title: Marked and prompt hemodynamic improvement by carperitide in refractory congestive heart failure due to dilated cardiomyopathy.
abstract: A 16-year-old Japanese male diagnosed with congestive heart failure (CHF) due to dilated cardiomyopathy was treated by conventional intensive treatment such as intravenous infusion of diuretics, catecholamines, and phosphodiesterase inhibitors with vasodilators. However, he developed a low output syndrome with appearances of hyponatremia and hypochloremia. As a consequence, intravenous infusion of carperitide (synthetic atrial natriuretic peptide) was added to the therapy. Thereafter his symptoms and hemodynamic parameters promptly and dramatically improved without significant diuresis, and this amelioration persisted for more than 20 days without drug intolerance. This outcome suggests that use of carperitide may be a safe and efficacious means to reduce cardiac preload without hypotension and tachycardia in patients with refractory CHF in whom intensive treatment has already been performed.
authors.affiliation: Second Department of Internal Medicine, School of Medicine, Iwate Medical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Ohira
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: K I
authors.initials: KI
authors.lastname: Fukami
authors.forename: K
authors.initials: K
authors.lastname: Hiramori
mesh_terms: D000293:Adolescent; D009320:Atrial Natriuretic Factor / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000150:complications*; D004232:Diuretics / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010446:Peptide Fragments / Q000627:therapeutic use*
chemical_list: D001993:Bronchodilator Agents; D004232:Diuretics; D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor