Rapid onset retinopathy in a diabetic patient following bone marrow transplantation.
We report a 38-year-old man who presented in 1998 with advanced multiple myeloma and newly diagnosed diabetes mellitus (DM). Subsequent BMT has been successful after conditioning with melphalan and total body irradiation, but significant ischaemic retinopathy has developed. Chemotherapeutic agents, total body irradiation, and DM are likely to have been co-factors in precipitating the rapid onset of retinopathy. Routine ophthalmic surveillance is recommended for all patients after BMT, particularly for those with additional risk factors for the development of retinopathy such as DM.
Gray
R H
RH
Taunton and Somerset NHS Trust, Somerset, UK.
Tighe
M
M
Russell
N H
NH
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D016026:Bone Marrow Transplantation; D048909:Diabetes Complications; D003930:Diabetic Retinopathy / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications / Q000628:therapy; D011183:Postoperative Complications / Q000139:chemically induced / Q000209:etiology*; D011832:Radiation Injuries / Q000209:etiology; D014916:Whole-Body Irradiation / Q000009:adverse effects
D000970:Antineoplastic Agents