Helicobacter pylori serology and the diagnosis of H. pylori infection in children.
Serological screening accuracy rate may be dependent on clinical and pathological determinants. The aim of this study was to evaluate the accuracy of Hp serology test (Roche Biomedical Lab., Labcorp), in the diagnosis of Hp infection in 121 children who were seen in the Pediatric Gastoenterology Clinic at the Marshall University Joan C. Edwards School of Medicine in Huntington. Positive serology detected children with Hp-associated gastritis with a sensitivity of 51.6%. Positive serology significantly correlated with the degree of gastric inflammation and density of Hp organisms in the gastric mucosa (ANOVA p < 0.001). The Labcorp. Hp-ELISA test had a poor accuracy rate for the detection of Hp-gastritis in children. Gastric biopsies should always be performed to establish the diagnosis of Hp infection in children.
Elitsur
Y
Y
Dept. of Pediatrics, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Aflak
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R
Neace
C
C
Triest
W E
WE
D000293:Adolescent; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male; D011933:Reagent Kits, Diagnostic; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D012703:Serotyping / Q000379:methods*
D011933:Reagent Kits, Diagnostic