title: Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic.
abstract: In India, 320 patients with visceral leishmaniasis (209 in the state of Bihar and 11 in the neighboring state of Uttar Pradesh) received identical pentavalent antimony (Sb) treatment. Sb induced long-term cure in 35% (95% confidence interval [CI], 28%-42%) of those in Bihar versus 86% (95% CI, 79%-93%) of those in Uttar Pradesh. In Bihar, the center of the Indian epidemic, traditional Sb treatment should be abandoned.
authors.affiliation: The Kala-Azar Medical Research Center, Banaras Hindu University Institute of Medical Sciences, Varanasi, India. shyams@nde.vsnl.net.in
authors.forename: S
authors.initials: S
authors.lastname: Sundar
authors.forename: D K
authors.initials: DK
authors.lastname: More
authors.forename: M K
authors.initials: MK
authors.lastname: Singh
authors.forename: V P
authors.initials: VP
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: A
authors.initials: A
authors.lastname: Makharia
authors.forename: P C
authors.initials: PC
authors.lastname: Kumar
authors.forename: H W
authors.initials: HW
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D000981:Antiprotozoal Agents; D000967:Antimony Sodium Gluconate