title: Investigation of gastro-oesophageal reflux in patients with an intact stomach: is oesophageal bilirubin monitoring a useful addition to pH monitoring?
abstract: OBJECTIVE
  Ambulatory bilirubin monitoring has helped to establish the role of duodenal contents in gastro-oesophageal reflux disease. This study aims to define the clinical role of oesophageal bilirubin monitoring in reflux patients with an intact stomach.
  
  
  METHODS
  In total, 113 consecutive patients with reflux symptoms were prospectively studied using combined ambulatory oesophageal pH and bilirubin monitoring. Patients were categorized as follows: no pathological reflux, isolated acid reflux, isolated bilirubin reflux, combined acid and bilirubin reflux.
  
  
  RESULTS
  Thirty-eight patients (33%) had no pathological reflux, 49 patients (44%) had combined pathological acid and bilirubin reflux, and 17 patients (15%) had isolated pathological acid reflux. Only nine patients (8%) had isolated pathological bilirubin reflux. In these nine, the extent of pathological bilirubin reflux was small (median total bilirubin exposure time 12.2%, range 6.5%-20.7%) and mucosal damage was minimal (five had grade 1 oesophagitis, four had a normal oesophagus). In one patient, symptoms were temporally related to acid reflux, and in none were symptoms temporally related to bilirubin reflux.
  
  
  CONCLUSIONS
  Isolated oesophageal bilirubin reflux in patients with an intact stomach is uncommon. In these patients mucosal injury is minimal, and reflux symptoms are not related to bilirubin reflux episodes. Further work is needed to define the role for oesophageal bilirubin monitoring in the investigation of reflux disease in patients with an intact stomach.
authors.affiliation: Dept. of Surgery, Guy's Hospital, London.
authors.forename: R E
authors.initials: RE
authors.lastname: Marshall
authors.forename: A
authors.initials: A
authors.lastname: Anggiansah
authors.forename: W A
authors.initials: WA
authors.lastname: Owen
authors.forename: W J
authors.initials: WJ
authors.lastname: Owen
mesh_terms: D001663:Bilirubin / Q000032:analysis*; D016022:Case-Control Studies; D004383:Duodenogastric Reflux / Q000175:diagnosis; D004942:Esophagitis, Peptic / Q000175:diagnosis*; D004947:Esophagus / Q000378:metabolism*; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D011446:Prospective Studies; D013270:Stomach
chemical_list: D001663:Bilirubin