Risk assessment of neurotoxic pesticides.
In order to establish safe exposure levels for toxic chemicals, risk assessment guidelines have been developed. A compilation is given by the author on the elements of risk assessment of hazardous neurotoxic pesticides, using data obtained from human epidemiological studies, from animal experiments, from the international literature and from the author's own experiments as well. Well-controlled laboratory studies of neurotoxicity have the potential to provide adequate exposure and effect data for accurate hazard identification. Animal models of neurotoxicity as highly sensitive behavioral and neurophysiological methods as a function of doses, provide data for human low dose extrapolation by using mathematical models. This procedure might be the basis for reducing risk ("risk management"), therefore some examples are given, how to handle properly neurotoxic pesticides with different- high or low-risk.
Lehotzky
K
K
Fodor József Public Health Center, National Institute for Chemical Safety, Budapest, Hungary.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005659:Fungicides, Industrial / Q000633:toxicity; D015386:Hazardous Substances / Q000008:administration & dosage / Q000633:toxicity; D006801:Humans; D007306:Insecticides / Q000633:toxicity; D008954:Models, Biological; D009498:Neurotoxins / Q000008:administration & dosage / Q000633:toxicity*; D009941:Organomercury Compounds / Q000633:toxicity; D009943:Organophosphorus Compounds; D010575:Pesticides / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity; D051381:Rats; D018570:Risk Assessment
D005659:Fungicides, Industrial; D015386:Hazardous Substances; D007306:Insecticides; D009498:Neurotoxins; D009941:Organomercury Compounds; D009943:Organophosphorus Compounds; D010575:Pesticides; D011722:Pyrethrins