title: Restoration of immunity with interleukin-2 therapy.
abstract: HIV replication can now be effectively suppressed using antiretroviral combination regimens. The search continues, however, for ways to restore the immune response and eliminate reservoirs of latent infection. Interleukin-2 (IL-2) may augment the immune response in HIV-infected persons. This article discusses the rationale for using IL-2 in those with HIV disease and reviews key trials of IL-2 treatment regimens.
authors.affiliation: Department of Medicine, Weill Medical College of Cornell University, New York, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Smith
authors.forename: E L
authors.initials: EL
authors.lastname: Jacobson
authors.forename: R
authors.initials: R
authors.lastname: Emert
authors.forename: M
authors.initials: M
authors.lastname: Giordano
authors.forename: E
authors.initials: E
authors.lastname: Kovacs
authors.forename: N
authors.initials: N
authors.lastname: Mumneh
authors.forename: F
authors.initials: F
authors.lastname: Pilaro
authors.forename: T
authors.initials: T
authors.lastname: Sohn
authors.forename: D
authors.initials: D
authors.lastname: Warren
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007109:Immunity / Q000187:drug effects; D007167:Immunotherapy; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000187:drug effects / Q000276:immunology; D017735:Virus Latency / Q000187:drug effects / Q000276:immunology
chemical_list: D007376:Interleukin-2; D015375:Receptors, Interleukin-2