Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis.
Synovial fibroblasts occur as two phenotypes--intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase (UDPGD), vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF). These gene products contribute to specialised functions relating to tissue movement and leucocyte traffic.
Edwards
J C
JC
UCL Centre for Rheumatology, London, UK. jo.edwards@ucl.ac.uk
D000818:Animals; D001168:Arthritis / Q000378:metabolism* / Q000503:physiopathology; D002454:Cell Differentiation / Q000276:immunology*; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D013583:Synovial Membrane / Q000196:embryology* / Q000378:metabolism