The central regulation of bone remodeling.
For a long time bone remodeling has been thought to be mainly an autocrine-paracrine phenomenon. Yet bone resorption mechanisms are under the control of hormones, suggesting that the same might be true for bone formation. The recent development of molecular endocrinology uncovers a common, central regulation of bone formation, body weight and reproduction mediated by leptin.
Karsenty
G
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Baylor College of Medicine, Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA. karsenty@bcm.tmc.edu
D000818:Animals; D016723:Bone Remodeling / Q000235:genetics* / Q000502:physiology*; D002490:Central Nervous System / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics* / Q000502:physiology*; D006801:Humans