[Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene].
OBJECTIVE
To determine the loss of heterozygosity (LOH) on 9p21 (locus D9S1747) in patients with renal carcinoma by analysis of microsatellite polymorphisms.


METHODS
40 patients with sporadic renal cancer were studied. LOH on 9p21 was performed by analysis of microsatellite polymorphisms.


RESULTS
23.7% showed LOH on 9p21. No correlation was found between this genetic alteration and tumor features.


CONCLUSIONS
LOH on 9p21 was found in 23.7% of the patients in this series. LOH was found in 26.9% of renal cell carcinomas, 25% of papillary carcinomas and 25% of Bellini duct carcinomas. LOH was not found in the other histological types.
Maestro de las Casas
M L
ML
Servicio de Análisis Clínicos, Hospital Universitario San Carlos, Madrid.
Sanz-Casla
M T
MT
del Barco
V
V
Moreno
J
J
Zanna
I
I
Redondo
E
E
Fernández
C
C
Izquierdo
L
L
Resel Estévez
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000235:genetics*; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D019942:Genes, p16 / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011110:Polymorphism, Genetic