Combined therapy with hypothermia and anticytokine agents in influenza A encephalopathy.
Two children with influenza A-related encephalopathy were treated with a combination of mild hypothermia (deep body temperature of the forehead: 35 degrees C) and anticytokine agents (high-dose methylprednisolone and ulinastatin), while receiving amantadine. One of the cases exhibited acute necrotizing encephalopathy on computed tomography (CT). Although no severe complications occurred, correctable hypokalemia and hyperglycemia occurred in both cases. Both patients recovered without any neurological sequelae. Our therapeutic protocol appears to be effective for managing influenza A-related encephalopathy.
Munakata
M
M
Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan. muna@ped.med.tohoku.ac.jp
Kato
R
R
Yokoyama
H
H
Haginoya
K
K
Tanaka
Y
Y
Kayaba
J
J
Kato
T
T
Takayanagi
R
R
Endo
H
H
Hasegawa
R
R
Ejima
Y
Y
Hoshi
K
K
Iinuma
K
K
D000547:Amantadine / Q000008:administration & dosage / Q000009:adverse effects; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000821:virology; D002675:Child, Preschool; D016207:Cytokines / Q000037:antagonists & inhibitors*; D018450:Disease Progression; D018792:Encephalitis, Viral / Q000188:drug therapy* / Q000473:pathology / Q000821:virology*; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D009980:Influenza A virus / Q000187:drug effects* / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects; D009976:Orthomyxoviridae Infections / Q000150:complications* / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014361:Trypsin Inhibitors / Q000008:administration & dosage / Q000009:adverse effects
D016207:Cytokines; D006023:Glycoproteins; D014361:Trypsin Inhibitors; D000547:Amantadine; C028665:urinastatin; D008775:Methylprednisolone