Determinants of plasma total homocysteine levels in Korean chronic renal transplant recipients.
OBJECTIVE
Study the determinants of plasma total homocysteine (tHcy) levels, such as fasting levels of serum creatinine (SCr), albumin, plasma tHcy, folate, B(12), and pyridoxal-5'-phosphate (PLP) in chronic Korean renal transplant recipients (RTR).


METHODS
Cross-sectional study.


METHODS
Nephrology & Transplant Service in Catholic University Kangnam St. Mary's Hospital, Seoul, Korea.


METHODS
Ninety-one chronic Korean RTR with stable renal function who were > or =6 months post-transplant.


METHODS
Used medical record review and anthropometric measurements, and overnight (10 to 14 hours) fasting blood samples were measured for plasma tHcy, PLP, folate, B(12), SCr, and albumin.


RESULTS
The prevalence of hyperhomocysteinemia (tHcy > 12 micromol/L) was 56%, and 47% had low plasma folate levels (<3 ng/mL). Linear modeling with analysis of covariance adjusted for age, sex, albumin, SCr, and plasma B-vitamin status revealed that only SCr (standard regression coefficient R = +0.663, P<.001), plasma folate (R = -0.276, P =.001), and B(12) (R = -0.149, marginal, P =.08) were independent determinants of fasting tHcy levels in this patient population.


CONCLUSIONS
Renal function is the major independent determinant of the fasting tHcy levels among chronic, stable Korean RTR, and that B-vitamin status plays a secondary role among such patients.
Han
H
H
Frances Stern Nutrition Center, New England Medical Center and Tufts University School of Nutrition Science and Policy, Boston, MA 02111, USA.
Dwyer
J T
JT
Selhub
J
J
Jacques
P F
PF
Park
J H
JH
Kim
Y S
YS
Bang
B K
BK
Bostom
A G
AG
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000150:complications; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D003430:Cross-Sectional Studies; D005215:Fasting; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000378:metabolism; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000601:surgery; D016030:Kidney Transplantation; D007723:Korea; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011732:Pyridoxal Phosphate / Q000097:blood; D012709:Serum Albumin / Q000032:analysis; D014805:Vitamin B 12 / Q000097:blood / Q000378:metabolism
D012709:Serum Albumin; D006710:Homocysteine; D011732:Pyridoxal Phosphate; D005492:Folic Acid; D003404:Creatinine; D014805:Vitamin B 12