The effects of dopaminergic mediation upon colloidopectic activity of the mononuclear phagocyte system.
The investigations were carried out on 30 Wistar albino male rats. A group of animals received Levodpa (Nakom), another group received Methyldopa (Dopegyt). One and a half hour after administration, the phagocytic activity was measured using colloidal carbon. Subsequent to Levodopa administration a significant increase occurred in the phagocytic activity. Following the treatment with Methyldopa the phagocytic activity in macrophages decreased. Our studies confirm the idea that the central adrenergic system stimulates the colloidopectic capacity of macrophages.
Pop
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Department of Physiology, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania.
Dorofteiu
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Don
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D000818:Animals; D002244:Carbon; D003102:Colloids; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D008297:Male; D008750:Methyldopa / Q000494:pharmacology; D015213:Neuroimmunomodulation / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D013565:Sympatholytics / Q000494:pharmacology
D003102:Colloids; D015259:Dopamine Agents; D013565:Sympatholytics; D007980:Levodopa; D008750:Methyldopa; D002244:Carbon; D004298:Dopamine