Frontiers in chemical genetics.
New methods enable the identification of compounds that both induce a specific cellular state and lead to identification of proteins that regulate that state. Together, developments in three critical areas: chemical diversity, phenotype-based screening and target identification, enable the systematic application of this chemical genetic approach to almost any biological problem or disease process.
Stockwell
B R
BR
Whitehead Institute for Biomedical Research, Nine Cambridge Center, MA 02142, USA. stockwell@wi.mit.edu
D000818:Animals; D001704:Biopolymers; D001709:Biotechnology; D002625:Chemistry, Organic; D005819:Genetic Markers; D005820:Genetic Testing; D006801:Humans; D008957:Models, Genetic; D008967:Molecular Biology / Q000639:trends*; D055601:Organic Chemistry Phenomena; D010641:Phenotype
D001704:Biopolymers; D005819:Genetic Markers