Different manifestations of langerhans cell histiocytosis affecting two members of a family.
Two different manifestations of Langerhans cell histiocytosis (histiocytosis X) are presented, the first occurring as a solitary rib eosinophil granuloma in an 11-year-old girl, and the second as an eosinophil granuloma of the lung of her mother, a 41-year-old heavy smoker, appearing 8 years after the onset of her daughter's disease. Familial clustering of two different manifestations of histiocytosis X disease is very rare and raises the possibility of inherited mutations that promote emergence of clonal Langerhans cells.
Balikó
Z
Z
Department of Respiratory Medicine, County Hospital, University Medical School, Pécs, Hungary. chelonae@mail.matav.hu
Schreiner
M
M
Kishindy
K K
KK
Hegedüs
G
G
Kosztolányi
G
G
D000328:Adult; D002648:Child; D005260:Female; D006680:HLA Antigens; D006646:Histiocytosis, Langerhans-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology
D006680:HLA Antigens