Modulation of the Cs2CO3-promoted catalytic amination by a crown ether.
The catalytic addition of 18-Crown-6 in some Cs2CO3-promoted amination of triflates and bromides was beneficial to improve sluggish reaction with suppression of the unwanted side products. The protocol was useful for the preparation of chlorinated aryl piperazines from phenol derivatives.
Torisawa
Y
Y
Process Research Laboratory, Second Tokushima Factory, Otsuka Pharmaceutical Co., Ltd, Japan. torisawa@fact.otsuka.co.jp
Nishi
T
T
Minamikawa
J
J
D000586:Amination; D002384:Catalysis; D002586:Cesium / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000737:chemistry*; D015394:Molecular Structure
D004988:Ethers, Cyclic; D002586:Cesium