Experimental infection model for Taenia solium cysticercosis in swine. Cysticercosis Working Group in Peru.
A novel method for infecting pigs with Taenia solium using an intramuscular innoculum of oncospheres was investigated in a series of five experiments in 18 animals. The model is simple to perform, requires a minimal number of oncospheres, permits multiple infections per animal, and decreases the variation inherent in oral infection models. This intramuscular oncosphere assay (IMOA) may provide a valuable tool to evaluate therapeutic agents or potential vaccines for cysticercosis.
Verástegui
M
M
Department of Pathology and Department of Microbiology, Universidad Peruana Cayetano Heredia, PO Box 5045, Lima, Peru.
González
A
A
Gilman
R H
RH
Gavidia
C
C
Falcón
N
N
Bernal
T
T
Garcia
H H
HH
D000284:Administration, Oral; D000818:Animals; D003551:Cysticercosis / Q000469:parasitology / Q000662:veterinary*; D003552:Cysticercus / Q000472:pathogenicity*; D004195:Disease Models, Animal; D006651:Histocytochemistry; D007273:Injections, Intramuscular / Q000662:veterinary; D007274:Injections, Intraperitoneal / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology*