title: Expression of bcl-2 Protein in Breast Carcinoma with Correlation to Expression of p53 Protein and Clinicopathological Factors.
abstract: Expression of bcl-2 gene product was examined in 204 breast carcinomas in order to ascertain its clinicopathological significance. The bcl-2 protein was detected by immunohistochemistry on paraffin embedded tissue sections and its presence was confirmed by Western blot analysis of whole cell lysates. A strong positive correlation was noted among expression of bcl-2 protein in carcinoma cells, positivity of progesterone receptor (PR) and expression of p53 protein. However, no correlation could be observed among expression of bcl-2 protein, histological type of carcinoma, tumor size, lymph node metastasis and positivity of estrogen receptor (ER).
authors.affiliation: Second Department of Pathology, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734, Japan.
authors.initials: B
authors.lastname: Kumaravel
authors.initials: K
authors.lastname: Arihiro
authors.initials: M
authors.lastname: Kaneko
authors.initials: S
authors.lastname: Fujii
authors.initials: K
authors.lastname: Inai