Bacterial interplay at intestinal mucosal surfaces: implications for vaccine development.
The discovery of 'molecular syringes' in several important gastrointestinal pathogens including Escherichia coli, Salmonella, Shigella and Yersinia, together with a better understanding of M cells and the mucosal immune system, has advanced our appreciation of multistage microorganism-host cell interactions. Recent studies suggest that these molecular strategies could be adapted for the development of modular mucosal vaccines.
Autenrieth
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IB
Institut für Medizinische Mikrobiologie, Eberhard-Karls Universität Tübingen, 72076, Tübingen, Germany. infekt@uni-muenster.de
Schmidt
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MA
D001426:Bacterial Proteins / Q000378:metabolism; D001428:Bacterial Vaccines; D004755:Enterobacteriaceae / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D004756:Enterobacteriaceae Infections / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology* / Q000382:microbiology*; D014774:Virulence
D001426:Bacterial Proteins; D001428:Bacterial Vaccines