Influence of age and K, Mg aspartate (Cardilan) on murine haemopoiesis.
We have studied the effect of age as well as the effect of short-term and long-term intake of K and Mg salts of aspartic acid (Cardilan) on haemopoiesis in ICR mice strain. The cellularity of the bone marrow does not change with aging, but the number of granulocyte-macrophage colony-forming cells (GM-CFC) and also the number of spleen colony-forming units (CFU-S) and erythroid burst-forming units (BFU-E) in two-year-old mice increased in the bone marrow. In two-year-old mice the number of leukocytes decreased in the peripheral blood with aging, mainly as a result of a decrease in mononuclear cells. Short-term drinking (STD) of Cardilan caused increased numbers of CFU-S and BFU-E in bone marrow and increased numbers of reticulocytes in the peripheral blood of one-year old animals (STD/12 months old). In the oldest mice (STD/24) increased weight and cellularity of the spleen and rapid increase of leukocytes and reticulocytes in the peripheral blood was recorded. After long-term drinking (LTD) of Cardilan the number of spleen GM-CFC rose markedly in one-year-old mice (LTD/12) and in two-year-old mice (LTD/24) the number of reticulocytes in the peripheral blood rose. Our results indicate that K and Mg salts of aspartic acid influence erythropoietic activity most widely.
Fedorocko
P
P
Department of Cellular and Molecular Biology, Faculty of Sciences, P. J. Safárik University, Moyzesova 11, 04167, Kosice, Slovak Republic. fedvox@kosice.upjs.sk
Macková
N O
NO
Sándorcínová
Z
Z
Sedláková-Hoferová
Z
Z
Solár
P
P
Chlebovský
O
O
D000375:Aging / Q000502:physiology*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism* / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008274:Magnesium; D051379:Mice; D008813:Mice, Inbred ICR; D009525:Niacin / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D011188:Potassium
D009525:Niacin; D001224:Aspartic Acid; C100123:nicofuranose; D008274:Magnesium; D011188:Potassium