title: Effects of acute ingestion of salbutamol during submaximal exercise.
abstract: To assess the eventual effects of acute oral salbutamol intake on performance and metabolism during submaximal exercise, nine healthy volunteers completed two cycling trials at a power corresponding to 80-85% VO2max, after either placebo (Pla) or salbutamol (Sal, 6 mg) treatment, according to a double-blind randomized protocol. Blood samples were collected both at rest and during exercise (5 min-, 10 min-, 15 min-exhaustion) for C-peptide, FFA, lactate and blood glucose measurements. Cycling performance was significantly improved in the Sal vs. Pla trials (p < 0.05). After Sal intake, resting C-peptide, lactate, FFA and blood glucose values were higher whereas exercise lactate and free fatty acid concentrations were greater during and at the conclusion of the exercise period (p < 0.05). These results suggest that acute salbutamol ingestion improved performance during submaximal exercise probably through an enhancement of the overall contribution to energy production from both aerobic and anaerobic metabolisms.
authors.affiliation: Laboratoire National de Dépistage du Dopage, Chatenay-Malabry, France. katia.collomp@staps.u-psud.fr
authors.forename: K
authors.initials: K
authors.lastname: Collomp
authors.forename: R
authors.initials: R
authors.lastname: Candau
authors.forename: R
authors.initials: R
authors.lastname: Collomp
authors.forename: J
authors.initials: J
authors.lastname: Carra
authors.forename: F
authors.initials: F
authors.lastname: Lasne
authors.forename: C
authors.initials: C
authors.lastname: Préfaut
authors.forename: J
authors.initials: J
authors.lastname: De Ceaurriz
mesh_terms: D000284:Administration, Oral; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage*; D001642:Bicycling; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D004311:Double-Blind Method; D004734:Energy Metabolism / Q000187:drug effects; D017079:Exercise Tolerance / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male
chemical_list: D000318:Adrenergic beta-Agonists; D001786:Blood Glucose; D002096:C-Peptide; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D000420:Albuterol