C-reactive protein (CRP) measurement in canine serum following experimentally-induced acute gastric mucosal injury.
To establish the diagnostic significance of canine C-reactive protein (CRP) in gastrointestinal disorders, the serum canine CRP concentration was measured in dogs with experimentally-induced acute gastric mucosal injury. Gastric injury was induced in one male and one female beagle by a single dose oral administration of acetylsalicylic acid (200 mg/kg body weight) or indomethacin (60 mg/kg body weight), or sodium chloride (1,000 mg/kg body weight). CRP was measured prior to dose, and 1, 3, 7, and 14 days after the administration of the drugs, together with the total leucocyte counts and serum iron. Changes in the serum CRP in dogs with gastric injury were similar for the three test compounds, and reflected by the endoscopic findings. CRP values increased from 87 to 390 mg/l within 1 to 3 days after the compound administration but returned nearly to the predose levels within 14 days. Endoscopy revealed haemorrhagic erosion of the gastric mucosa in all dogs one day after dosing, with no evidence of the erosions observed after 7 days in many of the dogs. Changes of the total leucocyte and serum iron also occurred following gastric injury, but these changes were not as marked as those observed for CRP. The results of this study suggest that serum CRP level may be a useful indicator of a gastrointestinal mucosal injury in dogs.
Otabe
K
K
Safety Assessment Laboratory, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan.
Ito
T
T
Sugimoto
T
T
Yamamoto
S
S
D000818:Animals; D001241:Aspirin / Q000633:toxicity; D002097:C-Reactive Protein / Q000032:analysis*; D004285:Dogs / Q000097:blood*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D007213:Indomethacin / Q000633:toxicity; D007501:Iron / Q000097:blood; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D012965:Sodium Chloride / Q000633:toxicity
D012965:Sodium Chloride; D002097:C-Reactive Protein; D007501:Iron; D001241:Aspirin; D007213:Indomethacin