title: PAcM-AN: poly (N-acryloylmorpholine)-conjugated antisense oligonucleotides.
abstract: A new amphiphilic, high-molecular weight poly (N-acryloylmorpholine) (PAcM) polymer has been used to be linked to oligonucleotide chains through a liquid-phase stepwise synthesis. This new conjugate has been investigated for its melting property, nuclease stability and capacity to elicit RNase H activity. Its antisense activity against an HIV-1 target has been also evaluated.
authors.affiliation: Dept. of Chemical Sciences, University of Trieste, Italy.
authors.forename: G M
authors.initials: GM
authors.lastname: Bonora
authors.forename: A M
authors.initials: AM
authors.lastname: De Franco
authors.forename: R
authors.initials: R
authors.lastname: Rossin
authors.forename: F M
authors.initials: FM
authors.lastname: Veronese
authors.forename: P
authors.initials: P
authors.lastname: Ferruti
authors.forename: O
authors.initials: O
authors.lastname: Plyasunova
authors.forename: P E
authors.initials: PE
authors.lastname: Vorobjev
authors.forename: D V
authors.initials: DV
authors.lastname: Pyshnyi
authors.forename: N I
authors.initials: NI
authors.lastname: Komarova
authors.forename: V F
authors.initials: VF
authors.lastname: Zarytova
mesh_terms: D005786:Gene Expression Regulation / Q000187:drug effects; D005960:Glucosides; D007288:Inosine / Q000031:analogs & derivatives; D015394:Molecular Structure; D008970:Molecular Weight; D009025:Morpholines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009691:Nucleic Acid Denaturation; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry; D016914:Ribonuclease H / Q000378:metabolism*; D012995:Solubility
chemical_list: C421447:1-glucopyranosylinosine-5',6'-diphosphate; D005960:Glucosides; D009025:Morpholines; D016376:Oligonucleotides, Antisense; D011092:Polyethylene Glycols; D007288:Inosine; C028210:monomethoxypolyethylene glycol; D016914:Ribonuclease H