[Phosphinic analog of methionine inhibits growth of leucosis cell L1210 and transforms to phosphinic analog of S-adenosylmethionine].
A phosphinic analogue of methionine bearing a phosphinic H(OH)(O)P fragment in place of the carboxyl group inhibited the growth of the L1210 cells and was intracellularly transformed to the phosphinic analogue of S-adenosylmethionine.
Khomutov
R M
RM
Zhukov
Iu N
IuN
Khomutov
A R
AR
Khurs
E N
EN
Kramer
D L
DL
Miller
J T
JT
Porter
C W
CW
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D007939:Leukemia L1210 / Q000378:metabolism / Q000473:pathology; D008715:Methionine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D010721:Phosphinic Acids / Q000378:metabolism / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
C415425:1-amino-3-(methyl-(5'-deoxy-5'-adenosyl)thio)propylphosphinic acid; C415423:1-amino-3-(methylthio)propylphosphinic acid; D000970:Antineoplastic Agents; D010721:Phosphinic Acids; D008715:Methionine