title: Highly enantioselective approach to indolizidines: preparation of (+)-(1S,8aS)-1-hydroxyindolizidine and (-)-slaframine.
abstract: A highly stereoselective approach to (-)-slaframine and its probable biosynthetic precursor (+)-(1S,8aS)-1-hydroxyindolizidine has been developed based on a diastereofacially selective cycloaddition of dichloroketene with a chiral dienol ether.
authors.affiliation: Université Joseph Fourier de Grenoble, Chimie Recherche (LEDSS), 38041 Grenoble Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Pourashraf
authors.forename: P
authors.initials: P
authors.lastname: Delair
authors.forename: M O
authors.initials: MO
authors.lastname: Rasmussen
authors.forename: A E
authors.initials: AE
authors.lastname: Greene
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis*; D007212:Indolizines / Q000138:chemical synthesis*; D009183:Mycotoxins / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: C416865:1-hydroxyindolizidine; D000470:Alkaloids; D007212:Indolizines; D009183:Mycotoxins; C009275:slaframine