Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study.
Archived sera (collected in 1946) from acute rheumatic fever (ARF) and untreated scarlet fever and/or pharyngitis patients were reacted with streptococcal M protein, cardiac myosin, and cardiac tropomyosin. Except for very low levels to tropomyosin, antibodies to other antigens were not elevated in the sera of ARF patients relative to those of non-ARF patients, even though there was roughly equivalent exposure to group A streptococci. This suggests that antibodies to these molecules may not play a central role in the induction of ARF.
Jones
K F
KF
SIGA Research Laboratories, Corvallis, Oregon 97333, USA. kjones@sgph.com
Whitehead
S S
SS
Cunningham
M W
MW
Fischetti
V A
VA
D000208:Acute Disease; D000595:Amino Acid Sequence; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009218:Myosins / Q000276:immunology*; D012189:Retrospective Studies; D012213:Rheumatic Fever / Q000209:etiology / Q000276:immunology*; D012541:Scarlet Fever / Q000209:etiology / Q000276:immunology*; D014335:Tropomyosin / Q000276:immunology*
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D014335:Tropomyosin; C014689:streptococcal M protein; D009218:Myosins