Synthesis of iron-crosslinked hydroxamated alginic acid and its in vitro evaluation as a potential matrix material for oral sustained-release beads.
Hydroxamated alginic acid (HAA) was prepared. The generated semisynthetic polymer was employed in the formation of drug-loaded, iron(III)-crosslinked polymeric beads. Infrared spectroscopy was employed to prove the crosslinking. The degree of hydroxamate substitution was determined by acid-base back titration, and it was found to be ca. 20%. The produced beads were evaluated in vitro as orally administered sustained release drug delivery system. Theophylline, paracetamol, and chlorpheniramine maleate were used as model drugs. The generated beads proved to be successful in prolonging drug release, particularly in the case of theophylline. Iron leaching from the generated beads was minimal (< 0.5% of the entire complexed iron), and took place during passage through the simulated gastric fluid.
Taha
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Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan.
Aiedeh
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D000082:Acetaminophen / Q000008:administration & dosage; D000464:Alginates / Q000138:chemical synthesis* / Q000737:chemistry; D002744:Chlorpheniramine / Q000008:administration & dosage; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013806:Theophylline / Q000008:administration & dosage
D000464:Alginates; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006877:Hydroxamic Acids; D000082:Acetaminophen; D002744:Chlorpheniramine; D013806:Theophylline