An introduction to the changes in gene expression that occur after cerebral ischaemia.
Ischaemia is the final common pathway of brain cell death following a variety of insults. We consider the effect of cerebral ischaemia on gene expression, concentrating on immediate early genes, those encoding heat shock proteins, growth factors, cytokines, adhesion molecules, nitric oxide synthase and proteins involved in programmed cell death. We conclude that the changes in gene expression resulting from ischaemia are important determinants of neuronal and glial survival. In the future it may become possible to manipulate gene expression to limit the extent of damage arising from cerebral ischaemia.
Papadopoulos
M C
MC
Department of Neurosurgery, Atkinson Morley's Hospital, St George's Medical School, University of London, UK. MPapadopoulos@compuserve.com
Giffard
R G
RG
Bell
B A
BA
D002545:Brain Ischemia / Q000235:genetics* / Q000378:metabolism; D016923:Cell Death / Q000235:genetics; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D006133:Growth Substances / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D019001:Nitric Oxide Synthase / Q000378:metabolism
D006133:Growth Substances; D006360:Heat-Shock Proteins; D019001:Nitric Oxide Synthase