[Polyenic acid 5-hydroxytryptamides and 3-hydroxytyramides as tools for studying of the pre-nervous biogenic monoamine functions].
Three main effects of the amides on embryos of opistobranch molluscs, sea urchins and starfish, were revealed. First, a rather independent and clear protective action of 5-HYDROXYTRYPTAMIDES AND 3-HYDROXYTYRAMIDES against cytostatic antagonists of serotonin and dopamine, resp. Second, prevention of developmental abnormalities induced by protein kinase C activators both by hydroxytryptamides and hydroxytyramides. Third, the cytostatic effect of 3-HYDROXYTRIPTAMIDES eliminated or prevented by 5-HYDROXYTRYPTAMIDES. These effects quantitatively depended on the structure of their fatty acids part. Some functionally active regulatory substances similar to 5-HYDROXYTRYPTAMIDES AND 3-HYDROXYTYRAMIDES may exist in the early embryos.
Buznikov
G A
GA
Koltzov Institute of Developmental Biology, Russian Acad. Sci., Moscow, Russia.
Bezuglov
V V
VV
D000577:Amides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000737:chemistry / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004625:Embryo, Nonmammalian; D004789:Enzyme Activation; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000502:physiology*; D008974:Mollusca / Q000196:embryology / Q000502:physiology*; D011493:Protein Kinase C / Q000378:metabolism; D012617:Sea Urchins / Q000196:embryology / Q000502:physiology*; D012701:Serotonin / Q000737:chemistry / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D013215:Starfish / Q000196:embryology / Q000502:physiology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000577:Amides; D018492:Dopamine Antagonists; D005231:Fatty Acids, Unsaturated; D012702:Serotonin Antagonists; D012701:Serotonin; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate; D004298:Dopamine