Disturbance of cardiovascular circadian rhythms by pertussis vaccine in freely-moving rats.
Vaccination of young children with diphtheria, tetanus, poliomyelitis and pertussis (DTPoP) vaccine is effective in preventing outbreaks of whooping cough but adverse events sometimes occur. This pilot study shows that in freely-moving rats, multiple treatment with DTPoP (at day 0 and day 5, 6 ml/kg i.v.) increased heart rate (HR) for 5 days after the first treatment and decreased diastolic blood pressure (DBP) for at least 26 days after the first treatment and inhibited the circadian rhythm of HR and DBP for at least 10 days. DTPo vaccine, containing no pertussis vaccine, was free of such effects. Thus, in rats, the pertussis component of DTPoP acts on the cardiovascular system and disturbs its circadian rhythm. The contribution of these findings to clinical adverse effects is as yet unknown and needs further research.
Vleeming
W
W
National Institute of Public Health and the Environment, Laboratory of Health Effects Research, Bilthoven, The Netherlands.
van de Kuil
A
A
te Biesebeek
J D
JD
van der Laan
J W
JW
de Wildt
D J
DJ
van Amsterdam
J G
JG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000633:toxicity*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000633:toxicity*; D004334:Drug Administration Schedule; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000633:toxicity*; D010865:Pilot Projects; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013686:Telemetry; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000633:toxicity*; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000633:toxicity*
C051021:DTPP vaccine; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D010567:Pertussis Vaccine; D011054:Poliovirus Vaccine, Inactivated; D013745:Tetanus Toxoid; D017778:Vaccines, Combined