Vertebrate segmentation: is cycling the rule?
Vertebrate segmentation initiates with the subdivision of the paraxial mesoderm into a regular array of somites. Recent evidence suggests that the segmentation clock - a biochemical oscillator acting in the unsegmented paraxial mesoderm cells in most vertebrates - controls cyclic Notch signalling, resulting in periodic formation of somite boundaries.
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Laboratoire de génétique et de physiologie du développement (LGPD). Developmental Biology Institute of Marseille (IBDM). CNRS-INSERM-Université de la méditerranée-AP de Marseille, Campus de Luminy, Marseille, France.
D000818:Animals; D001001:Anura; D001683:Biological Clocks / Q000502:physiology; D019521:Body Patterning / Q000502:physiology*; D002642:Chick Embryo; D008565:Membrane Proteins / Q000378:metabolism; D008648:Mesoderm / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D011506:Proteins / Q000378:metabolism; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology; D019170:Somites / Q000166:cytology* / Q000378:metabolism; D020825:T-Box Domain Proteins / Q000378:metabolism; D051153:Wnt Proteins; D060508:Wnt3 Protein; D015027:Zebrafish
D008565:Membrane Proteins; D011506:Proteins; D051880:Receptors, Notch; D020825:T-Box Domain Proteins; D051153:Wnt Proteins; D060508:Wnt3 Protein