title: S100-annexin complexes: some insights from structural studies.
abstract: Several annexins have been shown to bind proteins that belong to the S100 calcium-binding protein family. The two best-characterized complexes are annexin II with p11 and annexin I with S100C, the former of which has been implicated in membrane fusion processes. We have solved the crystal structures of the complexes of p11 with annexin II N-terminus and of S100C with annexin I N-terminus. Using these structural results, as well as electron microscopy observations of liposome junctions formed in the presence of such complexes (Lambert et al., 1997 J Mol Biol 272, 42-55), we propose a computer generated model for the entire annexin II/p11 complex.
authors.affiliation: LURE (CNRS, CEA, MENRT), Centre Universitaire Paris-Sud, Orsay, 91898, France. anita@lure.u-psud.fr
authors.forename: A
authors.initials: A
authors.lastname: Lewit-Bentley
authors.forename: S
authors.initials: S
authors.lastname: Réty
authors.forename: J
authors.initials: J
authors.lastname: Sopkova-de Oliveira Santos
authors.forename: V
authors.initials: V
authors.lastname: Gerke
mesh_terms: D017306:Annexin A2 / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D019281:Dimerization; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D009418:S100 Proteins / Q000737:chemistry* / Q000378:metabolism; D000099248:S100 Calcium Binding Protein A10
chemical_list: D017306:Annexin A2; D010455:Peptides; D009418:S100 Proteins; D000099248:S100 Calcium Binding Protein A10