title: [Fludarabine treatment of chronic lymphoid leukemia].
abstract: OBJECTIVE
  To try effectiveness of fludarabine monotherapy in verified chronic lymphoid leukemia (CLL) in pretreated patients.
  
  
  METHODS
  The treatment effectiveness according to the international criteria of complete and partial remission was assessed in 37 patients with progressive, splenic, tumor and bone marrow forms of CLL given 5-day courses of fludarabine in a single daily dose 25 mg.
  
  
  RESULTS
  In progressive CLL, the remission was achieved in 45% of the patients (10% complete and 35% partial), in splenic form--62.5% (12.5% complete, 50% partial), in tumor form--50% (100% partial). In bone marrow form no remissions were obtained.
  
  
  CONCLUSIONS
  Fludarabine is effective in therapy of pretreated CLL patients. The treatment should be adjusted to CLL form.
authors.forename: N G
authors.initials: NG
authors.lastname: Gabeeva
authors.forename: A V
authors.initials: AV
authors.lastname: Pivnik
authors.forename: T N
authors.initials: TN
authors.lastname: Moiseeva
authors.forename: E E
authors.initials: EE
authors.lastname: Zybunova
authors.forename: R S
authors.initials: RS
authors.lastname: Samoĭlova
authors.forename: A M
authors.initials: AM
authors.lastname: Kremenetskaia
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Varlamova
authors.forename: I B
authors.initials: IB
authors.lastname: Kaplanskaia
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001853:Bone Marrow / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D012189:Retrospective Studies; D014740:Vidarabine / Q000008:administration & dosage* / Q000031:analogs & derivatives*
chemical_list: D000970:Antineoplastic Agents; D014740:Vidarabine; C024352:fludarabine