title: Effect of postmenopausal hormone replacement therapy on dental outcomes: systematic review of the literature and pharmacoeconomic analysis.
abstract: A systematic review and economic analysis of clinical trials evaluating the effect of hormone replacement therapy (HRT) on dental outcomes in postmenopausal women were conducted. Twenty published studies involving more than 13,735 postmenopausal women were summarized and analyzed. In prospective studies, the effect of HRT on osteoporosis (OP) has been well documented. The effect of OP on mandibular bone density has also been examined in some observational studies. Few studies, however, have examined the effect of HRT directly on mandibular bone density or on dental outcomes. From these studies, the effect of HRT on costs of dental treatment and prophylaxis was estimated directly and indirectly. It was determined that HRT use was associated with reduction in adverse dental outcomes and the associated costs of dental care. Annualized excess cost in a cohort of 1,000 untreated women averaged $100,000. From this analysis, it is clear that postmenopausal women with OP who do not receive HRT have a greater incidence of adverse dental outcomes and higher dental care costs than those who do.
authors.affiliation: Babson College, Babson Park, Massachusetts, USA.
authors.forename: I E
authors.initials: IE
authors.lastname: Allen
authors.forename: M
authors.initials: M
authors.lastname: Monroe
authors.forename: J
authors.initials: J
authors.lastname: Connelly
authors.forename: R
authors.initials: R
authors.lastname: Cintron
authors.forename: S D
authors.initials: SD
authors.lastname: Ross
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D003365:Costs and Cost Analysis; D003729:Dental Care / Q000191:economics*; D005260:Female; D020249:Hormone Replacement Therapy / Q000191:economics*; D006801:Humans; D008334:Mandible / Q000473:pathology; D008875:Middle Aged; D010024:Osteoporosis / Q000191:economics / Q000517:prevention & control; D017698:Postmenopause; D016388:Tooth Loss / Q000191:economics / Q000517:prevention & control; D016896:Treatment Outcome; D014481:United States