title: Dimeric 4-aryl-1,4-dihydropyridines as novel HIV-1 protease inhibitors--affinities to intestinal P-glycoprotein.
authors.affiliation: Institut für Pharmazeutische Chemie, Martin-Luther-Universität Halle-Wittenberg, Germany. hilgeroth@pharmazie.uni-halle.de
authors.forename: A
authors.initials: A
authors.lastname: Hilgeroth
authors.forename: C
authors.initials: C
authors.lastname: Dressler
authors.forename: S
authors.initials: S
authors.lastname: Neuhoff
authors.forename: H
authors.initials: H
authors.lastname: Spahn-Langguth
authors.forename: P
authors.initials: P
authors.lastname: Langguth
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D018938:Caco-2 Cells; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D011485:Protein Binding; D011869:Radioligand Assay; D014700:Verapamil / Q000737:chemistry
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004095:Dihydropyridines; D017320:HIV Protease Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D014700:Verapamil