Cassine, an antimicrobial alkaloid from Senna racemosa.
The leaves of Senna racemosa yielded the piperidine alkaloid cassine and an inositol methyl ether. Antimicrobial screening of the compounds revealed antibacterial activity of cassine with minimum inhibitory concentrations of 2.5 mg/ml for Staphylococcus aureus and Bacillus subtilis and 5.0 mg/ml for Candida albicans.
Sansores-Peraza
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P
Facultad de Química, Universidad Autónoma de Yucatán, 41 No. 421 Col. Industrial, 97150 Mérida Yucatán, Mexico.
Rosado-Vallado
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M
Brito-Loeza
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W
Mena-Rejón
G J
GJ
Quijano
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L
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007659:Ketones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010880:Piperidines / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D007659:Ketones; D010880:Piperidines; D010936:Plant Extracts; C426663:cassine