title: Transient global ischemia specifically modulates visual P300 scalp distribution.
abstract: OBJECTIVE
  Latency, amplitude, and scalp topography of the visual P300 component was examined in patients who had suffered from transient global ischemia (TGI) due to cardiac arrest and in age matched clinical and healthy controls in order to investigate the diagnostic value of this component.
  
  
  METHODS
  Event-related potentials (ERPs) were recorded from 19 scalp electrodes in a visual oddball paradigm.
  
  
  RESULTS
  Mean latency of the P300 component was prolonged in both patient groups. Changes in scalp distribution of the P300, however, appear to be specific to anoxic-ischemic encephalopathy. In particular, a selective reduction of the P300 amplitudes at posterior recording sites was observed in TGI patients. Moreover, examination of the auditory P300 in TGI patients revealed that this selective change seems to be restricted to the visual modality.
  
  
  CONCLUSIONS
  The results are discussed with respect to selective vulnerability of brain tissue to hypoxic-ischemic injury. After TGI a modality-specific subset of P300 generators, probably located in the transitional parieto-occipital and extrastriate occipital cortex, appears to be affected. It is also noted, that the visual P300 component could serve as an additional marker of TGI especially in patients who do not show neuropathological changes in structural brain images.
authors.affiliation: Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany. ullsperg@cns.mpg.de
authors.forename: M
authors.initials: M
authors.lastname: Ullsperger
authors.forename: A
authors.initials: A
authors.lastname: Mecklinger
authors.forename: G
authors.initials: G
authors.lastname: Matthes-von Cramon
authors.forename: D
authors.initials: D
authors.lastname: Yves von Cramon
mesh_terms: D000368:Aged; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008297:Male; D011930:Reaction Time / Q000502:physiology