title: Completion pneumonectomy of the residual left lung to treat lung cancer in a patient with hemophilia A: report of a case.
abstract: Hemophilia A is a sex-linked recessive hereditary disease that is relatively rare and the number of patients with this disorder who undergo major surgery is limited. Although replenishing coagulation factors can allow hemophiliac patients to undergo similar surgery to that performed for patients without hemophilia, there have been few reports on major surgery and none on the resection of lung cancer in patients with hemophilia A. We recently performed completion pneumonectomy of the left lung in a 70-year-old man with hemophilia A, for squamous cell carcinoma in the residual left lung. The administration of a recombinant DNA coagulation factor VIII preparation allowed this operation to be successfully carried out. This case serves to demonstrate that the recombinant DNA coagulation factor VIII preparation described may enable us to safely perform major surgery on hemophiliac patients, since there is no risk of viral infection or any other adverse effects, such as deterioration of immunocompetence or hemolysis, which are occasionally encountered with human plasma-derived preparations.
authors.affiliation: Division of Thoracic Diseases, Chiba Cancer Center, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nomoto
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: N
authors.initials: N
authors.lastname: Iwai
authors.forename: T
authors.initials: T
authors.lastname: Mizobuchi
authors.forename: S
authors.initials: S
authors.lastname: Yokoi
authors.forename: K
authors.initials: K
authors.lastname: Kumagai
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005169:Factor VIII / Q000378:metabolism* / Q000627:therapeutic use*; D006467:Hemophilia A / Q000097:blood / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local; D019990:Perioperative Care; D011013:Pneumonectomy / Q000379:methods*; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; C078147:F8 protein, human; D005169:Factor VIII