RNA polymerase II elongation through chromatin.
The machinery that transcribes protein-coding genes in eukaryotic cells must contend with repressive chromatin structures in order to find its target DNA sequences. Diverse arrays of proteins modify the structure of chromatin at gene promoters to help transcriptional regulatory proteins access their DNA recognition sites. The way in which disruption of chromatin structure at a promoter is transmitted through a whole gene has not been defined. Recent breakthroughs suggest that the passage of an RNA polymerase through a gene is coupled to mechanisms that propagate the breakdown of chromatin.
Orphanides
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Zeneca Central Toxicology Laboratory, Alderley Park, Cheshire, UK.
Reinberg
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D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D005544:Forecasting; D006657:Histones / Q000378:metabolism; D009707:Nucleosomes / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000378:metabolism*; D014158:Transcription, Genetic
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D012319:RNA Polymerase II