title: Normal values of regional left ventricular endocardial motion: multicenter color kinesis study.
abstract: Our goal was to establish normal values for quantitative color kinesis indexes of left ventricular (LV) wall motion over a wide range of ages, which are required for objective diagnosis of regional systolic and diastolic dysfunction. Color-encoded images were obtained in 194 normal subjects (95 males, 99 females, age 2 mo to 79 yr) in four standard views. Quantitative indexes of magnitude and timing of systolic and diastolic function were studied for age- and gender-related differences. Normal limits of all ejection and filling indexes were in a narrow range (< or =25% of the mean), with no major gender-related differences. Despite invariable ejection fractions, both peak filling and ejection rates decreased with age (30 and 20%, correspondingly) with a concomitant increase in mean filling and ejection times, resulting in five- and twofold increases in the late to early filling and ejection ratios, correspondingly. Diastolic asynchrony increased with age (from 4.7 +/- 2.0 to 6.4 +/- 3.2 from the 2nd to 7th decade). The normal values of color kinesis indexes should allow objective detection of regional LV systolic and diastolic dysfunction.
authors.affiliation: The University of Chicago, Chicago, Illinois 60637, USA. vmoravi@medicine.bsd.uchicago.edu
authors.forename: V
authors.initials: V
authors.lastname: Mor-Avi
authors.forename: K
authors.initials: K
authors.lastname: Spencer
authors.forename: J
authors.initials: J
authors.lastname: Gorcsan
authors.forename: A
authors.initials: A
authors.lastname: Demaria
authors.forename: T
authors.initials: T
authors.lastname: Kimball
authors.forename: M
authors.initials: M
authors.lastname: Monaghan
authors.forename: J
authors.initials: J
authors.lastname: Perez
authors.forename: J P
authors.initials: JP
authors.lastname: Sun
authors.forename: L
authors.initials: L
authors.lastname: Weinert
authors.forename: J
authors.initials: J
authors.lastname: Bednarz
authors.forename: K
authors.initials: K
authors.lastname: Collins
authors.forename: K
authors.initials: K
authors.lastname: Edelman
authors.forename: O L
authors.initials: OL
authors.lastname: Kwan
authors.forename: B
authors.initials: B
authors.lastname: Glascock
authors.forename: J
authors.initials: J
authors.lastname: Hancock
authors.forename: C
authors.initials: C
authors.lastname: Baumann
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Lang
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003971:Diastole / Q000502:physiology; D018618:Echocardiography, Doppler, Color; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D015588:Observer Variation; D012016:Reference Values; D015203:Reproducibility of Results; D017678:Sex Distribution; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*