Personality traits predict treatment outcome with an antidepressant in patients with functional gastrointestinal disorder.
BACKGROUND
We investigated the relationship between personality traits and response to treatment with the tetracyclic antidepressant mianserin or placebo in patients with functional gastrointestinal disorder (FGD) without psychopathology.


METHODS
Forty-eight patients completed the Buss-Durkee Hostility Inventory, Neuroticism Extroversion Openness -Personality Inventory (NEO-PI), and Eysenck Personality Questionnaire (EPQ), neuroticism + lie subscales, before they were consecutively allocated to a 7-week double-blind treatment study with mianserin or placebo. Treatment response to pain and target symptoms were recorded daily with the Visual Analogue Scale and Clinical Global Improvement Scale at every visit.


RESULTS
A low level of neuroticism and little concealed aggressiveness predicted treatment outcome with the antidepressant drug mianserin in non-psychiatric patients with FGD. Inversely, moderate to high neuroticism and marked concealed aggressiveness predicted poor response to treatment. These findings were most prominent in women. Personality traits were better predictors of treatment outcome than serotonergic sensitivity assessed with the fenfluramine test.


CONCLUSIONS
Assessment of the personality traits negativism, irritability, aggression, and neuroticism may predict response to drug treatment of FGD even when serotonergic sensitivity is controlled for. If confirmed in future studies, the findings point towards a more differential psychopharmacologic treatment of FGD.
Tanum
L
L
Dept. of Psychosomatic and Behavioural Medicine, Rikshospitalet, Oslo, Norway.
Malt
U F
UF
D000328:Adult; D000368:Aged; D000374:Aggression; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D003109:Colonic Diseases, Functional / Q000188:drug therapy* / Q000523:psychology*; D004415:Dyspepsia / Q000188:drug therapy* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000627:therapeutic use*; D008875:Middle Aged; D009497:Neurotic Disorders; D010551:Personality; D010552:Personality Assessment; D011237:Predictive Value of Tests; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D008803:Mianserin