Absorbable mesh aids in development of discrete, tissue-engineered constructs.
Absorbable mesh was investigated as a potential containment material in which to house discrete, small, tissue-engineered constructs. The mesh was fashioned into bags of varying shapes and consistent volumes. Cells were cultivated on porous, collagen beads, and the tissue constructs were placed into the bags. The mechanical integrity of the bags and feasibility of the design was tested in vitro. The bags successfully maintained their integrity as the cells developed on the collagen matrices. Furthermore, their porosity allowed access of nutrients and waste products to and from the developing tissue. Having demonstrated feasibility of processing, the next step is to optimize the cell culture specifications and materials design.
Burg
K J
KJ
Department of General Surgery Research, Carolinas Medical Center, Charlotte, NC 28232-2861, USA.
Culberson
C R
CR
Greene
K G
KG
Loebsack
A B
AB
Roland
W R
WR
Holder
W D
WD
Halberstadt
C R
CR
Beiler
R J
RJ
D020341:Absorbable Implants; D000818:Animals; D001011:Aorta; D001672:Biocompatible Materials; D002478:Cells, Cultured; D005240:Feasibility Studies; D005260:Female; D008422:Materials Testing; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D011098:Polyglactin 910; D051381:Rats; D017207:Rats, Sprague-Dawley; D013526:Surgical Mesh
D001672:Biocompatible Materials; D011098:Polyglactin 910