Novel total synthesis of the anticancer natural product dysidiolide.
The marine natural product dysidiolide has been synthesized in a highly diastereoselective fashion that features the sequential transfer of chirality from a cyclohexenone precursor.
Demeke
D
D
Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Forsyth
C J
CJ
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D017027:Protein Tyrosine Phosphatases; C121906:dysidiolide; D015107:4-Butyrolactone