Two new 26,27-cyclosterols from the marine sponge Strongylophora corticata.
Two novel steroids with a cyclopropane ring at C-25 and C-26, 7-oxopetrosterol (1) and 7alpha-hydroxypetrosterol (2), along with two known compounds, petrosterol (3) and 23,24-dihydrocalysterol (4), have been isolated from the Japanese marine sponge Strongylophora corticata. The structures of 1 and 2 were determined as 26, 27-cyclo-24,27-dimethyl-3beta-hydroxycholest-5-en-7-one and 26, 27-cyclo-24,27-dimethylcholest-5-en-3beta,7alpha-diol on the basis of spectroscopic investigations.
Umeyama
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A
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan. umeyama@ph.bunri-u.ac.jp
Ito
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S
Yoshigaki
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A
Arihara
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S
D000818:Animals; D002725:Chloroform; D002777:Cholestanols / Q000302:isolation & purification*; D002783:Cholestenones / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*; D012997:Solvents; D013256:Steroids / Q000302:isolation & purification*
C419731:7-hydroxypetrosterol; C419732:7-oxopetrosterol; D002777:Cholestanols; D002783:Cholestenones; D012997:Solvents; D013256:Steroids; D002725:Chloroform