title: A case of insulin dependent diabetes mellitus following systemic treatment for Vogt-Koyanagi-Harada syndrome.
abstract: A 29-year-old man developed acute visual impairment, cough, and headache. Both eyes showed serous retinal detachment in the posterior fundus. Fluorescein angiography showed subretinal pooling of fluorescein in the late phase. A diagnosis of Vogt-Koyanagi-Harada (VKH) syndrome was made based on clinical features. Treatment with systemic corticosteroids resulted in improvement of uveitis and both eyes showed "sunset glow" fundus 11 months later. Insulin-dependent diabetes mellitus (IDDM) developed 13 months later (3 months after systemic corticosteroid therapy). Despite treatment with insulin, glycemic control was poor. Human leukocyte antigen (HLA) typing showed HLADR9 and DQB 1*0303 related to IDDM. We postulated that treatment with corticosteroids precipitated IDDM, a yet unknown common autoimmune mechanism might have caused IDDM and VKH, or both conditions occurred coincidentally.
authors.affiliation: Department of Ophthalmology, Hamamatsu Medical Center, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Iino
authors.forename: Y
authors.initials: Y
authors.lastname: Kora
mesh_terms: D000328:Adult; D001623:Betamethasone / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000139:chemically induced* / Q000276:immunology; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000009:adverse effects*; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008297:Male; D011379:Prognosis; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology
chemical_list: D001786:Blood Glucose; D005938:Glucocorticoids; D006680:HLA Antigens; D007328:Insulin; D001623:Betamethasone