title: Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function.
authors.affiliation: Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Nadler
authors.forename: S A
authors.initials: SA
authors.lastname: Matthews
authors.forename: H
authors.initials: H
authors.lastname: Turner
authors.forename: J P
authors.initials: JP
authors.lastname: Kinet
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000077329:Agammaglobulinaemia Tyrosine Kinase; D000595:Amino Acid Sequence; D000818:Animals; D001491:Basophils / Q000276:immunology; D001704:Biopolymers; D002352:Carrier Proteins / Q000502:physiology; D018797:Cell Cycle Proteins; D004792:Enzyme Precursors / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes / Q000502:physiology; D017493:Leukocyte Common Antigens / Q000502:physiology; D008407:Mast Cells / Q000276:immunology; D008563:Membrane Lipids / Q000378:metabolism; D021962:Membrane Microdomains / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D018448:Models, Immunological; D008969:Molecular Sequence Data; D005810:Multigene Family; D015513:Oncogene Proteins / Q000737:chemistry / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000502:physiology; D051567:Proto-Oncogene Proteins c-vav; D051381:Rats; D017455:Receptors, IgE / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship; D000072377:Syk Kinase; D019061:src-Family Kinases / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001704:Biopolymers; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes; C110810:LAT protein, human; C491734:Lat protein, mouse; D008563:Membrane Lipids; D008565:Membrane Proteins; D015513:Oncogene Proteins; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D051567:Proto-Oncogene Proteins c-vav; D017455:Receptors, IgE; C092947:SLP-76 signal Transducing adaptor proteins; C496618:VAV1 protein, human; C093651:VAV2 protein, human; C496619:Vav1 protein, mouse; C496620:Vav1 protein, rat; C490565:Vav2 protein, mouse; C490564:Vav2 protein, rat; D007073:Immunoglobulin E; C089212:protein kinase D; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000606896:SYK protein, human; D000072377:Syk Kinase; C000606897:Syk protein, mouse; C000606898:Syk protein, rat; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases; D011493:Protein Kinase C; D017493:Leukocyte Common Antigens; C516724:PTPN11 protein, human; C509249:PTPN6 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases; C516725:Ptpn11 protein, mouse; C516727:Ptpn11 protein, rat; C509248:Ptpn6 protein, mouse; C509250:Ptpn6 protein, rat