title: [Primary neuroendocrine carcinoma of the bladder: diagnosis and treatment].
abstract: OBJECTIVE
  This rare but aggressive bladder tumour presents the morphological and immunohistochemical characteristic, common to all neuroendocrine tumours observed in other organs. This study analyzed the diagnostic criteria and therapeutic results obtained in 5 consecutive patients over a 3-year period.
  
  
  METHODS
  5 patients (3 men and 2 women) suffering from primary small cell carcinoma of the bladder were evaluated. Histological diagnosis, treatment modalities and outcome were reviewed.
  
  
  RESULTS
  The main clinical presentation was macroscopic haematuria. All tumours were invasive at the time of diagnosis. 4 patients were treated by trans urethral resection alone, 2 of whom also received adjuvant radio-chemotherapy. One patient was treated by radical cystectomy. The 4 patients treated by conservative treatment modality had progression and a shorter survival, in contrast with patient treated by radical cystectomy.
  
  
  CONCLUSIONS
  The urologist must recognize this rare histological entity, which have a poor prognosis and requires multidisciplinary management. Treatment must consist of a combination of neoadjuvant or adjuvant chemotherapy and surgery to achieve the best results.
authors.affiliation: Service d'Urologie, CHRU Pontchaillou, Rennes, France. karmtariq@yahoo.fr
authors.forename: T
authors.initials: T
authors.lastname: Karmouni
authors.forename: N
authors.initials: N
authors.lastname: Rioux-Leclercq
authors.forename: K
authors.initials: K
authors.lastname: Bensalah
authors.forename: A
authors.initials: A
authors.lastname: Alva
authors.forename: J J
authors.initials: JJ
authors.lastname: Patard
authors.forename: F
authors.initials: F
authors.lastname: Guillé
authors.forename: B
authors.initials: B
authors.lastname: Lobel
mesh_terms: D000328:Adult; D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy*