title: A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.
abstract: Leukocyte chemoattractants are involved in the inflammatory response act via G protein-coupled receptors. We report the cloning of a novel human gene encoding the putative orphan receptor, C5L2, belonging to a subfamily of C3a, C5a and formyl Met-Leu-Ph receptors that are related to the chemokine receptor family. C5L2 transcript levels were abundant in granulocytes and immature dendritic cells but not in mature dendritic cells. We speculate that this receptor may regulate the activation of immature dendritic cells and play a role in the chemoattraction of leukocytes to inflammatory regions.
authors.affiliation: The Second Research Department, Central Technology Laboratory, Asahi Chemical Industry Co., Ltd., Samejima 2-1, Fuji-shi, Shizuoka 416-8501, Japan. ohno.md@om.asahi-kasei.co.jp
authors.forename: M
authors.initials: M
authors.lastname: Ohno
authors.forename: T
authors.initials: T
authors.lastname: Hirata
authors.forename: M
authors.initials: M
authors.lastname: Enomoto
authors.forename: T
authors.initials: T
authors.lastname: Araki
authors.forename: H
authors.initials: H
authors.lastname: Ishimaru
authors.forename: T A
authors.initials: TA
authors.lastname: Takahashi
mesh_terms: D000595:Amino Acid Sequence; D000906:Antibodies; D002454:Cell Differentiation; D002460:Cell Line; D003001:Cloning, Molecular; D003713:Dendritic Cells / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism*; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D006098:Granulocytes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D044087:Receptor, Anaphylatoxin C5a; D019707:Receptors, Chemokine / Q000032:analysis* / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment; D014162:Transfection
chemical_list: D000906:Antibodies; C417003:C5aR2 protein, human; D012333:RNA, Messenger; D044087:Receptor, Anaphylatoxin C5a; D019707:Receptors, Chemokine