Ontogeny of PACAP immunoreactivity in extrinsic and intrinsic innervation of chicken gut.
An immunohistochemical study was conducted on the ontogeny of pituitary adenylate cyclase-activating polypeptide-27 (PACAP) immunoreactive elements within the extrinsic and intrinsic nerve supply of the chicken embryo gut. The first PACAP-immunoreactivity was detected in the extrinsic nerve supply at E 4 within the pharyngeal region and the primary sympathetic chain. At E 5.5 it appeared in the vagus nerve, the spinal cord, the secondary sympathetic chain, some perivascular plexuses and the Remak ganglion. In the intrinsic nerve supply, the first PACAP-immunoreactive elements were shown at E 4.5-E 5 in the mesenchymal bud of the proventriculus/gizzard. Then they gradually appeared also cranially and caudally both in myenteric and submucous plexuses.
Salvi
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EP
Institute of Human Anatomy, University 'La Sapienza', Via A.Borelli 50, 00161, Rome, Italy.
Vaccaro
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Renda
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D000818:Animals; D002642:Chick Embryo; D004064:Digestive System / Q000276:immunology / Q000294:innervation* / Q000378:metabolism*; D005895:Gizzard, Avian / Q000378:metabolism; D007150:Immunohistochemistry; D008648:Mesoderm / Q000378:metabolism; D009479:Neuropeptides / Q000096:biosynthesis* / Q000276:immunology; D018377:Neurotransmitter Agents / Q000096:biosynthesis* / Q000276:immunology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011531:Proventriculus / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism; D013368:Submucous Plexus / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000378:metabolism; D013997:Time Factors; D014630:Vagus Nerve / Q000378:metabolism
D009479:Neuropeptides; D018377:Neurotransmitter Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide