title: Distension of urinary bladder induces exaggerated coronary constriction in smokers with early atherosclerosis.
abstract: Distension of the urinary bladder causes an increase in efferent sympathetic activity, which can precipitate myocardial ischemia. Smoking has been shown to modulate activities of afferent nerves from the distended urinary bladder and to impair endothelial function in response to sympathetic activation. To assess the effect of bladder distension on coronary dynamics in smokers, we measured epicardial and microvascular responses in 24 patients with early atherosclerosis (< 50% diameter stenosis). Patients were classified into habitual smokers (group 1, n = 14) and nonsmokers (group 2, n = 10). Habitual smokers were randomized into two subgroups on the basis of the use of doxazosin, as follows: subgroup 1A (n = 7), without administration of doxazosin before catheterization; subgroup 1B (n = 7), with dosing doxazosin. In response to bladder distension (mean intravesical pressure 21.5 mmHg), bladder distension significantly decreased coronary diameter at the stenotic segments, coronary blood flow, and increased coronary resistance compared with baseline values, in subgroup 1A patients. In subgroup 1B patients during bladder distension, coronary diameter, coronary blood flow, and coronary resistance did not show significant changes compared with baseline values. There were significant differences of coronary diameter at the stenotic segments, coronary blood flow, and of changes of coronary vascular resistance between subgroup 1A and group 2 during bladder distension, despite similar changes in rate-pressure product. The present study showed that urinary bladder distension caused an abnormal vasomotor response of epicardial vasoconstriction and a concomitant increased coronary resistance, which leads to reduction in coronary blood flow in patients with early atherosclerosis. Smoking may further impair the response, implying that smoking has exaggerated response to sympathetic stimulation of conduit and resistance vessels. The abnormal response was abolished by pretreated administration of doxazosin, suggesting that the involved mechanisms are related to alpha(1)-adrenoceptors.
authors.affiliation: Cardiology Section, Department of Internal Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, 600 Taipei, Taiwan. tmlee@ha.mc.ntu.edu.tw
authors.forename: T M
authors.initials: TM
authors.lastname: Lee
authors.forename: S F
authors.initials: SF
authors.lastname: Su
authors.forename: W Y
authors.initials: WY
authors.lastname: Suo
authors.forename: C Y
authors.initials: CY
authors.lastname: Lee
authors.forename: M F
authors.initials: MF
authors.lastname: Chen
authors.forename: Y T
authors.initials: YT
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Tsai
mesh_terms: D000368:Aged; D001794:Blood Pressure; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D017292:Doxazosin; D015150:Echocardiography, Doppler; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000294:innervation / Q000502:physiology; D011446:Prospective Studies; D012907:Smoking / Q000009:adverse effects / Q000503:physiopathology*; D001743:Urinary Bladder / Q000294:innervation* / Q000502:physiology*; D014563:Urodynamics / Q000502:physiology; D014655:Vascular Resistance; D014661:Vasoconstriction / Q000502:physiology*; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D017292:Doxazosin