Redox regulation of the nuclear receptor.
Redox regulation is currently considered a mode of signal transduction for coordinated regulation of a variety of cellular processes. Transcriptional regulation of gene expression is also influenced by the cellular redox state, for example, through the oxidoreductive modification of transcription factors. The nuclear receptors act as ligand-dependent transcription factors and are considered to be one of the key regulators of essential biological processes. Using a glucocorticoid receptor as a model, we show that redox regulation of receptor function is one of the dynamic cellular responses to environmental stimuli.
Tanaka
H
H
Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Japan. hirotnk@ims.u-tokyo.ac.jp
Makino
Y
Y
Okamoto
K
K
Iida
T
T
Yoshikawa
N
N
Miura
T
T
D000818:Animals; D004273:DNA, Neoplasm / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011965:Receptors, Glucocorticoid / Q000378:metabolism
D004273:DNA, Neoplasm; D006360:Heat-Shock Proteins; D011965:Receptors, Glucocorticoid