title: Potential harmful effect of iodinated intravenous contrast medium on the clinical course of mild acute pancreatitis.
abstract: OBJECTIVE
  A worse clinical outcome might be expected in patients with acute pancreatitis (AP) who receive intravenous contrast medium for a nondynamic contrast-enhanced computed tomographic (CECT) study early during hospital admission.
  
  
  METHODS
  Cohort analytic study.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  Of 126 patients with mild AP, 52 patients underwent CECT to establish AP diagnosis (group 1), and the remaining 74 did not (group 2).
  
  
  METHODS
  Survival and development of local or systemic complications during the hospital stay. Potential confounders were demographic, clinical, and biochemical data, as well as therapeutic measures. The Atlanta classification was used to define local and systemic complications.
  
  
  RESULTS
  Mean age, etiology of AP, prognostic score on admission, and pharmacologic treatment were similar between groups. Local and systemic complications were more frequently observed in patients who underwent CECT (odds ratio, 11.4; 95% confidence interval, 2.0-64.8; P =.008). Six patients, all in group 1, developed a pancreatic abscess (odds ratio, 20.8; P =.004). In 5 of them, a second CECT showed more severe AP changes. The association between CECT and abscess development was more apparent in patients with a body mass index of 25 or more and/or nasogastric suction. Six patients in group 1 and 1 in group 2 had systemic complications (odds ratio, 9. 5; P =.01). There were no deaths.
  
  
  CONCLUSIONS
  The observed increased incidence of local and systemic complications in patients with mild AP who undergo CECT, particularly in those with a body mass index of 25 or more, suggests a potentially harmful effect of intravenous contrast medium. Until this issue is clarified, it seems reasonable to restrict the use of dynamic CECT to patients with severe AP, protracted clinical course, or suspected local septic complication.
authors.affiliation: Dirección de Enseñanza, Instituto Nacional de la Nutrición Salvador Zubirán, Tlalpan, México, DF 14000, México.
authors.forename: R
authors.initials: R
authors.lastname: Carmona-Sánchez
authors.forename: L
authors.initials: L
authors.lastname: Uscanga
authors.forename: P
authors.initials: P
authors.lastname: Bezaury-Rivas
authors.forename: G
authors.initials: G
authors.lastname: Robles-Díaz
authors.forename: J
authors.initials: J
authors.lastname: Suazo-Barahona
authors.forename: F
authors.initials: F
authors.lastname: Vargas-Vorácková
mesh_terms: D000208:Acute Disease; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007483:Iothalamic Acid / Q000009:adverse effects*; D008297:Male; D010195:Pancreatitis / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D007483:Iothalamic Acid