title: Two cases of histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto's disease) following diffuse large B-cell lymphoma.
abstract: Histiocytic necrotizing lymphadenitis (HNL) is often mistaken for malignant lymphoma clinically and is also sometimes difficult to differentiate from lymphoma even histopathologically. In this report, we describe the first 2 reported cases of HNL following non-Hodgkin's lymphomas. The patients were 27- and 30-year-old women who developed cervical and axillary lymph node swellings, respectively, in the course of remission of diffuse large B-cell lymphoma. The affected lymph nodes showed the typical histology of HNL: irregular-shaped "necrotic" foci with histiocytes engulfing apoptotic bodies intermingled with large-sized blastic lymphocytes. These findings mimicked the partial involvement of large-cell lymphoma. However, the blastic cells were almost exclusively T cells, and numerous apoptotic bodies were present, which excluded the possibility of recurrence of diffuse large B-cell lymphoma.
authors.affiliation: Department of Pathology, Internal Medicine Okayama University Medical School, Okayama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshino
authors.forename: T
authors.initials: T
authors.lastname: Mannami
authors.forename: K
authors.initials: K
authors.lastname: Ichimura
authors.forename: K
authors.initials: K
authors.lastname: Takenaka
authors.forename: S
authors.initials: S
authors.lastname: Nose
authors.forename: I
authors.initials: I
authors.lastname: Yamadori
authors.forename: T
authors.initials: T
authors.lastname: Akagi
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D051925:CD79 Antigens; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000473:pathology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis
chemical_list: D015703:Antigens, CD; D017252:CD3 Complex; D051925:CD79 Antigens; C497881:CD79A protein, human; D011947:Receptors, Antigen, B-Cell