title: Apoplexy of pituitary macroadenoma after combined test of anterior pituitary function.
abstract: Pituitary apoplexy has been reported as a very rare complication of combined tests of anterior pituitary function and of TRH or gonadotropin-releasing hormone (GnRH) administration in pituitary tumor. A 34-year-old man with a GH-secreting pituitary macroadenoma and diabetes mellitus received an injection of 400 microg TRH, 100 microg GnRH, and 0.15 U/Kg regular insulin. Twenty minutes later, he complained of a severe headache and vomited. Visual acuity and visual field did not change and his headache was persistent during the next 24 hours of conservative management. Magnetic resonance imaging (MRI) of the sella turcica done the day after the event showed definitive elevation of the optic chiasm and slight enlargement of tumor and focal areas of mixed high signal and low signal intensities in the macroadenoma on noncontrast T1-weighted images. Headache subsided markedly within a day of octreotide therapy. Transsphenoidal removal of the pituitary tumor was performed 9 days after the hormone study. Ischemic necrosis and hemorrhage were confirmed in the acidophilic adenoma with positive immunostaining for GH. Postoperative course was uneventful and his serum insulin-like growth factor-1 (IGF-1) level and blood glucose levels were normalized. Three months after the surgery the dynamic test was repeated without adverse effects. To our knowledge, this is a very rare case of apoplexy of GH-secreting pituitary adenoma after a combined stimulation test of anterior pituitary function.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea.
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.forename: M Y
authors.initials: MY
authors.lastname: Chung
authors.forename: D J
authors.initials: DJ
authors.lastname: Chung
authors.forename: J M
authors.initials: JM
authors.lastname: Kim
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Nam
authors.forename: C S
authors.initials: CS
authors.lastname: Park
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000328:Adult; D006801:Humans; D008297:Male; D010899:Pituitary Apoplexy / Q000150:complications / Q000209:etiology*; D010901:Pituitary Function Tests / Q000009:adverse effects; D010903:Pituitary Gland, Anterior / Q000503:physiopathology*; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology*