[Antioxidant therapy with xymedon of patients with chronic osteomyelitis].
An investigation of the antioxidant activity of blood plasma allowed a conclusion to be made of an alteration of the free radical processes in patients with chronic osteomyelitis. Experimental data on the influence of the antioxidants Xymedon and Methyluracil on the main free radicals, lipid peroxidation and chemiluminescence of peritoneal macrophages of rats allowed the substantiation of using the medicines in the complex treatment of patients in the pre- and postoperative periods. As a result, in 25 patients Xymedon improved the blood indices, increased antioxidant activity of plasma and reduced the amount of recurrences of the disease as compared with the patients taking Methyluracil.
Malyshev
K V
KV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002908:Chronic Disease; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation; D008962:Models, Theoretical; D010019:Osteomyelitis / Q000188:drug therapy* / Q000601:surgery; D011182:Postoperative Care; D011300:Preoperative Care; D011743:Pyrimidines / Q000627:therapeutic use*; D051381:Rats; D012008:Recurrence; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D005609:Free Radicals; D011743:Pyrimidines; C069705:xymedon; D014498:Uracil; C008378:6-methyluracil