Reversible leukoencephalopathy associated with re-infusion of DMSO preserved stem cells.
We report a case of posterior reversible leuko- encephalopathy (PRL) following the infusion of dimethylsulfoxide (DMSO) cryopreserved autologous stem cells in the setting of myeloablative chemotherapy in a patient with recurrent Ewing's sarcoma. Magnetic resonance (MR) imaging revealed white matter changes which resolved over the next 2 months. Bone Marrow Transplantation (2000) 26, 797-800.
Higman
M A
MA
Departments of Oncology and Pediatrics, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Port
J D
JD
Beauchamp
N J
NJ
Chen
A R
AR
D000293:Adolescent; D015925:Cryopreservation / Q000379:methods; D004121:Dimethyl Sulfoxide / Q000633:toxicity*; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D011859:Radiography; D012512:Sarcoma, Ewing / Q000628:therapy; D013234:Stem Cells; D014182:Transplantation, Autologous
D004121:Dimethyl Sulfoxide