The synthesis of novel 6,5- and 6,6-membered fused heterocyclic compounds derived from thymine.
Novel pyrimido[1,2-a]pyrimidinones 14, 15 and 16 and imidazo[1,2-a] pyrimidinones 19 and 20, designed as conformationally constrained analogues of 1-(3-amino-2-hydroxypropyl)thymine and 1-(2-amino-3-hydroxypropyl)thymine, respective ly, were synthesized by the ring-opening/ ring-closure rearrangement of the corresponding byciclic oxygen-containing amino compounds 12 and 17.
Jokić
M
M
Ruder Bosković Institute, Department of Organic Chemistry and Biochemistry, Zagreb, Croatia.
Raza
Z
Z
Katalenić
D
D
D015195:Drug Design; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D011741:Pyrimidine Nucleosides / Q000737:chemistry*; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry*; D013941:Thymine / Q000737:chemistry*
D011725:Pyridines; D011741:Pyrimidine Nucleosides; D011744:Pyrimidinones; C001439:imidazo(1,2-a)pyridine; D013941:Thymine