title: Imaging evaluation of the response of high-grade osteosarcoma and Ewing sarcoma to chemotherapy with emphasis on dynamic contrast-enhanced magnetic resonance imaging.
abstract: Response of high-grade osteosarcoma and Ewing sarcoma to preoperative chemotherapy can significantly affect the surgical approach to patients with these tumors and their disease-free survival. This article presents the findings and limitations of different imaging modalities (radiography, angiography, sonography, scintigraphy, and magnetic resonance [MR] imaging and spectroscopy) for evaluating this chemotherapeutic response. Particular emphasis is given to the currently most effective modality--dynamic contrast-enhanced MR imaging.
authors.affiliation: Department of Radiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Shapeero
authors.forename: D
authors.initials: D
authors.lastname: Vanel
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003287:Contrast Media; D003952:Diagnostic Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media