title: The influence of ergotamine abuse on psychological and cognitive functioning.
abstract: Migraine patients abusing ergotamine often have chronic daily headaches associated with tiredness, sleep and memory disturbances, and reduced general well-being. We quantified psychological and cognitive functioning in 12 migraine patients with and 12 without ergotamine abuse (> or = 5 days/week for > or = 6 months) and 12 healthy controls. Psychological functioning assessed by Symptom Checklist-90 (SCL-90) and Profile Of Mood State (POMS), was impaired in ergotamine abusers compared to healthy controls. Cognitive functioning divided into four domains: attention (critical flicker frequency analysis and mental control subscale of the Wechsler Memory Scale (WMS), speed of information processing (reaction time tasks and lexical decision tasks), memory (four subscales of the WMS) and cognitive flexibility (trailmaking test and WMS digits backwards), was impaired in ergotamine abusers in speed of information processing and cognitive flexibility. These differences disappeared after correction for total SCL-90 scores. In conclusion, ergotamine abuse is associated with high psychological distress but not with structural impaired cognitive functioning.
authors.affiliation: Department of Neurology, Leiden University Medical Center, The Netherlands.
authors.forename: K I
authors.initials: KI
authors.lastname: Roon
authors.forename: D
authors.initials: D
authors.lastname: Bakker
authors.forename: M I
authors.initials: MI
authors.lastname: van Poelgeest
authors.forename: M A
authors.initials: MA
authors.lastname: van Buchem
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
authors.forename: H A
authors.initials: HA
authors.lastname: Middelkoop
mesh_terms: D003071:Cognition / Q000187:drug effects*; D004878:Ergotamine / Q000009:adverse effects*; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D011581:Psychological Tests; D012016:Reference Values; D013315:Stress, Psychological / Q000139:chemically induced; D013375:Substance Withdrawal Syndrome / Q000523:psychology; D019966:Substance-Related Disorders / Q000523:psychology*
chemical_list: D004878:Ergotamine