title: Gene aberrations in childhood brain tumors.
abstract: We present the results of the examination of prognostic markers in 40 children suffering from brain tumors. Prognostic markers such as amplification of the N-myc and c-myc, deletion of the 17p, and DNA ploidy are indispensable factors for the determination of diagnosis. An increased number of c-myc gene copies was found in malignant brain tumors, especially embryonal, more often than reported in the literature. N-myc amplification occurs in our group seldom, but it seems to be a sign of worse prognosis in glial and embryonal brain tumors. DNA aneuploidy was not found very frequently, but in high-grade tumors only.
authors.affiliation: Department of Pediatric Oncology, University Hospital Motol, Prague, Czech Republic.
authors.forename: H
authors.initials: H
authors.lastname: Kucerová
authors.forename: E
authors.initials: E
authors.lastname: Stejskalová
authors.forename: A
authors.initials: A
authors.lastname: Vícha
authors.forename: M
authors.initials: M
authors.lastname: Tichý
authors.forename: M
authors.initials: M
authors.lastname: Chánová
authors.forename: D
authors.initials: D
authors.lastname: Sumerauer
authors.forename: J
authors.initials: J
authors.lastname: Koutechký
authors.forename: T
authors.initials: T
authors.lastname: Eckschlager
mesh_terms: D000293:Adolescent; D000782:Aneuploidy; D001932:Brain Neoplasms / Q000145:classification / Q000235:genetics*; D002528:Cerebellar Neoplasms / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005784:Gene Amplification; D020440:Gene Duplication; D016259:Genes, myc; D005910:Glioma / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000235:genetics; D018242:Neuroectodermal Tumors, Primitive / Q000235:genetics; D011003:Ploidies