title: Tandem Aza
abstract: The alpha-hydroxyalkyl piperidine unit is common to several naturally occurring alkaloids and azasugar analogues. Polysubstituted piperidine derivatives of this kind (3), embodying four stereogenic centers, are formed in just a single operation from the highly stereocontrolled reaction of 4-borono-1-azadienes (1), maleimides, and aldehydes. This novel multicomponent reaction which affords as many as four elements of diversity should prove highly valuable in combinatorial chemistry and natural product synthesis.
authors.affiliation: Department of Chemistry, University of Alberta, Edmonton, AB, T6G 2G2 Canada.
authors.initials: J
authors.lastname: Tailor
authors.initials: DG
authors.lastname: Hall