[Effects of neurohypophysial hormones and their synthetic analogs on platelet aggregation].
The effect of neurohypophysial hormones vasopressin and oxytocin as well as their synthetic analogs on platelet aggregation induced by thrombin or ADP was studied in vitro on washed rat platelets. Vasopressin and its analog DGAVP, as well as oxytocin enhanced thrombin-induced platelet aggregation, while their effect on ADP-induced aggregation was considerably lower. An oxytocin analog depotocin had a pronounced antithrombin effect indicated by a significant inhibition (by 81%) of thrombin-induced platelet aggregation and by assay for its antithrombin activity in the blood plasma.
Golubeva
M G
MG
Biological Faculty, Moscow State University, Russia.
Grigor'eva
M E
ME
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D066298:In Vitro Techniques; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D013917:Thrombin / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology* / Q000502:physiology
D014667:Vasopressins; D010121:Oxytocin; D000244:Adenosine Diphosphate; D013917:Thrombin