Lymphomatoid papulosis associated with both severe hypereosinophilic syndrome and CD30 positive large T-cell lymphoma.
BACKGROUND
Previous reports have found an association between lymphomatoid papulosis and hypereosinophilic syndrome, as well as lymphomatoid papulosis and lymphoma. In the current study the authors report what to their knowledge is the first reported case of these three diseases occurring simultaneously in the same patient.


METHODS
The authors followed the clinical course of a 64-year-old man with lymphomatoid papulosis associated with severe hypereosinophilic syndrome complicated by involvement of the lungs and heart.


RESULTS
After 6 years of follow-up, the patient developped a large T-cell, CD30 positive lymphoma. The bone marrow biopsy was typical of hypereosinophilic syndrome associated with fibrosis, with focal lymphomatous infiltrates comprised of large cells resembling the type A cells of lymphomatoid papulosis. Complete remission of the lymphoma was obtained with chemotherapy.


CONCLUSIONS
This exceptional case report suggests a link between the three diseases. Lymphomatoid papulosis belongs to the spectrum of CD30 positive lymphoproliferative disorders and CD30 positive lymphocytes of lymphomatoid papulosis are known to have a Th2 profile with possible secretion of eosinopoietic cytokines.
Granel
B
B
Service de Médecine Interne, Hôpital de la Timone, Marseille Cedex, France.
Serratrice
J
J
Swiader
L
L
Horshowski
N
N
Blaise
D
D
Vey
N
N
Metras
D
D
Habib
G
G
Disdier
P
P
Weiller
P J
PJ
D001854:Bone Marrow Cells / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology; D017730:Ki-1 Antigen / Q000032:analysis*; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology / Q000473:pathology; D017731:Lymphomatoid Papulosis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged
D017730:Ki-1 Antigen