Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1.
In this study we have used FISH to examine the relationship between a group of homeobox genes, namely DLX1/DLX2, EVX2 and four HOXD genes (10, 11, 12, 13), that map to region q31 on chromosome 2, and the FRA2G and FRA2H fragile sites located at 2q31 and 2q32.1 respectively. Our results indicate that these homeobox genes lie between the two fragile regions.
Limongi
M Z
MZ
Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, Roma, Italia.
Pelliccia
F
F
Gaddini
L
L
Rocchi
A
A
D016590:Aphidicolin / Q000494:pharmacology; D019457:Chromosome Breakage / Q000235:genetics; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D015342:DNA Probes; D005801:Genes, Homeobox / Q000235:genetics*; D018398:Homeodomain Proteins; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007211:Indoles; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D005810:Multigene Family / Q000235:genetics*; D020161:Physical Chromosome Mapping
D015342:DNA Probes; C489493:HOXD11 protein, human; D018398:Homeodomain Proteins; D007211:Indoles; D016590:Aphidicolin; C007293:DAPI