title: Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756.
abstract: The in vitro spectrum of a novel des-fluoro(6) quinolone, BMS-284756, was compared with those of five fluoroquinolones (trovafloxacin, moxifloxacin, levofloxacin, ofloxacin, and ciprofloxacin). BMS-284756 was among the most active and often was the most active quinolone against staphylococci (including methicillin-resistant strains), streptococci, pneumococci (including ciprofloxacin-nonsusceptible and penicillin-resistant strains), and Enterococcus faecalis. BMS-284756 inhibited approximately 60 to approximately 70% of the Enterococcus faecium (including vancomycin-resistant) strains and 90 to 100% of the Enterobacteriaceae strains and gastroenteric bacillary pathogens at the anticipated MIC susceptible breakpoint (</=4 microg/ml). Against the nonfermenters, BMS-284756 inhibited 90 to 100% of Pseudomonas fluorescens, Pseudomonas stutzeri, Stenotrophomonas maltophilia, Flavobacterium spp., and Acinetobacter spp. and 72% of Pseudomonas aeruginosa strains at 4 microg/ml. Against anaerobic bacteria, BMS-284756 was among the most active, inhibiting essentially all strains tested. It had very low MICs against the fastidious and atypical microbial species, in particular against mycoplasmas or ureaplasmas, Borrelia burgdorferi, chlamydia, and gonococci. These results indicate that with its broad antibacterial spectrum, BMS-284756 should be evaluated clinically for the treatment of community and nosocomial infections.
authors.affiliation: Department of Microbiology, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, USA. fungtomj@bms.com
authors.forename: J C
authors.initials: JC
authors.lastname: Fung-Tomc
authors.forename: B
authors.initials: B
authors.lastname: Minassian
authors.forename: B
authors.initials: B
authors.lastname: Kolek
authors.forename: E
authors.initials: E
authors.lastname: Huczko
authors.forename: L
authors.initials: L
authors.lastname: Aleksunes
authors.forename: T
authors.initials: T
authors.lastname: Stickle
authors.forename: T
authors.initials: T
authors.lastname: Washo
authors.forename: E
authors.initials: E
authors.lastname: Gradelski
authors.forename: L
authors.initials: L
authors.lastname: Valera
authors.forename: D P
authors.initials: DP
authors.lastname: Bonner
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D024841:Fluoroquinolones; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007211:Indoles; D008826:Microbial Sensitivity Tests; D015363:Quinolones
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007211:Indoles; D015363:Quinolones; C419689:garenoxacin