Tabletted polylactide microspheres prepared by a w/o emulsion-spray drying method.
An emulsification-spray drying technique is used to prepare poly(D,L-lactic acid) (PDLLA) microparticles loaded with a water soluble, non-steroidal anti-inflammatory drug (NSAID), sodium naproxen (NaNPX). The method involves the preparation of a w/o emulsion in which the water soluble drug is dissolved in the aqueous dispersed phase, while the polymer is dissolved in the organic continuous phase. As a comparison, microparticles were prepared by spraying a suspension of the drug into an organic solution of the polymer. The spray-dried particles were characterized using SEM, DSC, XRD and in vitro release tests. The spray-dried product was then compressed (direct compression) to obtain controlled release matrix tablets. All microparticles release NaNPX within 30 min. The matrix tablets release the drug in 8-10 h; the matrix tablets characterized by the presence of surfactant (due to the emulsion used to obtain the microparticles) have the highest release rate.
Giunchedi
P
P
Dipartimento di Scienze del Farmaco, Università di Sassari, Italy. pgiume@ssmain.uniss.it
Gavini
E
E
Bonacucina
G
G
Palmieri
G F
GF
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D002214:Capsules; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D004655:Emulsions; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009288:Naproxen / Q000008:administration & dosage / Q000493:pharmacokinetics; D011091:Polyesters; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D002214:Capsules; D003692:Delayed-Action Preparations; D004655:Emulsions; D011091:Polyesters; D013607:Tablets; C033616:poly(lactide); D009288:Naproxen