title: [Macrodiolides--chemical properties and activity in a biological model].
abstract: Diolides, often classified into a group of macrolides, represent a heterogenous group of microbial metabolites whose common feature is the presence of a cyclic diester moiety in their structure. These compounds have cytotoxic, antiviral, anthelmintic or immunosuppressive activities and they were effective agents against some autoimmune diseases. Diolides, contrary to macrolides, showed a substantially lower antibacterial activity. The current data on the chemical properties and biological activity of diolides are presented in this paper.
authors.forename: B
authors.initials: B
authors.lastname: Proksa
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D018942:Macrolides; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides