title: Cholinergic modulation of the sleep state-dependent P13 midlatency auditory evoked potential in the rat.
abstract: Injections into the pedunculopontine nucleus (PPN) of the cholinergic receptor agonist, carbachol (CAR), were found to reduce the amplitude of the vertex-recorded, sleep state-dependent P13 midlatency evoked potential in a dose- and time-dependent manner. This effect was blocked or reduced by pretreatment with the muscarinic receptor antagonist, scopolamine, injected into the PPN.
authors.affiliation: Department of Physiology, Univ. de Los Andes, Merida, Venezuela.
authors.forename: L
authors.initials: L
authors.lastname: Teneud
authors.forename: H
authors.initials: H
authors.lastname: Miyazato
authors.forename: R D
authors.initials: RD
authors.lastname: Skinner
authors.forename: E
authors.initials: E
authors.lastname: Garcia-Rill
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008636:Mesencephalon / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009434:Neural Pathways / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011149:Pons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism; D012154:Reticular Formation / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D012601:Scopolamine / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects* / Q000502:physiology
chemical_list: D011976:Receptors, Muscarinic; D002217:Carbachol; D012601:Scopolamine; D000109:Acetylcholine