Analysis of different versions of the IARC p53 database with respect to G-->T transversion mutation frequencies and mutation hotspots in lung cancer of smokers and non-smokers.
Analysis of the IARC p53 database revealed a large number of discrepancies in the classification of smoking status for identical lung cancer entries in different versions of the database. In addition, no statistically significant differences in G-->T transversion mutation frequencies or in mutational hotspots at codons 157, 248 and 273 were found in the R3 version of the database between p53 sequences from smoking and non-smoking lung cancer patients. The possible influence of confounding factors on p53 mutation spectra was demonstrated as illustrated by the impact of ethnicity on G-->T transversion mutation frequencies.
Paschke
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Analytisch-Biologisches Forschungslabor, Goethestrasse 20, D-80336 Munich, Germany.
D003062:Codon; D016208:Databases, Factual; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics*; D009154:Mutation; D012907:Smoking
D003062:Codon