Comparison of intubating conditions following propofol and succinylcholine with propofol and remifentanil 2 micrograms kg-1 or 4 micrograms kg-1.
We evaluated the intubating conditions, haemodynamic responses and duration of apnoea in 60 healthy adult patients after propofol 2 mg kg-1 combined with either a bolus of remifentanil 2 micrograms kg-1 or 4 micrograms kg-1, or succinylcholine 1 mg kg-1. Patients intubated following remifentanil showed dose-dependent intubating conditions, similar at 4 micrograms kg-1 to the conditions produced with succinylcholine. Post-induction mean arterial pressure decreased from baseline values by 21% (P < 0.0001), 28% (P < 0.0001) and 8% (P > 0.05) in the remifentanil 2 micrograms kg-1, remifentanil 4 micrograms kg-1 and succinylcholine 1 mg kg-1 groups, respectively. The mean (SD) duration of apnoea following induction was 9.3 (2.6) min and 12.8 (2.9) min in the remifentanil 2 micrograms kg-1 and 4 micrograms kg-1 groups, and 6.0 (0.9) min in the succinylcholine group (P < 0.001 between groups).
McNeil
I A
IA
Department of Anaesthesia, Hull Royal Infirmary, UK.
Culbert
B
B
Russell
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage; D018686:Anesthetics, Intravenous; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D008875:Middle Aged; D009467:Neuromuscular Depolarizing Agents; D010880:Piperidines / Q000008:administration & dosage; D015742:Propofol; D000077208:Remifentanil; D016037:Single-Blind Method; D013390:Succinylcholine
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D009467:Neuromuscular Depolarizing Agents; D010880:Piperidines; D013390:Succinylcholine; D000077208:Remifentanil; D015742:Propofol