title: The use of ascorbigen in the treatment of fibromyalgia patients: a preliminary trial.
abstract: Twelve female fibromyalgia syndrome (FMS) patients were given 500 mg per day of a blend containing 100 mg ascorbigen and 400 mg broccoli powder in a preliminary, one-month, open-label trial. This group of patients showed a mean 20.1 percent (p=0.044) decrease in their physical impairment score and a mean 17.8 percent (p=0.016) decrease in their total fibromyalgia impact scores as measured by the Fibromyalgia Impact Questionnaire. The mean physical impairment score two weeks post-treatment showed a significant return to near pre-treatment level (p=0.028). Analysis of ten of the patients' mean threshold pain levels at the 18 possible tender points obtained before and at the end of treatment showed a strong trend toward an increase in the mean threshold pain level (p=0.059). The reduced sensitivity to pain and improvement in quality of life measured in this study appear to be clinically relevant and a larger, double-blind study is warranted.
authors.affiliation: National College of Naturopathic Medicine, USA. benandnanette@juno.com
authors.forename: B
authors.initials: B
authors.lastname: Bramwell
authors.forename: S
authors.initials: S
authors.lastname: Ferguson
authors.forename: N
authors.initials: N
authors.lastname: Scarlett
authors.forename: A
authors.initials: A
authors.lastname: Macintosh
mesh_terms: D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D001937:Brassica / Q000627:therapeutic use; D005260:Female; D005356:Fibromyalgia / Q000188:drug therapy*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D017288:Pain Threshold; D008517:Phytotherapy; D011795:Surveys and Questionnaires
chemical_list: D007211:Indoles; C053152:ascorbigen; D001205:Ascorbic Acid