title: Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides.
abstract: Nine bis-acridine derivatives have been synthesized in search of structures with antiviral properties. Synthesis of target compounds was provided by a standard peptide-like coupling procedure using aliphatic diamines and protected amino acids following protective group removing and acridinylation by means of 9-methoxyacridine. Two out of nine compounds tested demonstrate high protective activity of Vero cells against HSV infection. Antiviral activity was observed only for compounds containing a pentamethylene fragment as a linker. The alanyl-containing derivative was less active than those containing valyl- and phenylalanyl. Most of synthesized compounds were less toxic than N,N'-bis-(acridinyl) hexamethylenediamine.
authors.affiliation: A. V. Bogatsky Physico-Chemical Institute, National Academy of Sciences of Ukraine, Odessa, Ukraine.
authors.forename: S A
authors.initials: SA
authors.lastname: Lyakhov
authors.forename: Y I
authors.initials: YI
authors.lastname: Suveyzdis
authors.forename: L A
authors.initials: LA
authors.lastname: Litvinova
authors.forename: S A
authors.initials: SA
authors.lastname: Andronati
authors.forename: S L
authors.initials: SL
authors.lastname: Rybalko
authors.forename: S T
authors.initials: ST
authors.lastname: Dyadyun
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002522:Chlorocebus aethiops; D007364:Intercalating Agents / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D018139:Simplexvirus / Q000187:drug effects; D014709:Vero Cells
chemical_list: D000166:Acridines; D000998:Antiviral Agents; D007364:Intercalating Agents