Hyperleptinemia is not correlated with markers of protein malnutrition in chronic renal failure. A cross-sectional study in predialysis, peritoneal dialysis and hemodialysis patients.
BACKGROUND
Serum leptin levels are increased in chronic renal failure (CRF) and may potentially contribute to protein malnutrition in this disorder.


METHODS
Following a cross-sectional design, we performed a nutritional survey in a wide sample of uremic patients treated conservatively (n = 87), with peritoneal dialysis (n = 71) and with hemodialysis (n = 53). Then, we analyzed the correlation between serum leptin levels and markers of protein malnutrition. We used a multivariate approach, taking into consideration the confounding effect of other factors on the correlation between hyperleptinemia and protein malnutrition.


RESULTS
Both univariate and multivariate analysis disclosed a poor correlation between hyperleptinemia and markers of protein malnutrition. In fact, there were trends to a positive correlation between leptinemia and body protein stores, as estimated from the scrutinized markers. Persistence of the basic correlation between general intake, fat mass and leptin in CRF could partially explain these findings, but neither a negative correlation between leptin levels nor protein nutritional state could be disclosed after controlling for this factor.


CONCLUSIONS
Our results do not support a first-line role for hyperleptinemia in the genesis of protein malnutrition of uremia.
Rodríguez-Carmona
A
A
Nephrology, Hospital Juan Canalejo, Department of Medicine, University of La Coruña, Spain.
Pérez Fontán
M
M
Cordido
F
F
García Falcón
T
T
García-Buela
J
J
D000328:Adult; D000368:Aged; D015415:Biomarkers; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011228:Prealbumin / Q000378:metabolism; D011502:Protein-Energy Malnutrition / Q000097:blood* / Q000209:etiology; D006435:Renal Dialysis; D012709:Serum Albumin; D014168:Transferrin / Q000378:metabolism; D014511:Uremia / Q000097:blood / Q000150:complications / Q000628:therapy
D015415:Biomarkers; D020738:Leptin; D011228:Prealbumin; D012709:Serum Albumin; D014168:Transferrin; D007334:Insulin-Like Growth Factor I