title: Unprecedented decline in measles morbidity and mortality in Calabar, south-eastern Nigeria.
abstract: The features of measles presenting at the University of CalabarTeaching Hospital, in south-eastern Nigeria between January 1992 to December 1996, were compared with those of a previous period (January 1984 to December 1987) in the same institution. The aim was to detect any changes in trends, morbidity and mortality from the infection in this environment. There were only 36 cases (7.2 per year) in the current period compared with 436 (109 per year) in the previous period (chi2=48.4, P<0.001). There were also highly significant falls in the incidence of malnutrition and bronchopneumonia (P<0.05) in the current period. Notably, there were no cases of dehydration or keratomalacia in the current period. The case fatality rate was 2.8% compared with 20.0% in the previous period (P<0.02). These unprecedented changes in the incidence, morbidity and mortality from measles are attributed to the continuing Expanded Programme on Immunization, oral rehydration therapy, appropriate nutritional management and vitamin A prophylaxis. With maintenance and strengthening of these strategies, the elimination of measles and measles deaths in the near future is feasible in this environment.
authors.affiliation: Department of Paediatrics, College of Medical Sciences, University of Calabar, Nigeria. emmanuel@unical.anpa.net.ng
authors.forename: E E
authors.initials: EE
authors.lastname: Ekanem
authors.forename: S O
authors.initials: SO
authors.lastname: Ochigbo
authors.forename: J U
authors.initials: JU
authors.lastname: Kwagtsule
mesh_terms: D017677:Age Distribution; D002648:Child; D002669:Child Welfare / Q000706:statistics & numerical data*; D002675:Child, Preschool; D005260:Female; D005440:Fluid Therapy; D006784:Hospitals, Teaching; D006801:Humans; D007115:Immunization Schedule; D015994:Incidence; D007223:Infant; D008297:Male; D008457:Measles / Q000401:mortality* / Q000517:prevention & control*; D008499:Medical Records; D009017:Morbidity; D009549:Nigeria / Q000453:epidemiology; D012189:Retrospective Studies; D014801:Vitamin A / Q000627:therapeutic use
chemical_list: D014801:Vitamin A