Support for an association between HLA-DR1 and schizophrenia in the Japanese population.
An increase of HLA-DR1 has been observed in schizophrenia patients from the Japanese population. A decrease of DR4, which was reported in Caucasian patients, has also been found in some of the Japanese studies. This small study further investigated frequencies of HLA-DR1 and DR4 in unrelated Japanese patients with schizophrenia (n = 45) and healthy comparison subjects (n = 117). The number of patients possessing DR1 was higher (10 of 45, 22%) compared with the comparison group (11 of 117, 9.4%, P = 0.03). This may support the previous observation of an increased DR1 frequency in the Japanese patients. When the present data is combined with three previous studies, proportions of the Japanese subjects with DR1 were 98 of 588 schizophrenia patients (16.7%) vs. 93 of 942 comparison subjects (9.9%). However, no difference was observed in DR4 frequencies between the patients (51%) and comparison subjects (44%). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:725-727, 2000.
Akaho
R
R
Section of Mental Health, Health Service Center, University of Tokyo, Tokyo, Japan.
Matsushita
I
I
Narita
K
K
Okazaki
Y
Y
Okabe
Y
Y
Matsushita
M
M
Hohjoh
H
H
Tokunaga
K
K
Sasaki
T
T
D000328:Adult; D005260:Female; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics; D015798:HLA-DR1 Antigen / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics*
D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D059811:HLA-DRB1 Chains