The tumour necrosis factor receptor family: life or death choices.
The past twelve months have seen a renewal of interest in the therapeutic potential of members of the tumour necrosis factor receptor family and their cytokine ligands. This biomedical interest has spawned a number of structural studies, which have significantly deepened our understanding of the molecular basis for the function of these cell-surface signalling systems. The fresh data have revealed unexpected mechanisms conferring ligand-receptor specificity and have highlighted the structural requirements for the initiation of intracellular signalling.
Jones
E Y
EY
CRC Receptor Structure Group, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, OX3 7BN, Oxford, UK. Yvonne.Jones@strubi.ox.ac.uk
D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction
D008024:Ligands; D018124:Receptors, Tumor Necrosis Factor