Modular evolution of the purine biosynthetic pathway.
Structural studies, sequence alignments, and biochemistry have provided new insights into the evolution of the purine biosynthetic pathway. The importance of chemistry, the binding of ribose 5-phosphate (common to all purine biosynthetic intermediates), and transient protein-protein interactions in channeling of chemically unstable intermediates have all been examined in the past few years.
Kappock
T J
TJ
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue 18-409, Cambridge, MA 02139, USA. kappock@wuchem.wustl.edu
Ealick
S E
SE
Stubbe
J
J
D019143:Evolution, Molecular; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry; D011687:Purines / Q000096:biosynthesis* / Q000737:chemistry
D011506:Proteins; D011687:Purines