[Frequency analysis of the QRS complex: a new method of detecting development of myocardial damage after anthracycline cytostatics].
The aim of the study was to investigate the effect of the new modification of frequency-domain analysis of ECG signal (gliding-window FFT) in long-term monitoring of cardiac status of patients who received a potentially cardiotoxic anthracycline therapy in childhood. Area ratio (60-120/0-120 Hz) peaks within QRS complex were significantly higher in 60 patients compared with 70 healthy children and young adults. Persistent abnormalities in frequency content of ECG signal in oncologic patients might indicate myocardial damage induced by anthracyclines. (Fig. 1, Ref. 17.)
Mladosievicova
B
B
Department of Clinical Pathophysiology, School of Medicine, Comenius University, Bratislava, Slovakia. mladosievic@fmed.uniba.sk
Foltinova
A
A
Paulovic
P
P
Petrasova
H
H
Hulin
I
I
D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D003630:Daunorubicin / Q000009:adverse effects*; D004317:Doxorubicin / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D012815:Signal Processing, Computer-Assisted
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D004317:Doxorubicin; D003630:Daunorubicin