title: Role of Drosophila IKK gamma in a toll-independent antibacterial immune response.
abstract: We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF-dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKK gamma-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila.
authors.affiliation: Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15, rue R. Descartes, F67084 Strasbourg, France.
authors.forename: S
authors.initials: S
authors.lastname: Rutschmann
authors.forename: A C
authors.initials: AC
authors.lastname: Jung
authors.forename: R
authors.initials: R
authors.lastname: Zhou
authors.forename: N
authors.initials: N
authors.lastname: Silverman
authors.forename: J A
authors.initials: JA
authors.lastname: Hoffmann
authors.forename: D
authors.initials: D
authors.lastname: Ferrandon
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D004330:Drosophila / Q000276:immunology*; D029721:Drosophila Proteins; D005786:Gene Expression Regulation / Q000276:immunology; D051550:I-kappa B Kinase; D007113:Immunity, Innate; D019476:Insect Proteins / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D017346:Protein Serine-Threonine Kinases / Q000276:immunology*; D011956:Receptors, Cell Surface; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors; D014157:Transcription Factors / Q000235:genetics / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D029721:Drosophila Proteins; D019476:Insect Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C101626:Rel protein, Drosophila; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; D014157:Transcription Factors; D017346:Protein Serine-Threonine Kinases; D051550:I-kappa B Kinase; C496563:IKKbeta protein, Drosophila