title: Differential somato-dendritic localization of TrkA, TrkB, TrkC and p75 mRNAs in vivo.
abstract: TrkB mRNA was shown to be localized in the somatodendritic compartment in vitro but no data are currently available on the subcellular distribution of the neurotrophin receptors mRNAs in vivo. Here we describe the subcellular distribution of TrkA, TrkB, TrkC and p75 mRNAs in the adult rat basal forebrain. We find that TrkA, TrkC and p75 mRNAs are restricted to the cell soma but in addition, p75 mRNA labelling extends in average for 8 microm within the proximal dendrites of 34% of the labelled neurons. TrkB mRNA has a somatodendritic distribution in 95% of the labelled neurons reaching variable distances in different neurons (23-84.5 microm) and forebrain regions (mean: 40, 51 and 55 microm for diagonal band, septum and ventral pallidum).
authors.affiliation: BRAIN Centre for Neuroscience, Department of Biology, University of Trieste, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Tongiorgi
authors.forename: M
authors.initials: M
authors.lastname: Armellin
authors.forename: A
authors.initials: A
authors.lastname: Cattaneo
mesh_terms: D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology*; D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D005917:Globus Pallidus / Q000166:cytology / Q000378:metabolism; D017403:In Situ Hybridization; D008297:Male; D016548:Prosencephalon / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020800:Receptor, Nerve Growth Factor / Q000235:genetics*; D020917:Receptor, trkA / Q000235:genetics*; D020813:Receptor, trkB / Q000235:genetics*; D020812:Receptor, trkC / Q000235:genetics*; D012686:Septal Nuclei / Q000166:cytology / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D020800:Receptor, Nerve Growth Factor; D020917:Receptor, trkA; D020813:Receptor, trkB; D020812:Receptor, trkC