title: Formation of 9,10-unsaturation in the mitomycins: facile fragmentation of beta-alkyl-beta-aryl-alpha-oxo-gamma-butyrolactones.
abstract: A facile fragmentation of beta-alkyl-beta-aryl-alpha-oxo-gamma-butyrolactones is reported. A study to assist in the elucidation of the mechanism of the reaction is also revealed.
authors.affiliation: Sterling Chemistry Laboratory, Yale University, New Haven, Connecticut 06511-8118, USA. frederick.ziegler@yale.edu
authors.forename: F E
authors.initials: FE
authors.lastname: Ziegler
authors.forename: M Y
authors.initials: MY
authors.lastname: Berlin
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: A R
authors.initials: AR
authors.lastname: Looker
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D002087:Butyrates / Q000737:chemistry*; D007202:Indicators and Reagents; D007783:Lactones / Q000737:chemistry*; D008937:Mitomycins / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000903:Antibiotics, Antineoplastic; D002087:Butyrates; D007202:Indicators and Reagents; D007783:Lactones; D008937:Mitomycins