title: Nociceptors for the 21st century.
abstract: This review summarizes recent developments in the context of the neurochemical classification of nociceptors and explores the relationships between functionally and neurochemically defined subgroups. Although the complete picture is not yet available, several lines of intriguing evidence suggest that despite the complexity and diversity of nociceptor properties, a relatively "simple" neurochemical classification fits well with several recently identified molecular characteristics.
authors.affiliation: Department of Anatomy, School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA. Francisco.alvarez@wright.edu
authors.forename: F J
authors.initials: FJ
authors.lastname: Alvarez
authors.forename: R E
authors.initials: RE
authors.lastname: Fyffe
mesh_terms: D000818:Animals; D006801:Humans; D008465:Mechanoreceptors / Q000378:metabolism; D009412:Nerve Fibers / Q000378:metabolism; D009413:Nerve Fibers, Myelinated / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism; D009475:Neurons, Afferent / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D009619:Nociceptors / Q000378:metabolism*; D010146:Pain / Q000503:physiopathology*; D011955:Receptors, Drug / Q000378:metabolism; D011983:Receptors, Purinergic / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013697:Thermosensing / Q000502:physiology
chemical_list: D009414:Nerve Growth Factors; D009479:Neuropeptides; D011955:Receptors, Drug; D011983:Receptors, Purinergic