Synthesis and antifungal activity of novel bisdithiocarbamate derivatives of carbohydrates against Fusarium oxysporum f. sp. lini.
Novel carbamic esters possessing a carbohydrate moiety derived from glycerol or D-glucose with two N,N-diethyldithiocarbamoyl groups and a series of bisdithiocarbamic esters having a ketone or an alkyl ester have been synthesized. The in vitro activity of these new compounds was evaluated against Fusarium oxysporum f. sp. lini. Some of the compounds [bis[1,3-S-(N,N-diethyldithiocarbamoyl)]-1, 3-dideoxyglycerol) and diethyl N,N'-(1,3-dideoxyglycer-1, 3-diyl)bis(dithiocarbamate)] were more active for inhibiting vegetative mycelium growth than, respectively, the commercial N, N-diethyldithiocarbamic acid sodium salt and Maneb. The structure activity of these new compounds is discussed.
Rafin
C
C
Laboratoire de Chimie Organique et Cinétique, Université de Picardie-Jules Verne, 80039 Amiens, France.
Veignie
E
E
Sancholle
M
M
Postel
D
D
Len
C
C
Villa
P
P
Ronco
G
G
D005659:Fungicides, Industrial / Q000138:chemical synthesis* / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects*; D005947:Glucose; D005990:Glycerol; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013859:Thiocarbamates / Q000138:chemical synthesis* / Q000494:pharmacology
D005659:Fungicides, Industrial; D013859:Thiocarbamates; D005947:Glucose; D005990:Glycerol