Tuftelin mRNA is expressed in a human ameloblastoma tumor.
RT-PCR, Southern blotting and DNA sequencing have established for the first time that tuftelin mRNA is expressed in human ameloblastoma tumor. The expression of amelogenin mRNA in ameloblastoma was also established, confirming earlier reports by Snead et al. These results corroborate, on a molecular level, the enamel organ epithelial origin of ameloblastoma. In view of the present results, it is interesting that previous studies have indicated that although ameloblastoma, a non-mineralized odontogenic tumor, transcribes amelogenin mRNA, amelogenin (and enamelin) proteins are not expressed in this tissue. However, in mineralizing odontogenic tumors, both these classes of proteins are expressed.
Deutsch
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Department of Oral Biology, Hebrew University, Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
Fermon
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Lustmann
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Dafni
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Mao
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Leytin
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Palmon
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D000564:Ameloblastoma / Q000235:genetics*; D053523:Amelogenin; D004273:DNA, Neoplasm / Q000032:analysis; D003746:Dental Enamel Proteins / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D007573:Jaw Neoplasms / Q000235:genetics*; D012333:RNA, Messenger
D053523:Amelogenin; D004273:DNA, Neoplasm; D003746:Dental Enamel Proteins; D012333:RNA, Messenger; C038456:tuftelin