title: Synthesis and deprotection of oligonucleotides under aprotic conditions.
abstract: Oligonucleotides containing an alkali-labile nucleotide are synthesized and deprotected using a synthetic method that eliminates the use of Bronsted acid and base. The development of a new family of exocyclic amine-protecting groups is an integral component of this approach.
authors.affiliation: Department of Chemistry, Colorado State University, Ft. Collins, Colorado 80523, USA.
authors.forename: T
authors.initials: T
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Fu
authors.forename: M M
authors.initials: MM
authors.lastname: Greenberg
mesh_terms: D007202:Indicators and Reagents; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D007202:Indicators and Reagents; D009841:Oligonucleotides