title: [Acute mountain sickness: the clinical characteristics of a cohort of 615 patients].
abstract: OBJECTIVE
  To study the acute mountain sickness (AMS) and the influence the altitude has on individuals according to time of exposure, age and place of residence. Study cohort prospective in the shelters of Cotopaxi and Chimborazo (4,800 and 5,000 m), in the Ecuatorian Andes.
  
  
  METHODS
  Tourists from 8 to 51 years of age, residents of the coastal and mountain regions, exposed suddenly to the altitude. Signs and symptoms were recorded at 2, 8, 20 and 24 h of exposure and categorized according to the degree of acute mountain sickness found: AMS 1 [4 to 7 points (light), AMS 2 [8 to 11 points (moderate)] and AMS 3 [more than 12 points (severe)].
  
  
  RESULTS
  The study, consisted of 615 patients, was completed by 564. Neurological symptoms are prevalent (headache in the 81.7% of patients) over cardiopulmonary symptoms (cardiac frequency over 100/min in the 25.6%). At 20 h (after one night), the signs and symptoms are more intense and affect a greater number of people (p < 0.0001). Patients from 8 to 22 years of age and residents of the coast have a greater risk of developing AMS 2 (p < 0.01). Overweight, a sedentary life style and a previous incidence of altitude sickness are factors which contribute to the development of AMS 2 (p < 0.001).
  
  
  CONCLUSIONS
  AMS is an important neurological affection. Young people, individuals from sea-level, as well as those whose are overweight, sedentary or who have previously experienced AMS, have a higher risk of developing AMS 2 after a sudden exposure to altitudes between 4,800 and 5,000 meters. Lack of balance and coordination, and shortness of breath at rest imply AMS 3 and the presence of high altitude cerebral or pulmonary edema.
authors.affiliation: Servicio de Neurología. Hospital Carlos Andrade Marín. Instituto Ecuatoriano de Seguridad Social. Facultad de Medicina. Pontificia Universidad Católica de Ecuador, Quito. serranom@pi.pro.ec
authors.forename: M
authors.initials: M
authors.lastname: Serrano-Dueñas
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000532:Altitude Sickness / Q000175:diagnosis*; D016009:Chi-Square Distribution; D002648:Child; D015331:Cohort Studies; D004484:Ecuador; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011336:Probability; D011446:Prospective Studies; D013997:Time Factors