title: Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats.
abstract: We investigated the effect of dexamethasone (DEX) on tyrosine hydroxylase (TH) mRNA level, and TH activity and catecholamine levels in the adrenal medulla of the rat. DEX (1 mg/kg/day, s.c.) was administered for 2 days, and a control group was given corn oil. DEX significantly increased systolic blood pressure. TH mRNA level, TH activity, epinephrine level, and norepinephrine level in the adrenal medulla of DEX-treated rats were significantly higher than those of control rats. Also, epinephrine and norepinephrine levels in plasma were significantly higher in DEX-treated rats than in controls. alpha-Methyl-p-tyrosine prevented the DEX-induced blood pressure increase. These results suggest that the catecholamine synthetic pathway may be involved in DEX-induced hypertension.
authors.affiliation: Dept. of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan. yakuri@marianna-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kumai
authors.forename: K
authors.initials: K
authors.lastname: Asoh
authors.forename: T
authors.initials: T
authors.lastname: Tateishi
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000199:Actins / Q000096:biosynthesis / Q000235:genetics; D000313:Adrenal Medulla / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003907:Dexamethasone / Q000633:toxicity*; D004347:Drug Interactions; D004837:Epinephrine / Q000097:blood / Q000378:metabolism; D005938:Glucocorticoids / Q000633:toxicity*; D006973:Hypertension / Q000139:chemically induced* / Q000201:enzymology*; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation; D019805:alpha-Methyltyrosine / Q000494:pharmacology
chemical_list: D000199:Actins; D005938:Glucocorticoids; D012333:RNA, Messenger; D019805:alpha-Methyltyrosine; D003907:Dexamethasone; D014446:Tyrosine 3-Monooxygenase; D009638:Norepinephrine; D004837:Epinephrine