Isolated pericardial effusion and transient abnormal myelopoiesis in a fetus with Down's syndrome.
Isolated pericardial effusion was detected in a fetus at 34 weeks of gestation. A male infant weighing 2,044 g was born by cesarean section because of a non-assuring fetal heart rate pattern at 35 weeks of gestation. Transient leukocytosis (36,100/microl) with 49% blast cells was seen in this neonate. The infant's karyotype was 47, XY + 21. The pericardial effusion disappeared after treatment with prednisolone at a dose of 2 mg/kg/day. Hypothyroidism was subsequently found. Thus, the subject patient with Down's syndrome developed isolated pericardial effusion, transient abnormal myelopoiesis (TAM), and hypothyroidism. Because more than 20% of the infants with TAM and Down's syndrome develop acute nonlymphocytic leukemia in early childhood, he is being closely observed.
Hirashima
C
C
Center for Perinatal Medicine, Jichi Medical School Hospital, Tochigi, Japan.
Eguchi
Y
Y
Kohmura
Y
Y
Minakami
H
H
Sato
I
I
D000328:Adult; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000150:complications / Q000175:diagnosis* / Q000196:embryology; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000196:embryology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000175:diagnosis; D007231:Infant, Newborn; D019891:Leukopoiesis; D008297:Male; D010490:Pericardial Effusion / Q000150:complications* / Q000000981:diagnostic imaging / Q000196:embryology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography