title: 5,6-Diaminocytidine, a versatile synthon for pyrimidine-based bicyclic nucleosides.
abstract: This communication describes a convenient, facile, and high-yield synthesis of 3-(beta-D-ribofuranosyl)isoguanine and its 8-methyl derivative, as well as nucleoside analogues of pteridines, from a common precursor, 5,6-diaminocytidine. 5,6-Diamino-2',3', 5'-tri-O-benzoylcytidine was synthesized from 4, 6-diamino-2-oxopyrimidine in three steps.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, 30 S. 2000 E, 201 Skaggs Hall, Salt Lake City, Utah 84112, USA.
authors.forename: K G
authors.initials: KG
authors.lastname: Rajeev
authors.forename: A D
authors.initials: AD
authors.lastname: Broom
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011621:Pteridines / Q000138:chemical synthesis; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*
chemical_list: C418324:5,6-diaminocytidine; D001643:Bridged Bicyclo Compounds; D007202:Indicators and Reagents; D011621:Pteridines; D011741:Pyrimidine Nucleosides; D003562:Cytidine