Unusual corneal deposit after the topical use of cyclosporine as eyedrops.
OBJECTIVE
To report a patient who developed bilateral corneal opacities 5 days after the beginning topical cyclosporine.


METHODS
Case report. A 45-year-old woman with graft-versus-host disease presented with bilateral corneal deposits. She had been treated with topical physiological saline solution, sodium hyaluronate, ofloxacin, fluorometholone, and oxybuprocaine. Cyclosporine eyedrops were added for persistent corneal epithelial defect bilaterally. Five days after cyclosporine, she complained of visual loss and dense corneal opacities were detected that covered the pupil bilaterally.


RESULTS
Deposits were also observed on the punctal plugs, and infrared spectroscopy and X-ray analysis showed that these deposits had properties of cyclosporine.


CONCLUSIONS
Topical cyclosporine, alone or in combination with other eyedrops, may cause severe corneal deposits in patients with disturbance of the corneal epithelial barrier and decreased tear clearance.
Kachi
S
S
Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan. kachishu-ngy@umin.ac.jp
Hirano
K
K
Takesue
Y
Y
Miura
M
M
D003315:Cornea / Q000187:drug effects*; D003318:Corneal Opacity / Q000139:chemically induced*; D016572:Cyclosporine / Q000009:adverse effects* / Q000737:chemistry; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000737:chemistry; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000009:adverse effects / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D013055:Spectrophotometry, Infrared
D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions; D016572:Cyclosporine