title: Drug toxicity in E. coli cells expressing human topoisomerase I.
authors.affiliation: Department of Microbial Molecular Biology, Bristol-Meyers-Squibb, Princeton, NJ, USA.
authors.forename: S T
authors.initials: ST
authors.lastname: Taylor
authors.forename: R
authors.initials: R
authors.lastname: Menzel
mesh_terms: D000362:Agar; D000970:Antineoplastic Agents / Q000494:pharmacology; D002166:Camptothecin / Q000494:pharmacology; D002463:Cell Membrane Permeability; D004249:DNA Damage / Q000187:drug effects; D004264:DNA Topoisomerases, Type I / Q000235:genetics / Q000378:metabolism*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics* / Q000254:growth & development; D005615:Freezing; D017930:Genes, Reporter; D006801:Humans; D007544:Isopropyl Thiogalactoside / Q000494:pharmacology; D009154:Mutation; D009268:Nalidixic Acid / Q000378:metabolism; D010957:Plasmids / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D059004:Topoisomerase I Inhibitors; D001616:beta-Galactosidase / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D011994:Recombinant Proteins; D059004:Topoisomerase I Inhibitors; D007544:Isopropyl Thiogalactoside; D009268:Nalidixic Acid; D000362:Agar; D001616:beta-Galactosidase; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin