Anti-tumor-promoting effects of glycoglycerolipid analogues on two-stage mouse skin carcinogenesis.
Four glycoglycerolipid analogues, 1-O-hexanoyl-2-O-beta-D-glucopyranosyl-sn-glycerol (1), 1-O-hexanoyl-2-O-beta-D-galactopyranosyl-sn-glycerol (2), 2-O-(6-O-hexanoyl-beta-D-galactopyranosyl)-sn-glycerol (3) and 2-O-(6-O-hexanoyl-alpha-D-galactopyranosyl)-sn-glycerol (4), potent in vitro inhibitors of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation, were submitted to an in vivo two-stage mouse skin carcinogenesis test, using dimethylbenz[a]anthracene (DMBA) and TPA. The study was extended to two deacylated galactosylglycerol structures, 1-O-beta-D-galactopyranosyl-sn-glycerol (5) and 3-O-beta-D-galactopyranosyl-sn-glycerol (6). All the tested compounds exhibited remarkable anti-tumor-promoting effects on mouse skin tumor promotion, the 1-hexanoate 2 being the most active among the glycoglycerolipids until now studied.
Colombo
D
D
Dipartimento di Chimica e Biochimica Medica, Università di Milano, Via Saldini 50, 20133, Milan, Italy. diego.colombo@unimi.it
Compostella
F
F
Ronchetti
F
F
Scala
A
A
Toma
L
L
Kuchide
M
M
Tokuda
H
H
Nishino
H
H
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000956:Antigens, Viral / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001681:Biological Assay; D002273:Carcinogens; D005260:Female; D006017:Glycolipids / Q000494:pharmacology; D008055:Lipids / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D012878:Skin Neoplasms / Q000209:etiology* / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors; D013997:Time Factors
D000956:Antigens, Viral; D000970:Antineoplastic Agents; D002273:Carcinogens; C033305:Epstein-Barr virus early antigen; D006017:Glycolipids; D008055:Lipids; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate