HIV-Inhibitory prenylated xanthones and flavones from Maclura tinctoria.
The organic extract of the plant Maclura tinctoria exhibited moderate anti-HIV activity. Seven prenylated phenolic derivatives were isolated from the active fractions and characterized by spectroanalytical methods. New compounds macluraxanthone B (1), macluraxanthone C (2), and dihydrocudraflavone B (8) were identified.
Groweiss
A
A
Laboratory of Drug Discovery Research and Development, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Cardellina
J H
JH
Boyd
M R
MR
D019380:Anti-HIV Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002725:Chloroform; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000032:analysis; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014966:Xanthenes / Q000302:isolation & purification* / Q000494:pharmacology; D014970:Xanthines / Q000302:isolation & purification* / Q000494:pharmacology*; D044004:Xanthones
D019380:Anti-HIV Agents; D005419:Flavonoids; D010936:Plant Extracts; D014966:Xanthenes; D014970:Xanthines; D044004:Xanthones; C419730:dihydrocudraflavone B; C419728:macluraxanthone B; C419729:macluraxanthone C; D002725:Chloroform