The adipose conversion process: regulation by extracellular and intracellular factors.
White adipose tissue regulates lipid metabolism and acts as a secretory organ. Because of its importance for human health and animal production, many studies have attempted to better understand its development at the cellular and molecular levels by culturing preadipose cells in vitro. This synthesis article describes our current knowledge, acquired by this approach, concerning the regulation of the different steps of the adipocyte differentiation program by extracellular (hormones, cytokines, growth factors, retinoids and fatty acids) and intracellular agents (second messengers and transcription factors). The discrepant effects that have been observed for some of these factors are also discussed. This information is very important in the perspective of a better control of fat deposits in human and breeding species.
Boone
C
C
Unité Mixte de Recherche sur le Veau et le Porc, INRA, Saint-Gilles, France. boone@st-gilles.rennes.inra.fr
Mourot
J
J
Grégoire
F
F
Remacle
C
C
D017667:Adipocytes / Q000166:cytology*; D000273:Adipose Tissue / Q000254:growth & development* / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division; D002460:Cell Line; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D009765:Obesity / Q000517:prevention & control*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects; D014157:Transcription Factors / Q000502:physiology
D005227:Fatty Acids; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors