Glutathione S-transferase pi gene methylation: the search for a molecular marker of prostatic adenocarcinoma.
Glutathione S-transferase pi gene methylation has recently been described in prostatic adenocarcinoma. Aggregate data on 115 samples studied to date have found an 87% sensitivity and 92% specificity for prostate cancer diagnosis. The current literature about this new marker is herein summarized, and possible molecular mechanisms by which glutathione S-transferase pi may participate in prostatic carcinogenesis are reviewed. The possible clinical implications of this molecular alteration in the diagnosis of prostatic adenocarcinoma are also studied.
Jimenez
R E
RE
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Fischer
A H
AH
Petros
J A
JA
Amin
M B
MB
D000230:Adenocarcinoma / Q000201:enzymology*; D000483:Alleles; D019175:DNA Methylation; D005819:Genetic Markers; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D008297:Male; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000201:enzymology*
D005819:Genetic Markers; D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase