title: Three fatal pneumococcal polysaccharide vaccine failures.
abstract: Three Indigenous Australian adults died of invasive pneumococcal disease, despite vaccination with the pneumococcal polysaccharide vaccine an average of 18 months previously. Pneumococcal isolates from the patients had serotypes that are included in the vaccine. Two of the adults were alcoholics and the other had heavy recent alcohol intake. The public health implications, and possible optimal vaccination schedules to minimise vaccine failures, are discussed.
authors.affiliation: Tropical Public Health Unit, Queensland Health, Cairns. jeffery_hanna@health.qld.gov.au
authors.forename: J N
authors.initials: JN
authors.lastname: Hanna
authors.forename: D J
authors.initials: DJ
authors.lastname: Wenck
authors.forename: D N
authors.initials: DN
authors.lastname: Murphy
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000276:immunology / Q000401:mortality; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D011018:Pneumonia, Pneumococcal / Q000276:immunology / Q000401:mortality* / Q000517:prevention & control; D011793:Queensland; D018805:Sepsis / Q000276:immunology / Q000401:mortality / Q000517:prevention & control; D017211:Treatment Failure; D000095283:Australian Aboriginal and Torres Strait Islander Peoples
chemical_list: D022242:Pneumococcal Vaccines