Testosterone increases blood pressure and cardiovascular and renal pathology in spontaneously hypertensive rats.
The objective of this paper was to test the hypothesis that testosterone (T) raises blood pressure (BP), which is associated with increased coronary adventitial collagen, whereas the hemodynamic force of BP increases the coronary media:lumen ratio. Five treatment groups of spontaneously hypertensive rat (SHR) were established (n = 8-10 per group): controls; hydralazine (HYZ); castration; castration + HYZ; and castration + HYZ + T + captopril. At 12 weeks of age, the castrate + HYZ group was divided so that the mean BP was the same in both groups (162 mmHg). Both groups continued to receive HYZ treatment; however one group received T implants. Also, at 12 weeks of age the castrate + HYZ + T + captopril group received T implants. BP in the HYZ group was reduced compared with controls (192 mmHg vs 218 mmHg, p < 0.01). Castration lowered BP to 170 mmHg (p < 0.01) compared with controls. However, T implants increased BP by 15 mmHg (p < 0.02) in the castrate + HYZ group and by 44 mmHg in the castrate + HYZ + captopril group (p < 0.01). Captopril in combination with HYZ significantly reduced BP compared with controls but T replacement increased BP and coronary collagen deposition in spite of HYZ and captopril treatment.
Seachrist
D
D
Department of Biology, The University of Akron, Ohio 44325-3908, USA.
Dunphy
G
G
Daneshvar
H
H
Caplea
A
A
Milsted
A
A
Ely
D
D
D000804:Angiotensin II / Q000502:physiology; D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism; D003331:Coronary Vessels / Q000473:pathology; D006830:Hydralazine / Q000494:pharmacology; D006973:Hypertension / Q000473:pathology / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D009919:Orchiectomy; D051381:Rats; D011918:Rats, Inbred SHR; D013739:Testosterone / Q000494:pharmacology*
D000808:Angiotensinogen; D000804:Angiotensin II; D006830:Hydralazine; D013739:Testosterone; D003094:Collagen; D002216:Captopril