Cocaine use and the mid-latency auditory evoked responses.
To examine the effects of chronic cocaine use on the mid-latency auditory evoked responses (MLAERs), we recorded the evoked responses of 15 cocaine-dependent subjects and 13 age-matched healthy control subjects. Two evoked response paradigms were used: a trains paradigm with four different inter-stimulus intervals (ISIs) and a paired-click paradigm. Our data suggest that cocaine-dependent subjects generate smaller P50 components when long ISIs are used with multiple repetitions (in the trains paradigm). In a single repetition paradigm (paired clicks), a significant decrease in the ability to attenuate the N100 component was seen in the cocaine-dependent subjects.
Boutros
N
N
Department of Psychiatry (116A), Yale University School of Medicine and VA Connecticut Healthcare System, 950 Campbell Avenue, 06516, West Haven, CT, USA. nash@boutros@yale.edu
Campbell
D
D
Petrakis
I
I
Krystal
J
J
Caporale
M
M
Kosten
T
T
D000161:Acoustic Stimulation; D000328:Adult; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D004298:Dopamine / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects* / Q000502:physiology; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted
D004298:Dopamine; D009638:Norepinephrine