title: Association study of schizophrenia spectrum disorders and dopamine D3 receptor gene: is schizoaffective disorder special?
abstract: Alterations in dopamine neurotransmission have been hypothesized to play a role in the etiology of schizophrenia. We considered the dopamine D3 receptor gene on chromosome 3 as a candidate gene for an association analysis. We compared PCR-based genotype markers for healthy controls (n=120) and patients (n=95) with schizophrenia and schizophrenia spectrum disorders as diagnosed by consensus according to DSM-III-R. Our results possibly indicate an association of schizoaffective disorder with DRD3 homozygosity (P=0.056).
authors.affiliation: University Hospital for Psychiatry, Department of General Psychiatry, Währinger Gürtel 18-20, A-1090, Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Meszaros
authors.forename: E
authors.initials: E
authors.lastname: Lenzinger
authors.forename: K
authors.initials: K
authors.lastname: Hornik
authors.forename: T
authors.initials: T
authors.lastname: Füreder
authors.forename: T
authors.initials: T
authors.lastname: Stompe
authors.forename: U
authors.initials: U
authors.lastname: Willinger
authors.forename: A
authors.initials: A
authors.lastname: Heiden
authors.forename: N
authors.initials: N
authors.lastname: Fathi
authors.forename: E
authors.initials: E
authors.lastname: Gerhard
authors.forename: K
authors.initials: K
authors.lastname: Fuchs
authors.forename: W
authors.initials: W
authors.lastname: Sieghart
authors.forename: S
authors.initials: S
authors.lastname: Kasper
authors.forename: H N
authors.initials: HN
authors.lastname: Aschauer
mesh_terms: D000328:Adult; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006720:Homozygote; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
chemical_list: C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3