No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease.
Recently a significant association of a missense mutation (Glu298Asp) of the endothelial nitric oxide synthase (NOS3) gene with late-onset Alzheimer's disease (LOAD) was reported. We tried to replicate this finding in a Japanese sample of 121 patients with LOAD, 51 with early-onset AD (EOAD), and 165 medical controls. However, the genotype and allelic distributions for the Glu298Asp polymorphism were similar for these three groups, suggesting that the Glu298Asp polymorphism of the NOS3 gene has no relevance to the development of AD in Japanese.
Kunugi
H
H
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan. hkunugi@med.teikyo-u.ac.jp
Akahane
A
A
Ueki
A
A
Otsuka
M
M
Isse
K
K
Hirasawa
H
H
Kato
N
N
Nabika
T
T
Kobayashi
S
S
Nanko
S
S
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics*; D001224:Aspartic Acid / Q000235:genetics; D002648:Child; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D018698:Glutamic Acid / Q000235:genetics; D006801:Humans; D007564:Japan; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D020641:Polymorphism, Single Nucleotide
D001224:Aspartic Acid; D018698:Glutamic Acid; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III