Hypothesis regarding a membrane-associated mechanism of biological action due to low-dose ionizing radiation.
A novel theory is proposed regarding the action of ionizing radiation in the range of very low doses. The basic premise of the theory presented is that the low-dose effect cannot be explained by direct damage to the DNA (as has generally been assumed) and that effects on cellular membranes should be considered instead. Low-dose radiation damaging the plasma membrane decreases the concentration of low-molecular weight compounds (LMWC) inside the cell, which through an unspecific mechanism induces an activation of all enzymes. The mechanism described here has been well substantiated. The changes in the intracellular contents of LMWC and the increase of pH(in) cause chromatin rearrangements, alterations in DNA folding and finally, if the latter are strong enough, expression of various "silent" genes including repair enzyme genes.
Eidus
L K
LK
Laboratory of Regulation of Proliferation and Cell Death, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region. zaichkina@venus.iteb.serpukhov.su
D000818:Animals; D002462:Cell Membrane / Q000528:radiation effects*; D002478:Cells, Cultured; D006224:Cricetinae; D004247:DNA / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006367:HeLa Cells; D001467:Hordeum / Q000166:cytology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008962:Models, Theoretical; D011839:Radiation, Ionizing; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D013950:Thymus Gland / Q000166:cytology / Q000528:radiation effects; D013997:Time Factors
D004247:DNA