title: Tubulointerstitial nephritis and asymptomatic uveitis.
abstract: We describe a case of a 10 year-old boy who had fever, weakness, anorexia, weight loss and general malaise. No other remarkable symptoms were present. He had been treated with Aspirin and Ibuprofen. Deterioration of renal function, glucosuria, proteinuria, anemia and increased erythrocyte sedimentation rate were detected. After 7 days observation with no treatment, renal function worsened, glucosuria increased and fever persisted. A renal biopsy was performed and acute tubulointerstitial nephritis was diagnosed. The most common aetiologies of this entity were excluded. An ophthalmologic study revealed bilateral anterior uveitis, therefore the patient was diagnosed as having tubulointerstitial nephritis with uveitis. The child improved on corticosteroid therapy, but uveitis relapsed when treatment was stopped.
authors.affiliation: Department of Nephrology, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain. ngallego@hrc.insalud.es
authors.forename: N
authors.initials: N
authors.lastname: Gallego
authors.forename: R
authors.initials: R
authors.lastname: Estepa
authors.forename: F
authors.initials: F
authors.lastname: Mampaso
authors.forename: F
authors.initials: F
authors.lastname: García-S
authors.forename: A
authors.initials: A
authors.lastname: Reche
authors.forename: J
authors.initials: J
authors.lastname: Ortuño
mesh_terms: D001707:Biopsy, Needle; D001774:Blood Chemical Analysis; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D012720:Severity of Illness Index; D016896:Treatment Outcome; D016482:Urinalysis; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D011241:Prednisone