title: Lower hookworm incidence, prevalence, and intensity of infection in children with a Bacillus Calmette-Guérin vaccination scar.
abstract: Bacillus Calmette-Guérin (BCG), the most common vaccine worldwide, has broad effects on the immune system. Hookworm infections are a major source of morbidity. In response to a preliminary report of BCG vaccination protection against nematodes in human immunodeficiency virus-infected adults, data from an ongoing prospective study were analyzed to determine the intensity (eggs per gram of stool), prevalence, and incidence of different helminths in children with and without a BCG vaccination scar. Adjusted prevalence and incidence ratios were estimated by using logistic regression. Children with a BCG vaccination scar were found to have statistically significantly lower hookworm prevalence (41%), incidence (37%), and mean egg counts (39%), after controlling for age, sex, and socioeconomic factors. There was no BCG association with incidence, prevalence, or intensity of infection with Schistosoma mansoni, Ascaris lumbricoides, or Trichuris trichiura. Such protection would have implications for public health and for research on mechanisms behind human immunological responses to hookworm.
authors.affiliation: Instituto de Saúde Coletiva/UFBa, Rua Padre Feijó, 29/4o andar-Canela 40.110-170 Salvador, Bahia Brazil. mauricio@ufba.br
authors.forename: M L
authors.initials: ML
authors.lastname: Barreto
authors.forename: L C
authors.initials: LC
authors.lastname: Rodrigues
authors.forename: R C
authors.initials: RC
authors.lastname: Silva
authors.forename: A M
authors.initials: AM
authors.lastname: Assis
authors.forename: M G
authors.initials: MG
authors.lastname: Reis
authors.forename: C A
authors.initials: CA
authors.lastname: Santos
authors.forename: R E
authors.initials: RE
authors.lastname: Blanton
mesh_terms: D000293:Adolescent; D000818:Animals; D017164:Ascaris lumbricoides / Q000302:isolation & purification; D001500:BCG Vaccine; D001938:Brazil / Q000453:epidemiology; D002648:Child; D005243:Feces / Q000469:parasitology; D005500:Follow-Up Studies; D006725:Hookworm Infections / Q000453:epidemiology* / Q000469:parasitology; D006801:Humans; D015994:Incidence; D007411:Intestinal Diseases, Parasitic / Q000453:epidemiology* / Q000469:parasitology; D010270:Parasite Egg Count; D015995:Prevalence; D012550:Schistosoma mansoni / Q000302:isolation & purification; D014258:Trichuris / Q000302:isolation & purification; D014611:Vaccination
chemical_list: D001500:BCG Vaccine