The common cold.
Upper respiratory tract infections are one of the most common infectious diseases in man and are mainly caused by rhinoviruses. A rhinoviral cold is characterized by a neutrophilic inflammatory reaction with relatively mild symptoms that rather result from the host inflammatory response to the virus than from a direct viral cytotoxic effect. As regulators of chemotaxis, transmigration and activators of inflammatory and immunocompetent cells, cytokines and mediators were shown to play a crucial role in the pathogenesis of a rhinovirus infection.
Van Cauwenberge
P B
PB
Dept. of Otorhinolaryngology, Ghent University Hospital, Belgium. Paul.Vancauwenberge@rug.ac.be
van Kempen
M J
MJ
Bachert
C
C
D003139:Common Cold / Q000276:immunology / Q000503:physiopathology / Q000821:virology*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology / Q000503:physiopathology; D009504:Neutrophils / Q000276:immunology; D012141:Respiratory Tract Infections / Q000276:immunology / Q000503:physiopathology / Q000821:virology*; D012229:Rhinovirus / Q000302:isolation & purification*
D018799:Intercellular Adhesion Molecule-1