Isoniazid prophylaxis in lung transplantation.
The incidence of tuberculous disease (TD) is higher in lung-transplant patients than in the general population. During a 7-year period, we included 61 patients who underwent lung transplantation in a prospective isoniazid prophylaxis protocol. Isoniazid was prescribed to infected and anergic patients not previously treated when added to the waiting list. Six of 61 patients (10%) developed tuberculosis. We observed no differences in tuberculous disease incidence between infected-anergic and non-infected patients. In our tuberculous-endemic area, isoniazid prophylaxis is safe and offers protection from TD to infected and anergic patients who must be enrolled in a lung transplantation program.
Roman
A
A
Servei de Pneumologia, Hospital General Vall d'Hebron, Barcelona, Spain. aroman@hg.vhebron.es
Bravo
C
C
Levy
G
G
Monforte
V
V
Vidal
R
R
Solé
J
J
Maestre
J
J
Morell
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use*; D006801:Humans; D006968:Hypersensitivity, Delayed; D007538:Isoniazid / Q000627:therapeutic use*; D016040:Lung Transplantation / Q000276:immunology; D008875:Middle Aged; D011446:Prospective Studies; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000517:prevention & control*
D000995:Antitubercular Agents; D007538:Isoniazid