title: Necrotizing fasciitis and toxic shock-like syndrome caused by group B streptococcus.
abstract: A recent increase in reports of necrotizing fasciitis resulting from group B streptococcus has alerted physicians to a possible concomitant increase of toxic shock-like syndrome. We report the second case of group B streptococcus causing necrotizing fasciitis and toxic shock-like syndrome. A black woman, aged 52 years, with newly diagnosed diabetes mellitus had necrotizing fasciitis type II of the left groin. Hypotension, elevated bilirubin and liver enzymes, and adult respiratory distress syndrome rapidly developed. Because group B streptococcus was isolated from a normally sterile site, the patient's condition met the criteria for toxic shock-like syndrome. Extensive surgical debridement, hyperbaric oxygen therapy, and intravenous antibiotic therapy (including clindamycin) were required for complete recovery. The antitoxin effects of hyperbaric oxygen therapy and clindamycin should be further investigated for the treatment of such patients.
authors.affiliation: Department of Internal Medicine Education, Memorial Health University Medical Center, Savannah, GA 31404, USA.
authors.forename: B
authors.initials: B
authors.lastname: Holmström
authors.forename: E W
authors.initials: EW
authors.lastname: Grimsley
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003646:Debridement; D048909:Diabetes Complications; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D019115:Fasciitis, Necrotizing / Q000150:complications / Q000382:microbiology* / Q000628:therapy; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D006931:Hyperbaric Oxygenation; D008875:Middle Aged; D012772:Shock, Septic / Q000150:complications / Q000382:microbiology* / Q000628:therapy; D013292:Streptococcus agalactiae / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D002981:Clindamycin