title: Osteoarticular allograft in surgery for high-grade malignant tumours of bone.
abstract: We assessed the results of 17 limb-salvage procedures using osteoarticular allografts after wide resection of high-grade malignant bone tumours. All patients received chemotherapy. At the five-year follow-up, three patients had died from metastases. The allografts survived for five years in only seven patients all of whom had good function, ranging from 73% to 90% of normal. The allografts were removed because of fracture in seven patients and infection in one, and in all of these a second limb-salvage procedure was undertaken. With such a low rate of survival of osteoarticular allografts, we believe that their use in the management of high-grade malignant bone tumours should, at best, be considered a temporary solution.
authors.affiliation: Department of Orthopaedics, University Hospital, Münster, Germany.
authors.forename: R W
authors.initials: RW
authors.lastname: Rödl
authors.forename: T
authors.initials: T
authors.lastname: Ozaki
authors.forename: C
authors.initials: C
authors.lastname: Hoffmann
authors.forename: F
authors.initials: F
authors.lastname: Böttner
authors.forename: N
authors.initials: N
authors.lastname: Lindner
authors.forename: W
authors.initials: W
authors.lastname: Winkelmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001843:Bone Cements / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D002648:Child; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery; D005500:Follow-Up Studies; D050723:Fractures, Bone / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D006811:Humerus / Q000601:surgery; D008297:Male; D012516:Osteosarcoma / Q000556:secondary / Q000601:surgery*; D012086:Reoperation; D016879:Salvage Therapy; D013530:Surgical Wound Infection / Q000209:etiology; D013977:Tibia / Q000601:surgery; D014184:Transplantation, Homologous
chemical_list: D001843:Bone Cements