[A primary study of the association of human leucocyte antigen and osteosarcoma].
OBJECTIVE
To study the association of human leucocyte antigen and osteosarcoma in Chinese Han nationality.


METHODS
The frequencies of HLA-A,B,DR,DQ locus antigens were tested in a group of 25 osteosarcoma patients and in a control group of 250 healthy persons by using complement-dependent microlymphocytoxity technique. The members of both groups were of Chinese Han nationality. Their results were compared statistically.


RESULTS
The frequency of HLA-B35 was 0.400 in patient group and 0.048 in the control group. The relative risk of suffering from osteosarcoma in persons carrying HLA-B35 was 13.220 times as high as that in those without this antigen (P < 0.01). Patients with HLA-B13 had 12.048 fold increase in relative risk with poor prognosis compared to those without this antigen (P < 0.05). A tendency of worst prognosis was seen in patients who carried both HLA-B13 and HLA-B35, but patients with HLA-B40 had 7.057 times better relative safety for good prognosis than those without that antigen (P < 0.05).


CONCLUSIONS
HLA-B35 is in close linkage to osteosarcoma susceptible gene in Chinese Han nationality. HLA-B13 and HLA-B40 may be separately related to the malignant and resistant genes of osteosarcoma.
Zhang
W
W
Department of Orthopaedics, Rui Jin Hospital Affiliated Shanghai Second Medical University, Shanghai Institute of Orthopaedics and Traumatology.
Shen
C
C
Cai
T
T
D000293:Adolescent; D000328:Adult; D044466:Asian People; D001859:Bone Neoplasms / Q000235:genetics / Q000276:immunology*; D002681:China; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000032:analysis*; D059908:HLA-B13 Antigen; D015797:HLA-B35 Antigen / Q000032:analysis*; D059947:HLA-B40 Antigen; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000235:genetics / Q000276:immunology*; D011379:Prognosis
D015235:HLA-B Antigens; D059908:HLA-B13 Antigen; D015797:HLA-B35 Antigen; D059947:HLA-B40 Antigen