title: Antiphase oscillation of the left and right suprachiasmatic nuclei.
abstract: An unusual property of the circadian timekeeping systems of animals is rhythm "splitting," in which a single daily period of physical activity (usually measured as wheel running) dissociates into two stably coupled components about 12 hours apart; this behavior has been ascribed to a clock composed of two circadian oscillators cycling in antiphase. We analyzed gene expression in the hypothalamic circadian clock, the suprachiasmatic nucleus (SCN), of behaviorally "split" hamsters housed in constant light. The results show that the two oscillators underlying the split condition correspond to the left and right sides of the bilaterally paired SCN.
authors.affiliation: Department of Neurology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. hacho@bio.umass.edu
authors.forename: H O
authors.initials: HO
authors.lastname: de la Iglesia
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: A
authors.initials: A
authors.lastname: Carpino
authors.forename: W J
authors.initials: WJ
authors.lastname: Schwartz
mesh_terms: D056930:ARNTL Transcription Factors; D000818:Animals; D001127:Arginine Vasopressin / Q000235:genetics / Q000378:metabolism; D051792:Basic Helix-Loop-Helix Proteins; D001683:Biological Clocks / Q000502:physiology*; D018797:Cell Cycle Proteins; D002940:Circadian Rhythm / Q000502:physiology*; D006224:Cricetinae; D015870:Gene Expression; D018257:Helix-Loop-Helix Motifs; D017403:In Situ Hybridization; D008027:Light; D008297:Male; D008647:Mesocricetus; D009043:Motor Activity; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D056950:Period Circadian Proteins; D013493:Suprachiasmatic Nucleus / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D056930:ARNTL Transcription Factors; D001127:Arginine Vasopressin; D051792:Basic Helix-Loop-Helix Proteins; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D056950:Period Circadian Proteins; D014157:Transcription Factors; C538961:Bmal1 protein, mouse; C513312:Per2 protein, mouse; C512645:Per3 protein, mouse