[The effects of diltiazem on pulmonary hemodynamics and oxygenation in copd induced pulmonary hypertension].
OBJECTIVE
To study hemodynamic the effects of intravenous diltiazem on COPD induced pulmonary hypertention.


METHODS
11 cases in exacerbation stage were chosen to study. Swan-Ganz catheterization were taken for hemodynamic monitoring.


RESULTS
After the administration of diltiazem, pulmonary vascular resistance, pulmonary pressure, right artrial pressure and heart rate decreased significantly (the extents decreased were 14.0 kPa.s-1.L-1, 0.62-1.27 kPa, 0.27-0.40 kPa and 25-30 beats/min respectively, P < 0.05); Cardiac output and stroke volume increased identically (the extents increased were 0.3-0.6 L.min-1.m-2 and 5-9 ml.beat-1.m-2 respectively, P < 0.05); No significant changes found in Qs/Qt, PaO2 and systemic blood pressure.


CONCLUSIONS
Our study showed that diltiazem produces beneficial pulmonary hemodynamic effects without oxygenation compromise in COPD cases and has a strong indication in those who complicated with superventricular tachycardia.
Fang
B
B
Deportment of Respiratory, Beijing Red Cross Chaoyang Hospital, Capital University of Medical Sciences.
Wang
C
C
Dai
H
H
D000368:Aged; D004110:Diltiazem / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D011651:Pulmonary Artery / Q000503:physiopathology; D014665:Vasodilator Agents / Q000627:therapeutic use
D014665:Vasodilator Agents; D004110:Diltiazem