Clathculins A and B, two novel nitrogen-containing metabolites from the sponge Clathrina aff. reticulum.
Two novel acyclic diaza alkenynes, clathculins A and B (1 and 2), were isolated from the Indo-Pacific sponge Clathrina aff. reticulum collected in Sodwana Bay, South Africa. The structure of the mixture of the two unstable inseparable compounds was established by spectroscopic analysis, mainly 1D and 2D NMR measurements and two chemical transformations. Clathculins A and B are the first reported linear marine metabolites containing a 1,2-diaminoethane moiety.
Rudi
A
A
School of Chemistry, Tel-Aviv University, Ramat Aviv 69978, Israel.
Schleyer
M
M
Kashman
Y
Y
D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D001372:Aza Compounds / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
D000480:Alkynes; D001372:Aza Compounds; C416583:clathculin A; C416584:clathculin B