title: Personal exposure to nitrogen dioxide and risk of airflow obstruction in asthmatic children with upper respiratory infection.
abstract: BACKGROUND
  Several studies have linked air pollution by nitrogen dioxide (NO(2)) with increased hospital admissions for asthma in children. Exacerbations of asthma in children are often precipitated by upper respiratory infections. It is therefore possible that NO(2) increases the risk of airways obstruction when asthmatic children develop upper respiratory infections.
  
  
  METHODS
  To test this hypothesis a sample of 114 asthmatic children aged 7-12 years were followed for a total of up to 13 months. Probable upper respiratory infections were identified by consensus review of daily symptom diaries, and episodes of airways obstruction from serial records of peak expiratory flow (PEF). Personal exposures to NO(2) were measured with Palmes tubes that were changed weekly. Generalised estimating equations were used to assess the relative risk (RR) of an asthmatic exacerbation starting within seven days of an upper respiratory infection according to estimated NO(2) exposure during the one week period from two days before to four days after the onset of the infection.
  
  
  RESULTS
  The children were followed for an average of 34 weeks during which 318 upper respiratory infections and 224 episodes of reduced PEF were diagnosed. PEF episodes were much more likely to occur in the seven days following the onset of an upper respiratory infection than at other times. Estimated exposures to NO(2) at the time of infections were generally low (geometric mean 10.6 microg/m(3)). Compared with exposures of < or = 8 microg/m(3), exposures of >28 microg/m(3) were associated with a RR of 1.9 (95% confidence interval 1.1 to 3.4) for the development of an asthmatic episode within seven days of an infection.
  
  
  CONCLUSIONS
  The findings give some support to the hypothesis that NO(2) increases the risk of asthmatic exacerbations following respiratory infections, even at relatively low levels of exposure. Further studies in populations with higher exposures would be useful.
authors.affiliation: MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
authors.forename: C H
authors.initials: CH
authors.lastname: Linaker
authors.forename: D
authors.initials: D
authors.lastname: Coggon
authors.forename: S T
authors.initials: ST
authors.lastname: Holgate
authors.forename: J
authors.initials: J
authors.lastname: Clough
authors.forename: L
authors.initials: L
authors.lastname: Josephs
authors.forename: A J
authors.initials: AJ
authors.lastname: Chauhan
authors.forename: H M
authors.initials: HM
authors.lastname: Inskip
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects; D000402:Airway Obstruction / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D001249:Asthma / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D002648:Child; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009585:Nitrogen Dioxide / Q000009:adverse effects*; D010083:Oxidants, Photochemical / Q000009:adverse effects*; D010366:Peak Expiratory Flow Rate / Q000502:physiology; D012141:Respiratory Tract Infections / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D000393:Air Pollutants; D010083:Oxidants, Photochemical; D009585:Nitrogen Dioxide