title: [Treatment of advanced Parkinson's disease].
abstract: After the advent of levodopa, treatment of Parkinson's disease has changed and the activity of daily life of patients has been remarkably improved; whereas, many patients experience various problems such as wearing-off, dyskinesia, dystonia, neuropsychiatric problems, and dysautonomia. Especially, wearing-off and dyskinesia emerge with the change of absorptional pattern of levodopa and could be solved by regulating the timing and the dose of it. Recently, some new drugs for Parkinson's disease have been available and we physician have a wide choice of them. It is important to make a careful choice of and manipulate of doses of drugs after understanding daily life of each patient enough.
authors.affiliation: Department of Neurology, Graduate School of Medicine, University of Tokyo.
authors.forename: Y
authors.initials: Y
authors.lastname: Momose
authors.forename: M
authors.initials: M
authors.lastname: Murata
authors.forename: I
authors.initials: I
authors.lastname: Kanazawa
mesh_terms: D000978:Antiparkinson Agents / Q000008:administration & dosage; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced; D015259:Dopamine Agents / Q000008:administration & dosage; D018491:Dopamine Agonists / Q000008:administration & dosage; D004409:Dyskinesia, Drug-Induced; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects; D010300:Parkinson Disease / Q000188:drug therapy*; D011605:Psychoses, Substance-Induced; D012720:Severity of Illness Index
chemical_list: D000978:Antiparkinson Agents; D015259:Dopamine Agents; D018491:Dopamine Agonists; D007980:Levodopa