title: [The time factor in oncology: does the overall treatment time in chemotherapy have a role?].
abstract: BACKGROUND
  The treatment of malignant tumors consists in the optimal combination of the 4 modalities surgery, radiotherapy, chemotherapy, and immunotherapy. An important goal of clinical research is the development of the optimal application of each of these modalities.
  
  
  METHODS
  This review of the literature focuses on the importance of the total treatment duration and dose intensity in the development of chemotherapy regimens. Three important malignant diseases will be examined as to the optimal application of systemic chemotherapy.
  
  
  CONCLUSIONS
  Tumor models with the resulting hypotheses and well-designed clinical trials will lead to progress in the treatment of malignant tumors.
authors.affiliation: Innere Medizin I, Universitätskliniken des Saarlandes, Homburg/Saar. inltru@med-rz.uni-sb.de
authors.forename: L
authors.initials: L
authors.lastname: Trümper
authors.forename: M
authors.initials: M
authors.lastname: Pfreundschuh
mesh_terms: D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D013997:Time Factors