title: Camptothecin and mitomycin combination chemotherapy on ovarian clear cell carcinoma with multiple systemic metastases.
abstract: Ovarian clear cell carcinoma is known for decreased responsiveness to most anticancer drugs, and the prognosis of patients with ovarian clear cell tumors is very poor. We report such a patient with multiple systemic metastases who showed a complete response to combined camptothecin and mitomycin chemotherapy. During therapy, clinical drug-resistance was observed transiently, but response was restored by intermittent administrations of camptothecin. Such combination chemotherapy may be a useful alternative regimen for advanced and/or metastatic ovarian clear cell carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: N
authors.initials: N
authors.lastname: Umesaki
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary
chemical_list: D016685:Mitomycin; D002166:Camptothecin