Impact of a new quinolone, DU-6859a, and two oral carbapenems, CS-834 and L-084, on the rat and mouse caecal microflora.
We determined the influence of a new quinolone, DU-6859a, and two oral carbapenems, CS-834 and L-084, on the rat and mouse caecal microflora. The caecum-skin fistula-implanted rats and conventional mice were given oral antimicrobials at doses of 30 mg/kg bid for 5 days. DU-6859a generated a marked decrease in the numbers of caecal flora except for enterococci. CS-834 and L-084 had little impact on the rat caecal flora. CS-834 caused a great decrease in the numbers of mouse caecal flora but L-084 did not. In vitro studies suggest that the difference is due to the extension of inactivation of antimicrobials by caecum contents.
Liu
C X
CX
Institute of Anaerobic Bacteriology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan.
Kato
N
N
Watanabe
K
K
Sakata
T
T
Kaneko
T
T
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D015780:Carbapenems / Q000494:pharmacology*; D002432:Cecum / Q000382:microbiology*; D024841:Fluoroquinolones; D008297:Male; D051379:Mice; D011355:Prodrugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000890:Anti-Infective Agents; D015780:Carbapenems; D024841:Fluoroquinolones; D011355:Prodrugs; C120999:L 084; C076246:sitafloxacin; C107030:CS 834