title: Evaluation of outcome and QOL in patients with craniofacial resection for malignant tumors involving the anterior skull base.
abstract: The purpose of this study was to retrospectively evaluate the effectiveness of anterior craniofacial resection in the treatment of nasal and paranasal malignant tumors involving anterior skull base. Between 1992 and 1998, 13 patients with nasal or paranasal malignant tumors underwent this surgical procedure. The site and time of metastasis or recurrence, and survival outcome were retrospectively surveyed. Current status of long-surviving patients and their subjective assessment of the surgical treatment were also evaluated through questionnaires. Median follow-up period was 52 months. Nine patients (69%) were alive with no evidence of disease. Of these patients, eight had survived for more than three years. Recurrence or metastasis occurred in four patients (31%). The mean time interval between surgery and recurrence or metastasis was 11 months. According to the results of questionnaires to long-surviving patients, 89% patients had some complaints. In particular, complaints of unsightly appearance were manifested by all these patients. When the patients themselves evaluated their current conditions resulting from this surgical treatment, 63% were dissatisfied. These results suggest that this surgical treatment is valid for selected patients in regard to survival outcome. When the effectiveness of this treatment is evaluated, however, psychological and functional issues should not be taken lightly.
authors.affiliation: Department of Neurological Surgery, Chiba University, School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fukuda
authors.forename: N
authors.initials: N
authors.lastname: Saeki
authors.forename: S
authors.initials: S
authors.lastname: Mine
authors.forename: M
authors.initials: M
authors.lastname: Oga
authors.forename: A
authors.initials: A
authors.lastname: Yamaura
authors.forename: J
authors.initials: J
authors.lastname: Yuza
authors.forename: H
authors.initials: H
authors.lastname: Nagata
authors.forename: T
authors.initials: T
authors.lastname: Numata
authors.forename: Y
authors.initials: Y
authors.lastname: Konno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005147:Facial Bones / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000473:pathology / Q000601:surgery; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology; D011788:Quality of Life; D012189:Retrospective Studies; D012886:Skull / Q000601:surgery; D019292:Skull Base Neoplasms / Q000401:mortality / Q000523:psychology / Q000556:secondary* / Q000601:surgery*; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome