What you should know about PR3-ANCA. An introduction.
Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes and macrophages around the affected vessels. IgG class ANCA directed to proteinase 3 (PR3) of neutrophils and monocytes seem to be directly involved in the pathophysiology of vascular damage by causing excessive neutrophil activation and vessel wall destruction. PR3 and elastase are important players in the mechanisms of vascular necrosis. Methods of detecting ANCA have now been defined but are not uniformly used, even though clinical decisions heavily depend on correct ANCA results.
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Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark. ipo@ssi.dk
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology* / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D053146:Myeloblastin; D009504:Neutrophils / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D012697:Serine Endopeptidases / Q000276:immunology* / Q000378:metabolism; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D012697:Serine Endopeptidases; D053146:Myeloblastin