Cerebral blood flow and oxygen metabolism during mild hypothermia in patients with subarachnoid haemorrhage.
Cerebral blood flow and O2 metabolism during hypothermia (33-34 degrees C) was evaluated in 5 patients with aneurysmal subarachnoid haemorrhage by positron emission tomography (PET). Their preoperative clinical condition was WFNS scale IV or V. The patients received surface cooling postoperatively, and were maintained in a hypothermic state during transfer for radiological examination. Positron emission tomography revealed a decrease in cerebral blood flow and O2 metabolic rate. Cerebral blood flow was 34.8+/-15.1 ml/100 ml/min and the O2 metabolic rate was 1.85+/-0.61 ml/100 ml/min in areas of the middle cerebral artery ipsilateral to the ruptured aneurysms, whereas these values were 30.8+/-7.1 and 2.21+/-0.45 ml/100 ml/min, respectively, on the contralateral side. This represents a decrease of 37+/-27% compared to normal cerebral blood flow and 52+/-16% compared to normal O2 metabolic rate (p < 0.02) in the ipsilateral areas, and decreases of 44+/-13% and 43+/-12%, respectively, on the contralateral side. The present results reflected the luxury perfusion state in almost all cases and provide the first PET evidence of decreased cerebral blood flow and metabolic rate of O2 during hypothermia in humans.
Kawamura
S
S
Department of Strokology, Research Institute for Brain and Blood Vessels-AKITA, Japan.
Suzuki
A
A
Hadeishi
H
H
Yasui
N
N
Hatazawa
J
J
D000328:Adult; D000368:Aged; D002540:Cerebral Cortex / Q000098:blood supply* / Q000502:physiology; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D012039:Regional Blood Flow; D013345:Subarachnoid Hemorrhage / Q000628:therapy*; D014055:Tomography, Emission-Computed
D010100:Oxygen