title: Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen.
abstract: A new allele of the human neutrophil antigen (HNA) system (tentatively called NA2M) was discovered and its nucleotide sequence was determined. NA2M differs in a single nucleotide (193G-->A) from FCGR3B*2(NA2), resulting in an amino acid change (54Glu-->Lys). The frequency of the NA2M gene in the Japanese population was estimated to be 0.008. Granulocytes of individuals possessing NA2M reacted with HNA-1b(NA2)-specific monoclonal antibody (TAG2) in the GIFT assay.
authors.affiliation: Transfusion Information Department, Japanese Red Cross Central Blood Center, Tokyo. watanabe@cbc.jrc.or.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: E
authors.initials: E
authors.lastname: Shimada
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
authors.forename: H
authors.initials: H
authors.lastname: Niihara
authors.forename: K
authors.initials: K
authors.lastname: Shimano
authors.forename: S
authors.initials: S
authors.lastname: Mitsunaga
authors.forename: K
authors.initials: K
authors.lastname: Tadokoro
authors.forename: T
authors.initials: T
authors.lastname: Juji
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D015703:Antigens, CD; D001483:Base Sequence; D058851:GPI-Linked Proteins; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007519:Isoantigens / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D017385:Sequence Homology
chemical_list: D015703:Antigens, CD; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D007519:Isoantigens; D017452:Receptors, IgG; C072753:neutrophil-specific antigen NA2