title: Cocaine-induced reflex sympathetic dystrophy.
abstract: Reflex sympathetic dystrophy (RSD) usually follows traumatic injuries or neurologic disorders. The authors report a rare case of RSD that followed intraarterial administration of cocaine in a patient with a history of intravenous drug abuse. The cocaine was self-administered inadvertently into the femoral artery rather than the femoral vein. Despite the intense pain, swelling, and dermatologic changes that followed, the diagnosis of RSD was not considered until scintigraphic studies suggested it. A combination of normal radiographs, a normal leukocyte study, and an abnormal bone scan in the region of tenderness and swelling excluded other possibilities and suggested RSD. In our patient, RSD was likely caused by an ischemic autonomic injury from the vasoconstrictor action of cocaine. Clinical follow-up and relief using phentolamine, an alpha-adrenergic blocker and vasodilator, made the diagnosis of RSD most likely.
authors.affiliation: Department of Radiology, University of Missouri Health Sciences Center, Columbia, USA.
authors.forename: D
authors.initials: D
authors.lastname: Gay
authors.forename: A
authors.initials: A
authors.lastname: Singh
mesh_terms: D019970:Cocaine-Related Disorders / Q000150:complications*; D005260:Female; D005263:Femoral Artery; D005528:Foot / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012019:Reflex Sympathetic Dystrophy / Q000139:chemically induced* / Q000000981:diagnostic imaging; D015819:Substance Abuse, Intravenous / Q000150:complications*; D013669:Technetium Tc 99m Medronate; D014661:Vasoconstriction
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate