Synthesis of cis and trans isomers of an isoxazoline ring-hydroxylated metabolite of roxifiban, a platelet glycoprotein IIb/IIIa receptor antagonist.
Batt
D G
DG
Department of Chemical and Physical Sciences, The DuPont Pharmaceuticals Company, Experimental Station, Wilmington, Delaware 19880-0500, USA. douglas.g.batt@dupontpharma.com
Houghton
G C
GC
Daneker
W F
WF
Jadhav
P K
PK
D000578:Amidines / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D006801:Humans; D007555:Isoxazoles / Q000378:metabolism*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D051381:Rats
D000578:Amidines; D007555:Isoxazoles; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; C118235:roxifiban