title: Hemolytic uremic syndrome in a child with leukemia and cytomegalovirus infection.
abstract: A 2-year-old boy had a severe cytomegalovirus (CMV) infection with multi-organ involvement, while on maintenance therapy for acute lymphoblastic leukemia. The patient was treated with intravenous gancyclovir, with a marked improvement in his clinical status, with the exception of a progressive deterioration of the renal function. He also developed hemolytic anemia and thrombocytopenia, suggesting a diagnosis of atypical hemolytic uremic syndrome (HUS). A percutaneous renal biopsy showed lesions consistent with HUS, but no evidence of CMV infection. The patient had a good clinical outcome with no evidence of renal sequelae. We report a rare association of CMV infection and HUS in the pediatric age-group, which suggests a possible cause-effect relationship that deserves further evaluation.
authors.affiliation: Department of Pediatrics, Catholic University School of Medicine, Santiago, Chile. feavagna@med.puc.cl
authors.forename: F
authors.initials: F
authors.lastname: Cavagnaro
authors.forename: F
authors.initials: F
authors.lastname: Barriga
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D015774:Ganciclovir / Q000627:therapeutic use; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir