title: Drug-induced stabilization of covalent DNA topoisomerase I-DNA intermediates. DNA cleavage assays.
authors.affiliation: Department of Pharmaceutical Science, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: P
authors.initials: P
authors.lastname: Fiorani
authors.forename: C L
authors.initials: CL
authors.lastname: Hann
authors.forename: P
authors.initials: P
authors.lastname: Benedetti
authors.forename: M A
authors.initials: MA
authors.lastname: Bjornsti
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives / Q000494:pharmacology*; D002478:Cells, Cultured; D004264:DNA Topoisomerases, Type I / Q000378:metabolism*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D004795:Enzyme Stability / Q000187:drug effects; D006801:Humans; D010957:Plasmids / Q000235:genetics / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D059004:Topoisomerase I Inhibitors
chemical_list: D000970:Antineoplastic Agents; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D059004:Topoisomerase I Inhibitors; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin