title: Methemoglobinemia after infusion of ifosfamide chemotherapy: first report of a potentially serious adverse reaction related to ifosfamide.
abstract: Acute formation of methemoglobin is a life-threatening condition caused by multiple medications. In this article we report the first case of methemoglobinemia in a patient with metastatic uterine leiomyosarcoma, after infusion of ifosfamide chemotherapy. The patient recovered after prompt diagnosis and treatment of the condition. A mechanism for the formation of methemoglobin as a result of the ifosfamide infusion is offered.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA.
authors.forename: D
authors.initials: D
authors.lastname: Hadjiliadis
authors.forename: J A
authors.initials: JA
authors.lastname: Govert
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous; D007890:Leiomyosarcoma / Q000188:drug therapy*; D008706:Methemoglobin / Q000378:metabolism; D008708:Methemoglobinemia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000188:drug therapy*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D015415:Biomarkers; D008706:Methemoglobin; D007069:Ifosfamide