Short wavelength light-induced retinal damage in rats.
OBJECTIVE
To evaluate short wavelength light-induced retinal damage in rats.


METHODS
Pigmented rats were exposed to 300-500 nm wavelength light for 30 seconds, 1, 3, 10, 20, 60, or 90 minutes. Electroretinogram a-, b-, and c-waves were recorded 48 hours after the exposure.


RESULTS
While the a- and b-wave amplitudes were reduced significantly after exposures of 60 minutes and longer, the c-wave amplitude was reduced after only 3 minutes of exposure.


CONCLUSIONS
Rat retinal pigment epithelium is more sensitive to damage by exposure to 300-500 nm wavelength light than the neural retina.
Masuda
K
K
Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Watanabe
I
I
D000818:Animals; D004596:Electroretinography; D008027:Light / Q000009:adverse effects*; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D012160:Retina / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects*; D012162:Retinal Degeneration / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors