Discovery of potent cyclic pseudopeptide human tachykinin NK-2 receptor antagonists.
Giannotti
D
D
Menarini Ricerche S.p.A., Via Sette Santi 3, I-50131 Firenze, Italy. fbenincasa@menarini-richerche.it
Perrotta
E
E
Di Bugno
C
C
Nannicini
R
R
Harmat
N J
NJ
Giolitti
A
A
Patacchini
R
R
Renzetti
A R
AR
Rotondaro
L
L
Giuliani
S
S
Altamura
M
M
Maggi
C A
CA
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D066298:In Vitro Techniques; D008958:Models, Molecular; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D017354:Point Mutation; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D011869:Radioligand Assay; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
C107754:MEN 11420; D010456:Peptides, Cyclic; D018041:Receptors, Neurokinin-2; C090951:MEN 10627