Lymphomatoid granulomatosis in a 4-year-old boy.
Lymphomatoid granulomatosis is a necrotizing angiocentric and angiodestructive infiltrative process involving primarily the lung, skin, central nervous system, and kidney. The incidence is highest in middle-aged men and is rare in children. We report a case of lymphomatoid granulomatosis involving both skin and lung in a 4-year-old boy. The disease progressed to peripheral T-cell lymphoma, which was unusual in light of recent evidence suggesting a B-cell origin in the majority of cases.
LeSueur
B W
BW
Section of Dermatology, University of Arizona College of Medicine, Tucson, USA.
Ellsworth
L
L
Bangert
J L
JL
Hansen
R C
RC
D001706:Biopsy; D002471:Cell Transformation, Neoplastic; D002675:Child, Preschool; D003937:Diagnosis, Differential; D018450:Disease Progression; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D008171:Lung Diseases / Q000150:complications / Q000175:diagnosis*; D016411:Lymphoma, T-Cell, Peripheral / Q000209:etiology*; D008230:Lymphomatoid Granulomatosis / Q000150:complications* / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D008297:Male; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000175:diagnosis*; D016896:Treatment Outcome