Disposition of olanzapine in Chinese schizophrenic patients.
The disposition of olanzapine was evaluated in 21 male chronic schizophrenic patients. A single 10 mg dose of olanzapine was administered and blood sampling performed over the following 120 hours. The mean (+/- SD) oral clearance and elimination half-life of olanzapine were 51.5+/-61.6 l/h and 30.9+/-4.3 hours, respectively. A wide interpatient variability was found. Compared to the population norms, no significant differences were observed between different populations and Chinese patients in olanzapine disposition.
Lane
H Y
HY
Department of Psychiatry, Tzu-Chi General Hospital and Tzu-Chi University, Hualien, Taiwan.
Liu
H C
HC
VanDenBerg
C M
CM
Su
M H
MH
Jann
M W
MW
Chang
W H
WH
D000328:Adult; D044466:Asian People; D001569:Benzodiazepines; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism*
D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine