title: Synthesis of (1-->4)-linked 2-deoxy-2-fluoroglucose oligomers. 1.
abstract: [reaction: see text] Thioglycosides of natural monosaccharides are readily converted into their corresponding chlorides by diphenylchlorosulfonium chloride. This reagent can likewise effect the conversion of the more stable 4-chlorophenylthio 2-deoxy-2-fluoroglucose derivatives into chloride glycosyl donors. On the basis of this activation strategy, it was possible to assemble unnatural oligosaccharides composed of 2-fluorodeoxy sugars.
authors.affiliation: Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8.
authors.forename: S
authors.initials: S
authors.lastname: Sugiyama
authors.forename: W
authors.initials: W
authors.lastname: Haque
authors.forename: J
authors.initials: J
authors.lastname: Diakur
mesh_terms: D002236:Carbohydrate Conformation; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000737:chemistry*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D009844:Oligosaccharides; D003847:Deoxyglucose