title: Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis.
abstract: Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important (population attributable fraction=69%) influence on susceptibility to such episodes.
authors.forename: N
authors.initials: N
authors.lastname: Coyle
authors.forename: I
authors.initials: I
authors.lastname: Jones
authors.forename: E
authors.initials: E
authors.lastname: Robertson
authors.forename: C
authors.initials: C
authors.lastname: Lendon
authors.forename: N
authors.initials: N
authors.lastname: Craddock
mesh_terms: D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011618:Psychotic Disorders / Q000235:genetics; D011644:Puerperal Disorders / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins; D020080:Tandem Repeat Sequences / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA