The Na+/K(+)-pump protects muscle excitability and contractility during exercise.
In skeletal muscle, the concentration of Na+/K(+)-pumps is high and increases through training. In isolated muscles, contractile endurance depends in part on Na+/K(+)-pump concentration. Exercise leads to rundown of Na+/K(+)-gradients, compound action potentials, and force. Early and efficient activation of the Na+/K(+)-pump, however, protects excitability and contractility.
Nielsen
O B
OB
Department of Physiology, University of Aarhus, Denmark. obn@fi.au.dk
Clausen
T
T
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004285:Dogs; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D009119:Muscle Contraction / Q000502:physiology*; D018763:Muscle Fatigue / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology*; D010806:Physical Education and Training; D010807:Physical Endurance; D011188:Potassium / Q000097:blood / Q000502:physiology; D011898:Ranidae; D051381:Rats; D012964:Sodium / Q000097:blood / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium