HLA-DRB1 alleles in Kuwaiti children with idiopathic nephrotic syndrome.
We have studied the effect of HLA-DRB1 alleles on the clinical presentation of 61 Kuwaiti Arab children with idiopathic nephrotic syndrome. DR7(*0701) was the most prevalent DR allele, found in 41/61 patients (67%) compared with 10/59 healthy controls (17%) (p<0.001). DR3(*0301-0308) allele was the second most common, found in 25% of patients compared with 26% of controls (not significant). There was no significant difference between DRB1*0701(DR7)-positive and DRB1*0701-negative patients in terms of steroid sensitivity, steroid dependency, or steroid resistance. Nevertheless, the former group had a significantly lower mean age of onset (35 months vs 53 months) and a shorter remission period following treatment with cyclophosphamide or chlorambucil (8 months vs 29 months). Our data highlight the role of the DRB 1*0701 allele in predisposing Kuwaiti Arab children with idiopathic nephrotic syndrome to a more prolonged course of the disease.
Al-Eisa
A A
AA
Pediatric Department, Faculty of Medicine, Kuwait University, Safat. Amal@hsc.kuniv.edu.kw
Haider
M Z
MZ
Srivasta
B S
BS
D017668:Age of Onset; D000483:Alleles; D018912:Arabs; D002648:Child; D018450:Disease Progression; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007668:Kidney / Q000473:pathology; D007730:Kuwait; D009404:Nephrotic Syndrome / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D012016:Reference Values
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains