title: Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis.
abstract: Aldose reductase (AKR1B1) is the first enzyme in the polyol pathway through which glucose is converted to sorbitol, and has been implicated in the etiology of diabetic complications. However, its physiological role is still not well understood. In the kidney, AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. We report here that the mice lacking AKR1B1 showed hypercalciuria, hypercalcemia, hypermagnesemia, and reduced ability to concentrate urine, suggesting a new physiological role of AKR1B1 in divalent cation homeostasis.
authors.affiliation: Third Department of Internal Medicine, Yamanashi Medical University, Tamaho, Yamanashi, 409-3898, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Aida
authors.forename: Y
authors.initials: Y
authors.lastname: Ikegishi
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Tawata
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Onaya
mesh_terms: D000449:Aldehyde Reductase / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D015139:Blotting, Southern; D015153:Blotting, Western; D001835:Body Weight; D002118:Calcium / Q000652:urine*; D002412:Cations; D002712:Chlorides / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D017353:Gene Deletion; D015723:Gene Library; D005838:Genotype; D005947:Glucose / Q000378:metabolism; D007150:Immunohistochemistry; D007668:Kidney / Q000378:metabolism; D008274:Magnesium / Q000652:urine*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008957:Models, Genetic; D010641:Phenotype; D010710:Phosphates / Q000097:blood / Q000652:urine; D011188:Potassium / Q000097:blood / Q000652:urine; D012076:Renal Agents / Q000494:pharmacology; D012964:Sodium / Q000097:blood / Q000652:urine; D014867:Water / Q000378:metabolism; D014868:Water Deprivation
chemical_list: D001786:Blood Glucose; D002412:Cations; D002712:Chlorides; D010710:Phosphates; D012076:Renal Agents; D014867:Water; D012964:Sodium; D003404:Creatinine; D000449:Aldehyde Reductase; D003894:Deamino Arginine Vasopressin; D008274:Magnesium; D005947:Glucose; D011188:Potassium; D002118:Calcium