A scientific overview of the development of AIDS vaccines.
This article explores the development of AIDS vaccines. It briefly describes the differences between cellular and humoral immune systems and their role in HIV disease. It also considers the use of animal models in vaccine research to simulate human immune system responses to HIV. In addition, various vaccine strategies are explained. These strategies include live attenuated vaccines, subunit vaccines, live vector-based vaccines, DNA vaccines, pseudovirions, whole inactivated virus, and combination products. Advantages and disadvantages for each strategy will be described as well as the current state of progress in vaccine development. The purpose of this article is to educate nurses and other health care providers about the recent developments in vaccine technology as well as to encourage all health care providers to advocate for increased research and development of HIV-1 vaccines.
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D016915:AIDS Vaccines / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004195:Disease Models, Animal; D004992:Ethics, Medical; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D012106:Research
D016915:AIDS Vaccines