Cytokine, activation marker, and chemokine receptor expression by individual CD4(+) memory T cells in rheumatoid arthritis synovium.
IL-10, IL-13, IFN-gamma, tumor necrosis factor (TNF)-alpha, LT-alpha, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4(+) memory T cells, whereas CD4(+) cells that produced IL-2, IL-4, or IL-6 were not detected. Expression of none of these molecules by individual CD4(+) cells correlated with the exception of TRANCE and IL-10, and TRANCE and TNF-alpha. A correlation between expression of IL-10 and CCR7, LT-alpha and CCR6, IFN-gamma and CCR5, and TRANCE and CXCR4 was also detected.
Nanki
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Department of Internal Medicine and Harold C Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA. nanki.med1@med.tmd.ac.jp
Lipsky
P E
PE
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000235:genetics / Q000276:immunology*; D015415:Biomarkers / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000235:genetics*; D006801:Humans; D007156:Immunologic Memory / Q000502:physiology*; D008213:Lymphocyte Activation / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D019707:Receptors, Chemokine / Q000235:genetics*; D013583:Synovial Membrane / Q000276:immunology* / Q000503:physiopathology
D015415:Biomarkers; D016207:Cytokines; D012333:RNA, Messenger; D019707:Receptors, Chemokine