Correlations in low-frequency BOLD fluctuations reflect cortico-cortical connections.
Cross-correlation of low-frequency temporal fluctuations (<0.08 Hz) was used to correlate widely separated anatomic regions during continuous performance of a spatial working memory task. The regions of highest correlation to right-hemisphere dorsolateral prefrontal cortex correspond to the regions of largest baseline signal change in a conventional block-style functional MRI paradigm. Additionally, it is shown that the correlations between elements of the functional network increase during performance of a task that activates the network when compared to a task that does not directly stimulate the functionally connected network.
Lowe
M J
MJ
Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Dzemidzic
M
M
Lurito
J T
JT
Mathews
V P
VP
Phillips
M D
MD
D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D011939:Mental Recall / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology