title: A case report of advanced male breast cancer with an objective response to tamoxifen treatment.
abstract: A 70-year-old man presented with a firm tumor in his right breast first noticed eight years ago. The tumor had enlarged gradually and had produced an ulcer with bleeding. On physical examination, a huge tumor entirely occupied the right breast and extensively had infiltrated the chest wall. Chest X-ray and CT showed massive pleural effusion and multiple small nodular lesions in the lung. Invasive ductal carcinoma of the breast was diagnosed by incisional biopsy,confirming advanced breast cancer with lung metastases and bilateral pleural effusion(T4cN2M1, Stage IV). Because ER and PgR levels were 110 fmol/mg and 190 fmol/mg, respectively, and because his general condition was poor, we selected medical treatment with tamoxifen(TAM). Thirty-two weeks later, the tumor had showed pronounced reduction with scarring. The patient underwent local excision of the scar tissue. The quality of life of the patient was favorably improved and no severe adverse events were observed. The tumor in the chest wall recurred two months after the end of TAM treatment, possibly because the patient did not accept continuous TAM therapy. The patient died from complications of brain metastasis 32 months after the start of TAM treatment. We report a rare case of advanced male breast cancer and on the effectiveness of continuous TAM treatment.
authors.affiliation: Second Department of Surgery, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kanoh
authors.forename: Y
authors.initials: Y
authors.lastname: Iino
authors.forename: J
authors.initials: J
authors.lastname: Horiguchi
authors.forename: H
authors.initials: H
authors.lastname: Takei
authors.forename: M
authors.initials: M
authors.lastname: Maemura
authors.forename: T
authors.initials: T
authors.lastname: Yokoe
authors.forename: Y
authors.initials: Y
authors.lastname: Morishita
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001706:Biopsy; D001932:Brain Neoplasms / Q000556:secondary*; D018567:Breast Neoplasms, Male / Q000188:drug therapy* / Q000473:pathology* / Q000523:psychology; D018270:Carcinoma, Ductal, Breast / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D009367:Neoplasm Staging; D011788:Quality of Life; D013629:Tamoxifen / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen