title: Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans.
authors.affiliation: Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, MD 20851, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Lesko
authors.forename: M
authors.initials: M
authors.lastname: Rowland
authors.forename: C C
authors.initials: CC
authors.lastname: Peck
authors.forename: T F
authors.initials: TF
authors.lastname: Blaschke
authors.forename: D
authors.initials: D
authors.lastname: Breimer
authors.forename: H J
authors.initials: HJ
authors.lastname: de Jong
authors.forename: A
authors.initials: A
authors.lastname: Grahnen
authors.forename: J J
authors.initials: JJ
authors.lastname: Kuhlmann
authors.forename: B
authors.initials: B
authors.lastname: Stewart
mesh_terms: D000818:Animals; D001702:Biopharmaceutics / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002986:Clinical Trials as Topic / Q000379:methods; D003198:Computer Simulation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D010601:Pharmacology, Clinical / Q000379:methods