Malignant lymphoma in nasal cavity and paranasal sinuses of a dog.
A case of a canine large cell type T-cell lymphoma, with features of high-grade malignancy is described. The tumour was found confined in the nasal cavity and the paranasal sinuses of a crossbred German Shepherd dog. Histological examination revealed the features of a highly malignant large cell lymphoma. Ultrastructurally, the lymphoid tumour cells bore cytoplasmic protrusions that interdigitated tightly. From a panel of tumour markers used, the neoplastic cells were stained only for vimentin. Immunophenotyping of the tumour cells by means of CD3, CD79, kappa-light chains and lambda-light chains detection was undertaken. The tumour stained only for CD3 and was classified as T-cell lymphoma.
Kaldrymidou
E
E
Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece.
Papaioannou
N
N
Poutahidis
T
T
Karayannopoulou
M
M
Gruys
E
E
Toliou
T
T
Tsangaris
T
T
D000818:Animals; D000911:Antibodies, Monoclonal; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology / Q000662:veterinary*; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000662:veterinary; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography
D000911:Antibodies, Monoclonal