title: Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors.
authors.affiliation: Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Sebti
authors.forename: A D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D020690:GTPase-Activating Proteins / Q000378:metabolism; D006801:Humans; D017368:Protein Prenylation / Q000187:drug effects*; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
chemical_list: D020690:GTPase-Activating Proteins; C116071:rap1a-GTPase activating proteins, human; C485482:smg p21 GAP1 protein, human; C485483:smg p21 GAP2 protein, human; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; C064911:p21(ras) farnesyl-protein transferase; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein