Experimental evidence of host specificity of Bartonella infection in rodents.
A large number of Bartonella species and genetic variants were compared for their ability to cause bacteremia in different rodent species: the cotton rat (Sigmodon hispidus), white-footed mouse (Peromyscus leucopus), BALB/c mouse and Wistar rat. Experimental data supported field observations that host specificity can occur among certain Bartonella species and rodent species. Bacteremia could only be readily produced in cotton rats or white-footed mice if the strains used for inoculation were originally obtained from the same species or from a phylogenetically close species. A few Bartonella colonies could be observed in the blood of some BALB/c mice by 7 days after inoculation, but no evidence of the persistence of the infection was found. Host specificity suggests the possibility of a long co-speciation of Bartonella species with their rodent hosts. Host-parasite relationships measured by the duration and level of bacteremia and the minimal infectious dose may serve as additional criteria for classification of Bartonella isolates obtained from natural environments.
Kosoy
M Y
MY
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA, USA. mck3@cdc.gov
Saito
E K
EK
Green
D
D
Marston
E L
EL
Jones
D C
DC
Childs
J E
JE
D000818:Animals; D016470:Bacteremia / Q000382:microbiology / Q000662:veterinary*; D001473:Bartonella / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D001474:Bartonella Infections / Q000097:blood / Q000382:microbiology / Q000662:veterinary*; D004269:DNA, Bacterial / Q000737:chemistry / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C / Q000382:microbiology; D010542:Peromyscus / Q000382:microbiology; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D051381:Rats; D017208:Rats, Wistar / Q000382:microbiology; D012376:Rodent Diseases / Q000097:blood / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D016205:Sigmodontinae / Q000382:microbiology; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms
D004269:DNA, Bacterial