Patients with fibromyalgia have normal serum levels of hyaluronic acid.
OBJECTIVE
To investigate the levels of hyaluronic acid (HA) in Danish patients with fibromyalgia (FM).


METHODS
Serum levels of HA were determined in 53 patients with established FM and 55 control samples using a radiometric assay. Values were correlated to clinical disease severity variables (duration of disease, tender point scales, visual analog scales).


RESULTS
There were no differences in HA levels between patients and controls. HA levels of all patients except one were within the reference ranges. There was no association between HA levels and clinical findings.


CONCLUSIONS
Patients with FM do not generally have increased serum levels of HA.
Bliddal
H
H
Department of Rheumatology, Frederiksberg Hospital, Copenhagen, Denmark. henning.bliddal@fh.hosp.dk
Møller
H J
HJ
Schaadt
M
M
Danneskiold-Samsøe
B
B
D000375:Aging / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000097:blood; D005260:Female; D005356:Fibromyalgia / Q000097:blood*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values
D006820:Hyaluronic Acid