title: Ectopic submandibular thyroid tissue with a coexisting active and normally located thyroid gland: case report and review of literature.
abstract: Ectopic thyroid tissue in the submandibular space with the thyroid gland in its normal location is an extremely rare phenomenon. We present a case of a 75-year-old woman who had painless swelling in the left submandibular space and was referred to our hospital with the suspicion of having a malignant tumor originating from the submandibular gland. Histologic examination showed normal follicular thyroid tissue without any sign of malignancy. In general there are 3 explanations for the presence of ectopic thyroid tissue found in the submandibular region: (1) displacement during the course of embryonal development, (2) spread of tissue during surgery on a normally located thyroid gland, and (3) metastasis of a highly differentiated papillary thyroid carcinoma. We reviewed the literature with respect to the embryological background and the clinical management of such cases.
authors.affiliation: University Hospital Carl Gustav Carus, Technical University of Dresden, Germany. kufeller@rcs.urz.tu-dresden.de
authors.forename: K U
authors.initials: KU
authors.lastname: Feller
authors.forename: A
authors.initials: A
authors.lastname: Mavros
authors.forename: H J
authors.initials: HJ
authors.lastname: Gaertner
mesh_terms: D000368:Aged; D002828:Choristoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m; D013364:Submandibular Gland Diseases / Q000473:pathology* / Q000601:surgery; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000502:physiology*; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m