title: [Spatial structure of a Fab-fragment of a monoclonal antibody to human interleukin-2 in two crystalline forms at a resolution of 2.2 and 2.9 angstroms].
abstract: The three-dimensional structure of the antigen-binding fragment of a monoclonal antibody to human interleukin-2 was determined in two crystal forms by the X-ray method of molecular replacement at 2.2 and 2.9 A resolutions. The spatial structure of the protein and the stereochemistry of its antigen-binding site were analyzed.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Fokin
authors.forename: P V
authors.initials: PV
authors.lastname: Afonin
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Mikhaĭlova
authors.forename: I N
authors.initials: IN
authors.lastname: Tsygannik
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Mareeva
authors.forename: V A
authors.initials: VA
authors.lastname: Nesmeianov
authors.forename: W
authors.initials: W
authors.lastname: Pangborn
authors.forename: N
authors.initials: N
authors.lastname: Lee
authors.forename: W
authors.initials: W
authors.lastname: Duax
authors.forename: E
authors.initials: E
authors.lastname: Siszak
authors.forename: V Z
authors.initials: VZ
authors.lastname: Pletnev
mesh_terms: D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000737:chemistry* / Q000276:immunology; D000941:Antigens / Q000276:immunology; D001666:Binding Sites, Antibody; D018360:Crystallography, X-Ray; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry* / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology*; D008969:Molecular Sequence Data; D011487:Protein Conformation; D013237:Stereoisomerism
chemical_list: D000911:Antibodies, Monoclonal; D000941:Antigens; D007140:Immunoglobulin Fab Fragments; D007376:Interleukin-2