Dendritic cells: new roles for Cdc42 and Rac in antigen uptake?
In dendritic cells, macropinocytosis is downregulated during maturation and antigen presentation. New studies indicate a key role for Rho-family GTPases in this regulation, but what these proteins are actually doing remains a mystery.
Nobes
C
C
MRC Laboratory for Molecular Cell Biology, University College London, UK. c.nobes@ucl.ac.uk
Marsh
M
M
D000818:Animals; D000941:Antigens / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000502:physiology; D010873:Pinocytosis; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism*; D020744:rac GTP-Binding Proteins / Q000378:metabolism*
D000941:Antigens; D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins