Presence of apolipoprotein E epsilon4 allele in cerebral palsy.
The apolipoprotein E gene, which is located on chromosome 19, has three alleles (epsilon2, epsilon3, and epsilon4). Several recent publications associate the presence of the apolipoprotein E epsilon4 allele with the occurrence of neurologic diseases, and consider it a risk factor for the development of central nervous system affections. A group of 40 patients with cerebral palsy was studied and compared to a control group of 40 subjects, and higher occurrence of the allele epsilon4 in the group of subjects with cerebral palsy was observed. A significantly higher risk of developing cerebral palsy was demonstrated among those subjects with the apolipoprotein E epsilon4 allele.
Meirelles Kalil Pessoa de Barr
Department of Orthopaedics, School of Medicine, University of São Paulo, Brazil. pebarros@netpoint.com.br
Rodrigues
C J
CJ
de Barros
T E
TE
Bevilacqua
R G
RG
D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002547:Cerebral Palsy / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E