[Ca(2+)-signaling in peritoneal macrophages].
Mechanisms of the Ca2+ signal generation and regulation in peritoneal macrophages activated with purinergic agonists (ATP, UTP), as well as endoplasmic Ca(2+)-ATPase inhibitors, were investigated. Using a wide range of drugs affecting the intracellular signaling systems' components, an important role of second messenger systems and other key functional cellular systems in Ca2+ signals regulation in the macrophages, was shown.
Krutetskaia
Z I
ZI
St. Petersburg State University, Russia.
Lebedev
O E
OE
Krutetskaia
N I
NI
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D004721:Endoplasmic Reticulum / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology; D058913:Purinergic Agonists; D051381:Rats; D019284:Thapsigargin / Q000494:pharmacology; D014443:Tyrosine / Q000378:metabolism; D014544:Uridine Triphosphate / Q000494:pharmacology
D004791:Enzyme Inhibitors; D007211:Indoles; D058913:Purinergic Agonists; D016718:Arachidonic Acid; D014443:Tyrosine; D019284:Thapsigargin; D000255:Adenosine Triphosphate; D011493:Protein Kinase C; D000252:Calcium-Transporting ATPases; D002118:Calcium; D014544:Uridine Triphosphate; C000543:cyclopiazonic acid