title: Comparative activities of polycationic peptides and clinically used antimicrobial agents against multidrug-resistant nosocomial isolates of Acinetobacter baumannii.
abstract: The in vitro activity of buforin II, cecropin P1, indolicidin, magainin II and ranalexin, alone and in combination with eight clinically used antimicrobial agents was investigated against 12 multidrug-resistant strains of Acinetobacter baumannii isolated from immunocompromised patients. Antimicrobial activities were measured by MIC, MBC and viable count. The peptides had a varied range of inhibitory values: overall, the organisms were more susceptible to buforin II (MIC range 0.25-16 mg/L), cecropin P1 (0.50-32 mg/L) and magainin II (0.50-16 mg/L). Synergy occurred when magainin II was combined with beta-lactam antibiotics.
authors.affiliation: Institute of Infectious Diseases and Public Health, University of Ancona, c/o Azienda Ospedaliera Umberto I, Piazza Cappelli 1, Ancona, Italy. cmalinf@popsci.unian.it
authors.forename: A
authors.initials: A
authors.lastname: Giacometti
authors.forename: O
authors.initials: O
authors.lastname: Cirioni
authors.forename: M S
authors.initials: MS
authors.lastname: Del Prete
authors.forename: F
authors.initials: F
authors.lastname: Barchiesi
authors.forename: A M
authors.initials: AM
authors.lastname: Paggi
authors.forename: E
authors.initials: E
authors.lastname: Petrelli
authors.forename: G
authors.initials: G
authors.lastname: Scalise
mesh_terms: D000150:Acinetobacter / Q000187:drug effects* / Q000276:immunology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology*; D003428:Cross Infection / Q000276:immunology; D018432:Drug Resistance, Multiple / Q000276:immunology; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides