Synthesis of NG-061 and its analogs, and their biological evaluation as an enhancer of nerve growth factor.
A novel potentiator of nerve growth factor (NGF), NG-061, which had been isolated from the fermentation broth of Penicillium minioluteum F-4627, was synthesized from methoxybenzoquinone and phenylacetylhydrazine in a single step. A series of acyl hydrazone derivatives were also synthesized and their potentiator activity of neurotrophic effect of NGF on neurite outgrowth was evaluated by assay with a rat pheochromocytoma cell line PC12.
Eguchi
T
T
Department of Chemistry and Materials Science, Tokyo Institute of Technology, Japan.
Kanai
S
S
Kakinuma
K
K
Okazaki
T
T
Mizoue
K
K
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000819:agonists*; D016716:PC12 Cells; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013057:Spectrum Analysis
D006834:Hydrazines; C119398:NG 061; D010648:Phenylacetates; D020932:Nerve Growth Factor