The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection.
To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected individuals (controls). H. pylori infection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; chi(2) = 13; P = 0.00032; P value corrected for multiple comparisons [Bonferroni correction] = 0. 00063).
Kunstmann
E
E
Department of Molecular Human Genetics, Ruhr-University, 44780 Bochum, Germany. Erdmute.M.Kunstmann@rurh-uni-bochum.de
Hardt
C
C
Elitok
E
E
Harder
M
M
Suerbaum
S
S
Peitz
U
U
Schmiegel
W
W
Epplen
J T
JT
D000483:Alleles; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000209:etiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
D016693:Receptors, Antigen, T-Cell, alpha-beta