Pulmonary function after thoracoscopic thymectomy versus median sternotomy for myasthenia gravis.
BACKGROUND
Impaired pulmonary function due to myasthenia gravis (MG) is further compromised by thymectomy, which is necessary in most cases. Thoracoscopic thymectomy (tThx) can achieve the same resection and functional improvement of MG as median sternotomy (sThx). The possible advantage of tThx in maintaining better perioperative lung function was quantified.


METHODS
In a prospective trial, 20 patients with MG were randomly allocated to undergo tThx (n = 10) by three-trocar left-sided approach or sThx (n = 10) performed as an extended procedure. Complete pulmonary function was measured at 12-hour intervals, beginning 6 hours postoperatively. Effective postoperative pain control in both groups was achieved by patient-controlled analgesia with morphine sulfate assessed by a visual analogue scale. Statistical analysis for comparison of tThx and sThx was performed using the Mann-Whitney U test.


RESULTS
Postoperative vital capacity, forced vital capacity, forced expiratory volume per second, and peak expiratory flow, measured as a percentage of the individual preoperative capacity, were significantly better with tThx compared with sThx. Immediate postoperative lung function was reduced to 35% and 65% after tThx and sThx, respectively. By the third postoperative day, recovery of pulmonary function was complete after tThx but only 55% after sThx.


CONCLUSIONS
Less pronounced impairment and faster recovery of pulmonary function after tThx characterize this new approach for thymectomy as minimally invasive. These results could make tThx the preferred surgical treatment of MG, which was improved to the same extent as after sThx.
Rückert
J C
JC
Department of Surgery, Humboldt University Medical School (Charité), Berlin, Germany. jens-c.rueckert@charite.de
Walter
M
M
Müller
J M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures; D009020:Morphine / Q000008:administration & dosage; D009157:Myasthenia Gravis / Q000503:physiopathology / Q000601:surgery*; D011446:Prospective Studies; D013249:Sternum / Q000601:surgery*; D013906:Thoracoscopy; D013934:Thymectomy / Q000379:methods*; D014797:Vital Capacity
D009020:Morphine