title: Effect of pregnancy on chronic hepatitis C: a case-control study.
abstract: There is evidence of deterioration of hepatitis C after pregnancy. To investigate potential histological changes, we compared liver biopsy samples taken before and after delivery from 12 women positive for hepatitis C virus (HCV) and 12 nonpregnant HCV-positive women. Semiquantitative histopathological measurements showed greater deterioration in cases than in controls (necroinflammatory score deterioration 83.3% vs 25.0%; fibrosis score 41.6% vs 8.3%). This case-control study suggests that pregnancy may worsen HCV-related histopathological injury.
authors.forename: H
authors.initials: H
authors.lastname: Fontaine
authors.forename: B
authors.initials: B
authors.lastname: Nalpas
authors.forename: F
authors.initials: F
authors.lastname: Carnot
authors.forename: C
authors.initials: C
authors.lastname: Bréchot
authors.forename: S
authors.initials: S
authors.lastname: Pol
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D019698:Hepatitis C, Chronic / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000473:pathology*; D000637:Transaminases / Q000378:metabolism
chemical_list: D000637:Transaminases