Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.
Todde
S
S
CNR-INB, University of Milano-Bicocca, Scientific Institute H San Raffaele, Via Olgettina 60, I-20132 Milano, Italy.
Moresco
R M
RM
Simonelli
P
P
Baraldi
P G
PG
Cacciari
B
B
Spalluto
G
G
Varani
K
K
Monopoli
A
A
Matarrese
M
M
Carpinelli
A
A
Magni
F
F
Kienle
M G
MG
Fazio
F
F
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D016466:CHO Cells; D002250:Carbon Radioisotopes; D002460:Cell Line; D006224:Cricetinae; D015195:Drug Design; D006801:Humans; D007553:Isotope Labeling; D008024:Ligands; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000493:pharmacokinetics; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000378:metabolism / Q000493:pharmacokinetics; D051381:Rats; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D014162:Transfection
D002250:Carbon Radioisotopes; D008024:Ligands; D011720:Pyrazoles; D011743:Pyrimidines; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1; D011994:Recombinant Proteins; C416650:SCH 442416