title: Isolation and characterization of tetracycline-resistant clinical isolates of Helicobacter pylori.
abstract: Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 microgram/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracycline-resistant isolates exhibited cross-resistance to metronidazole, and the cross-resistance was transferred to tetracycline-sensitive H. pylori strains.
authors.affiliation: Department of Medicine, Baylor College of Medicine, and Veterans Affairs Medical Center, Houston, Texas 77030, USA. dkwon@bcm.tmc.edu
authors.forename: D H
authors.initials: DH
authors.lastname: Kwon
authors.forename: J J
authors.initials: JJ
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: M S
authors.initials: MS
authors.lastname: Osato
authors.forename: F A
authors.initials: FA
authors.lastname: El-Zaatari
authors.forename: D Y
authors.initials: DY
authors.lastname: Graham
mesh_terms: D018432:Drug Resistance, Multiple; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007564:Japan; D007723:Korea; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013752:Tetracycline / Q000494:pharmacology*; D013753:Tetracycline Resistance / Q000502:physiology*
chemical_list: D008795:Metronidazole; D013752:Tetracycline