[Combined use of zolpidem and enalapril in elderly patients with essential arterial hypertension and sleep problems].
Changes in 24-h profiles of arterial pressure following treatment with zolpidem were studied in 12 patients with essential arterial hypertension and chronic sleep problems on enalapril. One week treatment with zolpidem improved quality of sleep, increased a circadian index of systolic arterial pressure, 3 non-dipper patients recovered circadian rhythm of arterial pressure. The antihypertensive effect at night was higher when enalapril was used in combination with zolpidem than in monotherapy with enalapril.
Ol'binskaia
L I
LI
Khapaev
B A
BA
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011725:Pyridines / Q000627:therapeutic use*; D012893:Sleep Wake Disorders / Q000150:complications* / Q000188:drug therapy*; D000077334:Zolpidem
D000806:Angiotensin-Converting Enzyme Inhibitors; D006993:Hypnotics and Sedatives; D011725:Pyridines; D004656:Enalapril; D000077334:Zolpidem