title: Cortical evoked potentials of the dorsal nerve of the clitoris and female sexual dysfunction in multiple sclerosis.
abstract: OBJECTIVE
  We evaluated whether disrupting genital central nervous system pathways is associated with subjective reports of sexual dysfunction in women with multiple sclerosis.
  
  
  METHODS
  We performed pudendal somatosensory evoked potential testing in and had sexual questionnaires completed by 14 women with a mean age of 47 years who had multiple sclerosis.
  
  
  RESULTS
  The mean expanded disability status score was 5. All but 1 woman reported the desire for sexual intercourse. There was a high rate of dissatisfaction with their sex life and all study participants had concomitant bladder and bowel function problems. The most common sexual complaint was difficult or no orgasm, which was statistically associated with abnormalities or absence of 1 or both pudendal cortical evoked potentials. Fatigue and arousal disorders were also common.
  
  
  CONCLUSIONS
  Women with multiple sclerosis have a high self-reported rate of sexual dysfunction, which decreases quality of life. Electrodiagnostic data imply that pudendal somatosensory innervation is necessary for normal female orgasmic function. More study is needed to confirm these findings.
authors.affiliation: Department of Urology, University of Washington, Seattle, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Yang
authors.forename: J R
authors.initials: JR
authors.lastname: Bowen
authors.forename: G H
authors.initials: GH
authors.lastname: Kraft
authors.forename: E M
authors.initials: EM
authors.lastname: Uchio
authors.forename: B G
authors.initials: BG
authors.lastname: Kromm
mesh_terms: D000328:Adult; D002987:Clitoris / Q000294:innervation*; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications*; D012735:Sexual Dysfunction, Physiological / Q000150:complications / Q000175:diagnosis*; D020018:Sexual Dysfunctions, Psychological / Q000150:complications / Q000175:diagnosis*