title: O-Glycosyl trichloroacetimidates bearing Fmoc as temporary hydroxy protecting group: a new access to solid-phase oligosaccharide synthesis.
abstract: Different O-glycosyl trichloroacetimidates bearing base sensitive Fmoc protected hydroxy groups were efficiently prepared with CCl(3)CN using a catalytic amount of sodium hydride. The resulting glycosyl donors were engaged in glycosylation reactions both in solution and on solid support with a new ester-type linker with good results. In both approaches, Fmoc groups were afterward quantitatively cleaved using mild basic conditions.
authors.affiliation: Fakultät für Chemie, Universität Konstanz, Fach M 725, D-78457 Konstanz, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Roussel
authors.forename: L
authors.initials: L
authors.lastname: Knerr
authors.forename: M
authors.initials: M
authors.lastname: Grathwohl
authors.forename: R R
authors.initials: RR
authors.lastname: Schmidt
mesh_terms: D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis*
chemical_list: D009844:Oligosaccharides