A natural history of melanoma: serial gene expression analysis.
Ena Wang and Francesco Marincola propose a novel strategy whereby tumor-host interactions are studied within the melanoma microenvironment by serial gene expression analysis. Methodological constraints and ways to circumvent them are discussed. This approach might improve our understanding of the molecular basis of tumor regression in response to immune manipulation.
Wang
E
E
Dept of Transfusion Medicine, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1502, USA.
Marincola
F M
FM
D000483:Alleles; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D001707:Biopsy, Needle; D004273:DNA, Neoplasm / Q000235:genetics; D018450:Disease Progression; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016045:Human Genome Project; D006801:Humans; D007108:Immune Tolerance; D008545:Melanoma / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D020411:Oligonucleotide Array Sequence Analysis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000951:Antigens, Neoplasm; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins