In vitro cytotoxic and antitumor property of Emilia sonchifolia (L.) DC in mice.
Methanolic extract of Emilia sonchifolia (Compositae), a folklore medicinal plant, was found to be cytotoxic to Daltons lymphoma (DL), Ehrlich ascites carcinoma (EAC) and mouse lung fibroblast (L-929) cells, but not toxic to normal human lymphocytes, under in vitro conditions. Oral administration of the extract (100 mg/kg, b. wt) to mice reduced the development of both solid and ascites tumors and increased the life span of these tumor bearing mice. Further, the extract inhibited DNA synthesis as judged from a reduction in tritiated thymidine incorporation into DL cells under in vitro conditions.
Shylesh
B S
BS
Amala Cancer Research Centre, Amala Nagar P.O., Thrissur 680 553, Kerala, India.
Padikkala
J
J
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts