title: Acute renal failure due to idiopathic tubulo-intestinal nephritis and uveitis: "TINU syndrome". Case report and review of the literature.
abstract: Acute renal failure due to idiopathic tubulo-interstitial nephritis associated with bilateral uveitis (TINU syndrome) is a rare clinical event, contracted mainly by girls or women. Here we report the clinical follow-up regarding a 22-year-old woman with acute renal failure (creat. clearance 13.5 ml/min) due to idiopathic tubulo-interstitial nephritis documented by renal biopsy, after bilateral uveitis which healed with local prednisone. The clinical history and the clinical follow-up of our patient were typical of the TINU syndrome. We were able to exclude all diseases causing acute tubulo-interstitial nephritis such as systemic infection, hypersensitivity to drugs, Behcet's disease, Sjogren syndrome, sarcoidosis, systemic lupus or vasculitides. The patient recovered after systemic prednisone.
authors.affiliation: Nephrology and Dialysis Unit, General Hospital, Vimercate, Italy. adsess@tin.it
authors.forename: A
authors.initials: A
authors.lastname: Sessa
authors.forename: M
authors.initials: M
authors.lastname: Meroni
authors.forename: G
authors.initials: G
authors.lastname: Battini
authors.forename: G
authors.initials: G
authors.lastname: Viganò
authors.forename: P L
authors.initials: PL
authors.lastname: Brambilla
authors.forename: C T
authors.initials: CT
authors.lastname: Paties
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*; D000328:Adult; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D009395:Nephritis, Interstitial / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D013577:Syndrome; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis