title: Unilateral glaucoma in Sotos syndrome (cerebral gigantism).
abstract: OBJECTIVE
  To report a patient with unilateral glaucoma associated with Sotos syndrome. Sotos syndrome (cerebral gigantism) is a disorder of growth and development with characteristic facial changes and normal endocrine function. Ocular manifestations may also include megalocornea, iris hypoplasia, cataracts, megalophthalmos, strabismus, nystagmus, and retinal dystrophy.
  
  
  METHODS
  Case report. A 50 year-old man with the clinical features of Sotos syndrome presented with complaints of decreased vision in the left eye.
  
  
  RESULTS
  Ophthalmologic examination revealed bilateral megalocornea, megalophthalmos, iris hypoplasia and transillumination defects, cataracts, and unilateral glaucoma. Intraocular pressure was lowered, and visual field loss was stabilized with topical medications.
  
  
  CONCLUSIONS
  Sotos syndrome patients should be examined routinely to allow for early detection and treatment of potential ocular problems, including glaucoma.
authors: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA. dryen@prodigy.net
authors: M T
authors: MT
authors: Yen
authors: S J
authors: SJ
authors: Gedde
authors: J T
authors: JT
authors: Flynn
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000002:abnormalities*; D002386:Cataract / Q000209:etiology; D003315:Cornea / Q000002:abnormalities / Q000473:pathology; D005124:Eye Abnormalities / Q000209:etiology* / Q000473:pathology; D005877:Gigantism / Q000150:complications*; D005901:Glaucoma / Q000209:etiology*; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000002:abnormalities / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014794:Visual Fields