title: [The treatment of laryngeal papillomatosis with interferon inducers].
abstract: Seventy three patients aged 16 to 88 years who had laryngeal papillomatosis (LP) were followed up. Microsurgical endolaryngeal removal of laryngeal papillomas was made in all the patients. The interferon inducers amixine and cycloferon as antirecurrent drugs were used in 45 patients by the regime the authors developed by taking into account the interferon status and cellular immunity of patients. The criteria for the efficiency of treatment were their improved interferon status and longer remission. The efficiency of treatment with amixine and cycloferon was 72 and 80%, respectively. Thus, the use of a sparing microsurgical intervention in combination with interferon inducers may be regarded as the method of choice in the LP treatment.
authors.forename: F S
authors.initials: FS
authors.lastname: Karimova
authors.forename: G F
authors.initials: GF
authors.lastname: Ivanchenko
authors.forename: S S
authors.initials: SS
authors.lastname: Grigorian
mesh_terms: D000166:Acridines / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007369:Interferon Inducers / Q000627:therapeutic use*; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D009367:Neoplasm Staging; D010212:Papilloma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D013994:Tilorone / Q000627:therapeutic use*
chemical_list: D000166:Acridines; D007369:Interferon Inducers; D013994:Tilorone; C026430:10-carboxymethyl-9-acridanone