Olanzapine-induced acute pancreatitis.
OBJECTIVE
To report the first published case of olanzapine-induced acute pancreatitis.


METHODS
A 72-year-old white woman was admitted to the intensive care unit (ICU) with acute hemorrhagic pancreatitis and unintentional verapamil overdose. The patient did not consume alcohol and had undergone a cholecystectomy in the past; other medical causes of pancreatitis had been ruled out. She was taking several medications chronically, but olanzapine was started six days prior to the onset of acute abdominal symptoms. According to the Naranjo probability scale, olanzapine was considered the probable cause of acute pancreatitis in this patient. Following a 12-day stay in the ICU, the patient was transferred to the ward where she died a few days later of unrelenting peritonitis secondary to acute pancreatitis.


CONCLUSIONS
A literature search (1966-July 2000) and contact with the manufacturer failed to detect any published reports of acute pancreatitis associated with olanzapine. The contribution of concomitant medications taken prior to ICU admission in initiating or worsening the pancreatitis was deemed unlikely. More common causes of acute pancreatitis, such as ethanol consumption and gallstones, were also ruled out in this patient. Therefore, olanzapine was rated as a probable cause for acute pancreatitis in our patient. The mechanism of this adverse reaction is unknown.


CONCLUSIONS
This is believed to be the first published report suspecting olanzapine, an atypical antipsychotic agent, to have caused acute hemorrhagic pancreatitis in a patient, leading to admission to the ICU and, eventually, death secondary to unrelenting peritonitis.
Doucette
D E
DE
Pharmaceutical Services, Royal Alexandra Hospital, Capital Health Authority, Edmonton, Alberta, Canada. doucette@planet.eon.net
Grenier
J P
JP
Robertson
P S
PS
D000208:Acute Disease; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced / Q000150:complications; D006801:Humans; D000077152:Olanzapine; D010195:Pancreatitis / Q000139:chemically induced* / Q000150:complications; D010890:Pirenzepine / Q000009:adverse effects / Q000031:analogs & derivatives*
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine