[Study of lipid peroxidation inhibition in human blood by several endogenous and exogenous compounds].
Numerous studies suggest that lipid peroxidation is involved in the atherosclerosis and hemolytic disease processes. Nicanartine improves in vitro resistance of LDL (low density lipoproteins) to oxidation in the conjugated dienes model. Polarographic assays show that hemin-bound drugs inhibit erythrocyte membrane peroxidation. A method to measure the antioxidant capacity of plasma is proposed and tested in sickle cell disease. These in vitro results suggest drugs and drugs combination which could be efficient to inhibit lipid peroxidation in vivo.
Dailly
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Groupe Hospitalier Pitié Salpêtrière, Service Pharmacie - Laboratoire de toxicologie et de suivi thérapeutique, 47-83, boulevard de l'Hôpital, F 75651 Paris Cedex 13.
D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood*
D000975:Antioxidants; D008054:Lipid Peroxides