[Effects of rumalon and arteparon correcting metabolism in the connective tissue on the functional state of the liver in toxic hepatitis].
Effects of the connective tissue metabolism correctors rumalon (a glycosaminoglycane peptide complex) and arteparon (glucosamine sulfate) on the cholepoietic and absorption-excretion functions of liver were studied on a model of toxic liver damage. Rumalon exhibits pronounced anticholelithiasis and cholagogic properties and improves the absorption-excretion liver function. Arteparon produced no cholagogic action, inhibited the elimination of bromosulfalein, and showed no anticholelithiasis activity. The difference in the pharmacological effects of two drugs is related to their structural distinctions and the differing characteristics of aglycons and anions entering into their compositions.
Misiureva
S V
SV
Clinical Pharmacy Department, Ukrainian Pharmaceutical Academy, Kharkov, Ukraine.
Zupanets
I A
IA
D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000503:physiopathology; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D020355:Cholates / Q000032:analysis; D002784:Cholesterol / Q000032:analysis; D000431:Ethanol; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D007202:Indicators and Reagents; D008099:Liver / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013448:Sulfobromophthalein; D014020:Tissue Extracts / Q000627:therapeutic use*
D002756:Cholagogues and Choleretics; D020355:Cholates; D006025:Glycosaminoglycans; D007202:Indicators and Reagents; D014020:Tissue Extracts; D013448:Sulfobromophthalein; C000562:Rumalon; D000431:Ethanol; C010034:Arteparon; D002784:Cholesterol