title: ADP receptors in platelet activation and aggregation.
abstract: ADP plays a central role in platelet aggregation. Activation of platelets via ADP proceeds via three membrane receptor proteins, two of which are coupled to a G protein and the third one constituting an ion channel mediating rapid Ca2+-influx. Via Ca2+-mobilization, the Gq-coupled P2Y1 receptor acts in concert with the Gi-coupled P2TAC receptor, which functions by lowering intracellular cAMP levels. The importance of Ca2+-influx via the P2X1 ion channel remains to be elucidated.
authors.affiliation: Center for Molecular and Vascular Biology, University of Leuven, Belgium. Marc.Hoylaerts@med.kuleuven.ac.be
authors.forename: M F
authors.initials: MF
authors.lastname: Hoylaerts
authors.forename: C
authors.initials: C
authors.lastname: Oury
authors.forename: E
authors.initials: E
authors.lastname: Toth-Zsamboki
authors.forename: J
authors.initials: J
authors.lastname: Vermylen
mesh_terms: D000818:Animals; D006801:Humans; D015539:Platelet Activation / Q000502:physiology*; D010974:Platelet Aggregation / Q000502:physiology*; D018048:Receptors, Purinergic P2 / Q000097:blood*
chemical_list: D018048:Receptors, Purinergic P2