Hereditary angioedema precipitated by estrogen replacement therapy in a menopausal woman.
We report the first documented case in the literature of hereditary angioedema presenting after commencement of estrogen replacement therapy for menopausal symptoms. The late presentation of the disease and the precipitation of attacks by physiological doses of estrogen replacement therapy make this a highly unusual case. The pathophysiology of hereditary angioedema and its hormonal links are discussed.
McGlinchey
P G
PG
Department of General Medicine, Royal Victoria Hospital, Belfast, Northern Ireland. paulmcglinchey@hotmail.com
McCluskey
D R
DR
D017668:Age of Onset; D000799:Angioedema / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D003174:Complement C1 Inactivator Proteins / Q000172:deficiency; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged
D003174:Complement C1 Inactivator Proteins; D004967:Estrogens