Effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia.
A 40-year-old patient being treated for schizophrenia developed elevated plasma levels of haloperidol (HAL) in combination with chlorpromazine (CPZ) and during overlap treatment with clozapine. Competitive inhibition of HAL by first CPZ and then clozapine is discussed as a possible mechanism.
Allen
S A
SA
Colorado Mental Health Institute, Pueblo 81003, USA.
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D003024:Clozapine / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006220:Haloperidol / Q000097:blood*; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D003024:Clozapine; D006220:Haloperidol; D002746:Chlorpromazine