Early detection for colorectal cancer: new aspects in fecal occult blood screening.
The authors report on promising diagnostic methods of occult intestinal bleeding and discusses the potential new strategy of early detection of colorectal carcinomas in respect to old and new diagnostic measures available. Because of the limited sensitivity and specificity of classical methods used for the demonstration of occult fecal blood, the authors recommend the introduction of new techniques and markers in screening practice. It is presumed that new discoveries in molecular biology will improve the accuracy of early colorectal cancer prevention. Their implementation into routine screening, however, will not take place in the near future. Until their realization, improved screening efficacy is expected from the use of more specific and sensitive blood tests.
Ottó
S
S
National Institute of Oncology, Department of Clinical Pathology, Budapest, Hungary. sz.otto@oncol.hu
Eckhardt
S
S
D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000517:prevention & control; D006801:Humans; D008403:Mass Screening / Q000379:methods; D009780:Occult Blood; D012680:Sensitivity and Specificity