title: Three new scalarane sesterterpenoids from the Okinawan sponge Hyrtios erectus.
abstract: Three new scalarane sesterterpenoids-hyrtiolide (1), 16-hydroxyscalarolide (2), and 12-deacetyl-Delta(17)-hyrtial (3), were isolated from Okinawan sponge Hyrtios erectus, along with scalarolide (4) and 12-deacetylhyrtial (5). The structures of new compounds 1-3 were determined by spectroscopic analysis and chemical conversions. Compounds 3 and 5 showed antiproliferative activity toward KB cells.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Miyaoka
authors.forename: S
authors.initials: S
authors.lastname: Nishijima
authors.forename: H
authors.initials: H
authors.lastname: Mitome
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000818:Animals; D007564:Japan; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000302:isolation & purification*
chemical_list: D013729:Terpenes