NMR analysis of tautomerisms of active pinacidil-type potassium channel openers and a less active one.
In order to clarify the structural difference between active pinacidil-type potassium channel openers and a less active one, the tautomerisms of pinacidil derivatives 1-3 were investigated by NMR spectrometries. The predominant tautomer of the less active compound 3 was different from those of the active compounds 1 and 2.
Yoshiizumi
K
K
Chemistry, Group, R&D Laboratories, Nippon Organon K.K., Osaka, Japan. yoshiizumi.kazuya@organon.co.jp
Nakajima
F
F
Kiyoi
T
T
Kondo
H
H
D000959:Antihypertensive Agents / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020110:Pinacidil / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism*
D000959:Antihypertensive Agents; D015221:Potassium Channels; D020110:Pinacidil