title: Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells.
abstract: Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell-cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.
authors.affiliation: Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11042, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Meng
authors.forename: I D
authors.initials: ID
authors.lastname: Goldberg
authors.forename: E M
authors.initials: EM
authors.lastname: Rosen
authors.forename: S
authors.initials: S
authors.lastname: Fan
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology* / Q000517:prevention & control; D015820:Cadherins / Q000032:analysis; D002448:Cell Adhesion; D002465:Cell Movement; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D009361:Neoplasm Invasiveness; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins
chemical_list: D016588:Anticarcinogenic Agents; D015820:Cadherins; D007211:Indoles; D025521:Tumor Suppressor Proteins; C016517:indole-3-carbinol; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human