Phase I and pharmacological study of increased dose oral topotecan in combination with intravenous cisplatin.
Gelderblom
A J
AJ
Department of Medical Oncology, Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and University Hospital Rotterdam, The Netherlands. gelderblom@onch.azr.nl
Loos
W J
WJ
de Jonge
M J
MJ
Sparreboom
A
A
Planting
A S
AS
van der Burg
M E
ME
Brouwer
E
E
Verheij
C
C
Ouwens
L
L
Hearn
S
S
Verweij
J
J
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D019772:Topotecan / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics
D019772:Topotecan; D002945:Cisplatin