title: ["Hetero to homo" allogeneic bone marrow transplantation from a related donor with two HLA loci mismatch].
abstract: We describe a 46-year-old HLA-homozygous female patient with CML who received a bone marrow transplant from her son, who had two HLA (A, B) loci mismatch. After conditioning with total body irradiation plus cyclophosphamide, the patient received 4.8 x 10(8) bone marrow cells/kg. Cyclosporin and short-term methotrexate were used for GVHD prophylaxis. She successfully established rapid engraftment with no acute GVHD, and later developed chronic but mild GVHD. Family members with two HLA loci mismatch may be considered as candidate donors for "hetero to homo" bone marrow transplantation.
authors.affiliation: Department of Hematology, National Kyushu Cancer Center Hospital.
authors.forename: R
authors.initials: R
authors.lastname: Kawano
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Noguchi
authors.forename: T
authors.initials: T
authors.lastname: Goto
authors.forename: H
authors.initials: H
authors.lastname: Takatsuki
authors.forename: Y
authors.initials: Y
authors.lastname: Yufu
authors.forename: N
authors.initials: N
authors.lastname: Uike
mesh_terms: D016026:Bone Marrow Transplantation; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000628:therapy; D008875:Middle Aged
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens