title: Familial ovarian malignancy.
abstract: Familial ovarian cancer is a subset of ovarian cancer where there appears to be a definable genetic link in families. It accounts for less than 5% of cases of ovarian cancer seen at present. The main genes responsible, BRCA1 and BRCA2, are discussed. Screening and the prophylactic measures for women identified having a genetic trait are discussed.
authors.affiliation: Addenbrooke's Hospital, Cambridge.
authors.forename: R
authors.initials: R
authors.lastname: Crawford
authors.forename: S
authors.initials: S
authors.lastname: Everest
authors.forename: J
authors.initials: J
authors.lastname: Mackay
mesh_terms: D000328:Adult; D000368:Aged; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein; D003276:Contraceptives, Oral / Q000627:therapeutic use; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000517:prevention & control; D010052:Ovariectomy; D015995:Prevalence; D012306:Risk; D014157:Transcription Factors / Q000235:genetics
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein; D003276:Contraceptives, Oral; D009363:Neoplasm Proteins; D014157:Transcription Factors