[The influence of hormone replacement therapy (HRT) on bone density in menopausal women in relation to vitamin D receptor (VDR) and estrogen receptor (ER)].
The aim of the study was determination of VDR and ER alleles combination in woman with primary osteoporosis and estimation of bone mass increment after one year of estro-progestagen cyclic therapy enriched with vitamin D analogues, diet containing of calcium and regular physical exercises. The greatest mean BMD was obtained woman without detected polymorphism in VDR and ER genes.
Brodowska
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A
D015519:Bone Density / Q000187:drug effects* / Q000502:physiology; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D010024:Osteoporosis / Q000175:diagnosis / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D014807:Vitamin D / Q000235:genetics / Q000378:metabolism*
D011960:Receptors, Estrogen; D014807:Vitamin D