title: [Dofetilide to patients with heart failure and left ventricular dysfunction].
abstract: BACKGROUND
  Dofetilide, a new class III antiarrhythmic drug, was tested for its ability to reduce mortality and morbidity in patients with congestive heart failure and left ventricular dysfunction.
  
  
  METHODS
  In 34 Danish centers, 1518 patients with NYHA class III or IV heart failure and wall motion index of the left ventricle < or = 1.2 (ejection fraction < or = 35%) were randomized to receive dofetilide or placebo in a double blind study. The dose of dofetilide was adjusted to renal function and the QT interval. Patients were monitored continuously with ekg during the first three days in the study. Minimum follow up was one year.
  
  
  RESULTS
  Dofetilide did not affect mortality. Hospitalizations for worsening of heart failure were reduced significantly, hazard ratio 0.75 (0.63-0.89) Dofetilide effectively converted atrial fibrillation to sinus rhythm. After one year, 61% of patients with atrial fibrillation had converted on dofetilide and 33% on placebo (p < 0.001).
  
  
  CONCLUSIONS
  Dofetilide can be used to convert atrial fibrillation to sinus rhythm and to maintain sinus rhythm in patients with congestive heart failure and left ventricular dysfunction. Dofetilide does not affect mortality.
authors.affiliation: Kardiologisk afdeling, Odense Universitetshospital.
authors.forename: C T
authors.initials: CT
authors.lastname: Torp-Pedersen
authors.forename: M
authors.initials: M
authors.lastname: Møller
authors.forename: P E
authors.initials: PE
authors.lastname: Bloch-Thomsen
authors.forename: L
authors.initials: L
authors.lastname: Køber
authors.forename: E
authors.initials: E
authors.lastname: Sandøe
authors.forename: K
authors.initials: K
authors.lastname: Egstrup
authors.forename: E
authors.initials: E
authors.lastname: Agner
authors.forename: J E
authors.initials: JE
authors.lastname: Carlsen
authors.forename: J
authors.initials: J
authors.lastname: Videbaek
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000188:drug therapy; D002423:Cause of Death; D004311:Double-Blind Method; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D010627:Phenethylamines / Q000008:administration & dosage* / Q000009:adverse effects; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000188:drug therapy* / Q000401:mortality
chemical_list: D000889:Anti-Arrhythmia Agents; D010627:Phenethylamines; D013449:Sulfonamides; C063533:dofetilide