Decline of language among women and men with Alzheimer's disease.
Previous research raises the possibility that gender differences occur in language function in Alzheimer's disease, but this hypothesis has not been evaluated systematically in longitudinal studies. The authors examined the association of gender with rate of decline in language and other cognitive functions among 410 persons with Alzheimer's disease. Participants were recruited from a dementia clinic and followed for up to 5 annual evaluations. Follow-up participation among survivors exceeded 90%. Decline in a composite score based on 8 language tests was evaluated in random effects models with age, education, and race controlled. Annual decline was 0.71 standard units (95% confidence interval [CI] = 0.62-0.79) for women and 0.74 units (95% CI = 0.61-0.86) for men, not a significant difference. Decline on the individual language tests and on composite measures of memory, perception, and global cognition also indicated no significant association with gender. These results suggest that Alzheimer's disease affects language and other cognitive functions similarly in women and men.
Hebert
L E
LE
Rush Institute for Healthy Aging and Department of Medicine, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA. LHebert1@rush.edu
Wilson
R S
RS
Gilley
D W
DW
Beckett
L A
LA
Scherr
P A
PA
Bennett
D A
DA
Evans
D A
DA
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis; D018450:Disease Progression; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis / Q000209:etiology*; D007807:Language Tests; D008136:Longevity; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012727:Sex Characteristics; D013997:Time Factors