title: Postoperative analgesia in the cat after ovariohysterectomy by use of carprofen, ketoprofen, meloxicam or tolfenamic acid.
abstract: The adequacy of postoperative analgesia was assessed in 40 cats following ovariohysterectomy. At extubation, cats were given one dose of carprofen, ketoprofen, meloxicam or tolfenamic acid. Postoperative analgesia was assessed using visual analogue scale (VAS) scoring for pain and sedation; measurement of mechanical nociceptive thresholds at the wound; recognition of the requirement for rescue intervention analgesia; and an overall clinical assessment score at 18 hours. VAS pain scores were low throughout the trial, with no significant differences found between the groups. Postoperative mechanical nociceptive thresholds decreased significantly from baseline in all four groups, with no significant differences between the groups. One cat in each of the tolfenamic acid, ketoprofen and meloxicam groups required rescue intervention analgesia. Nine out of 10 cats in all four groups were classified as having desirable overall clinical assessment scores. In summary, all four drugs provided good postoperative analgesia, although none was able to prevent postoperative wound tenderness.
authors.affiliation: Department of Clinical Veterinary Science, University of Bristol, Langford.
authors.forename: L S
authors.initials: LS
authors.lastname: Slingsby
authors.forename: A E
authors.initials: AE
authors.lastname: Waterman-Pearson
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use; D002415:Cats / Q000601:surgery*; D005260:Female; D007044:Hysterectomy / Q000662:veterinary*; D007660:Ketoprofen / Q000627:therapeutic use; D000077239:Meloxicam; D010052:Ovariectomy / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000188:drug therapy / Q000662:veterinary*; D013843:Thiazines / Q000627:therapeutic use; D013844:Thiazoles / Q000627:therapeutic use; D016896:Treatment Outcome; D062367:ortho-Aminobenzoates / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D013843:Thiazines; D013844:Thiazoles; D062367:ortho-Aminobenzoates; C009500:tolfenamic acid; D007660:Ketoprofen; C007005:carprofen; D000077239:Meloxicam