title: Lung volume reduction surgery for the treatment of severe emphysema: a study in a single Canadian institution.
abstract: OBJECTIVE
  To evaluate lung volume reduction surgery (LVRS) and its effectiveness in improving pulmonary function, exercise capacity and quality of life in a population of emphysema patients referred to and screened in a single centre.
  
  
  METHODS
  A prospective case series.
  
  
  METHODS
  A Canadian tertiary care hospital.
  
  
  METHODS
  Patients with severe emphysema, significant dyspnea and impaired exercise capacity interfering with quality of life.
  
  
  METHODS
  Bilateral LVRS was performed through a median sternotomy.
  
  
  METHODS
  Pulmonary function tests (preoperative forced expiratory volume in the first second [FEV1], residual volume [RV]), 6-minute walk (6 MW) distance, quality of life (Medical Outcomes Study 36-item short-form health survey) and degree of dyspnea (Medical Research Council of Great Britain dyspnea scale and the baseline and transitional dyspnea indices) were assessed before LVRS and at 6 and 12 months after.
  
  
  RESULTS
  Fifty-seven patients were assessed for LVRS, of whom 10 were selected for surgery. Homogeneous distribution of disease was the most common reason for exclusion. Of the 10 patients operated upon, 1 died of acute cor pulmonale on the fourth postoperative day and 1 died of recurrent exacerbations of chronic obstructive pulmonary disease and chronic respiratory failure at 315 days postoperatively. In the surviving patients, the mean preoperative FEV1 increased from 0.70 L before surgery to 0.90 L at 1 year, with a mean relative increase of 33.4%. The mean RV decreased from 5.57 L to 4.10 L, with a mean relative decrease of 27.6%. The 6 MW distance increased from 302.7 m to 356.9 m at 1 year, with a mean relative increase of 21.6%. Quality of life and degree of dyspnea were improved significantly at 1 year after LVRS. Of the 5 patients on oxygen at home before surgery, 4 were able to reduce their requirements but not to discontinue oxygen.
  
  
  CONCLUSIONS
  LVRS is an effective palliative treatment for dyspnea and poor exercise tolerance in highly selected patients. Although the duration of palliation is unknown, our results show that improvements in pulmonary function, exercise, quality of life and degree of dyspnea are preserved over the first year. Only a minority of the patients screened were eligible for surgery. The 2 deaths in our series emphasize the need for even further delineation of selection criteria.
authors.affiliation: Department of Surgery, Health Sciences Centre, University of Manitoba, Winnipeg.
authors.forename: A L
authors.initials: AL
authors.lastname: Tan
authors.forename: H W
authors.initials: HW
authors.lastname: Unruh
authors.forename: S N
authors.initials: SN
authors.lastname: Mink
mesh_terms: D000368:Aged; D002170:Canada; D004417:Dyspnea / Q000209:etiology / Q000601:surgery; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D010166:Palliative Care; D011183:Postoperative Complications; D011446:Prospective Studies; D011656:Pulmonary Emphysema / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy; D011788:Quality of Life; D016896:Treatment Outcome