title: Overexpression of cyclin D1 occurs frequently in human pancreatic endocrine tumors.
abstract: The molecular pathogenesis of human pancreatic endocrine tumors (PETs) is poorly understood. Three independent animal models have pointed to the pivotal role of the G1/S cell cycle transition in pancreatic endocrine cell proliferation. We thus hypothesized that the cell cycle regulator cyclin D1 may contribute to the pathogenesis of human PETs. Overexpression of cyclin D1 was identified in 43% of cases, and no correlation was observed with clinical phenotype. The novel observation of frequent overexpression of cyclin D1 suggests that this established oncogene may be implicated in the pathogenesis of human PETs. The absence of detectable alterations in cyclin D1 genomic structure suggests that the mechanism for its oncogenic activation in PETs may be transcriptional or posttranscriptional.
authors.affiliation: Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. d_chung@helix.mgh.harvard.edu
authors.forename: D C
authors.initials: DC
authors.lastname: Chung
authors.forename: S B
authors.initials: SB
authors.lastname: Brown
authors.forename: F
authors.initials: F
authors.lastname: Graeme-Cook
authors.forename: M
authors.initials: M
authors.lastname: Seto
authors.forename: A L
authors.initials: AL
authors.lastname: Warshaw
authors.forename: R T
authors.initials: RT
authors.lastname: Jensen
authors.forename: A
authors.initials: A
authors.lastname: Arnold
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D019938:Cyclin D1 / Q000032:analysis / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000235:genetics; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology / Q000601:surgery
chemical_list: D019938:Cyclin D1