title: CSF levels of tau, beta-amyloid(1-42) and GAP-43 in frontotemporal dementia, other types of dementia and normal aging.
abstract: Cerebrospinal fluid (CSF) levels of tau, beta-amyloid(1-42) and growth-associated protein 43 (GAP-43) were studied in patients with frontotemporal dementia (FTD; n = 17), Alzheimer's disease (AD; n = 60), subcortical white-matter dementia (SWD; n = 24), Parkinson's disease (PD; n = 23) and dysthymia (n = 19) and in age-matched controls (n = 32). CSF-tau was significantly increased only in AD, and CSF-beta-amyloid(1-42) was significantly decreased in AD and SWD as compared to controls, and in AD compared to FTD. CSF-GAP-43 was significantly decreased only in PD. The GAP-43/tau ratio was decreased in all the patient groups except the dysthymia group compared to controls. A positive correlation was found between CSF-GAP-43 and CSF-tau in all groups. The results suggest normal levels of CSF-tau and CSF-beta-amyloid(1-42) in FTD, which will aid in the clinical separation of FTD from AD. In SWD, decreased levels of CSF-beta-amyloid(1-42) suggest concomitant involvement of vascular and amyloid protein mechanisms.
authors.affiliation: Institute of Clinical Neuroscience, Göbteborg University, Sahlgrenska University Hospital, Mölndal, Sweden. magnus.sjogren@medfak.gu.se
authors.forename: M
authors.initials: M
authors.lastname: Sjögren
authors.forename: L
authors.initials: L
authors.lastname: Minthon
authors.forename: P
authors.initials: P
authors.lastname: Davidsson
authors.lastname: Granérus A-K
authors.forename: A
authors.initials: A
authors.lastname: Clarberg
authors.forename: H
authors.initials: H
authors.lastname: Vanderstichele
authors.forename: E
authors.initials: E
authors.lastname: Vanmechelen
authors.forename: A
authors.initials: A
authors.lastname: Wallin
authors.forename: K
authors.initials: K
authors.lastname: Blennow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000134:cerebrospinal fluid; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid*; D000704:Analysis of Variance; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016009:Chi-Square Distribution; D003704:Dementia / Q000134:cerebrospinal fluid*; D005260:Female; D019922:GAP-43 Protein / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000134:cerebrospinal fluid*; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015415:Biomarkers; D019922:GAP-43 Protein; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins