title: Evaluation of alkali metal binding selectivities of caged aza-crown ether ligands by microelectrospray ionization/quadrupole ion trap mass spectrometry
abstract: Microelectrospray ionization mass spectrometry (MESI-MS) is used to evaluate alkali metal binding selectivities of a variety of macrocyclic compounds. Well-studied crown ethers are used to validate the MESI-MS method. A quantitative correlation between MESI mass spectral ion intensities and solution equilibrium distributions of complexes is obtained for the mixtures containing a single host and different alkali metal guest ions. The MESI-MS method is successfully applied for the determination of the alkali metal binding selectivities of a series of cage-functionalized aza-crown ethers and relevant model compounds in methanol and chloroform solutions. The binding selectivities parallel previous results obtained using conventional spectrophotometric extraction methods. Structural differences in the host compounds, such as the presence of a cage functionality, binding cavity size, and overall flexibility, cause significant changes in the binding selectivities.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, 78712, USA.
authors.initials: SM
authors.lastname: Blair
authors.initials: JS
authors.lastname: Brodbelt
authors.initials: AP
authors.lastname: Marchand
authors.initials: HS
authors.lastname: Chong
authors.initials: S
authors.lastname: Alihodzic