title: Studies of MAL gene in human esophageal cancer by RNA in situ hybridization.
abstract: OBJECTIVE
  To observe the expression of MAL gene mRNA in esophageal cancer tissue and adjacent epithelial mucosa.
  
  
  METHODS
  Non-radioactive RNA in situ hybridization.
  
  
  RESULTS
  MAL gene was expressed in all epithelia of 33 matched samples but only in 8 of esophageal cancer tissues. Differential expression between esophageal cancer tissues and adjacent epithelia was not related to clinical parameters.
  
  
  CONCLUSIONS
  Down-regulation of MAL may be an important event in the development of esophageal cancer.
authors.affiliation: Department of Molecular Oncology, Institute of Cancer, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021 P.R.China. wangmr@pubem.cicams.ac.cn
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: Z
authors.initials: Z
authors.lastname: Xu
authors.forename: Y
authors.initials: Y
authors.lastname: Han
authors.forename: Y
authors.initials: Y
authors.lastname: Cai
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: M
authors.initials: M
authors.lastname: Wu
mesh_terms: D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017403:In Situ Hybridization; D026901:Membrane Transport Proteins; D009185:Myelin Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D011510:Proteolipids / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis
chemical_list: C569026:MAL protein, human; D026901:Membrane Transport Proteins; D009185:Myelin Proteins; D062806:Myelin and Lymphocyte-Associated Proteolipid Proteins; D011510:Proteolipids; D012333:RNA, Messenger