title: A new antiplasmodial coumarin from Toddalia asiatica roots.
abstract: A new antiplasmodial coumarin, 5,7-dimethoxy-8-(3'-hydroxy-3'methyl-1'-butene)-coumarin (1), has been isolated from the roots of Toddalia asiatica. This finding supports the traditional use of this plant for the treatment of malaria.
authors.affiliation: Department of Pharmacology and Pharmacognosy, Faculty of Pharmacy, College of Health Sciences, University of Nairobi, P.O. Box 19676, Nairobi, Kenya. heoketch@africaonline.co.ke
authors.forename: H A
authors.initials: HA
authors.lastname: Oketch-Rabah
authors.forename: J W
authors.initials: JW
authors.lastname: Mwangi
authors.forename: J
authors.initials: J
authors.lastname: Lisgarten
authors.forename: E K
authors.initials: EK
authors.lastname: Mberu
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D016488:Medicine, African Traditional; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: C426660:5,7-dimethoxy-8-(3'-hydroxy-3'-methyl-1'-butene)coumarin; D000962:Antimalarials; D003374:Coumarins; D010936:Plant Extracts; C030123:coumarin