Synthesis and use of DNA containing a 5'-bridging phosphorothioate as a suicide substrate for type I DNA topoisomerases.
Burgin
A B
AB
Enzymology Division, Ribozyme Pharmaceuticals, Boulder, CO, USA.
D001665:Binding Sites; D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D007700:Kinetics; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010710:Phosphates / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D013379:Substrate Specificity; D013936:Thymidine / Q000031:analogs & derivatives / Q000378:metabolism; D059004:Topoisomerase I Inhibitors; D014443:Tyrosine / Q000378:metabolism; D014616:Vaccinia virus / Q000201:enzymology
D009838:Oligodeoxyribonucleotides; D010710:Phosphates; D059004:Topoisomerase I Inhibitors; D014443:Tyrosine; D004247:DNA; D004264:DNA Topoisomerases, Type I; D013936:Thymidine