Current Concepts of Therapy for Otitis Media.
The therapy for acute otitis media is currently a topic in evolution. What was once a straightforward approach of matching middle ear pathogens to appropriate antibiotics has become a complex calculus that attempts to balance multiple terms such as spontaneous cure, emergence of resistance, pharmacokinetics-dynamics, antibiotic therapeutic efficacy, suppurative complications, and cost. This review highlights new developments in our understanding of this complex interaction of the issues surrounding a physician's decision to begin antibiotic therapy for acute otitis media.
Wientzen
RL
Pediatric Infectious Diseases, Georgetown University Children's Medical Center, 3800 Reservoir Road, NW, 2-PHC, Washington, DC 20007-2197, USA.
Barbey-Morel
C