[The mineral dietary composition affects glucose metabolism and modulates insulin effect in intact rats].
The experiments on intact rats showed that an excess sodium chloride consumption and the use of giposol (NaCl substitute) produce a hypoglycemic effect. Giposol increases, whereas NaCl decreases, the glucose tolerance. Giposol activates hexokinase and glucose-6-phosphate dehydrogenase (the key enzymes of the glucose metabolism in tissues) and reduces the effect of insulin. Both giposol and NaCl increase the level of glucose absorption in small intestine. The gastric motility is activated by NaCl and not affected by giposol.
Ratyni
O A
OA
Department of Pharmacology and General, Chemistry, Ivanovo State Medical Academy, Russia.
Shtrygol'
S Iu
SIu
Slobodin
V B
VB
Sadin
A V
AV
Nazarenko
M E
ME
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004338:Drug Combinations; D004347:Drug Interactions; D004789:Enzyme Activation; D005769:Gastrointestinal Motility / Q000187:drug effects; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D007421:Intestine, Small / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D011189:Potassium Chloride / Q000494:pharmacology*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*
D001786:Blood Glucose; D004338:Drug Combinations; D007004:Hypoglycemic Agents; C094275:Hyposol; D007328:Insulin; D017673:Sodium Chloride, Dietary; D012965:Sodium Chloride; D011189:Potassium Chloride; D008278:Magnesium Sulfate; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D005947:Glucose