title: Mater, a maternal effect gene required for early embryonic development in mice.
abstract: Maternal effect genes produce mRNA or proteins that accumulate in the egg during oogenesis. We show here that Mater, a mouse oocyte protein dependent on the maternal genome, is essential for embryonic development beyond the two-cell stage. Females lacking the maternal effect gene Mater are sterile. Null males are fertile.
authors.affiliation: Developmental Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Z B
authors.initials: ZB
authors.lastname: Tong
authors.forename: L
authors.initials: L
authors.lastname: Gold
authors.forename: K E
authors.initials: KE
authors.lastname: Pfeifer
authors.forename: H
authors.initials: H
authors.lastname: Dorward
authors.forename: E
authors.initials: E
authors.lastname: Lee
authors.forename: C A
authors.initials: CA
authors.lastname: Bondy
authors.forename: J
authors.initials: J
authors.lastname: Dean
authors.forename: L M
authors.initials: LM
authors.lastname: Nelson
mesh_terms: D000818:Animals; D000941:Antigens; D001755:Blastocyst / Q000473:pathology; D004527:Egg Proteins / Q000235:genetics / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D005327:Fetal Resorption / Q000235:genetics; D005796:Genes; D018392:Genomic Imprinting / Q000235:genetics*; D007247:Infertility, Female / Q000235:genetics; D016350:Leucine Zippers / Q000235:genetics / Q000502:physiology; D051379:Mice / Q000196:embryology / Q000235:genetics*; D018345:Mice, Knockout; D009865:Oocytes / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D023121:RNA, Messenger, Stored / Q000235:genetics
chemical_list: D000941:Antigens; D004527:Egg Proteins; C416503:Nalp5 protein, mouse; D023121:RNA, Messenger, Stored