title: [Evaluation of gonadal function in post-pubertal patients after bone marrow transplantation during childhood objective].
abstract: OBJECTIVE
  To evaluate the effect of bone marrow transplantation during childhood on gonadal function in postpubertal patients.
  
  
  METHODS
  We studied 19 post-pubertal patients (13 males, 6 females) aged 13-20 years, 2-9 years after bone marrow transplantation for diverse diseases. Fifteen patients had received multi-agent cytotoxic treatment and 6 had received cranial irradiation prior to transplantation; eleven patients received total body irradiation. Gonadal function was assessed by typifying Tanner's stages of pubertal development and by measuring testicular volume in males (Prader's orchidometer). Serum concentrations of luteinizing hormone, follicle-stimulating hormone, testosterone and 17-beta-estradiol were also measured.
  
  
  RESULTS
  Twelve patients were found to have gonadal dysfunction of gonadal origin. Of these, three had not received total body irradiation.
  
  
  CONCLUSIONS
  The results obtained show that gonadal dysfunction is frequent in patients treated with bone marrow transplantation. This damage can be attributed to both chemo- and radiotherapy but a synergistic effect between these treatments could not be excluded. The prepubertal status of patients at the moment of transplantation was not a protective factor against chemo- or radiotherapy-induced gonadal damage in our series.
authors.affiliation: Unidad de Endocrinología Pediátrica, Servicio de Pediatría, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Pérez Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: Alonso Blanco
authors.forename: E
authors.initials: E
authors.lastname: Otheo De Tejada Barasoain
authors.forename: M A
authors.initials: MA
authors.lastname: Maldonado Regalado
authors.forename: A
authors.initials: A
authors.lastname: Muñoz Villa
authors.forename: R
authors.initials: R
authors.lastname: Barrio Castellanos
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011627:Puberty / Q000502:physiology; D012737:Sex Factors; D013737:Testis / Q000187:drug effects / Q000528:radiation effects; D019172:Transplantation Conditioning / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone