title: Bioactive saponins from Swartzia schomburgkii from the suriname rainforest.
abstract: Bioassay-guided fractionation of the MeOH extract of Swartzia schomburgkii using the engineered yeast strains 1138, 1140, and 1353 as the bioassay tool resulted in the isolation of five active (2, 4-7) and three inactive (1, 3, 8) saponins. Saponins 4 and 6 are previously unreported. The structures of all of the saponins were established based on 1D and 2D NMR spectral analysis, on acid and alkaline hydrolysis followed by TLC and GC-MS, and by comparison with literature data for known compounds. Three of the isolated compounds (4-6) showed weak cytotoxicity against the M-109 cell line.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Abdel-Kader
authors.forename: B D
authors.initials: BD
authors.lastname: Bahler
authors.forename: S
authors.initials: S
authors.lastname: Malone
authors.forename: M C
authors.initials: MC
authors.lastname: Werkhoven
authors.forename: J H
authors.initials: JH
authors.lastname: Wisse
authors.forename: K M
authors.initials: KM
authors.lastname: Neddermann
authors.forename: I
authors.initials: I
authors.lastname: Bursuker
authors.forename: D G
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000032:analysis* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013532:Suriname; D014407:Tumor Cells, Cultured
chemical_list: D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins