title: Tibial hemimelia, meningocele, and abdominal hernia in Shorthorn cattle.
abstract: Six genetically related Shorthorn calves were affected with the tibial hemimelia syndrome. The lesions included bilaterally malformed or absent tibia and abdominal hernia in all animals, a long shaggy haircoat, retained testicles in males, and meningocele in three animals. The malformations were similar to those described previously in Galloway calves. Pedigree analysis demonstrated a mechanism by which a recessive allele in a homozygous state could be responsible for the disorder. The condition in these calves was considered the result of a recurrence of a genetic mutation affecting a putative hemimelia locus.
authors.affiliation: Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyancinthe, PQ, Canada. lapoije@medvet.umontreal.ca
authors.forename: J M
authors.initials: JM
authors.lastname: Lapointe
authors.forename: S
authors.initials: S
authors.lastname: Lachance
authors.forename: D J
authors.initials: DJ
authors.lastname: Steffen
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics / Q000473:pathology*; D004480:Ectromelia / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006555:Hernia, Ventral / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008588:Meningocele / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D010375:Pedigree; D013977:Tibia / Q000473:pathology*