[Drug stimulation of the peripheral nerve regeneration].
A comparative study of the effects of xymedone, riboxin, and piracetam upon the regeneration of myelinated axons and the number of surviving sensory neurons in spinal ganglia L4-L5 was studied on the model of sciatic nerve transection in rats. The three drugs decrease the number of neurons entering the posttraumatic apoptosis. Riboxin and xymedone stimulate the regeneration of myelinated axons, the latter drug being more effective and producing a 21.3 and 14.7% increase in the number of regenerated myelinated axons and a 29.3 and 37.7% increase in the relative number of sensory neurons (the transected/contralateral side ratio) in spinal ganglia L4-L5 relative to control by the 60th and 90th day upon transection, respectively.
Chelyshev
Iu A
IuA
Histology Department, State Medical University, Kazan, Tatarstan, Russia.
Khafiz'ianova
R Kh
RKh
Raginov
I S
IS
Vafin
A Iu
AIu
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D005727:Ganglia, Spinal / Q000166:cytology; D007290:Inosine Diphosphate / Q000494:pharmacology*; D009186:Myelin Sheath / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D009416:Nerve Regeneration / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology
D018697:Nootropic Agents; D011743:Pyrimidines; C069705:xymedon; D007290:Inosine Diphosphate; D010889:Piracetam