The spatial behaviour of spike patches in the feline gastroduodenal junction in vitro.
In the isolated feline gastroduodenal region, the spatial propagation of slow waves and of individual spikes was reconstructed. Recordings were performed simultaneously from 240 extracellular electrodes positioned on the serosal surface across the junction. Results from nine experiments (22 slow waves) showed that the slow wave never propagated across the gastroduodenal region and that this block was due to the presence of a zone of quiescence caudal to the pylorus. In contrast, spikes (n=155) were able to propagate into the quiescent zone, either from the antrum (15.4%) or from the duodenum (34.0%) and occasionally, were able to propagate from one organ to the other (10.9%). However, in all cases, spike conduction was self-limited and activated a local area termed a 'patch'. The length of the patches located in the gastroduodenal region was significantly longer than in the rest of the duodenum (20.2 mm +/- 9. 7 vs. 9.5 mm +/- 3.2; P < 0.001) indicating a possible enhancement of spike propagation in this region. In conclusion, in spite of the total conduction block for slow waves, individual spikes are able to propagate across the gastroduodenal region, albeit in self-limited areas or 'patches'. These spike patches could form the building blocks for gastroduodenal coordination.
Lammers
W J
WJ
Department of Physiology, Faculty of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates. wlammers@uaeu.ac.ae
Slack
J R
JR
Stephen
B
B
Pozzan
O
O
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002415:Cats; D004386:Duodenum / Q000502:physiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D008297:Male; D011706:Pyloric Antrum / Q000502:physiology; D011708:Pylorus / Q000502:physiology; D013270:Stomach / Q000502:physiology*