Clinicopathologic correlation of fluorescein and indocyanine green angiography in exudative age-related macular degeneration.
OBJECTIVE
To correlate the clinical and histopathologic features of an eye with age-related macular degeneration studied with fluorescein (FA) and indocyanine green (ICG) angiography 4.5 months before the patient's death.


METHODS
Histopathologic features from serial sections through the macula of a 76-year-old man with occult choroidal neovascularization (CNV) were reconstructed in a scaled two-dimensional map and compared with FA and ICG angiogram images obtained 4.5 months before his death.


RESULTS
The region of prior laser photocoagulation was identified as a well-demarcated hypofluorescent region in the early frames of the FA and the early and late phases of the ICG angiogram. This corresponded histopathologically to a well-circumscribed area of absence of the choriocapillaris, loss of the outer retina and retinal pigment epithelium, and scarring of the choroid. Occult CNV characterized by elevated late hyperfluorescence on the FA and intense well-defined hyperfluorescence on the ICG angiogram corresponded to a thick fibrovascular membrane in the subretinal space and within Bruch's membrane. Thin extensions of both the subretinal and intra-Bruch's membrane fibrovascular membrane components corresponded to nonelevated stippled late hyperfluorescence on the FA and mild late hyperfluorescence on the ICG angiogram.


CONCLUSIONS
Histopathologic mapping revealed a large fibrovascular complex located subretinally and within Bruch's membrane with thin and thick components that correlate well with findings of occult CNV on FA and ICG angiography.
Lauer
A K
AK
Macular Degeneration Center and Leonard Christenen Eye Pathology Laboratory, Casey Eye Institute, Oregon Health Sciences University, Portland 97201-4197, USA.
Wilson
D J
DJ
Klein
M L
ML
D000368:Aged; D016570:Bruch Membrane / Q000473:pathology; D020256:Choroidal Neovascularization / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005122:Exudates and Transudates; D019793:Fluorescein; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D017075:Laser Coagulation; D008268:Macular Degeneration / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008297:Male; D012160:Retina / Q000473:pathology; D014792:Visual Acuity
D007208:Indocyanine Green; D019793:Fluorescein