title: Induction of lepromin positivity and immunoprophylaxis in household contacts of multibacillary leprosy patients: a pilot study with a candidate vaccine, Mycobacterium w.
abstract: We screened 487 household contacts of multibacillary (MB) patients for evidence of disease and their lepromin status. From the 444 results available, 302 (68.02%) were lepromin positive and 142 (31.98%) were lepromin negative on initial testing. The initial lepromin status as assessed in the group of 54 contacts having disease at the outset showed 24 out of 46 (52.2%) to be lepromin positive and 22 of 46 (47.8%) to be lepromin negative. In the same group, among 24 lepromin positives, 22 (91.7%) had paucibacillary (PB) and 2 (8.3%) had multibacillary (MB) disease; among the lepromin negatives, 12 (54.5%) had PB and 10 (45.5%) had MB disease. Out of 72 initially lepromin-negative contacts administered Mycobacterium w vaccine and followed up, the cumulative percentages show that 53 (73.6%) converted to positivity after a single dose, 10 (87.5%) after a second dose and 67 (93.1%) after the third dose. The incidence of new cases with leprosy was 8 out of 231 (3.46%) among lepromin-positive contacts and 5 out of 93 (5.38%) among lepromin-negative contacts administered Mycobacterium w vaccine. Among 231 lepromin-positive contacts, the new cases occurred in those with a 1+ and 2+ lepromin response only, and no case occurred among 51 contacts with a 3+ lepromin response. The incidence among lepromin-positive contacts in this study (3.46%) was similar to the observations in two other studies: 3.2% by Dharmendra, et al. and 6.9% by Chaudhary, et al. However, the incidence among lepromin-negative contacts administered Mycobacterium w vaccine was significantly lower than that observed among lepromin-negative contacts not administered any vaccination in the other two studies (14.1% by Dharmendra, et al. and 29.0% by Chaudhary, et al.). To conclude, although a study of small sample size, the preliminary evaluation indicates that administration of Mycobacterium w vaccine seems to have the potential to reduce the incidence of leprosy among household contacts of leprosy patients. More explicit results about the vaccine will be available from the ongoing field trials in Kanpur Dehat in the near future.
authors.affiliation: National Institute of Immunology, New Delhi, India.
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: H K
authors.initials: HK
authors.lastname: Kar
authors.forename: H
authors.initials: H
authors.lastname: Kaur
authors.forename: R S
authors.initials: RS
authors.lastname: Misra
authors.forename: A
authors.initials: A
authors.lastname: Mukherjee
authors.forename: R
authors.initials: R
authors.lastname: Mukherjee
authors.forename: R
authors.initials: R
authors.lastname: Rani
mesh_terms: D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016358:Contact Tracing; D005500:Follow-Up Studies; D006801:Humans; D007916:Lepromin; D007918:Leprosy / Q000276:immunology / Q000517:prevention & control / Q000635:transmission*; D009161:Mycobacterium / Q000276:immunology*; D010865:Pilot Projects
chemical_list: D001428:Bacterial Vaccines; D007916:Lepromin