Tetracycline-regulated gene expression in the brain.
The possibility of regulating individual gene activities in the mouse brain via the tetracycline-controlled transcriptional activation systems has sparked the development of novel mouse models aimed at elucidating the molecular mechanisms of brain disorders such as Huntington's, prion and Parkinson's diseases. In the past year, novel experimental strategies and methodological advances have emerged, contributing to the resolution of some of the initial limitations of these regulatory systems.
Mansuy
I M
IM
Swiss Federal Institute of Technology, Institute of Cell Biology, Eidgenössische Technische Hochschule Hönggerberg, CH-8093, Zürich, Switzerland.
Bujard
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H
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects* / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D013752:Tetracycline / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D011500:Protein Synthesis Inhibitors; D013752:Tetracycline