Hepatotoxic effect of metallic pollutants on enzyme histochemical activities of yellow-legged gull Larus cachinnans michahellis liver.
We studied the hepatotoxic effect of heavy metals (cadmium, mercury, copper) on Mg2+ -ATPase, NADH diaphorase, succinic dehydrogenase and acid phosphatase of yellow-legged gull liver, using enzyme histochemical methods. The lysosomal enzyme activity of acid phosphatase was increased in all cases. However, the other enzyme activities appeared to be insensitive to the different metallic pollutants and to their respective levels, in contrast with literature experimental data showing plasma membrane and mitochondrial alterations. This controversy could be explained by the differences in dietary conditions and metal overloads. The molecular basis of the toxicities of metallic pollutants is discussed.
Benkoel
L
L
Laboratoire de Pathologie Cellulaire et Métabolique du Foie, INSERM U 260, Faculté de Médecine, Marseille, France.
Dodero
F
F
Roussel
E
E
Baudin
J C
JC
Lambert
R
R
Chamlian
A
A
Augier
H
H
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001717:Birds; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D002104:Cadmium / Q000032:analysis / Q000633:toxicity; D003300:Copper / Q000032:analysis / Q000633:toxicity; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D004785:Environmental Pollutants / Q000032:analysis / Q000633:toxicity*; D006651:Histocytochemistry; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology* / Q000473:pathology; D008628:Mercury / Q000032:analysis / Q000633:toxicity; D019216:Metals, Heavy / Q000032:analysis / Q000633:toxicity*; D013054:Spectrophotometry, Atomic; D013385:Succinate Dehydrogenase / Q000378:metabolism
D004785:Environmental Pollutants; D019216:Metals, Heavy; D002104:Cadmium; D003300:Copper; D013385:Succinate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase; D000135:Acid Phosphatase; D017301:Ca(2+) Mg(2+)-ATPase; D008628:Mercury