[Activation of CD4 T lymphocyte and release of interleukin-5 in airway from patients with atopic asthmatics].
OBJECTIVE
To evaluate the action of CD4T cell and release of interleukin-5 in airway from patients with atopic asthma by the allergen-specific stimulation.


METHODS
Twelve atopic asthmatics (AA), 9 atopic non-asthmatics (AN), and 10 normal controls(N) underwent whole-lung inhalation challenge with house dust mite allergen (HDM) extract. The Levels of CD4CD25T lymphocytes, eosinophils(EOS), interleukin-5 (IL-5) and eosinophil cationic protein (ECP) in bronchoalveolar lavage (BAL) and peripheral blood mononuclear cells (PBMC) were investigated with and without HDM challenge.


RESULTS
AA differed from AN in having late airway reactions (LAR) after HDM inhalation (P < 0.01), which was correlated with an percentage of BAL eosinophils, CD4CD25T cell IL-5 production and ECP release.


CONCLUSIONS
These findings suggest that the activation of CD4T lymphocytes is correlated with both asthmatic and atopic status. The allergen-specific stimulation is believed to play a major role in CD4 T cell activation in atopic asthma. IL-5 is selective cytokine for EOS activation and modulating local eosinophil recruitment and activation in airway.
Quan
B
B
Department of Respiratory, 202nd Hospital, PLA, Shenyang.
Tang
C
C
Wang
D
D
D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000378:metabolism; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004804:Eosinophils / Q000378:metabolism; D005260:Female; D006801:Humans; D015848:Interleukin-5 / Q000378:metabolism*; D008213:Lymphocyte Activation; D008297:Male
D015848:Interleukin-5