Influence of alpha-adrenoceptor blockade on antigen- and propranolol-induced bronchoconstriction in guinea-pigs in vivo.
1. Beta-adrenoceptor antagonists, such as propranolol, can provoke severe bronchoconstriction only in asthmatic subjects. Recently, we developed a guinea-pig model of propranolol-induced bronchoconstriction (PIB) and the purpose of this study was to investigate the role of alpha-adrenergic nerve pathways in this reaction. 2. Phentolamine administered after an antigen challenge did not inhibit PIB; however, its administration before the antigen challenge significantly inhibited the antigen-induced bronchoconstriction and also bronchoconstriction induced by methacholine inhalation. 3. We conclude that the alpha-adrenergic nerve system is not involved in the development of PIB following allergic reaction in our guinea-pig model.
Ishiura
Y
Y
The Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan.
Fujimura
M
M
Myou
S
S
Amemiya
T
T
Nobata
K
K
Liu
Q
Q
Yamamori
C
C
D000280:Administration, Inhalation; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D000941:Antigens / Q000494:pharmacology*; D016084:Bronchoconstriction / Q000187:drug effects*; D016085:Bronchoconstrictor Agents / Q000494:pharmacology; D005541:Forced Expiratory Volume / Q000187:drug effects; D006168:Guinea Pigs; D007116:Immunization, Passive; D066298:In Vitro Techniques; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology; D010047:Ovalbumin / Q000276:immunology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D012121:Respiration, Artificial
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000941:Antigens; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D010047:Ovalbumin; D011433:Propranolol; D010646:Phentolamine