title: Comparison of postoperative acute-phase reactants in patients who underwent laparoscopic v open cholecystectomy: a randomized study.
abstract: OBJECTIVE
  We investigated the effect of laparoscopic v open cholecystectomy on acute-phase reactants.
  
  
  METHODS
  Fifty patients were randomized to laparoscopic (Group 1) and 50 to open (Group 2) cholecystectomy. Preoperative and postoperative values for acute-phase reactants (ceruloplasmin, fibrinogen, Westergren sedimentation rate, alpha-1-antitrypsin, haptoglobin, and C-reactive protein) in blood samples were compared.
  
  
  RESULTS
  Acute-phase reactants and length of hospitalization were significantly lower in patients who underwent a laparoscopic cholecystectomy than in those who underwent an open cholecystectomy.
  
  
  CONCLUSIONS
  Laparoscopic cholecystectomy appears associated with a less intense stress response and less tissue damage than open cholecystectomy.
authors.affiliation: Department of Surgery, Ankara University Medical School, Ibn-i Sina Hospital, Turkey. sdemirer@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Demirer
authors.forename: K
authors.initials: K
authors.lastname: Karadayi
authors.forename: S
authors.initials: S
authors.lastname: Simşek
authors.forename: N
authors.initials: N
authors.lastname: Erverdi
authors.forename: C
authors.initials: C
authors.lastname: Bumin
mesh_terms: D000210:Acute-Phase Reaction / Q000209:etiology*; D000328:Adult; D000368:Aged; D002763:Cholecystectomy / Q000009:adverse effects / Q000379:methods; D017081:Cholecystectomy, Laparoscopic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged