title: Role of nitric oxide and prostaglandins in the bone formation response to mechanical loading.
abstract: Nitric oxide and prostaglandins are crucial early mediators in mechanically induced bone formation. They are also responsible for the associated induction of gene expression of c-fos and IGF-1 in osteocytes, key mechanosensory cells in bone. Insight into the cellular and molecular mechanisms underlying bone formation has important implications for the maintenance of structural competence of bone.
authors.affiliation: Histopathology Department, St George's Hospital Medical School, London, UK. j.chow@sghms.ac.uk
authors.forename: J W
authors.initials: JW
authors.lastname: Chow
mesh_terms: D000818:Animals; D001846:Bone Development / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D015870:Gene Expression; D016762:Genes, fos / Q000235:genetics; D009569:Nitric Oxide / Q000502:physiology*; D010011:Osteocytes / Q000166:cytology; D010012:Osteogenesis / Q000502:physiology; D010812:Physical Stimulation; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D011453:Prostaglandins; D009569:Nitric Oxide