[Ulcer protective effect of melatonin during artificial simulation of desynchronization in rats].
The study was made on Wistar rats. A shift in endogenous biological rhythms was simulated by that in the light phase by 12 hours and evaluated by the shift in the rhythm of rectal temperature. Experiments revealed that desynchronization potentiated ulcerative processes in the rat stomach. The study demonstrated the protective effect of intraperitoneally injected melatonin to prevent the formation of ulcerative defects in the rat stomach during artificially simulated desynchronization.
Komarov
F I
FI
Rapoport
S I
SI
Malinovskaia
N K
NK
Sudakov
K V
KV
Sosnovskiĭ
A S
AS
Pertsov
S S
SS
Wetterberg
L
L
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D001831:Body Temperature / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008550:Melatonin / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012007:Rectum; D013276:Stomach Ulcer / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*
D000975:Antioxidants; D008550:Melatonin