title: Glycosyltransferase structure and mechanism.
abstract: The high-resolution X-ray crystal structures of a new form of bacteriophage T4 beta-glucosyltransferase, Escherichia coli MurG, Bacillus subtilis SpsA, bovine beta-1,4-galactosyltransferase 1 and rabbit N-acetylglucosaminyltransferase I have now been solved. These glycosyltransferase structures have provided the first detailed view of the structural basis of catalysis, as well as new insight into glycosyltransferase classification.
authors.affiliation: Departments of Molecular and Medical Genetics and Biochemistry, University of Toronto, Ontario, M5S 1A8, Toronto, Canada.
authors.forename: U M
authors.initials: UM
authors.lastname: Unligil
authors.forename: J M
authors.initials: JM
authors.lastname: Rini
mesh_terms: D000818:Animals; D001665:Binding Sites; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D016695:Glycosyltransferases / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D016695:Glycosyltransferases