[Experimental study of the effects of pituitary adenylate cyclase-activating polypeptide (PACAP) and its mechanism on the vascular cell components--the possible relationship between PACAP and atherosclerosis].
By using cultured vascular endothelial cell (EC) and smooth muscle cell (SMC) as model, the morphological and functional effects of PACAP on EC and SMC in normal and hyper-lipid culture circumstances as well as its possible mechanism of action were studied. The results showed that (1) PACAP may partly counteract the morphologic injury of EC and SMC produced by high lipid. (2) PACAP significantly increased the production of anti-AS substances by EC. (3) PACAP inhibited the proliferation of SMC. (4) PACAP reduced significantly the production of lipid peroxide by EC and SMC in hyperlipid circumstances. The present study suggests that PACAP has cytoprotective effect on EC and SMC and thus it is possible that PACAP has an anti-AS effects.
Chang
Q
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Department of Histology & Embryology, Sun Yat-sen University of Medical Science, Guangzhou.
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000187:drug effects; D001161:Arteriosclerosis / Q000517:prevention & control; D002455:Cell Division / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D009479:Neuropeptides / Q000494:pharmacology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011651:Pulmonary Artery / Q000166:cytology / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D014665:Vasodilator Agents