title: The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis.
abstract: BACKGROUND
  Many patients with psoriasis are known to suffer from itch. However, the data available regarding itch and its characteristics in psoriasis are sparse.
  
  
  OBJECTIVE
  To examine the prevalence of pruritus and various related clinical characteristics in 101 patients with extensive psoriasis.
  
  
  METHODS
  A structured questionnaire was used.
  
  
  RESULTS
  Generalized pruritus was a feature of psoriasis in 84% of the patients. In 77% of these it appeared on a daily basis. It involved all areas of the body, had prolonged duration and appeared mainly in the evening and at night. The pruritus significantly affected quality of life. Important daily factors that were found to exacerbate the itch were ambient heat (81%), skin dryness (80%), sweating (65%) and stress (55%). Important factors that were found to ameliorate itch were sleep (57%) and cold showers (55%). The pruritus was found to be unresponsive to most available antipruritics, including phototherapy. Itch intensity as reflected by a visual analogue scale did not correlate with Psoriasis Area and Severity Index scores; however, a highly significant correlation was obtained between the affective descriptors and itch intensity in the worst itch states (r = 0.6, P < 0.001).
  
  
  CONCLUSIONS
  Pruritus is a common feature of psoriasis and affects quality of life.
authors.affiliation: National Skin Centre, 1 Mandalay Road, Singapore 308205Clinical Trials and Epidemiology Research Unit, National Medical Research Council, Ministry of Health, Singapore. gil@nsc.gov.sg
authors.forename: G
authors.initials: G
authors.lastname: Yosipovitch
authors.forename: A
authors.initials: A
authors.lastname: Goon
authors.forename: J
authors.initials: J
authors.lastname: Wee
authors.forename: Y H
authors.initials: YH
authors.lastname: Chan
authors.forename: C L
authors.initials: CL
authors.lastname: Goh
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D000982:Antipruritics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000188:drug therapy / Q000209:etiology*; D011565:Psoriasis / Q000150:complications*; D011788:Quality of Life; D012307:Risk Factors; D012677:Sensation; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D017211:Treatment Failure
chemical_list: D000982:Antipruritics