title: Diheteropeptin, a new substance with TGF-beta-like activity, produced by a fungus, Diheterospora chlamydosporia. I. Production, isolation and biological activities.
abstract: A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-beta-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in Mv1Lu cells with an IC50 value of 20.3 microM and inhibited histone deacetylase.
authors.affiliation: Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Masuoka
authors.forename: K
authors.initials: K
authors.lastname: Shin-Ya
authors.forename: Y B
authors.initials: YB
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Nagai
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003652:Decanoic Acids / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005285:Fermentation; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006999:Hypocreales / Q000378:metabolism*; D020128:Inhibitory Concentration 50; D010455:Peptides; D016212:Transforming Growth Factor beta / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D003652:Decanoic Acids; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D010455:Peptides; D016212:Transforming Growth Factor beta; C111146:diheteropeptin; C067070:trapoxin A