[The role of lysosomal proteinases in blood system reactions during inflammation].
On the model of carrageenan-induced acute aseptic peritonitis in rats it is shown that in inflammation on the background of contrykal administration the accumulation and stimulation of leukocytes of an inflammatory focus, and the activation of granulomonocytopoiesis and of blood leukocytes are increased, and infiltration becomes calm earlier. The results indicate that in the natural development of inflammation lysosomal proteinases limit the accumulation and stimulation of leukocytes of an inflammatory focus, and activation of granulomonocytopoiesis and of blood leukocytes, and prolong the inflammatory reaction, i.e. they inhibit the protective adaptive reactions of blood in inflammation.
Klymenko
M O
MO
Kharkov Medical University.
Shevchenko
O M
OM
D000208:Acute Disease; D000818:Animals; D007611:Aprotinin; D002351:Carrageenan; D004195:Disease Models, Animal; D010450:Endopeptidases / Q000097:blood*; D007958:Leukocyte Count; D019891:Leukopoiesis / Q000187:drug effects; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D010538:Peritonitis / Q000097:blood* / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D015842:Serine Proteinase Inhibitors; D013997:Time Factors
D015842:Serine Proteinase Inhibitors; D002351:Carrageenan; D007611:Aprotinin; D010450:Endopeptidases