title: Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica.
abstract: A highly potent anti-MRSA sesquiterpenoid has been isolated from Ulmus davidiana var. japonica, which has been traditionally used to treat infectious diseases in Korea. This naturally occurring antibiotic was identified as mansonone F (1). This compound has been found to be highly active specifically against MRSA and showed an MIC range of 0.39-3.13 microg/ml which is comparable to that of vancomycin.
authors.affiliation: College of Pharmacy, Seoul National University, Kwanak-Gu, Korea.
authors.forename: D Y
authors.initials: DY
authors.lastname: Shin
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Min
authors.forename: S S
authors.initials: SS
authors.lastname: Hyun
authors.forename: S A
authors.initials: SA
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Huh
authors.forename: E C
authors.initials: EC
authors.lastname: Choi
authors.forename: Y H
authors.initials: YH
authors.lastname: Choi
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Choi
authors.forename: W B
authors.initials: WB
authors.lastname: Kim
authors.forename: Y G
authors.initials: YG
authors.lastname: Suh
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D007723:Korea; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D019441:Plant Epidermis / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D011809:Quinones; D012717:Sesquiterpenes