Cushing's syndrome in an 81-year-old patient treated with budesonide and amiodarone.
This is the first report of Cushing's syndrome under oral budesonide treatment. An 81-year-old man known for paroxysmal atrial fibrillation and chronic renal insufficiency, treated with 6 mg budesonide for collagenous colitis, developed Cushing's syndrome under co-administration of amiodarone. The Cushing's syndrome disappeared after discontinuation of the amiodarone treatment. Metabolism of the two medications by hepatic cytochrome P 450 3A may explain the development of Cushing's syndrome.
Ahle
G B
GB
Division of Gastroenterology CHUV/PMU, University Hospital, Lausanne, Switzerland.
Blum
A L
AL
Martinek
J
J
Oneta
C M
CM
Dorta
G
G
D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy; D019819:Budesonide / Q000009:adverse effects* / Q000627:therapeutic use; D003480:Cushing Syndrome / Q000139:chemically induced*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006801:Humans; D008297:Male
D000889:Anti-Arrhythmia Agents; D000893:Anti-Inflammatory Agents; D019819:Budesonide; D003577:Cytochrome P-450 Enzyme System; D000638:Amiodarone