title: Squamous cell carcinoma of the nasal planum in 17 dogs.
abstract: Squamous cell carcinoma of the nasal planum was diagnosed in 17 dogs over a period of 11 years. Ulceration, bleeding and sneezing were the most common clinical signs. One dog had cytological evidence of metastasis to the local lymph node. The dogs were treated by surgical resection, fractionated megavoltage irradiation, or a combination of the two. Surgical resection gave the most favourable results; four of six dogs were cured but a recurrence of the tumour was predicted in the other two on the basis of incomplete or marginal resection. Radiotherapy alone was not as effective; one of four dogs was cured, and the tumour recurred in the others within 24 weeks (median eight weeks). Combined surgical resection and radiotherapy did not produce a cure in any of the seven remaining dogs, and the tumour recurred within 12 weeks (median nine weeks). Three dogs had cytological evidence of lymph node metastasis when the tumour recurred. The dogs' prognosis was adversely affected by the interval between their initial examination and treatment, but there was no apparent association between the histological grade of the tumour and the clinical outcome.
authors.affiliation: Queen's Veterinary School Hospital, Department of Clinical Veterinary Science, University of Cambridge.
authors.forename: B D
authors.initials: BD
authors.lastname: Lascelles
authors.forename: A T
authors.initials: AT
authors.lastname: Parry
authors.forename: M F
authors.initials: MF
authors.lastname: Stidworthy
authors.forename: J M
authors.initials: JM
authors.lastname: Dobson
authors.forename: R A
authors.initials: RA
authors.lastname: White
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D004285:Dogs; D005260:Female; D008297:Male; D009669:Nose Neoplasms / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D018714:Radiotherapy, Adjuvant / Q000662:veterinary; D012189:Retrospective Studies; D016896:Treatment Outcome