title: Myocardial fixation of anticardiac troponin I antibody and cardiac troponin I release.
abstract: BACKGROUND
  The threefold aim of this experimental study was to test the correlation of cardiac troponin I released to myocardial infarction size and myocardial fixation of anticardiac troponin I antibody and to determine how long after myocardial infarction the measure of cardiac troponin I concentration can evaluate myocardial infarction size.
  
  
  METHODS
  Forty rabbits were assigned either to a control group or to an experimental preconditioned group. Infarction was obtained by tightening a snare around the left anterior descending artery. Serial venous blood samples were drawn for measurement of cardiac troponin I. The rabbits were sacrificed at 72 hours and a histological study was performed to determine the infarct size and the size of the area void of fixation of anticardiac troponin I antibody.
  
  
  RESULTS
  There was a linear correlation between the total amount of CTn I released and both infarct size (r=0.45, p<0.02) and the size of the area void of anti-cardiac troponin I antibody (r=0.47, p<0.02). These two sizes were strongly correlated (r=0.95, p<0.02). The hour 9 CTn I sample was the best correlated with both the infarct size (r=0.47, p<0.02) and the size of area void of anticardiac troponin I antibody (r=0.45, p<0.02).
  
  
  CONCLUSIONS
  Our study shows that: 1) cardiac troponin I release is correlated to both myocardial infarction size and the size of area void of fixation of anticardiac troponin I antibody, 2) the area void of anticardiac troponin I antibody fixation includes the whole ischemic area, and 3) evaluation of myocardial infarction size can be obtained by CTn I concentration as early as the ninth hour.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Saint-Jacques Hospital, Besançon, France.
authors.forename: K
authors.initials: K
authors.lastname: Alwan
authors.forename: S
authors.initials: S
authors.lastname: Chocron
authors.forename: J L
authors.initials: JL
authors.lastname: Mourand
authors.forename: G
authors.initials: G
authors.lastname: Toubin
authors.forename: P
authors.initials: P
authors.lastname: Gauchez
authors.forename: B
authors.initials: B
authors.lastname: Kantelip
authors.forename: J P
authors.initials: JP
authors.lastname: Kantelip
authors.forename: J P
authors.initials: JP
authors.lastname: Etievent
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis*; D007150:Immunohistochemistry; D019157:Ischemic Preconditioning, Myocardial; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000737:chemistry*; D011817:Rabbits; D013997:Time Factors; D019210:Troponin I / Q000032:analysis / Q000276:immunology / Q000378:metabolism*
chemical_list: D000906:Antibodies; D019210:Troponin I