Protegrins: new antibiotics of mammalian origin.
Protegrins and their derivatives are a new class of peptide antibiotics based on mammalian antimicrobial peptides. Their pharmacological properties include an unusually broad spectrum of antimicrobial activity against Gram-positive and Gram-negative bacteria, fungi and some enveloped viruses. Preclinical and clinical studies of the lead compound, IB-367, developed for topical applications, show promise for the prevention of chemotherapy- and radiation-induced oral mucositis.
Bellm
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CHS 37-055, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA.
Lehrer
R I
RI
Ganz
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T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D006801:Humans; D008322:Mammals / Q000378:metabolism*; D010455:Peptides
D000900:Anti-Bacterial Agents; D010455:Peptides