title: Anorectal dysfunction in constipated women with anorexia nervosa.
abstract: OBJECTIVE
  To evaluate anorectal and colonic function in a group of patients with anorexia nervosa complaining of chronic constipation.
  
  
  METHODS
  Twelve women (age range, 19-29 years) meeting the criteria for anorexia nervosa and complaining of chronic constipation were recruited for the study. A group of 12 healthy women served as controls. Colonic transit time was measured by a radiopaque marker technique. Anorectal manometry and a test of rectal sensation were carried out with use of standard techniques to measure pelvic floor dysfunction. A subgroup of 8 patients was retested after an adequate refeeding program was completed.
  
  
  RESULTS
  Eight (66.7%) of 12 patients with anorexia nervosa had slow colonic transit times, while 5 (41.7%) had pelvic floor dysfunction. Colonic transit time normalized in the 8 patients who completed the 4-week refeeding program. However, pelvic floor dysfunction did not normalize in these patients.
  
  
  CONCLUSIONS
  Patients with anorexia nervosa who complain of constipation have anorectal motor abnormalities. Delayed colonic transit time is probably due to abnormal eating behavior.
authors.affiliation: Division of Gastroenterological Rehabilitation, Valeggio sul Mincio Hospital, University of Verona Medical School, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Chiarioni
authors.forename: G
authors.initials: G
authors.lastname: Bassotti
authors.forename: A
authors.initials: A
authors.lastname: Monsignori
authors.forename: M
authors.initials: M
authors.lastname: Menegotti
authors.forename: L
authors.initials: L
authors.lastname: Salandini
authors.forename: G
authors.initials: G
authors.lastname: Di Matteo
authors.forename: I
authors.initials: I
authors.lastname: Vantini
authors.forename: W E
authors.initials: WE
authors.lastname: Whitehead
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000503:physiopathology*; D000856:Anorexia Nervosa / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D002404:Catheterization / Q000295:instrumentation; D016009:Chi-Square Distribution; D002908:Chronic Disease; D003106:Colon / Q000503:physiopathology; D003248:Constipation / Q000150:complications / Q000503:physiopathology*; D003672:Defecation / Q000502:physiology; D005260:Female; D005502:Food; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D008365:Manometry / Q000295:instrumentation; D017773:Pelvic Floor / Q000503:physiopathology; D012007:Rectum / Q000503:physiopathology*; D012677:Sensation / Q000502:physiology; D018709:Statistics, Nonparametric; D014160:Transducers, Pressure