title: [Corneal epithelial disturbance during topical use of latanoprost].
abstract: OBJECTIVE
  To report two cases with corneal epithelial disturbance during topical use of the new prostaglandin F 2 alpha derivative latanoprost and a beta-blocker.
  
  
  METHODS
  Both case 1 (82-year-old male) and case 2 (50-year-old female) were treated with topical antiglaucoma drugs for ocular hypertension.
  
  
  RESULTS
  One month (case 1) and 10 days (case 2) after treatment with topical beta-blocker and latanoprost, corneal epithelial disturbance occurred. The corneal epithelial disturbance improved over several weeks with the preservative-free artificial tears after discontinuation of latanoprost and the beta-blocker.
  
  
  CONCLUSIONS
  Careful observation is necessary during the course of treatment with latanoprost and a beta-blocker.
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Komuro
authors.forename: N
authors.initials: N
authors.lastname: Yokoi
authors.forename: S
authors.initials: S
authors.lastname: Kinoshita
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D000368:Aged; D000369:Aged, 80 and over; D019573:Epithelium, Corneal / Q000187:drug effects*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost