title: Renal blood flow regulation, autoregulation, and vasomotor nephropathy.
abstract: Renal blood flow and renal perfusion pressure are regulated by two control mechanisms. The first, extrinsic, actually involves a complex interaction of vasomotor effects between opposing neurohormonal systems. The second, intrinsic mechanism, renal autoregulation, depends on changes in afferent arteriolar tone in response to the renal perfusion pressure itself. This article reviews these two mechanisms, how they normally respond to stress, and the clinical implications of certain situations in which these control mechanisms are disrupted.
authors.affiliation: Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York, USA. rs543@columbia.edu
authors.forename: R N
authors.initials: RN
authors.lastname: Sladen
authors.forename: D
authors.initials: D
authors.lastname: Landry
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D006706:Homeostasis; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000209:etiology / Q000503:physiopathology*; D007683:Kidney Tubular Necrosis, Acute / Q000503:physiopathology; D017093:Liver Failure / Q000150:complications / Q000503:physiopathology; D012079:Renal Circulation / Q000502:physiology*; D012772:Shock, Septic / Q000150:complications / Q000503:physiopathology; D014661:Vasoconstriction; D014666:Vasomotor System / Q000503:physiopathology*