title: Penicillamine induced lupus-like syndrome: a case report.
abstract: Several drugs have been suggested to cause lupus-like syndrome. However, penicillamine-induced lupus-like syndrome has only rarely been reported in patients with Wilson's disease. We describe a 6- year-old Taiwanese girl, with a diagnosis of Wilson's disease in November, 1997, who developed lupus-like syndrome 17 months after penicillamine treatment. After treatment with prednisolone and decrease in the dose of penicillamine, her symptoms subsided gradually. This is the first such case reported in a Taiwanese patient. Because the symptoms of drug-induced lupus (DIL) are nonspecific, subjective and variable, the diagnosis of DIL requires awareness of DIL-inducing potential of chronic medication.
authors.affiliation: Department of Pediatrics, Provincial Keelung Hospital, Taiwan, ROC.
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: K C
authors.initials: KC
authors.lastname: Hwang
authors.forename: H J
authors.initials: HJ
authors.lastname: Lee
authors.forename: M J
authors.initials: MJ
authors.lastname: Tsai
authors.forename: Y H
authors.initials: YH
authors.lastname: Ni
authors.forename: B L
authors.initials: BL
authors.lastname: Chiang
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000175:diagnosis; D010396:Penicillamine / Q000009:adverse effects*
chemical_list: D010396:Penicillamine