title: Reproducibility of renal length measurements with 99mTc-DMSA SPECT.
abstract: Renal length measurements are used in evaluating several abnormalities of the pediatric genitourinary tract. This study assesses reproducibility of renal length measurements obtained with 99mTc-dimercaptosuccinic acid (DMSA) SPECT.
  
  
  METHODS
  The lengths of 98 kidneys of 51 children (age range, 1-16 y; mean age, 5.4 y) who underwent 99mTc-DMSA SPECT were measured independently by 2 observers. Renal length was calculated by converting pixels between points at the superior and inferior renal margins on a summated coronal image to centimeters. Lengths were measured for kidneys as they appeared in situ and after realignment along their long axes. SPECT reconstruction, choice of display parameters, positioning of points used for measuring, and alignment were performed independently by each observer. Interobserver variability, interobserver correlation, and mean differences between observers' measurements (expressed as measurement of observer 2 - measurement of observer 1) were calculated.
  
  
  RESULTS
  Correlation between the observers' measurements was highly significant for both nonaligned and aligned studies (r = 0.95 and 0.97, respectively; both, P < 0.0001). Interobserver variability expressed as 1 SD was 3.6 mm for nonaligned studies and 2.8 mm for aligned studies. The mean difference between the 2 observers' measurements for nonaligned studies was 2.0 +/- 4.8 mm (P < 0.0001) with a range of -11 to 14 mm. For aligned studies the mean difference between the 2 observers' measurements was -0.1 +/- 4.0 mm (P = 0.88) with a range of -20 to 10 mm. Differences between observers were not dependent on absolute renal length (P = 0.68 for nonaligned studies; P = 0.40 for aligned studies).
  
  
  CONCLUSIONS
  The variability in renal length measurements determined by 99mTc-DMSA SPECT is similar to that reported previously using sonography. Because the interobserver differences in renal length are similar to annual renal growth rates during childhood, caution should be applied when incorporating renal length measurements determined by 99mTc-DMSA SPECT into management algorithms. Additional studies are required to further establish interobserver variability, to assess intraobserver variability, and to evaluate means of improving standardization.
authors.affiliation: Department of Radiology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: E
authors.initials: E
authors.lastname: Lin
authors.forename: L P
authors.initials: LP
authors.lastname: Connolly
authors.forename: D
authors.initials: D
authors.lastname: Zurakowski
authors.forename: J
authors.initials: J
authors.lastname: DiCanzio
authors.forename: L
authors.initials: L
authors.lastname: Drubach
authors.forename: K
authors.initials: K
authors.lastname: Mitchell
authors.forename: T
authors.initials: T
authors.lastname: Tetrault
authors.forename: S P
authors.initials: SP
authors.lastname: Laffin
authors.forename: S T
authors.initials: ST
authors.lastname: Treves
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007668:Kidney / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D008297:Male; D015588:Observer Variation; D010648:Phenylacetates / Q000097:blood*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: C415251:6-fluoro-3-hydroxyphenylacetic acid; D010648:Phenylacetates; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid