Preliminary study of fresh juice of Benincasa hispida on morphine addiction in mice.
The juice of Benincasa hispida (BH) showed significant activity against symptoms of morphine withdrawal, such as jumping response and diarrhoea, in mice. These results seem to indicate that BH may prevent the development of morphine addiction and also suppress symptoms of opioid withdrawal in animals.
Grover
J K
JK
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India. jkgrover@hotmail.com
Rathi
S S
SS
Vats
V
V
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001628:Beverages; D002957:Citrus; D003967:Diarrhea / Q000517:prevention & control; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000037:antagonists & inhibitors*; D009021:Morphine Dependence / Q000517:prevention & control*; D009292:Narcotic Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
D009292:Narcotic Antagonists; D010936:Plant Extracts; D009020:Morphine