Chronic multiple paraneoplastic syndromes.
A patient presented with symptoms of limbic and brainstem encephalitis, motor and sensory neuronopathy, cerebellar dysfunction, and highly positive anti-Hu antibodies. He also harbored P/Q-type calcium channel antibodies and manifested the Lambert-Eaton myasthenic syndrome (LEMS). Small-cell lung cancer was found, and he received both antineoplastic therapy and intravenous immunoglobulin (IVIg). Remission of the malignancy was achieved. Although the anti-Hu-related manifestations improved after therapy, LEMS has persisted, leading to IVIg dependency.
Kleopa
K A
KA
Department of Neurology, 3 West Gates, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania 19104-4283, USA. kleopa@mail.med.upenn.edu
Teener
J W
JW
Scherer
S S
SS
Galetta
S L
SL
Bird
S J
SJ
D001323:Autoantibodies / Q000097:blood; D020864:Calcium Channels, N-Type / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000150:complications; D002908:Chronic Disease; D051959:ELAV Proteins; D004576:Electromyography; D006801:Humans; D016756:Immunoglobulins, Intravenous; D015624:Lambert-Eaton Myasthenic Syndrome / Q000150:complications* / Q000276:immunology / Q000628:therapy*; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology; D009431:Neural Conduction; D010257:Paraneoplastic Syndromes / Q000150:complications* / Q000276:immunology / Q000628:therapy*; D016601:RNA-Binding Proteins / Q000276:immunology
D001323:Autoantibodies; D020864:Calcium Channels, N-Type; D051959:ELAV Proteins; D016756:Immunoglobulins, Intravenous; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins