title: Collagen patch coated with fibrin glue components. Treatment of suture hole bleedings in vascular reconstruction.
abstract: BACKGROUND
  Bleeding from suture holes during vascular reconstruction, particularly when polytetrafluoroethylene (PTFE) prostheses are used, is still a problem which can lead to intraoperative delay and increased blood loss. The aim of this prospective, randomised, open, controlled multicentre study was to evaluate whether the use of a new local haemostyptic would reduce intraoperative blood loss and the time to haemostasis.
  
  
  METHODS
  Thirty patients received a new haemostyptic (TachoComb H, Nycomed Pharma AG), whereas another 30 patients were treated with compresses. The vascular reconstructions were either anastomoses or patch angioplasties and were performed using PTFE vascular prostheses.
  
  
  RESULTS
  The mean time to haemostasis of suture hole bleeding in the haemostyptic group (326.0 sec) was significantly shorter compared to the control group (514.3 sec) (p=0.006). The median intraoperative blood loss was 24.5 g in the treatment group and 57.3 g in the control group (p=0.045).
  
  
  CONCLUSIONS
  It was shown that collagen patches coated with components of fibrin glue significantly reduce the time to haemostasis as well as blood loss at the operation site in patients undergoing vascular reconstruction with PTFE grafts.
authors.affiliation: Department of Surgery, University of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Czerny
authors.forename: F
authors.initials: F
authors.lastname: Verrel
authors.forename: H
authors.initials: H
authors.lastname: Weber
authors.forename: N
authors.initials: N
authors.lastname: Müller
authors.forename: L
authors.initials: L
authors.lastname: Kircheis
authors.forename: W
authors.initials: W
authors.lastname: Lang
authors.forename: B
authors.initials: B
authors.lastname: Steckmeier
authors.forename: W
authors.initials: W
authors.lastname: Trubel
mesh_terms: D000368:Aged; D019917:Blood Vessel Prosthesis Implantation; D003094:Collagen; D005260:Female; D015718:Fibrin Tissue Adhesive; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D007431:Intraoperative Complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D011446:Prospective Studies; D013537:Sutures
chemical_list: D015718:Fibrin Tissue Adhesive; D011138:Polytetrafluoroethylene; D003094:Collagen