title: New norditerpenoid alkaloids from Aconitum falconeri.
abstract: The roots of Aconitum falconeri have yielded two new norditerpenoid alkaloids, faleoconitine (1) and 3'-methoxyacoforestinine (2) along with the known compounds, karakoline, 3-hydroxy-2-methyl-4H-pyran-4-one, and 3,4-dimethoxymethylbenzoate, which have been isolated for the first time from this plant. The previously reported pseudaconitine (3) was also isolated. Compounds 1 and 3 were found to be moderate inhibitors of the enzyme acetylcholinesterase.
authors.affiliation: International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan. hejric@digicom.net.pk
authors.lastname: Atta-Ur-Rahman
authors.forename: N
authors.initials: N
authors.lastname: Fatima
authors.forename: F
authors.initials: F
authors.lastname: Akhtar
authors.forename: M I
authors.initials: MI
authors.lastname: Choudhary
authors.forename: A
authors.initials: A
authors.lastname: Khalid
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D019684:Magnoliopsida / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry
chemical_list: C416563:3'-methoxyacoforestinine; D002800:Cholinesterase Inhibitors; D004224:Diterpenes; C416562:faleoconitine; C416564:pseudaconitine