[Intraperitoneal administration of CPT-11 in rats--experimental study for pharmacokinetics].
The pharmacokinetics of CPT-11 administered into rats to evaluate the future possibility of i.p. administration was investigated. Serum, bile juice, and intraperitoneal fluid was collected to measure the concentration of CPT-11, its metabolite SN-38, and SN-38 glucuronized (SN-38 glu). The concentration of CPT-11 was elevated after CPT-11 administration into the peritoneal cavity. The serum and biliary concentrations of SN-38 and SN-38 glu were increased and prolonged shortly after i.p. administration of CPT-11. These results suggest the possibility of i.p. administration of CPT-11 in the future.
Nagahama
T
T
Dept. of Surgery Tokyo Metropolitan Ohkubo Hospital.
Maruyama
M
M
Goseki
N
N
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics*; D001646:Bile / Q000378:metabolism; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D000077146:Irinotecan; D010537:Peritoneum / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002166:Camptothecin