title: Asperger's syndrome, X-linked mental retardation (MRX23), and chronic vocal tic disorder.
abstract: Pervasive developmental disorders are severe disorders of development with no consistent neurobiologic etiology and most often an idiopathic etiology. We report a 12-year-old male who met criteria for a pervasive developmental disorder (Asperger's syndrome) and a chronic tic disorder. The child also has an X-linked cognitive impairment (MRX23). The presence of tic symptomatology, pervasive developmental disorder, and fragile X syndrome has previously been reported. Since no singular etiology for Asperger's syndrome has been found, the possibility of other cases of Asperger's syndrome occurring with concurrent abnormalities on the X chromosome should be considered by clinicians, especially if tic symptomatology is present.
authors.affiliation: Child Evaluation and Treatment Program, Grand Forks, North Dakota 58202, USA.
authors.forename: E
authors.initials: E
authors.lastname: Searcy
authors.forename: L
authors.initials: L
authors.lastname: Burd
authors.forename: J
authors.initials: J
authors.lastname: Kerbeshian
authors.forename: A
authors.initials: A
authors.lastname: Stenehjem
authors.forename: L A
authors.initials: LA
authors.lastname: Franceschini
mesh_terms: D020817:Asperger Syndrome / Q000150:complications*; D002648:Child; D002908:Chronic Disease; D003072:Cognition Disorders / Q000175:diagnosis; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications* / Q000235:genetics*; D009483:Neuropsychological Tests; D010375:Pedigree; D012720:Severity of Illness Index; D020323:Tics / Q000150:complications* / Q000503:physiopathology*; D014827:Vocal Cords / Q000503:physiopathology*; D014960:X Chromosome / Q000235:genetics*