title: Crystallization and preliminary X-ray analysis of CTLA-4 (CD152) membrane-external domain.
abstract: CTLA-4 (CD152) is involved in T-lymphocyte co-stimulatory pathways modulating both humoral and cellular immune response. The membrane-external domain has been prepared and crystallized. The unit-cell parameters are a = b = 43, c = 143 A with the symmetry of space group P3(1)21 or its enantiomer and the crystals diffract to 2. 7 A resolution at synchrotron beamlines.
authors.affiliation: Macromolecular Structure, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chang
authors.forename: W H
authors.initials: WH
authors.lastname: Fenderson
authors.forename: T B
authors.initials: TB
authors.lastname: Lavoie
authors.forename: R J
authors.initials: RJ
authors.lastname: Peach
authors.forename: H M
authors.initials: HM
authors.lastname: Einspahr
authors.forename: S
authors.initials: S
authors.lastname: Sheriff
mesh_terms: D000069594:Abatacept; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000737:chemistry*; D060908:CTLA-4 Antigen; D003460:Crystallization; D018360:Crystallography, X-Ray; D018796:Immunoconjugates; D008565:Membrane Proteins / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; D018796:Immunoconjugates; D008565:Membrane Proteins; D000069594:Abatacept