title: Tubulocystic clear cell adenocarcinoma arising within the prostate.
abstract: Neoplasms resembling ovarian common epithelial-type tumors, including clear cell adenocarcinomas, rarely occur in the lower urinary tract of men. When they do, they develop in the urethra or urinary bladder. We report a case of such a tumor arising within the prostate of a 47-year-old man. The tumor was a cystic mass in the left posterolateral region of the prostate. Histologically, the tumor was chiefly composed of tubulocystic and papillary glands lined by glycogen-rich, cuboidal or hobnail cells with clear to eosinophilic cytoplasm. The tumor cells were strongly positive for pan-cytokeratin, low molecular weight cytokeratin, and epithelial membrane antigen, and focally positive for high molecular weight keratin. The tumor did not immunohistochemically express prostate-specific antigen (PSA) and prostatic acid phosphatase. Serologically, the patient had increased levels of CA125 instead of PSA. The clinical as well as the pathologic features are consistent with a clear cell adenocarcinoma as seen in the female genital tract rather than a typical prostatic adenocarcinoma.
authors.affiliation: Department of Pathology, National Yang-Ming University and Veterans General-Hospital-Tapiei, Taiwan, ROC. ccpan@vghtpe.gov.tw
authors.forename: C C
authors.initials: CC
authors.lastname: Pan
authors.forename: H
authors.initials: H
authors.lastname: Chiang
authors.forename: Y H
authors.initials: YH
authors.lastname: Chang
authors.forename: J I
authors.initials: JI
authors.lastname: Epstein
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D005472:Fluorouracil; D008727:Methotrexate