title: Morphological variability of the trabecular meshwork in glaucoma patients: implications for non-perforating glaucoma surgery.
abstract: OBJECTIVE
  Morphological variability of the trabecular meshwork could be of considerable importance for the proper intraoperative outcome of non-perforating antiglaucomatous surgery, such as deep sclerectomy and viscocanalostomy. The aim of this study was therefore to assess qualitative and quantitative characteristics of the trabecular meshwork in glaucoma patients undergoing trabeculectomy.
  
  
  METHODS
  Trabeculectomy specimens from 177 glaucoma patients were prepared for light microscopy; 100 specimens were found to be suitable for qualitative assessment and quantitative computerised image analysis; measurements were taken of the meridional diameter of Schlemm's canal as well as the thickness of the trabecular meshwork at different positions.
  
  
  RESULTS
  The mean meridional diameter of Schlemm's canal was 290 microm with the smallest values in the young patients with infantile and secondary glaucomas. the thickness of the trabecular meshwork ranged between 50-70 microm in the anterior region and between 100-130 microm for the posterior portion. The thickness of the anterior meshwork significantly decreased with age. The pigmentation of excised trabecular meshwork was found to be weak or even lacking in 68 patients. In 20 glaucoma patients the uveal meshwork was covered by an endothelial layer.
  
  
  CONCLUSIONS
  From the morphological point of view the risk of inadvertent perforation during deep sclerectomy in older, white glaucoma patients should be taken into account even by an experienced surgeon, because the anterior meshwork in these cases is very thin and trabecular pigmentation that can be used as a topographic landmark is often lacking. The functional success of non-perforating glaucoma surgery in many patients may be limited by endothelial covering of the trabecular meshwork.
authors.affiliation: Department of Ophthalmology, University of Cologne, Germany. aia47@uni-koeln.de
authors.forename: T S
authors.initials: TS
authors.lastname: Dietlein
authors.forename: P C
authors.initials: PC
authors.lastname: Jacobi
authors.forename: C
authors.initials: C
authors.lastname: Lüke
authors.forename: G K
authors.initials: GK
authors.lastname: Krieglstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005901:Glaucoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007223:Infant; D016014:Linear Models; D008875:Middle Aged; D014129:Trabecular Meshwork / Q000473:pathology*; D014130:Trabeculectomy / Q000379:methods*