Regulation of the meiotic cell cycle in oocytes.
The mitotic and meiotic cell cycle share many regulators, but there are also important differences between the two processes. The meiotic maturation of Xenopus oocytes has proved useful for understanding the regulation of Cdc2-cyclin-B, a key activator of G2/M progression. New insights have been made recently into the signalling mechanisms that induce G2-arrested oocytes to resume and complete the meiotic cell cycle.
Nebreda
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AR
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany. nebreda@EMBL-heidelberg.de
Ferby
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D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D019926:Cyclin B / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism; D016195:G2 Phase / Q000502:physiology; D020935:MAP Kinase Signaling System / Q000502:physiology; D008540:Meiosis / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D009865:Oocytes / Q000166:cytology / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D017231:Proto-Oncogene Proteins c-mos / Q000378:metabolism; D016196:S Phase / Q000502:physiology; D014981:Xenopus; D029867:Xenopus Proteins
C099876:CKS2 protein, Xenopus; D018797:Cell Cycle Proteins; D019926:Cyclin B; D016213:Cyclins; D029867:Xenopus Proteins; C119055:ls27 protein, Xenopus; C095970:MYT1 kinase, Xenopus; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; D017231:Proto-Oncogene Proteins c-mos; D016203:CDC2 Protein Kinase