Chemiluminescent method for determination of tetracycline, chlortetracycline, minocycline, doxycycline, and demeclocycline.
A chemiluminescent method is described for the determination of tetracycline, chlortetracycline, minocycline, doxycycline, and demeclocycline. The method is based on the photon counting technique and the spline functions approximation. The simple formula S = b + Ax(2) is proposed for the observed dependency of the integrated number of countings S on the concentration x of a given antibiotic. The correlation between S and the half-life of a drug in the human body is proved.
Marczyński
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Institute of Physics, Technical University of Szczecin, Al. Piastow 48/49, 70-310 Szczecin, Poland. slawek@arcadia.tuniv.szczecin.pl
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D008163:Luminescent Measurements; D008670:Metals; D008722:Methods; D016877:Oxidants; D013696:Temperature; D013754:Tetracyclines / Q000032:analysis* / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D008670:Metals; D016877:Oxidants; D013754:Tetracyclines