Reduced iopromide elimination in hemodialysis with cuprophan membranes.
OBJECTIVE
To evaluate the influence of different membrane materials on the efficiency of iopromide elimination.


METHODS
Twenty stable patients with chronic renal failure after coronary angiography were investigated for contrast medium elimination during hemodialysis directly after contrast medium application.


RESULTS
Clearance during hemodialysis with cuprophan membranes was 102 +/- 7 mg/ml in contrast to 153 +/- 4 mg/ml in polysulfone membranes. Elimination half-time was 94 +/- 5 min in cuprophan and 79 +/- 3 min in polysulfone membranes, and the elimination rate after 120 min was 59 +/- 2% and 66 +/- 1.5% respectively. Plasma clearance of iopromide was elevated in polysulfone membranes (188 +/-17 ml/min); however, not significantly different to cuprophane membranes (153 +/-11 ml/min). Accordingly, 24-h urinary iopromide excretion was reduced to 26 +/- 4 g/24 h vs. 32 +/- 7 g/24 h.


CONCLUSIONS
Hemodialysis for iopromide elimination with polysulfone membranes is more effective than with cuprophan membranes.
Matzkies
F K
FK
Department of Medicine, Westfalian Wilhelms University, Münster, Germany.
Reinecke
H
H
Tombach
B
B
Koeneke
J
J
Hohage
H
H
Kisters
K
K
Schaefer
R M
RM
D002482:Cellulose / Q000031:analogs & derivatives*; D003287:Contrast Media / Q000493:pharmacokinetics*; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D008567:Membranes, Artificial; D011108:Polymers; D006435:Renal Dialysis; D013450:Sulfones
D003287:Contrast Media; D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; C017662:polysulfone P 1700; D007472:Iohexol; C038192:iopromide; D002482:Cellulose; C009865:cuprammonium cellulose