Acute renal failure: unusual complication of Epstein-Barr virus-induced infectious mononucleosis.
A 17-year-old boy with juvenile rheumatoid arthritis presented with jaundice, confusion, hemolytic anemia, thrombocytopenia, and acute renal failure secondary to titer-confirmed acute Epstein-Barr virus (EBV). Renal biopsy specimen revealed interstitial nephritis with an inflammatory infiltrate composed of cytotoxic/suppressor T cells, and interstitial mononuclear cell nuclei expressed EBV encoded RNA-1 (EBER-1) mRNA. Methylprednisolone treatment resulted in rapid improvement.
Lei
P S
PS
Department of Pediatrics, University of Utah School of Medicine and Primary Children's Medical Center, Salt Lake City, UT 84132, USA.
Lowichik
A
A
Allen
W
W
Mauch
T J
TJ
D058186:Acute Kidney Injury / Q000209:etiology* / Q000821:virology; D000293:Adolescent; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007244:Infectious Mononucleosis / Q000150:complications* / Q000821:virology; D007668:Kidney / Q000473:pathology / Q000821:virology; D008297:Male; D009395:Nephritis, Interstitial / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics
C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral