title: Effects of collagenolytic protease preparations from invertebrates on the immune system.
abstract: We studied the effects of an active ingredient of new enzyme preparations containing collagenolytic proteases from various hydrobionts (Collagenase from hydrobionts, Polycollagenase-K, and Fermenkol). These substances in therapeutic doses did not affect the humoral immune response estimated by hemagglutination and local hemolysis in gel and caused no local irritation and allergic reactions after long-term application to the skin.
authors.affiliation: St. Petersburg Technology, St. Petersburg. public@tech.spb.ru
authors.forename: B A
authors.initials: BA
authors.lastname: Paramonov
authors.forename: O A
authors.initials: OA
authors.lastname: Klimova
authors.forename: V Y
authors.initials: VY
authors.lastname: Chebotarev
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003386:Brachyura; D003094:Collagen; D006168:Guinea Pigs; D006384:Hemagglutination / Q000187:drug effects*; D006462:Hemolytic Plaque Technique; D007274:Injections, Intraperitoneal; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D012697:Serine Endopeptidases / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D003094:Collagen; D012697:Serine Endopeptidases