title: [Influence of pre-infarction angina on mid-term mortality after acute myocardial infarction].
abstract: OBJECTIVE
  Pre-infarction angina may reduce the extent of myocardial cell necrosis and improves the prognosis after myocardial infarction. The aim of this study was to analyze the total mortality six-month after acute myocardial infarction according to the presence or absence of pre-infarction angina.
  
  
  METHODS
  One hundred seventy-five consecutive patients with acute myocardial infarction were prospectively included, 72 (41.4%) with pre-infarction angina. They were followed for 6 months. There were 16 deaths (15.5%) in the group of patients without pre-infarction angina and 7 (9.7%) in the group with pre-infarction angina (log-rank = 1.03; p = 0.311). The hazard-risk function curves showed a higher risk of death during the entire follow-up in the group without pre-infarction angina. In the multivariate logistic regression model, the presence of pre-infarction angina does not significantly reduce the risk of death (OR = 0.43; CI 95% = 0.09-2. 22; p = 0.303). We detected a significant interaction between treatment with sulfonylureas before the infarction and the presence of pre-infarction angina (p = 0.017).
  
  
  CONCLUSIONS
  In this study no significant differences were observed in total mortality six months after acute myocardial infarction according to the presence of pre-infarction angina. However, the risk of death seemed to be higher in the group of patients without pre-infarction angina during the entire follow-up. A significant interaction was found between the treatment with sulfonylurea drugs before infarction and the presence of pre-infarction angina.
authors.affiliation: Servicio de Cardiología. Hospital de León. med016340@nacom.es
authors.forename: I
authors.initials: I
authors.lastname: Iglesias Garriz
authors.forename: M
authors.initials: M
authors.lastname: Sastre Ibarretxe
authors.forename: S
authors.initials: S
authors.lastname: Delgado Fernández
authors.forename: C
authors.initials: C
authors.lastname: Garrote Coloma
authors.forename: F
authors.initials: F
authors.lastname: Corral Fernández
authors.forename: M
authors.initials: M
authors.lastname: Montes Montes
authors.forename: M A
authors.initials: MA
authors.lastname: Rodríguez García
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000150:complications*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality*; D011446:Prospective Studies; D013997:Time Factors