title: The central regulation of bone remodeling.
abstract: For a long time bone remodeling has been thought to be mainly an autocrine-paracrine phenomenon. Yet bone resorption mechanisms are under the control of hormones, suggesting that the same might be true for bone formation. The recent development of molecular endocrinology uncovers a common, central regulation of bone formation, body weight and reproduction mediated by leptin.
authors.affiliation: Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA. karsenty@bcm.tmc.edu
authors.forename: G
authors.initials: G
authors.lastname: Karsenty
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000235:genetics* / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics* / Q000502:physiology*; D006801:Humans