Models for estimation of the (10)B concentration after BPA-fructose complex infusion in patients during epithermal neutron irradiation in BNCT.
OBJECTIVE
To create simple and reliable models for clinical practice for estimating the blood (10)B time-concentration curve after p-boronophenylalanine fructose complex (BPA-F) infusion in patients during neutron irradiation in boron neutron capture therapy (BNCT).


METHODS
BPA-F (290 mg BPA/kg body weight) was infused i.v. during two hours to 10 glioblastoma multiforme patients. Blood samples were collected during and after the infusion. Compartmental models and bi-exponential function fit were constructed based on the (10)B blood time-concentration curve. The constructed models were tested with data from six additional patients who received various amounts of infused BPA-F and data from one patient who received a one-hour infusion of 170 mg BPA/kg body weight.


RESULTS
The resulting open two-compartment model and bi-exponential function estimate the clearance of (10)B after 290 mg BPA/kg body weight infusion from the blood with satisfactory accuracy during the first irradiation field (1 ppm, i.e., 7%). The accuracy of the two models in predicting the clearance of (10)B during the second irradiation field are for two-compartment model 1.0 ppm (8%) and 0.2 ppm (2%) for bi-exponential function. The models predict the average blood (10)B concentration with an increasing accuracy as more data points are available during the treatment.


CONCLUSIONS
By combining the two models, a robust and practical modeling tool is created for the estimation of the (10)B concentration in blood after BPA-F infusion.
Ryynänen
P M
PM
Department of Physics, University of Helsinki, Helsinki, Finland.
Kortesniemi
M
M
Coderre
J A
JA
Diaz
A Z
AZ
Hiismäki
P
P
Savolainen
S E
SE
D001895:Boron / Q000097:blood*; D001896:Boron Compounds / Q000378:metabolism / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001932:Brain Neoplasms / Q000097:blood / Q000532:radiotherapy*; D005632:Fructose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use*; D005909:Glioblastoma / Q000097:blood / Q000532:radiotherapy*; D006801:Humans; D007554:Isotopes; D008954:Models, Biological; D011838:Radiation-Sensitizing Agents / Q000378:metabolism / Q000627:therapeutic use*; D011853:Radiobiology
C089739:4-boronophenylalanine-fructose; D001896:Boron Compounds; D007554:Isotopes; D011838:Radiation-Sensitizing Agents; D005632:Fructose; D001895:Boron