title: The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci.
abstract: Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2 diabetes-related quantitative traits in 580 Finnish families ascertained for an affected sibling pair and analyzed by the variance components-based quantitative-trait locus (QTL) linkage approach. We analyzed diabetic and nondiabetic subjects separately, because of the possible impact of disease on the traits of interest. In diabetic individuals, our strongest results were observed on chromosomes 3 (fasting C-peptide/glucose: maximum LOD score [MLS] = 3.13 at 53.0 cM) and 13 (body-mass index: MLS = 3.28 at 5.0 cM). In nondiabetic individuals, the strongest results were observed on chromosomes 10 (acute insulin response: MLS = 3.11 at 21.0 cM), 13 (2-h insulin: MLS = 2.86 at 65.5 cM), and 17 (fasting insulin/glucose ratio: MLS = 3.20 at 9.0 cM). In several cases, there was evidence for overlapping signals between diabetic and nondiabetic individuals; therefore we performed joint analyses. In these joint analyses, we observed strong signals for chromosomes 3 (body-mass index: MLS = 3.43 at 59.5 cM), 17 (empirical insulin-resistance index: MLS = 3.61 at 0.0 cM), and 19 (empirical insulin-resistance index: MLS = 2.80 at 74.5 cM). Integrating genome-scan results from the companion article by Ghosh et al., we identify several regions that may harbor susceptibility genes for type 2 diabetes in the Finnish population.
authors.affiliation: Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: C D
authors.initials: CD
authors.lastname: Langefeld
authors.forename: T T
authors.initials: TT
authors.lastname: Valle
authors.forename: E R
authors.initials: ER
authors.lastname: Hauser
authors.forename: V L
authors.initials: VL
authors.lastname: Magnuson
authors.forename: K L
authors.initials: KL
authors.lastname: Mohlke
authors.forename: K
authors.initials: K
authors.lastname: Silander
authors.forename: D S
authors.initials: DS
authors.lastname: Ally
authors.forename: P
authors.initials: P
authors.lastname: Chines
authors.forename: J
authors.initials: J
authors.lastname: Blaschak-Harvan
authors.forename: J A
authors.initials: JA
authors.lastname: Douglas
authors.forename: W L
authors.initials: WL
authors.lastname: Duren
authors.forename: M P
authors.initials: MP
authors.lastname: Epstein
authors.forename: T E
authors.initials: TE
authors.lastname: Fingerlin
authors.forename: H S
authors.initials: HS
authors.lastname: Kaleta
authors.forename: E M
authors.initials: EM
authors.lastname: Lange
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: R C
authors.initials: RC
authors.lastname: McEachin
authors.forename: H M
authors.initials: HM
authors.lastname: Stringham
authors.forename: E
authors.initials: E
authors.lastname: Trager
authors.forename: P P
authors.initials: PP
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: Balow
authors.forename: G
authors.initials: G
authors.lastname: Birznieks
authors.forename: J
authors.initials: J
authors.lastname: Chang
authors.forename: W
authors.initials: W
authors.lastname: Eldridge
mesh_terms: D000367:Age Factors; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002877:Chromosomes, Human / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D005215:Fasting; D005260:Female; D005387:Finland; D008040:Genetic Linkage / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009679:Nuclear Family; D019655:Quantitative Trait, Heritable; D012737:Sex Factors; D014481:United States
chemical_list: D001786:Blood Glucose; D007328:Insulin