Enzymatic oxidant and antioxidants of human blood platelets in unstable angina and myocardial infarction.
In ischaemic heart conditions we report a remarkable increase in platelet xanthine oxidase activity and rise in the levels of malondialdehyde (MDA) with concomitant decrease in the activities of free radical scavenging enzymes - superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. The increased levels of free radical generating system and MDA and lowered levels of free radical scavenging systems seem to have critical role in ischaemic heart conditions.
Pandey
N R
NR
Department of Biochemistry, Lucknow University, 226 007, Lucknow, India.
Kaur
G
G
Chandra
M
M
Sanwal
G G
GG
Misra
M K
MK
D000789:Angina, Unstable / Q000097:blood / Q000201:enzymology*; D000975:Antioxidants / Q000378:metabolism*; D001792:Blood Platelets / Q000201:enzymology*; D001798:Blood Proteins / Q000378:metabolism; D002374:Catalase / Q000097:blood; D005609:Free Radicals / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
D000975:Antioxidants; D001798:Blood Proteins; D005609:Free Radicals; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D005980:Glutathione Reductase