title: [Endemic and imported severe leptospirosis (Weil's disease) in southern Switzerland].
abstract: We report on 4 cases of severe icteric leptospirosis. Three patients developed renal failure requiring haemodialysis and one required mechanic ventilation for 10 days. On entry all patients presented with severe myalgia, particularly in the calves, jaundice, oligo-anuria and severe thrombocytopenia. In one case an acute abdomen-like presentation led to exploratory laparotomy. We believe that the abdominal pain was mainly due to rhabdomyolysis of the abdominal wall. The outcome was favorable in all cases and recovery of renal function was observed after a few days to several weeks. Three out of 4 patients were infected in southern Switzerland. This observation underscores the importance of wild and domestic animals as a leptospira reservoir. Patients presenting with acute renal failure and jaundice, but only mild-to-moderate elevation of transaminases, are suspect for leptospirosis regardless of travel to a tropical or subtropical country.
authors.affiliation: Dipartimento di medicina, Ospedale Regionale, Lugano. enbernasconi@tinet.ch
authors.forename: E
authors.initials: E
authors.lastname: Bernasconi
authors.forename: R
authors.initials: R
authors.lastname: Gayer
authors.forename: E
authors.initials: E
authors.lastname: Busolini
authors.forename: G
authors.initials: G
authors.lastname: Mombelli
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000328:Adult; D000368:Aged; D006801:Humans; D007922:Leptospirosis / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010146:Pain; D006435:Renal Dialysis; D012121:Respiration, Artificial; D013557:Switzerland; D014195:Travel; D014895:Weil Disease / Q000175:diagnosis* / Q000628:therapy*