title: Tamoxifen-induced severe hypertriglyceridemia and pancreatitis.
abstract: Tamoxifen exhibits favorable effects on the lipid and lipoprotein profile since it decreases the total and LDL cholesterol levels as well as the Lp(a) levels. Additionally, a small increase in serum triglycerides is commonly found after tamoxifen administration. However, severe hypertriglyceridemia which can sometimes be associated with life-threatening complications is occasionally noticed. Herein, we describe a patient who developed tamoxifen-induced severe hypertriglyceridemia and pancreatitis. An analysis of the underlying pathogenetic mechanisms as well as a review of the relevant literature is also provided.
authors.affiliation: Department of Internal Medicine, University of Ioannina, Medical School, Greece.
authors.forename: M S
authors.initials: MS
authors.lastname: Elisaf
authors.forename: K
authors.initials: K
authors.lastname: Nakou
authors.forename: G
authors.initials: G
authors.lastname: Liamis
authors.forename: N A
authors.initials: NA
authors.lastname: Pavlidis
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D015228:Hypertriglyceridemia / Q000139:chemically induced*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced*; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate