Antenatal and early postnatal dexamethasone treatment decreases cortisol secretion in preterm infants.
Glucocorticoids are used antenatally to accelerate the maturation of fetal respiratory and cardiovascular systems when a threat of preterm delivery exists. Postnatally, they are used to prevent and treat respiratory distress syndrome. This study investigates the effects of antenatal (ACT) and early postnatal corticosteroid treatment (PCT) on serum cortisol and plasma catecholamine and adenosine 3',5'-cyclic monophosphate (cAMP) concentrations in preterm neonates. The infants in the ACT group had a significantly lower cortisol concentration than the infants in the non-ACT group on the first day of life. After birth, the infants were further divided into non-PCT and PCT groups. PCT suppressed cortisol levels significantly after 2 days, and the cortisol levels were still lower 2 days after discontinuation of PCT. No effect of PCT on plasma cAMP or catecholamine concentrations was observed. The results indicate that both ACT and a short PCT can significantly suppress basal cortisol levels in preterm infants.
Karlsson
R
R
Department of Pediatrics, University of Turku, Turku, Finland. riikka.karlsson@utu.fi
Kallio
J
J
Toppari
J
J
Scheinin
M
M
Kero
P
P
D002395:Catecholamines / Q000097:blood; D002585:Cesarean Section; D000242:Cyclic AMP / Q000097:blood; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005865:Gestational Age; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D007231:Infant, Newborn; D007234:Infant, Premature; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives* / Q000097:blood; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy / Q000517:prevention & control
D002395:Catecholamines; D005938:Glucocorticoids; D008734:Methoxyhydroxyphenylglycol; D003907:Dexamethasone; D000242:Cyclic AMP; C010117:3,4-dihydroxyphenylglycol; D006854:Hydrocortisone