title: Lack of association between CD28/CTLA-4 gene polymorphisms and atopic asthma in the Japanese population.
abstract: Atopic asthma occurs in genetically susceptible individuals in the presence of environmental factors. Recently, the costimulation signal from CD80-CD86 to CD28/CTLA-4 has been suggested to play an important role in the development of atopic asthma. In the present study, we analyzed three polymorphic regions within the CTLA-4 gene, an A/G substitution in exon 1 position 49, a C/T base exchange in the promoter position -318 and an (AT)n repeat polymorphism in the 3'-untranslated region of exon 4, and a CD28 gene polymorphism with a T/C substitution in intron 3 position +17 in 120 patients with atopic asthma and 200 normal controls. The polymorphism frequencies of CTLA-4/CD28 genes in patients did not differ from those in normal controls. Thus, the present study was unable to reveal any association between CTLA-4/CD28 gene polymorphisms and atopic asthma in the Japanese population.
authors.affiliation: Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. nakaof@pediatr.med.kyushu-u.ac.jp
authors.forename: F
authors.initials: F
authors.lastname: Nakao
authors.forename: K
authors.initials: K
authors.lastname: Ihara
authors.forename: S
authors.initials: S
authors.lastname: Ahmed
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Kusuhara
authors.forename: A
authors.initials: A
authors.lastname: Takabayashi
authors.forename: S
authors.initials: S
authors.lastname: Nishima
authors.forename: T
authors.initials: T
authors.lastname: Hara
mesh_terms: D000069594:Abatacept; D000328:Adult; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D044466:Asian People; D001249:Asthma / Q000235:genetics* / Q000276:immunology*; D018106:CD28 Antigens / Q000235:genetics*; D060908:CTLA-4 Antigen; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D018796:Immunoconjugates; D011110:Polymorphism, Genetic
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D018106:CD28 Antigens; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D018796:Immunoconjugates; D000069594:Abatacept