title: Aqueous dispersion behavior of drug particles by addition of surfactant and polymer.
abstract: The effect of surfactant and polymer on dispersion stability of aqueous suspensions of 5-(3-ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione (CT112) was investigated by measuring the adsorbed amount of surfactant and polymer, zeta potential, particle size, and sedimentation rate of CT112. The addition of celluloses rather than sodium dodecyl sulfate (SDS) provided a high stable suspension of CT112. In addition, mixed systems of celluloses and SDS enhanced CT112 dispersion more effectively. The mechanism of dispersion stability of CT112 by addition of SDS and celluloses is discussed.
authors.affiliation: Chemical Development, International Division, Senju Pharmaceutical Co. Ltd, 2-5-8 Hiranomachi, Chuo-ku, 541-0046, Osaka, Japan
authors.initials: H
authors.lastname: Terayama
authors.initials: K
authors.lastname: Okumura
authors.initials: K
authors.lastname: Sakai
authors.initials: K
authors.lastname: Torigoe
authors.initials: K
authors.lastname: Esumi