title: Olfactory and trigeminal event-related potentials in migraine.
abstract: BACKGROUND
  Trigeminal/neuronal hyperexcitability and spreading depression activating the trigemino-vascular system are discussed in migraine-pathophysiology. This study investigated trigeminal and olfactory event-related potentials in migraineurs.
  
  
  METHODS
  Nasal chemosensitivity was assessed in 19 female migraineurs with or without aura > 72 h before or after an attack and in 19 healthy females employing event-related cortical potentials (ERPs) after specific trigeminal stimulation of nasal nociceptors with short pulses of CO2, and specific olfactory stimulation with H2S. Odour thresholds and odour identification performance were also tested.
  
  
  RESULTS
  Migraineurs exhibited greater responses to trigeminal stimulation, indicated by significantly larger ERP amplitudes N1. In contrast, olfactory ERP amplitudes P1N1 were significantly smaller in migraineurs. A leave-one-out classification procedure on the basis of these two parameters assigned 76.3% cases correctly. The olfactory ERP amplitude discriminated better between groups than trigeminal ERPs (71.1 vs. 68.4% correct classification).
  
  
  CONCLUSIONS
  Our data suggest trigeminal hyperexcitability in migraineurs. A general increase of nasal chemosensitivity is not supported because of smaller olfactory ERP amplitudes in migraineurs. Olfactory ERPs discriminate better than trigeminal ERPs between migraineurs and controls, emphasizing the significance of the olfactory system in migraine.
authors: Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nürnberg, Erlangen, Germany.
authors: K
authors: K
authors: Grosser
authors: R
authors: R
authors: Oelkers
authors: T
authors: T
authors: Hummel
authors: G
authors: G
authors: Geisslinger
authors: K
authors: K
authors: Brune
authors: G
authors: G
authors: Kobal
authors: J
authors: J
authors: Lötsch
mesh_terms: D000328:Adult; D002628:Chemoreceptor Cells / Q000503:physiopathology; D016002:Discriminant Analysis; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D008881:Migraine Disorders / Q000145:classification / Q000503:physiopathology*; D009832:Olfactory Nerve / Q000503:physiopathology*; D011601:Psychophysics / Q000379:methods; D012016:Reference Values; D014276:Trigeminal Nerve / Q000503:physiopathology*