[For which tumor entities are effects of overall treatment time on the results of radiotherapy evident?].
METHODS
The effect of overall treatment time on therapeutic outcome was analyzed comparing the randomized trials on accelerated fractionation for the different tumor entities. Only studies using radiotherapy as the definitive locoregional treatment modality were included.


CONCLUSIONS
Randomized studies were performed for squamous cell carcinomas of the head and neck region as well as for small-cell and non-small-cell carcinomas of the lung. These studies showed, that locoregional control can be improved by accelerated fractionation in comparison to conventional fractionation with the same total dose. With the same antitumor effectiveness of both fractionation schedules, total dose can be reduced using accelerated fractionation.
Stuschke
M
M
Strahlenklinik, Universitätsklinikum Essen. martin.stuschke@uni-essen.de
Marnitz
S
S
Wurm
R
R
Budach
V
V
D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000532:radiotherapy*; D018288:Carcinoma, Small Cell / Q000401:mortality / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D015201:Meta-Analysis as Topic; D008962:Models, Theoretical; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D011879:Radiotherapy Dosage; D016032:Randomized Controlled Trials as Topic; D013997:Time Factors