Antiretroviral agents inhibit infection of human cells by porcine endogenous retroviruses.
The efficacy of antiretroviral drugs against porcine endogenous retroviruses (PERV) that may be harbored in pig organs intended for transplantation was examined in human cells in vitro. The nucleoside analogs zidovudine and dideoxyinosine were found to effectively inhibit PERV replication.
Powell
S K
SK
Genetic Therapy, Inc., a Novartis Company, Gaithersburg, Maryland 20878, USA.
Gates
M E
ME
Langford
G
G
Gu
M L
ML
Lockey
C
C
Long
Z
Z
Otto
E
E
D000595:Amino Acid Sequence; D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D002478:Cells, Cultured / Q000821:virology; D016049:Didanosine / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D008969:Molecular Sequence Data; D012190:Retroviridae / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D013553:Swine Diseases / Q000821:virology; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology*
D019380:Anti-HIV Agents; D015215:Zidovudine; D016049:Didanosine