CR377, a new pentaketide antifungal agent isolated from an endophytic fungus.
Cultures of endophytic fungi collected in the Guanacaste Conservation Area of Costa Rica were screened for antifungal activity. CR377, a new pentaketide antifungal agent, was isolated from the culture broth of a fungus, CR377 (Fusarium sp.), that showed potent activity against Candida albicans in this assay. The structure of CR377 was established using 1- and 2-D NMR and HRFABMS.
Brady
S F
SF
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
Clardy
J
J
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D005670:Fusarium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000935:Antifungal Agents; C416587:CR 377; D011753:Pyrones