Triazine-based condensing reagents.
The synthesis, properties, and application of condensing reagents derived from 1,3,5-triazines are described. The mechanism of activation of carboxylic function, structure of reactive intermediates, and mechanism of acylation of nucleophiles are presented. The synthetic versatility of mono- and bifunctional reagents for syntheses in solution, triazine-based immobilized reagents, chiral triazines for enantiodifferentiating syntheses, are discussed. The scope and limitation of the synthetic utility of triazine reagents in the preparation of heterocyclic compounds, amides, esters, oligopeptides-including large-scale syntheses and use in the combinatorial chemistry-is demonstrated.
Kamiński
Z J
ZJ
Institute of Organic Chemistry, Technical University of Lódz, 90-924 Lódz, Poland. kaminsz@ck-sg.p.lodz.pl
D020650:Combinatorial Chemistry Techniques; D010455:Peptides / Q000138:chemical synthesis; D011108:Polymers / Q000138:chemical synthesis; D011134:Polysaccharides / Q000138:chemical synthesis; D013237:Stereoisomerism; D014227:Triazines / Q000737:chemistry*
D010455:Peptides; D011108:Polymers; D011134:Polysaccharides; D014227:Triazines