title: Intelligence and event-related potentials for young female human volunteer apolipoprotein E epsilon4 and non-epsilon4 carriers.
abstract: The apolipoprotein E (APOE) epsilon4 allele is associated with late-onset Alzheimer's disease and cognitive function in aging normal populations. To study the effect of the presence of the epsilon4 allele on cognitive function, we compared intelligence-test scores and component values for event-related potentials for epsilon4 and non-epsilon4 carriers in a group of 134 young females. The results demonstrate modest increases in performance intelligence quotient (IQ) and N100 amplitude for epsilon4 carriers (P=0.038 and 0.068, respectively). Our findings suggest that cognitive impairment, associated with the presence of the epsilon4 allele, is age-dependent and thus not probable for young women. The higher performance IQ scores demonstrated for epsilon4 carriers require further exploration.
authors.affiliation: Yu's Psychiatric Clinic, Kaohsiung, Taiwan, ROC.
authors.forename: Y W
authors.initials: YW
authors.lastname: Yu
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
authors.forename: S P
authors.initials: SP
authors.lastname: Chen
authors.forename: C J
authors.initials: CJ
authors.lastname: Hong
authors.forename: S J
authors.initials: SJ
authors.lastname: Tsai
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D005072:Evoked Potentials, Auditory / Q000235:genetics*; D005260:Female; D006579:Heterozygote; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D007361:Intelligence Tests
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E