Expression of intercellular adhesion molecule-1 in C6 glioma cells is up-regulated by thyroid hormone.
ICAM-1 is a cell surface adhesion glycoprotein playing an essential role in inflammatory responses. We have investigated the effects of the thyroid hormone T3 on the expression of the ICAM-1 gene in C6 glioma cells. In these cells, T3 stimulated the ICAM-1 protein expression significantly after 24 h of treatment. The induction of ICAM-1 by cytokines such as interleukin 1beta or tumour necrosis factor TNF as well as by lipopolysaccharide or T3 can be suppressed by the two anti-inflammatory compounds dexamethasone and parthenolide. The C6 glioma cell line could then be a useful model for studying the effect of T3 hormone on the expression of specific genes in glial cells, especially genes involved in lymphocyte-glial cell interactions.
Dietrich
J B
JB
INSERM U 338, Strasbourg, France.
Zaepfel
M
M
Kuchler-Bopp
S
S
D000199:Actins / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D003907:Dexamethasone / Q000494:pharmacology; D004660:Encephalitis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000502:physiology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D023421:Models, Animal; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology; D014284:Triiodothyronine / Q000378:metabolism / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D014746:Vimentin / Q000378:metabolism
D000199:Actins; D005904:Glial Fibrillary Acidic Protein; D007375:Interleukin-1; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha; D014746:Vimentin; D014284:Triiodothyronine; D018799:Intercellular Adhesion Molecule-1; C002669:parthenolide; D003907:Dexamethasone