title: Prevention of lung cancer. The new millennium.
abstract: Lung cancer is the leading cause of cancer-related death worldwide and in the United States surpassing breast, prostate, and colon cancer. Treatment of this disease over the past 2 decades has advanced incrementally as survival rates have improved only slightly. Alternate approaches to this deadly disease include an emphasis on prevention such as smoking cessation. Chemoprevention has introduced a new arena of treatment options for early intervention in lung carcinogenesis. The use of molecularly targeted therapeutic and biologic agents constitutes novel strategies for lung cancer prevention in the new millennium.
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Kim
authors.forename: W K
authors.initials: WK
authors.lastname: Hong
authors.forename: F R
authors.initials: FR
authors.lastname: Khuri
mesh_terms: D002338:Carotenoids / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000235:genetics / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000517:prevention & control; D008517:Phytotherapy; D011230:Precancerous Conditions / Q000517:prevention & control; D011322:Primary Prevention; D011519:Proto-Oncogenes / Q000235:genetics; D016032:Randomized Controlled Trials as Topic; D012176:Retinoids / Q000627:therapeutic use; D012307:Risk Factors; D012643:Selenium / Q000627:therapeutic use; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation; D013662:Tea / Q000627:therapeutic use; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D012176:Retinoids; D013662:Tea; D014810:Vitamin E; D002338:Carotenoids; D012643:Selenium