Ipsapirone suppresses food intake in food-deprived rats by an action at 5-HT(1A) receptors.
The effects of the 5-HT(1A) receptor agonist ipsapirone (2.5-10 mg/kg, s.c.) on food intake were investigated in rats that had been fasted for 22 h. Ipsapirone administered immediately prior to presentation of food produced a dose-related decrease in food intake. The effect of ipsapirone (5 mg/kg) was reversed by pretreatment with the 5-HT(1A) receptor antagonist N-[2[4-)2-methoxyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexaneca rboxamide trihydrochloride (WAY100635) (0.3 mg/kg, s.c.). The results of this study show that ipsapirone has acute dose-dependent depressant effects on food intake in fasted rats, mediated by 5-HT(1A) receptors.
Arkle
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Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Hampshire, PO1 2DT, England, UK.
Ebenezer
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
D010879:Piperazines; D011725:Pyridines; D011743:Pyrimidines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C043077:ipsapirone; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide