title: [99m Tc-MIBI scintigraphy compared to mammography in the diagnosis of breast cancer in dense, operated and young women breasts].
abstract: Breast scintimammography with 99mTc-MIBI has proven to be a useful complement to mammography in the diagnosis of breast cancer in the female population. Although the mammography, along with a physical examination, is the backbone of breast cancer diagnosis, there are groups of patients in whom the mammography has an even lower specificity.
  
  
  OBJECTIVE
  Our study has aimed to assess the usefulness of breast 99mTc-MIBI scintimammography in those situations in which the mammography was indeterminate, such as, in dense breasts, young females or breasts with architectural distortion after surgery or radiation therapy.
  
  
  METHODS
  We studied 109 females with mammographically dense breasts, 8 young females under 30 and 24 patients who had undergone previous surgery or radiation therapy. All cases were studied to rule out breast cancer. Final diagnosis was established with excisional biopsy.
  
  
  RESULTS
  In dense breasts MIBI scintimammography sensitivity was 88% and the mammography one 81%. MIBI scintimammography specificity was 90% and the mammography 28%. In young females MIBI scintimammography sensitivity was 100% and the mammography 50%, MIBI scintimammography specificity 100% and the mammography 20%. In previous surgery, MIBI scintimammography sensitivity was 80% and the mammography 80%, MIBI scintimammography specificity 100% and the mammography 42%.
  
  
  CONCLUSIONS
  Breast scintimammography with 99mTc-MIBI is an excellent diagnostic technique with high specificity. Undoubtedly it is complementary to mammography in those cases where mammography has major limitations such as dense breasts, young females and breasts with severe scarring after surgery or radiation therapy.
authors.affiliation: Servicio de Medicina Nuclear. Hospital Universitario Virgen de la Arrixaca. Murcia. mulerof@teleline.es
authors.forename: F
authors.initials: F
authors.lastname: Mulero
authors.forename: F
authors.initials: F
authors.lastname: Nicolás
authors.forename: M I
authors.initials: MI
authors.lastname: Castellón
authors.forename: T
authors.initials: T
authors.lastname: Fuentes
authors.forename: P
authors.initials: P
authors.lastname: de la Cruz
authors.forename: V
authors.initials: V
authors.lastname: Roca
authors.forename: L
authors.initials: L
authors.lastname: Abad
authors.forename: J A
authors.initials: JA
authors.lastname: Nuño de La Rosa
mesh_terms: D000328:Adult; D000367:Age Factors; D001940:Breast / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008327:Mammography; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi