title: Novel translocation of the BCL10 gene in a case of mucosa associated lymphoid tissue lymphoma.
abstract: Interest has focused on a recently identified gene, BCL10, thought to play an important role in the genesis of extranodal, marginal zone (MALT) lymphomas. This gene belongs to a family containing caspase recruitment domains (CARD), that are involved in the apoptotic pathway. Translocations of the BCL10 gene to the immunoglobulin heavy chain locus at 14q32 have been described. We report herein a case of MALT lymphoma showing t(1; 2)(p22; p12). The translocation was shown to involve the BCL10 gene and the immunoglobulin kappa light chain locus by fluorescence in situ hybridization.
authors.affiliation: Molecular Medicine Unit, University of Leeds, Clinical Sciences Building, St. James's University Hospital, Leeds, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Achuthan
authors.forename: S M
authors.initials: SM
authors.lastname: Bell
authors.forename: J P
authors.initials: JP
authors.lastname: Leek
authors.forename: P
authors.initials: P
authors.lastname: Roberts
authors.forename: K
authors.initials: K
authors.lastname: Horgan
authors.forename: A F
authors.initials: AF
authors.lastname: Markham
authors.forename: P J
authors.initials: PJ
authors.lastname: Selby
authors.forename: K A
authors.initials: KA
authors.lastname: MacLennan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D000074018:B-Cell CLL-Lymphoma 10 Protein; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D013160:Splenic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains; D009363:Neoplasm Proteins