title: Two-step immunoablative treatment with autologous peripheral blood CD34(+) cell transplantation in an 8-year-old boy with autoimmune haemolytic anaemia.
abstract: Life-threatening haemolysis in children with autoimmune haemolytic anaemia (AIHA) occurs rarely. Many cases of severe autoimmune disease are currently treated with immunosuppressive high-dose chemotherapy and autograft. We report here a case of a child with severe AIHA who did not respond to conventional treatments, but was cured with an autologous peripheral blood CD34(+) cell transplantation. After d 16 post autograft, no further red cell transfusions were required. At 20 months post autograft, haematological complete remission persists.
authors.affiliation: Unité Bioclinique de Thérapie Cellulaire et de Transplantation Médullaire, Pédiatrie B, CHU Clermont-Ferrand, France. paillard@usa.net
authors.forename: C
authors.initials: C
authors.lastname: Paillard
authors.forename: J
authors.initials: J
authors.lastname: Kanold
authors.forename: P
authors.initials: P
authors.lastname: Halle
authors.forename: K
authors.initials: K
authors.lastname: Yakouben
authors.forename: N
authors.initials: N
authors.lastname: Boiret
authors.forename: C
authors.initials: C
authors.lastname: Rapatel
authors.forename: M
authors.initials: M
authors.lastname: Berger
authors.forename: G
authors.initials: G
authors.lastname: Malpuech
authors.forename: F
authors.initials: F
authors.lastname: Deméocq
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000628:therapy*; D018952:Antigens, CD34; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002330:Carmustine / Q000627:therapeutic use; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D003561:Cytarabine / Q000627:therapeutic use; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D010956:Plasmapheresis; D011034:Podophyllotoxin / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D013156:Splenectomy; D013234:Stem Cells / Q000276:immunology*; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D003561:Cytarabine; D003520:Cyclophosphamide; D011239:Prednisolone; D011034:Podophyllotoxin; D008558:Melphalan; D002330:Carmustine; D008775:Methylprednisolone