title: Synthesis of galactosyl and lactosyl derivatives as potential anti-metastasis compounds.
abstract: Based on the known anti-metastasis activities of lactosides and galactosides, a galactosyl and a lactosyl trimannoside were prepared via the conventional Koenigs-Knorr and trichloroacetimidate methods, respectively. Through typical deblocking procedures, a tetrasaccharide alpha-D-Galp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 and a pentasaccharide beta-D-Galp-(1 --> 4)-beta-D-Glcp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 were obtained.
authors.affiliation: Department of Bioorganic Chemistry, School of Pharmaceutical Sciences, Beijing Medical University, PR China.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: M S
authors.initials: MS
authors.lastname: Cai
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D005697:Galactosides / Q000138:chemical synthesis*; D006027:Glycosides / Q000138:chemical synthesis*; D008362:Mannosides / Q000737:chemistry; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D005697:Galactosides; D006027:Glycosides; D008362:Mannosides; D009844:Oligosaccharides; C008245:lactosides