title: Effects of early pre- and postoperative irradiation on the healing of microvascular anastomoses.
abstract: A comparative study was undertaken to evaluate the possible effects of time selection of irradiation on the healing of microvascular anastomoses. In this experimental study, 40 adult male Sprague-Dawley rats were divided into four groups, 10 animals in each. In Group 1, the rats were exposed to radiotherapy with a dose of 20 Gy in a single fraction at a 170,916 cby/min dose rate, at an 80-cm source to a skin distance from 3 to 4 cm in the right groin fields involving the femoral artery, using a Co60 megavoltage radiotherapy machine. The animals were operated on under general anesthesia 2 weeks later. During the operation, femoral microarterial anastomoses were performed. In Group 2, the rats were irradiated and operated on as in Group 1, on the same day. In Group 3, the rats were operated on and, 2 weeks later, irradiated, as in Group 1. In Group 4 (control group), the rats were operated on as in Group 1. No radiotherapy was performed. All rats were explored under general anesthesia after 1 month. Patency was evaluated, and the anastomotic sites were taken for histopathologic and electron microscopy studies. The authors found that there were no major differences in the healing of microvascular anastomoses in the early preoperative, immediate preoperative, and early postoperative irradiated groups. The patency rates of all radiotherapy groups were not statistically different from control arteries (p > 0.05).
authors.affiliation: Department of Plastic and Reconstructive Surgery, Istambul School of Medicine, University of Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Arinci
authors.forename: M
authors.initials: M
authors.lastname: Topalan
authors.forename: I
authors.initials: I
authors.lastname: Aydin
authors.forename: S
authors.initials: S
authors.lastname: solakoglu
authors.forename: V
authors.initials: V
authors.lastname: Olgaç
authors.forename: R
authors.initials: R
authors.lastname: Merla
authors.forename: M
authors.initials: M
authors.lastname: Erer
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D003037:Cobalt Radioisotopes; D005263:Femoral Artery / Q000601:surgery*; D008297:Male; D008866:Microsurgery / Q000379:methods; D011882:Radiotherapy, High-Energy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014945:Wound Healing / Q000528:radiation effects*
chemical_list: D003037:Cobalt Radioisotopes