Exemestane improves survival compared with megoestrol acetate in postmenopausal patients with advanced breast cancer who have failed on tamoxifen. results Of a double-blind randomised phase III trial.
Exemestane is an aromatase inactivator. 769 Postmenopausal women with advanced breast cancer who had failed on tamoxifen were randomised to exemestane or megoestrol acetate in this double-blind trial. Objective response rate was similar between treatments. Median time to progression, time to treatment failure and overall survival was significantly longer with exemestane. Drug-related withdrawals and drug-related deaths were more common with megoestrol acetate.
Kaufmann
M
M
Universitätsklinik, Goethe-Universität, 60596, Frankfurt, Germany. m.kaufmann@em.uni-frankfurt.de
Bajetta
E
E
Dirix
L Y
LY
Fein
L E
LE
Jones
S E
SE
Cervek
J
J
Fowst
C
C
Polli
A
A
Di Salle
E
E
Massimini
G
G
Piscitelli
G
G
D000730:Androstadienes / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004311:Double-Blind Method; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D019290:Megestrol Acetate / Q000627:therapeutic use*; D017698:Postmenopause; D016019:Survival Analysis; D013629:Tamoxifen / Q000627:therapeutic use*; D017211:Treatment Failure
D000730:Androstadienes; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D013629:Tamoxifen; C056516:exemestane; D019290:Megestrol Acetate