Amiodarone-induced thyrotoxicosis type 2: a case report and review of the literature.
Amiodarone-induced thyrotoxicosis (AIT) is not an uncommon complication in countries with low iodine intake. Two types of AIT have been described. Type 1 is associated with an underlying disorder of the gland that becomes clinically evident because of the high intrathyroidal iodine content, which acts as a trigger for hyperthyroidism. Type 2 is characterized by an ongoing inflammatory process of the thyroid, with derangement of the parenchyma causing the release of thyroid hormones into the circulation. Yet, there are no definitive tools for the differential diagnosis of these two entities, and the therapeutic approach is still a subject of controversy. A case of AIT type 2 successfully treated with steroids is described followed by a review of the literature.
Benbassat
C A
CA
Endocrine Institute, Rabin Medical Center, Petah Tikva, Israel. carlosb@netvision.net.il
Mechlis-Frish
S
S
Cohen
M
M
Blum
I
I
D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013963:Thyroid Hormones / Q000097:blood*; D013971:Thyrotoxicosis / Q000097:blood / Q000139:chemically induced*
D000889:Anti-Arrhythmia Agents; D013963:Thyroid Hormones; D000638:Amiodarone