title: Immunogenic activity of HSV-1 temperature sensitive mutant's proteins in mono- and polyvalent systems of immunization.
abstract: Immunogenic activity of herpes simplex type 1 temperature sensitive mutant's (ts HSV-1 mutant) proteins was tested in two systems: monovalent and polyvalent with other attenuated virus strains (measles and mumps). The guinea pigs were used as animal model. In monovalent system the humoral response in animals infected with ts HSV-1 mutant (1 or 2 doses) was studied and compared to results received for HSV-1 native strain. In polyvalent system the immunological response induced by ts HSV-1 mutant in the presence of RNA virus strains was tested.
authors.affiliation: Department of Virology, National Institute of Hygiene, Warsaw, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Trzcińska
authors.forename: B
authors.initials: B
authors.lastname: Litwińska
authors.forename: M
authors.initials: M
authors.lastname: Kańtoch
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002460:Cell Line; D006168:Guinea Pigs; D000882:Haplorhini; D018259:Herpesvirus 1, Human / Q000276:immunology*; D022283:Herpesvirus Vaccines / Q000276:immunology*; D007114:Immunization; D007074:Immunoglobulin G / Q000096:biosynthesis; D009154:Mutation; D013696:Temperature; D014764:Viral Proteins / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D022283:Herpesvirus Vaccines; D007074:Immunoglobulin G; D014764:Viral Proteins