Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and men.
Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.
Fugger
L
L
Department of Clinical Immunology, Aarhus University Hospital, Skejby Sygehus, Denmark. fugger@inet.uni2.dk
Svejgaard
A
A
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004195:Disease Models, Animal; D015804:HLA-DR4 Antigen / Q000235:genetics / Q000276:immunology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic
D015804:HLA-DR4 Antigen