title: Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C.
abstract: Nuclear events of mitosis are initiated when the protein kinase cyclin-B1-Cdk1 is translocated into the nucleus during prophase. Recent work has unveiled many of the mechanisms that govern the localization of cyclin-B1-Cdk1 and its regulator Cdc25C. Phosphorylation-dependent changes in the rate of nuclear import and export of these proteins help to control the onset of mitosis both in normal cells and in cells delayed before mitosis by DNA damage.
authors.affiliation: Department of Physiology, University of California, San Francisco, CA 94143-0444, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Takizawa
authors.forename: D O
authors.initials: DO
authors.lastname: Morgan
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D019926:Cyclin B / Q000378:metabolism*; D056744:Cyclin B1; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D004249:DNA Damage / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D011418:Prophase / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D014981:Xenopus; D020687:cdc25 Phosphatases / Q000378:metabolism*
chemical_list: C534699:CCNB1 protein, human; D018797:Cell Cycle Proteins; D019926:Cyclin B; D056744:Cyclin B1; D018844:Cyclin-Dependent Kinases; C517009:CDC25C protein, human; D020687:cdc25 Phosphatases