New butenolides from two marine streptomycetes.
Chemical examination of two marine Streptomycetes has resulted in the isolation of four new butenolides, namely 4, 10-dihydroxy-10-methyl-dodec-2-en-1,4-olide (1), two diastereomeric 4,11-dihydroxy-10-methyl-dodec-2-en-1,4-olides (2/3), and 4-hydroxy-10-methyl-11-oxo-dodec-2-en-1,4-olide (4). The structures were identified by interpretation of the 2D NMR and mass spectral data.
Mukku
V J
VJ
Department of Organic Chemistry, University of Goettingen, Tammannstrasse 2, D-37077 Goettingen, Germany.
Speitling
M
M
Laatsch
H
H
Helmke
E
E
D015107:4-Butyrolactone / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002942:Circular Dichroism; D005285:Fermentation; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013172:Spores, Fungal / Q000187:drug effects; D013306:Streptomycetaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D005663:Furans; C004511:butenolide; D015107:4-Butyrolactone