Insulin secretion as a potential determinant of homocysteine levels.
The recently reported association between insulin resistance and elevated plasma homocyst(e)ine may reflect the fact that hyperinsulinemia suppresses hepatocyte expression of cystathionine beta-synthase, as demonstrated in rats. Thus, other measures which enhance diurnal insulin secretion - such as a high-glycemic-index diet - can be expected to increase homocysteine levels.
McCarty
M F
MF
Pantox Laboratories, San Diego, California 92109, USA.
D000818:Animals; D003541:Cystathionine beta-Synthase / Q000378:metabolism; D022781:Hepatocytes / Q000201:enzymology; D006710:Homocysteine / Q000097:blood*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D051381:Rats
D007328:Insulin; D006710:Homocysteine; D003541:Cystathionine beta-Synthase