title: Malignant lymphoma in nasal cavity and paranasal sinuses of a dog.
abstract: A case of a canine large cell type T-cell lymphoma, with features of high-grade malignancy is described. The tumour was found confined in the nasal cavity and the paranasal sinuses of a crossbred German Shepherd dog. Histological examination revealed the features of a highly malignant large cell lymphoma. Ultrastructurally, the lymphoid tumour cells bore cytoplasmic protrusions that interdigitated tightly. From a panel of tumour markers used, the neoplastic cells were stained only for vimentin. Immunophenotyping of the tumour cells by means of CD3, CD79, kappa-light chains and lambda-light chains detection was undertaken. The tumour stained only for CD3 and was classified as T-cell lymphoma.
authors.affiliation: Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Kaldrymidou
authors.forename: N
authors.initials: N
authors.lastname: Papaioannou
authors.forename: T
authors.initials: T
authors.lastname: Poutahidis
authors.forename: M
authors.initials: M
authors.lastname: Karayannopoulou
authors.forename: E
authors.initials: E
authors.lastname: Gruys
authors.forename: T
authors.initials: T
authors.lastname: Toliou
authors.forename: T
authors.initials: T
authors.lastname: Tsangaris
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology / Q000662:veterinary*; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000662:veterinary; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography
chemical_list: D000911:Antibodies, Monoclonal