title: [Clinically relevant adverse drug interactions].
abstract: Drug interactions may lead to adverse drug effects or therapeutic failure. Many clinically relevant unwanted interactions are caused by a change in the activity of cytochrome P450 isoenzymes or the activity of active drug transport systems (e.g. p-glycoprotein). Most drug interactions may be anticipated and prevented by dose modification or using alternative drugs.
authors.affiliation: Abteilung Innere Medizin VI, Universitätsklinikum Heidelberg. meret_martin-facklam@med.uni-heidelberg.de
authors.forename: M
authors.initials: M
authors.lastname: Martin-Facklam
authors.forename: W E
authors.initials: WE
authors.lastname: Haefeli
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004347:Drug Interactions; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System