title: Time to reconstitution: purified Fab antivenom vs. unpurified IgG antivenom.
abstract: We conducted prospective, randomized analytical and observational trials to assess reconstitution times of two lyophilized crotaline snake antivenoms, Antivenin (Crotalidae) Polyvalent [Wyeth-Ayerst] (ACP) and affinity-purified, mixed monospecific crotalid antivenom ovine Fab (CroTAb) (Fab antivenom). The analytical experiment indicated Fab antivenom and ACP reached their maximum protein concentration at 25 and 45min, respectively. In the observational experiment, Fab antivenom (median 40min) had a shorter reconstitution time than ACP (>90min, p<0.008).
authors.affiliation: Rocky Mountain Poison and Drug Center, Denver Health Authority, 1010 Yosemite Cir., 80230-6800, Denver, CO, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Hill
authors.forename: G M
authors.initials: GM
authors.lastname: Bogdan
authors.forename: R C
authors.initials: RC
authors.lastname: Dart
mesh_terms: D000997:Antivenins; D012103:Batroxobin; D003435:Crotalid Venoms; D004339:Drug Compounding; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D000997:Antivenins; D003435:Crotalid Venoms; D012103:Batroxobin