title: Clinicopathological features of long-term survivors of scirrhous gastric cancer.
abstract: OBJECTIVE
  Prognosis of scirrhous gastric cancer remains low. To determine the clinicopathological features that are correlated with prognosis, we studied long-term survivors of scirrhous gastric cancer (survival duration more than 5 years) in comparison with patients with short survival.
  
  
  METHODS
  Among 2719 gastric cancer patients who underwent surgery at Matsuyama Red Cross Hospital, 211 cases were diagnosed as scirrhous type gastric cancer. Seventeen patients survived more than 5 years, and the rest had short survival (less than 5 years). Comparison of clinicopathological factors was done by chi 2 analysis. Multivariate analysis was done in order to focus on the prognostic factors.
  
  
  RESULTS
  The 5-year survival of the total 211 patients was 12%. The 5-year survival of patients who underwent curative surgery (67 cases) was 30%, which was significantly higher than that of the non-curative surgery group (144 cases, 6%). Significant differences were noted in the following variables: peritoneal dissemination, hepatic metastasis, lymph node dissection, pattern of infiltrating growth, depth of invasion, histological lymph node metastasis, histological stage, and histological curability. Patients with either hepatic metastasis or peritoneal dissemination did not survive 5 years. Multivariate analysis revealed that the most significant independent prognostic factor was histological curability, followed by peritoneal dissemination.
  
  
  CONCLUSIONS
  There is a possibility of long-term survival for patients with scirrhous gastric cancers without hepatic metastasis, peritoneal dissemination, or extensive lymph node metastasis. Curative surgery is important, suggesting that the extended operation is rational if possible.
authors: Department of Surgery, Matsuyama Red Cross Hospital, Japan.
authors: I
authors: I
authors: Takahashi
authors: T
authors: T
authors: Matsusaka
authors: T
authors: T
authors: Onohara
authors: T
authors: T
authors: Nishizaki
authors: T
authors: T
authors: Ishikawa
authors: H
authors: H
authors: Tashiro
authors: K
authors: K
authors: Wakasugi
authors: K
authors: K
authors: Kume
authors: Y
authors: Y
authors: Maehara
authors: K
authors: K
authors: Sugimachi
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate