title: Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides.
abstract: The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.
authors.affiliation: Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA.
authors.forename: A
authors.initials: A
authors.lastname: Nefzi
authors.forename: M A
authors.initials: MA
authors.lastname: Giulianotti
authors.forename: N A
authors.initials: NA
authors.lastname: Ong
authors.forename: R A
authors.initials: RA
authors.lastname: Houghten
mesh_terms: D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*
chemical_list: D007093:Imidazoles; D009842:Oligopeptides