title: [Genome methylation and its role in functioning of the eukaryotic organism].
abstract: Methylation is a modification that changes the structure and functional status of DNA. Hence it is interesting to study the effect of methylation on basic processes occurring in living cells. In this review, the role of DNA methylation in recombination, replication, transcription regulation, imprinting, tumorigenesis, and tumor progression is considered.
authors.affiliation: Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Prokhorchuk
authors.forename: A S
authors.initials: AS
authors.lastname: Ruzov
mesh_terms: D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D018899:CpG Islands; D004247:DNA / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015254:DNA Modification Methylases / Q000378:metabolism; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism / Q000502:physiology; D016678:Genome; D018392:Genomic Imprinting; D006801:Humans; D008745:Methylation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011995:Recombination, Genetic; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D004247:DNA; D015254:DNA Modification Methylases