title: [Details and indications of pallidotomy and thalamotomy for Parkinson's disease].
abstract: Pallidotomy has recently regained acceptance as an effective treatment for Parkinson's disease. From our 50 cases of unilateral pallidotomy and 10 cases of staged bilateral pallidotomy, details and indications of the procedure is described. The unilateral pallidotomy is quite effective for L-dopa induced dyskinesia, which usually completely disappears soon after the operation. The effect is long-lasting. When on-off phenomenon exists, unilateral pallidotomy improves off-stage rigidity or akinesia. Symptoms during on-stage are not changed. Indications of pallidotomy is that(1) L-dopa induced dyskinesia, and(2) on-off phenomenon. Bilateral pallidotomy, even by staged one, causes severe drooling, or speech disturbance(the volume of the voice decreases and the articulation worsens), and is not recommended. Vim thalamotomy is, on the other hand, the established treatment for tremor of Parkinson's disease or of essential tremor. The effect is long-lasting. Rigidity or akinesia is not expected to be improved so much.
authors.affiliation: Department of Neurosurgery, Kyoto Kizugawa Hospital.
authors.forename: J
authors.initials: J
authors.lastname: Takeuchi
authors.forename: T
authors.initials: T
authors.lastname: Yamagami
authors.forename: H
authors.initials: H
authors.lastname: Saiki
mesh_terms: D004409:Dyskinesia, Drug-Induced / Q000601:surgery; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D009127:Muscle Rigidity / Q000209:etiology / Q000601:surgery; D010300:Parkinson Disease / Q000150:complications / Q000601:surgery*; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000601:surgery*; D014202:Tremor / Q000209:etiology / Q000601:surgery
chemical_list: D007980:Levodopa