title: Large-scale cellular automata simulations of the immune system response.
abstract: The sequential nature of the process allowing the immune system to learn how to withstand pathogen agents is explored by means of large-scale computer simulation of the Celada-Seiden immunological automaton. In accord with our previous results, it is found that the learning process proceeds via a sequential cascade in affinity space.
authors.affiliation: Istituto Applicazioni Calcolo, CNR, Viale Policlinico 137, 00161, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bernaschi
authors.forename: S
authors.initials: S
authors.lastname: Succi
authors.forename: F
authors.initials: F
authors.lastname: Castiglione
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D003198:Computer Simulation; D003201:Computers; D007107:Immune System / Q000166:cytology* / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology*; D018448:Models, Immunological