title: Neutrophilic leucocytosis in a dog with a rectal tumour.
abstract: A nine-year-old cocker spaniel was presented with a three-year history of intermittent haematochezia and a palpable rectal mass. Routine haematological examination revealed a marked mature neutrophilia (86.04 x 10(9) neutrophils/litre). A friable mass in the middle portion of the rectum was detected on colonoscopy. Histopathological examination of mucosal pinch biopsies collected from the mass confirmed a diagnosis of adenomatous tubulopapillary polyp. Some evidence of malignant transformation was observed. Palliative treatment with piroxicam suppositories at a dose of 1.4 mg/kg administered rectally every third day was instituted. On re-evaluation, 47 days after starting medical therapy, the owner reported a significant reduction in haematochezia and tenesmus; however, frequency of defecation had remained unaltered. Routine haematology revealed a reduction in the mature neutrophil count (33.67 x 10(9) neutrophils/litre). This report describes a case of a rectal tumour associated with a neutrophilic leucocytosis, which responded to palliative therapy with piroxicam suppositories.
authors.affiliation: Department of Veterinary Clinical Studies, Royal School of Veterinary Studies, Easter Bush Veterinary Centre, Roslin, Midlothian.
authors.forename: C M
authors.initials: CM
authors.lastname: Knottenbelt
authors.forename: J W
authors.initials: JW
authors.lastname: Simpson
authors.forename: M L
authors.initials: ML
authors.lastname: Chandler
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D000285:Administration, Rectal; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D004285:Dogs; D007955:Leukemoid Reaction / Q000209:etiology / Q000662:veterinary*; D008297:Male; D010894:Piroxicam / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D013488:Suppositories
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013488:Suppositories; D010894:Piroxicam