title: Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production.
abstract: Monocyte phenotype, their phagocytic capacity as well as the cytokine production from 10 patients with sepsis with low interleukin-6 (IL-6) serum concentrations (<1000 pg/mL) and 8 patients with sepsis with high IL-6 (> or = 1000 pg/mL) plasma concentrations were investigated within 24 hours of fulfilling the criteria for sepsis. Monocytes from patients with high IL-6 levels had higher levels of human leukocyte antigen (HLA)-DR, HLA-ABC, CD64, and CD71, and the production of tumor necrosis factor-alpha (TNF-alpha) and IL-8, as well as the capacity of monocytes to phagocytose, was significantly elevated. Of 8 patients with high levels of plasma IL-6, 4 patients died. In contrast, all 10 patients with low plasma IL-6 concentrations survived until day 28. Patients who died had constant high IL-6 concentrations during the first 3 days, whereas IL-6 levels in patients who survived decreased by 88%. Our data indicate that IL-6 levels are a better prognostic parameter in the early phase of sepsis than the monocyte HLA-DR expression.
authors.affiliation: Department of Surgery, Research Laboratories, University of Vienna, Vienna, Austria. a.spittler@akh-wien.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Spittler
authors.forename: M
authors.initials: M
authors.lastname: Razenberger
authors.forename: H
authors.initials: H
authors.lastname: Kupper
authors.forename: M
authors.initials: M
authors.lastname: Kaul
authors.forename: W
authors.initials: W
authors.lastname: Hackl
authors.forename: G
authors.initials: G
authors.lastname: Boltz-Nitulescu
authors.forename: R
authors.initials: R
authors.lastname: Függer
authors.forename: E
authors.initials: E
authors.lastname: Roth
mesh_terms: D000328:Adult; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D010587:Phagocytosis / Q000276:immunology*; D011379:Prognosis; D018805:Sepsis / Q000276:immunology*
chemical_list: D016207:Cytokines; D006684:HLA-DR Antigens; D015850:Interleukin-6