Adapalene: an update on newer comparative studies between the various retinoids.
BACKGROUND
Extensive modification of the retinoic acid molecular skeleton has resulted in the development of adapalene, a more stable, less irritating compound with receptor selectivity. Adapalene selectively targets nuclear retinoic acid receptors found primarily in the epidermis. Pharmacologic and preclinical studies have demonstrated excellent follicular penetration, comedolytic activity, and anti-inflammatory activity.


METHODS
Recent comparative trials were reviewed.


RESULTS
Adapalene is a useful new agent because of its tolerability and stability. It is a good therapeutic choice for combination with other topical anti-acne medications, such as antimicrobials or benzoyl peroxide. Patient compliance with either combination or single-agent adapalene regimens is likely to be enhanced because of the greater comfort and reduced skin irritation associated with the new compound. Other investigators have confirmed that adapalene gel produces consistent and significantly reduced irritation.


CONCLUSIONS
Recent comparative trials on retinoids have provided new data to aid in the selection of the appropriate combination of topical agents for individual patients.
Millikan
L E
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Department of Dermatology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA. millikan@tmcpop.tmc.tulane.edu
D000068816:Adapalene; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D009281:Naphthalenes / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003879:Dermatologic Agents; D009281:Naphthalenes; D000068816:Adapalene