title: A case of Guillain-Barré syndrome following a family outbreak of Campylobacter jejuni enteritis.
abstract: We describe an outbreak of Campylobacter jejuni enteritis involving three family members of whom one developed Guillain-Barré syndrome (GBS). The patients' serum reacted strongly with several gangliosides and with the lipopolysaccharide (LPS) fractions from the C. jejuni strains isolated from his family members. Only low titer anti-ganglioside antibodies were found in his siblings. HLA-typing did not indicate a locus associated with auto-antibody production. Comparing the immune response in GBS patients and C. jejuni enteritis patients can be of great value in determining the additional factors that lead to post-Campylobacter GBS. Ganglioside mimicry alone is necessary but not sufficient for the induction of anti-ganglioside antibodies. Other susceptibility factors are required to induce an anti-neural immune response.
authors.affiliation: Department of Neurology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands. ANG@neuro.fgg.eur.nl
authors.forename: C W
authors.initials: CW
authors.lastname: Ang
authors.forename: P A
authors.initials: PA
authors.lastname: van Doorn
authors.forename: H P
authors.initials: HP
authors.lastname: Endtz
authors.forename: I S
authors.initials: IS
authors.lastname: Merkies
authors.forename: B C
authors.initials: BC
authors.lastname: Jacobs
authors.forename: M A
authors.initials: MA
authors.lastname: de Klerk
authors.forename: R
authors.initials: R
authors.lastname: van Koningsveld
authors.forename: F G
authors.initials: FG
authors.lastname: van der Meché
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology; D002169:Campylobacter Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D016123:Campylobacter jejuni; D002648:Child; D004196:Disease Outbreaks; D004751:Enteritis / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D005192:Family Health; D005260:Female; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000276:immunology* / Q000382:microbiology*; D006650:Histocompatibility Testing; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008070:Lipopolysaccharides; D008297:Male; D018716:Molecular Mimicry
chemical_list: D000907:Antibodies, Bacterial; D005732:Gangliosides; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides