Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone.
Seven metabolites were isolated after anaerobic incubation of secoisolariciresinol diglucoside (1) with a human fecal suspension. They were identified as (-)-secoisolariciresinol (2), 3-demethyl-(-)-secoisolariciresinol (3), 2-(3-hydroxybenzyl)-3-(4-hydroxy-3-methoxybenzyl)butane-1,4-diol (4), didemethylsecoisolariciresinol (5), 2(3-hydroxybenzyl)-3-(3,4-dihydroxybenzyl)butane-1,4-diol (6), enterodiol (7) and enterolactone (8). Furthermore, two bacterial strains, Peptostreptococcus sp. SDG-1 and Eubacterium sp. SDG-2, responsible for the transformation of 1 to a mammalian lignan 7, were isolated from a human fecal suspension. The former transformed 2 to 3 and 5, as well as 4 to 6, and the latter transformed 5 to 6 and 7.
Wang
L Q
LQ
Institute of Natural Medicine, Toyama Mledical and Pharmaceutical University, Sugitani, Toyama, Japan.
Meselhy
M R
MR
Li
Y
Y
Qin
G W
GW
Hattori
M
M
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D002072:Butylene Glycols / Q000378:metabolism*; D003470:Culture Media; D004967:Estrogens / Q000378:metabolism*; D005051:Eubacterium / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D005960:Glucosides / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D017705:Lignans / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D010462:Peptostreptococcus / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D002072:Butylene Glycols; D003470:Culture Media; D004967:Estrogens; D005960:Glucosides; D017705:Lignans; C029498:2,3-bis(3'-hydroxybenzyl)butane-1,4-diol; D015107:4-Butyrolactone; C090142:secoisolariciresinol diglucoside; C029497:2,3-bis(3'-hydroxybenzyl)butyrolactone