Hemodynamic effects of periodic G(z) acceleration in meconium aspiration in pigs.
The hemodynamic effects of periodic acceleration (pG(z)), induced in the spinal axis with noninvasive motion ventilation (NIMV), were studied in a piglet model of pulmonary hypertension associated with meconium aspiration. Animals (n = 12) were anesthetized, paralyzed, intubated, and supported by conventional mechanical ventilation (CMV). Thirty minutes after tracheal instillation of meconium solution (6 ml/kg), either CMV (n = 6) was continued or NIMV (n = 6) was initiated. Changes in systemic and pulmonary hemodynamics and arterial blood gases were tracked for 2 h after aspiration. Thermodilution, cardiac output, and heart rate were not significantly different after meconium aspiration in the pG(z) group relative to the CMV controls. Aortic pressure and systemic vascular resistance were significantly lower (approximately 30%) after meconium aspiration in NIMV animals relative to CMV animals. Pulmonary arterial pressure and pulmonary vascular resistance were also significantly lower, by 100%, after aspiration of meconium in the NIMV animals compared with the CMV controls. Meconium aspiration significantly decreased total respiratory compliance by approximately 50% and increased total respiratory resistance by approximately 100% in both CMV and NIMV animals, but such alterations did not differ between the two groups. Both CMV and NIMV satisfactorily supported ventilation in these paralyzed animals. In conclusion, NIMV through pG(z) in the spinal axis decreased systemic and pulmonary vascular resistance in piglets after meconium aspiration.
Adams
J A
JA
Division of Neonatology, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA. tony@msmc.com
Mangino
M J
MJ
Bassuk
J
J
Sackner
M A
MA
D000054:Acceleration; D000403:Airway Resistance; D000818:Animals; D000831:Animals, Newborn; D001011:Aorta / Q000503:physiopathology; D001794:Blood Pressure; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology*; D007231:Infant, Newborn; D008170:Lung Compliance; D008471:Meconium Aspiration Syndrome / Q000150:complications / Q000503:physiopathology*; D010507:Periodicity; D011652:Pulmonary Circulation; D012121:Respiration, Artificial; D012138:Respiratory Therapy / Q000379:methods*; D013552:Swine