Immune effects and mechanisms of action of CpG motifs.
Bacterial DNA differs from vertebrate DNA in having a much higher content of unmethylated CpG dinucleotides, in particular, base contexts that are termed 'CpG motifs'. The vertebrate immune system appears to have evolved pattern recognition molecules that recognize 'CpG motifs' as foreign, and trigger protective immune responses which are strongly Th1-biased. These responses can be mimicked using synthetic oligodeoxyribonucleotides, which have demonstrated remarkable utility as vaccine adjuvants and as immunotherapeutics for treatment of cancer and allergic diseases.
Krieg
A M
AM
Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA. arthur-krieg@uiowa.edu
D000276:Adjuvants, Immunologic / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D018899:CpG Islands / Q000276:immunology*; D004269:DNA, Bacterial / Q000276:immunology; D007110:Immunity, Active; D007111:Immunity, Cellular; D051379:Mice; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology* / Q000627:therapeutic use* / Q000633:toxicity
D000276:Adjuvants, Immunologic; D004269:DNA, Bacterial; D019444:Vaccines, DNA