A comparison of full-length glycoprotein 120 from incident HIV type 1 subtype E and B infections in Bangkok injecting drug users with prototype E and B strains that are components of a candidate vaccine.
Complete gp120 sequence information was obtained from eight persons with incident HIV-1 infections (four subtype E and four subtype B) who were part of a prospective injecting drug user (IDU) cohort in Bangkok, Thailand, during 1996-1998. The incident subtype E strains were similar to the prototype subtype E strain CM244 isolated in 1992 in northern Thailand. The incident subtype B strains displayed divergence, in both overall genetic distance and other significant gp120 characteristics, from the prototype North American subtype B strain HIV-MN. Recombinant gp120s derived from CM244 and HIV-MN strains are components of a vaccine that is undergoing phase III efficacy testing, begun in March 1999, among Bangkok area IDUs. The information presented here will be important in the evaluation of any breakthrough HIV-1 infections occurring among vaccinees during the vaccine trial and in ongoing vaccine development efforts in Thailand.
Phan
K O
KO
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Callahan
M E
ME
Vanichseni
S
S
Hu
D J
DJ
Raktham
S
S
Young
N
N
Choopanya
K
K
Mastro
T D
TD
Subbarao
S
S
D016915:AIDS Vaccines / Q000008:administration & dosage; D000595:Amino Acid Sequence; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D015658:HIV Infections / Q000517:prevention & control* / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D015819:Substance Abuse, Intravenous / Q000150:complications*; D013785:Thailand; D014611:Vaccination
D016915:AIDS Vaccines; D015699:HIV Envelope Protein gp120