Mutagenic activity of cyclohexene and products of its chlorination.
Cyclohexene exhibits no mutagenic effect in the Ames test. Products of its transformation (chlorination) produced a mutagenic effect in the Ames test on TA 100 strain without metabolic activation and in the micronucleus test on epithelial cells from mouse urinary bladder and colon. These findings are consistent with epidemiological data on higher incidence of urinary bladder and rectal cancers in subjects consuming chlorinated drinking water from surface water reservoirs.
Sycheva
L P
LP
Laboratory of Mutagenesis and Laboratory of Complex Ecological and Hygienic Standardization, A. N. Sysin Institute of Human Ecology and Environmental Hygiene, Russian Academy of Medical Sciences, Moscow. sysen@elnet.msk.ru
Zholdakova
Z I
ZI
Polyakova
E E
EE
Lukmanova
N E
NE
Akhal'tseva
L V
LV
Zhurkov
V S
VS
D000818:Animals; D001711:Biotransformation; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002478:Cells, Cultured; D002713:Chlorine / Q000378:metabolism*; D003106:Colon / Q000166:cytology / Q000187:drug effects; D003510:Cyclohexanes / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D053138:Cyclohexenes; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009154:Mutation; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000166:cytology / Q000187:drug effects
D003510:Cyclohexanes; D053138:Cyclohexenes; C052568:cyclohexene; D002713:Chlorine