title: Thrombin-induced platelet microbicidal protein susceptibility phenotype influences the outcome of oxacillin prophylaxis and therapy of experimental Staphylococcus aureus endocarditis.
abstract: We previously showed that in vitro susceptibility profiles of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 (tPMP-1) impacted the outcome of vancomycin treatment in experimental infective endocarditis. In this same model, treatment with oxacillin (a more rapid staphylocidal agent than vancomycin) enhanced the clearance of both tPMP-1-susceptible and -resistant cells from vegetations. The extent of clearance was greater for tPMP-1-susceptible cells.
authors.affiliation: Division of Infectious Diseases, Charles Drew University-Martin Luther King Medical Center, Los Angeles, California 90059, USA. vidhawan@cdrewu.edu
authors.forename: V K
authors.initials: VK
authors.lastname: Dhawan
authors.forename: A S
authors.initials: AS
authors.lastname: Bayer
authors.forename: M R
authors.initials: MR
authors.lastname: Yeaman
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001798:Blood Proteins / Q000494:pharmacology*; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000517:prevention & control*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D010641:Phenotype; D011817:Rabbits; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013211:Staphylococcus aureus / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001798:Blood Proteins; D010406:Penicillins; C077150:platelet microbicidal protein, Oryctolagus cuniculus; D010068:Oxacillin