[Chloroquine-induced drug hypersensitivity alveolitis].
This case history presents a 41-years-old man with chronic discoid erythematosus who was treated with chloroquine. After 2 weeks of treatment he developed dyspnea, purulent sputum, high fever, diffuse papular rash, and diffuse peripheral homogeneous infiltrates on chest x-ray. Rapid recovery occurred after discontinuing chloroquine. Subsequent peroral provocation with chloroquine caused symptoms suggestive of hypersensitivity pneumonitis. Analysis of bronchoalveolar lavage fluid showed eosinophilia and a reduced CD4/CD8 ratio. Although treatment with chloroquine is often complicated by side effects, in a literature search we could not find any report on acute pneumonitis.
Mitja
K
K
Universitätskrankenhaus für Pneumologie und Allergologie, Golnik/Slovenia.
Izidor
K
K
Music
E
E
D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016516:CD4-CD8 Ratio; D002738:Chloroquine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000276:immunology; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy*; D008297:Male
D018501:Antirheumatic Agents; D002738:Chloroquine