title: Resolution of refractory hepatic hydrothorax after chemical pleurodesis with minocycline.
abstract: Management of refractory hepatic hydrothorax is a challenge to physicians in clinical practice. We reported two patients with hepatic hydrothorax, non-alcoholic cirrhosis and rapidly recurring pleural effusion. They failed to improve with diuretics and repeated thoracentesis. Refractory hepatic hydrothorax was successfully treated by minocycline-induced pleural symphysis. After pleurodesis, ventilatory function returned to normal in both patients. No recurrence of pleural effusion was noted. We suggest that minocycline pleurodesis is an alternative treatment for refractory hepatic hydrothorax because it is simple, safe and effective.
authors.affiliation: Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC.
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: J C
authors.initials: JC
authors.lastname: Wu
authors.forename: S C
authors.initials: SC
authors.lastname: Chang
authors.forename: Y H
authors.initials: YH
authors.lastname: Huang
authors.forename: T I
authors.initials: TI
authors.lastname: Huo
authors.forename: F Y
authors.initials: FY
authors.lastname: Chang
authors.forename: S D
authors.initials: SD
authors.lastname: Lee
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D006801:Humans; D006876:Hydrothorax / Q000503:physiopathology / Q000628:therapy*; D008103:Liver Cirrhosis / Q000150:complications*; D008168:Lung / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D018700:Pleurodesis
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline