title: [Consideration of drug absorption in customizing drug therapy].
abstract: The rate and extent of drug absorption from the small intestine are related to the release of the active ingredient from a dosage form, its solubility in the liquid phase of gastrointestinal contents, and the transport of the dissolved compound or the intact dosage form from the stomach into the duodenum. With pharmaceutical preparations releasing the active compound within the stomach, and enteric-coated "micro"-formulations (micropellets), gastric emptying is possible during the interdigestive and the digestive period. Potential differences of drug absorption between fasting administration and intake during the digestive period are unpredictable, because they are related to the release characteristics of the dosage form. However, larger enteric-coated preparations like tablets can leave the stomach only with a phase 3 contraction of fasting motility; intake during the digestive period will result in gastric retention of this type of dosage form until all food has left the stomach and fasting motility is restored. Consequently the onset of drug absorption is delayed. This interaction between food and large enteric-coated dosage forms is predictable from pyloric function in relation to the gastric motility. As it occurs regularly, it can be taken into account when prescribing enteric-coated dosage forms. If concomitant intake of food and enteric-coated drugs is unavoidable, but a rapid onset of drug absorption is necessary, micropellets are the dosage form of choice. When the therapeutic effect is insufficient, drug dosage form and timing of drug administration should be checked before prescribing a different active compound.
authors.affiliation: Abteilung Innere Medizin VI, Universität Heidelberg. ingeborg_walter-sack@med.uni-heidelberg.de
authors.forename: I
authors.initials: I
authors.lastname: Walter-Sack
authors.forename: W E
authors.initials: WE
authors.lastname: Haefeli
mesh_terms: D001682:Biological Availability; D004304:Dosage Forms; D004334:Drug Administration Schedule; D011307:Drug Prescriptions; D006801:Humans; D010347:Patient Care Planning; D010599:Pharmacokinetics
chemical_list: D004304:Dosage Forms