CD36 and atherosclerosis.
CD36 has been associated with diverse normal and pathologic processes. These include scavenger receptor functions (uptake of apoptotic cells and modified lipid), lipid metabolism and fatty acid transport, adhesion, angiogenesis, modulation of inflammation, transforming growth factor-beta activation, atherosclerosis, diabetes and cardiomyopathy. Although CD36 was identified more than 25 years ago, it is only with the advent of recent genetic technology that in-vivo evidence has emerged for its physiologic and pathologic relevance. As these in-vivo studies are expanded, we will gain further insight into the mechanism(s) by which CD36 transmits a cellular signal, and this will allow the design of specific therapeutics that impact on a particular function of CD36.
Silverstein
R L
RL
Weill Medical College of Cornell University, Department of Medicine, New York, New York 10021, USA.
Febbraio
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M
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D018955:CD36 Antigens / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002448:Cell Adhesion; D006801:Humans; D007249:Inflammation / Q000209:etiology; D050356:Lipid Metabolism; D008565:Membrane Proteins; D009389:Neovascularization, Pathologic; D011971:Receptors, Immunologic / Q000378:metabolism; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
D018955:CD36 Antigens; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D016212:Transforming Growth Factor beta