title: [Healing behavior and bone regeneration of maxillary osteotomies in the experimental rabbit model. Effect of osteosynthesis and guided bone regeneration].
abstract: OBJECTIVE
  The development of fibrous nonunions following orthognathic surgery is thought to result from an interaction of biomechanical stress and the differential and more rapid migration of fibroblasts compared to osteoblasts into the wound site during healing. The present study was designed to test this hypothesis through the manipulation of guided tissue regeneration and osteotomy fixation techniques in an experimental rabbit model.
  
  
  METHODS
  Bilateral critical size (4 mm) defects (n = 24) were produced in the maxillae of 12 adult New Zealand White rabbits. The maxillary segments were rigidly or nonrigidly fixed using bone microplates and screws or osteosynthetic wires. The defects were then covered with a resorbable collagen membrane or left uncovered. The rabbits were followed for 4 weeks with serial dorsoventral and lateral oblique cephalographs and the maxillae were then harvested for histological analysis.
  
  
  RESULTS
  Radiographic and histomorphometric analysis revealed that rigidly fixed defects, covered with membrane, showed the most rapid and organized new bone formation. The rigidly fixed defects with membrane averaged approximately 40% more new bone in the osteotomy site than the rigidly fixed defects with no membrane. Nonrigidly fixed defects with no membrane also showed an ingrowth of fibroblasts and fibrous nonunions.
  
  
  CONCLUSIONS
  These results suggest that an interaction between the decreased fibrous tissue ingrowth through guided tissue regeneration and osteotomy segment stability from rigid fixation prevented postoperative fibrous nonunions and facilitated new bone regeneration and osteotomy site healing in this rabbit model.
authors.affiliation: Department of Oral Medicine & Pathology, University of Pittsburgh, PA, USA.
authors.forename: K
authors.initials: K
authors.lastname: Stetzer
authors.forename: G
authors.initials: G
authors.lastname: Cooper
authors.forename: R
authors.initials: R
authors.lastname: Gassner
authors.forename: R
authors.initials: R
authors.lastname: Kapucu
authors.forename: R
authors.initials: R
authors.lastname: Mundell
authors.forename: M
authors.initials: M
authors.lastname: Mooney
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D003094:Collagen; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D008567:Membranes, Artificial; D009984:Orthopedic Fixation Devices; D019340:Osteotomy, Le Fort; D011817:Rabbits
chemical_list: D008567:Membranes, Artificial; D003094:Collagen