title: Surgical repair of full-thickness idiopathic macular holes associated with significant macular drusen.
abstract: OBJECTIVE
  To evaluate the visual and anatomic results of surgically repaired macular holes in eyes with intermediate or large-sized macular drusen.
  
  
  METHODS
  Retrospective noncomparative case series.
  
  
  METHODS
  Thirty-four eyes of 32 patients undergoing macular hole surgery with preoperative intermediate or large-sized macular drusen as defined by the Age-Related Eye Disease Study (AREDS).
  
  
  METHODS
  Pars plana vitrectomy for standard macular hole repair performed by multiple surgeons.
  
  
  METHODS
  Visual acuity, anatomic hole closure.
  
  
  RESULTS
  Initial hole closure failed in 8 eyes (24%) overall, 5 of 28 eyes (18%) with AREDS category 2 drusen and 3 of 6 eyes (50%) with category 3 drusen (P = 0.1263). Final macular hole closure was seen in 93% of category 2 and 67% of category 3 eyes (P = 0.1347). Mean final visual acuity was 20/60 overall, 20/60 for category 2, and 20/50 for category 3 eyes.
  
  
  CONCLUSIONS
  A trend of reduced initial macular hole closure was seen in eyes with significant macular drusen. Reoperation improved closure rates. If closure was accomplished, visual outcomes were excellent.
authors.affiliation: Associated Retinal Consultants, PC, Department of Ophthalmology, Beaumont Eye Institute, Royal Oak, Michigan, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Berinstein
authors.forename: T S
authors.initials: TS
authors.lastname: Hassan
authors.forename: G A
authors.initials: GA
authors.lastname: Williams
authors.forename: R R
authors.initials: RR
authors.lastname: Margherio
authors.forename: A J
authors.initials: AJ
authors.lastname: Ruby
authors.forename: B R
authors.initials: BR
authors.lastname: Garretson
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008266:Macula Lutea; D008297:Male; D015593:Retinal Drusen / Q000150:complications* / Q000503:physiopathology; D012167:Retinal Perforations / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy