Repetitive transcranial magnetic stimulation does not replicate the Wada test.
The authors compared inferior frontal speech arrest from repetitive transcranial magnetic stimulation (rTMS) with bilateral Wada tests in 17 epilepsy surgery candidates. Although rTMS lateralization correlated with the Wada test in most subjects, rTMS also favored the right hemisphere at a rate significantly greater than the Wada test. Postoperative language deficits were more consistent with Wada results. Available methods for inducing speech arrest with rTMS do not replicate the results of Wada tests.
Epstein
C M
CM
Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. chipstein@aol.com
Woodard
J L
JL
Stringer
A Y
AY
Bakay
R A
RA
Henry
T R
TR
Pennell
P B
PB
Litt
B
B
D000654:Amobarbital; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D013064:Speech Disorders / Q000175:diagnosis* / Q000503:physiopathology; D050781:Transcranial Magnetic Stimulation
D000654:Amobarbital