title: Low-density lipoprotein apheresis therapy during pregnancy.
abstract: Pregnancy in patients with severe hypercholesterolemia and coronary artery disease results in multiple problems both for mother and fetus; the most potent agents for low-density lipoprotein (LDL) cholesterol reduction, the HMG-CoA reductase inhibitors (statins) cannot be used during pregnancy. We present a case in which LDL apheresis via heparin-induced extracorporeal LDL precipitation was employed safely and efficaciously during pregnancy in a woman with heterozygous familial hypercholesterolemia and stable coronary artery disease.
authors.affiliation: Boston Heart Foundation and Harvard/MIT, Cambridge, Massachusetts 02142, USA.
authors.forename: L
authors.initials: L
authors.lastname: Cashin-Hemphill
authors.forename: M
authors.initials: M
authors.lastname: Noone
authors.forename: J F
authors.initials: JF
authors.lastname: Abbott
authors.forename: C A
authors.initials: CA
authors.lastname: Waksmonski
authors.forename: R S
authors.initials: RS
authors.lastname: Lees
mesh_terms: D000328:Adult; D001781:Blood Component Removal / Q000379:methods*; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000209:etiology; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000150:complications / Q000628:therapy*; D007751:Labor, Induced; D009203:Myocardial Infarction / Q000209:etiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood* / Q000628:therapy*; D011256:Pregnancy Outcome; D016896:Treatment Outcome
chemical_list: D008078:Cholesterol, LDL