Failure to infect congenitally immunodeficient SCID and NUDE mice with Rhinosporidium seeberi.
Congenitally T and B cell-deficient SCID mice and T cell-deficient NUDE mice, with BALB/c mice as immunologically normal controls, were inoculated with Rhinosporidium seeberi. At 3 and 16 weeks after inoculation, no evidence of rhinosporidiosis was detected. The reasons for the failure to establish rhinosporidiosis in immunodeficient or normal mice remain obscure.
Arseculeratne
S N
SN
Department of Microbiology & Parasitology, Universiti Sains Malaysia. ratne@slt.lk
Hussein
F N
FN
Atapattu
D N
DN
Pathmanathan
R
R
D000818:Animals; D005260:Female; D007153:Immunologic Deficiency Syndromes / Q000382:microbiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016513:Mice, SCID; D012227:Rhinosporidiosis / Q000276:immunology* / Q000382:microbiology; D012228:Rhinosporidium / Q000472:pathogenicity*