Reactogenicity and immunogenicity of a Lyme disease vaccine in children 2-5 years old.
Two doses of a recombinant Lyme disease vaccine (15 and 30 microg) were administered to children 2-5 years old (0-1-month schedule) and were well tolerated. Both doses were highly immunogenic with geometric mean titers 1 month after vaccination of 4366 and 9877 ELISA units (EU)/mL, respectively. Nearly all subjects had antibody levels of > or = 1400 EU/mL, suggesting protective tick titre for one tick season.
Beran
J
J
Department of Epidemiology, Purkyne Military Medical Academy, Hradec Kralové, Czech Republic.
De Clercq
N
N
Dieussaert
I
I
Van Hoecke
C
C
D000907:Antibodies, Bacterial / Q000097:blood; D000954:Antigens, Surface / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001428:Bacterial Vaccines; D015748:Borrelia burgdorferi Group / Q000276:immunology; D002675:Child, Preschool; D006801:Humans; D008074:Lipoproteins; D008193:Lyme Disease / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D022123:Lyme Disease Vaccines / Q000009:adverse effects* / Q000235:genetics / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000276:immunology
D000907:Antibodies, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; D022123:Lyme Disease Vaccines; C072045:OspA protein; D014614:Vaccines, Synthetic