Effect of intracerebroventricular administration of soybean lecithin transphosphatidylated phosphatidylserine on scopolamine-induced amnesic mice.
The effect of intracerebroventricularly administered soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) on memory impairment was evaluated by a passive avoidance task. SB-tPS significantly prolonged the step-through latency induced by scopolamine treatment as in our previous report where SB-tPS was orally administered. The same doses of soybean phosphatidylcholine were ineffective. This result indicates that SB-tPS can act on the brain without any peripheral modification.
Suzuki
S
S
Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan.
Kataoka
A
A
Furushiro
M
M
D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D004347:Drug Interactions; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D010713:Phosphatidylcholines / Q000627:therapeutic use; D010718:Phosphatidylserines / Q000737:chemistry / Q000627:therapeutic use*; D012601:Scopolamine; D013025:Glycine max / Q000737:chemistry*
D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D012601:Scopolamine