title: Antiphospholipid antibody syndrome manifested as a postoperative cerebrovascular event in a child.
abstract: Perioperative cerebrovascular events are exceedingly uncommon in pediatric patients. The etiology of such problems includes emboli from intracardiac thrombi, sickle cell disease, vascular anomalies, vasculitis affecting the cerebral vasculature, and prothrombotic states. We describe a 6-year-old boy who had right-sided hemiparesis on the second postoperative day after an uneventful patch angioplasty for renal artery stenosis. Workup revealed a possible hypercoagulable state due to an anticardiolipin antibody. The pathogenesis of the anticardiolipin antibody syndrome, its clinical manifestations, diagnostic criteria, and potential treatment strategies are reviewed.
authors.affiliation: Department of Child Health, University of Missouri, Columbia 65212, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kreikemeier
authors.forename: J D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D001241:Aspirin / Q000627:therapeutic use; D020520:Brain Infarction / Q000209:etiology*; D002648:Child; D004359:Drug Therapy, Combination; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010291:Paresis / Q000209:etiology / Q000628:therapy; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011183:Postoperative Complications; D012078:Renal Artery Obstruction / Q000601:surgery
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D006493:Heparin; D001241:Aspirin