[Assessment of fat tissue distribution impact on selected prothrombin and fibrinolytic factors in pre- and postmenopausal women].
OBJECTIVE
Objective was to examine the relationship of obesity, body fat distribution fasting plasma insulin concentrations and triglycerides of pro-thrombotic and fibrinolitics factors in pre and postmenopausal women.


METHODS
We assessed 24 (13 nonobese and 11 obese) postmenopausal and 44 (15 obese and 29 non obese) premenopausal women. Plasma concentration of PAI-1 ag,PAI-1 activity, fibrinogen, tPA-1 akt, tPA ag, von Willebrand factor, fasting plasma insulin, and the lipid pattern (cholesterol, TG, HDL, LDL) was measured. The body fat distribution was assessed by waist-to-hip circumference measuring.


RESULTS
Postmenopausal subjects had higher PAI-1 act. and PAI-1 ag (p < 0.05 and 0.001 respectively), vWf and lower ATIII. There was direct correlation between PAI-1 act., Fibrinogen and BMI in both groups of patients together and in premenopausal group PAI-1 act correlated directly and tPA ag/act. indirectly with plasma insulin concentrations.


CONCLUSIONS
Plasma concentrations of the pro-thrombotic factors are increased in obese and postmenopausal women and correlate directly with BMI and indirectly with plasma insulin concentrations. Plasma concentrations of anti thrombotic factors indirectly correlated with WHR and with plasma insulin concentrations.
Połać
I
I
Kliniki Ginekologii i Chorób Menopauzy Instytutu Centrum Zdrowia Matki Polki w Lodzi.
Stachowiak
G
G
Jedrzejczyk
S
S
Pertyński
T
T
Sobczuk
A
A
Pakalski
A
A
Stetkiewicz
T
T
Owczarek
D
D
D000273:Adipose Tissue / Q000502:physiology*; D000328:Adult; D015992:Body Mass Index; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology; D017698:Postmenopause; D017697:Premenopause; D011516:Prothrombin / Q000032:analysis*; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D014280:Triglycerides; D011516:Prothrombin