Influence of pre-examination starvation on liver uptake of the hepatocyte-specific contrast medium FP 736-04 at CT. An experimental study in the rat.
OBJECTIVE
To investigate the effect of starvation on contrast-enhanced CT of the liver using the iodinated hepatocyte-specific lipid emulsion FP 736-04.


METHODS
CT examination of the liver was performed in Sprague-Dawley rats before and after an i.v. infusion of 1.0 ml/kg b.w. of FP 736-04. The examination was preceded by a 15-h period of food withdrawal (the starvation group). A control group was subjected to the same CT examination protocol with use of FP 736-04 but without prior starvation.


RESULTS
Liver attenuation values did not differ significantly between the starvation and the control group (p>0.05).


CONCLUSIONS
A pre-examination period of starvation had no effect on FP 736-04 liver enhancement on CT However, liver attenuation tended to decrease more slowly in the starvation group than in the controls.
Bergman
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A
Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Sweden.
Magnusson
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A
D000818:Animals; D002784:Cholesterol / Q000493:pharmacokinetics; D003287:Contrast Media / Q000493:pharmacokinetics*; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics; D005260:Female; D007459:Iodized Oil / Q000493:pharmacokinetics; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013217:Starvation / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; C106557:FP 736-04; D005217:Fat Emulsions, Intravenous; D007459:Iodized Oil; D002784:Cholesterol