title: Mother-to-child transmission of hepatitis C virus: evidence for preventable peripartum transmission.
abstract: BACKGROUND
  Little information is available about the timing of mother-to-child transmission of hepatitis C virus (HCV), and no interventions to decrease transmission rates have been identified. We examined the effect of risk factors, including mode of delivery, on the vertical transmission rate.
  
  
  METHODS
  Data from HCV-infected women and their infants from three hospitals in Ireland and from a British Paediatric Surveillance Unit study of infants born to HCV-infected mothers were used to estimate the vertical transmission rate and risk factors for transmission. We used a probabilistic model using methods that simultaneously estimated the time to HCV-antibody loss in uninfected infants and the diagnostic accuracy of PCR tests for HCV RNA.
  
  
  RESULTS
  441 mother-child pairs from the UK (227) and Ireland (214) were included. 50% of uninfected children became HCV-antibody negative by 8 months and 95% by 13 months. The estimated specificity of PCR for HCV RNA was 97% (95% CI 96-99) and was unrelated to age; sensitivity was only 22% (7-46) in the first month but rose sharply to 97% (85-100) thereafter. The vertical transmission rate was 6.7% (4.1-10.2) overall, and 3.8 times higher in HIV coinfected (n=22) than in HIV-negative women after adjustment for other factors (p=0.06). No effect of breastfeeding on transmission was observed, although only 59 women breastfed. However, delivery by elective caesarean section before membrane rupture was associated with a lower transmission risk than vaginal or emergency caesarean-section delivery (odds ratio 0 [0-0.87], p=0.04, after adjustment for other factors).
  
  
  CONCLUSIONS
  The low sensitivity of HCV RNA soon after birth and the finding of a lower transmission rate after delivery by elective caesarean section suggest that HCV transmission occurs predominantly around the time of delivery. If the findings on elective caesarean section are confirmed in other studies, the case for antenatal HCV testing should be reconsidered.
authors.affiliation: Medical Research Council Clinical Trials Unit, London, UK. D.Gibb@ctu.mrc.ac.uk
authors.forename: D M
authors.initials: DM
authors.lastname: Gibb
authors.forename: R L
authors.initials: RL
authors.lastname: Goodall
authors.forename: D T
authors.initials: DT
authors.lastname: Dunn
authors.forename: M
authors.initials: M
authors.lastname: Healy
authors.forename: P
authors.initials: P
authors.lastname: Neave
authors.forename: M
authors.initials: M
authors.lastname: Cafferkey
authors.forename: K
authors.initials: K
authors.lastname: Butler
mesh_terms: D000367:Age Factors; D001942:Breast Feeding; D002585:Cesarean Section; D015331:Cohort Studies; D016001:Confidence Intervals; D036861:Delivery, Obstetric; D017558:Elective Surgical Procedures; D005260:Female; D016174:Hepacivirus / Q000145:classification / Q000235:genetics; D006526:Hepatitis C / Q000517:prevention & control / Q000635:transmission*; D018937:Hepatitis C Antibodies / Q000032:analysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D007494:Ireland; D016017:Odds Ratio; D011336:Probability; D012367:RNA, Viral / Q000032:analysis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D006113:United Kingdom
chemical_list: D018937:Hepatitis C Antibodies; D012367:RNA, Viral