title: Diuretic therapy and the risk for renal cell carcinoma.
abstract: Diuretics are important drugs in the treatment of arterial hypertension, congestive heart failure, the nephrotic syndrome, and other clinical conditions. With diuretic treatment, reduction of both morbidity and mortality has been clearly shown in those conditions. However, a recent meta-analysis showed an increased risk for renal cell carcinoma in patients treated with diuretics. We summarize and critically review data from studies examining the association between diuretic use and renal cell carcinoma. In general, in many clinical conditions, the reduction of mortality with diuretic therapy outweighs a potential risk of renal cell carcinoma. However, in certain conditions, alternative medical treatment should be considered.
authors.affiliation: Department of Medicine/Nephrology, University of Erlangen-Nürnberg, Germany. roland.schmieder@rzmail.uni-erlangen.de
authors.forename: R E
authors.initials: RE
authors.lastname: Schmieder
authors.forename: C
authors.initials: C
authors.lastname: Delles
authors.forename: F H
authors.initials: FH
authors.lastname: Messerli
mesh_terms: D002292:Carcinoma, Renal Cell / Q000139:chemically induced* / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000188:drug therapy; D016022:Case-Control Studies; D015331:Cohort Studies; D004232:Diuretics / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D015994:Incidence; D007680:Kidney Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D018570:Risk Assessment; D017678:Sex Distribution; D014481:United States / Q000453:epidemiology
chemical_list: D004232:Diuretics