Over-expression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer.
Breast cancer is a major cause of cancer-related death in women. BRCA1 tumour-suppressor function is abolished in sporadic breast cancer by down-regulation of the protein level. This down-regulation inversely correlates with tumour grading. BRCA1 is part of a multiprotein complex, which also contains the recombination factor Rad51. Here we describe that in contrast to BRCA1, histological grading of sporadic invasive ductal breast cancer significantly correlates with over-expression of wild-type Rad51. These data suggest that in addition to the absence of the tumour-suppressor protein BRCA1, over-expression of wild-type Rad51 also contributes to the pathogenesis of a significant percentage of sporadic breast cancers and that other mechanisms than mutations must be responsible for this altered expression.
Maacke
H
H
Institute for Human Genetics, Medical University of Lübeck, Lübeck, Germany.
Opitz
S
S
Jost
K
K
Hamdorf
W
W
Henning
W
W
Krüger
S
S
Feller
A C
AC
Lopens
A
A
Diedrich
K
K
Schwinger
E
E
Stürzbecher
H W
HW
D019313:BRCA1 Protein / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology*; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D004586:Electrophoresis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009367:Neoplasm Staging; D051135:Rad51 Recombinase; D015854:Up-Regulation
D019313:BRCA1 Protein; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; C495153:RAD51 protein, human; D051135:Rad51 Recombinase