Restoration of immunity with interleukin-2 therapy.
HIV replication can now be effectively suppressed using antiretroviral combination regimens. The search continues, however, for ways to restore the immune response and eliminate reservoirs of latent infection. Interleukin-2 (IL-2) may augment the immune response in HIV-infected persons. This article discusses the rationale for using IL-2 in those with HIV disease and reviews key trials of IL-2 treatment regimens.
Smith
K A
KA
Department of Medicine, Weill Medical College of Cornell University, New York, USA.
Jacobson
E L
EL
Emert
R
R
Giordano
M
M
Kovacs
E
E
Mumneh
N
N
Pilaro
F
F
Sohn
T
T
Warren
D
D
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007109:Immunity / Q000187:drug effects; D007167:Immunotherapy; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000187:drug effects / Q000276:immunology; D017735:Virus Latency / Q000187:drug effects / Q000276:immunology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2