From the ECM to the cytoskeleton and back: how integrins orchestrate T cell action.
T lymphocytes constitute a highly dynamic tissue type. During the course of their lives, they travel through a variety of physiological environments and experience a multitude of interactions with extracellular matrix components and other cells. In order to do this, they must receive many environmental cues, and translate these signals into the appropriate biological actions. Particularly dramatic are the cytoskeletal shape changes a T cell must undergo during the processes of leaving the bloodstream, migrating through tissues, and encountering antigen. In this review, we highlight the role of integrins in providing a link between the extracellular environment and cytoskeletal regulation and how these receptors help to orchestrate T cell migration and antigen recognition.
Epler
J A
JA
Department of Laboratory Medicine and Pathology, Center for Immunology, Cancer Center, University of Minnesota Medical School, Minneapolis 55455, USA.
Liu
R
R
Shimizu
Y
Y
D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology; D002448:Cell Adhesion; D002465:Cell Movement; D018925:Chemokines / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology*; D007376:Interleukin-2 / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*
D018925:Chemokines; D016023:Integrins; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell