Is overt stuttered speech a prerequisite for the neural activations associated with chronic developmental stuttering?
Four adult right-handed chronic stutterers and four age-matched controls completed H(2)(15)O PET scans involving overt and imagined oral reading tasks. During overt stuttered speech prominent activations occurred in SMA (medial), BA 46 (right), anterior insula (bilateral), and cerebellum (bilateral) plus deactivations in right A2 (BA 21/22). These activations and deactivations also occurred when the same stutterers imagined they were stuttering. Some parietal regions were significantly activated during imagined stuttering, but not during overt stuttering. Most regional activations changed in the same direction when overt stuttering ceased (during chorus reading) and when subjects imagined that they were not stuttering (also during chorus reading). Controls displayed fewer similarities between regional activations and deactivations during actual and imagined oral reading. Thus overt stuttering appears not to be a prerequisite for the prominent regional activations and deactivations associated with stuttering.
Ingham
R J
RJ
University of California, Santa Barbara 93106, USA. rjingham@humanitas.ucsb.edu
Fox
P T
PT
Costello Ingham
J
J
Zamarripa
F
F
D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism / Q000503:physiopathology*; D002531:Cerebellum / Q000378:metabolism / Q000503:physiopathology; D002908:Chronic Disease; D002658:Developmental Disabilities / Q000503:physiopathology*; D005625:Frontal Lobe / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D010296:Parietal Lobe / Q000378:metabolism / Q000503:physiopathology; D013342:Stuttering / Q000175:diagnosis / Q000503:physiopathology*; D013702:Temporal Lobe / Q000378:metabolism / Q000503:physiopathology; D014055:Tomography, Emission-Computed