Effect of epitalon on the lifespan increase in Drosophila melanogaster.
The geroprotector activity of epitalon, a synthetic tetrapeptide Ala-Glu-Asp-Gly, was studied on the Drosophila melanogaster wild strain Canton-S. The substance was added to the culture medium only at the developmental stage (from egg to larva). Epitalon significantly increased the lifespan (LS) of imagoes by 11-16% when applied at unprecedented low concentrations-from 0.001 x 10(-6) to 5 x 10(-6) wt.% of culture medium for males and from 0.01 x 10(-6) to 0.1 x 10(-6) wt.% of culture medium for females. The increase in LS did not depend on the substance dose. Effective concentrations of epitalon were 16,000-80,000,000 times lower than those of melatonin. The possible mechanisms of the antioxidant and regulatory effects of epitalon are discussed.
Khavinson
V K
VK
St. Petersburg Institute of Bioregulation and Gerontology, North-West Branch of the Russian Academy of Medical Sciences, 3 Prospect Dynamo, 197110, St. Petersburg, Russia.
Izmaylov
D M
DM
Obukhova
L K
LK
Malinin
V V
VV
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000254:growth & development; D005260:Female; D008136:Longevity / Q000187:drug effects*; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D012727:Sex Characteristics
D000975:Antioxidants; D009842:Oligopeptides; C421253:alanyl-glutamyl-aspartyl-glycine