16Beta-hydroxy-5alpha-cholestane-3,6-dione, a novel cytotoxic oxysterol from the red alga Jania rubens.
A new cytotoxic oxysterol, 16beta-hydroxy-5alpha-cholestane-3,6-dione was isolated from the red alga Jania rubens. Its structure was established by spectroscopic method. The ID50 value was 0.5 microg/mL.
Ktari
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Laboratoire de Chimie des Substances Naturelles, associé au CNRS, Muséum National d'Histoire Naturelle, Paris, France.
Blond
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Guyot
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D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D002778:Cholestanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D000461:Rhodophyta / Q000737:chemistry*; D014407:Tumor Cells, Cultured
C420965:16-hydroxycholestane-3,6-dione; D000972:Antineoplastic Agents, Phytogenic; D002778:Cholestanones