Pregnancy and progression to AIDS: results of the French prospective cohorts. SEROGEST and SEROCO Study Groups.
OBJECTIVE
To investigate whether pregnancy accelerates HIV-1 disease progression.


METHODS
In two large French SEROCO and SEROGEST prospective cohorts of HIV infected patients, the progression to AIDS in 365 women with a known date of HIV-1 seroconversion was examined by comparing those who delivered after HIV infection (n = 241) with those who did not become pregnant while HIV-infected (n = 124).


RESULTS
The crude relative risk of developing AIDS associated with pregnancy was 0.7 [95% confidence interval (CI), 0.4-1.2]. Adjustment for age at seroconversion, the CD4+ cell percentage at entry, and the method used to date seroconversion did not modify the results (adjusted relative risk, 0.7; 95% CI 0.4-1.2).


CONCLUSIONS
No deleterious effect of pregnancy on progression from seroconversion to AIDS was found. This result has important implications for the counselling of HIV-infected women of child-bearing age.
Saada
M
M
Service d'Epidémiologie and INSERM U292, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
Le Chenadec
J
J
Berrebi
A
A
Bongain
A
A
Delfraissy
J F
JF
Mayaux
M J
MJ
Meyer
L
L
D000163:Acquired Immunodeficiency Syndrome; D000328:Adult; D003376:Counseling; D018450:Disease Progression; D005260:Female; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011446:Prospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D013997:Time Factors