title: A convenient strategy for the synthesis of 4,5-bis(o-haloaryl)isoxazoles
abstract: A series of new 1,2-bis(o-haloaryl)ethanones is efficiently prepared and applied to the synthesis of 4,5-bis(o-haloaryl)isoxazoles. Isolation of intermediate hydroxyisoxazolines, which are structurally examined, provides a definitive proof for a heterocyclization mechanism based on an amine exchange process. The isolation and X-ray crystallographic studies of significant side products such as benzamides and triarylpropionitriles are also described.
authors.affiliation: Kimika Organikoa Saila, Zientzi Fakultatea, Euskal Herriko Unibertsitatea, Bilbao, Spain.
authors.initials: R
authors.lastname: Olivera
authors.initials: R
authors.lastname: SanMartin
authors.initials: E
authors.lastname: Dominguez
authors.initials: X
authors.lastname: Solans
authors.initials: MK
authors.lastname: Urtiaga
authors.initials: MI
authors.lastname: Arriortua