title: Computerised morphometrical analysis in endometrial hyperplasia for the prediction of cancer development. A long-term retrospective study from northern Norway.
abstract: OBJECTIVE
  To evaluate and compare the long term prognostic value of the WHO classification and the computerised multivariate morphometrical D score in endometrial hyperplasia. To test the reproducibility of the D score in two different centres.
  
  
  METHODS
  Histopathological WHO classification and computerised morphometrical analysis using the D score (< 0, high risk; > 1, low risk; 0-1, uncertain) in a population based study from northern Norway of archival dilatation and curettage material from 68 women with 10-20 years of follow up.
  
  
  RESULTS
  Of the 68 patients included in the study, 18 developed cancer. The sensitivity and specificity of the D score (< 0 v > 1) were 100% and 78%, respectively, which was better than the WHO classification (89% and 60%, respectively). The negative and positive predictive values for the D score were 100% and 58% and of the WHO classification 94% and 44%, respectively. This study found a slightly higher specificity for the D score than former retrospective studies, but otherwise the results were comparable. The D score results were reproducible between the two centres (R = 0.91; slope = 0.98; intercept = 0.3).
  
  
  CONCLUSIONS
  D score assessment is a reproducible and more accurate predictor of outcome of endometrial hyperplasia than the WHO classification assessed by an experienced gynaecological pathologist. Routine application of the D score might reduce over and undertreatment of endometrial hyperplasia.
authors.affiliation: Institute of Medical Biology, University of Tromsø, Norway. patano@rito.no jbaak@mca.alkmaar.nl
authors.forename: A
authors.initials: A
authors.lastname: Orbo
authors.forename: J P
authors.initials: JP
authors.lastname: Baak
authors.forename: I
authors.initials: I
authors.lastname: Kleivan
authors.forename: S
authors.initials: S
authors.lastname: Lysne
authors.forename: P S
authors.initials: PS
authors.lastname: Prytz
authors.forename: M A
authors.initials: MA
authors.lastname: Broeckaert
authors.forename: A
authors.initials: A
authors.lastname: Slappendel
authors.forename: H J
authors.initials: HJ
authors.lastname: Tichelaar
mesh_terms: D000328:Adult; D000368:Aged; D004714:Endometrial Hyperplasia / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity