title: [Frequency of dominant lethal mutations induced by combined exposure to incorporated 137Cs and external gamma-irradiation in mice].
abstract: The genetic effect of combined exposure to incorporated 137Cs and external gamma-irradiation was studied in germ cells of male mice. The activity of incorporated 137Cs was 3.7 x 10(4) Bq/g. The dose of external gamma-irradiation was 1.5 Gy. In the case of combined exposure, mice were treated with a cesium solution immediately after irradiation. The genetic effect was estimated by the frequency of dominant lethal mutations (DLM) induced at different stages of spermatogenesis. Upon combined exposure to external and internal irradiation, the frequency of DLM in premeiotic cells significantly exceeded the total frequency of DLM induced by separate exposure to external and internal irradiation; i.e., a marked synergistic interaction of external and internal irradiation was observed.
authors.affiliation: Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: M D
authors.initials: MD
authors.lastname: Pomerantseva
authors.forename: L K
authors.initials: LK
authors.lastname: Ramaia
authors.forename: A M
authors.initials: AM
authors.lastname: Liaginskaia
mesh_terms: D000818:Animals; D001610:Beta Particles; D002588:Cesium Radioisotopes; D005260:Female; D005720:Gamma Rays; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests; D018812:Paternal Exposure; D011839:Radiation, Ionizing; D012098:Reproduction / Q000528:radiation effects; D013091:Spermatogenesis / Q000528:radiation effects
chemical_list: D002588:Cesium Radioisotopes