Estimation of cord blood erythropoietin in pre-eclampsia and eclampsia.
OBJECTIVE
The estimation of cord blood erythropoietin in subjects with pre-eclampsia and eclampsia.


METHODS
Erythropoietin was measured, using ELISA, in the cord blood of infants born to 83 mothers with pre-eclampsia, and 7 with eclampsia. Another 90 subjects with no evidence of pre-eclampsia or eclampsia were taken as control subjects. Maternal parity, gestational age, blood pressures, 24-h urine protein and Apgar scores of the infants delivered were also noted.


RESULTS
Cord blood erythropoietin levels were statistically significantly higher (P<0.001) in infants born to mothers with pre-eclampsia and eclampsia. There was a significant positive correlation (P<0.01) between cord blood erythropoietin levels and maternal blood pressure (systolic and diastolic) and albuminuria. A negative correlation (P<0.01) was observed with the birth weights of infants.


CONCLUSIONS
Pre-eclampsia and eclampsia are associated with higher levels of cord blood erythropoietin.
Gupta
G
G
Department of Obstetrics and Gynecology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Gupta
I
I
Suri
V
V
Dhawan
V
V
Ganguly
N K
NK
D000328:Adult; D000419:Albuminuria / Q000652:urine; D001034:Apgar Score; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D001794:Blood Pressure; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D020073:Gravidity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000652:urine; D014527:Uric Acid / Q000097:blood
D015415:Biomarkers; D004921:Erythropoietin; D014527:Uric Acid