title: Ductal carcinoma in situ diagnosed with stereotactic core needle biopsy: can invasion be predicted?
abstract: OBJECTIVE
  To determine whether mammographic or histologic features can be used to predict which cases diagnosed as ductal carcinoma in situ (DCIS) without invasion by means of stereotactic core needle biopsy (SCNB) will have invasive disease at surgery.
  
  
  METHODS
  From July 1992 to March 1999, DCIS without invasion was diagnosed by means of SCNB in 59 patients. Seventeen (29%) were found to have invasive disease after surgery. The underestimation rate for SCNB was compared with that obtained by means of open surgical biopsy. Mammographic and histologic features of cases with and those without invasion were compared.
  
  
  RESULTS
  All patients had calcifications on mammograms. There was no significant difference (P: =.26) between the underestimation rate for SCNB with the 11-gauge vacuum-assisted device and that for open surgical biopsy. No statistically significant differences between cases with and those without invasion were seen in patient age, mean number of core specimens, level of suspicion, size of lesion, distribution and morphology of the calcifications, presence of an associated mass or density, subtype of DCIS, nuclear grade, or presence of necrosis or desmoplasia.
  
  
  CONCLUSIONS
  Mammographic and histologic features cannot be used reliably to predict cases that are underestimated with SCNB. However, SCNB with the 11-gauge vacuum-assisted device was as reliable as open surgical biopsy for diagnosing DCIS without invasion.
authors.affiliation: Department of Diagnostic Radiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA. LeeC@biomed.med.Yale.edu
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
authors.forename: D
authors.initials: D
authors.lastname: Carter
authors.forename: L E
authors.initials: LE
authors.lastname: Philpotts
authors.forename: M E
authors.initials: ME
authors.lastname: Couce
authors.forename: L J
authors.initials: LJ
authors.lastname: Horvath
authors.forename: R C
authors.initials: RC
authors.lastname: Lange
authors.forename: I
authors.initials: I
authors.lastname: Tocino
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D013238:Stereotaxic Techniques