title: Detergents in the indoor environment - what is the evidence for an allergy promoting effect? Known and postulated mechanisms.
abstract: IgE-mediated allergic diseases, such as asthma and rhinitis seem to be increasing in industrialised societies. One possible explanation for this could be the increased use of more effective and aggressive detergents. The surfactants from these could interfere with the sensitisation process in which specific IgE is formed to ubiquitously occurring environmental allergens. Only sparse data exist in relation to surfactants and allergic sensitization. However, it can be speculated that the strong surfactant properties of some of ingredients used in modem detergents may interfere with some of the intricate cellular interactions taking place along the immunological pathways. These include formation of IL-4 and IL-5 producing T helper lymphocytes type 2 and the B-lymphocyte isotype switch, which leads to production of specific IgE. Candidates for experimental studies of such phenomena on the cellular level are proposed.
authors.affiliation: Laboratory of Medical Allergology Allergy Unit, National University Hospital, Blegdamsvej 9, Department 7542, DK-2100, Copenhagen, Denmark. lkpallgy@inet.uni2.dk
authors.forename: L K
authors.initials: LK
authors.lastname: Poulsen
authors.forename: S K
authors.initials: SK
authors.lastname: Clausen
authors.forename: C
authors.initials: C
authors.lastname: Glue
authors.forename: A
authors.initials: A
authors.lastname: Millner
authors.forename: G D
authors.initials: GD
authors.lastname: Nielsen
authors.forename: T
authors.initials: T
authors.lastname: Jinquan
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000818:Animals; D002454:Cell Differentiation; D016207:Cytokines / Q000096:biosynthesis; D003902:Detergents / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D017578:Immunoglobulin Class Switching; D007073:Immunoglobulin E / Q000096:biosynthesis
chemical_list: D016207:Cytokines; D003902:Detergents; D007073:Immunoglobulin E