title: Effects of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats with sciatic nerve ligation.
abstract: Galanin is a 29-amino acid peptide with a suggested role in nociception. The effect of galanin on wide-dynamic range neuron discharge frequency in rats with nerve ligation, used as a model of neurogenic pain, was investigated by extracellular recording methods. Seven to 14 days after sciatic nerve ligation, 0.1, 0.5 or 1 nmol of galanin was administered directly on the dorsal surface of the L3-L5 spinal cord of rats with sciatic nerve ligation. It was found that galanin inhibited the activity of wide-dynamic range neurons dose-dependently, an effect was more pronounced in sciatic nerve ligated rats than intact rats. Furthermore, when 1 nmol of galantide, the galanin antagonist, was administered on the dorsal surface of the L3-L5 spinal cord, the wide-dynamic range neuron discharge frequency increased significantly. The results suggest that galanin plays an important role in the modulation of presumed nociception in mononeuropathy.
authors.affiliation: Department of Physiology, College of Life Sciences, and National Laboratory of Biomembranes and Membrane Biotechnology, Peking University, 100871, Beijing, PR China.
authors.forename: S
authors.initials: S
authors.lastname: Xu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Lundeberg
authors.forename: L
authors.initials: L
authors.lastname: Yu
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D019004:Galanin / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D020671:Posterior Horn Cells / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044088:Receptors, Galanin; D018013:Receptors, Neuropeptide / Q000502:physiology; D012584:Sciatic Nerve / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
chemical_list: D044088:Receptors, Galanin; D018013:Receptors, Neuropeptide; C074975:galantide; D013373:Substance P; D019004:Galanin