Kinetic model for 5-fluorouridine degradation. Catalytic effect of 5-fluorouracil.
The effects of 5-fluorouridine (5-FUR, CAS 316-46-1) degradation products, 5-fluorouracil (5-FU, CAS 51-21-8) and D-ribose (CAS 50-69-1), on its degradation rate was investigated following a 2(3) factorial design. The experimental data fitted to the proposed mathematical model which includes two parallel degradation mechanisms: the first one, a second order bimolecular reaction involving both 5-FUR and 5-FU, and the second, a first order one. Experimental data obtained show a high variability. Both graphic and statistical analysis of the experiments for which a full kinetic model was applied manifested that the degradation mechanism included an autocatalytic route and confirmed the role of the 5-FU on the hydrolysis of 5-FUR.
Dorta
M J
MJ
Departamento Ingeniería Química y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
Munguía
O
O
Llabrés
M
M
D000465:Algorithms; D002384:Catalysis; D005472:Fluorouracil / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D008956:Models, Chemical; D014529:Uridine / Q000031:analogs & derivatives* / Q000737:chemistry
C001943:5-fluorouridine; D005472:Fluorouracil; D014529:Uridine