title: Synthesis of functionalized cannabinoids.
abstract: An effective synthesis of tricyclic, nonclassical cannabinoids has been developed on the basis of a cation-olefin cyclization that forms the two nonaromatic rings with the desired stereochemistry in a single step.
authors.affiliation: Department of Chemistry, University of Hawaii, Honolulu 96822, USA.
authors.forename: P E
authors.initials: PE
authors.lastname: Harrington
authors.forename: I A
authors.initials: IA
authors.lastname: Stergiades
authors.forename: J
authors.initials: J
authors.lastname: Erickson
authors.forename: A
authors.initials: A
authors.lastname: Makriyannis
authors.forename: M A
authors.initials: MA
authors.lastname: Tius
mesh_terms: D000475:Alkenes; D000818:Animals; D001921:Brain / Q000378:metabolism; D002186:Cannabinoids / Q000138:chemical synthesis* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D007700:Kinetics; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D002186:Cannabinoids; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug