title: Routine screening for Chlamydia trachomatis in subfertile women--is it time to start?
abstract: Genital Chlamydia trachomatis infection has long been recognised as the major cause of pelvic disease and subsequently infertility. The diagnosis of this infection has traditionally relied on tissue culture. The availability of DNA amplification methods like ligase chain reaction promises faster and more sensitive results. This study was conducted to evaluate the prevalence of chlamydial infection in a subfertile population subgroup.
  
  
  OBJECTIVE
  A case control longitudinal study of 100 subfertile women in a tertiary teaching hospital were analyzed for the prevalence of genital Chlamydia trachomatis infection using ligase chain reaction test kit.
  
  
  RESULTS
  A prevalence rate of 8% was detected, the majority being 25 years old or less (33.3%), p = 0.007. All patients gave no prior history of abnormal PAP smears, hospitalisation for pelvic inflammatory disease or abnormal vaginal discharge at the time of investigation.
  
  
  CONCLUSIONS
  Our infertile group of patients has a relatively high incidence of silent genital Chlamydia trachomatis infection. This being highest in the below 25 years old age group. This finding indicates that screening for chlamydia may be necessary for the subfertile couple presenting to clinic. This is especially so if the patient is of the younger age group.
authors.affiliation: Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore.
authors.forename: C T
authors.initials: CT
authors.lastname: Yeong
authors.forename: T L
authors.initials: TL
authors.lastname: Lim
authors.forename: R
authors.initials: R
authors.lastname: Lin
authors.forename: S Y
authors.initials: SY
authors.lastname: Se Thoe
authors.forename: N
authors.initials: N
authors.lastname: Leong
mesh_terms: D000328:Adult; D002690:Chlamydia Infections / Q000150:complications / Q000175:diagnosis*; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007247:Infertility, Female / Q000150:complications*; D022521:Ligase Chain Reaction; D011247:Pregnancy