title: Generalized cutaneous depigmentation following sulfamide-induced drug eruption.
abstract: A 41-year-old male developed a generalized drug eruption following sulfamide therapy, with progressive albino-like generalized cutaneous depigmentation. Electron microscopy showed the absence of melanocytes, and clear cells with Langerhans cell characteristics were seen along the basal layer. The present case constitutes a unique reaction to sulfamides not previously reported in the literature.
authors.affiliation: Department of Dermatology, Hospital Clínico Universitario, Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Ruiz
authors.forename: C
authors.initials: C
authors.lastname: Ortega
authors.forename: L
authors.initials: L
authors.lastname: Calduch
authors.forename: I
authors.initials: I
authors.lastname: Molina
authors.forename: E
authors.initials: E
authors.lastname: Montesinos
authors.forename: A
authors.initials: A
authors.lastname: Revert
authors.forename: C
authors.initials: C
authors.lastname: Cardá
authors.forename: V
authors.initials: V
authors.lastname: Navarro
authors.forename: E
authors.initials: E
authors.lastname: Jordá
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D017496:Hypopigmentation / Q000139:chemically induced*; D008297:Male; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination