title: [Interaction of Ag+ ions with DNA and its monomers].
abstract: Differential UV spectra of DNA and its monomers that were induced by Ag+ ions were measured, and the effect of ions on the parameters of the helix-coil transition was studied. The data obtained confirm the existence of "strong" and "weak" modes of binding of Ag+ to DNA. The earlier proposed proton transfer from N1G to N3C, which is determined by the interaction of Ag+ with N7G (a "strong" complex), follows immediately from the shape of the differential UV spectra. The positive cooperativity of the binding of Ag+ to DNA upon the formation of a "weak" complex is due to the cooperativity of the transition of DNA to a new double-helical conformation. A model of this conformation is proposed which suggests the formation of Hougsteen GC and AT pairs.
authors.affiliation: Verkin Physicotechnical Institute of Low Temperatures, National Academy of Sciences of Ukaine, Kharkov, Ukraine.
authors.forename: V A
authors.initials: VA
authors.lastname: Sorokin
authors.forename: V A
authors.initials: VA
authors.lastname: Valeev
authors.forename: G O
authors.initials: GO
authors.lastname: Gladchenko
authors.forename: I V
authors.initials: IV
authors.lastname: Sysa
authors.forename: I V
authors.initials: IV
authors.lastname: Volchok
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Blagoĭ
mesh_terms: D002414:Cations, Monovalent; D004247:DNA / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002414:Cations, Monovalent; D012834:Silver; D004247:DNA