Synthesis of galactosyl and lactosyl derivatives as potential anti-metastasis compounds.
Based on the known anti-metastasis activities of lactosides and galactosides, a galactosyl and a lactosyl trimannoside were prepared via the conventional Koenigs-Knorr and trichloroacetimidate methods, respectively. Through typical deblocking procedures, a tetrasaccharide alpha-D-Galp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 and a pentasaccharide beta-D-Galp-(1 --> 4)-beta-D-Glcp-(1 --> 2)-alpha-D-Manp-(1 --> 2)-alpha-D-Manp-(1 --> 6)-alpha-D-ManpOCH3 were obtained.
Li
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H
Department of Bioorganic Chemistry, School of Pharmaceutical Sciences, Beijing Medical University, PR China.
Li
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Q
Cai
M S
MS
Li
Z J
ZJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D005697:Galactosides / Q000138:chemical synthesis*; D006027:Glycosides / Q000138:chemical synthesis*; D008362:Mannosides / Q000737:chemistry; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis / Q000517:prevention & control; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry
D000970:Antineoplastic Agents; D005697:Galactosides; D006027:Glycosides; D008362:Mannosides; D009844:Oligosaccharides; C008245:lactosides