[Effect of piracetam on urea-induced myoclonus in rats].
Piracetam [2-oxo-1-pyrrolidineacetamide], a cyclic GABA, has been used in Europe for the treatment of patients with cognitive disorders. We investigated the effect of piracetam on urea-induced myoclonus in rats. Myoclonus was induced by intraperitoneal injection of 4.5 g/kg urea, and was recorded with EMG and video apparatus. The incidence of induced myoclonus decreased significantly by intraperitoneal injection of 300 mg/kg piracetam and oral administration of 0.3-10 mg/kg clonazepam. Furthermore, the combined application of 100 mg/kg piracetam and 0.03-0.1 mg/kg clonazepam was effective in ameliorating the myoclonus, although separate administrations were not effective. These findings suggest that piracetam is an effective drug for treating myoclonus, particularly when it is used in combination with clonazepam.
Nanri
M
M
Pharmacology Research Lab., Taiho Pharmaceutical Co. Ltd., Tokushima, Japan.
Yamamoto
A
A
Matsuura
N
N
D000818:Animals; D002998:Clonazepam / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D008297:Male; D009207:Myoclonus / Q000139:chemically induced / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010889:Piracetam / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014508:Urea
D018696:Neuroprotective Agents; D018697:Nootropic Agents; D002998:Clonazepam; D014508:Urea; D010889:Piracetam