The rhamnose pathway.
L-Rhamnose is a deoxy sugar found widely in bacteria and plants. Evidence continues to emerge about its essential role in many pathogenic bacteria. The crystal structures of two of the four enzymes involved in its biosynthetic pathway have been reported and the other two have been submitted for publication. This pathway does not exist in humans, making enzymes of this pathway very attractive targets for therapeutic intervention.
Giraud
M F
MF
Institut de Biochimie et de Génétique Cellulaires du CNRS, Université Victor Segalen, Bordeaux 2, 1 rue Camille Saint-Saëns, F-33 077 cedex, Bordeaux, France.
Naismith
J H
JH
D018360:Crystallography, X-Ray; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D012210:Rhamnose / Q000096:biosynthesis / Q000378:metabolism*
D004798:Enzymes; D012210:Rhamnose