Thrombin-induced platelet microbicidal protein susceptibility phenotype influences the outcome of oxacillin prophylaxis and therapy of experimental Staphylococcus aureus endocarditis.
We previously showed that in vitro susceptibility profiles of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 (tPMP-1) impacted the outcome of vancomycin treatment in experimental infective endocarditis. In this same model, treatment with oxacillin (a more rapid staphylocidal agent than vancomycin) enhanced the clearance of both tPMP-1-susceptible and -resistant cells from vegetations. The extent of clearance was greater for tPMP-1-susceptible cells.
Dhawan
V K
VK
Division of Infectious Diseases, Charles Drew University-Martin Luther King Medical Center, Los Angeles, California 90059, USA. vidhawan@cdrewu.edu
Bayer
A S
AS
Yeaman
M R
MR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001798:Blood Proteins / Q000494:pharmacology*; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000517:prevention & control*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D010641:Phenotype; D011817:Rabbits; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000187:drug effects; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D010406:Penicillins; C077150:platelet microbicidal protein, Oryctolagus cuniculus; D010068:Oxacillin