title: Bolus-chase peripheral 3D MRA using a dual-rate contrast media injection.
abstract: In this pilot study, using a standard 40 mL gadolinium (Gd) chelate contrast dose, dual-rate (first 20 mL at 0.5 mL/sec; remaining 20 mL at 1.5 mL/sec) and fixed-rate (entire 40 mL dose at either 0.7 mL/sec or 2.0 mL/sec) injection schemes for multistation, bolus-chase magnetic resonance angiography (MRA) were compared in normal volunteers. Signal-to-noise ratio, contrast-to-noise ratio, and physician preference were determined for nine arterial segments. At the terminal station (calf), the dual-rate contrast injection improved arterial signal and contrast compared with both fixed-rate injection schemes and improved subjective vessel appearance compared with the 2.0 mL/sec, but not the 0.7 mL/sec, fixed-rate scheme.
authors.affiliation: Department of Radiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Czum
authors.forename: V B
authors.initials: VB
authors.lastname: Ho
authors.forename: M N
authors.initials: MN
authors.lastname: Hood
authors.forename: T K
authors.initials: TK
authors.lastname: Foo
authors.forename: P L
authors.initials: PL
authors.lastname: Choyke
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001158:Arteries / Q000033:anatomy & histology; D003287:Contrast Media; D004305:Dose-Response Relationship, Drug; D005260:Female; D005682:Gadolinium; D006801:Humans; D007275:Injections, Intravenous; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011856:Radiographic Image Enhancement; D012016:Reference Values; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D003287:Contrast Media; D005682:Gadolinium