[A case of hemophagocytosis syndrome with excessive Fe and ferritin concentration in serum and with a good prognosis].
Investigation in the present case began with a high serum Fe concentration. The routine method for determining serum Fe concentration in our hospital is direct photoscopic assay. When we assayed serum Fe concentration by a deproteinization method, it showed a higher value. We also measured serum ferritin concentration, and suspected that high ferritin interfered with serum Fe concentration. We checked the dose-dependent effect of ferritin on serum Fe determination. The present case, a 64-year-old female, showed a reduction of Plt count, and an elevation of LDH, CRP and so on, meeting most of the criteria for hemophagocytosis syndrome. Bone marrow smears revealed phagocytosis of blood cells. The present case had been followed for rheumatoid arthritis and medicated with oral iron pills. In her liver and spleen, high amounts of Fe had accumulated, and excessive Fe was being released into the blood by any trigger, such as infection, stress, cytokine activation, and/or HPS.
Maekawa
M
M
Clinical Laboratory, National Cancer Center Hospital, Tokyo.
Hara
K
K
D000747:Anemia, Hypochromic / Q000150:complications; D001172:Arthritis, Rheumatoid / Q000150:complications; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D007501:Iron / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis
D015415:Biomarkers; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron; D007770:L-Lactate Dehydrogenase