Metabolic aspects of glycosomes in trypanosomatidae - new data and views.
The energy metabolism of Trypanosomatidae has been the subject of many reviews during the past decade. In recent years, however, new data have led to a more complete picture of trypanosomatid metabolism and a reappraisal of the role of some characteristic organelles in the energy supply of these parasites. For years, the glycosome was thought to be a peroxisome-like organelle that had evolved to allow the parasites to carry out glycolysis at a high rate using a relatively small amount of enzyme. However, the results of recent studies of trypanosomatid glycolysis and the detection of various other pathways and enzymes in the organelle necessitate a modification of this view. Here, Paul Michels, Véronique Hannaert and Frédéric Bringaud review the new data and discuss the possible implications for our view on the role of the glycosome.
Michels
P A
PA
Research Unit for Tropical Diseases, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium. michels@trop.ucl.ac.be
Hannaert
V
V
Bringaud
F
F
D000818:Animals; D050260:Carbohydrate Metabolism; D004734:Energy Metabolism; D006019:Glycolysis; D008830:Microbodies / Q000378:metabolism*; D008954:Models, Biological; D014351:Trypanosomatina / Q000378:metabolism*