Protection against lipopolysaccharide-induced death by fluoroquinolones.
Because fluoroquinolones have an immunomodulatory effect on cytokine production by lipopolysaccharide (LPS)-treated human monocytes, we examined the effect of fluoroquinolones on the survival of mice injected with a lethal dose of LPS. Trovafloxacin (100 mg/kg), ciprofloxacin (250 mg/kg), and tosufloxacin (100 mg/kg) protected 75% (P = 0.0001), 25% (P = 0.002), and 50% (P = 0.002), respectively, of mice against death. The fluoroquinolones significantly reduced serum levels of interleukin-6 and tumor necrosis factor alpha in LPS-treated mice. The protective effects of fluoroquinolones in LPS-induced shock in mice may also occur in humans.
Khan
A A
AA
Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, Palo Alto, California 94301, USA.
Slifer
T R
TR
Araujo
F G
FG
Suzuki
Y
Y
Remington
J S
JS
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood; D003643:Death; D004347:Drug Interactions; D024841:Fluoroquinolones; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000166:cytology / Q000187:drug effects*; D009287:Naphthyridines / Q000627:therapeutic use; D020011:Protective Agents / Q000627:therapeutic use*; D012772:Shock, Septic / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D016207:Cytokines; D024841:Fluoroquinolones; D008070:Lipopolysaccharides; D009287:Naphthyridines; D020011:Protective Agents; D002939:Ciprofloxacin; C080163:trovafloxacin