Delta 32 deletion of CCR5 gene and association with asthma or atopy.
The CCR5-delta32 deletion polymorphism (CCR5-delta32) was investigated for linkage and association to asthma and atopy using two panels of nuclear families containing 1284 individuals. No statistically significant linkage to asthma/wheeze or atopy was observed in either of the two panels of families. Multiallelic transmission disequilibrium tests (TDT) of the combined data found no significant association for atopy (52 independent alleles transmitted, 51 non-transmitted) or asthma/wheeze (39 transmitted, 44 non-transmitted). Although functional evidence might suggest that CCR5 is a good candidate gene for atopic asthma, this study provides no genetic evidence from CCR5-delta32 polymorphism to support this hypothesis.
Mitchell
T J
TJ
Walley
A J
AJ
Pease
J E
JE
Venables
P J
PJ
Wiltshire
S
S
Williams
T J
TJ
Cookson
W O
WO
D000483:Alleles; D001249:Asthma / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005190:Family; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D017384:Sequence Deletion; D006113:United Kingdom; D014904:Western Australia
D019713:Receptors, CCR5; D004247:DNA