Preparation and characterization of acrylic hydrogels neutralized by basic amino acids.
Basic amino acids were used as neutralizers in the gellation of Eudispert as an acrylic hydrogel. Arginine and lysine successfully neutralized Eudispert, as did sodium hydroxide, and formed hydrogels. A gentle rise of pH was observed as the dosage of the base increased when arginine and lysine were used, in contrast to the sharp rise of pH observed when sodium hydroxide was used. The rank of viscosity of the prepared hydrogels was as follows: lysine > arginine > NaOH. The release rate of model drugs (salicylic acid, theophylline, and bovine insulin) from the prepared hydrogels ranked as follows: NaOH>lysine>arginine, the sustained-release profile being observed with arginine. The rate of diffusion of the model drug from the hydrogel was inversely proportional to the molecular weight of the cationized neutralizer used. It is concluded that the strategy of neutralization of acidic polymers by basic amino acids has advantage with the respect to both the sustained-release characteristics of the gel and the biocompatibility of the basic amino acids themselves.
Uchida
T
T
School of Pharmaceutical Sciences, Mukogawa Women 's University Nishinomiya, Japan.
Toida
Y
Y
Miyanaga
Y
Y
Machida
K
K
Wada
K
K
Ohki
T
T
Matsuyama
K
K
D000596:Amino Acids / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D007328:Insulin / Q000008:administration & dosage / Q000737:chemistry; D007700:Kinetics; D008970:Molecular Weight; D011109:Polymethacrylic Acids / Q000737:chemistry*; D020156:Salicylic Acid / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry; D014783:Viscosity
D000596:Amino Acids; D020100:Hydrogels; D007328:Insulin; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D013806:Theophylline; D020156:Salicylic Acid