Corticosteroids and serious cytarabine-induced pulmonary edema.
A woman with acute leukemia receiving induction chemotherapy with conventional doses of cytarabine (ARA-C) 200 mg/m2/day and daunorubicin 45 mg/m2/day developed acute respiratory distress syndrome. Respiratory failure was attributed to ARA-C primarily by exclusion and radiographic findings. She was weaned rapidly from the ventilator after receiving steroid therapy.
Larouche
G
G
Department of Pharmacy, Centre hospitalier de l'Université de Montréal, Quebec, Canada.
Denault
A
A
Prénovault
J
J
D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D003561:Cytarabine / Q000009:adverse effects* / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use*; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D008775:Methylprednisolone / Q000627:therapeutic use*; D011859:Radiography; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D005938:Glucocorticoids; D003561:Cytarabine; D008775:Methylprednisolone; D003630:Daunorubicin