Bombesin improves burn-induced intestinal injury in the rat.
This study was designed to determine the effect of exogenous bombesin (10 microg/kg/day, subcutaneously, three times a day) on intestinal hypomotility and neutrophil infiltration in the early and late phases of burn injury (partial-thickness, second-degree burn of the skin). In acute (2 h after burn injury) or chronic (3 days after) burn groups, intestinal transit was delayed, which was reversed by bombesin treatment. In the acute burn group, but not in the chronic group, increased MPO activity was also reduced by bombesin treatment. The results demonstrate that bombesin ameliorates the intestinal inflammation due to burn injury, involving a neutrophil-dependent mechanism.
Alican
I
I
Department of Physiology, Marmara University, School of Medicine, 81326 Haydarpaşa-, Istanbul, Turkey.
Unlüer
E E
EE
Yeğen
C
C
Yeğen
B C
BC
D000818:Animals; D001839:Bombesin / Q000494:pharmacology* / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy*; D005260:Female; D007422:Intestines / Q000293:injuries*; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D009195:Peroxidase; D001839:Bombesin