The mechanism of phospholipase C-gamma1 regulation.
Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while DAG directly activates protein kinase C. Upon stimulation of cells with growth factors, PLC-gamma1 is activated upon their association with and phosphorylation by receptor and non-receptor tyrosine kinases. In this review, we will focus on the activation mechanism and regulatory function of PLC-gamma1.
Kim
M J
MJ
Department of Life Science, Pohang University of Science and Technology, Kyungbuk, Korea.
Kim
E
E
Ryu
S H
SH
Suh
P G
PG
D002455:Cell Division; D004789:Enzyme Activation; D007527:Isoenzymes / Q000378:metabolism*; D051966:Phospholipase C gamma; D015290:Second Messenger Systems; D013601:T-Lymphocytes; D010738:Type C Phospholipases / Q000378:metabolism*
D007527:Isoenzymes; D010738:Type C Phospholipases; D051966:Phospholipase C gamma