[Ultrastructural phenotypes of tumor cells of endocrine-cellular neoplasms of hepatopancreatoduodenal organs and their role in determining the degree of malignancy and prognosis of these diseases].
78 tumors of the hepatopancreoduodenal system were studied clinically, cytologically and ultrastructurally. Hormonal disturbances were observed in 36% of the patients. The 5-year survival after radical surgery did not depend on the tumor size, tumor cell atypia or metastases to the regional lymph nodes. The prognosis was worse when the tumor was located in the liver. Ultrastructural features of the tumor cells were reliable criteria of the malignancy degree and tumor prognosis. The prognosis, recurrence-free interval and survival improve with an increase in the number of ultrastructurally differentiated cells and organoids in cytoplasm, and with a reduction in nuclear polymorphism and number of dark cells. The degree of histologic and ultrastructural differentiation of tumor cells may not coincide.
Raĭkhlin
N T
NT
N. N. Blokhin Russian Cancer Research Centre, Moscow.
Smirnova
E A
EA
Badalian
Kh V
KhV
Chistiakova
O V
OV
Patiutko
Iu I
IuI
D000328:Adult; D000368:Aged; D001079:Apudoma / Q000401:mortality / Q000473:pathology* / Q000648:ultrastructure; D004379:Duodenal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000648:ultrastructure; D011379:Prognosis