title: Sex- and organ-specific toxicity in normal and malnourished rats fed thermoxidized palm oil.
abstract: The effects of free radical toxicity as induced by chronic consumption of thermoxidized palm oil (TPO) diet on organ size of normal animals, their first filial offspring and malnourished rats, were studied. Tissue- and sex-specific toxicity was revealed. The TPO diet significantly (P<0.01) reduced lung and kidney mass in normal male rats but female rats remained unaffected. Hearts of first filial offspring of both male and female rats were, however, enlarged while lung, liver and kidneys of first filial female offspring were additionally reduced in size (P<0.01). This information suggests that the observed toxicities could be cumulative for female offspring. Malnutrition protected against toxic injury because none of the kwashiorkoric animals rehabilitated on the toxic diet showed any overt symptoms of toxicity.
authors.affiliation: Dept of Chemistry and Biochemistry, University of Uyo, PMB 1017, Uyo - AKS, Nigeria. uisong@hotmail.com
authors.forename: E U
authors.initials: EU
authors.lastname: Isong
authors.forename: E U
authors.initials: EU
authors.lastname: Essien
authors.forename: O U
authors.initials: OU
authors.lastname: Eka
authors.forename: I B
authors.initials: IB
authors.lastname: Umoh
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced / Q000473:pathology; D004032:Diet; D005260:Female; D005609:Free Radicals / Q000633:toxicity; D006358:Hot Temperature; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007732:Kwashiorkor / Q000534:rehabilitation; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D000073878:Palm Oil; D010938:Plant Oils / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D012727:Sex Characteristics
chemical_list: D005609:Free Radicals; D010938:Plant Oils; D000073878:Palm Oil