[Increased procalcitonin level in bacteriogenic metabolic disturbances. A new possibility for diagnosis and treatment monitoring in sepsis].
Earlier observations of increased plasma concentrations of immunoreactive calcitonin (32 amino acids) in sepsis and other non-tumorous conditions may be explained by increased secretion of procalcitonin, the 116-amino acid prohormone. At present, the site(s) of origin of procalcitonin in sepsis, the factors regulating its biosynthesis and release, the route(s) of its elimination from blood as well as its biological function(s) are unknown. The rapid increase in procalcitonin concentration in sepsis--in some patients earlier than that of C-reactive protein--and decrease upon successful chemotherapy makes procalcitonin a potentially important biomarker in monitoring patients with suspected or confirmed sepsis.
Lindstedt
G
G
Avdelningen för klinisk kemi och transfusionsmedicin, Göteborgs universitet, Sahlgrenska. goran.lindstedt.gu@telia.com
Lundberg
P A
PA
Larsson
B
B
Lindberg
J
J
Mattsby-Baltzer
I
I
Lange
S
S
D015415:Biomarkers / Q000032:analysis*; D002116:Calcitonin / Q000097:blood* / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D003422:Critical Care; D006801:Humans; D008991:Monitoring, Physiologic; D009102:Multiple Organ Failure / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism
D015415:Biomarkers; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide