title: The acute effect of D-tagatose on food intake in human subjects.
abstract: A double-blind randomized crossover study was performed with nineteen normal-weight men to investigate the effect on subsequent ad libitum food intake of replacing 29 g sucrose with 29 g D-tagatose as sweetener to a breakfast meal. D-Tagatose is a malabsorbed stereoisomer of fructose with potential application as a bulk sweetener. Food intake was measured at lunch offered 4 h after the breakfast meal, during the afternoon with access to abundant snacks, and finally at a supper buffet 9 h after the breakfast. Energy intake at lunch and during the snacking period was similar after ingesting the two sugars, while it was 15% lower after ingesting D-tagatose than with sucrose at supper (P < 0.05). Gastrointestinal factors such as the osmotic effects of unabsorbed D-tagatose causing distension of the gut might have mediated the acute appetite-suppressing effect. The present paper also refers to data from a preceding study in which we observed an increased self-reported energy intake after ingestion of D-tagatose compared with sucrose which, in fact, suggests a relative hyperphagic effect of D-tagatose. However, self-reported food intake may be biased by selective under-reporting and this subsequent study with a more controlled assessment of food intake was therefore conducted. This present study did not support any hyperphagic effect of D-tagatose, but rather suggests that D-tagatose may contribute to a reduced energy intake.
authors.affiliation: Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark. bbu@kvl.dk
authors.forename: B
authors.initials: B
authors.lastname: Buemann
authors.forename: S
authors.initials: S
authors.lastname: Toubro
authors.forename: A
authors.initials: A
authors.lastname: Raben
authors.forename: J
authors.initials: J
authors.lastname: Blundell
authors.forename: A
authors.initials: A
authors.lastname: Astrup
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects*; D006601:Hexoses / Q000494:pharmacology*; D006801:Humans; D007502:Iron Chelating Agents / Q000494:pharmacology*; D008297:Male; D013549:Sweetening Agents / Q000494:pharmacology*
chemical_list: D006601:Hexoses; D007502:Iron Chelating Agents; D013549:Sweetening Agents; C030192:tagatose