title: Analysis of the distribution of HLA-A alleles in populations from five continents.
abstract: The variation and frequency of HLA-A genotypes were established by PCR-SSOP typing in diverse geographically distributed populations: Brazilian, Colombian Kogui, Cuban, Mexican, Omani, Singapore Chinese, and South African Zulu. HLA-A allelic families with only one allele were identified for HLA-A*01, -A*23, -A*25, -A*31, -A*32, -A*36, -A*43, -A*69, -A*80; and with two alleles for HLA-A*03, -A*11, -A*26, -A*29, -A*33, -A*34, and -A*66. Greater variation was detected for HLA-A*02, -A*24, and -A*68 allele families. Colombian Kogui and Mexican Seris showed the least diversity with respect to HLA-A alleles, albeit with small numbers tested, with only four and five HLA-A alleles identified, respectively. It would appear by their presence in all populations studied, either rural or indigenous, that certain alleles are very important in pathogen peptide presentation.
authors.affiliation: Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland, UK.
authors.forename: D
authors.initials: D
authors.lastname: Middleton
authors.forename: F
authors.initials: F
authors.lastname: Williams
authors.forename: A
authors.initials: A
authors.lastname: Meenagh
authors.forename: A S
authors.initials: AS
authors.lastname: Daar
authors.forename: C
authors.initials: C
authors.lastname: Gorodezky
authors.forename: M
authors.initials: M
authors.lastname: Hammond
authors.forename: E
authors.initials: E
authors.lastname: Nascimento
authors.forename: I
authors.initials: I
authors.lastname: Briceno
authors.forename: M P
authors.initials: MP
authors.lastname: Perez
mesh_terms: D000349:Africa; D000483:Alleles; D001938:Brazil; D002681:China; D005828:Genetics, Population; D005838:Genotype; D015234:HLA-A Antigens / Q000145:classification* / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007198:Indians, North American; D008800:Mexico; D009850:Oman; D016133:Polymerase Chain Reaction / Q000379:methods*
chemical_list: D015234:HLA-A Antigens