title: Cutaneous Rosai-Dorfman disease--a pathologic review of 2 cases.
abstract: Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare but distinct clinicopathologic entity characterised histologically by a benign s histiocytic proliferation. Isolated involvement of extranodal sites without concomitant nodal disease is rare. We describe the pathological features of 2 cases of Rosai-Dorfman disease that were clinically confined to the skin. In both male adult Chinese patients, proliferation of histiocytes was accompanied by S-100 protein expression demonstrated immunohistochemically within the histiocytes. The pathology of Rosai-Dorfman disease and its microscopic differential diagnoses are discussed.
authors.affiliation: Department of Pathology, Singapore General Hospital, Singapore.
authors.forename: K L
authors.initials: KL
authors.lastname: Chuah
authors.forename: P H
authors.initials: PH
authors.lastname: Tan
authors.forename: S G
authors.initials: SG
authors.lastname: Hwang
authors.forename: B H
authors.initials: BH
authors.lastname: Ong
authors.forename: K L
authors.initials: KL
authors.lastname: Chuan
mesh_terms: D000328:Adult; D015618:Histiocytosis, Sinus / Q000473:pathology*; D006801:Humans; D008297:Male; D012867:Skin / Q000473:pathology*