Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator.
4-Deacetoxyagosterol A was synthesized from ergosterol by utilizing reductive regioselective epoxy cleavage as a key reaction. This synthesized congener of agosterol A, a spongean MDR-modulator. showed similar MDR-modulating activity against KB CV-60 cells overexpressing MRP.
Murakami
N
N
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Sugimoto
M
M
Morita
M
M
Akiyama
S
S
Kobayashi
M
M
D000818:Animals; D018432:Drug Resistance, Multiple; D011161:Porifera / Q000737:chemistry; D013261:Sterols / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
C420962:4-deacetoxyagosterol; D013261:Sterols