[Antioxidant therapy in ischemic stroke].
The paper presents the results of investigation of emoxipin, an antioxidant synthetic drug, for treatment of patients with ischemic disorders of cerebral circulation. The drug produced a beneficial clinical effect in patients with lacunar and cardioembolic strokes of moderate severity. Therapy with emoxipin increased endogenic antioxidant activity and improved a clinical status of the patients. The protective effect of carnosine was demonstrated in experimental acute hypobaric hypoxia and cerebral ischemia in rats. The results obtained permit to recommend an inclusion of both emoxipin and carnosine in a combined treatment of ischemic disorders of cerebral circulation.
Suslina
Z A
ZA
Federova
T N
TN
Maksimova
M Iu
MIu
Riasina
T V
TV
Stvolinskiĭ
S L
SL
Khrapova
E V
EV
Boldyrev
A A
AA
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000188:drug therapy*; D002336:Carnosine / Q000627:therapeutic use*; D002560:Cerebrovascular Circulation; D006801:Humans; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats
D000975:Antioxidants; D010847:Picolines; D002336:Carnosine; C009820:6-methyl-2-ethyl-3-hydroxypyridine