title: No association between breast-feeding and adult psychosis in two national birth cohorts.
abstract: BACKGROUND
  It has been proposed that breast-feeding might have a protective effect against the development of adult schizophrenia.
  
  
  OBJECTIVE
  To test this hypothesis.
  
  
  METHODS
  Using prospective data from two UK national birth cohorts, the feeding histories of those who later developed schizophrenia were compared with the remaining population at risk. Analyses in each cohort were considered to be independent tests of the hypothesis.
  
  
  RESULTS
  There were no differences in feeding histories. In the 1946 birth cohort (n = 4447) 30 cases of DSM-III-R schizophrenia arose by age 43; 24.1% of cases v. 23.6% of controls were entirely bottle-fed; 17.3% v. 12.3% were breast-fed for under 1 month; 58.6% v. 64.1% were breast-fed beyond 1 month. In the 1958 cohort (n = 18,856), 40 cases of CATEGO nuclear schizophrenia arose by age 28; 24.1% of cases v. 31.7% of controls were entirely bottle-fed; 27.6% v. 24.9% were breast-fed for under 1 month; 48.3% v. 43.4% were breast-fed beyond 1 month.
  
  
  CONCLUSIONS
  These findings provide no evidence of any effect of breast-feeding in protecting against the risk of later schizophrenia.
authors.affiliation: University of Nottingham Department of Psychiatry.
authors.forename: S J
authors.initials: SJ
authors.lastname: Leask
authors.forename: D J
authors.initials: DJ
authors.lastname: Done
authors.forename: T J
authors.initials: TJ
authors.lastname: Crow
authors.forename: M
authors.initials: M
authors.lastname: Richards
authors.forename: P B
authors.initials: PB
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D001942:Breast Feeding / Q000523:psychology*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D011618:Psychotic Disorders / Q000517:prevention & control*; D012559:Schizophrenia / Q000517:prevention & control*; D017678:Sex Distribution; D012923:Social Class