Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
The novel analogues of natural cdc25A inhibitor dysidiolide were synthesized. To investigate the structure-activity relationship, the inhibitory activity to enzyme and cell cycle was examined.
Takahashi
M
M
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
Dodo
K
K
Sugimoto
Y
Y
Aoyagi
Y
Y
Yamada
Y
Y
Hashimoto
Y
Y
Shirai
R
R
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D020687:cdc25 Phosphatases; C121906:dysidiolide; D015107:4-Butyrolactone