title: The kings schizotypy questionnaire as a quantitative measure of schizophrenia liability.
abstract: We used a new self-report measure, the Kings Schizotypy Questionnaire (KSQ; Williams, M. The psychometric assessment of schizotypal personality. PhD thesis. Institute of Psychiatry, University of London, 1993), to investigate schizotypy as a quantitative measure of familial liability to schizophrenia. The KSQ was administered to 135 DSM-IV schizophrenia probands, 153 of their healthy first-degree relatives, and 267 control subjects. We found that the questionnaire clearly differentiated schizophrenic from non-schizophrenic individuals, but failed to differentiate the relatives from controls. Possible reasons for this include defensive responding among relatives, self-selection bias among relatives, differences in data collection methods, and the possibility that positive aspects of schizotypy may not be closely related to familial liability to schizophrenia.
authors.affiliation: Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF14 4XN, Cardiff, UK. jonesla1@cardiff.ac.uk
authors.forename: L A
authors.initials: LA
authors.lastname: Jones
authors.forename: A G
authors.initials: AG
authors.lastname: Cardno
authors.forename: K C
authors.initials: KC
authors.lastname: Murphy
authors.forename: R D
authors.initials: RD
authors.lastname: Sanders
authors.forename: M Y
authors.initials: MY
authors.lastname: Gray
authors.forename: G
authors.initials: G
authors.lastname: McCarthy
authors.forename: P
authors.initials: P
authors.lastname: McGuffin
authors.forename: M J
authors.initials: MJ
authors.lastname: Owen
authors.forename: J
authors.initials: J
authors.lastname: Williams
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D012559:Schizophrenia / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D006113:United Kingdom / Q000453:epidemiology