Simocyclinones, novel cytostatic angucyclinone antibiotics produced by Streptomyces antibioticus Tü 6040. I. Taxonomy, fermentation, isolation and biological activities.
Two novel angucyclinone-type antibiotics, simocyclinones D4 and D8, were detected in the mycelium extract of Streptomyces antibioticus Tü 6040 by HPLC-diode-array and HPLC-electrospray-mass-spectrometry screening. The compounds show antibiotic activities against Gram-positive bacteria and cytostatic effects on various tumor cell lines.
Schimana
J
J
Mikrobiologisches Institut, Universität Tübingen, Germany.
Fiedler
H P
HP
Groth
I
I
Süssmuth
R
R
Beil
W
W
Walker
M
M
Zeeck
A
A
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D003374:Coumarins / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006027:Glycosides / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D013303:Streptomyces antibioticus / Q000145:classification / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003374:Coumarins; D006027:Glycosides; C416815:simocyclinone D4; C416814:simocyclinone D8