title: Nitric oxide is involved in sustained and delayed cell death of rat retina following transient ischemia.
abstract: We have investigated the role of nitric oxide (NO) in the rat retina following ischemic injury induced by transient increase of intraocular pressure. The thickness of both the inner plexiform layer and inner nuclear layer decreased during early postischemic stages (up to 1 week). In late postischemic stages (2-4 weeks), the thickness of the outer nuclear layer (ONL) decreased markedly. Thus, mechanisms other than excitotoxic ones may contribute to postischemic retinal cell death. Treatment of rats with N(G)-nitro-L-arginine methyl ester, a nitric oxide synthase (NOS) inhibitor, significantly reduced ischemic damage. Our findings suggest that NO is involved in the mechanism of ischemic injury, and plays a key role in the delayed and sustained cell death in the ONL following transient retinal ischemia.
authors.affiliation: Department of Anatomy, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, 137-701, Seoul, South Korea.
authors.forename: W K
authors.initials: WK
authors.lastname: Ju
authors.forename: K Y
authors.initials: KY
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Park
authors.forename: D K
authors.initials: DK
authors.lastname: Park
authors.forename: C B
authors.initials: CB
authors.lastname: Park
authors.forename: S J
authors.initials: SJ
authors.lastname: Oh
authors.forename: J W
authors.initials: JW
authors.lastname: Chung
authors.forename: M H
authors.initials: MH
authors.lastname: Chun
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology / Q000627:therapeutic use; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D012160:Retina / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*
chemical_list: D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester