title: Energy-dependent UV light-induced disruption of (-)sulpiride antagonism of dopamine.
abstract: The dopamine D2 receptor antagonist sulpiride decreases the spontaneous locomotor activity of Planaria in an enantiomeric-selective and dose-dependent manner. We now report that (-)sulpiride (0.1 microM)-induced decrease of planarian locomotor activity is significantly (P<0.05) attenuated by low-energy (366 nm) ultraviolet (UV) light and to a greater extent by high-energy (254 nm) UV light. The phenomenon offers a novel approach for studying dopamine D2 receptor transduction processes in a simple in vivo model.
authors.affiliation: Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA. rraffa@nimbus.temple.edu
authors.forename: R B
authors.initials: RB
authors.lastname: Raffa
authors.forename: J M
authors.initials: JM
authors.lastname: Valdez
authors.forename: L J
authors.initials: LJ
authors.lastname: Holland
authors.forename: R J
authors.initials: RJ
authors.lastname: Schulingkamp
mesh_terms: D000818:Animals; D018492:Dopamine Antagonists / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D010932:Planarians; D017448:Receptors, Dopamine D2 / Q000378:metabolism / Q000528:radiation effects*; D013469:Sulpiride / Q000378:metabolism / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D013469:Sulpiride