Adhesion complexes implicated in intestinal epithelial cell-matrix interactions.
This article review summarizes data on cell-substratum adhesion complexes involved in the regulation of cellular functions in the intestine. We first focus on the molecular composition of the two main adhesion structures-the beta1 integrin-adhesion complex and the hemidesmosome-found in vivo and in two human intestinal cell lines. We also report the key findings on the cellular behavior and response to the extracellular matrix that involve integrins, the main transmembrane anchors of these complexes. How the dynamics of cell/extracellular matrix interactions contribute to cell migration, proliferation, differentiation, and tumorigenicity is discussed in the light of the data provided by the human intestinal cells.
Stutzmann
J
J
INSERM Research Unit 381, Ontogenesis and Pathology of the Digestive System, 67200 Strasbourg, France.
Bellissent-Waydelich
A
A
Fontao
L
L
Launay
J F
JF
Simon-Assmann
P
P
D018938:Caco-2 Cells; D002448:Cell Adhesion; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic; D005109:Extracellular Matrix / Q000378:metabolism*; D019073:HT29 Cells; D022002:Hemidesmosomes / Q000378:metabolism; D006801:Humans; D019012:Integrin beta1 / Q000032:analysis / Q000378:metabolism*; D016023:Integrins / Q000032:analysis / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D018613:Microscopy, Confocal
D019012:Integrin beta1; D016023:Integrins