Urinary prostaglandin excretion in pregnancy: the effect of dietary sodium restriction.
BACKGROUND
Dietary sodium restriction results in activation of the renin-angiotensin-aldosterone-system. In the non-pregnant situation renin release in response to a low sodium diet is mediated by prostaglandins. We studied the effect of dietary sodium restriction on urinary prostaglandin metabolism in pregnancy.


METHODS
In a randomized, longitudinal study the excretion of urinary metabolites of prostacyclin (6-keto-PGF(1 alpha)and 2,3-dinor-6-keto-PGF(1 alpha)) and thromboxane A(2)(TxB(2)and 2,3-dinor-TxB(2)) was determined throughout pregnancy and post partum in 12 women on a low sodium diet and in 12 controls.


RESULTS
In pregnancy the excretion of all urinary prostaglandins is increased. The 6-keto-PGF(1 alpha)/ TxB(2)-ratio as well as the 2, 3-dinor-6-keto-PGF(1 alpha)/ 2,3-dinor-TxB(2)-ratio did not significantly change in pregnancy. CONCLUISION Prostacyclin and thromboxane do not seem to play an important role in sodium balance during pregnancy.
Delemarre
F M
FM
Department of Obstetrics and Gynecology, University Medical Center Nijmegen, The Netherlands. f.delemarre@obgyn.azn.nl
Thomas
C M
CM
van den Berg
R J
RJ
Jongsma
H W
HW
Steegers
E A
EA
D015121:6-Ketoprostaglandin F1 alpha / Q000031:analogs & derivatives / Q000652:urine; D000328:Adult; D003404:Creatinine / Q000652:urine; D004039:Diet, Sodium-Restricted; D011464:Epoprostenol / Q000652:urine; D005260:Female; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000378:metabolism / Q000652:urine; D008137:Longitudinal Studies; D049590:Postpartum Period; D011247:Pregnancy / Q000378:metabolism* / Q000652:urine*; D011453:Prostaglandins / Q000378:metabolism / Q000652:urine*; D011897:Random Allocation; D012964:Sodium / Q000652:urine; D013928:Thromboxane A2 / Q000378:metabolism; D013929:Thromboxane B2 / Q000031:analogs & derivatives / Q000652:urine; D014882:Water-Electrolyte Balance
D011453:Prostaglandins; D013929:Thromboxane B2; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; C028965:2,3-dinor-thromboxane B2; C028290:2,3-dinor-6-ketoprostaglandin F1alpha; D012964:Sodium; D003404:Creatinine; D011464:Epoprostenol