Intragastric beta-casomorphin(1-7) attenuates the suppression of fat intake by enterostatin.
The current experiments were designed to compare the feeding response to enterostatin and beta-casomorphin(1-7) injected intragastrically. Sprague-Dawley rats with a gastric cannula were allowed to chose from high-fat diet (HF) or low-fat diet (LF) in separate jars. Enterostatin injected intragastrically into overnight fasted rats caused a U-shaped dose-dependent reduction in the intake of the HF diet for the first two hours after infusion but had no effect on the LF intake. beta-Casomorphin(1-7) stimulated the intake of the HF diet but had no effect on the LF diet. Finally, beta-casomorphin(1-7) blocked the inhibitory effect of enterostatin on HF intake in fasted rats.
White
C L
CL
Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA.
Bray
G A
GA
York
D A
DA
D000818:Animals; D003089:Colipases / Q000494:pharmacology*; D004041:Dietary Fats / Q000378:metabolism*; D004336:Drug Antagonism; D004435:Eating / Q000187:drug effects*; D004723:Endorphins / Q000494:pharmacology*; D004792:Enzyme Precursors; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D013270:Stomach / Q000187:drug effects
D003089:Colipases; D004041:Dietary Fats; D004723:Endorphins; D004792:Enzyme Precursors; D010446:Peptide Fragments; D011498:Protein Precursors; D011956:Receptors, Cell Surface; C117600:enterostatin receptor; C041128:beta-casomorphin 7; C037107:procolipase