Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer.
A decade ago, chick-quail transplantation studies demonstrated that the junction between the midbrain and hindbrain has the properties of an organizing center capable of patterning the midbrain and cerebellum. Many of the genes that function to pattern these tissues have been identified and extensively studied. Recent experiments have shown that Otx2, Gbx2 and Fgf8 genes play a major role in the positioning and functioning of this organizing center.
Joyner
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Department of Cell Biology, NYU School of Medicine, 540 First Avenue, New York, New York 10016, USA. joyner@saturn.med.nyu.edu
Liu
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Millet
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D000818:Animals; D019521:Body Patterning / Q000235:genetics; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D002531:Cerebellum / Q000196:embryology / Q000378:metabolism; D004627:Embryonic Induction / Q000235:genetics; D005246:Feedback / Q000502:physiology; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D020897:Organizers, Embryonic / Q000378:metabolism*; D051857:Otx Transcription Factors; D016548:Prosencephalon / Q000196:embryology / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
C496457:Fgf8 protein, mouse; C513182:Gbx2 protein, mouse; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D051857:Otx Transcription Factors; C497660:Otx2 protein, mouse; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; C513181:gbx2 protein, zebrafish; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors