title: Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports.
abstract: A replacement of the acetic acid moiety by valeric acid within the 4-hydroxymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labile resin linkage agents for use in solid phase peptide synthesis. Int. J. Peptide Protein Res. 1982; 20: 451-454) significantly improved its performance in terms of loading capacity, yield and purity of the final products. The results indicated the spacer-linker combination and type of solid supports are important factors for solid-phase synthesis.
authors.affiliation: Mimotopes Pty. Ltd., Clayton, Victoria, Australia.
authors.forename: C T
authors.initials: CT
authors.lastname: Bui
authors.forename: F
authors.initials: F
authors.lastname: Ercole
authors.forename: Y
authors.initials: Y
authors.lastname: Pham
authors.forename: R
authors.initials: R
authors.lastname: Campbell
authors.forename: F A
authors.initials: FA
authors.lastname: Rasoul
authors.forename: N J
authors.initials: NJ
authors.lastname: Maeji
authors.forename: N J
authors.initials: NJ
authors.lastname: Ede
mesh_terms: D001671:Biochemistry / Q000379:methods*; D006016:Glycolates / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D012116:Resins, Plant
chemical_list: D006016:Glycolates; D010455:Peptides; D012116:Resins, Plant; C036786:4-hydroxymethylphenoxyacetic acid