Decoding calcium signals involved in cardiac growth and function.
Calcium is central in the regulation of cardiac contractility, growth and gene expression. Variations in the amplitude, frequency and compartmentalization of calcium signals are decoded by calcium/calmodulin-dependent enzymes, ion channels and transcription factors. Understanding the circuitry for calcium signaling creates opportunities for pharmacological modification of cardiac function.
Frey
N
N
Department of Molecular Biology, The University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.
McKinsey
T A
TA
Olson
E N
EN
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology; D006332:Cardiomegaly / Q000503:physiopathology; D005786:Gene Expression Regulation; D006321:Heart / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*
D002147:Calmodulin