Nicotine-induced nystagmus: three-dimensional analysis and dependence on head position.
Two- and three-dimensional analyses of nicotine-induced eye movements were performed in 53 subjects to evaluate whether they were primarily of vestibular or ocular motor origin. Nicotine-induced nystagmus was detected in 27 subjects (51%); in 25 of these (93%) it was modulated by otolith input. Three-dimensional analysis of nicotine-induced nystagmus revealed that it violates Listing's law. Taken together, these findings suggest that nicotine induces an imbalance in the vestibulo-ocular reflex.
Pereira
C B
CB
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximillians-University, Munich, Germany.
Strupp
M
M
Eggert
T
T
Straube
A
A
Brandt
T
T
D000328:Adult; D005133:Eye Movements / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006257:Head / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000494:pharmacology*; D011187:Posture; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*
D009538:Nicotine