Hemispheric function in disorganized type schizophrenia: performance on the quality extinction test.
We assessed hemisphere function in right-handed male chronic, disorganized type schizophrenic patients (N = 60, age range 18-45 years) using the Quality Extinction Test (QET), in comparison to 20 right-handed male healthy controls in the same age range. The QET analysis discriminated between the disorganized schizophrenic patients and the controls. QET results indicated that chronic schizophrenic patients were less sensitive to tactile stimuli in both hands as compared to controls. Furthermore, the sensitivity to tactile stimuli of the left hand was less than that of the right hand in the schizophrenic patients. In contrast, in the normal controls the sensitivity was similar in both hands. These results indicate possible right hemisphere dysfunction together with disturbance in interhemispheric transmission through the corpus callosum in chronic, disorganized type schizophrenic patients.
Spivak
B
B
Research Unit, Ness Ziona Health Center, Ness Ziona, Israel.
Elimelech
D
D
Ocring
R
R
Mester
R
R
Kotler
M
M
Weizman
A
A
D000293:Adolescent; D000328:Adult; D003337:Corpus Callosum / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012562:Schizophrenia, Disorganized / Q000503:physiopathology* / Q000523:psychology; D012684:Sensory Thresholds / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D014110:Touch / Q000502:physiology