title: Structure-function relationships in bombinins H, antimicrobial peptides from Bombina skin secretions.
abstract: Skin secretions of amphibia of the Bombina genus contain two families of antimicrobial peptides, the bombinins (bombinin-like peptides) and the bombinins H (H for hydrophobic and hemolytic). The latter family includes a number of peptides containing a D-amino acid in the second position, in addition to their corresponding all L-isomers. The antimicrobial activity of three pairs of bombinin H isomers, H2/H4, H6/H7 and GH-1D/GH-1L, has been investigated. The first two pairs of peptides were actually isolated from the secretion, whereas the third was synthesized according to the sequence deduced from a gene coding for a bombinin-like peptide in Bombina orientalis.
authors.affiliation: Dipartimento di Scienze Biomediche, Università 'G. d'Annunzio', 66100, Chieti, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Mangoni
authors.forename: N
authors.initials: N
authors.lastname: Grovale
authors.forename: A
authors.initials: A
authors.lastname: Giorgi
authors.forename: G
authors.initials: G
authors.lastname: Mignogna
authors.forename: M
authors.initials: M
authors.lastname: Simmaco
authors.forename: D
authors.initials: D
authors.lastname: Barra
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D001001:Anura; D002462:Cell Membrane / Q000187:drug effects; D003593:Cytoplasm / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology; D011188:Potassium / Q000378:metabolism; D012867:Skin / Q000378:metabolism*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013997:Time Factors; D015011:Yersinia pseudotuberculosis / Q000187:drug effects
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; C113470:gene-drived bombinin H-like peptide; D011188:Potassium