title: Stochastic spreading of intracellular Ca(2+) release.
abstract: We study the spreading of calcium-induced calcium release with the stochastic DeYoung-Keizer-model of the inositol 1,4,5-trisphosphate receptor channel. The model shows a transition from isolated release events to steadily propagating waves with increasing IP3 concentration. A state--stochastic backfiring--was found in the regime of steady propagation. The model can be reduced by an adiabatic elimination of the partial differential equation for the Ca(2+) concentration to a lattice of stochastic channel clusters.
authors.affiliation: Physics Department, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0319, USA.
authors.forename: M
authors.initials: M
authors.lastname: Falcke
authors.forename: L
authors.initials: L
authors.lastname: Tsimring
authors.forename: H
authors.initials: H
authors.lastname: Levine
mesh_terms: D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D020013:Calcium Signaling; D003198:Computer Simulation; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008954:Models, Biological; D011336:Probability; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013269:Stochastic Processes
chemical_list: D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium