Novel bioactive sulfated alkene and alkanes from the mediterranean ascidian Halocynthia papillosa.
Three sulfated alkene and alkanes-(R)-2,6-dimethylheptyl sulfate (1), 6-methylheptyl sulfate (2a), and (E)-5-octenyl sulfate (3a)-with cytotoxic activity in vitro, have been isolated from the Mediterranean ascidian Halocynthia papillosa. The structures of the new compounds 2a and 3a have been elucidated by spectroscopic analysis.
Aiello
A
A
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, via D. Montesano 49, I-80131, Napoli, Italy.
Carbonelli
S
S
Esposito
G
G
Fattorusso
E
E
Iuvone
T
T
Menna
M
M
D000473:Alkanes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006536:Heptanes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D019083:Mediterranean Region; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013431:Sulfates / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry*
C420912:2,6-dimethylheptyl sulfate; D000473:Alkanes; D000475:Alkenes; D006536:Heptanes; D013431:Sulfates