title: Transthoracic Doppler echocardiographic comparison of left internal mammary grafts to left anterior descending coronary artery with ungrafted right internal mammary arteries in patients with and without myocardial ischemia by dobutamine stress echocardiography.
abstract: To characterize Doppler flow patterns of the grafted left internal mammary artery (LIMA) in patients with and without dobutamine stress induced wall motion abnormalities in the graft distribution, we studied 29 patients who underwent coronary artery bypass surgery using LIMA grafts to the left anterior descending coronary artery (LAD). The ungrafted right internal mammary artery (RIMA) was used as a control. RIMA Doppler flow pattern was predominantly systolic in all patients. In patients without ischemia in the LAD distribution, LIMA flow was predominantly diastolic. In patients with ischemia, LIMA flow was predominantly systolic. In the grafted LIMA, a ratio of diastolic to systolic time-velocity integral of > 1.5 best showed absence of ischemia in the graft distribution. In summary, characterization of the Doppler flow pattern in the internal mammary arteries is feasible. In the grafted LIMA, ratios of diastolic to systolic flow are less in patients with an ischemic response in the subtended vascular bed than in those without ischemia.
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Arruda
authors.forename: P A
authors.initials: PA
authors.lastname: Pellikka
authors.forename: D W
authors.initials: DW
authors.lastname: Mahoney
authors.forename: A
authors.initials: A
authors.lastname: Joseph
authors.forename: W
authors.initials: W
authors.lastname: Mathias
authors.forename: J B
authors.initials: JB
authors.lastname: Seward
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001026:Coronary Artery Bypass / Q000379:methods*; D003331:Coronary Vessels / Q000503:physiopathology / Q000601:surgery; D004280:Dobutamine; D004452:Echocardiography / Q000379:methods*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008323:Mammary Arteries / Q000000981:diagnostic imaging* / Q000637:transplantation*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery*; D011336:Probability; D012016:Reference Values; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D014654:Vascular Patency
chemical_list: D004280:Dobutamine