RNA polymerase: structural similarities between bacterial RNA polymerase and eukaryotic RNA polymerase II.
Bacterial RNA polymerase and eukaryotic RNA polymerase II exhibit striking structural similarities, including similarities in overall structure, relative positions of subunits, relative positions of functional determinants, and structures and folding topologies of subunits. These structural similarities are paralleled by similarities in mechanisms of interaction with DNA.
Ebright
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Howard Hughes Medical Institute, Waksman Institute and Department of Chemistry Rutgers University, Piscataway, NJ 08854, USA. ebright@mbcl.rutgers.edu
D000818:Animals; D001419:Bacteria / Q000201:enzymology*; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000235:genetics / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry* / Q000378:metabolism; D005057:Eukaryotic Cells / Q000201:enzymology*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D021122:Protein Subunits; D012319:RNA Polymerase II / Q000737:chemistry* / Q000378:metabolism
D021122:Protein Subunits; D004247:DNA; D012319:RNA Polymerase II; D012321:DNA-Directed RNA Polymerases