title: Intracerebral haemorrhages and oral anticoagulation in the north of Scotland.
abstract: The aim of this study has been twofold: 1--to examine the impact of oral anticoagulant (OAC) use on a possible recent rise in the admission rate of intracerebral haemorrhages to Aberdeen Royal Infirmary (ARI), and 2--to estimate the absolute risk of intracranial haemorrhage for outpatients followed up in the OAC Clinic at ARI. The number of patients admitted to ARI with intracerebral bleedings increased by 60% between 1993 and 1998. A corresponding increase in the proportion of patients with concurrent OAC use (4.7% vs 15.7%, p = 0.055) cannot sufficiently explain the increase in the total number of intracerebral haemorrhages. The average annual incidence of intracranial haemorrhages for the OAC Clinic at ARI is found to be acceptably low at 0.33% per year. Further audit of the large number of patients receiving warfarin outwith the supervision of the clinic is urgently required.
authors.affiliation: Clinical Pharmacology Unit, Aberdeen Royal Infirmary, Foresterhill.
authors.forename: J
authors.initials: J
authors.lastname: Berwaerts
authors.forename: O J
authors.initials: OJ
authors.lastname: Robb
authors.forename: T A
authors.initials: TA
authors.lastname: Jeffers
authors.forename: J
authors.initials: J
authors.lastname: Webster
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000009:adverse effects*; D016009:Chi-Square Distribution; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D020300:Intracranial Hemorrhages / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality; D012307:Risk Factors; D012606:Scotland / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D014859:Warfarin