title: Analysis of outcomes for high-risk breast cancer based on interval from surgery to postmastectomy radiation therapy.
abstract: OBJECTIVE
  The success of adjuvant chemotherapy has prolonged the interval between surgery and postmastectomy radiation therapy for high-risk breast cancer patients. The purpose of this study is to determine whether a delay in radiation therapy after mastectomy results in an increased risk of local-regional recurrence of breast cancer.
  
  
  METHODS
  A retrospective review was performed of the University of Pennsylvania database of 221 patients with high-risk breast cancer treated with postmastectomy radiation therapy between 1977 and 1992. The surgery to postmastectomy radiation therapy time interval was 2 months or less in 82 patients (37%), 2.1 to 6 months in 50 patients (23%), and greater than 6 months in 89 patients (40%). Adjuvant chemotherapy was utilized in 151 patients (68%). The median follow-up was 4.3 years after postmastectomy radiation therapy.
  
  
  RESULTS
  Because the three groups showed significant differences for a number of prognostic factors, outcomes are reported in terms of local-regional recurrence only and not survival. The actuarial rate of local-regional recurrence at 8 years was 13% for patients with a surgery to radiation therapy interval of 2 months or less, 4% for those with an interval of 2.1 to 6 months, and 12% for those with an interval of greater than 6 months. A similar analysis performed for 4 months or less versus greater than 4 months between surgery and postmastectomy radiation therapy showed no difference in local-regional recurrence (11% versus 10%, respectively).
  
  
  CONCLUSIONS
  A delay in the institution of postmastectomy radiation therapy in favor of the prolongation of chemotherapy for high-risk breast cancer patients does not adversely affect outcome for local-regional recurrence at 8 years.
authors.affiliation: Department of Radiation Oncology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Metz
authors.forename: D J
authors.initials: DJ
authors.lastname: Schultz
authors.forename: K
authors.initials: K
authors.lastname: Fox
authors.forename: A
authors.initials: A
authors.lastname: Mathews
authors.forename: J
authors.initials: J
authors.lastname: Glick
authors.forename: L J
authors.initials: LJ
authors.lastname: Solin
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D008408:Mastectomy; D008593:Menopause; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome