Development of vaccines against human parasitic diseases: tools, current status and perspectives.
Vaccines against malaria, leishmaniasis and schistosomiasis are in the most advanced stages of development of all vaccines for human parasitic diseases. Despite the remarkable progress made in identifying and producing protective antigens, at present there are no generally accepted vaccines against parasitic diseases. Vaccines for malaria and leishmaniasis have been taken to clinical trials while vaccines for schistosomiasis are in Phase I/II trials. This review will focus on the most promising antigenic preparations, emphasising the tools, present status and perspectives for development of vaccines against malaria, leishmaniasis and schistosomiasis.
Abath
F G
FG
Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Av. Moraes, Rego s/n, Cidade Universitaria, 50670-420, Recife-PE, Brazil. fabath@gene.dbbm.fiocruz.br
D000818:Animals; D015507:Drugs, Investigational; D006801:Humans; D007891:Leishmania / Q000276:immunology; D007896:Leishmaniasis / Q000517:prevention & control*; D008288:Malaria / Q000517:prevention & control*; D017780:Malaria Vaccines; D010961:Plasmodium / Q000276:immunology; D015800:Protozoan Proteins / Q000276:immunology; D016052:Protozoan Vaccines; D012547:Schistosoma / Q000276:immunology; D012552:Schistosomiasis / Q000517:prevention & control*; D014614:Vaccines, Synthetic
D015507:Drugs, Investigational; D017780:Malaria Vaccines; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D014614:Vaccines, Synthetic