[Bacteriology and pathogenicity of Helicobacter pylori].
Helicobacter pylori is the prototype of bacteria belonging to a new genus, the Helicobacter genus. It is a gram-negative, highly motile and microaerophilic bacterium, with a spiral shape, that colonizes the human gastric mucosa and causes several gastroduodenal diseases. Pathogenicity of H. pylori relies upon its capacity to adapt to a hostile environment and to escape the host response. Resistance to acidity, motility, adhesion, molecular mimicry, resistance to phagocytosis, synthesis of a cytotoxin, induction of an inflammatory response are the major strategies developed by H. pylori to colonize persistently and damage gastric tissue.
Skouloubris
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Unité de pathogénie bactérienne des muqueuses Institut Pasteur, Paris. sskoulou@pasteur.fr
De Reuse
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Labigne
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D002470:Cell Survival; D003603:Cytotoxins / Q000096:biosynthesis; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010587:Phagocytosis; D013270:Stomach / Q000502:physiology*
D003603:Cytotoxins