title: [Pyoderma gangrenosum: and important differential diagnosis from wound infection. Case report of a life threatening course].
abstract: Pyoderma gangrenosum (PG) is a necrotizing and ulcerative skin disease of unknown cause. The pathogenesis is thought to be related to a defective immune response. The ulcerations appear spontaneously or after skin trauma. Development in a surgical wound can be misinterpreted as wound infection. However, in contrast to postoperative infections, treatment of PG requires immunosuppressive therapy. We report a case of PG following hip-joint surgery that was complicated by a severe life-threatening systemic inflammatory response syndrome (SIRS). Typically, wound and blood cultures were negative for pathogens. Prednisolone stopped the activity of the disease promptly.
authors.affiliation: Zentrum Anästhesiologie, Rettungs- und Intensivmedizin, Universität Göttingen.
authors.forename: C
authors.initials: C
authors.lastname: Kühn
authors.forename: C
authors.initials: C
authors.lastname: Vente
authors.forename: J
authors.initials: J
authors.lastname: Dörner
authors.forename: H
authors.initials: H
authors.lastname: Ratayski
authors.forename: H
authors.initials: H
authors.lastname: Burchardi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D017511:Pyoderma Gangrenosum / Q000175:diagnosis* / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D011239:Prednisolone