Deletion of parental GST genes as a possible susceptibility factor in the etiology of infant leukemia.
Infant leukemia below the age of 12 months is a rare disease that exhibits a high frequency of 11q23 rearrangements. We assessed the presence of polymorphisms in several metabolic genes in 23 families of infants diagnosed with leukemia under 12 months of age in Italy. When polymorphism frequencies were calculated within families, frequencies of GST gene deletions were significantly higher than expected only among the parents of infants without the 11q23 rearrangement. These data suggest that the deletion of GST genes in parents may affect the risk of infant leukemia through a pathway independent of the MLL gene.
Garte
S
S
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Taioli
E
E
Crosti
F
F
Sainati
L
L
Barisone
E
E
Luciani
M
M
Jankovic
M
M
Biondi
A G
AG
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D015321:Gene Rearrangement; D020022:Genetic Predisposition to Disease; D018392:Genomic Imprinting; D005982:Glutathione Transferase / Q000235:genetics*; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000235:genetics; D007558:Italy; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011519:Proto-Oncogenes; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D007527:Isoenzymes; C497422:KMT2A protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D019392:Cytochrome P-450 CYP2E1; D019363:Cytochrome P-450 CYP1A1; D011495:Histone-Lysine N-Methyltransferase; D005982:Glutathione Transferase