NKT cells: facts, functions and fallacies.
The proposed roles of NK1.1(+) T (NKT) cells in immune responses range from suppression of autoimmunity to tumor rejection. Heterogeneity of these cells contributes to the controversy surrounding their development and function. This review aims to provide an update on NKT cell biology and, whenever possible, to compare what is known about NKT-cell subsets.
Godfrey
D I
DI
Dept of Pathology and Immunology, Monash University Medical School, Commercial Road, VIC. 3181, Prahran, Australia. dale.godfrey@med.monash.edu.au
Hammond
K J
KJ
Poulton
L D
LD
Smyth
M J
MJ
Baxter
A G
AG
D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology; D005699:Galactosylceramides / Q000494:pharmacology; D006801:Humans; D007239:Infections / Q000276:immunology; D007694:Killer Cells, Natural / Q000145:classification / Q000187:drug effects / Q000276:immunology*; D008024:Ligands; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*
D000943:Antigens, Differentiation; D005699:Galactosylceramides; D008024:Ligands