title: Visual evoked potentials in cerebral white matter hyperintensity on MRI.
abstract: OBJECTIVE
  To investigate the correlation of the cerebral white matter hyperintensities (WMH) on MRI, and latency and amplitude of visual evoked potentials (VEPs) in elderly subjects.
  
  
  METHODS
  Pattern VEP (PVEP) and flash VEP (FVEP) were recorded in 25 patients with WMH consisting of 12 patients with frontal dominant WMH (FMH) and 13 patients with occipital dominant WMH (OMH) and 25 patients with basal ganglionic hyperintensities (BGH).
  
  
  RESULTS
  In WMHs, there were significantly larger P100 and P2 amplitudes than in BGHs and controls. Regarding the distribution of WMH, OMH showed significantly larger P100 amplitudes than FMH. In OMH in males, there was significantly prolonged P100 latency compared with females, and in females, there were significantly larger P100 and P2 amplitudes compared with males.
  
  
  CONCLUSIONS
  Appropriate clinical values in VEP should take into consideration WMH in addition to gender and age-related changes.
authors.affiliation: Department of Neurology, Neurological Institute, Tokyo Women's Medical University, Japan. br7k-sbt@asahi-net.or.jp
authors.forename: K
authors.initials: K
authors.lastname: Shibata
authors.forename: M
authors.initials: M
authors.lastname: Osawa
authors.forename: M
authors.initials: M
authors.lastname: Iwata
mesh_terms: D000368:Aged; D001921:Brain / Q000033:anatomy & histology*; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged