A role for adenosine in modulating cardio-respiratory responses: a mini-review.
Evidence is provided that purine nucleotides play a major role in modulating cardio-respiratory control through actions at specific sites in the central nervous system (CNS). The accumulation of adenosine in the extracellular space of the nucleus tractus solitarius (NTS) on hypothalamic defence area stimulation is described, and is shown to result from the extracellular breakdown of neurally released adenosine triphosphate (ATP). The actions of adenosine in modulating synaptic actions in the NTS are discussed in relation to the potential presynaptic action of adenosine in modulating transmitter release. Actions of adenosine and ATP at other sites in the medulla concerned with cardio-respiratory control are discussed. The inter-relationships between ATP and adenosine are mentioned.
Spyer
K M
KM
Royal Free Campus, Royal Free and University College Medical School, London, UK. k.spyer@ucl.ac.uk
Thomas
T
T
D000241:Adenosine / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001341:Autonomic Nervous System / Q000166:cytology / Q000378:metabolism*; D002320:Cardiovascular Physiological Phenomena; D005239:Fear / Q000502:physiology / Q000523:psychology; D006801:Humans; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D009434:Neural Pathways / Q000166:cytology / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D012018:Reflex / Q000502:physiology*; D012143:Respiratory Physiological Phenomena; D017552:Solitary Nucleus / Q000166:cytology / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism / Q000648:ultrastructure
D018377:Neurotransmitter Agents; D000255:Adenosine Triphosphate; D000241:Adenosine