[Advances in the experimental study on the role of helper T cell subsets in the pathogenesis and the treatment of autoimmune diseases].
In this paper the functions of helper T(Th) cell subsets, their cross regulation and agents affected their differentiation, as well as the role of Th subsets in the possible pathogenesis of autoimmune diseases were reviewed. Furthermore, a lot of opinions on autoimmune diseases therapy through restoration of Th subsets balance were mentioned. The available measurements to be used include up-regulation of CD1d, administration of relative cytokines, administration of Freund adjuvant, administration of monoclonal antibodies against cytokines, cytokine receptors, CD40 ligand or B7 molecule, as well as CTLA or CTLAIg pathway and so on.
Wang
Q B
QB
Department of Immunology, China-Japan Friendship Institute of Clinical Medical Sciences, Beijing.
Zhao
W S
WS
D001327:Autoimmune Diseases / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*