title: Progression of an orbital T-cell rich B-cell lymphoma to a B-cell lymphoma in a dog.
abstract: An 11-year-old Shetland Sheepdog was presented for exophthalmos caused by a locally extensive, poorly defined mass located behind the right eye. The primary orbital mass was identified by light microscopy and immunohistochemistry as a T-cell rich B-cell lymphoma (TCRBCL) composed predominantly of BLA.36-positive large neoplastic lymphoid cells admixed with fewer CD3- and CD79a-positive small lymphocytes. The dog was treated for lymphoma, but 6 months after presentation it was euthanatized for suspected hepatic and gastrointestinal metastasis. Gross findings revealed an enlarged liver with multiple well-demarcated, randomly distributed 0.1-1.5-cm white nodules, five firm white submucosal jejunal nodules, and ileocecal, mediastinal, and hilar lymphadenopathy. Metastatic liver lesions consisted of sheets of monomorphic large neoplastic lymphoid cells that effaced and expanded portal and centrilobular zones. These cells were morphologically similar to the large neoplastic cells of the original orbital tumor and were CD3-negative and variably BLA.36-positive, consistent with B-cell lineage. Similar cells comprised the jejunal nodules and effaced the lymph nodes. The progression of TCRBCL to a diffuse B-cell lymphoma in this case is consistent with reported human cases and has not been previously reported in the dog.
authors.forename: S M
authors.initials: SM
authors.lastname: Aquino
authors.forename: R E
authors.initials: RE
authors.lastname: Hamor
authors.forename: V E
authors.initials: VE
authors.lastname: Valli
authors.forename: B E
authors.initials: BE
authors.lastname: Kitchell
authors.forename: S S
authors.initials: SS
authors.lastname: Tunev
authors.forename: K L
authors.initials: KL
authors.lastname: Bailey
authors.forename: E J
authors.initials: EJ
authors.lastname: Ehrhart
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D051925:CD79 Antigens; D018450:Disease Progression; D004283:Dog Diseases / Q000209:etiology / Q000473:pathology*; D004285:Dogs; D005065:Euthanasia / Q000662:veterinary; D005094:Exophthalmos / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D016130:Immunophenotyping / Q000662:veterinary; D007414:Intestinal Neoplasms / Q000556:secondary / Q000662:veterinary; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000556:secondary / Q000662:veterinary; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000662:veterinary*; D009918:Orbital Neoplasms / Q000473:pathology / Q000662:veterinary*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D013601:T-Lymphocytes / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D017252:CD3 Complex; D051925:CD79 Antigens; D011947:Receptors, Antigen, B-Cell