Complex carbohydrate synthesis tools for glycobiologists: enzyme-based approach and programmable one-pot strategies.
The ultimate goal in complex carbohydrate synthesis is to develop synthetic tools which are simple and easily accessible to glycobiologists. This review will describe methods which have the potential to reach this goal, with particular focus on enzymatic and computer-based one-pot approaches for the preparation of complex carbohydrates and glycoconjugates.
Koeller
K M
KM
Department of Chemistry, The Scripps Research Institute and Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Wong
C H
CH
D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry; D016208:Databases, Factual; D015195:Drug Design; D006001:Glycoconjugates / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry; D006017:Glycolipids / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry; D006020:Glycopeptides / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry; D006023:Glycoproteins / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000378:metabolism; D016695:Glycosyltransferases / Q000378:metabolism; D008722:Methods; D008969:Molecular Sequence Data; D009005:Monosaccharides / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry; D009844:Oligosaccharides / Q000096:biosynthesis / Q000138:chemical synthesis / Q000737:chemistry
D002241:Carbohydrates; D006001:Glycoconjugates; D006017:Glycolipids; D006020:Glycopeptides; D006023:Glycoproteins; D009005:Monosaccharides; D009844:Oligosaccharides; D016695:Glycosyltransferases; D006026:Glycoside Hydrolases