[Changes of erythrocyte and platelet membrane lipid pattern in different subtypes of dementia].
OBJECTIVE
To investigate the changes of platelet and erythrocyte membrane lipids and phospholipid composition in different types of dementia.


METHODS
There were 19 patients with Alzheimer's disease, 25 patients with Binswanger's disease, 23 patients with multi-infarct dementia, 11 patients with single cortical infarct dementia, 7 patients with vascular dementia of haemodynamic type, 18 patients with dementia following Parkinson's disease, and 25 senile controls. Platelet and erythrocyte membrane cholesterol, total phospholipids and individual phospholipids were quantified.


RESULTS
When compared with senile controls, the decrease of total phospholipids, phosphatidylcholine and phosphatidylethanolamine and the increase of cholesterol and cholesterol/total phospholipids ratio on the erythrocyte and platelet membrane were found in patients with Binswanger's disease and in those with multi-infarct dementia. The increase of erythrocyte and platelet membrane cholesterol, cholesterol/phospholipids ratio was found, but there was no significant change in membrane total phospholipids and phospholipid composition in patients with single cortical infarct dementia.


CONCLUSIONS
Metabolic disorders of platelet and erythrocyte membrane phospholipids were noted in patients with Binswanger's disease. These disorders were related to white matter low attenuation.
Chen
C
C
Department of Neurology, Jinan Military General Hospital.
Jia
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H
Ma
H
H
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism; D015161:Dementia, Multi-Infarct / Q000097:blood*; D015140:Dementia, Vascular / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*
D008563:Membrane Lipids; D010743:Phospholipids