Vanadium-contaminated perioperatively administered infusion solutions and drugs.
Vanadium was determined in 51 solutions and drugs for intravenous administration and in 6 salt components of a multitrace element solution using electrothermal atomic absorption spectrometry. The highest V contaminations were found in albumin solutions showing values of more than 600 microg/L V. Two heparines contained 14.3 and 122 microg/L V, respectively. In the ultratrace element solution, 14.8 microg/L vanadium were determined. The most contaminated salt of this solution was Mn(II)-DL-aspartate (12.8 microg V/g). The concentrations of unbound V (Vf) in the albumin solutions were between 0.31 and 299 microg/L. The manufacturing process is the reason for V contamination. The biological half-life of V administered intravenously by albumin solutions in man was about 125 h.
Heinemann
G
G
Institut für Laboratoriumsmedizin, Deutsches Herzzentrum München des Freistaates Bayern, Klinik an der Technischen Universität, Germany.
Vogt
W
W
D000418:Albumins / Q000737:chemistry; D004340:Drug Contamination; D006207:Half-Life; D006493:Heparin / Q000737:chemistry; D007262:Infusions, Intravenous; D007432:Intraoperative Period; D019999:Pharmaceutical Solutions / Q000032:analysis*; D013054:Spectrophotometry, Atomic; D014131:Trace Elements / Q000032:analysis; D014639:Vanadium / Q000032:analysis*
D000418:Albumins; D019999:Pharmaceutical Solutions; D014131:Trace Elements; D014639:Vanadium; D006493:Heparin