Normal values of regional left ventricular endocardial motion: multicenter color kinesis study.
Our goal was to establish normal values for quantitative color kinesis indexes of left ventricular (LV) wall motion over a wide range of ages, which are required for objective diagnosis of regional systolic and diastolic dysfunction. Color-encoded images were obtained in 194 normal subjects (95 males, 99 females, age 2 mo to 79 yr) in four standard views. Quantitative indexes of magnitude and timing of systolic and diastolic function were studied for age- and gender-related differences. Normal limits of all ejection and filling indexes were in a narrow range (< or =25% of the mean), with no major gender-related differences. Despite invariable ejection fractions, both peak filling and ejection rates decreased with age (30 and 20%, correspondingly) with a concomitant increase in mean filling and ejection times, resulting in five- and twofold increases in the late to early filling and ejection ratios, correspondingly. Diastolic asynchrony increased with age (from 4.7 +/- 2.0 to 6.4 +/- 3.2 from the 2nd to 7th decade). The normal values of color kinesis indexes should allow objective detection of regional LV systolic and diastolic dysfunction.
Mor-Avi
V
V
The University of Chicago, Chicago, Illinois 60637, USA. vmoravi@medicine.bsd.uchicago.edu
Spencer
K
K
Gorcsan
J
J
Demaria
A
A
Kimball
T
T
Monaghan
M
M
Perez
J
J
Sun
J P
JP
Weinert
L
L
Bednarz
J
J
Collins
K
K
Edelman
K
K
Kwan
O L
OL
Glascock
B
B
Hancock
J
J
Baumann
C
C
Thomas
J
J
Lang
R
R
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003971:Diastole / Q000502:physiology; D018618:Echocardiography, Doppler, Color; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D015588:Observer Variation; D012016:Reference Values; D015203:Reproducibility of Results; D017678:Sex Distribution; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*