title: Cardiac valve replacement: a bioengineering approach.
abstract: The second most common major heart operation in the western world is valve replacement. Any one of the four heart valves may become either so stenotic or regurgitant that it needs to be replaced in order to restore normal heart function. Although replacement surgery of dysfunctional heart valves has a very high success rate, it can provide the surgeon with a difficult decision regarding the choice of a suitable prosthesis for the individual patient. Over the years many different types of artificial heart valves have been devised. Surgeons typically deal with a heart valve replacement by installing a mechanical prosthesis or by using a bioprosthetic valve, hand-crafted from animal tissue. Least commonly, valves can be taken from human organ donors. Mechanical valve substitutes have a long fatigue life but the central flow occluders often induce blood cell trauma. Tissue substitutes have an unimpeded central orifice when open, cause minimal cell damage but have a relatively short fatigue life, especially in children where calcification may be a major problem. More recently alternative materials, such as polyurethane, have been used in artificial heart valve design while the new concept of tissue-engineering has enhanced the prospects towards an ideal cardiac valve replacement. Today's artificial valves are designed with a better understanding of the cardiovascular system with the aid of computers. Advances in computer software have allowed simulations of fluid flows through valve substitutes, both in cardiac flow simulators and the heart itself.
authors.affiliation: Department of Mechanical Engineering, Leeds University, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Korossis
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.forename: E
authors.initials: E
authors.lastname: Ingham
mesh_terms: D000818:Animals; D001698:Biomedical Engineering / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends; D001705:Bioprosthesis / Q000009:adverse effects / Q000592:standards* / Q000706:statistics & numerical data; D017076:Computer-Aided Design; D006350:Heart Valve Prosthesis / Q000009:adverse effects / Q000592:standards* / Q000706:statistics & numerical data; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011475:Prosthesis Failure; D013552:Swine; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data