Application of acid-treated yeast cell wall (AYC) as a pharmaceutical additive. II: effects of curing on the medicine release from AYC-coated tablets.
Acid-treated yeast cell wall (AYC) was newly prepared by acidifying brewers' yeast cell wall. Core tablets containing 3% of acetaminophen (AAP) were coated with the AYC aqueous dispersion containing 5% (w/v) of AYC and 0.35% (w/v) of glycerol. The curing of AYC-coated tablets was performed at various curing periods of time and temperatures. The effects of curing on AAP release from AYC-coated tablets, the weight and thickness of the coated layer of AYC and the water sorption into the AYC-coated tablets were studied. The tensile strength and pore size distribution of the AYC cast film were measured. In the case of 60, 80, or 100 degrees C curing, AAP release from AYC-coated tablets showed a sigmoidal release profile with an initial lag time. The duration of the lag time increased with the increasing curing time and temperature, though the release rate after the lag time hardly changed. At 120 degrees C curing, the release rate after the lag time decreased with the increasing curing time and a sustained release was observed. The weight and thickness of the AYC-coated layer and the water sorption rate into AYC-coated tablets decreased with the increasing curing time and temperature. The tensile strength of the AYC cast film increased with increasing the curing temperature, particularly at 120 degrees C curing. It is considered that the water was evaporated from the AYC-coated layer and the adhesion force between AYC particles increased during curing, making the structure of the AYC-coated layer densely firm. The changes in the duration of lag time and the release rate may be due to changes in the structure of the AYC-coated layer caused by curing. These results show that it is feasible to control the lag time and the release rate of AAP from AYC-coated tablets by varying the curing time and temperature.
Yuasa
H
H
Laboratory of Medical and Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, 192-0392, Tokyo, Japan. yuasah@ps.toyaku.ac.jp
Kaneshige
J
J
Ozeki
T
T
Kasai
T
T
Eguchi
T
T
Ishiwaki
N
N
D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry; D000143:Acids; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000737:chemistry; D002473:Cell Wall / Q000737:chemistry*; D004339:Drug Compounding; D016062:Porosity; D012441:Saccharomyces cerevisiae / Q000737:chemistry*; D012995:Solubility; D013608:Tablets, Enteric-Coated / Q000737:chemistry*; D013696:Temperature; D013718:Tensile Strength; D013997:Time Factors; D014867:Water / Q000737:chemistry
D000143:Acids; D018712:Analgesics, Non-Narcotic; D013608:Tablets, Enteric-Coated; D014867:Water; D000082:Acetaminophen