The ALG-2/AIP-complex, a modulator at the interface between cell proliferation and cell death? A hypothesis.
During the development of an organism cell proliferation, differentiation and cell death are tightly balanced, and are controlled by a number of different regulators. Alterations in this balance are often observed in a variety of human diseases. The role of Ca(2+) as one of the key regulators of the cell is discussed with respect to two recently discovered proteins, ALG-2 and AIP, of which the former is a Ca(2+)-binding protein, and the latter is substrate to various kinases. The two proteins interact with each other in a Ca(2+)-dependent manner, and the role of the complex ALG-2/AIP as a possible modulator at the interface between cell proliferation and cell death is discussed.
Krebs
J
J
Institute of Biochemistry, Swiss Federal Institute of Technology, Zurich, Switzerland. krebs@bc.biol.ethz.ch
Klemenz
R
R
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D019556:COS Cells; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D002135:Calcium-Binding Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins; D002454:Cell Differentiation; D002455:Cell Division; D016384:Consensus Sequence; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D056827:Endosomal Sorting Complexes Required for Transport; D006801:Humans; D007150:Immunohistochemistry; D008956:Models, Chemical; D008969:Molecular Sequence Data; D056465:Retinoblastoma-Binding Protein 1; D016415:Sequence Alignment; D050680:Transcription Factor DP1; D014157:Transcription Factors / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D056827:Endosomal Sorting Complexes Required for Transport; C097753:PDCD6 protein, human; C117020:PDCD6IP protein, human; D056465:Retinoblastoma-Binding Protein 1; D050680:Transcription Factor DP1; D014157:Transcription Factors; D002118:Calcium