Antiandrogenic effect of new synthetic steroids.
These results indicate that castration decreased the flank organ diameter and the weight of the seminal vesicles, whereas daily injection of testosterone restores them. However injections of finasteride together with testosterone inhibited the diameter of the flank organs, the weight of the seminal vesicles, and the conversion of testosterone to dihydrotestosterone. The four compounds tested inhibited flank organ diameter size and the weight of the seminal vesicles as compared to the testosterone-treated animals. On the other hand, none of these compounds suppressed the conversion of testosterone to dihydrotestosterone. These results suggest that the synthesized steroids compete with androgen receptors.
Cabeza
M
M
Department of Biological Systems, Agricultural and Animal Production Metropolitan University-Xochimilco, Mexico, D.F.
Quiroz
A
A
Heuze
I
I
Bratoeff
E
E
Herrera
H
H
Ramírez
E
E
Murillo
E
E
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D013196:Dihydrotestosterone / Q000378:metabolism; D018120:Finasteride / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009919:Orchiectomy; D012669:Seminal Vesicles / Q000187:drug effects / Q000378:metabolism; D013256:Steroids / Q000494:pharmacology*; D013739:Testosterone / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology
D000726:Androgen Antagonists; D013256:Steroids; D013196:Dihydrotestosterone; D013739:Testosterone; D018120:Finasteride