Effect of smoking on lipid profile, lipid peroxidation and antioxidant status in normal subjects and in patients during and after acute myocardial infarction.
We studied changes in lipid peroxidation, vitamin E status and lipid profile due to smoking in healthy subjects, patients with acute myocardial infarction (MI), and in stabilized patients surviving MI. A significant increase in malondialdehyde (MDA) concentrations was observed in MI patients, more than in smokers (P<0.05), as compared to control. The plasma vitamin E as well as the ratio of vitamin E/lipids were significantly lower in MI patients as compared to stable ischemic heart disease (IHD) patients and controls. Our data show that smoking is associated with lowered antioxidant status in MI.
Kharb
S
S
Department of Biochemistry, Postgraduate Institute of Medical Sciences, Rohtak, India.
Singh
G P
GP
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D017202:Myocardial Ischemia / Q000097:blood; D012907:Smoking / Q000009:adverse effects*; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D008055:Lipids; D014810:Vitamin E; D008315:Malondialdehyde; D002784:Cholesterol