[Nephrotoxicity of piperacillin combined with furosemide in rats].
Nephrotoxicity of piperacillin (PIPC) was evaluated in rats after combined administration with furosemide. After intravenous administration of PIPC (1600 mg/kg), the rats showed no change in urinalysis, biochemical analysis of plasma and histopathological analysis. The rats receiving furosemide (100 mg/kg) showed elevation of urinary NAG, BUN and creatinine concentrations, and showed slight degeneration of the renal proximal tubules. The rats receiving PIPC (1600 mg/kg) and furosemide (100 mg/kg) showed elevation of BUN and creatinine concentrations, and showed slight degeneration of the proximal tubules. These changes were comparable to those in rats receiving furosemide alone. The rats receiving cephaloridine (1600 mg/kg) showed elevation of urinary protein, BUN and creatinine concentrations, and showed moderate degeneration and necrosis of the proximal tubules. The nephrotoxicity was enhanced by combination with furosemide. In conclusion, no enhanced effect of nephrotoxicity was observed by combination of PIPC with furosemide.
Hori
R
R
Research Laboratories, Toyama Chemical Co., Ltd., Japan.
Shimakura
M
M
Aramata
Y
Y
Kizawa
K
K
Nozawa
I
I
Takahata
M
M
Minami
S
S
D000818:Animals; D002509:Cephaloridine / Q000633:toxicity; D002511:Cephalosporins / Q000633:toxicity; D004232:Diuretics / Q000008:administration & dosage* / Q000633:toxicity*; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage* / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009929:Organ Size; D010406:Penicillins / Q000008:administration & dosage* / Q000633:toxicity*; D010878:Piperacillin / Q000008:administration & dosage* / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002511:Cephalosporins; D004232:Diuretics; D010406:Penicillins; D005665:Furosemide; D002509:Cephaloridine; D010878:Piperacillin