Monitoring gas exchange during a constant work rate exercise in patients with left ventricular dysfunction treated with carvedilol.
In patients with heart failure, carvedilol ameliorated cardiac function, but it did not affect oxygen uptake, kinetics, and ventilatory efficiency during 6-minute exercise at a constant 50-W workload. Persistence of respiratory incompetence may prevent improvement in submaximal oxygen uptake kinetics.
Guazzi
M
M
Istituto di Cardiologia dell Universitá degli Studi, Centro di Studio per le Richerche Cardiovascolari del Consiglio Nazionale delle Ricerche, Milan, Italy. mguazzi@cardiologicomonzino.it
Agostoni
P G
PG
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D004311:Double-Blind Method; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy* / Q000503:physiopathology
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol