Cytogenetic and fluorescence in situ hybridization studies in four cases of plasma cell leukemia.
We present a cytogenetic and fluorescence in situ hybridization (FISH) study, using centromeric probes for chromosomes 3, 7, 11, and 18, TP53 gene (17p13), and RB-1 locus (13q14) DNA probes, in four cases of plasma cell leukemia (PCL). Among the four cases, three presented monosomy of the RB-1 locus and one monoallelic deletion of the TP53 gene. The present report shows the usefulness of the FISH technique to detect abnormalities not previously observed by conventional cytogenetics.
Lloveras
E
E
Laboratori de Citologia Hematològica/Laboratori de Referència de Catalunya, Unitat d'Hematologia, Hospital del Mar, Barcelona, Spain.
Solé
F
F
Espinet
B
B
Besses
C
C
Asensio
A
A
Abella
E
E
Woessner
S
S
Florensa
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015342:DNA Probes; D004276:DNA, Satellite; D005260:Female; D016161:Genes, Retinoblastoma; D016158:Genes, p53; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007952:Leukemia, Plasma Cell / Q000235:genetics*; D008297:Male
D015342:DNA Probes; D004276:DNA, Satellite