Electrochemiluminescent detection of chlorpromazine by selective preconcentration at a lauric acid-modified carbon paste electrode using tris(2,2'-bipyridine)ruthenium(II).
A new detection scheme for the determination of adsorbable coreactants of Ru(bpy)3(2+) electrochemiluminescent reaction is presented. It is based on selective preconcentration of coreactant onto an electrode, followed by Ru(bpy)3(2+) electrochemiluminescent detection. The coreactant employed is chlorpromazine. It was sensitively detected after 5-min preconcentration onto a lauric acid-modified carbon paste electrode. The linear concentration range was found to occur from 1 x 10(-8) to 3 x 10(-6) mol L-1 with a detection limit of 3.1 x 10(-9) mol L-1. The total analysis time is less than 10 min. As a result of selective preconcentration and medium exchange, such remarkable selectivity is achieved that reproducible quantitation of chlorpromazine in urine is possible.
Xu
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G
Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, P.R.C.
Dong
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D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives; D014150:Antipsychotic Agents / Q000032:analysis*; D002138:Calibration; D002746:Chlorpromazine / Q000032:analysis*; D056831:Coordination Complexes; D004563:Electrochemistry; D004566:Electrodes; D007202:Indicators and Reagents; D007850:Lauric Acids; D008163:Luminescent Measurements; D017975:Ruthenium Compounds
D015082:2,2'-Dipyridyl; D014150:Antipsychotic Agents; D002746:Chlorpromazine; D056831:Coordination Complexes; D007202:Indicators and Reagents; D007850:Lauric Acids; C547232:tris(2,2-bipyridine)-ruthenium(II); D017975:Ruthenium Compounds