title: Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: D J
authors.initials: DJ
authors.lastname: Underwood
authors.forename: M A
authors.initials: MA
authors.lastname: Cascieri
authors.forename: S P
authors.initials: SP
authors.lastname: Rohrer
authors.forename: L D
authors.initials: LD
authors.lastname: Cantin
authors.forename: G
authors.initials: G
authors.lastname: Chicchi
authors.forename: A B
authors.initials: AB
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Hirschmann
mesh_terms: D000818:Animals; D016466:CHO Cells; D019556:COS Cells; D006224:Cricetinae; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008565:Membrane Proteins; D018716:Molecular Mimicry; D064729:Neurokinin-1 Receptor Antagonists; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013004:Somatostatin / Q000819:agonists / Q000737:chemistry*; D013373:Substance P / Q000037:antagonists & inhibitors*
chemical_list: D005960:Glucosides; D008565:Membrane Proteins; D064729:Neurokinin-1 Receptor Antagonists; D018040:Receptors, Neurokinin-1; D017481:Receptors, Somatostatin; C098681:somatostatin receptor subtype-4; D013373:Substance P; D013004:Somatostatin