[Study of dimerization of polysynthetic derivatives of the antibiotic eremomycin by ESI MS and its role in elucidating antibacterial activity].
The dimerization constants for glycopeptide antibiotics vancomycin, ristocetin, and eremomycin and nine semisynthetic eremomycin derivatives were determined by the electrospray ionization mass spectrometry; the constants for natural antibiotics turned out to be close to those previously determined by NMR. No correlation between these dimerization constants and antibacterial activities of all the compounds toward the clinical strains of Gram-positive bacteria was found.
Mirgorodskaia
O A
OA
Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
Olsuf'eva
E N
EN
Kolume
D E
DE
Joergensen
T J
TJ
Roepstorff
P
P
Pavlov
A Iu
AIu
Miroshnikova
O V
OV
Preobrazhenskaia
M N
MN
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D019281:Dimerization; D006020:Glycopeptides; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D021241:Spectrometry, Mass, Electrospray Ionization
D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C053759:eremomycin