title: Cortical dysplasia with ossification.
abstract: We present the first case of cortical dysplasia with extensive intracerebral ossification. An eight-year-old epilepsy patient with a calcified lesion was successfully treated by surgical intervention. Pathological examination revealed a number of bizarre dysplastic cells in the whole lesion, which consisted of an epileptogenic cerebral cortex and a nonepileptogenic hamartomatous lesion with adipose tissue, vascular tissue, calcification, and ossification. The patient was diagnosed as having cortical dysplasia with ossification. Our findings support the notion that cortical dysplasia has a multipotentiality of cellular differentiation, including various hamartomatous tissues. We suggest that cortical dysplasia should be considered as a potential cause for epileptogenicity of a hamartomatous lesion even when magnetic resonance imaging (MRI) fails to disclose cortical dysplasia.
authors.affiliation: Tokyo Metropolitan Neurological Hospital, Departments of Neurosurgery, Neuroradiology, and Pathology, Fuchu, Tokyo, Japan. maehara.norg@tmd.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Maehara
authors.forename: N
authors.initials: N
authors.lastname: Arai
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: A
authors.initials: A
authors.lastname: Yagishita
authors.forename: M
authors.initials: M
authors.lastname: Oda
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis* / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D002648:Child; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis* / Q000473:pathology; D006222:Hamartoma / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008297:Male; D009999:Ossification, Heterotopic / Q000175:diagnosis* / Q000473:pathology