title: Effect of roxarsone inclusion in the diet on the performance and hepatic lipid metabolism of laying Tsaiya duck.
abstract: 1. The aim of this study was to examine the effects of roxarsone (3-nitro-4-hydroxyphenylarsonic acid) inclusion in the diet on the performance, liver function and lipid metabolism in the liver of laying Brown Tsaiya ducks. 2. Sixty 36-week-old laying ducks were selected and allocated at random into 4 dietary treatments with 3 replications for each treatment. Feeding was for 7 weeks with 3 weeks of experimental diets followed by a 4 week withdrawal period. The experimental diets were supplemented with 0, 50, 100 and 300 mg/kg roxarsone, respectively 3. Dietary inclusion of 50 or 100 mg/kg roxarsone did not significantly promote performance. Inclusion of 300 mg/kg significantly depressed (P<0.05) performance, liver weight and content, serum triacylglycerol (TG), serum nonesterified fatty acid (NEFA) and increased (P<0.05) cholesterol, creatine kinase (CK) and aspartate aminotransferase (AST) in the serum at the end of 3 weeks on the experimental diet. 4. Laying characteristics returned to normal 4 weeks after withdrawal of roxarsone. The liver weight, fat and TG in the liver and serum concentrations of TG, NEFA, high density lipoprotein (HDL) and AST increased significantly (P<0.05), while the level of very low density lipoprotein (VLDL) decreased (P<0.05) at the end of the withdrawal period. More prominent vacuolised hepatic fatty cells were observed in laying ducks treated with 300 mg/kg of roxarsone.
authors.affiliation: National Chia-Yi University, Taiwan.
authors.forename: K L
authors.initials: KL
authors.lastname: Chen
authors.forename: C P
authors.initials: CP
authors.lastname: Wu
authors.forename: P W
authors.initials: PW
authors.lastname: Chiou
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003049:Coccidiostats / Q000494:pharmacology*; D003402:Creatine Kinase / Q000097:blood; D004372:Ducks / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D004435:Eating / Q000502:physiology; D004531:Eggs; D005227:Fatty Acids / Q000097:blood; D005234:Fatty Liver / Q000473:pathology; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood; D016014:Linear Models; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000737:chemistry / Q000473:pathology / Q000502:physiology*; D010058:Oviposition / Q000502:physiology; D011897:Random Allocation; D012406:Roxarsone / Q000494:pharmacology*; D012709:Serum Albumin / Q000032:analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D003049:Coccidiostats; D005227:Fatty Acids; D008074:Lipoproteins; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D012406:Roxarsone