Activation of human CIC-2 Cl- channels: implications for cystic fibrosis.
1. The CIC-2 Cl- channels are present in the adult human lung epithelia and, therefore, are a potential target for therapy in cystic fibrosis. 2. Activators of CIC-2 Cl- channels that may have physiological relevance include activation by reduced external pH, protein kinase A and arachidonic acid. 3. Activators of CIC-2 Cl- channels that have therapeutic potential include amidation and omeprazole and, perhaps, effectors of arachidonic acid metabolism.
Cuppoletti
J
J
Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Ohio 45267-0576, USA. john.cuppoletti@uc.edu
Tewari
K P
KP
Sherry
A M
AM
Malinowska
D H
DH
D000595:Amino Acid Sequence; D000818:Animals; D001711:Biotransformation; D065101:Chloride Channel Agonists; D018118:Chloride Channels / Q000737:chemistry / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data
D065101:Chloride Channel Agonists; D018118:Chloride Channels