Effects of nigrostriatal dopamine denervation on ionotropic glutamate receptors in rat caudate-putamen.
Changes in ionotropic glutamate NMDA, AMPA and KA receptor binding in rat caudate-putamen were examined by quantitative in vitro receptor autoradiography 5 weeks after lesioning nigrostriatal dopaminergic projections. In this animal model of Parkinson's disease, density of binding in caudate-putamen increased at KA, but not NMDA or AMPA receptors. The findings indicate that nigrostriatal dopamine denervation can selectively enhance KA receptor levels in rat basal ganglia, suggest that KA receptors contribute to the pathophysiology of Parkinson's disease, and may suggest innovative treatments.
Tarazi
F I
FI
Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02478, USA. ftarazi@hms.harvard.edu
Zhang
K
K
Baldessarini
R J
RJ
D018663:Adrenergic Agents; D000818:Animals; D002421:Caudate Nucleus / Q000378:metabolism*; D003714:Denervation; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000378:metabolism; D011699:Putamen / Q000378:metabolism*; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism*; D018092:Kainic Acid Receptors / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D020955:Striatonigral Degeneration / Q000139:chemically induced / Q000378:metabolism*
D018663:Adrenergic Agents; D016627:Oxidopamine; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate