Decline in antibiotic enzyme activity of neutrophils is a prognostic factor for infections in patients with myelodysplastic syndrome.
We used flow cytometry to measure the activities of cathepsin G and elastase. The activity of elastase in neutrophils from patients with myelodysplastic syndrome (MDS) was significantly lower than that in neutrophils from the control group (P<.001). Patients with low elastase activity were significantly susceptible to infection (P<. 05). Our study suggests that analyzing antibacterial enzymes is useful in evaluating the prognosis of patients with MDS.
Ito
Y
Y
First Department of Internal Medicine, Tokyo Medical University, Japan. yito@tokyo-med.ac.jp
Kawanishi
Y
Y
Shoji
N
N
Ohyashiki
K
K
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D056649:Cathepsin G; D002403:Cathepsins / Q000378:metabolism; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000201:enzymology* / Q000473:pathology; D009504:Neutrophils / Q000166:cytology / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000378:metabolism; D011379:Prognosis; D012697:Serine Endopeptidases; D016019:Survival Analysis
D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D010196:Pancreatic Elastase