title: A novel beta-glucuronidase inhibiting triterpenoid from Paeonia emodi.
abstract: A novel beta-glucuronidase inhibiting triterpene (1) has been isolated from the chloroform fraction of Paeonia emodi beta-glucuronidase inhibit established ase chloroform fraction of Pa 11,beta,5alpha,23,24-pentahydroxy-30-norolean-12,20(29)-d ien-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spectroscopy, one and two-dimensional NMR techniques. Oleanolic acid, betulinic acid, ethyl gallate, methyl grevillate and 1,5-dihydroxy-3-methylanthraquinone are also reported for the first time from Paeonia emodi.
authors.affiliation: International Centre for Chemical Sciences HEJ Research Institute of Chemisty, University of Karachi, Pakistan.
authors.forename: H R
authors.initials: HR
authors.lastname: Nawaz
authors.forename: A
authors.initials: A
authors.lastname: Malik
authors.forename: P M
authors.initials: PM
authors.lastname: Khan
authors.forename: S
authors.initials: S
authors.lastname: Shujaat
authors.forename: A
authors.initials: A
authors.lastname: Rahman
mesh_terms: D000107:Acetylation; D001208:Asia; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D005966:Glucuronidase / Q000037:antagonists & inhibitors*; D008745:Methylation; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C421563:1,3,5,23,24-pentahydroxy-30-norolean-12,20(29)-dien-28-oic acid; D004791:Enzyme Inhibitors; D014315:Triterpenes; D005966:Glucuronidase