Lack of effect of repeated treatment with a glycineB receptor partial agonist on the amphetamine-induced hyperactivity in rats.
The effect of acute and repeated (once daily, 14 days) administration of a potential antidepressant, the glycineB partial agonist 1-aminocyclopropanecarboxylic acid (ACPC, 100-400 mg/kg, ip), on the hyperactivity induced by amphetamine (0.5 mg/kg, sc) in rats was studied. Neither acute nor repeated treatment with the drug affected the hyperlocomotion induced by amphetamine. The obtained results indicate that ACPC does not resemble antidepressant drugs in this behavioral model.
Wesołowska
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Borycz
J
J
Chojnacka-Wójcik
E
E
Przegaliński
E
E
D000598:Amino Acids, Cyclic / Q000494:pharmacology*; D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006948:Hyperkinesis / Q000139:chemically induced*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018009:Receptors, Glycine / Q000819:agonists; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
D000598:Amino Acids, Cyclic; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; C023863:1-aminocyclopropane-1-carboxylic acid; D000661:Amphetamine