title: Vitamin E and prevention of heart disease in high-risk patients.
abstract: Several observational studies have suggested that high intake of vitamin E may slow the development and progression of atherosclerosis. Some clinical trials also reported beneficial effects of vitamin E supplementation in the secondary prevention of cardiovascular events. However, results of recent large, multicenter clinical trials reported that vitamin E supplementation was not effective in reducing the incidence of cardiovascular events in high-risk patients.
authors.affiliation: Vascular Biology Program, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
authors.forename: M
authors.initials: M
authors.lastname: Meydani
mesh_terms: D001161:Arteriosclerosis / Q000517:prevention & control; D019587:Dietary Supplements; D006331:Heart Diseases / Q000178:diet therapy / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D014810:Vitamin E / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D014810:Vitamin E