title: Leukemia in a patient treated with growth hormone.
abstract: It is well known that growth hormone (GH) therapy is associated with increased risk of development of malignant tumors, especially leukemia. In the case presented, growth hormone treatment was initiated in a 25-year-old patient with hypopituitarism. After 4 months of therapy with thrice a week injections of rhGH, acute myelogenous leukemia developed. It was thought that no clearcut evidence existed to establish a relationship between the growth hormone treatment and development of acute leukemia.
authors.affiliation: Division of Hematology, Istanbul Medical School, University of Istanbul, Capa, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Aktan
authors.forename: R
authors.initials: R
authors.lastname: Tanakol
authors.forename: M
authors.initials: M
authors.lastname: Nalçaci
authors.forename: G
authors.initials: G
authors.lastname: Dinçol
mesh_terms: D000328:Adult; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced* / Q000453:epidemiology; D008297:Male; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone