p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia.
p53 codon 72 polymorphism was analysed in UK women with human papillomavirus (HPV)-associated vulval intraepithelial neoplasia and vulval squamous cell carcinoma. Arginine homozygotes were significantly less common in either group compared with controls. We conclude that the arginine polymorphism may confer protection against the development of HPV-associated vulval neoplasia.
Rosenthal
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Department of Gynaecological Oncology, Academic Department of Histopathology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, West Smithfield, London, EC1A 7BE, UK.
Ryan
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A
Hopster
D
D
Jacobs
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IJ
D000328:Adult; D001120:Arginine / Q000737:chemistry; D002278:Carcinoma in Situ / Q000209:etiology / Q000235:genetics* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000235:genetics* / Q000821:virology; D003062:Codon / Q000235:genetics; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications*; D011110:Polymorphism, Genetic; D014412:Tumor Virus Infections / Q000150:complications*; D014846:Vulvar Neoplasms / Q000209:etiology / Q000235:genetics* / Q000821:virology
D003062:Codon; D001120:Arginine