Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports.
A replacement of the acetic acid moiety by valeric acid within the 4-hydroxymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labile resin linkage agents for use in solid phase peptide synthesis. Int. J. Peptide Protein Res. 1982; 20: 451-454) significantly improved its performance in terms of loading capacity, yield and purity of the final products. The results indicated the spacer-linker combination and type of solid supports are important factors for solid-phase synthesis.
Bui
C T
CT
Mimotopes Pty. Ltd., Clayton, Victoria, Australia.
Ercole
F
F
Pham
Y
Y
Campbell
R
R
Rasoul
F A
FA
Maeji
N J
NJ
Ede
N J
NJ
D001671:Biochemistry / Q000379:methods*; D006016:Glycolates / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D012116:Resins, Plant
D006016:Glycolates; D010455:Peptides; D012116:Resins, Plant; C036786:4-hydroxymethylphenoxyacetic acid