Concurrent choroidal melanoma in son and father.
OBJECTIVE
To report the concurrent occurrence of choroidal melanoma in a son and father.


METHODS
Case reports. The likelihood of familial occurrence of uveal melanoma in which father and son are affected was estimated using the principles of probability.


RESULTS
Unilateral choroidal melanoma was diagnosed in a 41-year-old man. Three months later, his 68-year-old father presented with a pigmented choroidal mass that greatly increased in size during the next 6 months and was diagnosed a choroidal melanoma. No personal or family history of atypical moles, cutaneous melanoma, or other malignancy existed. The likelihood of familial occurrence of uveal melanoma using principles of probability was estimated to be 1 in 10 million.


CONCLUSIONS
Considering the low prevalence of uveal melanoma in the general population, the likelihood of uveal melanoma occurring in a family setting is remote.
Singh
A D
AD
Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Eyetumors@AOL.com
Demirci
H
H
Shields
C L
CL
Shields
J A
JA
Smith
A F
AF
D000328:Adult; D000368:Aged; D001918:Brachytherapy; D002830:Choroid Neoplasms / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D005654:Fundus Oculi; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D010375:Pedigree; D011336:Probability
D007457:Iodine Radioisotopes