Receptors coupling to G proteins: is there a signal behind the sequence?
Upon the binding of their ligands, G protein-coupled receptors couple to the heterotrimeric G proteins to transduce a signal. One receptor family may couple to a single G protein subtype and another family to several ones. Is there a signal in the receptor sequence that can give an indication of the G protein subtype selectivity? We used a sequence analysis method on biogenic amine and adenosine receptors and concluded that a weak signal can be detected in receptor families where specialization for coupling to a given G protein occurred during a recent divergent evolutionary process. Proteins 2000;41:448-459.
Horn
F
F
BIOcomputing, European Molecular Biology Laboratory, Heidelberg, Germany.
van der Wenden
E M
EM
Oliveira
L
L
IJzerman
A P
AP
Vriend
G
G
D000465:Algorithms; D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence / Q000502:physiology; D016208:Databases, Factual; D019143:Evolution, Molecular; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D009154:Mutation / Q000502:physiology; D010802:Phylogeny; D011941:Receptors, Adrenergic / Q000737:chemistry; D017982:Receptors, Biogenic Amine / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000737:chemistry*; D011976:Receptors, Muscarinic / Q000737:chemistry; D018047:Receptors, Purinergic P1 / Q000737:chemistry; D015398:Signal Transduction
D008024:Ligands; D011941:Receptors, Adrenergic; D017982:Receptors, Biogenic Amine; D011956:Receptors, Cell Surface; D011976:Receptors, Muscarinic; D018047:Receptors, Purinergic P1; D019204:GTP-Binding Proteins