title: Hospital ventilation and risk for tuberculous infection in canadian health care workers. Canadian Collaborative Group in Nosocomial Transmission of TB.
abstract: BACKGROUND
  The risk for and determinants of transmission of tuberculosis in hospitals caring for moderate numbers of patients with tuberculosis remain uncertain.
  
  
  OBJECTIVE
  To study the association of tuberculin conversion among health care workers with ventilation of patient care areas.
  
  
  METHODS
  Cross-sectional observational survey.
  
  
  METHODS
  17 acute-care community or university hospitals.
  
  
  METHODS
  All personnel who worked at least 2 days per week in the respiratory and physiotherapy departments or in selected nursing units.
  
  
  METHODS
  Participating workers underwent tuberculin skin testing and completed self-administered questionnaires. Previous tuberculin tests and bacille Calmette-Guérin vaccinations were verified. Records of patients with tuberculosis who were hospitalized in the 3 years preceding the study were reviewed. Air exchanges per hour in patient care areas were measured by using a tracer gas technique. Multivariate proportional hazards regression was used to estimate the effect of occupational factors on documented tuberculin conversion, after adjustment for nonoccupational factors, among participants with at least one previous negative result on tuberculin skin testing.
  
  
  RESULTS
  Tuberculin conversion was associated with ventilation of general or nonisolation patient rooms of less than 2 air exchanges per hour (adjusted hazard ratio, 3.4 [95% CI, 2.1 to 5.8]); with work in moderate- to high-risk hospitals (adjusted hazard ratio, 2.2 [CI, 1.3 to 3.5]); and with work in the nursing (adjusted hazard ratio, 4.3 [CI, 2.7 to 6.9]), respiratory therapy (adjusted hazard ratio, 6.1 [CI, 3.1 to 12.0]), and physiotherapy (adjusted hazard ratio, 3.3 [CI, 1.5 to 7.2]) departments or housekeeping (adjusted hazard ratio, 4.2 [CI, 2.3 to 7.6]). Conversion was not associated with inadequate ventilation of respiratory isolation rooms (adjusted hazard ratio, 1.0 [CI, 0.8 to 1.3]).
  
  
  CONCLUSIONS
  Tuberculin conversion among health care workers was strongly associated with inadequate ventilation in general patient rooms and with type and duration of work, but not with ventilation of respiratory isolation rooms.
authors.affiliation: Montreal Chest Institute, 3650 St. Urbain Street, Montreal, Quebec H2X 2P4, Canada. menzies@meakins.lan.mcgill.ca
authors.forename: D
authors.initials: D
authors.lastname: Menzies
authors.forename: A
authors.initials: A
authors.lastname: Fanning
authors.forename: L
authors.initials: L
authors.lastname: Yuan
authors.forename: J M
authors.initials: JM
authors.lastname: FitzGerald
mesh_terms: D002170:Canada / Q000453:epidemiology; D003428:Cross Infection / Q000517:prevention & control / Q000635:transmission*; D003430:Cross-Sectional Studies; D006801:Humans; D016273:Occupational Exposure / Q000009:adverse effects; D010564:Personnel, Hospital; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control / Q000635:transmission*; D014691:Ventilation