title: Management of fetal thyroid goitres: a report of 11 cases in a single perinatal unit.
abstract: Fetal thyroid goitres may reveal hormonal imbalance. This can jeopardize neurological development and fetal outcome even when early postnatal treatment is provided. We report a series of 11 goitres diagnosed antenatally in women with past or present thyroid disorders or discovered fortuitously on ultrasound scan. Fetuses presented with hyperthyroidism in three cases and hypothyroidism in eight. Hypothyroidism was iatrogenic in five cases, due to maternal anti-thyroid drugs. Hyperthyroidism was induced by transplacental transfer of thyroid stimulating antibodies (TSHrab). Accurate diagnosis of fetal thyroid status was obtained by fetal blood sampling but this invasive method was deemed necessary only in four cases as maternal clinical and biological data and ultrasound signs provided sufficient information to infer the type of thyroid disorder in the remaining patients. Fetal therapy relied on reduction of maternal antithyroid medication and, in selected cases, intra-amniotic injection of levothyroxin in hypothyroidism, and on administration of antithyroid drugs in hyperthyroidism. All newborns were healthy and none displayed consequences of severe thyroid imbalance. No caesarean section was performed for dystocia. Fetal thyroid goitres can be managed successfully with selected use of invasive diagnostic and therapeutic techniques.
authors.affiliation: Département de Périnatologie, Hôpital Robert Debré, 48 Bvd Serurier, 75019 Paris, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Volumenie
authors.forename: M
authors.initials: M
authors.lastname: Polak
authors.forename: J
authors.initials: J
authors.lastname: Guibourdenche
authors.forename: J F
authors.initials: JF
authors.lastname: Oury
authors.forename: E
authors.initials: E
authors.lastname: Vuillard
authors.forename: O
authors.initials: O
authors.lastname: Sibony
authors.forename: F
authors.initials: F
authors.lastname: Reyal
authors.forename: B
authors.initials: B
authors.lastname: Raccah-Tebeka
authors.forename: C
authors.initials: C
authors.lastname: Boissinot
authors.forename: A M
authors.initials: AM
authors.lastname: Madec
authors.forename: J
authors.initials: J
authors.lastname: Orgiazzi
authors.forename: M E
authors.initials: ME
authors.lastname: Toubert
authors.forename: J
authors.initials: J
authors.lastname: Leger
authors.forename: P
authors.initials: P
authors.lastname: Blot
authors.forename: D
authors.initials: D
authors.lastname: Luton
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000628:therapy*; D006042:Goiter / Q000196:embryology* / Q000628:therapy*; D006757:Hospital Units; D006801:Humans; D006980:Hyperthyroidism / Q000196:embryology / Q000209:etiology / Q000628:therapy; D007037:Hypothyroidism / Q000196:embryology / Q000209:etiology / Q000628:therapy; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D016216:Ultrasonography, Prenatal