Cardiovascular disease in diabetes mellitus type 2: a potential role for novel cardiovascular risk factors.
A major consequence of diabetes mellitus type 2 is the accelerated development of atherosclerosis. Assessment of conventional risk factors such as plasma lipids, lipoproteins and hypertension only partly account for the excessive risk of developing cardiovascular disease in this population. Increasing evidence has emerged suggesting that conditions associated with diabetes mellitus type 2, such as insulin resistance, hyperinsulinemia and hyperglycemia, may also play a significant role in regulating 'novel' cardiovascular risk factors. These factors and their potential roles in the development of atherosclerosis and cardiovascular events are discussed in this review.
Hayden
J M
JM
Department of Medicine, Carl T. Hayden Veterans Administration Medical Center, Phoenix, Arizona 85012-1892, USA.
Reaven
P D
PD
D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000209:etiology / Q000378:metabolism; D004730:Endothelium, Vascular / Q000503:physiopathology; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D018836:Inflammation Mediators / Q000097:blood; D008077:Lipoproteins, LDL / Q000378:metabolism; D008954:Models, Biological; D009000:Monocytes / Q000502:physiology; D018384:Oxidative Stress; D012307:Risk Factors
D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D018836:Inflammation Mediators; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein