title: Amantadine monotherapy of chronic hepatitis C patients infected with genotype lb.
abstract: We aimed to test the efficacy of amantadine in chronic hepatitis C (CHC) patients infected with genotype b. Twenty patients completed treatment with amantadine HCl, 100 mg b.i.d., for 6 months. Non-sustained biochemical improvement was observed without loss of HCV-RNA. We conclude that amantadine monotherapy is not effective in CHC.
authors.affiliation: Department of Internal Medicine, Cerrahpasa Medical Faculty of Istanbul University, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Senturk
authors.forename: A
authors.initials: A
authors.lastname: Mert
authors.forename: M
authors.initials: M
authors.lastname: Akdogan
authors.forename: F
authors.initials: F
authors.lastname: Tabak
authors.forename: G
authors.initials: G
authors.lastname: Basaran
authors.forename: S
authors.initials: S
authors.lastname: Turkoglu
authors.forename: G
authors.initials: G
authors.lastname: Ozbay
authors.forename: S
authors.initials: S
authors.lastname: Badur
mesh_terms: D000293:Adolescent; D000328:Adult; D000547:Amantadine / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D017211:Treatment Failure
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D000547:Amantadine