Avascular necrosis of head of femur in a patient with acute promyelocytic leukemia.
Avascular necrosis (AVN) of head of the femur is associated with various pathological conditions and treatment modalities. We present a case of acute promyelocytic leukemia who was treated with all-transretinoic acid (ATRA), daunomycin, cytarabine and a short course of dexamethasone. He developed AVN of bone after 2 years of treatment. Whether this is related to ATRA is dealt with in the discussion.
Abhyankar
D
D
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.
Nair
R
R
Menon
H
H
Kapoor
B
B
Advani
S
S
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D005271:Femur Head Necrosis / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*
D003561:Cytarabine; D014212:Tretinoin; D003907:Dexamethasone; D003630:Daunorubicin