Breast Cancer: A Revolutionary Concept.
In this paper we trace the evolution of paradigms concerning the nature of breast cancer and their therapeutic consequences. There is no doubt that the conceptual revolution of about 20 years ago has led to modest gains in survival following the use of adjuvant systemic therapy and the quality of survival by demonstrating the safety of conservative surgical regimens. At the same time, there seems to be a plateau in progress. The results of adjuvant systemic therapy are not as good as anticipated and there are a number of other inconsistencies within the conventional model of biological predeterminism that remain to be explained. We offer up an alternative paradigm that suggests that not all metastases are due to cellular dissemination with late onset local and distant recurrence resulting from a transfection phenomenon, whereby subcellular particles shed by the primary cancer cell are taken up by wandering cells of the monocyte macrophage system and transported to distant sites where the local mesenchymal cells are transfected with the genetic information that activates components of the genome to instruct these plastic cells to express the phenotypic picture of a dedifferentiated breast duct epithelial cell. Such a conceptual revolution will open up the way for a new program of research and the development of therapies based on anti-viral rather than cytotoxic drugs.
Baum
M
Surgery, The Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
Colletta
A