title: Evaluation of the ability of orally administered aspirin to mitigate effects of 3-methylindole in feedlot cattle.
abstract: OBJECTIVE
  To evaluate the ability of orally administered aspirin to mitigate 3-methylindole (3MI)-induced respiratory tract disease and reduced rate of gain in feedlot cattle.
  
  
  METHODS
  244 beef cattle.
  
  
  METHODS
  In a masked, randomized, controlled field trial, calves were untreated (controls) or received a single orally administered dose of aspirin (31.2 g) on entry into a feedlot. Serum 3MI concentrations were measured on days 0, 3, and 6. Rumen 3MI concentration was measured on day 3. Cattle were observed daily for clinical signs of respiratory tract disease. Lungs were evaluated at slaughter for gross pulmonary lesions.
  
  
  RESULTS
  Mean daily gain (MDG) in cattle treated with aspirin, compared with control cattle, was 0.06 kg greater in the backgrounding unit and 0.03 kg greater for the overall feeding period. Neither serum nor rumen 3MI concentrations appeared to modify this effect. Cattle treated with aspirin were more likely to be treated for respiratory tract disease. Mortality rate, gross pulmonary lesions, and serum and rumen 3MI concentrations were similar between groups. Increased rumen 3MI concentration was associated with a small difference in risk of lung fibrosis.
  
  
  CONCLUSIONS
  Cattle given a single orally administered dose of aspirin on feedlot entry had higher MDG in the backgrounding unit and for the overall feeding period, but this finding could not be attributed to mitigation of effects of 3MI. This may have been influenced by low peak 3MI production and slow rates of gain.
authors.affiliation: Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
authors.forename: H R
authors.initials: HR
authors.lastname: Bingham
authors.forename: T E
authors.initials: TE
authors.lastname: Wittum
authors.forename: P S
authors.initials: PS
authors.lastname: Morley
authors.forename: T M
authors.initials: TM
authors.lastname: Bray
authors.forename: C F
authors.initials: CF
authors.lastname: Sarver
authors.forename: W G
authors.initials: WG
authors.lastname: Queen
authors.forename: W P
authors.initials: WP
authors.lastname: Shulaw
mesh_terms: D000284:Administration, Oral; D000822:Animal Husbandry / Q000379:methods*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced / Q000517:prevention & control*; D012862:Skatole; D015430:Weight Gain / Q000187:drug effects
chemical_list: D012862:Skatole; D001241:Aspirin