Synthesis of slagenins A, B, and C.
[structure: see text] A short synthesis of the marine sponge metabolites slagenins A (1), B (2), and C (3) is described. The synthetic route features the preparation of beta-hydroxyimidazolone 4 from ornithine and its subsequent oxidative cyclization to the slagenin core.
Barrios Sosa
A C
AC
Department of Chemistry, Oregon State University, Corvallis, Oregon 97331, USA.
Yakushijin
K
K
Horne
D A
DA
D000818:Animals; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D011161:Porifera
D003603:Cytotoxins; D005663:Furans; D007093:Imidazoles; D007202:Indicators and Reagents; C416728:slagenin A; C416726:slagenin B; C416727:slagenin C