Neutrophilic thrombophagocytosis.
Thrombocytopenia as a complication of B-cell lymphoma usually results from the removal of platelets from the circulation by splenic and hepatic mononuclear phagocytes.1,2 In the present paper, we describe a case of B-cell lymphoma with thrombocytopenia in which the platelets were phagocytosed by the patient's own neutrophilic granulocytes. This finding suggests that neutrophilic granulocytes actively participate in immune platelet clearance.
Lee
J C
JC
Department of Pathology, St Joseph Regional Health Center, Bryan, TX, USA.
Tripathy
K
K
D000368:Aged; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000473:pathology; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology* / Q000502:physiology; D010587:Phagocytosis; D011994:Recombinant Proteins; D013921:Thrombocytopenia / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim