title: Investigation of the relationship between low Apgar scores and early neonatal thyroid function.
abstract: BACKGROUND
  The aim of the present study was to assess the effects of low Apgar scores on perinatal thyroid function.
  
  
  METHODS
  Forty full-term infants delivered by the normal spontaneous vaginal route were enrolled into the study. All babies had 1 and 5 min Apgar scores below 4. The control group consisted of 26 full-term healthy neonates. Cord blood and serum tri-iodothyronine (T3), thyroxine (T4), reverse tri-iodothyronine (rT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH) and thyroid-binding globulin (TBG) determinations were performed by an enzyme immunoassay method.
  
  
  RESULTS
  The mean values of FT4 and T4 observed in the cord blood of the study group were significantly lower compared with matched controls, whereas the mean TSH values were significantly higher. There were no differences in concentrations of T3, rT3 and TBG between the two groups.
  
  
  CONCLUSIONS
  These results demonstrate the existence of transient hypothyroidism at birth in babies with Apgar scores below 4 delivered by the spontaneous vaginal route.
authors.affiliation: Department of Pediatrics, Zeynep Kamil Hospital, Istanbul, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Sak
authors.forename: M
authors.initials: M
authors.lastname: Akin
authors.forename: Z
authors.initials: Z
authors.lastname: Aktürk
authors.forename: F
authors.initials: F
authors.lastname: Akin
authors.forename: E
authors.initials: E
authors.lastname: Atay
authors.forename: C
authors.initials: C
authors.lastname: Aydogdu
authors.forename: E
authors.initials: E
authors.lastname: Yüzkollar
mesh_terms: D001034:Apgar Score; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis*; D007231:Infant, Newborn / Q000097:blood; D013961:Thyroid Gland / Q000502:physiology; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D013963:Thyroid Hormones