[Sensitivity of GC-MS in the detection of benzodiazepines in the urine in the form of trimethylsilyl derivatives].
A sensitive evidence of trace concentrations of benzodiazepines and their metabolites in urine can be enabled after special sample preparation including enzymatic hydrolysis, special solid phase extraction, silylation and following analysis by gas chromatography with mass spectrometry in electron impact mode. After optimalization of the procedure the extraction recovery values in the range 50-85% are achieved. The scale of retention times with basic mass spectral data are presented for the spectrum of silylated benzodiazepines which can overlap some gaps in the standard toxicological literature up to now available.
Balíková
M
M
Ustav pro toxikologii a soudní chemii, LF UK a VFN, Praha.
Maresová
V
V
Vecerková
J
J
D014151:Anti-Anxiety Agents / Q000652:urine*; D001569:Benzodiazepines; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D012680:Sensitivity and Specificity; D014297:Trimethylsilyl Compounds / Q000652:urine*
D014151:Anti-Anxiety Agents; D014297:Trimethylsilyl Compounds; D001569:Benzodiazepines