[Osteoporotic fracture of the vertebral body in patients with steroid dependent bronchial asthma].
The aim of the study was an analysis of the frequency of oral steroids prescription to patients with bronchial asthma treated in hospital and of vertebral fractures and deformations as the result of GCS-induced osteoporosis in patients with bronchial asthma taking prednisolone tablets for at least 6 months. The incidence of steroid-dependent bronchial asthma (SDBA) was 12.9%. Roentgenomorphometric analysis of the thoracic and lumbar spine performed in 52 patients with SDBA revealed vertebral fractures in 11(21.1%) patients, deformations of the first and second degree in 25(48.0%) patients. Depressed fractures of the vertebra were the most numerous--14.6%. Males and females had vertebral fractures with similar frequency (21.4 and 20%, respectively). A correlation was found between the number of the affected vertebra and prednisolone treatment duration, total dose.
Lezhnina
M B
MB
Lesniak
O M
OM
Piven'
A I
AI
Lebedeva
M K
MK
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced*; D011239:Prednisolone / Q000009:adverse effects*; D016103:Spinal Fractures / Q000209:etiology*
D000893:Anti-Inflammatory Agents; D011239:Prednisolone