Thyroid hormone of maternal origin regulates the expression of RC3/neurogranin mRNA in the fetal rat brain.
Recent clinical studies indicate that thyroid hormone plays essential roles in fetal brain development. However, the mechanism by which thyroid hormone affects fetal brain development is poorly studied. We recently identified several genes expressed in the fetal cortex whose abundance is affected by thyroid hormone of maternal origin. However, it is unclear whether these genes are directly regulated by thyroid hormone. Because these are the first genes known to be regulated by thyroid hormone during fetal development, we sought to expand our investigation to genes known to be regulated directly by thyroid hormone. We now report that the well-known thyroid hormone-responsive gene RC3/neurogranin is expressed in the fetal brain and is regulated by thyroid hormone of maternal origin. These findings support the concept that maternal thyroid hormone exerts a direct action on the expression of genes in the fetal brain that are important for normal neurological development.
Dowling
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AL
Biology Department and Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA.
Zoeller
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RT
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology; D001921:Brain / Q000196:embryology*; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D002540:Cerebral Cortex / Q000196:embryology; D005314:Embryonic and Fetal Development; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D005865:Gestational Age; D007093:Imidazoles / Q000494:pharmacology; D008431:Maternal-Fetal Exchange; D009419:Nerve Tissue Proteins / Q000235:genetics*; D051579:Neurogranin; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013963:Thyroid Hormones / Q000502:physiology*; D013974:Thyroxine / Q000494:pharmacology
C107674:2-mercapto-1-methylimidazole; D013956:Antithyroid Agents; D002148:Calmodulin-Binding Proteins; D007093:Imidazoles; D009419:Nerve Tissue Proteins; C496651:Nrgn protein, rat; D013963:Thyroid Hormones; D051579:Neurogranin; D013974:Thyroxine