[Effect of beditine on the cerebral circulation and various metabolic parameters].
Beditin, or 2-(2-amino-4-thiazolyl)-1,4-benzodioxane hydrochloride, is a new benzodioxane derivative possessing antihypoxant and alpha 2-adrenoreceptor blocker properties. In contrast to idazoxan, a well-known alpha 2-adrenoreceptor blocker, beditin (3 mg/kg) significantly increases the circulation rate and decreases the blood vessel resistance in various brain structures of rats and cats without considerably changing their systemic hemodynamic indices. Upon a one-side ligation of the common carotid artery in rats, beditin prevented a sharp increase in the lactate dehydrogenase activity and a growth in the content of free ammonia in the brain, which are characteristic of the ischemic states. The ammonia-eliminating effect of beditin is related to an increase in the glutamate dehydrogenase activity in the reductive amination reaction.
Mirzoian
S A
SA
Laboratory of Pharmacology of the Cardiovascular System, National Academy of Sciences of the Republic of Armenia, Erevan, Armenia.
Petrosian
A A
AA
Arutiunian
S A
SA
Gukasian
T G
TG
Medvedev
O S
OS
Shirinian
E A
EA
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001921:Brain / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004146:Dioxanes / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D000860:Hypoxia / Q000517:prevention & control; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects*; D012867:Skin / Q000098:blood supply / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D018341:Receptors, Adrenergic, alpha-2; D013844:Thiazoles; C107649:beditine; D007770:L-Lactate Dehydrogenase; D005969:Glutamate Dehydrogenase