title: [DANAMI. A Danish study of invasive versus conservative treatment of patients with post-infarction ischemia who had received thrombolytic therapy].
abstract: BACKGROUND
  To compare an invasive strategy employing percutaneous transluminal coronary angioplasty (PTCA) or coronary artery by-pass grafting (CABG) with a medical strategy in patients who had received thrombolytic treatment for first acute myocardial infarction (AMI), and with signs of inducible ischaemia.
  
  
  METHODS
  In a prospective study 1008 patients were randomized, 503 to invasive treatment, of whom 266 (52.9%) had PTCA, and 147 (29.2%) CABG, 505 to conservative treatment, of whom eight (1.6%) were revascularized within two months.
  
  
  RESULTS
  After a median follow-up of 2.4 years the mortality in the invasive group was 3.6% vs. 4.4% (p = 0.45) in the conservative group, re-infarction incidence was 5.6% vs. 10.5% (p = 0.0038) and percentage of admissions with unstable angina was 17.9% vs. 29.5% (p < 0.00001).
  
  
  CONCLUSIONS
  We conclude that post-infarct patients with inducible ischaemia should be referred to coronary angiography and revascularised accordingly.
authors.affiliation: jkmadsen@rh.dk
authors.forename: J K
authors.initials: JK
authors.lastname: Madsen
authors.forename: P
authors.initials: P
authors.lastname: Grande
authors.forename: K
authors.initials: K
authors.lastname: Saunamäki
authors.forename: P
authors.initials: P
authors.lastname: Thayssen
authors.forename: E
authors.initials: E
authors.lastname: Kasis
authors.forename: U H
authors.initials: UH
authors.lastname: Eriksen
authors.forename: K
authors.initials: K
authors.lastname: Rasmussen
authors.forename: S
authors.initials: S
authors.lastname: Haunsø
authors.forename: T T
authors.initials: TT
authors.lastname: Nielsen
authors.forename: T H
authors.initials: TH
authors.lastname: Haghfelt
authors.forename: P F
authors.initials: PF
authors.lastname: Hansen
authors.forename: E
authors.initials: E
authors.lastname: Hjelms
authors.forename: P K
authors.initials: PK
authors.lastname: Paulsen
authors.forename: P
authors.initials: P
authors.lastname: Alstrup
authors.forename: H C
authors.initials: HC
authors.lastname: Arendrup
authors.forename: U
authors.initials: U
authors.lastname: Niebuhr-Jørgensen
authors.forename: L I
authors.initials: LI
authors.lastname: Andersen
mesh_terms: D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis; D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D003718:Denmark / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D009204:Myocardial Revascularization; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D015912:Thrombolytic Therapy; D016896:Treatment Outcome