A capillary whole blood method for measuring the INR.
This study describes a method of measuring the INR on native whole blood capillary samples using Innovin recombinant thromboplastin. Modification of the reagent was necessary to compensate for the nonoptimal level of calcium in the sample/reagent mixture. Ninety-five percent of results obtained by the capillary blood method were no more than 0.42 INR higher or 0.38 INR lower than the venous blood method. The effect of changes in haematocrit was minimal. Significant differences in results were found between the Innovin and Thrombotest capillary blood methods. Provided the reagent was properly stored, there was no reagent drift and satisfactory results were obtained on samples supplied by UKNEQAS (coagulation) from previous trials. The method described is a convenient, simple and accurate method of measuring the INR using native capillary whole blood and Innovin recombinant thromboplastin.
Bamford
E J
EJ
Haematology Department, Neath General Hospital, Pant yr Heol, Neath, UK.
Bowen
R H
RH
Broad
J P
JP
Hawken
A
A
Morgan
J
J
Owen
C L
CL
Powell
L
L
Sullivan
B C
BC
Tollick
H
H
Wakeman
L
L
Lewis
M S
MS
Beddall
A C
AC
D001780:Blood Coagulation Tests / Q000379:methods* / Q000592:standards; D001800:Blood Specimen Collection / Q000379:methods; D002196:Capillaries; D006400:Hematocrit; D006801:Humans; D019934:International Normalized Ratio; D011517:Prothrombin Time; D012015:Reference Standards; D015203:Reproducibility of Results