Inhibitory effects of 2'-hydroxychalcones on rat lens aldose reductase and rat platelet aggregation.
Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhibited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC50=0.10 and 0.06 mg/ml, respectively) and collagen (IC50=44 and 16 microg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.
Lim
S S
SS
Natural Products Research Institute, Seoul National University, Jongro-gu, Korea.
Jung
S H
SH
Ji
J
J
Shin
K H
KH
Keum
S R
SR
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004791:Enzyme Inhibitors; D010975:Platelet Aggregation Inhibitors; D002599:Chalcone; D000449:Aldehyde Reductase