Liver preservation: a comparison of celsior to colloid-free University of Wisconsin solution.
BACKGROUND
Celsior (CEL) was formulated specifically for heart preservation. Recently some preliminary reports have suggested that CEL is also effective for liver preservation. In this study liver preservation with CEL was compared to colloid-free University of Wisconsin solution (MUW).


METHODS
Arterialized rat liver isografts were flushed and stored for 24 hr at 0 degrees C in CEL or MUW before orthotopic transplantation. Plasma albumin, bilirubin, glucose, aspartate aminotransferase, and alkaline phosphatase were measured 1, 2, 3, 7, 14, 21, and 28 days after surgery.


RESULTS
All recipients of MUW-preserved livers survived, none of the recipients of CEL-preserved grafts lived beyond 3 days. On day 1, AST was raised in all rats but rats receiving CEL-preserved liver grafts were also markedly hypoglycemic, hypoalbuminemic and had elevated alkaline phosphatase.


CONCLUSIONS
Celsior is not an effective solution for long-term liver preservation in its present composition.
Howden
B O
BO
Monash University, Department of Surgery, Monash Medical Centre, Melbourne, Australia.
Jablonski
P
P
D000241:Adenosine / Q000494:pharmacology; D000469:Alkaline Phosphatase / Q000097:blood; D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004187:Disaccharides / Q000494:pharmacology; D004573:Electrolytes / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D006639:Histidine / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008099:Liver; D016031:Liver Transplantation / Q000502:physiology; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009926:Organ Preservation / Q000379:methods; D019188:Organ Preservation Solutions / Q000494:pharmacology; D011887:Raffinose / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014185:Transplantation, Isogeneic
C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose