Toxoplasma gondii Hsp70 as a danger signal in toxoplasma gondii-infected mice.
Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-gamma knockout mice infected with T gondii. Tgondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection.
Mun
H S
HS
Department of Parasitology, Chiba University School of Medicine, Japan.
Aosai
F
F
Norose
K
K
Chen
M
M
Hata
H
H
Tagawa
Y I
YI
Iwakura
Y
Y
Byun
D S
DS
Yano
A
A
D000818:Animals; D000953:Antigens, Protozoan; D050890:HSP30 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000302:isolation & purification*; D006360:Heat-Shock Proteins / Q000235:genetics / Q000302:isolation & purification; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000235:genetics / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009569:Nitric Oxide / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics / Q000302:isolation & purification*; D012333:RNA, Messenger / Q000302:isolation & purification; D016053:RNA, Protozoan / Q000302:isolation & purification; D014124:Toxoplasmosis, Animal / Q000401:mortality*
D000953:Antigens, Protozoan; C106179:BAG1 protein, Toxoplasma; D050890:HSP30 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D008565:Membrane Proteins; D015800:Protozoan Proteins; D012333:RNA, Messenger; D016053:RNA, Protozoan; C047168:SAG1 antigen, Toxoplasma; D009569:Nitric Oxide; D007371:Interferon-gamma