[Interaction of serotonin and nitric oxide (NO) in activation of the serotoninergic system in Helix].
Serotonin and the NO donors were shown to induce excitation in all serotoninergic neurones under study and to activate synchronous synaptic input in the Helix brain. The serotonin effects may be blocked by 5,7-DOT and N-monomethyl-L-arginine. The 5,7-DOT blocked activation of the NO-induced synchronous bursts but did not affect their activating effect. The data obtained suggest that serotonin and NO equally regulate the serotoninergic system's function in the snail brain. The effects of serotonin and NO are interconnected and interdependent. A possible role of the NO as a second messenger during serotonin activation and as a serotonin co-transmitter in presynaptic neurones, is discussed.
D'iakonova
T L
TL
Kotzov Institute of Developmental Biology, Russian Acad. Sci., Moscow, Russia.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D017952:Ganglia, Invertebrate / Q000378:metabolism / Q000502:physiology; D006372:Helix, Snails; D008564:Membrane Potentials; D008839:Microelectrodes; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D012701:Serotonin / Q000502:physiology*; D018490:Serotonin Agents / Q000494:pharmacology; D013569:Synapses / Q000502:physiology; D019323:omega-N-Methylarginine / Q000494:pharmacology
D004791:Enzyme Inhibitors; D020030:Nitric Oxide Donors; D018490:Serotonin Agents; D019323:omega-N-Methylarginine; D015116:5,7-Dihydroxytryptamine; D009569:Nitric Oxide; D012701:Serotonin