[Use of high doses of growth hormone in children with short body height secondary to an deficient secretion of this hormone].
Three groups of children with short stature secondary to growth hormone deficiency were treated for 4 years with recombinant growth hormone according to 3 regimen: 0.7 u/kg/week, 1.4 u/kg/week and 2.1 u/kg/week for 2 years, 0.7 u/kg/week the 2 following years. Catch up growth at 4 years was respectively 1.5 +/- 0.7 SD in the group 0.7; 2.5 +/- 0.9 SD in the group 1.4; 2.3 +/- 0.9 SD in the group 2.1 and 0.7, the gain being obtained during the first 2 years of treatment. Height of the totality of the treated patients was normalized in the 2 last groups. While the standard therapy allow only a partial catch up growth, the use of initial high doses of growth hormone, whatever the modality used, lead to a normalization of the height of the whole population. The data lead to preconise the use of high doses in the first years of growth hormone therapy.
Chaussain
J L
JL
Service d'Endocrinologie Pédiatrique, Hôpital Saint-Vincent de Paul, Paris.
D001827:Body Height; D002648:Child; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000628:therapy*; D013006:Growth Hormone / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D008297:Male
D013006:Growth Hormone