Cardiac troponin I level correlates with chronic-phase left ventricular function after successful direct percutaneous transluminal coronary angioplasty in patients with acute myocardial infarction.
OBJECTIVE
The relationships between cardiac troponin I, various biochemical markers, and chronic-phase left ventricular ejection fraction (LVEF) after successful direct percutaneous transluminal coronary angioplasty (PTCA) were examined in 36 patients with acute myocardial infarction.


METHODS
Biochemical markers were measured on admission, immediately after, and from 6 hours to 9 days after PTCA.


RESULTS
The time to peak values were: creatine kinase-MB 9.7 hours, cardiac troponin I 9.8 hours, myoglobin 10.7 hours, creatine kinase 10.6 hours, cardiac troponin T 18.6 hours, and myosin light chain 68.9 hours. Cardiac troponin T, cardiac troponin I and myosin light chain levels were elevated over 9 days after successful direct PTCA. Chronic-phase LVEF inversely correlated with peak values of creatine kinase-MB (r = -0.519, p < 0.01), cardiac troponin T (r = -0.500, p < 0.01), cardiac troponin I (r = -0.441, p < 0.05) and creatine kinase (r = -0.411, p < 0.05). The values of cardiac troponin I, cardiac troponin T, creatine kinase and creatine kinase-MB at each sampling point were significantly inversely related to chronic-phase LVEF. The value of cardiac troponin I at each time point for 7 days correlated well with chronic-phase LVEF.


CONCLUSIONS
Cardiac troponin I has high specificity for predicting long-term cardiac function after successful direct PTCA when early values are unavailable.
Hara
S
S
Department of Medicine, Dokkyo University School of Medicine, Tochigi.
Horinaka
S
S
Tsuchiya
N
N
Yabe
A
A
Asakawa
H
H
Yagi
H
H
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009211:Myoglobin / Q000032:analysis; D018994:Myosin Light Chains / Q000097:blood; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood; D016277:Ventricular Function, Left
D015415:Biomarkers; D009211:Myoglobin; D018994:Myosin Light Chains; D019210:Troponin I; D020107:Troponin T; D003402:Creatine Kinase