Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer.
Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity.
Kitajima
H
H
Department of Discovery Research, Welfide Corporation, Osaka, Japan. kitajima_hiroshi@welfide.co.jp
Nakamura
M
M
Tamakawa
H
H
Goto
N
N
D000818:Animals; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D051379:Mice; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013386:Succinates / Q000138:chemical synthesis* / Q000737:chemistry; D014280:Triglycerides / Q000378:metabolism
D001597:Benzylidene Compounds; D007004:Hypoglycemic Agents; D007328:Insulin; D013386:Succinates; D014280:Triglycerides