title: Absence of chicken myelin basic protein residues in commercial formulations of MMR vaccine.
abstract: Several preparations of MMR vaccines and their progenitor monovalent vaccine bulks produced by two different manufacturers were examined serologically for the presence of chicken myelin basic protein (MBP) residues. The products were challenged against several commercial preparations of anti-hMBP antisera that reacted positively with the control MBP preparations of human and chicken origins. There was no evidence of the presence of MBP components in MMR vaccines or their progenitor vaccine bulks as shown by the reactivity profiles of the antibody preparations against control and test antigens.
authors.affiliation: Division of Virology, National Institute for Biological Standards and Control, South Mimms, Blanche Lane, Potters Bar, EN6 3QG, Hertfordshire, UK. mafzal@nibsc.ac.uk
authors.forename: M A
authors.initials: MA
authors.lastname: Afzal
authors.forename: P A
authors.initials: PA
authors.lastname: Pipkin
authors.forename: P D
authors.initials: PD
authors.lastname: Minor
mesh_terms: D000418:Albumins / Q000276:immunology; D000818:Animals; D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D001321:Autistic Disorder / Q000209:etiology; D015551:Autoimmunity; D002626:Chemistry, Pharmaceutical; D002645:Chickens; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects / Q000276:immunology* / Q000302:isolation & purification*; D004676:Myelin Basic Protein / Q000009:adverse effects / Q000276:immunology* / Q000302:isolation & purification*; D012449:Safety
chemical_list: D000418:Albumins; D022542:Measles-Mumps-Rubella Vaccine; D004676:Myelin Basic Protein