[The validation of and approaches to the use of immunocorrective agents in contusive eye trauma].
Patients with contusions of the eye of different severity were examined. The concentrations of cytokines (interleukin 1 beta, alpha-interferon, tumor necrosis factor-alpha), levels of immunoglobulins and circulating immune complexes were measured and organ-specific immunity was studied. Severe and medium-severe contusions of the eyeball were associated with immune shifts at a local and systemic levels. Shifts regarded as adaptation compensatory immune response were detected in medium-severe contusions. Severe contusions involve immunity disorders which are characteristic of developing secondary immunodeficiency. Postcontusion hemorrhages are a clinical factor of risk of pathogenetically unfavorable autoimmune reactions. The efficiency of immunocorrective drugs is discussed.
Slepova
O S
OS
Sadrislamova
L F
LF
Gundorova
R A
RA
Alekseeva
I B
IB
Iluridze
S L
SL
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000917:Antibody Formation / Q000187:drug effects; D003288:Contusions / Q000188:drug therapy* / Q000276:immunology; D004359:Drug Therapy, Combination; D005131:Eye Injuries / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008875:Middle Aged; D013997:Time Factors
D000276:Adjuvants, Immunologic