Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica.
A highly potent anti-MRSA sesquiterpenoid has been isolated from Ulmus davidiana var. japonica, which has been traditionally used to treat infectious diseases in Korea. This naturally occurring antibiotic was identified as mansonone F (1). This compound has been found to be highly active specifically against MRSA and showed an MIC range of 0.39-3.13 microg/ml which is comparable to that of vancomycin.
Shin
D Y
DY
College of Pharmacy, Seoul National University, Kwanak-Gu, Korea.
Kim
H S
HS
Min
K H
KH
Hyun
S S
SS
Kim
S A
SA
Huh
H
H
Choi
E C
EC
Choi
Y H
YH
Kim
J
J
Choi
S H
SH
Kim
W B
WB
Suh
Y G
YG
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D007723:Korea; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D019441:Plant Epidermis / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D011809:Quinones; D012717:Sesquiterpenes