The COP9 signalosome: from light signaling to general developmental regulation and back.
The COP9 signalosome has eight core subunits that are highly conserved between plants and animals. Some of the subunits in Arabidopsis are found in forms that are independent of the complex. The COP9 complex is essential for animal development. The COP9 signalosome may have both an evolutionary and a physical relationship with both the regulatory lid of the proteasome and eIF3.
Karniol
B
B
Department of Plant Sciences, Tel-Aviv University, Israel.
Chamovitz
D A
DA
D000075686:COP9 Signalosome Complex; D003546:Cysteine Endopeptidases / Q000378:metabolism; D008027:Light; D046911:Macromolecular Substances; D019684:Magnoliopsida / Q000378:metabolism / Q000528:radiation effects*; D009024:Morphogenesis / Q000528:radiation effects; D009097:Multienzyme Complexes / Q000378:metabolism; D046912:Multiprotein Complexes; D010447:Peptide Hydrolases; D010448:Peptide Initiation Factors / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism*; D039665:Prokaryotic Initiation Factor-3; D046988:Proteasome Endopeptidase Complex; D011485:Protein Binding; D021122:Protein Subunits; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
D046911:Macromolecular Substances; D009097:Multienzyme Complexes; D046912:Multiprotein Complexes; D010448:Peptide Initiation Factors; D010940:Plant Proteins; D039665:Prokaryotic Initiation Factor-3; D021122:Protein Subunits; D011506:Proteins; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex