cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1-q22.3 region.
Members of the RAB protein family regulate vesicular trafficking and reside in specific intercellular compartments. A new member of the RAB family was identified through a public database search, and its full-length cDNA was isolated from a human fetal brain cDNA library. The predicted protein product of the gene consists of 201 amino acid residues, and the protein has 86% similarity to human RAB9 at the amino acid level. We designated the new gene RAB9-like. Northern blot analysis showed that the gene was transcribed ubiquitously in various human tissues. A database search revealed that the gene is divided into three exons and spans approximately 7.2kb of the genome DNA of chromosome Xq22.1-q22.3 region.
Seki
N
N
Helix Research Institute, Kisarazu, Chiba, Japan. nseki@hri.co.jp
Azuma
T
T
Yoshikawa
T
T
Masuho
Y
Y
Muramatsu
M
M
Saito
T
T
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014960:X Chromosome; D020691:rab GTP-Binding Proteins / Q000235:genetics*
D018076:DNA, Complementary; C079856:RAB9A protein, human; C489803:RAB9B protein, human; D020691:rab GTP-Binding Proteins