[Free intracellular magnesium in myocardium--measurement and physiological role--state of the art].
Magnesium is an important intracellular cation which is known to participate in over 300 biochemical reactions of the cell. Most of the cell's Mg2+ is bound to intracellular structures, and only 5% of the total Mg2+ are unbound and thus biologically active. Clinical data concerning the therapeutic value of Mg2+ in various conditions like myocardial infarction are conflicting, experimental support for a specific therapy is still lacking, because values of free intracellular myocardial Mg2+ as well as behaviour of (Mg2+)i during ischemia or changes of extracellular ion-concentrations have not been elucidated as yet. Various techniques like Mg2+ sensitive dyes, nuclear magnetic resonance spectroscopy or Mg2+ selective microelectrodes have been employed, each of these techniques, however, harbours serious limitations.
Köppel
H
H
Klinischen Abteilung für Kardiologie der Medizinische Universätsklinik, Graz.
Gasser
R
R
Spichiger
U
U
D004396:Coloring Agents; D006321:Heart / Q000502:physiology*; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D008274:Magnesium / Q000032:analysis* / Q000378:metabolism / Q000502:physiology*; D009682:Magnetic Resonance Spectroscopy; D008839:Microelectrodes; D009206:Myocardium / Q000378:metabolism*
D004396:Coloring Agents; D007473:Ion Channels; D008274:Magnesium