title: Hunting the emesis and efficacy targets of PDE4 inhibitors: identification of the photoaffinity probe 8-(3-azidophenyl)-6- [(4-iodo-1H-1-imidazolyl)methyl]quinoline (APIIMQ).
authors.affiliation: Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Québec, Canada, H9R 4P8. dwight_macdonald@merk.com
authors.forename: D
authors.initials: D
authors.lastname: Macdonald
authors.forename: H
authors.initials: H
authors.lastname: Perrier
authors.forename: S
authors.initials: S
authors.lastname: Liu
authors.forename: F
authors.initials: F
authors.lastname: Laliberté
authors.forename: R
authors.initials: R
authors.lastname: Rasori
authors.forename: A
authors.initials: A
authors.lastname: Robichaud
authors.forename: P
authors.initials: P
authors.lastname: Masson
authors.forename: Z
authors.initials: Z
authors.lastname: Huang
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016084:Bronchoconstriction / Q000187:drug effects; D002460:Cell Line; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005289:Ferrets; D006168:Guinea Pigs; D006801:Humans; D019920:Photoaffinity Labels / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011993:Recombinant Fusion Proteins / Q000037:antagonists & inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014839:Vomiting / Q000139:chemically induced*
chemical_list: C415562:8-(3-azidophenyl)-6-((4-iodo-1H-1-imidazolyl)methyl)quinoline; D018927:Anti-Asthmatic Agents; D001386:Azides; D004791:Enzyme Inhibitors; D019920:Photoaffinity Labels; D011804:Quinolines; D011993:Recombinant Fusion Proteins; D014409:Tumor Necrosis Factor-alpha; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4