title: Wound complications in patients with carcinoma of the vulva. Comparison between radical and modified vulvectomies.
abstract: OBJECTIVE
  To evaluate complications after different vulvectomies performed because of vulvar cancer.
  
  
  METHODS
  Retrospective analysis of 149 patients who underwent vulvectomy.
  
  
  RESULTS
  Wound infections was found in 58%. Overweight, central or bilateral location of the tumor, and non-radical surgery were significant predictors of wound infections. Patients with a wound infection had more often wound breakdown (P<0.001), prolonged healing time (P<0.000), and lymphedema (P<0.001) than patients without infection. Antimicrobial prophylaxis did not prevent wound infection. Wound infections were found in 75% after radical en bloc vulvectomy (RV) and in 47% after modified vulvectomies (MV) (P<0.001). Also wound breakdown (47 versus 20%) (P<0.001) and lymphedema (48 versus 12%) (P<0.0001) were more common in RV group than in MV group. Lymphocysts were found in 7%, and showed no association with wound infection or type of operation. The mean hospital stay was 26 days in patients with wound infection and 12 days in patients without infection, 31 days in RV group and 12 days in MV group, respectively.
  
  
  CONCLUSIONS
  Wound infections are major determinants for both acute and late complications. Postoperative complications reduce with increasing use of modified vulvectomies.
authors.affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. arto.leminen@huch.fi
authors.forename: A
authors.initials: A
authors.lastname: Leminen
authors.forename: M
authors.initials: M
authors.lastname: Forss
authors.forename: J
authors.initials: J
authors.lastname: Paavonen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019072:Antibiotic Prophylaxis; D005260:Female; D006801:Humans; D007902:Length of Stay; D008875:Middle Aged; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology* / Q000517:prevention & control; D014844:Vulva / Q000601:surgery*; D014846:Vulvar Neoplasms / Q000601:surgery*