Regulators of membrane trafficking and Mycobacterium tuberculosis phagosome maturation block.
The biogenesis and maturation of phagosomes is an area of study which has been employing aspects of proteomic analyses and variations on that theme by identifying components on isolated organelles and following their dynamic changes and interactions with the endocytic pathway. In the case of Mycobacterium tuberculosis phagosome, the arrest of its maturation in infected macrophages, referred to in classical texts as the inhibition of phagosome-lysosome fusion, represents a phenomenon that is used to functionally dissect the phagosomal maturation pathway. In this review, we summarize the recent studies on regulators of membrane trafficking and other organelle components in the context of phagosomal biogenesis and mycobacterial phagosome maturation arrest.
Fratti
R A
RA
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109-0620, USA.
Vergne
I
I
Chua
J
J
Skidmore
J
J
Deretic
V
V
D000595:Amino Acid Sequence; D001692:Biological Transport; D015180:Electrophoresis, Gel, Two-Dimensional; D020558:GTP Phosphohydrolases / Q000378:metabolism; D008561:Membrane Fusion; D008840:Microfilament Proteins / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D010588:Phagosomes / Q000378:metabolism*; D020543:Proteome; D017386:Sequence Homology, Amino Acid
D008840:Microfilament Proteins; D020543:Proteome; C072061:coronin proteins; D020558:GTP Phosphohydrolases