Total synthesis of (+)-7-deoxypancratistatin from furan.
A new total synthesis of (+)-7-deoxypancratistatin 1 has been accomplished in 19 steps (8% overall yield) from two readly available compounds, furan and trans-1,2-bis(phenylsulfonyl)ethylene.
Aceña
J L
JL
Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense, 28040 Madrid, Spain.
Arjona
O
O
León
M L
ML
Plumet
J
J
D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D005663:Furans / Q000737:chemistry*; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*
C418326:7-deoxypancratistatin; D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007202:Indicators and Reagents; D007546:Isoquinolines; C044997:pancratistatin