Genetic imprinting: silencing elements have their say.
Tissue-specific silencing elements have been identified that are required for imprinting of the individual genes in the Igf2-H19 domain of the mouse genome. These elements further elaborate the differences between the two parental chromosomes, and add a new feature to parent-of-origin-specific gene regulatory complexes.
Ferguson-Smith
A C
AC
Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY,., Cambridge, UK. afsmith@mole.bio.cam.ac.uk
D000818:Animals; D020868:Gene Silencing; D016678:Genome; D018392:Genomic Imprinting; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D051379:Mice; D008957:Models, Genetic; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics*
C094335:H19 long non-coding RNA; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D007335:Insulin-Like Growth Factor II