title: [The neuronal zootype].
abstract: We present an hypothesis, derived from the zootype concept of Slack, Holland and Graham. The main point of this hypothesis is to postulate that the primordial function of the zootype genes is to design an appropriate neuronal network in bilaterian animals, by controlling the genes involved in the specificity of the axon pathways. This would be the primary function of the zootype genes in development and their primitive function in evolution. The hypothesis is discussed in view of the current knowledge on the Hox genes, their evolution, their genomic organisation, their expression and their targets.
authors.affiliation: UMR 7622, CNRS, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Deutsch
authors.forename: H
authors.initials: H
authors.lastname: Le Guyader
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D002490:Central Nervous System / Q000196:embryology; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics / Q000648:ultrastructure; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D016678:Genome; D008322:Mammals / Q000033:anatomy & histology / Q000196:embryology / Q000235:genetics; D008959:Models, Neurological; D009024:Morphogenesis / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D009420:Nervous System / Q000196:embryology*; D013045:Species Specificity
chemical_list: D009419:Nerve Tissue Proteins