The effects of pollutants on the allergic immune response.
An increase in the prevalence of allergy and allergic diseases has taken place in the industrialised countries. Allergic diseases represent a major health problem, and appear linked to affluence and modern lifestyle. In the 20th century air pollution from industrial sources largely has been replaced by diesel exhaust and other traffic pollution. Further, the indoor environment in which we spend most of our time has changed dramatically. In order to understand the contribution of pollution and other environmental changes to the development of allergy, we need to understand the biologic processes that underlie allergic immune responses. In the present paper, immune regulatory pathways that control the allergic immune response are delineated. Castor bean dust causes widespread allergic sensitisation. The investigations that made clear the importance of CD8 T cells for the regulation of IgE production were triggered by studies of castor bean allergy. A special focus is in this review placed on the regulatory role of CD8 T cells in the development of the allergic immune response.
Kemeny
D M
DM
Department of Immunology, Guy's, King's and St. Thomas's School of Medicine, Rayne Institute, 123 Coldharbour Lane, SE5 9NU, London, United Kingdom.
D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000096:biosynthesis; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000276:immunology
D016207:Cytokines; D004785:Environmental Pollutants; D007073:Immunoglobulin E