title: Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation.
abstract: A 32-year-old patient developed an anaphylactic reaction minutes after oral intake of acetaminophen-containing tablets (Doregrippin)). Scratch testing of the whole preparation was positive in contrast with the negative results obtained with pure acetaminophen. Therefore, scratch tests with the remaining drug components were performed and showed polyvinylpyrrolidone (PVP) to be the aetiological agent. Furthermore, specific IgE antibodies against PVP were demonstrated using a dot blot technique, thus ruling out a pseudo-allergic reaction. This case underlines the necessity to consider not only the active ingredient, but also additives as the causative agent.
authors.affiliation: Department of Dermatology, Heinrich-Heine-University, Moorenstrasse 5, 40225 Duesseldorf, Germany. AndreaCR@bigfoot.com
authors.forename: A C
authors.initials: AC
authors.lastname: Rönnau
authors.forename: M
authors.initials: M
authors.lastname: Wulferink
authors.forename: E
authors.initials: E
authors.lastname: Gleichmann
authors.forename: E
authors.initials: E
authors.lastname: Unver
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
authors.forename: J
authors.initials: J
authors.lastname: Krutmann
authors.forename: M
authors.initials: M
authors.lastname: Grewe
mesh_terms: D000082:Acetaminophen; D000328:Adult; D018712:Analgesics, Non-Narcotic; D000707:Anaphylaxis / Q000139:chemically induced*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D010592:Pharmaceutic Aids / Q000009:adverse effects*; D011205:Povidone / Q000009:adverse effects*; D012882:Skin Tests
chemical_list: D018712:Analgesics, Non-Narcotic; D010592:Pharmaceutic Aids; D000082:Acetaminophen; D007073:Immunoglobulin E; D011205:Povidone