Association studies of candidate genes in bipolar disorders.
The aim of the investigation was to test genes for predisposition to bipolar affective disorder. Therefore, we studied candidate genes in a sample of unrelated patients (n = 102) and healthy controls (n = 79) of Austrian origin, searching for a possible association between polymorphic DNA markers of 5 candidate genes (serotonin transporter, 5-HTT; serotonin 2a receptor, 5-HT2a; dopamine D2 receptor, DRD2; dopamine D3 receptor, DRD3; dopamine transporter, DAT1) and bipolar disorder. There was an association between allelic and genotypic frequencies of 5-HTT and affection status (p = 0.014 and p = 0.017, respectively). However, after correction for multiple comparisons (Bonferroni), these results did not remain significant. Nevertheless, the findings might suggest that alterations in the structure of 5-HTT are involved in the pathogenesis of bipolar disorder, which could have major implications in treatment. No association between 5-HT2a, DRD2, DRD3, DAT1 and bipolar disorder was found.
Heiden
A
A
Department of General Psychiatry, Vienna, Austria. angela.heiden@akh-wien.ac.at
Schüssler
P
P
Itzlinger
U
U
Leisch
F
F
Scharfetter
J
J
Gebhardt
C
C
Fuchs
K
K
Willeit
M
M
Nilsson
L
L
Miller-Reiter
E
E
Stompe
T
T
Meszaros
K
K
Sieghart
W
W
Hornik
K
K
Kasper
S
S
Aschauer
H N
HN
D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D004247:DNA / Q000235:genetics; D004298:Dopamine / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D012701:Serotonin / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
D005819:Genetic Markers; D012701:Serotonin; D004247:DNA; D004298:Dopamine