[Evaluation of hepatic resection following hepatic arterial infusion chemotherapy for colorectal liver metastases].
We evaluated the significance of hepatectomy following hepatic arterial infusion (HAI) chemotherapy for colorectal liver metastases. The prognosis of 4 cases with initially resectable tumors was discouraging, indicating no benefit of preoperative HAI for resectable tumors. The 2- and 3-year survival of patients who underwent hepatectomy after downstaging by HAI of originally unresectable metastases were 100% and 67%, respectively, suggesting that hepatectomy combined with HAI is a promising modality for those patients. However, it seems that the control of extrahepatic disease and decision making for the timing for surgical therapy are issues requiring improvement.
Tono
T
T
Dept. of Surgery, NTT West Osaka Hospital.
Takahashi
H
H
Nakano
Y
Y
Matsushita
M
M
Ohzato
H
H
Fukunaga
M
M
Watanabe
H
H
Kanoh
Y
Y
Yasue
A
A
Okada
K
K
Hata
T
T
Iwazawa
T
T
Matsui
S
S
Yano
H
H
Kinuta
M
M
Okamura
J
J
Monden
T
T
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage
D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil