MR spectroscopy study of dichloroacetate treatment after ischemic stroke.
In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.
Graham
G D
GD
University of New Mexico and the Albuquerque Veterans Administration Medical Center, 87108, USA. graham@unm.edu
Barker
P B
PB
Brooks
W M
WM
Morris
D C
DC
Ahmed
W
W
Bryniarski
E
E
Hearshen
D O
DO
Sanders
J A
JA
Holshouser
B A
BA
Turkel
C C
CC
D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D003999:Dichloroacetic Acid / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D020521:Stroke / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology
D011522:Protons; D003999:Dichloroacetic Acid