[The effect of sodium alpha-ketoglutarate on the indices of the peripheral blood and lipid peroxidation and on the enzyme activity of antioxidant protection in irradiated rats].
The influence of chronic roentgen irradiation in low doses on rats' quantitative and qualitative indices of peripheral blood, on lipid peroxidation and on erythrocyte antioxidant enzymes activity has been studied. It was shown that chronic roentgen irradiation in low doses had a destabilizing influence on leucocytes correlation, activated lipid peroxidation, depressed activity of erythrocytes antioxidant enzymes. Alpha-ketoglutarate injection in therapeutic doses normalized blood indices, limited the intensity of lipid peroxidation and activated antioxidant system enzymes.
Horyn'
O V
OV
I. Franko National University, Lviv.
Kurhaliuk
N M
NM
D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D007656:Ketoglutaric Acids / Q000627:therapeutic use*; D007962:Leukocytes / Q000187:drug effects / Q000528:radiation effects; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats
D000975:Antioxidants; D007656:Ketoglutaric Acids; D011837:Radiation-Protective Agents; D008315:Malondialdehyde