[Pharmacological study on the compatibility of cortex Cinnamomi with Halloysitum Rubrum].
The decoction of Cortex Cinnamomi (CC, 1 g/kg p.o.) and Halloysitum Rubrum (HR, 3 g/kg p.o.) or the combination of the two drugs (4 g/kg p.o., CC 1 g/kg, HR 3 g/kg) could antagonize the diarrhea caused by p.o. water ex tract of Radix et Rhizoma Rhei in mice; and inhibit the platelet aggregation induced by ADP in vitro. Meanwhile, the effect of the combination of the two drugs was not different from that of each single one. In addition, CC was able to inhibit the spontaneous movement of intestine in situ and showed an analgesic effect (hot-plate method) in mice; HR was ineffective in these aspects and did not reduce the effect of CC. CC(20 g/kg p.o., i.p. or i.v.) exhibited very strong toxicity in mice, while HR(60 g/kg p.o., i.p. or i.v.) was nontoxic. When the two drugs were used together, the toxicity was markedly reduced.
Yu
Z
Z
China Pharmaceutical University, Nanjing.
Zhang
G
G
Dai
Y
Y
Kou
J
J
Dou
C
C
Lu
R
R
D000538:Aluminum Silicates / Q000494:pharmacology* / Q000633:toxicity; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology; D003967:Diarrhea / Q000188:drug therapy; D004344:Drug Incompatibility; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D019770:Lauraceae; D008297:Male; D008419:Materia Medica / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits
D000538:Aluminum Silicates; D000700:Analgesics; D000930:Antidiarrheals; D004365:Drugs, Chinese Herbal; D008419:Materia Medica