title: Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions.
abstract: We have determined Y-chromosomal DNA haplotypes in 73 infertile European males carrying Y microdeletions and compared them with the haplotypes of 299 infertile males lacking microdeletions. Chromosomes were typed with a set of 11 binary Y markers, which identified 8 haplogroups in the sample. Haplogroup frequencies were compared between 3 microdeletion classes and the non-deleted infertile males. Deletions arise on many different haplotypic backgrounds. No statistically significant differences in frequency were seen, although the small number of AZFa deletions lay predominantly on one branch of the Y haplotype tree.
authors.affiliation: Department of Biochemistry, University of Oxford, UK.
authors.forename: S
authors.initials: S
authors.lastname: Paracchini
authors.forename: L
authors.initials: L
authors.lastname: Stuppia
authors.forename: V
authors.initials: V
authors.lastname: Gatta
authors.forename: G
authors.initials: G
authors.lastname: Palka
authors.forename: E
authors.initials: E
authors.lastname: Moro
authors.forename: C
authors.initials: C
authors.lastname: Foresta
authors.forename: L
authors.initials: L
authors.lastname: Mengua
authors.forename: R
authors.initials: R
authors.lastname: Oliva
authors.forename: J L
authors.initials: JL
authors.lastname: Ballescà
authors.forename: J A
authors.initials: JA
authors.lastname: Kremer
authors.forename: R J
authors.initials: RJ
authors.lastname: van Golde
authors.forename: J H
authors.initials: JH
authors.lastname: Tuerlings
authors.forename: T
authors.initials: T
authors.lastname: Hargreave
authors.forename: A
authors.initials: A
authors.lastname: Ross
authors.forename: H
authors.initials: H
authors.lastname: Cooke
authors.forename: K
authors.initials: K
authors.lastname: Huellen
authors.forename: P H
authors.initials: PH
authors.lastname: Vogt
authors.forename: C
authors.initials: C
authors.lastname: Tyler-Smith
mesh_terms: D004247:DNA / Q000235:genetics*; D005060:Europe; D017353:Gene Deletion; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D010802:Phylogeny; D014998:Y Chromosome / Q000235:genetics*
chemical_list: D004247:DNA