title: Cytotoxic constituents of Polyalthia longifolia var. pendula.
abstract: A new halimane diterpene, 3beta,5beta, 16alpha-trihydroxyhalima-13(14)-en-15,16-olide (1), and a new oxoprotoberberine alkaloid, (-)-8-oxopolyalthiaine (2), along with 20 known compounds, were isolated from a methanolic extract of Polyalthia longifolia var. pendula. The structures of compounds 1 and 2 were established by spectroscopic analysis. Several of these compounds were evaluated for cytotoxicity toward a small panel of human cell lines.
authors.affiliation: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: F R
authors.initials: FR
authors.lastname: Chang
authors.forename: Y C
authors.initials: YC
authors.lastname: Shih
authors.forename: T J
authors.initials: TJ
authors.lastname: Hsieh
authors.forename: Y C
authors.initials: YC
authors.lastname: Chia
authors.forename: H Y
authors.initials: HY
authors.lastname: Tseng
authors.forename: H C
authors.initials: HC
authors.lastname: Chen
authors.forename: S J
authors.initials: SJ
authors.lastname: Chen
authors.forename: M C
authors.initials: MC
authors.lastname: Hsu
authors.forename: Y C
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001600:Berberine Alkaloids; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: C418225:3,5,16-trihydroxyhalima-13(14)-en-15,16-olide; C418226:8-oxopolyalthiaine; D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001600:Berberine Alkaloids; D004224:Diterpenes; D010936:Plant Extracts