Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK1195.
Using quantitative PET, the authors studied the binding of [11C]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [11C]PK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in [11C]PK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.
Pappata
S
S
INSERM U334, Service Hospitalier Frédéric Joliot, Orsay, France. pappata@shfj.cea.fr
Levasseur
M
M
Gunn
R N
RN
Myers
R
R
Crouzel
C
C
Syrota
A
A
Jones
T
T
Kreutzberg
G W
GW
Banati
R B
RB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000000981:diagnostic imaging* / Q000473:pathology*; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D007546:Isoquinolines; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000000981:diagnostic imaging* / Q000473:pathology*; D013787:Thalamic Nuclei / Q000000981:diagnostic imaging* / Q000473:pathology*; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D007546:Isoquinolines; C037850:PK 11195