title: CDK-related protein kinases in plants.
abstract: Cyclin-dependent kinases (CDK) form a conserved superfamily of eukaryotic serine-threonine protein kinases, which require binding to a cyclin protein for activity. CDK are involved in different aspects of cell biology and notably in cell cycle regulation. The comparison of nearly 50 plant CDK-related cDNAs with a selected set of their animal and yeast counterparts reveals five classes of these genes in plants. These are described here with respect to their phylogenetic, structural and functional properties. A plant-wide nomenclature of CDK-related genes is proposed, using a system similar to that of the plant cyclin genes. The most numerous class, CDKA, includes genes coding for CDK with the PSTAIRE canonical motif. CDKB makes up a class of plant-specific CDK divided into two groups: CDKB1 and CDKB2. CDKC, CDKD and CDKE form less numerous classes. The CDKD class includes the plant orthologues of metazoan CDK7, which correspond to the CDK-activating kinase (CAK). At present, no functional information is available in plants for CDKC and CDKE.
authors.affiliation: Laboratory of Plant Physiology, National Institute for Agronomic Research INRA, Villenave d'Ornon, France .
authors.forename: J
authors.initials: J
authors.lastname: Joubès
authors.forename: C
authors.initials: C
authors.lastname: Chevalier
authors.forename: D
authors.initials: D
authors.lastname: Dudits
authors.forename: E
authors.initials: E
authors.lastname: Heberle-Bors
authors.forename: D
authors.initials: D
authors.lastname: Inzé
authors.forename: M
authors.initials: M
authors.lastname: Umeda
authors.forename: J P
authors.initials: JP
authors.lastname: Renaudin
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D017343:Genes, Plant; D008969:Molecular Sequence Data; D010766:Phosphorylation; D010802:Phylogeny; D010944:Plants / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D009626:Terminology as Topic; D015003:Yeasts / Q000201:enzymology
chemical_list: D018844:Cyclin-Dependent Kinases