[Non-transmitter effect of acetylcholine in the neuromuscular preparation].
Acetylcholine was shown to maintain the efficiency of a fatigued muscle of rat increasing the evoked transmitter release and inducing a hyperpolarization of the muscle fibre membrane. The effects proved to be long-term ones. Modulatory effects of acetylcholine were shown to be realized via structures which differed pharmacologically from the typical n- and m-cholinoreceptors with the participation of ouabain-sensitive isoforms of Na+, K(+)-ATPase. The data obtained corroborates existence of a long-term neuronal regulation of the neuromuscular transmission efficiency involving non-quantal acetylcholine. The regulatory pathways are supposed to be different in muscle fibres with different functional characteristics and different ability of adaptation under physiological loading.
Krivoĭ
I I
II
St. Petersburg State University, Russia.
D000109:Acetylcholine / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D003964:Diaphragm / Q000294:innervation / Q000502:physiology; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008564:Membrane Potentials; D009119:Muscle Contraction; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology; D051381:Rats; D009435:Synaptic Transmission
D000109:Acetylcholine