Studies on the resuscitative efficacy of polymerized bovine hemoglobin.
The paper described modified hemoglobin (Hb) with glycolaldehyde for the efficacy on resuscitation of severe hemorrhagic shock. Our objective was to compare the effect on resuscitation of severe hemorrhagic shock with different experimental groups. Results showed early resuscitation with modified bovine Hb is superior to lactated Ringer's solution group in improving hemodynamic and acidosis, but the effect of polymerized Hb with glycolaldehyde were similar to fresh whole blood in this rat model.
Bu
F
F
Institute of Transfusion Medicine, Beijing, P.R. China.
Wang
H
H
Zhu
X
X
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000494:pharmacology; D000471:Alkalosis / Q000517:prevention & control; D000818:Animals; D001704:Biopolymers; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes / Q000627:therapeutic use*; D001803:Blood Transfusion; D001831:Body Temperature / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002417:Cattle; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005440:Fluid Therapy; D006339:Heart Rate / Q000187:drug effects; D006454:Hemoglobins / Q000737:chemistry / Q000187:drug effects / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D007552:Isotonic Solutions / Q000627:therapeutic use; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D051381:Rats; D017208:Rats, Wistar; D012151:Resuscitation / Q000379:methods*; D000077325:Ringer's Lactate; D012771:Shock, Hemorrhagic / Q000628:therapy*
D001704:Biopolymers; D001802:Blood Substitutes; D003432:Cross-Linking Reagents; D006454:Hemoglobins; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D002245:Carbon Dioxide; D000079:Acetaldehyde; D010100:Oxygen; C010972:glycolaldehyde