title: Methods for generating multivalent and bispecific antibody fragments.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
authors.forename: I
authors.initials: I
authors.lastname: Tomlinson
authors.forename: P
authors.initials: P
authors.lastname: Holliger
mesh_terms: D018033:Antibodies, Bispecific / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification; D000911:Antibodies, Monoclonal / Q000096:biosynthesis / Q000235:genetics / Q000302:isolation & purification; D000915:Antibody Affinity; D019677:Artificial Gene Fusion / Q000379:methods; D015153:Blotting, Western; D002846:Chromatography, Affinity / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007128:Immunoglobulin Fragments / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000235:genetics / Q000302:isolation & purification; D019151:Peptide Library; D010843:Pichia / Q000235:genetics; D015202:Protein Engineering / Q000379:methods; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000302:isolation & purification; D013205:Staphylococcal Protein A
chemical_list: D018033:Antibodies, Bispecific; D000911:Antibodies, Monoclonal; D007128:Immunoglobulin Fragments; D007074:Immunoglobulin G; D019151:Peptide Library; D011993:Recombinant Fusion Proteins; D013205:Staphylococcal Protein A