title: 16Beta-hydroxy-5alpha-cholestane-3,6-dione, a novel cytotoxic oxysterol from the red alga Jania rubens.
abstract: A new cytotoxic oxysterol, 16beta-hydroxy-5alpha-cholestane-3,6-dione was isolated from the red alga Jania rubens. Its structure was established by spectroscopic method. The ID50 value was 0.5 microg/mL.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles, associé au CNRS, Muséum National d'Histoire Naturelle, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Ktari
authors.forename: A
authors.initials: A
authors.lastname: Blond
authors.forename: M
authors.initials: M
authors.lastname: Guyot
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D002778:Cholestanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D000461:Rhodophyta / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: C420965:16-hydroxycholestane-3,6-dione; D000972:Antineoplastic Agents, Phytogenic; D002778:Cholestanones