title: An evaluation of the hemostatic effect of externally applied notoginseng and notoginseng total saponins.
abstract: No effective hemostatic agents are available for external use. This project was conducted to evaluate the hemostatic effects of notoginseng using a hemorrhagic rat model. Rats (n = 40) were divided into four groups, and their tails were transected 5 mm from the tip. Group 1 received no treatment (control), while the other groups received external powder applied to the wound. Group 2 received placebo (flour), group 3 received ground notoginseng, and group 4 received a saponin extract of notoginseng. The total bleeding time was determined and compared between groups. The notoginseng group had lower bleeding times (9.60 +/- 1.50 min) than the control group (19.23 +/- 4.09 min, p < 0.001) or the placebo group (15.18 +/- 2.24 min, p < 0.001). Likewise, the saponin extract group had significantly lower bleeding times (11.70 +/- 2.53 min) than the control and placebo groups (p < 0.001 for both comparisons). No differences were found between the notoginseng and the saponin extract groups (p = 0.35). Notoginseng and a saponin extract from notoginseng provide hemostatic effects when applied externally.
authors.affiliation: Hartford Hospital, Department of Pharmacy, Connecticut, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: White
authors.forename: C
authors.initials: C
authors.lastname: Fan
authors.forename: M
authors.initials: M
authors.lastname: Chow
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001760:Bleeding Time; D004341:Drug Evaluation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology*; D023421:Models, Animal; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D006490:Hemostatics; D010936:Plant Extracts; D012503:Saponins