Bioactive saponins from Swartzia schomburgkii from the suriname rainforest.
Bioassay-guided fractionation of the MeOH extract of Swartzia schomburgkii using the engineered yeast strains 1138, 1140, and 1353 as the bioassay tool resulted in the isolation of five active (2, 4-7) and three inactive (1, 3, 8) saponins. Saponins 4 and 6 are previously unreported. The structures of all of the saponins were established based on 1D and 2D NMR spectral analysis, on acid and alkaline hydrolysis followed by TLC and GC-MS, and by comparison with literature data for known compounds. Three of the isolated compounds (4-6) showed weak cytotoxicity against the M-109 cell line.
Abdel-Kader
M S
MS
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
Bahler
B D
BD
Malone
S
S
Werkhoven
M C
MC
Wisse
J H
JH
Neddermann
K M
KM
Bursuker
I
I
Kingston
D G
DG
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000032:analysis* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013532:Suriname; D014407:Tumor Cells, Cultured
D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins