Basic mechanisms of stroke prevention with lipid-lowering therapy.
Cholesterol-lowering therapy has not been considered an important risk factor for stroke; however, lipid-lowering therapies reduce cerebrovascular events in patients with coronary heart disease (CHD). The basic mechanisms of cerebrovascular protection have emphasized reduced atheroemboli from the left ventricle and aortic arch, delayed carotid artery disease progression, stabilization of vulnerable carotid atherosclerotic plaque, and improvement in cerebral blood flow.
Rosenson
R S
RS
Preventive Cardiology Center, Rush-Presbyterian-St. Luke"s Medical Center, 1725 West Harrison Street, Suite 1159, Chicago, IL 60612, USA. rrosenso@rush.edu
D002340:Carotid Artery Diseases / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology; D017700:Embolism, Cholesterol / Q000503:physiopathology; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control*
D000960:Hypolipidemic Agents