title: Trigeminal small-fibre dysfunction in patients with diabetes mellitus: a study with laser evoked potentials and corneal reflex.
abstract: OBJECTIVE
  To investigate trigeminal small-fibre function in patients with diabetes mellitus.
  
  
  METHODS
  In 52 diabetic patients we studied the trigeminal laser evoked potentials after stimulation of the skin bordering the lower lip. In the 21 patients with the severest peripheral nerve damage we also studied the electrically evoked corneal reflex. Both responses are mediated by small myelinated afferents.
  
  
  RESULTS
  Laser evoked potentials had a longer mean latency and lower amplitude in diabetic patients than in normal subjects (P<0.005). The abnormality frequency of the laser evoked potentials correlated with the severity of polyneuropathy (P<0.005). In contrast, the corneal reflex was normal.
  
  
  CONCLUSIONS
  Dysfunction of small afferents of the mandibular nerve is frequent in patients with diabetic polyneuropathy. We speculate that the primary cause could be segmental demyelination.
authors.affiliation: Department of Neurological Sciences, University of 'La Sapienza', Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Agostino
authors.forename: G
authors.initials: G
authors.lastname: Cruccu
authors.forename: G D
authors.initials: GD
authors.lastname: Iannetti
authors.forename: P
authors.initials: P
authors.lastname: Innocenti
authors.forename: A
authors.initials: A
authors.lastname: Romaniello
authors.forename: A
authors.initials: A
authors.lastname: Truini
authors.forename: M
authors.initials: M
authors.lastname: Manfredi
mesh_terms: D000328:Adult; D000368:Aged; D001767:Blinking / Q000502:physiology*; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D007834:Lasers; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D014276:Trigeminal Nerve / Q000503:physiopathology*