title: Combined preoperative chemotherapy and radiation for locally advanced rectal carcinoma.
abstract: To determine the efficacy of combined preoperative chemotherapy and radiation therapy for locally advanced rectal carcinoma and the rate of sphincter conservation, a retrospective survey of 39 patients with locally advanced rectal carcinoma treated with various 5-fluorouracil- and leukovorin-based chemotherapy regimens and radiation prior to surgery in a single institution was reviewed. Toxicity, local control and survival were evaluated and compared to previous studies with similarly staged patients. Long-term follow-up was available on 35 patients. The actuarial local failure was 5.7% while the actuarial 5-year survival was 87%. The mortality rate was low (2.5%) and the rate of long-term serious complications acceptable (11.4%). Combined preoperative chemotherapy and radiation provided excellent local regional control despite the poor prognostic factors associated with size, fixation, and the initial advanced tumor stage with acceptable morbidity. In addition, patients with tumors located in the lower third of the rectum may be able to undergo sphincter-sparing surgery. Although the median follow-up is relatively short (32.4 months), the results are in accordance with previous studies of neoadjuvant combined chemotherapy and radiation for locally advanced rectal carcinoma in terms of local and distant control.
authors.affiliation: Department of Radiation/Oncology, Southwestern University, VA North Texas Health Care System, Dallas 75216, USA.
authors.forename: N P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: S
authors.initials: S
authors.lastname: Sallah
authors.forename: U
authors.initials: U
authors.lastname: Karlsson
authors.forename: A
authors.initials: A
authors.lastname: Ludin
authors.forename: P
authors.initials: P
authors.lastname: Vos
authors.forename: P
authors.initials: P
authors.lastname: Lepera
authors.forename: G
authors.initials: G
authors.lastname: Jendrasiak
authors.forename: W
authors.initials: W
authors.lastname: Chapman
authors.forename: C
authors.initials: C
authors.lastname: Robiou
authors.forename: M
authors.initials: M
authors.lastname: Salehpour
mesh_terms: D001003:Anal Canal / Q000502:physiology; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D011882:Radiotherapy, High-Energy; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil