Visceral nociception.
Visceral pain is of great concern to the medical community because it remains particularly resistant to current clinical treatments. A serendipitous and initially unexplainable clinical finding that a punctate midline dorsal column lesion is effective in eliminating visceral pain, however, has initiated a resurgence of interest in the study of the basic mechanisms of visceral nociception. Clinical and anatomic findings have determined that visceral pain either of thoracic or pelvic origin can be relieved by carefully placed lesions directed at the lateral edge or the medial edge of the gracile fasciculus, respectively. Studies are demonstrating that visceral pain is quite unique from cutaneous pain.
Westlund
K N
KN
Department of Anatomy and Neurosciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA. kwhigh@utmb.edu
D000344:Afferent Pathways / Q000473:pathology / Q000503:physiopathology*; D001933:Brain Stem / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009619:Nociceptors / Q000378:metabolism*; D010146:Pain / Q000473:pathology* / Q000503:physiopathology*; D020671:Posterior Horn Cells / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology; D017833:Visceral Afferents / Q000473:pathology / Q000503:physiopathology*
D017981:Receptors, Neurotransmitter