The effects of soybean transphosphatidylated phosphatidylserine on cholinergic synaptic functions of mice.
The effects of soybean transphosphatidylated phosphatidylserine (SB-tPS) on cholinergic synaptic functions were investigated using cerebral cortical synaptosomes from mice. Treatment of the synaptosomes with SB-tPS increased high K+-induced acetylcholine (ACh) release in a bell-shaped, dose-dependent manner without affecting ACh synthesis. SB-tPS (10 and 50microM) also enhanced synaptosomal synthesis of sn-glycero-3-phosphocholine, but did not affect phosphorylcholine synthesis. In contrast, the choline synthesis was significantly reduced as SB-tPS concentration increased. The present result that SB-tPS modified the cholinergic pathway can partly explain its nootropic functions.
Yamatoya
H
H
Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan.
Sakai
M
M
Kudo
S
S
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005997:Glycerylphosphorylcholine / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018697:Nootropic Agents / Q000494:pharmacology*; D010718:Phosphatidylserines / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000378:metabolism; D013025:Glycine max / Q000737:chemistry*; D013569:Synapses / Q000187:drug effects* / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
D018697:Nootropic Agents; D010718:Phosphatidylserines; D011950:Receptors, Cholinergic; D005997:Glycerylphosphorylcholine; D000109:Acetylcholine