A stereoselective route to hydroxyethylamine dipeptide isosteres.
An efficient synthesis of stereodefined hydroxyethylamine dipeptide isosteres has been developed, utilizing a syn-selective Grignard addition and reductive amination as the key reactions.
Datta
A
A
Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, USA. adutta@rx.pharma.ukans.edu
Veeresa
G
G
D004151:Dipeptides / Q000138:chemical synthesis*; D005021:Ethylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D013237:Stereoisomerism
D004151:Dipeptides; D005021:Ethylamines; D017320:HIV Protease Inhibitors