The vascular endothelial system in the pathogenesis of inflammation and systemic rheumatic diseases: relation to the neuroendocrine system.
There is no doubt that the VES plays a central role in the pathogenesis of immune-mediated and inflammatory conditions. Equally, there is no doubt about the strong influence played by the neuroendocrine-immune system on the pathophysiology and homeostasis of the VES. Nevertheless, much remains to be done to unravel the precise mechanisms by which these systems interact in determining the microvascular dysfunction associated with chronic immune-mediated inflammation.
Pitzalis
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Rheumatology Unit, Guy's, St. Thomas, and King's College, School of Medicine and Dentistry, London, England.
Koch
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D000728:Androgens / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000276:immunology* / Q000502:physiology; D004967:Estrogens / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D009490:Neurosecretory Systems / Q000502:physiology*; D012216:Rheumatic Diseases / Q000276:immunology / Q000503:physiopathology*
D000728:Androgens; D004967:Estrogens; D005938:Glucocorticoids