Correlation between cytochrome P-450 system and liver function tests during experimental liver transplantation.
The aims of this investigation are: 1) to assess the function of the hepatocyte in transplanted porcine liver, immediately after reperfusion, by monitoring both LFTs and the MEGX levels; 2) to search for correlation between MEGX and LFTS, in an effort to evaluate the metabolic mechanisms occurring in the early liver transplantation revascularization phase. The MEGX test was found to be less than 50 micrograms/ml in all the recipients and all the LFTS tested have been reported to be out the normal range. Furthermore our data has shown a statistically significant correlationship between the MEGX values and those of alkaline phosphatase and prothrombin and a highly significant correlationship with cholinesterase.
Gruttadauria
S
S
Department of Surgery, University of Catania.
Marino
G
G
Catalano
F
F
Sgroi
A V
AV
Di Mauro
G L
GL
Basile
F
F
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D022781:Hepatocytes / Q000378:metabolism*; D007430:Intraoperative Care; D008012:Lidocaine / Q000031:analogs & derivatives / Q000378:metabolism; D008111:Liver Function Tests; D016031:Liver Transplantation; D013552:Swine
D003577:Cytochrome P-450 Enzyme System; D008012:Lidocaine; C001173:monoethylglycinexylidide