title: Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer.
abstract: Tangeretin, a molecule present in citrus fruits and in certain 'natural' menopausal medications, is an effective tumour growth and invasion inhibitor in vitro of human MCF 7/6 breast cancer cells. However, when added to the drinking water of MCF 7/6 tumour-bearing mice it neutralises the beneficial tumour-suppressing effect of tamoxifen. Tangeretin reduces the number of natural killer cells. This may explain why the beneficial suppressive effect of tangeretin on MCF 7/6 cell proliferation in vitro is completely counteracted in vivo.
authors.affiliation: Department of Gynaecological Oncology, University Hospital, De Pintelaan 185, 9000, Ghent, Belgium. hermann.depypere@rug.ac.be
authors.forename: H T
authors.initials: HT
authors.lastname: Depypere
authors.forename: M E
authors.initials: ME
authors.lastname: Bracke
authors.forename: T
authors.initials: T
authors.lastname: Boterberg
authors.forename: M M
authors.initials: MM
authors.lastname: Mareel
authors.forename: M
authors.initials: M
authors.lastname: Nuytinck
authors.forename: K
authors.initials: K
authors.lastname: Vennekens
authors.forename: R
authors.initials: R
authors.lastname: Serreyn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018931:Antineoplastic Agents, Hormonal / Q000037:antagonists & inhibitors* / Q000627:therapeutic use; D005260:Female; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology*; D018565:Food-Drug Interactions; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D013629:Tamoxifen / Q000037:antagonists & inhibitors* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D047309:Flavones; D005419:Flavonoids; D013629:Tamoxifen; C059006:tangeretin