Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'.
Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction.
Prakken
B
B
Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0663, USA.
Wauben
M
M
Genini
D
D
Samodal
R
R
Barnett
J
J
Mendivil
A
A
Leoni
L
L
Albani
S
S
D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000008:administration & dosage*; D007108:Immune Tolerance; D007158:Immunologic Techniques; D008081:Liposomes; D010455:Peptides / Q000008:administration & dosage*; D014611:Vaccination / Q000379:methods
D000949:Histocompatibility Antigens Class II; D008081:Liposomes; D010455:Peptides