[FruA, a transcription factor in Myxococus xamthus, regulates transcription of target genes in collaboration with the associated protein FruB].
Many developmental genes are regulated by FruA, a transcription factor essential for the development of Myxococus xamthus. Another protein, designated FruB, was purified from myxobacteria by its affinity to FruA. FruB could be phosphorylated by protein kinase(s) located in cell membrane. Gel shift assay showed that FruA regulates transcription of target genes in collaboration with phosphorylated FruB. This study may shed light on the molecular mechanisms of regulatory network involved in the development of Myxococus xamthus.
Mao
X H
XH
Department of Biochemistry, Nanjing Railway Medical College, China.
Ding
L
L
Wang
D Y
DY
D001426:Bacterial Proteins / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology*; D004247:DNA / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D016941:Myxococcus xanthus / Q000235:genetics* / Q000502:physiology; D010766:Phosphorylation; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D002352:Carrier Proteins; C104848:FruA protein, Myxococcus xanthus; D047908:Intracellular Signaling Peptides and Proteins; D014157:Transcription Factors; C028640:fructose-induced HPr-like protein, bacteria; D004247:DNA