title: Association studies of candidate genes in bipolar disorders.
abstract: The aim of the investigation was to test genes for predisposition to bipolar affective disorder. Therefore, we studied candidate genes in a sample of unrelated patients (n = 102) and healthy controls (n = 79) of Austrian origin, searching for a possible association between polymorphic DNA markers of 5 candidate genes (serotonin transporter, 5-HTT; serotonin 2a receptor, 5-HT2a; dopamine D2 receptor, DRD2; dopamine D3 receptor, DRD3; dopamine transporter, DAT1) and bipolar disorder. There was an association between allelic and genotypic frequencies of 5-HTT and affection status (p = 0.014 and p = 0.017, respectively). However, after correction for multiple comparisons (Bonferroni), these results did not remain significant. Nevertheless, the findings might suggest that alterations in the structure of 5-HTT are involved in the pathogenesis of bipolar disorder, which could have major implications in treatment. No association between 5-HT2a, DRD2, DRD3, DAT1 and bipolar disorder was found.
authors.affiliation: Department of General Psychiatry, Vienna, Austria. angela.heiden@akh-wien.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Heiden
authors.forename: P
authors.initials: P
authors.lastname: Schüssler
authors.forename: U
authors.initials: U
authors.lastname: Itzlinger
authors.forename: F
authors.initials: F
authors.lastname: Leisch
authors.forename: J
authors.initials: J
authors.lastname: Scharfetter
authors.forename: C
authors.initials: C
authors.lastname: Gebhardt
authors.forename: K
authors.initials: K
authors.lastname: Fuchs
authors.forename: M
authors.initials: M
authors.lastname: Willeit
authors.forename: L
authors.initials: L
authors.lastname: Nilsson
authors.forename: E
authors.initials: E
authors.lastname: Miller-Reiter
authors.forename: T
authors.initials: T
authors.lastname: Stompe
authors.forename: K
authors.initials: K
authors.lastname: Meszaros
authors.forename: W
authors.initials: W
authors.lastname: Sieghart
authors.forename: K
authors.initials: K
authors.lastname: Hornik
authors.forename: S
authors.initials: S
authors.lastname: Kasper
authors.forename: H N
authors.initials: HN
authors.lastname: Aschauer
mesh_terms: D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004298:Dopamine / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D012701:Serotonin / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D005819:Genetic Markers; D012701:Serotonin; D004247:DNA; D004298:Dopamine