Synthesis and evaluation of microtubule assembly inhibition and cytotoxicity of prenylated derivatives of cyclo-L-Trp-L-Pro.
The synthesis of three isoprenylated derivatives of cyclo-L-Trp-L-Pro is described. These substances have been evaluated for cytotoxic activity in rat normal fibroblast 3Y1 cells and have also been evaluated in vitro for the inhibition of microtubule assembly.
Sanz-Cervera
J F
JF
Departamento de Química Orgánica, Universidad de Valencia, Spain.
Stocking
E M
EM
Usui
T
T
Osada
H
H
Williams
R M
RM
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D026121:Indole Alkaloids; D007211:Indoles / Q000494:pharmacology*; D008869:Microtubule-Associated Proteins / Q000032:analysis; D008870:Microtubules / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D010879:Piperazines; D017368:Protein Prenylation; D051381:Rats
D026121:Indole Alkaloids; D007211:Indoles; D008869:Microtubule-Associated Proteins; D010456:Peptides, Cyclic; D010879:Piperazines; C097859:tryprostatin B