title: Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside.
abstract: Flaxseed and its lignan secoisolariciresinol diglycoside (SDG) inhibit mammary tumor development in rats. Increased plasma insulin-like growth factor I (IGF-I) concentrations are associated with increased breast cancer risk. Therefore, the effect of flaxseed (5%) or SDG (1.5 mg/day) supplementation on plasma IGF-I levels was examined in rats treated with or without N-methyl-N-nitrosourea (MNU). In MNU-free rats, flaxseed and SDG reduced plasma IGF-I levels, which were inversely related to urinary lignan excretion. Only flaxseed significantly reduced plasma IGF-I concentrations in MNU-treated rats. The anticancer effect of flaxseed and SDG may be related, in part, to reductions in plasma IGF-I.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Ontario M5S 3E2, Toronto, Canada.
authors.forename: S E
authors.initials: SE
authors.lastname: Rickard
authors.forename: Y V
authors.initials: YV
authors.lastname: Yuan
authors.forename: L U
authors.initials: LU
authors.lastname: Thompson
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002072:Butylene Glycols / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity; D019587:Dietary Supplements; D004435:Eating / Q000187:drug effects; D005260:Female; D019597:Flax; D005960:Glucosides / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D017705:Lignans / Q000096:biosynthesis / Q000652:urine; D008321:Mammary Glands, Animal / Q000187:drug effects; D008770:Methylnitrosourea / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016588:Anticarcinogenic Agents; D002072:Butylene Glycols; D002273:Carcinogens; D005960:Glucosides; D017705:Lignans; D007334:Insulin-Like Growth Factor I; D008770:Methylnitrosourea; C090142:secoisolariciresinol diglucoside