Peritoneal carcinomatosis in germ-cell tumor: relations with retroperitoneal lymph node dissection.
Peritoneal carcinomatosis from germ-cell tumor has rarely been described, and thus remains largely unknown. We report here five cases involving this entity. All five patients had embryonal carcinoma in their primary germ-cell tumor. Four of them had undergone retroperitoneal lymph node dissection (RPLND), and viable malignant cells were found. RPLND was performed for relapses (n = 3) and as primary therapy for stage II disease (n = 1). The peritoneum was the only site of relapse in three patients, and was associated with pleural effusion in one. The time to relapse after RPLND ranged from 6 to 14 months. One patient sustained injury to lymph nodes during RPLND, and another patient had a peritoneal xanthelasma. The only three patients already described in the literature underwent RPLND or surgical biopsy. All these observations suggest a striking relation between RPLND and occurrence of subsequent peritoneal carcinomatosis.
Andre
F
F
Department of Medicine, Institut Gustave-Roussy, Villejuif, France.
Fizazi
K
K
Culine
S
S
Droz
J P
JP
Gatineau
M
M
Takahashi
Y
Y
Oudard
S
S
Theodore
C
C
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018236:Carcinoma, Embryonal / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008197:Lymph Node Excision; D008297:Male; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000556:secondary*; D012187:Retroperitoneal Space; D018239:Seminoma / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery
D000970:Antineoplastic Agents