title: Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings.
abstract: OBJECTIVE
  To review, on a genome-wide scale, a linkage result obtained in an earlier candidate gene analysis in this same study sample, and to look for other possible contributing genetic loci predisposing to hypertension in this population.
  
  
  METHODS
  An affected sibpair linkage study with highly polymorphic genetic markers spanning the genome at an average intermarker density of 10 cM.
  
  
  METHODS
  A total of 47 families with two affected siblings (mostly dizygotic twins) and all available additional family members from the genetic isolate of Finland. The families were identified through the Finnish Twin Cohort Study, the total number of this follow-up cohort being 13,888. The study sample was selected on the basis of early-onset hypertension with minimal presence of other phenotypic risk factors such as obesity.
  
  
  RESULTS
  The AT1 locus stood out as the most significant locus in this population (maximum likelihood score 4.04). Some evidence for linkage was also detected with markers on chromosomes 2q (maximum likelihood score 2.96), 22q (2.07), and Xp (2.41).
  
  
  CONCLUSIONS
  Our results establish the role of the AT1 locus, on a genome-wide scale, as a major contributing locus to essential hypertension in this study sample.
authors.affiliation: National Public Health Institute, Department of Human Molecular Genetics, Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Perola
authors.forename: K
authors.initials: K
authors.lastname: Kainulainen
authors.forename: P
authors.initials: P
authors.lastname: Pajukanta
authors.forename: J D
authors.initials: JD
authors.lastname: Terwilliger
authors.forename: T
authors.initials: T
authors.lastname: Hiekkalinna
authors.forename: P
authors.initials: P
authors.lastname: Ellonen
authors.forename: J
authors.initials: J
authors.lastname: Kaprio
authors.forename: M
authors.initials: M
authors.lastname: Koskenvuo
authors.forename: K
authors.initials: K
authors.lastname: Kontula
authors.forename: L
authors.initials: L
authors.lastname: Peltonen
mesh_terms: D001794:Blood Pressure / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D015331:Cohort Studies; D005387:Finland; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000235:genetics; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin