["Hetero to homo" allogeneic bone marrow transplantation from a related donor with two HLA loci mismatch].
We describe a 46-year-old HLA-homozygous female patient with CML who received a bone marrow transplant from her son, who had two HLA (A, B) loci mismatch. After conditioning with total body irradiation plus cyclophosphamide, the patient received 4.8 x 10(8) bone marrow cells/kg. Cyclosporin and short-term methotrexate were used for GVHD prophylaxis. She successfully established rapid engraftment with no acute GVHD, and later developed chronic but mild GVHD. Family members with two HLA loci mismatch may be considered as candidate donors for "hetero to homo" bone marrow transplantation.
Kawano
R
R
Department of Hematology, National Kyushu Cancer Center Hospital.
Kimura
M
M
Noguchi
Y
Y
Goto
T
T
Takatsuki
H
H
Yufu
Y
Y
Uike
N
N
D016026:Bone Marrow Transplantation; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000628:therapy; D008875:Middle Aged
D015234:HLA-A Antigens; D015235:HLA-B Antigens