Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat.
HSP70 and heme oxygenase-1 (HO-1) are thought to be markers of cell injury and oxidative stress, respectively. We have immunolocalized these proteins in the spinal cord at 1-14 days after contusion. HSP70 and HO-1 were co-induced in glia and macrophages within the injured segment at all time points. This co-induction may reflect complementary functions that serve to protect these cells as they respond to the postcontusional environment.
Mautes
A E
AE
Neurosurgical Research Laboratory, Saarland University Medical School, Saarland, Germany.
Noble
L J
LJ
D000818:Animals; D004790:Enzyme Induction; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D051547:Heme Oxygenase-1; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D009457:Neuroglia / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000378:metabolism*
D018840:HSP70 Heat-Shock Proteins; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1