title: Receptors coupling to G proteins: is there a signal behind the sequence?
abstract: Upon the binding of their ligands, G protein-coupled receptors couple to the heterotrimeric G proteins to transduce a signal. One receptor family may couple to a single G protein subtype and another family to several ones. Is there a signal in the receptor sequence that can give an indication of the G protein subtype selectivity? We used a sequence analysis method on biogenic amine and adenosine receptors and concluded that a weak signal can be detected in receptor families where specialization for coupling to a given G protein occurred during a recent divergent evolutionary process. Proteins 2000;41:448-459.
authors.affiliation: BIOcomputing, European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Horn
authors.forename: E M
authors.initials: EM
authors.lastname: van der Wenden
authors.forename: L
authors.initials: L
authors.lastname: Oliveira
authors.forename: A P
authors.initials: AP
authors.lastname: IJzerman
authors.forename: G
authors.initials: G
authors.lastname: Vriend
mesh_terms: D000465:Algorithms; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence / Q000502:physiology; D016208:Databases, Factual; D019143:Evolution, Molecular; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009154:Mutation / Q000502:physiology; D010802:Phylogeny; D011941:Receptors, Adrenergic / Q000737:chemistry; D017982:Receptors, Biogenic Amine / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000737:chemistry*; D011976:Receptors, Muscarinic / Q000737:chemistry; D018047:Receptors, Purinergic P1 / Q000737:chemistry; D015398:Signal Transduction
chemical_list: D008024:Ligands; D011941:Receptors, Adrenergic; D017982:Receptors, Biogenic Amine; D011956:Receptors, Cell Surface; D011976:Receptors, Muscarinic; D018047:Receptors, Purinergic P1; D019204:GTP-Binding Proteins