title: The possible role of hepatitis A virus in the pathogenesis of atherosclerosis.
abstract: The possible association between hepatitis A virus (HAV) infection and coronary artery disease (CAD) was studied. Blood from 391 patients undergoing coronary angiography was tested for serum IgG antibodies to HAV and C-reactive protein (CRP). Of the 391 patients, 205 (52%) had anti-HAV IgG antibodies. CAD prevalence was 74% in HAV-seropositive and 52% in HAV-seronegative patients (P<.0001); significance persisted after adjustment for either traditional CAD risk factors or for risk factors plus other infectious agents (cytomegalovirus, Chlamydia pneumoniae, Helicobacter pylori, and herpes simplex virus). In addition, CRP levels were significantly higher in HAV-seropositive than in HAV-seronegative patients (P=. 013) in both univariate and multivariate analyses. Logistic regression analysis demonstrated that HAV seropositivity is an independent predictor of risk for CAD and elevated CRP levels. HAV infection is therefore associated with CAD, which raises the possibility that this virus may play a causal role in atherogenesis.
authors.affiliation: Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA.
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: A A
authors.initials: AA
authors.lastname: Quyyumi
authors.forename: J E
authors.initials: JE
authors.lastname: Norman
authors.forename: R
authors.initials: R
authors.lastname: Costello
authors.forename: G
authors.initials: G
authors.lastname: Csako
authors.forename: S E
authors.initials: SE
authors.lastname: Epstein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology* / Q000821:virology; D005260:Female; D006506:Hepatitis A / Q000097:blood / Q000150:complications*; D017957:Hepatitis A Virus, Human; D006508:Hepatitis Antibodies / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D002097:C-Reactive Protein