title: NMR analysis of tautomerisms of active pinacidil-type potassium channel openers and a less active one.
abstract: In order to clarify the structural difference between active pinacidil-type potassium channel openers and a less active one, the tautomerisms of pinacidil derivatives 1-3 were investigated by NMR spectrometries. The predominant tautomer of the less active compound 3 was different from those of the active compounds 1 and 2.
authors.affiliation: Chemistry, Group, R&D Laboratories, Nippon Organon K.K., Osaka, Japan. yoshiizumi.kazuya@organon.co.jp
authors.forename: K
authors.initials: K
authors.lastname: Yoshiizumi
authors.forename: F
authors.initials: F
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Kiyoi
authors.forename: H
authors.initials: H
authors.lastname: Kondo
mesh_terms: D000959:Antihypertensive Agents / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020110:Pinacidil / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism*
chemical_list: D000959:Antihypertensive Agents; D015221:Potassium Channels; D020110:Pinacidil