title: Periodic lateralized epileptiform discharges (PLEDs) as early indicator of stroke in full-term newborns.
abstract: We report on periodic lateralized epileptiform discharges (PLEDs) on EEG in two infants with neonatal convulsions. In both neonates, the EEG abnormalities were seen soon after the onset of seizures, at a time when cranial ultrasound scans were thought to be normal. Subsequent Magnetic Resonance Imaging scans demonstrated cerebral infarction in both patients. In one case, the localisation of the lesion on MRI was concordant with that of the EEG abnormalities, as usually observed in adults with focal lesions. The other infant showed similar EEG abnormalities, but her MRI showed a localised lesion in the basal ganglia, which has also been reported to be involved in the genesis of these abnormalities.
authors.affiliation: Child Neurology and Psychiatry Unit, Catholic University, Rome, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Randò
authors.forename: D
authors.initials: D
authors.lastname: Ricci
authors.forename: E
authors.initials: E
authors.lastname: Mercuri
authors.forename: M F
authors.initials: MF
authors.lastname: Frisone
authors.forename: R
authors.initials: R
authors.lastname: Luciano
authors.forename: G
authors.initials: G
authors.lastname: Tortorolo
authors.forename: F
authors.initials: F
authors.lastname: Guzzetta
mesh_terms: D001132:Arm / Q000503:physiopathology; D001921:Brain / Q000473:pathology; D004569:Electroencephalography; D004576:Electromyography; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology; D010507:Periodicity; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000175:diagnosis*