[Molecular medicine: new tools for better understanding and treatment of diseases in humans].
The authors discuss the importance that molecular medicine has assumed in recent years. Molecular methodologies have clearly demonstrated that immunological diversity is based fundamentally on the rearrangement of the genes encoding antigen B and T cell receptors. The importance of oncogenes, and their translocation in tumoral pathologies is emphasized, a case in point being the alterations observed in chronic myeloid leukemia and acute promyelocytic leukemia and their implication for innovative therapy. The importance of prothrombin and factor V genetic-molecular alterations in thromboembolic pathology and of the activation of calcineurin phosphatase or other intracellular signal regulator molecules during cardiac insufficiency genesis is also discussed. Particular attention is paid to progress regarding the socially important Alzheimer's syndrome, and the diagnosis of endocrine tumors. Moreover, the authors believe that the identification of new endocrine nuclear receptors, "orphans" of hormonal ligands, will open up interesting prospects--even therapeutic--in endocrinology. The authors conclude by reviewing the therapeutic prospects for immunodeficiency syndromes and malignant tumors, offered by new gene therapy methodologies. They also discuss recent results of studies on the aging process which, until not many years ago, appeared adventuristic. Today they are opening prospects of great interest.
Bonati
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Istituto di Patologia Speciale Medica, Università degli Studi di Parma.
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D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics; D000328:Adult; D000375:Aging / Q000235:genetics; D000544:Alzheimer Disease / Q000235:genetics; D002318:Cardiovascular Diseases / Q000235:genetics; D002493:Central Nervous System Diseases / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D004700:Endocrine System Diseases / Q000235:genetics; D015316:Genetic Therapy; D005826:Genetics, Medical; D015658:HIV Infections / Q000235:genetics; D006526:Hepatitis C / Q000235:genetics; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000628:therapy; D012106:Research; D013923:Thromboembolism / Q000235:genetics; D014158:Transcription, Genetic; D014178:Translocation, Genetic
D004273:DNA, Neoplasm