title: [Synthesis and properties of fluorescent labeled detergents analogues of glycocholic acid].
abstract: For studying membrane processes with participation of detergents, fluorescent analogues of glycocholic acid containing p-hydroxybenzyl, 7-nitrobenz-2-oxa-1,3-diazol-4-yl, or fluorescein-5-thiocarbamoyl fluorophore in the glycyl moiety attached to glycocholic acid were synthesized. The fluorophores are in the probes near their carboxyl groups and, in membrane systems, should therefore be situated on the interface and be sensitive to phase transitions. The critical micelle concentrations were determined for the analogues and found to be close to those of cholate and glycocholate in the case of the first two compounds. We presume that the behavior of the probes in membrane systems will mimic the behavior of the bile acid salts.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Grechishnikova
authors.forename: I D
authors.initials: ID
authors.lastname: Khaznaferova
authors.forename: S V
authors.initials: SV
authors.lastname: Kalinin
authors.forename: L I
authors.initials: LI
authors.lastname: Barsukov
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Molotkovskiĭ
mesh_terms: D003902:Detergents / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006000:Glycocholic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D008027:Light; D008823:Micelles; D012542:Scattering, Radiation; D013050:Spectrometry, Fluorescence
chemical_list: D003902:Detergents; D005456:Fluorescent Dyes; D008823:Micelles; D006000:Glycocholic Acid