Cytotoxicity and antibacterial activity of ethanol extract from leaves of a herbal drug, boneset (Eupatorium perfoliatum).
The cytotoxic and antibacterial activity of an ethanol extract of leaves of a herbal drug, boneset (Eupatorium perfoliatum), was investigated. The extract showed potent cytotoxicity with EC(50) values (12-14 microg/mL) comparable to a standard cytotoxic agent, chlorambucil. The extract showed a weak antibacterial activity against gram-positive test organisms (Staphylococcus aureus and Bacillus megaterium).
Habtemariam
S
S
School of Chemical and Life Sciences, University of Greenwich, London, UK. s.habtemariam@gre.ac.uk
Macpherson
A M
AM
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019659:Asteraceae; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D000900:Anti-Bacterial Agents; D010936:Plant Extracts