First manifestations of seronegative spondylarthropathy following autologous stem cell transplantation in HLA-B27-positive patients.
Two male patients with non-Hodgkin's lymphoma (NHL, follicular NHL, diffuse large B cell NHL, both in 2nd complete remission) and one female patient with acute myeloid leukemia in 1st complete remission developed arthralgias and enthesopathy following autologous stem cell transplantation. In 2/3 patients, sacroiliitis could be demonstrated on X-ray. In both patients, the rheumatic symptoms were classified as manifestations of a spondylarthropathy. All three patients were subsequently shown to be HLA-B27-positive. The patients were successfully treated with non-steroidal anti-inflammatory drugs. The differential diagnosis of joint pain following autologous stem cell transplantation should include HLA-B27-associated spondylarthropathies in addition to the more commonly seen bone and joint pain due to immobilization and medication.
Koch
B
B
Saarland University Rheumatology Center, Department of Internal Medicine I, Saarland University, Homburg, Germany.
Kranzhöfer
N
N
Pfreundschu
M
M
Pees
H W
HW
Trümper
L
L
D000328:Adult; D005260:Female; D015796:HLA-B27 Antigen / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000628:therapy; D008224:Lymphoma, Follicular / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000628:therapy; D008297:Male; D013167:Spondylitis, Ankylosing / Q000209:etiology* / Q000276:immunology
D015796:HLA-B27 Antigen