title: A decreased serum concentration of nitrite/nitrate correlates with an increased plasma concentration of lactate during and after major surgery.
abstract: A decrease in the production of nitric oxide (NO) due to surgical stress has been reported. We investigated whether this decrease in NO production was related to cytokine induction and/or other clinical parameters. We therefore measured the concentrations of serum nitrite/nitrate (a stable end product of NO), serum interleukin (IL)-6, and standard clinical parameters in 13 patients undergoing major upper abdominal and thoracoabdominal surgery at preanesthesia (PRE), 2h after a surgical incision (2H), at the end of surgery (END), and on the morning of postoperative days 1 (POD 1) and 3 (POD 3). The serum concentration of nitrite/nitrate was thus found to have significantly decreased at END, POD 1, and POD 3 compared with PRE. In addition, the serum nitrite/nitrate concentration correlated negatively with the plasma lactate level, and no relationship was observed between the serum nitrite/nitrate level and either the serum IL-6 level or any other clinical parameters. Our findings thus suggest that the decrease in the serum nitrite/nitrate level might therefore be related to tissue hypoperfusion both during and after major surgery.
authors.affiliation: Department of Anesthesia, Ageo Central General Hospital, Saitama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fujioka
authors.forename: K
authors.initials: K
authors.lastname: Mizumoto
authors.forename: K
authors.initials: K
authors.lastname: Okada
mesh_terms: D000368:Aged; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood*; D011182:Postoperative Care; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology; D019616:Thoracic Surgical Procedures / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D015850:Interleukin-6; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D019344:Lactic Acid