title: L-3-[123I]Iodo-alpha-methyltyrosine scintigraphy in carcinoid tumors: correlation with biochemical activity and comparison with [111In-DTPA-D-Phe1]-octreotide imaging.
abstract: Carcinoid tumors can produce serotonin (5-hydroxytryptamine) and catecholamines from the precursors tryptophan and tyrosine. Our aim was to evaluate the tyrosine analog L-3-[123I]iodo-alpha-methyltyrosine (IMT) in the detection and the determination of biochemical activity of these tumors in comparison with 111In-labeled [diethylenetriaminepentaacetic acid (DTPA)-D-Phe1]-octreotide (111In-octreotide) scintigraphy.
  
  
  METHODS
  SPECT and planar whole-body imaging were performed 15 min after administration of 300 MBq IMT in 22 patients with metastatic carcinoid tumors. The number of lesions detected was compared with the number detected by 111In-octreotide scintigraphy. The size and intensity of uptake of all lesions were graded using a simple scoring system, yielding a total body uptake score for both tracers. These scores were compared (nonparametric correlation) with biochemical markers of serotonin and catecholamine metabolism.
  
  
  RESULTS
  IMT SPECT detected only 63 of 145 lesions detected by 111In-octreotide imaging (43%). IMT SPECT performance was best in the liver (60% detection rate). Both IMT uptake and 111In-octreotide uptake scores correlated with markers of serotonin metabolism (respective values for urinary 5-hydroxyindoleacetic acid: r = 0.67 and 0.48, P < 0.001 and 0.05; for urinary serotonin: r = 0.56 and 0.40, P = 0.002 and 0.05; and for platelet serotonin: r = 0.57 and 0.45, P < 0.01 and 0.05). No correlation with adrenaline or noradrenaline metabolites was found. However, IMT uptake, but not 111In-octreotide uptake, correlated with dopamine metabolite excretion (homovanillic acid: r = 0.60, P < 0.05; and dopamine relative sum: r = 0.61, P < 0.05). IMT uptake was higher in patients with increased dopamine metabolite excretion (P = 0.05).
  
  
  CONCLUSIONS
  IMT uptake can be demonstrated in carcinoid lesions, but the method detected only 43% of carcinoid lesions that were positive on 111In-octreotide scintigraphy. Uptake of both tracers is related to the serotonin secretory activity. However, IMT uptake, but not 111In-octreotide uptake, was related to tumor dopamine metabolism. These findings may be of interest in the metabolic targeting of carcinoids.
authors.affiliation: Department of Nuclear Medicine, University Hospital Groningen, The Netherlands.
authors.forename: P L
authors.initials: PL
authors.lastname: Jager
authors.forename: W G
authors.initials: WG
authors.lastname: Meijer
authors.forename: I P
authors.initials: IP
authors.lastname: Kema
authors.forename: P H
authors.initials: PH
authors.lastname: Willemse
authors.forename: D A
authors.initials: DA
authors.lastname: Piers
authors.forename: E G
authors.initials: EG
authors.lastname: de Vries
mesh_terms: D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008297:Male; D008781:Methyltyrosines; D008875:Middle Aged; D015282:Octreotide / Q000031:analogs & derivatives*; D011877:Radionuclide Imaging; D012701:Serotonin / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D008781:Methyltyrosines; C094279:indium-111-octreotide; D012701:Serotonin; C030855:3-iodo-alpha-methyltyrosine; D015282:Octreotide