Micronucleus formation induced by the combination of low doses of X-rays and antineoplastic drugs in bone marrow of male mice.
People are widely exposed during their lifetime to many biological, chemical, and physical agents in the environment and at work. In this paper the effects of combined exposures of nonmutagenic doses of X-rays and anticancer agents (cyclophosphamide, mitomycin C, and vinblastine) have been investigated on the induction of micronuclei in the bone marrow of laboratory mice. The combination of X-rays and anticancer drugs enhanced the frequency of micronuclei in some cases. The strongest effects were found after the combination of X-rays and cyclophosphamide at 24 h and 72 h. The combined treatment of X-rays and mitomycin C enhanced the mutagenic effect at 72 h. The combination of X-rays + vinblastine slightly potentiated the mutagenic effect at 24 h and 48 h.
Dobrzyńska
M M
MM
Department of Radiation Protection and Radiobiology, National Institute of Hygiene, Poland. mdobrzynska@pzh.gov.pl
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D016685:Mitomycin / Q000008:administration & dosage / Q000633:toxicity; D014747:Vinblastine / Q000008:administration & dosage / Q000633:toxicity
D000970:Antineoplastic Agents; D016685:Mitomycin; D014747:Vinblastine; D003520:Cyclophosphamide