title: A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types.
abstract: Human papillomavirus (HPV)-16 causes about half the cases of cervical cancer worldwide and is the focus of HPV vaccine development efforts. Systematic data are lacking as to whether the prevention of HPV-16 could affect the equilibrium of infection with other HPV types and thus alter the predicted impact of vaccination on the occurrence of cervical neoplasia. Therefore, the associations of HPV-16 detection with subsequent acquisition of other HPV types and with the persistence of concomitantly detected HPV types were examined prospectively among 1124 initially cytologically normal women. Preexisting HPV-16 was generally associated with an increased risk for subsequent acquisition of other types. HPV-16 did not affect the persistence of concomitant infections, regardless of type. These findings suggest that the prevention or removal of HPV-16 is not likely to promote the risk of infection with other types, a theoretical concern with current vaccination efforts.
authors.affiliation: Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. liaw2+@pitt.edu
authors.forename: K L
authors.initials: KL
authors.lastname: Liaw
authors.forename: A
authors.initials: A
authors.lastname: Hildesheim
authors.forename: R D
authors.initials: RD
authors.lastname: Burk
authors.forename: P
authors.initials: P
authors.lastname: Gravitt
authors.forename: S
authors.initials: S
authors.lastname: Wacholder
authors.forename: M M
authors.initials: MM
authors.lastname: Manos
authors.forename: D R
authors.initials: DR
authors.lastname: Scott
authors.forename: M E
authors.initials: ME
authors.lastname: Sherman
authors.forename: R J
authors.initials: RJ
authors.lastname: Kurman
authors.forename: A G
authors.initials: AG
authors.lastname: Glass
authors.forename: S M
authors.initials: SM
authors.lastname: Anderson
authors.forename: M
authors.initials: M
authors.lastname: Schiffman
mesh_terms: D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000821:virology*; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000517:prevention & control; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral