title: Cloning and gene expression of a novel human ribonucleoprotein.
abstract: This paper reports on the cloning and characterization of a novel human ribonucleoprotein, RBM8, containing a single RNA binding domain comprising the two RNP-CS and RNP-2 consensus motifs. The protein has 55% identity to a segment of a C. elegans ribonucleoprotein of unknown function. The RBM8 gene shows ubiquitous tissue expression, predominantly as a 0.9 kb transcript. An interesting feature of the RBM8 transcript is an homology of 42% in the 3' untranslated region, in the antisense orientation, to the human gonadotropin-releasing hormone receptor polypeptide. RBM8 maps to human chromosome 14 in the 14q21-q23 region.
authors.affiliation: ZymoGenetics, Inc., Seattle, WA 98102, USA. conklin@zgi.com
authors.forename: D C
authors.initials: DC
authors.lastname: Conklin
authors.forename: M W
authors.initials: MW
authors.lastname: Rixon
authors.forename: R E
authors.initials: RE
authors.lastname: Kuestner
authors.forename: M F
authors.initials: MF
authors.lastname: Maurer
authors.forename: T E
authors.initials: TE
authors.lastname: Whitmore
authors.forename: R P
authors.initials: RP
authors.lastname: Millar
mesh_terms: D000595:Amino Acid Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016601:RNA-Binding Proteins / Q000235:genetics*; D012261:Ribonucleoproteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
chemical_list: C406243:RBM8A protein, human; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins