title: Birth insult alters dopamine-mediated behavior in a precocial species, the guinea pig. Implications for schizophrenia.
abstract: Schizophrenia is associated with increased birth complications, suggesting that birth complications might alter CNS dopaminergic activity later in life. In rats, Caesarean section (C-section) birth can produce long term changes in dopaminergic biochemistry and behavior. However rat brain is somewhat immature compared to human brain at birth. The current study tested if mild birth complications also alter dopamine-mediated function in a species with a more mature CNS at birth, the guinea pig. As adults, guinea pigs born by C-section showed increased amphetamine-induced locomotion and disruption of prepulse inhibition (PPI) of acoustic startle, compared to vaginally born controls. Guinea pigs born by C-section with 1 min of added global anoxia showed reduced amphetamine-induced locomotion and disrupted PPI, while a C-section plus 2 min anoxia group showed no change in amphetamine-induced locomotion but increased amphetamine-induced startle. No group differences in effects of amphetamine or apomorphine on PPI were observed. Taken with previous findings, these results indicate that mild birth complications can cause long term changes in dopamine-mediated behavior in both guinea pig and rat, two species spanning the level of human brain maturity at birth.
authors.affiliation: Departments of Psychiatry and of Neurology and Neurosurgery, McGill University, Douglas Hospital Research Centre,., Montreal, Quebec, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Vaillancourt
authors.forename: P
authors.initials: P
authors.lastname: Boksa
mesh_terms: D000367:Age Factors; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001238:Asphyxia Neonatorum / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D002585:Cesarean Section / Q000009:adverse effects; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D007231:Infant, Newborn; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine