From developmental biology to developmental toxicology.
Progress derived from the human genome project will have tremendous impact on toxicology. Questions concerning genetic susceptibility or resistance to toxic compound exposure and the dissection of the molecular mechanisms involved will be at the forefront of future toxicological research. In recent years, it was recognized that many of the molecular control mechanisms of embryogenesis have been conserved during evolution. The relevance of these observations for toxicology and the application of genetic approaches using mouse mutants as a tool for functional genome analysis are discussed.
Balling
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R
Institute of Mammalian Genetics, GSF-Research Center for Environment and Health, Neuherberg, Germany. balling@gsf.de
Hrabé de Angelis
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M
D000818:Animals; D015509:Developmental Biology / Q000639:trends*; D004330:Drosophila; D004351:Drug Resistance / Q000235:genetics; D005038:Ethylnitrosourea / Q000494:pharmacology / Q000633:toxicity; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D051379:Mice; D016296:Mutagenesis / Q000187:drug effects / Q000235:genetics*; D009153:Mutagens / Q000494:pharmacology / Q000633:toxicity; D010641:Phenotype; D014116:Toxicology / Q000639:trends*; D015262:Xenobiotics / Q000494:pharmacology / Q000633:toxicity
D009153:Mutagens; D015262:Xenobiotics; D005038:Ethylnitrosourea