title: Screening search for organic fluorophores: syntheses and fluorescence properties of 3-azolyl-7-diethylaminocoumarin derivatives.
abstract: In order to find a highly sensitive fluorophore, 3-azolyl-7-diethylaminocoumarin derivatives were synthesized. Both the absorption and fluorescence maxima of the coumarin-thiazole compounds showed red shifts with increases of the molar absorptivities and fluorescence intensities, in comparison with those of the corresponding coumarin-oxazole compounds. Among them, 3-(5-ethoxycarbonyl-1,3-thiazol-2-yl)-7-diethylamino-2H-chromen -2-one (3e) was one of the most promising candidates as a fluorophore accessible for analytical purposes in the fields of analytical and biological chemistry.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takechi
authors.forename: Y
authors.initials: Y
authors.lastname: Oda
authors.forename: N
authors.initials: N
authors.lastname: Nishizono
authors.forename: K
authors.initials: K
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Machida
mesh_terms: D001393:Azoles / Q000138:chemical synthesis*; D003374:Coumarins / Q000138:chemical synthesis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D013058:Mass Spectrometry; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared
chemical_list: D001393:Azoles; D003374:Coumarins; D005456:Fluorescent Dyes