title: Physical and transcriptional mapping of the 17p13.3 region that is frequently deleted in human cancer.
abstract: Studies of chromosomal losses at 17p13 have suggested the presence of at least two distinct regions for tumor suppressor genes, the TP53 region at 17p13.1 and a more distal region at 17p13.3. Within the latter region, Hypermethylated in Cancer 1 (HIC1) is located, a likely candidate for a tumor suppressor gene that has also been suggested to play a role in the pathogenesis of Miller-Diecker syndrome (MDS). However, single-gene isolation efforts have retrieved additional genes from 17p13.3 that could play a role in tumorigenesis. This indicates that the full potential of this chromosomal region with respect to disease-related genes has not yet been exhausted and that there may exist still unknown genes that contribute to tumorigenesis or to the complex MDS phenotype. To provide a basis for the systematic isolation and evaluation of such genes, we established a physical map over 1.5 Mb of 17p13.3 and assigned 29 transcriptional units within this region.
authors.affiliation: Abteilung Molekulare Genomanalyse, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hoff
authors.forename: P
authors.initials: P
authors.lastname: Seranski
authors.forename: J
authors.initials: J
authors.lastname: Mollenhauer
authors.forename: B
authors.initials: B
authors.lastname: Korn
authors.forename: T
authors.initials: T
authors.lastname: Detzel
authors.forename: R
authors.initials: R
authors.lastname: Reinhardt
authors.forename: J
authors.initials: J
authors.lastname: Ramser
authors.forename: A
authors.initials: A
authors.lastname: Poustka
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D020224:Expressed Sequence Tags; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051741:Kruppel-Like Transcription Factors; D019656:Loss of Heterozygosity; D008969:Molecular Sequence Data; D009857:Oncogenes; D013577:Syndrome; D014157:Transcription Factors / Q000235:genetics
chemical_list: C096870:Hic1 protein, mouse; D051741:Kruppel-Like Transcription Factors; D014157:Transcription Factors