Giant cell myocarditis as a manifestation of drug hypersensitivity.
Adverse drug effects on the myocardium are often classified into toxic and hypersensitivity forms of myocarditis, each with distinct histologic findings. In contrast, giant cell myocarditis (GCM) is generally not associated with adverse drug reactions and has unique histopathologic features. We report four cases of adverse drug reactions in which the histologic findings were characteristic of GCM. The clinical recognition that GCM may be a manifestation of an adverse drug reaction is important, since the prognosis and treatment of this entity may be different from that of other forms of myocarditis.
Daniels
P R
PR
Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Berry
G J
GJ
Tazelaar
H D
HD
Cooper
L T
LT
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects; D001262:Atenolol / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006101:Granuloma, Giant Cell / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects; D009205:Myocarditis / Q000139:chemically induced* / Q000473:pathology; D009206:Myocardium / Q000473:pathology*
D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D000959:Antihypertensive Agents; D001262:Atenolol; D008911:Minocycline