Hemofiltration in sepsis: where do we go from here?
Hemofiltration as an adjunct to therapy for sepsis is now 10 years old. Despite early successes and significant theoretical advantages, the treatment remains experimental. Although feasibility has been established, efficacy has proved to be much more difficult. Clinical as well as technical difficulties remain important considerations to future studies. These issues are discussed and the brief history of hemofiltration in sepsis is reviewed.
Kellum
J A
JA
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Kellumja@anes.upmc.edu
Bellomo
R
R
D003422:Critical Care / Q000379:methods; D016638:Critical Illness; D005240:Feasibility Studies; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D008297:Male; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000628:therapy*; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000175:diagnosis / Q000628:therapy*