title: The effects of salicylate on bacteria.
abstract: Salicylate and related compounds, such as aspirin, have a variety of effects in eucaryotic systems and are well known for their medicinal properties. Salicylate also has numerous effects on bacteria, yet only a handful of individuals within the scientific community appreciate these findings. From a bacterial viewpoint, growth in the presence of salicylate can be both beneficial and detrimental. On one hand, growth of certain bacteria in the presence of salicylate can induce an intrinsic multiple antibiotic resistance phenotype. On the other hand, growth in the presence of salicylate can reduce the resistance to some antibiotics and affect virulence factor production in some bacteria. This review provides an overview of the effects salicylate has on various bacterial species.
authors.affiliation: Microbiology and Biochemistry Groups, School of Biomedical Sciences, Curtin University of Technology, Perth 6845, WA, Australia.
authors.forename: C T
authors.initials: CT
authors.lastname: Price
authors.forename: I R
authors.initials: IR
authors.lastname: Lee
authors.forename: J E
authors.initials: JE
authors.lastname: Gustafson
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000166:cytology / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport / Q000235:genetics / Q000502:physiology; D002352:Carrier Proteins; D004352:Drug Resistance, Microbial / Q000235:genetics; D029968:Escherichia coli Proteins; D005057:Eukaryotic Cells / Q000187:drug effects / Q000378:metabolism; D005672:Fusidic Acid / Q000494:pharmacology; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012459:Salicylates / Q000494:pharmacology* / Q000627:therapeutic use; D016415:Sequence Alignment; D014774:Virulence / Q000187:drug effects
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D005672:Fusidic Acid; D008565:Membrane Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012459:Salicylates; C083496:AcrB protein, E coli