title: Prostatic levels of fatty acids and the histopathology of localized prostate cancer.
abstract: OBJECTIVE
  The consumption of various fatty acids has been associated with advanced stage and fatal prostate cancer. While numerous mechanisms have been postulated, to our knowledge there physiological data linking exposure and prognosis in humans are lacking. We examined prostatic levels of individual fatty acids in relation to the prevalence of histopathological characteristics associated with invasiveness and the risk of progression in 49 men undergoing radical prostatectomy for localized prostate cancer.
  
  
  METHODS
  Fatty acids were measured using capillary gas chromatography in fresh nonmalignant prostate tissue collected at surgery. Markers of invasiveness and increased risk of progression (Gleason sum 7 or greater, perineural invasion, anatomical or surgical margin involvement, extracapsular extension, seminal vesical involvement and stage T3 tumor) were evaluated separately. Each marker was dichotomized into a yes (case) and no (control) level with patients grouped accordingly. Mean concentrations were compared using the Wilcoxon rank sum test.
  
  
  RESULTS
  The percent of total prostatic polyunsaturated fat and polyunsaturated-to-saturated fat ratios were significantly lower in the presence of perineural invasion, seminal vesical involvement and stage T3 tumor (p = 0.02 to 0.049). alpha-Linolenic acid was significantly lower when tumor extended to an anatomical or surgical margin (p = 0.008). The omega-3 and omega-3-to-omega-6 fatty acid ratios were 1.5 to 3.3-fold lower in cases than in controls, reaching borderline significance in nearly all comparisons (p = 0.052 to 0.097). Saturated and monounsaturated fatty acids were not associated with the traits examined.
  
  
  CONCLUSIONS
  These data suggest that polyunsaturated fatty acids and perhaps essential fatty acids in particular help to regulate prostate carcinogenesis in humans.
authors.affiliation: Midwest Center for Health Services and Policy Research, Department of Veterans Affairs, Edward Hines, Jr. Hospital, Hines, Illinois, USA.
authors.forename: V L
authors.initials: VL
authors.lastname: Freeman
authors.forename: M
authors.initials: M
authors.lastname: Meydani
authors.forename: S
authors.initials: S
authors.lastname: Yong
authors.forename: J
authors.initials: J
authors.lastname: Pyle
authors.forename: R C
authors.initials: RC
authors.lastname: Flanigan
authors.forename: W B
authors.initials: WB
authors.lastname: Waters
authors.forename: E M
authors.initials: EM
authors.lastname: Wojcik
mesh_terms: D002849:Chromatography, Gas; D005227:Fatty Acids / Q000032:analysis*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011467:Prostate / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology
chemical_list: D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated