Effect of ethanol on defibrillation energy requirements in humans.
The purpose of this double-blind study was to determine the effect of intravenous ethanol administration on defibrillation efficacy in 18 patients with an implantable defibrillator. The equivalent of 60 ml of 100 proof ethanol did not impair defibrillation efficacy.
Strickberger
S A
SA
Department of Pharmacology, The University of Michigan Medical Center, Ann Arbor 48109-0022, USA.
Bleske
B E
BE
Davidson
T
T
Papasafakis
E N
EN
Pelosi
F
F
Michaud
G F
GF
Knight
B P
BP
Morady
F
F
D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000150:complications*; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D003327:Coronary Disease / Q000150:complications*; D017147:Defibrillators, Implantable; D004311:Double-Blind Method; D016903:Drug Monitoring; D004734:Energy Metabolism; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D013318:Stroke Volume; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*
D002492:Central Nervous System Depressants; D000431:Ethanol