title: Clinicopathological studies of a patient with adult T-cell leukemia and pseudogynecomasty.
abstract: We present a rare case of adult T cell leukemia/lymphoma (ATL) in which leukemic T cells expressed CD4 and CD25 surface antigens and infiltrated mammary glands during clinical course of the disease. A 40-year-old male was admitted with long-standing skin lesions and leukocytosis. Peripheral blood lymphocytes were highly pleomorphic and presented CD2, CD4, CD25, CD38 membrane surface antigens. The patient proved to be seropositive for human T-cell lymphotropic virus type I (HTLV-I) antibodies. Monoclonal expansion of lymphoid cells integrated with HTLV-I genome was observed, and the diagnosis of ATL chronic type was made. He underwent a chemotherapy regimen, and skin lesions and leukocytosis improved markedly. He progressed with an indolent clinical course of ATL, when he was admitted with bilateral hyperplasia of breast, recurrent skin lesions, and leukocytosis. Breast biopsy revealed bilateral gynecomasty, extensive leukemic infiltration of typical ATL cells in the mammary glands, and the presence of mammary epithelial cells productively infected with HTLV-I. This is the first report describing invasion of the mammary tissue with HTLV-I-transformed T-cells and HTLV-I-associated breast disease.
authors.affiliation: Department of Hematology, Hemocentro de Pernambuco, Recife, Brazil.
authors.forename: P
authors.initials: P
authors.lastname: Loureiro
authors.forename: S O
authors.initials: SO
authors.lastname: Southern
authors.forename: P J
authors.initials: PJ
authors.lastname: Southern
authors.forename: M S
authors.initials: MS
authors.lastname: Pombo-de-Oliveira
mesh_terms: D001940:Breast / Q000737:chemistry; D006177:Gynecomastia / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged