title: 18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies.
abstract: Using (18)F-fluorodopa PET and a constant 0.0062 influx rate in the putamen, dementia with Lewy bodies (n = 7) was distinguished from AD (n = 10) with a sensitivity of 86% and a specificity of 100%. A constant 0.0071 influx rate in the caudate yielded a sensitivity of 71% and a specificity of 100% for distinction of the two disorders. Despite a limited sample size, these findings suggest that assessing nigrostriatal dopaminergic function with (18)F-fluorodopa PET may be a useful diagnostic aid in cases of dementia with Lewy bodies while patients are alive.
authors.affiliation: Department of Geriatric Medicine, Tohoku University School of Medicine, and the Cyclotron and Radioisotope Center , Tohoku University, Sendai, Miyagi, Japan.
authors.forename: X S
authors.initials: XS
authors.lastname: Hu
authors.forename: N
authors.initials: N
authors.lastname: Okamura
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Higuchi
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: M
authors.initials: M
authors.lastname: Tashiro
authors.forename: M
authors.initials: M
authors.lastname: Shinkawa
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008875:Middle Aged; D014055:Tomography, Emission-Computed
chemical_list: C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine; D004298:Dopamine