title: Reduced iopromide elimination in hemodialysis with cuprophan membranes.
abstract: OBJECTIVE
  To evaluate the influence of different membrane materials on the efficiency of iopromide elimination.
  
  
  METHODS
  Twenty stable patients with chronic renal failure after coronary angiography were investigated for contrast medium elimination during hemodialysis directly after contrast medium application.
  
  
  RESULTS
  Clearance during hemodialysis with cuprophan membranes was 102 +/- 7 mg/ml in contrast to 153 +/- 4 mg/ml in polysulfone membranes. Elimination half-time was 94 +/- 5 min in cuprophan and 79 +/- 3 min in polysulfone membranes, and the elimination rate after 120 min was 59 +/- 2% and 66 +/- 1.5% respectively. Plasma clearance of iopromide was elevated in polysulfone membranes (188 +/-17 ml/min); however, not significantly different to cuprophane membranes (153 +/-11 ml/min). Accordingly, 24-h urinary iopromide excretion was reduced to 26 +/- 4 g/24 h vs. 32 +/- 7 g/24 h.
  
  
  CONCLUSIONS
  Hemodialysis for iopromide elimination with polysulfone membranes is more effective than with cuprophan membranes.
authors.affiliation: Department of Medicine, Westfalian Wilhelms University, Münster, Germany.
authors.forename: F K
authors.initials: FK
authors.lastname: Matzkies
authors.forename: H
authors.initials: H
authors.lastname: Reinecke
authors.forename: B
authors.initials: B
authors.lastname: Tombach
authors.forename: J
authors.initials: J
authors.lastname: Koeneke
authors.forename: H
authors.initials: H
authors.lastname: Hohage
authors.forename: K
authors.initials: K
authors.lastname: Kisters
authors.forename: R M
authors.initials: RM
authors.lastname: Schaefer
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives*; D003287:Contrast Media / Q000493:pharmacokinetics*; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D008567:Membranes, Artificial; D011108:Polymers; D006435:Renal Dialysis; D013450:Sulfones
chemical_list: D003287:Contrast Media; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D007472:Iohexol; C038192:iopromide; D002482:Cellulose; C009865:cuprammonium cellulose