title: Resuscitation of severe thermal injury with hypertonic saline dextran: effects on peripheral and visceral edema in sheep.
abstract: BACKGROUND
  Edema of tissue not directly injured by heat is a common complication after resuscitation of burn shock. Hypertonic 7.5% NaCl 6% dextran (HSD) infusion reduces early fluid requirements in burn shock, but the effects of HSD on peripheral and visceral tissue edema are not well-defined.
  
  
  METHODS
  We measured the microcirculatory absorptive pressures of burned and nonburned skin and tissue water content of skin and other tissues in anesthetized sheep after 70% to 85% total body surface area scald and resuscitation. Fluid infusion was initiated 30 minutes after injury using 10 mL/kg HSD (n = 11) or lactated Ringer's (LR) (n = 12), with infusion rates titrated to restore and maintain preburn oxygen delivery (DO2). Thereafter, both groups received LR infusions as needed to maintain DO2 until the study's end at 8 hours. Colloid osmotic pressure was measured in plasma, and combined interstitial colloid osmotic and hydrostatic pressures were measured in skin.
  
  
  RESULTS
  Both treatments successfully restored DO2, but fluid requirements were less with the HSD group than with the LR group (43+/-19 mL/kg vs. 194+/-38 mL/kg, respectively, p < 0.05). The peripheral and visceral tissue water contents at 8 hours postinjury until the end of the study in both burn groups were significantly higher than in nonburn controls. However, HSD-treated sheep had significantly less water content in the colon (less 28%), liver (less 9%), pancreas (less 55%), skeletal muscle (less 21%), and nonburned skin (less 12%) compared with LR-treated sheep (p < 0.05 for each). HSD-treated sheep maintained significantly higher (3 to 5 mm Hg) plasma colloid osmotic pressure than LR-treated sheep.
  
  
  CONCLUSIONS
  There were no observed differences in edema in burn skin between the two treatment groups. The early volume-sparing effect of HSD and reduction in tissue edema are likely attributed to an increased extracellular osmolarity and a better maintenance of the plasma oncotic pressure.
authors.affiliation: Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Institute, Galveston, Texas 77555-0801, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Kinsky
authors.forename: S M
authors.initials: SM
authors.lastname: Milner
authors.forename: B
authors.initials: B
authors.lastname: Button
authors.forename: M A
authors.initials: MA
authors.lastname: Dubick
authors.forename: G C
authors.initials: GC
authors.lastname: Kramer
mesh_terms: D000818:Animals; D002056:Burns / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D003911:Dextrans / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004487:Edema / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006439:Hemodynamics; D006874:Hydrostatic Pressure; D007552:Isotonic Solutions / Q000627:therapeutic use; D009929:Organ Size; D009997:Osmotic Pressure; D010101:Oxygen Consumption; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011897:Random Allocation; D012151:Resuscitation / Q000379:methods*; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012756:Sheep
chemical_list: D003911:Dextrans; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D000077325:Ringer's Lactate; D012462:Saline Solution, Hypertonic