Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein-Barr virus infection.
The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality. Bone Marrow Transplantation (2000) 26, 805-808.
Fujii
N
N
Department of Internal Medicine II, Okayama University Medical School, Okayama, Japan.
Takenaka
K
K
Hiraki
A
A
Maeda
Y
Y
Ikeda
K
K
Shinagawa
K
K
Ashiba
A
A
Munemasa
M
M
Sunami
K
K
Hiramatsu
Y
Y
Ishimaru
F
F
Niiya
K
K
Yoshino
T
T
Harada
M
M
D000328:Adult; D002908:Chronic Disease; D004279:DNA, Viral / Q000097:blood; D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016219:Immunotherapy, Adoptive; D008214:Lymphocytes / Q000821:virology; D008297:Male; D012367:RNA, Viral / Q000097:blood; D013602:T-Lymphocytes, Cytotoxic / Q000637:transplantation; D014184:Transplantation, Homologous
D004279:DNA, Viral; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral