title: Cytogenetic and fluorescence in situ hybridization studies in four cases of plasma cell leukemia.
abstract: We present a cytogenetic and fluorescence in situ hybridization (FISH) study, using centromeric probes for chromosomes 3, 7, 11, and 18, TP53 gene (17p13), and RB-1 locus (13q14) DNA probes, in four cases of plasma cell leukemia (PCL). Among the four cases, three presented monosomy of the RB-1 locus and one monoallelic deletion of the TP53 gene. The present report shows the usefulness of the FISH technique to detect abnormalities not previously observed by conventional cytogenetics.
authors.affiliation: Laboratori de Citologia Hematològica/Laboratori de Referència de Catalunya, Unitat d'Hematologia, Hospital del Mar, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Lloveras
authors.forename: F
authors.initials: F
authors.lastname: Solé
authors.forename: B
authors.initials: B
authors.lastname: Espinet
authors.forename: C
authors.initials: C
authors.lastname: Besses
authors.forename: A
authors.initials: A
authors.lastname: Asensio
authors.forename: E
authors.initials: E
authors.lastname: Abella
authors.forename: S
authors.initials: S
authors.lastname: Woessner
authors.forename: L
authors.initials: L
authors.lastname: Florensa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015342:DNA Probes; D004276:DNA, Satellite; D005260:Female; D016161:Genes, Retinoblastoma; D016158:Genes, p53; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007952:Leukemia, Plasma Cell / Q000235:genetics*; D008297:Male
chemical_list: D015342:DNA Probes; D004276:DNA, Satellite