Detection of a group of risk factors in coronary disease using a new carriership analysis approach.
Carriership analysis is a statistical approach for detecting the average increase in risk (hazard ratio) for adverse time-dependent events per number of prespecified phenotypic or genotypic risk factors carried by subjects in limited-sized populations. This carriership approach was applied to phenotypic risk factor analysis in a postinfarction population, and simulated genetic modeling was performed to show how carriership analysis could be used to identify a group of oligogenic factors in common polygenic disorders.
Watelet
L F
LF
Department of Biostatistics, University of Rochester Medical Center, New York 14642, USA.
Moss
A J
AJ
Zareba
W
W
Oakes
D
D
Ryan
D
D
D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation / Q000235:genetics; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening / Q000379:methods*; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors
D015415:Biomarkers; D008055:Lipids