title: Sildenafil causes a dose- and time-dependent downregulation of phosphodiesterase type 6 expression in the rat retina.
authors.forename: R
authors.initials: R
authors.lastname: Heywood
authors.forename: I H
authors.initials: IH
authors.lastname: Osterloh
authors.forename: S C
authors.initials: SC
authors.lastname: Phillips
mesh_terms: D000818:Animals; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6; D015536:Down-Regulation / Q000187:drug effects*; D021902:Enterobacter aerogenes / Q000378:metabolism; D066298:In Vitro Techniques; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases / Q000096:biosynthesis*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D051381:Rats; D000068677:Sildenafil Citrate; D013450:Sulfones
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D010727:Phosphoric Diester Hydrolases; D054707:Cyclic Nucleotide Phosphodiesterases, Type 6