Assessment of a genetic contribution to osteoarthritis of the hip: sibling study.
OBJECTIVE
To study the influence of genetics on the development of hip osteoarthritis as determined by structural change on plain radiographs.


METHODS
Sibling study.


METHODS
Nottinghamshire, England.


METHODS
392 index participants with hip osteoarthritis of sufficient severity to warrant total hip replacement, 604 siblings of the index participants, and 1718 participants who had undergone intravenous urography.


METHODS
Odds ratios for hip osteoarthritis in siblings.


RESULTS
The age adjusted odds ratios in siblings were 4.9 (95% confidence interval, 3.9 to 6.4) for probable hip osteoarthritis and 6.4 (4.5 to 9.1) for definite hip osteoarthritis. These values were not significantly altered by adjusting for other risk factors.


CONCLUSIONS
Siblings have a high risk of hip osteoarthritis as shown by structural changes on plain radiographs. One explanation is that hip osteoarthritis is under strong genetic influence.
Lanyon
P
P
Clinical Immunology Unit, Queens Medical Centre, Nottingham NG7 2UH, UK.
Muir
K
K
Doherty
S
S
Doherty
M
M
D017677:Age Distribution; D000368:Aged; D015992:Body Mass Index; D004739:England / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016017:Odds Ratio; D015207:Osteoarthritis, Hip / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D015995:Prevalence; D012307:Risk Factors; D014567:Urography