Mater, a maternal effect gene required for early embryonic development in mice.
Maternal effect genes produce mRNA or proteins that accumulate in the egg during oogenesis. We show here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential for embryonic development beyond the two-cell stage. Females lacking the maternal effect gene Mater are sterile. Null males are fertile.
Tong
Z B
ZB
Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland, USA.
Gold
L
L
Pfeifer
K E
KE
Dorward
H
H
Lee
E
E
Bondy
C A
CA
Dean
J
J
Nelson
L M
LM
D000818:Animals; D000941:Antigens; D001755:Blastocyst / Q000473:pathology; D004527:Egg Proteins / Q000235:genetics / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D005327:Fetal Resorption / Q000235:genetics; D005796:Genes; D018392:Genomic Imprinting / Q000235:genetics*; D007247:Infertility, Female / Q000235:genetics; D016350:Leucine Zippers / Q000235:genetics / Q000502:physiology; D051379:Mice / Q000196:embryology / Q000235:genetics*; D018345:Mice, Knockout; D009865:Oocytes / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D023121:RNA, Messenger, Stored / Q000235:genetics
D000941:Antigens; D004527:Egg Proteins; C416503:Nalp5 protein, mouse; D023121:RNA, Messenger, Stored