Lyprinol: anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea.
Lyprinol exhibits anti-inflammatory activity distinct from that of most NSAIDs, controlling chronic but not acute inflammation. Unlike Cox-1 inhibitors (aspirin, meclofenamic acid) it is not gastro-toxic. Predosing rats with Lyprinol can modify both (i) the spontaneous and (ii) the oxytocin-induced contractions of the uterus. In humans there is anecdotal evidence that Lyprinol can relieve dysmenorrhea. This report explores the concept that the uterotrophic actions of Lyprinol are conditioned by: the intrinsic profile of estrogenic hormones and progestagens and, certain extrinsic stimuli. Evidence from in vitro studies indicates that Lyprinol is not a smooth muscle relaxant and that its uterotrophic mechanism is not that of a cyclo-oxygenase inhibitor, but may mimic that of a leukotriene receptor antagonist.
Shiels
I A
IA
Department of Pharmacology, University of Queensland Brisbane, Australia.
Whitehouse
M W
MW
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D049872:Bivalvia / Q000737:chemistry*; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004412:Dysmenorrhea / Q000188:drug therapy*; D004971:Estrus / Q000187:drug effects; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D006727:Hormone Antagonists / Q000494:pharmacology; D007213:Indomethacin / Q000627:therapeutic use; D020024:Leukotriene Antagonists; D008055:Lipids / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D008954:Models, Biological; D009126:Muscle Relaxation / Q000187:drug effects*; D009215:Myometrium / Q000187:drug effects*; D009520:New Zealand; D010052:Ovariectomy; D010121:Oxytocin / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D012739:Gonadal Steroid Hormones; D006727:Hormone Antagonists; D020024:Leukotriene Antagonists; D008055:Lipids; C418997:lyprinol; D010121:Oxytocin; D007213:Indomethacin