title: Fatal thrombotic thrombocytopenic purpura as a rare complication following allogeneic stem cell transplantation.
abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare disease which, together with hemolytic uremic syndrome, is subsumed under thrombotic microangiopathy. After stem cell transplantation (SCT), this syndrome represents a possibly fatal complication with a higher incidence in allogeneic SCT than in autologous SCT. Although plasmapheresis offers an encouraging treatment modality in classic TTP, this seems less effective in bone marrow transplant-associated microangiopathy. This is probably due to a different etiology. We present a case of transplant-associated TTP with a fatal outcome despite multiple courses of plasmapheresis.
authors.affiliation: I. Department of Medicine, University of Cologne, Köln, Germany. jens.chemnitz@uni-koeln.de
authors.forename: J
authors.initials: J
authors.lastname: Chemnitz
authors.forename: M
authors.initials: M
authors.lastname: Fuchs
authors.forename: W
authors.initials: W
authors.lastname: Blau
authors.forename: P
authors.initials: P
authors.lastname: Hartmann
authors.forename: C
authors.initials: C
authors.lastname: Wickenhauser
authors.forename: C
authors.initials: C
authors.lastname: Scheid
authors.forename: A
authors.initials: A
authors.lastname: Schulz
authors.forename: V
authors.initials: V
authors.lastname: Diehl
authors.forename: D
authors.initials: D
authors.lastname: Söhngen
mesh_terms: D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology* / Q000628:therapy; D014184:Transplantation, Homologous