The safety of a ginger extract in the rat.
In three different studies on rats, the effects of a patented standardised ginger extract, EV.EXT 33, on blood glucose, blood coagulation, blood pressure and heart rate were investigated. EV.EXT 33 had no significant effect on blood glucose levels at the doses used. It also had no significant effects on coagulation parameters or on Warfarin-induced changes in blood coagulation, indicating that it did not interact with Warfarin. EV.EXT 33 neither decreases systolic blood pressure nor increases heart rate in the rat. As also seen from the literature, ginger is thus pharmacologically safe regarding the investigated aspects.
Weidner
M S
MS
Institute of Drug Analysis A/S, Symbion Science Park, Fruebjergvej 3, DK-2100, Copenhagen, Denmark. msw.ida@symbion.dk
Sigwart
K
K
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D004347:Drug Interactions; D020939:Zingiber officinale / Q000737:chemistry*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D014859:Warfarin / Q000494:pharmacology
D000925:Anticoagulants; D001786:Blood Glucose; D010936:Plant Extracts; D014859:Warfarin