Protein sgp 120 as a marker of an acquired angioedema.
BACKGROUND
Angioedema is not an event peculiar to an acute-phase response. We registered the appearance of angioedema in four nonatopic patients suffering from diverse inflammatory stimuli.


METHODS
Serum concentrations of C-reactive protein (CRP), haptoglobin, alpha1-antitrypsin, alpha2-macroglobulin, C3, C4, C1INH and protein sgp 120 (classified as a regulatory protein of the complement system) were assessed over 7 consecutive days, beginning with the onset of angioedema in these four patients.


RESULTS
Instead of returning to the normal level, CRP peaked again on the 4th day (A-test, P<0.05) and declined significantly by the 7th day (A-test, P<0.05). Serum levels of sgp 120, C3c and C1INH increased gradually up to the 5th day but only sgp 120 was significantly raised in relation to the initial value (P< 0.05).


CONCLUSIONS
In our patients, we registered four diverse profiles of the acute-phase proteins (Kruskal-Wallis test, P<0.05) probably due to the diverse nature of the pre-existing inflammatory stimuli. According to these results, the unexpected appearance of angioedema implies the contribution of sgp 120 as the main source of fragments with kinin-like properties.
Paranos
S
S
University Medical Center Zvezdara, Belgrade, Yugoslavia. Paranos@Eunet.Yu
Nikolic
G
G
D000209:Acute-Phase Proteins / Q000378:metabolism; D000799:Angioedema / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000378:metabolism; D003172:Complement C1 / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D005260:Female; D006242:Haptoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012795:Sialoglycoproteins / Q000097:blood*; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D000209:Acute-Phase Proteins; D015415:Biomarkers; D003172:Complement C1; D003176:Complement C3; D003181:Complement C4; D006242:Haptoglobins; D012795:Sialoglycoproteins; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D002097:C-Reactive Protein