Deletion of 3'-CBFB gene in association with an inversion (16)(p13q22) and a loss of the Y chromosome in a 2-year-Old child with acute myelogenous leukemia-M4.
Inversion 16(p13q22) is most commonly associated with acute myelomonocytic leukemia with abnormal eosinophils (M4). In association with this inversion, a proximal deletion at the 16p13 primary arm breakpoint occurs in 20% of cases. We report on a first case of inversion 16 with a distal deletion at the primary arm breakpoint 16q22, detected by using the fluorescent-labeled dual-color probe CBFB.
Batanian
J R
JR
Department of Pediatrics and Hematology/Oncology, Saint Louis University Pediatrics Research Institute, St. Louis, MO, USA.
Huang
Y
Y
Fallon
R
R
D002675:Child, Preschool; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D050658:Core Binding Factor beta Subunit; D004268:DNA-Binding Proteins / Q000235:genetics*; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics*
C493692:CBFB protein, human; D050658:Core Binding Factor beta Subunit; D004268:DNA-Binding Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors