title: Substituted guanidines: introducing diversity in combinatorial chemistry.
abstract: The guanidine moiety is an important motif present in many biologically active compounds. Fully substituted guanidines are of key importance for the development of bioactive molecules. The present paper reports on an efficient procedure for the direct solid-phase conversion of amines to fully substituted guanidines under very mild conditions.
authors.affiliation: Departament de Química Orgànica, Universitat de Barcelona, 08028 Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: del Fresno
authors.forename: A
authors.initials: A
authors.lastname: El-Faham
authors.forename: L A
authors.initials: LA
authors.lastname: Carpino
authors.forename: M
authors.initials: M
authors.lastname: Royo
authors.forename: F
authors.initials: F
authors.lastname: Albericio
mesh_terms: D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D006146:Guanidines; D007202:Indicators and Reagents