Use of intravenous valproate sodium in status migraine.
Patients with migraines have typically been given one group of medications for abortive treatment and another for preventative. In the acute situation when the patient has severe nausea it is difficult to administer medications. Intravenous medications would avoid this problem but are limited to the opiates and dihydroergotamine. The following cases demonstrate the acute treatment of migraine with intravenous valproic acid (Depacon). The oral form of valproic acid has been used as a prophylactic agent, but the intravenous form may provide an alternative for abortive care as well. The ease of administration and lack of side effects are also important considerations. Double-blind studies will help clarify the situation.
Norton
J
J
Department of Psychiatry, University of Mississippi College of Medicine, Jackson 39216, USA.
D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008881:Migraine Disorders / Q000150:complications / Q000188:drug therapy*; D009325:Nausea / Q000209:etiology; D010148:Intractable Pain / Q000188:drug therapy*; D014635:Valproic Acid / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D014839:Vomiting / Q000209:etiology
D014635:Valproic Acid