Studies on the preparation and stability of samarium-153 propylene diamine tetramethylene phosphonate (PDTMP) complex as a bone seeker.
Propylene diamine tetra methylene phosphonate (PDTMP) was synthesised by modifying a method reported for the synthesis of EDTMP. Complexation of the synthesised phosphonate ligand with 153Sm was carried out by varying the experimental parameters and the complex was radiochemically characterized. Biodistribution studies showed that the uptake by bone in rats was 2% per g of bone, which was retained upto 48 h. The uptake by other organs was insignificant, except by the liver which showed a slightly higher absorption.
Majali
M A
MA
Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India. mythili@magnum.barc.ernet.in
Mathakar
A R
AR
Shimpi
H H
HH
Banerjee
S
S
Samuel
G
G
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004164:Diphosphonates / Q000737:chemistry / Q000302:isolation & purification*; D004355:Drug Stability; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D009942:Organometallic Compounds / Q000737:chemistry / Q000302:isolation & purification*; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000302:isolation & purification*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000302:isolation & purification*; D051381:Rats; D017208:Rats, Wistar; D012493:Samarium / Q000737:chemistry / Q000302:isolation & purification*; D014018:Tissue Distribution
D004164:Diphosphonates; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D019275:Radiopharmaceuticals; C417557:propylenediaminetetramethylene phosphonate; D012493:Samarium