Liver resistance to CCl(4)-induced injury after stimulation of macrophages with various preparations.
Acute toxic hepatitis in male Wistar rats was produced by single injection of 40% CCl(4) (0.2 ml per 100 g body weight in oil). Pretreatment with various immunostimulators (bacterial polysaccharides prodigiozan and salmozan; yeast polysaccharides zymosan, peptidoglycan, and mannan; and hydrolytic enzyme egg lysozyme) produced a hepatoprotective effect correlating which the stimulatory influence on macrophages and increasing in the following order: mannan<peptidoglycan<zymosan<lysozyme<salmozan<prodigiozan.
Kutina
S N
SN
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Zubakhin
A A
AA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008351:Mannans / Q000494:pharmacology; D009113:Muramidase / Q000494:pharmacology; D010457:Peptidoglycan / Q000494:pharmacology; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D011354:Prodigiozan / Q000494:pharmacology; D011458:Prostaglandins E / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D015054:Zymosan / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D008351:Mannans; D010457:Peptidoglycan; D011135:Polysaccharides, Bacterial; D011458:Prostaglandins E; C029023:salmozan; D015054:Zymosan; D011354:Prodigiozan; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase; D009113:Muramidase