Suppression of feeding-evoked dopamine release in the rat nucleus accumbens by the blockade of P(2) purinoceptors.
In order to investigate whether endogenous adenosine 5'-triphosphate (ATP) is involved in the regulation of feeding, the influence of the P(2) receptor antagonist pyridoxalphospate-6-azophenyl-2', 4'-disulphonic acid (PPADS) infused into the rat nucleus accumbens on 18-h food-deprived feeding was tested. PPADS suppressed the feeding-induced dopamine release and reduced the amount of food consumed as well as the time of feeding. These results indicate that activation of P(2) purinoceptors by endogenous ATP facilitates feeding behaviour and contributes to the feeding-associated dopamine release.
Kittner
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Rudolf-Boehm-Department of Pharmacology and Toxicology, Universität Leipzig, Härtelstrasse 16-18, D-04107, Leipzig, Germany. kith@medizin.uni-leipzig.de
Krügel
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El-Ashmawy
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Illes
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D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D004435:Eating; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D058919:Purinergic P2 Receptor Antagonists; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018048:Receptors, Purinergic P2 / Q000502:physiology*
D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; C077792:pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; D011732:Pyridoxal Phosphate; D000255:Adenosine Triphosphate; D004298:Dopamine