title: MR spectroscopy study of dichloroacetate treatment after ischemic stroke.
abstract: In a double-blind, placebo-controlled study, we used 1H MR spectroscopy to assess the effect of a single infusion of sodium dichloroacetate on lesion lactate 1 to 5 days after ischemic stroke. Apparent trends toward a reduction in lactate/N-acetyl compound ratios were seen at the higher drug doses employed, and in patients treated in the first 2 days following infarction. Use of spectroscopic measures as endpoints is feasible in acute stroke clinical trials.
authors.affiliation: University of New Mexico and the Albuquerque Veterans Administration Medical Center, 87108, USA. graham@unm.edu
authors.forename: G D
authors.initials: GD
authors.lastname: Graham
authors.forename: P B
authors.initials: PB
authors.lastname: Barker
authors.forename: W M
authors.initials: WM
authors.lastname: Brooks
authors.forename: D C
authors.initials: DC
authors.lastname: Morris
authors.forename: W
authors.initials: W
authors.lastname: Ahmed
authors.forename: E
authors.initials: E
authors.lastname: Bryniarski
authors.forename: D O
authors.initials: DO
authors.lastname: Hearshen
authors.forename: J A
authors.initials: JA
authors.lastname: Sanders
authors.forename: B A
authors.initials: BA
authors.lastname: Holshouser
authors.forename: C C
authors.initials: CC
authors.lastname: Turkel
mesh_terms: D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D003999:Dichloroacetic Acid / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D011522:Protons; D020521:Stroke / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology
chemical_list: D011522:Protons; D003999:Dichloroacetic Acid