[Mediation of excitatory amino acids in synaptic transmission of spinal nociceptive information].
NMDA and non-NMDA receptors exist extensively on the spinal dorsal horn neurons and are involved in mediating neurotransmission of spinal nociceptive information. NMDA receptor mainly mediates the neurotransmission of cutaneous nociceptive information, while non-NMDA receptor mainly contributes to the neurotransmission of muscular and visceral nociceptive information. One of the main reasons for this difference may be that the cutaneous and muscular nociceptive inputs induced more releases of aspartate and glutamate, respectively. There are co-operative interactions among the regulatory sites within NMDA receptor-channel complex in modulation of spinal nociception. The co-operative interaction between excitatory amino acids and substance P in modulation of spinal nociceptive information may occur on both the body and the dendrites of the nociceptive neuron.
Song
X J
XJ
Shanghai Brain Research Institute, Chinese Academy of Sciences.
D000818:Animals; D002415:Cats; D018846:Excitatory Amino Acids / Q000378:metabolism*; D009619:Nociceptors / Q000502:physiology*; D020671:Posterior Horn Cells / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D009435:Synaptic Transmission
D018846:Excitatory Amino Acids; D016194:Receptors, N-Methyl-D-Aspartate