Synthesis of the potent antimalarials calothrixin A and B.
A concise synthesis of calothrixins A (1) and B (2) that confirms their assigned structures and affords straightforward synthetic access to them is reported.
Kelly
T R
TR
E. F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachussets 02467, USA. ross.kelly@bc.edu
Zhao
Y
Y
Cavero
M
M
Torneiro
M
M
D000962:Antimalarials / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D026121:Indole Alkaloids; D007211:Indoles / Q000138:chemical synthesis*
D000962:Antimalarials; D026121:Indole Alkaloids; D007211:Indoles; C418328:calothrixin A; C418327:calothrixin B