Chromatin remodeling and Rb activity.
Progression of cells through the cell cycle is central to normal cell proliferation, and checkpoints that regulate this cycle are targets of tumorigenic mutations. One of these checkpoints is the Rb family of proteins that seems to regulate exit of cells from both G(1) and S phase of the cell cycle. Recent studies have linked the function of the Rb family to chromatin remodeling enzymes.
Harbour
J W
JW
Division of Molecular Oncology, Washington University, St Louis, Missouri 63110, USA.
Dean
D C
DC
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004265:DNA Helicases; D029721:Drosophila Proteins; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D009707:Nucleosomes / Q000378:metabolism; D016601:RNA-Binding Proteins; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism*; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D002843:Chromatin; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D009707:Nucleosomes; D016601:RNA-Binding Proteins; D016160:Retinoblastoma Protein; D017412:Ribonucleoprotein, U1 Small Nuclear; C084011:SMARCA2 protein, human; D014157:Transcription Factors; C089969:snf protein, Drosophila; D000255:Adenosine Triphosphate; D006655:Histone Deacetylases; C084108:SMARCA4 protein, human; D004265:DNA Helicases