Evaluation in the baboon model of (99m)Tc-biguanide as a tracer for renal imaging.
Studies in various animal species have recently shown that (99m)Tc-BIG has practical and dosimetric benefits for renal imaging that could probably make it a good alternative to (99m)Tc-2, 3-dimercaptosuccinic acid ((99m)Tc-DMSA). In this study, using the baboon experimental model, the biodistribution of (99m)Tc-BIG and (99m)Tc-DMSA are compared. It is demonstrated that early good contrast imaging and more favourable dosimetry is possible with (99m)Tc-BIG compared to (99m)Tc-DMSA, confirming the quoted previous findings with small animals. Time-activity curves for kidneys and other organs support these findings, and MIRDOSE software provided the dosimetry.
Neves
M
M
Instituto Tecnológico e Nuclear, Sacavém, Portugal. mneves@itn1.itn.pt
Dormehl
I
I
Kilian
E
E
Louw
W
W
Lalaoui
K
K
Pedroso de Lima
J J
JJ
D000818:Animals; D001645:Biguanides / Q000493:pharmacokinetics*; D004353:Drug Evaluation, Preclinical; D006321:Heart / Q000000981:diagnostic imaging; D007668:Kidney / Q000000981:diagnostic imaging* / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D010215:Papio; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D011880:Radiotherapy Planning, Computer-Assisted; D013154:Spleen / Q000000981:diagnostic imaging / Q000378:metabolism; D019783:Technetium Tc 99m Dimercaptosuccinic Acid / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D001645:Biguanides; D019275:Radiopharmaceuticals; C417905:technetium Tc 99m biguanide; D019783:Technetium Tc 99m Dimercaptosuccinic Acid