title: Effect of Mao-bushi-saishin-to on infection of ofloxacin resistant bacteria and of unknown origin.
abstract: When seven elderly patients with fever due to bacterial infection failed to respond to ofloxacin 300 mg/day for 3 days, we prescribed Mao-bushi-saishin-to for 7 days. Bushi, one of the components of Mao-bushi-saishin-to, is a complex of various alkaloids, which is known to stimulate the conducting system of the heart, so half of the standard dose was prescribed for these patients. We assessed changes in the patients' body temperatures and serum C-reactive protein concentrations. As a result, the patients' body temperatures all fell to under 37 degrees C and C-reactive protein levels decreased from an average of 3.06 mg/dl to an average of 0.36 mg/dl (P< 0.02). In cases where a fever does not decrease through dosage of an antibiotic such as ofloxacin after about 3 days, half of the standard dose of Mao-bushi-saishin-to for 7 days should be considered as a complementary therapy.
authors.affiliation: Shimane Institute of Health Science, Enya-cho, Izumo, Japan. kamei@nanken.shimane-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kamei
authors.forename: Y
authors.initials: Y
authors.lastname: Toriumi
authors.forename: H
authors.initials: H
authors.lastname: Tomioka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D001831:Body Temperature / Q000187:drug effects; D002097:C-Reactive Protein / Q000187:drug effects; D004352:Drug Resistance, Microbial; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000188:drug therapy; D006801:Humans; D015242:Ofloxacin; D012141:Respiratory Tract Infections / Q000188:drug therapy; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; C119422:mao-bushi-saishin-to; D002097:C-Reactive Protein; D015242:Ofloxacin