[Uremic coagulopathy. Role of thrombin].
The recent observation of increased thrombogenesis in chronic renal failure suggest a pathogenetic role of thrombin in hemorrhagic diathesis of chronic renal failure that may link two paradoxical aspects of this diathesis: hemorrhage and thrombosis. Not only: the accelerated atherosclerosis in uremic patient is also underlined. The possibility of thrombin therapeutic inhibition is then discussed.
Camici
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Dipartimento di Medicina Interna, Università degli Studi, Pisa.
Sagripanti
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D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D000991:Antithrombins / Q000378:metabolism; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology; D001778:Blood Coagulation Disorders / Q000097:blood / Q000209:etiology*; D001792:Blood Platelets / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D065427:Factor Xa Inhibitors; D005341:Fibrinolysin / Q000378:metabolism; D006474:Hemorrhagic Disorders / Q000097:blood / Q000209:etiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications; D008074:Lipoproteins / Q000502:physiology; D008954:Models, Biological; D011486:Protein C / Q000378:metabolism; D044463:Receptor, PAR-1; D018179:Receptors, Thrombin / Q000187:drug effects / Q000502:physiology; D012995:Solubility; D013917:Thrombin / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D019851:Thrombophilia / Q000097:blood / Q000209:etiology; D014511:Uremia / Q000097:blood / Q000150:complications*
D000925:Anticoagulants; D000991:Antithrombins; D065427:Factor Xa Inhibitors; D008074:Lipoproteins; D011486:Protein C; D044463:Receptor, PAR-1; D018179:Receptors, Thrombin; C051928:lipoprotein-associated coagulation inhibitor; D013917:Thrombin; D005341:Fibrinolysin