title: Myositis and interstitial lung disease associated with autoantibody to a transfer RNA-related protein Wa.
abstract: We describe 2 patients with myositis and interstitial lung disease with the autoantibody to Wa antigen, a 48-kDa transfer RNA-related protein. In contrast to the previous description of anti-Wa antibody, our patients lacked systemic sclerosis-related features, but had clinical features consistent with those associated with antibodies to aminoacyl-transfer RNA synthetases. The difference in clinical presentation between our patients and patients with systemic sclerosis may be explained by recognition of different epitopes on the Wa antigen.
authors.affiliation: Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kajihara
authors.forename: M
authors.initials: M
authors.lastname: Kuwana
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: K
authors.initials: K
authors.lastname: Yamane
authors.forename: M
authors.initials: M
authors.lastname: Kubo
authors.forename: M
authors.initials: M
authors.lastname: Hirakata
authors.forename: T
authors.initials: T
authors.lastname: Mimori
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006801:Humans; D015151:Immunoblotting; D017563:Lung Diseases, Interstitial / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000276:immunology*; D011233:Precipitin Tests; D012595:Scleroderma, Systemic / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; C069985:Wa antigen