Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special?
Alterations in dopamine neurotransmission have been hypothesized to play a role in the etiology of schizophrenia. We considered the dopamine D3 receptor gene on chromosome 3 as a candidate gene for an association analysis. We compared PCR-based genotype markers for healthy controls (n=120) and patients (n=95) with schizophrenia and schizophrenia spectrum disorders as diagnosed by consensus according to DSM-III-R. Our results possibly indicate an association of schizoaffective disorder with DRD3 homozygosity (P=0.056).
Meszaros
K
K
University Hospital for Psychiatry, Department of General Psychiatry, Währinger Gürtel 18-20, A-1090, Vienna, Austria.
Lenzinger
E
E
Hornik
K
K
Füreder
T
T
Stompe
T
T
Willinger
U
U
Heiden
A
A
Fathi
N
N
Gerhard
E
E
Fuchs
K
K
Sieghart
W
W
Kasper
S
S
Aschauer
H N
HN
D000328:Adult; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006720:Homozygote; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3