Sequential evaluation of left ventricular myocardial performance in children after anthracycline therapy.
This study prospectively assessed subclinical cardiotoxicity in patients undergoing chemotherapy by using the Tei index combining systolic and diastolic time intervals. A significant difference in the Tei index was observed between patients who received a low dose and those who received a moderate to high dose of anthracycline antibiotic drugs. The Tei index is a sensitive, accurate, and easy approach for detecting subclinical anthracycline cardiotoxicity.
Ishii
M
M
Department of Pediatrics and the Cardiovascular Research Institute, Kurume University School of Medicine, Japan. masaishi@med.kurume-u.ac.jp
Tsutsumi
T
T
Himeno
W
W
Eto
G
G
Furui
J
J
Hashino
K
K
Sugahara
Y
Y
Muta
H
H
Akagi
T
T
Ando
A
A
Eguchi
H
H
Kato
H
H
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001783:Blood Flow Velocity / Q000187:drug effects; D002648:Child; D015150:Echocardiography, Doppler; D006801:Humans; D008479:Mediastinal Neoplasms / Q000188:drug therapy*; D009200:Myocardial Contraction / Q000187:drug effects; D015588:Observer Variation; D011379:Prognosis; D011446:Prospective Studies; D013318:Stroke Volume / Q000187:drug effects; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000503:physiopathology*
D000903:Antibiotics, Antineoplastic