title: 5-[1'-(2'-N-Arylsulfonyl-1',2',3',4'-tetrahydroisoquinolyl)]-4, 5-dihydro-2(3H)-furanones: positive allosteric modulators of the GABA(A) receptor with a new mode of action.
authors.affiliation: Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: R
authors.initials: R
authors.lastname: Razet
authors.forename: U
authors.initials: U
authors.lastname: Thomet
authors.forename: R
authors.initials: R
authors.lastname: Furtmüller
authors.forename: A
authors.initials: A
authors.lastname: Chiaroni
authors.forename: E
authors.initials: E
authors.lastname: Sigel
authors.forename: W
authors.initials: W
authors.lastname: Sieghart
authors.forename: R H
authors.initials: RH
authors.lastname: Dodd
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D001921:Brain / Q000378:metabolism; D004594:Electrophysiology; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018757:GABA Modulators / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008968:Molecular Conformation; D009865:Oocytes / Q000378:metabolism / Q000502:physiology; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines; D014981:Xenopus
chemical_list: C416384:1-(2,3,4,5-tetrahydro-5-oxo-2-furyl)-2-N-(p-toluenesulfonyl)-1,2,3,4-tetrahydroisoquinoline; D005663:Furans; D018757:GABA Modulators; D007546:Isoquinolines; D011963:Receptors, GABA-A; D044005:Tetrahydroisoquinolines