title: Activation of ATP receptor increases the cytosolic Ca(2+) concentration in nucleus accumbens neurons of rat brain.
abstract: ATP increased the cytosolic Ca(2+) concentration ([Ca](i)) in nucleus accumbens neurons acutely dissociated from rat brain. The ATP response was dependent on external Ca(2+) and Na(+), and was blocked by voltage-dependent Ca(2+) channel blockers. The results suggest that the ATP-induced depolarization increases Ca(2+) influx resulting in the increase in [Ca](i).
authors.affiliation: Department of Physiology, Kagoshima University, Faculty of Medicine, 890-8520, Kagoshima, Japan. ciliary@med2.kufm.kagoshima-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Sorimachi
authors.forename: T
authors.initials: T
authors.lastname: Moritoyo
authors.forename: K
authors.initials: K
authors.lastname: Yamagami
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D058919:Purinergic P2 Receptor Antagonists; D051381:Rats; D017208:Rats, Wistar; D018048:Receptors, Purinergic P2 / Q000378:metabolism
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D000255:Adenosine Triphosphate; D002118:Calcium