title: Cytogenetic and ultrastructural study of a pineocytoma case report.
abstract: The authors report a case of pineocytoma in a 44-year-old woman suffering from headache, vomiting and Parinaud syndrome. At histopathological examination the neoplasm showed a ill-defined lobulate pattern with some small pineocytomatous rosettes. The electron-microscopy revealed cells of moderate size and oval nuclei with smooth nuclear envelopes; well-developed organelles were found in the, abundant cytoplasm. The chromosome analysis revealed this kariotype: 58-59, XXX, -4, -5, -13, - 14, -15, + 19. This is the first report of a pineocytoma with ultrastructural and cytogenetic study; it confirms the literature findings of the electron-microscopy, whereas there is partial accordance with the previous cytogenetic studies.
authors.affiliation: Neurosurgical Department, Varese Regional Hospital and Macchi Foundation, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Dario
authors.forename: M
authors.initials: M
authors.lastname: Cerati
authors.forename: M
authors.initials: M
authors.lastname: Taborelli
authors.forename: G
authors.initials: G
authors.lastname: Finzi
authors.forename: M
authors.initials: M
authors.lastname: Pozzi
authors.forename: A
authors.initials: A
authors.lastname: Dorizzi
mesh_terms: D000328:Adult; D000782:Aneuploidy; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000235:genetics / Q000601:surgery / Q000648:ultrastructure*; D002557:Cerebrospinal Fluid Shunts; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D005260:Female; D006801:Humans; D007621:Karyotyping; D009363:Neoplasm Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D010870:Pineal Gland / Q000601:surgery / Q000648:ultrastructure*; D010871:Pinealoma / Q000737:chemistry / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure*; D016708:Synaptophysin / Q000032:analysis; D014314:Trisomy
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase