Y chromosome sequence variation and the history of human populations.
Binary polymorphisms associated with the non-recombining region of the human Y chromosome (NRY) preserve the paternal genetic legacy of our species that has persisted to the present, permitting inference of human evolution, population affinity and demographic history. We used denaturing high-performance liquid chromatography (DHPLC; ref. 2) to identify 160 of the 166 bi-allelic and 1 tri-allelic site that formed a parsimonious genealogy of 116 haplotypes, several of which display distinct population affinities based on the analysis of 1062 globally representative individuals. A minority of contemporary East Africans and Khoisan represent the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa between 35,000 and 89,000 years ago.
Underhill
P A
PA
Department of Genetics, Stanford University, Stanford, California, USA.under@stanford.edu
Shen
P
P
Lin
A A
AA
Jin
L
L
Passarino
G
G
Yang
W H
WH
Kauffman
E
E
Bonné-Tamir
B
B
Bertranpetit
J
J
Francalacci
P
P
Ibrahim
M
M
Jenkins
T
T
Kidd
J R
JR
Mehdi
S Q
SQ
Seielstad
M T
MT
Wells
R S
RS
Piazza
A
A
Davis
R W
RW
Feldman
M W
MW
Cavalli-Sforza
L L
LL
Oefner
P J
PJ
D000349:Africa; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005006:Ethnicity / Q000235:genetics*; D019143:Evolution, Molecular; D006239:Haplotypes / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008297:Male; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009691:Nucleic Acid Denaturation; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D013045:Species Specificity; D014998:Y Chromosome / Q000235:genetics*