The distribution of the neurokinin B receptor in the human and rat hypothalamus.
The neurokinin B receptor (NK3) is an element of the hypothalamic neuronal circuitry regulating blood pressure in rats. The present study used immunohistochemistry to reveal the distribution of NK3 in the human hypothalamus. The strongest NK3-like immunoreactivity in the human hypothalamus was found in neurons of the paraventricular nucleus, specifically in the parvicellular and posterior paraventricular subnuclei. Another prominent population of NK3-positive cells in the human hypothalamus was found in the perifornical nucleus. The present study also showed two previously unreported populations of NK3-positive neurons in the rat periventricular nucleus and medial magnocellular paraventricular subnucleus. It is concluded that there is a large degree of similarity in the distribution of NK3 in the human and rat hypothalamus.
Koutcherov
Y
Y
School of Psychology, The University of New South Wales, Sydney, Australia.
Ashwell
K W
KW
Paxinos
G
G
D000328:Adult; D000368:Aged; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D005260:Female; D020712:Fornix, Brain / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008297:Male; D015287:Neurokinin B / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D018042:Receptors, Neurokinin-3 / Q000378:metabolism*
D018042:Receptors, Neurokinin-3; D015287:Neurokinin B