title: Production kinetics of acidophilin 801, a bacteriocin produced by Lactobacillus acidophilus IBB 801.
abstract: Lactobacillus acidophilus IBB 801 produces a small bacteriocin, designated acidophilin 801. Studying the relationship between growth and bacteriocin biosynthesis revealed primary metabolite kinetics of bacteriocin production with a peak activity at the end of the exponential growth phase followed by a decrease during the stationary phase. Both microbial growth and bacteriocin production was inhibited by lactic acid. Whereas volumetric bacteriocin production (activity units (AU) ml(-1)) was favoured under pH-controlled conditions, bacteriocin titres rapidly decreased because of strong adsorption of the bacteriocin molecules to the producing cells under less acidic conditions.
authors.affiliation: Genetic Engineering Laboratory, Institute of Biology, Bucharest, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Zamfir
authors.forename: R
authors.initials: R
authors.lastname: Callewaert
authors.forename: P C
authors.initials: PC
authors.lastname: Cornea
authors.forename: L
authors.initials: L
authors.lastname: De Vuyst
mesh_terms: D001430:Bacteriocins / Q000096:biosynthesis*; D003470:Culture Media; D007700:Kinetics; D007779:Lactobacillus acidophilus / Q000254:growth & development* / Q000378:metabolism*
chemical_list: D001430:Bacteriocins; D003470:Culture Media; C405711:acidophilin 801