title: Effects of environmental enrichment on gene expression in the brain.
abstract: An enriched environment is known to promote structural changes in the brain and to enhance learning and memory performance in rodents [Hebb, D. O. (1947) Am. Psychol. 2, 306-307]. To better understand the molecular mechanisms underlying these experience-dependent cognitive changes, we have used high-density oligonucleotide microarrays to analyze gene expression in the brain. Expression of a large number of genes changes in response to enrichment training, many of which can be linked to neuronal structure, synaptic plasticity, and transmission. A number of these genes may play important roles in modulating learning and memory capacity.
authors.affiliation: Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121; and the Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
authors.forename: C
authors.initials: C
authors.lastname: Rampon
authors.forename: C H
authors.initials: CH
authors.lastname: Jiang
authors.forename: H
authors.initials: H
authors.lastname: Dong
authors.forename: Y P
authors.initials: YP
authors.lastname: Tang
authors.forename: D J
authors.initials: DJ
authors.lastname: Lockhart
authors.forename: P G
authors.initials: PG
authors.lastname: Schultz
authors.forename: J Z
authors.initials: JZ
authors.lastname: Tsien
authors.forename: Y
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D015870:Gene Expression; D020869:Gene Expression Profiling; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013997:Time Factors