title: Exemestane improves survival compared with megoestrol acetate in postmenopausal patients with advanced breast cancer who have failed on tamoxifen. results Of a double-blind randomised phase III trial.
abstract: Exemestane is an aromatase inactivator. 769 Postmenopausal women with advanced breast cancer who had failed on tamoxifen were randomised to exemestane or megoestrol acetate in this double-blind trial. Objective response rate was similar between treatments. Median time to progression, time to treatment failure and overall survival was significantly longer with exemestane. Drug-related withdrawals and drug-related deaths were more common with megoestrol acetate.
authors.affiliation: Universitätsklinik, Goethe-Universität, 60596, Frankfurt, Germany. m.kaufmann@em.uni-frankfurt.de
authors.forename: M
authors.initials: M
authors.lastname: Kaufmann
authors.forename: E
authors.initials: E
authors.lastname: Bajetta
authors.forename: L Y
authors.initials: LY
authors.lastname: Dirix
authors.forename: L E
authors.initials: LE
authors.lastname: Fein
authors.forename: S E
authors.initials: SE
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Cervek
authors.forename: C
authors.initials: C
authors.lastname: Fowst
authors.forename: A
authors.initials: A
authors.lastname: Polli
authors.forename: E
authors.initials: E
authors.lastname: Di Salle
authors.forename: G
authors.initials: G
authors.lastname: Massimini
authors.forename: G
authors.initials: G
authors.lastname: Piscitelli
mesh_terms: D000730:Androstadienes / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004311:Double-Blind Method; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D019290:Megestrol Acetate / Q000627:therapeutic use*; D017698:Postmenopause; D016019:Survival Analysis; D013629:Tamoxifen / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D000730:Androstadienes; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D013629:Tamoxifen; C056516:exemestane; D019290:Megestrol Acetate