[Advancement on neurotransmitter transporters].
The neurotransmitter transporter (NTT), a kind of glycoprotein situating on the presynaptic membrane, glial membrane, or vesicle membrane, has become the focusing point of neuroscience research in recent years. They could combine selectively with transmitters released into synaptic cleft and carry them back into cells to aid the termination of synaptic transmission. In this way, NTT took an important part in modulation of information between neurons. Study on NTT has not been reported domestically. This article reviewed recent studies on molecular structure, classification, study methods, distribution, function, modulating factors and gene modulation, focus of study and also unresolved problems of NTT.
Gao
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Institute of Neurosciences, Fourth Military Medical University, Xi'an.
Rao
Z R
ZR
D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000096:biosynthesis / Q000502:physiology*; D027342:Excitatory Amino Acid Transporter 2; D006801:Humans; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000096:biosynthesis / Q000502:physiology*
D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D027342:Excitatory Amino Acid Transporter 2; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017981:Receptors, Neurotransmitter