Genes that control the development of migrating muscle precursor cells.
Skeletal muscles in vertebrates, despite their functional and biochemical similarities, are generated via diverse developmental mechanisms. A major subclass of hypaxial muscle groups is derived from long-range migrating progenitor cells that delaminate from the dermomyotome. The development of this lineage is controlled by Pax3, the c-Met tyrosine kinase receptor, its ligand SF/HGF (scatter factor/hepatocyte growth factor) and the homeobox factor Lbx1. These molecules are essential for establishment of the precursor pool, delamination, migration and target finding. Progress has been made in understanding patterning of the muscles, which requires a precise control of proliferation and differentiation of myogenic precursor cells.
Birchmeier
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Max-Delbrueck-Centre for Molecular Medicine, Robert-Roessle-Strasse 10, 13092, Berlin, Germany. cbirch@mdc-berlin.de
Brohmann
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D000818:Animals; D030161:Avian Proteins; D019521:Body Patterning / Q000502:physiology; D017173:Caenorhabditis elegans; D019070:Cell Lineage / Q000502:physiology; D002465:Cell Movement / Q000235:genetics*; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000378:metabolism; D005121:Extremities / Q000196:embryology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D051379:Mice; D009124:Muscle Proteins / Q000378:metabolism; D018482:Muscle, Skeletal / Q000166:cytology* / Q000196:embryology*; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D014157:Transcription Factors
D030161:Avian Proteins; D004268:DNA-Binding Proteins; C113279:LBX1 protein, Gallus gallus; C491868:Lbx1h protein, mouse; D009124:Muscle Proteins; D000072041:PAX3 Transcription Factor; D051761:Paired Box Transcription Factors; D014157:Transcription Factors; C068686:Pax3 protein, mouse; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met