Unusual adverse events following peripheral blood stem cell (PBSC) mobilisation using granulocyte colony stimulating factor (G-CSF) in healthy donors.
Here, we describe two cases of severe pyogenic infection in healthy donors diagnosed immediately following stem cell mobilisation with G-CSF. In the first donor a painful perianal abscess and in the second one an apical abscess required surgical incision. The reported serious adverse events in the literature are reviewed and the potential pathophysiological role of G-CSF or GM-CSF in augmenting inflammatory processes is discussed. In the light of a rapidly increasing number of related and unrelated peripheral blood stem cell donations the need for more comprehensive donor work-up and follow-up for peripheral blood stem cell donors has to be considered. Bone Marrow Transplantation (2000) 26, 811-813.
Hilbe
W
W
BMT Unit, Dept of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria.
Nussbaumer
W
W
Bonatti
H
H
Thaler
J
J
Niederwieser
D
D
Nachbaur
D
D
D000328:Adult; D001782:Blood Donors; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007239:Infections / Q000139:chemically induced; D007937:Leukapheresis; D008297:Male; D008875:Middle Aged
D016179:Granulocyte Colony-Stimulating Factor