Cholic acid is accumulated spontaneously, driven by membrane deltapH, in many lactobacilli.
Many lactobacilli from various origins were found to apparently lack cholic acid extrusion activity. Cholic acid was accumulated spontaneously, driven by the transmembrane proton gradient. Accumulation is a newly identified kind of interaction between intestinal microbes and unconjugated bile acids and is different from extrusion and modification, which have been described previously.
Kurdi
P
P
Laboratory of Applied Microbiology, Research Group of Molecular Bioscience, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
van Veen
H W
HW
Tanaka
H
H
Mierau
I
I
Konings
W N
WN
Tannock
G W
GW
Tomita
F
F
Yokota
A
A
D001692:Biological Transport; D019826:Cholic Acid / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007778:Lactobacillus / Q000378:metabolism*
D019826:Cholic Acid