Anti-plakin and desmoglein autoantibodies in a dog with pemphigus vulgaris.
Paraneoplastic pemphigus was suspected in a 14-year-old Labrador retriever because of mucocutaneous erosions, microscopic suprabasal acantholysis, and keratinocyte apoptosis. In this patient, circulating IgG autoantibodies recognized plakin (envoplakin, periplakin) and desmoglein (desmoglein-1 and -3) antigens. Necropsy, however, failed to confirm the concurrent existence of hematopoietic or solid neoplasia. The diagnosis of pemphigus vulgaris therefore was proposed. This study illustrates that such a combination of clinicopathologic lesions and plakin/desmoglein-specific autoantibodies is not restricted to canine paraneoplastic pemphigus but can also be detected in another form of suprabasal pemphigus.
Olivry
T
T
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA. Thierry_Olivry@ncsu.edu
Alhaidari
Z
Z
Ghohestani
R F
RF
D000818:Animals; D017209:Apoptosis; D001323:Autoantibodies / Q000032:analysis*; D003598:Cytoskeletal Proteins / Q000276:immunology*; D051183:Desmoglein 1; D051182:Desmogleins; D051180:Desmoplakins; D004283:Dog Diseases / Q000276:immunology*; D004285:Dogs; D005065:Euthanasia / Q000662:veterinary; D007074:Immunoglobulin G / Q000032:analysis; D015603:Keratinocytes / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D010392:Pemphigus / Q000276:immunology / Q000662:veterinary*; D011498:Protein Precursors / Q000276:immunology*
D001323:Autoantibodies; D003598:Cytoskeletal Proteins; D051183:Desmoglein 1; D051182:Desmogleins; D051180:Desmoplakins; D007074:Immunoglobulin G; D008565:Membrane Proteins; D011498:Protein Precursors; C100754:envoplakin