title: A physical model of the human systemic arterial tree.
abstract: A physical model of the human arterial tree has been developed to be used in a computer controlled mock circulatory system (MCS). Its aim is to represent systemic arterial tree properties and extend the capacity of the MCS to intraortic balloon pump (IABP) testing. The main problem was to model the aorta simply and to accurately reproduce aortic impedance and related flow and pressure waveforms at different sections. The model is composed of eight segments; lumped parameter models are used for its peripheral loads. After the numerical simulation, the physical model was reproduced as a silicon rubber tapered tube. This rubber was chosen for its stability over time and the acceptable behaviour of its Young's modulus (Ey = 22.23 gf x mm(-2)) with different loads and in comparison with data from the literature (Ey approximately 20.4 gf x mm(-2)). The properties of each segment of the aorta were defined in terms of compliance, resistance and inertance as a function of length, radius and thickness. The variable thickness was obtained using positive and negative molds. Total static compliance of the aorta model is about 1.125 x 10(-3) g(-1) x cm4 x sec2 (1.5 cm3 x mmHg(-1)). Measurements were performed both on numerical and physical models (in open and closed loop configuration). Data reported show pressure and flow waveforms along with input impedance modulus and phase. The results are in good agreement with data from the literature.
authors.affiliation: Institute of Biomedical Technologies, CNR, Roma, Italy. gfr@itbm.rm.cnr.it
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: A
authors.initials: A
authors.lastname: Nicoletti
authors.forename: C
authors.initials: C
authors.lastname: De Lazzari
authors.forename: F
authors.initials: F
authors.lastname: Clemente
authors.forename: G
authors.initials: G
authors.lastname: Tosti
authors.forename: M
authors.initials: M
authors.lastname: Guaragno
authors.forename: R
authors.initials: R
authors.lastname: Mimmo
authors.forename: D
authors.initials: D
authors.lastname: Ambrosi
authors.forename: K
authors.initials: K
authors.lastname: Górczyńska
mesh_terms: D001011:Aorta / Q000502:physiology; D001158:Arteries / Q000033:anatomy & histology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D014655:Vascular Resistance / Q000502:physiology