title: The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection.
abstract: To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected individuals (controls). H. pylori infection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; chi(2) = 13; P = 0.00032; P value corrected for multiple comparisons [Bonferroni correction] = 0. 00063).
authors.affiliation: Department of Molecular Human Genetics, Ruhr-University, 44780 Bochum, Germany. Erdmute.M.Kunstmann@rurh-uni-bochum.de
authors.forename: E
authors.initials: E
authors.lastname: Kunstmann
authors.forename: C
authors.initials: C
authors.lastname: Hardt
authors.forename: E
authors.initials: E
authors.lastname: Elitok
authors.forename: M
authors.initials: M
authors.lastname: Harder
authors.forename: S
authors.initials: S
authors.lastname: Suerbaum
authors.forename: U
authors.initials: U
authors.lastname: Peitz
authors.forename: W
authors.initials: W
authors.lastname: Schmiegel
authors.forename: J T
authors.initials: JT
authors.lastname: Epplen
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000209:etiology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta