Treatment of Alzheimer's disease: rationale and strategies.
This article reviews the rationale and provides a progress update regarding the major treatment strategies being developed for the prevention and treatment of Alzheimer's disease. Various therapeutic areas are discussed, including acetylcholinesterase inhibitors and other cholinergic agents, antioxidants, anti-inflammatory drugs, hormone replacement therapy, antiamyloid treatment, and neurotrophic agents.
Grundman
M
M
Department of the Neurosciences, Alzheimer's Disease Cooperative Study, University of California, San Diego and La Jolla, California 92037, USA.
Thal
L J
LJ
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D001921:Brain / Q000187:drug effects; D002986:Clinical Trials as Topic; D006801:Humans; D009474:Neurons / Q000187:drug effects; D018697:Nootropic Agents / Q000009:adverse effects / Q000627:therapeutic use*
D018697:Nootropic Agents