Dehydropeptides from orthogonal ligation of unprotected peptides.
A facile method has been developed to synthesize linear and cyclic dehydropeptides from unprotected peptide precursors. This method exploits an N-terminal Cys for a Cys-thioester ligation to generate an unprotected peptide and as a precursor for conversion to DeltaAla by beta-elimination under mild conditions.
Miao
Z
Z
Department of Microbiology and Immunology, Vanderbilt University, A 5119 MCN, Nashville, Tennessee 37323, USA.
Tam
J P
JP
D007202:Indicators and Reagents; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry
D007202:Indicators and Reagents; D010455:Peptides; D010456:Peptides, Cyclic