title: Gangrene of the fingertips after bleomycin and methotrexate.
abstract: The increased use of cytostatic drugs, which are sometimes used in combination chemotherapy, may result in new and unusual cutaneous side effects. We describe a 57-year-old man with acral erythrocyanosis progressing to acute digital ischemia and gangrene that developed after combined chemotherapy (bleomycin and methotrexate) used to treat a metastatic squamous cell carcinoma of the hypopharynx. A leukocytoclastic vasculitis was found in both the acute phase and in the amputated fingertips. This supports the well-reported potential of bleomycin to trigger acral vascular toxicity.
authors: Department of Dermatology, Instituto Português de Oncologia, Porto, Portugal.
authors: O
authors: O
authors: Correia
authors: F
authors: F
authors: Ribas
authors: R
authors: R
authors: Azevedo
authors: H
authors: H
authors: Rodrigues
authors: L
authors: L
authors: Delgado
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001761:Bleomycin / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D003490:Cyanosis / Q000139:chemically induced; D005385:Fingers / Q000473:pathology*; D005734:Gangrene / Q000139:chemically induced*; D006801:Humans; D007511:Ischemia / Q000139:chemically induced; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000188:drug therapy
chemical_list: D001761:Bleomycin; D008727:Methotrexate