title: Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come.
abstract: In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse (). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a model organism is by no means over; indeed it is still rising to its peak: The mouse as a model mammalian organism still has much to offer. This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.
authors.affiliation: Hypnion Inc, Five Biotech, 381 Plantation Street, Worcester, Massachusetts 01605, USA. kjm@hypnion.aol.com
authors.forename: K J
authors.initials: KJ
authors.lastname: Moore
authors.forename: D L
authors.initials: DL
authors.lastname: Nagle
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D051379:Mice; D023421:Models, Animal; D019655:Quantitative Trait, Heritable