title: CD5+ immunophenotype in the bone marrow but not in the peripheral blood in a patient with hairy cell leukemia.
abstract: We report the case of a patient with rare CD5+ hairy cell leukemia, which was unusual, as there was also a discrepancy between the bone marrow and peripheral blood immunophenotypes. We propose that some degree of maturation within the malignant clone and the predominance of more mature CD5- hairy cells in the peripheral blood can explain this observation. The patient was treated with a conventional course of cladribine (2'-chlorodeoxyadenosine) and achieved complete remission. We conclude that the unusual CD5+ immunophenotype of this patient did not affect prognosis or change the response to standard therapy.
authors.affiliation: Section of Hematology-Oncology, University of Illinois at Chicago, 60607-7173, USA. ushalyd@uic.edu
authors.forename: L
authors.initials: L
authors.lastname: Usha
authors.forename: B
authors.initials: B
authors.lastname: Bradlow
authors.forename: W
authors.initials: W
authors.lastname: Stock
authors.forename: L C
authors.initials: LC
authors.lastname: Platanias
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology*; D018956:CD5 Antigens / Q000097:blood; D017338:Cladribine / Q000008:administration & dosage; D002999:Clone Cells / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000276:immunology* / Q000473:pathology; D008297:Male; D012074:Remission Induction
chemical_list: D018956:CD5 Antigens; D017338:Cladribine