title: [Neurosurgical therapy for parkinson's disease].
abstract: Stereotactic surgery and neuronal transplantation are considered to be effective surgical therapies for advanced Parkinson's disease with wearing off phenomenon. As a stereotactic surgery, posteroventral pallidotomy and chronic pallidal or subthalamic stimulation with inhibitory parameters were performed. Flattening of the motor fluctuations were obtained with improving general motor symptoms especially at "off" time. Therapeutic l-dopa dose could not reduced following pallidotomy and pallidal stimulation, whereas subthalamic stimulation saved 30-50% of l-dopa dose. By the constant supply of dopamine, neuronal transplantation was effective on wearing off. Chromaffin cells of adrenal medulla and pretransected peripheral nerve were cografted into the bilateral caudate nuclei. After the transplantation significant reduction of % time off and l-dopa dose was observed.
authors.affiliation: Department of Neurological Surgery, Okayama University Medical School.
authors.forename: S
authors.initials: S
authors.lastname: Tomita
authors.forename: I
authors.initials: I
authors.lastname: Date
authors.forename: T
authors.initials: T
authors.lastname: Ohmoto
mesh_terms: D000313:Adrenal Medulla / Q000166:cytology; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects; D017690:Cell Transplantation; D004599:Electric Stimulation Therapy; D005260:Female; D005917:Globus Pallidus / Q000601:surgery; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D010300:Parkinson Disease / Q000601:surgery*; D010525:Peripheral Nerves / Q000637:transplantation*; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000601:surgery
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa