HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections.
Protective immunity against Plasmodium falciparum requires constant exposure to the pathogen. T cell-mediated immune responses are induced by T cell epitopes of pre-erythrocytic stage antigens of P. falciparum and involve HLA-restricted CD4 and CD8 cells. Cytotoxic T cell responses to a conserved epitope of P. falciparum liver stage antigen (LSA) type 1 are restricted by the HLA class I allele Bw53. The role of HLA class II alleles in mediating cellular responses against P. falciparum LSA-1 has not yet been demonstrated. In a longitudinal study performed for >4 years, associations were found between the HLA class II allele DQB1*0501 and protection from malaria anemia and malarial reinfections in Gabonese children. Children carrying DQB1*0501 had a higher frequency of interferon-gamma responses to LSA-1 T cell epitopes, compared with noncarriers.
May
J
J
Sekton Humanparasitologie, Institut für Tropenmedizin der Universität Tübingen, Germany. juergen.may@gmx.de
Lell
B
B
Luty
A J
AJ
Meyer
C G
CG
Kremsner
P G
PG
D000483:Alleles; D000740:Anemia / Q000209:etiology / Q000276:immunology*; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D000939:Epitopes / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000032:analysis; D016778:Malaria, Falciparum / Q000150:complications / Q000276:immunology*; D010455:Peptides / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D012008:Recurrence; D018417:Th1 Cells / Q000276:immunology*
D000953:Antigens, Protozoan; D000939:Epitopes; D006684:HLA-DR Antigens; D010455:Peptides; C067302:liver stage-specific antigen, Plasmodium; D007371:Interferon-gamma