Solid-phase synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics.
A solid-phase method for the synthesis of 1,2,3, 4-tetrahydro-beta-carboline-containing peptidomimetics has been developed. The key step in the strategy is the Pictet-Spengler condensation of a resin-bound tryptophan-containing fragment with an Fmoc-amino aldehyde.
Li
X
X
Sphinx Pharmaceuticals, A Division of Eli Lilly and Company, Cambridge, Massachusetts 02139, USA.
Zhang
L
L
Zhang
W
W
Hall
S E
SE
Tam
J P
JP
D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D014364:Tryptophan / Q000737:chemistry
D002243:Carbolines; D010455:Peptides; C009804:tryptoline; D014364:Tryptophan