title: Dose-finding study of triptorelin acetate for prevention of a premature LH surge in IVF: a prospective, randomized, double-blind, placebo-controlled study.
abstract: Gonadotrophin-releasing hormone agonists (GnRHa) are routinely used in IVF programmes to prevent an unwanted LH surge and consequent ovulation. Despite its widespread use in IVF, a convincing dose recommendation for GnRHa in IVF does not exist. In our opinion, the lowest possible dose of GnRHa should be used. Thus, we performed a prospective, randomized, double-blind, placebo-controlled study to determine the minimal daily dose of triptorelin acetate needed to suppress a premature LH surge during IVF treatment in a long protocol. A total of 240 women (60 in each group) was randomized to either placebo or to one of three doses of triptorelin, i.e. 15, 50 or 100 microg daily. Ovarian stimulation was performed with two or three ampoules of FSH daily. A premature LH surge occurred in 23% of placebo-treated patients, but in none of the triptorelin acetate-treated patients. There were significantly more oocytes and embryos in the 50 and 100 microg triptorelin groups. There was no dose relationship in rates of either implantation, pregnancy, ongoing pregnancy, live birth or baby take-home. In this study we showed that daily administration of 15 microg triptorelin is sufficient to prevent a premature LH surge, and that 50 microg is equivalent to 100 microg in terms of IVF results.
authors.affiliation: Research Institute for Endocrinology, Reproduction and Metabolism, IVF Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: Janssens
authors.forename: C B
authors.initials: CB
authors.lastname: Lambalk
authors.forename: J P
authors.initials: JP
authors.lastname: Vermeiden
authors.forename: R
authors.initials: R
authors.lastname: Schats
authors.forename: J M
authors.initials: JM
authors.lastname: Bernards
authors.forename: L T
authors.initials: LT
authors.lastname: Rekers-Mombarg
authors.forename: J
authors.initials: J
authors.lastname: Schoemaker
mesh_terms: D002452:Cell Count; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004622:Embryo, Mammalian; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D009865:Oocytes / Q000473:pathology; D010053:Ovary / Q000503:physiopathology; D010919:Placebos; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
chemical_list: D010919:Placebos; D017329:Triptorelin Pamoate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone