title: Treatment of acute strangulated internal hemorrhoids by topical application of isosorbide dinitrate ointment.
abstract: Exogenous nitric oxide has been shown useful in decreasing the internal anal sphincter tone. This study investigated the role of isosorbide dinitrate in the treatment of patients with acute strangulated internal hemorrhoids, thereby avoiding the risk of continence disturbances following conventional surgical treatment. Four male patients (median age 35 years, range 30-42) with acute strangulated hemorrhoids were treated with 1% isosorbide dinitrate. The ointment was applied to the anoderm. This application was repeated every 3 h during daytime for 2 weeks. Significant pain relief was achieved within 1 day, while transient mild headache was experienced during the first 2 days. Within 1 week the hemorrhoids became reducible. Thereafter the hemorrhoids could be treated adequately by rubber band ligation. The alternative treatment of patients with acute strangulation of prolapsed internal hemorrhoids is effective. This nonsurgical, i.e., reversible reduction of sphincter tone is an attractive alternative.
authors.affiliation: Department of Surgery, University Hospital Dijkzigt, Rotterdam, The Netherlands. briel@hlkd.azr.nl
authors.forename: J W
authors.initials: JW
authors.lastname: Briel
authors.forename: D D
authors.initials: DD
authors.lastname: Zimmerman
authors.forename: W R
authors.initials: WR
authors.lastname: Schouten
mesh_terms: D000208:Acute Disease; D000328:Adult; D006484:Hemorrhoids / Q000188:drug therapy*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D008297:Male; D009824:Ointments; D013997:Time Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D009824:Ointments; D014665:Vasodilator Agents; D007548:Isosorbide Dinitrate