What is the effect of combining artesunate and praziquantel in the treatment of Schistosoma mansoni infections?
A group of 110 individuals with Schistosoma mansoni infection was investigated. Patients were allocated to one of three treatment groups and given artesunate or praziquantel alone or both in combination. Combined artesunate-praziquantel significantly increased the number of individuals cured at 5 weeks post-treatment, but at 12 weeks was only better than artesunate alone and at 24 weeks there was no statistically significant difference between the three groups. Egg count reduction rate was similar to the rate obtained with praziquantel used alone.
De Clercq
D
D
Région Médicale de Saint Louis, Programme Espoir, Saint Louis, Senegal.
Vercruysse
J
J
Verlé
P
P
Kongs
A
A
Diop
M
M
D000293:Adolescent; D000328:Adult; D000818:Animals; D037621:Artemisinins; D000077332:Artesunate; D002648:Child; D002675:Child, Preschool; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011223:Praziquantel / Q000008:administration & dosage*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D012556:Schistosomicides / Q000008:administration & dosage*; D012675:Senegal; D012717:Sesquiterpenes / Q000008:administration & dosage*
D037621:Artemisinins; D012556:Schistosomicides; D012717:Sesquiterpenes; D000077332:Artesunate; D011223:Praziquantel