Effect of the adhesive antibiotic TA on adhesion and initial growth of E. coli on silicone rubber.
Catheter-associated urinary tract infection is the most common nosocomial infection, and contributes to patient morbidity and mortality. We investigated the effect that the TA adhesive antibiotic had on adhesion and initial growth in urine of Escherichia coli on silicone rubber. The TA antibiotic had reduced adhesion, and inhibited initial growth of the bacteria on the surface. Since adhesion and initial growth on the surface are an essential part of biofilm formation and subsequent infection, we speculate that the TA antibiotic coating might decrease the infection rate associated with indwelling urinary catheter.
Simhi
E
E
Schneider Children's Medical Center of Israel, Petah-Tikva, Israel. simhieli@internet-zahav.net
van der Mei
H C
HC
Ron
E Z
EZ
Rosenberg
E
E
Busscher
H J
HJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D004927:Escherichia coli Infections / Q000382:microbiology; D006801:Humans; D018942:Macrolides; D012826:Silicone Elastomers; D014552:Urinary Tract Infections / Q000382:microbiology; D014556:Urine / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D012826:Silicone Elastomers; C035536:Myxococcus xanthus antibiotic TA