Treatment of latent tuberculosis infection in patients aged > or =35 years.
Treating patients aged > or =35 years for tuberculosis infection has been controversial because of the hepatotoxic effects of isoniazid. A 2-year retrospective cohort study of outpatient medical records determined the completion rate in this age group and identified risk factors associated with isoniazid-associated hepatotoxicity. Isoniazid preventative therapy was well tolerated. However, toxicity occurred in women receiving concomitant medications and men who used alcohol.
Gilroy
S A
SA
Department of Medicine, Division of Infectious Diseases, SUNY Upstate Medical University, Syracuse, NY 13210, USA. gilroys@upstate.edu
Rogers
M A
MA
Blair
D C
DC
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D018771:Arthralgia / Q000139:chemically induced; D015331:Cohort Studies; D005076:Exanthema / Q000139:chemically induced; D005221:Fatigue / Q000139:chemically induced; D005500:Follow-Up Studies; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010349:Patient Compliance; D012189:Retrospective Studies; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000208:ethnology / Q000517:prevention & control*; D014481:United States / Q000453:epidemiology
D000410:Alanine Transaminase; D007538:Isoniazid