Cytoskeleton: functions for tubulin modifications at last.
New studies show that three types of evolutionarily conserved post translational tubulin modification, polyglutamylation, polyglycylation and detyrosination, play important roles in vivo. These modifications appear to act by modulating the binding of molecular motors to the external surface of microtubules.
Rosenbaum
J
J
Department of Biology, Yale University, 310 Kline Biology Tower, New Haven, Connecticut 06511-8112, USA. joel.rosenbaum@yale.edu
D000818:Animals; D008870:Microtubules / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D020409:Molecular Motor Proteins / Q000378:metabolism; D009154:Mutation; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D013768:Tetrahymena / Q000235:genetics / Q000378:metabolism; D014404:Tubulin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D020409:Molecular Motor Proteins; D014404:Tubulin