title: [Changes in myopic refractive errors after 9 months of extensive wear of hydrogel lenses with high oxygen permeability and compared with those with low permeability].
abstract: BACKGROUND
  A small but significant increase in myopia after extended wear of low oxygen permeability (Dk) hydrogel lenses has been previously reported; however, the specific impact of hypoxia on refractive status and corneal curvature with extended wear are not well documented. THE PURPOSE of this study was to compare the refractive changes induced over a period of 9 months' extended wear with high-Dk fluorosiloxane hydrogel lenses and low-Dk hydrogel lenses.
  
  
  METHODS
  Adapted daily wear contact lens wearers were randomly assigned to one of two groups. The low-Dk group wore etafilcon A (Dk = 28) for up to 7 days and 6 nights and the high-Dk group wore lotrafilcon A (Dk = 140) for up to 30 days and nights. Refractive error and corneal curvature were measured at 3-month intervals over 9 month of extended wear.
  
  
  RESULTS
  The etafilcon A group demonstrated an average increase in myopia of 0.30 D over the 9 months period; however, no change in spherical myopic correction was measured in the lotrafilcon A group. The cylindrical component did not change in either group. A stratified analysis revealed a greater increase in myopia for low myopes than moderate myopes in the etafilcon A group but no difference in the lotrafilcon A group. Keratometric analysis revealed no change in the etafilcon A group and a small degree of central corneal flattering in both major meridians of 0.35 D in the lotrafilcon A group.
  
  
  CONCLUSIONS
  Nine months of extended wear of low-Dk lenses is associated with a small degree of myopic progression in adult myopes that appears to be reversible. Wearing fluorosiloxane-hydrogel lenses of high-Dk had no impact on refractive error and may be associated with a small degree of central corneal flattering.
authors.affiliation: Clinica de Oftalmologie, Spitalul Militar Central, Bucureşti.
authors.forename: M
authors.initials: M
authors.lastname: Filip
authors.forename: I
authors.initials: I
authors.lastname: Stefăniu
authors.forename: C
authors.initials: C
authors.lastname: Stefan
mesh_terms: D000328:Adult; D003262:Contact Lenses, Extended-Wear / Q000706:statistics & numerical data; D003263:Contact Lenses, Hydrophilic / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D009216:Myopia / Q000503:physiopathology / Q000628:therapy*; D010100:Oxygen / Q000378:metabolism; D010539:Permeability; D012029:Refraction, Ocular; D012833:Siloxanes; D013997:Time Factors
chemical_list: D012833:Siloxanes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010100:Oxygen