[Study of association between the magnitude of sphincter hypotonia and esophageal motor disorders].
BACKGROUND
One of the most important factors involved in the pathophysiology of gastroesophageal reflux disease (GERD) is the lower esophageal sphincter rest pressure (LESRP), but these patients can have esophageal motor disorders (EMD).


OBJECTIVE
To assess an association between LESRP and the appearance of EMD in patients with GERD.


METHODS
A cross-sectional study was conducted in 229 patients with GERD and 49 healthy controls. Forty five patients with LESRP < 6 mmHg and a mean age of 49 years were assigned to group 1, 128 patients with a LESRP between 6 and 12 mmHg and mean age of 47 years were assigned to group 2, 56 patients with a a LESRP > 12 mmHg and a mean age of 47 years were assigned to group 3 and group 4 was conformed by 49 healthy subjects aged 40 years old. Esophageal manometry was performed using previously published techniques.


RESULTS
There was a significant association between LESRP, waves amplitude and the frequency of tertiary waves.


CONCLUSIONS
Resting lower esophageal sphincter pressure is inversely proportional to the presence of esophageal motor disorders in patients with gastroesophageal reflux disease.
Manterola
C
C
Departamento de Cirugía, Facultad de Medicina, Universidad de la Frontera, Temuco, Chile. cmantero@ufro.cl
Muñoz
S
S
Flores
P
P
Fernández
E
E
Capurro
M
M
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D015154:Esophageal Motility Disorders / Q000150:complications / Q000503:physiopathology*; D004943:Esophagogastric Junction / Q000503:physiopathology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000150:complications / Q000503:physiopathology*