title: Force spectroscopy with single bio-molecules.
abstract: For many biological molecules, force is an important functional and structural parameter. With the rapidly growing knowledge about the relation between structure, function, and force, single-molecule force spectroscopy has become a versatile analytical tool for the structural and functional investigation of single bio-molecules in their native environments. Within the past year, detailed insights into binding potentials of receptor ligand pairs, protein folding pathways, molecular motors, DNA mechanics and the functioning of DNA-binding agents (such as proteins and drugs), as well as the function of molecular motors, have been obtained.
authors.affiliation: Lehrstuhl für Angewandte Physik and Center for NanoScience, Ludwig-Maximilians-Universität, Amalienstrasse 54, D-80799 München, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Clausen-Schaumann
authors.forename: M
authors.initials: M
authors.lastname: Seitz
authors.forename: R
authors.initials: R
authors.lastname: Krautbauer
authors.forename: H E
authors.initials: HE
authors.lastname: Gaub
mesh_terms: D004247:DNA / Q000737:chemistry; D017510:Protein Folding; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D004247:DNA