title: Preparation of (188Re) Re-AEDP and its biodistribution studies.
abstract: The synthesis of the Re (V) complex and preparation of 188Re-AEDP are described using 188Re which was obtained from the alumina-based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-AEDP on reducing agent concentration, AEDP concentration, pH and addition of carrier was examined. In the case of optimum conditions, the radiolabeling yields of 188Re-AEDP were 92-93% for carrier-free 188Re and 95-98% for carrier-added 188Re. The stability of 188Re-AEDP at pH approximately 6 was studied and it is found that the carrier has a significant effect on the stability of 188Re-AEDP. The biodistribution of carrier-free and carrier-added 188Re-labelled compounds in rats was also measured. The results show that 188Re (carrier-added)-AEDP is a potential bone palliation radiopharmaceutical due to its high skeletal uptake, rapid blood clearance and relatively low soft tissue absorption.
authors.affiliation: Shanghai Institute of Nuclear Research, The Chinese Academy of Sciences, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Qingnuan
authors.forename: Z
authors.initials: Z
authors.lastname: Xiaodong
authors.forename: S
authors.initials: S
authors.lastname: Rong
authors.forename: L
authors.initials: L
authors.lastname: Wenxin
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary; D004164:Diphosphonates / Q000302:isolation & purification* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004337:Drug Carriers; D004355:Drug Stability; D005260:Female; D006863:Hydrogen-Ion Concentration; D010166:Palliative Care; D019275:Radiopharmaceuticals / Q000302:isolation & purification* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D051381:Rats; D012211:Rhenium / Q000302:isolation & purification* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017971:Tin Compounds; D014018:Tissue Distribution
chemical_list: C417558:1-aminoethylene diphosphonic acid; D004164:Diphosphonates; D004337:Drug Carriers; D019275:Radiopharmaceuticals; D017971:Tin Compounds; C023599:stannous chloride; D012211:Rhenium