Circadian rhythm of serum total homocysteine in men.
Serum homocysteine levels were examined in a 24-hour study of 7 healthy and 5 diabetic men, revealing a statistically significant circadian rhythm (p = 0.030), normal concentrations of 11.83 +/- 1.2 vs 12.99 +/- 1.2 micromol/L, with peak values occurring during the evening (10:37 P.M.) and lowest levels occurring during the morning. These findings imply that increased atherosclerotic risk in insulin-resistant diabetics during morning hours does not appear to be explained by differences in homocysteine levels in the normal population.
Bremner
W F
WF
MacNeal Cardiology Group, Berwyn, Illinois 60402, USA.
Holmes
E W
EW
Kanabrocki
E L
EL
Hermida
R C
RC
Ayala
D
D
Garbincius
J
J
Third
J L
JL
Ryan
M D
MD
Johnson
M
M
Foley
S
S
Shirazi
P
P
Nemchausky
B A
BA
Scheving
L E
LE
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000209:etiology; D016022:Case-Control Studies; D002940:Circadian Rhythm; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000145:classification / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors
D006710:Homocysteine