Expression and localization of prohormone convertase 1/3 (SPC3) in porcine ovary.
Tissue distribution and cellular localization of PC1/3 mRNA in porcine tissues were examined by ribonuclease protection assay and in situ hybridization. PC1/3 mRNA was detected mainly in the corpus luteum of pregnant sow and brain. Within the ovary, PC1/3 and relaxin transcripts colocalized within large luteal cells. Levels of PC1/3 transcripts in corpora lutea increased as gestation advanced, parallel with an observed increase in relaxin transcripts. A role for PC1/3 in proprotein processing in the ovary is discussed.
Renegar
R H
RH
Department of Anatomy and Cell Biology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA.
Owens
C R
CR
Dai
G
G
McMurtry
J P
JP
Kwok
S C
SC
D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D010053:Ovary / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D043484:Proprotein Convertases; D013552:Swine; D014018:Tissue Distribution
D043484:Proprotein Convertases; D016282:Aspartic Acid Endopeptidases