title: Myorelaxant and antispasmodic effects of the essential oil of Alpinia speciosa on rat ileum.
abstract: The effects of the essential oil of Alpinia speciosa Schum (EOAS) on rat ileum were studied. EOAS (0.1-600 microg/mL) reversibly relaxed ileal basal tonus. Submaximal contractions induced by 60 mM KCl or acetylcholine were concentration dependently inhibited by EOAS with similar IC(50) values ( approximately 44 and 48 microg/mL, respectively). These results show that EOAS possesses both relaxant and antispasmodic actions in the ileum.
authors.affiliation: Centro de Ciências da Saúde, Universidade Vale do Acaraú, 850 Avenida da Universidade, Campus da Betânia, CEP 62.040-370, Sobral, CE, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Bezerra
authors.forename: J H
authors.initials: JH
authors.lastname: Leal-Cardoso
authors.forename: A N
authors.initials: AN
authors.lastname: Coelho-De-Souza
authors.forename: D N
authors.initials: DN
authors.lastname: Criddle
authors.forename: M C
authors.initials: MC
authors.lastname: Fonteles
mesh_terms: D000818:Animals; D007082:Ileum / Q000187:drug effects*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009822:Oils, Volatile / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D019862:Zingiberales
chemical_list: D009822:Oils, Volatile; D010276:Parasympatholytics; D010938:Plant Oils