The Toll receptor family and microbial recognition.
The survival of multicellular organisms is dependent on their ability to recognize invading microbial pathogens and to induce a variety of defense reactions. Recent evidence suggests that an evolutionarily ancient family of Toll-like receptors plays a crucial role in the detection of microbial infection and the induction of immune and inflammatory responses.
Medzhitov
R
R
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. ruslan@yale.edu
Janeway
C
C
D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D004330:Drosophila / Q000276:immunology; D029721:Drosophila Proteins; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology* / Q000382:microbiology; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; C495341:tehao protein, Drosophila