title: [Anemia, subcutaneous bleeding and weight loss. Disseminated metastasizing, mucinous adenocarcinoma of the stomach].
abstract: A 69 years old female patient was admitted to the hospital with anemia, loss of appetite and weight since three months. The physical examination showed extended cutaneous bleedings. Laboratory tests revealed a hemolytic anemia with fragmented erythrocytes. The bone marrow examination was characterized by erythroid hyperplasia and an invasion by mucin-producing adenocarcinoma cells. Upper endoscopy detected a small hiatal hernia with mucosal erosions between esophagus and stomach. The histology of the mucosal biopsy identified a poorly differentiated mucin-producing adenocarcinoma with portions of signet-ring cells. X-ray examination revealed osteoplastic bone metastases of the vertebrae and of the pelvis. We diagnosed a disseminated, mucin-producing adenocarcinoma of the stomach, associated with microangiopathic hemolytic anemia. In spite of rapidly begun chemotherapy with adriamycin and daily blood transfusions the woman died after four weeks.
authors.affiliation: Medizinische Klinik, Regionalspital, Langenthal. hMauron@gmx.ch
authors.forename: H
authors.initials: H
authors.lastname: Mauron
authors.forename: R
authors.initials: R
authors.lastname: Streuli
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology / Q000556:secondary*; D000368:Aged; D000743:Anemia, Hemolytic / Q000209:etiology* / Q000473:pathology; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000473:pathology / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011693:Purpura / Q000209:etiology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology*; D015431:Weight Loss / Q000502:physiology*