Histocompatibility antigen (HLA) associations with multiple sclerosis in Iran.
Human leukocyte antigen (HLA) types were obtained from 79 Iranian patients with multiple sclerosis and compared with 100 controls. The prevalence of HLA-A24 (30.3% versus 18.0%), HLA-DR2 (43.0% versus 28. 0%) and HLA-DR15 (36.7% versus 23.0%) were significantly increased in multiple sclerosis patients compared with controls. However age at onset, and disease status (relapsing - remitting or primary progressive) did not show an association with any particular HLA type. Multiple Sclerosis (2000) 6 317 - 319
Kalanie
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H
Department of Neurology, Shohada Hospital, Tajrish, Tehran, Iran.
Kamgooyan
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Sadeghian
H
H
Kalanie
A R
AR
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D015234:HLA-A Antigens / Q000032:analysis* / Q000276:immunology*; D059871:HLA-A24 Antigen; D006684:HLA-DR Antigens / Q000032:analysis* / Q000276:immunology*; D059810:HLA-DR Serological Subtypes; D015802:HLA-DR2 Antigen / Q000032:analysis / Q000276:immunology; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*
D015234:HLA-A Antigens; D059871:HLA-A24 Antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen; D015802:HLA-DR2 Antigen