title: Antenatal predictors of the neurologic sequelae at 3 years of age: a multivariate analysis.
abstract: OBJECTIVE
  To study the association between fetal blood flow abnormalities and the occurrence of long-term neurologic sequelae.
  
  
  METHODS
  Umbilical, aortic and middle cerebral artery blood flow parameters were obtained by Doppler examination and retrospectively analyzed in 128 high-risk singleton pregnancies, followed by neurologic examination of the surviving children at 3 years of age. Traditional parameters of neurologic outcome (Apgar scores, intrauterine growth retardation (IUGR), umbilical artery pH and base deficit, gestational age, birth weight, newborn encephalopathy, mode of delivery, fetal heart rate, neurosonographic examination) were included as possible confounding factors. Mann-Whitney U-test, Student's t-test, analysis of variance or Fisher's exact test, where applicable, were used for the univariate analysis. A stepwise logistic regression procedure was conducted to test the independent association of selected perinatal risk factors on neurological outcome. Statistical significance was assumed at P<0.05.
  
  
  RESULTS
  Eighteen out of 114 surviving children suffered neurologic illness at 3 years of age. Four children had major neurologic dysfunction and the remaining 14 suffered minor or mild form of the disease. Although blood flow parameters and various perinatal parameters did not differ significantly between the group of children with major neurologic dysfunction and healthy children, aortic resistance index showed an independent association with occurrence of minor or mild neurologic disabilities.
  
  
  CONCLUSIONS
  Antenatal evaluation of the aortic blood flow might be an important predictive variable for permanent neurologic disturbances.
authors.affiliation: Department of Perinatal Medicine, Zagreb University School of Medicine, Petrova 13, HR-10000 Zagreb, Croatia. ivan.kuvacic@zg.tel.hr
authors.forename: S
authors.initials: S
authors.lastname: Skrablin
authors.forename: D
authors.initials: D
authors.lastname: Kalafatić
authors.forename: I
authors.initials: I
authors.lastname: Banović
authors.forename: I
authors.initials: I
authors.lastname: Kuvacić
authors.forename: E
authors.initials: E
authors.lastname: Juretić
authors.forename: T
authors.initials: T
authors.lastname: Goluza
mesh_terms: D001034:Apgar Score; D001783:Blood Flow Velocity; D001927:Brain Diseases / Q000209:etiology*; D002675:Child, Preschool; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D005311:Fetal Hypoxia / Q000150:complications*; D005333:Fetus / Q000098:blood supply*; D006801:Humans; D015999:Multivariate Analysis; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors