title: Pharmacokinetics of a parenteral carbapenem, biapenem, in patients with end-stage renal disease and influence of haemodialysis.
abstract: The effects of haemodialysis on the pharmacokinetics of a carbapenem, biapenem, were evaluated in five patients with end-stage renal disease, who received 1 h iv infusions of 300 mg biapenem on both the days on and off 4 h haemodialysis. With haemodialysis, plasma biapenem exhibited two elimination phases, one during and the other after haemodialysis with half-lives of 1.16 +/- 0.12 and 3.33 +/- 0. 91 h, respectively. Ninety percent of biapenem was removed from blood to dialysate. Without haemodialysis, plasma biapenem was mono-exponentially eliminated with a half-life of 4.35 +/- 1.30 h.
authors.affiliation: Department of Pharmacology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nagashima
authors.forename: O
authors.initials: O
authors.lastname: Kozawa
authors.forename: T
authors.initials: T
authors.lastname: Otsuka
authors.forename: K
authors.initials: K
authors.lastname: Kohno
authors.forename: M
authors.initials: M
authors.lastname: Minamoto
authors.forename: M
authors.initials: M
authors.lastname: Yokokawa
authors.forename: M
authors.initials: M
authors.lastname: Kanamaru
authors.forename: T
authors.initials: T
authors.lastname: Uematsu
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000097:blood* / Q000493:pharmacokinetics; D019540:Area Under Curve; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D013845:Thienamycins / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D000890:Anti-Infective Agents; D013845:Thienamycins; C065257:biapenem