title: Comparative analysis of the Helicobacter pylori status in patients with gastric MALT-type lymphoma and their respective spouses.
abstract: Helicobacter pylori is of major importance for the development and progression of gastric MALT-type lymphoma. In case of localized low grade lymphoma successfully treated by Helicobacter pylori eradication reinfection by the bacterium may involve the risk of lymphoma reoccurrence.
  
  
  OBJECTIVE
  To assess the frequency and type of Helicobacter pylori infection among patients with gastric MALT-type lymphoma and their respective spouses as potential sources of person to person spread of the infection.
  
  
  METHODS
  35 patients with gastric MALT-type lymphoma and their cohabiting spouses.
  
  
  METHODS
  We investigated serum IgG titers in response to the infection by Helicobacter pylori and to its virulence factors CagA and VacA by enzyme linked immunosorbent assay (ELISA) and by Western blot.
  
  
  RESULTS
  Seropositivity of Helicobacter pylori, Cag A and Vac A was found to be 100/89/69% and 97/86/66% in patients and respective partners, respectively. The seroprevalence rates of the latter group by far exceed those of the German population.
  
  
  CONCLUSIONS
  These data provide evidence for a high Helicobacter pylori infection rate in both patients with gastric MALT-type lymphoma and their respective spouses. Considering the latter as a potential source of reinfection with the risk of lymphoma reoccurrence for the successfully treated patient with gastric MALT-type lymphoma careful follow-up seems highly reasonable to decide on the necessity of a future test-and-treat strategy of this population.
authors.affiliation: Medizinische Klinik II, Klinikum Aschaffenburg, Akademisches Lehrkrankenhaus, Universität Würzburg. wolfgang.fischbach@klinikum-aschaffenburg.de
authors.forename: W
authors.initials: W
authors.lastname: Fischbach
authors.forename: T
authors.initials: T
authors.lastname: Jung
authors.forename: M
authors.initials: M
authors.lastname: Goebeler-Kolve
authors.forename: M
authors.initials: M
authors.lastname: Eck
mesh_terms: D000328:Adult; D000368:Aged; D018562:Disease Transmission, Infectious; D005260:Female; D016481:Helicobacter Infections / Q000382:microbiology* / Q000635:transmission; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018454:Spouses; D013274:Stomach Neoplasms / Q000382:microbiology*; D014774:Virulence