Characterisation of Crim1 expression in the developing mouse urogenital tract reveals a sexually dimorphic gonadal expression pattern.
The Crim1 gene encodes a putative transmembrane protein with an IGF-binding protein motif and multiple chordin-like cysteine-rich repeats. In chordin, such repeats are responsible for its dorsalising activity and for binding to bone morphogenic proteins (BMPs). Crim1 displays a dynamic expression pattern in a variety of developing organs, including the CNS and the lens. We have undertaken a detailed expression pattern analysis of Crim1 in the developing mouse urogenital system. During metanephric development, Crim1 showed expression both in the ureteric tree, the early condensing mesenchyme and distal comma-shaped bodies. As the nephron elongates, Crim1 becomes expressed in the proximal end of the S-shaped bodies. Crim1 also displays a striking male-specific expression pattern in the fetal gonads, its expression strongest in the Sertoli cells of the developing testis.
Georgas
K
K
Institute for Molecular Bioscience, incorporating the Centre for Molecular and Cellular Biology and the Special Research Centre for Functional and Applied Genomics, The University of Queensland, Brisbane, Australia.
Bowles
J
J
Yamada
T
T
Koopman
P
P
Little
M H
MH
D000818:Animals; D005260:Female; D020869:Gene Expression Profiling; D005854:Germ Cells / Q000737:chemistry; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007668:Kidney / Q000196:embryology / Q000378:metabolism; D008297:Male; D051379:Mice; D009687:Nuclear Proteins; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy; D011506:Proteins; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012727:Sex Characteristics; D013737:Testis / Q000196:embryology / Q000378:metabolism; D014566:Urogenital System / Q000196:embryology* / Q000378:metabolism
D009687:Nuclear Proteins; D011506:Proteins; D016271:Proto-Oncogene Proteins c-myc; C074370:cysteine-rich protein, mammalian