Hypotensive action of coumarin glycosides from Daucus carota.
Daucus carota (carrot) has been used in traditional medicine to treat hypertension. Activity-directed fractionation of aerial parts of D. carota resulted in the isolation of two cumarin glycosides coded as DC-2 and DC-3. Intravenous administration of these compounds caused a dose-dependent (1-10 mg/kg) fall in arterial blood pressure in normotensive anaesthetised rats. In the in vitro studies, both compounds caused a dose-dependent (10-200 microg/ml) inhibitory effect on spontaneously beating guinea pig atria as well as on the K+ -induced contractions of rabbit aorta at similar concentrations. These results indicate that DC-2 and DC-3 may be acting through blockade of calcium channels and this effect may be responsible for the blood pressure lowering effect of the compounds observed in the in vivo studies.
Gilani
A H
AH
Department of Physiology and Pharmacology, The Aga Khan University Medical College, Karachi, Pakistan. anwar.gilani@aku.edu
Shaheen
E
E
Saeed
S A
SA
Bibi
S
S
Irfanullah
Sadiq
M
M
Faizi
S
S
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001011:Aorta; D001794:Blood Pressure / Q000187:drug effects*; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018552:Daucus carota; D004305:Dose-Response Relationship, Drug; D006325:Heart Atria; D006973:Hypertension / Q000188:drug therapy; D007275:Injections, Intravenous; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D003374:Coumarins; D010936:Plant Extracts