U-50,488H, a kappa opioid receptor agonist, is a more potent blocker of cardiac sodium channels than lidocaine.
Pugsley
M K
MK
Department of Microbiology & Molecular Genetics, University of California, Irvine 92697-4025, USA.
Yu
E J
EJ
Goldin
A L
AL
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D004594:Electrophysiology; D006321:Heart / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D009865:Oocytes / Q000187:drug effects / Q000378:metabolism; D018408:Patch-Clamp Techniques; D051381:Rats; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D026941:Sodium Channel Blockers; D014982:Xenopus laevis
D000889:Anti-Arrhythmia Agents; D017473:Receptors, Opioid, kappa; D026941:Sodium Channel Blockers; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D004247:DNA; D008012:Lidocaine