Acoustic droplet vaporization for therapeutic and diagnostic applications.
A phase shift droplet emulsion is introduced as an aid to unusual ultrasound (US) applications. The transpulmonary droplet emulsion (90% < 6 microm diameter) is made by mixing saline, bovine albumin and dodecafluoropentane. It has been observed that an acoustic pressure threshold exists, above which the droplets vaporize into bubbles approximately 25 times the original diameter. For frequencies between 1.5 and 8 MHz, the threshold decreases from 4.5 to 0.75 MPa peak rarefactional pressure. This paper presents preliminary results for droplet preparation and their evaporation as a function of applied acoustic pressure and frequency, as well as simulations of the lifetime of these gas bubbles based on gas diffusion. In vivo experiments were simulated by the evaporation of droplets in blood flowing under attenuating material. We propose that this agent might be useful for tissue occlusion in cancer treatment, as well as for phase aberration corrections in acoustic imaging.
Kripfgans
O D
OD
University of Michigan Health Systems, Department of Radiology, Ann Arbor, MI, USA.
Fowlkes
J B
JB
Miller
D L
DL
Eldevik
O P
OP
Carson
P L
PL
D000418:Albumins / Q000737:chemistry; D000818:Animals; D001769:Blood / Q000000981:diagnostic imaging; D002417:Cattle; D016461:Chemoembolization, Therapeutic / Q000379:methods; D003287:Contrast Media / Q000737:chemistry*; D004285:Dogs; D004655:Emulsions / Q000737:chemistry; D005466:Fluorocarbons / Q000737:chemistry*; D006801:Humans; D016018:Least-Squares Analysis; D009369:Neoplasms / Q000628:therapy; D012965:Sodium Chloride / Q000737:chemistry; D014465:Ultrasonics; D014463:Ultrasonography; D010420:Pentanes
D000418:Albumins; D003287:Contrast Media; D004655:Emulsions; D005466:Fluorocarbons; D012965:Sodium Chloride; C008806:perfluoropentane; D010420:Pentanes