title: On the sweetness of N-(trifluoroacetyl)aspartame.
abstract: A panel of tasters has found that the N-trifluoroacetyl derivative of aspartame is five times less sweet than the parent compound, contrary to the tenet in the literature, but consistent with sweet receptor models which require this nitrogen to exist in protonated form.
authors.affiliation: Laboratoire SEESIB-CNRS-UMR 6504, Departement de Chimie, Université Blaise Pascal-Clermont-Ferrand II, Aubière, France.
authors.forename: M
authors.initials: M
authors.lastname: Frank
authors.forename: D J
authors.initials: DJ
authors.lastname: Aitken
mesh_terms: D001218:Aspartame / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D013329:Structure-Activity Relationship; D013395:Sucrose; D013549:Sweetening Agents / Q000737:chemistry; D013649:Taste
chemical_list: C419926:N-(trifluoroacetyl)aspartame; D013549:Sweetening Agents; D013395:Sucrose; D001218:Aspartame