title: Hypertension associated with multiple renal arteries may be renin-dependent.
abstract: OBJECTIVE
  Subjects with multiple renal arteries have been shown to suffer more frequently from hypertension and to have higher blood pressures than subjects whose kidneys are supplied by single renal arteries. This study was carried out to determine whether subjects with multiple renal arteries also have higher renin activity.
  
  
  METHODS
  We studied 62 consecutive patients who had undergone angiography for various reasons. They were divided into two groups. Group A comprised 29 patients whose kidneys were supplied by single arteries (male :female ratio 1.63, mean age 51.8 +/- 1.9 years) while Group B comprised 33 patients with multiple renal arteries (male:female ratio 2, mean age 47.3 +/- 2.3 years).
  
  
  RESULTS
  Before stimulation with frusemide, the plasma renin in Group A was 0.79 +/- 0.13 ng angiotensin l/ml per h, while in Group B the corresponding figure was 1.73 +/- 0.38 ng angiotensin l/ml per h. This difference was statistically significant (P= 0.0127). Thirty minutes later the plasma renin level in Group A was 2.43 +/- 0.37 ng angiotensin l/ml per h versus a level of 3.86 +/- 0.53 ng angiotensin l/ml per h in Group B (P= 0.0169). Again, 30 minutes later the level was 2.59 +/- 0.4 ng angiotensin l/ ml per h in Group A, versus 3.79 +/- 0.59 ng angiotensin l/ ml per h in Group B (P= 0.0495).
  
  
  CONCLUSIONS
  We conclude that patients with multiple renal arteries constitute a group who have high plasma renin activity and may therefore be prone to develop arterial hypertension.
authors.affiliation: Institut für Pharmazeutische Biologie und Phytochemie, Westfälische Wilhelms-Universität Münster, Germany. glodnyb@uni-muenster.de
authors.forename: B
authors.initials: B
authors.lastname: Glodny
authors.forename: S
authors.initials: S
authors.lastname: Cromme
authors.forename: P
authors.initials: P
authors.lastname: Reimer
authors.forename: M
authors.initials: M
authors.lastname: Lennarz
authors.forename: G
authors.initials: G
authors.lastname: Winde
authors.forename: H
authors.initials: H
authors.lastname: Vetter
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure; D002216:Captopril / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012077:Renal Artery / Q000002:abnormalities*; D012083:Renin / Q000097:blood / Q000502:physiology*
chemical_list: D000450:Aldosterone; D005665:Furosemide; D002216:Captopril; D012083:Renin; D011188:Potassium