Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study.
A genetic linkage study of young-onset hypertension was performed on data from 59 nucleus families of Han Chinese residing in Taiwan. Thirty seven microsatellite markers near 18 hypertension candidate genes were genotyped. In a nonparametric identity-by-descent sibpair analysis, a positive linkage signal (defined as P<0.05) was found for four microsatellite markers, viz., D1S1612 (P=0.0162), D1S547 (P=0.0263), D8S 1145 (P= 0.0284), and D17S2193 (P=0.0256), which were located near genes for atrial natriuretic peptide (NPPA)/glucose transporter 5 (SLC2A5), angiotensinogen (AGT), lipoprotein lipase (LPL), and angiotensin-conveting enzyme (DCP1), respectively. Marker D5S1480 located near beta-2-adrenergic receptor (ADRB2) had a borderline P value (P=0.0785) for the positive signal. Comprehensive genotyping with further markers in these regions is underway to confirm whether these genes are linked to young-onset hypertension.
Pan
W H
WH
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. pan@ibms.sinica.edu.tw
Chen
J W
JW
Fann
C
C
Jou
Y S
YS
Wu
S Y
SY
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000808:Angiotensinogen; D009320:Atrial Natriuretic Factor / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D051296:Glucose Transporter Type 5; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008071:Lipoprotein Lipase; D018895:Microsatellite Repeats; D009004:Monosaccharide Transport Proteins; D009679:Nuclear Family; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D018709:Statistics, Nonparametric; D013624:Taiwan / Q000453:epidemiology
D005819:Genetic Markers; D051296:Glucose Transporter Type 5; D009004:Monosaccharide Transport Proteins; D000808:Angiotensinogen; D009320:Atrial Natriuretic Factor; D008071:Lipoprotein Lipase; D007703:Peptidyl-Dipeptidase A