title: Factor XIII deficiency and postoperative hemorrhage after neurosurgical procedures.
abstract: BACKGROUND
  Factor XIII is of physiological importance for hemostasis, especially in patients undergoing surgery. It catalyzes the enzymatic cross-linking of fibrin monomers into stable polymers and protects polymers from plasmatic and nonspecific degradation. Postoperative hemorrhage in patients with congenital and acquired Factor XIII deficiencies has been described in various surgical fields. However, there are no data about the incidence and clinical relevance of decreased Factor XIII after neurosurgical procedures. The objective of our study was to investigate the association between Factor XIII deficiency and postoperative hemorrhage after intracranial surgery.
  
  
  METHODS
  A total of 1264 patients who underwent intracranial operations were reviewed retrospectively. Standard coagulation parameters were monitored during the perioperative course in all patients. Factor XIII testing was performed postoperatively in 34 patients in whom coagulopathies were suspected despite normal platelets, fibrinogen, prothrombin, and partial thromboplastin time. Data were analyzed to evaluate the association of Factor XIII deficiency and major postoperative hemorrhage.
  
  
  RESULTS
  In this series of 1264 patients, a total of 20 patients (1. 6%) suffered from a major postoperative hemorrhage. Of the 34 patients with suspected coagulopathies and postoperative Factor XIII testing, 11 had a major postoperative hemorrhage. Normal levels of Factor XIII, defined as more than 60%, were found in 26 of the 34 patients. Factor XIII deficiency, defined as less than 60%, was found in eight patients. All patients with Factor XIII deficiency (n = 8) had a major postoperative hemorrhage. Of the remaining 26 patients with normal Factor XIII levels only three had a postoperative hemorrhage (p < 0.00001, Fisher's exact test).
  
  
  CONCLUSIONS
  Decreased Factor XIII activity may be associated with an increased risk of postoperative hemorrhage after intracranial surgery.
authors: Department of Neurosurgery, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany.
authors: R
authors: R
authors: Gerlach
authors: A
authors: A
authors: Raabe
authors: M
authors: M
authors: Zimmermann
authors: A
authors: A
authors: Siegemund
authors: V
authors: V
authors: Seifert
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000601:surgery*; D005177:Factor XIII Deficiency / Q000150:complications*; D005260:Female; D006406:Hematoma / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods*; D019106:Postoperative Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D013997:Time Factors; D014057:Tomography, X-Ray Computed