title: Persistent efficacy of topical eprinomectin against nematode parasites in cattle.
abstract: Six studies were conducted to evaluate the persistent efficacy of eprinomectin pour-on against experimental challenges with infective nematode larvae in calves. In each study, calves were randomly assigned to one untreated group and up to four test groups, which were treated with eprinomectin at 500 microg/kg body weight at weekly intervals before single bolus challenge. The calves were necropsied approximately 4 weeks after challenge infection for nematode recovery. Eprinomectin pour-on provided > or =90% efficacy against challenge with Haemonchus placei, Trichostrongylus axei and T. colubriformis at 21 days after treatment and against Cooperia oncophora, C. punctata, C. surnabada, Dictyocaulus viviparus, Nematodirus helvetianus, Oesophagostomum radiatum and Ostertagia ostertagi at 28 days after treatment.
authors.affiliation: Merial Ltd, Iselin, NJ 08830-3077, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Cramer
authors.forename: S R
authors.initials: SR
authors.lastname: Pitt
authors.forename: S
authors.initials: S
authors.lastname: Rehbein
authors.forename: R P
authors.initials: RP
authors.lastname: Gogolewski
authors.forename: B N
authors.initials: BN
authors.lastname: Kunkle
authors.forename: W K
authors.initials: WK
authors.lastname: Langhoff
authors.forename: K G
authors.initials: KG
authors.lastname: Bond
authors.forename: A E
authors.initials: AE
authors.lastname: Maciel
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D007559:Ivermectin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D009348:Nematoda / Q000145:classification / Q000187:drug effects*; D009349:Nematode Infections / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; C101434:eprinomectin