A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells.
A new indanone (1) has been isolated from the filamentous marine cyanobacterium Lyngbya majuscula, and its structure determined spectroscopically. Vascular endothelial growth factor (VEGF) is an important regulator of tumor angiogenesis. Compound 1 inhibits hypoxia-induced activation of the VEGF gene promoter in Hep3B human liver tumor cells, in vitro.
Nagle
D G
DG
Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, Mississippi 38677-1848, USA.
Zhou
Y D
YD
Park
P U
PU
Paul
V J
VJ
Rajbhandari
I
I
Duncan
C J
CJ
Pasco
D S
DS
D015687:Cell Hypoxia; D000458:Cyanobacteria / Q000737:chemistry*; D016228:Endothelial Growth Factors / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D006801:Humans; D007189:Indans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008222:Lymphokines / Q000235:genetics; D011401:Promoter Regions, Genetic; D014407:Tumor Cells, Cultured; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D007189:Indans; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C013352:indacrinone