title: Granulosa cell tumor of the adult type: a case report and review of the literature of a very rare testicular tumor.
abstract: We report a case of testicular granulosa cell tumor of the adult type in a 48-year-old man. Microscopically, the tumor consisted of round to ovoid cells with grooved nuclei that were arranged in several patterns, including microfollicular, macrofollicular, insular, trabecular, gyriform, solid, and pseudosarcomatous. These cells demonstrated strong immunopositivity with MIC2 (O13) antibody, vimentin, and smooth muscle actin and focal positivity with cytokeratin. Although this type of sex cord-stromal tumor is relatively common in the ovaries, it is still extremely unusual in the testis, and it probably represents the rarest type of testicular sex cord-stromal tumor.
authors.affiliation: Departments of Pathology, College of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia.
authors.forename: I A
authors.initials: IA
authors.lastname: Al-Bozom
authors.forename: S R
authors.initials: SR
authors.lastname: El-Faqih
authors.forename: S H
authors.initials: SH
authors.lastname: Hassan
authors.forename: A E
authors.initials: AE
authors.lastname: El-Tiraifi
authors.forename: R F
authors.initials: RF
authors.lastname: Talic
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D006106:Granulosa Cell Tumor / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D013736:Testicular Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins