Transient hypoparathyroidism following successful treatment of hypercalcaemia of malignancy in a dog.
A 4-year-old, entire female, English Cocker Spaniel was presented for treatment of lymphosarcoma and secondary hypercalcaemia. After induction chemotherapy the dog became severely hypocalcaemic and showed signs of weakness, muscle fasciculation and facial pruritus. Hormone analysis confirmed inadequate production of parathyroid hormone. Although hypocalcaemia has been previously reported as a component of tumour lysis syndrome, it has not been associated with transient parathyroid hormone deficiency.
Horn
B
B
School of Veterinary Clinical Science, Division of Veterinary and Biomedical Sciences, Murdoch University, Western Australia.
Irwin
P J
PJ
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D004285:Dogs; D005260:Female; D006934:Hypercalcemia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D007011:Hypoparathyroidism / Q000139:chemically induced / Q000662:veterinary*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D010281:Parathyroid Hormone / Q000097:blood; D015275:Tumor Lysis Syndrome / Q000209:etiology / Q000662:veterinary*
D010281:Parathyroid Hormone