title: Helicobacter pylori eradication dramatically improves inflammation in the gastric cardia.
abstract: OBJECTIVE
  Inflammation of the gastric cardia, i.e., "carditis," has been associated with Helicobacter pylori (H. pylori) infection; however, some investigators believe carditis to be a histological marker for gastroesophageal reflux disease. The aim of this study was to investigate the role of H. pylori eradication on the grade of carditis scored according to the updated Sydney classification.
  
  
  METHODS
  Consecutive patients presenting for upper endoscopy underwent systematic gastric biopsies (eight antral, 12 corpus, and four cardia). Patients with H. pylori infection and carditis were identified and followed prospectively before and after H. pylori treatment. At pretreatment and, on average, 2 yr after eradication of H. pylori, the degree of inflammation in the gastric cardia and H. pylori status were blindly assessed by a single pathologist.
  
  
  RESULTS
  A total of 31 patients with H. pylori infection and carditis were identified. The mean age was 70 yr (range: 37-81 yr); all were male. Four were African-American and 27 were Caucasian. All patients were treated with standard anti-H. pylori therapy, including a proton pump inhibitor in combination with two antibiotics for 2 wk. Eradication of H. pylori was successful in 23 patients (group I), whereas eight patients had persistent infection (group II). Patients were followed after eradication therapy for a mean of 23.2 months (range: 6-48 months). After eradication therapy, there was a significant decrease (p < 0.0001) in the carditis scores (activity and inflammation scores) in group I, whereas the scores remained unchanged in group II patients. In both groups, there were no significant changes in the degree of intestinal metaplasia or atrophy. There were four patients with intestinal metaplasia, and one with atrophy.
  
  
  CONCLUSIONS
  There is a dramatic improvement in the degree of inflammation and activity scores in the gastric cardia of patients with successful H. pylori eradication compared to those with persistent infection. By fulfilling one of Koch's postulates (i.e., improvement in the disease after cure of the possible etiological organism), these data support H. pylori as being the etiological agent for carditis in this group of patients.
authors.affiliation: Department of Medicine, University of Kansas and VA Medical Center, Kansas City 64128, USA.
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: M
authors.initials: M
authors.lastname: Topalovski
authors.forename: M S
authors.initials: MS
authors.lastname: Mayo
authors.forename: R E
authors.initials: RE
authors.lastname: Sampliner
authors.forename: A P
authors.initials: AP
authors.lastname: Weston
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents; D001706:Biopsy; D002299:Cardia / Q000473:pathology; D016022:Case-Control Studies; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005500:Follow-Up Studies; D005756:Gastritis / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D054328:Proton Pump Inhibitors; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors