Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats.
STATEMENT OF FINDINGS: This study describes the upregulation of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion (DRG) neurons in the course of antigen-induced arthritis (AIA) in the rat knee. In the acute phase of AIA, which was characterized by pronounced hyperalgesia, there was a substantial bilateral increase in the proportion of lumbar DRG neurons that express neurokinin 1 receptors (activated by substance P) and bradykinin 2 receptors. In the chronic phase the upregulation of bradykinin 2 receptors persisted on the side of inflammation. The increase in the receptor expression is relevant for the generation of acute and chronic inflammatory pain.
von Banchet
G S
GS
University of Jena, Jena, Germany.
Petrow
P K
PK
Bräuer
R
R
Schaible
H G
HG
D000818:Animals; D000941:Antigens / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism*; D007719:Knee Joint / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010146:Pain / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D011917:Rats, Inbred Lew; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin / Q000378:metabolism*; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology*
D000941:Antigens; D043782:Receptor, Bradykinin B2; D018002:Receptors, Bradykinin; D018040:Receptors, Neurokinin-1