Hydrolysis of lysergamide to lysergic acid by Rhodococcus equi A4.
From a mixture of lysergamide and its epimer isolysergamide, Rhodococcus equi A4 containing amidase preferentially hydrolyzed lysergamide into lysergic acid.
Martínková
L
L
Laboratory of Biotransformation, Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídenská 1083, CZ-142 20 4, Prague, Czech Republic. martinko@biomed.cas.cz
Kren
V
V
Cvak
L
L
Ovesná
M
M
Prepechalová
I
I
D000581:Amidohydrolases / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D002967:Claviceps / Q000201:enzymology; D004874:Ergonovine / Q000378:metabolism; D006868:Hydrolysis; D008237:Lysergic Acid / Q000737:chemistry / Q000378:metabolism*; D008238:Lysergic Acid Diethylamide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D016929:Rhodococcus equi / Q000201:enzymology*; D013237:Stereoisomerism
C016543:lysergamide; C040195:lysergic acid alpha-hydroxyethylamide; D008238:Lysergic Acid Diethylamide; D000581:Amidohydrolases; D008237:Lysergic Acid; D004874:Ergonovine