Decreased locomotor activity in mice carrying transgenic Fyn tyrosine kinase.
We found that mice carrying constitutively active Fyn tyrosine kinase show low levels of spontaneous locomotor activity and that this activity increases when the mice are treated with the NMDA receptor antagonist MK-801. These findings indicate that the tyrosine phosphorylation of the NMDA receptors by Fyn participates in the control of locomotor activity.
Ishibashi
H
H
Department of Physiological Sciences, Graduate University for Advanced Studies, Myodaiji, Okazaki, 444-8585, Japan. ishibashi.cnb@tmd.ac.jp
Kojima
N
N
Obata
K
K
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D009043:Motor Activity / Q000235:genetics* / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D051076:Proto-Oncogene Proteins c-fyn; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology
D011518:Proto-Oncogene Proteins; D016194:Receptors, N-Methyl-D-Aspartate; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn