Cardiovascular infection by Chlamydia pneumoniae is not related to apolipoprotein E genotype.
Chlamydia pneumoniae is detectable in the blood vessels of patients suffering from arteriosclerosis. Risk for arteriosclerosis is modulated by the apolipoprotein E (apoE) allele. We assessed the significance of the apoE genotype as a risk factor for vascular C. pneumoniae infection by determining the genotype of 30 coronary heart disease patients with PCR-proven C. pneumoniae infection of coronary artery tissue. The apoE genotype is not distinctly associated with an increased risk for vascular C. pneumoniae infection.
Gieffers
J
J
Institute of Medical Microbiology and Hygiene, Medical University of Lübeck, D-23538 Lübeck, Germany. gieffers@hygiene.mu-luebeck.de
Solbach
W
W
Maass
M
M
D001057:Apolipoproteins E / Q000235:genetics*; D023521:Chlamydophila Infections / Q000382:microbiology*; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D003327:Coronary Disease / Q000235:genetics / Q000382:microbiology*; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D012307:Risk Factors
D001057:Apolipoproteins E