title: Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase.
abstract: A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).
authors.affiliation: Roche Bioscience, Inflammatory Diseases Unit, Palo Alto, CA 94304, USA. sharon.dankwardt@roche.com
authors.forename: S M
authors.initials: SM
authors.lastname: Dankwardt
authors.forename: R J
authors.initials: RJ
authors.lastname: Billedeau
authors.forename: L K
authors.initials: LK
authors.lastname: Lawley
authors.forename: S C
authors.initials: SC
authors.lastname: Abbot
authors.forename: R L
authors.initials: RL
authors.lastname: Martin
authors.forename: C S
authors.initials: CS
authors.lastname: Chan
authors.forename: H E
authors.initials: HE
authors.lastname: Van Wart
authors.forename: K A
authors.initials: KA
authors.lastname: Walker
mesh_terms: D000595:Amino Acid Sequence; D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*
chemical_list: D019485:Bone Morphogenetic Proteins; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D008666:Metalloendopeptidases; D055395:Bone Morphogenetic Protein 1