Differences in experimental virulence of bovine viral diarrhoea viral strains isolated from haemorrhagic syndromes.
In the late 1980s, a new hypervirulent and epidemic form of bovine viral diarrhoea virus (BVDV) infection appeared in North America. A similar but sporadic syndrome was later reported in Europe. To compare the pathogenic characters of the North American and European hypervirulent strains, we inoculated BVDV naïve calves with BVDV strains isolated from haemorrhagic syndromes originating in Belgium, France and the USA. The experimental procedure comprised daily clinical examination and measurement of blood and virological parameters. The American BVD890/256 strain induced severe thrombocytopaenia, profuse diarrhoea and pneumonia in all calves, indicating that hypervirulent BVDV could be the primary infectious agent of pneumonia. Interestingly, a strong correlation was observed between the intense viraemia and a decreased platelet count. None of the European strains tested induced significant pathological signs, although isolated from cases presenting haemorrhagic syndrome.
Hamers
C
C
Department of infectious diseases, Unit of Immunology and Vaccinology, Faculty of Veterinary Medicine, University of Liège, Bld de Colonster, 20 Bat B 43 bis, 4000 Liège, Belgium. chamers@ulg.ac.be
Couvreur
B
B
Dehan
P
P
Letellier
C
C
Lewalle
P
P
Pastoret
P P
PP
Kerkhofs
P
P
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood; D001530:Belgium / Q000453:epidemiology; D001831:Body Temperature; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000472:pathogenicity*; D004906:Erythrocyte Count / Q000662:veterinary; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D005602:France / Q000453:epidemiology; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D006470:Hemorrhage / Q000662:veterinary* / Q000821:virology; D007958:Leukocyte Count / Q000662:veterinary; D009500:Neutralization Tests / Q000662:veterinary; D013577:Syndrome; D013921:Thrombocytopenia / Q000662:veterinary; D014481:United States / Q000453:epidemiology; D014774:Virulence
D000914:Antibodies, Viral; D000956:Antigens, Viral; D006454:Hemoglobins