Column asymmetric catalysis for beta-lactam synthesis.
[structure] A catalytic asymmetric reaction process was designed involving the use of solid-phase reagents and catalysts that constitute the packing of a series of "reaction columns". This process was applied to the catalytic asymmetric synthesis of beta-lactams, yielding pure product after crystallization with exceptional enantio- and diastereoselectivity.
Hafez
A M
AM
Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
Taggi
A E
AE
Wack
H
H
Drury
W J
WJ
Lectka
T
T
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002384:Catalysis; D003460:Crystallization; D008968:Molecular Conformation; D013237:Stereoisomerism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams