title: Sacral neuromodulation for women with Fowler's syndrome.
abstract: Neuromodulation of the sacral nerves has been found to be an effective therapy for a variety of lower urinary tract dysfunctions. The reported success rate for the period of trial stimulation (peripheral nerve evaluation test) prior to permanent implantation of a sacral nerve stimulator is variable, but generally reported to be in the region of 30-50%. We present here the results of the peripheral nerve evaluation test in 38 patients with urinary retention. 34 of the 38 had been found to have an abnormality of their striated urethral sphincter on electromyography using a concentric needle electrode, i.e., they had the disorder which was described by Fowler and coworkers in 1988. The overall success rate in this group was 68%. We believe that our relatively high success rate is due to sacral neuromodulation working via a mechanism which involves the urethral sphincter, an abnormality which had been demonstrated in 89% of these patients. Twelve of the patients subsequently underwent permanent implantation of a sacral nerve stimulator, and all of them have experienced a return of voiding. However, in 2 patients, there is a persisting need for self-catheterization. There is, however, a high reoperation rate.
authors.affiliation: Department of Uroneurology, National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Swinn
authors.forename: N D
authors.initials: ND
authors.lastname: Kitchen
authors.forename: R J
authors.initials: RJ
authors.lastname: Goodwin
authors.forename: C J
authors.initials: CJ
authors.lastname: Fowler
mesh_terms: D000293:Adolescent; D000328:Adult; D004599:Electric Stimulation Therapy; D004576:Electromyography; D005260:Female; D006801:Humans; D008160:Lumbosacral Plexus; D008875:Middle Aged; D012074:Remission Induction; D013577:Syndrome; D014521:Urethra / Q000503:physiopathology; D016055:Urinary Retention / Q000503:physiopathology / Q000628:therapy*