[Influence of pre-infarction angina on mid-term mortality after acute myocardial infarction].
OBJECTIVE
Pre-infarction angina may reduce the extent of myocardial cell necrosis and improves the prognosis after myocardial infarction. The aim of this study was to analyze the total mortality six-month after acute myocardial infarction according to the presence or absence of pre-infarction angina.


METHODS
One hundred seventy-five consecutive patients with acute myocardial infarction were prospectively included, 72 (41.4%) with pre-infarction angina. They were followed for 6 months. There were 16 deaths (15.5%) in the group of patients without pre-infarction angina and 7 (9.7%) in the group with pre-infarction angina (log-rank = 1.03; p = 0.311). The hazard-risk function curves showed a higher risk of death during the entire follow-up in the group without pre-infarction angina. In the multivariate logistic regression model, the presence of pre-infarction angina does not significantly reduce the risk of death (OR = 0.43; CI 95% = 0.09-2. 22; p = 0.303). We detected a significant interaction between treatment with sulfonylureas before the infarction and the presence of pre-infarction angina (p = 0.017).


CONCLUSIONS
In this study no significant differences were observed in total mortality six months after acute myocardial infarction according to the presence of pre-infarction angina. However, the risk of death seemed to be higher in the group of patients without pre-infarction angina during the entire follow-up. A significant interaction was found between the treatment with sulfonylurea drugs before infarction and the presence of pre-infarction angina.
Iglesias Garriz
I
I
Servicio de Cardiología. Hospital de León. med016340@nacom.es
Sastre Ibarretxe
M
M
Delgado Fernández
S
S
Garrote Coloma
C
C
Corral Fernández
F
F
Montes Montes
M
M
Rodríguez García
M A
MA
D000368:Aged; D000787:Angina Pectoris / Q000150:complications*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000401:mortality*; D011446:Prospective Studies; D013997:Time Factors