title: Feasibility of peripheral blood stem cell rescue as intensification in elderly patients with acute myelocytic leukaemia: a pilot study from the Gimema Group. Gruppo Italiano Malattie Ematologiche Maligne Dell'Adulto.
abstract: Elderly patients with untreated acute myeloid leukaemia (AML, n = 47) tested the feasibility of out-patient consolidation therapy and post-consolidation treatment (for patients aged < 71 years) with autologous peripheral blood stem cell transplantation (APBSCT). Overall, 13 patients out of 24 (51%) who achieved complete remission (CR) were eligible for further treatment after consolidation. Five patients were primed with granulocyte colony stimulating factor (G-CSF); a suitable number of CD34+ cells were harvested in three patients and were actually autotransplanted. The toxicity of APBSCT was negligible. Psychosocial problems impaired treatment of some patients on an out-patient basis. Resistant disease, toxicity and logistic problems reduced the number of patients to whom this procedure could actually be applied.
authors.affiliation: Divisione di Ematologia, Ospedale Niguarda Cà Granda, Milan, Italy. m.montillo@tiscalinet.it
authors.forename: M
authors.initials: M
authors.lastname: Montillo
authors.forename: A
authors.initials: A
authors.lastname: Tedeschi
authors.forename: L
authors.initials: L
authors.lastname: Pagano
authors.forename: A
authors.initials: A
authors.lastname: Venditti
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.forename: P
authors.initials: P
authors.lastname: Fabris
authors.forename: B
authors.initials: B
authors.lastname: Martino
authors.forename: M
authors.initials: M
authors.lastname: Musso
authors.forename: G
authors.initials: G
authors.lastname: De Rosa
authors.forename: G
authors.initials: G
authors.lastname: Specchia
authors.forename: M
authors.initials: M
authors.lastname: Monaco
authors.forename: G
authors.initials: G
authors.lastname: Sparaventi
authors.forename: A
authors.initials: A
authors.lastname: Spadea
authors.forename: A
authors.initials: A
authors.lastname: Palmas
authors.forename: W
authors.initials: W
authors.lastname: Deplano
authors.forename: A
authors.initials: A
authors.lastname: Manna
authors.forename: L
authors.initials: L
authors.lastname: Melillo
authors.forename: E
authors.initials: E
authors.lastname: Miraglia
authors.forename: S
authors.initials: S
authors.lastname: Mirto
authors.forename: F
authors.initials: F
authors.lastname: Mandelli
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D005240:Feasibility Studies; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007951:Leukemia, Myeloid / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012074:Remission Induction; D014182:Transplantation, Autologous
chemical_list: D016179:Granulocyte Colony-Stimulating Factor