A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo.
We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both membrane-bound and soluble forms are produced. Naïve CD8 T cells, natural killer T cells and a subset of memory CD4 T cells bind CXCL16, and activated T cells migrated chemotactically to the soluble chemokine. By expression cloning, Bonzo (also known as STRL33 and TYMSTR) was identified as a CXCL16 receptor. CXCL16 may function in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp. CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking.
Matloubian
M
M
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA.
David
A
A
Engel
S
S
Ryan
J E
JE
Cyster
J G
JG
D000595:Amino Acid Sequence; D000818:Animals; D000075743:Chemokine CXCL16; D054427:Chemokine CXCL6; D019743:Chemokines, CXC / Q000235:genetics / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D000075744:Receptors, CXCR6; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000235:genetics / Q000276:immunology*; D043562:Receptors, G-Protein-Coupled; D015728:Receptors, HIV / Q000235:genetics / Q000276:immunology*; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D011991:Receptors, Virus; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
C423727:CXCL16 protein, human; C106330:CXCR6 protein, human; D000075743:Chemokine CXCL16; D054427:Chemokine CXCL6; D019743:Chemokines, CXC; C498926:Cxcl16 protein, mouse; D008024:Ligands; D008565:Membrane Proteins; D000075744:Receptors, CXCR6; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D043562:Receptors, G-Protein-Coupled; D015728:Receptors, HIV; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D011991:Receptors, Virus