title: Different manifestations of langerhans cell histiocytosis affecting two members of a family.
abstract: Two different manifestations of Langerhans cell histiocytosis (histiocytosis X) are presented, the first occurring as a solitary rib eosinophil granuloma in an 11-year-old girl, and the second as an eosinophil granuloma of the lung of her mother, a 41-year-old heavy smoker, appearing 8 years after the onset of her daughter's disease. Familial clustering of two different manifestations of histiocytosis X disease is very rare and raises the possibility of inherited mutations that promote emergence of clonal Langerhans cells.
authors.affiliation: Department of Respiratory Medicine, County Hospital, University Medical School, Pécs, Hungary. chelonae@mail.matav.hu
authors.forename: Z
authors.initials: Z
authors.lastname: Balikó
authors.forename: M
authors.initials: M
authors.lastname: Schreiner
authors.forename: K K
authors.initials: KK
authors.lastname: Kishindy
authors.forename: G
authors.initials: G
authors.lastname: Hegedüs
authors.forename: G
authors.initials: G
authors.lastname: Kosztolányi
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D006680:HLA Antigens; D006646:Histiocytosis, Langerhans-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology
chemical_list: D006680:HLA Antigens