title: Plasma endothelin-1 levels and circulating endothelial cells in patients with aortoarteritis.
abstract: To investigate the correlation between plasma endothelin-1 (ET-1), circulating endothelial cells (CECs), and the disease activity in patients with aortoarteritis. In this study, radioimmunoassay was used to measure plasma levels of ET-1 in 56 patients with aortoarteritis. Circulating endothelial cell counts were also carried out as an indicator of vessel wall lesions. The plasma levels of ET-1 and CECs in the active disease patient group were significantly higher than those in inactive patient group (p<0.001). A significant positive correlation was found between plasma ET-1 levels and erythrocyte sedimentation rates (ESRs) in patients with aortoarteritis (r=0.645, p<0.001), as well as CECs (r=0.876, p<0.001). These results suggested that the ET-1 secreted during the active stages of aortoarteritis may cause constriction and proliferation of vascular smooth muscle cells, thus contributing to the pathogenesis of luminal narrowing. The increased CECs might serve as a marker of disease activity.
authors.affiliation: Division of Hypertension, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College, Beijing, P.R. China.
authors.forename: A
authors.initials: A
authors.lastname: Dang
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: P
authors.initials: P
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: D
authors.initials: D
authors.lastname: Zheng
authors.forename: Y
authors.initials: Y
authors.lastname: Ruan
authors.forename: L
authors.initials: L
authors.lastname: Liu
mesh_terms: D000328:Adult; D001025:Aortitis / Q000097:blood* / Q000175:diagnosis*; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000166:cytology*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011863:Radioimmunoassay; D012044:Regression Analysis; D012720:Severity of Illness Index
chemical_list: D019332:Endothelin-1