Complex inheritance: the 21st century.
At least for the early years of the twenty-first century we can anticipate some of the advances to be made in mapping, positional cloning, pooling of evidence over samples for linkage and allelic association, and fully parametric methods that combine the latter with segregation analysis. This preoccupation with problems the twentieth century failed to solve is not grounds for pessimism if the new century provides solutions and applies them to problems of biological interest. We may hope that genetic epidemiology will be part of a community that addresses the needs of geneticists for international communication, a stable nomenclature, genome databases, and a consensus on ethical, legal, and social issues transcending regional prejudices.
Morton
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Human Genetics Research Division, University of Southampton, United Kingdom.
D002874:Chromosome Mapping; D003001:Cloning, Molecular; D008040:Genetic Linkage; D006801:Humans; D008432:Mathematical Computing