New insights on the pathogenesis of hypercalcemia in primary hyperparathyroidism.
The pathogenesis of hypercalcemia in primary hyperparathyroidism is attributed to increased calcium release from bone, increased calcium reabsorption in renal distal tubules, and increased intestinal calcium absorption. However, it remains unclear which factor is the main process. We encountered a 56-year-old woman with myasthenia gravis, in whom hypercalcemia and elevated serum parathyroid hormone (PTH) level were observed. Diagnosis of primary hyperparathyroidism was made. Treatment with methylprednisolone for myasthenia gravis was associated with a marked decrease in both biochemical markers of bone formation and resorption without any changes in endogenous cAMP and serum levels of calcium, PTH, and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. These findings suggest that the possible pathogenesis of hypercalcemia in primary hyperparathyroidism may be attributed to the increased calcium reabsorption in the kidney and the increased intestinal calcium absorption as a result of stimulated production of 1,25-(OH)2D3 in the kidney. It thus follows that the renal tubular effect rather than the skeletal effect of the PTH excess may play a pivotal role in the development of hypercalcemia in primary hyperparathyroidism.
Yonemura
K
K
Hemodialysis Unit, Hamamatsu University School of Medicine, Japan. katsuh@hama-med.ac.jp
Suzuki
H
H
Fujigaki
Y
Y
Hishida
A
A
D001862:Bone Resorption / Q000378:metabolism; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000097:blood / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000150:complications* / Q000209:etiology* / Q000378:metabolism; D006961:Hyperparathyroidism / Q000097:blood / Q000150:complications* / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D010281:Parathyroid Hormone / Q000097:blood
D010281:Parathyroid Hormone; D000242:Cyclic AMP; D002117:Calcitriol; D002118:Calcium; D008775:Methylprednisolone