Abnormal synaptic organization between granule cells and Purkinje cells in the new ataxic mutant mouse, pogo.
The pogo mouse is a new ataxic mutant derived from the Korean wild mouse. The pathological manifestations include difficulty in maintaining normal posture and the inability to walk straight. The ataxia becomes apparent at about 2 weeks of age. Electron microscopic studies of the pogo/pogo homozygous cerebellum, revealed that the ectopic spines emanating from the primary dendrite of Purkinje cells were observed. Major difference between pogo/pogo homozygous and non-affected pogo/+ heterozygous was the synaptic organization of the molecular layer. Parallel fiber varicosities were larger than normal and a single fiber often established synaptic contacts with up to four dendritic spines of a Purkinje cell. This correlation between the presence of altered synaptic organization in the cerebellum and ataxia in pogo/pogo mutant mice warrants further investigation.
Jeong
Y G
YG
Department of Anatomy, College of Medicine, Konyang University, Nonsan, 320-711, Chungnam, South Korea. ygjeong@kytis.konyang.ac.kr
Hyun
B H
BH
D000818:Animals; D001259:Ataxia / Q000235:genetics / Q000473:pathology*; D064026:Calbindins; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D003712:Dendrites / Q000473:pathology / Q000648:ultrastructure; D006579:Heterozygote; D006720:Homozygote; D007150:Immunohistochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D008818:Mice, Neurologic Mutants; D008854:Microscopy, Electron; D010641:Phenotype; D011689:Purkinje Cells / Q000473:pathology* / Q000648:ultrastructure; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D013569:Synapses / Q000473:pathology* / Q000648:ultrastructure
D064026:Calbindins; D064030:S100 Calcium Binding Protein G