Variation at the serotonin transporter gene influences susceptibility to bipolar affective puerperal psychosis.
Up to half of parous females with bipolar disorder (manic depression) develop an episode of severe psychiatric disturbance, usually called puerperal psychosis, within a few days of giving birth. We report significant evidence (p<0.003) that variation at the serotonin transporter gene exerts a substantial (odds ratio=4) and important (population attributable fraction=69%) influence on susceptibility to such episodes.
Coyle
N
N
Jones
I
I
Robertson
E
E
Lendon
C
C
Craddock
N
N
D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011618:Psychotic Disorders / Q000235:genetics; D011644:Puerperal Disorders / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins; D020080:Tandem Repeat Sequences / Q000235:genetics
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D004247:DNA