Three new scalarane sesterterpenoids from the Okinawan sponge Hyrtios erectus.
Three new scalarane sesterterpenoids-hyrtiolide (1), 16-hydroxyscalarolide (2), and 12-deacetyl-Delta(17)-hyrtial (3), were isolated from Okinawan sponge Hyrtios erectus, along with scalarolide (4) and 12-deacetylhyrtial (5). The structures of new compounds 1-3 were determined by spectroscopic analysis and chemical conversions. Compounds 3 and 5 showed antiproliferative activity toward KB cells.
Miyaoka
H
H
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Nishijima
S
S
Mitome
H
H
Yamada
Y
Y
D000818:Animals; D007564:Japan; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000302:isolation & purification*
D013729:Terpenes