Metabolic control: a new solution to an old problem.
The phenomenon whereby the presence of oxygen regulates the rate of glucose metabolism was first described by Louis Pasteur. A novel mechanism has now been discovered, involving the AMP-activated protein kinase cascade, that can account for the Pasteur effect in ischaemic heart muscle.
Hardie
D G
DG
Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, Scotland, UK. d.g.hardie@dundee.ac.uk
D055372:AMP-Activated Protein Kinases; D000818:Animals; D006019:Glycolysis; D006706:Homeostasis; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D017202:Myocardial Ischemia / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
D009097:Multienzyme Complexes; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases