title: Variations in digestive physiology of rats after short duration flights aboard the US space shuttle.
abstract: The purpose of this work was to assess the influence of microgravity on several endogenous and microbial parameters of digestive physiology. On the occasion of two Spacelab Life Sciences missions, SLS-1 (a 9-day space flight) and SLS-2 (a 14-day space flight), Sprague-Dawley rats flown aboard the US space shuttle were compared to age-matched ground-based controls. In both flights, exposure to microgravity modified cecal fermentation: concentration and profile of short-chain fatty acids were altered, whereas urea and ammonia remained unchanged. Only in SLS-1 was there an induction of intestinal glutathione-S-transferase. Additional analyses in SLS-2 showed a decrease of hepatic CYP450 and of colonic goblet cells containing neutral mucin. After a postflight recovery period equal to the mission length, only modifications of the hepatic and intestinal xenobiotic metabolizing enzymes still persisted. These findings should help to predict the alterations of digestive physiology and detoxification potential likely to occur in astronauts. Their possible influence on health is discussed.
authors.affiliation: Institut National de la Recherche Agronomique, Unit on Ecology and Physiology of the Digestive Tract, Jouy-en-Josas, France.
authors.forename: S
authors.initials: S
authors.lastname: Rabot
authors.forename: O
authors.initials: O
authors.lastname: Szylit
authors.forename: L
authors.initials: L
authors.lastname: Nugon-Baudon
authors.forename: J C
authors.initials: JC
authors.lastname: Meslin
authors.forename: P
authors.initials: P
authors.lastname: Vaissade
authors.forename: F
authors.initials: F
authors.lastname: Popot
authors.forename: M
authors.initials: M
authors.lastname: Viso
mesh_terms: D000818:Animals; D002432:Cecum / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005285:Fermentation; D005982:Glutathione Transferase / Q000378:metabolism; D006632:Histamine / Q000378:metabolism; D006651:Histocytochemistry; D007413:Intestinal Mucosa / Q000166:cytology* / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D008099:Liver / Q000201:enzymology; D008297:Male; D009077:Mucins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013026:Space Flight; D014893:Weightlessness
chemical_list: D009077:Mucins; D006632:Histamine; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase