title: Serum levels of coenzyme Q10 in patients with amyotrophic lateral sclerosis.
abstract: To elucidate whether serum coenzyme Q10 levels are related with the risk for amyotrophic lateral sclerosis (ALS), we compared serum levels of coenzyme Q10 and the coenzyme Q10/cholesterol ratio, in 30 patients with ALS and 42 matched controls using a high performance liquid chromatography technique. The mean serum coenzyme Q10 levels and the coenzyme Q10/cholesterol ratio did not differ significantly between the 2 study groups. These values were not influenced by the clinical form (spinal vs. bulbar) of ALS, and they did not correlate with age, age at onset, and duration of the disease. These results suggest that serum coenzyme Q10 concentrations are unrelated with the risk for ALS.
authors.affiliation: Department of Neurology, Hospital Universitario Doce de Octubre, Alcala de Henares, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Molina
authors.forename: F
authors.initials: F
authors.lastname: de Bustos
authors.forename: F J
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.forename: C
authors.initials: C
authors.lastname: Gómez-Escalonilla
authors.forename: A
authors.initials: A
authors.lastname: García-Redondo
authors.forename: J
authors.initials: J
authors.lastname: Esteban
authors.forename: A
authors.initials: A
authors.lastname: Guerrero-Sola
authors.forename: P
authors.initials: P
authors.lastname: del Hoyo
authors.forename: A
authors.initials: A
authors.lastname: Martínez-Salio
authors.forename: C
authors.initials: C
authors.lastname: Ramírez-Ramos
authors.forename: G R
authors.initials: GR
authors.lastname: Indurain
authors.forename: J
authors.initials: J
authors.lastname: Arenas
mesh_terms: D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000453:epidemiology; D000975:Antioxidants / Q000378:metabolism; D003067:Coenzymes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000097:blood*
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10