Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen.
A new allele of the human neutrophil antigen (HNA) system (tentatively called NA2M) was discovered and its nucleotide sequence was determined. NA2M differs in a single nucleotide (193G-->A) from FCGR3B*2(NA2), resulting in an amino acid change (54Glu-->Lys). The frequency of the NA2M gene in the Japanese population was estimated to be 0.008. Granulocytes of individuals possessing NA2M reacted with HNA-1b(NA2)-specific monoclonal antibody (TAG2) in the GIFT assay.
Watanabe
Y
Y
Transfusion Information Department, Japanese Red Cross Central Blood Center, Tokyo. watanabe@cbc.jrc.or.jp
Shimada
E
E
Fujiwara
K
K
Niihara
H
H
Shimano
K
K
Mitsunaga
S
S
Tadokoro
K
K
Juji
T
T
D000483:Alleles; D000595:Amino Acid Sequence; D015703:Antigens, CD; D001483:Base Sequence; D058851:GPI-Linked Proteins; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007519:Isoantigens / Q000235:genetics*; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D017452:Receptors, IgG / Q000235:genetics*; D017385:Sequence Homology
D015703:Antigens, CD; C428200:FCGR3B protein, human; D058851:GPI-Linked Proteins; D007519:Isoantigens; D017452:Receptors, IgG; C072753:neutrophil-specific antigen NA2