title: Mesenchymal dysplasia of the placenta.
abstract: A severe case of placental mesenchymal dysplasia occurred in association with intrauterine fetal death (IUFD). The gravida-1, para-1 mother was a 26-year-old Japanese. The first pregnancy was unremarkable and a healthy female infant was delivered. The present pregnancy had been uneventful until 34 weeks of gestation when IUFD was detected. The 1516-g (mean +/- SD, 2050 +/- 387 g) stillborn infant had no external abnormalities and the karyotype was 46,XX. The placenta was markedly enlarged (1050 g; mean +/- SD, 452 +/- 202 g), and approximately 80% was occupied by extraordinary enlarged villous structures with a myxoid appearance. Histologically, the dysplastic villi had myxoid stroma and a decreased number of, occasionally obliterated, fetal vessels. There was no abnormal trophoblastic proliferation. Large-sized fetal vessels in the chorionic plate frequently contained organized thrombi. This is the first case of placental mesenchymal dysplasia, which possibly lead to the IUFD.
authors.affiliation: Division of Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan. makiko-5@qb3.so-net.ne.jp
authors.forename: M
authors.initials: M
authors.lastname: Ohyama
authors.forename: T
authors.initials: T
authors.lastname: Kojyo
authors.forename: H
authors.initials: H
authors.lastname: Gotoda
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: R
authors.initials: R
authors.lastname: Ijiri
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D002824:Chorionic Villi / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D003893:Desmin / Q000378:metabolism; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006801:Humans; D008648:Mesoderm / Q000473:pathology*; D010922:Placenta Diseases / Q000378:metabolism / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000209:etiology / Q000473:pathology*; D011263:Pregnancy Trimester, Third; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D014746:Vimentin / Q000378:metabolism
chemical_list: D000199:Actins; D003893:Desmin; D014746:Vimentin