title: Frequency, risk factors, and clinical outcomes of left ventricular assist device-associated ventricular thrombus.
abstract: A retrospective, transesophageal study of 51 consecutive patients receiving a left ventricular (LV) assist device (AD) over a 2-year period showed that LVAD-associated LV thrombosis (16%) was predicted by acute myocardial infarction, atrial cannulation, and postimplantation bleeding, and was associated with a fourfold increased risk of stroke compared with patients without thrombosis. LV cannulation, when using short-term LVADs, may decrease the incidence of LV thrombosis, and early transition to Heartmate-LVAD support may improve outcome.
authors.affiliation: Department of Medicine, University of Pennsylvania Health System, Philadelphia 19014, USA. muredach@spirit.gcrc.upenn.edu.
authors.forename: M P
authors.initials: MP
authors.lastname: Reilly
authors.forename: S E
authors.initials: SE
authors.lastname: Wiegers
authors.forename: A J
authors.initials: AJ
authors.lastname: Cucchiara
authors.forename: M L
authors.initials: ML
authors.lastname: O'Hara
authors.forename: T J
authors.initials: TJ
authors.lastname: Plappert
authors.forename: E
authors.initials: E
authors.lastname: Loh
authors.forename: M A
authors.initials: MA
authors.lastname: Acker
authors.forename: M
authors.initials: M
authors.lastname: St John Sutton
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D003327:Coronary Disease / Q000150:complications / Q000628:therapy; D017548:Echocardiography, Transesophageal; D004868:Equipment Failure; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D006352:Heart Ventricles; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D016896:Treatment Outcome