Molecular weight dependency on the production of the TNF stimulated by fractions of rye (1-->3),(1-->4)-beta-D-glucan.
Mixed-linkage (1-->3),(1-->4)-beta-D-glucan with a weight average molecular weight varying between 79,800 and 13,900 was purified from rye. These fractions were used for stimulation of human monocytes to produce tumour necrosis factor (TNF). A mixed-linkage beta-glucan with a weight average molecular weight of 18,900 was found to be the most potent immunostimulator.
Roubroeks
J P
JP
Department of Food Science, Swedish University of Agricultural Sciences, PO Box 7051, SE-750 07 Uppsala, Sweden. Hanno.Roubroecks@lmv.slu.se
Skjåk-Braek
G
G
Ryan
L
L
Christensen
B E
BE
D005936:Glucans / Q000276:immunology*; D006801:Humans; D008970:Molecular Weight; D009000:Monocytes / Q000276:immunology*; D012434:Secale; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D047071:beta-Glucans
D005936:Glucans; D014409:Tumor Necrosis Factor-alpha; D047071:beta-Glucans; C067858:beta-glucan, (1-3)(1-4)-