Generalized cutaneous depigmentation following sulfamide-induced drug eruption.
A 41-year-old male developed a generalized drug eruption following sulfamide therapy, with progressive albino-like generalized cutaneous depigmentation. Electron microscopy showed the absence of melanocytes, and clear cells with Langerhans cell characteristics were seen along the basal layer. The present case constitutes a unique reaction to sulfamides not previously reported in the literature.
Martínez-Ruiz
E
E
Department of Dermatology, Hospital Clínico Universitario, Valencia, Spain.
Ortega
C
C
Calduch
L
L
Molina
I
I
Montesinos
E
E
Revert
A
A
Cardá
C
C
Navarro
V
V
Jordá
E
E
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D017496:Hypopigmentation / Q000139:chemically induced*; D008297:Male; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination