The role of mucins in host-parasite interactions. Part I-protozoan parasites.
Parasite-derived mucin-like molecules might be involved in parasite attachment to and invasion of host cells. In addition, parasites might secrete mucin-degrading enzymes, enabling the penetration of protective mucus gels that overlie the mucosal surfaces of their potential hosts. Furthermore, they might generate binding ligands on the membrane-bound mucins of host cells by using specific glycosidases. It is possible that host mucins and mucin-like molecules prevent the establishment of parasites or facilitate parasite expulsion. They might also serve as a source of metabolic energy and adhesion ligands for those parasites adapted to exploit them. Sally Hicks and colleagues here review the biochemical properties of mucins and mucin-like molecules in relation to interactions (established and putative) between protozoan parasites and their hosts.
Hicks
S J
SJ
Centre for Biomedical Sciences, School of Applied Sciences, University of Wales Institute Cardiff, Cardiff, UK. shicks@uwic.ac.uk
Theodoropoulos
G
G
Carrington
S D
SD
Corfield
A P
AP
D000818:Animals; D056890:Eukaryota / Q000502:physiology*; D006790:Host-Parasite Interactions / Q000502:physiology*; D009077:Mucins / Q000502:physiology*
D009077:Mucins