Antiallergic effect of apple polyphenols on the allergic model mouse.
We studied here the antiallergic effect of apple condensed tannins (ACT) administered orally to a type I allergy model mouse transplanted with an IgEL a2 hybridoma secreting anti-2,4,6-trinitrophenyl (TNP) immunoglobulin E (IgE). The oral administration of ACT significantly inhibited the ear swelling responses at 1 h after antigen-stimulation with picryl chloride. The response was dose dependent within 0.1 to 10 mg/mouse. The inhibition of the ear swelling response reached the maximal level (90% inhibition) when ACT was administered 2 h before the antigen challenge. These findings suggest that ACT has an antiallergic effect on type I allergic symptoms.
Akiyama
H
H
National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
Sakushima
J
J
Taniuchi
S
S
Kanda
T
T
Yanagida
A
A
Kojima
T
T
Teshima
R
R
Kobayashi
Y
Y
Goda
Y
Y
Toyoda
M
M
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000188:drug therapy / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005419:Flavonoids; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006825:Hybridomas / Q000473:pathology; D006967:Hypersensitivity / Q000188:drug therapy* / Q000473:pathology; D007073:Immunoglobulin E / Q000276:immunology; D007665:Ketotifen / Q000494:pharmacology; D027845:Malus / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols
D018926:Anti-Allergic Agents; D005419:Flavonoids; D006634:Histamine H1 Antagonists; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D007073:Immunoglobulin E; D007665:Ketotifen