Understanding nuclear receptor function: from DNA to chromatin to the interphase nucleus.
The regulation of gene expression by steroid receptors is the fundamental mechanism by which these important bioregulatory molecules exert their action. As such, mechanisms utilized by receptors in the modulation of genetic expression have been intensively studied since the first identification of hormone-binding proteins. Although these mechanisms include both posttranscriptional (1) and posttranslational (2) components, the primary level of control involves direct modulation of the rate of transcription, and it is this process that has been the major focus of research in the field.
Hager
G L
GL
Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, Maryland 20892-5055, USA.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism* / Q000502:physiology*; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D018390:Gene Targeting; D006801:Humans; D007399:Interphase; D008024:Ligands; D008957:Models, Genetic; D005810:Multigene Family; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011987:Receptors, Steroid / Q000378:metabolism; D015398:Signal Transduction
D002843:Chromatin; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D004247:DNA