title: Primary intestinal T-cell lymphoma resembling lymphomatous polyposis: report of a case.
abstract: We report an interesting case of primary intestinal T-cell lymphoma (ITL) resembling lymphomatous polyposis (LP) in a 24-year-old man. The neoplasm macroscopically showed numerous small polyps throughout the colon and microscopically showed diffuse proliferation of small-sized tumor cells with occasionally cleaved or irregularly shaped nuclei. The tumor cells were immunohistochemically positive for CD3, CD8, TIA-1, and CD56, and a polymerase chain reaction study showed a single band, indicating monoclonal rearrangement of the T-cell receptor beta gene. The phenotypic features in the current case are consistent with those of ITL derived from cytotoxic CD56+ CD8+ intraepithelial lymphocytes. This is the second documented case of primary ITL with a morphologic pattern of LP.
authors.affiliation: Department of Pathology, Saga Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Ogawa
authors.forename: N
authors.initials: N
authors.lastname: Fukushima
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Kishikawa
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
authors.forename: O
authors.initials: O
authors.lastname: Tokunaga
mesh_terms: D000328:Adult; D019002:CD56 Antigen / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D003111:Colonic Polyps / Q000473:pathology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008297:Male
chemical_list: D019002:CD56 Antigen; D016827:CD8 Antigens