title: Laparoscopy with ultrasonographic guidance of intraamniotic methotrexate injection for ectopic pregnancy. A report of two cases.
abstract: BACKGROUND
  The efficacy of laparoscopic intratubal injection of methotrexate is reportedly controversial.
  
  
  METHODS
  A 29-year-old woman with an interstitial-isthmic pregnancy and a 30-year-old woman with an ampullary pregnancy surrounded by dense adhesions were treated with intraamniotic injection of methotrexate with ultrasonographically guided laparoscopy (LUS). The ectopic pregnancies resolved quickly, without further intervention. The human chorionic gonadotropin concentrations were negligible by 18 and 25 days.
  
  
  CONCLUSIONS
  Intraamniotic methotrexate injection with LUS is an effective treatment for unruptured interstitial and tubal pregnancies in patients with dense adhesions.
authors.affiliation: Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan. s-akira@nms.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Akira
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: A
authors.initials: A
authors.lastname: Yamanaka
authors.forename: T
authors.initials: T
authors.lastname: Takeshita
authors.forename: H
authors.initials: H
authors.lastname: Kaseki
authors.forename: T
authors.initials: T
authors.lastname: Araki
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000328:Adult; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D010535:Laparoscopy / Q000379:methods; D008727:Methotrexate / Q000008:administration & dosage*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000517:prevention & control* / Q000601:surgery*; D014463:Ultrasonography
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate