Spinal malformations in the fetuses of HIV infected women receiving combination antiretroviral therapy and co-trimoxazole.
HIV positive women of reproductive age are increasingly treated with a combination of antiretroviral agents, with effects on the developing human fetus that are largely unknown. We report two cases of severe spinal malformations in the fetuses of women treated with combination antiretroviral therapy and co-trimoxazole.
Richardson
M P
MP
Paediatric Infectious Diseases Unit, St. George's Hospital, London SW17 0QT, UK. martin.richardson@pbh-tr.anglox.nhs.uk
Osrin
D
D
Donaghy
S
S
Brown
N A
NA
Hay
P
P
Sharland
M
M
D000014:Abnormalities, Drug-Induced; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D013131:Spine / Q000002:abnormalities*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D019380:Anti-HIV Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination