Gene aberrations in childhood brain tumors.
We present the results of the examination of prognostic markers in 40 children suffering from brain tumors. Prognostic markers such as amplification of the N-myc and c-myc, deletion of the 17p, and DNA ploidy are indispensable factors for the determination of diagnosis. An increased number of c-myc gene copies was found in malignant brain tumors, especially embryonal, more often than reported in the literature. N-myc amplification occurs in our group seldom, but it seems to be a sign of worse prognosis in glial and embryonal brain tumors. DNA aneuploidy was not found very frequently, but in high-grade tumors only.
Kucerová
H
H
Department of Pediatric Oncology, University Hospital Motol, Prague, Czech Republic.
Stejskalová
E
E
Vícha
A
A
Tichý
M
M
Chánová
M
M
Sumerauer
D
D
Koutechký
J
J
Eckschlager
T
T
D000293:Adolescent; D000782:Aneuploidy; D001932:Brain Neoplasms / Q000145:classification / Q000235:genetics*; D002528:Cerebellar Neoplasms / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D005260:Female; D005784:Gene Amplification; D020440:Gene Duplication; D016259:Genes, myc; D005910:Glioma / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000235:genetics; D018242:Neuroectodermal Tumors, Primitive / Q000235:genetics; D011003:Ploidies