title: Biocompatibility correlation of polymeric materials using human osteosarcoma cells.
abstract: Metal implants are the preferred materials to generate articular prostheses, plates, or bone pegs in orthopedic surgery. Although titanium and titanium alloys show a relatively good biocompatibility, clinical experience revealed that coating of the metallic implant surface may increase the biocompatibility. In a search for optimum bone implant surfaces, we determined polarity and contact angle parameters of a variety of polymers and substances and correlated the findings in a biocompatibility assay using an in vitro bone cell model. We report that an optimum adherence of SAOS-2 cells to such surfaces and a good vitality for polymers are characterized by water-based contact angles of 80 degrees and 20 degrees for advancing and receding probes, respectively.
authors.affiliation: Department of Organic Chemistry, Faculty of Chemistry and Pharmacy, University of Tübingen, Germany. keg@kjist.ac.kr
authors.forename: K E
authors.initials: KE
authors.lastname: Geckeler
authors.forename: R
authors.initials: R
authors.lastname: Wacker
authors.forename: W K
authors.initials: WK
authors.lastname: Aicher
mesh_terms: D001672:Biocompatible Materials / Q000494:pharmacology*; D005898:Glass; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D012516:Osteosarcoma; D011076:Polycarboxylate Cement / Q000494:pharmacology; D019904:Polymethyl Methacrylate / Q000494:pharmacology; D011137:Polystyrenes / Q000494:pharmacology; D011143:Polyvinyl Chloride / Q000494:pharmacology; D011145:Polyvinyls / Q000494:pharmacology; D019736:Prostheses and Implants; D014407:Tumor Cells, Cultured
chemical_list: D001672:Biocompatible Materials; D011076:Polycarboxylate Cement; D011137:Polystyrenes; D011145:Polyvinyls; C005506:polycarbonate; C013215:polyvinyl acetate; D011143:Polyvinyl Chloride; D019904:Polymethyl Methacrylate