[Relationship between parameters of hemostasis and manifestations of the metabolic syndrome in men with mild and moderate hypertension].
OBJECTIVE
To study the relationship between major hemostasis parameters and hypertriglyceridemia with or without insulin resistance/hyperinsulinemia in men suffering from mild or moderate arterial hypertension.


METHODS
Major hemostasis parameters including fibrinogen level, coagulation factor VII activity and fibrinolytic activity were analysed in groups of men with moderate or mild AH who had normal or elevated triglycerides level regarding presence or absence of insulin resistance/hyperinsulinemia.


RESULTS
High factor VII activity was found in both groups with insulin resistance irrespective of their triglycerides level. Patients with insulin resistance combined with hypertriglyceridemia had low fibrinolytic activity.


CONCLUSIONS
In men with metabolic syndrome components insulin resistance is accompanied with activation of coagulation external pathway, whereas combination of insulin resistance with hypertriglyceridemia was associated with hypofibrinolysis.
Ratnikova
L A
LA
Metel'skaia
V A
VA
Mamedov
M N
MN
Olfer'ev
A M
AM
Perova
N V
NV
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005167:Factor VII / Q000032:analysis; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D015228:Hypertriglyceridemia / Q000150:complications*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D012737:Sex Factors; D013577:Syndrome; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D005167:Factor VII; D002784:Cholesterol