The kings schizotypy questionnaire as a quantitative measure of schizophrenia liability.
We used a new self-report measure, the Kings Schizotypy Questionnaire (KSQ; Williams, M. The psychometric assessment of schizotypal personality. PhD thesis. Institute of Psychiatry, University of London, 1993), to investigate schizotypy as a quantitative measure of familial liability to schizophrenia. The KSQ was administered to 135 DSM-IV schizophrenia probands, 153 of their healthy first-degree relatives, and 267 control subjects. We found that the questionnaire clearly differentiated schizophrenic from non-schizophrenic individuals, but failed to differentiate the relatives from controls. Possible reasons for this include defensive responding among relatives, self-selection bias among relatives, differences in data collection methods, and the possibility that positive aspects of schizotypy may not be closely related to familial liability to schizophrenia.
Jones
L A
LA
Division of Psychological Medicine, University of Wales College of Medicine, Heath Park, CF14 4XN, Cardiff, UK. jonesla1@cardiff.ac.uk
Cardno
A G
AG
Murphy
K C
KC
Sanders
R D
RD
Gray
M Y
MY
McCarthy
G
G
McGuffin
P
P
Owen
M J
MJ
Williams
J
J
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D012559:Schizophrenia / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D006113:United Kingdom / Q000453:epidemiology