Cholinergic modulation of the sleep state-dependent P13 midlatency auditory evoked potential in the rat.
Injections into the pedunculopontine nucleus (PPN) of the cholinergic receptor agonist, carbachol (CAR), were found to reduce the amplitude of the vertex-recorded, sleep state-dependent P13 midlatency evoked potential in a dose- and time-dependent manner. This effect was blocked or reduced by pretreatment with the muscarinic receptor antagonist, scopolamine, injected into the PPN.
Teneud
L
L
Department of Physiology, Univ. de Los Andes, Merida, Venezuela.
Miyazato
H
H
Skinner
R D
RD
Garcia-Rill
E
E
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008636:Mesencephalon / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009434:Neural Pathways / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D011149:Pons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism; D012154:Reticular Formation / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D012601:Scopolamine / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects* / Q000502:physiology
D011976:Receptors, Muscarinic; D002217:Carbachol; D012601:Scopolamine; D000109:Acetylcholine