title: Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.
abstract: Human platelets diadenosine triphosphatase was characterised and compared with the Fhit protein, a human tumour suppressor with diadenosine triphosphatase activity. Both enzymes exhibit similar Km, are similarly activated by Mg2+, Ca2+ and Mn2+, and inhibited by Zn2+ and suramin. However, they are differentially inhibited by Fhit antibodies and exhibit differences in gel-filtration behaviour.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Canary Islands, Spain.
authors.forename: A C
authors.initials: AC
authors.lastname: Asensio
authors.forename: C R
authors.initials: CR
authors.lastname: Rodríguez-Ferrer
authors.forename: S
authors.initials: S
authors.lastname: Oaknin
authors.forename: P
authors.initials: P
authors.lastname: Rotllán
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000097:blood* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology; D002413:Cations, Divalent / Q000494:pharmacology; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D009363:Neoplasm Proteins; D011506:Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D013050:Spectrometry, Fluorescence; D015032:Zinc / Q000494:pharmacology; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D002118:Calcium; D002413:Cations, Divalent; D008274:Magnesium; D008345:Manganese; D009363:Neoplasm Proteins; D011506:Proteins; D015032:Zinc; D000099170:Bis(5'-adenosyl)triphosphatase