Chemopreventive effects of S-methylcysteine on rat hepatocarcinogenesis induced by concurrent administration of sodium nitrite and morpholine.
The aim of the present study was to examine the chemopreventive efficacy of S-methylcysteine (SMC) on rat hepatocarcinogenesis induced by concurrent administration of sodium nitrite (NaNO(2)) and morpholine (Mor) using a medium-term rat liver carcinogenesis bioassay (Ito test). Administration of SMC caused significant reduction in the areas of glutathione S-transferase placental form positive foci along with a significant decrease of hepatocyte 5-bromo-2'-deoxyuridine (BrdU) labeling indices. These results demonstrated potent chemopreventive effects of SMC against hepatocarcinogenesis due to concurrent administration of Mor and NaNO(2). SMC could thus be an effective chemopreventive agent for decreasing the risk of carcinogenicity from environmental precursors of N-nitroso compounds.
Wei
M
M
Department of Pathology, Osaka City University Medical School, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan.
Wanibuchi
H
H
Yamamoto
S
S
Iwai
S
S
Morimura
K
K
Nomura
T
T
Takayama
R
R
Fukushima
S
S
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D001973:Bromodeoxyuridine / Q000378:metabolism; D002273:Carcinogens / Q000493:pharmacokinetics / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D003545:Cysteine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004347:Drug Interactions; D005520:Food Preservatives / Q000493:pharmacokinetics / Q000633:toxicity*; D005753:Gastric Mucosa / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D008297:Male; D009025:Morpholines / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000633:toxicity*; D009602:Nitrosamines / Q000378:metabolism; D011230:Precancerous Conditions / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control; D051381:Rats; D011916:Rats, Inbred F344; D012977:Sodium Nitrite / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics / Q000633:toxicity*
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D005520:Food Preservatives; D009025:Morpholines; D009602:Nitrosamines; C002741:N-nitrosomorpholine; C037574:morpholine; C008425:S-methylcysteine; D005982:Glutathione Transferase; D001973:Bromodeoxyuridine; D003545:Cysteine; D012977:Sodium Nitrite