title: De novo muscle invasive bladder cancer: is there a change in trend?
abstract: OBJECTIVE
  We reviewed our radical cystectomy series to determine whether the majority of patients present with muscle invasive bladder cancer.
  
  
  METHODS
  The records of 184 radical cystectomies performed by 1 surgeon from 1992 to 1999 were reviewed, and all slides of presenting pathology were reviewed by 1 pathologist. The pathological stage of the tumor at presentation was noted in each case, and the number of muscle invasive tumors at presentation was compared to 2 earlier series.
  
  
  RESULTS
  Radical cystectomy was performed for muscle invasive transitional cell carcinoma of the bladder in 176 cases and for other histology in 8. There were 101 (57.3%) patients with muscle invasive cancer at presentation compared to 84% and 91% in the 2 earlier series, respectively, which was a statistically significant decrease (p <0. 0001) in the number of de novo muscle invasive bladder cancers. Women were more likely to be diagnosed with muscle invasion primarily than men (85.2% and 50.7%, respectively), and younger patients (younger than 50 years) were more likely to present with superficial bladder cancer compared to those older than 50 years who were more likely to present with de novo muscle invasive bladder cancer.
  
  
  CONCLUSIONS
  Analysis of our data supports the findings of the earlier series that the majority of patients present with muscle invasive bladder cancer. However, there is a significant decrease in the percentage of tumors invading the muscularis propria at presentation. Although this observation is encouraging, we emphasize that it is not as dramatic as the stage migration associated with prostate cancer, which may be largely attributed to the widespread use of prostate specific antigen for early detection. Therefore, we support the suggestion that therapeutic gains might follow from improved education regarding the signs and symptoms associated with bladder cancer, with enhanced focus on women and consideration of screening methods for those at high risk for bladder cancer.
authors: Departments of Urology and Pathology, University of Miami, Miami, Florida, USA.
authors: A
authors: A
authors: Vaidya
authors: M S
authors: MS
authors: Soloway
authors: C
authors: C
authors: Hawke
authors: R
authors: R
authors: Tiguert
authors: F
authors: F
authors: Civantos
mesh_terms: D000368:Aged; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D002295:Carcinoma, Transitional Cell / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D015653:Cystectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D009361:Neoplasm Invasiveness; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery