Amantadine monotherapy of chronic hepatitis C patients infected with genotype lb.
We aimed to test the efficacy of amantadine in chronic hepatitis C (CHC) patients infected with genotype b. Twenty patients completed treatment with amantadine HCl, 100 mg b.i.d., for 6 months. Non-sustained biochemical improvement was observed without loss of HCV-RNA. We conclude that amantadine monotherapy is not effective in CHC.
Senturk
H
H
Department of Internal Medicine, Cerrahpasa Medical Faculty of Istanbul University, Turkey.
Mert
A
A
Akdogan
M
M
Tabak
F
F
Basaran
G
G
Turkoglu
S
S
Ozbay
G
G
Badur
S
S
D000293:Adolescent; D000328:Adult; D000547:Amantadine / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D017211:Treatment Failure
D000998:Antiviral Agents; D012367:RNA, Viral; D000547:Amantadine