Scavenging of reactive oxygen species leads to diminished peritoneal tumor recurrence.
Previously, we demonstrated that RBCs inhibit the recurrence of perioperatively spilled tumor cells. The aim of this study was to identify on which RBC component(s) the inhibitory effect is based. By using a cell-seeding model in rats, the effect of RBC-related antioxidant scavengers [hemoglobin, catalase, and superoxide dismutase (SOD)] on peritoneal tumor recurrence was investigated. i.p. injection of hemoglobin caused 45% more tumor load (P < 0.0001). At least 40% inhibition of tumor recurrence was achieved with the use of catalase or SOD (P < 0.05). Combining SOD and catalase did not lead to additional inhibition of tumor recurrence. Inhibition of the overwhelming oxidative potential after surgical peritoneal trauma with the use of scavengers may lead to interesting new approaches for diminishing peritoneal tumor recurrence.
van Rossen
M E
ME
Laboratory for Experimental Surgery and Oncology, Erasmus University Rotterdam, The Netherlands.
Sluiter
W
W
Bonthuis
F
F
Jeekel
H
H
Marquet
R L
RL
van Eijck
C H
CH
D000230:Adenocarcinoma / Q000517:prevention & control; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002374:Catalase / Q000097:blood / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000517:prevention & control; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D016166:Free Radical Scavengers / Q000097:blood / Q000494:pharmacology*; D006454:Hemoglobins / Q000494:pharmacology*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009366:Neoplasm Seeding; D009368:Neoplasm Transplantation; D010534:Peritoneal Neoplasms / Q000517:prevention & control*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000975:Antioxidants; D016166:Free Radical Scavengers; D006454:Hemoglobins; D017382:Reactive Oxygen Species; D002374:Catalase; D013482:Superoxide Dismutase