[The growth-inhibiting effects of hyperthermic-hypoosmotic solution alone and in combination with chemotherapeutic agents on human gastric cancer xenograft in mice].
OBJECTIVE
To evaluate the efficacy of hyperthermic-hypoosmotic solution alone and in combination with anti-tumor drugs in the growth inhibition of human gastric cancer xenografts in immuno-compromised Balb/c mice.


METHODS
Cyclosporin A-treated mice bearing human gastric cancer Sy86B in the peritoneal cavity were treated i.p. twice with 43 degrees C double distilled water (DDW) or 43 degrees C DDW containing 0.05% chlorhexidine or 43 degrees C DDW with carboplatin(10 mg/kg). Normal saline at ambient temperature injected i.p. was used as control.


RESULTS
Compared with the control, in mice treated with 43 degrees C alone or in combination with one of the two chemotherapeutic agents, significantly better therapeutic effects were obtained as shown by a decrease in tumor cell Brdu labeling index (BLI), proliferation index (PI) and DNA index (DI), prolongation of survival period and reduction of CEA and hEGF contents in the peritoneal effusion. The best treatment result was observed in mice receiving carboplatin in 43 degrees C DDW which was also superior to that in mice treated with carboplatin alone.


CONCLUSIONS
Hyperthermic-hypoosmotic solution containing chemotherapeutic agent by i.p. infusion may be a treatment of choice in the management of peritoneal carcinomatosis in advanced stomach cancer patients.
Xu
H
H
Cancer Institute, China Medical University, Shenyang.
Chen
J
J
He
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage*; D002710:Chlorhexidine / Q000008:administration & dosage*; D006358:Hot Temperature; D006801:Humans; D007038:Hypotonic Solutions / Q000008:administration & dosage; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007038:Hypotonic Solutions; D016190:Carboplatin; D002710:Chlorhexidine