title: Tropical theileriosis in Tunisia: epidemiology and control.
abstract: In Tunisia, tropical theileriosis (Theileria annulata infection of cattle) is one of the major diseases affecting cattle in the summer. Each year about 2,500 clinical cases are recorded in the country, mainly in pure-bred animals. An attempt was made in the North of Tunisia to estimate the direct cost related to clinical cases of TT. In the endemic regions, three states of endemicity were described according to cattle age categories at highest disease risk: (i) endemic stability, (ii) low endemic instability, (iii) high endemic instability. The characterisation of these endemic situations, which are conditioned by the levels of the vector tick population and the quantitative aspects of the infection in ticks, are highly relevant for the development of a live attenuated cell line vaccine against TT targeting the cattle population at disease risk in Tunisia. A research programme was set up to develop the attenuation of four local parasite stocks. Two cell lines infected with two distinct T. annulata stocks were tested in the field on pure-bred animals of different age groups from regions with high disease incidence. The vaccination with each of the two cell lines showed a high efficacy. However significant differences in vaccine reactions rates were observed between the two attenuated cell lines emphasising the importance of achieving an optimal balance between protection and vaccine tolerance particularly in pure-bred lactating cows.
authors.affiliation: Service de Parasitologie, Ecole Nationale de Médecine Vétérinaire, Tunisia.
authors.forename: M A
authors.initials: MA
authors.lastname: Darghouth
authors.forename: A
authors.initials: A
authors.lastname: Bouattour
authors.forename: M
authors.initials: M
authors.lastname: Kilan
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D008297:Male; D015995:Prevalence; D013801:Theileriasis / Q000453:epidemiology* / Q000517:prevention & control; D013987:Ticks; D014416:Tunisia / Q000453:epidemiology