Naturally occurring V1-env region variants mediate simian immunodeficiency virus SIVmac escape from high-titer neutralizing antibodies induced by a protective subunit vaccine.
Macaques which developed high-titer neutralizing antibodies (htNAb) after immunization with a virion-derived oligomeric envelope glycoprotein subunit vaccine were protected against a homologous simian immunodeficiency virus SIVmac challenge. Here we demonstrate that the htNAb could be overcome by V1-env region variants isolated ex vivo from an SIVmac-infected macaque. The results further suggest that the development of V1-env region neutralization escape mutants is also necessary for survival of the virus in infected macaques. The immunological capacity of a single variable region to induce neutralizing antibodies in vaccinated and infected macaques initiate new ideas for a successful vaccine strategy.
Petry
H
H
Department of Virology and Immunology, German Primate Center, D-37077 Göttingen, Germany. hpetry@www.dpz.gwdg.de
Pekrun
K
K
Hunsmann
G
G
Jurkiewicz
E
E
Lüke
W
W
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D019556:COS Cells; D015686:Gene Products, env / Q000276:immunology*; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D021122:Protein Subunits; D018449:SAIDS Vaccines / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D014611:Vaccination; D014779:Virus Replication
D000914:Antibodies, Viral; D015686:Gene Products, env; D021122:Protein Subunits; D018449:SAIDS Vaccines