[Comparative evaluation of the action of altiazem PP-180 taken at different time of the day by patients with stage-II hypertension].
OBJECTIVE
To study time-dependent effects of altiazem PP-180 and its influence on circadian pattern of hemodynamics in patients with essential hypertension stage II in its administration in 8.00, 14.00 and 22.00.


METHODS
30 patients with essential hypertension stage II (mean age 63.3 years) were divided into 3 groups 10 patients each by time of altiazem intake: 8.00, 14.00 or 22.00. Altiazem was given in a single daily dose 180 mg for 10 days. Before and after the treatment, a circadian profile of arterial pressure according to Korotkov was determined, 24-h monitoring of arterial pressure was made (AP-monitor Astrakard, Russia) and echo-CG measurements of hemodynamics were made (Toshiba, Japan). Tetrapolar chest rheography was also performed.


RESULTS
More potent hypotensive effect of altiazem was observed in its administration in 8.00 and 22.00, less potent in 14.00. Negative chronotropic and positive inotropic effects occurred in its morning intake. These effects are less prominent in the evening and minimal if taken in 14.00. Normalization of circadian hemodynamic rhythms was registered in altiazem intake only in the morning.


CONCLUSIONS
Altiazem PP-180 produces time-related hemodynamic effects.
Zaslavskaia
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D002940:Circadian Rhythm; D004110:Diltiazem / Q000008:administration & dosage*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004110:Diltiazem