The calcium-phosphate-induced fusion of human erythrocytes.
The calcium-phosphate-induced fusion of normal human erythrocytes with those having increased (above physiological) levels of intracellular ATP was studied. Fusion of erythrocytes was markedly enhanced in the case of increased content of intracellular ATP. Fusion of such erythrocytes results in formation of giant cells up to 130 microm in diameter. Dithiothreitol practically completely inhibited fusion of erythrocytes with normal ATP content and markedly lowered it between those with increased ATP content.
Sheremetyev YuA
State Agricultural Academy, Nizhny Novgorod, Russia.
Fomin
I L
IL
Suslov FYu
Sheremetyeva
A V
AV
Orlov
B N
BN
D002130:Calcium Phosphates / Q000494:pharmacology*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008561:Membrane Fusion / Q000187:drug effects*
D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous