title: The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies of the rat brain.
abstract: We investigated the influence of tomograph sensitivity on reliability of parameter estimation in positron emission tomography studies of the rat brain. The kinetics of two tracers in rat striatum and cerebellum were simulated. A typical injected dose of 10 MBq and a reduced dose of 1 MBq were assumed. Kinetic parameters were estimated using a region of interest (ROI) analysis and two pixel-by-pixel analyses. Striatal binding potential was estimated as a function of effective tomograph sensitivity (S(eff)) using a simplified reference tissue model. A S(eff) value of > or =1% was required to ensure reliable parameter estimation for ROI analysis and a S(eff) of 3-6% was required for pixel-by-pixel analysis. We conclude that effective tomograph sensitivity of 3% may be an appropriate design goal for rat brain imaging.
authors.affiliation: Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Sydney, Australia. steve@nucmed.rpa.cs.nsw.gov.au
authors.forename: S R
authors.initials: SR
authors.lastname: Meikle
authors.forename: S
authors.initials: S
authors.lastname: Eberl
authors.forename: R R
authors.initials: RR
authors.lastname: Fulton
authors.forename: M
authors.initials: M
authors.lastname: Kassiou
authors.forename: M J
authors.initials: MJ
authors.lastname: Fulham
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000378:metabolism; D003042:Cocaine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D003198:Computer Simulation; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism; D018492:Dopamine Antagonists / Q000493:pharmacokinetics; D065127:Dopamine D2 Receptor Antagonists; D050483:Dopamine Plasma Membrane Transport Proteins; D004305:Dose-Response Relationship, Drug; D007091:Image Processing, Computer-Assisted; D008024:Ligands; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008959:Models, Neurological; D009419:Nerve Tissue Proteins; D019047:Phantoms, Imaging; D020891:Raclopride / Q000493:pharmacokinetics; D011868:Radioisotopes / Q000493:pharmacokinetics; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000379:methods* / Q000592:standards
chemical_list: D002352:Carrier Proteins; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011868:Radioisotopes; C079213:RTI 121; D020891:Raclopride; D003042:Cocaine