Metabolites of Colletotrichum gloeosporioides, an endophytic fungus in Artemisia mongolica.
A new antimicrobial metabolite, named colletotric acid (1), was isolated from a liquid culture of Colletotrichum gloeosporioides, an endophytic fungus colonized inside the stem of Artemisia mongolica. The structure was determined using spectroscopic methods (EIMS and FABMS,(1)H and (13)C NMR, (1)H-(1)H COSY, HMBC, and HMQC). Compound 1 inhibited the growth of Bacillus subtilis, Staphylococcusaureus, and Sarcina lutea with minimal inhibitory concentrations (MICs) of 25, 50, and 50 microg/mL, respectively, and the crop pathogenic fungus Helminthosporium sativum (MIC: 50 microg/mL).
Zou
W X
WX
Institute of Functional Biomolecule, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, People's Republic of China.
Meng
J C
JC
Lu
H
H
Chen
G X
GX
Shi
G X
GX
Zhang
T Y
TY
Tan
R X
RX
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D019306:Artemisia / Q000737:chemistry / Q000382:microbiology*; D001419:Bacteria / Q000187:drug effects; D020231:Colletotrichum / Q000737:chemistry / Q000378:metabolism*; D005285:Fermentation; D062385:Hydroxybenzoates; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D062385:Hydroxybenzoates; C419724:colletotric acid