[Direct protection of injured primary cultured hepatocytes of rats treated with carbon tetrachloride by salvianic acid B].
The incorporation of [3H]thymidine obviously tends to decrease in the primary cultured hepatocytes of rats when the cells are treated with carbon tetrachloride. Meanwhile the activity of ALT markedly increases in the medium. But these pathologic alterations are inhibited by Salvianic acid B(SA-B) and the effect of 10(-6) mol/L SA-B is the best.
Liu
P
P
Liver Diseases Research Center of Shanghai Acadamy of Traditional Chinese Med icine.
Liu
N
N
Xu
L
L
Hu
Y
Y
Ji
G
G
Liu
C
C
D000410:Alanine Transaminase / Q000378:metabolism*; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D002251:Carbon Tetrachloride; D002478:Cells, Cultured; D008099:Liver / Q000166:cytology* / Q000201:enzymology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D053630:Depsides
D000410:Alanine Transaminase; D001572:Benzofurans; D002251:Carbon Tetrachloride; C076944:salvianolic acid B; D053630:Depsides