title: Positron-emission tomography with [18F]fluorodeoxyglucose. Part I. Biochemical uptake mechanism and its implication for clinical studies.
abstract: Over the past decades, Positron Emission Tomography has opened a new field of imaging. Nowadays, this technique is being used for diagnosing, staging disease as well as for prognostic stratification and monitoring therapy. In this respect, [18F]fluorodeoxyglucose (FdGlc) is by far the most commonly used PET agent. Many factors have been identified being responsible for a high uptake of this agent in malignancy. However, additional factors such as tumour treatment may interfere with the uptake mechanism. Knowledge of all these factors is a prerequisite for an optimal interpretation of PET studies and, consequently, for a reliable judgement of tumour status. In this article, a review is given of the factors influencing FdGlc uptake and the implications for clinical studies.
authors.affiliation: Leiden University Medical Centre, Division of Nuclear Medicine, The Netherlands. pauwels@mail.medfac.leidenuniv.nl
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
authors.forename: E J
authors.initials: EJ
authors.lastname: Sturm
authors.forename: E
authors.initials: E
authors.lastname: Bombardieri
authors.forename: F J
authors.initials: FJ
authors.lastname: Cleton
authors.forename: M P
authors.initials: MP
authors.lastname: Stokkel
mesh_terms: D002952:Citric Acid Cycle; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006019:Glycolysis; D006593:Hexokinase / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009004:Monosaccharide Transport Proteins / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D019275:Radiopharmaceuticals / Q000378:metabolism*; D014055:Tomography, Emission-Computed / Q000379:methods; D015854:Up-Regulation
chemical_list: D009004:Monosaccharide Transport Proteins; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D006593:Hexokinase