An intra-articular method for assessing topical application to a synovial joint.
Intra-articular injection of drugs is increasingly used in human medicines. We report a method for the direct administration of a test substance to the synovial fluid of the canine stifle joint. This method caused little distress or pathology, making it suitable for pre-clinical assessment of new drugs in dogs and other species.
Holland
T
T
Covance Laboratories Limited, Harrogate, UK.
Jones
R
R
Basford
A
A
Child
T
T
Smith
A
A
D000818:Animals; D018501:Antirheumatic Agents / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D007270:Injections, Intra-Articular / Q000379:methods*; D007719:Knee Joint / Q000187:drug effects* / Q000473:pathology; D012965:Sodium Chloride / Q000008:administration & dosage; D013583:Synovial Membrane / Q000187:drug effects / Q000473:pathology; D013585:Synovitis / Q000139:chemically induced / Q000473:pathology
D018501:Antirheumatic Agents; D012965:Sodium Chloride