18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies.
Using (18)F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with (18)F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.
Hu
X S
XS
Department of Geriatric Medicine, Tohoku University School of Medicine, and the Cyclotron and Radioisotope Center , Tohoku University, Sendai, Miyagi, Japan.
Okamura
N
N
Arai
H
H
Higuchi
M
M
Matsui
T
T
Tashiro
M
M
Shinkawa
M
M
Itoh
M
M
Ido
T
T
Sasaki
H
H
D000368:Aged; D000369:Aged, 80 and over; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008875:Middle Aged; D014055:Tomography, Emission-Computed
C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D004298:Dopamine