title: Leukoencephalitis and vasculitis with perivascular demyelination in a Weimaraner dog.
abstract: Aseptic and noninfectious diseases of the central nervous system are being recognized with increasing frequency. After multiple episodes of neurologic illness, this 7-year-old Weimaraner dog was euthanatized and submitted for postmortem examination. Lesions in the central nervous system were found mainly in the white matter of the cerebral cortex and cervical spinal cord and represented acute and more chronic injury. Necrotizing vasculitis with fibrinoid change and a marked neutrophilic infiltrate dominated the acute lesions. More chronic changes consisted of perivascular demyelination and accumulation of foamy macrophages with positive staining for myelin. An immune-complex (Arthus-type) vasculitis is suspected.
authors.affiliation: Escuela de Medicina Veterinaria, Departmento de Patología, Universidad Nacional, Heredia, Costa Rica.
authors.forename: A
authors.initials: A
authors.lastname: Berrocal
authors.forename: D L
authors.initials: DL
authors.lastname: Montgomery
authors.forename: M
authors.initials: M
authors.lastname: Pumarola
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005065:Euthanasia / Q000662:veterinary; D009336:Necrosis; D013116:Spinal Cord / Q000473:pathology; D020293:Vasculitis, Central Nervous System / Q000473:pathology / Q000662:veterinary*