[Somastostatin and growth hormone in preventing liver damage due to acute necrotizing pancreatitis].
OBJECTIVE
To study the role of somastostatin and growth hormone in preventing liver damage due to ANP.


METHODS
The roles of inflammatory mediators (Endotoxin, Amylase, TNF alpha) were investigated in ANP model by retrograde injection of 3.5% sodium taurocholate 2.5 ml/kg into the pancreatic duct, and TNF alpha mRNA in the liver after ANP was observed by reverse transcriptase-polymerase chain reaction. Besides, the effects of somastostain and growth hormone were also observed.


RESULTS
ANP caused remarkable elevation of those inflammatory mediators, being positively correlated with the development of pancreas and liver damage. Somastostain and growth hormone inhibited the inflammatory mediates and TNF alpha mRNA overexpression and reduced the damage to the pancreas and liver.


CONCLUSIONS
TNF alpha plays an important role in ANP progression, and somastostatin and growth hormone may prevent the development and progression of liver damage due to ANP.
Zhang
Q
Q
Department of Surgery, Shanghai Medical University.
Ni
Q
Q
Cai
D
D
D000818:Animals; D013006:Growth Hormone / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010179:Pancreas / Q000473:pathology; D019283:Pancreatitis, Acute Necrotizing / Q000473:pathology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D013004:Somatostatin; D013006:Growth Hormone