Dose response of laboratory markers to alcohol consumption in a general population.
The dose response to alcohol use of carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and their combination (gamma-CDT) was studied in an age- and gender-stratified, random sample from Finland in 1997. A linear association with a threshold between alcohol consumption and the three markers was observed. Body mass index was negatively associated with CDT and positively with GGT Age was positively associated with GGT and gamma-CDT In conclusion, CDT appears to be an early phase marker of alcohol consumption. The combined marker, gamma-CDT, was less associated with factors such as body mass index but more strongly correlated with alcohol consumption than were the two markers separately.
Sillanaukee
P
P
Alcohol-related Diseases, Pharmacia & Upjohn Diagnostics AB, Uppsala, Sweden. Pekka.Sillanaukee@finnish-immunotech.com
Massot
N
N
Jousilahti
P
P
Vartiainen
E
E
Sundvall
J
J
Olsson
U
U
Poikolainen
K
K
Pönniö
M
M
Allen
J P
JP
Alho
H
H
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000378:metabolism*; D015415:Biomarkers; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D012907:Smoking; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000097:blood*
D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; D005723:gamma-Glutamyltransferase