title: Community acquired pneumonia--a prospective UK study.
abstract: BACKGROUND
  There are few data on paediatric community acquired pneumonia (PCAP) in the UK.
  
  
  OBJECTIVE
  To investigate the aetiology and most useful diagnostic tests for PCAP in the north east of England.
  
  
  METHODS
  A prospective study of hospital admissions with a diagnosis of PCAP.
  
  
  RESULTS
  A pathogen was isolated from 60% (81/136) of cases, and considered a definite or probable cause of their pneumonia in 51% (70/136). Fifty (37%) had a virus implicated (65% respiratory syncytial virus) and 19 (14%) a bacterium (7% group A streptococcus, 4% Streptococcus pneumoniae), with one mixed infection. Of a subgroup (51 patients) in whom serum antipneumolysin antibody testing was performed, 6% had evidence of pneumococcal infection, and all were under 2 years old. The best diagnostic yield was from paired serology (34%, 31/87), followed by viral immunofluorescence (33%, 32/98).
  
  
  CONCLUSIONS
  Viral infection accounted for 71% of the cases diagnosed. Group A streptococcus was the most common bacterial infective agent, with a low incidence of both Mycoplasma pneumoniae and S pneumoniae. Pneumococcal pneumonia was the most common bacterial cause of pneumonia in children under 2 years but not in older children. Inflammatory markers and chest x ray features did not differentiate viral from bacterial pneumonia; serology and viral immunofluorescence were the most useful diagnostic tests.
authors.affiliation: Department of Paediatrics, Newcastle General Hospital, Westgate Road, Newcastle-upon-Tyne, UK. paula@medmail.com
authors.forename: P
authors.initials: P
authors.lastname: Drummond
authors.forename: J
authors.initials: J
authors.lastname: Clark
authors.forename: J
authors.initials: J
authors.lastname: Wheeler
authors.forename: A
authors.initials: A
authors.lastname: Galloway
authors.forename: R
authors.initials: R
authors.lastname: Freeman
authors.forename: A
authors.initials: A
authors.lastname: Cant
mesh_terms: D000293:Adolescent; D001419:Bacteria / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000382:microbiology; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018410:Pneumonia, Bacterial / Q000175:diagnosis* / Q000382:microbiology; D011024:Pneumonia, Viral / Q000175:diagnosis* / Q000821:virology; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012698:Serologic Tests; D014780:Viruses / Q000302:isolation & purification