title: Dose response of laboratory markers to alcohol consumption in a general population.
abstract: The dose response to alcohol use of carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and their combination (gamma-CDT) was studied in an age- and gender-stratified, random sample from Finland in 1997. A linear association with a threshold between alcohol consumption and the three markers was observed. Body mass index was negatively associated with CDT and positively with GGT Age was positively associated with GGT and gamma-CDT In conclusion, CDT appears to be an early phase marker of alcohol consumption. The combined marker, gamma-CDT, was less associated with factors such as body mass index but more strongly correlated with alcohol consumption than were the two markers separately.
authors.affiliation: Alcohol-related Diseases, Pharmacia & Upjohn Diagnostics AB, Uppsala, Sweden. Pekka.Sillanaukee@finnish-immunotech.com
authors.forename: P
authors.initials: P
authors.lastname: Sillanaukee
authors.forename: N
authors.initials: N
authors.lastname: Massot
authors.forename: P
authors.initials: P
authors.lastname: Jousilahti
authors.forename: E
authors.initials: E
authors.lastname: Vartiainen
authors.forename: J
authors.initials: J
authors.lastname: Sundvall
authors.forename: U
authors.initials: U
authors.lastname: Olsson
authors.forename: K
authors.initials: K
authors.lastname: Poikolainen
authors.forename: M
authors.initials: M
authors.lastname: Pönniö
authors.forename: J P
authors.initials: JP
authors.lastname: Allen
authors.forename: H
authors.initials: H
authors.lastname: Alho
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000378:metabolism*; D015415:Biomarkers; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D012907:Smoking; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; D005723:gamma-Glutamyltransferase