Cutaneous Rosai-Dorfman disease--a pathologic review of 2 cases.
Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare but distinct clinicopathologic entity characterised histologically by a benign s histiocytic proliferation. Isolated involvement of extranodal sites without concomitant nodal disease is rare. We describe the pathological features of 2 cases of Rosai-Dorfman disease that were clinically confined to the skin. In both male adult Chinese patients, proliferation of histiocytes was accompanied by S-100 protein expression demonstrated immunohistochemically within the histiocytes. The pathology of Rosai-Dorfman disease and its microscopic differential diagnoses are discussed.
Chuah
K L
KL
Department of Pathology, Singapore General Hospital, Singapore.
Tan
P H
PH
Hwang
S G
SG
Ong
B H
BH
Chuan
K L
KL
D000328:Adult; D015618:Histiocytosis, Sinus / Q000473:pathology*; D006801:Humans; D008297:Male; D012867:Skin / Q000473:pathology*