[Apoptosis and pathologies of the central nervous system].
The program of cell death called apoptosis is a biochemical and genetical pathway which has been well conserved throughout evolution. In the past years, the involvement of apoptosis has been shown not only during the embryonic development of the nervous system, but also in neurodegenerative diseases. Moreover, resistance to apoptosis is clearly an important factor in tumor growth and seems to be, at least partially, a major process in chemo- and radio-resistance. In this review, we briefly describe the main molecular events of the apoptotic process, known to date, and discuss possible defects in the central nervous system diseases.
Martin
S
S
Clinique Universitaire de Neurochirurgie (Pr Y. Lajat), Hôpital Laennec, BP 1005, 44035 Nantes Cedex 01. stepaneandre.martin@chu-nantes.fr
Vallette
F
F
D000544:Alzheimer Disease / Q000209:etiology / Q000503:physiopathology; D017209:Apoptosis / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D002493:Central Nervous System Diseases / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D009410:Nerve Degeneration / Q000503:physiopathology; D010300:Parkinson Disease / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D019014:fas Receptor / Q000378:metabolism
D016159:Tumor Suppressor Protein p53; D019014:fas Receptor