title: A national confidential enquiry into community acquired pneumonia deaths in young adults in England and Wales. British Thoracic Society Research Committee and Public Health Laboratory Service.
abstract: BACKGROUND
  The aim of this study was to describe the frequency, causal pathogens, management, and outcome of a population of young adults who died from community acquired pneumonia (CAP).
  
  
  METHODS
  Pneumonia deaths in England and Wales in adults aged 15-44 were identified between September 1995 and August 1996. Patients with underlying chronic illness including HIV infection were excluded. Clinical details for each case were collected from the hospital and general practitioner records.
  
  
  RESULTS
  Death from CAP was identified in 27 previously well young adults (1.2 per million population per year). Twenty were known to have consulted a GP for this illness. Nine received antibiotics before hospital admission. A causative pathogen was identified in 17 cases (Streptococcus pneumoniae in eight). Bacteraemia was present in seven. All patients who reached a hospital ward received antibiotics (69% within two hours of admission). The British Thoracic Society antibiotic guidelines for severe CAP were followed in only 10 cases. Cardiac arrest at home or on arrival at hospital occurred in six cases, one of whom was successfully resuscitated. Of the remaining 21 patients, 71% had two or more markers of severe CAP. All 22 who were admitted reached an intensive care unit, but 11 of these required transfer to another hospital for some aspect of intensive care. One third of patients died within 24 hours of presenting to the hospital.
  
  
  CONCLUSIONS
  Death from CAP in previously fit young adults still occurs. While some deaths might be preventable by better patient management, most are unlikely to be preventable by current management practices.
authors.affiliation: Stepping Hill Hospital, Stockport SK7 2JE, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Simpson
authors.forename: J T
authors.initials: JT
authors.lastname: Macfarlane
authors.forename: J
authors.initials: J
authors.lastname: Watson
authors.forename: M A
authors.initials: MA
authors.lastname: Woodhead
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D003644:Death Certificates; D004739:England / Q000453:epidemiology; D005194:Family Practice; D005260:Female; D006306:Health Surveys; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D014852:Wales / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents