[Platinum salts: cytotoxic mechanisms of action, mechanisms of resistance of cancer cells, interactions with ionizing radiation, specificity of carboplatin].
Platinum compounds primarily act by damaging cellular targets inducing direct or indirect DNA alterations, and cytoplasmic proteins modifications. Molecular and cellular mechanisms of platinum resistance include increase of DNA repair, amplification of detoxifying proteins, modification of platinum transport, and alteration of oncogenes expression. This overview will describe those preclinical constatations related to cisplatin and will focus on carboplatin specificity.
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Département d'oncologie médicale, Clinique Claude-Bernard, Metz. onco.rixe@wanadoo.fr
D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D016190:Carboplatin / Q000378:metabolism / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D018736:DNA Adducts / Q000378:metabolism; D004260:DNA Repair / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D005786:Gene Expression Regulation; D005978:Glutathione / Q000096:biosynthesis; D006801:Humans; D008668:Metallothionein / Q000378:metabolism; D009857:Oncogenes / Q000187:drug effects; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000378:metabolism
D000970:Antineoplastic Agents; D018736:DNA Adducts; D011838:Radiation-Sensitizing Agents; C057270:cisplatin-DNA adduct; D008668:Metallothionein; D016190:Carboplatin; D005978:Glutathione; D002945:Cisplatin