title: Aging mechanisms.
abstract: Aging (senescence) has long been a difficult issue to be experimentally analyzed because of stochastic processes, which contrast with the programmed events during early development. However, we have recently started to learn the molecular mechanisms that control aging. Studies of the mutant mouse, klotho, showing premature aging, raise a possibility that mammals have an "anti-aging hormone." A decrease of cell proliferation ability caused by the telomeres is also tightly linked to senescence. Frontier experimental studies of aging at the molecular level are leading to fascinating hypotheses that aging is the price we had to pay for the evolution of the sexual reproduction system that produces a variety of genetic information and complex body structures.
authors.affiliation: Nara Institute of Science and Technology, Department of Biological Science, 8916-5, Takayama, Ikoma, Nara 630-0101, Japan. yotayota@bs.aist-nara.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Kuro-O
authors.forename: F
authors.initials: F
authors.lastname: Ishikawa
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D002455:Cell Division; D005818:Genetic Engineering; D005966:Glucuronidase; D006801:Humans; D000090265:Klotho Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains; D023421:Models, Animal; D012098:Reproduction / Q000502:physiology*; D016615:Telomere / Q000502:physiology*
chemical_list: D008565:Membrane Proteins; D005966:Glucuronidase; D000090265:Klotho Proteins