title: Chronic neutrophilic leukemia with acute myeloblastic transformation.
abstract: We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and mu, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene.
authors.affiliation: Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Katsuki
authors.forename: K
authors.initials: K
authors.lastname: Shinohara
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Ariyoshi
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: N
authors.initials: N
authors.lastname: Kameda
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: R
authors.initials: R
authors.lastname: Nawata
authors.forename: S
authors.initials: S
authors.lastname: Shibata
authors.forename: Y
authors.initials: Y
authors.lastname: Asano
authors.forename: S
authors.initials: S
authors.lastname: Okamura
mesh_terms: D000368:Aged; D001752:Blast Crisis / Q000235:genetics / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D015321:Gene Rearrangement; D006801:Humans; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics / Q000473:pathology*; D008297:Male; D010677:Philadelphia Chromosome; D012333:RNA, Messenger / Q000235:genetics; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016044:Fusion Proteins, bcr-abl