Retinal toxicity of triamcinolone acetonide in silicone-filled eyes.
OBJECTIVE
To determine the retinal toxicity of triamcinolone acetonide at different doses in vitrectomized, silicone-filled rabbit eyes.


METHODS
Vitrectomy with silicone oil placement was performed in 32 rabbit eyes. A dosage of 1 mg/0.025 mL, 2 mg/0.05 mL, or 4 mg/0.1 mL of triamcinolone acetonide was injected intravitreally in the study group eyes; the control group received 0.1 mL of sterile saline. Electroretinography and retinal histology were performed to evaluate toxicity.


RESULTS
No retinal toxicity was seen in the groups given 1, 2, and 4 mg of triamcinolone acetonide or in the control group. ERG and histologic sections in all groups were normal. No drug was visible in the vitreous cavity at the end of the 140-day period (average) in eyes injected with 4 mg of triamcinolone acetonide.


CONCLUSIONS
Up to 4 mg of triamcinolone acetonide can be safely injected in silicone-filled, vitrectomized eyes without any significant retinal toxicity.
Kivilcim
M
M
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans, USA.
Peyman
G A
GA
El-Dessouky
E S
ES
Kazi
A A
AA
Cheema
R
R
Hegazy
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004596:Electroretinography / Q000187:drug effects; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000633:toxicity*; D007267:Injections; D008297:Male; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D012827:Silicone Oils / Q000008:administration & dosage*; D018675:Toxicity Tests; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000633:toxicity*; D014821:Vitrectomy / Q000379:methods*; D014822:Vitreous Body
D005938:Glucocorticoids; D012827:Silicone Oils; D014222:Triamcinolone Acetonide