title: mtv shapes the activity gradient of the Dpp morphogen through regulation of thickveins.
abstract: Drosophila wings are patterned by a morphogen, Decapentaplegic (Dpp), a member of the TGFbeta superfamily, which is expressed along the anterior and posterior compartment boundary. The distribution and activity of Dpp signaling is controlled in part by the level of expression of its major type I receptor, thickveins (tkv). The level of tkv is dynamically regulated by En and Hh. We have identified a novel gene, master of thickveins (mtv), which downregulates expression of tkv in response to Hh and En. mtv expression is controlled by En and Hh, and is complementary to tkv expression. In this report, we demonstrate that mtv integrates the activities of En and Hh that shape tkv expression pattern. Thus, mtv plays a key part of regulatory mechanism that makes the activity gradient of the Dpp morphogen.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Funakoshi
authors.forename: M
authors.initials: M
authors.lastname: Minami
authors.forename: T
authors.initials: T
authors.lastname: Tabata
mesh_terms: D000818:Animals; D004330:Drosophila / Q000196:embryology* / Q000502:physiology*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D019476:Insect Proteins / Q000502:physiology*; D009024:Morphogenesis; D009414:Nerve Growth Factors; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology; D014921:Wings, Animal / Q000196:embryology / Q000502:physiology
chemical_list: D029721:Drosophila Proteins; D019476:Insect Proteins; D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D016212:Transforming Growth Factor beta; C064196:dpp protein, Drosophila; C412165:sbb protein, Drosophila; C090169:tkv protein, Drosophila; D017346:Protein Serine-Threonine Kinases