Molecular domains of myelinated axons.
Myelinated axons are organized into specific domains as the result of interactions with glial cells. Recently, distinct protein complexes of cell adhesion molecules, Na(+) channels and ankyrin G at the nodes, Caspr and contactin in the paranodes, and K(+) channels and Caspr2 in the juxtaparanodal region have been identified, and new insights into the role of the paranodal junctions in the organization of these domains have emerged.
Peles
E
E
Department of Molecular Cell Biology, The Weizmann Institute of Science, 76100, Rehovot, Israel. peles@weizmann.ac.il
Salzer
J L
JL
D000818:Animals; D001369:Axons / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology; D009186:Myelin Sheath / Q000737:chemistry / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*
D007473:Ion Channels; D009419:Nerve Tissue Proteins