title: Three decades of allogeneic bone marrow transplants at the Princess Margaret Hospital.
abstract: A total of 1,122 patients with various hemopoietic disorders were transplanted at the Princess Margaret Hospital since 1970. The majority suffered from acute or chronic myeloid leukemia. Improvements in support strategies permitted a gradual escalation of the upper age limit for transplant candidates and resulted in better survival. The overall survival at 10 years of all patients transplanted consecutively either before or after 1986 increased from 30 to 50%. This change was observed independent of other transplant related risk factors and is predominantly attributable to the use of cyclosporine and ganciclovir. An improvement of similar magnitude was seen for transplant recipients presenting with good risk features. The 10-year survival of patients with acute and chronic myeloid leukemia transplanted from a fully matched sibling donor in first complete remission or first chronic phase increased from 40 to approximately 70%. The quality of life of surviving patients may not return to normal but appears to improve with time after the transplant.
authors.affiliation: Princess Margaret Hospital, Toronto, Ontario, Canada.
authors.forename: H A
authors.initials: HA
authors.lastname: Messner
authors.forename: J E
authors.initials: JE
authors.lastname: Curtis
authors.forename: J L
authors.initials: JL
authors.lastname: Lipton
authors.forename: J M
authors.initials: JM
authors.lastname: Meharchand
authors.forename: M D
authors.initials: MD
authors.lastname: Minden
authors.forename: A
authors.initials: A
authors.lastname: Panzarella
mesh_terms: D016026:Bone Marrow Transplantation / Q000401:mortality / Q000502:physiology / Q000706:statistics & numerical data*; D002423:Cause of Death; D005500:Follow-Up Studies; D006085:Graft Survival; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000532:radiotherapy / Q000628:therapy*; D015470:Leukemia, Myeloid, Acute / Q000532:radiotherapy / Q000628:therapy*; D016609:Neoplasms, Second Primary / Q000453:epidemiology; D009864:Ontario; D010166:Palliative Care; D011183:Postoperative Complications / Q000145:classification / Q000453:epidemiology; D011788:Quality of Life; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014916:Whole-Body Irradiation