title: Available pathways database (APD): an essential resource for combinatorial biology.
abstract: A relational database, the Available Pathways Database (APD), has been constructed of microbial natural products, their producing strains, and their biosynthetic pathways. The database allows the ready selection of donor strains for combinatorial biology experiments. It provides the same type of resource for combinatorial biology as the Available Chemicals Directory (ACD) does for combinatorial chemical library generation. Its cataloging ability can also provide insight into novel aspects of biosynthetic routes. In particular, no 10-unit Type I polyketides were found in the compilation of this edition of the APD (Version I).
authors.affiliation: Department of Chemistry, Levine Science Research Center, Duke University, Durham, North Carolina 27708-0317, USA. pirrung@chem.duke.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Pirrung
authors.forename: C M
authors.initials: CM
authors.lastname: Silva
authors.forename: J
authors.initials: J
authors.lastname: Jaeger
mesh_terms: D001419:Bacteria / Q000378:metabolism; D001690:Biological Science Disciplines; D016208:Databases, Factual; D005658:Fungi / Q000378:metabolism; D010452:Peptide Biosynthesis