A study of hemorheological behaviour for patients with Alzheimer's disease at the early stages.
To evaluate the change of hemorheological indexes for patients with Alzheimer's disease (AD) at the early stages and to discuss effects of these changes on AD, high shear value of whole blood viscosity (etabh), reduced high shear value of whole blood viscosity (retabh), low shear value of whole blood viscosity (etabl), reduced low shear, value of whole blood viscosity (retabl), KT value of whole blood viscosity, hematocrit (HCT) and blood plasma viscosity (etaP) were measured in 31 patients with probable AD at the early stages and 33 age-matched healthy subjects. There were significant differences of all hemorheological indexes between AD group and control group except HCT. Step discriminant analysis revealed 81.25% of overall group-classified accuracy in a hemorheological discriminant function consisting of etabl, retabl, retabh and HCT. Significant difference of hemorheological indexes existed between AD and age-matched healthy control subjects. The results showed that measurement of hemorheological indexes could be used as one of reference standards of diagnosis in AD.
Wen
Z
Z
Department of Medical Physics, Beijing Medical University, PR China. rheol@mail.bjmu.edu.cn
Xie
J
J
Guan
Z
Z
Sun
D
D
Yao
W
W
Chen
K
K
Yan
Z Y
ZY
Mu
Q
Q
D000368:Aged; D000375:Aging / Q000097:blood; D000544:Alzheimer Disease / Q000097:blood*; D001809:Blood Viscosity; D018450:Disease Progression; D004903:Erythrocyte Aggregation; D004907:Erythrocyte Deformability; D005260:Female; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged