[The characteristics of the effect of thyroxine on sphingosine and phosphoinositide synthesis in the rat liver in ontogeny].
The age peculiarities of sphingosine, phosphatidylinoside, phosphatidylinoside 4-phosphate and phosphatidylinoside 4,5-bisphosphate in liver and thyroxine influences on this processes has been investigated. It has been determined that sphingosine, phosphatidylinoside and phosphatidylinoside 4-phosphate synthesis in liver drop in old age. It was found that thyroxine enhances the labelled precursor incorporation into sphingosine of 3- and 24-old rat, and phosphatidylinoside 4,5-bisphosphate--24-old animals and decreases the synthesis of phosphatidylinoside and phosphatidylinoside 4-phosphate in liver of the young rats.
Krasil'nikova
O A
OA
Kharkov State University.
Natarova
Iu O
IuO
Babenko
N A
NA
D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010716:Phosphatidylinositols / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013110:Sphingosine / Q000032:analysis / Q000096:biosynthesis*; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors
D010716:Phosphatidylinositols; D013110:Sphingosine; D013974:Thyroxine