title: Decoding calcium signals involved in cardiac growth and function.
abstract: Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.
authors.affiliation: Department of Molecular Biology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.
authors.forename: N
authors.initials: N
authors.lastname: Frey
authors.forename: T A
authors.initials: TA
authors.lastname: McKinsey
authors.forename: E N
authors.initials: EN
authors.lastname: Olson
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology; D006332:Cardiomegaly / Q000503:physiopathology; D005786:Gene Expression Regulation; D006321:Heart / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*
chemical_list: D002147:Calmodulin