Evaluation of antitussive potential of Jussiaea suffruticosa linn. extract in albino mice.
The antitussive activity of a methanol extract of Jussiaea suffruticosa Linn. (MEJS) (family Onagraceae) leaves has been evaluated for its potential on a cough induced by sulphur dioxide (SO(2)) gas model in mice. The extract (MEJS) showed significant antitussive activity in a dose dependent manner. The antitussive potential of MEJS was comparable to that of codeine phosphate (10 mg/kg), a standard drug. The extract (MEJS) at a dose level of 200 and 400 mg/kg, p.o. showed appreciable inhibition on the cough reflex by 48.52% and 59.8% respectively during 120 min of the experiment.
Murugesan
T
T
Department of Pharmaceutical Technology, Jadavpur University, Calcutta - 700 032, India.
Ghosh
L
L
Mukherjee
P K
PK
Pal
M
M
Saha
B P
BP
D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003371:Cough / Q000517:prevention & control*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007194:India; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D019685:Rosales; D013458:Sulfur Dioxide
D000996:Antitussive Agents; D010936:Plant Extracts; D013458:Sulfur Dioxide