title: Use of systemic agents in the treatment of acne vulgaris.
abstract: Effective treatment of acne vulgaris can prevent emotional and physical scarring. Therapy varies according to the severity of the disease. Topical medication is generally adequate in clearing comedonal acne, while inflammatory acne usually requires the addition of oral medication. Systemic antibiotics are used most frequently and can be highly effective. Newer formulations of combined oral contraceptives are also helpful in modulating sebum production in the female patient. Severe nodulocystic acne that does not respond to topical retinoids and systemic antibiotics may be treated with isotretinoin. However, the side effect profile of this medication is extensive, and physicians should be well-versed in its potential adverse effects.
authors.affiliation: Virginia Commonwealth University Medical College of Virginia School of Medicine, Richmond 23298-0230, USA.
authors.forename: B A
authors.initials: BA
authors.lastname: Johnson
authors.forename: J R
authors.initials: JR
authors.lastname: Nunley
mesh_terms: D000152:Acne Vulgaris / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012739:Gonadal Steroid Hormones / Q000627:therapeutic use; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use; D010353:Patient Education as Topic; D013664:Teaching Materials
chemical_list: D000900:Anti-Bacterial Agents; D003879:Dermatologic Agents; D012739:Gonadal Steroid Hormones; D015474:Isotretinoin