title: Expression of brain/kidney protein in Müller cells of rat retina following transient ischemia.
abstract: We have investigated the expression and cellular localization of brain/kidney (B/K) protein in the rat retina following transient ischemia. In the normal retina, strong B/K immunoreactivity was localized to some ganglion cells. In addition, a few radial Muller cell processes showed B/K immunoreactivity. Following ischemia and reperfusion, most B/K-labeled ganglion cells were lost, whereas between 1 day and 2 weeks post-lesion B/K immunoreactivity appeared in many more Muller cell processes with increasing intensity. Quantitative evaluation by immunoblotting confirmed that B/K expression then decreased progressively, to 35% of control values at four weeks post-lesion. Our findings suggest that Muller cells are involved in the pathophysiology of retinal ischemia through the expression of B/K following transient ischemia.
authors.affiliation: Department of Anatomy, College of Medicine, The Catholic University of Korea, Socho-gu, Seoul.
authors.forename: W K
authors.initials: WK
authors.lastname: Ju
authors.forename: S H
authors.initials: SH
authors.lastname: Choi
authors.forename: J S
authors.initials: JS
authors.lastname: Kwon
authors.forename: O J
authors.initials: OJ
authors.lastname: Kwon
authors.forename: M Y
authors.initials: MY
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Oh
authors.forename: J L
authors.initials: JL
authors.lastname: Moon
authors.forename: M H
authors.initials: MH
authors.lastname: Chun
mesh_terms: D000818:Animals; D015151:Immunoblotting; D007511:Ischemia / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology; D012160:Retina / Q000378:metabolism* / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000378:metabolism*; D012171:Retinal Vessels; D050857:Synaptotagmins; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D009419:Nerve Tissue Proteins; C409229:Syt17 protein, rat; D050857:Synaptotagmins