title: Immature myeloid precursors in chronic neutrophilic dermatosis associated with myelodysplastic syndrome.
abstract: Sweet syndrome (SS) associated with myeloproliferative disorders has been considered an inflammatory process mediated by neutrophils in which immunologic mechanisms are operative. The authors report the case of a 68-year-old man suffering from a myelodysplastic syndrome, who presented with a relapsing skin eruption resembling SS. Histopathologically, the skin infiltrates showed prominent neutrophilic features masking the underlying malignant process. Extensive immunophenotypic studies of skin revealed the presence of a few immature myeloid cells intermingled with an overwhelming infiltrate of neutrophils. The atypical cells in the skin had a phenotype identical to that of leukemic cells in the peripheral blood and bone marrow. Whether or not immature myeloid cell precursors constitute a specific infiltrate of leukemia cutis or are a result of recruitment of circulating leukemic cells to this area of inflammation is discussed.
authors.affiliation: Department of Medical and Surgical Specialties, Second Dermatologic Clinic, University of Turin, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Tomasini
authors.forename: F
authors.initials: F
authors.lastname: Aloi
authors.forename: S
authors.initials: S
authors.lastname: Osella-Abate
authors.forename: P
authors.initials: P
authors.lastname: Dapavo
authors.forename: M
authors.initials: M
authors.lastname: Pippione
mesh_terms: D000368:Aged; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000473:pathology; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000473:pathology; D023461:Myeloid Progenitor Cells / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology; D016463:Sweet Syndrome / Q000209:etiology* / Q000473:pathology