title: IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.
abstract: We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in multiple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8.
authors.affiliation: Department of Molecular Biology, Genentech Inc., San Francisco, California 94080, USA.
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: W H
authors.initials: WH
authors.lastname: Ho
authors.forename: M
authors.initials: M
authors.lastname: Maruoka
authors.forename: R T
authors.initials: RT
authors.lastname: Corpuz
authors.forename: D T
authors.initials: DT
authors.lastname: Baldwin
authors.forename: J S
authors.initials: JS
authors.lastname: Foster
authors.forename: A D
authors.initials: AD
authors.lastname: Goddard
authors.forename: D G
authors.initials: DG
authors.lastname: Yansura
authors.forename: R L
authors.initials: RL
authors.lastname: Vandlen
authors.forename: W I
authors.initials: WI
authors.lastname: Wood
authors.forename: A L
authors.initials: AL
authors.lastname: Gurney
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D017124:Conserved Sequence; D005260:Female; D015723:Gene Library; D006801:Humans; D020381:Interleukin-17 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D016209:Interleukin-8 / Q000096:biosynthesis; D007668:Kidney / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology / Q000821:virology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D009928:Organ Specificity; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D018123:Receptors, Interleukin / Q000235:genetics / Q000378:metabolism*; D053722:Receptors, Interleukin-17; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D014162:Transfection; D016662:Virus Integration
chemical_list: C109985:IL17RA protein, human; C491673:Il17ra protein, mouse; D020381:Interleukin-17; D016209:Interleukin-8; D016328:NF-kappa B; D020033:Protein Isoforms; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17; D011994:Recombinant Proteins