title: Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
abstract: Two new 5,8'-coupled naphthylisoquinoline alkaloids, ancistroealaines A (1) and B (2), eleutherolic acid (3), and two naphthoic acids, ancistronaphthoic acid A (4) and B (5), have been isolated from Ancistrocladus ealaensis. Their structures were determined by spectroscopic, chemical, and chiroptical methods. Ancistroealaine A (1) exhibited activity against Leishmania donovani and Trypanosoma cruzi in vitro.
authors.affiliation: Institut für Organische Chemie der Universität, Am Hubland, D-97074 Würzburg, Germany. bringman@chemie.uni-wuerzburg.de
authors.forename: G
authors.initials: G
authors.lastname: Bringmann
authors.forename: A
authors.initials: A
authors.lastname: Hamm
authors.forename: C
authors.initials: C
authors.lastname: Günther
authors.forename: M
authors.initials: M
authors.lastname: Michel
authors.forename: R
authors.initials: R
authors.lastname: Brun
authors.forename: V
authors.initials: V
authors.lastname: Mudogo
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D003223:Congo; D006801:Humans; D007546:Isoquinolines / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology; D014345:Trypanosoma / Q000187:drug effects
chemical_list: D000962:Antimalarials; D000981:Antiprotozoal Agents; D007546:Isoquinolines; D014344:Trypanocidal Agents; C418223:ancistroealaine A; C418224:ancistroealaine B