title: [A case of locally advanced breast cancer successfully resected after selective intra-arterial chemotherapy].
abstract: A 25-year-old female with a large tumor on her left breast was examined at our hospital from August, 1999. Ipsilateral supraclavicular, infraclavicular and axillary lymph nodes were swollen. She was diagnosed as having locally advanced breast cancer of stage IIIb by fine needle aspiration cytology. After the administration of docetaxel (60 mg/m2/3 weeks x 3) failed to improve her condition, we changed the treatment to selective intra-arterial chemotherapy with THP-ADR (60 mg/body/day, day 1 & 8, 41 & 48) by Seldinger's method. The target vessels were the internal thoracic, lateral thoracic, thoracodorsal and deep cervical arteries. We also combined 5-FU 500 mg/body div and CPA 500 mg/body i.v. on the same days with intra-arterial chemotherapy. As a result, the main tumor and metastatic lymph node swelling was remarkably reduced (down-staging was obtained). No recurrence was found for 5 months after curative resection.
authors.affiliation: Dept. of Surgery, Suita Municipal Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Shingai
authors.forename: J
authors.initials: J
authors.lastname: Furukawa
authors.forename: T
authors.initials: T
authors.lastname: Azama
authors.forename: K
authors.initials: K
authors.lastname: Takekuni
authors.forename: Y
authors.initials: Y
authors.lastname: Katsumoto
authors.forename: M
authors.initials: M
authors.lastname: Yukawa
authors.forename: K
authors.initials: K
authors.lastname: Nakaguchi
authors.forename: S
authors.initials: S
authors.lastname: Okajima
authors.forename: F
authors.initials: F
authors.lastname: Sue
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: W
authors.initials: W
authors.lastname: Yoshihara
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D000077143:Docetaxel; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D017239:Paclitaxel / Q000008:administration & dosage / Q000031:analogs & derivatives*; D043823:Taxoids
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D004317:Doxorubicin; D003520:Cyclophosphamide; C027260:pirarubicin; D017239:Paclitaxel; D005472:Fluorouracil