A new antiplasmodial coumarin from Toddalia asiatica roots.
A new antiplasmodial coumarin, 5,7-dimethoxy-8-(3'-hydroxy-3'methyl-1'-butene)-coumarin (1), has been isolated from the roots of Toddalia asiatica. This finding supports the traditional use of this plant for the treatment of malaria.
Oketch-Rabah
H A
HA
Department of Pharmacology and Pharmacognosy, Faculty of Pharmacy, College of Health Sciences, University of Nairobi, P.O. Box 19676, Nairobi, Kenya. heoketch@africaonline.co.ke
Mwangi
J W
JW
Lisgarten
J
J
Mberu
E K
EK
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D016488:Medicine, African Traditional; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
C426660:5,7-dimethoxy-8-(3'-hydroxy-3'-methyl-1'-butene)coumarin; D000962:Antimalarials; D003374:Coumarins; D010936:Plant Extracts; C030123:coumarin