Enhanced replication of HIV-1 in vivo in pigtailed macaques (Macaca nemestrina).
Non-human primate models for acquired immunodeficiency syndrome (AIDS) are important for studies of prevention and intervention strategies. Ideally, such models would make use of human immunodeficiency virus type 1 (HIV-1) and animals that are readily available for research. HIV-1 was obtained from an infected macaque, and passaged sequentially in three groups of two Macaca nemestrina neonates each. Evidence for enhanced viral replication was first found in one of the group 2 animals, and in both group 3 animals. Observations that underlie this conclusion are sustained viral recovery from peripheral blood mononuclear cells (PBMCs), increased and accelerated production of antiviral antibodies, and the ability to detect plasma viral ribonucleic acid (RNA) months after infection. There was no evidence of CD4 depletion in any of the animals during the follow-up period. These data suggest that a useful non-human primate model for AIDS can be attained in pigtailed macaques (M. nemestrina).
Bosch
M L
ML
Department of Pathobiology, University of Washington, Seattle 98105, USA.
Schmidt
A
A
Chen
J
J
Florey
M J
MJ
Agy
M
M
Morton
W R
WR
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology*; D000595:Amino Acid Sequence; D000818:Animals; D018791:CD4 Lymphocyte Count; D016384:Consensus Sequence; D004195:Disease Models, Animal; D015686:Gene Products, env / Q000235:genetics; D015752:Genes, env; D014644:Genetic Variation; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology*; D008254:Macaca nemestrina; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load; D014779:Virus Replication
D015686:Gene Products, env; D015483:HIV Antibodies; D012367:RNA, Viral