[Contents of the main erythrocyte membrane proteins in patients with primary arterial hypertension and its relationship with hereditary predisposition to cardiovascular diseases].
OBJECTIVE
To study quantitative content of main erythrocyte membrane proteins in patients with primary arterial hypotension and its relationship with hereditary predisposition to cardiovascular disease.


METHODS
Quantitative content of main erythrocyte membrane proteins in 109 patients with primary arterial hypotension (PAH) and 124 healthy persons was measured with unidimensional polyacrylamide gel electrophoresis. Hereditary determination of PAH was studied by the clinical-genealogical method.


RESULTS
PAH patients showed quantitative alterations in erythrocyte membrane protein composition: increased content of alpha-spectrin, ankyrin (band 2.1), anion exchange protein (band 3) and decreased content of actin, tropomyosin and glutathione-S-transferase. Patients with aggravated heredity for PAH had higher content of beta-spectrin and ankyrin (band 2.1 and 2.2) then patients without aggravated heredity for PAH.


CONCLUSIONS
Quantitative alterations of membrane proteins in patients with PAH could significantly modify the structure of cytoskeleton and result in modification of the enzyme activity of transmembrane proteins (ATPases) regulating cation transport across erythrocyte membrane. Moreover, aggravated heredity for PAH predisposes to high content of cytoskeletal proteins (beta-spectrin, 2.1 and 2.2 ankyrin) which could form more compact structure of erythrocyte membrane and limit cation influx into cytoplasma.
Ivanov
V P
VP
Polonikov
A V
AV
Solodilova
M A
MA
Lukashov
A A
AA
D000293:Adolescent; D000328:Adult; D017487:Ankyrins / Q000097:blood; D002318:Cardiovascular Diseases / Q000235:genetics*; D003627:Data Interpretation, Statistical; D004591:Electrophoresis, Polyacrylamide Gel; D004910:Erythrocyte Membrane / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics*; D008565:Membrane Proteins / Q000032:analysis*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000235:genetics; D013049:Spectrin / Q000032:analysis; D014335:Tropomyosin / Q000097:blood; D014648:Varicose Veins / Q000235:genetics
D017487:Ankyrins; D008565:Membrane Proteins; D014335:Tropomyosin; D013049:Spectrin; D005982:Glutathione Transferase