Cell and molecular biological challenges of ICSI: ART before science?
Authors discuss the possible genetic and cell biological risks to offspring conceived by ICSI in relation to the lack of fundamental research using relevant animal models.
Schatten
G
G
Center for Women's Health, Oregon Regional Primate Research Center, Oregon Health Sciences University, Beaverton, USA.
Hewitson
L
L
Simerly
C
C
Sutovsky
P
P
Huszar
G
G
D032761:Animal Experimentation; D000818:Animals; D004622:Embryo, Mammalian / Q000502:physiology; D005260:Female; D005306:Fertilization / Q000502:physiology*; D030342:Genetic Diseases, Inborn; D006801:Humans; D007248:Infertility, Male; D008297:Male; D011247:Pregnancy; D018570:Risk Assessment; D012449:Safety; D012941:Social Responsibility; D020554:Sperm Injections, Intracytoplasmic