[Studies on the production of 16 beta-methyl-11 alpha,17 alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione from 16 beta-methyl-17 alpha,21-dihydroxy-1,4-pregnadiene-3,20-dione-21-acetate by Absidia].
An Absidia sp. 28 strain was shown to have higher activity of 11 alpha-hydroxylation using 16 beta-methyl-17 alpha,21-dihydroxy-1,4-pregnadiene-3,20-dione as a substrate. It was found that 21-acetylization of substrate could increase 11 alpha-hydroxylation rate conspicuously. The yield of the 11 alpha-hydroxylation by this strain was 73% in the conversion of 0.5% concentration of 21-acetated substrate under optimum conditions.
Xu
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SW
Institute of Microbiology, Chinese Academy of Sciences, Beijing.
Xu
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YH
D020095:Absidia / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D006900:Hydroxylation; D011244:Pregnadienediols / Q000378:metabolism*; D011246:Pregnadienetriols / Q000378:metabolism*
D011244:Pregnadienediols; D011246:Pregnadienetriols; D000431:Ethanol