Calcium signalling in endothelial cells.
Vascular endothelial cells are ubiquitous for their presence in each and every vessel and unique for their multifunctional nature. A large number of endothelial functions depend to various extents on changes in intracellular Ca(2+) concentration. Reviewed are endothelial Ca(2+) stores, Ca(2+) channels, and in-out-in Ca(2+) signalling events, from ligand-binding on the plasma membrane into depletion of intracellular Ca(2+) stores and therefrom out to transplasmalemmal Ca(2+) entry that is of prime importance for many endothelial functions. Special emphasis is placed on mechanisms regulating store-operated Ca(2+) entry including a Ca(2+) influx factor, the vesicle secretion-like model, the conformational coupling model, the membrane potential, cytochrome P450, protein tyrosine kinase, myosin light chain kinase and nitric oxide.
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Department of Internal Medicine III, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-3192, Hamamatsu, Japan.
Ohashi
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Watanabe
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D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism; D008955:Models, Cardiovascular; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism
D015220:Calcium Channels; D009569:Nitric Oxide; D015544:Inositol 1,4,5-Trisphosphate; D003577:Cytochrome P-450 Enzyme System; D011505:Protein-Tyrosine Kinases; D009219:Myosin-Light-Chain Kinase; D002118:Calcium