[Role of drugs in recovery from brain damage].
The mechanisms that enhance recovery from brain lesion are more and more precise. The role of neurotransmitters and post-synaptic receptors are essential. Different drugs acting at the level of synapses are potentially useful but still few used in neurorehabilitation. The aim of this article is to review the drugs that can be prescribed in selected situation. In spite of encouraging results of numerous studies, a lot of questions remain and prove the need of large randomised studies to determine the real benefit of drugs in rehabilitation. Moreover, if the activation of neurotransmitters can improve recovery, all their antagonists will produce the inverse effect. Therefore, the choice of drugs in neurorehabilitation is essential.
Vuadens
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Clinique romande de réadaptation, Sion.
D000662:Amphetamines / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001930:Brain Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000534:rehabilitation*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D020127:Recovery of Function / Q000187:drug effects*; D020521:Stroke / Q000188:drug therapy; D000071939:Stroke Rehabilitation
D000662:Amphetamines; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D000697:Central Nervous System Stimulants; D018680:Cholinergic Antagonists; D018491:Dopamine Agonists; D005938:Glucocorticoids; D018377:Neurotransmitter Agents