Anti-striatal antibodies in Tourette syndrome cause neuronal dysfunction.
Serologic studies of children with Tourette syndrome (TS) have detected anti-neuronal antibodies but their role in TS has not been explored. Stereotypies and episodic utterances, analogous to involuntary movements seen in TS, were induced in rats by intrastriatal microinfusion of TS sera or gamma immunoglobulins (IgG) under noninflammatory conditions, as found in TS. Immunohistochemical analysis confirmed the presence of IgG selectively bound to striatal neurons. These data support the hypothesis that binding of an anti-neuronal antibody from some children with TS induced striatal dysfunction and suggest a possible cause for the basal ganglia alterations observed in children with TS.
Hallett
J J
JJ
Department of Pediatrics, Brown University School of Medicine and 111 Brewster Street, 02860, Pawtucket, RI, USA. joseph_hallet@brown.edu
Harling-Berg
C J
CJ
Knopf
P M
PM
Stopa
E G
EG
Kiessling
L S
LS
D000293:Adolescent; D000818:Animals; D001323:Autoantibodies / Q000494:pharmacology; D001522:Behavior, Animal; D002648:Child; D003342:Corpus Striatum / Q000166:cytology / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007074:Immunoglobulin G / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000276:immunology*; D051381:Rats; D011916:Rats, Inbred F344; D013239:Stereotyped Behavior; D005879:Tourette Syndrome / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G