title: Hantavirus pulmonary syndrome associated with Monongahela virus, Pennsylvania.
abstract: The first two recognized cases of rapidly fatal hantavirus pulmonary syndrome in Pennsylvania occurred within an 8-month period in 1997. Illness in the two patients was confirmed by immunohistochemical techniques on autopsy material. Reverse transcription-polymerase chain reaction analysis of tissue from one patient and environmentally associated Peromyscus leucopus (white-footed mouse) identified the Monongahela virus variant. Physicians should be vigilant for such Monongahela virus-associated cases in the eastern United States and Canada, particularly in the Appalachian region.
authors.affiliation: Lehigh Valley Hospital, Allentown, Pennsylvania, USA. luther.rhodes@lvh.com
authors.forename: L V
authors.initials: LV
authors.lastname: Rhodes
authors.forename: C
authors.initials: C
authors.lastname: Huang
authors.forename: A J
authors.initials: AJ
authors.lastname: Sanchez
authors.forename: S T
authors.initials: ST
authors.lastname: Nichol
authors.forename: S R
authors.initials: SR
authors.lastname: Zaki
authors.forename: T G
authors.initials: TG
authors.lastname: Ksiazek
authors.forename: J G
authors.initials: JG
authors.lastname: Humphreys
authors.forename: J J
authors.initials: JJ
authors.lastname: Freeman
authors.forename: K R
authors.initials: KR
authors.lastname: Knecht
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D018778:Hantavirus Infections / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000821:virology; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D010414:Pennsylvania; D010542:Peromyscus / Q000821:virology