Fatal thrombotic thrombocytopenic purpura as a rare complication following allogeneic stem cell transplantation.
Thrombotic thrombocytopenic purpura (TTP) is a rare disease which, together with hemolytic uremic syndrome, is subsumed under thrombotic microangiopathy. After stem cell transplantation (SCT), this syndrome represents a possibly fatal complication with a higher incidence in allogeneic SCT than in autologous SCT. Although plasmapheresis offers an encouraging treatment modality in classic TTP, this seems less effective in bone marrow transplant-associated microangiopathy. This is probably due to a different etiology. We present a case of transplant-associated TTP with a fatal outcome despite multiple courses of plasmapheresis.
Chemnitz
J
J
I. Department of Medicine, University of Cologne, Köln, Germany. jens.chemnitz@uni-koeln.de
Fuchs
M
M
Blau
W
W
Hartmann
P
P
Wickenhauser
C
C
Scheid
C
C
Schulz
A
A
Diehl
V
V
Söhngen
D
D
D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010951:Plasma Exchange; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology* / Q000628:therapy; D014184:Transplantation, Homologous