title: Capillary electrochromatography-electrospray ionization mass spectrometry for the qualitative investigation of the drug etodolac and its metabolites in biological samples.
abstract: On-line coupling of capillary electrochromatography (CEC) with electrospray ionization (ESI) mass spectrometry (MS) was used for the qualitative investigation of the biotransformation of the non-steroidal anti-inflammatory drug etodolac. The coupling of this electro-driven separation technique with mass spectrometry allowed us to demonstrate the presence of different metabolites of etodolac extracted from human urine.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Münster, Germany.
authors.forename: D B
authors.initials: DB
authors.lastname: Strickmann
authors.forename: G
authors.initials: G
authors.lastname: Blaschke
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000652:urine*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D017308:Etodolac / Q000652:urine*; D006801:Humans; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D017308:Etodolac