Decreased striatal dopaminergic innervation in REM sleep behavior disorder.
REM sleep behavior disorder (RBD) is a possible herald of neurodegenerative disorders with parkinsonism. The authors determined the density of striatal dopaminergic terminals with [11C]dihydrotetrabenazine PET in six elderly subjects with chronic idiopathic RBD and 19 age-appropriate controls. In subjects with RBD, there were significant reductions in striatal [11C]dihydrotetrabenazine binding, particularly in the posterior putamen.
Albin
R L
RL
Department of Neurology, University of Michigan, Ann Arbor, USA. ralbin@umich.edu
Koeppe
R A
RA
Chervin
R D
RD
Consens
F B
FB
Wernette
K
K
Frey
K A
KA
Aldrich
M S
MS
D000368:Aged; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D004298:Dopamine / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020187:REM Sleep Behavior Disorder / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
D004298:Dopamine