title: [Pylorus preserving or classical Whipple operation in tumors. Initial clinical results of a prospective randomized study].
abstract: During the last decades, the classical Whipple resection (cWhipple) and pylorus-preserving Whipple (ppWhipple) operation have been evolved for the resection of cancer of the pancreatic head. However no definitive answer exists whether the more conservative ppWhipple indeed equalizes the short and long term results of the cWhipple procedure.
  
  
  METHODS
  Therefore we conducted a randomized prospective trial in a non-selected, consecutive patient series. All relevant data concerning patient's demographics, intraoperative and histological findings as well as postoperative mortality morbidity and follow-up after discharge were analyzed.
  
  
  RESULTS
  From 6/96 to 10/99 139 patients with suspicion of pancreatic or periampullary tumor were prospectively randomized to undergo either a cWhipple or a ppWhipple (intention to treat). Based on the inclusion and exclusion criteria, 93 of these patients were finally analyzed in the study. There were 51 cWhipple and 42 ppWhipple resections. There were no differences concerning age, sex, ASA classification, tumor type and stage, length of ICU- and in-hospital stay. However, the ppWhipple group had a significant shorter operation time. There was no difference in mortality and morbidity. The incidence of delayed gastric emptying was identical in both groups. For long-term follow-up, a total of 76 patients with histological proven pancreatic or periampullary carcinoma were analyzed. There was no difference in tumor recurrence and in long-term survival after a median follow-up of 1.5 years (0.1-3.5).
  
  
  CONCLUSIONS
  Our intermediate results demonstrate that cWhipple and ppWhipple are equally radical. However, ppWhipple may be the procedure of choice for the treatment of pancreatic and periampullary cancer.
authors.affiliation: Klinik für Viszerale und Transplantationschirurgie, Universität Bern, Inselspital.
authors.forename: C A
authors.initials: CA
authors.lastname: Seiler
authors.forename: M
authors.initials: M
authors.lastname: Wagner
authors.forename: B
authors.initials: B
authors.lastname: Schaller
authors.forename: C
authors.initials: C
authors.lastname: Sadowski
authors.forename: C
authors.initials: C
authors.lastname: Kulli
authors.forename: M W
authors.initials: MW
authors.lastname: Büchler
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000601:surgery*; D003138:Common Bile Duct Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000601:surgery*; D016577:Pancreaticoduodenectomy / Q000379:methods*; D010193:Pancreaticojejunostomy / Q000379:methods*; D015996:Survival Rate