The effects of some K(+) channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice.
The effects of three K(+) channel blockers, 4-aminopyridine, 3, 4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shock reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shock in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K(+) channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation.
Inan
S Y
SY
Department of Pharmacology, School of Medicine, University of Cukurova, 01330 Balcali, Adana, Turkey.
Aksu
F
F
Baysal
F
F
D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000077770:Amifampridine; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D004597:Electroshock; D008297:Male; D051379:Mice; D018727:Muscarinic Antagonists; D026902:Potassium Channel Blockers; D012153:Retention, Psychology / Q000187:drug effects* / Q000502:physiology; D012601:Scopolamine
D018727:Muscarinic Antagonists; D026902:Potassium Channel Blockers; D001030:Apamin; D015761:4-Aminopyridine; D012601:Scopolamine; D000077770:Amifampridine