title: A study on the promotion and suppression of demineralization of human dental hard tissues and hydroxyapatite.
abstract: Demineralization of human dental enamel and dentine and their analogue compound, hydroxyapatite, was examined by using pH-metry to measure the time-courses of neutralization of acetate, formate, lactate or propionate buffer solution or of acidification of EDTA solution. The extent of neutralization by enamel, dentine and hydroxyapatite was different for each acid but increased in the same order: propionate, acetate, lactate and formate. This order was consistent with that of the K values of these acids. The pH-metry was used to determine the influences of sodium chloride and sucrose on demineralization of enamel, dentine and hydroxyapatite by acetate, formate, lactate and propionate and by EDTA. The demineralization by these bioorganic acids was suppressed by sucrose but promoted by sodium chloride, except that the demineralization of enamel by acetate and propionate was little affected. The demineralization of enamel, dentine and hydroxyapatite by EDTA was little affected by sucrose but promoted by sodium chloride. The promotive effect of sodium chloride on demineralization may be due to the increasing of solubility product by this salt and the suppressive effect of sucrose may be due to the formation of a calcium saccharate formed from the sucrose reacted with calcium on the surface of apatite crystal and/or the reduction of solubility product by the sucrose. In this study, it was also ascertained that the use of pH-metry made it possible to determine easily the demineralization.
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Odajima
authors.forename: M
authors.initials: M
authors.lastname: Onishi
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D003743:Dental Enamel / Q000737:chemistry*; D003804:Dentin / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D004492:Edetic Acid / Q000737:chemistry; D005561:Formates / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000737:chemistry; D011422:Propionates / Q000737:chemistry
chemical_list: D005561:Formates; D011422:Propionates; C030544:formic acid; D019344:Lactic Acid; D017886:Durapatite; D004492:Edetic Acid; C029658:propionic acid; D019342:Acetic Acid