Combination studies between polycationic peptides and clinically used antibiotics against Gram-positive and Gram-negative bacteria.
The in vitro interaction between five polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, using the microbroth dilution method. The combination studies showed synergy between ranalexin and polymyxin E, doxycycline and clarithromycin. In addition, magainin II was shown to be synergic with betalactam antibiotics.
Giacometti
A
A
Department of Infectious Diseases, Institute of Infectious Diseases and Public Health, University of Ancona, I-60121 Ancona, Italy. cmalinf@popsci.unian.it
Cirioni
O
O
Del Prete
M S
MS
Paggi
A M
AM
D'Errico
M M
MM
Scalise
G
G
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D017291:Clarithromycin / Q000378:metabolism; D003091:Colistin / Q000378:metabolism; D004318:Doxycycline / Q000378:metabolism; D004347:Drug Interactions; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D006094:Gram-Positive Bacteria / Q000378:metabolism*; D007769:Lactams; D054806:Magainins; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D013211:Staphylococcus aureus / Q000378:metabolism; D029867:Xenopus Proteins
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D007769:Lactams; D054806:Magainins; D010455:Peptides; D010456:Peptides, Cyclic; D011506:Proteins; D029867:Xenopus Proteins; C097849:buforin II; C073143:indolicidin; C053301:magainin 2 peptide, Xenopus; C086618:ranalexin; D017291:Clarithromycin; D004318:Doxycycline; C070016:cecropin P1-LI; D003091:Colistin