[Prognostic value of serum MMP-2 level in uterine cancer affected women].
OBJECTIVE
Matrix metalloproteinase-2 (MMP-2) which can degrade type IV collagen is implicated in cancer invasion and metastasis. The aim of the study was to evaluate the serum MMP-2 level in patients with endometrial carcinoma (EC) and to compare the level with histological grade G1 to G3 in relation to clinical staging I degree-IV degrees as well as myometrial invasion (M. < 1/2, M. > 1/2).


METHODS
The study group consisted of 30 patients with EC. MMP-2 serum levels were measured with specific one-step sandwich enzyme immunoassay (Amersham Life Science). Statistical analysis was performed by Mann-Whitney test and p value < 0.05 was considered as statistically significant.


RESULTS
The statistically elevated enzyme level was observed in patients presenting II degrees-IV degrees clinical stage of EC in comparison to women with I degree stage of this carcinoma. There were no significant correlations between MMP-2 serum levels and grades of histological differentiation as well as depth of myometrium invasion.


CONCLUSIONS
MMP-2 serum level is statistically higher in clinically advanced stages of EC. This enzyme seems to be useful in monitoring of therapeutical efficacy or screening for the recurrences of the disease.
Adamiak
A
A
Kliniki Ginekologii Operacyjnej II Katedry Połoznictwa i Chorób Kobiecych Akademii Medycznej w Lublinie.
Postawski
K
K
Semczuk
A
A
Rechberger
T
T
Jakowicki
J A
JA
D000328:Adult; D002277:Carcinoma / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D009215:Myometrium / Q000201:enzymology; D009367:Neoplasm Staging; D011379:Prognosis; D014594:Uterine Neoplasms / Q000097:blood / Q000201:enzymology* / Q000473:pathology
D020778:Matrix Metalloproteinase 2