Inherited infantile dilated cardiomyopathy in dogs: genetic, clinical, biochemical, and morphologic findings.
Dilated cardiomyopathy, a lethal disease characterized by left ventricular dilation and systolic dysfunction, is relatively common in humans and other mammals. Idiopathic dilated cardiomyopathy (IDCM) is a primary myocardial disease of unknown cause and can be a familial disorder. This report describes autosomal recessive IDCM in dogs. It occurs in Portuguese Water Dog (PWD) pups and is manifested by acute, vague clinical signs and sudden death. Affected pups have progressive reduction of fractional shortening that can be demonstrated by echocardiography prior to the development of clinical signs. Furthermore, these pups have low plasma taurine levels when consuming certain diets. Affected pups had dilation of the left ventricle and alterations in the sarcomere appearance, while immunohistochemical and biochemical studies demonstrate an increase in desmin, a cytoskeleton protein. The clinical and morphologic findings of IDCM in PWDs are distinct from those reported in adult IDCM. Finally, the clinical and echocardiographic manifestations were reversible in some pups following oral taurine supplementation for 2 months. These results suggest that IDCM in PWDs is correlated with low plasma taurine levels.
Alroy
J
J
Department of Pathology, Tufts University Schools of Medicine and Veterinary Medicine, and New England Medical Center, Boston, Massachusetts 02111, USA. Alroy@FacStaff@VET
Rush
J E
JE
Freeman
L
L
Amarendhra Kumar
M S
MS
Karuri
A
A
Chase
K
K
Sarkar
S
S
D000818:Animals; D000831:Animals, Newborn; D002311:Cardiomyopathy, Dilated / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D003893:Desmin / Q000032:analysis; D004283:Dog Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004285:Dogs; D005260:Female; D018703:Founder Effect; D006352:Heart Ventricles / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D007150:Immunohistochemistry; D007178:Inbreeding; D008297:Male; D008854:Microscopy, Electron; D013654:Taurine / Q000097:blood / Q000493:pharmacokinetics
D003893:Desmin; D013654:Taurine