title: Induction of polyomavirus-specific CD8(+) T lymphocytes by distinct dendritic cell subpopulations.
abstract: Dendritic cells are pivotal antigen-presenting cells for generating adaptive T-cell responses. Here, we show that dendritic cells belonging to either the myeloid-related or lymphoid-related subset are permissive for infection by mouse polyomavirus and, when loaded with a peptide corresponding to the immunodominant anti-polyomavirus CD8(+) T-cell epitope or infected by polyomavirus, are each capable of driving expansion of primary polyomavirus-specific CD8(+) T-cell responses in vivo.
authors: Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors: D R
authors: DR
authors: Drake
authors: M L
authors: ML
authors: Shawver
authors: A
authors: A
authors: Hadley
authors: E
authors: E
authors: Butz
authors: C
authors: C
authors: Maliszewski
authors: A E
authors: AE
authors: Lukacher
mesh_terms: D000818:Animals; D018845:CD11 Antigens / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016466:CHO Cells; D006224:Cricetinae; D003713:Dendritic Cells / Q000502:physiology*; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D011120:Polyomavirus / Q000276:immunology*
chemical_list: D018845:CD11 Antigens