Iron- and aluminum-induced carcinogenesis.
Ferric and aluminum complexes with ATP have shown the induction of tumors in the site of subcutaneous injection, whereas sodium ATP has not. A concomitant but apparently independent phenomenon was a severe lymphoadenitis. The tumor calcium concentration showed an inverse relationship with the tumor growth rate. Carcinogenesis and lymphoadenitis are discussed considering well known effects of ferric and aluminum complexes with ATP on the cellular calcium homeostasis and of ATP on lymphatic tissue proliferation.
Anghileri
L J
LJ
Biophysics Laboratory, Faculty of Medicine, University of Nancy, France.
Plenat
F
F
Labouyrie
E
E
Thouvenot
P
P
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
D017607:Aluminum Compounds; D002273:Carcinogens; D005290:Ferric Compounds; D000255:Adenosine Triphosphate; C045858:ferric-adenosine triphosphate complex