Convenient preparation of 1-amidoindenes.
Lewis acid-catalyzed alpha-amidoalkylation of enolizable aldehydes with N-(alpha-benzotriazolyl-alpha-arylalkyl)amides followed by intramolecular Friedel-Crafts cyclization provides a convenient route to 2-substituted 1-amidoindenes.
Katritzky
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AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
Denisko
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OV
Busont
S
S
D018765:Dopamine Uptake Inhibitors / Q000138:chemical synthesis*; D007192:Indenes / Q000138:chemical synthesis*
D018765:Dopamine Uptake Inhibitors; D007192:Indenes