The expression and function of Epstein-Barr virus encoded latent genes.
The association of Epstein-Barr virus (EBV) with various malignancies is well established but the pattern of EBV latent gene expression in these different tumours is variable, reflecting distinct aspects of the virus-cell interaction. These different forms of EBV latency are associated with phenotypic variation and highlight the influence of EBV latent proteins on cell growth and survival. The EBV latent proteins have distinct functions associated with the maintenance of EBV infection and the control of various signalling and transcriptional pathways that facilitate the proliferation and survival of infected cells. Understanding the function of these EBV latent proteins will not only provide insight into the mechanisms governing fundamental cell processes but will also identify targets for novel treatment.
Young
L S
LS
CRC Institute for Cancer Studies, University of Birmingham Medical School, UK. L.S.Young@bham.ac.uk
Dawson
C W
CW
Eliopoulos
A G
AG
D002450:Cell Communication / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002472:Cell Transformation, Viral / Q000235:genetics; D015870:Gene Expression; D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000503:physiopathology; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D017735:Virus Latency / Q000235:genetics*