beta-fructosidase superfamily: homology with some alpha-L-arabinases and beta-D-xylosidases.
Comparison of the amino acid sequences of four families of glycosyl hydrolases reveals that they are homologous and have several common conserved regions. Two of these families contain beta-fructosidases (glycosyl hydrolase families GH32 and GH68) and the other two include alpha-L-arabinases and beta-xylosidases (families GH43 and GH62). The latter two families are proposed to be grouped together with the former two into the beta-fructosidase (furanosidase) superfamily. Several ORFs can be considered as a fifth family of the superfamily on the basis of sequence similarity. It is shown for the first time that a glycosyl hydrolase superfamily can include enzymes with both inversion and retention mechanism of action. Composition of the active center for enzymes of the superfamily is discussed.
Naumoff
D G
DG
State Institute for Genetics and Selection of Industrial Microorganisms, Moscow, Russia. daniil_naumoff@yahoo.com
D020134:Catalytic Domain; D017124:Conserved Sequence; D006026:Glycoside Hydrolases / Q000737:chemistry* / Q000145:classification*; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014995:Xylosidases / Q000737:chemistry*; D043324:beta-Fructofuranosidase
D006026:Glycoside Hydrolases; D014995:Xylosidases; D043324:beta-Fructofuranosidase; C026579:exo-1,4-beta-D-xylosidase; C019713:alpha-N-arabinofuranosidase