A case of lichen planus-like keratosis: deposition of IgM in the basement membrane zone.
An 81-year-old woman presented with a round erythematous macule with keratotic scales on her left hand. The skin specimen histologically showed hypergranulosis and apoptotic keratinocytes in the epidermis with lichenoid infiltration of lymphocytes. Parakeratosis seen in the hyperkeratotic cornified layer indicated lichen planus-like keratosis, as distinguished from lichen planus. Direct immunofluorescence study revealed the linear deposition of IgM in the basement membrane zone; IgG, IgA and C3 were not detected.
Inui
S
S
Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University, Suita-shi, Japan.
Itami
S
S
Kobayashi
T
T
Yoshikawa
K
K
D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006229:Hand Dermatoses / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000302:isolation & purification*; D007642:Keratosis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008010:Lichen Planus / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
D007075:Immunoglobulin M