title: More aggressive behavior of squamous cell carcinoma of the anterior tongue in young women.
abstract: OBJECTIVE
  To review the combined experience from two large medical centers in treating young female patients with anterior tongue cancer to determine the clinical course of this unique subset of patients.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Seventeen female patients less than 40 years of age (group A) and 17 older patients, both male and female, greater than 40 years of age (group B) who had treatment for invasive squamous cell carcinoma of the anterior tongue were studied. The charts were reviewed for the clinical staging, treatment, and outcome of each patient. The disease-free survival and recurrence rates were compared between the two cohorts.
  
  
  RESULTS
  The mean disease stage between the groups was II. The survival analysis showed a significant difference between the two groups in recurrences (group A = 65%, group B = 41%; P = .02). Further, of the patients who had recurrence, the young women did so significantly earlier in their disease course than the older patients (group A = 14 mo, group B = 40 mo; P < .05). Although the survival differences did not reach statistical significance (P = .15), the power of the study was low (power = 0.26) resulting in a high-level type II error.
  
  
  CONCLUSIONS
  These data suggest that young women with squamous cell carcinoma of the anterior tongue have significantly higher rates of recurrent disease and the interval to recurrence is significantly shorter than in older patients. Further investigation is warranted until a statistically significant cohort is accrued; until that time, these patients warrant an aggressive initial treatment and close surveillance for recurrence.
authors.affiliation: Division of Otolaryngology--Head and Neck Surgery, Albany Medical Center, New York, USA.
authors.forename: H
authors.initials: H
authors.lastname: Vargas
authors.forename: K T
authors.initials: KT
authors.lastname: Pitman
authors.forename: J T
authors.initials: JT
authors.lastname: Johnson
authors.forename: L T
authors.initials: LT
authors.lastname: Galati
mesh_terms: D000293:Adolescent; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D014062:Tongue Neoplasms / Q000401:mortality / Q000473:pathology*