Increased skin lactate in complex regional pain syndrome: evidence for tissue hypoxia?
To investigate oxygen metabolism in complex regional pain syndrome (CRPS), the authors measured skin lactate via dermal microdialysis performed on patients with CRPS (n = 11) and healthy control subjects (n = 11). In addition, they measured blood lactate. Although venous lactate was unaltered, skin lactate was increased in patients with CRPS (2.95 mmol/L; control subjects 1.74 mmol/L; p < 0.005). These results suggest enhanced anaerobic glycolysis, probably as a result of chronic tissue hypoxia.
Birklein
F
F
Neurologische Klinik, Friedrich-Alexander-Universität Erlangen, Germany. birklein@physiologie1.uni-erlangen.de
Weber
M
M
Neundörfer
B
B
D000328:Adult; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D012019:Reflex Sympathetic Dystrophy / Q000097:blood / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*
D019344:Lactic Acid