title: Measurements of cortical cellular pH by intracranial tonometer in severe head injury.
abstract: OBJECTIVE
  To evaluate the cortical cellular damage in acute severe head injury, we measured the cortical cellular pH by using an intracranial tonometer made in our institution.
  
  
  METHODS
  Prospective, 3.5-yr data collection.
  
  
  METHODS
  University hospital trauma intensive care unit.
  
  
  METHODS
  Severely head-injured patients (n = 29) with Glasgow Coma Scale score <8.
  
  
  METHODS
  Routine emergency neurologic procedure.
  
  
  RESULTS
  We made 98 measurements of cortical cellular pH by intracranial tonometer in 29 severely head-injured patients in the acute phase. Each patient's intracranial pressure was recorded, and in 16 patients, the saturation of jugular venous oxygen was monitored. The outcome at 6 months after injury was significantly better in patients having a cortical cellular pH of >7.2 than those with <7.2. The cerebral perfusion pressure and cortical cellular pH correlated significantly (p < .0001).
  
  
  CONCLUSIONS
  Our study suggests the usefulness of measurement of cortical cellular pH by intracranial tonometer for evaluating the severity of focal anaerobic cerebral metabolism and predicting patient prognosis.
authors.affiliation: Department of Emergency and Critical Care Medicine, Tama-Nagayama Hospital, Nippon Medical School, Tama-city, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yokota
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Naoe
authors.forename: A
authors.initials: A
authors.lastname: Fuse
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Unemoto
authors.forename: A
authors.initials: A
authors.lastname: Kurokawa
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D002545:Brain Ischemia / Q000175:diagnosis / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003422:Critical Care; D005260:Female; D016489:Head Injuries, Closed / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies
chemical_list: D010100:Oxygen