[Effect of electrolytes on hydration of lyophilized xerogel] .
Using a hydrated filtering membrane, the rate of hydration of the lyophilized xerogel hydroxypropylmethyl cellulose (HPMC) 4000 with an isotonic solution of sodium chloride was examined. The presence of the electrolyte influences the kinetics of diffuse hydration linearized by the root of time. Sodium chloride or pilocarpinium chloride significantly accelerates hydration compared with the hydration of xerogel alone. The effect of atropinium sulphate and scopolaminium bromide is not significant. Significant correlation was demonstrated between the density of HPMC 4000 in xerogel and the rate of its hydration. This density can be influenced by the conditions of lyophilization or the kind and amount of the added active ingredient.
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Katedra farmaceutické technologie Farmaceutické fakulty, Univerzity Karlovy, Hradec Králové.
D004573:Electrolytes; D005612:Freeze Drying; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives*; D014783:Viscosity; D014867:Water
D004573:Electrolytes; D014867:Water; D065347:Hypromellose Derivatives; D008747:Methylcellulose