Congenital hepatic fibrosis and cystic bile duct formation in Swiss Freiberger horses.
Congenital hepatic fibrosis with autosomal recessive or dominant inheritance has been described in humans, cats, piglets, and dogs. In horses, only two cases of congenital hepatic fibrosis have been previously reported. This retrospective study of records from the Institute for Animal Pathology, University of Berne, identified 30 foals with liver lesions compatible with congenital hepatic fibrosis. Anamnestic data revealed clinical signs of severe liver injury in most affected animals. Pathologic examination showed severely enlarged, firm livers with thin-walled cysts. Histologically, the livers showed diffuse porto-portal bridging fibrosis with many small, irregularly formed and sometimes cystic bile ducts. All foals belonged to the Swiss Freiberger breed. Pedigree analysis revealed that the diseased animals could be traced back to one stallion. These results strongly suggest that congenital hepatic fibrosis in Swiss Freiberger horses is a recessively inherited autosomal genetic defect.
Haechler
S
S
Institut für Tierpathologie, Universität Bern, Switzerland.
Van den Ingh
T S
TS
Rogivue
C
C
Ehrensperger
F
F
Welle
M
M
D000818:Animals; D001649:Bile Duct Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D003549:Cystic Duct / Q000473:pathology*; D005260:Female; D006734:Horse Diseases / Q000151:congenital / Q000235:genetics / Q000473:pathology*; D006736:Horses; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000151:congenital / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010375:Pedigree; D012189:Retrospective Studies