[The possible role of genetic factors in the cholesterol high density lipoprotein level in the Moscow population].
The study was aimed at clarifying the relative roles of genetic and environmental factors in determination of the blood concentration of high density lipoprotein cholesterol (HDL-C) in the Russian population. For this purpose, some polymorphic systems of the apolipoproteins B, CII, and CIII; cholesterol ether transport protein (CETP); and lecithin-cholesterol acyltransferase (LCAT) genes were compared in two groups of males living in Moscow who had high and low blood HDL-C concentrations (less than 40 and more than 50 mg/dl, respectively). No statistically significant differences were found between distributions of the allelic variants of the genes studied in males with different blood HDL-C concentrations. Thus, the given panel of proteins connected with the metabolism of blood plasma lipids has no effect on the blood HDL-C concentration in Russian males from the Moscow population.
Slominskiĭ
P A
PA
Department of Molecular Bases of Human Genetics, Russian Academy of Sciences, Moscow, Russia. slomin@img.ras.ru
Metel'skaia
V A
VA
Miloserdova
O V
OV
Perova
N V
NV
Limborskaia
S A
SA
D000328:Adult; D001053:Apolipoproteins / Q000097:blood / Q000235:genetics; D002352:Carrier Proteins / Q000097:blood / Q000235:genetics; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood* / Q000235:genetics; D008078:Cholesterol, LDL / Q000097:blood; D006023:Glycoproteins; D006801:Humans; D008297:Male; D008875:Middle Aged; D009031:Moscow; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood / Q000235:genetics; D011110:Polymorphism, Genetic
D001053:Apolipoproteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006023:Glycoproteins; D007862:Phosphatidylcholine-Sterol O-Acyltransferase