Transmission of human T-cell leukaemia virus type I into adult mice.
Human T-cell leukaemia virus type I (HTLV-I)-transformed rabbit T-cells, F647a, were intraperitoneally injected into eight 10-week-old C3H/He and C3H/HeJ mice (1 x 10(7) F647a cells/mouse), respectively. Antibody titres against HTLV-I increased to a peak at 1-3 months after injection in both C3H/He and C3H/HeJ mice. At 12 months after injection, antibody titres of two of the eight C3H/HeJ mice became undetectable, whereas those of all the C3H/He mice still ranged from 1:10 to 1:40. Sera from both seropositive C3H/He and C3H/HeJ mice reacted with HTLV-I core proteins, but not with the env protein. HTLV-I proviral sequences were detected in two of eight C3H/He mice and three of the eight C3H/HeJ mice. These results suggest that HTLV-I is able to infect an adult mouse.
Ohsugi
T
T
SPF Animal Research Facility, Atopy (Allergy) Research Centre, Juntendo University School of Medicine, Tokyo, Japan.
D000375:Aging; D000818:Animals; D015153:Blotting, Western / Q000662:veterinary; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis; D015481:HTLV-I Antibodies / Q000096:biosynthesis; D015490:HTLV-I Infections / Q000635:transmission / Q000662:veterinary*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011533:Proviruses / Q000235:genetics / Q000302:isolation & purification; D011817:Rabbits; D012376:Rodent Diseases / Q000635:transmission* / Q000821:virology; D013047:Specific Pathogen-Free Organisms
D004279:DNA, Viral; D015481:HTLV-I Antibodies