title: Preventive magnesium supplement reduces ischemia-induced hearing loss and blood viscosity in the guinea pig.
abstract: The effect of magnesium (Mg) on ischemia-induced hearing loss was investigated in two groups of adult pigmented guinea pigs of either an optimal or suboptimal (physiologically high or low) Mg status maintained by different diets. Total Mg concentrations of the perilymph, cerebrospinal fluid, blood plasma and red blood cells were found to differ significantly between the two groups, as tested in a previous study. Local vascular impairment was produced by unilateral ferromagnetic thrombosis of cochlear blood vessels. Cochlear blood flow (CBF) and hearing function were measured using laser Doppler flowmetry and auditory brain-stem response audiometry, respectively. Ferromagnetic thrombosis resulted in significant reductions of the mean apical CBF in both experimental groups and of the mean basal CBF in the low Mg group compared to the contralateral ears. In the high Mg group, the basal CBF was not decreased. However, the laser Doppler signals revealed considerable interindividual variations and the differences found between the two experimental groups were not significant. In contrast, the hearing loss in the low Mg group was significantly higher than that in the high Mg group. A correlation was found to exist between the vascular impairment and the hearing threshold shift. In a separate series, we also tested the effect of Mg on hemorheology and found both the blood viscosity and blood viscoelasticity to be significantly lower in the high Mg group than in the low Mg group, depending on the shear rates tested. The present findings show that a preventive oral Mg supplement can significantly reduce the rate of ischemia-induced hearing loss and improve blood viscosity in the guinea pig.
authors.affiliation: Department of Otorhinolaryngology, Charité Hospital, Humboldt University, Berlin, Germany. fred.scheibe@charite.de
authors.forename: F
authors.initials: F
authors.lastname: Scheibe
authors.forename: H
authors.initials: H
authors.lastname: Haupt
authors.forename: G A
authors.initials: GA
authors.lastname: Vlastos
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects*; D003051:Cochlea / Q000098:blood supply* / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D007511:Ischemia / Q000150:complications* / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry; D008274:Magnesium / Q000627:therapeutic use*
chemical_list: D008274:Magnesium