[Concentration of oxidized cholesterol forms in normal and gestational diabetic pregnancy].
OBJECTIVE
The aim of our study was to examine, if gestational diabetes mellitus had influence on cholesterol oxidation processes.


METHODS
Examined patients were divided into two groups: 35 patients with gestational diabetes mellitus and 24 health pregnant women. Oxycholesterols were estimated by thin layer chromatography.


RESULTS
Among substances examined in our study we stated considerable levels of 5 alpha,6 alpha-epoxycholesterol and 5 beta,6 beta-epoxycholesterol: average 3.28 micrograms/ml for pregnant women with gestational diabetes mellitus and 4.03 micrograms/ml for control group. Besides we obtained statistically important increase of 7-hydroxycholesterols concentration and epoxycholesterols sum level at third trimester of pregnancy in comparison with values for the second trimester.


CONCLUSIONS
Obtained results suggest that in pregnancy cholesterol oxidation processes are intensified, especially at the third trimester. The authors thing, that oxycholesterols can be valuable supplement examined biochemical markers at different states of pregnant pathology.
Bodzek
P
P
Katedry i Oddziału Klinicznego Połoznictwa i Ginekologii w Bytomiu, Slaskiej Akademii Medycznej w Katowicach.
Olejek
A
A
Zamłyński
J
J
D000328:Adult; D002789:Cholesterol Oxidase / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D016640:Diabetes, Gestational / Q000201:enzymology*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D011247:Pregnancy
D002789:Cholesterol Oxidase