Changes in the apparent diffusion coefficient of water and T2 relaxation time in gerbil hippocampus after mild ischemia.
Selective neuronal death of the hippocampal CA1 area after mild ischemia is known as delayed neuronal death (DND). Progression of DND was evaluated using 7T MRI in gerbils. In the CA1, the T2 relaxation time started to increase on day 3 and was significantly higher on day 4 than that of the control gerbils. However, the apparent diffusion coefficient of water (ADC) was significantly lower on day 1 than in the control and continued to decline up to day 4. Changes in T2 coincided with loss of MAP2 immunoreactivity, while the ADC decrease preceded these changes. After 1 month, the ADC had returned to within the normal range, while T2 had decreased to below the control level. These results suggest that MRI is useful for monitoring DND.
Zhu
L
L
Department of Neurosurgery, University of Tokyo Hospital, Japan.
Saito
N
N
Abe
O
O
Okubo
T
T
Yamada
H
H
Kawahara
N
N
Asai
A
A
Kirino
T
T
D000818:Animals; D001834:Body Water / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism* / Q000473:pathology; D016923:Cell Death / Q000502:physiology; D004058:Diffusion; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D017966:Pyramidal Cells / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D012016:Reference Values; D013997:Time Factors
D008869:Microtubule-Associated Proteins