Effect of batroxobin on expression of c-Jun in left temporal ischemic rats with spatial learning and memory disorder.
The effect of Batroxobin on expression of c-Jun in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats, and at the same time c-Jun expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of c-Jun immune reactive cells of Batroxobin-treated rats was also less than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder in temporal ischemic rats, and the down-regulation of the expression of c-Jun is probably related to the neuroprotective mechanism.
Wu
W
W
Department of Neurology, Chinese PLA General Hospital, Postgraduate Military Medical School, Beijing.
Kuang
P
P
Jiang
S
S
Yang
J
J
Sui
N
N
Chen
A
A
Kuang
P
P
Zhang
X
X
D000818:Animals; D012103:Batroxobin / Q000494:pharmacology*; D015870:Gene Expression; D016758:Genes, jun; D020925:Hypoxia-Ischemia, Brain / Q000235:genetics*; D008297:Male; D008569:Memory Disorders / Q000150:complications*; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013702:Temporal Lobe / Q000098:blood supply
D016755:Proto-Oncogene Proteins c-jun; D012103:Batroxobin