Morphological identification of the patterns of prostatic intraepithelial neoplasia and their importance.
High grade prostatic intraepithelial neoplasia (PIN) is the most likely precursor of prostatic carcinoma. PIN has a high predictive value as a marker for carcinoma, and its identification in biopsy specimens warrants repeat biopsy for concurrent or subsequent carcinoma. The only methods of detection are biopsy and transurethral resection; PIN does not greatly raise the concentration of serum prostate specific antigen (PSA) or its derivatives, does not induce a palpable mass, and cannot be detected by ultrasound. Androgen deprivation decreases the prevalence and extent of PIN, suggesting that this form of treatment might play a role in chemoprevention. Radiotherapy is also associated with a decreased incidence of PIN.
Montironi
R
R
Institute of Pathological Anatomy and Histopathology, University of Ancona, Ospedale Regionale, Italy. r.montironi@popcsi.unian.it
Mazzucchelli
R
R
Algaba
F
F
Lopez-Beltran
A
A
D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D019048:Prostatic Intraepithelial Neoplasia / Q000145:classification / Q000473:pathology* / Q000628:therapy; D011471:Prostatic Neoplasms / Q000145:classification / Q000473:pathology* / Q000628:therapy