title: [Management of adverse drug effects].
abstract: Adverse drug reactions (ADRs) are still considered one of the main problems of drug therapy. ADRs are associated with considerable morbidity, mortality, decreased compliance and therapeutic success as well as high direct and indirect medical costs. Several considerations have to come into play when managing a potential ADR. It is critical to establish an accurate clinical diagnosis of the adverse event. Combining information about drug exposure together with considering other possible causes of the reaction is crucial to establish a causal relationship between the reaction and the suspected drug. Identification of the underlying pathogenesis of an ADR together with the severity of the reaction will have profound implications on continuation of drug therapy after an ADR. Since spontaneous reports about ADRs are a key stone of a functioning post-marketing surveillance system and therefore play a key role in improving drug safety, health care professionals are highly encouraged to report ADRs to a local or national organization. However, because the majority of ADRs is dose-dependent and therefore preventable, individualization of pharmacotherapy may have a major impact on reducing such events.
authors.affiliation: Abteilung Klinische Pharmakologie, Kantonsspital Basel. schliengerr@uhbs.ch
authors.forename: R G
authors.initials: RG
authors.lastname: Schlienger
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control*; D005858:Germany; D006801:Humans