Ethnic differences in the impact of advanced maternal age on birth prevalence of Down syndrome.
OBJECTIVE
This study explored whether ethnic differences in the impact of advanced maternal age on the risk of Down syndrome might reflect differences in use of prenatal diagnostic technologies.


METHODS
Maternal age-specific odds of Down syndrome and amniocentesis use were compared among African Americans, Mexican Americans, and non-Hispanic Whites via birth data for the years 1989 to 1991.


RESULTS
The odds ratio and population attributable risk of Down syndrome due to maternal age of 35 years or older were highest for Mexican Americans, intermediate for African Americans, and lowest for non-Hispanic Whites.


CONCLUSIONS
Advanced maternal age has a greater impact on the risk of Down syndrome for African American and, particularly, Mexican American women than for non-Hispanic White women. This difference in impact might reflect lower availability or use of prenatal diagnostic technologies.
Khoshnood
B
B
Department of Pediatrics, University of Chicago, Ill., USA.
Pryde
P
P
Wall
S
S
Singh
J
J
Mittendorf
R
R
Lee
K S
KS
D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data*; D017677:Age Distribution; D000649:Amniocentesis / Q000706:statistics & numerical data; D004314:Down Syndrome / Q000175:diagnosis* / Q000208:ethnology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008423:Maternal Age; D017058:Mexican Americans / Q000706:statistics & numerical data*; D008875:Middle Aged; D016017:Odds Ratio; D011159:Population Surveillance; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis / Q000379:methods / Q000706:statistics & numerical data*; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data*