Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue.
Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA expression was confirmed in all samples obtained from patients with RA, but not in normal synovium. A-SAA mRNA expression was also demonstrated in cultured RA synoviocytes. A-SAA protein was identified in the supernatants of primary synoviocyte cultures, and its expression colocalized with sites of macrophage accumulation and with some vascular endothelial cells. It is concluded that A-SAA is produced by inflamed RA synovial tissue. The known association between the acute-phase response and progressive joint damage may be the direct result of synovial A-SAA-induced effects on cartilage degradation.
O'Hara
R
R
St Vincent's University Hospital, Dublin, Ireland.
Murphy
E P
EP
Whitehead
A S
AS
FitzGerald
O
O
Bresnihan
B
B
D000208:Acute Disease; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000276:immunology* / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D013583:Synovial Membrane / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology
D015415:Biomarkers; D012333:RNA, Messenger; D000685:Serum Amyloid A Protein