title: Proteomics: new perspectives, new biomedical opportunities.
abstract: Proteomics-based approaches, which examine the expressed proteins of a tissue or cell type, complement the genome initiatives and are increasingly being used to address biomedical questions. Proteins are the main functional output, and the genetic code cannot always indicate which proteins are expressed, in what quantity, and in what form. For example, post-translational modifications of proteins, such as phosphorylation or glycosylation, are very important in determining protein function. Similarly, the effects of environmental factors or multigenic processes such as ageing or disease cannot be assessed simply by examination of the genome alone. This review describes the underlying technology and illustrates several areas of biomedical research, ranging from pathogenesis of neurological disorders to drug and vaccine design, in which potential clinical applications are being explored.
authors.affiliation: ICRF Cancer Medicine Research Unit, St James's University Hospital, Leeds, UK. r.banks@leeds.ac.uk
authors.forename: R E
authors.initials: RE
authors.lastname: Banks
authors.forename: M J
authors.initials: MJ
authors.lastname: Dunn
authors.forename: D F
authors.initials: DF
authors.lastname: Hochstrasser
authors.forename: J C
authors.initials: JC
authors.lastname: Sanchez
authors.forename: W
authors.initials: W
authors.lastname: Blackstock
authors.forename: D J
authors.initials: DJ
authors.lastname: Pappin
authors.forename: P J
authors.initials: PJ
authors.lastname: Selby
mesh_terms: D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007256:Information Systems; D011499:Protein Processing, Post-Translational; D020543:Proteome / Q000032:analysis* / Q000235:genetics; D012106:Research
chemical_list: D020543:Proteome