Cortical reafferentation following left subcortical hemorrhage: a serial functional MR study.
A 48-year-old patient who had aphasia due to a left subcortical hemorrhage underwent three follow-up examinations to assess MR signal changes accompanying recovery. A word classification task was applied. During the 6-month follow-up period, we observed a dynamic change from negative toward positive blood oxygenation level-dependent MR signals, i.e., task-related reafferentation of eloquent cortices occurred. Clinical improvement from aphasia paralleled the MR signal changes.
Hund-Georgiadis
M
M
Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany. hund@cns.mpg.de
Lex
U
U
Norris
D G
DG
von Cramon
D Y
DY
D001037:Aphasia / Q000209:etiology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping; D002543:Cerebral Hemorrhage / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012660:Semantics