Recruitment of T cells to the lung in response to antigen challenge.
T-cell recruitment to the lungs is thought to represent a key step in airway allergic inflammation. T cells coordinate and amplify effector functions of antigen-specific and nonspecific proinflammatory cells, such as B cells and eosinophils. The T(H)2 cell, in particular, promotes allergic inflammation through the expression of IL-4, IL-5, and IL-13, proinflammatory cytokines that are important in the induction of B-cell switching and the promotion of eosinophil proliferation and survival. This cytokine profile has been implicated in asthma; elevations in bronchoalveolar lavage IL-4 and IL-5 levels have been observed in asthmatic patients. The recruitment of T(H) cells to the site of allergic inflammation (lung) is the subject of this review.
Hamid
Q A
QA
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Cameron
L A
LA
D000941:Antigens / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology; D002465:Cell Movement / Q000276:immunology; D006801:Humans; D008168:Lung / Q000166:cytology*; D012130:Respiratory Hypersensitivity / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology*
D000941:Antigens