In vitro percutaneous absorption models.
In vitro skin absorption studies are commonly used to estimate in vivo skin absorption in topical safety and efficacy evaluations. In vitro studies are more economical and result in minimization or elimination of the use of animals.
Bronaugh
R L
RL
Office of Cosmetics and Colors, Food and Drug Administration, Laurel, Maryland 20708, USA. rbronaug@CFSAN.fda.gov
D000279:Administration, Cutaneous; D000818:Animals; D002021:Buffers; D002470:Cell Survival / Q000187:drug effects; D004058:Diffusion; D006801:Humans; D066298:In Vitro Techniques; D012867:Skin / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D012869:Skin Absorption / Q000502:physiology*
D002021:Buffers