A process to produce effervescent tablets: fluidized bed dryer melt granulation.
The purpose of the present study was to apply melt granulation in a fluidized bed dryer (fluidized bed dryer melt granulation) to manufacture one-step effervescent granules composed of anhydrous citric acid and sodium bicarbonate to make tablets. This study permitted us to establish that such process parameters as concentrations of polyethylene glycol (PEG) 6000, residence times in the fluidized bed dryer, fineness of PEG6000, fineness of initial mixture effervescent systems, and efficiency of two lubricants markedly affect some granule and tablet characteristics. It is a dry process that is simple, rapid, effective, economical, reproducible, and particularly adapted to produce effervescent granules that are easily compressed into effervescent tablets.
Yanze
F M
FM
Laboratoire de pharmacie galénique, pharmacotechnie et de Biopharmacie, Université Montpellier I, UFR de Sciences Pharmaceutiques, France. fmyanze@libertysurf.fr
Duru
C
C
Jacob
M
M
D000925:Anticoagulants; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019343:Citric Acid; D010316:Particle Size; D011092:Polyethylene Glycols; D017693:Sodium Bicarbonate; D013607:Tablets; D013678:Technology, Pharmaceutical
D000925:Anticoagulants; D013607:Tablets; D019343:Citric Acid; D011092:Polyethylene Glycols; D017693:Sodium Bicarbonate