Synthesis of functionalized cannabinoids.
An effective synthesis of tricyclic, nonclassical cannabinoids has been developed on the basis of a cation-olefin cyclization that forms the two nonaromatic rings with the desired stereochemistry in a single step.
Harrington
P E
PE
Department of Chemistry, University of Hawaii, Honolulu 96822, USA.
Stergiades
I A
IA
Erickson
J
J
Makriyannis
A
A
Tius
M A
MA
D000475:Alkenes; D000818:Animals; D001921:Brain / Q000378:metabolism; D002186:Cannabinoids / Q000138:chemical synthesis* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D007700:Kinetics; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013237:Stereoisomerism
D000475:Alkenes; D002186:Cannabinoids; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug