title: Presence of apolipoprotein E epsilon4 allele in cerebral palsy.
abstract: The apolipoprotein E gene, which is located on chromosome 19, has three alleles (epsilon2, epsilon3, and epsilon4). Several recent publications associate the presence of the apolipoprotein E epsilon4 allele with the occurrence of neurologic diseases, and consider it a risk factor for the development of central nervous system affections. A group of 40 patients with cerebral palsy was studied and compared to a control group of 40 subjects, and higher occurrence of the allele epsilon4 in the group of subjects with cerebral palsy was observed. A significantly higher risk of developing cerebral palsy was demonstrated among those subjects with the apolipoprotein E epsilon4 allele.
authors.affiliation: Department of Orthopaedics, School of Medicine, University of São Paulo, Brazil. pebarros@netpoint.com.br
authors.lastname: Meirelles Kalil Pessoa de Barr
authors.forename: C J
authors.initials: CJ
authors.lastname: Rodrigues
authors.forename: T E
authors.initials: TE
authors.lastname: de Barros
authors.forename: R G
authors.initials: RG
authors.lastname: Bevilacqua
mesh_terms: D000483:Alleles; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D002547:Cerebral Palsy / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E