Understanding the apical surface markers of uterine receptivity: pinopods-or uterodomes?
The plasma membrane of uterine epithelial cells is very sensitive to ovarian hormones and protrusions of the apical portion of this membrane have been used as indicators of endocrine status and preparation for implantation in the human uterus in particular. Protrusions of the apical plasma membrane were first identified in rats and mice where their established pinocytotic function gave rise to the name 'pinopod'. In humans and many other animals however, little evidence of the functional nature of such protrusions is available but what is available suggests that human 'pinopods' (useful though they are as indicators of endocrine status) might be more similar morphologically to other, larger, membrane protrusions, or apical domes, which have been shown not to be pinocytotic. Hence, I propose that these latter protrusions, including those in the human uterus, should be referred to by a term which does not imply a particular function and have settled on the name 'uterodome'.
Murphy
C R
CR
Department of Anatomy and Histology, F13, The University of Sydney, NSW 2006, Australia. histology@anatomy.usyd.edu.au.
D000818:Animals; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure*; D010064:Embryo Implantation; D004847:Epithelial Cells / Q000648:ultrastructure; D005260:Female; D006728:Hormones / Q000502:physiology; D006801:Humans; D010873:Pinocytosis; D009626:Terminology as Topic; D014599:Uterus / Q000502:physiology* / Q000648:ultrastructure*
D006728:Hormones