title: Alkali- and heat-treated porous titanium for orthopedic implants.
abstract: This study was carried out to investigate the effects of the alkali and heat treatments on the bone-bonding behavior of porous titanium implants. Porous titanium implants had a 4.6 mm solid core and a 0.7 mm thick porous outer layer using pure titanium plasma-spray technique. Three types of porous implants were prepared from these pieces: 1.control implant (CL implant) as manufactured 2.AW-glass ceramic bottom-coated implant (AW implant) in which AW-glass ceramic was coated on only the bottom of the pore of the implant 3.alkali- and heat-treated implant (AH implant), where implants were immersed in 5 mol/L NaOH solution at 60 degrees C for 24 h and subsequently heated at 600 degrees C for 1 h. The implants were inserted into bilateral femora of six dogs hemi-transcortically in a randomized manner. At 4 weeks, push-out tests revealed that the mean shear strengths of the CL, AW, and AH implants were about 10.8, 12.7, and 15.0 MPa, respectively. At 12 weeks there was no significant difference between the bonding strengths of the three types of the porous implants (16.0-16.7 MPa). Histologically and histomorphologically, direct bone contact with the implant surface was significantly higher in the AH implants than the CL and AW implants both at 4 and 12 weeks. Thus, the higher bonding strength between bone and alkali- and heat-treated titanium implants was attributed to the direct bonding between bone and titanium surface. In conclusion, alkali and heat treatments can provide porous titanium implants with earlier stable fixation.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Shougoin-kawaharacho 54, Sakyo-ku, Kyoto 606-8507, Japan. Nishiguchi@ma4.seikyou.ne.jp
authors.forename: S
authors.initials: S
authors.lastname: Nishiguchi
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Neo
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Kokubo
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D002516:Ceramics; D020099:Coated Materials, Biocompatible; D004285:Dogs; D005269:Femur; D005898:Glass; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010012:Osteogenesis; D016062:Porosity; D019919:Prosthesis Implantation; D013499:Surface Properties; D014025:Titanium
chemical_list: D018786:Bone Substitutes; D020099:Coated Materials, Biocompatible; D014025:Titanium