title: Paraoxonase polymorphisms, pesticide exposure and Parkinson's disease in a Caucasian population.
abstract: Parkinson's disease (PD) has been associated with exposure to pesticides and oxidative injury. The involvement of paraoxonase in both pesticide metabolism and lipid peroxidation suggests that it may play a role in the pathogenesis of PD. We examined the frequency of polymorphic alleles of the PON1 and PON2 genes in a sample of caucasian subjects with PD. The frequency distribution of these genotypes did not differ significantly between patients and controls, including those who had reported exposure to pesticides.
authors.affiliation: Molecular Genetics Group, John Curtin School of Medical Research, Acton, ACT, Australia.
authors.forename: M C
authors.initials: MC
authors.lastname: Taylor
authors.forename: D G
authors.initials: DG
authors.lastname: Le Couteur
authors.forename: G D
authors.initials: GD
authors.lastname: Mellick
authors.forename: P G
authors.initials: PG
authors.lastname: Board
mesh_terms: D043303:Aryldialkylphosphatase; D004781:Environmental Exposure; D004950:Esterases / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009517:New South Wales; D010300:Parkinson Disease / Q000235:genetics*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D010575:Pesticides / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D011793:Queensland; D044465:White People / Q000235:genetics
chemical_list: D010575:Pesticides; D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C468411:PON2 protein, human