Iodinated natural rubber latex: preparation, characterisation & antibacterial activity assessment.
Natural Rubber (NR) in both its latex and dried form was treated with iodine to make it antibacterial in nature. The NR latex was dried and washed, dissolved in toluene, iodinated and cast into films. In a different approach, NR in its latex form (emulsion) was blended with aqueous solution of povidone-iodine complex (PVP-I) and films were cast. Phase separation of PVP-I was observed in the films prepared using NR latex; whereas the film prepared using NR solution in toluene and molecular iodine were homogeneous, transparent light brown. Solubility assessment of the films revealed that unlike pure NR, the iodinated NR failed to go into solution completely. The films obtained from both the approaches were evaluated for release of iodide ions. On immersion in water, PVP-I blended latex did not retain iodine while sustained release of iodide ion was observed in case of dried NR dissolved in toluene and treated with iodine. The FT-IR spectra of the iodinated films revealed that iodine attaches covalently to the double bonds in the isoprene units of NR. The films were also evaluated for their antibacterial properties and it was observed that the films prepared from both the approaches, acquired antimicrobial properties.
Tyagi
M
M
Centre for Biomedical Engineering, Indian Institute of Technology, New Delhi.
Singh
S
S
Singh
H
H
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D003890:Desiccation; D004926:Escherichia coli / Q000187:drug effects; D007454:Iodides / Q000032:analysis; D007455:Iodine / Q000737:chemistry*; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D011206:Povidone-Iodine / Q000737:chemistry; D012408:Rubber / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D012997:Solvents; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D014050:Toluene; D014867:Water
D000900:Anti-Bacterial Agents; D007454:Iodides; D012997:Solvents; D014867:Water; D014050:Toluene; D011206:Povidone-Iodine; D012408:Rubber; D007455:Iodine