Neurokinin mediation of edema and inflammation.
The aim of this article is to furnish a brief review of the role played by neurokinins in the inflammatory process. Further attention is given to the mechanisms, as well as to the receptor subtypes involved in neurokinin-mediated inflammation, in an attempt to clarify the participation of neurokinins in different models of acute and chronic inflammation. The involvement of SP, NKA and NKB is also examined in relation to the major signs of inflammation, including edema formation, protein plasma extravasation and vasodilatation. Finally, we provide a general overview on the potential clinical applications of neurokinin antagonists, along with the involvement of neurokinins in human diseases.
Campos
M M
MM
Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, 88015-420 &ndash, Florianópolis, SC, Brazil.
Calixto
J B
JB
D000818:Animals; D004487:Edema / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D015288:Neurokinin A / Q000378:metabolism; D015287:Neurokinin B / Q000378:metabolism; D013373:Substance P / Q000378:metabolism; D015320:Tachykinins / Q000378:metabolism*
D015320:Tachykinins; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B