title: Pharmacokinetics of intravenously administered digoxin and histopathological picture in rabbits with experimental bile duct obstruction.
abstract: This study aimed to examine the effect of obstructive cholestasis on the pharmacokinetics of digoxin. Eighteen male rabbits were randomly ascribed to the two study groups: the sham-operated control group and the examined group - with common and cystic bile duct ligations. Digoxin was administered intravenously as a single dose of 0.02 mg/kg, and blood samples were withdrawn for up to 24 h. Digoxin concentrations were determined by the FPIA method. The pharmacokinetic parameters were calculated using a noncompartmental analysis. During the whole observation period the blood serum concentrations of digoxin were statistically higher in animals with obstructive cholestasis versus the controls. A significant increase in the area under the plasma concentration-time curve, decrease in the total body clearance and in the volume of distribution on the 6th day after the bile ducts ligation as compared to the sham-operated controls, were observed. The obtained results suggest an impaired elimination of digoxin in obstructive cholestasis in rabbits.
authors.affiliation: Department of General and Transplantation Surgery, Pomeranian Academy of Medicine, 70-111, Szczecin, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Wójcicki
authors.forename: M
authors.initials: M
authors.lastname: Drozdzik
authors.forename: T
authors.initials: T
authors.lastname: Sulikowski
authors.forename: J
authors.initials: J
authors.lastname: Wójcicki
authors.forename: B
authors.initials: B
authors.lastname: Gawrońska-Szklarz
authors.forename: S
authors.initials: S
authors.lastname: Zieliński
authors.forename: L
authors.initials: L
authors.lastname: Rózewicka
mesh_terms: D000818:Animals; D019540:Area Under Curve; D002779:Cholestasis / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008657:Metabolic Clearance Rate; D011817:Rabbits
chemical_list: D004077:Digoxin