[Radiation-induced superficial fibrosis and TGF-alpha 1].
Radiation-induced fibrosis is a late sequela of both therapeutic and accidental irradiations, which has been described in various tissues, including the lung, liver, kidney and skin. This review presents different aspects of superficial radiation-induced fibrosis, such as clinical observations, histological changes, cellular and molecular regulations, and medical management. Recent evidence on the critical role played by TGF-beta 1 in the initiation, development and persistence of fibrosis are discussed, as well as the possibility that this cytokine may constitute a specific target for antifibrotic agents.
Martin
M
M
Laboratoire de radiobiologie et d'étude du génome, DRR, DSV, CEA Saclay, Gif-sur-Yvette, France.
Delanian
S
S
Sivan
V
V
Vozenin-Brotons
M C
MC
Reisdorf
P
P
Lawrence
D
D
Lefaix
J L
JL
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000473:pathology / Q000528:radiation effects; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D011832:Radiation Injuries / Q000473:pathology* / Q000517:prevention & control; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000502:physiology*; D053773:Transforming Growth Factor beta1
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1