[Wolfram syndrome. Urologic implications].
OBJECTIVE
We report on four new cases of Wolfram's Syndrome. We emphasize in urological aspects of this disease.


METHODS
Three male siblings. The other patient is also a male, without familiar relation with the other ones. All four patients presents different levels of urological alterations, mainly urinary collecting system dilation and decrease in detrusor muscle contractility.


CONCLUSIONS
Urological findings are cardinal aspects in Wolfram syndrome. Due to its high frequency and prognostic value in natural history of disease. Urological disease seems to be within a systemic neurological tissues affectation of etiology that remains unknown.
Anglada Curado
F J
FJ
Servicio de Urología, Hospital Regional Universitario Reina Sofía, Córdoba.
Leva Vallejo
M
M
Blanco Espinosa
A
A
Prieto Castro
R
R
Regueiro López
J C
JC
Moreno Arcas
P
P
Requena Tapia
M J
MJ
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D014570:Urologic Diseases / Q000209:etiology* / Q000235:genetics; D014929:Wolfram Syndrome / Q000150:complications* / Q000235:genetics