One-month safety study of intraperitoneal VRCTC-310-Onco (crotoxin + cardiotoxin) in rats.
To evaluate the toxicity of VRCTC-310-Onco (Crotalus durissus terrificus crotoxin + cardiotoxin from Naja naja atra), 10 Sprague-Dawley rats were implanted with intraperitoneal slow-release devices and subjected to treatment with 0.5 microgram/g body weight/d for 14 days. Biochemical evidence at days 7 and 14 showed blood, muscular, renal and metabolic disturbance, mostly reversed by day 28. No significant changes were found in necropsy. The limited toxicity of i.p. VRCTC-310-Onco in rats deserves further study.
Stanchi
N O
NO
Cátedra de Microbiologia, Facultad de Ciencias Veterinarias (UNLP), Argentina.
Arias
D
D
Bartolucci
E
E
Martino
P E
PE
Gimeno
E J
EJ
Diez
R A
RA
Costa
L A
LA
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004179:Cobra Cardiotoxin Proteins / Q000008:administration & dosage / Q000633:toxicity*; D003439:Crotoxin / Q000008:administration & dosage / Q000633:toxicity*; D004338:Drug Combinations; D004435:Eating / Q000502:physiology; D004912:Erythrocytes / Q000187:drug effects; D015918:Infusion Pumps, Implantable; D007274:Injections, Intraperitoneal; D007962:Leukocytes / Q000187:drug effects; D008099:Liver / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood; D014882:Water-Electrolyte Balance / Q000502:physiology
D000970:Antineoplastic Agents; D004179:Cobra Cardiotoxin Proteins; D004338:Drug Combinations; D014280:Triglycerides; C084936:cardiotoxin, crotoxin drug combination; D003439:Crotoxin; D002784:Cholesterol