Acute inhalation toxicity study of 2-fluoroacetamide in rats.
One of the most potent rodenticides is 2-fluoroacetamide (2-FA). Toxicity of this chemical is well documented. However, its inhalation toxicity data is not available in the literature. Hence, acute inhalation toxicity study was carried out by exposing male and female rats to aerosols of 2-FA at different concentrations for 4 h in a dynamically operated whole body inhalation exposure chamber. During and after the inhalation exposure the rats were less active, and showed mild tremors and convulsions. At higher concentrations the rats died after 2-3 days. The estimated 4-h LC50 for male and female rats was 136.6 and 144.5 mg.m-3 respectively. Exposure to 0.7 LC50 for 4 h duration showed an increase in the liver weight of male and female rats 7 days after exposure. Various haematological and biochemical variables determined were within the normal limits. However, histological findings showed injured lung as indicated by desquamation and necrosis of the epithelium of the respiratory tract. Marked hypertrophy of hepatocytes displaying strong acidophilic granulated cytoplasm was observed. Focal dilatation of renal proximal tubules in kidney with cytoplasmic vacuolation, and irregularly placed pyknotic nuclei were seen. The present study shows that 2-FA is a highly toxic chemical through the inhalation route based on the LC50 value. Consequently necessary precautions should be taken during its handling.
Singh
M
M
Defence Research and Development Establishment, Gwalior, India. drde@gwrl.dot.net.in
Vijayaraghavan
R
R
Pant
S C
SC
Sugendran
K
K
Kumar
P
P
Singh
R
R
Purnanand
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005463:Fluoroacetates / Q000008:administration & dosage / Q000633:toxicity*; D019570:Inhalation Exposure; D007928:Lethal Dose 50; D008168:Lung / Q000473:pathology; D008297:Male; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D012378:Rodenticides / Q000008:administration & dosage / Q000633:toxicity*
D005463:Fluoroacetates; D012378:Rodenticides; C007741:fluoroacetamide