Diheteropeptin, a novel substance with TGF-beta-like activity, produced by a fungus, Diheterospora chlamydosporia. II. Physico-chemical properties and structure elucidation.
The structure of diheteropeptin (1), a TGF-beta-like active substance from Diheterospora chlamydosporia Q58044, was determined to be a new cyclotetrapeptide, cyclo[2aminoisobutyryl-(S)-phenylalanyl-(R)-prolyl-(2S,8R,9R)-2-am ino-8,9-dihydroxydecanoyl-] by NMR, mass spectrometric and chemical studies.
Masuoka
Y
Y
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
Shin-Ya
K
K
Furihata
K
K
Matsumoto
H
H
Takebayashi
Y
Y
Nagai
K
K
Suzuki
K
K
Hayakawa
Y
Y
Seto
H
H
D002942:Circular Dichroism; D003652:Decanoic Acids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006999:Hypocreales / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism; D016212:Transforming Growth Factor beta / Q000494:pharmacology
D003652:Decanoic Acids; D016212:Transforming Growth Factor beta; C111146:diheteropeptin