[In vivo studies of the inhbitory effect of various food components on aflatoxin B1 metabolism].
Possible interferences with aflatoxin B1 metabolism, of some compounds naturally present in food (quercetin, beta-naphthoflavone), resulting from way of cooking method (2-aminodipyrido [1,2-a; 1',2'-d] imidazole (Glu-P-2), norharmane; NH) or used as food additives (butylated hydroxytoluene; BHT) have been studied in vivo by evaluating the production of adducts to glutathione and adducts to serum proteins in laboratory rats. Glu-P-2 and norharmane inhibit strongly the production of adducts to glutathione whereas quercetin and beta-naphthoflavone have only a low effect. BHT is completely ineffective. The adducts to proteins are inhibited by the five compounds, norharmane being the most efficient.
Ngombo
M
M
Unité de Mutagenèse et Tératogenèse, UCL 72.37, Bruxelles, Belgique.
Rollmann
B
B
de Meester
C
C
Léonard
A
A
D016604:Aflatoxin B1 / Q000493:pharmacokinetics*; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D001798:Blood Proteins / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002243:Carbolines; D002274:Carcinogens, Environmental / Q000493:pharmacokinetics*; D005503:Food Additives / Q000494:pharmacology*; D005511:Food Handling; D005978:Glutathione / Q000187:drug effects; D006247:Harmine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D019324:beta-Naphthoflavone / Q000494:pharmacology*
D001798:Blood Proteins; D002243:Carbolines; D002274:Carcinogens, Environmental; D005503:Food Additives; D007093:Imidazoles; D002084:Butylated Hydroxytoluene; D006247:Harmine; D019324:beta-Naphthoflavone; C010262:norharman; D011794:Quercetin; D016604:Aflatoxin B1; D005978:Glutathione; C023847:Glu-P-2