Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients.
Inositol levels measured in postmortem brain of unipolar, bipolar and schizophrenic patients, suicide victims and normal controls showed no difference in scyllo-inositol levels in frontal or occipital cortex between any of the groups. We could not replicate previous reports of low myo-inositol levels in the frontal cortex of unipolar, bipolar and schizophrenic patients and suicide victims. There was no correlation between myo-inositol levels and estimated chlorpromazine equivalents in neuroleptic-treated subjects, and no effect of chronic haloperidol treatment on rat brain myo-inositol levels.
Shapiro
J
J
Stanley Center for Bipolar Research, Ben-Gurion University of the Negev, Beersheva, Israel.
Belmaker
R H
RH
Biegon
A
A
Seker
A
A
Agam
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001714:Bipolar Disorder / Q000378:metabolism* / Q000473:pathology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000378:metabolism / Q000473:pathology; D051381:Rats; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology; D013405:Suicide
D014150:Antipsychotic Agents; C009217:scyllitol; D007294:Inositol; D006220:Haloperidol