title: Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia.
abstract: OBJECTIVE
  To validate with an independent study that simple atrophy/postatrophic hyperplastic lesions (proliferative inflammatory atrophy [PIA]) often merge directly with high-grade prostatic intraepithelial neoplasia (PIN).
  
  
  METHODS
  Using radical prostatectomies (n =14), all high-grade PIN and adenocarcinoma lesions were identified. We examined the two-dimensional topographic relationship between individual high-grade PIN lesions and PIA, between carcinoma lesions and PIA, and between carcinoma lesions and high-grade PIN. To reduce the possibility that high-grade PIN lesions represented intraprostatic dissemination of carcinoma, all specimens contained total carcinoma volumes of less than 0.5 cc.
  
  
  RESULTS
  High-grade PIN merged with PIA in 267 (42.5% of high-grade PIN lesions) of 629 lesions, was adjacent in 57 lesions (9%), was near in 233 lesions (37%), and was distant from PIA in 72 lesions (11.5%). Carcinoma did not merge with PIA; it was adjacent in 24 (30. 4%) of 79 lesions, was near in 46 lesions (58.2%), and was distant from PIA in 9 lesions (11.4%). Of 79 carcinoma lesions, 18 (23%) merged with high-grade PIN, 11 (14%) were adjacent, 26 (33%) were near, and 24 (30%) were distant from high-grade PIN. Areas of presumed low-grade PIN were often found in association with high-grade PIN and PIA.
  
  
  CONCLUSIONS
  Morphologic transitions between high-grade PIN and PIA occur frequently. Although the mere topographic relation of the lesions is not definitive proof of a continuum, these results are consistent with a model in which the proliferative epithelium in PIA may progress to PIN and/or adenocarcinoma.
authors.affiliation: Departments of Pathology and Urology, Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Putzi
authors.forename: A M
authors.initials: AM
authors.lastname: De Marzo
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D001284:Atrophy; D002467:Cell Nucleus / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009385:Neoplastic Processes; D011468:Prostatectomy; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D011472:Prostatitis / Q000473:pathology; D015203:Reproducibility of Results