Prediction of diabetes in Biobreeding/Aburahi rats by the measurement of soluble L-selectin.
L-selectin was initially identified as a homing receptor, recently soluble L-selectin has been used as a marker of the inflammation. Therefore, we investigated the relation between the development of diabetes and serum L-selectin levels in the Biobreeding (BB) rats. Serum L-selectin were measured from 30 days old to the onset of diabetes or to 90 days old in Biobreeding (BB) rats and Wistar Furth (WF) rats. Significant elevation of L-selectin was found in diabetes prone (DP) rats from 45 days old to the onset of diabetes or through 90 days old. No elevation was found in other strain of rats. In histological study, all of DP rats had insulitis and no other strain of rats had it. Therefore, we conclude that the measurement of serum L-selectin could be useful tool to predict the onset of diabetes or presence of insulitis in BB rats.
Tanaka
T
T
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Nakamur
N
N
Kitagawa
Y
Y
Shigeta
H
H
Hasegawa
G
G
Obayashi
H
H
Miyasaka
M
M
Nakao
H
H
Makino
S
S
Kondo
M
M
D000367:Age Factors; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000175:diagnosis* / Q000276:immunology; D019041:L-Selectin / Q000097:blood*; D051381:Rats; D011913:Rats, Inbred BB; D011920:Rats, Inbred WF; D012995:Solubility
D019041:L-Selectin