title: Body temperature as a risk factor for Alzheimer's disease.
abstract: A number of risk factors underlie the development of Alzheimer's disease. We propose low body temperature is also implicated. This is based on the belief that low temperature influences the biomechanics of the disease and promotes its development. Support for this hypothesis is found in a consideration of temperature effects on the disease process, in anecdotal observations and from our studies of people with Down syndrome.
authors.affiliation: Elwyn Inc., Elwyn, Pennsylvania, USA. holtzm@wserv.com
authors.forename: A
authors.initials: A
authors.lastname: Holtzman
authors.forename: E W
authors.initials: EW
authors.lastname: Simon
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001831:Body Temperature; D004314:Down Syndrome / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D016229:Amyloid beta-Peptides