title: Analysis of the arterial blood pressure waveform during left ventricular nonpulsatile assistance in animal models.
abstract: When the rotary blood pump is used as a left ventricular assist device (LVAD), the arterial blood pressure waveform changes with the LVAD condition. Based on evidence from an in vitro study, the change of the arterial blood pressure waveform during left ventricular assistance was evaluated using animal models. After the left pleural cavity was opened through the fifth intercostal space under general anesthesia, a rotary blood pump was implanted as an LVAD into 6 healthy calves. The direct left carotid arterial blood pressure waveform was measured and recorded by an oscilloscope. The Fast Fourier Transform technique was utilized to analyze the arterial blood pressure waveform and calculate the pulsatility index (PI) and the pulse power index (PPI). Similar to the in vitro study, the PI and PPI decreased exponentially with the increase of the LVAD assist ratio. By using this analysis methodology, a physiologically effective ventricular assistance might be achieved.
authors.affiliation: Baylor College of Medicine, Department of Surgery, Houston, Texas 77030, USA. kawahito@bcm.tmc.edu
authors.forename: S
authors.initials: S
authors.lastname: Kawahito
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Nonaka
authors.forename: J
authors.initials: J
authors.lastname: Linneweber
authors.forename: S
authors.initials: S
authors.lastname: Schulte-Eistrup
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Mikami
authors.forename: J
authors.initials: J
authors.lastname: Glueck
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D001795:Blood Pressure Determination; D002417:Cattle; D005260:Female; D006353:Heart-Assist Devices; D011673:Pulsatile Flow; D012044:Regression Analysis; D012815:Signal Processing, Computer-Assisted; D016277:Ventricular Function, Left