Circulating hepatocyte growth factor as a marker of thrombus formation in unstable angina pectoris.
A new enzyme-linked immunosorbent assay can detect 10 pg/ml of human hepatocyte growth factor (HGF). Circulating HGF was significantly higher in patients with unstable angina (296+/-184 pg/ml, mean+/-SD, n=36) than in healthy volunteers (201+/-64 pg/ml, n=250, p<0.0001). Individual concentrations exceeded the mean control value +2 SD (329 pg/ml) in 12 of the 36 (33%) patients with unstable angina. The present study indicates that this new, sensitive HGF assay can successfully detect thrombosis in patients with unstable angina.
Matsumori
A
A
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan. amat@kuhp.kyoto-u.ac.jp
Miyazaki
S
S
Takano
H
H
Ono
K
K
Okada
M
M
Miyamoto
T
T
Nonogi
H
H
Daikoku
S
S
Mitsudo
K
K
Matsunaga
Y
Y
Ohnishi
T
T
Daikuhara
Y
Y
Sasayama
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D003328:Coronary Thrombosis / Q000097:blood / Q000175:diagnosis*; D003402:Creatine Kinase / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020107:Troponin T / Q000097:blood
D015415:Biomarkers; D020107:Troponin T; D017228:Hepatocyte Growth Factor; D003402:Creatine Kinase