title: Cerebral oxygenation in the traumatically brain-injured patient: are ICP and CPP enough?
abstract: Secondary brain injury results in increased morbidity and mortality in the traumatically brain-injured (TBI) patient. Research has shown that prevention of secondary brain injury, as characterized by cerebral ischemia and edema, can improve neurologic outcomes. The standard of care in many facilities is to monitor intracranial pressure and cerebral perfusion pressure as indirect measures of cerebral oxygenation and perfusion and to therefore manage secondary brain injury via these parameters. Yet these may not be the most accurate or reliable measures of cerebral oxygenation. Scientifically, brain tissue oxygenation can be directly measured via the partial pressure of oxygen in brain tissue (PbO2) probe. This provides a rapid, potentially more accurate indicator of cerebral oxygenation, thereby allowing for earlier intervention into the prevention of secondary brain injury.
authors.affiliation: Department of Adult Health Nursing, School of Nursing, University of Maryland, Baltimore 21201, USA.
authors.forename: G
authors.initials: G
authors.lastname: Hilton
mesh_terms: D001784:Blood Gas Analysis; D001921:Brain / Q000098:blood supply* / Q000378:metabolism*; D001930:Brain Injuries / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D007427:Intracranial Pressure; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010313:Partial Pressure
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen