Macrophages and HIV-1-associated dementia.
One of the strongest predictors for HIV-1-associated dementia is the presence of monocytic infiltration in perivascular areas of the brain. Therefore, macrophages have been suggested to play a major role in the development of this disease. This review focuses on possible mechanisms through which the macrophage may enhance disease progression by mediating neuronal damage.
Boven
L A
LA
Department of Clinical Neurosciences, University of Calgary, AB, Canada. laboven@yahoo.com
D015526:AIDS Dementia Complex / Q000209:etiology*; D001253:Astrocytes; D001812:Blood-Brain Barrier; D015497:HIV-1; D006801:Humans; D008264:Macrophages; D019636:Neurodegenerative Diseases / Q000209:etiology*; D009498:Neurotoxins / Q000633:toxicity; D012191:Retroviridae Proteins / Q000633:toxicity
D009498:Neurotoxins; D012191:Retroviridae Proteins