Levels of interleukin (IL)-6, IL-8, and IL-1 receptor antagonist in the hepatic vein following liver surgery.
OBJECTIVE
The liver produces various cytokines, but local changes in the concentrations of these reaction products after liver surgery are unknown. We investigated the local changes of interleukin-6, interleukin-8 and interleukin-1 receptor antagonist after liver surgery.


METHODS
We determined levels of interleukin-6, interleukin-8, and interleukin-1 receptor antagonist in the hepatic vein and radial artery after liver resection in 13 patients. These cytokine levels in the portal vein were also measured in 6 patients.


RESULTS
Interleukin-6, interleukin-8, and interleukin-1 receptor antagonist levels were significantly increased during liver surgery (P < 0.05). The level of interleukin-6 was significantly lower in the hepatic vein than in the radial artery as well as in the portal vein at the end of the operation (P < 0.05, < 0.03). The level of interleukin-8 and interleukin-1 receptor antagonist was significantly higher in the hepatic vein than in the artery (P < 0.05).


CONCLUSIONS
Interleukin-6 may be taken up by the liver after liver surgery, and the difference between hepatic venous and peripheral arterial interleukin-6 levels may be an indicator of liver regeneration after liver resection. Interleukin-8 and interleukin-1 receptor antagonist appear to be produced in the remaining liver.
Ueda
T
T
Department of Anesthesiology-Resuscitology, Yamaguchi University School of Medicine, Japan.
Sakabe
T
T
Oka
M
M
Maeda
Y
Y
Nishida
M
M
Murakami
F
F
Maekawa
T
T
D000368:Aged; D004564:Electrocoagulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006498:Hepatectomy; D006499:Hepatic Artery / Q000378:metabolism*; D006503:Hepatic Veins / Q000378:metabolism*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000601:surgery*; D008297:Male; D008872:Microwaves; D008875:Middle Aged; D011169:Portal Vein / Q000378:metabolism; D017534:Radial Artery; D012795:Sialoglycoproteins / Q000097:blood*; D018709:Statistics, Nonparametric
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6; D016209:Interleukin-8; D012795:Sialoglycoproteins