AB(5) toxins: structures and inhibitor design.
High-resolution crystal structures of AB(5) toxins in their native form or in complex with a variety of ligands have led to the structure-based design and discovery of inhibitors targeting different areas of the toxins. The most significant progress is the development of highly potent multivalent ligands that block binding of the toxins to their receptors.
Fan
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Department of Biological Structure, Biomolecular Structure Center, WA Seattle, WA 98195, USA.
Merritt
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EA
Verlinde
C L
CL
Hol
W G
WG
D001427:Bacterial Toxins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D008565:Membrane Proteins / Q000378:metabolism; D011487:Protein Conformation
D001427:Bacterial Toxins; D008565:Membrane Proteins