title: Sonoclot coagulation analysis of in-vitro haemodilution with resuscitation solutions.
abstract: The colloid and crystalloid solutions used for resuscitation should preferably be free from effects on coagulation. In 10 volunteers, the effects of haemodilution with various concentrations of 0.9% sodium chloride and 4% succinylated gelatin were assessed by Sonoclot analysis, which describes the whole coagulation process. Small and moderate haemodilution (up to 40%) with 0.9% sodium chloride promoted coagulation. Similar haemodilution with 4% succinylated gelatin impaired coagulation, and at 60% haemodilution coagulation was very poor. These findings need to be confirmed in vivo and their clinical relevance determined.
authors.affiliation: Accident and Emergency Department, Royal London Hospital, Whitechapel, UK.
authors.forename: E V
authors.initials: EV
authors.lastname: Brazil
authors.forename: T J
authors.initials: TJ
authors.lastname: Coats
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005780:Gelatin / Q000494:pharmacology; D006438:Hemodilution; D006801:Humans; D066298:In Vitro Techniques; D010952:Plasma Substitutes / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology; D013386:Succinates / Q000494:pharmacology
chemical_list: D010952:Plasma Substitutes; D013386:Succinates; C060085:succinylated gelatin; D012965:Sodium Chloride; D005780:Gelatin