title: Protegrins: new antibiotics of mammalian origin.
abstract: Protegrins and their derivatives are a new class of peptide antibiotics based on mammalian antimicrobial peptides. Their pharmacological properties include an unusually broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi and some enveloped viruses. Preclinical and clinical studies of the lead compound, IB-367, developed for topical applications, show promise for the prevention of chemotherapy- and radiation-induced oral mucositis.
authors.affiliation: CHS 37-055, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA.
authors.forename: L
authors.initials: L
authors.lastname: Bellm
authors.forename: R I
authors.initials: RI
authors.lastname: Lehrer
authors.forename: T
authors.initials: T
authors.lastname: Ganz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008322:Mammals / Q000378:metabolism*; D010455:Peptides
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides