title: Column asymmetric catalysis for beta-lactam synthesis.
abstract: [structure] A catalytic asymmetric reaction process was designed involving the use of solid-phase reagents and catalysts that constitute the packing of a series of "reaction columns". This process was applied to the catalytic asymmetric synthesis of beta-lactams, yielding pure product after crystallization with exceptional enantio- and diastereoselectivity.
authors: Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
authors: A M
authors: AM
authors: Hafez
authors: A E
authors: AE
authors: Taggi
authors: H
authors: H
authors: Wack
authors: W J
authors: WJ
authors: Drury
authors: T
authors: T
authors: Lectka
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002384:Catalysis; D003460:Crystallization; D008968:Molecular Conformation; D013237:Stereoisomerism; D047090:beta-Lactams
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams