title: [Repetitive chemo-embolization with degradable starch microspheres (DSM) to each left and replaced right hepatic artery in a patient with multiple liver metastases of colon cancer].
abstract: In a patient with a right hepatic artery arising from the superior mesenteric artery bearing multiple liver metastases from colon cancer, hepatic arterial chemo-embolization was performed in combination with degradable starch microspheres (DSM) administered independently to the left and replaced right hepatic artery via a percutaneal approach. As the first line chemotherapy from hepatic artery with DSM 300 mg, 5-FU 500 mg and MMC 10 mg resulted in PD. DSM 300 mg, epirubicin (EPI) 50 mg, MMC 4 mg was administered with the RHA:LHA ratio of 3:1 as a second line. Four weeks later it was evaluated as NC by angiography and by tumor-marker dropped extremely. The same regimen was repeated every four weeks, and the NC status remained for 20 weeks in total. Each time, the left and replaced right hepatic artery got perfect re-perfusion and DSM enabled an effective whole liver distribution of anti-cancer drugs and repetitive administrations of them. This regimen could be an alternative choice for patients with a replaced right hepatic artery who have liver metastasis of colon cancer.
authors.affiliation: Dept. of Surgery, Suita Municipal Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Yukawa
authors.forename: J
authors.initials: J
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Shingai
authors.forename: K
authors.initials: K
authors.lastname: Takekuni
authors.forename: T
authors.initials: T
authors.lastname: Azama
authors.forename: Y
authors.initials: Y
authors.lastname: Katsumoto
authors.forename: K
authors.initials: K
authors.lastname: Nakaguchi
authors.forename: S
authors.initials: S
authors.lastname: Okajima
authors.forename: F
authors.initials: F
authors.lastname: Sue
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D003110:Colonic Neoplasms / Q000473:pathology*; D015251:Epirubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery / Q000002:abnormalities*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D017538:Mesenteric Artery, Superior / Q000002:abnormalities; D008863:Microspheres; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D013213:Starch / Q000008:administration & dosage
chemical_list: D015251:Epirubicin; D016685:Mitomycin; D013213:Starch; D005472:Fluorouracil