[Effect of ascorbic acid on production of nitric oxide by leukocytes].
The effect of ascorbic acid on suspensions of blood formic elements was studied by the ESR method. It was shown that incubation of a suspension of formic blood elements in the presence of ascorbic acid leads to the appearance of nitric oxide, which is produced by leukocytes and partially probably by thrombocytes. The formation of nitric oxide is evidenced by the appearance of nitrosyl complexes heme-NO. In this case, hemoglobin of erythrocytes serves as a natural trap for nitric oxide.
Kuroteva
Z V
ZV
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
Baĭler
L M
LM
Zhumabaeva
T T
TT
D001205:Ascorbic Acid / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*
D006454:Hemoglobins; D009569:Nitric Oxide; D001205:Ascorbic Acid