Hypogonadotropic hypogonadism: retrospective analysis of 19 cases.
OBJECTIVE
To survey the clinical data of patients with isolated gonadotropin deficiency.


METHODS
We retrospectively surveyed the medical records of 19 patients with isolated gonadotropin deficiency aged 16-31 years (mean: 20 years). The major complaint was primary amenorrhea in 100% of the patients, with 42.1% of them also reporting absence of secondary sex traits, and 10% reporting anosmia or hyposmia. Seventy-four percent of the patients had been submitted to hormonal replacement therapy.


RESULTS
Bone densitometry was determined in 5 patients and revealed lumbar spine osteopenia in 3 patients and femoral osteopenia in 1. An association with urologic malformations was detected in 10.5% of cases and an association with gynecologic malformations was detected in 31.6%.


CONCLUSIONS
Isolated gonadotropin deficiency can be easily diagnosed but requires early estrogen replacement therapy because of a higher risk of osteopenia and consequently of osteoporosis. Concomitant urogenital malformations are frequent and should be investigated.
Moura
M D
MD
Department of Gynecology and Obstetrics, University of São Paulo, Ribeirão Preto, Brazil. mddmoura@fmrp.usp.br
Navarro
P A
PA
Silva de Sá
M F
MF
Ferriani
R A
RA
Unzer
S M
SM
Reis
R M
RM
D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D015914:Estrogen Replacement Therapy / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007006:Hypogonadism / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D008499:Medical Records; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control; D012189:Retrospective Studies; D014564:Urogenital Abnormalities / Q000209:etiology