A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.
Leukocyte chemoattractants are involved in the inflammatory response act via G protein-coupled receptors. We report the cloning of a novel human gene encoding the putative orphan receptor, C5L2, belonging to a subfamily of C3a, C5a and formyl Met-Leu-Ph receptors that are related to the chemokine receptor family. C5L2 transcript levels were abundant in granulocytes and immature dendritic cells but not in mature dendritic cells. We speculate that this receptor may regulate the activation of immature dendritic cells and play a role in the chemoattraction of leukocytes to inflammatory regions.
Ohno
M
M
The Second Research Department, Central Technology Laboratory, Asahi Chemical Industry Co., Ltd., Samejima 2-1, Fuji-shi, Shizuoka 416-8501, Japan. ohno.md@om.asahi-kasei.co.jp
Hirata
T
T
Enomoto
M
M
Araki
T
T
Ishimaru
H
H
Takahashi
T A
TA
D000595:Amino Acid Sequence; D000906:Antibodies; D002454:Cell Differentiation; D002460:Cell Line; D003001:Cloning, Molecular; D003713:Dendritic Cells / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism*; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D006098:Granulocytes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D044087:Receptor, Anaphylatoxin C5a; D019707:Receptors, Chemokine / Q000032:analysis* / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment; D014162:Transfection
D000906:Antibodies; C417003:C5aR2 protein, human; D012333:RNA, Messenger; D044087:Receptor, Anaphylatoxin C5a; D019707:Receptors, Chemokine