title: Induction of labor by prostaglandin E(2) in relation to the Bishop score.
abstract: OBJECTIVE
  To compare the effectiveness of prostaglandin E(2) intravaginal gel with the intracervical gel in patients with an unfavorable cervix.
  
  
  METHODS
  In a prospective multicenter trial 470 patients with unfavorable Bishop scores (3-4) were randomized to receive prostaglandin vaginal gel (2 mg) or intracervical gel (0.5 mg).
  
  
  RESULTS
  In patients with unfavorable Bishop scores the intravaginal application route resulted in a better cervical ripening, a shorter induction to delivery interval and a higher cumulative rate of deliveries during 24 h (P=0.01).
  
  
  CONCLUSIONS
  Intravaginal instillation of prostaglandin E(2) gel for induction of labor is effective in patients with an unfavorable Bishop score of 3-4.
authors.affiliation: Department of Obstetrics and Gynecology, Technical University Hospital of Aachen, Aachen, Germany. birgit.kemp@post.rwth-aachen.de
authors.forename: B
authors.initials: B
authors.lastname: Kemp
authors.forename: M
authors.initials: M
authors.lastname: Winkler
authors.forename: W
authors.initials: W
authors.lastname: Rath
mesh_terms: D000282:Administration, Intravaginal; D020070:Cervical Ripening / Q000187:drug effects*; D002584:Cervix Uteri / Q000033:anatomy & histology / Q000187:drug effects*; D015232:Dinoprostone / Q000008:administration & dosage* / Q000191:economics; D005260:Female; D005782:Gels; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010120:Oxytocics / Q000008:administration & dosage* / Q000191:economics; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D005782:Gels; D010120:Oxytocics; D015232:Dinoprostone