Lessons learned from gene transfer approaches.
Recent technological advances allow the transfer of genes to the synovial lining of joints. As well as opening novel opportunities for therapy, these techniques provide valuable new tools for the study of synovitis and other aspects of the biology of joints in health and disease. This article reviews briefly the results of experiments in which selected genes have been transferred to the knee joints of healthy rabbits and rabbits with antigen-induced arthritis.
Evans
C H
CH
Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. cevans@vms.cis.pitt.edu
Ghivizzani
S C
SC
Lechman
E R
ER
Mi
Z
Z
Jaffurs
D
D
Robbins
P D
PD
D000818:Animals; D001169:Arthritis, Experimental / Q000628:therapy*; D004195:Disease Models, Animal; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D011817:Rabbits; D013585:Synovitis / Q000628:therapy