Natural history of early colorectal cancer: evolution of a growth curve.
OBJECTIVE
There are very few studies on the development of early colorectal cancers, although we have previously reported growth speeds of early colorectal cancer in a radiographic retrospective study. The aim of this study was to estimate a statistical curve for cancer growth from mucosal cancer.


METHODS
Subjects of the study were 31 patients with cancer in which initial lesions were diagnosed as mucosal cancer. These lesions were overlooked in the first or second investigations, but were detected later. Initial radiographic features were as follows; 4 pedunculated lesions, 1 semipedunculated lesion, 6 sessile lesions, 9 superficially elevated lesions, and 11 superficially depressed lesions. The diameters of the initial lesions were 12.1+/-6.1 mm. The final depths of invasion were 6 mucosal cancers, 12 submucosal cancers, 6 muscularis propria cancers, and 7 serosal cancers. The observation period between the initial and final examination was 41.5+/-25.8 months. The growth curve was estimated by an exponential curve with the natural logarithm of d = e (a + b x t), where a is the intercept (initial tumor size) and b is the regression coefficient (growth speed).


RESULTS
A growth curve was obtained as follows: diameter = 12.5 x 2(t/77) (r = 0.448, P < 0.0001) and 95 percent confidence interval of time = 53 to 173 months. Subsequently, volume = 1 x 10(3) x 2(t/26), and the 95 percent confidence interval of time = 18 to 58 months.


CONCLUSIONS
Growth speed of early colorectal cancer was estimated through a statistically significant growth curve. Estimated doubling time of the volume of early colorectal cancer was 26 (95 percent confidence interval, 18-58) months. From these results we could obtain a rational cancer surveillance program using appropriate procedures with different sensitivities.
Matsui
T
T
Department of Gastroenterology, Fukuoka University Chikushi Hospital, Japan.
Tsuda
S
S
Yao
K
K
Iwashita
A
A
Sakurai
T
T
Yao
T
T
D000368:Aged; D002455:Cell Division; D015179:Colorectal Neoplasms / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors