Elevation of the gamma-aminobutyric acid transaminase expression in the gerbil CA1 area after ischemia-reperfusion damage.
gamma-Aminobutyric acid-transaminase (GABA-T) plays an important role in the metabolism of GABA, particularly in the neurons or glial cells. The present study was undertaken to determine the alteration of GABA-T expression in the gerbil hippocampus after ischemia-reperfusion. In the sham, GABA-T(+) neurons were scattered in the hippocampus proper and dentate gyrus. The intensity of the GABA-T immunoreactivity had nearly disappeared in the interneurons at 12 h after ischemia. In contrast, 24 h post-ischemia the dramatic augmentation of GABA-T immunoreactivity in the pyramidal cells was observed in the CA1 area but not in the CA2 or CA3 areas. Forty-eight hours after ischemia-reperfusion, its immunoreactivity was preserved in the CA1 neurons. These results suggest that the over-expression of GABA-T in the CA1 area may be related to delayed neuronal death after ischemia-reperfusion insult.
Kang
T C
TC
Department of Anatomy, College of Medicine, Hallym University, Chunchon, 200-702, Kangwon-Do, South Korea.
Park
S K
SK
Bahn
J H
JH
Chang
J S
JS
Koh
W S
WS
Jo
S M
SM
Cho
S W
SW
Choi
S Y
SY
Won
M H
MH
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D004195:Disease Models, Animal; D004591:Electrophoresis, Polyacrylamide Gel; D005849:Gerbillinae; D006624:Hippocampus / Q000201:enzymology* / Q000473:pathology; D007150:Immunohistochemistry; D007395:Interneurons / Q000201:enzymology / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000150:complications / Q000201:enzymology*; D008297:Male; D017966:Pyramidal Cells / Q000201:enzymology / Q000473:pathology; D015427:Reperfusion Injury / Q000201:enzymology* / Q000209:etiology
D000612:4-Aminobutyrate Transaminase