title: Cigarette smoke inhalation stimulates dopaminergic neurons in rats.
abstract: In humans, nicotine is self administered by inhalation of tobacco smoke as opposed to animal models, where nicotine is administered via systemic injection. The aim of the present study was to clarify whether tobacco smoke inhalation would affect dopaminergic projections differently from the reported activation after the systemic administration of nicotine. For this purpose, tobacco smoke from cigarettes containing 1.0 or 0.1 mg nicotine was delivered by inhalation to rats, while recording from antidromically identified nigrostriatal and mesolimbic dopamine neurons. Smoke inhalation from 1.0 mg nicotine cigarettes caused a peculiar abrupt increase of discharge activity of mesolimbic dopamine neurons, while nigrostriatal cells were less responsive. This activation was promptly antagonized by mecamylamine (2.0 mg/kg, i.v.). In contrast, smoke delivered from 0.1 mg nicotine cigarettes was ineffective. These findings suggest that the boosting activation of mesolimbic dopamine neurons by inhaled nicotine might be relevant for the rewarding properties of tobacco smoking and also for the effectiveness of new treatments to stop smoking.
authors.affiliation: Neuroscienze s.c.arl, Cagliari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Fà
authors.forename: G
authors.initials: G
authors.lastname: Carcangiu
authors.forename: N
authors.initials: N
authors.lastname: Passino
authors.forename: V
authors.initials: V
authors.lastname: Ghiglieri
authors.forename: G L
authors.initials: GL
authors.lastname: Gessa
authors.forename: G
authors.initials: G
authors.lastname: Mereu
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008032:Limbic System / Q000187:drug effects / Q000502:physiology; D008464:Mecamylamine / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012906:Smoke; D012907:Smoking; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology; D014028:Tobacco Smoke Pollution
chemical_list: D012906:Smoke; D014028:Tobacco Smoke Pollution; D008464:Mecamylamine; D009538:Nicotine; D004298:Dopamine