title: Are ectopic or abnormal membrane hormone receptors frequently present in adrenal Cushing's syndrome?
abstract: Twenty consecutive patients with adrenal Cushing's syndrome were studied with an in vivo protocol to determine the prevalence and diversity of the presence of ectopic or abnormal hormone receptors in their adrenal tissues. All six patients with bilateral ACTH-independent macronodular adrenal hyperplasia were found to have one or two abnormal adrenal receptors, including those for gastric inhibitory polypeptide, vasopressin (V1-vasopressin), beta-adrenergic agonists, LH/human CG, or serotonin 5-HT4. The presence of abnormal hormone receptors was found to be less frequently present in unilateral adenomas or carcinomas (3 of 14). The identification of abnormal adrenal hormone receptors can allow new pharmacological therapies of hypercortisolism. We suggest that the clinical screening for the presence of abnormal hormone receptors should be conducted in patients with adrenal Cushing's syndrome and, more particularly, in those with ACTH-independent macronodular adrenal hyperplasia, in the hope of offering medical therapy as an alternative to bilateral adrenalectomy.
authors.affiliation: Department of Medicine, Research Center, H6tel-Dieu du Centre Hospitalier de l'Université de Montréal, Québec, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Mircescu
authors.forename: J
authors.initials: J
authors.lastname: Jilwan
authors.forename: N
authors.initials: N
authors.lastname: N'Diaye
authors.forename: I
authors.initials: I
authors.lastname: Bourdeau
authors.forename: J
authors.initials: J
authors.lastname: Tremblay
authors.forename: P
authors.initials: P
authors.lastname: Hamet
authors.forename: A
authors.initials: A
authors.lastname: Lacroix
mesh_terms: D000236:Adenoma / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism* / Q000473:pathology; D000312:Adrenal Hyperplasia, Congenital / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000378:metabolism; D003480:Cushing Syndrome / Q000378:metabolism*; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008566:Membranes / Q000378:metabolism; D008875:Middle Aged; D018043:Receptors, Corticotropin / Q000378:metabolism; D012964:Sodium / Q000097:blood
chemical_list: D006728:Hormones; D018043:Receptors, Corticotropin; D012964:Sodium; D006854:Hydrocortisone