title: Dynamic thermodynamic resolution: control of enantioselectivity through diastereomeric equilibration.
abstract: A theoretical foundation, tools for recognition and control, and recent examples of a class of asymmetric transformation termed dynamic thermodynamic resolution are presented. Enantioselective reaction pathways that involve an induced diastereomeric equilibration to intermediates, which are configurationally stable on the time scale of a subsequent reaction, are illustrated. Dynamic thermodynamic resolution differs from the classic, well-documented pathways of kinetic resolution and dynamic kinetic resolution in that equilibration and resolution can be operative on one system in separate controllable steps. This approach offers a high level of flexibility and provides multiple opportunities for optimization of enantioselectivity.
authors.affiliation: Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
authors.forename: P
authors.initials: P
authors.lastname: Beak
authors.forename: D R
authors.initials: DR
authors.lastname: Anderson
authors.forename: M D
authors.initials: MD
authors.lastname: Curtis
authors.forename: J M
authors.initials: JM
authors.lastname: Laumer
authors.forename: D J
authors.initials: DJ
authors.lastname: Pippel
authors.forename: G A
authors.initials: GA
authors.lastname: Weisenburger
mesh_terms: D013237:Stereoisomerism; D013816:Thermodynamics