Latency-associated peptide of transforming growth factor beta enhances mycobacteriocidal immunity in the lung during Mycobacterium bovis BCG infection in C57BL/6 mice.
Latency-associated peptide of transforming growth factor beta (TGF-beta) (LAP) was used to determine whether in vivo modulation of TGF-beta bioactivity enhanced pulmonary immunity to Mycobacterium bovis BCG infection in C57BL/6 mice. LAP decreased BCG growth in the lung and enhanced antigen-specific T-cell proliferation and gamma interferon mRNA expression. Thus, susceptibility of the lung to primary BCG infection may be partially mediated by the immunosuppressive effects of TGF-beta.
Wilkinson
K A
KA
Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106-4984, USA.
Martin
T D
TD
Reba
S M
SM
Aung
H
H
Redline
R W
RW
Boom
W H
WH
Toossi
Z
Z
Fulton
S A
SA
D000818:Animals; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D008168:Lung / Q000276:immunology* / Q000382:microbiology*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D009163:Mycobacterium bovis / Q000276:immunology*; D012333:RNA, Messenger / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000502:physiology*; D014376:Tuberculosis / Q000276:immunology*
D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D007371:Interferon-gamma