A short catalytic enantioselective synthesis of the vascular antiinflammatory eicosanoid (11R,12S)-oxidoarachidonic acid.
[reaction: see text] An effective pathway is described for the synthesis of (11R, 12S)-oxidoarachidonic acid (1) from the achiral precursors shown.
Han
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X
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Crane
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SN
Corey
E J
EJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry; D001095:Arachidonic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002318:Cardiovascular Diseases / Q000503:physiopathology; D002384:Catalysis; D006801:Humans; D007249:Inflammation; D013237:Stereoisomerism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids