title: Effect of a new international reference preparation for proteins in human serum (certified reference material 470) on results of the College of American Pathologists Surveys for plasma proteins.
abstract: OBJECTIVE
  To examine the impact of a new international reference preparation for serum proteins on the among-manufacturer variance in the College of American Pathologists Surveys.
  
  
  METHODS
  The results of the Surveys for the years 1993-1998, supplied by the College of American Pathologists.
  
  
  METHODS
  Mean values for manufacturers' assays were compared for each protein in the quality control samples. Results were separated by the reported reference material from which values for calibrators had been transferred. Standard statistical parameters (means, standard deviations, and coefficients of variation) were calculated from the reported means.
  
  
  CONCLUSIONS
  Among-manufacturer coefficients of variation have dropped significantly for most serum proteins since the introduction of the new reference material. Possible reasons for continued differences are discussed.
authors.affiliation: Committee on Plasma Proteins, International Federation for Clinical Chemistry, Chapel Hill, NC, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Johnson
authors.forename: J T
authors.initials: JT
authors.lastname: Whicher
authors.forename: T B
authors.initials: TB
authors.lastname: Ledue
authors.forename: A
authors.initials: A
authors.lastname: Carlström
authors.forename: Y
authors.initials: Y
authors.lastname: Itoh
authors.forename: P H
authors.initials: PH
authors.lastname: Petersen
mesh_terms: D000418:Albumins / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis / Q000592:standards*; D002097:C-Reactive Protein / Q000032:analysis; D002568:Certification; D002570:Ceruloplasmin / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D010338:Pathology, Clinical / Q000592:standards*; D011786:Quality Control; D012015:Reference Standards; D015203:Reproducibility of Results; D012955:Societies, Medical; D014168:Transferrin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000418:Albumins; D001798:Blood Proteins; D003176:Complement C3; D003181:Complement C4; D006242:Haptoglobins; D007136:Immunoglobulins; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein; D002570:Ceruloplasmin