Frequency, risk factors, and clinical outcomes of left ventricular assist device-associated ventricular thrombus.
A retrospective, transesophageal study of 51 consecutive patients receiving a left ventricular (LV) assist device (AD) over a 2-year period showed that LVAD-associated LV thrombosis (16%) was predicted by acute myocardial infarction, atrial cannulation, and postimplantation bleeding, and was associated with a fourfold increased risk of stroke compared with patients without thrombosis. LV cannulation, when using short-term LVADs, may decrease the incidence of LV thrombosis, and early transition to Heartmate-LVAD support may improve outcome.
Reilly
M P
MP
Department of Medicine, University of Pennsylvania Health System, Philadelphia 19014, USA. muredach@spirit.gcrc.upenn.edu.
Wiegers
S E
SE
Cucchiara
A J
AJ
O'Hara
M L
ML
Plappert
T J
TJ
Loh
E
E
Acker
M A
MA
St John Sutton
M
M
D000368:Aged; D000704:Analysis of Variance; D003327:Coronary Disease / Q000150:complications / Q000628:therapy; D017548:Echocardiography, Transesophageal; D004868:Equipment Failure; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D006352:Heart Ventricles; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D016896:Treatment Outcome