title: [Comparison of the activity of different macrolides on strains of Haemophilus influenzae].
abstract: In this study we evaluated the activity of macrolides and b-lactam antimicrobials on Haemophilus influenzae isolated in 1998 in eight Spanish cities. A total of 174 clinical isolates were examined. Overall, 29% of the isolates were found to produce b-lactamase. Azithromycin was the most active of the macrolides tested in this study (MIC90 of 4 mg/l); no azithromycin-resistant strains were found. Ampicillin resistance was 29%. We found one strain intrinsically resistant to beta-lactam agents (0.65% overall); and two beta-lactamase-positive strains that were resistant to amoxicillin-clavulanic acid (1.2%). The presence of these strains, while uncommon at present, makes it necessary to test the activity of antimicrobial drugs on H. influenzae.
authors.affiliation: Departamento de Microbiología, Hospital Universitario Virgen Macarena, Sevilla.
authors.forename: J A
authors.initials: JA
authors.lastname: Ramírez de Arellano
authors.forename: E J
authors.initials: EJ
authors.lastname: Perea
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006192:Haemophilus Infections / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D013030:Spain; D001618:beta-Lactamases / Q000032:analysis / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D001618:beta-Lactamases