title: Histopathological Predictors of Axillary Lymph Node Metastases in Patients with Breast Cancer.
abstract: BACKGROUND: A tumor 30 mm or less in diameter is a standard candidate for breast conserving surgery (BCS) in Japan. Axillary lymph node metastases (ALNM) is the most important prognostic factor for survival in patients with breast cancer, but the role of axillary node dissection has been controversial. Histopathological predictive factors of axillary lymph node involvement have not been established. The purpose of this study was to determine the association between the incidence of ALNM and histopathological factors by univariate and multivariate analysis METHODS: Sixty-five patients with noninvasive ductal carcinoma, and 993 patients with tumors 30 mm or less in diameter who underwent axillary dissection between 1988 and 1997 at our institute were reviewed. The association between ALNM and 13 histopathological factors (size, age, histological subtype, histological invasiveness, lymphatic invasion, vascular invasion, macroscopic classification, histological daughter mass, ductal spread, ER, PgR, p-53, and c-erbB-2) were analyzed by univariate and, when significant, by multivariate analysis. RESULTS: Only one patient with noninvasive ductal carcinoma had ALNM, and 33.1% of 993 patients with a tumor 30 mm or less in size had ALNM. Multivariate analysis identified six factors as independent predictors for ALNM: lymphatic invasion, size, histological invasiveness, macroscopic classification, age and histological daughter mass. CONCLUSION: Axillary lymph node dissection can be omitted in patients with noninvasive ductal carcinoma. Histopathological features of tumors 30 mm or less in diameter can be used to estimate the risk of ALNM, and routine axillary node dissection might be spared in selected patients at minimal risk of ALNM, if the treatment decision is not influenced by lymph node status, such as in elderly patients.
authors.affiliation: Department of Surgety, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokura-kita-ku, Kitakyushu 802-0077, Japan.
authors.initials: S
authors.lastname: Mitsuyama
authors.initials: K
authors.lastname: Anan
authors.initials: S
authors.lastname: Toyoshima
authors.initials: K
authors.lastname: Nishihara
authors.initials: Y
authors.lastname: Abe
authors.initials: T
authors.lastname: Iwashita
authors.initials: T
authors.lastname: Ihara
authors.initials: S
authors.lastname: Nakahara
authors.initials: F
authors.lastname: Katsumoto
authors.initials: K
authors.lastname: Tamae
authors.initials: R
authors.lastname: Abe
authors.initials: Y
authors.lastname: Hachitanda