title: Massive cerebral edema after I.V. cyclosporin overdose.
abstract: We describe a patient who accidentally received an infusion of cyclosporin at a rate of 30 mg/hr during 13 hr instead of the prescribed dose of 3 mg/hr and who concomitantly developed massive intracerebral edema with brainstem compression and death. A cyclosporin level as high as 1700 ng/ml could have been reached before the drug was withdrawn. To the best of our knowledge, this is the first case of fatal cyclosporin overdose reported in an adult patient.
authors.affiliation: Division of Surgical Intensive Care, University Hospital of Geneva, Switzerland. marcdeperrot@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: de Perrot
authors.forename: A
authors.initials: A
authors.lastname: Spiliopoulos
authors.forename: S
authors.initials: S
authors.lastname: Cottini
authors.forename: L
authors.initials: L
authors.lastname: Nicod
authors.forename: B
authors.initials: B
authors.lastname: Ricou
mesh_terms: D001929:Brain Edema / Q000139:chemically induced*; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D062787:Drug Overdose / Q000209:etiology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
chemical_list: D016572:Cyclosporine