title: The course of radiologic damage during the first six years of rheumatoid arthritis.
abstract: OBJECTIVE
  To describe the radiologic course in a large cohort of patients with early rheumatoid arthritis (RA) and to analyze individual components of damage.
  
  
  METHODS
  Five hundred two patients with recent-onset RA (disease duration <1 year) underwent annual radiologic assessment for a maximum of 6 years in this longitudinal prospective study. The study was designed to investigate the efficacy of 3 different therapeutic strategies. For the assessment of radiologic damage, radiographs of the hands and feet were scored according to the modified Sharp/van der Heijde method (SHS; range 0-448). A mean of 2.9 (range 1-7) radiographs was read per patient.
  
  
  RESULTS
  Stable rates of progression of the SHS, erosion score, and narrowing score were found over the course of RA: the mean rates were 8.6, 5.4, and 3.2 modified Sharp units per year, respectively. The rate of progression of newly (not previously) damaged joints declined, and the rate of progression of already damaged joints (which became more damaged) increased during followup, leading to an equal contribution to progression of the SHS at 5 years. The joints of the feet, especially the fifth metatarsophalangeal joint, generally became eroded earlier and more of them became eroded compared with the joints of the hands.
  
  
  CONCLUSIONS
  Radiologic damage progresses at a constant rate. In advanced disease, monitoring the progression of previously existing damage is as important as assessing new abnormalities in previously undamaged joints. Radiographs of the feet should be included in assessments of radiologic damage that are used in clinical intervention trials and daily practice.
authors.affiliation: Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands.
authors.forename: H M
authors.initials: HM
authors.lastname: Hulsmans
authors.forename: J W
authors.initials: JW
authors.lastname: Jacobs
authors.forename: D M
authors.initials: DM
authors.lastname: van der Heijde
authors.forename: G A
authors.initials: GA
authors.lastname: van Albada-Kuipers
authors.forename: Y
authors.initials: Y
authors.lastname: Schenk
authors.forename: J W
authors.initials: JW
authors.lastname: Bijlsma
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001175:Arthrography / Q000009:adverse effects; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology*; D013997:Time Factors; D014033:Toe Joint / Q000000981:diagnostic imaging
chemical_list: D018501:Antirheumatic Agents