[Nostalgic review of one student of Prof. Tsuda about natural product, carbanion, thiazoline and beta-lactam chemistry].
This article describes the works of one of Tsuda's students who owes their performance to him through the long-term, direct and indirect influence of the Tsuda school, especially supervised by him during his very last period as a Professor at the University of Tokyo. They consist of i) natural product chemistry, i.e. Siccanin and related congeners, ii) carbanion chemistry, i.e. iodomethylation (C1) and trans-iodopropenylation (C3) reactions using thiazoline derivatives and their synthetic application, and iii) beta-lactam chemistry, i.e. 1,3-dipoler cycloaddition reaction of iminochloride of penicillin, new beta-lactam ring synthesis, synthesis of carbapenem derivatives including microbial hydration and stereo-specific 1 beta-methyl carbapenem synthesis.
Hirai
K
K
Research Institute, Sankyo Co., Ltd., Tokyo, Japan.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry; D014169:Transformation, Bacterial; D014966:Xanthenes / Q000737:chemistry; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D013844:Thiazoles; D014966:Xanthenes; D047090:beta-Lactams; C001795:siccanin