title: Association of lipoprotein(a), prostaglandin I(2)--synthesis stimulating plasma factor, biological half-life of prostaglandin I(2)and high-density lipoproteins in HIV-1 infection of different stages.
abstract: Patients with human immunodeficiency virus show increased atheroembolism and premature arterial events (stroke, myocardial infarction), but no increased venous thromboembolism. This paper describes an association of elevated lipoprotein(a), a decreased prostaglandin I(2)(PGI(2)) synthesis stimulating plasma factor, diminished PGI(2)-stability in plasma and decreased high-density lipoprotein-cholesterol and apolipoprotein A. It is unclear to what extent these biochemical findings represent an acute phase reaction only or a disturbance in the prostaglandin system. Definitely, they are resulting in severe hemostatic imbalance decreasing local PGI(2)-availability with a dramatic reduction in the cytoprotective capacity favouring the onset of premature arterial events seen in some of the patients.
authors.affiliation: Wilhelm Auerswald Atherosclerosis Research Group (ASF), Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Kritz
authors.forename: Y
authors.initials: Y
authors.lastname: Efthimiou
authors.forename: J
authors.initials: J
authors.lastname: Stamatopoulos
authors.forename: C
authors.initials: C
authors.lastname: Najemnik
authors.forename: H
authors.initials: H
authors.lastname: Sinzinger
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D001054:Apolipoproteins A / Q000097:blood*; D001835:Body Weight; D002478:Cells, Cultured; D008076:Cholesterol, HDL / Q000097:blood*; D004730:Endothelium, Vascular / Q000166:cytology; D011464:Epoprostenol / Q000096:biosynthesis* / Q000097:blood* / Q000493:pharmacokinetics; D005260:Female; D015658:HIV Infections / Q000097:blood*; D006679:HIV Seropositivity / Q000378:metabolism; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D017270:Lipoprotein(a) / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D017270:Lipoprotein(a); D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol