Experimental studies concerning the possible involvement of adenosine in maintaining the hydroelectrolytic balance.
The study focused on the effects of intracerebroventricular (i.c.v.) administration of adenosine (10(-7)-10(-5) M) on water metabolism and some electrolytes in adults rats. The i.c.v. administered adenosine decreases both spontaneous and angiotensin II (Ang II) induced ingestion of sodium chloride solution (9/1000). Urinary release was differently influenced. Thus, while the released urinary volume increased in the first 4 hours after adenosine injection, it was not significantly modified on successive administration of adenosine and Ang II. Adenosine decreases the urinary releases of Na+ and K+ and dramatically reduces only Ang II-induced natriuresis. Finally, we can conclude that neural chains involved in the control of uptake and release of water and some ions, include neurons and/or purinergic interneurons.
Slătinean
S M
SM
Medicine Faculty, Physiology Chair, Gr. T. Popa University of Medicine and Pharmacy, Iaşi.
Costuleanu
M
M
Mândreci
I
I
Petrescu
G
G
D000241:Adenosine / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001834:Body Water / Q000378:metabolism*; D004231:Diuresis / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004573:Electrolytes / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride
D004573:Electrolytes; D000804:Angiotensin II; D012965:Sodium Chloride; D000241:Adenosine; D011188:Potassium