title: Single sweep analysis of event related auditory potentials for the monitoring of sedation in cardiac surgery patients.
abstract: Event-related potentials (ERPs) from the auditory system were investigated in 28 post-operative cardiac patients in order to assess their relevance in the monitoring of patient sedation level. Midazolam (17 patients) and propofol (11 patients) were the sedative agents used. The auditory ERP components of N100 (HAB100) and mismatch negativity (MMN) were considered. A single sweep method based on the AutoRegressive with eXogenous input (ARX) model, which is able to enhance the evoked responses to each single stimulus, was used to process each sweep and to compute traditional parameters on a sweep-by-sweep basis. Differences in the measured parameters were related to variations in the patient sedation levels classified through Ramsay score. Significant differences (P<0.05) in both MMN and HAB100 parameters were found between light sedation (LS) and deep sedation (DS) levels.
authors.affiliation: Department of Biomedical Engineering, Polytechnic University, Via Golgi 39, 20133 Milan, Italy. mainardi@cdc8g5.cdc.polimi.it
authors.forename: L T
authors.initials: LT
authors.lastname: Mainardi
authors.forename: J
authors.initials: J
authors.lastname: Kupila
authors.forename: K
authors.initials: K
authors.lastname: Nieminen
authors.forename: I
authors.initials: I
authors.lastname: Korhonen
authors.forename: A M
authors.initials: AM
authors.lastname: Bianchi
authors.forename: L
authors.initials: L
authors.lastname: Pattini
authors.forename: J
authors.initials: J
authors.lastname: Takala
authors.forename: J
authors.initials: J
authors.lastname: Karhu
authors.forename: S
authors.initials: S
authors.lastname: Cerutti
mesh_terms: D000368:Aged; D000465:Algorithms; D006348:Cardiac Surgical Procedures; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D008874:Midazolam / Q000627:therapeutic use; D008875:Middle Aged; D008991:Monitoring, Physiologic; D015742:Propofol / Q000627:therapeutic use; D012815:Signal Processing, Computer-Assisted
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam; D015742:Propofol