title: Revisiting the roles of mast cells in allergic rhinitis and its relation to local IgE synthesis.
abstract: Mast cells are important effector cells in the immediate-phase allergic reaction. However, in recent years much evidence has accumulated on the versatile role of mast cells in allergic inflammation. The present article is an overview of the roles of mast cells in allergic inflammation, especially in light of the local production of IgE and the IgE-IgE receptor network. Although both nasal mast cells (NMC) and T cells in allergic rhinitics are important sources of Th2-type cytokines like IL-4 and IL-13, and can induce IgE synthesis, we report here that antigen-activated NMC can secrete greater levels of IL-4/IL-13 and induce increased levels of IgE synthesis than antigen-activated nasal T cells. Furthermore, IgE production can occur locally in the nasal mucosa (target organ) and IgE itself can enhance the Fc epsilon RI expression and subsequent mediator release from NMC, thus contributing to the perpetuation of on-going allergic inflammation. Again, mast cells can contribute to the late-phase allergic reaction not only via the upregulation of adhesion molecules like VCAM-1, but also through the interactions of NMC with the extracellular matrix proteins, and interaction of NMC with nasal epithelial cells (NEC). Thus, it is increasingly evident that mast cells are not only important for the genesis of the allergic reaction, but also contribute to the late-phase allergic reaction and on-going allergic inflammation.
authors.affiliation: Department of Otolaryngology, Nippon Medical School, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Pawankar
authors.forename: S
authors.initials: S
authors.lastname: Yamagishi
authors.forename: T
authors.initials: T
authors.lastname: Yagi
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008297:Male; D008407:Mast Cells / Q000276:immunology*; D009297:Nasal Mucosa / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007073:Immunoglobulin E