title: [Pneumatic external counterpulsation (PECP): a new treatment option in therapy refractory inner ear disorders?].
abstract: BACKGROUND
  The established therapeutic principle for sudden deafness and tinnitus is based on the stimulation of the inner ear perfusion by infusion therapy using vaso-active or hemodilutive agents. Concerning a mechanically induced increase of the inner ear's blood supply, the new technique of Pneumatic External Counterpulsation (PECP) was performed. This technique had already been used successfully in patients suffering from coronary heart disease. Due to an ECG-guided pneumatic compression of the lower extremities during diastole an increase of arterial perfusion of the extracranial supplying brain vessels can be obtained by PECP-treatment.
  
  
  METHODS
  PECP was used in 33 patients (22 males, 11 females) between 19 and 76 years of age suffering from persisting acute hearing disorders and/or tinnitus after adequate infusion therapy. 3 patients revealed mild complications during PECP-treatment (e.g. thoracic pain) which seemed to be related to the therapeutic regime and disappeared completely after cessation of PECP. 30 patients underwent PECP-treatment on 5 following days for 1 hour. This standardized hourly treatment regime was extended to 10 days in 12 patients. Therapeutic effects were determined by color-coded duplexsonography and pure tone audiometry eventually masking the audiogram.
  
  
  RESULTS
  During treatment an increase of 19% flow volume in the internal carotid arteries and of 11% in the vertebral arteries was evaluated using color-coded duplexsonography. In 47% of cases (n = 14) decrease of tinnitus intensity and/or tinnitus appearance with an average of 16 dB was perceived after the end of the treatment series. Hearing threshold increased in 28% of cases (n = 7) with an average threshold shift of 19 dB after PECP-treatment. All patients were examined by pure tone audiometry during the follow-up after 4, 8 and 12 weeks as well as after 6 and 12 months. In all cases the audiometric benefit lasted throughout the follow-up 1 year, after treatment.
  
  
  CONCLUSIONS
  The determination of a positive correlation between vascular flow increase in the extracranial brain-supplying vessels during PECP-treatment and the encouraging therapeutic results obtained by audiometry seem to make this new and promising therapeutic option effective, practicable and easy to handle. These preliminary results of the PECP technique should be validated in further studies featuring larger numbers of patients suffering from therapy-resistant inner ear disorders.
authors.affiliation: Klinik und Poliklinik für Hals-Nasen- und Ohren-Heilkunde, Universitätsklinikum Carl Gustav Carus der TU Dresden. Offi@rcs.urz.tu-dresden.de
authors.forename: C
authors.initials: C
authors.lastname: Offergeld
authors.forename: D
authors.initials: D
authors.lastname: Werner
authors.forename: M
authors.initials: M
authors.lastname: Schneider
authors.forename: W G
authors.initials: WG
authors.lastname: Daniel
authors.forename: K B
authors.initials: KB
authors.lastname: Hüttenbrink
mesh_terms: D000328:Adult; D000368:Aged; D001301:Audiometry, Pure-Tone; D015908:Counterpulsation; D007758:Ear, Inner / Q000098:blood supply; D005260:Female; D003639:Hearing Loss, Sudden / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D019233:Retreatment; D014012:Tinnitus / Q000209:etiology / Q000628:therapy*