title: Expression of a truncated epidermal growth factor receptor in oral squamous cell carcinomas.
abstract: Epidermal growth factor receptor (EGFR) frequently overexpresses in cancers, including oral squamous cell carcinomas (OSCC). We previously identified a truncated EGFR (tEGFR) in human oral keratinocytes. In this study, we evaluated the prognostic value of tEGFR in 45 cases of OSCC. tEGFR expression inversely correlated with EGFR expression (r=-0.83, P<0.01), decreased with T-stage progression and lymph-node metastasis (P<0.05). The EGFR/tEGFR ratio correlated with the lymph-node metastasis (P<0.05) and survival outcome (hazard ratio =3.601; P<0.05). These results suggest that tEGFR may play an important roles in oral carcinogenesis and that the EGFR/tEGFR ratio may be a prognostic factor for OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, Okayama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kiyota
authors.forename: S
authors.initials: S
authors.lastname: Shintani
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahara
authors.forename: Y
authors.initials: Y
authors.lastname: Ueyama
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: R
authors.initials: R
authors.lastname: Todd
authors.forename: D T
authors.initials: DT
authors.lastname: Wong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010446:Peptide Fragments / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis
chemical_list: D010446:Peptide Fragments; D066246:ErbB Receptors