title: Postantibiotic leukocyte enhancement of meropenem against gram-positive and gram-negative strains.
abstract: The postantibiotic leukocyte enhancement (PALE) of meropenem in vitro in comparison with that of imipenem was evaluated with 24 recently isolated gram-positive and gram-negative strains. In general, pre-exposure to carbapenems (at four times the MIC for 2 h) led to increased polymorphonuclear cell phagocytic killing. The PALE of imipenem was generally significantly less than that observed with meropenem.
authors.affiliation: Dipartimento di Farmacologia Preclinica e Clinica, Università degli Studi di Firenze, Florence, Italy. novelli@server1.pharm.unifi.it
authors.forename: A
authors.initials: A
authors.lastname: Novelli
authors.forename: S
authors.initials: S
authors.lastname: Fallani
authors.forename: M I
authors.initials: MI
authors.lastname: Cassetta
authors.forename: S
authors.initials: S
authors.lastname: Conti
authors.forename: T
authors.initials: T
authors.lastname: Mazzei
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015780:Carbapenems / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000502:physiology; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D007962:Leukocytes / Q000502:physiology*; D000077731:Meropenem; D009504:Neutrophils / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem