Varying intertrial interval reveals temporally defined memory deficits and enhancements in NTAN1-deficient mice.
The N-end rule is one ubiquitin-proteolytic pathway that relates the in vivo half-life of a protein to the identity of its N-terminal residue. NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1. An N-terminal arginine-bearing substrate protein is recognized, ubiquitylated by UBR1/E3alpha, and subsequently degraded by 26S proteasomes. Previous research showed that NTAN1-deficient mice exhibited impaired long-term memory in the Lashley III maze. Therefore, a series of studies, designed to assess the role of NTAN1 in short- and intermediate-term memory processes, was undertaken. Two hundred sixty mice (126 -/-; 134 +/ +) received Lashley III maze training with intertrial intervals ranging from 2-180 min. Results indicated that inactivation of NTAN1 amidase differentially affects short-, intermediate-, and long-term memory.
Balogh
S A
SA
Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs, Connecticut 06269, USA.
Kwon
Y T
YT
Denenberg
V H
VH
D000581:Amidohydrolases / Q000172:deficiency*; D000818:Animals; D005260:Female; D005838:Genotype; D008297:Male; D018782:Maze Learning; D008568:Memory; D008569:Memory Disorders / Q000209:etiology* / Q000235:genetics / Q000523:psychology*; D008570:Memory, Short-Term; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics / Q000523:psychology; D012016:Reference Values; D013997:Time Factors
D000581:Amidohydrolases