[Concentration of selected cytokines associated with monocytes/macrophages in serum of patients with different clinical stages of pulmonary tuberculosis].
Monocytes/macrophages are the main effector cells as well as the essential elements in granuloma formation in tuberculosis. Serum concentration of some cytokines connected with monocytes/macrophages like IL-12, MCP-1, TNF-alpha i sTNFRI was assessed in patients with advanced bacteriologically confirmed pulmonary tuberculosis (I group) and in those with minimal tb changes, usually without clinical signs of the disease, and sputum smear-negative (II group). We found that patients from group I had significantly higher concentration of IL-12 and sTNFRI and lower level of MCP-1 in comparison to group II. Significant difference between groups of patients with tuberculosis and the control group was found only while assessing serum concentration of TNFRI.
Kwiatkowska
S
S
Kliniki Ftizjopneumonologii IMW AM w Lodzi.
Zieba
M
M
Kuźmińska
B
B
D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D018664:Interleukin-12 / Q000097:blood; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D011506:Proteins / Q000032:analysis; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D047990:TNF Receptor-Associated Factor 1; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000145:classification
D018932:Chemokine CCL2; D016207:Cytokines; D011506:Proteins; D018124:Receptors, Tumor Necrosis Factor; D047990:TNF Receptor-Associated Factor 1; D018664:Interleukin-12