title: Circadian rhythm of serum total homocysteine in men.
abstract: Serum homocysteine levels were examined in a 24-hour study of 7 healthy and 5 diabetic men, revealing a statistically significant circadian rhythm (p = 0.030), normal concentrations of 11.83 +/- 1.2 vs 12.99 +/- 1.2 micromol/L, with peak values occurring during the evening (10:37 P.M.) and lowest levels occurring during the morning. These findings imply that increased atherosclerotic risk in insulin-resistant diabetics during morning hours does not appear to be explained by differences in homocysteine levels in the normal population.
authors.affiliation: MacNeal Cardiology Group, Berwyn, Illinois 60402, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: Bremner
authors.forename: E W
authors.initials: EW
authors.lastname: Holmes
authors.forename: E L
authors.initials: EL
authors.lastname: Kanabrocki
authors.forename: R C
authors.initials: RC
authors.lastname: Hermida
authors.forename: D
authors.initials: D
authors.lastname: Ayala
authors.forename: J
authors.initials: J
authors.lastname: Garbincius
authors.forename: J L
authors.initials: JL
authors.lastname: Third
authors.forename: M D
authors.initials: MD
authors.lastname: Ryan
authors.forename: M
authors.initials: M
authors.lastname: Johnson
authors.forename: S
authors.initials: S
authors.lastname: Foley
authors.forename: P
authors.initials: P
authors.lastname: Shirazi
authors.forename: B A
authors.initials: BA
authors.lastname: Nemchausky
authors.forename: L E
authors.initials: LE
authors.lastname: Scheving
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000209:etiology; D016022:Case-Control Studies; D002940:Circadian Rhythm; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000145:classification / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D006710:Homocysteine