title: [Associated anomalies in lip-maxillopalatal clefts].
abstract: BACKGROUND
  Retrospective studies of cleft lip and palate patients suggest a multifactorial aetiology for this condition. Many patients exhibit multiple defects, often removed from the orofacial region. The frequency and location of such coexistent abnormalities vary between studies.
  
  
  METHODS
  A retrospective case-note study of 1,737 individuals with orofacial cleft, treated between 1974 and 1998 at our centre, was undertaken to assess the frequency of associated malformations and syndromes.
  
  
  RESULTS
  Associated malformations were found to be present in 33% of all cases investigated. In nearly one half of these individuals (48%), defects could be attributed to recognisable syndromes. Patients with isolated palatal clefts (45.6%) and those with bilateral clefts of the lip and palate (35.3%) were particularly well-represented. The following problems were observed relatively frequently: Cerebral anomalies (16%), facial anomalies (14%), heart malformations (15%), anomalies of the extremities (9%) and urogenital tract abnormalities (8%). In contrast, endocrine aberrations were identified sporadically (0.5%). A partial situs inversus was found only in one case.
  
  
  CONCLUSIONS
  As clefts of the lip and palate are frequently associated with additional malformations, the importance of thorough interdisciplinary neonatal screening cannot be over emphasised.
authors.affiliation: Klinik für Mund-, Kiefer- und Gesichtschirurgie, Zentralkrankenhaus, Bremen.
authors.forename: J
authors.initials: J
authors.lastname: Rustemeyer
authors.forename: L
authors.initials: L
authors.lastname: Günther
authors.forename: H R
authors.initials: HR
authors.lastname: Krause
authors.forename: S
authors.initials: S
authors.lastname: Petersen
authors.forename: V
authors.initials: V
authors.lastname: Thieme
authors.forename: A
authors.initials: A
authors.lastname: Bremerich
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis* / Q000235:genetics; D002971:Cleft Lip / Q000175:diagnosis* / Q000235:genetics; D002972:Cleft Palate / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D015997:Neonatal Screening; D013577:Syndrome