title: Bioactive triterpenoids from the stem bark of Picea glehni.
abstract: Two new triterpenoids, 3 alpha-methoxyserrat-14-en-21 beta-yl formate (1), and 24-methylcycloartenone (2), were isolated from the stem bark of Picea glehni (Fr. Schm.) Masters together with three known triterpenoids, 3 alpha-methoxyserrat-14-en-21 beta-ol, 3 beta-methoxyserrat-14-en-21 beta-ol, and piceanonol A. Compounds 1, 2, and a synthetic sample, 3 alpha-methoxyserrat-13-en-21 beta-yl formate showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).
authors: Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Japan. tanakar@oysun01.oups.ac.jp
authors: R
authors: R
authors: Tanaka
authors: Y
authors: Y
authors: Kinouchi
authors: H
authors: H
authors: Tokuda
authors: H
authors: H
authors: Nishino
authors: S
authors: S
authors: Matsunaga
mesh_terms: D000956:Antigens, Viral / Q000187:drug effects; D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D018547:Plant Stems / Q000737:chemistry; D014197:Trees / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C418726:24-methylcycloartenone; C418725:3-alpha-methoxyserrat-14-en-21-beta-yl formate; D000956:Antigens, Viral; D014315:Triterpenes