title: Ancistrolikokines A-C: new 5,8'-coupled naphthylisoquinoline alkaloids from Ancistrocladus likoko.
abstract: Three new naphthylisoquinoline alkaloids, ancistrolikokines A-C (1-3), have been isolated and structurally assigned from Ancistrocladus likoko, as well as the known compound korupensamine A (4). Their 5,8'-coupling hints at a close biogenetic relationship of A. likoko to other Central African Ancistrocladus species. Compounds 1-4 showed good to moderate antimalarial activities when evaluated in vitro against the NF54 and K1 strains of Plasmodium falciparum.
authors.affiliation: Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany, Department of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka. bringham@chemie.uni-wuerzburg.de
authors.forename: G
authors.initials: G
authors.lastname: Bringmann
authors.forename: C
authors.initials: C
authors.lastname: Günther
authors.forename: W
authors.initials: W
authors.lastname: Saeb
authors.forename: J
authors.initials: J
authors.lastname: Mies
authors.forename: A
authors.initials: A
authors.lastname: Wickramasinghe
authors.forename: V
authors.initials: V
authors.lastname: Mudogo
authors.forename: R
authors.initials: R
authors.lastname: Brun
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015023:Democratic Republic of the Congo; D006801:Humans; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: C416602:Ancistrolikokine A; C416603:Ancistrolikokine B; C416604:Ancistrolikokine C; D000962:Antimalarials; D007546:Isoquinolines; D009281:Naphthalenes