title: Necrotizing granulomata of the aortic valve in Wegener's disease.
abstract: Wegener's disease is an inflammatory disease of unknown etiology, characterized by a granulomatous-necrotizing general vasculitis. Cardiac involvement in the form of aortic pathology is not frequent. We report a case of Wegener's granulomatosis which required prosthetic aortic valve replacement for aortic valve insufficiency. Microscopic examination of the valve demonstrated histopathology typical of Wegener's disease.
authors.affiliation: Thoracic and Cardiovascular Surgery Department, University Hospital Caen, France.
authors.forename: P
authors.initials: P
authors.lastname: Bruno
authors.forename: C
authors.initials: C
authors.lastname: Le Hello
authors.forename: M
authors.initials: M
authors.lastname: Massetti
authors.forename: G
authors.initials: G
authors.lastname: Babatasi
authors.forename: E
authors.initials: E
authors.lastname: Saloux
authors.forename: F
authors.initials: F
authors.lastname: Galateau
authors.forename: A
authors.initials: A
authors.lastname: Khayat
mesh_terms: D001021:Aortic Valve / Q000473:pathology*; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000601:surgery; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000473:pathology*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008875:Middle Aged; D009336:Necrosis