Cell-cycle regulation in immunity, tolerance and autoimmunity.
To trigger an effective immune response, lymphocytes must proliferate. In addition to their direct involvement in cell-cycle progression, cell-cycle regulators might thus control immune functions. Recent evidence suggests that these regulators are essential for T-cell function; we argue that their study will provide clues for dissecting anergy and tolerance mechanisms, as well as for intervention in autoimmune diseases.
Balomenos
D
D
Dept. of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, Madrid, Spain. dbalomenos@cnb.uam.es
Martínez-A
C
C
D000818:Animals; D015551:Autoimmunity; D002453:Cell Cycle / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D008213:Lymphocyte Activation; D008954:Models, Biological