Serial volumetric intravascular ultrasound analysis of the efficacy of beta irradiation in preventing recurrent in-stent restenosis.
We compared postintervention and follow-up intravascular ultrasound findings of 25 patients from the beta-Washington Radiation for InStent restenosis Trial (in which all patients received radiation) and 75 patients from the Washington Radiation for InStent restenosis Trial (in which patients were randomized to gamma irradiation). The decrease in lumen volume was similar for beta versus gamma and less in both gamma versus placebo and beta versus placebo; the increase in intimal hyperplasia volume was similar for beta versus gamma and greater in both beta versus placebo and gamma versus placebo.
Bhargava
B
B
Intravascular Ultrasound Imaging and Cardiac Catheterization Laboratories, Washington Hospital Center, DC, USA.
Mintz
G S
GS
Mehran
R
R
Lansky
A J
AJ
Weissman
N J
NJ
Walsh
C
C
Chan
R C
RC
Waksman
R
R
D001610:Beta Particles / Q000627:therapeutic use*; D001918:Brachytherapy; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000517:prevention & control / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D012008:Recurrence; D015607:Stents; D013997:Time Factors; D018084:Ultrasonography, Interventional; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
D007496:Iridium Radioisotopes; D015021:Yttrium Radioisotopes