title: Increased DNA binding specificity for antitumor ecteinascidin 743 through protein-DNA interactions?
authors.affiliation: Departamento de Farmacología, Universidad de Alcalá, E-28871 Madrid, Spain, and Pharma Mar, Tres Cantos, E-28760 Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: García-Nieto
authors.forename: I
authors.initials: I
authors.lastname: Manzanares
authors.forename: C
authors.initials: C
authors.lastname: Cuevas
authors.forename: F
authors.initials: F
authors.lastname: Gago
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry; D004149:Dioxoles / Q000737:chemistry* / Q000378:metabolism; D051766:Early Growth Response Protein 1; D006801:Humans; D017874:Immediate-Early Proteins; D007546:Isoquinolines / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016329:Sp1 Transcription Factor / Q000737:chemistry; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin; D014157:Transcription Factors / Q000737:chemistry; D016335:Zinc Fingers
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018906:Antineoplastic Agents, Alkylating; D004268:DNA-Binding Proteins; D004149:Dioxoles; C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D017874:Immediate-Early Proteins; D007546:Isoquinolines; D016329:Sp1 Transcription Factor; D044005:Tetrahydroisoquinolines; D014157:Transcription Factors; D004247:DNA; D000077606:Trabectedin