Targeting of mRNAs within the glial cell cytoplasm: how to hide the message along the journey.
The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain where they are turned on remains a mystery. This review focuses on aspects of mRNA targeting and speculates on possible molecular mechanisms for the translational control of myelin-located mRNAs.
Boccaccio
G L
GL
Instituto de Investigaciones Bioquímicas "Fundación Campomar," IIB Buenos Aires, CONICET, IIB-FCEyN, University of Buenos Aires, Buenos Aires, Argentina. gboccac@iib.uba.ar
D000818:Animals; D001692:Biological Transport / Q000235:genetics*; D002451:Cell Compartmentation / Q000235:genetics*; D003593:Cytoplasm / Q000378:metabolism* / Q000648:ultrastructure; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D006801:Humans; D004676:Myelin Basic Protein / Q000096:biosynthesis / Q000235:genetics*; D009836:Oligodendroglia / Q000378:metabolism* / Q000648:ultrastructure; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics
D004676:Myelin Basic Protein; D012333:RNA, Messenger