title: Spiny keratoderma of the palms and soles - report of two cases.
abstract: We report two patients with spiny keratoderma of the palms and soles characterized by multiple tiny keratotic plugs on the palms and soles. This disease was reported to be possibly associated with internal malignancies. We found a tumor from the esophagus to cardia in one patient. Another had no tumor but the lesion occurred soon after a severe bronchial asthma attack. Causal relation between spiny keratoderma of the palms and soles and bronchial asthma is obscure. Since this disease has been under-diagnosed and under-reported, it is important for dermatologists to keep spiny keratoderma of the palms and soles in mind in daily clinical examinations.
authors.affiliation: Department of Dermatology, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Handa
authors.forename: A
authors.initials: A
authors.lastname: Sakakibara
authors.forename: M
authors.initials: M
authors.lastname: Araki
authors.forename: N
authors.initials: N
authors.lastname: Yamanaka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D004938:Esophageal Neoplasms / Q000175:diagnosis; D005260:Female; D005533:Foot Dermatoses / Q000175:diagnosis* / Q000473:pathology; D006229:Hand Dermatoses / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007642:Keratosis / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000175:diagnosis; D011379:Prognosis; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed