title: Acute marijuana effects on rCBF and cognition: a PET study.
abstract: The effects of smoking marijuana on cognition and brain function were assessed with PET using H2(15)O. Regional cerebral blood flow (rCBF) was measured in five recreational users before and after smoking a marijuana cigarette, as they repeatedly performed an auditory attention task. Blood flow increased following smoking in a number of paralimbic brain regions (e.g. orbital frontal lobes, insula, temporal poles) and in anterior cingulate and cerebellum. Large reductions in rCBF were observed in temporal lobe regions that are sensitive to auditory attention effects. Brain regions showing increased rCBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortices may account for the impaired cognitive functions associated with acute intoxication.
authors: Mental Health Clinical Research Center, University of Iowa, Iowa City 52242, USA.
authors: D S
authors: DS
authors: O'Leary
authors: R I
authors: RI
authors: Block
authors: M
authors: M
authors: Flaum
authors: S K
authors: SK
authors: Schultz
authors: L L
authors: LL
authors: Boles Ponto
authors: G L
authors: GL
authors: Watkins
authors: R R
authors: RR
authors: Hurtig
authors: N C
authors: NC
authors: Andreasen
authors: R D
authors: RD
authors: Hichwa
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D004007:Dichotic Listening Tests; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008385:Marijuana Smoking / Q000503:physiopathology*; D011597:Psychomotor Performance; D014055:Tomography, Emission-Computed