title: Insight into acid-mediated asymmetric spirocyclization in the presence of a chiral diol.
abstract: Asymmetric spirocyclization based on intramolecular conjugate addition using a combination of a Lewis acid and an optically active cyclohexane-1,2-diol has been studied in connection with 1) the effect of substituents on the cyclohexane-1,2-diol and 2) the effect of substituents on the substrate. This reaction was found to be both thermodynamically and kinetically controlled under restricted conditions.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kiguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tsurusaki
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Aso
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Suemune
mesh_terms: D000143:Acids / Q000737:chemistry*; D003511:Cyclohexanols / Q000737:chemistry*; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: D000143:Acids; D003511:Cyclohexanols; C064619:1,2-cyclohexanediol