title: Influence of bilateral olfactory bulbectomy on the circadian rhythm of phagocytic activity and phagocytic response in mice.
abstract: The bilateral olfactory bulbectomy (OB) has been proposed as an animal model of depression. The present study, carried out on NMRI adult male mice kept on a natural LD 12:12 regimen, aimed to assess the influence of OB on the circadian rhythm of blood neutrophils phagocytosis. The results show that OB mice present an about 20% reduction of the basal phagocytic activity at 09.00 hrs, 15.00 hrs. and 21.00 hrs. and a 40% reduction at 03.00 hrs., leading to a flattened circadian phagocytic curve. The results indicate that bilateral olfactory bulbectomy depresses phagocytosis, alters its circadian rhythm and consequently increases susceptibility to infections.
authors.affiliation: Physiology Dept., University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Saulea
authors.forename: M
authors.initials: M
authors.lastname: Hriscu
authors.forename: N
authors.initials: N
authors.lastname: Vidraşcu
authors.forename: I
authors.initials: I
authors.lastname: Baciu
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000276:immunology*; D003714:Denervation; D007839:Functional Laterality; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015213:Neuroimmunomodulation / Q000502:physiology; D009504:Neutrophils / Q000166:cytology* / Q000276:immunology; D009830:Olfactory Bulb / Q000276:immunology* / Q000601:surgery*; D010587:Phagocytosis / Q000276:immunology*; D012903:Smell / Q000276:immunology