The impact of haemofiltration on the systemic cardiovascular response.
Convective transport across the dialysis membrane has long been known to be a good alternative to diffusion. Among the advantages of haemofiltration over conventional haemodialysis is a better cardiovascular stability. Haemofiltration has a more physiological response to fluid removal than haemodialysis: (i) blood volume may be better preserved, especially in patients with a compromised cardiac function; (ii) arterial peripheral resistances and venous tone increase; and (iii) myocardial contractility is neither depressed nor altered. We discuss the role of the different pathophysiological mechanisms in the disparity in cardiovascular reactivity between haemofiltration and haemodialysis.
Santoro
A
A
Malpighi Division of Nephrology and Dialysis, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Mancini
E
E
Zucchelli
P
P
D001810:Blood Volume; D006439:Hemodynamics; D006440:Hemofiltration; D006801:Humans; D006435:Renal Dialysis; D014655:Vascular Resistance