Inhibitory effects of Indole-3-carbinol on invasion and migration in human breast cancer cells.
Indole-3-carbinol (I3C) is a promising phytochemical agent in chemoprevention of breast cancer. Our present study is the first description of I3C that significantly inhibits the cell adhesion, spreading and invasion associated with an up-regulation of PTEN (a tumor suppressor gene) and E-cadherin (a regulator of cell-cell adhesion) expression in T47-D human breast cancer cells. Therefore, I3C exhibits anti-cancer activities by suppressing breast tumor cell growth and metastatic spread. Metastatic breast cancer is a devastating problem, clinical application of I3C as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.
Meng
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Department of Radiation Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11042, USA.
Goldberg
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ID
Rosen
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EM
Fan
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D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology* / Q000517:prevention & control; D015820:Cadherins / Q000032:analysis; D002448:Cell Adhesion; D002465:Cell Movement; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D009361:Neoplasm Invasiveness; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins
D016588:Anticarcinogenic Agents; D015820:Cadherins; D007211:Indoles; D025521:Tumor Suppressor Proteins; C016517:indole-3-carbinol; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human