title: The development of a phantom to determine foetal organ doses from 131I in the foetal thyroid.
abstract: Iodine can accumulate in the foetal thyroid from the twelfth week of gestation onwards. If the iodine taken up by the foetal thyroid is in the form of 131I then the thyroid and its proximal tissues and organs will be irradiated. Several mathematical models exist in the literature on foetal/maternal iodine kinetics. However, very few studies have been performed where the foetal thyroid had been physically modelled thus allowing the determination of foetal organ dosimetry from 131I in the foetal thyroid. Here, the development of such a physical model or phantom is described and dosimetry results obtained from the phantom are discussed. The phantom is of Perspex construction, the dimensions of which are sufficient to incorporate models of the foetus at 16, 24 and 36 weeks' gestational age. The dosimetry of two organs is presented, that of the brain and the thymus. The results show that the measured absorbed dose is comparable with that calculated using modified MIRD dosimetry and traditional methods. The results also show that the dose to the thymus is greater than that of the brain by a factor of almost 30 for 16 weeks' gestational age.
authors.affiliation: MPBE Department, St James's Hospital, Dublin, Ireland.
authors.forename: N
authors.initials: N
authors.lastname: O'Hare
authors.forename: D
authors.initials: D
authors.lastname: Murphy
authors.forename: J F
authors.initials: JF
authors.lastname: Malone
mesh_terms: D001921:Brain / Q000196:embryology; D002138:Calibration; D005260:Female; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange; D008954:Models, Biological; D019047:Phantoms, Imaging; D019904:Polymethyl Methacrylate; D011247:Pregnancy; D011829:Radiation Dosage; D013961:Thyroid Gland / Q000196:embryology*
chemical_list: D007457:Iodine Radioisotopes; D019904:Polymethyl Methacrylate