title: Models for chromatid interference with applications to recombination data.
abstract: Genetic interference means that the occurrence of one crossover affects the occurrence and/or location of other crossovers in its neighborhood. Of the three components of genetic interference, two are well modeled: the distribution of the number and the locations of chiasmata. For the third component, chromatid interference, there exists only one model. Its application to real data has not yet been published. A further, new model for chromatid interference is presented here. In contrast to the existing model, it is assumed that chromatid interference acts only in the neighborhood of a chiasma. The appropriateness of this model is demonstrated by its application to three sets of recombination data. Both models for chromatid interference increased fit significantly compared to assuming no chromatid interference, at least for parts of the chromosomes. Interference does not necessarily act homogeneously. After extending both models to allow for heterogeneity of chromatid interference, a further improvement in fit was achieved.
authors.affiliation: Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany. teuscher@fbn-dummerstorf.de
authors.forename: F
authors.initials: F
authors.lastname: Teuscher
authors.forename: G A
authors.initials: GA
authors.lastname: Brockmann
authors.forename: P E
authors.initials: PE
authors.lastname: Rudolph
authors.forename: H H
authors.initials: HH
authors.lastname: Swalve
authors.forename: V
authors.initials: V
authors.lastname: Guiard
mesh_terms: D000818:Animals; D002417:Cattle; D002842:Chromatids / Q000235:genetics*; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D016013:Likelihood Functions; D008957:Models, Genetic; D015233:Models, Statistical; D011995:Recombination, Genetic