title: Evaluating the frequency rate of hypomagnesemia in critically ill pediatric patients by using multiple regression analysis and a computer-based neural network.
abstract: OBJECTIVE
  To determine the frequency rate of hypomagnesemia in patients admitted to the pediatric intensive care unit (ICU), and to identify subsets of patients (grouped by disease) who are at greatest risk of hypomagnesemia. We also compared a neural network model with multiple regression analysis to identify independent variables that would correlate with hypomagnesemia and to predict serum magnesium values in critically ill pediatric patients overall.
  
  
  METHODS
  Prospective, multicenter study.
  
  
  METHODS
  Tertiary level medical/surgical pediatric ICUs.
  
  
  METHODS
  Data were obtained at admission to the pediatric ICU for 463 patients from newborn to 18 yrs old who were admitted with a variety of surgical and nonsurgical conditions.
  
  
  METHODS
  None.
  
  
  RESULTS
  Total serum magnesium values were obtained within the first 24 hrs after admission in 463 pediatric patients admitted to four pediatric ICUs. Hypomagnesemia (defined as total serum magnesium <0.75 mmol/L) was found in 51 (11%) of the 463 patients, with the highest frequency rate (72%) and lowest mean serum magnesium level (0.66 +/- 0.17 mmol/L) in patients admitted after surgery with extensive osseous involvement (spinal fusion and craniofacial reconstruction). To determine whether hypomagnesemia could be predicted on the basis of other laboratory and clinical criteria, multiple regression analysis was performed and showed age, weight, and albumin levels weakly associated (r2 = .14, p < .001) with magnesium levels within the different diagnostic groups. These data were used to produce a mathematical model able to predict magnesium levels within 5% of the actual values in 23% of patients. A neural network was also created to compare its predictive capabilities to those of the multiple regression model. Once trained on a random subset (85%) of the patient population, the neural network was able to predict magnesium levels to within 5% of actual values for 88% of the remaining 15% of patients, comparing favorably with the predictions derived from the multiple regression model.
  
  
  CONCLUSIONS
  Hypomagnesemia is not uncommon (11%) in critically ill pediatric patients, but is very common (72%) in patients admitted after surgery for spinal fusion or craniofacial reconstruction. Patients who undergo surgery for correction of scoliosis and craniofacial anomalies should have serum magnesium levels monitored closely after surgery. In other patients, a neural network or multiple regression model could help predict which patients would be at risk of developing hypomagnesemia, thereby focusing testing on patients likely to benefit from such testing.
authors.affiliation: Pediatric Intensive Care, Hope Children's Hospital and Medical Center, Oak Lawn, IL 60453, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Verive
authors.forename: J
authors.initials: J
authors.lastname: Irazuzta
authors.forename: C M
authors.initials: CM
authors.lastname: Steinhart
authors.forename: J P
authors.initials: JP
authors.lastname: Orlowski
authors.forename: D G
authors.initials: DG
authors.lastname: Jaimovich
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000601:surgery; D016638:Critical Illness; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D008275:Magnesium Deficiency / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D016571:Neural Networks, Computer; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D012600:Scoliosis / Q000601:surgery; D013123:Spinal Fusion / Q000009:adverse effects