title: Isaacs' syndrome successfully treated by immunoadsorption plasmapheresis.
abstract: We report a 70-year-old woman with Isaacs' syndrome (acquired neuromyotonia) who showed a marked improvement after immunoadsorption plasmapheresis (IAP). She developed hyperhidrosis in her teens, and slowly progressive symptoms of neuromyotonia for over 50 years. An in vitro investigation of her serum with patch-clamp technique suggested the presence of antibodies against potassium channels. She was treated with IAP, which brought disappearance of her symptoms. Though the symptoms started to recur in 3 weeks, moderate improvement has been maintained by immunosuppressive drug treatment.
authors.affiliation: Department of Neurology, Osaka University Graduate School of Medicine, Suita, Japan. yuji@neurol.med.osaka-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Nakatsuji
authors.forename: M
authors.initials: M
authors.lastname: Kaido
authors.forename: F
authors.initials: F
authors.lastname: Sugai
authors.forename: M
authors.initials: M
authors.lastname: Nakamori
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: O
authors.initials: O
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Arimura
authors.forename: S
authors.initials: S
authors.lastname: Sakoda
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007163:Immunosorbent Techniques; D020386:Isaacs Syndrome / Q000628:therapy*; D010956:Plasmapheresis / Q000379:methods*