Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration.
Transnasal absorption of pharmaceutical drugs has been recognized as an interesting alternative to the more conventional routes of administration. The aim of this paper was to develop a method of administrating L-dopa following the transnasal route. Gelatin microspheres were prepared by the w/o emulsification solvent extraction technique: the microspheres had a median particle size of 16.2 +/- 4.2 microm and were prepared using a stirring speed of 600 rpm for 5 min at 80 degrees C. The microspheres obtained were spherical and smooth-surfaced, and the microsphere size was inversely proportional to stirring speed (300-700 rpm) and to the percentage of the emulsifier (Tween 85, 1.4-2.7% v/v). L-dopa was incorporated into the microspheres with an efficiency of 65 +/- 6.7%. L-dopa was released from the microspheres, showing an initial fast release rate, followed by a second slower release rate.
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Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Complutense University of Madrid, Spain. begonab@eucmos.sim.ucm.es
Ballesteros
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Frutos
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D000042:Absorption; D000281:Administration, Intranasal; D000978:Antiparkinson Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002214:Capsules; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems; D005780:Gelatin; D006801:Humans; D066298:In Vitro Techniques; D007980:Levodopa / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size
D000978:Antiparkinson Agents; D002214:Capsules; D007980:Levodopa; D005780:Gelatin