Can the creatinine dialysate-to-plasma ratio from the peritoneal equilibration test be replaced by the sodium dialysate-to-plasma ratio and the sodium level in the dialysate?
The peritoneal equilibration test (PET) is a useful tool that categorizes peritoneal transport. However, the method has some inconveniences. Some authors suggest that measuring the sodium level in the dialysate (NaD) or the dialysate-to-plasma ratio for sodium (D/PNa) can substitute for the PET. We applied a mathematical analysis [Fisher intraclass correlation coefficient (FICC)] to 43 PETs performed in 43 peritoneal dialysis patients (29 males, 14 females) with a mean age of 55.3 years (range: 28-85 years). Determinations of NaD, of sodium level in plasma (NaP), and of D/PNa at times 0, 30, 60, 120, and 240 minutes were added to the usual PET determinations. After using the NaD240 and the D/PNa240 values to calculate the cut-off values for the various peritoneal transport categories, we obtained a transport distribution very similar to that of the PET dialysate-to-plasma ratio for creatinine after 240 minutes (D/PCr240). At the same time, the FICC showed good (0.69) and excellent (0.77) correlation of NaD240 and D/PNa240 respectively with the D/PCr240. Therefore either of these two methods, which are cheaper and quicker than a PET, can be used to categorize peritoneal transport with a high degree of reliability.
García
R
R
Unidad de Diálisis Peritoneal, Hospital Clínico Universitario, Valencia, Spain.
Miguel
A
A
Oviedo
M
M
Martínez
A
A
Esteve
S
S
Pérez-Contreras
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000378:metabolism*; D015314:Dialysis Solutions / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D012964:Sodium / Q000032:analysis / Q000378:metabolism*
D015314:Dialysis Solutions; D012964:Sodium; D003404:Creatinine