Normal telomere lengths found in cloned cattle.
Success of cloning using adult somatic cells has been reported in sheep, mice and cattle. The report that 'Dolly' the sheep, the first clone from an adult mammal, inherited shortened telomeres from her cell donor and that her telomeres were further shortened by the brief culture of donor cells has raised serious scientific and public concerns about the 'genetic age' and potential developmental problems of cloned animals. This observation was challenged by a recent report that showed calves cloned from fetal cells have longer telomeres than their age-matched controls. The question remains whether Dolly's short telomeres were an exception or a general fact, which would differ from the telomeres of fetal-derived clones.
Tian
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Department of Animal Science and the Biotechnology Center, University of Connecticut, Storrs, Connecticut USA.
Xu
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Yang
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D000375:Aging / Q000235:genetics; D000818:Animals; D002417:Cattle / Q000235:genetics*; D016922:Cellular Senescence / Q000235:genetics; D019976:Cloning, Organism; D005260:Female; D008136:Longevity / Q000235:genetics; D012756:Sheep / Q000235:genetics; D013045:Species Specificity; D016615:Telomere / Q000648:ultrastructure*