title: The genomic RNA in Ty1 virus-like particles is dimeric.
abstract: The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized during the proteolytic maturation of the particle. The stabilization of the dimer suggests that one of the cleavage products of TyA1 possesses nucleic acid chaperone activity.
authors.affiliation: HIV Drug Resistance Program, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201, USA.
authors.forename: Y X
authors.initials: YX
authors.lastname: Feng
authors.forename: S P
authors.initials: SP
authors.lastname: Moore
authors.forename: D J
authors.initials: DJ
authors.lastname: Garfinkel
authors.forename: A
authors.initials: A
authors.lastname: Rein
mesh_terms: D019281:Dimerization; D016679:Genome, Viral; D012367:RNA, Viral / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D018626:Retroelements; D014771:Virion / Q000737:chemistry* / Q000235:genetics
chemical_list: D012367:RNA, Viral; D018626:Retroelements