Adhesion molecules and gene transfer.
Cell adhesion molecules are a large group of molecules involved in a variety of cell-to-cell and cell-to-extra-cellular matrix (ECM) interactions. Apart from their cellular function these molecules are exploited by a number of pathogenic micro-organisms as receptors for cell entry. Discovery of the use of adhesion molecules for binding and internalisation by naturally occurring pathogens has fuelled much research, in recent years, into the utilisation of these molecules for the targeting and uptake of both gene and drug delivery systems. This review describes the development of such systems and their potential advantages over other receptor-targeted delivery systems.
Parkes
R J
RJ
Molecular Immunology Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Hart
S L
SL
D000256:Adenoviridae / Q000235:genetics; D015820:Cadherins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism / Q000627:therapeutic use; D004705:Endocytosis; D004847:Epithelial Cells / Q000378:metabolism; D018014:Gene Transfer Techniques; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D016023:Integrins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy; D018919:Neovascularization, Physiologic / Q000235:genetics; D019151:Peptide Library; D019087:Selectins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D015398:Signal Transduction; D015011:Yersinia pseudotuberculosis / Q000235:genetics / Q000378:metabolism
D015820:Cadherins; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; D016023:Integrins; D019151:Peptide Library; D019087:Selectins