IgA deficiency in Czech healthy individuals and selected patient groups.
BACKGROUND
Selective IgA deficiency (IgAD) is the most common immunoglobulin deficiency with a variety of clinical manifestations. The frequency of IgAD differs depending on the ethnic origin and clinical symptoms of investigated persons.


METHODS
The prevalence of IgAD (serum IgA level <0.05 g/l) was determined in 5,310 Czech blood donors, 10,326 patients who had undergone immunological investigation, and 246 first-degree relatives of IgAD and common variable immunodeficiency (CVID) patients.


RESULTS
IgAD was detected in 13 (1/408; 0.24%) of the blood donors. The prevalence of IgAD was increased both in children (48/3,113; 1.5%) and adults (33/3,824; 0.9%) referred for frequent respiratory tract infections (in both cases p<0.001) compared to the healthy population. The frequency of IgAD was 12/189 (6%) in first-degree relatives of IgAD patients and 9/57 (16%) in relatives of CVID patients, with the highest frequency observed in children of CVID patients.


CONCLUSIONS
The prevalence of IgAD in the Czech healthy population is comparable to that in other Caucasians. The frequency is increased in children with recurrent respiratory tract infections and especially in relatives of patients with immunoglobulin deficiencies.
Litzman
J
J
Department of Clinical Immunology and Allergology, Masaryk University, St. Anne Faculty Hospital, Brno, Czech Republic. Jlitzman@med.muni.cz
Sevcíková
I
I
Stikarovská
D
D
Pikulová
Z
Z
Pazdírková
A
A
Lokaj
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000276:immunology; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D007132:Immunoglobulin Isotypes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D010290:Parents; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000150:complications / Q000276:immunology; D044465:White People
D007132:Immunoglobulin Isotypes