title: Elevation of the gamma-aminobutyric acid transaminase expression in the gerbil CA1 area after ischemia-reperfusion damage.
abstract: gamma-Aminobutyric acid-transaminase (GABA-T) plays an important role in the metabolism of GABA, particularly in the neurons or glial cells. The present study was undertaken to determine the alteration of GABA-T expression in the gerbil hippocampus after ischemia-reperfusion. In the sham, GABA-T(+) neurons were scattered in the hippocampus proper and dentate gyrus. The intensity of the GABA-T immunoreactivity had nearly disappeared in the interneurons at 12 h after ischemia. In contrast, 24 h post-ischemia the dramatic augmentation of GABA-T immunoreactivity in the pyramidal cells was observed in the CA1 area but not in the CA2 or CA3 areas. Forty-eight hours after ischemia-reperfusion, its immunoreactivity was preserved in the CA1 neurons. These results suggest that the over-expression of GABA-T in the CA1 area may be related to delayed neuronal death after ischemia-reperfusion insult.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon, 200-702, Kangwon-Do, South Korea.
authors.forename: T C
authors.initials: TC
authors.lastname: Kang
authors.forename: S K
authors.initials: SK
authors.lastname: Park
authors.forename: J H
authors.initials: JH
authors.lastname: Bahn
authors.forename: J S
authors.initials: JS
authors.lastname: Chang
authors.forename: W S
authors.initials: WS
authors.lastname: Koh
authors.forename: S M
authors.initials: SM
authors.lastname: Jo
authors.forename: S W
authors.initials: SW
authors.lastname: Cho
authors.forename: S Y
authors.initials: SY
authors.lastname: Choi
authors.forename: M H
authors.initials: MH
authors.lastname: Won
mesh_terms: D000612:4-Aminobutyrate Transaminase / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D004195:Disease Models, Animal; D004591:Electrophoresis, Polyacrylamide Gel; D005849:Gerbillinae; D006624:Hippocampus / Q000201:enzymology* / Q000473:pathology; D007150:Immunohistochemistry; D007395:Interneurons / Q000201:enzymology / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000150:complications / Q000201:enzymology*; D008297:Male; D017966:Pyramidal Cells / Q000201:enzymology / Q000473:pathology; D015427:Reperfusion Injury / Q000201:enzymology* / Q000209:etiology
chemical_list: D000612:4-Aminobutyrate Transaminase