Tau epitopes in spinal cord neurofibrillary lesions in Chamorros of Guam.
We examined spinal cord sections from Guamanian Chamorros with or without amyotrophic lateral sclerosis or parkinsonism-dementia complex using immunohistochemistry and antibodies to epitopes that span the length of tau to characterize the tau epitope profile of neurofibrillary tangles in these spinal cords. Most (16/20) spinal cords, including some from Chamorros without documented clinical disease, contained tangles with a tau epitope profile similar to the tangles found in the forebrain and brain stem of these patients.
Schmidt
M L
ML
Center for Neurodegenerative Disease, Research, Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania Medical School, Philadelphia 19104-4283, USA.
Garruto
R
R
Chen
J
J
Lee
V M
VM
Trojanowski
J Q
JQ
D000368:Aged; D001921:Brain / Q000166:cytology / Q000473:pathology; D000939:Epitopes; D005006:Ethnicity; D005260:Female; D006141:Guam; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000473:pathology*; D016874:Neurofibrillary Tangles / Q000473:pathology*; D020734:Parkinsonian Disorders / Q000473:pathology*; D013116:Spinal Cord / Q000166:cytology* / Q000473:pathology; D016875:tau Proteins / Q000032:analysis*
D000939:Epitopes; D016875:tau Proteins