Role of chemokines in thymocyte development.
As they mature, thymocytes migrate to specific regions of the thymus, interact with different types of stromal cells, and thereby receive signals for survival, differentiation, or death. Despite its importance, the molecular control of thymocyte trafficking remains poorly understood. Chemokines and their receptors probably control the homing of T cell progenitors to the thymus, their intrathymic migration, and exit to the periphery. Certain chemokines are abundant in the thymus, and their receptors are expressed during distinct developmental stages. Below, we discuss recent studies of chemokines and their receptors in the thymus, speculating on their function in the frame work of thymocyte trafficking.
Norment
A M
AM
Department of Immunology, University of Washington, Seattle 98195, USA.
Bevan
M J
MJ
D002450:Cell Communication; D002454:Cell Differentiation; D002465:Cell Movement; D018925:Chemokines / Q000494:pharmacology*; D004847:Epithelial Cells; D006412:Hematopoietic Stem Cells / Q000166:cytology; D019707:Receptors, Chemokine / Q000378:metabolism; D017154:Stromal Cells; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology*
D018925:Chemokines; D019707:Receptors, Chemokine