title: [Adjuvant antibiotic therapy as a 2-step treatment concept in early-onset periodontitis: a strategy for eradication of bacteria that cause periodontitis].
abstract: OBJECTIVE
  The periodontal region is a source of gram-negative bacterial infection. The pathogens involved have recently also been demonstrated in atheromatous plaques. They may increase the risk of myocardial infarction. In this study a strategy for eradicating periodontal bacteria and thus healing in patients with periodontal pockets and advanced destruction of alveolar bone was examined.
  
  
  METHODS
  Initial periodontal status was documented in 36 patients with periodontitis (24 women, 12 men) who were then randomly assigned to one of three groups. Those in two of the groups were given either metronidazole or doxycycline orally as adjuvant treatment, while the third group received no antibiotics. Patients in all groups were treated according to a two-step procedure. In step 1, extensive supra- and subgingival plaques and concrements were removed. In step 2, root debridement and/or closed curettage of all pockets was undertaken in one visit, and the antibiotic given to the patients in groups 1 and 2. Results were assessed 3 weeks after the first step and 6 months, 2 and 4 years after step 2.
  
  
  RESULTS
  The initial examination at 3 weeks revealed significant changes in all three groups with regard to the incidence of plaque and sulcus bleeding, but not regarding probing depth and attachment level. However, there were significant changes in probing depth and attachment level in all groups after step 2. Periodontal attachment was significantly improved at 2 and 4 years in the patients on metronidazole, but not those on doxycycline or no antibiotics. The greatest decrease in bleeding tendency was recorded in the metronidazole group. This group also had the greatest gain of new alveolar bone compared with the other two groups. Complete eradication of Porphyromonas gingivalis and Actinobacillus (Hemophilus) actinomycetemcomitans, important pathogenic bacteria that may have an atherogenic action, was obtained only in patients on metronidazole.
  
  
  CONCLUSIONS
  The tissue-sparing two-step procedure brought about good clinical and radiological results, which can be significantly bettered by the addition of metronidazole, achieving eradication of pathogens involved in periodontal disease.
authors.affiliation: Poliklinik für Konservierende Zahnheilkunde, Friedrich-Schiller-Universität Jena. bernd.w.sigusch@med.uni-jena.de
authors.forename: B
authors.initials: B
authors.lastname: Sigusch
authors.forename: W
authors.initials: W
authors.lastname: Pfister
authors.forename: G
authors.initials: G
authors.lastname: Klinger
authors.forename: E
authors.initials: E
authors.lastname: Glockmann
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000628:therapy; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D017024:Chemotherapy, Adjuvant; D003475:Curettage; D003627:Data Interpretation, Statistical; D003646:Debridement; D003773:Dental Plaque / Q000628:therapy; D004318:Doxycycline / Q000008:administration & dosage; D005260:Female; D005491:Focal Infection, Dental / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D010514:Periodontal Pocket / Q000188:drug therapy / Q000628:therapy; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy*; D010519:Periodontium / Q000382:microbiology*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D004318:Doxycycline