Calciphylaxis in a patient without renal failure or elevated parathyroid hormone: possible aetiological role of chemotherapy.
Calciphylaxis is a rare, often fatal disease characterized clinically by progressive cutaneous necrosis and ulceration, and histologically by vascular calcification and thrombosis. It has been described in association with end-stage renal disease, after initiation of dialysis, following renal transplantation, and in patients with hyperparathyroidism. We present the first case of calciphylaxis occurring in a patient with both normal renal function and parathyroid hormone level and discuss the possible aetiological role of chemotherapy-induced functional protein C and protein S deficiency.
Goyal
S
S
Department of Dermatology, The Johns Hopkins University, School of Medicine, 601 North Caroline Street, Baltimore, MD 21287-0900, USA.
Huhn
K M
KM
Provost
T T
TT
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D002115:Calciphylaxis / Q000139:chemically induced*; D003875:Drug Eruptions / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000139:chemically induced*; D008875:Middle Aged