title: Intracranial ependymomas of childhood: current management strategies.
abstract: Children with intracranial ependymomas have relatively poor outcomes despite the low-grade histology of these tumors and recent advances in diagnosis, microneurosurgical resection, and adjuvant therapy. Aggressive surgical resection and postoperative adjuvant therapy result in only a 5-year survival rate of 50%. In this paper, we provide a review of the current technical aspects of surgical resection, and focus on recent studies of the epidemiology, molecular markers, prognostic factors and adjuvant therapy for childhood intracranial ependymomas and discuss their implications for current and future management strategies.
authors.affiliation: Department of Neurological Surgery, University of California, San Francisco, CA 94143-0112, USA. smythm@neurosurg.ucsf.edu
authors.forename: M D
authors.initials: MD
authors.lastname: Smyth
authors.forename: B N
authors.initials: BN
authors.lastname: Horn
authors.forename: C
authors.initials: C
authors.lastname: Russo
authors.forename: M S
authors.initials: MS
authors.lastname: Berger
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D018572:Disease-Free Survival; D004806:Ependymoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D005819:Genetic Markers; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome
chemical_list: D005819:Genetic Markers