title: Xenon does not induce contracture in human malignant hyperthermia muscle.
abstract: Xenon has many characteristics of an ideal anaesthetic agent. It is not known whether xenon is a safe alternative to the potent inhalational anaesthetics in patients susceptible to malignant hyperthermia (MH). We investigated the effect of xenon, halothane and caffeine on muscle specimens of 31 individuals, referred to the MH Unit of the University of Ulm, and performed genetic epidemiology. Thirteen individuals were classified as MH susceptible and 18 as MH negative. Xenon 70% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine. The evoked twitch response increased transiently in MH-susceptible and normal specimens indicating a mechanism independent of MH susceptibility. These results suggest that xenon, in concentrations up to 70% may be a safe anaesthetic for MH-susceptible patients.
authors.affiliation: Department of Applied Physiology, University of Ulm, Germany.
authors.forename: C P
authors.initials: CP
authors.lastname: Baur
authors.forename: W
authors.initials: W
authors.lastname: Klingler
authors.forename: K
authors.initials: K
authors.lastname: Jurkat-Rott
authors.forename: G
authors.initials: G
authors.lastname: Froeba
authors.forename: E
authors.initials: E
authors.lastname: Schoch
authors.forename: T
authors.initials: T
authors.lastname: Marx
authors.forename: M
authors.initials: M
authors.lastname: Georgieff
authors.forename: F
authors.initials: F
authors.lastname: Lehmann-Horn
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D020022:Genetic Predisposition to Disease; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D008305:Malignant Hyperthermia / Q000235:genetics / Q000503:physiopathology*; D009119:Muscle Contraction / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000503:physiopathology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D014978:Xenon / Q000494:pharmacology*
chemical_list: D018685:Anesthetics, Inhalation; D010726:Phosphodiesterase Inhibitors; D002110:Caffeine; D014978:Xenon; D006221:Halothane