Assessment of optic disk blood flow in patients with open-angle glaucoma.
OBJECTIVE
To characterize optic disk blood flow in patients with open-angle glaucoma compared with age-matched healthy control subjects.


METHODS
In this prospective cross-sectional study, 90 eyes of 90 patients with open-angle glaucoma and 61 eyes of 61 age-matched healthy control subjects were evaluated. Flow in the optic disk cup and the neuroretinal rim were assessed with scanning laser Doppler flowmetry. Fundus pulsation amplitude in the cup and the macula were assessed with laser interferometry. Visual field mean deviation was measured with the Humphrey 30 to 2 program.


RESULTS
Flow in the neuroretinal rim (-18%, P =.002), and in the cup (-46%, P <.001) and fundus pulsation amplitude in the cup (-33%, P <.001) and in the macula (-24%, P <.001) were significantly lower in patients with open-angle glaucoma compared with healthy control subjects. A significant association between blood flow measurements in the cup and fundus pulsation amplitudes in the cup was observed in both study cohorts. A significant association was also observed between the mean defect from visual field testing and ocular hemodynamic parameters.


CONCLUSIONS
Reduced optic disk perfusion in patients with open-angle glaucoma is evidenced from two independent methods in the present study. Moreover, our data indicate that reduced ocular blood flow in these patients is linked to visual field changes. It remains to be established whether compromised optic disk and choroidal blood flow contributes to optic disk damage in glaucomatous eyes or is a secondary functional phenomenon.
Findl
O
O
Department of Clinical Pharmacology, Währinger Gürtel, Vienna, Austria.
Rainer
G
G
Dallinger
S
S
Dorner
G
G
Polak
K
K
Kiss
B
B
Georgopoulos
M
M
Vass
C
C
Schmetterer
L
L
D000368:Aged; D001783:Blood Flow Velocity; D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007368:Interferometry; D007429:Intraocular Pressure; D017078:Laser-Doppler Flowmetry; D007834:Lasers; D008297:Male; D009898:Optic Disk / Q000098:blood supply* / Q000503:physiopathology; D011446:Prospective Studies; D014792:Visual Acuity; D014794:Visual Fields