title: cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20).
abstract: Two splicing variants of mouse hippostasin/TLSP (PRSS20) were identified and termed brain-type and prostate-type, respectively. Mouse hippostasin/TLSP showed 76.8% identity to the human homologue. Transient expression showed that both translational products were secreted into the conditioned medium. Mouse hippostasin/TLSP was expressed preferentially in the fetal brain and the prostate, but not in the neonatal brain. The brain expressed only brain-type hippostasin/TLSP, while the prostate expressed both types.
authors.affiliation: Department of Cell BIology, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mitsui
authors.forename: A
authors.initials: A
authors.lastname: Okui
authors.forename: K
authors.initials: K
authors.lastname: Kominami
authors.forename: H
authors.initials: H
authors.lastname: Uemura
authors.forename: N
authors.initials: N
authors.lastname: Yamaguchi
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D001921:Brain / Q000196:embryology / Q000201:enzymology / Q000378:metabolism*; D019556:COS Cells; D003001:Cloning, Molecular; D017077:Culture Media, Conditioned / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics; D020224:Expressed Sequence Tags; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity; D011467:Prostate / Q000196:embryology / Q000201:enzymology / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D016415:Sequence Alignment; D017385:Sequence Homology; D012697:Serine Endopeptidases / Q000235:genetics* / Q000378:metabolism; D014162:Transfection
chemical_list: D017077:Culture Media, Conditioned; D018076:DNA, Complementary; D012333:RNA, Messenger; C114880:trypsin-like serine protease; D012697:Serine Endopeptidases