title: New antifungal agents that inhibit the growth of Candida species: dichlorinated 8-quinolinols.
abstract: Five dichlorinated 8-quinolinols (2,5- 5,6-, 3,5-, 3,7-, and 4,5-dichloro-8-quinolinol) were tested against Candida albicans and C. tropicalis in Sabouraud dextrose broth with and without bovine serum. The 5,6-, 3,5-, and 3,7-dichloro-8-quinolinols proved to be more effective than the control, 5-fluorocytosine. In cytotoxicity tests employing baby hamster kidney (BHK) cells, all test agents proved to be more cytotoxic than the control. However, the minimum inhibitory concentration (MIC) of 3,5-dichloro-8-quinolinol to both fungi was only one tenth the cytotoxic dose, suggesting that the compound may be useful as a topical or systemic antifungal agent.
authors.affiliation: New York Botanical Garden, Harding Laboratory, Bronx 10458, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Lentz
authors.forename: H
authors.initials: H
authors.lastname: Gershon
authors.forename: H
authors.initials: H
authors.lastname: Marini
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000254:growth & development; D002460:Cell Line; D002739:Chloroquinolinols / Q000494:pharmacology*; D006224:Cricetinae; D008826:Microbial Sensitivity Tests; D013997:Time Factors; D018675:Toxicity Tests
chemical_list: D000935:Antifungal Agents; D002739:Chloroquinolinols