Energy-dependent UV light-induced disruption of (-)sulpiride antagonism of dopamine.
The dopamine D2 receptor antagonist sulpiride decreases the spontaneous locomotor activity of Planaria in an enantiomeric-selective and dose-dependent manner. We now report that (-)sulpiride (0.1 microM)-induced decrease of planarian locomotor activity is significantly (P<0.05) attenuated by low-energy (366 nm) ultraviolet (UV) light and to a greater extent by high-energy (254 nm) UV light. The phenomenon offers a novel approach for studying dopamine D2 receptor transduction processes in a simple in vivo model.
Raffa
R B
RB
Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA. rraffa@nimbus.temple.edu
Valdez
J M
JM
Holland
L J
LJ
Schulingkamp
R J
RJ
D000818:Animals; D018492:Dopamine Antagonists / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D010932:Planarians; D017448:Receptors, Dopamine D2 / Q000378:metabolism / Q000528:radiation effects*; D013469:Sulpiride / Q000378:metabolism / Q000494:pharmacology*; D014466:Ultraviolet Rays
D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D013469:Sulpiride