title: Novel antihyperglycemic terpenoid-quinones from Pycnanthus angolensis.
abstract: Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity.
authors.affiliation: Shaman Pharmaceuticals Inc., South San Francisco, California 94080-4812, USA. dfort@pharmanex.com
authors.forename: D M
authors.initials: DM
authors.lastname: Fort
authors.forename: R P
authors.initials: RP
authors.lastname: Ubillas
authors.forename: C D
authors.initials: CD
authors.lastname: Mendez
authors.forename: S D
authors.initials: SD
authors.lastname: Jolad
authors.forename: W D
authors.initials: WD
authors.lastname: Inman
authors.forename: J R
authors.initials: JR
authors.lastname: Carney
authors.forename: J L
authors.initials: JL
authors.lastname: Chen
authors.forename: T T
authors.initials: TT
authors.lastname: Ianiro
authors.forename: C
authors.initials: C
authors.lastname: Hasbun
authors.forename: R C
authors.initials: RC
authors.lastname: Bruening
authors.forename: J
authors.initials: J
authors.lastname: Luo
authors.forename: M J
authors.initials: MJ
authors.lastname: Reed
authors.forename: M
authors.initials: M
authors.lastname: Iwu
authors.forename: T J
authors.initials: TJ
authors.lastname: Carlson
authors.forename: S R
authors.initials: SR
authors.lastname: King
authors.forename: D E
authors.initials: DE
authors.lastname: Bierer
authors.forename: R
authors.initials: R
authors.lastname: Cooper
mesh_terms: D000349:Africa; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003920:Diabetes Mellitus / Q000097:blood / Q000235:genetics; D004435:Eating / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D005231:Fatty Acids, Unsaturated; D007004:Hypoglycemic Agents; D009285:Naphthoquinones; D010936:Plant Extracts; C416066:pycnanthuquinone A