title: A practical synthesis of the ABC ring model of ecteinascidins.
abstract: A practical synthesis of 1,2,3,4,5,6-hexahydro-1,5-imino-10-hydroxy-9-methoxy-3,8,11-trimethyl-3- benzazocin-4-one (3) as an ABC ring model compound of ecteinascidin 743 and safracins from 3-hydroxy-4-methoxy-5-methylbenzaldehyde (7) is described. The overall yield in 15 steps is 27%.
authors.affiliation: Meiji Pharmaceutical University, Tokyo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Tachi
authors.forename: R
authors.initials: R
authors.lastname: Seki
authors.forename: H
authors.initials: H
authors.lastname: Kamayachi
authors.forename: A
authors.initials: A
authors.lastname: Kubo
mesh_terms: D004149:Dioxoles / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013057:Spectrum Analysis; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin
chemical_list: D004149:Dioxoles; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin