Isolation and characterization of tetracycline-resistant clinical isolates of Helicobacter pylori.
Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 microgram/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracycline-resistant isolates exhibited cross-resistance to metronidazole, and the cross-resistance was transferred to tetracycline-sensitive H. pylori strains.
Kwon
D H
DH
Department of Medicine, Baylor College of Medicine, and Veterans Affairs Medical Center, Houston, Texas 77030, USA. dkwon@bcm.tmc.edu
Kim
J J
JJ
Lee
M
M
Yamaoka
Y
Y
Kato
M
M
Osato
M S
MS
El-Zaatari
F A
FA
Graham
D Y
DY
D018432:Drug Resistance, Multiple; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D007723:Korea; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013752:Tetracycline / Q000494:pharmacology*; D013753:Tetracycline Resistance / Q000502:physiology*
D008795:Metronidazole; D013752:Tetracycline