Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: pathologic and molecular studies.
We identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia.
Mircescu
H
H
Sainte-Justine Hospital, University of Montreal, Quebec, Canada.
Parma
J
J
Huot
C
C
Deal
C
C
Oligny
L L
LL
Vassart
G
G
Van Vliet
G
G
D002291:Carcinoma, Papillary; D002648:Child; D005260:Female; D006801:Humans; D009154:Mutation; D013964:Thyroid Neoplasms / Q000150:complications; D016606:Thyroid Nodule / Q000150:complications / Q000235:genetics* / Q000473:pathology