Hoxa4 expression in developing mouse hair follicles and skin.
We have examined the expression of the Hoxa4 gene in embryonic vibrissae and developing and cycling postnatal pelage hair follicles by digoxigenin-based in situ hybridization. Hoxa4 expression is first seen in E13.5 vibrissae throughout the follicle placode. From E15.5 to E18.5 its expression is restricted to Henle's layer of the inner root sheath. Postnatally, Hoxa4 expression is observed at all stages of developing pelage follicles, from P0 to P4. Sites of expression include both inner and outer root sheaths, matrix cells, and the interfollicular epidermis. Hoxa4 is not expressed in hair follicles after P4. Hoxb4, however, is expressed both in developing follicles at P2 and in catagen at P19, suggesting differential expression of these two paralogous genes in the hair follicle cycle.
Packer
A I
AI
Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA.
Jane-Wit
D
D
McLean
L
L
Panteleyev
A A
AA
Christiano
A M
AM
Wolgemuth
D J
DJ
D000818:Animals; D004268:DNA-Binding Proteins; D004817:Epidermis / Q000196:embryology; D015870:Gene Expression; D006197:Hair / Q000196:embryology*; D018398:Homeodomain Proteins / Q000096:biosynthesis* / Q000235:genetics*; D017403:In Situ Hybridization; D051379:Mice; D012867:Skin / Q000196:embryology*; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C484111:Hoxa4 protein, mouse; C513262:Hoxb4 protein, mouse; D014157:Transcription Factors