Optimization of parameters for the analysis of aromatic amines in finger-paints.
A study for the optimisation of the supercritical fluid extraction (SFE) of some aromatic amines (4-chloro-o-toluidine, 2-naphthylamine, 4-aminobiphenyl and benzidine) in finger-paints was conducted. The influence of different variables related to the technique on recoveries was investigated. The analytes were subsequently analysed by gas chromatography after SFE. The study allowed the estimation of four main factors (temperature, pressure, static time and volume of modifier) on recoveries by the use of a two-level factor design, where most significant parameters as well as second- and third-order interactions were identified. Other factors, such as type and volume of modifier and time of contact between the spiker solution and the sample prior to extraction, were also studied. The influence of matrix on extraction recovery was also evaluated by applying the method to different finger-paints, and recoveries were similar or even higher in some cases. The drying process of samples was also studied, while classical drying in an oven and microwaves were compared, with similar efficiencies in both methods. The method was validated by extracting the aromatic amines from some commercial finger-paints.
Garrigós
M C
MC
Analytical Chemistry Department, University of Alicante, Spain.
Reche
F
F
Pernías
K
K
Jiménez
A
A
D000588:Amines / Q000032:analysis*; D002845:Chromatography / Q000379:methods; D010150:Paint / Q000032:analysis*
D000588:Amines