Apparent progression of acute glomerulonephritis to dense deposit disease.
One week after the diagnosis of meningococcal meningitis, an 8-year-old boy presented with acute renal failure and hypocomplementemia. A renal biopsy showed "postinfectious glomerulonephritis" and acute tubular necrosis. Hematuria, proteinuria, and low complement levels persisted, and 2 years later a follow-up renal biopsy revealed dense deposit disease. The apparent progression of postinfectious glomerulonephritis to dense deposit disease as observed in this patient has not been previously described.
Shahidi-Asl
M
M
Department of Pathology, Tulane University School of Medicine, New Orleans, Louisiana 70112-2699, USA. mshadid@mailhost.tcs.tulane.edu
Ananth
M
M
Boineau
F
F
Meleg-Smith
S
S
D000208:Acute Disease; D001706:Biopsy; D002648:Child; D018450:Disease Progression; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000473:pathology*; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron