Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides.
Nine bis-acridine derivatives have been synthesized in search of structures with antiviral properties. Synthesis of target compounds was provided by a standard peptide-like coupling procedure using aliphatic diamines and protected amino acids following protective group removing and acridinylation by means of 9-methoxyacridine. Two out of nine compounds tested demonstrate high protective activity of Vero cells against HSV infection. Antiviral activity was observed only for compounds containing a pentamethylene fragment as a linker. The alanyl-containing derivative was less active than those containing valyl- and phenylalanyl. Most of synthesized compounds were less toxic than N,N'-bis-(acridinyl) hexamethylenediamine.
Lyakhov
S A
SA
A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine.
Suveyzdis
Y I
YI
Litvinova
L A
LA
Andronati
S A
SA
Rybalko
S L
SL
Dyadyun
S T
ST
D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D007364:Intercalating Agents / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D018139:Simplexvirus / Q000187:drug effects; D014709:Vero Cells
D000166:Acridines; D000998:Antiviral Agents; D007364:Intercalating Agents