title: Noninvasive assessment of cardiac risk in type I diabetic patients being evaluated for combined pancreas-kidney transplantation using dipyridamole-MIBI perfusion tomographic scintigraphy.
abstract: This study was performed to determine the value of dipyridamole-99m Tc-methoxy-isobutyl isonitrile perfusion (99mTC-MIBI) tomographic scintigraphy in the assessment of cardiac risk in patients being evaluated prior to combined pancreas-kidney transplantation (PKT). We performed perfusion tomographic scintigraphy using single photon emission computed tomography (SPECT) on 77 patients. The tomographic images did not show clinically relevant findings in 65 patients. In the remaining 12 patients, coronary arteriography was performed: 2 showed normal results, 4 showed no stenosis, and 6 showed significant stenosis ( > or = 70%). Seventy-two patients underwent PKT. During the follow-up (6-48 months), there were seven cardiac events, 4 patients with significant stenosis, and 3 with nonsignificant stenosis upon coronary arteriography, and all had pathological tomographic images. 99mTc-MIBI tomographic scintigraphy may be useful in identifying patients at low risk of incurring cardiac events after PKT and may, in a large group of patients, obviate the need for routine coronary angiography.
authors.affiliation: Department of Nuclear Medicine Department, Hospital Clínic of Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Fuster
authors.forename: J
authors.initials: J
authors.lastname: Magriñá
authors.forename: M J
authors.initials: MJ
authors.lastname: Ricart
authors.forename: J
authors.initials: J
authors.lastname: Pascual
authors.forename: C
authors.initials: C
authors.lastname: Laterza
authors.forename: F J
authors.initials: FJ
authors.lastname: Setoain
authors.forename: S
authors.initials: S
authors.lastname: Vidal-Sicart
authors.forename: J J
authors.initials: JJ
authors.lastname: Mateos
authors.forename: F
authors.initials: F
authors.lastname: Martín
authors.forename: A
authors.initials: A
authors.lastname: Muxí
mesh_terms: D000328:Adult; D000075202:Contraindications; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery; D004176:Dipyridamole; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000187:drug effects; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000517:prevention & control*; D019275:Radiopharmaceuticals; D018570:Risk Assessment; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents
chemical_list: D019275:Radiopharmaceuticals; D014665:Vasodilator Agents; D004176:Dipyridamole; D017256:Technetium Tc 99m Sestamibi