Synthesis and in vitro cytotoxicity of 2-alkylaminosubstituted quinoline derivatives.
Eight 2-alkylaminosubstituted 5,8-dimethoxy-4-methylquinolines and nine 2-alkylaminosubstituted or 2,6-disubstituted 4-methylquinoline-5,8-diones were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, HCT15 and SF295).
Lee
H
H
College of Pharmacy, Chungbuk National University, Cheongju, Korea. medchem@trut.chungbuk.ac.kr
Lee
J
J
Hong
S S
SS
Yang
S I
SI
Jung
S H
SH
Jahng
Y
Y
Cho
J
J
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011804:Quinolines