Infant zygosity can be assigned by parental report questionnaire data.
A parental report questionnaire posted to a population sample of 18-month-old twins correctly assigned zygosity in 95%of cases when validated against zygosity determined by identity of polymorphic DNA markers. The questionnaire was as accurate when readministered at 3 years of age, with 96% of children being assigned the same zygosity on both occasions. The results validate the use of parental report questionnaire data to determine zygosity in infancy.
Price
T S
TS
Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK. t.price@iop.kcl.ac.uk
Freeman
B
B
Craig
I
I
Petrill
S A
SA
Ebersole
L
L
Plomin
R
R
D016009:Chi-Square Distribution; D002675:Child, Preschool; D004247:DNA / Q000235:genetics; D004739:England; D005260:Female; D005500:Follow-Up Studies; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D010290:Parents; D011110:Polymorphism, Genetic / Q000235:genetics; D011795:Surveys and Questionnaires; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics; D014852:Wales
D005819:Genetic Markers; D004247:DNA