Granulosa cell tumor of the adult type: a case report and review of the literature of a very rare testicular tumor.
We report a case of testicular granulosa cell tumor of the adult type in a 48-year-old man. Microscopically, the tumor consisted of round to ovoid cells with grooved nuclei that were arranged in several patterns, including microfollicular, macrofollicular, insular, trabecular, gyriform, solid, and pseudosarcomatous. These cells demonstrated strong immunopositivity with MIC2 (O13) antibody, vimentin, and smooth muscle actin and focal positivity with cytokeratin. Although this type of sex cord-stromal tumor is relatively common in the ovaries, it is still extremely unusual in the testis, and it probably represents the rarest type of testicular sex cord-stromal tumor.
Al-Bozom
I A
IA
Departments of Pathology, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia.
El-Faqih
S R
SR
Hassan
S H
SH
El-Tiraifi
A E
AE
Talic
R F
RF
D014408:Biomarkers, Tumor / Q000032:analysis; D006106:Granulosa Cell Tumor / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D013736:Testicular Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D014463:Ultrasonography
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins