[Use of radiotherapy in cardiovascular disease. Radiophysical basis, current results, indications and perspectives].
Restenosis is the main limitation of percutaneous angioplasty, especially in vessels of small diameters such as the coronary arteries, the femoro-popliteal and tibial-peroneal arteries and the arterio-venous dialysis grafts. The extensive use of tents has not entirely prevented its occurrence, whereas treating in-stent restenosis gives even more uncertain results. Endovascular radiotherapy has emerged over the past few years as a promising approach to both prevent and cure it. The analogy between the tumour-like cellular proliferations observed in post-angioplasty restenosis and tumour processes prompted pioneering works to study the effect of ionizing radiations in animal models of arterial restenosis. The demonstrated feasibility, tolerance and efficacy of this approach lead to test this strategy in humans. The results of 3 recently presented randomized double-blind trials in the treatment of coronary in-stent restenosis have been so promising that endovascular brachytherapy might now be considered the treatment of choice in this indication. Other randomized trials are currently carried out to test whether endovascular brachytherapy may prevent restenosis in coronary and femoro-popliteal arteries as well as in hemodialysis shunts. In the present review, we describe the basics of the biological effects of ionizing radiations, the technical modalities to deliver endovascular radiations, our current knowledge about their effects on the vascular wall and the restenosis mechanisms, and the results of the first clinical studies. Finally, we address the remaining problems in the use of endovascular curietherapy and question the promises and challenges of its clinical application.
Ledru
F
F
Département de cardiologie, hôpital européen Georges-Pompidou, Paris.
Giraud
P
P
Sapoval
M
M
Lafont
A
A
Gambini
D
D
Gaux
J C
JC
Guermonprez
J L
JL
Housset
M
M
D015906:Angioplasty, Balloon, Coronary; D001157:Arterial Occlusive Diseases / Q000532:radiotherapy / Q000628:therapy; D002318:Cardiovascular Diseases / Q000532:radiotherapy*; D003327:Coronary Disease / Q000532:radiotherapy* / Q000628:therapy; D006801:Humans; D012008:Recurrence