title: The cumbiasins, structurally novel diterpenes possessing intricate carbocyclic skeletons from the West Indian sea whip Pseudopterogorgia elisabethae (Bayer).
abstract: From the hexane extract of the West Indian gorgonian Pseudopterogorgia elisabethae, two diterpenes, cumbiasins A (1) and B (2), having a novel tetracyclic carbon skeleton named cumbiane, have been isolated. In addition, we have isolated cumbiasin C (3), a ring cleavage product of cumbiasin B that possesses an unusual carbocyclic framework named seco-cumbiane. The structures and relative configurations of metabolites 1-3 were elucidated by interpretation of overall spectral data, which included 2D NMR correlation methods, IR, UV, and accurate mass measurements (HREI-MS and HRFAB-MS). The carbocyclic skeletons of the cumbiasins are unprecedented and represent new classes of C20 rearranged diterpenes. Cumbiasins A and B display mild in vitro anti-tuberculosis activity.
authors.affiliation: Department of Chemistry, University of Puerto Rico, San Juan 00931-3346, USA. arodrig@goliath.cnnet.clu.edu
authors.forename: A D
authors.initials: AD
authors.lastname: Rodríguez
authors.forename: C
authors.initials: C
authors.lastname: Ramírez
authors.forename: Y P
authors.initials: YP
authors.lastname: Shi
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry* / Q000302:isolation & purification; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013055:Spectrophotometry, Infrared
chemical_list: D000995:Antitubercular Agents; D004224:Diterpenes