title: Follicular adenoma with squamous metaplasia and cystic change: report of a case with fine needle aspiration cytological and histological features.
abstract: Squamous metaplasia (SM) of thyroid follicular epithelium is known to occur in a variety of non-neoplastic lesions as well in thyroid neoplasms, notably papillary carcinoma (PC). In follicular thyroid tumors, on the other hand, SM is very rare. This case describes cytological and pathological findings in a follicular adenoma (FA) that presented as a cystic lesion with extensive SM. The fine needle aspiration (FNA) cytology sample in this case yielded only necrotic material from the cystic area and squamous cells, which being mostly of immature type, were not recognised as squamous in the cytological smears. The needle missed the solid (neoplastic) component of the lesion and on the whole the cytological picture was considered to be equivocal. FA can now be added to the spectrum of thyroid lesions that can show SM. Awareness of this will enable cytopathologists to consider non-papillary lesions in the differential diagnosis of thyroid nodules that yield squamous cells.
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur.
authors.forename: G
authors.initials: G
authors.lastname: Jayaram
authors.forename: P
authors.initials: P
authors.lastname: Jayalakshmi
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001707:Biopsy, Needle; D002467:Cell Nucleus / Q000473:pathology; D003560:Cysts / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D018307:Neoplasms, Squamous Cell / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery