title: Human papillomavirus infection of non-melanoma skin cancers in immunocompetent hosts.
abstract: Human papilloma viruses (HPVs) consist of more than 70 different types and are known to be associated with numerous malignant tumors, including carcinomas of the mucosal and cutaneous epithelium. Non-melanoma skin carcinoma (NMSC) is the most frequently occurring malignancy worldwide in the Caucasian population. Most studies examining the involvement of papillomaviruses in the development of cutaneous carcinomas have been performed on lesions from patients with epidermodysplasia verruciformis or from immunosuppressed patients. Our specimens were obtained from 108 immunocompetent patients with benign and malignant skin lesions, and HPVs were detected in 27%. HPV 8 and HPV 18 were the most frequent types (62 and 48%, respectively). Our results suggest that HPVs, particularly the oncogenic potential of certain types such as HPV 8, 18, and 5 could contribute to the development of NMSCs.
authors.affiliation: Laboratory of Virology, Medical School, University of Crete, Heraklion 71409, Crete, Greece.
authors.forename: K A
authors.initials: KA
authors.lastname: Biliris
authors.forename: E
authors.initials: E
authors.lastname: Koumantakis
authors.forename: D N
authors.initials: DN
authors.lastname: Dokianakis
authors.forename: G
authors.initials: G
authors.lastname: Sourvinos
authors.forename: D A
authors.initials: DA
authors.lastname: Spandidos
mesh_terms: D002280:Basal Cell Carcinoma / Q000235:genetics / Q000276:immunology / Q000821:virology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000276:immunology / Q000821:virology*; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005914:Globins / Q000235:genetics; D006801:Humans; D007121:Immunocompetence; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000276:immunology / Q000821:virology*; D016133:Polymerase Chain Reaction / Q000379:methods; D011230:Precancerous Conditions / Q000235:genetics / Q000276:immunology / Q000821:virology; D012878:Skin Neoplasms / Q000235:genetics / Q000276:immunology / Q000821:virology*; D014412:Tumor Virus Infections / Q000276:immunology / Q000821:virology*
chemical_list: D004273:DNA, Neoplasm; D004279:DNA, Viral; D005914:Globins