Role of immune-derived diffusible mediators in AIDS-associated neurological disorders.
Neurologic abnormalities are common in HIV-1 infected patients and often represent the dominant clinical manifestation of pediatric AIDS. Although the neurological dysfunction has been directly related to CNS invasion by HIV-1, the pathogenesis of neurologic disorders remains unclear. This review will first discuss the spectrum of potential interactions between HIV-1 and neural (neuronal and glial) cells, in the face of experimental data. Next, we will focus on the role of immune-derived cytokines and other soluble compounds which have been proposed to act as neurotoxic mediators and appear to play a role in the pathogenesis of AIDS-associated neurodegeneration.
Ensoli
F
F
Department of Allergy and Clinical Immunology, University of Rome, La Sapienza, Italy. ensolifior@uniroma1.it
Fiorelli
V
V
De Cristofaro
M
M
Muratori
D S
DS
Novi
A
A
Isgrò
A
A
Aiuti
F
F
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D004058:Diffusion; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D009422:Nervous System Diseases / Q000150:complications / Q000276:immunology*; D009457:Neuroglia / Q000276:immunology; D009474:Neurons / Q000276:immunology; D009498:Neurotoxins / Q000096:biosynthesis*
D009498:Neurotoxins