title: Acute respiratory distress syndrome: resource use and outcomes in 1985 and 1995, trends in mortality and comorbidities.
abstract: OBJECTIVE
  The purpose of this study was to compare resource consumption and mortality between (ARDS) patients with adult respiratory distress syndrome treated at our center in 1985 (45 patients) and those treated in 1995.
  
  
  METHODS
  This was a retrospective observational study, considering trauma and nontrauma ARDS separately. We recorded severity index scores (APACHE III), infectious complications and multiorgan failure, intensive care unit (ICU) resource consumption (TISS 28), length of stay, time on mechanical ventilation, and ICU mortality.
  
  
  RESULTS
  We found no variation in overall ARDS mortality and no reduction in mortality in the ARDS trauma group (43.5% in 1985 vs. 38.5% in 1995, not significant) but a significant increase in mortality among nontrauma septic ARDS patients (68.2% vs. 82.9%, P < .001), largely attributable to the new comorbidities of human immunodeficiency virus (HIV) infection and hematologic malignancy. TISS-28 showed an overall reduction over this time period (49.7 +/- 6.6 vs. 38.3 +/- 9.7, P < .001), due to fewer monitoring measures, particularly a lower use of pulmonary artery catheter. There were no overall changes in length of stay or days on mechanical ventilation between 1985 and 1995, but these variables did increase among the trauma subgroup.
  
  
  CONCLUSIONS
  In our setting, mortality remained constant from 1985 to 1995 among ARDS trauma patients but not among nontrauma ARDS patients because of the new case-mix of the latter population, which now includes HIV and other immunodepressed patients.
authors.affiliation: Critical Care and Emergency Department, Virgen de las Nieves University Hospital, Granada, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: Pola
authors.forename: P
authors.initials: P
authors.lastname: Navarrete-Navarro
authors.forename: R
authors.initials: R
authors.lastname: Rivera
authors.forename: E
authors.initials: E
authors.lastname: Fernández-Mondejar
authors.forename: B
authors.initials: B
authors.lastname: Hurtado
authors.forename: G
authors.initials: G
authors.lastname: Vázquez-Mata
mesh_terms: D018806:APACHE; D015897:Comorbidity; D003953:Diagnosis-Related Groups; D005260:Female; D006295:Health Resources / Q000706:statistics & numerical data*; D017052:Hospital Mortality / Q000639:trends*; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017063:Outcome Assessment, Health Care; D012121:Respiration, Artificial / Q000706:statistics & numerical data; D012128:Respiratory Distress Syndrome / Q000453:epidemiology / Q000401:mortality* / Q000628:therapy*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D016019:Survival Analysis