The effects of antipsychotic medication on saccadic eye movement abnormalities in Huntington's disease.
1. The study was a prospective open trial done to determine the effect of antipsychotic medication on saccadic eye movements in patients with Huntington's disease (HD). The authors tested 16 outpatients with HD, 8 of whom were drug free and 8 of whom were on antipsychotic medication. We also tested 24 healthy control subjects. 2. The antisaccade task was used to investigate the voluntary control of saccadic eye movements. Antisaccade latencies and error rates were used as outcome measures. Both HD patient groups showed significantly more antisaccade abnormalities than controls and the rate of abnormalities was very similar between the drug-free and medicated patient groups. 3. The results suggest that these abnormalities are related to underlying neuropathology rather than effects of medication. Either specific dysfunction of the dorsolateral prefrontal cortex or of the subcortical circuit connecting this cortical area to the superior colliculus via the striatum are likely to be responsible for the generation of such antisaccade eye movement abnormalities.
Dursun
S M
SM
Department of Psychiatry, Faculty of Medicine, University of Leicester, UK. sdursun@is.dal.ca
Burke
J G
JG
Andrews
H
H
Mlynik-Szmid
A
A
Reveley
M A
MA
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012438:Saccades / Q000187:drug effects* / Q000502:physiology
D014150:Antipsychotic Agents