[Antibacterial activity of fosfomycin against the causative bacteria isolated from bacterial enteritis].
The in vitro antibacterial activities of fosfomycin (FOM) and 3 fluoroquinolones against Salmonella spp., pathogenic Escherichia coli, Campylobacter spp. and Shigella spp. were investigated. The activity upon the environmental condition in the inflammation was compared with standard condition in vitro. On standard condition, the MIC90 of tosfloxacin (TFLX), norfloxacin (NFLX) and levofloxacin (LVFX) against E. coli (77 strains), Shigella spp. (50) and Salmonella spp. (41) were < or = 0.025-0.10, 0.10, and 0.05 microgram/ml, respectively. The MIC90 of FOM against those organisms was 0.39-1.56 micrograms/ml. The MIC90 of TFLX, NFLX, LVFX against Campylobacter spp. were 6.25, 100 and 3.13 micrograms/ml, respectively. The MIC90 of FOM was 50 micrograms/ml. The activity of FOM was unaffected by pH and in anaerobic condition. On the other hand, the activity of NFLX was decreased in low pH and in anaerobic condition. In the presence of horse blood and addition of Na+, the activities of both agents were unaffected. These results suggested that FOM is equally active with or superior to fluoroquinolone in the intestinal infection treatment.
Fukuyama
M
M
Department of Microbiology, Azabu University.
Furuhata
K
K
Oonaka
K
K
Hara
T
T
Sunakawa
K
K
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D001424:Bacterial Infections / Q000382:microbiology*; D001769:Blood; D002167:Campylobacter / Q000187:drug effects* / Q000302:isolation & purification; D004573:Electrolytes / Q000494:pharmacology; D004751:Enteritis / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D019453:Escherichia coli O157 / Q000187:drug effects / Q000302:isolation & purification; D005578:Fosfomycin / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D012475:Salmonella / Q000187:drug effects* / Q000302:isolation & purification; D012760:Shigella / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004573:Electrolytes; D005578:Fosfomycin; D064704:Levofloxacin; D015242:Ofloxacin; D009643:Norfloxacin