title: Influence of personal factors on nasal patency and lavage biomarkers in white-collar workers.
abstract: Large biological variability between subjects has been shown for both acoustic rhinometry and nasal lavage biomarker concentrations, but relatively little is known about the influence of personal factors on these techniques. The aim was to evaluate if nasal symptoms, acoustic rhinometric measurements and nasal lavage fluid biomarkers are related to age, gender, smoking, atopy or asthma. A standardized nasal investigation was applied in 411 white-collar workers, belonging to three occupational groups: school personnel (n = 234), office workers (n = 89) and hospital workers (n = 88). Lavage fluid analysis included determination of eosinophil cationic protein (ECP), myeloperoxidase (MPO), lysozyme and albumin. Females had smaller nasal dimensions in the anterior part of the nose (p < 0.001), and lower lavage fluid concentrations of ECP (p = 0.004), MPO (p = 0.002), and albumin (p = 0.01). Rhinometric dimensions or lavage fluid biomarker concentrations were not related to age, smoking, atopy or asthma. Some differences in rhinometric and biomarker measurements were observed between the occupational groups, and adjustment was made for occupation. Rhinometric measures and lavage biomarkers were consistently interrelated, which suggests a combined mucosal swelling and inflammatory reaction. This indicates a potential usefulness of a combined use of acoustic rhinometry and lavage biomarkers to study nasal mucosal reactions.
authors.affiliation: Department of Medical Sciences/Occupational and Environmental Medicine, University of Uppsala, Sweden. robert.walinder@medsci.uu.se
authors.forename: R
authors.initials: R
authors.lastname: Wålinder
authors.forename: G
authors.initials: G
authors.lastname: Wieslander
authors.forename: D
authors.initials: D
authors.lastname: Norbäck
authors.forename: C
authors.initials: C
authors.lastname: Erwall
authors.forename: P
authors.initials: P
authors.lastname: Venge
mesh_terms: D000418:Albumins / Q000032:analysis; D001249:Asthma / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D008297:Male; D009113:Muramidase / Q000032:analysis; D017817:Nasal Lavage Fluid / Q000737:chemistry*; D009297:Nasal Mucosa / Q000502:physiology*; D015508:Nasal Obstruction / Q000503:physiopathology; D009790:Occupations; D009195:Peroxidase / Q000032:analysis; D012130:Respiratory Hypersensitivity / Q000503:physiopathology; D012260:Ribonucleases; D012907:Smoking / Q000503:physiopathology
chemical_list: D000418:Albumins; D015415:Biomarkers; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D009195:Peroxidase; D012260:Ribonucleases; D009113:Muramidase