title: Synthesis of tri- and tetrasubstituted furans catalyzed by trifluoroacetic acid
abstract: Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-butyl acetoacetate with an alpha-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA). A second alkylation of the intermediate followed by treatment with trifluoroacetic acid provides access to disubstituted 2-methylfurans.
authors.affiliation: Institute of Chemistry, University of Neuchatel, Avenue de Bellevaux 51, CH-2007 Neuchatel, Switzerland.
authors.initials: F
authors.lastname: Stauffer
authors.initials: R
authors.lastname: Neier