[In vitro study of the interference of certain food components with the metabolism of aflatoxin B1].
Some compounds naturally present in food (quercetin, beta-naphthoflavone), used as food additives (butylated hydroxytoluene, sodium sulfite) or resulting from the way they were cooked (2-aminodipyrido [1,2-a; 3', 2'-d] imidazole, norharmane) can interfere with AFB1 metabolism. These interferences have been studied in vitro by evaluating the production of adducts to glutathione and by the Ames test on Salmonella typhimurium. Whereas all compounds produced a drastic decrease of the mutagenic activity, the first three only (quercetin, beta-naphthoflavone, butylated hydroxytoluene) interfered with the production of the adducts to glutathione.
Ngombo
M
M
Unité de Mutagenèse et Tératogenèse, UCL 72.37, Bruxelles, Belgique.
Rollmann
B
B
de Meester
C
C
Léonard
A
A
D016604:Aflatoxin B1 / Q000378:metabolism*; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002243:Carbolines; D002274:Carcinogens, Environmental / Q000378:metabolism*; D005503:Food Additives / Q000494:pharmacology*; D005511:Food Handling; D005520:Food Preservatives / Q000494:pharmacology; D005978:Glutathione / Q000187:drug effects* / Q000378:metabolism; D006247:Harmine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D009152:Mutagenicity Tests; D011794:Quercetin / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D013447:Sulfites / Q000494:pharmacology*; D019324:beta-Naphthoflavone / Q000494:pharmacology*
D002243:Carbolines; D002274:Carcinogens, Environmental; D005503:Food Additives; D005520:Food Preservatives; D007093:Imidazoles; D013447:Sulfites; D002084:Butylated Hydroxytoluene; D006247:Harmine; D019324:beta-Naphthoflavone; C010262:norharman; D011794:Quercetin; D016604:Aflatoxin B1; D005978:Glutathione; C023847:Glu-P-2; C025026:sodium sulfite