The role of melanocortin receptors in sexual behavior in female rats.
Earlier data have indicated that alpha-MSH may play a role for sexual behavior in rats. In this study we investigated the effects of MSH peptides on sexual receptivity in ovariectomized-adrenalectomized female rats, pre-treated with benzoate of estradiol, in presence of vigorous male rats. The results show that alpha-MSH significantly increases lordosis behavior in female rats after injections into the ventromedial nucleus. Interestingly, we have for the first time shown that gamma-MSH also causes significant increase in lordosis in female rats. Furthermore, we show that HS014, an antagonist for the central MC receptors, in dose dependent manner blocks the effect of alpha-MSH on lordosis. The results indicate that the effects of MSH peptides on female sexual behaviour are mediated through a specific MC receptor, which could be the MC3 receptor.
Cragnolini
A
A
Laboratorio de Fisiología, Departamento de Farmacología, Faculted de Ciencias Químicas, UNC, Ciudad Universitaria, 5000 Córdoba, Argentina.
Scimonelli
T
T
Celis
M E
ME
Schiöth
H B
HB
D000315:Adrenalectomy; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D008297:Male; D008845:Microinjections; D009479:Neuropeptides / Q000494:pharmacology; D010052:Ovariectomy; D010456:Peptides, Cyclic / Q000494:pharmacology; D011187:Posture; D051381:Rats; D017208:Rats, Wistar; D018043:Receptors, Corticotropin / Q000037:antagonists & inhibitors / Q000502:physiology*; D044101:Receptors, Melanocortin; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D000521:alpha-MSH / Q000494:pharmacology*
C116941:HS014 cyclic peptide; D009479:Neuropeptides; D010456:Peptides, Cyclic; D018043:Receptors, Corticotropin; D044101:Receptors, Melanocortin; D004958:Estradiol; D000521:alpha-MSH