Inhibitors of src tyrosine kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines.
Src is a nonreceptor tyrosine kinase involved in signaling pathways that control proliferation, migration, and angiogenesis. Increased Src expression and activity are associated with an increase in tumor malignancy and poor prognosis. Several quinolines and quinazolines were identified as potent and selective inhibitors of Src kinase activity.
Wang
Y D
YD
Chemical Sciences and Oncology, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. wangd@war.wyeth.com
Miller
K
K
Boschelli
D H
DH
Ye
F
F
Wu
B
B
Floyd
M B
MB
Powell
D W
DW
Wissner
A
A
Weber
J M
JM
Boschelli
F
F
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D019061:src-Family Kinases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D011799:Quinazolines; D011804:Quinolines; D019061:src-Family Kinases