title: Menstrual-related changes in motoric function in women with Parkinson's disease.
abstract: Questionnaire studies have found that parkinsonism worsens in women during the premenstrual period, when estrogen and progesterone levels are presumably at their nadir. To assess this patient-based observation and correlate motor signs with hormonal levels, the authors prospectively studied 10 menstruating women with PD in their "off" state, on 5 successive weeks. Although PD severity fluctuated during the study period, there was no significant correlation between the objective or subjective measures of parkinsonism and estrogen and progesterone levels.
authors.affiliation: Department of Neurological Sciences, Rush-Presbyterian-St Luke's Medical Center, Rush University, Chicago, IL, USA. kkompoli@rush.edu
authors.forename: K
authors.initials: K
authors.lastname: Kompoliti
authors.forename: C L
authors.initials: CL
authors.lastname: Comella
authors.forename: J A
authors.initials: JA
authors.lastname: Jaglin
authors.forename: S
authors.initials: S
authors.lastname: Leurgans
authors.forename: R
authors.initials: R
authors.lastname: Raman
authors.forename: C G
authors.initials: CG
authors.lastname: Goetz
mesh_terms: D000328:Adult; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D010300:Parkinson Disease / Q000097:blood / Q000503:physiopathology*; D011374:Progesterone / Q000097:blood; D011795:Surveys and Questionnaires
chemical_list: D004967:Estrogens; D011374:Progesterone