title: Successful treatment of protein-losing enteropathy due to AA amyloidosis with somatostatin analogue and high dose steroid in ankylosing spondylitis.
abstract: Secondary amyloidosis is an occasional complication of ankylosing spondylitis (AS) and in most cases renal amyloidosis presents with proteinuria, nephrotic syndrome and decreased renal function. We describe a 32-year-old male patient with AS manifested by frequent diarrhea, intermittent abdominal pain and low serum albumin levels. He has suffered from severe inflammatory back pain for 14 years with multiple peripheral joint involvement. Protein-losing enteropathy due to gastrointestinal amyloidosis was diagnosed with 99mTc-human albumin scintigraphy, fecal alpha-1 antitrypsin clearance and colonoscopic biopsy with Congo red staining. Somatostatin analogue octreotide and prednisolone were introduced with successful result.
authors.affiliation: Division of Rheumatology, Hospital for Rheumatic Diseases, Seoul, Korea.
authors.forename: Y S
authors.initials: YS
authors.lastname: Jeong
authors.forename: J B
authors.initials: JB
authors.lastname: Jun
authors.forename: T H
authors.initials: TH
authors.lastname: Kim
authors.forename: I H
authors.initials: IH
authors.lastname: Lee
authors.forename: S C
authors.initials: SC
authors.lastname: Bae
authors.forename: D H
authors.initials: DH
authors.lastname: Yoo
authors.forename: M H
authors.initials: MH
authors.lastname: Park
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use*; D011239:Prednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D011504:Protein-Losing Enteropathies / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D011877:Radionuclide Imaging; D013004:Somatostatin / Q000031:analogs & derivatives*; D013167:Spondylitis, Ankylosing / Q000150:complications*
chemical_list: D005765:Gastrointestinal Agents; D005938:Glucocorticoids; D013004:Somatostatin; D011239:Prednisolone; D015282:Octreotide