[Effect of the foreign gene GDNF on development of homo- and xenografts in the rat brain].
A transgenic line of Drosophila melanogaster was selected which carried the following genes: Delta, lacZ (for bacterial galactosidase), and human GDNF (for glial cell line-derived neurotrophic factor). Drosophila neuroectodermal embryonic cells were transplanted with the embryonic neurohomografts into the occipital brain region of an adult rat. Xenografts were found to block scar formation at the graft-host tissue boundary, stimulated homograft development (so that it was twice as large as the control homograft transplanted alone with no xenograft added), and noticeably improved vascularization of the homograft area.
Aleksandrova
M A
MA
Kol'tsov Institute of Developmental Biology, Russian Academy of Science, Moscow, Russia.
Pavlova
G V
GV
Revishchin
A V
AV
Bashkirov
V N
VN
Modestova
E A
EA
Evgen'ev
M B
MB
Saburina
I N
IN
Mertsalov
I B
IB
Vengrova
S P
SP
Korochkin
L I
LI
D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000601:surgery; D017690:Cell Transplantation; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology / Q000235:genetics*; D004625:Embryo, Nonmammalian / Q000166:cytology; D005260:Female; D016332:Fetal Tissue Transplantation; D018014:Gene Transfer Techniques; D051100:Glial Cell Line-Derived Neurotrophic Factor; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D007763:Lac Operon; D008565:Membrane Proteins / Q000235:genetics; D019579:Neocortex / Q000196:embryology / Q000637:transplantation*; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000235:genetics*; D051381:Rats; D012641:Selection, Genetic; D014183:Transplantation, Heterologous
C495039:GDNF protein, human; C495041:Gdnf protein, rat; D051100:Glial Cell Line-Derived Neurotrophic Factor; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; C064045:delta protein