Large uterine myoma with erythropoietin messenger RNA and erythrocytosis.
BACKGROUND
Myomatous erythrocytosis syndrome (erythrocytosis associated with a uterine myoma) has multiple proposed etiologies, one of which is altered erythropoietin production.


METHODS
A 28-year-old woman, gravida 0, para 0, presented with a solitary, degenerated uterine myoma that was 34-36 weeks' gestational size and erythrocytosis. After GnRH agonist treatment and myomectomy, the tumor was analyzed by reverse transcription-polymerase chain reaction. Specific erythropoietin primer with erythropoietin messenger RNA was noted.


CONCLUSIONS
Erythropoietin production by myomata might cause erythrocytosis in myomatous erythrocytosis syndrome.
Kohama
T
T
Department of Obstetrics and Gynecology, Keiju Medical Center, Nanao, Japan. kohama@yu.incl.ne.jp
Shinohara
K
K
Takahura
M
M
Inoue
M
M
D000328:Adult; D004921:Erythropoietin / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006801:Humans; D007889:Leiomyoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D011086:Polycythemia / Q000150:complications*; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014594:Uterine Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology
D012333:RNA, Messenger; D004921:Erythropoietin