Glucose-dependent insulinotropic peptide signaling pathways in endothelial cells.
Glucose-dependent insulinotropic peptide (GIP) potentiates glucose-induced insulin secretion. In addition, GIP has vasoconstrictive or vasodilatory properties depending on the vascular bed affected. In order to assess whether this effect could be related to differences in GIP receptor expression, several different endothelial cell types were examined for GIP receptor expression. GIP receptor splice variants were detected and varied depending on the endothelial cell type. Furthermore, stimulation of these cells with GIP led to cell type dependent differences in activation of the calcium and cAMP signaling pathways. To our knowledge this is the first physiological characterization of receptors for GIP in endothelial cells.
Zhong
Q
Q
Institute of Molecular Medicine and Genetics, Dept. of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.
Bollag
R J
RJ
Dransfield
D T
DT
Gasalla-Herraiz
J
J
Ding
K H
KH
Min
L
L
Isales
C M
CM
D017398:Alternative Splicing; D001011:Aorta / Q000166:cytology; D001775:Blood Circulation; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004730:Endothelium, Vascular / Q000502:physiology*; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism*; D011651:Pulmonary Artery / Q000166:cytology; D012333:RNA, Messenger / Q000302:isolation & purification; D011964:Receptors, Gastrointestinal Hormone / Q000235:genetics / Q000302:isolation & purification*; D014018:Tissue Distribution; D014471:Umbilical Veins / Q000166:cytology
D010446:Peptide Fragments; D012333:RNA, Messenger; D011964:Receptors, Gastrointestinal Hormone; C101760:gastric inhibitory polypeptide (1-42); D005749:Gastric Inhibitory Polypeptide; C041086:gastric inhibitory polypeptide receptor; D017868:Cyclic AMP-Dependent Protein Kinases; D002118:Calcium