Neuroblastomatous recurrence of ganglioglioma. Case report.
This case is believed to be the first reported recurrent intracranial ganglioglioma with purely neuroblastomatous malignant transformation. A complete macroscopic resection of a right frontal lobe tumor in an 18-year-old woman revealed differentiated ganglioglioma. Seven years later a large, well-demarcated recurrent tumor was again macroscopically totally resected in the same patient. Histological analysis showed malignant transformation in only the neuronal component of the original tumor. A review of the literature on recurrent gangliogliomas and their malignant transformation is included.
David
K M
KM
Department of Neurosurgery, Charing Cross Hospital, London, United Kingdom. KMDavid@btinternet.com
de Sanctis
S
S
Lewis
P D
PD
Noury
A M
AM
Edwards
J M
JM
D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D005260:Female; D018303:Ganglioglioma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery; D009447:Neuroblastoma / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed