title: Malaria eradication on islands.
abstract: BACKGROUND
  To be successful, a malaria control programme needs to be tailored to the local epidemiological characteristics. Vanuatu consists of 80 inhabited islands in the Southwest Pacific, with hypoendemic and mesoendemic malaria and suitable conditions for sustained parasite elimination. We aimed to assess whether malaria can be eliminated on isolated islands.
  
  
  METHODS
  Weekly mass drug administration of chloroquine, pyrimethamine/sulfadoxine (Fansidar), and primaquine was carried out on the entire population of 718 inhabitants of Aneityum island for 9 weeks in 1991 before the onset of the rainy season. Simultaneously with the administration of drugs, permethrin-impregnated bednets were distributed to the entire population. Larvivorous fish were also introduced into several identified breeding sites of Anopheles farauti. Periodic malariometric monitoring has continued for the past 9 years. Two additional islands of Vanuatu, one with and one without malaria transmission, have been monitored for comparison.
  
  
  RESULTS
  High community involvement as measured by drug compliance (88.3%) and bednet provision (0.94 nets per villager) has resulted in sustained interruption of malaria transmission in Aneityum. The surveys showed complete absence of Plasmodium falciparum after mass drug administration, and P. vivax disappeared from 1996 onwards, with the exception of two instances of imported infections (one mixed infection in 1993 and one P. vivax infection in 1999).
  
  
  CONCLUSIONS
  Malaria can be eliminated on isolated islands with well-adapted short-term mass drug administration and sustained vector control if there is a high degree of community participation.
authors.affiliation: Department of International Affairs and Tropical Medicine, Tokyo Women's Medical University School of Medicine, Japan. akirak@research.twmu.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Kaneko
authors.forename: G
authors.initials: G
authors.lastname: Taleo
authors.forename: M
authors.initials: M
authors.lastname: Kalkoa
authors.forename: S
authors.initials: S
authors.lastname: Yamar
authors.forename: T
authors.initials: T
authors.lastname: Kobayakawa
authors.forename: A
authors.initials: A
authors.lastname: Björkman
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D001512:Bedding and Linens; D002648:Child; D002675:Child, Preschool; D003256:Community Participation; D005399:Fishes; D006801:Humans; D007223:Infant; D008288:Malaria / Q000453:epidemiology / Q000517:prevention & control*; D009032:Mosquito Control / Q000379:methods*; D010139:Pacific Islands / Q000453:epidemiology; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D010966:Plasmodium vivax / Q000302:isolation & purification*; D015995:Prevalence; D013154:Spleen / Q000469:parasitology
chemical_list: D000962:Antimalarials