title: A study of the inheritance of a bleeding disorder in Simmental cattle.
abstract: A study was designed to determine the inheritance pattern of a blood platelet aggregation disorder in Simmental cattle utilizing embryo transfer technology. A Simmental donor cow that had previously produced a calf with the platelet aggregation disorder was superovulated and mated to a bull that had also produced affected offspring. Twenty-seven calves were produced from the 63 (42.9%) embryos transferred. This somewhat lower than expected pregnancy rate is suggestive of an increased rate of embryo loss. Twenty-three of 25 (92%) calves had normal platelet aggregation patterns and 2 failed to show any evidence of platelet aggregation. Data are suggestive that inheritance is not simple Mendelian recessive. A more likely scenario is that the defect is the result of the inheritance of at least 2 genes, which is also consistent with the sporadic incidence reported in the population at large.
authors.affiliation: Department of Herd Medicine and Theriogenology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
authors.forename: R J
authors.initials: RJ
authors.lastname: Mapletoft
authors.forename: S M
authors.initials: SM
authors.lastname: Schmutz
authors.forename: G P
authors.initials: GP
authors.lastname: Searcy
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000235:genetics* / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D004624:Embryo Transfer / Q000662:veterinary*; D005260:Female; D010375:Pedigree; D010974:Platelet Aggregation / Q000235:genetics*; D011247:Pregnancy