Intravenous immunoglobulin treatment in peripheral nerve disorders--indications, mechanisms of action and side-effects.
This review summarizes observations of clinical use of high dose intravenous immunoglobulin G (IVIg) in regards to administration, kinetics, known or postulated mechanisms of action, and adverse reactions. Indications and value of IVIg for the treatment of various neuropathies with presumed autoimmune aetiology are examined. New knowledge that advances the understanding of the pathogenesis of the neuropathies and of the mechanisms of action of IVIg is discussed.
Hahn
A F
AF
London Health Sciences Centre, The University of Western Ontario, Canada. angelika.hahn@lhsc.on.ca
D001327:Autoimmune Diseases / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D010257:Paraneoplastic Syndromes / Q000188:drug therapy; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000188:drug therapy; D012307:Risk Factors
D016756:Immunoglobulins, Intravenous