title: The effect of a high-fat diet and exercise on the expression of genetic obesity.
abstract: In the United States, there are 300,000 obesity-related premature deaths each year. Furthermore, no current obesity treatment program results in consistent weight reductions. Obesity is thought to be caused by complex genetic-environmental interactions. We studied the effect of two environmental factors, high-fat diet and non-weight-bearing exercise, on obesity expression. Young adult, female, genetically obese (fa/fa) rats (n = 52) and their lean (Fa/fa) littermates (n = 24) were studied using an experimental 2 x 2 x 2 factorial design (diet type, genetics, and exercise). Repeated measures ANOVA and secondarily stepwise regressions were used to analyze the data. The authors discovered that the effect of appetite on obesity expression is more limited than expected, and there may be critical stages when obesity expression is amenable to environmental modification.
authors.affiliation: University of Michigan, School of Nursing, USA.
authors.forename: B L
authors.initials: BL
authors.lastname: Metzger
authors.forename: P A
authors.initials: PA
authors.lastname: Jarosz
authors.forename: S
authors.initials: S
authors.lastname: Noureddine
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001066:Appetite; D001823:Body Composition; D004041:Dietary Fats; D004195:Disease Models, Animal; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D009765:Obesity / Q000209:etiology* / Q000235:genetics* / Q000473:pathology / Q000517:prevention & control; D010805:Physical Conditioning, Animal; D051381:Rats; D011924:Rats, Zucker; D012044:Regression Analysis
chemical_list: D004041:Dietary Fats