Progesterone receptor activation. an alternative to SERMs in breast cancer.
Data regarding the effects of progesterone and a progestagen on human normal breast epithelial cell proliferation and apoptosis are presented here. In postmenopausal women, adding progesterone to percutaneously administrated oestradiol significantly reduces the proliferation induced by oestradiol. In vitro and in premenopausal women, stopping the administration of nomegestrol acetate triggers a peak of apoptosis. Fibro-adenoma and cancerous cells do not show this regulation of apoptosis. Progesterone seems to be important in normal breast homeostasis.
Desreux
J
J
Laboratory of Tumor and Development Biology, Tour de Pathologie +3 (B23), Sart-Tilman, B4000, Liège, Belgique. joelle.desreux@chu.ulg.ac.be
Kebers
F
F
Noël
A
A
Francart
D
D
Van Cauwenberge
H
H
Heinen
V
V
Thomas
J L
JL
Bernard
A M
AM
Paris
J
J
Delansorne
R
R
Foidart
J M
JM
D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006801:Humans; D011980:Receptors, Progesterone / Q000378:metabolism / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*
D011980:Receptors, Progesterone; D020845:Selective Estrogen Receptor Modulators