Rifampicin polylactic acid microspheres for lung targeting.
Rifampicin polylactic acid microspheres for lung targeting were prepared by a modified emulsion-solvent diffusion method. The microspheres were free flowing, spherical with regular surface. Drug content, particle size distribution and in vitro release properties of the prepared microspheres were evaluated. In vivo experiments on rabbits showed remarkable accumulation of microspheres in the lung.
Zhang
W
W
Department of Pharmacy, Changhai Hospital, Shanghai, China.
Jiang
X
X
Hu
J
J
Fu
C
C
D000818:Animals; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002214:Capsules; D004339:Drug Compounding / Q000379:methods; D004655:Emulsions; D006801:Humans; D066298:In Vitro Techniques; D019344:Lactic Acid; D008168:Lung / Q000187:drug effects* / Q000378:metabolism*; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters; D011108:Polymers; D011817:Rabbits; D012293:Rifampin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D012997:Solvents; D014018:Tissue Distribution
D000904:Antibiotics, Antitubercular; D002214:Capsules; D004655:Emulsions; D011091:Polyesters; D011108:Polymers; D012997:Solvents; D019344:Lactic Acid; C033616:poly(lactide); D012293:Rifampin