Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease.
The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
Chapman
T
T
Washington University School of Medicine, St. Louis, MO 63110, USA.
McKeel
D W
DW
Morris
J C
JC
D048948:14-3-3 Proteins; D000328:Adult; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014446:Tyrosine 3-Monooxygenase / Q000134:cerebrospinal fluid*
D048948:14-3-3 Proteins; D014446:Tyrosine 3-Monooxygenase