[Early T cell development in gene-targeted mutant mice].
Early intrathymic T cell development is highly coordinated and controlled by the interaction of a variety of molecules. The development of gene targeting technology provided a valuable tool to study the function of these molecules in vivo. The analysis of TCR and CD3 gene targeted mice indicated that CD44-CD25+ is a control point in early T cell development. At this stage, the expression of pre-TCR complex (composed of pre-TCR alpha, TCR beta and CD3) and/or its combination with unknown ligand provide signals for further progression beyond the CD44-CD25+ stage. The deficiency of any component in pre-TCR complex would lead to the blockage of T cell development at early stages.
Yu
Q
Q
Department of Immunology, Beijing Medical University.
Chen
W F
WF
D000818:Animals; D018390:Gene Targeting / Q000379:methods*; D016654:Genes, RAG-1 / Q000235:genetics; D019672:Genes, T-Cell Receptor / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D009154:Mutation; D013601:T-Lymphocytes / Q000166:cytology*