title: Discovery of potent cyclic pseudopeptide human tachykinin NK-2 receptor antagonists.
authors.affiliation: Menarini Ricerche S.p.A., Via Sette Santi 3, I-50131 Firenze, Italy. fbenincasa@menarini-richerche.it
authors.forename: D
authors.initials: D
authors.lastname: Giannotti
authors.forename: E
authors.initials: E
authors.lastname: Perrotta
authors.forename: C
authors.initials: C
authors.lastname: Di Bugno
authors.forename: R
authors.initials: R
authors.lastname: Nannicini
authors.forename: N J
authors.initials: NJ
authors.lastname: Harmat
authors.forename: A
authors.initials: A
authors.lastname: Giolitti
authors.forename: R
authors.initials: R
authors.lastname: Patacchini
authors.forename: A R
authors.initials: AR
authors.lastname: Renzetti
authors.forename: L
authors.initials: L
authors.lastname: Rotondaro
authors.forename: S
authors.initials: S
authors.lastname: Giuliani
authors.forename: M
authors.initials: M
authors.lastname: Altamura
authors.forename: C A
authors.initials: CA
authors.lastname: Maggi
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D066298:In Vitro Techniques; D008958:Models, Molecular; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D017354:Point Mutation; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D011869:Radioligand Assay; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: C107754:MEN 11420; D010456:Peptides, Cyclic; D018041:Receptors, Neurokinin-2; C090951:MEN 10627