title: Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats.
abstract: Ethnobotanical studies have revealed that Bidens pilosa is used in the traditional management of wounds and chronic gastro-duodenal ulcers. This led us to screen the methanol, cyclohexane and methylene chloride extracts of the plant for anti-ulcerogenic activity using the HCl/ethanol gastric necrotizing solution. The methylene chloride extract, which showed the highest activity (100% inhibition) at a dose of 750 mg/kg compared with the methanol and cyclohexane extracts (41 and 46% inhibition, respectively), was further tested using the indomethacin-HCl/ethanol-, absolute ethanol- and pylorus ligation-induced ulcer methods. Pre-treatment with indomethacin significantly reduced the protective effect of the extract against HCl/ethanol solution to 31%. The extract had very little gastric mucosal protection against absolute ethanol (9.8% inhibition at 750 mg/kg) compared with the controls and neither reduced gastric acid secretion in vivo nor the acidity of gastric juice following in vitro incubation.
authors.affiliation: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
authors.forename: P V
authors.initials: PV
authors.lastname: Tan
authors.forename: T
authors.initials: T
authors.lastname: Dimo
authors.forename: E
authors.initials: E
authors.lastname: Dongo
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D003510:Cyclohexanes / Q000737:chemistry; D004195:Disease Models, Animal; D007213:Indomethacin / Q000009:adverse effects; D008297:Male; D000432:Methanol / Q000737:chemistry; D008752:Methylene Chloride / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D003510:Cyclohexanes; D010936:Plant Extracts; D008752:Methylene Chloride; D007213:Indomethacin; D000432:Methanol