title: Gastroesophageal reflux, allergy and chronic tubotympanal disorders in children.
abstract: The purpose of this study is to examine the relation between gastroesophageal reflux and allergy as possible causes of chronic tubotympanal pathology. The 30 examined children (ages 2-13) were divided into two groups based on the otological criteria. The 16 examined children suffered from a secretory otitis, which lasted more than four months. Upon further examination with a microscope, seven of these children exhibited symptoms of the adhesive process of the middle ear. Furthermore, 14 patients suffered from a recurrent otitis, i.e. more than five cases of otitis per year, while five patients from this group suffered from a chronic otitis with a central defect of the tympanum. The method used for the examination of the gastroesophageal reflux consisted of a continual 24 h esophageal pH monitoring. The particular apparatus used for this included antimony electrode (Synetics Medical, Sweden), while the analysis we performed was processed through the PC software program Gastrosoft Inc. The reflux index higher than five was considered pathological. At the time of the gastroesophageal reflux examination, we also performed the allergological analysis. The presence of allergy was confirmed by three methods: the positive allergological anamnesis, the positive skin pick test and by the elevated quantities of specific IgEs (Pharmacia CAP system). The examination resulted in the following: 18 of the examined children suffered from the pathological gastroesophageal reflux (60%); further seven of our patients tested positive on the allergological test (23%); and the four who tested positive for allergy also suffered from the pathological gastroesophageal reflux (13%). In comparison with allergies, the pathological GER was substantially more frequent in the patients who suffered from chronic tubotympanal disorders.
authors.affiliation: Clinic of Otorhinolaryngology, Rijeka University Medical School, Kresimirova 42, 51000, Rijeka, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Velepic
authors.forename: V
authors.initials: V
authors.lastname: Rozmanic
authors.forename: M
authors.initials: M
authors.lastname: Velepic
authors.forename: M
authors.initials: M
authors.lastname: Bonifacic
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D015897:Comorbidity; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D010034:Otitis Media with Effusion / Q000175:diagnosis / Q000453:epidemiology*; D010035:Otitis Media, Suppurative / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011336:Probability; D015203:Reproducibility of Results; D012307:Risk Factors