title: Insulin-like growth factor binding protein-1 (IGFBP-1): a multifunctional role in the human female reproductive tract.
abstract: Insulin-like growth factor-1 (IGFBP-1) is particularly important in human female reproductive physiology, where it is involved with other factors in a complex system which regulates menstrual cycles, puberty, ovulation, decidualization, implantation and fetal growth. This has implications for clinical obstetrics and gynaecology, where there is evidence for a pathophysiological role for IGFBP-1 in pre-eclampsia, intrauterine growth restriction, polycystic ovarian syndrome and trophoblast and endometrial neoplasms.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, Department of Obstetrics and Gynaecology, King's College Hospital, London UK. djfowler@partners.org
authors.forename: D J
authors.initials: DJ
authors.lastname: Fowler
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
authors.forename: J P
authors.initials: JP
authors.lastname: Miell
mesh_terms: D010064:Embryo Implantation / Q000502:physiology; D005314:Embryonic and Fetal Development; D004717:Endometrium / Q000502:physiology; D005260:Female; D005836:Genitalia, Female / Q000502:physiology*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000235:genetics / Q000502:physiology*; D010053:Ovary / Q000473:pathology / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology; D011247:Pregnancy; D012098:Reproduction / Q000235:genetics / Q000502:physiology*; D013002:Somatomedins / Q000502:physiology
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D013002:Somatomedins