title: Comparing an additional hour of cycler therapy to an additional midday exchange to achieve adequacy targets.
abstract: As CAPD patients lose residual renal function, adequate dialysis is frequently impossible to obtain unless the dialysis prescription is changed. For patients already on cycler therapy with a "wet" day, we compared the advantage of adding one hour on the cycler to adding an extra, midday exchange. To compare the two approaches, we used a commercial computer program to optimize solute clearance in 90 patients. Adding one hour of cycler therapy increases Kt/V and creatinine clearance (CrCl) by approximately 6.4%-8%. When a midday exchange is added, the increase in Kt/V and CrCl varies between 17.5% and 21.6%. We conclude that adding an extra, midday exchange always gives a better increase in weekly Kt/V and CrCl than that obtained by adding an extra hour of cycler therapy.
authors.affiliation: Department of Medicine, University of Ottawa, Ontario, Canada.
authors.forename: D E
authors.initials: DE
authors.lastname: Pagé
mesh_terms: D003404:Creatinine / Q000378:metabolism; D006801:Humans; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D014508:Urea / Q000378:metabolism
chemical_list: D014508:Urea; D003404:Creatinine