title: [Specific interaction of liposomes coated by insulin synthetic fragments with PC 12 cells].
abstract: The synthesized peptides represent the functionally important site for binding to insulin receptor. Amino acids of peptide I correlate with B-chain of insulin at the position B19-B26 and A-chain at the position A20-A21. Amino acids of peptide II correlate with B-chain of insulin at position B23-B26 and A-chain at the position A20-A21. It was shown, that the these peptides increased liposomal binding followed by receptor-mediated endocytosis by cells PC12.
authors.affiliation: Institute of Biomedical Chemistry RAMS, Moscow.
authors.forename: D L
authors.initials: DL
authors.lastname: Maslov
authors.forename: V N
authors.initials: VN
authors.lastname: Prozorovskiĭ
mesh_terms: D000818:Animals; D004705:Endocytosis; D007328:Insulin / Q000737:chemistry* / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry*; D016716:PC12 Cells; D019308:Palmitic Acid; D010446:Peptide Fragments / Q000737:chemistry*; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism
chemical_list: D007328:Insulin; D008081:Liposomes; D010446:Peptide Fragments; D019308:Palmitic Acid; D011972:Receptor, Insulin