Chronic-intermittent hypoxia induces immediate early gene expression in the midline thalamus and epithalamus.
Chronic-intermittent hypoxia (CIH) was postulated to activate thalamic regions that are synaptically related to autonomic-related areas of the cerebral cortex. Animals exposed to CIH for 30 days exhibited c-fos labeling in paraventricular thalamic and lateral habenular nuclei. Our findings strongly suggest activation of a diencephalic network that participates in behavioral responses to chronic stress.
Sica
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Department of Medicine, Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, New York, NY 11040, USA.
Greenberg
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HE
Scharf
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SM
Ruggiero
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DA
D000818:Animals; D019261:Epithalamus / Q000378:metabolism*; D017781:Genes, Immediate-Early / Q000502:physiology*; D002534:Hypoxia, Brain / Q000235:genetics / Q000378:metabolism*; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013788:Thalamus / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos