Recycling to remodel: evolution of dosage-compensation complexes.
In diploid species where sex determination involves heteromorphic sex chromosomes, a mechanism has evolved to compensate for gene-dosage differences in sex-linked genes between the sexes. This regulatory mechanism, which is based on chromatin remodeling, is the function of complexes that include components themselves involved in other cellular functions or with homologs that are involved in such functions. Directing these complexes to the correct chromosome in the appropriate sex relies on pioneer or novel components as well as on the presence of sequence-dependent target sites.
Pannuti
A
A
Department of Biology and Graduate Program in Genetics and Molecular Biology, Emory University, 1510 Clifton Rd, Atlanta, Georgia 30322, USA.
Lucchesi
J C
JC
D000818:Animals; D002107:Caenorhabditis / Q000235:genetics; D002875:Chromosomes / Q000648:ultrastructure; D004247:DNA / Q000235:genetics; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics; D019143:Evolution, Molecular; D005260:Female; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D008297:Male; D022661:RNA, Untranslated; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic; D014960:X Chromosome
D015801:Helminth Proteins; D019476:Insect Proteins; D022661:RNA, Untranslated; D004247:DNA