Association between acute hypobaric hypoxia and activation of coagulation in human beings.
The risk of venous thrombosis is thought to be increased by flying. In a study of 20 healthy male volunteers who were suddenly exposed to a hypobaric environment similar to that encountered within aeroplane cabins, markers of activated coagulation transiently Increased by two-fold to eight-fold. We suggest that hypobaric hypoxia, with sedentariness and dehydration, may cause this increased risk of venous thrombosis.
Bendz
B
B
Rostrup
M
M
Sevre
K
K
Andersen
T O
TO
Sandset
P M
PM
D000208:Acute Disease; D000328:Adult; D000399:Air Pressure; D000401:Aircraft; D001273:Atmosphere Exposure Chambers; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000032:analysis; D003681:Dehydration / Q000150:complications; D006801:Humans; D000860:Hypoxia / Q000097:blood*; D008297:Male; D012307:Risk Factors; D020246:Venous Thrombosis / Q000209:etiology*
D001779:Blood Coagulation Factors