title: Osseous integration of bovine hydroxyapatite ceramic in metaphyseal bone defects of the distal radius.
abstract: Hydroxyapatite ceramic made of bovine spongiosa was used as structural support material in a prospective study to correct bone defects experienced after reduction in distal radius fractures. The study took place over a 3-year period (1992-1999) and comprised 14 patients. Osseous integration was analyzed via biopsies and magnetic resonance imaging. Long-term follow-up monitoring involving magnetic resonance imaging in 13 of the 14 patients showed fibrovascular growth within incorporated hydroxyapatite material. Osseous integration was demonstrated in magnetic resonance images by gadolinium uptake and by the presence of osteoid layers and endothelialized vessels. Hydroxyapatite ceramic offers a biologically acceptable alternative to autologous bone when augmenting distal radius fracture fixation.
authors.affiliation: Departments of Surgery, Radiology, and Pathology, Klinikum rechts der Isar, Technische Universität München, München, Germany.
authors.forename: K D
authors.initials: KD
authors.lastname: Werber
authors.forename: R B
authors.initials: RB
authors.lastname: Brauer
authors.forename: W
authors.initials: W
authors.lastname: Weiss
authors.forename: K
authors.initials: K
authors.lastname: Becker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D018786:Bone Substitutes; D002417:Cattle; D005260:Female; D005593:Fracture Fixation, Internal; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016348:Osseointegration / Q000502:physiology*; D011183:Postoperative Complications / Q000473:pathology / Q000601:surgery; D011446:Prospective Studies; D011884:Radius / Q000473:pathology / Q000601:surgery; D011885:Radius Fractures / Q000473:pathology / Q000601:surgery*; D012086:Reoperation; D014954:Wrist Injuries / Q000473:pathology / Q000601:surgery*
chemical_list: D018786:Bone Substitutes; C104266:endobon