An analysis of the effect of age on implantation rates.
OBJECTIVE
To evaluate implantation rate as a function of age.


METHODS
A total of 1621 consecutive cycles of IVF were evaluated for implantation as a function of age at The New York Hospital/Cornell Medical Center.


RESULTS
An overall implantation rate of 23.3% (1328/5691) was found. The implantation rate as a function of age decreased in a nonlinear fashion. Implantation remained constant until the age of 35 and then decreased in a significantly, linear fashion by 2.77% per year (P < 0.001, R2 = 0.975). A formula to predict implantation rates for a given age was developed: Implantation rate = -119.352 + (9.985 x Age - (0.164 x Age2)).


CONCLUSIONS
We have demonstrated that implantation rates remain constant until the age of 35 at which time a linear decrease of 2.77% per year is observed.
Spandorfer
S D
SD
Center for Reproductive Medicine and Infertility, New York Hospital/Cornell Medical Center, New York 10021, USA.
Chung
P H
PH
Kligman
I
I
Liu
H C
HC
Davis
O K
OK
Rosenwaks
Z
Z
D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer / Q000706:statistics & numerical data*; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D006801:Humans; D007246:Infertility / Q000209:etiology; D008297:Male; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D012044:Regression Analysis; D012189:Retrospective Studies