title: Predictors of postprandial triacylglycerol response in children: the Columbia University Biomarkers Study.
abstract: BACKGROUND
  Predictors of postprandial lipemia have not been explored in children.
  
  
  OBJECTIVE
  Our objective was to determine whether the postprandial triacylglycerol response is associated with low HDL-cholesterol and high fasting triacylglycerol concentrations and family history of early-onset ischemic heart disease (IHD) in children.
  
  
  METHODS
  We administered a standardized fat load (52.5 g fat/m(2)) to 60 children (mean age: 14.0 y), 20 with and 40 without a family history of early-onset IHD, and to 29 mothers, all recruited from families enrolled in the Columbia University Biomarkers Study. Plasma lipid and retinyl palmitate concentrations were measured in the fasting state and 3, 6, and 8 h after the oral fat load.
  
  
  RESULTS
  In children, postprandial lipemia, as indicated by the incremental area under the triacylglycerol response curve, was associated with elevated fasting triacylglycerol concentrations (>/=1.13 mmol/L; P: < 0.01), with low fasting HDL-cholesterol concentrations (</=0.91 mmol/L; P: < 0.01), and with the combination of low HDL-cholesterol and high triacylglycerol concentrations (P: < 0.05). Family history of IHD, baseline LDL-cholesterol concentration, and apolipoprotein E genotype were not associated with the postprandial triacylglycerol or retinyl palmitate response. The mothers had fasting triacylglycerol concentrations similar to those of their children but a more prolonged response with higher triacylglycerol concentrations at 6 and 8 h (P: < 0.01 and P: < 0.05, respectively).
  
  
  CONCLUSIONS
  In children, a delayed postprandial triacylglycerol response to a fat load is associated with the combination of high fasting triacylglycerol and low HDL-cholesterol concentrations. Predictors of postprandial triacylglycerol concentrations may be similar in children and adults.
authors.affiliation: Departments of Pediatrics and Medicine, Columbia University, New York, NY 10032, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Couch
authors.forename: C R
authors.initials: CR
authors.lastname: Isasi
authors.forename: W
authors.initials: W
authors.lastname: Karmally
authors.forename: W S
authors.initials: WS
authors.lastname: Blaner
authors.forename: T J
authors.initials: TJ
authors.lastname: Starc
authors.forename: D
authors.initials: D
authors.lastname: Kaluski
authors.forename: R J
authors.initials: RJ
authors.lastname: Deckelbaum
authors.forename: H N
authors.initials: HN
authors.lastname: Ginsberg
authors.forename: S
authors.initials: S
authors.lastname: Shea
authors.forename: L
authors.initials: L
authors.lastname: Berglund
mesh_terms: D000293:Adolescent; D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D004224:Diterpenes; D005215:Fasting; D005260:Female; D005502:Food; D005838:Genotype; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000235:genetics; D000084562:Retinyl Esters; D014280:Triglycerides / Q000097:blood*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D015415:Biomarkers; D008076:Cholesterol, HDL; D004041:Dietary Fats; D004224:Diterpenes; D000084562:Retinyl Esters; D014280:Triglycerides; D014801:Vitamin A; C014794:retinol palmitate