title: Auditory and visual event-related potentials in alcoholics: abnormalities of components and brain electrical field.
abstract: Alterations of ERPs recorded over midline scalp sites have frequently been reported in alcoholics. To assess the P3 and other ERP components topographically, auditory and visual ERPs were recorded from 33 scalp electrodes in abstinent alcoholics and healthy controls using an oddball paradigm. At the Cz electrode the alcoholics showed decreased visual N1 and increased auditory N2 amplitudes. Topographically, the negative centroids of the visual N1 and P3 and the auditory N2 differed between groups, and the positive centroid of the visual P3 was displaced toward the right hemisphere. While no valid diagnostic classification could be obtained by using the traditional ERP component P3 recorded from Pz, the combination of visual N1 and auditory N2 amplitudes at Cz with centroid parameters amounted to 51% explained variance and 92% correct discrimination of alcoholics from controls. Abnormalities of N1 amplitude and P3 topography similar to the current findings in alcoholics have previously been described for schizophrenics.
authors.affiliation: Psychiatric University Clinic, Freiburg, Germany. Hans_Olbrich@psyallg.ukl.uni-freiburg.de
authors.forename: H M
authors.initials: HM
authors.lastname: Olbrich
authors.forename: H
authors.initials: H
authors.lastname: Maes
authors.forename: H
authors.initials: H
authors.lastname: Gann
authors.forename: F
authors.initials: F
authors.lastname: Hagenbuch
authors.forename: B
authors.initials: B
authors.lastname: Feige
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology* / Q000534:rehabilitation; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004569:Electroencephalography; D004585:Electrooculography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006760:Hospitalization; D006801:Humans; D012720:Severity of Illness Index; D016320:Substance Abuse Treatment Centers