NMR assignments for glucosylated and galactosylated N-acetylhexosaminitols: oligosaccharide alditols related to O-linked glycans from the protozoan parasite Trypanosoma cruzi.
We report full 1H and 13C NMR assignments for 13 gluco- or galacto-pyranosylated derivatives of GlcNAc-ol, GalNAc-ol or ManNAc-ol, many of which have been prepared by enzymatic methods. These spectra are reference data to aid the structural analysis by NMR spectroscopy of glycosylated alditols derived from the mucin of the protozoan parasite Trypanosoma cruzi. A series of structural reporter groups for the derivatives from this unusual series of O-glycans are described.
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Laboratory for Molecular Structure, National Institute for Biological Standards and Control, South Mimms, Herts, UK. cjones@nibsc.ac.uk
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D000818:Animals; D002240:Carbohydrate Sequence; D005690:Galactose / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009077:Mucins / Q000737:chemistry; D009844:Oligosaccharides / Q000737:chemistry*; D013402:Sugar Alcohols / Q000737:chemistry*; D014349:Trypanosoma cruzi / Q000737:chemistry*
D009077:Mucins; D009844:Oligosaccharides; D013402:Sugar Alcohols; D006026:Glycoside Hydrolases; D005690:Galactose