Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase.
A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).
Dankwardt
S M
SM
Roche Bioscience, Inflammatory Diseases Unit, Palo Alto, CA 94304, USA. sharon.dankwardt@roche.com
Billedeau
R J
RJ
Lawley
L K
LK
Abbot
S C
SC
Martin
R L
RL
Chan
C S
CS
Van Wart
H E
HE
Walker
K A
KA
D000595:Amino Acid Sequence; D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*
D019485:Bone Morphogenetic Proteins; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D008666:Metalloendopeptidases; D055395:Bone Morphogenetic Protein 1