[Antibiotic susceptibility of Neisseria gonorrhoeae isolates in Berlin].
OBJECTIVE
Because of the increasing resistance of Neisseria gonorrhoeae, we studied the actual resistance of isolates in Berlin.


METHODS
85 Neisseria gonorrhoeae isolates were collected between 1995 and 1997. Susceptibility testing was performed for penicillin G, tetracycline, spectinomycin, ceftriaxone, ciprofloxacin and azithromycin by agar dilution.


RESULTS
18.8% isolates were resistant or intermediately resistant to penicillin G (including 6 PPNG). 12.9% isolates were resistant, 43.5% intermediately resistant to tetracycline. One strain was resistant against ciprofloxacin, 4 isolates showed increased MIC values (0.06-0.5 mg/l), whereas 78 isolates were fully susceptible (< 0.007 mg/l). All isolates were susceptible to spectinomycin, ceftriaxone, and azithromycin.


CONCLUSIONS
Penicillin G and tetracycline should be given only in cases of proven sensibility. Resistance against ciprofloxacin may occur, especially in isolates acquired in south-east Asia. Ceftriaxone, spectinomycin and azithromycin were active against all isolates. The actual resistance situation should be monitored.
Wagner
J
J
Abteilung Medizinische Mikrobiologie und Infektionsimmunologie, Institut für Infektionsmedizin im Universitätsklinikum Benjamin Franklin (UKBF), FU Berlin.
Tebbe
B
B
Hörnle
R
R
Chahin
M
M
Arvand
M
M
Wendt
C
C
Orfanos
C E
CE
Hahn
H
H
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001604:Berlin; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*
D000900:Anti-Bacterial Agents