title: Nonhepatosplenic gamma delta T-cell lymphoma with initial testicular compromise.
abstract: We report here a case of nonhepatosplenic gammadelta T-cell lymphoma with undescribed initial localization in testis, without hepatosplenomegaly or adenopathies, and subsequent development in the maxillary sinus. The maxillar mass biopsy revealed a T-cell infiltration, and its immunologic characterization by flow cytometry showed a gammadelta T-cell phenotype (CD45+, CD3+, CD2+, TCR gammadelta+), without expression of CD7, CD5, CD1a, TdT, CD4, CD8, TCR alphabeta, or NK antigens (CD16, CD56, and CD57). Clonal gamma-chain gene rearrangement by polymerase chain reaction (PCR) was detected in testicular and maxillar biopsies. Epstein-Barr virus type 1 (EBV) sequences were detected by molecular biology in the biopsy material, suggesting that this oncogenic virus may play a role in the genesis of the clonal expansion of gammadelta T-cells. The patient was initially treated with standard chemotherapeutic protocols, with poor response and aggressive course.
authors.affiliation: Instituto de Investigaciones Hematológicas Mariano R. Castex, Academia Nacional de Medicina de Buenos Aires, Argentina. mscolnik@interlink.com.ar
authors.forename: M P
authors.initials: MP
authors.lastname: Scolnik
authors.forename: R A
authors.initials: RA
authors.lastname: Burgos
authors.forename: A
authors.initials: A
authors.lastname: Paz
authors.forename: M
authors.initials: M
authors.lastname: Weinreiter
authors.forename: M
authors.initials: M
authors.lastname: del Carmen Ardaiz
authors.forename: P
authors.initials: P
authors.lastname: Bare
authors.forename: M C
authors.initials: MC
authors.lastname: Hanza
authors.forename: M A
authors.initials: MA
authors.lastname: de Dios Soler
authors.forename: M I
authors.initials: MI
authors.lastname: Narbaitz
authors.forename: M F
authors.initials: MF
authors.lastname: Palacios
authors.forename: A
authors.initials: A
authors.lastname: Sasot
authors.forename: A
authors.initials: A
authors.lastname: Huberman
authors.forename: M M
authors.initials: MM
authors.lastname: de Bracco
mesh_terms: D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000473:pathology; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D013160:Splenic Neoplasms / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta