B-cell leukemia in a rhesus macaque (Macaca mulatta) infected with simian immunodeficiency virus.
Conditions associated with abnormal B-cell proliferation have an increased incidence in the HIV-infected population. A longitudinal study conducted at the Tulane Regional Primate Research Center has followed more than 1,000 rhesus macaques infected with simian-immunodeficiency virus (SIV) since 1984. While spontaneous B-cell malignancy in SIV-negative macaques has not been reported, 42 cases of SIV-associated-lymphoma (SAL) have been documented in this cohort. Recently we identified a single case of B-cell leukemia, first suggested by clinical abnormalities and confirmed and further characterized by molecular analysis. The case is important because it models the occurrence of B-cell leukemia in the human AIDS patient and because it extends our understanding of the B-cell lymphoproliferative diseases associated with AIDS.
Fortgang
I S
IS
Department of Surgery, Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Didier
P J
PJ
Levy
L S
LS
D000818:Animals; D002999:Clone Cells / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006566:Herpesviridae Infections / Q000150:complications / Q000662:veterinary; D015448:Leukemia, B-Cell / Q000209:etiology / Q000662:veterinary*; D008137:Longitudinal Studies; D018143:Lymphocryptovirus / Q000302:isolation & purification; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000662:veterinary; D008253:Macaca mulatta / Q000821:virology*; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications; D016133:Polymerase Chain Reaction; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity*; D014412:Tumor Virus Infections / Q000150:complications / Q000662:veterinary
D004279:DNA, Viral