[Pneumocystis carinii pneumonia associated with acquired immunodeficiency syndrome followed by KL-6, surfactant protein-D and beta-D-glucan in serum].
A 40-year-old man was admitted to our hospital with acute respiratory failure. The patient was given a diagnosis of Pneumocystis carinii pneumonia (PCP) associated with acquired immunodeficiency syndrome (AIDS). After treatment with trimethoprim-sulfamethoxazole and corticosteroid, the respiratory failure was improved and the abnormal shadows disappeared. The serum beta-D-glucan level, significantly elevated (76.0 pg/ml) on admission, returned to the normal range within two weeks. Serum KL-6 (max. 7580 U/ml) and surfactant protein-D (SP-D) (max. 235 ng/ml), which are produced by type II pneumocytes, increased after elevation of the beta-D-glucan level and decreased gradually following successful treatment. These findings suggest that beta-D-glucan may be a serological marker for PCP infection and KL-6 may be a serological marker for lung injury in PCP with AIDS.
Murakami
T
T
Department of Respiratory Medicine, Showa General Hospital, Tokyo, Japan.
Suzuki
M
M
Okada
S
S
Suzuki
J
J
Nagaoka
T
T
Sakamoto
K
K
Aoki
S
S
Matsuoka
R
R
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000328:Adult; D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood; D005936:Glucans / Q000097:blood*; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008297:Male; D018396:Mucin-1; D009077:Mucins; D010446:Peptide Fragments / Q000097:blood*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis*; D011347:Procollagen / Q000097:blood*; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants / Q000097:blood; D047071:beta-Glucans
D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D005936:Glucans; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D010446:Peptide Fragments; D011347:Procollagen; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants; D047071:beta-Glucans; C041876:procollagen Type III-N-terminal peptide; C033363:beta-1,3-glucan