Mitochondrial genetics and disease.
Mitochondrial respiratory chain diseases are a highly diverse group of disorders whose main unifying characteristic is the impairment of mitochondrial function. As befits an organelle containing gene products encoded by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA), these diseases can be caused by inherited errors in either genome, but a surprising number are sporadic, and a few are even caused by environmental factors.
Schon
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Depts of Neurology and of Genetics and Development, Columbia University, New York, NY 10032, USA. eas3@columbia.edu
D000255:Adenosine Triphosphate / Q000378:metabolism; D019069:Cell Respiration / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D017240:Mitochondrial Myopathies / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D009154:Mutation; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics
D004272:DNA, Mitochondrial; D011506:Proteins; D000255:Adenosine Triphosphate