title: Delayed puberty associated with hyperprolactinemia caused by pituitary microadenoma.
abstract: Primary amenorrhea caused by the hyperprolactinemia is a rare condition characterized by the onset of thelarche and pubarche at appropriate ages but arrest of pubertal development before menarche. Hyperprolactinemia might be found in a few women with primary amenorrhea, yet relevant experience has apparently not been reported. We report a 16-year-old patient with hyperprolactinemia caused by a pituitary microadenoma. Her only symptom was delayed puberty without galactorrhea. Bromocriptine therapy was useful in order to induce the ovulation and cause the menarche.
authors.affiliation: Department of Obstetrics and Gynecology, Oita Medical University, Hasama-machi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawano
authors.forename: S
authors.initials: S
authors.lastname: Kamihigashi
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: I
authors.initials: I
authors.lastname: Miyakawa
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000175:diagnosis; D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D015519:Bone Density; D001971:Bromocriptine / Q000627:therapeutic use; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006727:Hormone Antagonists / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications*; D007986:Luteinizing Hormone / Q000097:blood; D008279:Magnetic Resonance Imaging; D008572:Menarche; D010060:Ovulation; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis; D011628:Puberty, Delayed / Q000188:drug therapy / Q000209:etiology*; D013972:Thyrotropin / Q000097:blood
chemical_list: D006727:Hormone Antagonists; D019382:Human Growth Hormone; D001971:Bromocriptine; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin