title: A CD-1 mouse model of infection with Staphylococcus aureus: influence of gender on infection with MRSA and MSSA isolates.
abstract: Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscessation, toxemia, and other infectious diseases. An animal model using CD-1 mice was developed to study the pathogenesis of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). When inoculated into the CD-1 mouse model, it was shown that both MSSA isolates, (HR 78 and CSA-1) and MRSA isolates (MRSA 456 and MRSA 457) led to chronic infection of the kidney. Female CD-1 mice inoculated with MRSA 456 proved to be more susceptible to infection and mortality than their male counterparts. Castrated mice became more susceptible to infection than intact male mice, suggesting a hormonal involvement in the infection process.
authors.affiliation: Department of Microbiology and Infectious Diseases, University of Calgary, Canada.
authors.forename: S J
authors.initials: SJ
authors.lastname: Yanke
authors.forename: M E
authors.initials: ME
authors.lastname: Olson
authors.forename: H D
authors.initials: HD
authors.lastname: Davies
authors.forename: D A
authors.initials: DA
authors.lastname: Hart
mesh_terms: D000818:Animals; D002369:Castration; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D051379:Mice; D010406:Penicillins / Q000494:pharmacology; D012737:Sex Factors; D013203:Staphylococcal Infections / Q000382:microbiology / Q000503:physiopathology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000472:pathogenicity*
chemical_list: D010406:Penicillins; D008712:Methicillin