Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands.
Solution- and solid-phase methods for the preparation of peptide-substituted thiazolidinediones have been developed as an approach towards the preparation of a library of these compounds as potential ligands for the peroxisome proliferator-activated receptors (PPARs).
Mohler
D L
DL
Department of Chemistry, Emory University, Atlanta, GA 30322, USA. dmohler@emory.edu
Shen
G
G
Dotse
A K
AK
D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008024:Ligands; D009687:Nuclear Proteins / Q000378:metabolism; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014157:Transcription Factors / Q000378:metabolism*
D004151:Dipeptides; D007202:Indicators and Reagents; D008024:Ligands; D009687:Nuclear Proteins; D019151:Peptide Library; D010455:Peptides; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D014157:Transcription Factors