Novel antihyperglycemic terpenoid-quinones from Pycnanthus angolensis.
Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity.
Fort
D M
DM
Shaman Pharmaceuticals Inc., South San Francisco, California 94080-4812, USA. dfort@pharmanex.com
Ubillas
R P
RP
Mendez
C D
CD
Jolad
S D
SD
Inman
W D
WD
Carney
J R
JR
Chen
J L
JL
Ianiro
T T
TT
Hasbun
C
C
Bruening
R C
RC
Luo
J
J
Reed
M J
MJ
Iwu
M
M
Carlson
T J
TJ
King
S R
SR
Bierer
D E
DE
Cooper
R
R
D000349:Africa; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003920:Diabetes Mellitus / Q000097:blood / Q000235:genetics; D004435:Eating / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D001786:Blood Glucose; D005231:Fatty Acids, Unsaturated; D007004:Hypoglycemic Agents; D009285:Naphthoquinones; D010936:Plant Extracts; C416066:pycnanthuquinone A