title: Mouse Nov gene is expressed in hypaxial musculature and cranial structures derived from neural crest cells and placodes.
abstract: NOV is a member of an emerging family of proteins, the CCN family, implicated in the control of cell growth and differentiation. During mouse development Nov is expressed predominantly in the skeletal and visceral muscles and in the nervous system. Transcripts are first detected in muscle precursor cells from 10.0 dpc and later in the hypaxial muscles of the trunk and shoulder/hip, as well as in the muscles of the head and in the smooth muscle of major vessels. In the nervous system, Nov is observed in the somatic motor neurons of the spinal cord from 12.5 dpc and in cranial structures derived either from neural crest cells or placodes, including V, VII, VIII, and IX ganglia and olfactory neuroepithelia.
authors.affiliation: National Institute for Medical Research, Mill Hill, London, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Natarajan
authors.forename: E
authors.initials: E
authors.lastname: Andermarcher
authors.forename: P N
authors.initials: PN
authors.lastname: Schofield
authors.forename: C A
authors.initials: CA
authors.lastname: Boulter
mesh_terms: D000818:Animals; D055513:Connective Tissue Growth Factor; D018507:Gene Expression Regulation, Developmental; D017874:Immediate-Early Proteins; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009046:Motor Neurons / Q000378:metabolism; D018482:Muscle, Skeletal / Q000196:embryology / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000196:embryology / Q000378:metabolism; D055514:Nephroblastoma Overexpressed Protein; D009432:Neural Crest / Q000196:embryology* / Q000378:metabolism*; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012886:Skull / Q000196:embryology / Q000378:metabolism; D013116:Spinal Cord / Q000196:embryology / Q000378:metabolism
chemical_list: C526318:CCN2 protein, mouse; C526320:Ccn3 protein, mouse; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D055514:Nephroblastoma Overexpressed Protein; D011506:Proteins; D012333:RNA, Messenger; D055513:Connective Tissue Growth Factor