Novelties in the field of anti-infective compounds in 1999.
In 1999 the number of new compounds reported in the anti-infective field decreased significantly in comparison with previous years, especially for antifungals. The reported new compounds are mainly directed against Staphylococcus aureus isolates resistant to methicillin. Few derivatives were reported in the field of anti-infectives for gram-negative bacteria. At the moment, we are in a period of discovery as we await novel compounds that could issue from new engineering.
Bryskier
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Aventis Pharma, Infectious Disease Group, Romainville, France. andre.bryskier@aventis.com
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D015507:Drugs, Investigational / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D056890:Eukaryota / Q000187:drug effects; D006801:Humans; D007239:Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D015507:Drugs, Investigational