title: Collagen type Ialpha1 gene polymorphism in idiopathic osteoporosis in men.
abstract: OBJECTIVE
  To analyse the distribution of polymorphism of the collagen type Ialpha1 gene (COL1A1) and its relationship with bone metabolism and bone turnover in men with idiopathic osteoporosis.
  
  
  METHODS
  A total of 35 male patients with idiopathic osteoporosis, aged 50.4 +/- 10.3 yr, and 60 healthy males (controls), aged 47 +/- 17 yr, were included in the study. Serum osteocalcin, 25-hydroxyvitamin D and parathyroid hormone were determined in all patients. The COL1A1 Sp1 genotypes (SS, SS:, ss) were assessed by restriction enzyme digestion (BAL:1) of DNA amplified by the polymerase chain reaction.
  
  
  RESULTS
  Patients with idiopathic osteoporosis had a higher frequency of the s allele than men in the control group (29 vs 11%, P: = 0.003) and a higher frequency of the SS: genotype (patients, 48% SS, 46% SS:, 6% ss; controls, 80% SS, 18% SS:, 2% ss; P: = 0.003). No significant differences between genotypes were observed in serum concentrations of osteocalcin, vitamin D or parathyroid hormone among either the patients or the controls.
  
  
  CONCLUSIONS
  This study suggests that, in men with idiopathic osteoporosis, there is a high prevalence of the s allele and the SS: genotype that is unrelated to other parameters of bone metabolism.
authors.affiliation: Service of Rheumatology, Service of Clinical Biochemistry, Hormonal Laboratory and. Service of Nuclear Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Peris
authors.forename: L
authors.initials: L
authors.lastname: Alvarez
authors.forename: J
authors.initials: J
authors.lastname: Oriola
authors.forename: N
authors.initials: N
authors.lastname: Guañabens
authors.forename: A
authors.initials: A
authors.lastname: Monegal
authors.forename: M J
authors.initials: MJ
authors.lastname: de Osaba
authors.forename: J
authors.initials: J
authors.lastname: Jo
authors.forename: F
authors.initials: F
authors.lastname: Pons
authors.forename: A M
authors.initials: AM
authors.lastname: Ballesta
authors.forename: J
authors.initials: J
authors.lastname: Muñoz-Gómez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000235:genetics / Q000473:pathology; D003094:Collagen / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic
chemical_list: D003094:Collagen