Heat shock protein 47 in renal scarring.
Heat shock protein 47 (HSP47) is a collagen-binding protein, thought to play an essential mechanistic role in the assembly and processing of procollagens. HSP47 is increasingly being implicated in the pathogenesis of several human and experimental fibrotic diseases. HSP47 could mediate increased accumulation of collagens in the fibrotic mass, possibly by regulating increased assembly of procollagens. Therefore, modulation of HSP47 might be a valuable tool for manipulation of some fibrotic diseases, including renal scarring
Razzaque
M S
MS
2nd Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan. razzaque@net.nagasaki-u.ac.jp
Ahsan
N
N
Taguchi
T
T
D002921:Cicatrix / Q000378:metabolism / Q000473:pathology; D003094:Collagen / Q000378:metabolism; D005355:Fibrosis; D050958:HSP47 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism* / Q000473:pathology*
D050958:HSP47 Heat-Shock Proteins; D006360:Heat-Shock Proteins; C494660:SERPINH1 protein, human; D003094:Collagen