title: An automatic method to discriminate malignant masses from normal tissue in digital mammograms.
abstract: Specificity levels of automatic mass detection methods in mammography are generally rather low, because suspicious looking normal tissue is often hard to discriminate from real malignant masses. In this work a number of features were defined that are related to image characteristics that radiologists use to discriminate real lesions from normal tissue. An artificial neural network was used to map the computed features to a measure of suspiciousness for each region that was found suspicious by a mass detection method. Two data sets were used to test the method. The first set of 72 malignant cases (132 films) was a consecutive series taken from the Nijmegen screening programme, 208 normal films were added to improve the estimation of the specificity of the method. The second set was part of the new DDSM data set from the University of South Florida. A total of 193 cases (772 films) with 372 annotated malignancies was used. The measure of suspiciousness that was computed using the image characteristics was successful in discriminating tumours from false positive detections. Approximately 75% of all cancers were detected in at least one view at a specificity level of 0.1 false positive per image.
authors.affiliation: Department of Radiology, Radboud University Hospital, Nijmegen, The Netherlands.
authors.forename: G M
authors.initials: GM
authors.lastname: te Brake
authors.forename: N
authors.initials: N
authors.lastname: Karssemeijer
authors.forename: J H
authors.initials: JH
authors.lastname: Hendriks
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008327:Mammography / Q000295:instrumentation* / Q000379:methods*; D015233:Models, Statistical; D016571:Neural Networks, Computer; D012680:Sensitivity and Specificity; D013997:Time Factors