title: [Assessment of risk for the development of manifest atherosclerosis and indications for hypolipidemic therapy (global risk assessment)].
abstract: The estimated risk of development of complications of atherosclerosis (coronary or cerebral ischaemia) is one of the activities every physician should include in the diagnostic and therapeutic algorithm. Treatment with hypolipidaemic agents is indicated according to the European consensus if the danger of a coronary or cerebral event is 20%/10 years. The objective of preventive provisions should be reduction of this risk to < 5%/10 years in younger subjects (< 45 years in men and < 50 years in women) and < 10%/10 years in elderly subjects. These recommendations obviously do not apply to secondary prevention (in case of complications of atherosclerosis) where treatment with hypolipidaemic agents is indicated already when the LDL-cholesterol level is 2.3 mmol/l or when triacylglycerols are 2.3 mmol/l, combined with a drop of HDL-cholesterol to < 0.9 mmol/l.
authors.affiliation: Metabolická a diabetologická jednotka oddĕlení Nemocnice.
authors.forename: D
authors.initials: D
authors.lastname: Stejskal
authors.forename: R
authors.initials: R
authors.lastname: Pastorková
authors.forename: D
authors.initials: D
authors.lastname: Horalík
authors.forename: I
authors.initials: I
authors.lastname: Oral
mesh_terms: D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors