NF-kappaB as a therapeutic target in chronic inflammation: recent advances.
The family of nuclear factor kappaB (NF-kappaB) transcription factors is a topic of intense interest in the biomedical community stemming from the role NF-kappaB plays in almost every aspect of cell regulation: stress responses, immune cell activation, apoptosis, proliferation, differentiation and oncogenic transformation. The objective of this article is to provide an overview of recent developments in the field with an emphasis on the role of NF-kappaB in chronic inflammation, and to discuss the feasibility of therapeutic approaches based on the specific suppression of the NF-kappaB pathway.
Makarov
S S
SS
Thurston Arthritis Research Center, Center for Inflammatory Disorders, and Department of Endodontics, University of North Carolina at Chapel Hill, 27599-7280, USA. smak@med.unc.edu
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D002908:Chronic Disease; D004195:Disease Models, Animal; D017353:Gene Deletion; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D018417:Th1 Cells / Q000276:immunology; D015533:Transcriptional Activation / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D020672:I-kappa B Proteins; D016328:NF-kappa B