title: The effects of syringe plunger design on drug delivery during vertical displacement of syringe pumps.
abstract: Fluid delivery from four types of commercially available 50-ml syringes was measured using an electronic balance at an infusion rate of 1 ml.h(-1). Retrograde aspiration volume and zero-drug delivery time were recorded after lowering the syringe pump by 50 cm. Syringe compliance was calculated from the volume of bolus released after occlusion at 100 mmHg. Zero-drug delivery times differed significantly between syringes, ranging from [mean (SD)] 3.26 (0.40) min to 6.38 (0.56) min (F = 55.5, d.f. = 3/20, p < 0.0001). Syringe compliance correlated well with aspiration volume (Pearson r(2) = 0.92, p < 0.001) and zero-drug delivery time (r(2) = 0.90, p < 0.001). Syringe design affected the internal syringe compliance. All syringes were associated with potentially relevant zero-drug delivery times after moderate vertical displacement. To minimise this risk, vertical displacement of syringe pumps delivering highly vasoactive drugs should be avoided.
authors.affiliation: Department of Intensive Care and Neonatology, University Children's Hospital, Steinwiesstrase 75, CH-8032 Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Weiss
authors.forename: J
authors.initials: J
authors.lastname: Fischer
authors.forename: T
authors.initials: T
authors.lastname: Neff
authors.forename: O
authors.initials: O
authors.lastname: Baenziger
mesh_terms: D003187:Compliance; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D006874:Hydrostatic Pressure; D013594:Syringes