title: TVB receptors for cytopathic and noncytopathic subgroups of avian leukosis viruses are functional death receptors.
abstract: The identification of TVB(S3), a cellular receptor for the cytopathic subgroups B and D of avian leukosis virus (ALV-B and ALV-D), as a tumor necrosis factor receptor-related death receptor with a cytoplasmic death domain, provides a compelling argument that viral Env-receptor interactions are linked to cell death (4). However, other TVB proteins have been described that appear to have similar death domains but are cellular receptors for the noncytopathic subgroup E of ALV (ALV-E): TVB(T), a turkey subgroup E-specific ALV receptor, and TVB(S1), a chicken receptor for subgroups B, D, and E ALV. To begin to understand the role of TVB receptors in the cytopathic effects associated with infection by specific ALV subgroups, we asked whether binding of a soluble ALV-E surface envelope protein (SU) to its receptor can lead to cell death. Here we report that ALV-E SU-receptor interactions can induce apoptosis in quail or turkey cells. We also show directly that TVB(S1) and TVB(T) are functional death receptors that can trigger cell death by apoptosis via a mechanism involving their cytoplasmic death domains and activation of the caspase pathway. These data demonstrate that ALV-B and ALV-E use functional death receptors to enter cells, and it remains to be determined why only subgroups B and D viral infections lead specifically to cell death.
authors.affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: J
authors.initials: J
authors.lastname: Brojatsch
authors.forename: J
authors.initials: J
authors.lastname: Naughton
authors.forename: H B
authors.initials: HB
authors.lastname: Adkins
authors.forename: J A
authors.initials: JA
authors.lastname: Young
mesh_terms: D000818:Animals; D001354:Avian Leukosis Virus / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D002460:Cell Line; D006801:Humans; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D011991:Receptors, Virus / Q000502:physiology*; D014779:Virus Replication
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D011991:Receptors, Virus