title: Cerebellar cortical degeneration disrupts discrimination learning but not delay or trace classical eyeblink conditioning.
abstract: The authors investigated classical eyeblink conditioning in a relatively rare patient, B.R., with extensive cerebellar cortical atrophy and marked sparing of the dentate nucleus. Patient B.R.'s ability to acquire and extinguish simple associations (delay and trace conditioning tasks) as well as her ability to acquire more complex associations (temporal and simple discrimination tasks) were examined. There are 2 primary findings from this study. First, B.R. showed normal acquisition and extinction in delay and trace conditioning. Second, she demonstrated a complete inability to learn associative discriminations, even in the case of a simple 2-tone discrimination within the context of a delay paradigm. The latter finding was unexpected because of the sparing of her deep cerebellar nuclei. These data suggest that the cerebellar cortex, or pathways traversing cerebellar cortex, play an important role in classical eyeblink discrimination learning.
authors.affiliation: Memory Disorders Research Center, Boston University School of Medicine and Veterans Affairs Boston Healthcare System, Massachusetts 02130, USA. cbrawn@bu.edu
authors.forename: C B
authors.initials: CB
authors.lastname: Fortier
authors.forename: J F
authors.initials: JF
authors.lastname: Disterhoft
authors.forename: R
authors.initials: R
authors.lastname: McGlinchey-Berroth
mesh_terms: D000328:Adult; D001767:Blinking / Q000502:physiology*; D002526:Cerebellar Diseases / Q000473:pathology* / Q000503:physiopathology*; D003214:Conditioning, Classical / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology*; D005108:Extinction, Psychological; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D012054:Reinforcement, Psychology; D013997:Time Factors