IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.
We report identification of interleukin (IL)-17E, a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported ligand-receptor relationships. Murine EVI27 was identified through its location at a common site of retroviral integration in BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression in kidney with moderate expression in multiple other organs, whereas IL-17E mRNA was detected at very low levels in several peripheral tissues. IL-17E induces activation of NF-kappaB and stimulates production of the proinflammatory chemokine IL-8.
Lee
J
J
Department of Molecular Biology, Genentech Inc., San Francisco, California 94080, USA.
Ho
W H
WH
Maruoka
M
M
Corpuz
R T
RT
Baldwin
D T
DT
Foster
J S
JS
Goddard
A D
AD
Yansura
D G
DG
Vandlen
R L
RL
Wood
W I
WI
Gurney
A L
AL
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D017124:Conserved Sequence; D005260:Female; D015723:Gene Library; D006801:Humans; D020381:Interleukin-17 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D016209:Interleukin-8 / Q000096:biosynthesis; D007668:Kidney / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology / Q000821:virology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D009928:Organ Specificity; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D018123:Receptors, Interleukin / Q000235:genetics / Q000378:metabolism*; D053722:Receptors, Interleukin-17; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014158:Transcription, Genetic; D014162:Transfection; D016662:Virus Integration
C109985:IL17RA protein, human; C491673:Il17ra protein, mouse; D020381:Interleukin-17; D016209:Interleukin-8; D016328:NF-kappa B; D020033:Protein Isoforms; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D053722:Receptors, Interleukin-17; D011994:Recombinant Proteins