Myorelaxant and antispasmodic effects of the essential oil of Alpinia speciosa on rat ileum.
The effects of the essential oil of Alpinia speciosa Schum (EOAS) on rat ileum were studied. EOAS (0.1-600 microg/mL) reversibly relaxed ileal basal tonus. Submaximal contractions induced by 60 mM KCl or acetylcholine were concentration dependently inhibited by EOAS with similar IC(50) values ( approximately 44 and 48 microg/mL, respectively). These results show that EOAS possesses both relaxant and antispasmodic actions in the ileum.
Bezerra
M A
MA
Centro de Ciências da Saúde, Universidade Vale do Acaraú, 850 Avenida da Universidade, Campus da Betânia, CEP 62.040-370, Sobral, CE, Brazil.
Leal-Cardoso
J H
JH
Coelho-De-Souza
A N
AN
Criddle
D N
DN
Fonteles
M C
MC
D000818:Animals; D007082:Ileum / Q000187:drug effects*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009822:Oils, Volatile / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D019862:Zingiberales
D009822:Oils, Volatile; D010276:Parasympatholytics; D010938:Plant Oils