title: Stereotactic brain biopsies in AIDS patients--early local experience.
abstract: OBJECTIVE
  To assess the usefulness of stereotactic brain biopsies in AIDS patients with cerebral lesions in Singapore.
  
  
  METHODS
  A total of 10 patients with AIDS and cerebral lesions underwent stereotactic brain biopsies in the Department of Neurosurgery, Tan Tock Seng Hospital (TTSH) between September 1997 and September 1998. The patients were referred from the Communicable Diseases Centre (CDC), TTSH. These patients either failed a trial of therapy for toxoplasmosis encephalitis (TE) or had CT/MRI scans which did not suggest TE. Four were CT-guided and six were MRI-guided stereotactic biopsies. The Radionics Cosman-Robert-Wells (CRW) stereotactic apparatus was used for all cases.
  
  
  RESULTS
  The male to female ratio was 9:1. Histological diagnosis from biopsy was lymphoma (5), metastatic adenocarcinoma (1), TE (1), abscess (1), encephalitis (1) and granulomatous tissue (1-presumed tuberculosis).
  
  
  CONCLUSIONS
  The early experience is that stereotactic brain biopsy is useful in patients with AIDS and cerebral lesions. The etiology is confirmed in the majority of cases and impacts on management decisions and prognostication.
authors.affiliation: Department of Neurosurgery, National Neuroscience Institute, Tan Tock Seng, Singapore.
authors.forename: K K
authors.initials: KK
authors.lastname: Yeo
authors.forename: T T
authors.initials: TT
authors.lastname: Yeo
authors.forename: C Y
authors.initials: CY
authors.lastname: Chan
authors.forename: Y Y
authors.initials: YY
authors.lastname: Sitoh
authors.forename: J
authors.initials: J
authors.lastname: Teo
authors.forename: S Y
authors.initials: SY
authors.lastname: Wong
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D001706:Biopsy / Q000379:methods*; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013238:Stereotaxic Techniques