title: Analysis of static pulmonary mechanics helps to identify functional defects in survivors of acute respiratory distress syndrome.
abstract: OBJECTIVE
  To assess the utility of static lung pressure-volume measurements in identifying and categorizing pulmonary function test defects in survivors of acute respiratory distress syndrome (ARDS).
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Pulmonary function laboratory at a tertiary referral hospital in northern India.
  
  
  METHODS
  Six survivors of ARDS reporting for their first follow-up visit after discharge.
  
  
  RESULTS
  Spirometry and whole body plethysmography were performed to evaluate lung volumes and to collect static lung pressure-volume data; the latter were subjected to monoexponential analysis. Three patients had a restrictive ventilatory defect as evidenced by diminished vital capacity and total lung capacity, but only one had reduced static lung compliance. The other two patients had reduced recoil pressure at total lung capacity, suggestive of respiratory muscle weakness. Two other patients with normal lung volumes had reduced static lung compliance. Exponential analysis of pressure-volume data in the three patients with reduced static lung compliance was consistent with reduced distensibility and loss of lung units in one patient each. Additionally, two patients had high values for shape constant of the exponential curve, indicative of air space distention.
  
  
  CONCLUSIONS
  Detailed analysis of static pressure-volume data can identify pulmonary function abnormality and categorize the dominant mechanism responsible for restrictive ventilatory defects in survivors of ARDS, even in patients with normal lung volumes. In addition to lung fibrosis, neuromuscular weakness also contributes to decline in pulmonary function.
authors.affiliation: Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: A N
authors.initials: AN
authors.lastname: Aggarwal
authors.forename: D
authors.initials: D
authors.lastname: Gupta
authors.forename: D
authors.initials: D
authors.lastname: Behera
authors.forename: S K
authors.initials: SK
authors.lastname: Jindal
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008170:Lung Compliance; D008297:Male; D018908:Muscle Weakness / Q000150:complications; D010993:Plethysmography, Whole Body; D011658:Pulmonary Fibrosis / Q000150:complications; D012128:Respiratory Distress Syndrome / Q000150:complications / Q000401:mortality* / Q000473:pathology / Q000503:physiopathology*; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics; D013147:Spirometry; D016019:Survival Analysis; D013997:Time Factors; D014797:Vital Capacity