title: The Drosophila genome.
abstract: The past year has been a spectacular one for Drosophila research. The sequencing and annotation of the Drosophila melanogaster genome has allowed a comprehensive analysis of the first three eukaryotes to be sequenced-yeast, worm and fly-including an analysis of the fly's influences as a model for the study of human disease. This year has also seen the initiation of a full-length cDNA sequencing project and the first analysis of Drosophila development using high-density DNA microarrays containing several thousand Drosophila genes. For the first time homologous recombination has been demonstrated in flies and targeted gene disruptions may not be far off.
authors.affiliation: Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. celniker@bdgp.lbl.gov
authors.forename: S E
authors.initials: SE
authors.lastname: Celniker
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D015870:Gene Expression; D017344:Genes, Insect; D020022:Genetic Predisposition to Disease; D016678:Genome; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D011995:Recombination, Genetic
chemical_list: D019476:Insect Proteins