Muscle glucose transporter (GLUT 4) gene expression during exercise.
Among the many effects of exercise is the induction of glucose transporter (GLUT 4) expression in skeletal muscle. In this review, we examine the intracellular signals that may mediate the exercise-induced increase in GLUT4 gene transcription. This induction is likely to be dependent upon intracellular calcium concentrations and the energy charge of the muscle.
MacLean
P S
PS
Department of Biochemistry, School of Medicine, East Carolina University, Greenville, North Carolina 27858, USA.
Zheng
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Dohm
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GL
D055372:AMP-Activated Protein Kinases; D000818:Animals; D019703:Calcineurin / Q000378:metabolism / Q000502:physiology; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D002147:Calmodulin / Q000378:metabolism / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology*; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D064326:MEF2 Transcription Factors; D051379:Mice; D008822:Mice, Transgenic; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D009097:Multienzyme Complexes / Q000378:metabolism; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism* / Q000502:physiology; D018006:Myogenic Regulatory Factors; D011493:Protein Kinase C / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D015398:Signal Transduction; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D002147:Calmodulin; D004268:DNA-Binding Proteins; D064326:MEF2 Transcription Factors; D009004:Monosaccharide Transport Proteins; D009097:Multienzyme Complexes; D018006:Myogenic Regulatory Factors; D012333:RNA, Messenger; D014157:Transcription Factors; D017346:Protein Serine-Threonine Kinases; D011493:Protein Kinase C; D055372:AMP-Activated Protein Kinases; D019703:Calcineurin; D005947:Glucose; D002118:Calcium