Marginal corneal infiltrates: a possible new manifestation of sinus histiocytosis with massive lymphadenopathy.
OBJECTIVE
To describe unilateral deep marginal corneal infiltrates and chronic anterior uveitis in a young patient with sinus histiocytosis and massive lymphadenopathy.


METHODS
A 20-year-old man with a painless enlargement of his cervical lymph nodes was followed for five years after debulking of these nodes on the right side for right chronic anterior uveitis and deep marginal corneal infiltrates.


RESULTS
Histological sections of cervical lymph node confirmed the diagnosis of sinus histiocytosis with the typical emperipolesis. The uveitis partially responded to topical corticosteroid treatment but tended to recur upon its withdrawal. The marginal corneal infiltrates resolved gradually over a period of five years.


CONCLUSIONS
Marginal corneal infiltrates and uveitis may presumably be associated with sinus histiocytosis. Patients with sinus histiocytosis should also be screened for rare ocular involvement, such as uveitis and corneal infiltrates.
Rumelt
S
S
Department of Ophthalmology, Western Galilee-Nahariya Medical Center, Nahariya, Israel.
Cohen
I
I
Rehany
U
U
D000328:Adult; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000008:administration & dosage; D015618:Histiocytosis, Sinus / Q000150:complications* / Q000473:pathology; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D009883:Ophthalmic Solutions; D012008:Recurrence; D014606:Uveitis, Anterior / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D014792:Visual Acuity
D005938:Glucocorticoids; D009883:Ophthalmic Solutions