Site of administration and duration of feeding oleamide to cattle on feed intake and ruminal fatty acid concentrations.
Two experiments were conducted to determine effects of oleamide on feed intake and ruminal fatty acids when the oleamide was introduced in the feed vs through a ruminal fistula (Exp. 1) or the oleamide was fed for an extended (9-wk) length of time (Exp. 2). In Exp. 1, four nonlactating Holstein cows, each fitted with a ruminal cannula, were fed four diets in a 4 x 4 Latin square design. Each period lasted 2 wk. Diets consisted of 48% corn silage and 52% concentrate on a DM basis. One diet contained no added fat (control) and a second diet contained 4.2% oleic acid. The remaining two diets were designed to expose cows to 4.2% amide (as oleamide) either through the feed (AF) or by administering oleamide into the rumen (AR) each day through the ruminal cannula. The AF diet reduced DMI similarly to results reported previously for lactating dairy cows and sheep. Intake of the oleic acid diet was intermediate between the control and AF diets. Dry matter intake was reduced by AR similarly to the AF diet. The acetate:propionate ratio in samples of ruminal contents was reduced by oleic acid but not by AF or AR. In Exp. 2, 12 steers were divided into three equal groups of two Angus and two Simmental x Angus crosses, and each group was assigned a diet containing either no added fat (control), 4% oleamide, or 4% high-oleic canola oil. All steers had ad libitum access to feed and water. Dry matter intake by steers fed the canola oil diet was not different from that by steers fed the control diet when averaged over the first 3 wk, the last 3 wk, or over the entire 9-wk study. Oleamide reduced DMI 4 kg/d over the first 3 wk of the study. However, DMI of the oleamide diet consistently increased over the 9-wk study, resulting in wk 7 to 9 DMI that was not different from that of steers fed the control diet. These results show that the reduction in feed intake when oleamide is added to cattle rations can be attributed more to physiological responses than to an undesirable unique taste or odor of the oleamide. In finishing beef steers, the decreased intake induced by oleamide was most severe during the first 1 or 2 wk of feeding but gradually lessened over time until it nearly returned to normal by wk 9.
Jenkins
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Department of Animal and Veterinary Sciences, Clemson University, SC 29634, USA. tjkns@Clemson.edu
Thompson
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CE
Bridges
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WC
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002417:Cattle / Q000378:metabolism*; D002149:Energy Intake / Q000187:drug effects*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D005503:Food Additives / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D019301:Oleic Acid / Q000494:pharmacology; D009829:Oleic Acids / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D012417:Rumen / Q000378:metabolism*
D005227:Fatty Acids; D005503:Food Additives; D009829:Oleic Acids; D019301:Oleic Acid; C029407:oleylamide