title: Changes in lipid profiles in non diabetic, non nephrotic patients commencing continuous ambulatory peritoneal dialysis.
abstract: This study examined the effect on patient lipid profile of commencing continuous ambulatory peritoneal dialysis (CAPD). We followed eighteen non diabetic, non nephrotic patients for 9 months before and after dialysis commencement and compared lipid profiles. Mean cholesterol levels rose from 4.98 mmol/L to 5.42 mmol/L (p < 0.05). This change was chiefly due to a rise in low density lipoprotein (LDL) cholesterol. The LDL cholesterol rose after dialysis commencement and continued to rise up to 9 months later. High-density lipoprotein (HDL) cholesterol remained stable. Serum albumin and body weight fell during follow-up, suggesting that the rise in cholesterol was not a reflection of enhanced nutritional status. This study highlights the pro-atherogenic change in lipids that results from commencing CAPD. This phenomenon is not seen in hemodialysis, and it should be considered when selecting a dialysis modality, given the increased risk of cardiovascular disease in the dialysis population.
authors.affiliation: Department of Renal Medicine, Hope Hospital, Salford, U.K.
authors.forename: E
authors.initials: E
authors.lastname: O'Riordan
authors.forename: D J
authors.initials: DJ
authors.lastname: O'Donoghue
authors.forename: P A
authors.initials: PA
authors.lastname: Kalra
authors.forename: R N
authors.initials: RN
authors.lastname: Foley
authors.forename: S
authors.initials: S
authors.lastname: Waldek
mesh_terms: D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D012709:Serum Albumin / Q000032:analysis; D015431:Weight Loss
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D012709:Serum Albumin; D002784:Cholesterol