title: Assessment of gastric electrical activity and autonomic function among diabetic and nondiabetic patients with symptoms of gastroesophageal reflux.
abstract: Gastroesophageal reflux disease (GERD) may present differently in patients with diabetes mellitus (DM) than in nondiabetics (NDM). We compared three tests in two patient groups with GERD symptoms: a DM group (n = 10) and a NDM group (n = 13). The tests were 24-hr esophageal pH, autonomic function testing (AFT), and electrogastrography (EGG). Analysis of the 23 patients revealed the DM group had normal 24-hr pH values (9 of 10 patients, mean pH 3.1 +/- 1.7), while NDM displayed abnormal pH values (9 of 13 patients, mean pH 21.2 +/- 5.9). AFT results were abnormal in DM (demonstrating cholinergic/ adrenergic dysfunction), but normal in NDM. EGG values were abnormal in both groups (mean 3.31 +/- 0.1 in each). We conclude that in GERD-symptomatic patients, those with DM frequently have normal 24-hr pH, but abnormal autonomic functioning, in contrast to NDM, who have abnormal 24-hr pH but normal autonomic function. Both groups had identically abnormal mean EGG values.
authors.affiliation: Department of Otolaryngology, University of Tennessee, Memphis 38163, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Jackson
authors.forename: H
authors.initials: H
authors.lastname: Rashed
authors.forename: S
authors.initials: S
authors.lastname: Cardoso
authors.forename: F
authors.initials: F
authors.lastname: Wong
authors.forename: R
authors.initials: R
authors.lastname: Werkman
authors.forename: J
authors.initials: J
authors.lastname: Thompson
authors.forename: T L
authors.initials: TL
authors.lastname: Abell
mesh_terms: D001341:Autonomic Nervous System / Q000503:physiopathology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology*; D004594:Electrophysiology; D004947:Esophagus / Q000378:metabolism; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000294:innervation / Q000503:physiopathology*