Photochemical and photobiological properties of new bispsoralen derivatives (Bis[PsCn]PIP, n = 4, 6, 8).
Bispsoralen derivatives possessing two psoralens and one piperazine molecule, 1,4-bis[n'-(8-psoralenoxy) alkyl] piperazine (Bis[PsCn]PIP, n = 4, 6, 8), show high water solubility, efficient intercalation into DNA and good photocrosslinking efficiency of DNA. Bis(PsC4)PIP shows high lethality on bacteriophage T7 and can effectively inhibit the amplification of DNA by stopping the polymerase chain reactions in a short period of irradiation time.
Kim
S K
SK
Department of Chemistry, School of Molecular Science and Center for Molecular Design and Synthesis, Korea Advanced Institute of Science and Technology, Taejon, South Korea.
Park
H O
HO
Shim
S C
SC
D000818:Animals; D017123:Bacteriophage T7 / Q000187:drug effects; D002417:Cattle; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D011564:Furocoumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018462:Photobiology; D010777:Photochemistry; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D003432:Cross-Linking Reagents; D011564:Furocoumarins; D007364:Intercalating Agents; D010879:Piperazines; D011838:Radiation-Sensitizing Agents; D004247:DNA