Antifungal activity of new 1,3,4-oxadiazolo[3,2-a]-s-triazine-5, 7-diones and their 5-thioxo-7-ones.
N(1)- and N(3)-(4-fluorophenyl) ureas (III a-e) were cyclocondensed with ethyl chloroformate and CS(2)/KOH to yield 2-aryl-6-(4-fluorophenyl)-1,3,4-oxadiazolo[3,2-a]-s-triazine-5, 7-diones (IVa-e) and their 5-thioxo-7-ones (Va-e), respectively. The compounds III-V(a-e) have been compared with Dithane M-45 for their fungitoxic action against A. niger and F. oxyporum, and the results have been correlated with the structural features of the tested compounds.
Mishra
A R
AR
Department of Chemistry, College, Azamgarh, India.
Singh
S
S
Wahab
A
A
D001234:Aspergillus niger / Q000187:drug effects*; D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects*; D008968:Molecular Conformation; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D005659:Fungicides, Industrial; D010069:Oxadiazoles; D014227:Triazines