Multiple seizure susceptibility genes on chromosome 7 in SWXL-4 congenic mouse strains.
The SWXL-4 recombinant inbred mouse strain is unusually sensitive to recurrent tonic-clonic seizures upon routine handling and to seizures induced by chemoconvulsants. In a conventional intercross with the ABP/Le strain, we previously mapped a SWXL-4-derived quantitative trait locus called Szf1 (seizure frequency 1) to Chromosome 7. In the present study, we confirm the existence of Szf1 in both an independent cross and a congenic strain. However, derivative congenic recombinant strains show that an interaction between at least two genes on Chromosome 7-each of which has a very small effect on its own-account for Szf1.
Legare
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The Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Frankel
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D000818:Animals; D003433:Crosses, Genetic; D020022:Genetic Predisposition to Disease; D051379:Mice; D020297:Mice, Congenic; D008815:Mice, Inbred Strains; D019655:Quantitative Trait, Heritable; D012640:Seizures / Q000235:genetics*