DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers.
Markowitz
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Howard Hughes Medical Institute Laboratory, University Hospitals of Cleveland, Case Western Reserve University Cancer Center, Cleveland, OH, USA.
D020137:Base Pair Mismatch; D003110:Colonic Neoplasms / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans