[Influence of captopril on hemodynamics of human placenta in vitro].
OBJECTIVE
Captopril, an agiotensin converting enzyme inhibitor (ACEI) is widely used drug in antihypertensive treatment. After maternal therapy with ACEI several adverse effects on fetus and neonate have been described but the patomechanism is not well known.


METHODS
The purpose of the study was to determine the effects of varying Captopril concentrations on the perfusion pressure in fetal vessels in the in vitro placental double-sided perfusion model.


METHODS
Human placental cotyledons from term normal pregnancies were perfused with 100 ng/ml and 1000 ng/ml of Captopril. The perfusion pressure in fetal circuit in every 30 minutes of 3-hours experiment was measured.


RESULTS
The highest mean perfusion pressure in fetal circuit was observed in placentas perfused with Captopril in the dose of 100 ng/ml, whereas Captopril in the dose of 1000 ng/ml significantly decreased perfusion pressure after 180 minutes of the experiment.


CONCLUSIONS
The decrease in perfusion pressure in fetal vessels after relative high dose of Captopril may indicate its direct or indirect influence on capillaries.
Ziółkowski
C
C
Kliniki Połoznictwa i Patologii Ciazy AM w Lublinie.
Semczuk-Sikora
A
A
Skoczyński
M
M
Semczuk
M
M
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D066298:In Vitro Techniques; D010920:Placenta / Q000098:blood supply* / Q000187:drug effects*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril