Glassy dynamics of protein folding.
A coarse-grained model of a random polypeptide chain, with only discrete torsional degrees of freedom and Hookean springs connecting pairs of hydrophobic residues is shown to display stretched exponential relaxation under Metropolis dynamics at low temperatures with the exponent beta approximately 1/4, in agreement with the best experimental results. The time dependent correlation functions for fluctuations about the native state, computed in the Gaussian approximation for real proteins, have also been found to have the same functional form. Our results indicate that the energy landscape exhibits universal features over a very large range of energies and is relatively independent of the specific dynamics.
Tüzel
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E
Department of Physics, Faculty of Sciences and Letters, Istanbul Technical University, Maslak 80626, Istanbul, Turkey.
Erzan
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A
D008956:Models, Chemical; D008958:Models, Molecular; D009010:Monte Carlo Method; D010455:Peptides / Q000737:chemistry*; D017510:Protein Folding; D013696:Temperature; D013816:Thermodynamics
D010455:Peptides