Degradation of bisphenol A by the lignin-degrading enzyme, manganese peroxidase, produced by the white-rot basidiomycete, Pleurotus ostreatus.
Degradation of 2,2-Bis(4-hydroxyphenyl)propane (bisphenol A, BPA), an endocrine-disturbing chemical, by the growing mycelia of the white-rot basidiomycete, Pleurotus ostreatus, was examined. About 80% of BPA initially present decreased in 12 days of culture with this fungus. By in vitro experiments using the lignin-degrading enzyme manganese peroxidase (MnP), BPA was metabolized to phenol, 4-isopropenylphenol, 4-isopropylphenol, and hexestrol. The degradation products of BPA were assumed to be formed by the one-electron oxidation of the substrate.
Hirano
T
T
Wood Research Institute, Kyoto University, Uji, Japan.
Honda
Y
Y
Watanabe
T
T
Kuwahara
M
M
D000395:Air Pollutants, Occupational / Q000493:pharmacokinetics; D001559:Benzhydryl Compounds; D001673:Biodegradation, Environmental; D008031:Lignin / Q000378:metabolism*; D010544:Peroxidases / Q000378:metabolism*; D010636:Phenols / Q000737:chemistry / Q000493:pharmacokinetics*; D020076:Pleurotus / Q000201:enzymology*; D000098826:Bisphenol A Compounds
D000395:Air Pollutants, Occupational; D001559:Benzhydryl Compounds; D008031:Lignin; D010544:Peroxidases; D010636:Phenols; C051129:manganese peroxidase; C006780:bisphenol A; D000098826:Bisphenol A Compounds