title: Using patient-reportable clinical history factors to predict myocardial infarction.
abstract: Using a derivation data set of 1253 patients, we built several logistic regression and neural network models to estimate the likelihood of myocardial infarction based upon patient-reportable clinical history factors only. The best performing logistic regression model and neural network model had C-indices of 0.8444 and 0.8503, respectively, when validated on an independent data set of 500 patients. We conclude that both logistic regression and neural network models can be built that successfully predict the probability of myocardial infarction based on patient-reportable history factors alone. These models could have important utility in applications outside of a hospital setting when objective diagnostic test information is not yet be available.
authors.affiliation: Clinical Information Systems Research & Development, Partners HealthCare System, Boston, MA, USA. sjwang@partners.org
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Ohno-Machado
authors.forename: H S
authors.initials: HS
authors.lastname: Fraser
authors.forename: R L
authors.initials: RL
authors.lastname: Kennedy
mesh_terms: D016208:Databases, Factual; D020000:Decision Support Systems, Clinical; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D016571:Neural Networks, Computer