title: Short-term hemodynamic effects of transjugular retrograde obliteration of gastric varices with gastrorenal shunt.
abstract: OBJECTIVE
  The purpose of this study was to investigate the short-term effects on portal hemodynamics of transjugular retrograde obliteration (TJO) of gastric varices with gastrorenal shunt.
  
  
  METHODS
  Thirty patients with gastric varices and a gastrorenal shunt were included in this study. The patients ranged in age from 42 to 75 years (16 men and 14 women), and according to Child's classification, class A, B and C cirrhosis was seen in 1, 13 and 16 patients, respectively. The portal blood flow was measured by an ultrasonic duplex Doppler system, and the wedged hepatic venous pressure was measured by hepatic venous catheterization, before and after TJO.
  
  
  RESULTS
  Complete obliteration of the gastrorenal shunt and gastric varices was revealed by retrograde inferior phrenic venography and computed tomography after TJO in all cases. The wedged hepatic venous pressure was significantly increased the day after TJO compared with that before therapy (257 +/- 71 vs. 307 +/- 73 mm H(2)O, p < 0.01). The portal venous flow was significantly increased 1 week after TJO compared with that before therapy (744 +/- 190 vs. 946 +/- 166 ml/min, p < 0.01). The serum albumin levels before and after TJO were 3.0 +/- 0.4 and 3.1 +/- 0.5 g/dl, respectively, and the total bilirubin levels were 1.5 +/- 0.7 and 1. 5 +/- 0.8 mg/dl, respectively, neither of these parameters changing significantly. The plasma ammonia levels before and after TJO were 109 +/- 62 and 67 +/- 31 microg/dl, and the indocyanine green retention rates at 15 min were 31 +/- 13 and 24 +/- 13%, both showing a significant change (p < 0.01 and p < 0.05, respectively).
  
  
  CONCLUSIONS
  We conclude that TJO increases portal blood flow which contributes to the decrease in plasma ammonia levels and the indocyanine green retention rate, although increasing the wedged hepatic venous pressure.
authors.affiliation: Department of Surgery, Kuniyoshi Hospital, Kochi, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Chikamori
authors.forename: N
authors.initials: N
authors.lastname: Kuniyoshi
authors.forename: S
authors.initials: S
authors.lastname: Shibuya
authors.forename: Y
authors.initials: Y
authors.lastname: Takase
mesh_terms: D000328:Adult; D000368:Aged; D021721:Balloon Occlusion; D001783:Blood Flow Velocity; D003097:Collateral Circulation; D004621:Embolization, Therapeutic; D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006439:Hemodynamics; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011168:Portal System / Q000503:physiopathology*; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000502:physiology; D012082:Renal Veins; D012212:Rheology; D013270:Stomach / Q000098:blood supply; D014463:Ultrasonography; D014690:Venous Pressure