title: Effect of systemic penicillin on pain in untreated irreversible pulpitis.
abstract: OBJECTIVE
  The purpose of this prospective, randomized, double-blind study was to determine the effect of penicillin on pain in untreated teeth diagnosed with irreversible pulpitis.
  
  
  METHODS
  Forty emergency patients participated, and each had a clinical diagnosis of an irreversible pulpitis. Patients randomly received a 7-day oral dose (28 capsules, 500 mg each, to be taken every 6 hours) of either penicillin or a placebo control in a double-blind manner. No endodontic treatment was performed. Each patient also received ibuprofen; acetaminophen with codeine (30 mg); and a 7-day diary to record pain, percussion pain, and number and type of pain medication taken.
  
  
  RESULTS
  The administration of penicillin did not significantly (P >.05) reduce pain, percussion pain, or the number of analgesic medications taken by patients with untreated irreversible pulpitis. The majority of patients with untreated irreversible pulpitis had significant pain and required analgesics to manage this pain.
  
  
  CONCLUSIONS
  Penicillin should not be prescribed for untreated irreversible pulpitis because penicillin is ineffective for pain relief.
authors.affiliation: The Ohio State University, Columbus 43218-2357, USA.
authors.forename: D
authors.initials: D
authors.lastname: Nagle
authors.forename: A
authors.initials: A
authors.lastname: Reader
authors.forename: M
authors.initials: M
authors.lastname: Beck
authors.forename: J
authors.initials: J
authors.lastname: Weaver
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010404:Penicillin V / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D011446:Prospective Studies; D011671:Pulpitis / Q000150:complications / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D014098:Toothache / Q000188:drug therapy* / Q000209:etiology; D017211:Treatment Failure
chemical_list: D010406:Penicillins; D010404:Penicillin V