A rotaxane-like complex with controlled-release characteristics.
A rotaxane-like complex, based on a dumbbell-shaped component containing an NH(2)(+) recognition site for a [25]crown-8 ring component and a slippage stopper in the form of a p-(tert-butyl)phenyl group, has been synthesized by a "threading-followed-by-stoppering" approach. The half-life for dissociation of this complex, which is very sensitive to its environment, can be varied from minutes to months by changing the temperature and the polarity of the solvent.
Chiu
S H
SH
Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095-1569, USA.
Rowan
S J
SJ
Cantrill
S J
SJ
Glink
P T
PT
Garrell
R L
RL
Stoddart
J F
JF
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D002073:Butanes / Q000737:chemistry*; D003500:Cyclization; D003692:Delayed-Action Preparations; D004988:Ethers, Cyclic / Q000008:administration & dosage / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013696:Temperature
D000588:Amines; D002073:Butanes; D003692:Delayed-Action Preparations; D004988:Ethers, Cyclic; D007202:Indicators and Reagents