Can kinetic analysis be a tool for evaluating pore characteristics?
As the pore morphology influences drug release, the purpose is to study pore characteristics by comparing bead performances. Casein/gelatin beads have been prepared by the emulsification extraction method, cross-linked with D,L-glyceraldehyde in acetone:water mixture 3:1 (v/v) and loaded with sodium fluorescein as a model drug. The beads with higher casein percentage have a higher matrix porosity, a wider average pore diameter and a higher cross-linking degree. The higher casein percentage causes a lower drug release rate. The kinetic analysis shows that the drug release occurs by diffusion and that the diffusion coefficient is affected by the casein percentage and the cross-linking degree. It can be hypothesized that the pore and channel morphology (tortuosity), due to the casein percentage in the matrix and the cross-linking treatment, can be evaluated by kinetic analysis of the release data.
Bulgarelli
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Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy. forni.flavio@unimo.it
Forni
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Bernabei
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D000284:Administration, Oral; D002214:Capsules; D002364:Caseins; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D019793:Fluorescein / Q000008:administration & dosage / Q000493:pharmacokinetics; D005780:Gelatin; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D013499:Surface Properties
D002214:Capsules; D002364:Caseins; D003692:Delayed-Action Preparations; D005780:Gelatin; D019793:Fluorescein