title: Maintenance of brain monoamine oxidase B inhibition in smokers after overnight cigarette abstinence.
abstract: OBJECTIVE
  The authors' goal was to replicate a previous finding that smokers have lower brain monoamine oxidase B (MAO-B) levels than comparison nonsmoking subjects and to determine if levels recover after overnight cigarette abstinence.
  
  
  METHODS
  Brain MAO-B levels were measured by means of positron emission tomography in six smokers who were scanned twice: 11.3 hours (baseline) and 10 minutes after smoking one cigarette.
  
  
  RESULTS
  Average MAO-B levels in smokers in the present study were similar to those found in the previous study and averaged 39% (SD=17) lower than those found in a comparison group of nonsmokers. Brain MAO-B levels did not differ between baseline levels and 10 minutes after smoking.
  
  
  CONCLUSIONS
  This study reinforces the need to investigate whether MAO-B inhibition may account for some of the behavioral and epidemiological features of smoking.
authors.affiliation: Brookhaven National Laboratory, Upton, NY 11973, USA. fowler@bnl.gov
authors.forename: J S
authors.initials: JS
authors.lastname: Fowler
authors.forename: G J
authors.initials: GJ
authors.lastname: Wang
authors.forename: N D
authors.initials: ND
authors.lastname: Volkow
authors.forename: D
authors.initials: D
authors.lastname: Franceschi
authors.forename: J
authors.initials: J
authors.lastname: Logan
authors.forename: N
authors.initials: N
authors.lastname: Pappas
authors.forename: C
authors.initials: C
authors.lastname: Shea
authors.forename: R R
authors.initials: RR
authors.lastname: MacGregor
authors.forename: V
authors.initials: V
authors.lastname: Garza
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D001921:Brain / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood / Q000378:metabolism*; D012907:Smoking / Q000097:blood / Q000378:metabolism* / Q000523:psychology; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000706:statistics & numerical data*
chemical_list: D015415:Biomarkers; D004791:Enzyme Inhibitors; D008995:Monoamine Oxidase