Functionalization of peptides and proteins by aldehyde or keto groups.
The functionalization of peptides and proteins by aldehyde or keto groups has become the subject of intensive research since the discovery of the inhibition properties of peptide aldehydes and the advent of protein engineering. The first part of this review focuses upon the tremendous efforts devoted to the solid-phase synthesis of peptide aldehydes as protease inhibitors. The second part describes the utility of the aldehyde or keto functionalities for the site-specific modification of peptides or proteins.
Melnyk
O
O
UMR 8525 Institut de Biologie et Institut Pasteur de Lille, Université de Lille 2, 1 rue du Pr Calmette, 59021 Lille, France. Oleg.melnyk@pasteur-lille.fr
Fehrentz
J A
JA
Martinez
J
J
Gras-Masse
H
H
D000447:Aldehydes / Q000737:chemistry; D005563:Formic Acid Esters; D007659:Ketones / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis*; D011506:Proteins / Q000138:chemical synthesis*; D012116:Resins, Plant
D000447:Aldehydes; D005563:Formic Acid Esters; D007659:Ketones; D010455:Peptides; D011506:Proteins; D012116:Resins, Plant; C000345:t-butyloxycarbonyl group