title: Multiple 14G stereotactic core biopsies in the diagnosis of mammographically detected stellate lesions of the breast.
abstract: OBJECTIVE
  The aim of this retrospective study was to measure the accuracy of stereotactic guided 14 gauge core biopsy in distinguishing between benign and malignant causes of a mammographically detected stellate breast lesion and to assess the impact of the number of core samples taken on the sensitivity for detection of malignancy.
  
  
  METHODS
  Seventy-two patients with mammographically detected stellate lesions of the breast formed the study group. All patients in the study group underwent multiple 14 gauge core biopsies using prone stereotactic breast biopsy equipment. The diagnostic accuracy of the technique was measured by retrospectively comparing the outcome with the core biopsy results. The result of each core sample was separately recorded to allow analysis of the effect of increasing the number of samples on accuracy.
  
  
  RESULTS
  Nine of 72 (12%) did not have surgery. Forty of 72 (56%) had a benign surgical outcome and 23/72 (32%) a malignant surgical outcome [7/72 (10%) non-invasive, 16/72 (22%) invasive carcinoma]. The absolute sensitivity for multiple stereotactic guided core biopsies of stellate lesions for the detection of malignancy was 78% with a complete sensitivity of 100%. The sensitivity for the detection of invasive carcinoma was 94% (15 out of 16 patients). No statistically significant improvement in sensitivity was shown for multiple samples vs one sample, but in two patients, malignant tissue was only found in core samples 6-9, the first five cores showing atypia only.
  
  
  CONCLUSIONS
  Multiple stereotactic guided 14 gauge core biopsies accurately distinguish malignant from benign causes of stellate breast lesions. When core biopsy histology is malignant, therapeutic surgery can be planned. When the core biopsy shows typical features of a benign radial scar, diagnostic surgical excision may not be required to confirm the diagnosis.Kirwan, S. E., (2000). Clinical Radiology55, 763-766.
authors.affiliation: Breast Screening Assessment and Training Unit, King's College Hospital, Denmark Hill, London SE5 9RS, UK.
authors.forename: S E
authors.initials: SE
authors.lastname: Kirwan
authors.forename: E R
authors.initials: ER
authors.lastname: Denton
authors.forename: R M
authors.initials: RM
authors.lastname: Nash
authors.forename: S
authors.initials: S
authors.lastname: Humphreys
authors.forename: M J
authors.initials: MJ
authors.lastname: Michell
mesh_terms: D001707:Biopsy, Needle / Q000379:methods; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008327:Mammography; D012189:Retrospective Studies; D012680:Sensitivity and Specificity