title: Mast cell tumor in the nasal cavity of a dog.
abstract: An 11-year-old male Shetland sheepdog displayed epistaxis and nasal discharge from the left nasal foramen. Cytological examination of a smear sample obtained by rhinotomy revealed neoplastic mast cells in the nasal cavity, a definitive diagnostic sign of mast cell tumor. The case was treated by surgery combined with radiotherapy and chemotherapy. Eighteen days after the last treatment, marked enlargement of the mandibular lymph nodes and facial edema developed, and the dog was euthanized at the owner's request. At necropsy, metastatic proliferation of mast cells was confirmed in the lymph nodes and liver, but no neoplastic mast cells were observed in the nasal cavity.
authors.affiliation: Department of Veterinary Science, Faculty of Agriculture, Miyazaki University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Naganobu
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: R
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: F
authors.initials: F
authors.lastname: Ohashi
authors.forename: K
authors.initials: K
authors.lastname: Kubo
authors.forename: M
authors.initials: M
authors.lastname: Aoki
authors.forename: M
authors.initials: M
authors.lastname: Kuwamura
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Matsuyama
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004283:Dog Diseases / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D008297:Male; D012515:Mast-Cell Sarcoma / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D009296:Nasal Cavity / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D011239:Prednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone