31P magnetic resonance spectroscopy in fibromyalgic muscle.
OBJECTIVE
To measure inorganic phosphate (Pi), phosphocreatine (PCr), ATP and phosphodiesters (PDE) in fibromyalgic muscle tissue by (31)P magnetic resonance spectroscopy.


METHODS
A 1.5 Tesla scanner with a P 100 surface coil was used to examine 15 patients (mean age 49.9+/-14.3 yr) with fibromyalgia, according to the American College of Rheumatology criteria, and 17 healthy controls (mean age 30.2+/-5.8 yr).


RESULTS
Compared with the controls, there were increases in the levels of PDE (+22%, P = 0.032) and Pi (+19%, P = 0.019) in the spectra of fibromyalgia patients, but there was no difference in pH.


CONCLUSIONS
The metabolic differences we found may have been related to weakness and fatigue in the fibromyalgia patients, but they do not fully explain the fibromyalgia symptoms.
Sprott
H
H
Department of Rheumatology and Institute of Physical Medicine, University Hospital Zürich, Switzerland.
Rzanny
R
R
Reichenbach
J R
JR
Kaiser
W A
WA
Hein
G
G
Stein
G
G
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D004983:Ethanolamines / Q000378:metabolism; D005260:Female; D005356:Fibromyalgia / Q000378:metabolism*; D005997:Glycerylphosphorylcholine / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D009705:Nucleosides / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus; D010767:Phosphorylcholine / Q000378:metabolism; D012016:Reference Values
D004983:Ethanolamines; D009705:Nucleosides; D010710:Phosphates; D010714:Phosphatidylethanolamines; D010725:Phosphocreatine; D010767:Phosphorylcholine; C002449:glycerophosphoethanolamine; D010758:Phosphorus; D005997:Glycerylphosphorylcholine; C005448:phosphorylethanolamine; D000255:Adenosine Triphosphate