title: Dementia with Lewy bodies in a neuropathologic series of suspected Creutzfeldt-Jakob disease.
abstract: Discriminating Creutzfeldt-Jakob disease (CJD) from dementia with Lewy bodies (DLB) may be clinically difficult to achieve. The authors describe 10 patients with DLB initially referred to the French Network of Human Spongiform Encephalopathies as having suspected CJD. In a series of 465 autopsied cases, DLB ranked second among degenerative alternative diagnoses to CJD. The authors analyzed the factors that contributed to misleading the diagnosis, and suggest that the detection of 14-3-3 protein in CSF may be useful to distinguish CJD from DLB.
authors.affiliation: Raymond Escourolle Neuropathology Laboratory, Pitié-Salpêtrière Hospital, Paris, France. haik@mailhost.chups.jussieu.fr
authors.forename: S
authors.initials: S
authors.lastname: Haïk
authors.forename: J P
authors.initials: JP
authors.lastname: Brandel
authors.forename: V
authors.initials: V
authors.lastname: Sazdovitch
authors.forename: N
authors.initials: N
authors.lastname: Delasnerie-Lauprêtre
authors.forename: K
authors.initials: K
authors.lastname: Peoc'h
authors.forename: J L
authors.initials: JL
authors.lastname: Laplanche
authors.forename: N
authors.initials: N
authors.lastname: Privat
authors.forename: C
authors.initials: C
authors.lastname: Duyckaerts
authors.forename: J L
authors.initials: JL
authors.lastname: Kemeny
authors.forename: N
authors.initials: N
authors.lastname: Kopp
authors.forename: A
authors.initials: A
authors.lastname: Laquerrière
authors.forename: M
authors.initials: M
authors.lastname: Mohr
authors.forename: J P
authors.initials: JP
authors.lastname: Deslys
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: J J
authors.initials: JJ
authors.lastname: Hauw
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology* / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology* / Q000503:physiopathology