Non-steroidal anti-inflammatory drugs and chemoprevention of cancer.
Aspirin and other NSAIDs are showing promise in the chemoprevention of colorectal cancer. Ongoing trials will eventually provide still lacking information about the optimum dose and treatment duration. NSAIDs may also help to lower the risk of cancer in other organs such as the oesophagus, and possibly breast, stomach, and lung. The chemoprevention by NSAIDs should be seen not as the sole method of prevention, but as an additional tool which will be accompanied by other approaches such as stopping smoking, limiting alcohol consumption, and eating more fruits and vegetables. The chemoprevention by NSAIDs needs also to be balanced against the risks of toxicity (particularly in the stomach) and the other beneficial effects such as prevention of cardiovascular morbidity and mortality. Some of the NSAID induced gastric ulceration and bleeding will most likely be avoided by adopting the use of cyclooxygenase-2 (COX-2) selective NSAIDs, which will selectively inhibit COX-2 while sparing COX-1.
Vainio
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H
Unit of Chemoprevention, International Agency for Research on Cancer, Lyon, France. Vainio@iarc.fr
Morgan
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G
D000328:Adult; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000517:prevention & control; D006224:Cricetinae; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000517:prevention & control; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D010190:Pancreatic Neoplasms / Q000517:prevention & control; D011446:Prospective Studies; D011448:Prostaglandin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D011453:Prostaglandins / Q000502:physiology; D016032:Randomized Controlled Trials as Topic; D012878:Skin Neoplasms / Q000517:prevention & control; D013274:Stomach Neoplasms / Q000517:prevention & control; D013997:Time Factors; D019207:beta Carotene / Q000008:administration & dosage
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D019207:beta Carotene; D001241:Aspirin