title: Excretion patterns of mucosally delivered antibodies to p23 in Cryptosporidium parvum infected calves.
abstract: Fecal samples obtained at intervals from six calves with acute cryptosporidiosis contained antibodies of multiple isotypes to p23. IgM-, IgA-, and IgG(1)-isotype anti-p23 appeared before IgG(2)-isotype antibodies. All anti-p23 antibodies had declined by 2 months after infection. One calf that failed to shed oocysts following initial exposure developed IgG(1)-isotype anti-p23 antibodies. One calf that died following exposure to Cryptosporidium parvum oocysts lacked detectable anti-p23 antibodies. Re-inoculation with C. parvum resulted in a brief, marked recall response to p23.
authors.affiliation: Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, 402 Bustad Hall, Washington State University, Pullman, WA 99164-7040, USA. rwyatt@vetmed.wsu.edu
authors.forename: C R
authors.initials: CR
authors.lastname: Wyatt
authors.forename: E J
authors.initials: EJ
authors.lastname: Brackett
authors.forename: P H
authors.initials: PH
authors.lastname: Mason
authors.forename: J
authors.initials: J
authors.lastname: Savidge
authors.forename: L E
authors.initials: LE
authors.lastname: Perryman
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000913:Antibodies, Protozoan / Q000276:immunology* / Q000502:physiology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000469:parasitology; D003457:Cryptosporidiosis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D016785:Cryptosporidium parvum / Q000254:growth & development / Q000276:immunology*; D005243:Feces / Q000469:parasitology; D005434:Flow Cytometry / Q000662:veterinary; D018928:Immunity, Mucosal / Q000502:physiology*; D007118:Immunoassay / Q000662:veterinary; D007132:Immunoglobulin Isotypes / Q000276:immunology / Q000502:physiology; D008297:Male; D008863:Microspheres; D013047:Specific Pathogen-Free Organisms
chemical_list: D000913:Antibodies, Protozoan; D007132:Immunoglobulin Isotypes