Massive cerebral edema after I.V. cyclosporin overdose.
We describe a patient who accidentally received an infusion of cyclosporin at a rate of 30 mg/hr during 13 hr instead of the prescribed dose of 3 mg/hr and who concomitantly developed massive intracerebral edema with brainstem compression and death. A cyclosporin level as high as 1700 ng/ml could have been reached before the drug was withdrawn. To the best of our knowledge, this is the first case of fatal cyclosporin overdose reported in an adult patient.
de Perrot
M
M
Division of Surgical Intensive Care, University Hospital of Geneva, Switzerland. marcdeperrot@hotmail.com
Spiliopoulos
A
A
Cottini
S
S
Nicod
L
L
Ricou
B
B
D001929:Brain Edema / Q000139:chemically induced*; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D062787:Drug Overdose / Q000209:etiology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged
D016572:Cyclosporine