title: Proton MR spectroscopic imaging without water suppression.
abstract: To improve reproducibility in proton magnetic resonance (MR) spectroscopic imaging in human brain, simultaneous acquisition of the internal water reference and metabolite signals was evaluated. Measurements in healthy volunteers showed that the increase in dynamic range from signal oversampling was sufficient to avoid digitization errors. In addition, use of singular value decomposition techniques and finite impulse response filters proved effective in separating water and metabolite signals and providing estimates of the metabolite concentrations.
authors.affiliation: Clinical Brain Disorders Branch, National Institute for Mental Health and the Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, USA. veen@nih.gov
authors.forename: J W
authors.initials: JW
authors.lastname: van Der Veen
authors.forename: D R
authors.initials: DR
authors.lastname: Weinberger
authors.forename: G
authors.initials: G
authors.lastname: Tedeschi
authors.forename: J A
authors.initials: JA
authors.lastname: Frank
authors.forename: J H
authors.initials: JH
authors.lastname: Duyn
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D011522:Protons; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted
chemical_list: D011522:Protons; D003401:Creatine; D002794:Choline