Comparison of the anti-Ro/SSA autoantibody profile between patients with primary and secondary Sjögren's syndrome.
OBJECTIVE
To measure serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies in patients with primary and secondary Sjögren's syndrome. To examine if there is any connection between the disease and the subtype-spectrum of these antibodies.


METHODS
We measured serum levels of anti-Ro52-kD/SSA, anti-Ro60-kD/SSA and anti-La/SSB autoantibodies by ELISA, in the sera of patients with primary Sjögren's syndrome with or without extraglandular manifestations and with or without anti-La/SSB positivity and of patients with systemic lupus erythematosus/Sjögren's syndrome overlapping disease with or without anti-La/SSB positivity.


RESULTS
Differences of the distribution of the anti-Ro52-kD/SSA and the anti-Ro60-kD/SSA were found between the primary and secondary Sjögren's syndrome patients' groups; when Sjögren's syndrome is accompanied by systemic lupus erythematosus, the occurrence of anti-Ro60-kD/SSA autoantibodies is significantly higher than in primary Sjögren'syndrome.


CONCLUSIONS
Our results suggest that there is a possible connection between the distribution of the subtypes of the anti-Ro/SSA autoantibodies and the disease type in primary/secondary Sjögren's syndrome.
Gál
I
I
3rd Department of Internal Medicine and Clinical Immunology, Medical University School of Debrecen Debrecen, Móricz, Hungary.
Lakos
G
G
Zeher
M
M
D000974:Antibodies, Antinuclear / Q000097:blood*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology; D012859:Sjogren's Syndrome / Q000145:classification / Q000150:complications / Q000276:immunology*
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; C035357:SS-B antibodies