Use of evoked potentials to objectively differentiate between selective vulnerability of cochlear and vestibular end organ function.
Auditory nerve brainstem evoked responses (ABR) have been used for several decades to investigate cochlear function. Recently techniques have been developed to elicit similar recordings from the vestibular end organs - short latency vestibular evoked potentials (VsEPs). Both ABR and VsEP reflect appropriate end organ function and may therefore be used to investigate the vulnerability of these end organs to various experimental insults, such as noise exposure and ototoxic drugs.
Freeman
S
S
Department of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Priner
R
R
Mager
M
M
Sichel
J Y
JY
Perez
R
R
Elidan
J
J
Sohmer
H
H
D000818:Animals; D003051:Cochlea / Q000187:drug effects / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006801:Humans; D009622:Noise; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000502:physiology*