Influence of opioid receptor antagonists on motor-impairing effects of benzodiazepines.
The influence of naloxone and naltrexone on the motor-impairing effects of diazepam, chlordiazepoxide, clonazepam and estazolam were studied in the aerial righting reflex test (mice, rats), and the first two drugs were examined in the rota-rod test (mice). Benzodiazepine-induced motor incoordination was significantly decreased by naloxone and naltrexone (4-16 mg/kg) in mice and rats in aerial righting reflex test. The motor-impairing effects of diazepam and chlordiazepoxide observed in rota-rod test were significantly diminished only by naltrexone (8-16 mg/kg). These data seem to confirm some interactions between benzodiazepines and opioid system.
Fidecka
S
S
Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
Langwiński
R
R
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001259:Ataxia / Q000139:chemically induced*; D001569:Benzodiazepines; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology*; D009292:Narcotic Antagonists; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D009292:Narcotic Antagonists; D001569:Benzodiazepines; D009270:Naloxone; D009271:Naltrexone