An approach to multi-copy search in molecular replacement.
The molecular-replacement method has been extended to a simultaneous search for multiple copies of the macromolecule in the unit cell. The central point of this approach is the construction of a multi-copy search model from the properly oriented monomers using a special translation function. The multi-copy search method has been implemented in the program MOLREP and successfully tested using experimental data.
Vagin
A
A
Department of Chemistry, University of York, Heslington, York YO1 5DD, England. alexei@ysbl.york.ac.uk
Teplyakov
A
A
D000465:Algorithms; D002135:Calcium-Binding Proteins / Q000737:chemistry; D003461:Crystallography / Q000379:methods*; D018360:Crystallography, X-Ray; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry; D008962:Models, Theoretical; D009414:Nerve Growth Factors / Q000737:chemistry; D011487:Protein Conformation; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D012984:Software
D002135:Calcium-Binding Proteins; D007140:Immunoglobulin Fab Fragments; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins