title: [New approaches to the treatment of patients with idiopathic mitral valve prolapse].
abstract: OBJECTIVE
  To assess efficiency of magnerot, magnesium orotate, in patients with idiopathic mitral prolapse (IMP).
  
  
  METHODS
  84 patients with IMP were randomized to the study group (43 patients) and control group (41 patients). Patients of the study group received magnerot tablets (Germany) containing 500 mg of magnesium orotate (daily dose 3000 mg) for 6 months. The examination performed before the treatment and 6 months after it included: modified clinical and phenotypic records, echocardiography, 24-h ECG and AP monitoring, spectral analysis of cardiac rhythm variability, evaluation of quality of life according to Visual Analog Scale and Disability Scale and of treatment results according to Clinical Global Impression scales, measurements of magnesium in the hair by plasmic nuclear emission spectrometry, histological and histochemical skin tests.
  
  
  RESULTS
  IMP patients appeared to suffer from magnesium deficiency which is responsible for many symptoms in mitral prolapse. 6-month therapy with magnerot completely or partially reduced the symptoms in more than half the patients. Positive changes were registered primarily in clinicofunctional manifestations. Morphological changes in the skin correlating with the disease severity alleviated.
  
  
  CONCLUSIONS
  Good objective and subjective response to magnerot 6-month therapy (3000 mg/day) is demonstrated.
authors.forename: A I
authors.initials: AI
authors.lastname: Martynov
authors.forename: O B
authors.initials: OB
authors.lastname: Stepura
authors.forename: A B
authors.initials: AB
authors.lastname: Shekhter
authors.forename: O O
authors.initials: OO
authors.lastname: Mel'nik
authors.forename: L S
authors.initials: LS
authors.lastname: Pak
authors.forename: T I
authors.initials: TI
authors.lastname: Ushakova
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003627:Data Interpretation, Statistical; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008275:Magnesium Deficiency / Q000150:complications / Q000188:drug therapy; D008297:Male; D008945:Mitral Valve Prolapse / Q000175:diagnosis / Q000188:drug therapy*; D009963:Orotic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000924:Anticholesteremic Agents; D009963:Orotic Acid; C104468:magnesium orotate