A new three-carbon synthon for efficient synthesis of benzannelated and 1-(2-arylethenyl) heterocycles
The novel three-carbon synthon 1-(1H-1,2, 3-benzotriazol-1-yl)-3-chloroacetone for the synthesis of benzothiazoles, pyrido[1,2-a]indoles, and styryl-substituted indolizines and imidazo[1,2-a]pyridines is reported. The proposed routes are a general and efficient approach for heterocyclizations followed by benzannelations or attachment of arylethenyl pharmacophores.
Katritzky
AR
Center for Heterocyclic Compounds, University of Florida, Department of Chemistry, Gainesville, Florida 32611-7200, Bristol Myers Squibb Co., Pharmaceutical Research Institute, Route 206 & Provinceline Road, Princeton, New Jersey 08563, and Bristol.
Tymoshenko
DO
Monteux
D
Vvedensky
V
Nikonov
G
Cooper
CB
Deshpande
M