Enantioseparations using cellulose tris(3,5-dichlorophenylcarbamate) during high-performance liquid chromatography with analytical and capillary columns: potential for screening of chiral compounds.
The appropriate selection of the mobile phase facilitated the use cellulose tris(3,5-dichlorophenylcarbamate (CDCPC) as a chiral stationary phase (CSP) during high-performance liquid chromatography (HPLC). A preliminary evaluations of this material indicated its very high chiral resolving ability toward many analytes of different chemical and pharmacological groups. Some chemicals and drugs containing two centers of chirality were also successfully resolved into all possible stereoisomers. The applicability of CDCPC for enantioseparations in capillary liquid chromatography was also shown giving promising prospects for the screening of novel biologically active compounds (which may be also synthesized based on combinatorial strategies) for their enantiomeric composition.
Chankvetadze
B
B
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa-ku, 464-8603, Nagoya, Japan.
Yamamoto
C
C
Okamoto
Y
Y
D002219:Carbamates; D002482:Cellulose / Q000031:analogs & derivatives*; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D007202:Indicators and Reagents; D048448:Phenylcarbamates; D013237:Stereoisomerism
D002219:Carbamates; D007202:Indicators and Reagents; D048448:Phenylcarbamates; C420325:cellulose tris(3,5-dichlorophenylcarbamate); D002482:Cellulose