title: Detection of rare malignant cells and their apoptotic fragments in cerebrospinal fluid.
abstract: Routine cerebrospinal fluid cytology often fails to detect small numbers of malignant cells exfoliated from primary lymphomas of the central nervous system and metastatic carcinomas. Immunocytochemistry on poly-L-lysine-coated slides was optimised to permit unequivocal identification of a single carcinoma cell in 1 mL of cerebrospinal fluid, as well as carcinoma cell-derived apoptotic bodies that themselves contribute to enhanced diagnostic sensitivity.
authors.forename: B R
authors.initials: BR
authors.lastname: Kranz
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D017209:Apoptosis; D016543:Central Nervous System Neoplasms / Q000134:cerebrospinal fluid* / Q000378:metabolism / Q000473:pathology; D003581:Cytodiagnosis / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000134:cerebrospinal fluid* / Q000378:metabolism / Q000473:pathology; D012680:Sensitivity and Specificity
chemical_list: D018951:Antigens, CD20