Study on the decomposition products of thiadiazinthione and their anticancer properties.
Study of the anticancer properties of thirty-four 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives has been carried out by using cytotoxicity assays against HeLa, HT-29 and Hep G2 cells. The decomposition products of thiadiazinthione 1 m have been studied and their anticancer properties evaluated.
Pérez
R
R
Laboratorio de Síntesis Orgánica, Facultad de Qímica, Universidad de La Habana, Cuba.
Rodríguez
H
H
Pérez
E
E
Suárez
M
M
Reyes
O
O
González
L J
LJ
López de Cerain
A
A
Ezpelata
O
O
Pérez
C
C
Ochoa
C
C
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D013829:Thiadiazines / Q000737:chemistry* / Q000494:pharmacology*; D013871:Thiones / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D013829:Thiadiazines; D013871:Thiones