title: Radiation Complications Following Breast Conserving Therapy.
abstract: BACKGROUND: Breast conserving therapy is being established as a standard therapeutic procedure for early breast cancer in Japan. However, the indications of radiotherapy and a standardized therapeutic procedure have not been established yet. In this study, complications following radiotherapy were evaluated in patients who had previously undergone breast conserving therapy at Tokushima University Hospital. METHODS From October 1989 to March 1996, 60 women with stage I or II breast cancer underwent radiation therapy after breast conserving surgery, and all patients were followed-up for a median of 27 months. Radiation morbidity scoring of the breast and adjacent organs was performed using the toxity criteria of the Radiation Therapy Oncology Group (RTOG) and European Organization for Research andTreatment of Cancer (EORTC). RESULTS: Only 1 patient developed local recurrence, and no distant metastasisor death was observed. The cause of recurrence in 1 case was considered to be due to extended intraductal component. Although transient dermal reaction was induced by irradiation of the breast, no side effects that may cause cosmetic problems were found. No serious radiation complications were found in the lungs, ribs, heart or other adjacent organs. CONCLUSION: The adverse reactions caused by irradiation does not reduce the merit of combined use of radiation therapy in breast conserving therapy, and therefore, are not the hesitation factor in application of radiotherapy.
authors.affiliation: Department of Radiology, University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
authors.initials: H
authors.lastname: Ikushima
authors.initials: Y
authors.lastname: Takegawa
authors.initials: H
authors.lastname: Yasuda
authors.initials: Y
authors.lastname: Makimoto
authors.initials: K
authors.lastname: Matsuzaki
authors.initials: K
authors.lastname: Kashihara
authors.initials: J
authors.lastname: Ueno
authors.initials: M
authors.lastname: Sasa
authors.initials: T
authors.lastname: Morimoto
authors.initials: H
authors.lastname: Nishitani