title: Serological HLA class I alleles in Senegalese blood donors detected HBs Ag positive.
abstract: We analysed the HLA class I alleles in 96 blood donors HBs Ag positive compared with 93 healthy control individuals (HBs negative). The most frequent HLA-A, -B, -C alleles found were, A23 (33.6%); A2 (25%); A30 (25%); B8 (31.5%); B7 (16.3%); B58 (11.9%); B35 (11.9%); B49 (11.9%); B53 (10.8%); Cw7 (39.1%); Cw3 (36.9%); Cw4 (36.9%). Significant differences (P<0.001) were found between the blood donors and the controls for the following HLA alleles, A1; A23; B8 and Cw3. The detection of HBe antigen was positive in 26/84 blood donors. It was observed a significant difference (P<0.01; odds ratios (OR)=6.25) between positive and negative HBe antigens blood donors for HLA-A1 allele.
authors.affiliation: Immunogénétique moléculaire, Institut Pasteur de Dakar, B.P. 220, Dakar, Senegal.
authors.forename: V
authors.initials: V
authors.lastname: Obami-Itou
authors.forename: M F
authors.initials: MF
authors.lastname: Barry
authors.forename: G
authors.initials: G
authors.lastname: Raphenon
authors.forename: A
authors.initials: A
authors.lastname: Thiam
authors.forename: R
authors.initials: R
authors.lastname: Ndiaye
authors.forename: M
authors.initials: M
authors.lastname: Ndiaye
authors.forename: M L
authors.initials: ML
authors.lastname: Diaw
authors.forename: L
authors.initials: L
authors.lastname: Diakhate
authors.forename: A
authors.initials: A
authors.lastname: Dieye
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002353:Carrier State / Q000453:epidemiology*; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015788:HLA-A1 Antigen / Q000032:analysis / Q000235:genetics; D015795:HLA-B8 Antigen / Q000032:analysis / Q000235:genetics; D006509:Hepatitis B / Q000453:epidemiology* / Q000235:genetics; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006513:Hepatitis B e Antigens / Q000097:blood*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D012675:Senegal / Q000453:epidemiology; D016036:Seroepidemiologic Studies
chemical_list: D015788:HLA-A1 Antigen; D015795:HLA-B8 Antigen; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens