title: Hyperfunctioning malignant thyroid nodule in an 11-year-old girl: pathologic and molecular studies.
abstract: We identified a papillary carcinoma in an 11-year-old girl with a hyperfunctioning thyroid nodule. A met453thr mutation in TSHR was found in the nodule but not in normal thyroid tissue or in leukocytes. This case documents that this activating mutation is associated with neoplasia.
authors.affiliation: Sainte-Justine Hospital, University of Montreal, Quebec, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Mircescu
authors.forename: J
authors.initials: J
authors.lastname: Parma
authors.forename: C
authors.initials: C
authors.lastname: Huot
authors.forename: C
authors.initials: C
authors.lastname: Deal
authors.forename: L L
authors.initials: LL
authors.lastname: Oligny
authors.forename: G
authors.initials: G
authors.lastname: Vassart
authors.forename: G
authors.initials: G
authors.lastname: Van Vliet
mesh_terms: D002291:Carcinoma, Papillary; D002648:Child; D005260:Female; D006801:Humans; D009154:Mutation; D013964:Thyroid Neoplasms / Q000150:complications; D016606:Thyroid Nodule / Q000150:complications / Q000235:genetics* / Q000473:pathology