title: Comparison of MRI and MRA findings in children with a variety of neurologic conditions.
abstract: The role of MRA in the evaluation of children is evolving. We compared MRA and MRI in children with a variety of neurologic conditions to determine when MRA provides positive, cost-beneficial information. A total of 114 patients were retrospectively studied. MRA and MRI were performed and compared. MRA was abnormal in 34 (30%) of 114 patients: five (83%) of six with Menkes' disease, four (33%) of 12 with sickle cell disease, 12 (38%) of 32 with vascular malformations, one (6%) of 17 with headaches, seven (24%) of 24 with new focal deficits, one (10%) of 10 with seizures, and four (31%) of 13 with miscellaneous diagnoses. MRA and MRI were concordant in 73 (64%) of 114. Maximum concordance was in patients with Menkes' disease (100%) and minimum in those with new focal deficits (50%). The best MRA cost/benefit ratios were obtained in patients with Menkes' disease, vascular malformations, and sickle cell disease. A normal MRI usually forecasted a normal MRA. However, abnormal MRI findings did not always predict MRA abnormalities. Positive, cost-beneficial information is provided by MRA mostly in conditions known to involve the cerebral vasculature. Indications to perform MRA should be based on the neurologic diagnosis and MRI findings.
authors.affiliation: Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Husain
authors.forename: E
authors.initials: E
authors.lastname: Smergel
authors.forename: A
authors.initials: A
authors.lastname: Legido
authors.forename: E N
authors.initials: EN
authors.lastname: Faerber
authors.forename: C M
authors.initials: CM
authors.lastname: Foley
authors.forename: D K
authors.initials: DK
authors.lastname: Miles
authors.forename: W D
authors.initials: WD
authors.lastname: Grover
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003362:Cost-Benefit Analysis / Q000191:economics; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018810:Magnetic Resonance Angiography / Q000191:economics; D008279:Magnetic Resonance Imaging / Q000191:economics*; D008297:Male; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000191:economics; D012189:Retrospective Studies