title: Histopathological changes following the use of biological and synthetic glue for dural grafts: an experimental study.
abstract: Dural defects and CSF leaks are common neurosurgical problems and the search for a suitable sealant continues. The effects of such sealants on meninges and brain have not been previously studied. To study the effect of two commonly used sealants, burrholes were made in 20 rats, with the creation of dural tears which were covered with human cadaveric dura smeared with synthetic (cyanoacrylate) glue and gelatine (GRG) glue. Plain dura, placed in one of the burrholes served as a control. An intense inflammatory reaction was observed with both glues, which was found to persist till the eleventh week.
authors.affiliation: Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
authors.forename: A
authors.initials: A
authors.lastname: Varma
authors.forename: C
authors.initials: C
authors.lastname: Sarkar
mesh_terms: D000328:Adult; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D003487:Cyanoacrylates / Q000633:toxicity*; D004388:Dura Mater / Q000187:drug effects / Q000473:pathology / Q000637:transplantation*; D005780:Gelatin / Q000633:toxicity*; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008297:Male; D051381:Rats; D014014:Tissue Adhesives / Q000633:toxicity*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; D005780:Gelatin