title: Results of larynx preservation surgery for advanced laryngeal cancer through tracheal autotransplantation.
abstract: OBJECTIVE
  To evaluate the use of tracheal autotransplantation for reconstruction of the hemilaryngectomy defect that includes the hemicricoid cartilage and results from resection of laryngeal or hypopharyngeal cancer.
  
  
  METHODS
  The clinical records of 28 patients undergoing primary or salvage hemicrico-hemilaryngectomy for laryngeal (26 patients) and pyriform sinus (2 patients) cancer were analyzed for function and local control.
  
  
  METHODS
  Academic center.
  
  
  METHODS
  Case series review of 28 consecutive patients treated during a 3(1/2)-year period who had an average follow-up period of 19 months.
  
  
  METHODS
  Twenty-five men and 3 women, aged from 28 to 79 years, underwent a hemilaryngectomy that included the hemicricoid cartilage, the ipsilateral thyroid lobe, and a unilateral or bilateral lymph node dissection. In 26 patients, these extensive defects were reconstructed with a tracheal autotransplantation that restored the larynx at the glottic and subglottic levels. In 2 patients, the defect was converted into a total laryngectomy because of tumor extension beyond the resection margins of a hemicrico-hemilaryngectomy.
  
  
  METHODS
  The times to decannulation and retake of full oral feeding, the quality of speech, and the incidence and site of recurrent cancer were assessed.
  
  
  RESULTS
  Of the 26 patients undergoing tracheal autotransplantation, 24 were decannulated and all regained the ability to maintain nutrition by mouth. Ultimate voice quality was "subnormal" to "moderately hoarse" in all patients. Five recurrences developed of which 2 were treated with total laryngectomy.
  
  
  CONCLUSIONS
  Functional reconstruction of extensive laryngeal defects can be achieved with an autotransplantation of cervical trachea, with favorable functional results and acceptable morbidity. This technique expands the limits of conservation surgery for selected laryngeal and hypopharyngeal tumors.
authors.affiliation: Department of Oto-Rhino-Laryngology Head and Neck Surgery, University Hospital St Rafael, K.U. Leuven, Kapucijnenvoer 33, B-3OOO Leuven, Belgium. pierre.delaere@uz.kuleuven.ac.be
authors.forename: P R
authors.initials: PR
authors.lastname: Delaere
authors.forename: V
authors.initials: V
authors.lastname: Vander Poorten
authors.forename: C
authors.initials: C
authors.lastname: Vanclooster
authors.forename: A
authors.initials: A
authors.lastname: Goeleven
authors.forename: R
authors.initials: R
authors.lastname: Hermans
mesh_terms: D000328:Adult; D000368:Aged; D003679:Deglutition / Q000502:physiology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy; D007830:Larynx / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods*; D012119:Respiration; D014132:Trachea / Q000637:transplantation*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014831:Voice