Effects of estrogen and alendronate on sister chromatid exchange (SCE) frequencies in postmenopausal osteoporosis patients.
OBJECTIVE
To compare two types of osteoporosis treatment for genotoxicity by using sister chromatid exchange (SCE) frequencies.


METHODS
Fifty-seven women, aged between 40 and 64 years, composed the population in the study. SCE values of patients under estrogen replacement therapy (ERT) or alendronate therapy were compared to controls who never used any drugs for osteoporosis.


RESULTS
The difference between the SCE values of women taking ERT and control women was found to be statistically significant (P<0.05). The difference between women taking alendronate and untreated controls was not statistically significant.


CONCLUSIONS
Our results indicate that alendronate does not have genotoxic effects based on SCE frequency, while ERT increases SCE frequencies.
Sahin
F I
FI
Gazi University Faculty of Medicine, Department of Medical Biology and Genetics, Beşevler, Ankara, Turkey. feridesahin@hotmail.com
Sahin
I
I
Ergün
M A
MA
Saraçoğlu
O F
OF
D000328:Adult; D019386:Alendronate / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D005787:Gene Frequency / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009152:Mutagenicity Tests; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D019386:Alendronate