title: Melatonin secretion after surgery.
abstract: Sleep disturbance is common postoperatively. We examined whether melatonin concentrations were related to this disturbance in seven postoperative patients. Nocturnal concentrations of melatonin were significantly (p=0.005) lower on the first than on the second or third nights after surgery. This finding raises the possibility that melatonin suppression and associated sleep disturbance might be prevented by melatonin replacement.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cronin
authors.forename: J C
authors.initials: JC
authors.lastname: Keifer
authors.forename: M F
authors.initials: MF
authors.lastname: Davies
authors.forename: T S
authors.initials: TS
authors.lastname: King
authors.forename: E O
authors.initials: EO
authors.lastname: Bixler
mesh_terms: D000328:Adult; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology; D012893:Sleep Wake Disorders / Q000097:blood / Q000209:etiology
chemical_list: D008550:Melatonin