[Strain-specific response in mice to the neonatal administration of ACTH(4-10) fragment: behavior, neurochemistry, and brain morphology].
Neonatal injection of the ACTH4-10 fragment (5 micrograms daily for five days) caused genotype-dependent changes in concentrations of some monoaminergic neuromediators and their metabolites in hippocampus and brain stem of adult CBA and 101/HY mice. The catecholaminergic neurons increased in number in hypothalamic zona incerta of adult 101/HY mice. Neonatal injection of the peptide caused also genotype-dependent changes in the exploratory behavior of adult animals. Sound sensitivity was reduced in the 101/HY mice, whereas no sensitivity was revealed in both control and experimental groups of the CBA mice. The effects discovered were suggested to be caused by changes in neuronal differentiation.
Shilova
O B
OB
Kol'tsov Institute of Developmental Biology, Russian Academy of Science, Moscow, Russia.
Orlova
E O
EO
Kovalev
G I
GI
Revishchin
A V
AV
Lil'p
I G
IG
Poletaeva
I I
II
Korochkin
L I
LI
D000161:Acoustic Stimulation; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D005838:Genotype; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000494:pharmacology*; D013045:Species Specificity
D015306:Biogenic Monoamines; D010446:Peptide Fragments; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10)