title: Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation.
abstract: Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 microg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.
authors.affiliation: Natural Products Research Institute, Seoul National University, Jongro-gu, Korea.
authors.forename: S S
authors.initials: SS
authors.lastname: Lim
authors.forename: S H
authors.initials: SH
authors.lastname: Jung
authors.forename: J
authors.initials: J
authors.lastname: Ji
authors.forename: K H
authors.initials: KH
authors.lastname: Shin
authors.forename: S R
authors.initials: SR
authors.lastname: Keum
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004791:Enzyme Inhibitors; D010975:Platelet Aggregation Inhibitors; D002599:Chalcone; D000449:Aldehyde Reductase