title: Pathogenicity and gene analysis of adenovirus from pigeons with inclusion body hepatitis.
abstract: The pathogenicity of an adenovirus isolated from pigeons (Pigeon adenovirus, PA) with inclusion body hepatitis in Taiwan was investigated in specific-pathogen-free (SPF) chicks and in racing pigeons. One-day-old SPF chicks were inoculated subcutaneously with 10(4) 50% tissue culture infective dose (TCID50, low dose) and 10(8) TCID50 (high dose) of the virus, respectively. The chicks began to die three days post inoculation (DPI) with high dose of the virus and the mortality reached 100%; the chicks began to die 6 DPI and the mortality reached 90% at 14 DPI with low dose. The adult pigeons seemed to be resistant to the PA. However, this virus decreased the production of antibody against Newcastle disease virus in pigeons. It is found that this PA belongs to genetic group D from the restriction patterns produced by BamH I and Hind III.
authors.affiliation: Department of Veterinary Medicine, National Taiwan University, Taipei.
authors.forename: C H
authors.initials: CH
authors.lastname: Wang
authors.forename: C M
authors.initials: CM
authors.lastname: Chang
mesh_terms: D000818:Animals; D000259:Aviadenovirus / Q000235:genetics* / Q000472:pathogenicity*; D001715:Bird Diseases / Q000235:genetics / Q000821:virology*; D010856:Columbidae; D004279:DNA, Viral / Q000737:chemistry; D005814:Genes, Viral; D005838:Genotype; D006520:Hepatitis, Animal / Q000235:genetics / Q000821:virology*; D007181:Inclusion Bodies, Viral; D015183:Restriction Mapping
chemical_list: D004279:DNA, Viral