title: Induction of GLUT-1 protein in adult human skeletal muscle fibers.
abstract: Prompted by our recent observations that GLUT-1 is expressed in fetal muscles, but not in adult muscle fibers, we decided to investigate whether GLUT-1 expression could be reactivated. We studied different stimuli concerning their ability to induce GLUT-1 expression in mature human skeletal muscle fibers. Metabolic stress (obesity, non-insulin-dependent diabetes mellitus), contractile activity (training), and conditions of de- and reinnervation (amyotrophic lateral sclerosis) could not induce GLUT-1 expression in human muscle fibers. However, regenerating muscle fibers in polymyositis expressed GLUT-1. In contrast to GLUT-1, GLUT-4 was expressed in all investigated muscle fibers. Although the significance of GLUT-1 in adult human muscle fibers appears limited, GLUT-1 may be of importance for the glucose supplies in immature and regenerating muscle.
authors.affiliation: Department of Pathology, Odense University Hospital, DK-5000 Odense, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Gaster
authors.forename: J
authors.initials: J
authors.lastname: Franch
authors.forename: P
authors.initials: P
authors.lastname: Staehr
authors.forename: H
authors.initials: H
authors.lastname: Beck-Nielsen
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: H D
authors.initials: HD
authors.lastname: Schrøder
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D015444:Exercise / Q000502:physiology; D005260:Female; D051272:Glucose Transporter Type 1; D051275:Glucose Transporter Type 4; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009004:Monosaccharide Transport Proteins / Q000032:analysis / Q000096:biosynthesis*; D009119:Muscle Contraction / Q000502:physiology; D018485:Muscle Fibers, Skeletal / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D009124:Muscle Proteins; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D009765:Obesity / Q000378:metabolism; D010807:Physical Endurance; D012038:Regeneration
chemical_list: D051272:Glucose Transporter Type 1; D051275:Glucose Transporter Type 4; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495677:SLC2A1 protein, human; C495692:SLC2A4 protein, human