title: [Viscumin modulates neutrophil respiratory burst, caused by a chemotactic peptide].
abstract: The ability of viscum at different concentrations to modulate the respiratory burst in neutrophils, induced by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine was studied. This does not exclude the possibility that viscum can interact with the receptor of this peptide. The analysis of the primary structure of viscum revealed elements structurally analogous to the chemotactic peptide. It is assumed that viscum can exhibit the properties an antagonist of the receptor of N-formyl-methionyl-leucyl-phenylalanine, and the mechanism of action of viscum depends on its concentration.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Alovskaia
authors.forename: V G
authors.initials: VG
authors.lastname: Safronova
authors.forename: V V
authors.initials: VV
authors.lastname: Kornilov
authors.forename: A N
authors.initials: AN
authors.lastname: Kornev
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Savochkina
authors.forename: R
authors.initials: R
authors.lastname: Kraupenhaar
authors.forename: K
authors.initials: K
authors.lastname: Betzel
authors.forename: W
authors.initials: W
authors.lastname: Voelter
authors.forename: A M
authors.initials: AM
authors.lastname: Mikhaĭlov
mesh_terms: D000818:Animals; D008163:Luminescent Measurements; D051379:Mice; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D028321:Plant Preparations; D010940:Plant Proteins; D011485:Protein Binding; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic / Q000378:metabolism; D018000:Receptors, Peptide / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects*; D054790:Ribosome Inactivating Proteins, Type 2; D014118:Toxins, Biological / Q000494:pharmacology*
chemical_list: D028321:Plant Preparations; D010940:Plant Proteins; D044042:Receptors, Formyl Peptide; D011971:Receptors, Immunologic; D018000:Receptors, Peptide; D054790:Ribosome Inactivating Proteins, Type 2; D014118:Toxins, Biological; C009674:ribosome inactivating protein, Viscum; D009240:N-Formylmethionine Leucyl-Phenylalanine