Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.
Receptor-activated phosphoinositide (PI) 3-kinases produce PtdIns(3, 4,5)P(3) and its metabolite PtdIns(3,4)P(2) that function as second messengers in membrane recruitment and activation of target proteins. The cytohesin and centaurin protein families are potential targets for PtdIns(3,4,5)P(3) that also regulate and interact with Arf GTPases. Consequently, these families are poised to transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. Proposed downstream events in PI 3-kinase-regulated Arf cascades include modulation of vesicular trafficking and the actin cytoskeleton.
Jackson
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Dept of Haematology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, NW3 2PF, London, UK. t.jackson@rfc.ucl.ac.uk
Kearns
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BG
Theibert
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AB
D020823:ADP-Ribosylation Factor 1 / Q000378:metabolism*; D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D015398:Signal Transduction
C100956:ADAP1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D020662:Guanine Nucleotide Exchange Factors; D009419:Nerve Tissue Proteins; D018129:Phosphatidylinositol Phosphates; C100723:cytohesin-1; D019869:Phosphatidylinositol 3-Kinases; D020823:ADP-Ribosylation Factor 1