Nitrofurantoin is active against vancomycin-resistant enterococci.
The activity of nitrofurantoin was tested against 300 isolates of Enterococcus faecium, Enterococcus faecalis, and Enterococcus gallinarum. No isolates tested were resistant to nitrofurantoin (MIC, >/=128 microg/ml), including vancomycin-resistant E. faecium isolates with vanA- and vanB-positive genotypes and vancomycin-resistant E. gallinarum isolates. We conclude that nitrofurantoin may provide effective treatment of urinary tract infections caused by vancomycin-resistant enterococci.
Zhanel
G G
GG
Departments of Clinical Microbiology and Medicine, Health Sciences Centre and Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada. ggzhanel@pcs.mb.ca
Hoban
D J
DJ
Karlowsky
J A
JA
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000378:metabolism; D019729:Carbon-Oxygen Ligases / Q000378:metabolism; D016983:Enterococcus / Q000187:drug effects* / Q000235:genetics; D005243:Feces / Q000382:microbiology; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D009582:Nitrofurantoin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance / Q000235:genetics*
D000900:Anti-Bacterial Agents; D000892:Anti-Infective Agents, Urinary; D001426:Bacterial Proteins; C071437:VanA ligase, Bacteria; D014640:Vancomycin; D009582:Nitrofurantoin; D019729:Carbon-Oxygen Ligases