title: N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise.
abstract: The aim of the present study was to investigate whether fish oil supplementation was able to modulate the acute-phase response to strenuous exercise. Twenty male runners were randomized to receive supplementation (n = 10) with 6.0 g fish oil daily, containing 3.6 g n-3 polyunsaturated fatty acids (PUFA), for 6 wk or to receive no supplementation (n = 10) before participating in The Copenhagen Marathon 1998. Blood samples were collected before the race, immediately after, and 1.5 and 3 h postexercise. The fatty acid composition in blood mononuclear cells (BMNC) differed between the fish oil-supplemented and the control group, showing incorporation of n-3 PUFA and less arachidonic acid in BMNC in the supplemented group. The plasma levels of tumor necrosis factor-alpha, interleukin-6, and transforming growth factor-beta(1) peaked immediately after the run, the increase being 3-, 92-, and 1.1-fold, respectively, compared with resting samples. The level of interleukin-1 receptor antagonist peaked 1.5 h after exercise, with the increase being 87-fold. However, the cytokine levels did not differ among the two groups. Furthermore, supplementation with fish oil did not influence exercise-induced increases in leucocytes and creatine kinase. In conclusion, 6 wk of fish oil supplementation had no influence on the acute-phase response to strenuous exercise.
authors.affiliation: The Copenhagen Muscle Research Centre, DK-2200 Copenhagen, Denmark.
authors.forename: A D
authors.initials: AD
authors.lastname: Toft
authors.forename: M
authors.initials: M
authors.lastname: Thorn
authors.forename: K
authors.initials: K
authors.lastname: Ostrowski
authors.forename: S
authors.initials: S
authors.lastname: Asp
authors.forename: K
authors.initials: K
authors.lastname: Moller
authors.forename: S
authors.initials: S
authors.lastname: Iversen
authors.forename: C
authors.initials: C
authors.lastname: Hermann
authors.forename: S R
authors.initials: SR
authors.lastname: Sondergaard
authors.forename: B K
authors.initials: BK
authors.lastname: Pedersen
mesh_terms: D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D016207:Cytokines; D015525:Fatty Acids, Omega-3