Depressive mood symptoms associated with ovarian suppression.
OBJECTIVE
To determine if sertraline is helpful in the management of depressive symptoms associated with ovarian suppression during GnRH agonist therapy as compared with a placebo-controlled group.


METHODS
Double-blind placebo-controlled prospective study design.


METHODS
An obstetrics/gynecological office specializing in infertility in an academic environment.


METHODS
Premenstrual women with laparoscopically diagnosed endometriosis who required GnRH agonist therapy for treatment and did not have significant depressive or premenstrual mood symptoms at baseline.


METHODS
Participants were randomly assigned to either the sertraline treatment group or to the placebo group for the 3-month duration of the GnRH agonist therapy.


METHODS
The 21-item Hamilton Rating Scale for Depression (HRSD), which is an instrument designed to assess depressive symptomatology.


RESULTS
A Hotellings T(2) test for repeated measure analysis indicated a statistically significant (P<.05) between-group difference across time for the HRSD (T(2) = 13.3; F[3, 28] = 4.1; P=.02) with the sertraline treatment group manifesting significantly fewer depressive symptoms than the control group.


CONCLUSIONS
The results indicate that sertraline is an effective option in the management of depressive mood symptoms associated with ovarian suppression during GnRH agonist therapy.
Warnock
J K
JK
University of Oklahoma Health Sciences Center, Tulsa, 74135, USA. faye-biggs@ouhsc.edu
Bundren
J C
JC
Morris
D W
DW
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000139:chemically induced* / Q000523:psychology; D004311:Double-Blind Method; D004715:Endometriosis / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D010053:Ovary / Q000187:drug effects*; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D020280:Sertraline / Q000627:therapeutic use*
D000928:Antidepressive Agents; D007987:Gonadotropin-Releasing Hormone; D020280:Sertraline