Interleukin-1 receptor type I gene-deficient mice are less susceptible to Staphylococcus epidermidis biomaterial-associated infection than are wild-type mice.
Elevated concentrations of interleukin-1 (IL-1) were found in tissue surrounding biomaterials infected with Staphylococcus epidermidis. To determine the role of IL-1 in biomaterial-associated infection (BAI), IL-1 receptor type I-deficient (IL-1R(-/-)) and wild-type mice received subcutaneous implants of silicon elastomer (SE) or polyvinylpyrrolidone-grafted SE (SEpvp), combined with an injection of 10(6) CFU of S. epidermidis or sterile saline. Neither mouse strain was susceptible to BAI around SE. IL-1R(-/-) mice with SEpvp implants had a no abscess formation and a reduced susceptibility to persistent S. epidermidis infection. The normal foreign body response, characterized by giant-cell formation and encapsulation, was delayed around SEpvp in wild-type mice but not in IL-1R(-/-) mice. This coincided with enhanced local IL-4 production in IL-1R(-/-) mice. These data suggest that inhibition of local IL-1 activity may be beneficial for the outcome of BAI.
Boelens
J J
JJ
Department of Pediatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands. boelensjj@yahoo.com
van der Poll
T
T
Zaat
S A
SA
Murk
J L
JL
Weening
J J
JJ
Dankert
J
J
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects*; D005549:Foreign-Body Reaction / Q000209:etiology; D007375:Interleukin-1 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000502:physiology*; D013203:Staphylococcal Infections / Q000209:etiology* / Q000473:pathology; D013212:Staphylococcus epidermidis
D001672:Biocompatible Materials; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D015847:Interleukin-4