[Effects of yizhi pills on memory, superoxide dismutase and malondialdehyde of brain and immunity in mice].
Passive avoidance tests have shown that Yizhi Pills (YZ) markedly improve the memory of normal mice at a dose of 100 mg/kg after oral administration for fifteen days, and significantly reverse the scopolamine, NaNO2 and EtOH-induced disruptions of memory retention in mice at doses of 100, 200, 500 mg/kg after oral administration for five days. In aged mice induced by D-galactose, YZ also significantly improve the impaired memory, increase the activity of SOD and decrease the content of MDA in brain. All these effects were observed at doses of 200, 500 mg/kg after oral administration for forty-one days. YZ significantly promote blood carbon particle clearance, enhance hemolysin antibody in immunodepressed mice induced by cyclophosphamide, and increase earswelling in immunodepressed mice induced by prednisolonum.
Kou
J
J
Institute of Chinese Materia Medica, China Pharmaceutical University, Nanjing.
Yu
Z
Z
Tian
J
J
Ma
S
S
Yan
Y
Y
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006460:Hemolysin Proteins / Q000276:immunology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D008813:Mice, Inbred ICR; D013482:Superoxide Dismutase / Q000378:metabolism*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins; D008315:Malondialdehyde; D013482:Superoxide Dismutase