Surgical repair of full-thickness idiopathic macular holes associated with significant macular drusen.
OBJECTIVE
To evaluate the visual and anatomic results of surgically repaired macular holes in eyes with intermediate or large-sized macular drusen.


METHODS
Retrospective noncomparative case series.


METHODS
Thirty-four eyes of 32 patients undergoing macular hole surgery with preoperative intermediate or large-sized macular drusen as defined by the Age-Related Eye Disease Study (AREDS).


METHODS
Pars plana vitrectomy for standard macular hole repair performed by multiple surgeons.


METHODS
Visual acuity, anatomic hole closure.


RESULTS
Initial hole closure failed in 8 eyes (24%) overall, 5 of 28 eyes (18%) with AREDS category 2 drusen and 3 of 6 eyes (50%) with category 3 drusen (P = 0.1263). Final macular hole closure was seen in 93% of category 2 and 67% of category 3 eyes (P = 0.1347). Mean final visual acuity was 20/60 overall, 20/60 for category 2, and 20/50 for category 3 eyes.


CONCLUSIONS
A trend of reduced initial macular hole closure was seen in eyes with significant macular drusen. Reoperation improved closure rates. If closure was accomplished, visual outcomes were excellent.
Berinstein
D M
DM
Associated Retinal Consultants, PC, Department of Ophthalmology, Beaumont Eye Institute, Royal Oak, Michigan, USA.
Hassan
T S
TS
Williams
G A
GA
Margherio
R R
RR
Ruby
A J
AJ
Garretson
B R
BR
D000368:Aged; D005260:Female; D006801:Humans; D008266:Macula Lutea; D008297:Male; D015593:Retinal Drusen / Q000150:complications* / Q000503:physiopathology; D012167:Retinal Perforations / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy