title: Randomized, controlled study of low-dose 5-fluorouracil in primary trabeculectomy.
abstract: OBJECTIVE
  To report a randomized clinical trial of postoperative subconjunctival injections of low-dose 5-fluorouracil in patients undergoing primary trabeculectomy.
  
  
  METHODS
  In a prospective, randomized clinical trial, 40 eyes of 40 patients were randomized to the low-dose 5-fluorouracil group and received three subconjunctival injections of 5 mg each over 11 postoperative days, and 40 eyes of 40 patients were randomized to trabeculectomy without 5-fluorouracil.
  
  
  RESULTS
  Mean (+/-SD) preoperative and 1-year postoperative intraocular pressures in the 5-fluorouracil group were 26.9 (+/-9.5) and 15.3 (+/-5.8) mm Hg, respectively. In the control group these were 25.9 (+/-8.1) mm Hg, and 15.8 (+/-5.1) mm Hg, respectively. The patients who received 5-fluorouracil had a mean reduction in intraocular pressure of 11.5 (+/-9.1) mm Hg at a median follow-up of 52.3 weeks. The control group had a mean reduction in intraocular pressure of 10.2 (+/-8.7) mm Hg at a median follow-up of 52.6 weeks. These differences were not statistically significant.
  
  
  CONCLUSIONS
  Three postoperative subconjunctival 5-fluorouracil injections of 5 mg each after trabeculectomy in eyes at low risk for failure had no statistically or clinically significant effect on reduction of intraocular pressure with 1-year follow-up. Enhancement of success in this group of patients may require a larger total dose of 5-fluorouracil.
authors: Department of Ophthalmology and Visual Sciences, Yale University School of Medicine and Yale-New Haven Hospital, New Haven, Connecticut, USA.
authors: I A
authors: IA
authors: Chaudhry
authors: M A
authors: MA
authors: Pasha
authors: D J
authors: DJ
authors: O'Connor
authors: M L
authors: ML
authors: Weitzman
authors: J
authors: J
authors: Caprioli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000963:Antimetabolites / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D003228:Conjunctiva; D004341:Drug Evaluation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D014130:Trabeculectomy; D016896:Treatment Outcome
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil