title: Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands.
abstract: Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs).
authors.affiliation: Department of Chemistry, Emory University, Atlanta, GA 30322, USA. dmohler@emory.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Mohler
authors.forename: G
authors.initials: G
authors.lastname: Shen
authors.forename: A K
authors.initials: AK
authors.lastname: Dotse
mesh_terms: D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008024:Ligands; D009687:Nuclear Proteins / Q000378:metabolism; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004151:Dipeptides; D007202:Indicators and Reagents; D008024:Ligands; D009687:Nuclear Proteins; D019151:Peptide Library; D010455:Peptides; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D014157:Transcription Factors