title: Reduction in pain associated with open carpal tunnel decompression.
abstract: Patients treated by open carpal tunnel decompression under local anaesthetic experience significant pain with the introduction of local anaesthetic before operation. A prospective double-blind randomized placebo controlled trial was carried out to assess whether this pain could be reduced with the pre-application of a topical lignocaine-prilocaine anaesthetic cream. Nineteen patients undergoing simultaneous bilateral operations were studied. Pain, measured with a visual analogue scale, was significantly reduced on the sides treated with anaesthetic cream. On a four point verbal scale the rating on the placebo side was "moderate" or "severe", compared to "mild" on the anaesthetic cream side. The reduction in pain was greater in women, possibly due to a relatively thinner dermis. There were no adverse effects.
authors.affiliation: Orthopaedic Department, Norfolk and Norwich NHS Healthcare Trust, Norwich, UK.
authors.forename: K
authors.initials: K
authors.lastname: Avramidis
authors.forename: J C
authors.initials: JC
authors.lastname: Lewis
authors.forename: P
authors.initials: P
authors.lastname: Gallagher
mesh_terms: D000779:Anesthetics, Local; D002349:Carpal Tunnel Syndrome / Q000601:surgery*; D019299:Decompression, Surgical; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008012:Lidocaine; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D009824:Ointments; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D011318:Prilocaine; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D008012:Lidocaine