title: Anti-cardiolipin autoantibodies and pulmonary embolism. A case for a common cause.
abstract: A patient with primary Sjögren's syndrome developed pulmonary embolism following infection with influenza A virus. IgM anti-cardiolipin autoantibodies (aCL) evolved two weeks after hospitalisation, synchronously with antibodies against influenza A. IgG aCL developed three weeks after hospitalization, peaked during the recovery period, and gradually declined to undetectable levels 12 months after admission. Antibodies against beta2 glycoprotein I were not detected. Our results assign a high likelihood to the hypothesis that influenza A virus caused the patient's thromboembolic disease as well as development of aCL. aCL may have contributed to tissue pathology by forming immune-complexes with cardiolipin and rheumatoid factor.
authors.affiliation: Department of Microbiology and Immunology, The Gade Institute, Haukeland University Hospital, Bergen, Norway. elling.ulvestad@haukeland.no
authors.forename: E
authors.initials: E
authors.lastname: Ulvestad
authors.forename: A
authors.initials: A
authors.lastname: Kanestrøm
authors.forename: P
authors.initials: P
authors.lastname: Tengnér
authors.forename: S
authors.initials: S
authors.lastname: Gjerde
authors.forename: J
authors.initials: J
authors.lastname: Sundal
authors.forename: H J
authors.initials: HJ
authors.lastname: Haga
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D000914:Antibodies, Viral / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D009980:Influenza A virus / Q000276:immunology / Q000302:isolation & purification; D007251:Influenza, Human / Q000150:complications* / Q000276:immunology; D011655:Pulmonary Embolism / Q000209:etiology* / Q000276:immunology; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications*; D013997:Time Factors
chemical_list: D017153:Antibodies, Anticardiolipin; D000914:Antibodies, Viral; D007074:Immunoglobulin G