title: Which patients with newly diagnosed prostate cancer need a radionuclide bone scan? An analysis based on 631 patients.
abstract: OBJECTIVE
  Although radionuclide bone scans are frequently recommended as part of the staging evaluation for newly diagnosed prostate cancer, most scans are negative for metastases. We hypothesized that Gleason score, prostate-specific antigen (PSA), and clinical stage could predict for a positive bone scan (BS), and that a low-risk group of patients could be identified in whom BS might be omitted.
  
  
  METHODS
  All patients who had both pathologic review of their prostate cancer biopsies and radionuclide BS at our institution between 1/90 and 5/96 were studied. Gleason score, PSA, and clinical stage (AJCC, 4th edition) were evaluated by univariate and multivariate analyses for their ability to predict a positive BS. Groups analyzed were Gleason of 2-6 vs. 7 vs. 8-10; PSA of 0-15 vs. greater than 15-50 vs. greater than 50; and clinical stage of T1a-T2b vs. T2c-T4. Univariate analysis using chi(2) and multivariate analysis using logistic regression were performed.
  
  
  RESULTS
  Of the 631 consecutive patients, 88 (14%) had positive BS. Multivariate analysis (64 excluded due to missing PSA and/or clinical stage) showed Gleason score, PSA, and clinical stage to be significant independent predictors for positive BS (p < 0.002, p < 0.001, p < 0.001, respectively). The odds ratios were 5.25 (confidence interval [CI], 3.43-8.04) for PSA > 50 vs. 0-15; 2.25 (CI, 1.43-3.54) for Gleason of 8-10 vs. 2-6; 2.15 (CI, 1.54-2.99) for clinical stage T2c-T4 vs. T2b or less. Three of 308 (1%) had a positive BS in patients with Gleason 2-7, PSA of 50 or less, and clinical stage of T2b or less. In the subset of the same risk group with PSA of 15 or less, all 237 had negative bone scans. In patients with PSA greater than 50, 49/99(49.5%) had positive BS.
  
  
  CONCLUSIONS
  Gleason score, PSA, and clinical stage were independent predictors for a positive radionuclide BS in newly diagnosed prostate cancer patients. PSA is the major predictor for positive BS. About one-half of the patients analyzed were in the low-risk group (Gleason 2-7, PSA < or = 50, clinical stage < or = T2b) and elimination of BS in these patients would result in considerable economic savings.
authors: Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
authors: N
authors: N
authors: Lee
authors: R
authors: R
authors: Fawaaz
authors: C A
authors: CA
authors: Olsson
authors: M C
authors: MC
authors: Benson
authors: D P
authors: DP
authors: Petrylak
authors: P B
authors: PB
authors: Schiff
authors: E
authors: E
authors: Bagiella
authors: A
authors: A
authors: Singh
authors: R D
authors: RD
authors: Ennis
mesh_terms: D000704:Analysis of Variance; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D006801:Humans; D016015:Logistic Models; D008297:Male; D009367:Neoplasm Staging; D016017:Odds Ratio; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging
chemical_list: D017430:Prostate-Specific Antigen