Synthesis, utility, and X-ray crystal structure of novel complexes of baccatin III with imidazole and 2-propanol.
Baccatin III forms crystalline complexes 4 and 5 with imidazole and 2-propanol, respectively. These compounds are useful in the purification of baccatin III from mixtures of taxanes derived from plant-cell fermentation.
Gibson
F S
FS
Bristol-Myers Squibb Company, Process Exploration Labs, Technical Operations Development, P.O. Box 4755, Syracuse, New York 13221-4755, USA.
Wei
J
J
Vemishetti
P
P
Gao
Q
Q
Dillon
J L
JL
D019840:2-Propanol / Q000737:chemistry*; D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal; D007093:Imidazoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation; D043823:Taxoids
D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D007093:Imidazoles; D043823:Taxoids; C073950:baccatin III; D019840:2-Propanol