title: Plasma cortisol levels in elderly female subjects with Alzheimer's disease: a cross-sectional and longitudinal study.
abstract: We investigated the plasma cortisol levels at a fasting state in elderly female Alzheimer's disease (AD), vascular dementia (VD), and non-demented subjects (n=66, 28 and 21, respectively). Twenty-eight AD subjects were followed for 40 months. The plasma cortisol levels in AD and VD subjects were significantly higher than those of non-demented subjects at baseline. In AD subjects in relatively early stages of the disease [Mini-Mental State Examination (MMSE)], at baseline, high plasma cortisol led to rapid declines in MMSE scores over a 40-month period.
authors.affiliation: Department of Geriatrics, Nagoya University, Graduate School of Medicine, 65 Tsuruma-Cho, Showa-Ku, Nagoya, 466-8550, Aichi, Japan. umegaki@tsuru.med.nagoya-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Umegaki
authors.forename: H
authors.initials: H
authors.lastname: Ikari
authors.forename: H
authors.initials: H
authors.lastname: Nakahata
authors.forename: H
authors.initials: H
authors.lastname: Endo
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: O
authors.initials: O
authors.lastname: Ogawa
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: A
authors.initials: A
authors.lastname: Iguchi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000523:psychology; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D015140:Dementia, Vascular / Q000097:blood* / Q000523:psychology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008137:Longitudinal Studies; D008609:Mental Status Schedule / Q000706:statistics & numerical data*; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; D006854:Hydrocortisone