Activation of the coagulation system in Gulf War Illness: a potential pathophysiologic link with chronic fatigue syndrome. A laboratory approach to diagnosis.
Most symptoms of Gulf War Illness (GWI) are similar to Chronic Fatigue Syndrome (CFS) and/or Fibromyalgia (FM). We investigated whether these symptoms are associated with an activated coagulation system as has been reported in some cases of CFS/FM. The coagulation assays include activation markers of the cascade, platelet activation and hereditary risk factors. Our findings show activation of the coagulation system in GWI. This evidence of a hypercoagulable state suggests that symptoms may be due to poor blood flow and, therefore, a basis for the potential utility of anticoagulant therapy.
Hannan
K L
KL
Osceola Hospital, Kissimmee, Orlando, Florida, USA.
Berg
D E
DE
Baumzweiger
W
W
Harrison
H H
HH
Berg
L H
LH
Ramirez
R
R
Nichols
D
D
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D019411:Clinical Laboratory Techniques; D003937:Diagnosis, Differential; D015673:Fatigue Syndrome, Chronic / Q000097:blood / Q000175:diagnosis; D005356:Fibromyalgia / Q000097:blood / Q000175:diagnosis; D006801:Humans; D007107:Immune System; D018923:Persian Gulf Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D019851:Thrombophilia / Q000097:blood / Q000209:etiology; D014728:Veterans
D015415:Biomarkers