title: Intravesical bacillus Calmette-Guerin and dimethyl sulfoxide for treatment of classic and nonulcer interstitial cystitis: a prospective, randomized double-blind study.
abstract: OBJECTIVE
  We conducted a prospective, double-blind study with a crossover design of intravesical bacillus Calmette-Guerin (BCG) and dimethyl sulfoxide to determine whether patients with classic and nonulcer interstitial cystitis, respectively, might benefit from either regimen.
  
  
  METHODS
  A total of 21 patients, including 11 with classic and 10 with nonulcer interstitial cystitis, randomly underwent treatments with intravesical BCG or dimethyl sulfoxide and, if not improved, were treated with the other substance after a washout period. All 21 patients were evaluated with symptom questionnaires, including a visual analog pain scale and voiding diaries.
  
  
  RESULTS
  Regardless of regimen, there was no improvement in maximal functional capacity. There was a reduction in urinary frequency following dimethyl sulfoxide treatment but only in the classic subtype (p <0.05), whereas no reduction was seen following BCG in either subtype. A substantial pain decrease was noted in classic (p <0.05) as well as nonulcer (p <0.05) interstitial cystitis following dimethyl sulfoxide.
  
  
  CONCLUSIONS
  Intravesical BCG has been presented as a promising new option for treatment of interstitial cystitis. We failed to demonstrate benefit from this treatment. Dimethyl sulfoxide had no positive effect on maximal functional capacity but resulted in a significant reduction in pain and urinary frequency, although only in patients with classic interstitial cystitis.
authors.affiliation: Department of Urology, Sahlgrenska University Hospital Göteborg, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Peeker
authors.forename: M A
authors.initials: MA
authors.lastname: Haghsheno
authors.forename: S
authors.initials: S
authors.lastname: Holmäng
authors.forename: M
authors.initials: M
authors.lastname: Fall
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D001500:BCG Vaccine / Q000008:administration & dosage*; D018592:Cross-Over Studies; D018856:Cystitis, Interstitial / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D014563:Urodynamics
chemical_list: D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D004121:Dimethyl Sulfoxide