[Dynamics of neuroreceptor function in a chemical synapse].
A model for the dynamics of functioning of neuroreceptors in chemical synapses is proposed. It is shown that the functioning of a neuroreceptor by the action of mediator is determined by correlation of the mechanical elasticity of the receptor with its electrical polarizability and the presence of spiralized fragments. It is shown in terms of the quantum-mechanical approach that, as the charged groups of the mediator come close to the C-end of the neuroreceptor, a shift of potential surface occurs, which corresponds to the deformation of the receptor. The microscopic approach enables one to describe more exactly the dynamics of functioning of neuroreceptors than the macroscopic approach; however, its implementation requires the use of powerful computers. If only qualitative assessment is needed, the macroscopic approach would suffice. It is assumed that in terms of the model, the saltatory (jump-like) conduction of the spike along the axon can be explained.
Vasil'eva-Vashakmadze
N S
NS
Department of Physics, Dzhavakhishvili Tbilisi State University, Georgia.
D008962:Models, Theoretical; D011984:Sensory Receptor Cells / Q000502:physiology*; D013569:Synapses / Q000502:physiology*