The effects of steroid hormones in HIV-related neurotoxicity: a mini review.
This review examines the interaction of steroid hormones, glucocorticoids and estrogen, and gp120, a possible causal agent of acquired immune deficiency syndrome-related dementia complex. The first part of the review examines the data and mechanisms by which gp120 may cause neurotoxicity and by which these steroid hormones effect cell death in general. The second part of the review summarizes recent experiments that show how these steroid hormones can modulate the toxic effects of gp120 and glucocorticoids exacerbating toxicity, and estrogen decreasing it. We then examine the limited in vivo and clinical data relating acquired immune deficiency syndrome-related dementia complex and steroid hormones and speculate on the possible clinical significance of these findings with respect to acquired immune deficiency syndrome-related dementia complex.
Brooke
S M
SM
Department of Biological Sciences, Stanford University, Stanford, California 94305, USA.
Sapolsky
R M
RM
D015526:AIDS Dementia Complex / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D004967:Estrogens / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D006801:Humans; D013256:Steroids / Q000627:therapeutic use*
D004967:Estrogens; D005938:Glucocorticoids; D015699:HIV Envelope Protein gp120; D013256:Steroids