title: DNA-unwinding test using eukaryotic DNA topoisomerase I.
authors.affiliation: Abbott Labs, Abbott Park, IL, USA.
authors.forename: L L
authors.initials: LL
authors.lastname: Shen
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001578:Benzopyrans / Q000494:pharmacology; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D004270:DNA, Circular / Q000737:chemistry* / Q000378:metabolism*; D004278:DNA, Superhelical / Q000737:chemistry / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D004926:Escherichia coli; D004996:Ethidium / Q000494:pharmacology; D005057:Eukaryotic Cells / Q000201:enzymology*; D006027:Glycosides / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D008274:Magnesium / Q000494:pharmacology; D015394:Molecular Structure; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D010078:Oxazines / Q000494:pharmacology; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D011073:Polyamines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D004270:DNA, Circular; D004278:DNA, Superhelical; D006027:Glycosides; D010078:Oxazines; D011073:Polyamines; D011804:Quinolines; D059004:Topoisomerase I Inhibitors; D004264:DNA Topoisomerases, Type I; D004996:Ethidium; C002185:chartreusin; D008274:Magnesium; C049904:elsamicin A