title: Burst excitation for quantitative diffusion imaging with multiple b-values.
abstract: A quantitative imaging sequence has been developed to exploit the intrinsic sensitivity of Burst NMR data to molecular diffusion. In the scan time of a single spin echo experiment, it is possible to acquire many images of the same slice, with a different T(2) and diffusion weighting. Under favorable conditions, it is possible to obtain both the diffusion coefficient and T(2) from the same experiment; or, by correcting for T(2) relaxation using a control image, more precise diffusion coefficients may be measured. The quantitative values in rat brain are in agreement with those from conventional experiments. The major gains of this method are the potentially reduced scan time, the higher number of acquired images corresponding to different diffusion weightings, the reduced sensitivity to inter-scan motion artifact and to local variations in magnetic susceptibility, and an automatic co-registration between T(2) and diffusion images. Problems with the sequence include a lower signal-to-noise ratio than is achievable with diffusion-weighted spin-echo imaging, the limitation of measuring only in-plane components of diffusion and, at present, single-slice acquisition.
authors.affiliation: NMR Unit, Department of Clinical Neurology, Institute of Neurology, UCL, London, UK. c.wheeler-kingshott@ion.ucl.ac.uk
authors.forename: C A
authors.initials: CA
authors.lastname: Wheeler-Kingshott
authors.forename: D L
authors.initials: DL
authors.lastname: Thomas
authors.forename: M F
authors.initials: MF
authors.lastname: Lythgoe
authors.forename: D
authors.initials: D
authors.lastname: Guilfoyle
authors.forename: S R
authors.initials: SR
authors.lastname: Williams
authors.forename: S J
authors.initials: SJ
authors.lastname: Doran
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D004058:Diffusion; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051381:Rats; D017208:Rats, Wistar