BRCA1: exploring the links to transcription.
Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and transcriptional regulation. Recent developments indicate that BRCA1 is a multifunctional protein, and disruption of its transcriptional activity could be crucial for tumor development.
Monteiro
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Dept of Cell Biology, Weill Medical College of Cornell University, New York, NY 10021, USA.
D019313:BRCA1 Protein / Q000235:genetics* / Q000378:metabolism*; D004260:DNA Repair; D006801:Humans; D012319:RNA Polymerase II / Q000378:metabolism*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D019313:BRCA1 Protein; D012319:RNA Polymerase II