title: An intra-articular method for assessing topical application to a synovial joint.
abstract: Intra-articular injection of drugs is increasingly used in human medicines. We report a method for the direct administration of a test substance to the synovial fluid of the canine stifle joint. This method caused little distress or pathology, making it suitable for pre-clinical assessment of new drugs in dogs and other species.
authors.affiliation: Covance Laboratories Limited, Harrogate, UK.
authors.forename: T
authors.initials: T
authors.lastname: Holland
authors.forename: R
authors.initials: R
authors.lastname: Jones
authors.forename: A
authors.initials: A
authors.lastname: Basford
authors.forename: T
authors.initials: T
authors.lastname: Child
authors.forename: A
authors.initials: A
authors.lastname: Smith
mesh_terms: D000818:Animals; D018501:Antirheumatic Agents / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D007270:Injections, Intra-Articular / Q000379:methods*; D007719:Knee Joint / Q000187:drug effects* / Q000473:pathology; D012965:Sodium Chloride / Q000008:administration & dosage; D013583:Synovial Membrane / Q000187:drug effects / Q000473:pathology; D013585:Synovitis / Q000139:chemically induced / Q000473:pathology
chemical_list: D018501:Antirheumatic Agents; D012965:Sodium Chloride