Effects of environmental pollutants on airways, allergic inflammation, and the immune response.
Particulate and gaseous air pollutants are capable of damaging the airway epithelial lining and of shifting the local immune balance, thereby facilitating the induction of persistent inflammation. Epidemiological studies are inconclusive regarding whether air pollution increases the incidence of asthma and chronic bronchitis in the population. Clearly, environmental pollution can, however, precipitate attacks and emergency-room admissions in those already suffering from such conditions. The catastrophic potential of airborne pollution was demonstrated in the 1960s and 1970s, when inverted atmospheric pressure conditions trapped smog over cities on the Eastern coast of the United States and over Europe. This smog resulted in thousands of hospital admissions and dozens of deaths. With the general rise in the incidence of atopy and asthma in the Western population, it is of major public health interest to reduce, as much as possible, the exposure of such populations to anthropogenic and natural sources of pollution.
Handzel
Z T
ZT
Clinical Immunology and Allergy Unit, Kaplan Medical Center, Rehovot, Israel. handzel@agri.huji.ac.il
D000171:Acrolein / Q000009:adverse effects; D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D016207:Cytokines / Q000502:physiology; D005557:Formaldehyde / Q000009:adverse effects; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000009:adverse effects; D007249:Inflammation / Q000276:immunology; D009589:Nitrogen Oxides / Q000009:adverse effects; D010126:Ozone / Q000009:adverse effects; D010586:Phagocytes / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000139:chemically induced* / Q000276:immunology*; D012905:Smog / Q000009:adverse effects; D012907:Smoking / Q000009:adverse effects; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
D000393:Air Pollutants; D000485:Allergens; D016207:Cytokines; D006841:Hydrocarbons, Aromatic; D009589:Nitrogen Oxides; D012905:Smog; D014028:Tobacco Smoke Pollution; D005557:Formaldehyde; D010126:Ozone; D000171:Acrolein