title: Methylene blue-induced hyperbilirubinemia in neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency.
abstract: Methylene blue continues to be used in the gravid female. We report three premature neonates exposed to methylene blue that experienced severe hemolytic reactions requiring exchange transfusions. Two neonates were subsequently diagnosed with G6PD deficiency. Continued caution is warranted prior to the use of methylene blue in the gravid female.
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA. tgauthi@emory.edu
authors.forename: T W
authors.initials: TW
authors.lastname: Gauthier
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications; D004396:Coloring Agents / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications*; D006801:Humans; D006932:Hyperbilirubinemia / Q000139:chemically induced* / Q000628:therapy; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000628:therapy; D008297:Male; D008751:Methylene Blue / Q000009:adverse effects*; D011247:Pregnancy; D002581:Uterine Cervical Incompetence / Q000150:complications
chemical_list: D004396:Coloring Agents; D004791:Enzyme Inhibitors; D005954:Glucosephosphate Dehydrogenase; D008751:Methylene Blue