title: Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer.
abstract: Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity.
authors.affiliation: Department of Discovery Research, Welfide Corporation, Osaka, Japan. kitajima_hiroshi@welfide.co.jp
authors.forename: H
authors.initials: H
authors.lastname: Kitajima
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Tamakawa
authors.forename: N
authors.initials: N
authors.lastname: Goto
mesh_terms: D000818:Animals; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001597:Benzylidene Compounds; D007004:Hypoglycemic Agents; D007328:Insulin; D013386:Succinates; D014280:Triglycerides