Pentobarbital-induced modulation of flexor and H-reflexes in spinal rats.
Electrophysiological recordings of the H-reflex and nonnociceptive flexion reflex were obtained from pentobarbital-anesthetized Intact rats and from both, anesthetized and unanesthetized groups of Acute and Chronic Spinal rats. Results showed that the flexor, but not H-reflex, of Chronic Spinal rats was significantly larger than that of all other groups, which did not differ among themselves. The antispastic drug baclofen dose-dependently decreased the flexion response of Chronic Spinal rats (A(50)=4.3 mg/kg+/-2.1 and 9.0 mg/kg).
Duke
M
M
Department of Psychology 236 Audubon Hall Louisiana State University, 70803, Baton Rouge, LA, USA.
Advokat
C
C
D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D004558:Electric Stimulation; D006181:H-Reflex / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D013119:Spinal Cord Injuries / Q000503:physiopathology*
D000759:Adjuvants, Anesthesia; D009125:Muscle Relaxants, Central; D001418:Baclofen; D010424:Pentobarbital