Successful pregnancy and birth after sequential cotreatment with growth hormone and gonadotropins in a woman with panhypopituitarism: a new treatment protocol.
OBJECTIVE
To report a successful pregnancy in a woman with panhypopituitarism who received 3 months of pretreatment with growth hormone (GH) before ovulation induction. Prior attempts at ovulation induction had failed for this patient.


METHODS
Case report.


METHODS
Department of Endocrinology.


METHODS
A 32-year-old woman with panhypopituitarism and secondary infertility.


METHODS
GH (1 IU/day) alone for 3 months; during the next cycle, 1 IU/day of GH; 3 ampules of hMG per day during days 1-21; 1 ampule of hCG on day 21. GH was discontinued on day 35 when a pregnancy test was positive.


METHODS
Pregnancy and delivery.


RESULTS
Pregnancy and birth of a normal child after a single ovulation stimulation using GH and gonadotropins.


CONCLUSIONS
This case report suggests interest in a new protocol for follicular stimulation in women with hypopituitarism who are responding poorly to gonadotropin therapy.
Salle
A
A
Department of Endocrinology, Centre Hospitalier Universitaire de Nancy, Vandoeuvre, France.
Klein
M
M
Pascal-Vigneron
V
V
Dousset
B
B
Leclere
J
J
Weryha
G
G
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000150:complications / Q000188:drug therapy*; D007231:Infant, Newborn; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D007743:Labor, Obstetric; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D011247:Pregnancy
D006063:Chorionic Gonadotropin; D019382:Human Growth Hormone; D008596:Menotropins