title: Crossing of antinuclear antibodies and anti-leishmania antibodies.
abstract: Visceral leishmaniasis or Kala-azar is an endemic parasitic infection in Mediterranean countries. We report an interesting case occurring in a 38-year-old woman suffering from systemic lupus erythematosus and secondary antiphospholipid syndrome. In our patient visceral leishmaniasis occurred during high dose-steroids treatment mimicking a flare of lupus. As the lupus resolved under immunosuppressive treatment, a reactivation of visceral leishmaniasis was observed and was confirmed by the successive serological tests which showed crossing of leishmania and antinuclear antibody titers. Our case shows that, faced with fever occurring in lupus patients in an endemic area, visceral leishmaniasis should be searched for before intensifying immunosuppressive treatments.
authors.affiliation: Service de Médecine Interne, CHU Timone, Marseille, France.
authors.forename: B
authors.initials: B
authors.lastname: Granel
authors.forename: J
authors.initials: J
authors.lastname: Serratrice
authors.forename: L
authors.initials: L
authors.lastname: Swiader
authors.forename: F
authors.initials: F
authors.lastname: Gambarelli
authors.forename: L
authors.initials: L
authors.lastname: Daniel
authors.forename: C
authors.initials: C
authors.lastname: Fossat
authors.forename: S
authors.initials: S
authors.lastname: Hesse-Bonérandi
authors.forename: X
authors.initials: X
authors.lastname: Pache
authors.forename: P
authors.initials: P
authors.lastname: Disdier
authors.forename: P J
authors.initials: PJ
authors.lastname: Weiller
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D000913:Antibodies, Protozoan / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D018501:Antirheumatic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D016867:Immunocompromised Host; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000175:diagnosis* / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D000913:Antibodies, Protozoan; D018501:Antirheumatic Agents; D006886:Hydroxychloroquine