PAcM-AN: poly (N-acryloylmorpholine)-conjugated antisense oligonucleotides.
A new amphiphilic, high-molecular weight poly (N-acryloylmorpholine) (PAcM) polymer has been used to be linked to oligonucleotide chains through a liquid-phase stepwise synthesis. This new conjugate has been investigated for its melting property, nuclease stability and capacity to elicit RNase H activity. Its antisense activity against an HIV-1 target has been also evaluated.
Bonora
G M
GM
Dept. of Chemical Sciences, University of Trieste, Italy.
De Franco
A M
AM
Rossin
R
R
Veronese
F M
FM
Ferruti
P
P
Plyasunova
O
O
Vorobjev
P E
PE
Pyshnyi
D V
DV
Komarova
N I
NI
Zarytova
V F
VF
D005786:Gene Expression Regulation / Q000187:drug effects; D005960:Glucosides; D007288:Inosine / Q000031:analogs & derivatives; D015394:Molecular Structure; D008970:Molecular Weight; D009025:Morpholines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009691:Nucleic Acid Denaturation; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry; D016914:Ribonuclease H / Q000378:metabolism*; D012995:Solubility
C421447:1-glucopyranosylinosine-5',6'-diphosphate; D005960:Glucosides; D009025:Morpholines; D016376:Oligonucleotides, Antisense; D011092:Polyethylene Glycols; D007288:Inosine; C028210:monomethoxypolyethylene glycol; D016914:Ribonuclease H