title: Entering through the doors of perception: characterization of a highly selective Substance P receptor-targeted toxin.
abstract: Perception of external stimuli is often mediated through the activity of a G protein-coupled receptor in response to its ligand. Receptor-mediated internalization allows the insertion of toxins that cause the elimination of receptor-expressing neurons. Using this technique new information on systems biology can be discovered and with this, new therapeutics developed.
authors.affiliation: Advanced Targeting Systems, San Diego, USA. targeting@ATSbio.com
authors.forename: D A
authors.initials: DA
authors.lastname: Lappi
authors.forename: R G
authors.initials: RG
authors.lastname: Wiley
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics*; D004705:Endocytosis / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism*; D000922:Immunotoxins; D009699:N-Glycosyl Hydrolases; D010940:Plant Proteins / Q000493:pharmacokinetics*; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D054789:Ribosome Inactivating Proteins, Type 1; D000076985:Saporins; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000922:Immunotoxins; D010940:Plant Proteins; D018040:Receptors, Neurokinin-1; D054789:Ribosome Inactivating Proteins, Type 1; D009699:N-Glycosyl Hydrolases; D000076985:Saporins; D019204:GTP-Binding Proteins