title: Genes involved in senescence and immortalization.
abstract: Senescence is now understood to be the final phenotypic state adopted by a cell in response to several distinct cell physiological processes, including proliferation, oncogene activation and oxygen free radical toxicity. The role of telomere maintenance in immortalization and the roles of p16(INK4A), p19(ARF), p53 and other genes in senescence are being further elucidated. Significant progress continues to be made in our understanding of cellular senescence and immortalization.
authors.affiliation: Whitehead Institute, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. Lundberg@wi.mit.edu
authors.forename: A S
authors.initials: AS
authors.lastname: Lundberg
authors.forename: W C
authors.initials: WC
authors.lastname: Hahn
authors.forename: P
authors.initials: P
authors.lastname: Gupta
authors.forename: R A
authors.initials: RA
authors.lastname: Weinberg
mesh_terms: D000818:Animals; D002455:Cell Division / Q000235:genetics; D016922:Cellular Senescence / Q000235:genetics*; D005786:Gene Expression Regulation; D019942:Genes, p16 / Q000235:genetics; D006801:Humans; D051379:Mice; D009857:Oncogenes / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics; D011506:Proteins / Q000235:genetics; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D016615:Telomere / Q000235:genetics / Q000378:metabolism; D025803:Tumor Suppressor Protein p14ARF
chemical_list: D011506:Proteins; D017382:Reactive Oxygen Species; D025803:Tumor Suppressor Protein p14ARF