title: Progesterone receptor activation. an alternative to SERMs in breast cancer.
abstract: Data regarding the effects of progesterone and a progestagen on human normal breast epithelial cell proliferation and apoptosis are presented here. In postmenopausal women, adding progesterone to percutaneously administrated oestradiol significantly reduces the proliferation induced by oestradiol. In vitro and in premenopausal women, stopping the administration of nomegestrol acetate triggers a peak of apoptosis. Fibro-adenoma and cancerous cells do not show this regulation of apoptosis. Progesterone seems to be important in normal breast homeostasis.
authors.affiliation: Laboratory of Tumor and Development Biology, Tour de Pathologie +3 (B23), Sart-Tilman, B4000, Liège, Belgique. joelle.desreux@chu.ulg.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Desreux
authors.forename: F
authors.initials: F
authors.lastname: Kebers
authors.forename: A
authors.initials: A
authors.lastname: Noël
authors.forename: D
authors.initials: D
authors.lastname: Francart
authors.forename: H
authors.initials: H
authors.lastname: Van Cauwenberge
authors.forename: V
authors.initials: V
authors.lastname: Heinen
authors.forename: J L
authors.initials: JL
authors.lastname: Thomas
authors.forename: A M
authors.initials: AM
authors.lastname: Bernard
authors.forename: J
authors.initials: J
authors.lastname: Paris
authors.forename: R
authors.initials: R
authors.lastname: Delansorne
authors.forename: J M
authors.initials: JM
authors.lastname: Foidart
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006801:Humans; D011980:Receptors, Progesterone / Q000378:metabolism / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*
chemical_list: D011980:Receptors, Progesterone; D020845:Selective Estrogen Receptor Modulators