[Production of pharmaceutical proteins with mammary gland bioreactor].
Mammary gland bioreactor is a useful biological system which expresses foreign genes in the mammary gland and produces functional pharmaceutical proteins in milk. This production route is appealing for it's advantages, such as the simplicity of access to the expressed protein, the high production of the mammary gland, the capabilities to perform translational modifications. As an alternative of cell culture systems, it is a new biotechnology. The article reviews some aspects on generation and characterization of mammary gland bioreactor, separation and purification of foreign protein from milk and some questions that need to be answered on the route.
Liu
S
S
National Laboratory of Molecular Virology and Genetic Engineering, Institute of Virology, Beijing.
Liang
G D
GD
D000818:Animals; D030801:Animals, Genetically Modified; D019149:Bioreactors; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008894:Milk Proteins / Q000096:biosynthesis* / Q000302:isolation & purification; D011994:Recombinant Proteins / Q000096:biosynthesis*
D008894:Milk Proteins; D011994:Recombinant Proteins