title: [Serum concentration of amantadine in the treatment of children with influenza type A infection].
abstract: Fifteen children with influenza type A (H3N2) virus infection (mean age, 38 months) were treated with amantadine. Amantadine was prescribed as 5 mg/kg/day and the serum concentration was measured in 5-7 days. As a result, the mean serum concentration of amantadine was 164.6 +/- 92.5 ng/ml (range, 67.4-446.9 ng/ml). Adverse reactions were not associated to them. Amantadine therapy against influenza type A infection is probably safe in children because of the low serum concentration shown in this study.
authors.affiliation: Department of Pediatrics, Isehara Kyodo Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: O
authors.initials: O
authors.lastname: Komiyama
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: N
authors.initials: N
authors.lastname: Sugaya
mesh_terms: D000547:Amantadine / Q000008:administration & dosage / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009980:Influenza A virus; D007251:Influenza, Human / Q000188:drug therapy*
chemical_list: D000547:Amantadine