Synthesis and antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 2-acetylpyridine and benzimidazole derivatives.
Reaction of [Ru(eta4-C8H12) (CH3CN)2 Cl2] with 2-(2-pyridyl) benzimidazole or Schiff bases derived from 2-acetylpyridine and S-methyldithiocarbazate, S-benzyldithiocarbazate and thiosemicarbazide leads to form new complexes of the type [Ru(eta4-C8H12)(L)Cl2] (where L=ligand). In vitro, most of the compounds exhibited potent activity and the Ru derivatives 1a [Ru(eta4-C8H12)(2-Acpy-SMDT)Cl2], 2a [Ru(eta4-C8H12)(2-Acpy-SBDT)Cl2] and 3a [Ru(eta4-CsH12)(2-Acpy-TSC)Cl2] were found more active than metronidazole against (HK-9) strain of Entamoeba histolytica.
Bharti
N
N
Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.
Maurya
M R
MR
Naqvi
F
F
Azam
A
A
D000563:Amebicides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D004748:Entamoeba histolytica / Q000187:drug effects; D007202:Indicators and Reagents; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D011725:Pyridines; D012238:Rhodium; D012545:Schiff Bases; D013329:Structure-Activity Relationship
D000563:Amebicides; D001562:Benzimidazoles; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D011725:Pyridines; D012545:Schiff Bases; D012238:Rhodium