title: Assessment of a genetic contribution to osteoarthritis of the hip: sibling study.
abstract: OBJECTIVE
  To study the influence of genetics on the development of hip osteoarthritis as determined by structural change on plain radiographs.
  
  
  METHODS
  Sibling study.
  
  
  METHODS
  Nottinghamshire, England.
  
  
  METHODS
  392 index participants with hip osteoarthritis of sufficient severity to warrant total hip replacement, 604 siblings of the index participants, and 1718 participants who had undergone intravenous urography.
  
  
  METHODS
  Odds ratios for hip osteoarthritis in siblings.
  
  
  RESULTS
  The age adjusted odds ratios in siblings were 4.9 (95% confidence interval, 3.9 to 6.4) for probable hip osteoarthritis and 6.4 (4.5 to 9.1) for definite hip osteoarthritis. These values were not significantly altered by adjusting for other risk factors.
  
  
  CONCLUSIONS
  Siblings have a high risk of hip osteoarthritis as shown by structural changes on plain radiographs. One explanation is that hip osteoarthritis is under strong genetic influence.
authors.affiliation: Clinical Immunology Unit, Queens Medical Centre, Nottingham NG7 2UH, UK.
authors.forename: P
authors.initials: P
authors.lastname: Lanyon
authors.forename: K
authors.initials: K
authors.lastname: Muir
authors.forename: S
authors.initials: S
authors.lastname: Doherty
authors.forename: M
authors.initials: M
authors.lastname: Doherty
mesh_terms: D017677:Age Distribution; D000368:Aged; D015992:Body Mass Index; D004739:England / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016017:Odds Ratio; D015207:Osteoarthritis, Hip / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D015995:Prevalence; D012307:Risk Factors; D014567:Urography