title: A destructive hemispheric cleft discovered in a female fetus.
abstract: The case of a female fetus who died at the 38th week of gestation is reported. Neuropathological examination disclosed a hemispheric cleft located in the medial part of the left frontal lobe. The cleft did not extend to the ventricle and was not a true schizencephaly. Furthermore, a focus of gliosis was evidenced by GFAP staining located in the superior bank of the cleft suggesting a destructive origin of the process. Maternal psychological stress occurring during the middle of the pregnancy could have favored hemodynamic disturbances acting on the fetal circulation.
authors.affiliation: Service d'Histologie, Embryologie et Cytogénétique, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Catala
authors.forename: M
authors.initials: M
authors.lastname: Bucourt
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D005260:Female; D005313:Fetal Death / Q000473:pathology*; D005625:Frontal Lobe / Q000002:abnormalities* / Q000098:blood supply / Q000737:chemistry; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005911:Gliosis / Q000473:pathology; D006801:Humans; D008578:Meninges / Q000002:abnormalities / Q000737:chemistry; D021041:Placental Circulation; D011247:Pregnancy; D013315:Stress, Psychological / Q000473:pathology
chemical_list: D005904:Glial Fibrillary Acidic Protein