Production of LLU-alpha following an oral administration of gamma-tocotrienol or gamma-tocopherol to rats.
An oral administration of gamma-tocotrienol (gamma-T3) or gamma-tocopherol (gamma-Toc) to male rats caused an increase of the concentration of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman (LLU-alpha, gamma-CEHC), a natriuretic compound, in plasma with a T(max) of 9 h. The configuration at C-2 of LLU-alpha produced from gamma-T3 or gamma-Toc was assigned as S-form by an HPLC equipped with a chiral column. These data indicated that LLU-alpha was produced not only from gamma-Toc but also gamma-T3, without racemization at C-2 in rats.
Hattori
A
A
Department of Bio-Analytical Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Fukushima
T
T
Yoshimura
H
H
Abe
K
K
Imai
K
K
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002839:Chromans / Q000097:blood / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011422:Propionates / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology*; D024504:gamma-Tocopherol / Q000494:pharmacology*
D000975:Antioxidants; D002839:Chromans; D011422:Propionates; D014810:Vitamin E; C107690:2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman; C013649:plastochromanol 8; D024504:gamma-Tocopherol