title: Heme oxygenase1 (HSP-32) is induced in myelin-phagocytosing Schwann cells of injured sciatic nerves in the rat.
abstract: Schwann cells participate in myelin phagocytosis in the early stage of Wallerian degeneration, prior to the recruitment of macrophages. This is the first report that Schwann cells induce heme oxygenase-1 (HO-1), a 32-kDa heat shock protein, only when they have transformed into myelin-phagocytosing cells from myelinating cells (days 2-3) immediately after crush injury of rat sciatic nerves. Double immunofluorescent labelling for HO-1 and transferrin receptors revealed that HO-1-immunoreactive Schwann cells also expressed transferrin receptors suggesting activation of iron metabolism. The transient induction of HO-1 in Schwann cells may contribute to the adaptive function in an altered environment when the cells have lost contact with axons, and may play a crucial role in the ensuing regeneration.
authors.affiliation: Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Maidashi 3-1-1, Fukuoka, 812-8582, Japan. hirata@anat1.med.kyushu-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: J W
authors.initials: JW
authors.lastname: He
authors.forename: A
authors.initials: A
authors.lastname: Kuraoka
authors.forename: Y
authors.initials: Y
authors.lastname: Omata
authors.forename: M
authors.initials: M
authors.lastname: Hirata
authors.forename: A T
authors.initials: AT
authors.lastname: Islam
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: M
authors.initials: M
authors.lastname: Kawabuchi
mesh_terms: D000818:Animals; D004790:Enzyme Induction; D006419:Heme Oxygenase (Decyclizing) / Q000096:biosynthesis*; D051547:Heme Oxygenase-1; D008297:Male; D009186:Myelin Sheath / Q000502:physiology*; D009409:Nerve Crush; D051381:Rats; D017208:Rats, Wistar; D012583:Schwann Cells / Q000201:enzymology / Q000502:physiology*; D012584:Sciatic Nerve / Q000201:enzymology / Q000293:injuries / Q000502:physiology*; D014855:Wallerian Degeneration
chemical_list: D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1