Protein C deficiency related to valproic acid therapy: a possible association with childhood stroke.
We report a case of stroke in a child with acquired protein C deficiency receiving valproic acid (VPA). To investigate the possible association of VPA with protein C deficiency, protein C levels were measured in 20 children receiving VPA monotherapy and 20 children receiving other anticonvulsants. Protein C levels were reduced in up to 45% of the VPA-treated subjects.
Gruppo
R
R
Divisions of Hematology/Oncology and Neurology, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
Degrauw
A
A
Fogelson
H
H
Glauser
T
T
Balasa
V
V
Gartside
P
P
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D000991:Antithrombins / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D007223:Infant; D010976:Platelet Count; D011486:Protein C / Q000378:metabolism*; D020151:Protein C Deficiency / Q000139:chemically induced* / Q000150:complications*; D017293:Protein S / Q000378:metabolism; D012640:Seizures / Q000188:drug therapy; D020521:Stroke / Q000209:etiology*; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D000991:Antithrombins; D011486:Protein C; D017293:Protein S; D014635:Valproic Acid; D005340:Fibrinogen