Abrogation of negative selection by GVHR induced by minor histocompatibility antigens or H-2D antigen alone.
Allogeneic bone marrow chimeras were prepared by donor and recipient combinations that differed in minor histocompatibility loci or H-2D locus alone. When 1 x 10(5) splenic T cells were inoculated in addition to T cell-depleted bone marrow cells (1 x 10(7)), clinically detectable GVHR was induced. In these GVHR chimeras, substantial numbers of T cells reactive to either donor or recipient antigens were both phenotypically and functionally detected. The mechanisms underlying the abrogation of intrathymic negative selection are discussed.
Morohashi
T
T
Division of Immunobiology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Ogasawara
K
K
Kitaichi
N
N
Iwabuchi
K
K
Onoé
K
K
D000818:Animals; D000941:Antigens / Q000276:immunology; D017690:Cell Transplantation; D002678:Chimera; D006086:Graft vs Host Disease / Q000276:immunology*; D006183:H-2 Antigens / Q000276:immunology*; D064532:Histocompatibility Antigen H-2D; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D015778:Minor Histocompatibility Antigens / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D006183:H-2 Antigens; D064532:Histocompatibility Antigen H-2D; D015778:Minor Histocompatibility Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta