Sonoclot coagulation analysis of in-vitro haemodilution with resuscitation solutions.
The colloid and crystalloid solutions used for resuscitation should preferably be free from effects on coagulation. In 10 volunteers, the effects of haemodilution with various concentrations of 0.9% sodium chloride and 4% succinylated gelatin were assessed by Sonoclot analysis, which describes the whole coagulation process. Small and moderate haemodilution (up to 40%) with 0.9% sodium chloride promoted coagulation. Similar haemodilution with 4% succinylated gelatin impaired coagulation, and at 60% haemodilution coagulation was very poor. These findings need to be confirmed in vivo and their clinical relevance determined.
Brazil
E V
EV
Accident and Emergency Department, Royal London Hospital, Whitechapel, UK.
Coats
T J
TJ
D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005780:Gelatin / Q000494:pharmacology; D006438:Hemodilution; D006801:Humans; D066298:In Vitro Techniques; D010952:Plasma Substitutes / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology; D013386:Succinates / Q000494:pharmacology
D010952:Plasma Substitutes; D013386:Succinates; C060085:succinylated gelatin; D012965:Sodium Chloride; D005780:Gelatin