title: Apparent diffusion coefficient measurements in progressive supranuclear palsy.
abstract: We measured the apparent diffusion coefficient (ADC), using diffusion-weighted imaging (DWI) and signal intensity on T2-weighted MRI in the cerebral white matter of patients with progressive supranuclear palsy (PSP) and age-matched normal subjects. In PSP, ADC in the prefrontal and precentral white matter was significantly higher than in controls. There was no significant difference in signal intensity on T2-weighted images. The ADC did correlate with signal intensity. The distribution of the elevation of ADC may be the consequence of underlying pathological changes, such as neurofibrillary tangles or glial fibrillary tangles in the cortex. Our findings suggest that ADC measurement might be useful for demonstrating subtle neuropathological changes.
authors.affiliation: Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan. ohshitat@mcai.med.hiroshima-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Ohshita
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: Y
authors.initials: Y
authors.lastname: Imon
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Mimori
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D004058:Diffusion; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology; D017397:Prefrontal Cortex / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis*