title: Beneficial microbes: health or hazard?
abstract: Normal microbial flora support the health of the host by diverse mechanisms. When antibiotics, stress, disease or medications disrupt normal microflora, the ability to ward off infection by pathogens is compromised. The use of beneficial microbes (also known as biotherapeutic agents, probiotics, synbiotics) has been shown to be an effective therapeutic agent for some diseases. Various types of diarrhoea (antibiotic-associated diarrhoea, Clostridium difficile disease, traveller's diarrhoea) are most responsive to these beneficial microbes. Serious risks associated with these microbes are largely theoretical at this point, but the risks need to be studied as the use of these beneficial microbes increases in popularity. Beneficial microbes are living organisms used as therapeutic agents to restore the health of the host in times when normal microflora have been disturbed. The efficacy to prevent or treat diarrhoea has been documented in multiple large, placebo-controlled, blinded clinical trials with only a few of these beneficial microbes. Risks of these beneficial microbes are limited, but potential risks have not been extensively studied in large numbers of patients.
authors.affiliation: Department of Medicinal Chemistry, University of Washington, Seattle, USA. lvmcfarl@u.washington.edu
authors.forename: L V
authors.initials: LV
authors.lastname: McFarland
mesh_terms: D003967:Diarrhea / Q000628:therapy*; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology / Q000628:therapy; D006801:Humans; D007778:Lactobacillus; D019936:Probiotics / Q000009:adverse effects / Q000627:therapeutic use*; D012307:Risk Factors; D012440:Saccharomyces