title: [Split-course radiotherapy or treatment interruption].
abstract: BACKGROUND
  Experimental and clinical studies have shown that a prolonged overall treatment time is associated with a decrease in local tumor control.
  
  
  METHODS
  In a brief review, the clinical data of radiotherapy with split-course or treatment interruption were collected.
  
  
  CONCLUSIONS
  There was a detrimental effect of the treatment interruption on overall or disease-specific survival in patients with locally advanced head and neck cancer or non-small-cell lung cancer in particular in patients with good prognostic factors and well to moderate differentiated tumors. Therefore, interruption of radiotherapy in patients with curative treatment should be avoided.
authors.affiliation: Klinik für Radioonkologie-Strahlentherapie Klinikum Fulda. hjfeldmann.raz@klinikum-fulda.de
authors.forename: H J
authors.initials: HJ
authors.lastname: Feldmann
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy*; D002986:Clinical Trials as Topic; D019583:Dose Fractionation, Radiation; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D015999:Multivariate Analysis; D011379:Prognosis; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013997:Time Factors