Primary cells suppress oncogene-dependent apoptosis.
Oncogenes that promote cell-cycle progression also sensitize cells to agents that induce apoptosis, possibly by inactivating inhibitors that ordinarily provide protection against cell death. Here we show that the adenoviral oncogene E1A sensitizes cells to an anti-cancer drug by at least two pathways. One establishes a link between the drug and pro-apoptotic factors, but is not sufficient for sensitization without the second pathway, which suppresses inhibitors of apoptosis.
Duelli
D M
DM
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Lazebnik
Y A
YA
D017500:Adenovirus E1A Proteins / Q000378:metabolism*; D017209:Apoptosis; D002478:Cells, Cultured; D003574:Cytochrome c Group / Q000378:metabolism; D005047:Etoposide / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D051028:bcl-2-Associated X Protein
D017500:Adenovirus E1A Proteins; D003574:Cytochrome c Group; D019384:Nucleic Acid Synthesis Inhibitors; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; D051028:bcl-2-Associated X Protein; D005047:Etoposide