Hypothetical 92.3-kD human protein homologous to angiotensin-converting enzyme: a new member of the zinc metalloprotease family?
Significant identity between a hypothetical 92.3-kD human protein and angiotensin-converting enzyme (ACE; peptidyl-dipeptidase A; kininase II) has been found. Certain specific regions of the 92.3-kD protein indicate that this unidentified molecule may be a member of the zinc metalloprotease family. A method is suggested for determination of a structural and functional family of proteins with unknown structure and function.
Buchatskii
A G
AG
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.
Kazachenko
K Y
KY
Alexandrov
A A
AA
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000737:chemistry*; D017433:Protein Structure, Secondary; D017386:Sequence Homology, Amino Acid; D015032:Zinc
D007703:Peptidyl-Dipeptidase A; D008666:Metalloendopeptidases; D015032:Zinc