Insulin and raclopride combine to decrease short-term intake of sucrose solutions.
We have previously reported that the hormone insulin can modulate synaptic function of dopamine neurons. To evaluate whether insulin can alter performance of a task which is dependent on intact dopaminergic signaling, we tested rats in a five minute lick rate task, with a range of concentrations of sucrose or oil solutions. Rats received either ip (t -15 min) saline or the D2 receptor antagonist raclopride (50 microg/kg), and intraventricular (t -4 h) saline or insulin (5 mU). Although ineffective on its own, insulin combined with raclopride treatment resulted in significant suppression of sucrose lick rates compared to the saline/saline group. The overall results are consistent with our hypothesis that insulin may modify performance in tasks that are dependent on dopaminergic signaling.
Sipols
A J
AJ
Institute of Experimental and Clinical Medicine, Faculty of Medicine, University of Latvia, Riga, Latvia.
Stuber
G D
GD
Klein
S N
SN
Higgins
M S
MS
Figlewicz
D P
DP
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004347:Drug Interactions; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D020891:Raclopride / Q000494:pharmacology*; D051381:Rats
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D007328:Insulin; D020891:Raclopride; D004298:Dopamine