[Effect of immunization to cholecystokinin fragment (30-33) on the behavior of albino rats].
Active immunisation of albino rats by the BSA-conjugated CCK-4 induced formation of antibodies to the CCK-4 and some long-term changes of the rat behaviour. These changes were contrary to anxiogenic effect of the CCK-4 and demonstrated an anxiolytic effect of the immunisation. The data obtained suggest a possibility of an immunocorrection of pathological anxiety and fear by an inverse immunoregulation.
Danilova
R A
RA
Moscow State University, Vorobyevy Gory.
Rud'ko
O I
OI
Korotkova
T M
TM
Obukhova
M F
MF
Ashmarin
I P
IP
D000428:Alcohol Drinking; D000818:Animals; D000906:Antibodies / Q000097:blood / Q000737:chemistry / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D004797:Enzyme-Linked Immunosorbent Assay; D005106:Exploratory Behavior / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D017288:Pain Threshold; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000737:chemistry; D013758:Tetragastrin / Q000276:immunology* / Q000494:pharmacology; D014611:Vaccination
D000906:Antibodies; D012709:Serum Albumin; D013758:Tetragastrin