[Risk of increased malignancy a reason for follow-up of low malignancy grade glioma. Early identification of high-risk patients is the key to good care].
Management of patients with low-grade gliomas remains a challenge. Controversies exist regarding the value of surgery and radiotherapy as well as the right timing of these treatments with respect to disease course. Several factors have been shown to have a positive correlation with better outcome, involving tumor size and localization, age and clinical condition of the patient on presentation, and epileptic seizures as a single symptom. The absence of contrast enhancement on CT-scans is also a favorable prognostic factor. Taking into account the results of these studies as well as our own experience, we suggest some strategies for the management of patients with low-grade gliomas. The importance of identifying "high-risk" patients by systematic clinical and radiological follow-up is discussed.
Smits
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Akademiska sjukhuset, Uppsala. Anja.Smits@neurologi.uu.se
Ribom
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D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D017410:Practice Guidelines as Topic; D011379:Prognosis; D012307:Risk Factors; D013548:Sweden; D014055:Tomography, Emission-Computed