title: Expression and localization of prohormone convertase 1/3 (SPC3) in porcine ovary.
abstract: Tissue distribution and cellular localization of PC1/3 mRNA in porcine tissues were examined by ribonuclease protection assay and in situ hybridization. PC1/3 mRNA was detected mainly in the corpus luteum of pregnant sow and brain. Within the ovary, PC1/3 and relaxin transcripts colocalized within large luteal cells. Levels of PC1/3 transcripts in corpora lutea increased as gestation advanced, parallel with an observed increase in relaxin transcripts. A role for PC1/3 in proprotein processing in the ovary is discussed.
authors.affiliation: Department of Anatomy and Cell Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Renegar
authors.forename: C R
authors.initials: CR
authors.lastname: Owens
authors.forename: G
authors.initials: G
authors.lastname: Dai
authors.forename: J P
authors.initials: JP
authors.lastname: McMurtry
authors.forename: S C
authors.initials: SC
authors.lastname: Kwok
mesh_terms: D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D010053:Ovary / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D043484:Proprotein Convertases; D013552:Swine; D014018:Tissue Distribution
chemical_list: D043484:Proprotein Convertases; D016282:Aspartic Acid Endopeptidases