Culture models of neurodegenerative disease.
In order to investigate how mutant SOD1 protein or environmental exogenous stressors lead to the death of motor neurons, we have established several in vitro model systems. We describe some features of the various models in order to demonstrate the advantages and shortcomings of each system.
Figlewicz
D A
DA
Department of Neurology and Neurobiology/Anatomy, University of Rochester Medical Center, New York 14642, USA. Denise_Figlewicz@urmc.rochester.edu
Dong
L
L
Mlodzienski
M
M
Turcotte
J C
JC
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D002452:Cell Count; D048429:Cell Size / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D007150:Immunohistochemistry; D009046:Motor Neurons / Q000166:cytology / Q000187:drug effects / Q000201:enzymology / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology / Q000473:pathology; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*; D000072105:Superoxide Dismutase-1; D014162:Transfection
D000975:Antioxidants; D006133:Growth Substances; C000606290:SOD1 protein, human; C000606292:Sod1 protein, rat; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1