title: Cell-cycle regulation in immunity, tolerance and autoimmunity.
abstract: To trigger an effective immune response, lymphocytes must proliferate. In addition to their direct involvement in cell-cycle progression, cell-cycle regulators might thus control immune functions. Recent evidence suggests that these regulators are essential for T-cell function; we argue that their study will provide clues for dissecting anergy and tolerance mechanisms, as well as for intervention in autoimmune diseases.
authors.affiliation: Dept. of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, Madrid, Spain. dbalomenos@cnb.uam.es
authors.forename: D
authors.initials: D
authors.lastname: Balomenos
authors.forename: C
authors.initials: C
authors.lastname: Martínez-A
mesh_terms: D000818:Animals; D015551:Autoimmunity; D002453:Cell Cycle / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D008213:Lymphocyte Activation; D008954:Models, Biological