title: Histopathological and biochemical changes in the sutural region in craniosynostosis.
abstract: OBJECTIVE
  Histopathological observations and biochemical analysis of sutural bones in nine patients with craniosynostosis were compared with control subjects of the same age range.
  
  
  METHODS
  Microscopic examination in craniosynostosis showed formation of an active osseous front, with higher osteoblastic activity than in controls. Biochemical analysis revealed higher calcium, phosphorus, alkaline phosphatase, phospholipids and chondroitin sulphate-A contents in sutural bones of the same patients.
  
  
  CONCLUSIONS
  The present study systematically establishes a premature increase in osteogenesis in the sutures of craniosynostosis patients.
authors.affiliation: Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India. medinst@pgi.chd.nic.in
authors.forename: A
authors.initials: A
authors.lastname: Pathak
authors.forename: B K
authors.initials: BK
authors.lastname: Sandhu
authors.forename: B D
authors.initials: BD
authors.lastname: Radotra
authors.forename: N
authors.initials: N
authors.lastname: Khandelwal
authors.forename: R
authors.initials: R
authors.lastname: Nath
authors.forename: V K
authors.initials: VK
authors.lastname: Kak
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D002118:Calcium / Q000032:analysis; D002809:Chondroitin Sulfates / Q000032:analysis; D003398:Craniosynostoses / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010006:Osteoblasts / Q000737:chemistry / Q000473:pathology; D010012:Osteogenesis; D010743:Phospholipids / Q000032:analysis; D010758:Phosphorus / Q000032:analysis
chemical_list: D010743:Phospholipids; D010758:Phosphorus; D002809:Chondroitin Sulfates; D000469:Alkaline Phosphatase; D002118:Calcium