Recurrent laryngeal nerve transposition in guinea pigs.
Improved control of prosthetic voice aids for laryngectomees might be possible to obtain with residual laryngeal motor nerve signals. We were able to recover motor signals from the recurrent laryngeal nerve (RLN) by transposing it into the ipsilateral denervated sternohyoid muscle (SH) in 8 guinea pigs. Reinnervation was monitored by electromyographic recordings from surface and intramuscular needle electrodes in awake animals. Within 4 to 14 weeks after surgery, all animals demonstrated laryngeal-like motor activity in the reinnervated SH, including activity during respiration, sniffing, swallowing, and/or vocalizing. After 3 to 6 months, the animals were reanesthetized, and nerve stimulation and section experiments confirmed the RLN as the source of reinnervation in all cases. In several animals, activity of the RLN-innervated SH was demonstrated to be correlated with that of contralateral laryngeal muscles. Histochemical analysis of the SH indicated a unilateral transformation from mostly fatigable to mostly fatigue-resistant fiber types ipsilateral to the RLN transposition, a phenotype more typical of laryngeal muscles. Thus, RLN transposition at the time of laryngectomy may be a method for salvaging laryngeal control signals that could be used to control prosthetic voice devices.
Heaton
J T
JT
Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA.
Kobler
J B
JB
Goldstein
E A
EA
McMahon
T A
TA
Barry
D T
DT
Hillman
R E
RE
D000714:Anastomosis, Surgical; D000818:Animals; D004576:Electromyography; D006168:Guinea Pigs; D007821:Laryngeal Muscles / Q000294:innervation*; D008866:Microsurgery; D009046:Motor Neurons / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D016067:Nerve Transfer / Q000379:methods*; D012009:Recurrent Laryngeal Nerve / Q000601:surgery*; D013071:Speech, Alaryngeal