title: Does the intracarotid amobarbital procedure predict global amnesia after temporal lobectomy?
abstract: OBJECTIVE
  The intracarotid amobarbital procedure (IAP) is widely used to help predict who might be at risk for postoperative amnesia after unilateral temporal lobectomy for intractable seizures. We describe the memory outcome in 10 patients who underwent standard temporal lobectomy, including mesial temporal structures, despite failing the memory portion of the IAP after injections both ipsilateral and contralateral to the resected seizure focus.
  
  
  METHODS
  Data for seven of the study subjects were obtained through a retrospective review of patients assessed on a surgical epilepsy unit during a 15-year period who failed the Montreal Neurological Institute IAP memory protocol after both ipsilateral and contralateral injections and subsequently underwent unilateral temporal lobectomy. More recently, we have studied temporal lobectomy patients who failed the Medical College of Georgia memory protocol after both ipsilateral and contralateral injections (n = 3). Preoperative and postoperative memory test scores were compared, and data regarding seizure outcome and self-perception of postoperative memory were collected.
  
  
  RESULTS
  At follow-up, none of the patients presented with a pattern indicative of a global amnesia, and 80% demonstrated >90% improvement in their seizure disorder or were seizure-free.
  
  
  CONCLUSIONS
  These findings indicate that bilateral memory failure on the IAP does not preclude the removal of an epileptogenic temporal lobe or a successful surgical outcome. In addition, the findings raise questions regarding the validity of the IAP and the possibility that memory may be reorganized in patients with a long history of temporal lobe epilepsy.
authors.affiliation: Psychological Services, London Health Sciences Centre, Ontario, Canada. ckubu@julian.uwo.ca
authors.forename: C S
authors.initials: CS
authors.lastname: Kubu
authors.forename: J P
authors.initials: JP
authors.lastname: Girvin
authors.forename: R S
authors.initials: RS
authors.lastname: McLachlan
authors.forename: M
authors.initials: M
authors.lastname: Pavol
authors.forename: M C
authors.initials: MC
authors.lastname: Harnadek
mesh_terms: D000328:Adult; D000654:Amobarbital; D002343:Carotid Artery, Internal; D015897:Comorbidity; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*; D005500:Follow-Up Studies; D007839:Functional Laterality; D006304:Health Status; D006801:Humans; D007269:Injections, Intra-Arterial; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000175:diagnosis* / Q000453:epidemiology; D011379:Prognosis; D013702:Temporal Lobe / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000654:Amobarbital