Ventricular thrombosis in Sipple's syndrome.
An 18-year-old girl with multiple endocrine neoplasia type 2 (Sipple's syndrome) had a large intraventricular mass that proved to be a thrombus. She had no apparent precipitating factor for intracavitary thrombus formation. This is the first reported case of multiple endocrine neoplasia associated with ventricular thrombus. A hypercoagulable state resulting from catecholamine-induced and serotonin-induced platelet hyperaggregability might have been the causative mechanism.
Pishdad
G R
GR
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Iran.
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000503:physiopathology; D001777:Blood Coagulation / Q000502:physiology; D018276:Carcinoma, Medullary / Q000150:complications / Q000503:physiopathology; D002395:Catecholamines / Q000097:blood; D005260:Female; D006331:Heart Diseases / Q000150:complications*; D006801:Humans; D018813:Multiple Endocrine Neoplasia Type 2a / Q000150:complications*; D009378:Neoplasms, Multiple Primary / Q000503:physiopathology; D010673:Pheochromocytoma / Q000150:complications / Q000503:physiopathology; D012701:Serotonin / Q000378:metabolism; D013927:Thrombosis / Q000150:complications*; D013964:Thyroid Neoplasms / Q000150:complications / Q000503:physiopathology
D002395:Catecholamines; D012701:Serotonin