[Mechanisms of enhancing UV lihg-induced lipid peroxidation in isolated erythrocyte membranes by organohalogen compounds].
It was found that a number of halogen-containing compounds (chloroform, carbon tetrachloride, difluorodichloromethane, sodium trichloroacetate) enhance the lipid peroxidation induced by UV light (265-300 nm) in isolated erythrocyte membranes. It was shown that the enhancement is realized with participation of excited states of membrane protein tryptophanyls, which may induce the reduction of halogen-containing compounds with formation of radicals having a high oxidative activity. Moreover, halogen-containing compounds decrease the antioxidant protection of membrane lipids owing to an increase in quantum yield of alpha-tocopherol photodestruction.
Pinchuk
S V
SV
Institute of Photobiology, Belarussian Academy of Sciences, Minsk, Belarus.
Vorobeĭ
A V
AV
D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D005609:Free Radicals; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects; D010084:Oxidation-Reduction; D014466:Ultraviolet Rays
D005609:Free Radicals; D006843:Hydrocarbons, Chlorinated