Acute renal failure due to idiopathic tubulo-intestinal nephritis and uveitis: "TINU syndrome". Case report and review of the literature.
Acute renal failure due to idiopathic tubulo-interstitial nephritis associated with bilateral uveitis (TINU syndrome) is a rare clinical event, contracted mainly by girls or women. Here we report the clinical follow-up regarding a 22-year-old woman with acute renal failure (creat. clearance 13.5 ml/min) due to idiopathic tubulo-interstitial nephritis documented by renal biopsy, after bilateral uveitis which healed with local prednisone. The clinical history and the clinical follow-up of our patient were typical of the TINU syndrome. We were able to exclude all diseases causing acute tubulo-interstitial nephritis such as systemic infection, hypersensitivity to drugs, Behcet's disease, Sjogren syndrome, sarcoidosis, systemic lupus or vasculitides. The patient recovered after systemic prednisone.
Sessa
A
A
Nephrology and Dialysis Unit, General Hospital, Vimercate, Italy. adsess@tin.it
Meroni
M
M
Battini
G
G
Viganò
G
G
Brambilla
P L
PL
Paties
C T
CT
D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*; D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D009395:Nephritis, Interstitial / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D013577:Syndrome; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis