Endocapillary proliferative glomerulonephritis in a patient with parvovirus B19 infection.
A 45-year-old woman developed acute nephritic syndrome after erythema infectiosum. Laboratory data on admission showed decreased serum C3, C4, and CH50 levels and the presence of both immunoglobulin (Ig) M and IgG antibodies to human parvovirus B19 (HPV). A renal biopsy showed diffuse endocapillary proliferative glomerulonephritis. Immunofluorescence microscopy indicated 2+ granular staining for IgG, IgM, and C3 over the mesangial area and along glomerular capillary walls. HPV antigen was also detected in glomeruli by immunohistochemistry. Electron microscopy showed electron-dense deposits in the subendothelial space and the paramesangial area. These findings suggest that immune complex-type glomerulonephritis is caused by glomerular deposition of HPV antigen-antibody complexes in some patients with HPV infection.
Komatsuda
A
A
Third Department of Internal Medicine, Akita University School of Medicine, and the Department of Internal Medicine, Senboku General Hospital, Akita, Japan.komatsud@med.akita-u.ac.jp
Ohtani
H
H
Nimura
T
T
Yamaguchi
A
A
Wakui
H
H
Imai
H
H
Miura
A B
AB
D000936:Antigen-Antibody Complex; D000956:Antigens, Viral / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D016731:Erythema Infectiosum / Q000150:complications* / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000276:immunology; D016732:Parvovirus B19, Human / Q000276:immunology
D000936:Antigen-Antibody Complex; D000956:Antigens, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003165:Complement System Proteins