title: Mal de Meleda: a review of Turkish reports.
abstract: Keratoderma Palmoplantare Transgrediens or mal de Meleda (MDM) is a very rare, inherited disorder. Its name derives from the island of Meleda. Although, MDM has been reported from many different countries, only two Turkish patients with MDM have been reported in the international literature. Our six cases of MDM are reported, and retrospective analysis of published Turkish patients with MDM is included. We review the clinical characteristics, associated findings, consanguinity, and family history of the cases. In total, 26 Turkish cases of MDM including ours have been documented. Ten cases showed various nail abnormalities, the most common associated feature. We add 24 new cases from Turkey to the list in the literature. Our findings suggest that the MDM gene may also have originated elsewhere than in Mljet.
authors.affiliation: Akdeniz University School of Medicine, Department of Dermatology, Antalya, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Ayman
authors.forename: O
authors.initials: O
authors.lastname: Yerebakan
authors.forename: E
authors.initials: E
authors.lastname: Yilmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology; D044465:White People / Q000235:genetics