title: Asthmatic subjects symptomatically worse at work: prevalence and characterization among a general asthma clinic population.
abstract: OBJECTIVE
  To assess the prevalence of a historical occupational component to asthma in an adult asthma clinic and to compare characteristics of asthmatic subjects with and without work-attributed symptoms.
  
  
  METHODS
  A retrospective review of data obtained from a physician-administered questionnaire, answers to which were obtained at the initial patient visit of asthmatic subjects, and which included specific questions regarding the relationship of work to symptoms. Chart review data were used to supplement information on workplace exposures and investigations.
  
  
  METHODS
  A university-based secondary- and tertiary-referral asthma clinic.
  
  
  METHODS
  Seven hundred thirty-one adult asthmatic subjects who were referred for assessment and management of asthma.
  
  
  METHODS
  Statistical analyses of asthmatic subjects with and without work-attributed symptoms and a determination, from chart review, of the likelihood of causes for symptomatic worsening of asthma at work.
  
  
  RESULTS
  Sixty percent of the patients (435) had adult onset of asthma, among whom 310 patients (71%) were employed at the time of their visit. Fifty-one patients reported their asthma to be worse at work (ie, 16% of adult-onset working asthmatic subjects). Sixteen of these patients (31%) had likely or possible sensitizer-induced occupational asthma (OA), and 49% likely had aggravation of underlying asthma. The other 20% of patients had possible OA or aggravation of underlying asthma at work.
  
  
  CONCLUSIONS
  Adult-onset asthmatic subjects commonly report a worsening of asthma at work, more commonly on the basis of likely aggravation of underlying asthma than on the basis of likely or possible OA.
authors.affiliation: Gage Occupational and Environmental Health Unit, University of Toronto, Toronto, Ontario, Canada. susan.tarlo@utoronto.ca
authors.forename: S M
authors.initials: SM
authors.lastname: Tarlo
authors.forename: K
authors.initials: K
authors.lastname: Leung
authors.forename: I
authors.initials: I
authors.lastname: Broder
authors.forename: F
authors.initials: F
authors.lastname: Silverman
authors.forename: D L
authors.initials: DL
authors.lastname: Holness
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001249:Asthma / Q000453:epidemiology* / Q000503:physiopathology; D016009:Chi-Square Distribution; D018450:Disease Progression; D004651:Employment; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure; D009864:Ontario / Q000453:epidemiology; D011159:Population Surveillance; D015995:Prevalence; D012189:Retrospective Studies; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires