Variance-Components QTL linkage analysis of selected and non-normal samples: conditioning on trait values.
Standard variance-components quantitative trait loci (QTL) linkage analysis can produce an elevated rate of type 1 errors when applied to selected samples and non-normal data. Here we describe an adjustment of the log-likelihood function based on conditioning on trait values. This leads to a likelihood ratio test that is valid in selected samples and non-normal data, and equal in power to alternative methods for analyzing selected samples that require knowledge of the ascertainment procedure or the trait values of non-selected individuals.
Sham
P C
PC
Social, Genetic and Developmental Psychiatry Research Center and Department of Psychiatry, Institute of Psychiatry, Denmark Hill, London, United Kingdom. p.sham@iop.kcl.ac.uk
Zhao
J H
JH
Cherny
S S
SS
Hewitt
J K
JK
D000704:Analysis of Variance; D003198:Computer Simulation; D008040:Genetic Linkage; D019655:Quantitative Trait, Heritable