[Indicators of oxidative stress in cardiovascular diseases. I. Lipoperoxidation].
The level od malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS) respectively, in blood is changing very quickly and therefore isoprostanes scam to be better markers of atherogenesis. Oxidized LDL belong to the most important reasons of the origin of foam cells and therefore of atherogenesis. That is why the inhibition of the oxidation of LDL particles should belong to the standard therapy of cardiovascular diseases. The value of antibodies against oxidized LDL is difficult to interpret, because they are multifactor dependent, especially under genetic control. Antibodies against LDL modified by malondialdehyde (MDA-LDL) are increased in smokers and individuals with a rapid atherosclerotic progression. HDL-cholesterol protects LDL through the oxidized lipid exchange. Oxidized HDL formed during this process has then an increased clearance from circulation.
Racek
J
J
Ustav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzen.
Holecek
V
V
Trefil
L
L
D002318:Cardiovascular Diseases / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress
D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein