title: Interrelation of lymphocyte subpopulations in peripheral blood under cervical papillomavirus infection.
abstract: T(CD3+)-, B(CD19+)-lymphocytes and their subsets (CD4+, CD8+, CD3+ DR+, CD3- DR+) in peripheral blood of patients with CIN I, CIN II, CIN III and cancer in situ associated with HPV infection were evaluated. In peripheral blood of women with CIN II, CIN III and cancer in situ the number of T-lymphocytes which expressed CD3+ DR+ antigen decreased. In patients with CIN I, CIN III and cancer in situ the level of the CD4+ cells decreased; the level of the CD8+ cells increased. These patients had a lower CD4/CD8 ratio, the number of B cells being standard. The results may have important implications in the prognosis and immunotherapy of HPV infection.
authors.affiliation: Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kiev, Ukraine.
authors.lastname: Spivak MYa
authors.forename: V P
authors.initials: VP
authors.lastname: Lakatosh
authors.forename: L M
authors.initials: LM
authors.lastname: Lazarenko
authors.forename: L M
authors.initials: LM
authors.lastname: Lyanenko
authors.forename: M V
authors.initials: MV
authors.lastname: Azarskova
authors.forename: O M
authors.initials: OM
authors.lastname: Mikhailenko
authors.forename: L
authors.initials: L
authors.lastname: Tkáciková
authors.forename: A M
authors.initials: AM
authors.lastname: Boroda
mesh_terms: D000293:Adolescent; D000328:Adult; D016175:B-Lymphocyte Subsets / Q000276:immunology; D016516:CD4-CD8 Ratio; D002278:Carcinoma in Situ / Q000097:blood / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000097:blood / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014412:Tumor Virus Infections / Q000097:blood / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000276:immunology*; D002575:Uterine Cervicitis / Q000097:blood / Q000276:immunology*; D002578:Uterine Cervical Dysplasia / Q000097:blood / Q000276:immunology*