[Antitumor activity of UFT and docetaxel on human breast carcinoma xenografts].
The effect of fluorinated pyrimidine co-administered with docetaxel on transplantable human breast cancer strains MX-1 and R-27 was investigated using an in vitro succinic dehydrogenase inhibition (SDI) method and an in vivo nude mouse transplant method. The in vivo results showed that the combined use of 5-fluorouracil and docetaxel enhanced antitumor activity. No antitumor activity on MX-1 was observed in vivo in either the UFT alone or docetaxel alone group, whereas co-administration of the two drugs resulted in a tumor inhibition rate of 85.1% above the effective line. These results suggest the usefulness of 5-fluorouracil in combination with docetaxel in the treatment of solid tumors.
Yamada
T
T
Biomedical Laboratory, Kitasato Institute Hospital.
Yamada
Y
Y
Asanuma
F
F
Kawamura
E
E
Suzuki
T
T
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000077143:Docetaxel; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors; D043823:Taxoids; D005641:Tegafur / Q000008:administration & dosage / Q000494:pharmacology; D014183:Transplantation, Heterologous; D014498:Uracil / Q000008:administration & dosage / Q000494:pharmacology; D023041:Xenograft Model Antitumor Assays
D043823:Taxoids; D005641:Tegafur; D000077143:Docetaxel; D014498:Uracil; D013385:Succinate Dehydrogenase; D017239:Paclitaxel