Parallel synthesis and purification using anthracene-tagged substrates.
[reaction: see text] A new strategy for the synthesis and purification of synthetic intermediates is described using anthracene-tagged ester substrates in conjunction with an N-benzylmaleimide resin. Anthracene chemical tags permit use of standard solution-phase reaction conditions and reaction-monitoring techniques.
Wang
X
X
Department of Chemistry and Center for Streamlined Synthesis, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
Parlow
J J
JJ
Porco
J A
JA
D000873:Anthracenes / Q000138:chemical synthesis* / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007700:Kinetics; D008301:Maleimides; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D012116:Resins, Plant; D013329:Structure-Activity Relationship
D000873:Anthracenes; D004952:Esters; D007202:Indicators and Reagents; D008301:Maleimides; D012116:Resins, Plant; C102107:N-benzylmaleimide