title: Indications for liver transplantation in British Columbia's Aboriginal population: a 10-year retrospective analysis.
abstract: OBJECTIVE
  To study the indications for liver transplantation among British Columbia's First Nation population.
  
  
  METHODS
  A retrospective analysis of the British Columbia Transplant Society's database of Aboriginal and non-Aboriginal liver transplant recipients from 1989 to 1998 was undertaken. For primary biliary cirrhosis (PBC), the transplant assessment database (patients with and without transplants) was analyzed using a binomial distribution and compared with published census data regarding British Columbia's proportion of Aboriginal people.
  
  
  RESULTS
  Between 1989 and 1998, 203 transplantations were performed in 189 recipients. Fifteen recipients were Aboriginal (n=15; 7.9%). Among all recipients, the four most frequent indications for liver transplantation were hepatitis C virus (HCV) infection (n=57; 30.2%), PBC (n=34; 18.0%), alcohol (n=22; 11.6%) and autoimmune hepatitis (n=14; 7.4%). Indications for liver transplantation among Aboriginal people were PBC (n=8; 53.3%; P<0.001 compared with non-Aboriginal people), autoimmune hepatitis (n=4; 26.67%; P=0.017), acute failure (n=2; 13.3%) and HCV (n=1). Among all patients referred for liver transplantation with PBC (n=43), 29 (67.44%) were white and 11 (25.6%) were Aboriginal. A significant difference was found between the proportion of Aboriginal people referred for liver transplantation and the proportion of Aboriginal people in British Columbia (139,655 of 3,698,755 [3.8%]; 1996 Census, Statistics Canada) (P<0.001).
  
  
  CONCLUSIONS
  Aboriginal people in British Columbia are more likely to be referred for liver transplantation with a diagnosis of PBC but are less likely to receive a liver transplant because of HCV or alcohol than are non-Aboriginal people.
authors.affiliation: Department of Medicine, The University of British Columbia, Vancouver, British Columbia.
authors.forename: E M
authors.initials: EM
authors.lastname: Yoshida
authors.forename: N R
authors.initials: NR
authors.lastname: Caron
authors.forename: A K
authors.initials: AK
authors.lastname: Buczkowski
authors.forename: L T
authors.initials: LT
authors.lastname: Arbour
authors.forename: C H
authors.initials: CH
authors.lastname: Scudamore
authors.forename: U P
authors.initials: UP
authors.lastname: Steinbrecher
authors.forename: S R
authors.initials: SR
authors.lastname: Erb
authors.forename: S W
authors.initials: SW
authors.lastname: Chung
mesh_terms: D001955:British Columbia / Q000208:ethnology; D016208:Databases, Factual; D006526:Hepatitis C / Q000208:ethnology / Q000601:surgery; D019693:Hepatitis, Autoimmune / Q000208:ethnology / Q000601:surgery; D006801:Humans; D007198:Indians, North American; D008104:Liver Cirrhosis, Alcoholic / Q000208:ethnology / Q000601:surgery; D008105:Liver Cirrhosis, Biliary / Q000208:ethnology / Q000601:surgery; D016031:Liver Transplantation / Q000706:statistics & numerical data; D018579:Patient Selection; D012189:Retrospective Studies; D044465:White People