Novel therapy for COPD.
The incidence of chronic obstructive pulmonary disease (COPD) is increasing throughout the world. Much less is known about the pathogenesis of COPD than that of asthma and there is little response to current therapy. Most patients with COPD have acquired their lung disease through smoking cigarettes, and the major step in management is to minimise further damage by stopping this habit. A number of therapies are being developed for the treatment of COPD; including new bronchodilators such as tiotropium bromide, agents to block inflammation induced by neutrophils and macrophages, as well as strategies to combat proteases and oxidants. The long-term goal is to provide therapy that retards the accelerated loss of lung function occurring in COPD. Development of novel therapies for COPD requires reliable Phase II decision making before entering large scale Phase III studies. The patient with COPD is often overlooked compared to their asthmatic counterpart, who benefit from an urgent need to identify novel targets and better therapy.
Leckie
M J
MJ
National Heart and Lung Institute, Royal Brompton Clinical Studies Unit, Imperial College, London, UK.
Bryan
S A
SA
Hansel
T T
TT
Barnes
P J
PJ
D000318:Adrenergic beta-Agonists; D000818:Animals; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001993:Bronchodilator Agents; D018925:Chemokines / Q000037:antagonists & inhibitors; D018680:Cholinergic Antagonists; D016207:Cytokines / Q000037:antagonists & inhibitors; D015507:Drugs, Investigational; D004791:Enzyme Inhibitors; D005100:Expectorants; D005938:Glucocorticoids; D006801:Humans; D020024:Leukotriene Antagonists; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D010102:Oxygen Inhalation Therapy; D018039:Receptors, Tachykinin; D019141:Respiratory System Agents / Q000494:pharmacology / Q000627:therapeutic use; D016540:Smoking Cessation; D013806:Theophylline
D000318:Adrenergic beta-Agonists; D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001993:Bronchodilator Agents; D018925:Chemokines; D018680:Cholinergic Antagonists; D016207:Cytokines; D015507:Drugs, Investigational; D004791:Enzyme Inhibitors; D005100:Expectorants; D005938:Glucocorticoids; D020024:Leukotriene Antagonists; D018039:Receptors, Tachykinin; D019141:Respiratory System Agents; D013806:Theophylline