title: The nonimmobilizer 1,2-dichlorohexafluorocyclobutane does not affect thermoregulation in the rat.
abstract: Inhaled and other anesthetics profoundly affect the central nervous system, causing amnesia, immobility in the face of noxious stimulation, and depression of thermoregulation. Nonimmobilizers, inhaled compounds whose lipophilicity suggests that they should be anesthetics, do not produce immobility, but they do cause amnesia. Their effects on thermoregulation were the subject of the present study. We gave eight rats isoflurane on one occasion and the nonimmobilizer 2N (1,2-dichlorolhexafluorocyclobutane) on another. We measured the effect of various concentrations of each compound on thermoregulation provoked by body cooling. The specific outcome was increased metabolism, as reflected in increased output of carbon dioxide. Isoflurane decreased the temperature threshold for such increases and the maximum response intensity, doing so in a concentration-dependent manner, whereas 2N had a minimal or no effect at any concentration up to 0.9 minimum alveolar concentration (estimated from its lipophilicity). Thus, 2N may be a useful tool for studies of the mechanisms mediating the thermoregulatory depression produced by anesthetics: 2N should not affect such a mechanism.
authors.affiliation: Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0464, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Maurer
authors.forename: D I
authors.initials: DI
authors.lastname: Sessler
authors.forename: E I
authors.initials: EI
authors.lastname: Eger
authors.forename: J M
authors.initials: JM
authors.lastname: Sonner
mesh_terms: D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D002245:Carbon Dioxide / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects; D017402:Chlorofluorocarbons / Q000008:administration & dosage / Q000494:pharmacology*; D003080:Cold Temperature; D003503:Cyclobutanes / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology; D016018:Least-Squares Analysis; D016014:Linear Models; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012768:Shivering / Q000187:drug effects
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D017402:Chlorofluorocarbons; D003503:Cyclobutanes; D002245:Carbon Dioxide; C090640:1,2-dichloro-1,2,3,3,4,4-hexafluorocyclobutane; D007530:Isoflurane