Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains.
The postantibiotic leukocyte enhancement (PALE) of meropenem in vitro in comparison with that of imipenem was evaluated with 24 recently isolated gram-positive and gram-negative strains. In general, pre-exposure to carbapenems (at four times the MIC for 2 h) led to increased polymorphonuclear cell phagocytic killing. The PALE of imipenem was generally significantly less than that observed with meropenem.
Novelli
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Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze, Florence, Italy. novelli@server1.pharm.unifi.it
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000502:physiology; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D007962:Leukocytes / Q000502:physiology*; D000077731:Meropenem; D009504:Neutrophils / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem