title: Incidence of imipenem hypersensitivity reactions in febrile neutropenic bone marrow transplant patients with a history of penicillin allergy.
abstract: The purpose of this retrospective study was to assess cross-hypersensitivity between imipenem/cilastatin and penicillin in patients with reported penicillin allergies. Medical records of febrile neutropenic, penicillin-allergic bone marrow transplant recipients who received imipenem/cilastatin treatment were retrospectively reviewed. The findings of this study indicate the incidence of cross-reactivity between imipenem/cilastatin and penicillin among patients with a history of penicillin allergy may be lower than previously reported.
authors.affiliation: College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA. mcconnellscotta@uams.edu
authors.forename: S A
authors.initials: SA
authors.lastname: McConnell
authors.forename: S R
authors.initials: SR
authors.lastname: Penzak
authors.forename: T S
authors.initials: TS
authors.lastname: Warmack
authors.forename: E J
authors.initials: EJ
authors.lastname: Anaissie
authors.forename: P O
authors.initials: PO
authors.lastname: Gubbins
mesh_terms: D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D015377:Cilastatin / Q000009:adverse effects*; D000077728:Cilastatin, Imipenem Drug Combination; D003429:Cross Reactions; D004338:Drug Combinations; D004342:Drug Hypersensitivity / Q000453:epidemiology* / Q000209:etiology*; D005334:Fever; D006801:Humans; D015378:Imipenem / Q000009:adverse effects*; D015994:Incidence; D008875:Middle Aged; D009503:Neutropenia; D010406:Penicillins / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D004338:Drug Combinations; D010406:Penicillins; D015377:Cilastatin; D015378:Imipenem; D000077728:Cilastatin, Imipenem Drug Combination