title: Combined semantic dementia and apraxia in a patient with frontotemporal lobar degeneration.
abstract: In this study we report neuropsychological and brain-imaging findings in a patient with frontotemporal lobar degeneration. Brain imaging using registration of (18)fluorodeoxyglucose (FDG)-PET data to three-dimensional (3-D) magnetic resonance imaging showed atrophy and highly significant hypometabolism of the left temporal lobe and both frontal lobes. Volumetric measurements of the hippocampi/amygdala showed a reduction in volume of 25% on the left compared to right within cortical areas. Neuropsychological testing revealed semantic dementia with severe anomia as well as apraxia with impairment of both recognition and production of motor acts. The implications of this case of early manifestation of frontotemporal lobar degeneration for our knowledge of dementia are discussed.
authors.affiliation: Department of Psychiatry, University of Freiburg, Freiburg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Schumann
authors.forename: U
authors.initials: U
authors.lastname: Halsband
authors.forename: J
authors.initials: J
authors.lastname: Kassubek
authors.forename: S
authors.initials: S
authors.lastname: Gustin
authors.forename: T
authors.initials: T
authors.lastname: Heinks
authors.forename: F D
authors.initials: FD
authors.lastname: Juengling
authors.forename: M
authors.initials: M
authors.lastname: Hüll
mesh_terms: D000849:Anomia / Q000209:etiology; D001072:Apraxias / Q000209:etiology; D001284:Atrophy; D003704:Dementia / Q000209:etiology / Q000473:pathology / Q000523:psychology*; D003937:Diagnosis, Differential; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D020774:Pick Disease of the Brain / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000523:psychology*; D012660:Semantics; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology*; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18