Myositis and interstitial lung disease associated with autoantibody to a transfer RNA-related protein Wa.
We describe 2 patients with myositis and interstitial lung disease with the autoantibody to Wa antigen, a 48-kDa transfer RNA-related protein. In contrast to the previous description of anti-Wa antibody, our patients lacked systemic sclerosis-related features, but had clinical features consistent with those associated with antibodies to aminoacyl-transfer RNA synthetases. The difference in clinical presentation between our patients and patients with systemic sclerosis may be explained by recognition of different epitopes on the Wa antigen.
Kajihara
M
M
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
Kuwana
M
M
Tokuda
H
H
Yamane
K
K
Kubo
M
M
Hirakata
M
M
Mimori
T
T
D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006801:Humans; D015151:Immunoblotting; D017563:Lung Diseases, Interstitial / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000276:immunology*; D011233:Precipitin Tests; D012595:Scleroderma, Systemic / Q000276:immunology
D001323:Autoantibodies; D001324:Autoantigens; C069985:Wa antigen