title: Loss of CD9 with Expression of CD31 and VEGF in Breast Carcinoma, as Predictive Factors of Lymph Node Metastasis.
abstract: Immunohistochemical staining for CD9, CD31 and vascular endothelial growth factor(VEGF)was performed in breast carcinoma specimens. CD9 was expressed in the membrane of carcinoma cells in 61 of 93 cases(67%), CD31 in the membrane of carcinoma cells in 23 of 86 cases(27%), and VEGF in the cytoplasm of carcinoma cellsin 26 of 86 cases(30%). The expression of CD9, CD31 and VEGF did not singly correlate with any clinicopathological factors. However, a loss of CD9 with concurrent expression of CD31 or VEGF in the invasive component showed a slight correlation with lymph node metastasis. These findings suggest that the potential for metastatic spread to lymph nodes in breast carcinoma may be synergically affectedby various factors.
authors.affiliation: Second Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
authors.initials: K
authors.lastname: Arihiro
authors.initials: M
authors.lastname: Kaneko
authors.initials: S
authors.lastname: Fujii
authors.initials: K
authors.lastname: Inai