Pharmacokinetics of rectal paracetamol after repeated dosing in children.
Twenty-three children (aged between 9 weeks and 11 yr) were given paracetamol suppositories 25 mg kg-1 every 6 h (maximum 5 days) after major surgery and serum and saliva concentrations were measured. There was a good correlation (r = 0.91, P < 0.05) between saliva and serum concentrations. A one-compartment linear model with first-order elimination and absorption and lag-time was fitted to the data (ADAPT II). At steady state, the mean (SD) concentration was 15.2 (6.8) mg litre-1. Mean (SD) time to reach 90% of the steady state concentration was 11.4 (8.6) h. Body weight, age and body surface area were well correlated (P < 0.05) with clearance and apparent volume of distribution. There was no evidence of accumulation leading to supratherapeutic concentrations during this dosing schedule for a mean of approximately 2-3 days.
Hahn
T W
TW
Department of Pharmaceutics, Royal Danish School of Pharmacy, Universitetsparken, Copenhagen, Denmark.
Henneberg
S W
SW
Holm-Knudsen
R J
RJ
Eriksen
K
K
Rasmussen
S N
SN
Rasmussen
M
M
D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000285:Administration, Rectal; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000886:Anthropometry; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008954:Models, Biological; D010149:Postoperative Pain / Q000097:blood / Q000517:prevention & control*; D012463:Saliva / Q000378:metabolism; D013488:Suppositories
D018712:Analgesics, Non-Narcotic; D013488:Suppositories; D000082:Acetaminophen