[Comparative studies on pharmacological and toxic actions of raw fructus Psoraleae and its salt-baked and improved salt-baked products].
The pharmacological and toxic actions of raw Fructus Psoraleae and its salt-baked, and improved salt-baked products were comparatively studied. The leucogenic action of the improved salt-baked product was more effective than that of the original salt-baked one. But no significant difference in antidiarrheal or antiandrogenoid effect was found between the two salt-baked products. The toxicity(LD50 and the injury on kidney) of the improved salt-baked product was lower than that of the salt-baked. one. The results indicate that this improved processing method would contribute to increasing the efficacy and decreasing the toxicity of Fructus Psoraleae.
Yao
X
X
Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing.
Shen
H
H
Fu
H
H
Wu
Z
Z
Zhang
Y
Y
Hui
L
L
D000726:Androgen Antagonists; D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000633:toxicity; D007887:Fabaceae; D006358:Hot Temperature; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D007970:Leukopenia / Q000188:drug therapy; D008297:Male; D051379:Mice; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride; D013678:Technology, Pharmaceutical / Q000379:methods
D000726:Androgen Antagonists; D000930:Antidiarrheals; D004365:Drugs, Chinese Herbal; D012965:Sodium Chloride