Aging and resistance to Trichinella spiralis infection following xenobiotic exposure.
Aging is accompanied by well-documented physiological changes, including alterations in the immune system that can lead to reduced resistance to a variety of infectious agents. We tested the hypothesis that immunosenescence exacerbates the immunosuppressive effect of xenobiotics. If proven true, a given dose of an immunosuppressive xenobiotic would cause greater suppression of host resistance in an aged population.
Luebke
R W
RW
Immunotoxicology Branch, Experimental Toxicology Division, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. luebke.robert@epamail.epa.gov
Copeland
C B
CB
Andrews
D L
DL
D000375:Aging / Q000187:drug effects* / Q000276:immunology*; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007814:Larva / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology; D051381:Rats; D017160:Trichinella spiralis / Q000276:immunology* / Q000502:physiology; D014235:Trichinellosis / Q000276:immunology* / Q000469:parasitology; D015262:Xenobiotics / Q000494:pharmacology*
D000947:Antigens, Helminth; D007166:Immunosuppressive Agents; D000072317:Polychlorinated Dibenzodioxins; D015262:Xenobiotics