title: Development of a completely encapsulated intraocular pressure sensor.
abstract: A completely encapsulated intraocular pressure (IOP) sensor equipped with telemetric signal and energy transfer is introduced integrated into a silicone disc for implantation into the eye. After implantation into enucleated pig eyes and into rabbit eyes in vivo, the IOP was recorded and compared to established techniques of IOP measurement. Pressure chamber tests showed that the sensor functioned correctly after biocompatible encapsulation in polydimethylsiloxane. In vivo and in vitro tests in rabbit and pig eyes demonstrated that the implanted system worked with the same precision as established techniques for IOP determination. The correlation between the measurements with the implanted device and pneumotonometry in several experiments was between 0.9 and 0.99. This device serves as a functioning model for the realization of a telemetric IOP sensor for integration into an artificial intraocular lens. Such a device will open new perspectives, not only in the management of glaucoma, but also in basic research for mechanisms of glaucoma.
authors.affiliation: Department of Ophthalmology, University of Cologne, Germany. aia08@uni-koeln.de
authors.forename: P
authors.initials: P
authors.lastname: Walter
authors.forename: U
authors.initials: U
authors.lastname: Schnakenberg
authors.forename: G
authors.initials: G
authors.lastname: vom Bögel
authors.forename: P
authors.initials: P
authors.lastname: Ruokonen
authors.forename: C
authors.initials: C
authors.lastname: Krüger
authors.forename: S
authors.initials: S
authors.lastname: Dinslage
authors.forename: H C
authors.initials: HC
authors.lastname: Lüdtke Handjery
authors.forename: H
authors.initials: H
authors.lastname: Richter
authors.forename: W
authors.initials: W
authors.lastname: Mokwa
authors.forename: M
authors.initials: M
authors.lastname: Diestelhorst
authors.forename: G K
authors.initials: GK
authors.lastname: Krieglstein
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D020007:Implants, Experimental; D007429:Intraocular Pressure; D019736:Prostheses and Implants; D011817:Rabbits; D013552:Swine; D013686:Telemetry / Q000295:instrumentation / Q000379:methods; D014065:Tonometry, Ocular / Q000295:instrumentation* / Q000379:methods; D014822:Vitreous Body / Q000601:surgery
chemical_list: D001672:Biocompatible Materials