Current perception thresholds of epileptic patients treated with valproate.
We investigated the current perception threshold (CPT) of epileptic patients treated with valproate. The CPTs at frequencies of 5 Hz, 250 Hz and 2000 Hz in the control group of patients were 198.9 +/- 15.8, 62.0 +/- 18.9 and 35.3 +/- 15.8, respectively. The CPTs at 5 Hz, 250 Hz and 2000 Hz in the epileptic group of patients were 350.6 +/- 61.3, 338.6 +/- 64.3 and 193.2 +/- 21.1, respectively. The CPTs at 5 Hz, 250 Hz and 2000 Hz in the epileptic group were significantly higher than those of the control group. We measured the CPTs for 6 months after the administration of valproate in three patients with traumatic epilepsy. Their CPTs were higher than that of the epileptic group. The CPTs at 5 Hz, 250 Hz and 2000 Hz reached a maximum 4 weeks after the administration of valproate for two of these patients and in 6 weeks for the other patient. When the administration of valproate to a patient was stopped, CPTs decreased.
Kudoh
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Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, 036-8216, Japan.
Matsuki
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D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000097:blood; D016022:Case-Control Studies; D004827:Epilepsy / Q000097:blood / Q000503:physiopathology*; D004834:Epilepsy, Post-Traumatic / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D009475:Neurons, Afferent / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D017933:Peripheral Nervous System / Q000187:drug effects* / Q000503:physiopathology; D004561:Transcutaneous Electric Nerve Stimulation; D014635:Valproic Acid / Q000009:adverse effects* / Q000097:blood
D000927:Anticonvulsants; D014635:Valproic Acid