title: [Two cases of Trichophyton mentagrophytes infection contracted from a hamster and a chinchilla].
abstract: We report two cases of Trichophyton mentagrophytes infection. Case 1: A 10-year-old girl visited Tokyo Electric Power Hospital in June 1994 for evaluation of an erythematous lesion on her head. Three months of topical steroid therapy exacerbated the lesion with pustular formation. Histopathological and mycological examination revealed that the patient had tinea capitis caused by T. mentagrophytes. T. mentagrophytes was also isolated from her pet, a hamster. Case 2: A-14-year-old girl was referred to Shonan Clinic in January 1996 with scaly erythema on her face. She had been treated with neticonazole hydrochloride at another clinic, but the lesion became worse. Direct microscopic examination of the scale was negative at that time, so treatment with topical steroid was started. After 10 days, the lesion was almost cured, but one month later it recurred with an annular distribution. KOH preparation of the scale revealed mycelia and T. mentagrophytes was isolated on culture. T. mentagrophytes was also isolated from her pet, a chinchilla. In both cases, the oral administration of itraconazole at 50 mg/day was effective. The isolated pathogen was identified as Arthroderma vanbreuseghemii with species-specific primers of chitin synthase 1 gene. T. mentagrophytes is one of the most common dermatophytes isolated from man and animals. Rodents like the hamster and the chinchilla have recently become popular as pets in Japan. We should be aware that rodents may carry this kind of fungal pathogen as they become even more popular as pets.
authors.affiliation: Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjukuku, Tokyo 160-8582, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hata
authors.forename: M
authors.initials: M
authors.lastname: Amagai
authors.forename: W
authors.initials: W
authors.lastname: Naka
authors.forename: R
authors.initials: R
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
mesh_terms: D000293:Adolescent; D000818:Animals; D002648:Child; D002682:Chinchilla; D006224:Cricetinae; D005260:Female; D001841:Human-Animal Bond; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D017111:Phodopus; D012376:Rodent Diseases / Q000382:microbiology / Q000635:transmission*; D014005:Tinea / Q000382:microbiology / Q000635:transmission* / Q000662:veterinary*; D016896:Treatment Outcome; D014249:Trichophyton / Q000302:isolation & purification* / Q000472:pathogenicity
chemical_list: D017964:Itraconazole