Oxidants, oxidative stress and the biology of ageing.
Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.
Finkel
T
T
Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute/National Institutes of Health, Bethesda, Maryland 20892-1622, USA. finkelt@nih.gov
Holbrook
N J
NJ
D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence / Q000502:physiology; D002149:Energy Intake; D006801:Humans; D008136:Longevity; D016877:Oxidants / Q000502:physiology*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D015398:Signal Transduction
D016877:Oxidants; D017382:Reactive Oxygen Species