Imipenem therapy for septicemic melioidosis in a child with penicillin and cephalosporin adverse reaction.
The recommended treatment for severe melioidosis is ceftazidime or a combination of ceftazidime and trimethoprim-sulfamethoxazole (TMP/SMX). Amoxicillin-clavulanate has been shown to be an effective alternative therapy. In patient who is allergic to penicillin and cephalosporin, imipenem an alternative drug may be used. We described a 10 year-old boy who was diagnosed as septicemic melioidosis and type 1 diabetes mellitus. He developed fever and rash while being given ceftazidime and TMP/SMX. The fever recurred when amoxicillin-clavulanate was administered orally. He was successfully treated with imipenem.
Lumbiganon
P
P
Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Thailand.
Panamonta
O
O
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D016470:Bacteremia / Q000150:complications / Q000188:drug therapy*; D002442:Ceftazidime / Q000009:adverse effects; D002511:Cephalosporins / Q000009:adverse effects; D002648:Child; D048909:Diabetes Complications; D004359:Drug Therapy, Combination / Q000009:adverse effects; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D008297:Male; D008554:Melioidosis / Q000150:complications / Q000188:drug therapy*; D013845:Thienamycins / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013845:Thienamycins; D015378:Imipenem; D019980:Amoxicillin-Potassium Clavulanate Combination; D002442:Ceftazidime