title: A controlled study of nortriptyline in children and adolescents with attention deficit hyperactivity disorder.
abstract: OBJECTIVE
  To study the efficacy and tolerability of nortriptyline (NT) in the treatment of pediatric attention deficit hyperactivity disorder (ADHD).
  
  
  METHODS
  Subjects were outpatient children and adolescents with ADHD ascertained from clinical referrals. Subjects were enrolled in a 6-week open study in which NT was titrated to 2 mg/kg/day as tolerated over 2 weeks. Using either a 30 % reduction in the ADHD rating scale or a score of 1 or 2 on the Clinical Global Impression (CGI) scale for ADHD improvement, responders to treatment were then randomized into a 3-week, controlled discontinuation phase. During this phase, subjects either continued on their current dose of NT or were tapered to placebo under double-blind conditions. Subjects were monitored for symptoms of ADHD, oppositionality, anxiety, and depression.
  
  
  RESULTS
  Of the 35 subjects enrolled in the study, 32 completed the open phase and 23 completed the discontinuation phase. The mean dose of NT was 80 mg (1.8 mg/kg/day), resulting in a serum level of 81 ng/ml. At the conclusion of the open 6-week study, NT was related to a significant reduction in ADHD (p < 0.001) and oppositional symptoms (p < 0.001). At the conclusion of the discontinuation phase, the 12 subjects randomized to NT had significantly lower scores on the DSM-IV ADHD symptom checklist than those 11 subjects randomized to placebo (31 versus 21; t = 2.2; p < 0.04). No significant adverse events were observed, and children were noted to have weight gain during the trial.
  
  
  CONCLUSIONS
  These data suggest that NT is effective in reducing symptoms not only of ADHD but also of oppositionality. This group of children and adolescents tolerated robust dosing of NT well, with few clinical or cardiovascular adverse events.
authors.affiliation: Consolidated Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Prince
authors.forename: T E
authors.initials: TE
authors.lastname: Wilens
authors.forename: J
authors.initials: J
authors.lastname: Biederman
authors.forename: T J
authors.initials: TJ
authors.lastname: Spencer
authors.forename: R
authors.initials: R
authors.lastname: Millstein
authors.forename: D A
authors.initials: DA
authors.lastname: Polisner
authors.forename: J Q
authors.initials: JQ
authors.lastname: Bostic
mesh_terms: D000293:Adolescent; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009661:Nortriptyline / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D009661:Nortriptyline