Quantitative evaluation of the rRNA in Alzheimer's disease.
The ribosomal RNA (rRNA) genes are located in nucleolus during active transcription and are transcribed by RNA polymerase I. This group of genes is involved in transcription and translation processes which can modulate gene expression. The association between rRNA levels and aging has been reported. In the present study, we investigated the ratio of mature rRNA 28S and 18S in peripheral blood of 15 Alzheimer's disease (AD) patients, 15 elderly healthy controls and 15 healthy young controls. Our results showed a statistically significant decrease of the mature rRNA 28S/18S ratio in AD patients when compared with the elderly and young control groups. Thus we can suggest that there is a possible change in the transcriptional or maturation process or a preferential degradation of the 28S subunit in AD.
da Silva
A M
AM
Departamento de Morfologia, Disciplina de Genética, UNIFESP Escola Paulista de Medicina, Rua Botucatu, 740, Vila Clementino-CEP 04023-900, São Paulo, Brazil.
Payão
S L
SL
Borsatto
B
B
Bertolucci
P H
PH
Smith
M A
MA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D005786:Gene Expression Regulation; D006801:Humans; D008875:Middle Aged; D012337:RNA, Ribosomal, 18S / Q000032:analysis* / Q000235:genetics*; D012339:RNA, Ribosomal, 28S / Q000032:analysis* / Q000235:genetics*
D012337:RNA, Ribosomal, 18S; D012339:RNA, Ribosomal, 28S