[Family study of patients with aspirin intolerance and rhinosinusitis].
The high prevalence of aspirin intolerance in asthmatics and patients with nasal polyps as well as reports of familial clustering suggest a genetic disposition of this disease. Our study aimed at obtaining further evidence of hereditary factors in this disease. We included 33 unselected patients from 28 families with aspirin intolerance and rhinosinusitis in this study. Controls were recruited from individuals treated in our ENT clinic for diseases other than aspirin intolerance (n = 52). A questionnaire focused on family histories as well as reports on diseases of the upper respiratory tract or allergies. ASS intolerance was verified either by bronchial or nasal provocation tests. We found cases of aspirin intolerance among parents, siblings, and children of ASS intolerant probands. The children of probands had nasal polyps and rhinosinusitis more often than the children of controls. We propose that ASS intolerance with nasal polyps and asthma represents a complex phenotype, with genetic and environmental factors contributing to its manifestation.
May
A
A
Hals-Nasen-Ohren-Klinik, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.
Wagner
D
D
Langenbeck
U
U
Weber
A
A
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced / Q000235:genetics; D001985:Bronchial Provocation Tests; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000139:chemically induced* / Q000235:genetics; D009299:Nasal Provocation Tests; D010641:Phenotype; D012130:Respiratory Hypersensitivity / Q000139:chemically induced / Q000235:genetics; D012220:Rhinitis / Q000139:chemically induced* / Q000235:genetics; D012852:Sinusitis / Q000139:chemically induced* / Q000235:genetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin