title: [Prions, infections and confusions in the "transmissible" spongiform encephalopathies. The other evidence-based science. III. Review].
abstract: There are some neurological disorders with a pathological hallmark called spongiosis which include Creutzfeld-Jakob disease and its new variant, the Gertsmann-Straussler-Scheinker Syndrome and the Fatal Familial Insomnia in humans; and Scrapie and Bovine Spongiform Encephalopathy, among others, in animals. The etiological agent has been considered either transmissible or hereditary or both. Curiously, this agent has no nucleic acids, is impossible to filter, is resistant to inactivation by chemical means, has not been cultured and is unobservable at electron microscopy. All of these facts have led to some researches to claim that these agents are similar to viruses appearing in computers. However, after almost fifty years of research, is still not possible to explain why and how such elements produce the diseases commented about. On the contrary, during these years have been possible to know that these entities called slow viral infections, transmissible amyloidosis, transmissible dementia, transmissible spongiform encephalopathies or prion diseases appear in individuals with genetical predispositions exposed to several worldwide immunological stressors. The possibility that prions are the consequence and not the cause of these diseases in animals and man is day by day more reliable, and supports the suggestion that a systematic intoxication due to pesticides as well as mycotoxin ingestion, produced mainly by different molds such as Aspergillus, Penicillium or Fusarium, seem to be the true etiology of these neurodegenerative disorders.
authors.affiliation: Departamento de Medicina Interna y Ciencias Básicas Medicas, Universidad Industrial de Santander, Colombia. feleones@uis.edu.co
authors.forename: F E
authors.initials: FE
authors.lastname: León-S
authors.forename: C I
authors.initials: CI
authors.lastname: Rodriguez
authors.forename: D G
authors.initials: DG
authors.lastname: Prada
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002417:Cattle; D002648:Child; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis / Q000209:etiology; D003937:Diagnosis, Differential; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis / Q000635:transmission; D005260:Female; D016098:Gerstmann-Straussler-Scheinker Disease / Q000175:diagnosis / Q000209:etiology; D006041:Goats; D006801:Humans; D007729:Kuru / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008875:Middle Aged; D017096:Prion Diseases / Q000175:diagnosis / Q000209:etiology; D011328:Prions; D012106:Research; D012756:Sheep; D012757:Sheep Diseases / Q000635:transmission; D007319:Sleep Initiation and Maintenance Disorders / Q000235:genetics; D012897:Slow Virus Diseases / Q000175:diagnosis / Q000209:etiology
chemical_list: D011328:Prions