Chromosome cohesion: a polymerase for chromosome bridges.
How do cells ensure that sister chromatids produced during DNA replication stay connected with each other until their separation in anaphase? New insight is provided by the discovery of DNA polymerase kappa, which has been found to be required for building the connections between sister chromatids.
Uhlmann
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F
Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. fuhlmann@icrf.icnet.uk
D002842:Chromatids; D002875:Chromosomes; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism
D004259:DNA-Directed DNA Polymerase