DNA vaccines.
The premise that DNA coding for antigens produces proteins to stimulate the immune system when inoculated directly into muscle tissues, has the immense attractions of simplicity, versatility and economy. When other vaccination approaches are experiencing practical problems, meeting such challenges as AIDS and malaria, considerable attention has focused on DNA vaccines with entire conferences and a flood of commercial companies devoted to exploring the possibilities. A number of clinical trials for both infectious diseases and cancer have already commenced, even though a number of major issues have to be resolved.
Scott-Taylor
T H
TH
Department of Oncology, St George's Hospital Medical School, London, SW17 0RE, UK.
Dalgleish
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AG
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy; D019496:Cancer Vaccines / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D008288:Malaria / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy; D009369:Neoplasms / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy; D019444:Vaccines, DNA / Q000627:therapeutic use
D019496:Cancer Vaccines; D019444:Vaccines, DNA