title: Mooren's ulcer in China: a study of clinical characteristics and treatment.
abstract: OBJECTIVE
  To investigate the clinical characteristics and compare the effects of several methods of treatment of Mooren's corneal ulcer.
  
  
  METHODS
  550 consecutive cases of Mooren's corneal ulcer were analysed in patients, including age, sex, laterality of eye, ulcer location, perforative rate, cure rate of surgeries, recurrent rate, the effects of conjunctiva excision, lamellar keratoplasty (LKP), and LKP plus 1% cyclosporin A eye drops.
  
  
  RESULTS
  The average age of onset was 48.4 years of age. The ratio of males to females was 1:0. 74. 165 (30%) cases had the disease bilaterally, of which 52 (31.5%) occurred in the young age group and 113 (68.5%) in the old age group. Ulcers of 501 eyes (70.1%) were located at the limbus of the palpebral fissure. The perforation rate was 13.3%, with perforation of 41 eyes (43.2%) occurring in the young age group and 54 (56.8%) in the old age group. Postoperative recurrence rate was 25.6%. The cure rate of the first procedure of LKP plus 1% cyclosporin A eye drops was 73.7%. The final cure rate was 95.6%, and the postoperative preservation rate of the eye globe was 99.7%.
  
  
  CONCLUSIONS
  This primary study provided the clinical characteristics of patients with Mooren's corneal ulcer in China. LKP plus 1% cyclosporin A eye drops was an effective treatment.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou, PR China. zoc@gzsums.edu.cn
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Xie
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Gong
authors.forename: Y
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002681:China / Q000453:epidemiology; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012422:Rupture, Spontaneous / Q000453:epidemiology; D018709:Statistics, Nonparametric
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine