title: A physiologically based toxicokinetic model for lake trout (Salvelinus namaycush).
abstract: A physiologically based toxicokinetic (PB-TK) model for fish, incorporating chemical exchange at the gill and accumulation in five tissue compartments, was parameterized and evaluated for lake trout (Salvelinus namaycush). Individual-based model parameterization was used to examine the effect of natural variability in physiological, morphological, and physico-chemical parameters on model predictions. The PB-TK model was used to predict uptake of organic chemicals across the gill and accumulation in blood and tissues in lake trout. To evaluate the accuracy of the model, a total of 13 adult lake trout were exposed to waterborne 1,1,2,2-tetrachloroethane (TCE), pentachloroethane (PCE), and hexachloroethane (HCE), concurrently, for periods of 6, 12, 24 or 48 h. The measured and predicted concentrations of TCE, PCE and HCE in expired water, dorsal aortic blood and tissues were generally within a factor of two, and in most instances much closer. Variability noted in model predictions, based on the individual-based model parameterization used in this study, reproduced variability observed in measured concentrations. The inference is made that parameters influencing variability in measured blood and tissue concentrations of xenobiotics are included and accurately represented in the model. This model contributes to a better understanding of the fundamental processes that regulate the uptake and disposition of xenobiotic chemicals in the lake trout. This information is crucial to developing a better understanding of the dynamic relationships between contaminant exposure and hazard to the lake trout.
authors.affiliation: National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, U.S. Environmental Protection Agency, Duluth, MN, USA. lien.gregory@epa.gov
authors.forename: G J
authors.initials: GJ
authors.lastname: Lien
authors.forename: J M
authors.initials: JM
authors.lastname: McKim
authors.forename: A D
authors.initials: AD
authors.lastname: Hoffman
authors.forename: C T
authors.initials: CT
authors.lastname: Jenson
mesh_terms: D000465:Algorithms; D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D066298:In Vitro Techniques; D008954:Models, Biological; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D014118:Toxins, Biological / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity*; D014337:Trout / Q000378:metabolism*
chemical_list: D014118:Toxins, Biological