title: Retinoblastoma-related proteins in plants: homologues or orthologues of their metazoan counterparts?
abstract: The mammalian retinoblastoma tumor suppressor protein (pRb) regulates cell division, differentiation and apoptotic pathways in specific cell types. In association with other proteins, pRb acts in part by modulating transcriptional activity. Elements of the pRb regulatory network have been identified in higher plants. Recent findings involving these proteins, which display amino acid sequence homology and biochemical binding properties analogous to their mammalian counterparts, are discussed.
authors.affiliation: Department of Plant and Microbial Biology, University of California-Berkeley, 94720, USA.
authors.forename: T
authors.initials: T
authors.lastname: Durfee
authors.forename: H S
authors.initials: HS
authors.lastname: Feiler
authors.forename: W
authors.initials: W
authors.lastname: Gruissem
mesh_terms: D000818:Animals; D017209:Apoptosis; D002352:Carrier Proteins; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D018507:Gene Expression Regulation, Developmental; D017343:Genes, Plant; D008969:Molecular Sequence Data; D010766:Phosphorylation; D063245:Plant Development; D010944:Plants / Q000235:genetics*; D016160:Retinoblastoma Protein / Q000235:genetics* / Q000378:metabolism; D056465:Retinoblastoma-Binding Protein 1; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D016160:Retinoblastoma Protein; D056465:Retinoblastoma-Binding Protein 1; D014157:Transcription Factors