title: Adult cardiac surgery outcomes: role of the pump type.
abstract: OBJECTIVE
  This study was carried out to evaluate whether the type of pump used for cardiopulmonary bypass (CPB; roller vs. centrifugal) can affect mortality or the neurological outcomes of adult cardiac surgery patients.
  
  
  METHODS
  Between 1994 and June 1999, 4000 consecutive patients underwent coronary and/or valve surgery at our hospital; of these, 2213 (55.3%) underwent surgery with centrifugal pump use, while 1787 (44.7%) were operated on with a roller pump. The effect of the type of the pump and of 36 preoperative and intraoperative risk factors for perioperative death, permanent neurological deficit and coma were assessed using univariate and multivariate analyses.
  
  
  RESULTS
  The overall in-hospital mortality rate was 2.2% (88/4000), permanent neurological deficit occurred in 2.0% (81/4000) of patients, and coma in 1.3% (52/4000). There was no difference in hospital mortality between patients operated with the use of centrifugal pumps and those operated with roller pumps (50/2213 (2.3%) vs. 38/1787 (2.1%); P=0.86). On the other hand, patients who underwent surgery with centrifugal pumps had lower permanent neurological deficit (34/2213, (1.5%) vs. 47/1787 (2.6%); P=0.020) and coma (20/2213 (0.9%) vs. 32/1787 (1.8%); P=0.020) rates than patients operated with roller pumps. Multivariate analysis showed CPB time, previous TIA and age as risk factors for permanent neurological deficit, while centrifugal pump use emerged as protective. Multivariate risk factors for coma were CPB time, previous vascular surgery and age, while centrifugal pump use was protective.
  
  
  CONCLUSIONS
  Centrifugal pump use is associated with a reduced rate of major neurological complications in adult cardiac surgery, although this is not paralleled by a decrease in in-hospital mortality.
authors.affiliation: Department of Cardiac Surgery, University of Milan, Centro Cardiologico, Fondazione I Monzino IRCCS, Via Parea 4, 20138, Milan, Italy. aparolari@cardiologicomonzino.it
authors.forename: A
authors.initials: A
authors.lastname: Parolari
authors.forename: F
authors.initials: F
authors.lastname: Alamanni
authors.forename: M
authors.initials: M
authors.lastname: Naliato
authors.forename: R
authors.initials: R
authors.lastname: Spirito
authors.forename: V
authors.initials: V
authors.lastname: Franzè
authors.forename: G
authors.initials: G
authors.lastname: Pompilio
authors.forename: M
authors.initials: M
authors.lastname: Agrifoglio
authors.forename: P
authors.initials: P
authors.lastname: Biglioli
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001930:Brain Injuries / Q000209:etiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects* / Q000295:instrumentation* / Q000401:mortality; D003128:Coma / Q000209:etiology; D001026:Coronary Artery Bypass; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D017052:Hospital Mortality; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome