title: Characteristics of current benzodiazepine users as indicators of differences in physical and mental health.
abstract: The relationship between characteristics of benzodiazepine exposure and health-status was examined in order to investigate risk profiles of benzodiazepine users. In the only pharmacy of a Dutch community of 13,500 inhabitants, all current benzodiazepine users that presented with a benzodiazepine prescription in November 1994 were invited to participate. On the basis of the RAND-36 questionnaire, summary scores for both physical and mental health were calculated, the Physical Component Summary (PCS) and the Mental Component Summary (MCS). After dichotomization with a cut-off point indicating seriously impaired health and after the combination of the PCS and MCS, four different categories of health status could be identified. We used logistic regression to study the relation between these four different groups with respect to benzodiazepine exposure. In total a group of 360 current benzodiazepine users was studied. Results showed that almost one-third of the participants had no significant impaired health; this group was further classified as reference group. We classified three other groups: one with physical problems (31%), one with mental problems (18%), and one with a combination of the two (22%). Multivariate analysis showed differences in risk factors for an impaired health status. The group with impaired physical health was associated with self-reported indication for muscle relaxation, hypnotic use, and a high CDS (Chronic Disease Score). The group with impaired mental health was associated with more frequent consulting of a mental health care specialist and with a low sense of self-efficacy. The group with both impaired physical as well as mental health was associated with a higher incidence of widowhood, a lower sense of self-efficacy, a high CDS, using benzodiazepines more than prescribed, and reporting depression as reason for their benzodiazepine use. In particular, two groups need critical examination: a group of apparently healthy users with long-term benzodiazepine use; and a frail group with impaired physical and mental health and using a higher dose than prescribed. Patient counseling and management of these four groups can be tailored to the specific needs of each group.
authors.affiliation: Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: van Hulten
authors.forename: K B
authors.initials: KB
authors.lastname: Teeuw
authors.forename: A B
authors.initials: AB
authors.lastname: Bakker
authors.forename: A
authors.initials: A
authors.lastname: Bakker
authors.forename: H G
authors.initials: HG
authors.lastname: Leufkens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D003430:Cross-Sectional Studies; D004363:Drug Utilization; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008603:Mental Health / Q000706:statistics & numerical data*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012044:Regression Analysis; D018570:Risk Assessment; D011795:Surveys and Questionnaires
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines