title: Spiny keratoderma.
abstract: Spiny keratoderma is a descriptive term used to encompass a variety of unusual, disparate keratodermas. Spiny keratoderma has been associated with lipid abnormalities and has been limited to the palms and soles in some individuals. We describe an acquired case of spiny keratoderma in which an adult woman developed filiform lesions predominating on the trunk and proximal extremities. Treatment with topical emollients and keratolytic agents was unsuccessful, but topical tazarotene led to long periods of resolution. She has had no other associated abnormalities. The clinical features and differential diagnosis of spiny keratoderma are reviewed.
authors.affiliation: Department of Dermatology, Buffalo Medical Group, Williamsville, NY 14221, USA.
authors.forename: T N
authors.initials: TN
authors.lastname: Helm
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: K F
authors.initials: KF
authors.lastname: Helm
mesh_terms: D000287:Administration, Topical; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005782:Gels; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use; D007642:Keratosis / Q000188:drug therapy / Q000473:pathology*; D009539:Nicotinic Acids / Q000627:therapeutic use; D012176:Retinoids
chemical_list: D005782:Gels; D007641:Keratolytic Agents; D009539:Nicotinic Acids; C086827:tazarotene; D012176:Retinoids