Placental abnormalities associated with human immunodeficiency virus type 1 infection and perinatal transmission in Bangkok, Thailand.
The effects of human immunodeficiency virus (HIV) type 1 on the placenta and the role of the placenta in mother-to-child HIV-1 transmission are not well understood. Placentas from 78 HIV-infected and 158 HIV-uninfected women were examined as part of a prospective perinatal HIV transmission study in Bangkok. HIV-infected women were more likely than HIV-uninfected women to have chorioamnionitis (odds ratio [OR], 2.1; P=.03), placental membrane inflammation (PMI; OR, 2. 7; P=.02), and deciduitis (OR, 2.3; P=.03) and less likely to have villitis (OR, 0.3; P=.02). However, among HIV-infected women, fewer women who transmitted infection to their child had chorioamnionitis (relative risk [RR], 0.2; P=.03), funisitis (RR, 0.4; P=.1), or PMI (RR undefined; P=.03). These findings suggest that, in this population, HIV-infected women are at increased risk for placental membrane inflammatory lesions, but that placental inflammatory lesions are not associated with increased perinatal HIV transmission.
Schwartz
D A
DA
Departments of Pathology and Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Sungkarat
S
S
Shaffer
N
N
Laosakkitiboran
J
J
Supapol
W
W
Charoenpanich
P
P
Chuangsuwanich
T
T
Mastro
T D
TD
D000293:Adolescent; D000328:Adult; D002821:Chorioamnionitis / Q000473:pathology; D002824:Chorionic Villi / Q000473:pathology; D015331:Cohort Studies; D003656:Decidua / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000473:pathology / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology*; D011446:Prospective Studies; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D014470:Umbilical Cord / Q000473:pathology