[Photodynamic diagnosis and photodynamic therapy for experimental hepatoma with ME 2906].
We studied the effects of photodynamic diagnosis (PDD) and photodynamic therapy (PDT) in confirming the existence of hepatoma, using the new photosensitizer mono-L-aspartyl chlorine 6. Japanese white rabbits were selected for abdominal incision under intravenous anesthesia, and VX 2 tumor cells were transplanted into the left liver lobe to create a hepatoma model. In the experiment, hepatoma of 1 cm in diameter (at one week after transplantation) was radiated with a semiconducter laser (664 nm, 200 J/cm2) for treatment.
Nakamura
J
J
3rd Dept. of Surgery, Toho University School of Medicine.
Sumiyama
Y
Y
Kajiwara
H
H
Nakamura
M
M
Watanabe
M
M
Tanaka
H
H
Terada
T
T
Nagao
J
J
Kusachi
S
S
Saida
Y
Y
Usui
S
S
Aizawa
K
K
D000818:Animals; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008114:Liver Neoplasms, Experimental / Q000175:diagnosis / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins; D011817:Rabbits
C110704:PH-1126; D017319:Photosensitizing Agents; D011166:Porphyrins; D002734:Chlorophyll; C053434:Talaporfin