title: Glutathione S-transferase pi gene methylation: the search for a molecular marker of prostatic adenocarcinoma.
abstract: Glutathione S-transferase pi gene methylation has recently been described in prostatic adenocarcinoma. Aggregate data on 115 samples studied to date have found an 87% sensitivity and 92% specificity for prostate cancer diagnosis. The current literature about this new marker is herein summarized, and possible molecular mechanisms by which glutathione S-transferase pi may participate in prostatic carcinogenesis are reviewed. The possible clinical implications of this molecular alteration in the diagnosis of prostatic adenocarcinoma are also studied.
authors.affiliation: Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Jimenez
authors.forename: A H
authors.initials: AH
authors.lastname: Fischer
authors.forename: J A
authors.initials: JA
authors.lastname: Petros
authors.forename: M B
authors.initials: MB
authors.lastname: Amin
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology*; D000483:Alleles; D019175:DNA Methylation; D005819:Genetic Markers; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D008297:Male; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000201:enzymology*
chemical_list: D005819:Genetic Markers; D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase