A diastereoselective synthesis of 2,4-disubstituted piperidines: scaffolds for drug discovery.
A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete control of reaction selectivity merely by changing the order of the reaction sequence. These targets provide convenient platforms for drug discovery which contain easily modified points of diversity.
Watson
P S
PS
Dupont Pharmaceuticals Company, Route 141 and Henry Clay Road, Wilmington, Delaware 19880, USA. paul.s.watson@dupontpharma.com
Jiang
B
B
Scott
B
B
D015195:Drug Design; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations; D010880:Piperidines