title: Cerebral hemodynamics during arterial and CO(2) pressure changes: in vivo prediction by a mathematical model.
abstract: The aim of this work was to analyze changes in cerebral hemodynamics and intracranial pressure (ICP) evoked by mean systemic arterial pressure (SAP) and arterial CO(2) pressure (Pa(CO(2))) challenges in patients with acute brain damage. The study was performed by means of a new simple mathematical model of intracranial hemodynamics, particularly aimed at routine clinical investigation. The model was validated by comparing its results with data from transcranial Doppler velocity in the middle cerebral artery (V(MCA)) and ICP measured in 44 tracings on 13 different patients during mean SAP and Pa(CO(2)) challenges. The validation consisted of individual identification of 6 parameters in all 44 tracings by means of a best fitting algorithm. The parameters chosen for the identification summarize the main aspects of intracranial dynamics, i.e., cerebrospinal fluid circulation, intracranial elastance, and cerebrovascular control. The results suggest that the model is able to reproduce the measured time patterns of V(MCA) and ICP in all 44 tracings by using values for the parameters that lie within the ranges reported in the pathophysiological literature. The meaning of parameter estimates is discussed, and comments on the main virtues and limitations of the present approach are offered.
authors.affiliation: Department of Electronics, Computer Science and Systems, University of Bologna, I-40136 Bologna, Italy. mursino@deis.unibo.it
authors.forename: M
authors.initials: M
authors.lastname: Ursino
authors.forename: A
authors.initials: A
authors.lastname: Ter Minassian
authors.forename: C A
authors.initials: CA
authors.lastname: Lodi
authors.forename: L
authors.initials: L
authors.lastname: Beydon
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood*; D002560:Cerebrovascular Circulation; D016489:Head Injuries, Closed / Q000097:blood / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D016018:Least-Squares Analysis; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging; D008955:Models, Cardiovascular; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D002245:Carbon Dioxide