Impairment of airway mucociliary transport in patients with sinobronchial syndrome: role of nitric oxide.
Nitric oxide (NO) produced within the respiratory tract can stimulate ciliary motility of airway epithelial cells and hence mucociliary transport. In this study, to determine the role of NO in mucociliary dysfunction in sinobronchial syndrome (SBS), we measured NO concentrations in the exhaled air by chemiluminescence analyzer and nasal clearance time (NCT) by saccharin test. Exhaled NO concentrations in patients with SBS were 39% of those in healthy nonsmokers and 55% of those in healthy smokers. The patients also showed prolonged NCT compared with healthy subjects, and there was a significant negative correlation between exhaled NO concentrations and NCT. Furthermore, concentrations of chloride (Cl) in the sputum supernatant were higher in SBS patients than in healthy subjects, and there was a significant negative correlation between sputum Cl concentrations and exhaled NO concentrations. These results suggest that airway mucociliary clearance is impaired in patients with SBS and that this impairment might result from the reduced production of NO and the impaired availability of the molecule in the mucociliary apparatus.
Tamaoki
J
J
First Department of Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan. jtamaoki@chl.twmu.ac.jp
Taira
M
M
Nishimura
K
K
Nakata
J
J
Nagai
A
A
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002925:Ciliary Motility Disorders / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009079:Mucociliary Clearance; D009569:Nitric Oxide / Q000378:metabolism* / Q000494:pharmacology; D012852:Sinusitis / Q000378:metabolism* / Q000503:physiopathology; D013183:Sputum / Q000737:chemistry; D013577:Syndrome
D009569:Nitric Oxide