Improved dysgammaglobulinaemia in congenital rubella syndrome after immunoglobulin therapy: correlation with CD154 expression.
A boy with congenital rubella syndrome developed dysgammaglobulinaemia with elevated serum levels of IgM. CD154 was not induced on his peripheral blood mononuclear cells when rubella virus RNA was detected in his throat swabs and peripheral blood by reverse transcriptase polymerase chain reaction. Following intravenous immunoglobulin therapy, improvement of immunoglobulin abnormalities, disappearance of rubella virus and normalisation of CD154 expression were demonstrated.


CONCLUSIONS
These findings implicate the efficacy of intravenous immunoglobulin therapy for dysgammaglobulinaemia in congenital rubella syndrome and a role of CD154 for a prolonged virus infection.
Kawamura
N
N
Department of Paediatrics, Hokkaido University School of Medicine, Sapporo, Japan. nobu-ka@med.hokudai.ac.jp
Okamura
A
A
Furuta
H
H
Katow
S
S
Yamada
M
M
Kobayashi
I
I
Okano
M
M
Kobayashi
K
K
Sakiyama
Y
Y
D000914:Antibodies, Viral / Q000097:blood*; D023201:CD40 Ligand / Q000276:immunology*; D004406:Dysgammaglobulinemia / Q000209:etiology / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012410:Rubella Syndrome, Congenital / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D012412:Rubella virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D016896:Treatment Outcome
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D012367:RNA, Viral; D023201:CD40 Ligand