title: Atypical endometriosis revisited: clinical and biochemical evaluation of the different forms of superficial implants.
abstract: OBJECTIVE
  To investigate the activity of different forms of endometriosis implants by clinical and biochemical evaluation.
  
  
  METHODS
  Prospective, blinded study.
  
  
  METHODS
  Tertiary-care university hospital.
  
  
  METHODS
  Forty-seven infertile patients with minimal or mild endometriosis diagnosed at laparoscopy were included in the clinical investigation.
  
  
  METHODS
  Patients were submitted to a preoperative evaluation of endometriosis-associated dysmenorrhea by means of a 10-point linear analog scale and to laparoscopic staging of endometriosis following a current classification system. In the biochemical investigation, tissue samples from different endometriosis lesions and control tissues were assessed for prostaglandin (PG) F(2 alpha) production.
  
  
  METHODS
  Evaluation of the correlation between endometriosis-associated dysmenorrhea and the extent of the disease. Evaluation of the production of PGF(2 alpha) by the different tissues sampled.
  
  
  RESULTS
  No positive correlation was present between any of the implant subgroups and the associated dysmenorrhea. White peritoneal implants were associated with milder pain symptoms than black or red lesions. The biologic activity of red and black superficial implants, expressed as the production of PGF(2 alpha), was similar.
  
  
  CONCLUSIONS
  No positive correlation was demonstrated between endometriosis-associated dysmenorrhea and the current classification of endometriosis, which includes characterization of the different morphologic aspects of superficial endometriosis implants.
authors.affiliation: Department of Obstetrics and Gynecology, Libera Università Campus Bio-Medico, Rome, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Muzii
authors.forename: R
authors.initials: R
authors.lastname: Marana
authors.forename: L
authors.initials: L
authors.lastname: Brunetti
authors.forename: G
authors.initials: G
authors.lastname: Orlando
authors.forename: B
authors.initials: B
authors.lastname: Michelotto
authors.forename: P
authors.initials: P
authors.lastname: Benedetti Panici
mesh_terms: D000328:Adult; D015237:Dinoprost / Q000096:biosynthesis; D004412:Dysmenorrhea / Q000209:etiology; D004715:Endometriosis / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D010535:Laparoscopy; D017699:Pelvic Pain; D011300:Preoperative Care; D011446:Prospective Studies
chemical_list: D015237:Dinoprost