title: Antibodies to endostatin in a multifocal glioblastoma patient.
abstract: Endostatin, a C-terminal fragment of collagen XVIII is involved in the regulation of neovascularisation in solid tumours in mice. However, few data are available on the concentration of endostatin protein in patients with cancer. Paradoxical results obtained in this way prompted us to investigate an antibody to endostatin. We detected antibodies to endostatin in the serum and in the tumour brain tissue of a patient with a multifocal glioblastoma, and in the serum samples from two patients with aggressive tumours. These data suggest that endostatin overexpression by tumour tissue might induce a humoral immune response.
authors.forename: D
authors.initials: D
authors.lastname: Ratel
authors.forename: V
authors.initials: V
authors.lastname: Nasser
authors.forename: I
authors.initials: I
authors.lastname: Dupré
authors.forename: A L
authors.initials: AL
authors.lastname: Benabid
authors.forename: F
authors.initials: F
authors.lastname: Berger
mesh_terms: D020533:Angiogenesis Inhibitors / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000276:immunology*; D016022:Case-Control Studies; D003094:Collagen / Q000276:immunology*; D043170:Collagen Type XVIII; D043169:Endostatins; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005909:Glioblastoma / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D051379:Mice; D010446:Peptide Fragments / Q000276:immunology*
chemical_list: D020533:Angiogenesis Inhibitors; D001323:Autoantibodies; D043170:Collagen Type XVIII; D043169:Endostatins; D010446:Peptide Fragments; D003094:Collagen