title: Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities.
abstract: Two new cardenolides, (-)-14-hydroxy-3beta-(3-O-methyl-6-deoxy-alpha-L-rhamnosyl)-11a lpha, 12alpha-epoxy-(5beta,14beta,17betaH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3beta-(3-O-methyl-6-deoxy-alpha-L-glucopyranosyl)-11al pha,12alpha-epoxy-(5beta,14beta,17betaH)-card -20(22)-enolide (2), and a known cardenolide, (-)-17beta-neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and antiestrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Chang
authors.forename: J J
authors.initials: JJ
authors.lastname: Gills
authors.forename: K P
authors.initials: KP
authors.lastname: Bhat
authors.forename: L
authors.initials: L
authors.lastname: Luyengi
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002298:Cardenolides / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D020847:Estrogen Receptor Modulators / Q000302:isolation & purification* / Q000494:pharmacology; D005434:Flow Cytometry; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D014197:Trees; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D020847:Estrogen Receptor Modulators