Hepatitis E virus infection in chimpanzees: a retrospective analysis.
Different patterns of disease were observed among 11 chimpanzees who were inoculated intravenously with hepatitis E virus (HEV) positive fecal specimens from four different outbreaks (Nepal 1981, Uzbekistan 1981, Pakistan 1985, and Mexico 1986). Five chimpanzees had marginal or no liver enzyme elevations within 70 days of inoculation. Two of the chimpanzees had limited viremia, but did not produce detectable antibody. The four remaining chimpanzees had liver enzyme elevations, viral shedding, viremia, seroconversion to anti-HEV, and detectable HEV antigen in liver biopsy specimens. These results may reflect the range of infection patterns that develop in humans after natural exposure to the HEV.
McCaustland
K A
KA
Hepatitis Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30033, USA.
Krawczynski
K
K
Ebert
J W
JW
Balayan
M S
MS
Andjaparidze
A G
AG
Spelbring
J E
JE
Cook
E H
EH
Humphrey
C
C
Yarbough
P O
PO
Favorov
M O
MO
Carson
D
D
Bradley
D W
DW
Robertson
B H
BH
D000818:Animals; D018420:Ape Diseases / Q000097:blood / Q000503:physiopathology / Q000821:virology*; D004195:Disease Models, Animal; D006508:Hepatitis Antibodies / Q000097:blood; D018963:Hepatitis Antigens / Q000032:analysis; D016751:Hepatitis E / Q000662:veterinary*; D016752:Hepatitis E virus / Q000276:immunology / Q000302:isolation & purification*; D008099:Liver / Q000503:physiopathology / Q000821:virology; D002679:Pan troglodytes; D012189:Retrospective Studies; D014766:Viremia / Q000821:virology
D006508:Hepatitis Antibodies; D018963:Hepatitis Antigens