title: Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK.
abstract: We tested the hypothesis that the release of PYY by fat confined to the proximal small intestine is dependent on CCK. Using a multi-fistulated model, plasma PYY levels were compared in 6 dogs after 60 mM oleate was perfused into the proximal one-half of the small intestine following i.v. administration of saline or devazepide, a CCK-A antagonist. Plasma PYY increased with fat (P < 0. 05), but plasma PYY level was lower following devazepide at 60 min and 90 min (P < 0.05). We conclude that CCK serves as a foregut signal linking fat in the proximal gut with the release of distal gut PYY.
authors.affiliation: Department of Medicine, Burns & Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. henry.lin@cshs.org
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: W Y
authors.initials: WY
authors.lastname: Chey
authors.forename: X
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020109:Devazepide / Q000494:pharmacology; D004285:Dogs; D005223:Fats / Q000008:administration & dosage / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism*; D008954:Models, Biological; D019301:Oleic Acid / Q000008:administration & dosage / Q000494:pharmacology; D019894:Peptide YY / Q000097:blood / Q000378:metabolism*; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors; D013997:Time Factors
chemical_list: D005223:Fats; D043886:Receptor, Cholecystokinin A; D011949:Receptors, Cholecystokinin; D019894:Peptide YY; D019301:Oleic Acid; D002766:Cholecystokinin; D020109:Devazepide