[Ineffective platelet transfusion in patients with hematology malignancy].
OBJECTIVE
To explore the relationship between the effects of platelet transfusion and histocompatibility antigen (HLA).


METHODS
The relationship between the corrected count increment (CCI) of platelet with lymphocytotoxicity test (LCT) and human histocompatibity antigen system-I subtype (HLA-I) in 126 hospitalized patients who accepted platelet transfusion.


RESULTS
Ineffective platelet transfusion was strongly related to LCT positive and LCT intensity (P < 0.01). The HLA A2 gene frequency was 0.91. The frequency was much higher than that of health human being (0.54).


CONCLUSIONS
Positive LCT was mainly immune factor for ineffective platelet transfusion. CCI and LCT should be the routine test for platelet patients. It may improve the effects of platelet transfusion.
Chen
S
S
Department of Hematology, Guangdong Provincial People's Hospital, Guangzhou.
Xiao
L
L
Zou
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000276:immunology* / Q000628:therapy; D000961:Antilymphocyte Serum; D005260:Female; D015234:HLA-A Antigens / Q000097:blood*; D006801:Humans; D007938:Leukemia / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion
D000961:Antilymphocyte Serum; D015234:HLA-A Antigens