title: Neuroendocrine effects of progesterone.
abstract: Progesterone (P) is secreted by the corpus luteum under the control of gonadotropin releasing hormone (GnRH)/luteinizing hormone (LH). Progesterone (P) is essential for reproduction because: (1) it induces in the endometrium the transcription of specific genes involved in the implantation of the blastocyst, (2) it modulates GnRH/LH secretion by decreasing GnRH pulse frequency, which in turn enriches the gonadotroph cells in FSH and avoids a second LH surge. Using the ewe as a model, we investigated the immediate GnRH and LH responses to acute changes of circulating P levels. Our results show that P changes cause dramatic modifications in GnRH pulse frequency: P removal induces an acceleration of the pulse generator, while P administration slows the pulse frequency. LH secretion was modified in parallel to the changes in GnRH. Other experiments proved that these neuroendocrine effects of P are mediated by P itself, not by its hydroxylated metabolites, and occur at the level of P receptors. Finally, these effects require priming by estradiol. Additionally, in the final stage of the follicular phase, P plays a role in the triggering of the LH surge. This has been shown in rodents, non-human primates, and in women. Such a phenomenon is not observed in ewes, although in these species luteal P modulates the amplitude of the estradiol-induced LH surge.
authors: Service d'Endocrinologie, Hopital St Antoine, 184 rue du Faubourg Saint Antoine, Paris, France. nathalie.chabbert-buffet@sat.ap-hop-paris.fr
authors: N
authors: N
authors: Chabbert-Buffeta
authors: D C
authors: DC
authors: Skinner
authors: A
authors: A
authors: Caraty
authors: P
authors: P
authors: Bouchard
mesh_terms: D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000187:drug effects; D009490:Neurosecretory Systems / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology* / Q000502:physiology; D011963:Receptors, GABA-A / Q000502:physiology
chemical_list: D011963:Receptors, GABA-A; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D007986:Luteinizing Hormone