title: [Conformational features of a pentapeptide as an element of the active center of human immunoglobulin E].
abstract: The spatial structures of human immunoglobulin E pentapeptide Asp-Ser-Asp-Pro-Arg and some of its related peptides were investigated by the method of theoretical conformational analysis. These synthetic peptides have the capacity to inhibit the binding of immunoglobulin E to the mast cells of the skin. The results of the calculations and the data on biological activity of these peptides were used for determination their energy-dependent conformational characteristics that provide their specific interaction with receptors of mast cells.
authors.affiliation: Rasulzade Baku State University, Azerbaijan.
authors.forename: N M
authors.initials: NM
authors.lastname: Godzhaev
authors.forename: G A
authors.initials: GA
authors.lastname: Agaeva
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D006801:Humans; D007073:Immunoglobulin E / Q000737:chemistry* / Q000378:metabolism; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D009842:Oligopeptides; D007073:Immunoglobulin E