title: Relationship between clinical signs and lung function in horses with recurrent airway obstruction (heaves) during a bronchodilator trial.
abstract: During a trial to determine the dose response to the beta2-adrenergic agonist pirbuterol, we judged the severity of airway obstruction by use of a clinical scoring system and compared this to objective data obtained by quantitative measures of lung function. Six horses affected by recurrent airway obstruction were used in this trial. Four hundred and sixty-eight measurements of lung function and clinical scores were obtained from 13 measurement periods when horses received each of 6 doses of pirbuterol. Scores of 1-4 were assigned to degree of nasal flaring and abdominal effort and summed for a total score. The veterinarian scoring the signs did not know the dose of pirbuterol received by the horse and was unaware of the lung function data. Nasal, abdominal and total scores were significantly related to changes in lung function and changes in breathing pattern. There were significant differences between total scores greater than 5 in indices that reflected changes in breathing strategy (peak inspiratory and expiratory flow), peripheral airway obstruction (dynamic elastance), and effort of breathing (maximal change in pleural pressure). Below a total score of 5, there were fewer significant differences in lung function even though measurements of pulmonary resistance and dynamic elastance indicated considerable airway obstruction. Failure of clinical score to reflect this low-grade airway obstruction suggests that airway disease is underdiagnosed and its detection would be helped by the availability of a convenient lung function test.
authors.affiliation: Pulmonary Laboratory, Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824-1314, USA.
authors.forename: N E
authors.initials: NE
authors.lastname: Robinson
authors.forename: M A
authors.initials: MA
authors.lastname: Olszewski
authors.forename: D
authors.initials: D
authors.lastname: Boehler
authors.forename: C
authors.initials: C
authors.lastname: Berney
authors.forename: J
authors.initials: J
authors.lastname: Hakala
authors.forename: C
authors.initials: C
authors.lastname: Matson
authors.forename: F J
authors.initials: FJ
authors.lastname: Derksen
mesh_terms: D000402:Airway Obstruction / Q000503:physiopathology / Q000662:veterinary*; D000818:Animals; D001993:Bronchodilator Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000008:administration & dosage; D005260:Female; D006734:Horse Diseases / Q000503:physiopathology*; D006736:Horses; D008168:Lung / Q000503:physiopathology*; D008297:Male; D012129:Respiratory Function Tests / Q000662:veterinary; D012130:Respiratory Hypersensitivity / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D001993:Bronchodilator Agents; D004983:Ethanolamines; C009118:pirbuterol