title: Acute granulomatous interstitial nephritis and colitis in anticonvulsant hypersensitivity syndrome associated with lamotrigine treatment.
abstract: We present the case of a 17-year-old woman with a history of bipolar disorder, who developed a clinical syndrome manifested by fever, lymphadenopathy, skin rash, diarrhea, and acute renal failure requiring dialysis after the use of lamotrigine. Renal biopsy showed acute interstitial nephritis (AIN) with focal granulomas. Similarly, colonic biopsy specimens showed colitis and ileitis with non-necrotizing epithelioid granulomas. The patient had a complete recovery after withdrawal of the medication and steroid treatment. Although lamotrigine has been previously implicated in the development of anticonvulsant hypersensitivity syndrome, there have been no previous reports of acute granulomatous interstitial nephritis or colitis associated with the use of this drug.
authors.affiliation: Division of Nephrology, Baylor University Medical Center, Dallas, TX, USA. fervenza.fernando@mayo.edu
authors.forename: F C
authors.initials: FC
authors.lastname: Fervenza
authors.forename: S
authors.initials: S
authors.lastname: Kanakiriya
authors.forename: R T
authors.initials: RT
authors.lastname: Kunau
authors.forename: R
authors.initials: R
authors.lastname: Gibney
authors.forename: D J
authors.initials: DJ
authors.lastname: Lager
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D005260:Female; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D000077213:Lamotrigine; D008775:Methylprednisolone / Q000627:therapeutic use; D009102:Multiple Organ Failure / Q000139:chemically induced*; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D014227:Triazines / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D000928:Antidepressive Agents; D014227:Triazines; D000077213:Lamotrigine; D008775:Methylprednisolone