Parallel synthesis of isatin-based serine protease inhibitors.
The synthesis of N-functionalised isatins using parallel, solution synthesis is described. Functionalised polymers were employed as stoichiometric and catalytic reagents as well as purification media in the exercise, and the derivatives were screened against a panel of serine proteases; high percentage inhibition was observed in several cases.
Shuttleworth
S J
SJ
BioChem Pharma Inc., Laval, Quebec, Canada. sjshuttleworth@earthlink.net
Nasturica
D
D
Gervais
C
C
Siddiqui
M A
MA
Rando
R F
RF
Lee
N
N
D007510:Isatin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry
D015842:Serine Proteinase Inhibitors; D007510:Isatin