title: Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease.
abstract: The blood coagulation system has been shown to be activated in subacute exacerbations of Binswanger disease (BD). In our previous study, the antithrombin drug argatroban t ameliorated the neurological exacerbations in a BD patient with antiphospholipid antibody syndrome. We have further examined the therapeutic efficacy of argatroban in 3 BD patients with subacute exacerbations, but without any immune-mediated prothrombotic complications. In 1 out of these 4 patients, treatment with sodium ozagrel, an antiplatelet drug was applied, but was ineffective. In all patients, argatroban treatment reduced the levels of the hemostatic markers, with a corresponding improvement in cognitive dysfunction and gait disorders. These results suggest that the antithrombin effect is true also for BD patients not compromised by the immune-mediated prothrombotic condition.
authors.affiliation: Department of Neurology, Faculty of Medicine, Kyoto University.
authors.forename: H
authors.initials: H
authors.lastname: Tomimoto
authors.forename: I
authors.initials: I
authors.lastname: Akiguchi
authors.forename: R
authors.initials: R
authors.lastname: Ohtani
authors.forename: H
authors.initials: H
authors.lastname: Yagi
authors.forename: S
authors.initials: S
authors.lastname: Ogura
authors.forename: H
authors.initials: H
authors.lastname: Wakita
mesh_terms: D000208:Acute Disease; D000368:Aged; D000991:Antithrombins / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D015140:Dementia, Vascular / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010875:Pipecolic Acids / Q000627:therapeutic use*; D013449:Sulfonamides
chemical_list: D000991:Antithrombins; D010875:Pipecolic Acids; D013449:Sulfonamides; D001120:Arginine; C031942:argatroban