title: Ultrastructural study of Langerhans cells in equine insect hypersensitivity "Kasen".
abstract: Ultrastructural features of Langerhans cells (LCs) of equine "Kasen" were studied. Electron microscopic observation revealed that LCs were dendritic and had irregular nuclear membranes. A number of Birbeck granules (Bgs) of various types were observed in the cytoplasm of LCs. In LCs in the upper stratum spinous, many Bgs were observed (Type 2 LC). LCs in the epidermo-dermal junction (EDJ) had a few Bgs, vesicles (multivesicular bodies) and highly electron-dense granular endosomes in the cytoplasm (Type 3 LC). Inactive LCs were also observed between the keratinocytes (Type 1 LC). Various types of LCs observed in the skin lesions of equine "Kasen" were interpreted as representing those that recognize, intake and process antigens.
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kurotaki
authors.forename: K
authors.initials: K
authors.lastname: Narayama
authors.forename: T
authors.initials: T
authors.lastname: Oyamada
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000473:pathology / Q000662:veterinary*; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007801:Langerhans Cells / Q000648:ultrastructure*