title: Activation of human CIC-2 Cl- channels: implications for cystic fibrosis.
abstract: 1. The CIC-2 Cl- channels are present in the adult human lung epithelia and, therefore, are a potential target for therapy in cystic fibrosis. 2. Activators of CIC-2 Cl- channels that may have physiological relevance include activation by reduced external pH, protein kinase A and arachidonic acid. 3. Activators of CIC-2 Cl- channels that have therapeutic potential include amidation and omeprazole and, perhaps, effectors of arachidonic acid metabolism.
authors.affiliation: Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Ohio 45267-0576, USA. john.cuppoletti@uc.edu
authors.forename: J
authors.initials: J
authors.lastname: Cuppoletti
authors.forename: K P
authors.initials: KP
authors.lastname: Tewari
authors.forename: A M
authors.initials: AM
authors.lastname: Sherry
authors.forename: D H
authors.initials: DH
authors.lastname: Malinowska
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001711:Biotransformation; D065101:Chloride Channel Agonists; D018118:Chloride Channels / Q000737:chemistry / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D065101:Chloride Channel Agonists; D018118:Chloride Channels