Formation of 9,10-unsaturation in the mitomycins: facile fragmentation of beta-alkyl-beta-aryl-alpha-oxo-gamma-butyrolactones.
A facile fragmentation of beta-alkyl-beta-aryl-alpha-oxo-gamma-butyrolactones is reported. A study to assist in the elucidation of the mechanism of the reaction is also revealed.
Ziegler
F E
FE
Sterling Chemistry Laboratory, Yale University, New Haven, Connecticut 06511-8118, USA. frederick.ziegler@yale.edu
Berlin
M Y
MY
Lee
K
K
Looker
A R
AR
D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D002087:Butyrates / Q000737:chemistry*; D007202:Indicators and Reagents; D007783:Lactones / Q000737:chemistry*; D008937:Mitomycins / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000903:Antibiotics, Antineoplastic; D002087:Butyrates; D007202:Indicators and Reagents; D007783:Lactones; D008937:Mitomycins