Pre-natal sensitization in humans.
Allergy has a very strong hereditary component but even in identical twins, concordance for the development of allergic disease can be as low as 50%. This suggests that there is a very strong environmental influence on manifestations of sensitization. To what extent environment might have an influence on the ontogeny of sensitization antenatally has hitherto not been a focus of much research. However, circumstantial evidence suggests that this may be important.
Warner
J O
JO
Child Health, University of Southampton/Southampton General Hospital, UK. jow@soton.ac.uk
Jones
C A
CA
Kilburn
S A
SA
Vance
G H
GH
Warner
J A
JA
D000485:Allergens / Q000276:immunology*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology*; D007109:Immunity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D000485:Allergens