title: A cellular solid model for modulus reduction due to resorption of trabeculae in bone.
abstract: In osteoporotic trabecular bone, bone loss occurs by thinning and subsequent resorption of the trabeculae. In this study, we compare the effects of density reductions from uniform thinning of struts or from removal of struts in a random, open-cell, three-dimensional Voronoi structure. The results of this study, combined with those previous studies on other regular and random structures, suggest that the modulus and strength of trabecular bone are reduced more dramatically by density losses from resorption of trabeculae than by those from uniform thinning of trabeculae.
authors.affiliation: Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: S
authors.initials: S
authors.lastname: Vajjhala
authors.forename: A M
authors.initials: AM
authors.lastname: Kraynik
authors.forename: L J
authors.initials: LJ
authors.lastname: Gibson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D001862:Bone Resorption / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000473:pathology*; D008875:Middle Aged; D008954:Models, Biological; D015663:Osteoporosis, Postmenopausal / Q000473:pathology* / Q000503:physiopathology