Two cases of primary open angle glaucoma with serum autoantibody against retinal ganglion cells.
OBJECTIVE
To present two cases of primary open angle glaucoma (POAG) with serum autoantibody against retinal 25 kDa or 50 kDa antigen.


METHODS
Ocular examinations were performed on a 60-year-old man (case 1) and a 74-year-old woman (case 2). We also performed serological and immunological examinations including Western blot analysis and immunocytochemical analysis.


RESULTS
In Western blot analysis, they were found to have serum autoantibody against retinal 25 kDa or 50 kDa antigen, and immunocytochemical analysis revealed that retinal ganglion cell layers were specifically labeled by each patient's IgG.


CONCLUSIONS
We report two interesting cases of POAG with serum autoantibody against retinal 25 kDa or 50 kDa antigen.
Ikeda
Y
Y
Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Ohguro
H
H
Maruyama
I
I
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D015153:Blotting, Western; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009898:Optic Disk / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000276:immunology*; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity; D014794:Visual Fields
D001323:Autoantibodies; D001324:Autoantigens