title: Opioid peptide modulation of circulatory response to hyperventilation in humans.
abstract: After hyperventilation, systolic blood pressure (SBP) significantly decreased in 10 subjects (group 1), did not change in eight (group 2) and increased in 15 (group 3). Diastolic blood pressure and heart rate increased in all groups. The decrease in SBP was associated with a decrease in plasma catecholamines and increase in beta-endorphin, whereas the increase in SBP was accompanied by an increase in catecholamine and Met-enkephalin levels. Naloxone abolished the hyperventilation-induced SBP and catecholamine decrease only in group 1. These findings show an activation of the endogenous opioid system after hyperventilation and the role of beta-endorphin in reducing SBP in response to the test.
authors.affiliation: Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Ospedale S. Orsola, Via Massarenti 9, 40138 Bologna, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fontana
authors.forename: P
authors.initials: P
authors.lastname: Bernardi
authors.forename: E M
authors.initials: EM
authors.lastname: Pich
authors.forename: L
authors.initials: L
authors.lastname: Tartuferi
authors.forename: S
authors.initials: S
authors.lastname: Boschi
authors.forename: S
authors.initials: S
authors.lastname: Spampinato
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D004744:Enkephalin, Methionine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006985:Hyperventilation / Q000188:drug therapy*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D018847:Opioid Peptides / Q000494:pharmacology*; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood
chemical_list: D002395:Catecholamines; D018847:Opioid Peptides; D009270:Naloxone; D004744:Enkephalin, Methionine; D001615:beta-Endorphin