High prevalence of GB virus C/hepatitis G virus RNA and antibodies in patients infected with human immunodeficiency virus type 1.
The prevalence of GB virus C (GBV-C)/ hepatitis G virus (HGV) RNA and antibodies to the structural E2 protein was investigated in a cohort of HIV-1 infected patients. Of 346 individuals, RNA was detected in 143 and E2 antibodies were detected in 73, for an overall prevalence of 62.4%. Intravenous drug use and homosexuality were identified as major transmission risk factors. GBV-C/HGV RNA prevalence was associated with hepatitis B coinfection, whereas antibodies to E2 were associated with older age and lower CD4+ cell counts. GBV-C/HGV infection was frequent in this group of HIV-infected patients and was associated with older age, lower CD4 + cell counts, and the presence of hepatitis B surface antigen.
Rey
D
D
CISIH, Clinique Médicale A. Hôpitaux Universitaires, Strasbourg, France. david.rey@chru-strasbourg.fr
Vidinic-Moularde
J
J
Meyer
P
P
Schmitt
C
C
Fritsch
S
S
Lang
J M
JM
Stoll-Keller
F
F
D017502:Adenovirus E2 Proteins / Q000276:immunology; D000328:Adult; D005260:Female; D018067:Flaviviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D015658:HIV Infections / Q000150:complications*; D006508:Hepatitis Antibodies / Q000097:blood* / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood*
D017502:Adenovirus E2 Proteins; D006508:Hepatitis Antibodies; D012367:RNA, Viral