Semi-interpenetrating polymer networks composed of biocompatible phospholipid polymer and segmented polyurethane.
2-Methacryloyloxyethyl phosphorylcholine (MPC) polymers, which have excellent biocompatibility, have been receiving increasing attention in biomedical and bioengineering fields; however, the mechanical strength of the hydrated MPC polymers is not sufficient for use in these fields as a bulk material. Therefore, we hypothesized that a novel material might be realized by reinforcing the MPC polymer network with segmented polyurethane (SPU). Semi-interpenetrating polymer networks (IPNs) composed of crosslinked MPC polymer and SPU were prepared. The mechanical properties of the IPN membrane were significantly improved compared with those of the MPC polymer membrane. Three-dimensional polymer networks of the MPC polymer in the IPNs were observed after solvent extraction of SPU. An X-ray photoelectron spectrum analysis revealed that the MPC units were exposed on the IPN surface. When the IPN was alternately soaked in water and ethanol, the swelling ratio was found to be completely reversible and no disintegration of the network structure was observed. The permeation coefficient of 1, 4-di(2-hydroxyethoxy)benzene through the IPN membrane was 1.11 x 10(-7) cm(-2)s(-1). The amount of adsorbed protein and the number of adherent platelets on the IPN membrane were effectively reduced compared with those on SPU. We concluded that IPNs composed of the MPC polymer and SPU are a new bulk biomaterial, which possesses both blood compatibility and good mechanical properties.
Iwasaki
Y
Y
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10, Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.yasu@i-mde.tmd.ac.jp
Aiba
Y
Y
Morimoto
N
N
Nakabayashi
N
N
Ishihara
K
K
D000042:Absorption; D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001704:Biopolymers / Q000737:chemistry*; D005340:Fibrinogen; D020100:Hydrogels / Q000737:chemistry; D008422:Materials Testing; D008567:Membranes, Artificial; D008689:Methacrylates / Q000737:chemistry*; D008854:Microscopy, Electron; D015394:Molecular Structure; D010539:Permeability; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D010973:Platelet Adhesiveness; D011109:Polymethacrylic Acids; D011140:Polyurethanes / Q000737:chemistry*; D011817:Rabbits; D013057:Spectrum Analysis; D013499:Surface Properties; D013718:Tensile Strength; D017155:Wettability; D014965:X-Rays
D001672:Biocompatible Materials; D001704:Biopolymers; D020100:Hydrogels; D008567:Membranes, Artificial; D008689:Methacrylates; D011109:Polymethacrylic Acids; D011140:Polyurethanes; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; D005340:Fibrinogen