title: On 3-D graphical representation of DNA primary sequences and their numerical characterization.
abstract: In this article we (1) outline the construction of a 3-D "graphical" representation of DNA primary sequences, illustrated on a portion of the human beta globin gene; (2) describe a particular scheme that transforms the above 3-D spatial representation of DNA into a numerical matrix representation; (3) illustrate construction of matrix invariants for DNA sequences; and (4) suggest a data reduction based on statistical analysis of matrix invariants generated for DNA. Each of the four contributions represents a novel development that we hope will facilitate comparative studies of DNA and open new directions for representation and characterization of DNA primary sequences.
authors.affiliation: National Institute of Chemistry, Ljubljana, Slovenia.
authors.forename: M
authors.initials: M
authors.lastname: Randić
authors.forename: M
authors.initials: M
authors.lastname: Vracko
authors.forename: A
authors.initials: A
authors.lastname: Nandy
authors.forename: S C
authors.initials: SC
authors.lastname: Basak
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D005091:Exons; D005914:Globins / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data
chemical_list: D005914:Globins; D004247:DNA