title: Synthesis of alpha-substituted beta-amino acids using pseudoephedrine as a chiral auxiliary.
abstract: [reaction: see text] beta-Amino acids are becoming increasingly attractive as intermediates in the synthesis of a variety of molecular structures. However, few methods are available for the synthesis of alpha-substituted beta-amino acids that are both readily scalable and highly stereoselective. Herein we report a new method for synthesizing alpha-substituted beta-amino acids that satisfies both of these requirements using enantiomerically pure pseudoephedrine as a chiral auxiliary.
authors.affiliation: Molecumetics Ltd., 2023 120th Avenue NE, Bellevue, Washington 98005-2199, USA.
authors.forename: G
authors.initials: G
authors.lastname: Nagula
authors.forename: V J
authors.initials: VJ
authors.lastname: Huber
authors.forename: C
authors.initials: C
authors.lastname: Lum
authors.forename: B A
authors.initials: BA
authors.lastname: Goodman
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D004809:Ephedrine; D007202:Indicators and Reagents; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D007202:Indicators and Reagents; D011506:Proteins; D004809:Ephedrine