title: Toxoplasma gondii Hsp70 as a danger signal in toxoplasma gondii-infected mice.
abstract: Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-gamma knockout mice infected with T gondii. Tgondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.
authors.affiliation: Department of Parasitology, Chiba University School of Medicine, Japan.
authors.forename: H S
authors.initials: HS
authors.lastname: Mun
authors.forename: F
authors.initials: F
authors.lastname: Aosai
authors.forename: K
authors.initials: K
authors.lastname: Norose
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Hata
authors.forename: Y I
authors.initials: YI
authors.lastname: Tagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Iwakura
authors.forename: D S
authors.initials: DS
authors.lastname: Byun
authors.forename: A
authors.initials: A
authors.lastname: Yano
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan; D050890:HSP30 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000302:isolation & purification*; D006360:Heat-Shock Proteins / Q000235:genetics / Q000302:isolation & purification; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000235:genetics / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009569:Nitric Oxide / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics / Q000302:isolation & purification*; D012333:RNA, Messenger / Q000302:isolation & purification; D016053:RNA, Protozoan / Q000302:isolation & purification; D014124:Toxoplasmosis, Animal / Q000401:mortality*
chemical_list: D000953:Antigens, Protozoan; C106179:BAG1 protein, Toxoplasma; D050890:HSP30 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; D015800:Protozoan Proteins; D012333:RNA, Messenger; D016053:RNA, Protozoan; C047168:SAG1 antigen, Toxoplasma; D009569:Nitric Oxide; D007371:Interferon-gamma