title: Initial fluid management of diabetic ketoacidosis in children.
abstract: The purpose of this study was to review the emergency department management of children presenting in diabetic ketoacidosis (DKA) to determine if current recommendations for fluid therapy are practiced. A 5-year retrospective chart review was conducted of all pediatric patients admitted with DKA to the University of Alberta Hospital. Presenting clinical and laboratory data, the initial fluid therapy, and insulin dose were analyzed. The therapy was also compared between sites of initial presentation (primary, secondary, or tertiary hospital). A total of 49 cases of DKA in 37 patients were reviewed. There were no significant clinical or biochemical differences between patients presenting at the three levels of hospital. Forty-one cases (84%) were given a saline bolus and the mean fluid volume given by 1 hour was 18.3 mL/kg. In the first hour 82% of patients presenting at a primary or secondary centre and 67% of those at the tertiary centre received more than 10 mL/kg. This excessive fluid therapy was also evident after 4 hours. Fluid management of children in DKA is excessive and not in keeping with current recommendations. Education of emergency physicians is needed to reduce fluid therapy and the risk of neurologic complications.
authors.affiliation: Department of Pediatrics, University of Alberta, Edmonton, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Rutledge
authors.forename: R
authors.initials: R
authors.lastname: Couch
mesh_terms: D000416:Alberta; D001786:Blood Glucose; D002648:Child; D016883:Diabetic Ketoacidosis / Q000628:therapy*; D004636:Emergency Service, Hospital; D005440:Fluid Therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D012189:Retrospective Studies; D017693:Sodium Bicarbonate / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D017693:Sodium Bicarbonate