In vitro susceptibilities of 11 clinical isolates of Exophiala species to six antifungal drugs.
The antifungal activities of miconazole, terbinafine, itraconazole, UR 9825, voriconazole and amphotericin B against 11 clinical isolates of Exophiala spp. were tested by the broth microdilution method. All drugs were very active against Exophiala spp.. The 90% minimal inhibitory concentration (MIC90) ranged from 0.125 to 1 microgram ml-1. Terbinafine was the most active drug against Exophiala spinifera, Exophiala dermatitidis and Exophiala castellanii and seems to be a promising agent in the treatment of infections caused by these fungi.
Meletiadis
J
J
Department of Medical Microbiology, University Hospital Nijmegen, The Netherlands. j.meletiadis@mmb.azn.nl
Meis
J F
JF
de Hoog
G S
GS
Verweij
P E
PE
D000935:Antifungal Agents / Q000494:pharmacology*; D005093:Exophiala / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology*
D000935:Antifungal Agents