Hantavirus pulmonary syndrome associated with Monongahela virus, Pennsylvania.
The first two recognized cases of rapidly fatal hantavirus pulmonary syndrome in Pennsylvania occurred within an 8-month period in 1997. Illness in the two patients was confirmed by immunohistochemical techniques on autopsy material. Reverse transcription-polymerase chain reaction analysis of tissue from one patient and environmentally associated Peromyscus leucopus (white-footed mouse) identified the Monongahela virus variant. Physicians should be vigilant for such Monongahela virus-associated cases in the eastern United States and Canada, particularly in the Appalachian region.
Rhodes
L V
LV
Lehigh Valley Hospital, Allentown, Pennsylvania, USA. luther.rhodes@lvh.com
Huang
C
C
Sanchez
A J
AJ
Nichol
S T
ST
Zaki
S R
SR
Ksiazek
T G
TG
Humphreys
J G
JG
Freeman
J J
JJ
Knecht
K R
KR
D000328:Adult; D000818:Animals; D005260:Female; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D018778:Hantavirus Infections / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008168:Lung / Q000821:virology; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D010414:Pennsylvania; D010542:Peromyscus / Q000821:virology