Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage.
OBJECTIVE
To evaluate the relationship between ocular perfusion pressure and color Doppler measurements in patients with glaucoma.


METHODS
Twenty patients with primary open-angle glaucoma with visual field deterioration in spite of an intraocular pressure lowered below 21 mm Hg, 20 age-matched patients with glaucoma with stable visual fields, and 20 age-matched healthy controls were recruited. After a 20-minute rest in a supine position, intraocular pressure and color Doppler measurements parameters of the ophthalmic artery and the central retinal artery were obtained. Correlations between mean ocular perfusion pressure and color Doppler measurements parameters were determined.


RESULTS
Patients with glaucoma showed a higher intraocular pressure (P <.0008) and a lower mean ocular perfusion pressure (P <.0045) compared with healthy subjects. Patients with deteriorating glaucoma showed a lower mean blood pressure (P =.033) and a lower end diastolic velocity in the central retinal artery (P =.0093) compared with normals. Mean ocular perfusion pressure correlated positively with end diastolic velocity in the ophthalmic artery (R = 0.66, P =.002) and central retinal artery (R = 0.74, P <.0001) and negatively with resistivity index in the ophthalmic artery (R = -0.70, P =.001) and central retinal artery (R = -0.62, P =.003) in patients with deteriorating glaucoma. Such correlations did not occur in patients with glaucoma with stable visual fields or in normal subjects. The correlations were statistically significantly different between the study groups (parallelism of regression lines in an analysis of covariance model) for end diastolic velocity (P =.001) and resistivity index (P =.0001) in the ophthalmic artery, as well as for end diastolic velocity (P =.0009) and resistivity index (P =. 001) in the central retinal artery.


CONCLUSIONS
The present findings suggest that alterations in ocular blood flow regulation may contribute to the progression in glaucomatous damage.
Gherghel
D
D
University Eye Clinic, Basel, Switzerland.
Orgül
S
S
Gugleta
K
K
Gekkieva
M
M
Flammer
J
J
D000368:Aged; D001783:Blood Flow Velocity; D001794:Blood Pressure; D005123:Eye / Q000098:blood supply*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009880:Ophthalmic Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010477:Perfusion; D011312:Pressure; D012161:Retinal Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018615:Ultrasonography, Doppler, Color; D014794:Visual Fields