title: Rhabdomyolysis and aggravation of arthritis in a rheumatoid arthritis patient as a result of sepsis due to Staphylococcus aureus infection of a rheumatoid nodule; a catastrophic outcome.
abstract: A 63-year-old man with rheumatoid arthritis presented with rhabdomyolysis and intractable arthritis of acute onset. He was diagnosed to have sepsis due to Staphylococcus aureus infection through of an ulcerated rheumatoid nodule. Staphylococcus aureus isolated from pus in the ulcerated rheumatoid nodule and a blood sample obtained from the heart post-mortem produced the toxic shock syndrome toxin-1 (TSST-1). The TSST-1 and/or unmethylated CpG motifs in the oligonucleotides present in a bacterium, Staphylococcus aureus in this case, might be implicated in the induction of rhabdomyolysis and intractable arthritis.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima City, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Katakura
authors.forename: H
authors.initials: H
authors.lastname: Shishido
authors.forename: H
authors.initials: H
authors.lastname: Orikasa
authors.forename: O
authors.initials: O
authors.lastname: Munakata
authors.forename: M
authors.initials: M
authors.lastname: Saka
authors.forename: T
authors.initials: T
authors.lastname: Nishimaki
authors.forename: T
authors.initials: T
authors.lastname: Uchiyama
authors.forename: R
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000209:etiology*; D012218:Rheumatoid Nodule / Q000150:complications; D018805:Sepsis / Q000150:complications; D012772:Shock, Septic / Q000209:etiology; D013203:Staphylococcal Infections / Q000150:complications*; D014456:Ulcer / Q000150:complications