title: Gestational surrogacy: a feasible option for patients with Rokitansky syndrome.
abstract: Rokitansky syndrome is a developmental defect characterized by agenesis of the uterus and vagina but normal gonads and secondary sexual characters. It is not commonly transmitted as a dominant genetic trait. Surrogacy, which is legally and ethically accepted in the UK and other countries, has made it possible for the patients with this syndrome to have their own genetic children. Six patients with Rokitansky syndrome underwent 11 ovarian stimulation cycles that resulted in 11 fresh and three frozen embryo transfer procedures into six prospective surrogate mothers. Both commissioning and surrogate couples were properly screened and counselled and their treatment was approved by the clinic internal review committee (ethics committee). The treatment cycles resulted in six clinical pregnancies (42.9% pregnancy rate per embryo transfer and 54.5% per oocyte retrieval) and three live births (21. 4% per embryo transfer, 27.3% per retrieval and 50% per patient). Gestational surrogacy is a viable treatment for patients with Rokitansky syndrome. Such patients should be well informed and supported to be able to have a family using their own genetic gametes.
authors.affiliation: Chelsea and Westminster Hospital, London SW10 9NH, London Gynaecology and Fertility Centre, 112A Harley Street, London W1N 1AF and Queen Charlotte and Chelsea Hospital, London W6 0XG, UK.
authors.forename: S
authors.initials: S
authors.lastname: Beski
authors.forename: A
authors.initials: A
authors.lastname: Gorgy
authors.forename: G
authors.initials: G
authors.lastname: Venkat
authors.forename: I L
authors.initials: IL
authors.lastname: Craft
authors.forename: K
authors.initials: K
authors.lastname: Edmonds
mesh_terms: D000015:Abnormalities, Multiple / Q000503:physiopathology; D000328:Adult; D001723:Birth Rate; D004624:Embryo Transfer; D005240:Feasibility Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013533:Gestational Carriers; D013577:Syndrome; D014599:Uterus / Q000002:abnormalities*; D014621:Vagina / Q000002:abnormalities*