[Stereospecific anomalies in the structure of DNA from chromosomes V, XII, XIII, XIV, XV and XVI of saccharomycetes yeasts].
Using an original computer program we analysed complete nucleotide sequences of chromosomes V, XII, XIII, XIV, XV, and XVI in yeast. The full catalogue of 5 highest stereospecific anomalies and of stereospecific anomalies for 5 genes with highest CAI in each chromosome has been presented. Trains of different stereospecific anomalies, possibly showing areas of cooperative binding of different regulatory and structural proteins to DNA, are documented (see: Soidla, Lukina, 1998, 1999). Together with confirming the earlier noticed association between stereospecific anomalies and genes with high expression level (coding mostly proteins of translation machinery of the cell and glycolytic enzymes), here we can also notice an obviously high incidence of transcription apparatus genes being located at (or near) largest stereospecific anomalies. Intracellular transport genes and genes whose products function in the cell nucleus may also be often associated with largest stereospecific anomalies.
Lukina
N I
NI
St. Petersburg Technical University.
Soĭdla
T R
TR
D002869:Chromosome Aberrations; D015825:Chromosomes, Fungal; D004271:DNA, Fungal / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D004718:Saccharomycetales / Q000235:genetics*
D004271:DNA, Fungal