title: Progression of primary biliary cirrhosis after proctocolectomy for ulcerative colitis.
abstract: We report a case of progression of primary biliary cirrhosis (PBC) after proctocolectomy for ulcerative colitis. A 43-year-old woman underwent a total proctocolectomy after being diagnosed with ulcerative colitis. In the course of the preoperative investigation, liver function test results were within the normal range. Four months after the proctocolectomy, the patient showed a high level of alkaline phosphatase (2398 IU/l) and a positive anti-mitochondrial antibody titer (>1:160). There were no associated symptoms. A liver biopsy demonstrated expansion of all portal areas by infiltrates of lymphocytes and histiocytes. These appearances indicated chronic biliary disease and were compatible with PBC. The association of PBC and ulcerative colitis is rare. However, a review of the recent literature suggests that PBC and ulcerative colitis may be associated; this combination should be kept in mind.
authors.affiliation: First Department of Surgery, Faculty of Medicine, Hiroshima University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ohge
authors.forename: Y
authors.initials: Y
authors.lastname: Takesue
authors.forename: T
authors.initials: T
authors.lastname: Yokoyama
authors.forename: E
authors.initials: E
authors.lastname: Hiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Murakami
authors.forename: Y
authors.initials: Y
authors.lastname: Imamura
authors.forename: F
authors.initials: F
authors.lastname: Shimamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuura
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications / Q000601:surgery*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000473:pathology*; D016737:Proctocolectomy, Restorative