[Effects of total flavones of fructus Hippophae (TFH) on cardiac function and hemodynamics of anesthetized open-chest dogs with acute heart failure].
This study was carried out employing the model of dog with acute heart failure induced by phenobarbital natricum. It was shown that i.v. TFH 4.8 and 9.7 mg/kg could significantly increase CO, CI, + LVdP/dtmax and LVSP; shorten R-dP/dtmax in 9.7 mg/kg; raise - LVdP/dtmax, reduce LVEDP and T value; decrease MVO2I and TPVR; MAP and HR were not changed significantly. The results suggest that i.v. TFH can strengthen cardiac pump function and myocardial contractility in canine with heart failure; significantly improve myocardial diastolic function and hemodynamic performance; markedly decrease myocardia-used oxygen index and total peripheral vessel resistance, thus proving that TFH is good for heart failure.
Wu
Y
Y
Department of Pharmacology, College of Pharmacy, Xian Medical University.
Wang
Y
Y
Wang
B
B
Lei
H
H
Yang
Y
Y
D000818:Animals; D002303:Cardiac Output, Low / Q000139:chemically induced / Q000503:physiopathology*; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010634:Phenobarbital; D010946:Plants, Medicinal / Q000737:chemistry*; D014655:Vascular Resistance / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D010634:Phenobarbital