Nonhepatosplenic gamma delta T-cell lymphoma with initial testicular compromise.
We report here a case of nonhepatosplenic gammadelta T-cell lymphoma with undescribed initial localization in testis, without hepatosplenomegaly or adenopathies, and subsequent development in the maxillary sinus. The maxillar mass biopsy revealed a T-cell infiltration, and its immunologic characterization by flow cytometry showed a gammadelta T-cell phenotype (CD45+, CD3+, CD2+, TCR gammadelta+), without expression of CD7, CD5, CD1a, TdT, CD4, CD8, TCR alphabeta, or NK antigens (CD16, CD56, and CD57). Clonal gamma-chain gene rearrangement by polymerase chain reaction (PCR) was detected in testicular and maxillar biopsies. Epstein-Barr virus type 1 (EBV) sequences were detected by molecular biology in the biopsy material, suggesting that this oncogenic virus may play a role in the genesis of the clonal expansion of gammadelta T-cells. The patient was initially treated with standard chemotherapeutic protocols, with poor response and aggressive course.
Scolnik
M P
MP
Instituto de Investigaciones Hematológicas Mariano R. Castex, Academia Nacional de Medicina de Buenos Aires, Argentina. mscolnik@interlink.com.ar
Burgos
R A
RA
Paz
A
A
Weinreiter
M
M
del Carmen Ardaiz
M
M
Bare
P
P
Hanza
M C
MC
de Dios Soler
M A
MA
Narbaitz
M I
MI
Palacios
M F
MF
Sasot
A
A
Huberman
A
A
de Bracco
M M
MM
D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000473:pathology; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D013160:Splenic Neoplasms / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology*
D016692:Receptors, Antigen, T-Cell, gamma-delta