Chemical synthesis of a core 2 branched pentasaccharide containing a carboxylate group.
Design and synthesis of a carboxylate-containing pentasaccahride 1 with the Galbeta(1-4) (Fucalpha1-3)GlcNAcbeta(1-6)[3-[1-carboxymethyl]-Galbeta+ ++(1-3)]GalNAcalpha-OMe sequence, which is obtained through regioselective coupling of the 6-OH of a novel acceptor 9 with Lewis(x) donor 10 catalyzed by NIS-TfOH are described.
Xia
J
J
Molecular & Cellular Biophysics, Roswell Park Cancer Institute, Buffulo, NY 14263, USA.
Alderfer
J L
JL
Matta
K L
KL
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002264:Carboxylic Acids / Q000032:analysis* / Q000737:chemistry; D008024:Ligands; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D019087:Selectins / Q000378:metabolism
D002264:Carboxylic Acids; D008024:Ligands; D011134:Polysaccharides; D019087:Selectins