Anti-inflammatory activity of the hydrosoluble fraction of Euphorbia royleana latex.
The hydrosoluble fraction of Euphorbia royleana latex (AER), administered by gavage at doses of 50-200 mg/kg, showed dose-dependent anti-inflammatory and anti-arthritic effects in different acute and chronic test models in rats and mice. It reduced the exudate volume and the migration of leukocytes and showed a poor inhibitory effect on the granuloma formation induced by cotton pellets, while it had a low ulcerogenic score. The oral LD(50) was more than 1500 mg/kg in both rats and mice.
Bani
S
S
Department of Pharmacology, Regional Research Laboratory, Canal Road, Jammu, India.
Kaul
A
A
Jaggi
B S
BS
Suri
K A
KA
Suri
O P
OP
Sharma
O P
OP
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy*; D019665:Euphorbiaceae; D006614:Hindlimb / Q000187:drug effects; D007840:Latex / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007840:Latex; D010936:Plant Extracts