title: Double-stranded nucleic acids in liquid-crystalline dispersions as building blocks for cross-linked supramolecular structures.
abstract: Double-stranded DNA fixed in a cholesteric liquid-crystalline dispersion was used for generating an ordered supramolecular structure in the presence of anthracycline and copper (II) ions. The structure is stable in a water-salt solution and does not require poly(ethyleneglycol).The ordered network can be immobilized on the surface of a polymeric film, and may collapse in the presence of biologically and pharmacologically relevant compounds. Accordingly, the DNA-based liquid-crystalline network represents the basis to obtain novel highly sensitive biosensing units.
authors.affiliation: VA Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow.
authors.forename: Y M
authors.initials: YM
authors.lastname: Yevdokimov
authors.forename: V I
authors.initials: VI
authors.lastname: Salyanov
authors.forename: B V
authors.initials: BV
authors.lastname: Mchedlischvili
authors.forename: V A
authors.initials: VA
authors.lastname: Bykov
authors.forename: A V
authors.initials: AV
authors.lastname: Belyaev
authors.forename: S A
authors.initials: SA
authors.lastname: Saunin
authors.forename: F
authors.initials: F
authors.lastname: Spener
authors.forename: M
authors.initials: M
authors.lastname: Palumbo
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002645:Chickens; D002942:Circular Dichroism; D003300:Copper / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D003460:Crystallization; D004247:DNA / Q000737:chemistry*; D003630:Daunorubicin / Q000737:chemistry; D046911:Macromolecular Substances; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D011092:Polyethylene Glycols / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D014867:Water
chemical_list: D001704:Biopolymers; D002412:Cations; D002614:Chelating Agents; D003432:Cross-Linking Reagents; D046911:Macromolecular Substances; D014867:Water; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D003300:Copper; D004247:DNA; D003630:Daunorubicin