Effect of a new international reference preparation for proteins in human serum (certified reference material 470) on results of the College of American Pathologists Surveys for plasma proteins.
OBJECTIVE
To examine the impact of a new international reference preparation for serum proteins on the among-manufacturer variance in the College of American Pathologists Surveys.


METHODS
The results of the Surveys for the years 1993-1998, supplied by the College of American Pathologists.


METHODS
Mean values for manufacturers' assays were compared for each protein in the quality control samples. Results were separated by the reported reference material from which values for calibrators had been transferred. Standard statistical parameters (means, standard deviations, and coefficients of variation) were calculated from the reported means.


CONCLUSIONS
Among-manufacturer coefficients of variation have dropped significantly for most serum proteins since the introduction of the new reference material. Possible reasons for continued differences are discussed.
Johnson
A M
AM
Committee on Plasma Proteins, International Federation for Clinical Chemistry, Chapel Hill, NC, USA.
Whicher
J T
JT
Ledue
T B
TB
Carlström
A
A
Itoh
Y
Y
Petersen
P H
PH
D000418:Albumins / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis / Q000592:standards*; D002097:C-Reactive Protein / Q000032:analysis; D002568:Certification; D002570:Ceruloplasmin / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D010338:Pathology, Clinical / Q000592:standards*; D011786:Quality Control; D012015:Reference Standards; D015203:Reproducibility of Results; D012955:Societies, Medical; D014168:Transferrin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000418:Albumins; D001798:Blood Proteins; D003176:Complement C3; D003181:Complement C4; D006242:Haptoglobins; D007136:Immunoglobulins; D014168:Transferrin; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein; D002570:Ceruloplasmin