Complexes of gallium(III) and other metal ions and their potential in the treatment of neoplasia.
The metal complexes of a variety of ligands show diverse pharmacological properties. The potential of these compounds as antineoplastic agents is underlined by the success of the clinically used platinum complex cisplatin (cis-[(NH(3))(2)PtCl(2)]). In the current review, specific examples of gallium, copper, ruthenium and titanium complexes are discussed with special relevance to their use in the treatment of cancer. Some of these complexes have demonstrated marked activity in a number of animal models and for some compounds, clinical trials are anticipated or have already begun. Collectively, the results in the literature indicate that the study of metal complexes as antineoplastic agents deserves continued intensive investigation.
Richardson
D R
DR
The Heart Research Institute, 145 Missenden Rd, Camperdown, Sydney, New South Wales, Australia, 2050. D.Richardson@hri.org.au.
Lovejoy
D B
DB
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005708:Gallium / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D005708:Gallium