention & control; D014792:Visual Acuity