[The effect of treatment methods on frequency of relapse in nephrotic syndrome in children].
The purpose of the work was to evaluate the influence of the treatment method in nephrotic syndrome on remission time and frequency of sickness relapse. Assessments were made in 26 children aged 1-17 years hospitalised in the Pediatric and Nephrology Department of the Military School of Medicine from 1993-1999. All children were steroid-sensitive, but only one patient didn't have relapse during the 3-years of observation. Because the most of children had oedema syndrome (92.3%) the treatment was started with intravenous hydrocortisone and continued with oral prednisone according to International Study of Kidney Disease in Children (ISKDC) criteria. 10 children with steroid-dependent syndrome were treated with intravenous methylprednisolone. Levamisole was given to 7 patients with concomitant respiratory infection. 7 other children were qualified for chlorambucil treatment. Choice of the treatment method in steroid-dependent and frequently relapsing nephrotic syndrome should be concordant with specificity of the particular patient's disease.
Goszczyk
A
A
Kliniki Pediatrii i Nefrologii Dzieciecej CSK WAM w Warszawie.
Jung
A
A
Bochniewska
V
V
Straz-Zebrowska
E
E
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002699:Chlorambucil / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D007223:Infant; D007275:Injections, Intravenous; D007978:Levamisole / Q000008:administration & dosage; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009404:Nephrotic Syndrome / Q000150:complications / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000209:etiology; D055502:Secondary Prevention
D002699:Chlorambucil; D007978:Levamisole; D011241:Prednisone; D006854:Hydrocortisone; D008775:Methylprednisolone