The treatment of bleeding in hemophilic patients with inhibitors with recombinant factor VIIa.
Recombinant factor VIIa (rFVIIa) has proven efficacy in the treatment of patients with alloantibodies and autoantibodies to factors VIII and IX. More than 80% of over 2,000 reported bleeding episodes treated with rFVIIa have been controlled in a variety of clinical circumstances. Its theoretical lack of activation of the coagulation system prompted many clinicians to undertake elective surgical procedures using rFVIIa in addition to on-demand treatment of minor bleeding episodes. Hemostatic efficacy has been good for most of these surgical procedures, without serious adverse events. rFVIIa is considered a useful, safe, and effective treatment for bleeding in patients with anti-factor VIII (FVIII) and anti-factor IX (FIX) inhibitors. However, the optimal dose for various clinical situations has yet to be established and requires further investigation. Laboratory monitoring of treatment using plasma FVIIa measurements should be better standardized. Despite the relatively high cost of this new drug, rFVIIa represents a major therapeutic advance in the treatment of hemophilic patients with inhibitors.
Negrier
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Centre Régional de Traitement de l'Hémophilie, Laboratoire d'Hémostase, Hôpital Edouard Heriot, Lyon, France. negrier@laennec.univ-lyon1.fr
Hay
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D001323:Autoantibodies / Q000276:immunology; D005164:Factor IX / Q000276:immunology; D005167:Factor VII / Q000627:therapeutic use*; D005169:Factor VIII / Q000276:immunology; D015942:Factor VIIa; D006467:Hemophilia A / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D006470:Hemorrhage / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D011994:Recombinant Proteins / Q000627:therapeutic use*
D001323:Autoantibodies; D007519:Isoantigens; D011994:Recombinant Proteins; D005167:Factor VII; D005169:Factor VIII; D005164:Factor IX; C103587:recombinant FVIIa; D015942:Factor VIIa