Antigiardial activity of isoflavones from Dalbergia frutescens bark.
Several isoflavones [formononetin (1), castanin (5), odoratin (6), glycitein (7), pseudobaptogenin (8), fujikinetin (9), and cuneatin (10)] were isolated from Dalbergia frutescens, and their antiprotozoal activities were determined against Giardia intestinalis. Among these compounds, formononetin (1) was the most potent antigiardial agent, with an IC(50) value of 30 ng/mL (approximately 0.1 microM), as compared to the value for metronidazole, the current drug of choice, of 100 ng/mL (approximately 0.6 microM). Three isoflavones closely related to formononetin [daidzein (2), biochanin A (3) and genistein (4)] were also evaluated, but they were at least 100 times less active than 1. Formononetin (1) may thus be an interesting lead for development of new antigiardial agents or as a probe for a new mechanistic target.
Khan
I A
IA
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, Mississippi 38677, USA.
Avery
M A
MA
Burandt
C L
CL
Goins
D K
DK
Mikell
J R
JR
Nash
T E
TE
Azadegan
A
A
Walker
L A
LA
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D016829:Giardia lamblia / Q000187:drug effects*; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal
D000981:Antiprotozoal Agents; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; C007768:formononetin; C060800:psi-baptigenin