Antibody regulation of B cell development.
Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control a series of antigen-independent checkpoints during B cell development. These physiologic processes are regulated by a complex of membrane immunoglobulin and two signal transducing proteins known as Ig alpha and Ig beta. Here we focus on the role of antibodies in governing the maturation of B cells from early antigen-independent through the final antigen-dependent stages.
Meffre
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Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA.
Casellas
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Nussenzweig
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MC
D000483:Alleles; D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D017637:Clonal Deletion; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D011971:Receptors, Immunologic / Q000235:genetics; D012641:Selection, Genetic; D015398:Signal Transduction
D000906:Antibodies; D007143:Immunoglobulin Heavy Chains; D011971:Receptors, Immunologic