Hijacking a chaperone: manipulation of the MHC class II presentation pathway.
Novel antigen delivery systems are currently being developed by genetic manipulation of the MHC class II trafficking pathway. Specific targeting of endogenously synthesized antigens to the class II loading compartment can result in massively enhanced presentation of peptide epitopes. This emerging technology holds promise for a variety of clinical applications including vaccine development, cancer therapies and control of autoimmune diseases.
Koch
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Division of Immunobiology, University of Bonn, Römerstrasse 164, D53117, Bonn, Germany.
van Driel
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Gleeson
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PA
D000818:Animals; D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000378:metabolism; D015551:Autoimmunity; D001665:Binding Sites; D000939:Epitopes / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology
D000951:Antigens, Neoplasm; D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D018832:Molecular Chaperones; D019444:Vaccines, DNA