Increased DNA binding specificity for antitumor ecteinascidin 743 through protein-DNA interactions?
García-Nieto
R
R
Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, and Pharma Mar, Tres Cantos, E-28760 Madrid, Spain.
Manzanares
I
I
Cuevas
C
C
Gago
F
F
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry; D004149:Dioxoles / Q000737:chemistry* / Q000378:metabolism; D051766:Early Growth Response Protein 1; D006801:Humans; D017874:Immediate-Early Proteins; D007546:Isoquinolines / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016329:Sp1 Transcription Factor / Q000737:chemistry; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin; D014157:Transcription Factors / Q000737:chemistry; D016335:Zinc Fingers
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018906:Antineoplastic Agents, Alkylating; D004268:DNA-Binding Proteins; D004149:Dioxoles; C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D017874:Immediate-Early Proteins; D007546:Isoquinolines; D016329:Sp1 Transcription Factor; D044005:Tetrahydroisoquinolines; D014157:Transcription Factors; D004247:DNA; D000077606:Trabectedin