title: Heterogeneity of AmpC cephalosporinases of Hafnia alvei clinical isolates expressing inducible or constitutive ceftazidime resistance phenotypes.
abstract: Ten unrelated Hafnia alvei clinical isolates were grouped according to either their low-level and inducible cephalosporinase production or their high-level and constitutive cephalosporinase production phenotype. Their AmpC sequences shared 85 to 100% amino acid identity. The immediate genetic environment of ampC genes was conserved in H. alvei isolates but was different from that found in other ampC-possessing enterobacterial species.
authors.affiliation: Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France.
authors.forename: D
authors.initials: D
authors.lastname: Girlich
authors.forename: T
authors.initials: T
authors.lastname: Naas
authors.forename: S
authors.initials: S
authors.lastname: Bellais
authors.forename: L
authors.initials: L
authors.lastname: Poirel
authors.forename: A
authors.initials: A
authors.lastname: Karim
authors.forename: P
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000595:Amino Acid Sequence; D002442:Ceftazidime / Q000494:pharmacology*; D002510:Cephalosporinase / Q000235:genetics* / Q000378:metabolism; D004352:Drug Resistance, Microbial; D016521:Electrophoresis, Gel, Pulsed-Field; D005280:Fenoterol; D005798:Genes, Bacterial; D014644:Genetic Variation; D020611:Hafnia alvei / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D005280:Fenoterol; D002442:Ceftazidime; D002510:Cephalosporinase; D001618:beta-Lactamases