title: Chemical analyses of Ukrain, a semi-synthetic Chelidonium majus alkaloid derivative, fail to confirm its trimeric structure.
abstract: Ukrain has been described as a semi-synthetic Chelidonium majus alkaloid derivative, consisting of three chelidonine alkaloids combined to triaziridide. We found the actions of Ukrain to be similar to the Chelidonium alkaloids it is prepared from, and therefore became concerned about its chemical integrity. Chemical analyses of Ukrain by thin layer chromatography, high-performance liquid chromatography and liquid chromatography-mass spectrometry was inconsistent with the proposed trimeric structure and demonstrated that at least some commercial preparations of Ukrain consist of a mixture of C. majus alkaloids (including chelidonine).
authors.affiliation: Department of Physiology, University of Pretoria, P.O. Box 2034, 0001, Pretoria, South Africa.
authors.forename: A
authors.initials: A
authors.lastname: Panzer
authors.forename: A M
authors.initials: AM
authors.lastname: Joubert
authors.forename: J N
authors.initials: JN
authors.lastname: Eloff
authors.forename: C F
authors.initials: CF
authors.lastname: Albrecht
authors.forename: E
authors.initials: E
authors.lastname: Erasmus
authors.forename: J C
authors.initials: JC
authors.lastname: Seegers
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D001600:Berberine Alkaloids; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D013058:Mass Spectrometry; D010207:Papaver / Q000737:chemistry; D010617:Phenanthridines; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D011208:Powders
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D001600:Berberine Alkaloids; D010617:Phenanthridines; D010936:Plant Extracts; D011208:Powders; C060921:ukrain