title: Cardiac involvement in patients with acute neurologic disease: confirmation with cardiac troponin I.
abstract: BACKGROUND
  Patients with acute neurologic illness often manifest findings suggestive of cardiac injury. Their proper interpretation is unclear. Accordingly, we conducted a blinded evaluation to assess the incidence of cardiac injury determined by elevations of cardiac troponin I (cTnI) in patients presenting within 24 hours of a neurologic event and to determine their short- and long-term prognostic effect.
  
  
  METHODS
  Blood samples for measurement of cTnI levels were obtained on hospital admission and daily for 3 days and were run by immunoassay. Extensive clinical evaluations including electrocardiograms and echocardiograms were obtained from all patients; daily follow-up evaluations were performed. The clinical electrocardiographic, echocardiographic, and biochemical data were analyzed independently by blinded observers.
  
  
  RESULTS
  Peak levels of cTnI were elevated (> or =0.4 microg/L) in 17 patients (19%) (mean + SD, 2.5 + 2.7 microg/L). All patients with elevated cTnI levels had clinical, electrocardiographic, or echocardiographic evidence of cardiac injury except those (n = 5) with minor elevations. One-year mortality was 29% (23/80). Early death (< or =30 days) accounted for 44% of total mortality (n = 10) and was significantly higher in patients with elevated cTnI levels (Wilcoxon P =.01; odds ratio, 6. 4). This difference was less marked by 1 year (Wilcoxon P =.07).
  
  
  CONCLUSIONS
  There is a substantial prevalence of myocardial injury in patients with acute neurologic illness. Cardiac injury in this population, as in others, seems to adversely affect prognosis.
authors.affiliation: Mayo Clinic, 200 First St SW, Mayo Clinic Building, 16th Floor, Rochester, MN 55905, USA.
authors.forename: S
authors.initials: S
authors.lastname: Dixit
authors.forename: M
authors.initials: M
authors.lastname: Castle
authors.forename: R P
authors.initials: RP
authors.lastname: Velu
authors.forename: L
authors.initials: L
authors.lastname: Swisher
authors.forename: C
authors.initials: C
authors.lastname: Hodge
authors.forename: A S
authors.initials: AS
authors.lastname: Jaffe
mesh_terms: D000208:Acute Disease; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood* / Q000150:complications*; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I