[Cell transplantation therapy for Parkinson's disease].
We found that Parkinson's disease(PD) patients receiving autotransplants of the cervical sympathetic ganglia show a significant improvement in the parkinsonian symptoms with a consequent reduction in the daily intake of levodopa. The grafting procedure have recently been modified to further enhance the efficacy of the transplantation. Thus, in order to increase the amount of donor tissue we opted for the endoscopically excised thoracic sympathetic ganglia as a donor. With the aid of CT-guided stereotaxic surgery, we unilaterally placed one transplant deposit in the caudate head and three deposits in the putamen. Four patients that had received the grafts were followed with antiparkinsonian medication being unchanged at least one year postgrafting. Although no patients exhibited a substantial improvement in motor performance rated in either "on" or "off" phase, the awake time spent in "off" phase was reduced by 30-40% in all the patients. In two patients, dyskinesia in "on" phase was also attenuated. Our new transplantation paradigm is encouraging and deserves further investigation.
Nakao
N
N
Department of Neurological Surgery, Wakayama Medical College.
Uematsu
Y
Y
Itakura
T
T
D017690:Cell Transplantation / Q000379:methods*; D002986:Clinical Trials as Topic; D004409:Dyskinesia, Drug-Induced / Q000601:surgery; D005728:Ganglia, Sympathetic / Q000166:cytology*; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects; D010300:Parkinson Disease / Q000601:surgery*; D013238:Stereotaxic Techniques; D014182:Transplantation, Autologous
D007980:Levodopa