Beneficial effects of ischemic preconditioning on right ventricular function after coronary artery bypass grafting.
BACKGROUND
Preservation of right ventricular myocardium is unsatisfactory in patients with critical stenosis or occlusion of the right coronary artery. The aim of this study was to investigate whether ischemic preconditioning (IP) improved the recovery of right ventricular function after coronary artery bypass grafting.


METHODS
Forty patients with three-vessel disease who had coronary artery bypass grafting were randomly assigned to the IP group (n = 20) or control group (n = 20). In the IP group, two cycles of two minutes of ischemia after three minutes of reperfusion were given before cross-clamping. Hemodynamic data were collected. Right ventricular ejection fraction was measured by thermodilution.


RESULTS
Right ventricular ejection fraction and right ventricular systolic volume index were decreased post-operatively (lowest value at 6 hours postoperatively). The changes in right ventricular ejection fraction were significantly milder in the IP group postoperatively (p = 0.012). The decrease in right ventricular systolic volume index postoperatively was also less in IP patients (p = 0.002). Fewer inotropic drugs were used in the IP group compared with controls.


CONCLUSIONS
Ischemic preconditioning had a myocardial protective effect on recovery of right ventricular contractility in patients who had coronary artery bypass grafting.
Wu
Z K
ZK
Department of Anesthesiology and Intensive Care, Tampere University Hospital, Finland.
Tarkka
M R
MR
Pehkonen
E
E
Kaukinen
L
L
Honkonen
E L
EL
Kaukinen
S
S
D000368:Aged; D002306:Cardiac Volume; D002316:Cardiotonic Agents / Q000008:administration & dosage; D001026:Coronary Artery Bypass / Q000379:methods*; D005260:Female; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011184:Postoperative Period; D013318:Stroke Volume; D013599:Systole / Q000502:physiology; D016278:Ventricular Function, Right / Q000502:physiology*
D002316:Cardiotonic Agents