title: The synthesis of novel 6,5- and 6,6-membered fused heterocyclic compounds derived from thymine.
abstract: Novel pyrimido[1,2-a]pyrimidinones 14, 15 and 16 and imidazo[1,2-a] pyrimidinones 19 and 20, designed as conformationally constrained analogues of 1-(3-amino-2-hydroxypropyl)thymine and 1-(2-amino-3-hydroxypropyl)thymine, respective ly, were synthesized by the ring-opening/ ring-closure rearrangement of the corresponding byciclic oxygen-containing amino compounds 12 and 17.
authors.affiliation: Ruder Bosković Institute, Department of Organic Chemistry and Biochemistry, Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Jokić
authors.forename: Z
authors.initials: Z
authors.lastname: Raza
authors.forename: D
authors.initials: D
authors.lastname: Katalenić
mesh_terms: D015195:Drug Design; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D011741:Pyrimidine Nucleosides / Q000737:chemistry*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry*; D013941:Thymine / Q000737:chemistry*
chemical_list: D011725:Pyridines; D011741:Pyrimidine Nucleosides; D011744:Pyrimidinones; C001439:imidazo(1,2-a)pyridine; D013941:Thymine