title: Quality of life after aortic valve replacement at the age of >80 years.
abstract: BACKGROUND
  The optimal management of aortic valve disease in patients >80 years old depends on functional outcome as well as operative risks and late survival.
  
  
  RESULTS
  We retrospectively identified 133 patients (62 men, 71 women) aged 80 to 91 years (mean 84+/-3 years) who underwent aortic valve replacement alone or in combination with another procedure between January 1, 1993, and April 31, 1998. Demographics included hypertension 68%, diabetes mellitus 17%, and history of stroke 11%. Operative (30 day) mortality rate was 11%. Urgent or emergent surgery, aortic insufficiency, and perioperative stroke or renal dysfunction were risk factors for operative death by multivariable analysis. Intensive care unit and total hospital length of stay were prolonged at 6.2 and 14.7 days, respectively. Late follow-up between July 1, 1998, and November 1, 1999, was 98% complete. Actuarial survival at 1 and 5 years was 80% and 55%, respectively. Predictors of late mortality were preoperative or perioperative stroke, chronic obstructive pulmonary disease, aortic stenosis, and postoperative renal dysfunction. The mean New York Heart Association functional class for 65 long-term survivors improved from 3.1 to 1.7. Quality of life assessed with the Medical Outcomes Study Short Form-36 was comparable to that predicted for the general population >75 years old.
  
  
  CONCLUSIONS
  Functional outcome after aortic valve replacement in patients >80 years old is excellent, the operative risk is acceptable, and the late survival rate is good. Surgery should not be withheld from the elderly on the basis of age alone.
authors.affiliation: Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Sundt
authors.forename: M S
authors.initials: MS
authors.lastname: Bailey
authors.forename: M R
authors.initials: MR
authors.lastname: Moon
authors.forename: E N
authors.initials: EN
authors.lastname: Mendeloff
authors.forename: C B
authors.initials: CB
authors.lastname: Huddleston
authors.forename: M K
authors.initials: MK
authors.lastname: Pasque
authors.forename: H B
authors.initials: HB
authors.lastname: Barner
authors.forename: W A
authors.initials: WA
authors.lastname: Gay
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D003710:Demography; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality; D006801:Humans; D007431:Intraoperative Complications; D007902:Length of Stay; D016015:Logistic Models; D008297:Male; D011788:Quality of Life; D012189:Retrospective Studies; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome