title: Extended extracorporeal photochemotherapy with extracorporeal administration of 8-methoxypsoralen in systemic sclerosis. An Austrian single-center study.
abstract: BACKGROUND
  Extracorporeal photochemotherapy (EXP) is an immunomodulating therapy that has been used in a limited number of patients with systemic sclerosis (SSC) with controversial results. The present study was performed to evaluate the efficacy and safety of extended EXP with extracorporeal application of liquid 8-methoxypsoralen (8-MOP) in the treatment of SSC.
  
  
  METHODS
  Eleven women with progressive SSC of recent onset were treated for a period of 16-57 months. Skin changes, physical performance, extracutaneous manifestations, and quality of life were evaluated before initiation of EXP and at regular intervals thereafter.
  
  
  RESULTS
  From the start to the last set of EXP, we observed an overall improvement and/or stabilization of skin changes and physical performance in 5 of 11 patients (45%). Extracutaneous manifestations deteriorated in 10 of 11 patients (91%) (P<0.05), and quality of life deteriorated in 9 of 11 patients (82%) from a mean score of 10 before, to 17 at the last set of EXP (P<0.05). No major side effects were noted.
  
  
  CONCLUSIONS
  Extended EXP with extracorporeal administration of 8-MOP is a safe and well tolerated treatment modality. However, it provides only (minor) improvement of skin changes of a subset of SSC patients and does not beneficially influence extracutaneous manifestations and quality of life.
authors.affiliation: Department of Dermatology, Karl-Franzens University School of Medicine, Graz, Austria. robert.muellegger@kfunigraz.ac.at
authors.forename: R R
authors.initials: RR
authors.lastname: Muellegger
authors.forename: A
authors.initials: A
authors.lastname: Hofer
authors.forename: W
authors.initials: W
authors.lastname: Salmhofer
authors.forename: H P
authors.initials: HP
authors.lastname: Soyer
authors.forename: H
authors.initials: H
authors.lastname: Kerl
authors.forename: P
authors.initials: P
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000368:Aged; D001317:Austria; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008730:Methoxsalen / Q000008:administration & dosage; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage; D011788:Quality of Life; D012595:Scleroderma, Systemic / Q000188:drug therapy*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014467:Ultraviolet Therapy
chemical_list: D017319:Photosensitizing Agents; D008730:Methoxsalen