Animal models to assess the effects of air pollutants on allergic lung disease.
Animal models provide toxicologists with useful tools for assessing risks associated with respiratory allergy. Both the mouse and BN rat models described exhibit many of the features of human allergic asthma. It is clear that environmental contaminants can exacerbate the expression of these features. Work is under way to explore underlying mechanisms and to develop methods for applying these data to human health risk assessment.
Selgrade
M K
MK
National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA. Selgrade.MaryJane@EPA.Gov
Lambert
A L
AL
Ward
M D
MD
Gilmour
M I
MI
D000393:Air Pollutants / Q000276:immunology / Q000633:toxicity*; D000485:Allergens / Q000276:immunology*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology; D002244:Carbon / Q000276:immunology / Q000633:toxicity; D060729:Coal Ash; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D005658:Fungi / Q000276:immunology; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008925:Mites / Q000276:immunology; D052638:Particulate Matter; D051381:Rats
D000393:Air Pollutants; D000485:Allergens; D060729:Coal Ash; D016207:Cytokines; D052638:Particulate Matter; D007073:Immunoglobulin E; D002244:Carbon