title: Preventing lens epithelial cell migration using intraocular lenses with sharp rectangular edges.
abstract: OBJECTIVE
  To compare the preventive effect on posterior capsule opacification (PCO) of an acrylic intraocular lens (IOL) and a silicone IOL, both with sharp rectangular optic edges.
  
  
  METHODS
  Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.
  
  
  METHODS
  After phacoemulsification, an acrylic IOL (AcrySof(R)) was implanted in 1 eye and a silicone IOL (CeeOn 911) in the contralateral eye of 7 rabbits, one of which was omitted from evaluation.
  
  
  RESULTS
  The Miyake-Apple view and histopathological findings 3 weeks after surgery revealed that the lens capsule wrapped tightly around the optic edges, conforming to a distinctly sharp bend, with both IOL types in 5 rabbits. Migrating lens epithelial cells (LECs) were inhibited at the site. The AcrySof IOL had a better capsular bend effect in the histological sections, but there was no apparent difference in PCO development between the 2 IOLs.
  
  
  CONCLUSIONS
  The CeeOn 911 silicone IOL, with sharp rectangular optic edges, showed an effect on preventing PCO that was similar to that of the AcrySof IOL. When a discontinuous capsular bend is created by an IOL with sharp optic edges, the bend may induce contact inhibition of migrating LECs regardless of the lens' material composition.
authors.affiliation: Nishi Eye Hospital, Osaka, Japan. okihiro@nishi-ganka.or.jp
authors.forename: O
authors.initials: O
authors.lastname: Nishi
authors.forename: K
authors.initials: K
authors.lastname: Nishi
authors.forename: K
authors.initials: K
authors.lastname: Wickström
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002448:Cell Adhesion; D002465:Cell Movement; D004847:Epithelial Cells / Q000473:pathology*; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular / Q000295:instrumentation*; D007910:Lenses, Intraocular; D018918:Phacoemulsification / Q000009:adverse effects; D011474:Prosthesis Design; D011817:Rabbits; D012826:Silicone Elastomers; D013499:Surface Properties
chemical_list: D000180:Acrylic Resins; D012826:Silicone Elastomers