title: Bariatric surgery for morbid obesity.
abstract: BACKGROUND
  Bariatric surgery is a treatment for severely obese patients. We examined the efficacy of bariatric surgery, addressing three questions: 1) What is the overall weight reduction following bariatric surgery? 2) What complications are associated with bariatric surgery? 3) What impact does weight loss have on obesity-related comorbidity?
  
  
  METHODS
  Fixed and random effects meta-analyses were used to determine the amount of weight reduction following bariatric surgery. The influence of a variety of co-variates that could affect study results was examined. Information from evidence-based sources was used to explore the impact of weight loss on comorbidities.
  
  
  RESULTS
  Meta-analyses results were affected by loss to follow-up, and within-study heterogeneity of variance. Therefore, results were pooled from studies with complete patient follow-up. Meta-analysis of six studies reporting weight loss at 1 year and four studies with mean follow-up of 9 months to 7 years demonstrated BMI reductions of 16.4 kg/m(2) and 13.3 kg/m(2), respectively. Weight reduction following bariatric surgery may be associated with improvements in risk factors for cardiac disease including hypertension, type 2 diabetes and lipid abnormalities, and may decrease the severity of obstructive sleep apnea.
  
  
  CONCLUSIONS
  Bariatric surgery is appropriate for obese patients (BMI >40 kg/m(2) or > or =35 kg/m(2) with obesity-related comorbidity) in whom non-surgical treatment options were unsuccessful. Additional research is needed to examine the long-term benefits of weight loss following bariatric surgery, particularly with respect to obesity-related comorbidities.
authors.affiliation: ECRI Plymouth Meeting, Pennsylvania 19462-1298, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Monteforte
authors.forename: C M
authors.initials: CM
authors.lastname: Turkelson
mesh_terms: D015992:Body Mass Index; D015897:Comorbidity; D015390:Gastric Bypass; D015391:Gastroplasty; D006801:Humans; D009767:Obesity, Morbid / Q000453:epidemiology / Q000601:surgery*; D016896:Treatment Outcome