Microbiology of destructive periodontal disease in adolescent patients with congenital neutropenia. A report of 3 cases.
OBJECTIVE
Congenital neutropenia is one condition that may predispose for destructive periodontal disease at a young age. In this report, we describe the microbiology of 3 adolescent patients with congenital neutropenia two of whom suffered from severe periodontitis.


METHODS
Microbiological testing of the parents was also performed in 1 case. DNA fingerprinting was used to study transmission of putative periodontal pathogens in this case. From 1 patient with periodontitis, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were isolated; a 2nd periodontitis patient was infected with P. gingivalis. A 3rd patient had gingivitis only and no A. actinomycetemcomitans or P. gingivalis were found.


RESULTS
Using the amplified fragment length polymorphism DNA fingerprinting technique, bacterial transmission between the father and a patient was shown for A. actinomycetemcomitans but not for P. gingivalis.
van Winkelhoff
A J
AJ
Department of Oral Biology, Academic Centre for Dentistry Amsterdam, The Netherlands.
Schouten-van Meeteren
A Y
AY
Baart
J A
JA
Vandenbroucke-Grauls
C M
CM
D000189:Actinobacillus Infections / Q000635:transmission*; D000293:Adolescent; D016976:Aggregatibacter actinomycetemcomitans / Q000472:pathogenicity; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000032:analysis; D005220:Fathers; D005260:Female; D020022:Genetic Predisposition to Disease; D005891:Gingivitis / Q000382:microbiology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D009503:Neutropenia / Q000150:complications* / Q000151:congenital*; D010514:Periodontal Pocket / Q000382:microbiology; D010518:Periodontitis / Q000209:etiology* / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000472:pathogenicity
D004269:DNA, Bacterial