title: Marginal siderosis and degenerative myelopathy: a manifestation of chronic subarachnoid hemorrhage in a horse with a myxopapillary ependymoma.
abstract: Marginal siderosis is recognized in humans as an uncommon clinicopathologic entity characterized by degeneration of neural tissue at the surface of the brain and spinal cord, in association with the accumulation of hemosiderin, and resulting from chronic subarachnoid hemorrhage. The sources of hemorrhage are various and include neoplasms, malformations, cysts, and vasculopathy. Marginal siderosis of the spinal cord due to a myxopapillary ependymoma was diagnosed in a 19-year-old Dutch Warm Blood horse with clinical signs of myelopathy. There is only one previous report of marginal siderosis in the veterinary literature, also in a horse with clinical myelopathy.
authors.affiliation: Department of Biomedical Science, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Huxtable
authors.forename: A
authors.initials: A
authors.lastname: de Lahunta
authors.forename: B A
authors.initials: BA
authors.lastname: Summers
authors.forename: T
authors.initials: T
authors.lastname: Divers
mesh_terms: D000818:Animals; D004806:Ependymoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D005065:Euthanasia / Q000662:veterinary; D006734:Horse Diseases / Q000209:etiology / Q000473:pathology*; D006736:Horses; D008297:Male; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D012806:Siderosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D013116:Spinal Cord / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D013345:Subarachnoid Hemorrhage / Q000209:etiology / Q000473:pathology / Q000662:veterinary*