title: [Study of dimerization of polysynthetic derivatives of the antibiotic eremomycin by ESI MS and its role in elucidating antibacterial activity].
abstract: The dimerization constants for glycopeptide antibiotics vancomycin, ristocetin, and eremomycin and nine semisynthetic eremomycin derivatives were determined by the electrospray ionization mass spectrometry; the constants for natural antibiotics turned out to be close to those previously determined by NMR. No correlation between these dimerization constants and antibacterial activities of all the compounds toward the clinical strains of Gram-positive bacteria was found.
authors.affiliation: Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: O A
authors.initials: OA
authors.lastname: Mirgorodskaia
authors.forename: E N
authors.initials: EN
authors.lastname: Olsuf'eva
authors.forename: D E
authors.initials: DE
authors.lastname: Kolume
authors.forename: T J
authors.initials: TJ
authors.lastname: Joergensen
authors.forename: P
authors.initials: P
authors.lastname: Roepstorff
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Pavlov
authors.forename: O V
authors.initials: OV
authors.lastname: Miroshnikova
authors.forename: M N
authors.initials: MN
authors.lastname: Preobrazhenskaia
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D019281:Dimerization; D006020:Glycopeptides; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C053759:eremomycin