Unsaturated fatty acids inhibit sterol regulatory element-dependent gene expression: a potential mechanism contributing to hypertriglyceridemia in fat-restricted diets.
Deckelbaum
R J
RJ
Institute of Human Nutrition and Department of Pediatrics, Columbia University, New York, New York 10032, USA. rjd20@columbia.edu
Johnson
R A
RA
Worgall
T S
TS
D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D018752:Diet, Fat-Restricted / Q000009:adverse effects*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D015228:Hypertriglyceridemia / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1; D013261:Sterols / Q000378:metabolism*; D014157:Transcription Factors; D014280:Triglycerides / Q000096:biosynthesis
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D005231:Fatty Acids, Unsaturated; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D013261:Sterols; D014157:Transcription Factors; D014280:Triglycerides