title: Pathologic findings in late endophthalmitis after glaucoma filtering surgery.
abstract: OBJECTIVE
  To report the clinicopathologic features of four eyes enucleated for late-onset bleb-related endophthalmitis.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Four enucleated eyes.
  
  
  METHODS
  The clinical and histopathologic features of four patients who underwent enucleation for late-onset endophthalmitis after glaucoma filtering surgery were reviewed.
  
  
  RESULTS
  The eyes were enucleated for endophthalmitis one to five years after trabeculectomy. Two of the four eyes had trabeculectomy with adjunctive mitomycin-C. All four eyes had streptococci cultured from the aqueous and/or vitreous. Common pathologic features included inflammation involving the anterior segment, lens and choroid. One eye exhibited focal granulomatous uveitis.
  
  
  CONCLUSIONS
  Late-onset endophthalmitis after glaucoma filtering surgery is often due to streptococcal species and rapidly progresses over a few days. Phacoanaphylaxis with associated granulomatous uveitis may contribute to the poor prognosis in this setting.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Beck
authors.forename: H E
authors.initials: HE
authors.lastname: Grossniklaus
authors.forename: B
authors.initials: B
authors.lastname: Hubbard
authors.forename: D
authors.initials: D
authors.lastname: Saperstein
authors.forename: C L
authors.initials: CL
authors.lastname: Haupert
authors.forename: C E
authors.initials: CE
authors.lastname: Margo
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000382:microbiology; D009877:Endophthalmitis / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D015353:Eye Enucleation; D015818:Eye Infections, Bacterial / Q000209:etiology / Q000473:pathology / Q000601:surgery; D005260:Female; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D013291:Streptococcus / Q000302:isolation & purification; D014130:Trabeculectomy / Q000009:adverse effects*; D014822:Vitreous Body / Q000382:microbiology