Synthesis of a peptidomimetic tricyclic tetrahydrobenzo[ij]quinoline as a VLA-4 antagonist.
Ho
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Roche Bioscience, Palo Alto, California 94304, USA. who@fibrogen.com
Broka
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D017607:Aluminum Compounds; D002448:Cell Adhesion; D006801:Humans; D007202:Indicators and Reagents; D039041:Integrin alpha4beta1; D016023:Integrins / Q000037:antagonists & inhibitors*; D019169:Jurkat Cells; D018020:Lithium Compounds; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D016201:Receptors, Lymphocyte Homing / Q000037:antagonists & inhibitors*
D017607:Aluminum Compounds; D007202:Indicators and Reagents; D039041:Integrin alpha4beta1; D016023:Integrins; D018020:Lithium Compounds; D011804:Quinolines; D016201:Receptors, Lymphocyte Homing; C042073:lithium aluminum hydride