Oncogene mutation and prognosis in the myelodysplastic syndromes.
In a series of myelodysplastic syndrome patients, mutational status (particularly RAS mutation) was found to be prognostic for survival, independently of four previously reported scoring systems (Bournemouth, Sanz, Lille, International).
Padua
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University of Wales College of Medicine, Heath Park, Cardiff, UK.
West
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D000367:Age Factors; D000753:Anemia, Refractory / Q000235:genetics; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics; D000756:Anemia, Sideroblastic / Q000235:genetics; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics; D009154:Mutation; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models