title: Symptomatic fibroleiomyomata: MR imaging of the uterus before and after uterine arterial embolization.
abstract: OBJECTIVE
  To determine the magnetic resonance (MR) imaging features of uterine fibroleiomyomata after uterine arterial embolization (UAE) and identify pretreatment MR imaging features that may be predictive of successful UAE.
  
  
  METHODS
  T1- and T2-weighted and dynamic gadolinium-enhanced T1-weighted images were obtained before and 3 months after UAE in 31 patients. Up to five fibroleiomyomata (total of 125) were evaluated for volume, location, signal intensity characteristics, and vascularity. Region-of-interest curves were used to assess the vascular enhancement pattern of each fibroleiomyoma and adjacent myometrium. Each patient completed a questionnaire on symptoms 3 months after UAE.
  
  
  RESULTS
  UAE resulted in significant reductions in mean uterine volume (from 588.6 to 393.1 cm(3)) and mean fibroleiomyoma volume (from 69.4 to 41.4 cm(3)) (P <.005). After UAE, lesions showed signal intensity changes consistent with hemorrhagic infarction. The vascularity of fibroleiomyomata was decreased (P <.001), with no significant change in myometrial vascularity. Submucosal location was a strong positive predictor of fibroleiomyoma volume reduction (P < 001). When a reduction in vascularity was the measure of success, hypervascularity was a strong indicator of success (P <. 005).
  
  
  CONCLUSIONS
  MR imaging is useful for quantitative assessment of signal intensity and morphologic changes before and after UAE. Pretreatment MR imaging findings may help predict the success of the procedure.
authors.affiliation: Department of Radiology, Georgetown University Medical Center, 3800 Reservoir Road NW, Washington DC, 20007, USA. jhar@gunet.georgetown.edu
authors.forename: R C
authors.initials: RC
authors.lastname: Jha
authors.forename: S M
authors.initials: SM
authors.lastname: Ascher
authors.forename: I
authors.initials: I
authors.lastname: Imaoka
authors.forename: J B
authors.initials: JB
authors.lastname: Spies
mesh_terms: D000328:Adult; D003287:Contrast Media; D004621:Embolization, Therapeutic; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007889:Leiomyoma / Q000098:blood supply / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011237:Predictive Value of Tests; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000628:therapy
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA