title: Abeta-generating enzymes: recent advances in beta- and gamma-secretase research.
authors.affiliation: Amgen Inc, Thousand Oaks, California 91320, USA. rvassar@amgen.com
authors.forename: R
authors.initials: R
authors.lastname: Vassar
authors.forename: M
authors.initials: M
authors.lastname: Citron
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000096:biosynthesis*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000235:genetics / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D053764:Presenilin-1; D053766:Presenilin-2; D011499:Protein Processing, Post-Translational; D051880:Receptors, Notch; D015398:Signal Transduction
chemical_list: D016229:Amyloid beta-Peptides; D046911:Macromolecular Substances; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D051880:Receptors, Notch; C413604:nicastrin protein; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509284:BACE2 protein, human; C509280:BACE1 protein, human; C509282:Bace1 protein, mouse