Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease.
An association between altered risk of Alzheimer's disease (AD) and the interleukin-1A (IL-1A) gene was recently reported in two independent studies. Here, the IL-1A polymorphism was analyzed in a third population of 247 AD patients and 187 control individuals. In support of the published findings, the IL-1A 2/2 genotype was associated with an increased risk of early onset AD (odds ratio of 3.1, P = 0.02). Clinically, the IL-1A 2/2 genotype was associated with an earlier age of onset, but not with a change in the rate of progression of AD.
Rebeck
G W
GW
Alzheimer Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA. rebeck@helix.mgh.harvard.edu
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012016:Reference Values
D007375:Interleukin-1