Cytotoxic prenyleudesmane diterpenes from the fruits of Dysoxylum kuskusense.
Two new prenyleudesmane diterpenes, dysokusone D (1) and dysokusone E (2), were isolated from the fruits of Dysoxylum kuskusense and exhibited cytotoxicity against P-388, HT-29, and A549 cell lines. Their structures were determined by 1D and 2D NMR spectral analysis.
Duh
C Y
CY
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Wang
S K
SK
Chen
I S
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D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D019073:HT29 Cells; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C420036:dysokusone D; C420037:dysokusone E