title: A case of acute myocardial infarction associated with topical use of minoxidil (RiUP) for treatment of baldness.
abstract: A 45-year-old Japanese man with paroxysmal atrial fibrillation (AF) developed acute anteroseptal myocardial infarction (MI). He had used 1% topical minoxidil (RiUP) once a day for 4 months before the onset of MI for treatment of baldness. Coronary angiography demonstrated severe stenosis at the proximal portion of the left anterior descending coronary artery with a tilling defect. Electrocardiographic monitoring revealed paroxysmal AF and sinus bradycardia with sinus arrests, suggestive of sick sinus syndrome. Topical minoxidil is now widely used for the treatment of male pattern baldness. Although it may be difficult to relate topical use of minoxidil to myocardial ischemia, a greater awareness of its toxicity will be necessary, and patients with cardiovascular disorders should be excluded from the therapy.
authors.affiliation: Third Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Satoh
authors.forename: S
authors.initials: S
authors.lastname: Morikaw
authors.forename: C
authors.initials: C
authors.lastname: Fujiwara
authors.forename: H
authors.initials: H
authors.lastname: Terada
authors.forename: A
authors.initials: A
authors.lastname: Uehara
authors.forename: R
authors.initials: R
authors.lastname: Ohno
mesh_terms: D000287:Administration, Topical; D000505:Alopecia / Q000188:drug therapy*; D001281:Atrial Fibrillation / Q000139:chemically induced; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D008914:Minoxidil / Q000009:adverse effects*; D009203:Myocardial Infarction / Q000139:chemically induced*
chemical_list: D008914:Minoxidil