[A novel fibrin clot with a sustained release of cis-platinum (CDDP)].
The authors devised a novel fibrin clot (FC) using an ultra-violet (UV)-crosslinking method. CDDP was impregnated into FCs, and the release profiles of the CDDP were examined in vitro. The microstructures of the FCs were studied with scanning electron microscopy (SEM). The release of CDDP from the FC-UV-CDDP was maintained for 10 days, while that from the FC-CDDP showed initial bursting with a following plateau of CDDP concentrations. SEM of UV-crosslinked FCs revealed highly organized, close and homogeneous micropore structures. Native FCs and non-crosslinked FCs showed rough fibrin networks with entangling fibrin fibers. These microstructural differences may play important roles in the release profiles of CDDP. Our newly devised UV-crosslinked material is promising as a drug carrier for sustained release.
Sugitachi
A
A
1st Dept. of Surgery, Iwate Medical University.
Takagane
A
A
Terashima
M
M
Kashiwaba
M
M
Shimada
H
H
Asahi
H
H
Saitoh
K
K
D002945:Cisplatin / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D015718:Fibrin Tissue Adhesive / Q000737:chemistry*; D006801:Humans; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D015718:Fibrin Tissue Adhesive; D002945:Cisplatin