Lithium-induced increase in human brain grey matter.
Rodent studies have shown that lithium exerts neurotrophic or neuroprotective effects. We used three-dimensional magnetic resonance imaging and brain segmentation to study pharmacologically-induced increases in grey matter volume with chronic lithium use in patients with bipolar mood disorder. Grey-matter volume increased after 4 weeks of treatment. The increases in grey matter probably occurred because of neurotrophic effects.
Moore
G J
GJ
Bebchuk
J M
JM
Wilds
I B
IB
Chen
G
G
Manji
H K
HK
Menji
H K
HK
D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000187:drug effects / Q000378:metabolism; D001714:Bipolar Disorder / Q000188:drug therapy*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use
D018696:Neuroprotective Agents; D001224:Aspartic Acid; C000179:N-acetylaspartate; D008094:Lithium