Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains.
From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.
Gingles
N A
NA
Department of Microbiology and Immunology, University of Leicester, Alderley Edge, United Kingdom.
Alexander
J E
JE
Kadioglu
A
A
Andrew
P W
PW
Kerr
A
A
Mitchell
T J
TJ
Hopes
E
E
Denny
P
P
Brown
S
S
Jones
H B
HB
Little
S
S
Booth
G C
GC
McPheat
W L
WL
D000818:Animals; D016470:Bacteremia / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006183:H-2 Antigens / Q000235:genetics; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009504:Neutrophils / Q000276:immunology; D011008:Pneumococcal Infections / Q000235:genetics / Q000276:immunology*; D013045:Species Specificity
D006183:H-2 Antigens