[Estrogens--a breast cancer risk?].
Breast cancer is nowadays one of the most frequent cancers in female subjects. The highest risk factor is aging. Early age at first full-time pregnancy is in many studies associated with a reduced risk of breast cancer. Other risk factors are obesity, early menarche and late menopause. According to recent epidemiological studies and a reanalysis of all prospective studies longtime ERT and HRT are also associated with a slightly higher incidence of breast cancer. This higher incidence is, however, very limited and not associated with a higher mortality because only low grade, slowly progressing, receptor positive cancers are increased.
Braendle
W
W
Universitäts-Frauenklinik, Abteilung für gynäkologische Endokrinologie und Reproduktionsmedizin, Hamburg. braendle@uke.uni-hamburg.de
D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000009:adverse effects* / Q000494:pharmacology; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D011446:Prospective Studies; D012307:Risk Factors; D013557:Switzerland / Q000453:epidemiology
D004967:Estrogens