title: Translocation (8;16) in a patient with acute myelomonocytic leukemia, occurring after treatment with fludarabine for a low-grade non-Hodgkin's lymphoma.
abstract: We describe a 65-year old woman who developed a t(8;16)(p11;p13) positive acute myeloid leukemia (AML)-M4 without a prior myelodysplasia thirty-six months after a low-grade non-Hodgkin's lymphoma treated with alkylating agents (chlorambucil and cyclophosphamide) and fludarabine, a purine analog with a significant activity in lymphoproliferative disorders. The t(8;16)(p11;p13) is present in 0.4% of AML of M4-M5 cytotype. In the present case it was identified by conventional cytogenetics; involvement of the MOZ and CBP genes was demonstrated by fluorescence in situ hybridization, but not by reverse transcription polymerase chain reaction. The patient died of sepsis after the first course of induction chemotherapy. This is the first t(8;16) AML-M4 arising after fludarabine treatment of which the leukemogenic role in our case is very difficult to ascertain. Most t(8;16) t-AML cases had received anthracyclines with or without cyclophosphamide; none was ever administered chlorambucil. Our patient was never given anthracyclines and the cumulative doses of chlorambucil and cyclophosphamide employed were low.
authors.affiliation: Divisione di Ematologia, Policlinico San Matteo IRCCS, piazzale Golgi 1, 27100 Pavia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Bernasconi
authors.forename: E
authors.initials: E
authors.lastname: Orlandi
authors.forename: P
authors.initials: P
authors.lastname: Cavigliano
authors.forename: S
authors.initials: S
authors.lastname: Calatroni
authors.forename: M
authors.initials: M
authors.lastname: Boni
authors.forename: C
authors.initials: C
authors.lastname: Astori
authors.forename: G
authors.initials: G
authors.lastname: Pagnucco
authors.forename: S
authors.initials: S
authors.lastname: Giglio
authors.forename: M
authors.initials: M
authors.lastname: Caresana
authors.forename: M
authors.initials: M
authors.lastname: Lazzarino
authors.forename: C
authors.initials: C
authors.lastname: Bernasconi
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002885:Chromosomes, Human, Pair 16; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology*; D016609:Neoplasms, Second Primary; D014178:Translocation, Genetic; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014740:Vidarabine; C024352:fludarabine