title: [Minimal mathematical model of the energetic coupling of cotransport and anion-exchange mechanisms for transport in biological membranes].
abstract: A minimal model for the coupling of fluxes of two different anions was constructed, in which one anion Y, is transferred by both the cotransport and anion-exchange pathways, whereas the other anion, Z, only by the anion-exchange mechanism. The possibilities of the model for describing the cooperativity of cotransport and anion-exchange pathways are demonstrated by using the computer simulation approach. It is shown that the energetic coupling of Y and Z anion fluxes becomes possible when the following conditions are fulfilled: (1) The inward-directed flux of Y by the cotransport pathway exceeds its anion-exchange flux directed outward; (2) the reorientation probability of the Y-loaded anion-exchanger is higher than that of the unloaded exchanger.
authors.affiliation: St. Petersburg Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, Russia.
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Orlov
authors.forename: Iu T
authors.initials: IuT
authors.lastname: Rebane
authors.forename: E N
authors.initials: EN
authors.lastname: Rebane
mesh_terms: D000838:Anions; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D008962:Models, Theoretical
chemical_list: D000838:Anions