[Influence of tobacco smoking on the sum epoxycholesterols levels in serum of pregnant women with diabetes].
OBJECTIVE
The aim of our study was to estimate concentration of epoxycholesterols sum (5 alpha,6 alpha and 5 beta,6 beta) in groups of pregnant women with diabetes mellitus and/or PIH, who had been exposed to tobacco smoke.


METHODS
Examined patients were divided into the following groups: 35 patients with gestational diabetes, 25 patients with diabetes mellitus, 17 patients with gestational diabetes coexisting with PIH. The control group consist with 24 health pregnant women. Epoxycholesterols were estimated by thin layer chromatography.


RESULTS
We stated exact relationship between sum of epoxycholesterols and degree of exposition to tobacco smoke in group of patients with diabetes mellitus and gestational diabetes mellitus. In group of pregnant women with gestational diabetes mellitus coexisting with PIH we didn't find statistically important differences in concentrations of examined value, although it was on permanently high level.


CONCLUSIONS
The authors concluded, that free oxygen radicals enclosed in tobacco smoke catalyzed processes of cholesterol oxygenation in pregnant women bodies. Besides we stated, that increased levels of epoxycholesterols cold be one of the factors responsible for PIH. Our results indicate to need of further studies possible part of oxycholesterols in prenatal pathology.
Bodzek
P
P
Katedry i Oddziału Klinicznego Połoznictwa i Ginekologii w Bytomiu Slaskiej Akademii Medycznej w Katowicach.
Olejek
A
A
D000328:Adult; D002789:Cholesterol Oxidase / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood* / Q000201:enzymology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000201:enzymology*; D015227:Lipid Peroxidation / Q000502:physiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011254:Pregnancy in Diabetics; D012907:Smoking / Q000009:adverse effects*
D002789:Cholesterol Oxidase