title: A comparison of the effects on postoperative pain relief of epidural analgesia started before or after surgery.
abstract: In a randomized, prospective clinical study pain relief and pulmonary function were compared after upper abdominal surgery when thoracic epidural analgesia was instituted either before or after surgery. Twenty-six patients admitted for surgery to treat gastro-oesophageal reflux received thoracic epidural analgesia as an adjunct to general anaesthesia either before or after surgery. Twelve patients received epidural mepivacaine 20 mg mL(-1) and morphine perioperatively. Another 14 patients received an epidural bolus of bupivacaine 2.5 mg mL(-1) and morphine after skin closure. Bupivacaine 2.5 mg mL(-1) with morphine was adminstered to all patients for three postoperative days. No intergroup differences were found regarding pain at rest and mobilization. The requirement for additional analgesics was similar in both groups as well as peak expiratory flow. Thoracic epidural analgesia that had already been induced before surgery, and was continued into the postoperative period, does not seem to add any advantage regarding pain relief and lung function compared with thoracic epidural analgesia instituted in the immediate postoperative period.
authors.affiliation: Department of Anesthesiology and Intensive Care, Lund University Hospital, Lund, SE-221 85 Lund, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Flisberg
authors.forename: K
authors.initials: K
authors.lastname: Törnebrandt
authors.forename: B
authors.initials: B
authors.lastname: Walther
authors.forename: J
authors.initials: J
authors.lastname: Lundberg
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015360:Analgesia, Epidural; D000701:Analgesics, Opioid; D000768:Anesthesia, General; D000779:Anesthetics, Local; D005260:Female; D006801:Humans; D008297:Male; D008619:Mepivacaine; D008875:Middle Aged; D009020:Morphine; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control / Q000628:therapy*; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies; D012123:Pulmonary Ventilation
chemical_list: D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D009020:Morphine; D008619:Mepivacaine