title: The utility of polysporin ointment in the eradication of methicillin-resistant Staphylococcus aureus colonization: a pilot study.
abstract: We evaluated the efficacy of an ointment containing bacitracin, polymyxin B, and gramicidin for the eradication of colonization by methicillin-resistant Staphylococcus aureus in 11 medical patients, 10 (91%) of whom had previously failed a 1-week course of topical mupirocin. Mupirocin resistance was documented in 5 (45%) of 11 patients. Successful decolonization was achieved in 9 (82%) of 11 patients (based on 2 months of follow-up).
authors.affiliation: Department of Medicine, Toronto General and Toronto Western Hospitals, University of Toronto, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Fung
authors.forename: S
authors.initials: S
authors.lastname: O'Grady
authors.forename: C
authors.initials: C
authors.lastname: Kennedy
authors.forename: H
authors.initials: H
authors.lastname: Dedier
authors.forename: I
authors.initials: I
authors.lastname: Campbell
authors.forename: J
authors.initials: J
authors.lastname: Conly
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001414:Bacitracin / Q000494:pharmacology*; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D005260:Female; D006096:Gramicidin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D016712:Mupirocin / Q000494:pharmacology; D009824:Ointments; D010865:Pilot Projects; D011112:Polymyxin B / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009824:Ointments; C420142:polysporin ointment; D001414:Bacitracin; D006096:Gramicidin; D016712:Mupirocin; D011112:Polymyxin B