Suppression of posttreatment recurrence of experimental visceral Leishmaniasis in T-cell-deficient mice by oral miltefosine.
T-cell-deficient nude mice infected with Leishmania donovani were treated with miltefosine and then given either no treatment or intermittent miltefosine. Intracellular visceral infection recurred in untreated mice but was suppressed by once- or twice-weekly oral administration of miltefosine. Miltefosine may be useful as oral maintenance therapy for T-cell-deficient patients with visceral leishmaniasis.
Murray
H W
HW
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA. hwmurray@mail.med.cornell.edu
D000284:Administration, Oral; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007893:Leishmania donovani; D007898:Leishmaniasis, Visceral / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D055502:Secondary Prevention; D013601:T-Lymphocytes / Q000276:immunology*
D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine