Clastogenic effect of ginger rhizome in mice.
The present study focuses on the clastogenic effect of ginger rhizome. Crude aqueous extracts of ginger were gavaged at doses of 0. 5, 1, 2, 5, 10 g/kg body weight and ginger oil (0.625, 1.250 and 2. 50 ml/kg body weight) was administered by intraperitoneal injection to male mice. Chromosome damage was studied in a preparation made from bone marrow cells following colchicine injection to all mice and examination of the cells after pretreatment in hypotonic solution, fixation, air drying and staining in Giemsa solution. Attention is drawn to the weakness of the clastogenic activity expressed by the ginger extract. In comparison ginger oil gave a higher frequency of chromosomal aberrations. It is suggested therefore, that the extract may contain substance(s) that suppress clastogenesis in the bone marrow cells of mice.
Mukhopadhyay
M J
MJ
Centre for Advanced Study in Cell and Chromosome Research, Department of Botany, University of Calcutta, Calcutta, India.
Mukherjee
A
A
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations; D020939:Zingiber officinale; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009153:Mutagens / Q000008:administration & dosage / Q000494:pharmacology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal
D009153:Mutagens; D010936:Plant Extracts