title: Noncompliance in organ transplant recipients: a literature review.
abstract: The consequences of failing to comply to doctor's instructions can be damaging and devastating for the individual patient and their family. Noncompliance also leads to waste, as it reduces the potential benefits of therapy, and to the extra cost of treating avoidable consequent morbidity. Life-long immunosuppression is a prerequisite for good graft function, and noncompliance is often associated with late acute rejection episodes, graft loss, and death. It might be assumed that transplant patients constitute a highly motivated group, and that compliance would be high. Unfortunately, this is not the case: overall noncompliance rates vary from 20 to 50%. This overview includes literature on heart, liver, and kidney transplants in adult and pediatric transplant patients. Compliance behavior after transplantation, noncompliance and its relationship to organ loss and death, retransplantation outcome after graft loss due to noncompliance, and reasons for postoperative noncompliance will be addressed.
authors.affiliation: Internal Medicine and Cardiology FMH, Unit for Psychosomatic and Psychosocial Medicine, Inselspital, University of Berne, Berne, Switzerland.
authors.forename: K
authors.initials: K
authors.lastname: Laederach-Hofmann
authors.forename: B
authors.initials: B
authors.lastname: Bunzel
mesh_terms: D000328:Adult; D001071:Appointments and Schedules; D004032:Diet; D015444:Exercise; D006084:Graft Rejection / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008019:Life Style; D009017:Morbidity; D009042:Motivation; D016377:Organ Transplantation / Q000009:adverse effects / Q000401:mortality / Q000523:psychology*; D019966:Substance-Related Disorders / Q000517:prevention & control; D016019:Survival Analysis; D016312:Treatment Refusal / Q000523:psychology* / Q000706:statistics & numerical data*
chemical_list: D007166:Immunosuppressive Agents