[Effect of ofloxacin, pefloxacin, and tobramycin on the hydrophobicity of Klebsiella pneumoniae].
The effect of ofloxacin, pefloxacin and tobramycin at subinhibitory concentrations (1/4, 1/8 and 1/16 of the MICs) on surface hydrophobicity of the Klebsiella pneumoniae strain was studied. The antibiotics tested decreased cell surface hydrophobicity in a dose-dependent manner. The most significant reduction of surface hydrophobicity was found after treatment with antibiotics at 1/4 of their MICs. Surface hydrophobicity of K. pneumoniae after exposure to these concentrations was decreased to 44% (ofloxacin), 50.7% (pefloxacin) and 56.1% (tobramycin) compared with controls.
Hostacká
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Ustav preventívnej a klinickej medicíny, Bratislava.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000502:physiology; D015242:Ofloxacin / Q000494:pharmacology*; D015366:Pefloxacin / Q000494:pharmacology*; D014031:Tobramycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015366:Pefloxacin; D015242:Ofloxacin; D014031:Tobramycin