Cardiac troponin T in neonates after acute and long-term tocolysis.
The present study was designed to determine the levels of cardiac troponin T (cTnT) in cord blood of neonates exposed in utero to tocolytic therapy by beta-sympathomimetics. cTnT in 40 neonates after acute tocolysis (0.24 +/- 0.05 microg/l) was significantly higher (p < 0.05) in comparison with the control group (0.05 +/- 0.01 microg/l). The maximal values were reached in about the 3rd day of therapy (0.39 +/- 0.11 microg/l). cTnT in 30 neonates after long-term tocolysis was 0.12 +/- 0.03 microg/l. No correlation was found between cTnT and CK and its isoenzyme CK-MB or ECG. CK, unlike cTnT, significantly correlated with gestational age (r = 0.57, p < 0.05) and birth weight (r = 0.55, p < 0.05). It is possible to conclude that acute tocolytic therapy by beta-sympathomimetics increases the cTnT levels in cord blood and cardiac troponin T is more useful for the laboratory diagnosis of neonatal myocardial injury than CK-MB.
Adamcová
M
M
Department of Physiology, Faculty of Medicine Charles University, Hradec Králové, Czech Republic. adamcova@lfhk.cuni.cz
Kokstein
Z
Z
Palicka
V
V
Vávrová
J
J
Podholová
M
M
Kost'ál
M
M
D000318:Adrenergic beta-Agonists / Q000009:adverse effects; D009202:Cardiomyopathies / Q000139:chemically induced; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000097:blood; D008297:Male; D009206:Myocardium / Q000201:enzymology; D011247:Pregnancy; D015145:Tocolysis / Q000009:adverse effects*; D015149:Tocolytic Agents / Q000009:adverse effects; D020107:Troponin T / Q000097:blood*
D000318:Adrenergic beta-Agonists; D007527:Isoenzymes; D015149:Tocolytic Agents; D020107:Troponin T; D003402:Creatine Kinase