title: The effect of resecting the primary tumour on the Doppler Perfusion Index in patients with colorectal cancer.
abstract: OBJECTIVE
  In patients undergoing apparently curative resection for colorectal cancer, an elevated Doppler Perfusion Index (DPI; ratio of hepatic arterial to total liver blood flow) before surgery is associated with a high risk of recurrence. The role of the primary tumour in inducing and sustaining these blood flow changes is unknown. The aim of this study was to assess the impact of removing the primary tumour on the DPI.
  
  
  METHODS
  Using duplex/colour Doppler sonography, the DPI was measured both before and after surgery (median, 9 months) in 14 patients undergoing apparently curative resection for colorectal cancer.
  
  
  RESULTS
  In the five patients with a normal pre-operative DPI (< 0.30), there was no significant change following surgery. In the nine patients with an abnormal pre-operative DPI, there was a small but significant fall from 0.38 (SEM 0.02) to 0.33 (0.02) following surgery (P = 0.04). However, DPI values remained abnormally elevated in seven of these nine patients.
  
  
  CONCLUSIONS
  These results suggest that the primary tumour plays a relatively minor role in inducing an abnormally elevated DPI in patients undergoing apparently curative resection for colorectal cancer.Oppo, K. (2000). Clinical Radiology55, 791-793.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, UK.
authors.forename: K
authors.initials: K
authors.lastname: Oppo
authors.forename: E
authors.initials: E
authors.lastname: Leen
authors.forename: W J
authors.initials: WJ
authors.lastname: Angerson
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006499:Hepatic Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000098:blood supply / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000503:physiopathology; D011184:Postoperative Period; D018615:Ultrasonography, Doppler, Color; D018616:Ultrasonography, Doppler, Duplex