Progesterone side-chain cleavage by Bacillus sphaericus.
The side-chain of progesterone was cleaved by Bacillus sphaericus to produce two C-19 keto androstene steroids. The structures of these metabolites were androstenedione and 1-dehydroandrostenedione. High concentrations of glucose in the culture medium inhibited conversion of progesterone to these two metabolites.
Wadhwa
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Molecular and Cellular Biology, Division of Biomedical Sciences, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, Mile End Road, E1 4NS, London, UK.
Smith
K E
KE
D000735:Androstenedione / Q000032:analysis / Q000737:chemistry; D001407:Bacillus / Q000378:metabolism*; D001711:Biotransformation; D002855:Chromatography, Thin Layer; D005947:Glucose / Q000494:pharmacology; D015394:Molecular Structure; D011374:Progesterone / Q000378:metabolism*
D000735:Androstenedione; D011374:Progesterone; D005947:Glucose