Structure-based design of novel bicyclic nonpeptide inhibitors for the src SH2 domain.
Shakespeare
W C
WC
ARIAD Pharmaceuticals, Inc., 26 Landsdowne Street, Cambridge, Massachusetts 02139-4234, USA. william.shakespeare@ariad.com
Bohacek
R S
RS
Azimioara
M D
MD
Macek
K J
KJ
Luke
G P
GP
Dalgarno
D C
DC
Hatada
M H
MH
Lu
X
X
Violette
S M
SM
Bartlett
C
C
Sawyer
T K
TK
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D015195:Drug Design; D005454:Fluorescence Polarization; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D018909:src Homology Domains
D001643:Bridged Bicyclo Compounds