title: [The interactive determination of the mathematical model parameters for the planning of the radiation therapy of malignant tumors. 2. A method of adjusting the mathematical model parameters for calculating the tolerance doses and probabilities of the occurrence of radiation complications in body organs and tissues].
abstract: To enhance the accuracy of calculation of tolerance doses, adequate doses and the likelihood of radiation complications in normal organs and tissues, a method has been developed for local model parameter adjustment (LMPA) by using mathematical models. It includes the analysis of the structure of a mathematical model, the systematization of clinical data and their goal-oriented use for model adjustment. The necessity of developing a new research line (LMPA) is determined by the complexity of the irradiated organism as a system and by the attempts to take into account the impact of the system on the parameters of mathematical models. LMPA can be considered to generalize determination of the parameters of mathematical models or their directed (interactive) determination. The strategy of using LMPA, which is based on the preset radiation treatment protocol and its respective dosage distributions in normal organs and tissues, is described. The efficiency of LMPA is shown to depend on the volume and relevance of clinical data that the radiological therapist has at his disposal.
authors.forename: L Ia
authors.initials: LIa
authors.lastname: Klepper
mesh_terms: D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000532:radiotherapy*; D011336:Probability; D011832:Radiation Injuries / Q000517:prevention & control*; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000706:statistics & numerical data