Gd-DTPA relaxivity depends on macromolecular content.
Gd-DTPA T(1) relaxivity of water protons was measured at 1.5 T and room temperature as a function of macromolecular content in model systems. Gd-DTPA relaxivity was found to increase with macromolecular concentration. The results of this study indicate that the Gd-DTPA relaxivity in tissue extracellular compartment could be as much as 30-70% higher than that of Gd-DTPA in saline. Quantitative MR analyses that use T(1) as an estimation of local Gd-DTPA concentration require a priori determination of the Gd relaxivity in tissue.
Stanisz
G J
GJ
Departments of Medical Biophysics and Imaging Research, Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. stanisz@srcl.sunnybrook.utoronto.ca
Henkelman
R M
RM
D000818:Animals; D002645:Chickens; D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism; D004527:Egg Proteins / Q000737:chemistry / Q000378:metabolism; D019786:Gadolinium DTPA / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging / Q000379:methods*
D003287:Contrast Media; D004527:Egg Proteins; D019786:Gadolinium DTPA