[tag7 Gene and gene therapy of cancer].
Modern gene therapeutic approaches towards the treatment of malignant neoplasms are discussed. Specifically, results of the first experiments on the development of vaccines on the basis of tumor cells modified with various cytokines and activation molecules are described. We compare effectiveness of different cytokines used for modification of tumor cells are made and consider possible mechanisms of vaccine action. The reasons for impossibility of the development of effective endogenous antitumor immunity are examined. The results of comparative analysis of the Tag7 protein antitumor activity are presented. This evidence clearly shows that Tag7 is a promising agent for anticancer therapy.
Kiselev
S L
SL
Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia. slk@mx.ibg.relarn.ru
Larin
S S
SS
Gnuchev
N V
NV
Georgiev
G P
GP
D000818:Animals; D019496:Cancer Vaccines / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D015316:Genetic Therapy; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D023041:Xenograft Model Antitumor Assays
D019496:Cancer Vaccines; D016207:Cytokines; D007376:Interleukin-2; C491878:PGLYRP1 protein, human; D016178:Granulocyte-Macrophage Colony-Stimulating Factor