title: Recent cocaine use is not associated with fetal acidemia or other manifestations of intrapartum fetal distress.
abstract: The objective of this paper is to evaluate the impact of recent cocaine use on umbilical cord blood gas values in cocaine-dependent pregnant women who received formal prenatal care. Ninety-two cocaine-dependent pregnant women receiving comprehensive prenatal care were divided into two groups, with patients in Group A (n = 35) testing positive for cocaine metabolites at the time of delivery and Group B (n = 57) testing negative. One hundred and three patients with no history of drug or alcohol dependence served as the control group (Group C). Umbilical cord blood gases were obtained at all deliveries. Additional variables included 1 and 5-min Apgar scores, meconium staining of the amniotic fluid, route of delivery, premature rupture of the membranes, and length of nursery stay. There were no statistically significant differences between groups in either umbilical artery pH, pO2, pCO2, bicarbonate, or base excess. Similarly, there was no difference in meconium staining of the amniotic fluid, depressed Apgar scores, cesarean delivery, or neonatal length of stay. Our data do not support an association between recent cocaine use and fetal hypoxemia or acidemia, depressed 5-min Apgar scores, meconium staining of the amniotic fluid, or cesarean delivery in cocaine-dependent pregnant women enrolled in prenatal care.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Houston Health Science Center, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Andres
authors.forename: M C
authors.initials: MC
authors.lastname: Day
authors.forename: K
authors.initials: K
authors.lastname: Larrabee
mesh_terms: D000138:Acidosis / Q000209:etiology; D000328:Adult; D001784:Blood Gas Analysis; D019970:Cocaine-Related Disorders; D005260:Female; D005316:Fetal Distress / Q000209:etiology*; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012189:Retrospective Studies