title: Alternative transcription factor sigma(B) is involved in regulation of biofilm expression in a Staphylococcus aureus mucosal isolate.
abstract: Osmotic stress was found to induce biofilm formation in a Staphylococcus aureus mucosal isolate. Inactivation of a global regulator of the bacterial stress response, the alternative transcription factor sigma(B), resulted in a biofilm-negative phenotype and loss of salt-induced biofilm production. Complementation of the mutant strain with an expression plasmid encoding sigma(B) completely restored the wild-type phenotype. The combined data suggest a critical role of sigma(B) in S. aureus biofilm regulation under environmental stress conditions.
authors.affiliation: Institut für Molekulare Infektionsbiologie, D-97070 Würzburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Rachid
authors.forename: K
authors.initials: K
authors.lastname: Ohlsen
authors.forename: U
authors.initials: U
authors.lastname: Wallner
authors.forename: J
authors.initials: J
authors.lastname: Hacker
authors.forename: M
authors.initials: M
authors.lastname: Hecker
authors.forename: W
authors.initials: W
authors.lastname: Ziebuhr
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D018441:Biofilms / Q000254:growth & development*; D015964:Gene Expression Regulation, Bacterial; D015971:Gene Expression Regulation, Enzymologic; D009092:Mucous Membrane / Q000382:microbiology; D016254:Mutagenesis, Insertional; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics*; D012808:Sigma Factor / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; C079011:SigB protein, Bacteria; D012808:Sigma Factor; D014157:Transcription Factors; D017351:N-Acetylglucosaminyltransferases; C037649:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase