[Hypoxia and nitric oxide].
Cell death or survival under hypoxia is determined to a greater extent by the nature of changes in nitric oxide (NO) metabolism. Severe hypoxia causes NO overproduction that is an important factor that induces apoptotic cell death. In contrast, a cell response to moderate hypoxia enhances hypoxic resistance and restricts the mechanisms of activated apoptosis. A moderate increase in NO synthesis and storage that are characteristic of hypoxic adaptation may limit NO overproduction induced by acute hypoxia. In addition, NO-dependent mechanisms of adaptation are apparently involved in the restriction of apoptosis-specific signaling pathways. Therefore, during hypoxic adaptation, NO acts as an endogenous protective agent involved in the limitation of severe hypoxia-induced cell damages.
Malyshev
I Iu
IIu
Monastyrskaia
E A
EA
Smirin
B V
BV
Manukhina
E B
EB
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000378:metabolism* / Q000473:pathology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D015398:Signal Transduction
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase