title: Isolated splenic lymphoma: an elusive preoperative diagnosis.
abstract: Four patients underwent splenectomy for various clinical and radiological diagnoses and were found to have primary splenic lymphoma at surgery and histology. The diagnosis was classical Hodgkin's lymphoma, mixed cellularity type (one case); marginal zone B-cell non-Hodgkin's lymphoma (one case); and large B cell type non-Hodgkin's lymphoma (two cases). The first two patients had multiple nodules in the spleen measuring 0.1-0.5 cm while large cell lymphomas had large nodules (largest measuring 11 cm x 7 cm x 4 cm). The diagnoses were confirmed by immunohistochemical analysis. Mean follow up of these patients was 11 months; all patients received chemotherapy. One patient died, of causes not related to the disease process.
authors.affiliation: Department of Surgery, Seth G S Medical College, Mumbai.
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: V
authors.initials: V
authors.lastname: Thapar
authors.forename: R
authors.initials: R
authors.lastname: Prabhu
authors.forename: K
authors.initials: K
authors.lastname: Naresh
authors.forename: A
authors.initials: A
authors.lastname: Joshi
authors.forename: A
authors.initials: A
authors.lastname: Supe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D017024:Chemotherapy, Adjuvant; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007432:Intraoperative Period; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D013156:Splenectomy / Q000379:methods / Q000401:mortality; D013158:Splenic Diseases / Q000175:diagnosis* / Q000601:surgery*; D013163:Splenomegaly / Q000473:pathology; D016896:Treatment Outcome