title: The role of type III collagen in family members of patients with abdominal aortic aneurysms.
abstract: OBJECTIVE
  type III collagen is responsible for the tensile strength of the aorta-wall. To determine if genetic defect in the type III collagen production is associated with familial clustering of AAA.
  
  
  METHODS
  fifty-six patients with AAA and 82 first-degree family members participated. The medical and family histories were obtained. All these relatives were screened by ultrasound for AAA. In 58 relatives of 20 families, skin biopsies were taken for protein analysis to measure type III collagen production in cultured fibroblasts.
  
  
  RESULTS
  only one new AAA was detected in a brother of a patient. Four other relatives were already known with AAA. Three AAA patients had a type III collagen deficiency, but type III collagen was normal in all family members.
  
  
  CONCLUSIONS
  type III collagen deficiency does not appear to be an aetiological factor in the development of AAA.
authors.affiliation: Institute for CardioVascular Research, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: van Keulen
authors.forename: E
authors.initials: E
authors.lastname: van den Akker
authors.forename: F G
authors.initials: FG
authors.lastname: van den Berg
authors.forename: G
authors.initials: G
authors.lastname: Pals
authors.forename: J A
authors.initials: JA
authors.lastname: Rauwerda
mesh_terms: D000328:Adult; D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D003094:Collagen / Q000172:deficiency* / Q000235:genetics*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012016:Reference Values; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014463:Ultrasonography
chemical_list: D003094:Collagen