title: Association of human papillomavirus type 6 with a verruciform xanthoma.
abstract: We report a case of verruciform xanthoma (VX) associated with human papillomavirus (HPV) in a 67-year-old male. The patient had a pale-reddish, granular and verrucous tumor on the right side of his scrotum for four years. Histopathologic examination showed typical features of VX. HPV was detected by immunohistochemistry, electron microscopy, and PCR examinations. Ultrastructural examination revealed virus-like particles of 40-50 nm in the nucleus of the upper epidermal keratinocytes. HPV type 6a DNA was detected in lesional tissue by polymerase chain reaction and sequence analysis. To the best of our knowledge, this is the first case report of VX associated with HPV.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan. khaskhelis@hotmail.com
authors.forename: N M
authors.initials: NM
authors.lastname: Khaskhely
authors.forename: H
authors.initials: H
authors.lastname: Uezato
authors.forename: T
authors.initials: T
authors.lastname: Kamiyama
authors.forename: M
authors.initials: M
authors.lastname: Maruno
authors.forename: K I
authors.initials: KI
authors.lastname: Kariya
authors.forename: M
authors.initials: M
authors.lastname: Oshiro
authors.forename: S
authors.initials: S
authors.lastname: Nonaka
mesh_terms: D000368:Aged; D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification* / Q000648:ultrastructure; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D013733:Testicular Diseases / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*; D014973:Xanthomatosis / Q000473:pathology / Q000821:virology*
chemical_list: D004279:DNA, Viral