Substituted guanidines: introducing diversity in combinatorial chemistry.
The guanidine moiety is an important motif present in many biologically active compounds. Fully substituted guanidines are of key importance for the development of bioactive molecules. The present paper reports on an efficient procedure for the direct solid-phase conversion of amines to fully substituted guanidines under very mild conditions.
del Fresno
M
M
Departament de Química Orgànica, Universitat de Barcelona, 08028 Barcelona, Spain.
El-Faham
A
A
Carpino
L A
LA
Royo
M
M
Albericio
F
F
D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D006146:Guanidines; D007202:Indicators and Reagents