Comparison of Gadomer-17 and gadopentetate dimeglumine for differentiation of benign from malignant breast tumors with MR imaging.
OBJECTIVE
This study compared gadopentetate dimeglumine (molecular weight, 0.5 kD), a standard contrast medium, and Gadomer-17 (apparent molecular weight, approximately 35 kD), a new, clinically applicable, large-molecular contrast medium, with respect to their microvascular characterizations of experimentally induced breast tumors at magnetic resonance (MR) imaging.


METHODS
A spectrum of breast tumors, benign through highly malignant, was induced in Sprague-Dawley rats (n = 30) by intraperitoneal administration of N-ethyl-N-nitrosourea (ENU), a potent carcinogen. All animals underwent three-dimensional spoiled gradient-recalled MR imaging, with precontrast imaging and dynamic postcontrast imaging after injection of gadopentetate dimeglumine (0.1 mmol/kg) and Gadomer-17 (0.03 mmol/kg), administered in a random order at a 24-hour interval. Several microvascular parameters were compared: the endothelial transfer coefficient (K(PS)), a measure of microvascular permeability; the fractional plasma volume (fPV), and the plasma equivalent volume. Each MR imaging parameter was correlated with histopathologic findings.


RESULTS
With Gadomer-17, the mean values for K(PS) and fPV were significantly greater in carcinomas than in fibroadenomas (P < .004 and .04, respectively). With gadopentetate dimeglumine, the mean values for fPV and PEV were significantly greater in carcinomas (P <. 004 and .02, respectively). Because of the high variability within both fibroadenoma and carcinoma groups, however, there were no significant correlations between K(PS), fPV, or PEV and histopathologic tumor grade as indicated by the Scarff-Bloom-Richardson score, for either agent.


CONCLUSIONS
Although the K(PS) and fPV estimates obtained from dynamic MR imaging data with Gadomer-17 enhancement offer some potential for characterizing breast tumors, none of the quantitative microvascular parameters derived with either agent were significantly correlated with histopathologic tumor grade.
Daldrup-Link
H E
HE
Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California, San Francisco 94243, USA.
Shames
D M
DM
Wendland
M
M
Mühler
A
A
Gossmann
A
A
Rosenau
W
W
Brasch
R C
RC
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D003937:Diagnosis, Differential; D005038:Ethylnitrosourea; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric
D003287:Contrast Media; C402765:gadomer 17; D005682:Gadolinium; D019786:Gadolinium DTPA; D005038:Ethylnitrosourea