Regulated workplace ketones and their interference in the PFBHA method for aldehydes.
Ketones are the major positive interferences for an aldehyde dynamic air sampler that consists of 200-mg 20 percent (w/w) O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) on Tenax TA contained in a Pyrex tube 7-mm OD, 5-mm ID, and 70-mm in length, that utilizes a personal battery-powered pump at 10-50 mL/min. The ketone O-oxime derivatives were synthesized to allow absolute quantitation of O-oximes formed during sampling. Wet spiking allowed ketone recoveries to be found. Ketone vapors of known concentrations were generated statically in Tedlar gas bags. The O-oximes were desorbed with hexane, and an aliquot injected for gas chromatographic analysis on a nonpolar capillary column with mass spectrometric or electron capture detection. Gas phase recoveries up to 200 ppm-hour loadings exceeded 75 percent at 25 degrees C for chloroacetone, cyclohexanone, diacetone alcohol, diethyl ketone, dipropyl ketone, ethyl butyl ketone, methyl amyl ketone, methyl butyl ketone, 2-methylcyclohexanone, methyl ethyl ketone, methyl isobutyl ketone, methyl isopropyl ketone, and methyl propyl ketone. The recoveries for acetophenone, 2-chloroacetophenone, and ethyl amyl ketone were lower than 75 percent, and were caused by steric hindrance. Sampling for both aldehydes and ketones is recommended at 10 mL/min for TLV concentrations.
Lin
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YW
UCLA School of Public Health, USA.
Hee
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SS
D016902:Air Pollution, Indoor / Q000032:analysis*; D000447:Aldehydes / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods; D006898:Hydroxylamines / Q000493:pharmacokinetics*; D007202:Indicators and Reagents / Q000493:pharmacokinetics*; D007659:Ketones / Q000032:analysis*; D017132:Workplace; D005466:Fluorocarbons
D000447:Aldehydes; D006898:Hydroxylamines; D007202:Indicators and Reagents; D007659:Ketones; C010277:Florox Reagent; D005466:Fluorocarbons