Response to tissue injury.
Cutaneous injury, whether by laser, chemical, or scalpel, results in scar formation. The normal response to such an insult occurs in the middle of a continuum of wound repair processes. On one end of the continuum are the overhealed responses (i.e., keloids). On the opposite end are tissue regeneration and scarless healing as seen in fetal wounds. This article reviews the molecular biology and mechanisms leading to these various clinical phenotypes and discusses future potential modalities that may replicate the scarless wound healing mechanism in adults.
Peled
Z M
ZM
Laboratory of Developmental Biology and Repair, New York, New York, USA.
Chin
G S
GS
Liu
W
W
Galliano
R
R
Longaker
M T
MT
D000328:Adult; D000818:Animals; D017439:Cicatrix, Hypertrophic / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control; D016207:Cytokines / Q000502:physiology; D005314:Embryonic and Fetal Development; D006801:Humans; D007627:Keloid / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D017695:Soft Tissue Injuries / Q000503:physiopathology*; D015291:Transforming Growth Factors / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D016207:Cytokines; D015291:Transforming Growth Factors