[The importance of advanced glycosylation end products in the creation and progression of atherosclerosis in non-insulin-dependent diabetes mellitus].
Diabetic macroangiopathy is a major cause of morbidity and mortality of patients with non-insulindependent diabetes mellitus. Bad metabolic control of diabetes increases the risk of developing atherosclerotic complications. Hyperglycemia aids to increase the process of non-enzymatic protein glycosylation. Advanced glycation end products (AGEs) created in Maillard reaction play multidirectional role in creation of atherosclerosis in NIDDM. AGEs form in LDL, HDL and VLDL particles and increase their oxidative modification. They aid deposition of cholesterol and its esters in macrophages as well as creation of foam cells. Reaction of LDL-AGE particles with proteoglycans of blood vessel intima results in its thickening. LDL-AGE and ox-LDL take part in formation of late atherosclerotic changes influencing the expression of genes for cytokines and growth factors. AGEs promote prothrombotic changes. They block formation of nitric oxide which results in impaired vessel relaxation. They also take part in progressive vessel narrowing up to complete vessel occlusion by atheroslerotic plaque.
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Oddział Chorób Wewnetrznych Szpitala w Radzyminie.
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D001161:Arteriosclerosis / Q000150:complications* / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism*; D018450:Disease Progression; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans
D017127:Glycation End Products, Advanced