title: Interleukin-18 (IL-18) and infectious diseases, with special emphasis on diseases induced by intracellular pathogens.
abstract: Interleukin-18 (IL-18) is a novel cytokine mainly produced by activated macrophages. IL-18 was originally called interferon-gamma inducing factor, due to its action in inducing IFN-gamma secretion from Th1 cells, NK cells and NKT cells. It has been reported that IL-18 may play important roles in various diseases including cancer and infectious diseases. This review deals with the roles of IL-18 in infectious diseases, with special emphasis on IL-18 in infectious diseases caused by intracellular pathogens including Mycobacterium tuberculosis, Mycobacterium leprae, Listeria monocytogenes and Salmonella typhimurium.
authors.affiliation: Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti-tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo 204-0022, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sugawara
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007239:Infections / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D020382:Interleukin-18 / Q000378:metabolism*; D008088:Listeriosis / Q000378:metabolism / Q000473:pathology; D009164:Mycobacterium Infections / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D012480:Salmonella Infections / Q000378:metabolism / Q000473:pathology; D014777:Virus Diseases / Q000378:metabolism / Q000382:microbiology
chemical_list: D020382:Interleukin-18