[The physiopathology of migraine].
Although the neurobiological causative factors are now beginning to be understood, to a large extent the complex mechanisms involved in migraine remain an enigma, with the appearance of a transient unilateral cephalic pain, possibly preceded by a protean aura and associated with several other symptoms. The factors involved include three clinical signs or symptoms, i.e., pain, the aura (focalized neurological and neurosensory signs), and accompanying symptoms (e.g., sensory, psychological, or digestive); and three anatomical sites, i.e., the brain, the meningeal or intracranial vessel and a peripheral cranial nerve, the trigeminus (V). Familial hemiplegic migraine (FHM) has led to a consideration of the genetic origin of ionic channel-dependent pathologies (channelopathies), while certain other arguments which are for the most part indirect favor the hypothesis of abnormalities, again possibly of genetic origin, in the central neurotransmitters (including serotonin), which are involved in the transmission of pain messages and in vasomotor control. However, the main point is that each of the sites involved has its specific pharmacopoeia, which can contribute towards the treatment of migraine.
Allain
H
H
Service de neurologie CHU Pontchaillou, Rennes, France.
Schück
S
S
Mauduit
N
N
Saïag
B
B
Pinel
J F
JF
Bentué-Ferrer
D
D
D006801:Humans; D007473:Ion Channels / Q000235:genetics; D008881:Migraine Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use*
D007473:Ion Channels; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists