New stereoselective intramolecular
Efficient 1,4-asymmetric induction has been achieved in the highly stereocontrolled intramolecular [2 + 2] cycloadditions between ketenimines and imines, leading to 1,2-dihydroazeto[2, 1-b]quinazolines. The chiral methine carbon adjacent to the iminic nitrogen controls the exclusive formation of the cycloadducts with relative trans configuration at C2 and C8. The stepwise mechanistic model, based on theoretical calculations, fully supports the stereochemical outcome of these cycloadditions.
Alajarin
M
Farmazi Fakultatea, Euskal Herriko Unibertsitatea, P. K. 450, 01080 Vitoria-Gasteiz, Spain.
Vidal
A
Tovar
F
Ramirez De Arellano MC
Cossio
FP
Arrieta
A
Lecea
B