Construction of chiral 1,2-cycloalkanopyrrolidines from L-proline using ring closing metathesis (RCM).
An efficient synthetic method for the preparation of optically active pyrroloazocine, pyrroloazepine, quinolizidine, indolizidine using ring closing olefin metathesis (RCM) is described.
Arisawa
M
M
Faculty of Pharmaceutical Sciences, Chiba University, Japan.
Takahashi
M
M
Takezawa
E
E
Yamaguchi
T
T
Torisawa
Y
Y
Nishida
A
A
Nakagawa
M
M
D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013057:Spectrum Analysis; D013237:Stereoisomerism
D011759:Pyrrolidines; D011392:Proline