title: Lytic growth of human herpesvirus 8: morphological aspects.
abstract: The human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus, is a gamma herpesvirus associated with AIDS-related body cavity-based lymphomas (BCBL), also called primary effusion lymphomas (PEL). These are a rare form of non-Hodgkin lymphomas in which HHV-8 is present, often associated with Epstein-Barr virus (EBV) infection. HHV-8 is also present in a latent state or in a state of low-level persistence in different primary effusion lymphoma-derived cell lines, such BCBL-1 cells, that lack EBV infection. This cell line was induced to produce mature virions by treatment with 12-O-tetradecanoyl phorbol-13-acetate (TPA) and the characteristic ultrastructural features of HHV-8 lytic replication were identified and compared to those of the other members of Herpesviridae family.
authors.affiliation: Laboratory of Ultrastructure, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tinari
authors.forename: P
authors.initials: P
authors.lastname: Monini
authors.forename: M
authors.initials: M
authors.lastname: Marchetti
authors.forename: M G
authors.initials: MG
authors.lastname: Ammendolia
authors.forename: P
authors.initials: P
authors.lastname: Leone
authors.forename: B
authors.initials: B
authors.lastname: Ensoli
authors.forename: F
authors.initials: F
authors.lastname: Superti
mesh_terms: D017209:Apoptosis; D002087:Butyrates / Q000494:pharmacology; D019288:Herpesvirus 8, Human / Q000145:classification / Q000187:drug effects / Q000254:growth & development* / Q000648:ultrastructure; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000648:ultrastructure / Q000821:virology; D008854:Microscopy, Electron; D015388:Organelles / Q000648:ultrastructure; D016066:Pleural Effusion, Malignant / Q000473:pathology / Q000821:virology; D012514:Sarcoma, Kaposi / Q000648:ultrastructure / Q000821:virology*; D013045:Species Specificity; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014779:Virus Replication
chemical_list: D002087:Butyrates; D013755:Tetradecanoylphorbol Acetate