Myocardial fixation of anticardiac troponin I antibody and cardiac troponin I release.
BACKGROUND
The threefold aim of this experimental study was to test the correlation of cardiac troponin I released to myocardial infarction size and myocardial fixation of anticardiac troponin I antibody and to determine how long after myocardial infarction the measure of cardiac troponin I concentration can evaluate myocardial infarction size.


METHODS
Forty rabbits were assigned either to a control group or to an experimental preconditioned group. Infarction was obtained by tightening a snare around the left anterior descending artery. Serial venous blood samples were drawn for measurement of cardiac troponin I. The rabbits were sacrificed at 72 hours and a histological study was performed to determine the infarct size and the size of the area void of fixation of anticardiac troponin I antibody.


RESULTS
There was a linear correlation between the total amount of CTn I released and both infarct size (r=0.45, p<0.02) and the size of the area void of anti-cardiac troponin I antibody (r=0.47, p<0.02). These two sizes were strongly correlated (r=0.95, p<0.02). The hour 9 CTn I sample was the best correlated with both the infarct size (r=0.47, p<0.02) and the size of area void of anticardiac troponin I antibody (r=0.45, p<0.02).


CONCLUSIONS
Our study shows that: 1) cardiac troponin I release is correlated to both myocardial infarction size and the size of area void of fixation of anticardiac troponin I antibody, 2) the area void of anticardiac troponin I antibody fixation includes the whole ischemic area, and 3) evaluation of myocardial infarction size can be obtained by CTn I concentration as early as the ninth hour.
Alwan
K
K
Department of Thoracic and Cardiovascular Surgery, Saint-Jacques Hospital, Besançon, France.
Chocron
S
S
Mourand
J L
JL
Toubin
G
G
Gauchez
P
P
Kantelip
B
B
Kantelip
J P
JP
Etievent
J P
JP
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D007150:Immunohistochemistry; D019157:Ischemic Preconditioning, Myocardial; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000737:chemistry*; D011817:Rabbits; D013997:Time Factors; D019210:Troponin I / Q000032:analysis / Q000276:immunology / Q000378:metabolism*
D000906:Antibodies; D019210:Troponin I