title: Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.
abstract: Using quantitative PET, the authors studied the binding of [11C]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [11C]PK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in [11C]PK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.
authors.affiliation: INSERM U334, Service Hospitalier Frédéric Joliot, Orsay, France. pappata@shfj.cea.fr
authors.forename: S
authors.initials: S
authors.lastname: Pappata
authors.forename: M
authors.initials: M
authors.lastname: Levasseur
authors.forename: R N
authors.initials: RN
authors.lastname: Gunn
authors.forename: R
authors.initials: R
authors.lastname: Myers
authors.forename: C
authors.initials: C
authors.lastname: Crouzel
authors.forename: A
authors.initials: A
authors.lastname: Syrota
authors.forename: T
authors.initials: T
authors.lastname: Jones
authors.forename: G W
authors.initials: GW
authors.lastname: Kreutzberg
authors.forename: R B
authors.initials: RB
authors.lastname: Banati
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000473:pathology*; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D007546:Isoquinolines; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging* / Q000473:pathology*; D013787:Thalamic Nuclei / Q000000981:diagnostic imaging* / Q000473:pathology*; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D007546:Isoquinolines; C037850:PK 11195