Muscle and serum changes with salbutamol administration in aerobically exercised rats.
Treatment of experimental animals subjected to 90 days physical training programme plus repeated doses of salbutamol, a beta-adrenergic agonist, administered under two different regimes: therapeutic (16 microg/kg body weight, twice a day) and doping (3 mg/kg body weight, twice a day), caused a marked increase in size of skeletal (soleus, gastrocnemius and plantaris) leg muscles. Adrenergic involvement of salbutamol-linked hypertrophy was demonstrated by co-administration of the non-specific beta-adrenergic antagonist D,L-propranolol (10 mg/kg body weight twice a day). The salbutamol-induced muscle hypertrophy was associated with an early increase in creatine phosphokinase (CK) and its myocardial isozyme (CKmb), without significant changes in lactate dehydrogenase (LDH), alanine aminotransferase (AAT) and aspartate aminotransferase (DAT). The induction of muscle-injury biomarkers was completely abolished by co-administration of propranolol, thus suggesting the adrenergic involvement of these alterations.
Cepero
M
M
Departamento de Farmacología y Toxicología, Universidad de León, Spain.
Pérez-Pertejo
Y
Y
Cubría
J C
JC
Reguera
R
R
Balaña-Fouce
R
R
Ordóñez
C
C
Ordóñez Escudero
D
D
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000378:metabolism; D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form; D004338:Drug Combinations; D006984:Hypertrophy / Q000097:blood / Q000139:chemically induced; D007527:Isoenzymes / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D010805:Physical Conditioning, Animal / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000318:Adrenergic beta-Agonists; D004338:Drug Combinations; D007527:Isoenzymes; D011433:Propranolol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; D000420:Albuterol