title: Epidemiology of Reye's syndrome, United States, 1991-1994: comparison of CDC surveillance and hospital admission data.
abstract: This investigation describes the epidemiology of Reye's syndrome (RS) during 1991-1994 and compares two different sources of information in the United States. Estimates of the incidence of RS from the Centers for Disease Control and Prevention (CDC) are compared with hospital inpatient data from approximately one third of the hospitals from HCIA, Inc. During 1991-1994, 48 RS cases were reported to the CDC and 93 RS hospitalizations based on HCIA data. When the HCIA data are extrapolated to the US population, there were an estimated 284 hospitalizations. Cases reported from both data sources were similar in distribution by onset, age, and sex. CDC data probably underestimate the incidence of RS due to incomplete reporting and HCIA data may overestimate it because not all cases were known to meet the CDC case definition. The true annual incidence of RS during the study years was probably between 0.2 and 1.1 cases per million population <18 years of age.
authors.affiliation: School of Medicine and Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. cdckms@sph.emory.edu
authors.forename: K M
authors.initials: KM
authors.lastname: Sullivan
authors.forename: E D
authors.initials: ED
authors.lastname: Belay
authors.forename: R E
authors.initials: RE
authors.lastname: Durbin
authors.forename: D A
authors.initials: DA
authors.lastname: Foster
authors.forename: D F
authors.initials: DF
authors.lastname: Nordenberg
mesh_terms: D000293:Adolescent; D002487:Centers for Disease Control and Prevention, U.S.; D002648:Child; D002675:Child, Preschool; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D010343:Patient Admission / Q000706:statistics & numerical data*; D011159:Population Surveillance; D012189:Retrospective Studies; D012202:Reye Syndrome / Q000401:mortality* / Q000534:rehabilitation*; D015996:Survival Rate; D014481:United States / Q000453:epidemiology