title: Synthesis of carbapenam skeletons using a ruthenium-catalyzed cyclization.
abstract: Carbapenam is a very important skeleton of beta-lactam antibiotics, and it has a highly strained structure. When enynes 9 were treated with RuH(2)CO(PPh(3))(3) (10 mol %) in toluene upon heating, carbapenams 10 were obtained in good yields.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. mori@pharm.hokudai.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Kozawa
authors.forename: M
authors.initials: M
authors.lastname: Nishida
authors.forename: M
authors.initials: M
authors.lastname: Kanamaru
authors.forename: K
authors.initials: K
authors.lastname: Onozuka
authors.forename: M
authors.initials: M
authors.lastname: Takimoto
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D015780:Carbapenems / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D012428:Ruthenium
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D012428:Ruthenium