Retinoids inhibit bradykinin B1 receptor-sensitized responses in human umbilical vein.
Bradykinin B1 receptors are not expressed under physiological conditions but are induced under inflammatory conditions. In isolated human umbilical vein, a spontaneous bradykinin B1 receptor sensitization process has been demonstrated. On the other hand, retinoids have been shown to exert anti-inflammatory and immunomodulatory actions. We have now examined the effects of all-trans-retinoic acid and 9-cis-retinoic acid on the bradykinin B1 receptor-sensitized responses in human umbilical vein. Both retinoids produced a concentration-dependent rightward shift of the concentration-response curves for the bradykinin B1 receptor agonist, des-Arg(9)-bradykinin. Retinoid treatment did not modify the responses to bradykinin B1 receptor-unrelated agonists, bradykinin or serotonin. In conclusion, retinoids inhibit bradykinin B1 receptor-sensitized responses and this action could participate in their anti-inflammatory and immunomodulatory effects.
Sardi
S P
SP
Departamento de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Piso 15, 1121, Buenos Aires, Argentina.
Rey-Ares
V
V
Pujol-Lereis
V A
VA
Rothlin
R P
RP
D000077556:Alitretinoin; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin / Q000187:drug effects* / Q000502:physiology; D012176:Retinoids / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*; D014471:Umbilical Veins / Q000187:drug effects* / Q000502:physiology
D000970:Antineoplastic Agents; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin; D012176:Retinoids; D000077556:Alitretinoin; D014212:Tretinoin; D001920:Bradykinin