Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ).
Macdonald
D
D
Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Québec, Canada, H9R 4P8. dwight_macdonald@merk.com
Perrier
H
H
Liu
S
S
Laliberté
F
F
Rasori
R
R
Robichaud
A
A
Masson
P
P
Huang
Z
Z
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016084:Bronchoconstriction / Q000187:drug effects; D002460:Cell Line; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005289:Ferrets; D006168:Guinea Pigs; D006801:Humans; D019920:Photoaffinity Labels / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014839:Vomiting / Q000139:chemically induced*
C415562:8-(3-azidophenyl)-6-((4-iodo-1H-1-imidazolyl)methyl)quinoline; D018927:Anti-Asthmatic Agents; D001386:Azides; D004791:Enzyme Inhibitors; D019920:Photoaffinity Labels; D011804:Quinolines; D011993:Recombinant Fusion Proteins; D014409:Tumor Necrosis Factor-alpha; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4