A Case of Advanced Breast Cancer Successfully Treated with Primary Endocrine Therapy.
We present a case of a premenopausal woman with advanced hormone-sensitive breast cancer who was successfully treated with primary endocrine therapy consisting of ovarian ablation followed by a combined endocrine regimen of the aromataseinhibitor fadrozole 2 mg daily and tamoxifen 20 mg daily. During the 5 months treatment period, PR evaluation of the loco-regional lesions was performed. The patient then underwent mastectomy with axillary lymph node dissection followed byfadrozole and tamoxifen therapy. Throughout the treatment course, no adverse events were encountered and the patient has been enjoying a favorable quality of life. As shown by this case, primary endocrine therapy is a promising treatment option for hormonesensitive breast cancer. However, this modality should be continued to be regarded as experimental.
Takatsuka
Y
Department of Surgery, Kansai Rosai Hospital, 3-1-69 Inabasou, Amagasaki 660-8511, Japan.
Kim
Y
Aritake
N
Hasegawa
S
Fukunaga
M
Imamoto
H
Maruyama
H