Humoral factors in intestinal adaptation.
The small bowel has a remarkable ability to adapt after injury, inflammation or resection. It has long been suggested that humoral factors, particularly enteroglucagon, epidermal growth factor, neurotensin and growth hormone/insulin-like growth factor I, might stimulate bowel growth. Of particular interest is the recent finding that glucagon-like peptide 2 (GLP-2), a product of the gene encoding proglucagon, exerts a trophic effect on the intestinal epithelium via a specific G-protein-coupled receptor. GLP-2 and/or these other trophic peptides might prove to have a role in the treatment of bowel diseases associated with structural or functional loss of the small bowel.
Baksheev
L
L
Prince Henry's Institute of Medical Research and Monash University Department of Medicine, Monash Medical Centre, PO Box 5152, Clayton, Victoria 3168, Australia.
Fuller
P J
PJ
D000222:Adaptation, Physiological / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D005768:Gastrointestinal Hormones / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D013045:Species Specificity
D005768:Gastrointestinal Hormones