Drug-induced liver disease.
The incidence of drug-induced liver disease appears to be increasing, reflecting the increasing number of new agents that have been introduced into clinical use over the past several decades. Among the topics covered, the author discusses incidence, diagnosis, risk factors, clinical presentations, hepatitis, and vascular injury. The author also reviews the hepatic injury seen with commonly prescribed drugs, emphasizing newer developments in the field and recent publications and reports.
Lewis
J H
JH
Department of Medicine, Georgetown University School of Medicine, Washington, DC, USA.
D000082:Acetaminophen / Q000009:adverse effects; D000410:Alanine Transaminase / Q000097:blood; D000890:Anti-Infective Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001219:Aspartate Aminotransferases / Q000097:blood; D002317:Cardiovascular Agents / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D002779:Cholestasis / Q000139:chemically induced; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects; D015994:Incidence; D008099:Liver / Q000098:blood supply / Q000187:drug effects; D008107:Liver Diseases / Q000175:diagnosis / Q000503:physiopathology; D011379:Prognosis; D012307:Risk Factors; D014652:Vascular Diseases / Q000139:chemically induced
D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002317:Cardiovascular Agents; D007004:Hypoglycemic Agents; D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase