title: Design and synthesis of novel [60]fullerene derivatives as potential HIV aspartic protease inhibitors.
abstract: [structure] Two water-soluble fullerene derivatives have been computer-designed and synthesized. They may exhibit interesting anti-HIV activity owing to the presence of two ammonium groups strategically located on the spheroid surface.
authors: Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa, 1, 34127 Trieste, Italy.
authors: G L
authors: GL
authors: Marcorin
authors: T
authors: T
authors: Da Ros
authors: S
authors: S
authors: Castellano
authors: G
authors: G
authors: Stefancich
authors: I
authors: I
authors: Bonin
authors: S
authors: S
authors: Miertus
authors: M
authors: M
authors: Prato
mesh_terms: D002244:Carbon / Q000737:chemistry*; D015195:Drug Design; D037741:Fullerenes; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
chemical_list: D037741:Fullerenes; D017320:HIV Protease Inhibitors; D002244:Carbon; C069837:fullerene C60