Changes in QT dispersion during adenosine infusion.
BACKGROUND
QT dispersion (QTd) measurement during treadmill stress testing has been to shown to improve the accuracy of exercise electrocardiogram (ECG) in the detection of significant coronary artery disease (CAD).


OBJECTIVE
The aim of this study was to determine whether adenosine-induced changes in QTd could predict significant CAD and to assess its efficacy as a diagnostic index in patients undergoing adenosine stress test.


METHODS
QT interval measurements were made in 57 consecutive patients undergoing adenosine sestamibi stress test. Patients with an abnormal stress test underwent coronary angiography. Patients with significant disease by coronary angiography (> 70% stenosis) were classified as having CAD (Group 1), and those with normal stress images and/or normal coronaries by angiography were classified as having no CAD (Group 2).


RESULTS
QT dispersion increased from 28.2 +/- 4.5 to 43.8 +/- 4.5 ms with a delta QTd of 15.53 +/- 3.68 in Group 1 (p = 0.001) and from 28.4 +/- 2.6 to 34.8 +/- 2.8 ms with a delta QTd of 6.58 +/- 2.21 ms in Group 2 (p = 0.006). Patients in Group 1 had a significantly higher increase in QTd (delta QTd) than the patients in Group 2 (p < 0.03). Addition of delta QTd (> 10 ms) to the ST depression during adenosine infusion would increase the sensitivity of the ECG from 23 to 65% and decrease the specificity from 91 to 70% for diagnosis of significant CAD.


CONCLUSIONS
delta QTd is significantly more prolonged in patients with CAD during adenosine infusion. It increases the sensitivity of the stress ECG in diagnosis of CAD during adenosine infusion when used as an adjuvant index.
Kumar
A
A
Dept. of Cardiology, Michael Reese Hospital, Chicago, IL 60616, USA.
Narasimhan
C
C
Sankari
A
A
Ranginani
A
A
Lennon
C
C
Bekerman
C
C
Clark
W
W
Denes
P
P
D000241:Adenosine / Q000008:administration & dosage; D000368:Aged; D003327:Coronary Disease / Q000175:diagnosis; D004562:Electrocardiography / Q000187:drug effects* / Q000379:methods / Q000706:statistics & numerical data; D005080:Exercise Test / Q000187:drug effects / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi / Q000008:administration & dosage; D013997:Time Factors; D014665:Vasodilator Agents / Q000008:administration & dosage
D014665:Vasodilator Agents; D017256:Technetium Tc 99m Sestamibi; D000241:Adenosine