Identification and cloning of a CD43-associated serine/threonine kinase.
CD43 is expressed on most hematopoetic cells and has been shown to regulate the activation and adhesion of T cells. We have cloned a serine/threonine kinase that can interact with the cytoplasmic domain of CD43. This protein is expressed in multiple tissues, including lymphoid cells. Analysis of the subcellular localization reveals it to be present in both the nucleus and the cytoplasm of the cell. The identification of this protein suggests that CD43 may mediate its biologic effects through activation of a kinase cascade, resulting in the regulation of cell growth.
Wang
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Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD; D002352:Carrier Proteins; D003001:Cloning, Molecular; D051917:Leukosialin; D051379:Mice; D008969:Molecular Sequence Data; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D012097:Repressor Proteins; D017386:Sequence Homology, Amino Acid; D012795:Sialoglycoproteins / Q000378:metabolism*; D014018:Tissue Distribution; D020798:Two-Hybrid System Techniques
D015703:Antigens, CD; D002352:Carrier Proteins; D051917:Leukosialin; D012097:Repressor Proteins; D012795:Sialoglycoproteins; C497863:Spn protein, mouse; C492003:Hipk2 protein, mouse; D017346:Protein Serine-Threonine Kinases