[The survival of mice and the metallothionein content of their livers and kidneys as criteria for assessing exposure to pulsed neutron radiation].
The effect of pulsed neutron radiation was studied in comparison with continuous neutron radiation and continuous gamma-radiation. Animal survival and induction of metallothionein (MT) synthesis in liver and kidney of mice exposed to equivalent doses were chosen as criteria for evaluation of radiation effects. It was found that the level of MT in liver and kidney of mice exposed to neutron radiation decreased 24 hours after irradiation and then continued decreasing in kidney for 48 hours after irradiation. This is evidence of more intensive free-radical processes initiated by pulsed neutron radiation. At the same time, RBE values of pulsed neutrons did not differ significantly from that of continuous neutron radiation.
Ul'ianenko
S E
SE
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, Russia. ustev@kaluga.ru
Rott
G M
GM
Kuznetsova
M N
MN
Smoryzanova
O A
OA
D000818:Animals; D002106:Cadmium Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons; D005260:Female; D015902:Gamma Cameras; D005720:Gamma Rays; D007668:Kidney / Q000737:chemistry / Q000000981:diagnostic imaging*; D008099:Liver / Q000737:chemistry / Q000528:radiation effects*; D008297:Male; D008668:Metallothionein / Q000032:analysis / Q000528:radiation effects*; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000401:mortality*; D011859:Radiography; D013997:Time Factors
D002106:Cadmium Radioisotopes; D008668:Metallothionein