Gene expression microarray data analysis for toxicology profiling.
When dealing with thousands of genes, all potentially interesting, it is desirable to rank the genes according to their degree of participation in a physiological process. Therefore, genes with the highest Shannon entropy and ERL can be selected as the best toxicity target candidates, permitting preclinical scientists to focus their research and resources on those genes.
Cunningham
M J
MJ
Incyte Pharmaceuticals, Incorporated, Palo Alto, California 94304, USA. maryjane@incyte.com
Liang
S
S
Fuhrman
S
S
Seilhamer
J J
JJ
Somogyi
R
R
D000082:Acetaminophen / Q000494:pharmacology; D000818:Animals; D001564:Benzo(a)pyrene / Q000494:pharmacology; D002994:Clofibrate / Q000494:pharmacology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics*; D019277:Entropy; D015870:Gene Expression / Q000187:drug effects; D020869:Gene Expression Profiling; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D009929:Organ Size / Q000187:drug effects; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018675:Toxicity Tests / Q000379:methods
D012333:RNA, Messenger; D001564:Benzo(a)pyrene; D000082:Acetaminophen; D002994:Clofibrate