[Hormone replacement therapy in menopause and colorectal disease].
Colorectal disease is frequent. Accumulating evidence indicates that postmenopausal hormone replacement therapy may reduce the risk of this pathology in women. Through MEDLINE computer searches, we identified English-language articles with quantitative data on the relation of postmenopausal hormone replacement therapy to colorectal cancers and adenoma. Twenty-four studies about colorectal cancer and five studies about colorectal adenoma were reviewed. Epidemiological data suggest a 20 to 30% reduced risk of colorectal cancer and adenoma among women taking postmenopausal hormones. There is biological evidence to support this association.
Sferlazzo
K
K
Service de Gynécologie-Obstétrique, Hôpital Nord, chemin des Bourrelys, 13015 Marseille.
Giusiano
B
B
D'ercole
C
C
Boubli
L
L
D015179:Colorectal Neoplasms / Q000517:prevention & control*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D017698:Postmenopause