title: Decreased striatal dopaminergic innervation in REM sleep behavior disorder.
abstract: REM sleep behavior disorder (RBD) is a possible herald of neurodegenerative disorders with parkinsonism. The authors determined the density of striatal dopaminergic terminals with [11C]dihydrotetrabenazine PET in six elderly subjects with chronic idiopathic RBD and 19 age-appropriate controls. In subjects with RBD, there were significant reductions in striatal [11C]dihydrotetrabenazine binding, particularly in the posterior putamen.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, USA. ralbin@umich.edu
authors.forename: R L
authors.initials: RL
authors.lastname: Albin
authors.forename: R A
authors.initials: RA
authors.lastname: Koeppe
authors.forename: R D
authors.initials: RD
authors.lastname: Chervin
authors.forename: F B
authors.initials: FB
authors.lastname: Consens
authors.forename: K
authors.initials: K
authors.lastname: Wernette
authors.forename: K A
authors.initials: KA
authors.lastname: Frey
authors.forename: M S
authors.initials: MS
authors.lastname: Aldrich
mesh_terms: D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D004298:Dopamine / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020187:REM Sleep Behavior Disorder / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
chemical_list: D004298:Dopamine