Tissue and blood levels of zinc, copper, and magnesium in nitric oxide synthase blockade-induced hypertension.
The aim of this study was to determine the levels of tissue and blood zinc (Zn), copper (Cu), magnesium (Mg) in nitric oxide (NO) synthase blockade-induced hypertension. A group of albino rats received a NO synthase inhibitor, N(G)-nitro-L-arginine-methyl ester (L-NAME, 60 mg/kg/d) in their drinking water for 21 d. L-NAME intake caused a progressive rise in this group's resting mean arterial blood pressure compared to a control group (p < 0.01). There were no differences between the groups with regard to tissue and blood levels of Zn or Cu; however, Mg concentrations were significantly lower in the hypertensive rats' erythrocytes (20.2% reduction from control levels), cerebral cortex (17.0%), heart (9.1%), renal cortex (12%), renal medulla (16.7%), and in the tissues of the caval vein (23.7%), mesenteric artery (29.8%), renal artery (18.4%), and renal vein (22.1%). There were no significant Mg concentration changes in the hypertensive group's plasma, cerebellum, liver, duodenum, or aortal tissue. These findings suggest that Mg depletion may play a role in the blood pressure rise that occurs in the model of chronic NO synthase inhibition-induced hypertension.
Sentürk
U K
UK
Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Kaputlu
I
I
Gündüz
F
F
Kuru
O
O
Gökalp
O
O
D000818:Animals; D003300:Copper / Q000032:analysis* / Q000097:blood; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D008274:Magnesium / Q000032:analysis* / Q000097:blood; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats; D015032:Zinc / Q000032:analysis* / Q000097:blood
D004791:Enzyme Inhibitors; D003300:Copper; D019001:Nitric Oxide Synthase; D008274:Magnesium; D015032:Zinc; D019331:NG-Nitroarginine Methyl Ester