Synthesis of phosphonic analogues of 4-hydroxyproline and 5-hydroxypipecolic acid.
Interest in non-natural amino acids is growing because of their potential biological activity. We describe in this paper, a synthesis of phosphonic analogues of 4-hydroxy proline and 5-hydroxy pipecolic acid.
El Khalabi
R
R
Laboratoire de Chimie Organique Faculté des Sciences Dhar El Mehraz Université Sidi Mohamed ben Abdellah, Fès, Maroc.
El Hallaoui
A
A
Ouazzani
F
F
Elachqar
A
A
Atmani
A
A
Roumestant
M L
ML
Viallefont
P
P
Martinez
J
J
D000818:Animals; D003500:Cyclization; D006909:Hydroxyproline / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D010875:Pipecolic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D051381:Rats
D063065:Organophosphonates; D010875:Pipecolic Acids; C053574:5-hydroxypipecolic acid; D006909:Hydroxyproline