title: Efficacy and safety of prone positioning for patients with acute respiratory distress syndrome.
abstract: This article presents an overview of a literature review on how prone positioning can alleviate pathophysiological changes in ARDS and improve ventilation and perfusion. Improvement of gas exchange, efficiency of oxygenation and lung function are emphasized. Literature on the pathophysiology of ARDS, and the physiological effects of prone positioning on haemodynamics and lung function is examined. There are both advantages and disadvantages in turning a patient from the supine to the prone position. There are also contraindications in rotating between the supine and prone positions. Nevertheless, by rotating patients with ARDS, it is possible to achieve a significant improvement in A-aDO2, decrease shunting, and therefore improve oxygenation without use of expensive, invasive and experimental procedures. Placing patients with ARDS in the prone position can reduce inspiratory oxygen concentrations and peak inspiratory pressures, which minimizes the chance for barotrauma and the iatrogenic effects of hyperventilation oxygen toxicity.
authors.affiliation: University of Kansas Medical Center, School of Nursing, Kansas City 66160-7504, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Breiburg
authors.forename: L
authors.initials: L
authors.lastname: Aitken
authors.forename: L
authors.initials: L
authors.lastname: Reaby
authors.forename: R L
authors.initials: RL
authors.lastname: Clancy
authors.forename: J D
authors.initials: JD
authors.lastname: Pierce
mesh_terms: D001784:Blood Gas Analysis; D003422:Critical Care / Q000379:methods* / Q000592:standards; D006439:Hemodynamics; D006801:Humans; D010101:Oxygen Consumption; D016684:Prone Position; D011659:Pulmonary Gas Exchange; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000378:metabolism / Q000451:nursing* / Q000503:physiopathology*; D012399:Rotation; D012449:Safety; D016683:Supine Position; D013997:Time Factors; D016896:Treatment Outcome