title: Osteolytic indicators found in total knee arthroplasty synovial fluid aspirates.
abstract: Interleukin-1beta and tartrate resistant acid phosphatase concentrations in synovial fluid aspirates were examined to determine if they could be used as indicators of increased synovial inflammation and an osteolytic reaction in patients having total knee arthroplasty. Synovial aspirates were obtained from seven patients with severely osteoarthritic knees that were scheduled for primary total knee arthroplasty and from 20 patients with knees scheduled for total knee arthroplasty revision. Eleven of the revision cases involved titanium alloy prostheses and nine involved cobalt chrome alloy prostheses. The interleukin-1beta and tartrate resistant acid phosphatase concentrations were obtained and compared between the group having primary total knee arthroplasty and the group having revision total knee arthroplasty. The knees having revision surgery had higher concentrations of interleukin-1beta and tartrate resistant acid phosphatase than did the knees having primary total knee arthroplasty. These results indicate a greater inflammatory and osteolytic response in knees having revision surgery. Although the osteoarthritic knees and the knees needing revision surgery in this study are considered to have an inflammatory state, it was only after total knee arthroplasty when particulate wear debris would be present that appreciable concentrations of interleukin-1beta and tartrate resistant acid phosphatase were produced.
authors.affiliation: Department of Orthopaedic Surgery, Summa Health System, St Thomas Hospital, Akron, OH 44310, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Kovacik
authors.forename: I A
authors.initials: IA
authors.lastname: Gradisar
authors.forename: J J
authors.initials: JJ
authors.lastname: Haprian
authors.forename: T S
authors.initials: TS
authors.lastname: Alexander
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis; D007527:Isoenzymes / Q000032:analysis; D007720:Knee Prosthesis / Q000009:adverse effects; D020370:Osteoarthritis, Knee / Q000378:metabolism / Q000601:surgery; D010014:Osteolysis / Q000175:diagnosis* / Q000209:etiology; D012086:Reoperation; D013582:Synovial Fluid / Q000737:chemistry*; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D015415:Biomarkers; D007375:Interleukin-1; D007527:Isoenzymes; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase