title: Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle.
abstract: Cyclin-dependent kinases are the key regulators of cell-cycle transitions. In mammalian cells, Cdk2, Cdk4, Cdk6 and associated cyclins control the G(1) to S phase transition. Because proper regulation of this transition is critical for an organism's survival, these protein kinases are exquisitely regulated at different mechanistic levels and in response to a large variety of intrinsic and extrinsic signals.
authors.affiliation: Department of Oncology/Pathology, Cancer Center Karolinska, Karolinska Insitutet, 17176, Stockholm, Sweden.
authors.forename: S V
authors.initials: SV
authors.lastname: Ekholm
authors.forename: S I
authors.initials: SI
authors.lastname: Reed
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D056746:Cyclin G; D056766:Cyclin G1; D050759:Cyclin-Dependent Kinase Inhibitor p21; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D016213:Cyclins / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000378:metabolism; D051379:Mice; D010447:Peptide Hydrolases / Q000378:metabolism; D010766:Phosphorylation; D017510:Protein Folding
chemical_list: C534703:Ccng1 protein, mouse; C493957:Cdkn1a protein, mouse; D056746:Cyclin G; D056766:Cyclin G1; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D004791:Enzyme Inhibitors; D018844:Cyclin-Dependent Kinases; D010447:Peptide Hydrolases