The utility of polysporin ointment in the eradication of methicillin-resistant Staphylococcus aureus colonization: a pilot study.
We evaluated the efficacy of an ointment containing bacitracin, polymyxin B, and gramicidin for the eradication of colonization by methicillin-resistant Staphylococcus aureus in 11 medical patients, 10 (91%) of whom had previously failed a 1-week course of topical mupirocin. Mupirocin resistance was documented in 5 (45%) of 11 patients. Successful decolonization was achieved in 9 (82%) of 11 patients (based on 2 months of follow-up).
Fung
S
S
Department of Medicine, Toronto General and Toronto Western Hospitals, University of Toronto, Ontario, Canada.
O'Grady
S
S
Kennedy
C
C
Dedier
H
H
Campbell
I
I
Conly
J
J
D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001414:Bacitracin / Q000494:pharmacology*; D004338:Drug Combinations; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D005260:Female; D006096:Gramicidin / Q000494:pharmacology*; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D016712:Mupirocin / Q000494:pharmacology; D009824:Ointments; D010865:Pilot Projects; D011112:Polymyxin B / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009824:Ointments; C420142:polysporin ointment; D001414:Bacitracin; D006096:Gramicidin; D016712:Mupirocin; D011112:Polymyxin B