Effect of water-soluble carriers on dissolution characteristics of nifedipine solid dispersions.
Solid dispersions of nifedipine (NP) with polyethylene glycols (PEG4000 and PEG6000), hydroxypropyl-beta-cyclodextrin (HP beta CD), and poloxamer 407 (PXM 407) in four mixing ratios were prepared by melting, solvent, and kneading methods in order to improve the dissolution of NP. The enhancement of the dissolution rate and the time for 80% NP dissolution T80% depended on the mixing ratio and the preparation method. The highest dissolution rate and the T80% as short as 15 min were obtained from PXM 407 solid dispersion prepared by the melting method at the mixing ratio of 1:10. The X-ray diffraction (XRD) patterns of solid dispersions at higher proportions of carriers demonstrated consistent with the results from differential scanning calorimetric (DSC) thermograms that NP existed in the amorphous state. The wettability and solubility were markedly improved in the PXM 407 system. The presence of intermolecular hydrogen bonding between NP and PEGs and between HP beta CD and PXM 407 was shown by infrared (IR) spectroscopy.
Chutimaworapan
S
S
Faculty of Pharmaceutical Sciences, Chulalongkom University, Bangkok, Thailand.
Ritthidej
G C
GC
Yonemochi
E
E
Oguchi
T
T
Yamamoto
K
K
D002121:Calcium Channel Blockers; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods*; D009543:Nifedipine; D011092:Polyethylene Glycols; D012995:Solubility; D013055:Spectrophotometry, Infrared
D002121:Calcium Channel Blockers; D004337:Drug Carriers; D011092:Polyethylene Glycols; D009543:Nifedipine