title: A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens.
abstract: A large number of recombinant of viral and bacterial systems have been engineered as vectors to express foreign genes for vaccination and/or gene therapy. A common problem is the immune response to the vector itself. The presence of anti-vector immune responses may preclude sufficient 'priming' or immunogenicity if pre-existing immune responses are present, or they may impair optimal 'boosting' upon repeated immunization or delivery with the same vector. To circumvent this problem we developed a strategy using different chimeric vectors which share only the expression of common specific antigens desired for immunization. This approach not only has the advantage of avoiding increased anti-vector responses, but allows the use of combinations of vectors which could subsequently present the same or related antigen differently to the immune system as well as at alternative sites to induce the optimal type of immunity against the pathogen of interest.
authors.affiliation: Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands. heeney@bprc.nl
authors.forename: J L
authors.initials: JL
authors.lastname: Heeney
authors.forename: G
authors.initials: G
authors.lastname: Koopman
authors.forename: B
authors.initials: B
authors.lastname: Rosenwirth
authors.forename: W
authors.initials: W
authors.lastname: Bogers
authors.forename: J
authors.initials: J
authors.lastname: van Dijk
authors.forename: I
authors.initials: I
authors.lastname: Nieuwenhuis
authors.forename: H
authors.initials: H
authors.lastname: Niphuis
authors.forename: P
authors.initials: P
authors.lastname: ten Haaft
authors.forename: T
authors.initials: T
authors.lastname: Hanke
authors.forename: G
authors.initials: G
authors.lastname: Rhodes
authors.forename: P
authors.initials: P
authors.lastname: Berglund
authors.forename: A
authors.initials: A
authors.lastname: Burny
authors.forename: F
authors.initials: F
authors.lastname: Bex
authors.forename: G
authors.initials: G
authors.lastname: Sutter
authors.forename: P
authors.initials: P
authors.lastname: Liljeström
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D002678:Chimera; D015752:Genes, env; D015750:Genes, gag; D015754:Genes, nef; D015751:Genes, pol; D015757:Genes, rev; D015756:Genes, tat; D008253:Macaca mulatta; D018449:SAIDS Vaccines / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D018449:SAIDS Vaccines; D014614:Vaccines, Synthetic