[Fractionated radiation therapy long-term effectiveness in the treatment of cerebello-pontine angle schwannomas: 12 years of experience in 30 cases].
The purpose of this research was to evaluate long-term results of fractionated radiation therapy (RT) in the treatment of cerebello-pontine angle schwannomas.


METHODS
from January 1986 to October 1995, 29 patients with stage III and IV scwhannomas were treated with external fractionated RT. One patient was irradiated on both sides and indication for RT was as follows: a) poor general condition or old age contraindicating surgery, 16 cases; b) hearing preservation in bilateral tumors after contralateral tumor removal, 6 cases; c) partial resection or high risk of recurrence after subsequent surgery for relapse, 5 cases; d) non surgical relapse, 3 cases. Most patients were irradiated with 6 to 10 MV photons. A three- to four-field technique with coplanar static beams and conformal blocks was used. Doses were calculated on a 95 % isodose and were given 5 days a week for a mean total dose of 51 Gy (1.8 Gy/fraction).


RESULTS
Median follow-up from RT was 66 months (7 to 120); seven patients died, two with progressive disease, five from non tumoral cause. Two patients underwent total removal after RT (1 stable and 1 growing tumor). On the whole, tumor shrinkage was observed in 13 patients (43.3 %), stable disease in 14 (46.6 %), and tumor progression in three. Hearing was preserved in 4 out of 6 hearing patients (1 class A hearing, 2 class B and 1 class C). No patient experienced CN5 or CN7 neuropathy.


CONCLUSIONS
long-term efficacy or fractionated RT is well documented in this series. Acute and delayed tolerance was excellent. Hearing can be preserved for a long time.
Darrouzet
V
V
Service d'ORL, Clinique Universitaire d'ORL, Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux Cedex. vincent.darrouzet@chu-aquitaine.fr
Maire
J P
JP
Guérin
J
J
Duclos
J Y
JY
Caudry
M
M
Bébéar
J P
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009464:Neuroma, Acoustic / Q000145:classification / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy*; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome