Involvement of neuropeptide Y and Y1 receptor in antinociception in nucleus raphe magnus of rats.
The nociceptive response latencies increased significantly after intra-nucleus raphe magnus administration of 0.1 or 0.4 nmol of neuropeptide Y, but not 0.04 nmol, in rats. The neuropeptide Y-induced increases in hindpaw withdrawal latency were reversed by following injection of 0.42 nmol of the Y1 antagonist, NPY(28-36). The results indicate that NPY plays an antinociceptive role in nucleus raphe magnus in rats, which is mediated by the Y1 receptor. Furthermore, the neuropeptide Y-induced increases in hindpaw withdrawal latency were attenuated by following intra-nucleus raphe magnus injection of 6 nmol of the opioid antagonist naloxone, indicating that there is an interaction between NPY and opioids in nucleus raphe magnus.
Zhang
Y
Y
Department of Physiology, College of Life Sciences, Peking University, 100871, Beijing, China.
Lundeberg
T
T
Yu
L
L
D000818:Animals; D006358:Hot Temperature; D008297:Male; D008845:Microinjections; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D009478:Neuropeptide Y / Q000494:pharmacology* / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology; D011903:Raphe Nuclei / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D017476:Receptors, Neuropeptide Y / Q000502:physiology*
D009478:Neuropeptide Y; D010446:Peptide Fragments; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; D009270:Naloxone