title: Effect of Chlamydia trachomatis infection on atherosclerosis in apolipoprotein E-deficient mice.
abstract: We have previously demonstrated that Chlamydia pneumoniae accelerates plaque formation in apolipoprotein E-deficient (ApoE(-/-)) mice following intranasal inoculations. In this study, we evaluated the effect of respiratory tract infection with Chlamydia trachomatis on the progression of atherosclerosis in ApoE(-/-) mice. The study showed that in contrast to infection with Chlamydia pneumoniae, infection of the lung and aorta with C. trachomatis was mild and transient and did not significantly accelerate plaque development.
authors.affiliation: Department of Pathobiology, University of Washington, Seattle, Washington 98195, USA.
authors.forename: E
authors.initials: E
authors.lastname: Blessing
authors.forename: S
authors.initials: S
authors.lastname: Nagano
authors.forename: L A
authors.initials: LA
authors.lastname: Campbell
authors.forename: M E
authors.initials: ME
authors.lastname: Rosenfeld
authors.forename: C C
authors.initials: CC
authors.lastname: Kuo
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001057:Apolipoproteins E / Q000172:deficiency*; D001161:Arteriosclerosis / Q000209:etiology*; D002690:Chlamydia Infections / Q000150:complications*; D002692:Chlamydia trachomatis; D016993:Chlamydophila pneumoniae; D006801:Humans; D008297:Male; D051379:Mice; D016133:Polymerase Chain Reaction
chemical_list: D000907:Antibodies, Bacterial; D001057:Apolipoproteins E