Molecular structure and cytotoxicity of 3D-transition metal complexes capable to form a stable metal-nitrogen bond.
The cytotoxicity of several Co(II), Ni(II), Cu(II) and Zn(II) complexes with various molecular structures and geometries, has been tested on LoVo and 2008 cells at 1-100 microM concentration for 24 h exposure. On the basis of 24 h results, the exposure time was prolonged to 48 and to 72 hours. The most potent complexes result [Cu(tren)(H2O)]2+ 2Cl-, E, [CoCl3(H2Meppz)], G, and [CoCl3(HMe2ppz)], H, (tren=tris(2-aminoethyl)amine, H2Meppz=1-methylpiperazin-1-ium, HMe2ppz=1,4-dimethylpiperazin-1-ium cations). Nevertheless, these complexes are able to induce cell growth reduction of about 50% at highest doses tested (1-100 microM ) and after 72 h exposure.
Marzotto
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A
Department of Inorganic, Metallorganic and Analytical Chemistry, University of Padova, Italy. marzotto@chim02.chin.unipd.it
Clemente
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DA
Zampiron
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A
Carrara
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M
D000230:Adenocarcinoma / Q000473:pathology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000473:pathology; D005260:Female; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010051:Ovarian Neoplasms / Q000473:pathology; D010084:Oxidation-Reduction; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
C421450:(6,8,15,17-tetramethyldibenzo-5,9,14,18-tetraazacyclotetradecene)nickel(II); D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D009942:Organometallic Compounds; D010879:Piperazines; C421449:diaqua(hemiporphyrazine)cobalt(II); C421452:trichloro(1,4-dimethylpiperazin-1-ium)cobalt(II); C421451:trichloro(1-methylpiperazin-1-ium)cobalt(II)