title: (-)1-(Benzofuran-2-yl)-2-propylaminopentane shows survival effect on cortical neurons under serum-free condition through sigma receptors.
abstract: 1. The rapid cell death of cortical neurons in serum-free culture was rescued by the condition medium from the high-density culture, but not by brain-derived neurotrophic factor or basic fibroblast growth factor. 2. Similar rescue was observed by the addition of (-)BPAP, an impulse enhancer, and (+)-pentazocine, a sigma receptor agonist. These actions were blocked by BD1063, a sigma receptor antagonist. 3. (-)BPAP showed a weak displacement activity in the [3H]pentazocine binding to synaptic membranes from rat cerebral cortex. 4. These findings suggest that (-)BPAP and (+)-pentazocine have unique survival activity on cortical neurons through sigma receptors.
authors: Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, Japan.
authors: W
authors: W
authors: Hamabe
authors: R
authors: R
authors: Fujita
authors: T
authors: T
authors: Yasusa
authors: F
authors: F
authors: Yoneda
authors: A
authors: A
authors: Yoshida
authors: H
authors: H
authors: Ueda
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology* / Q000502:physiology; D016895:Culture Media, Serum-Free; D005333:Fetus; D007700:Kinetics; D009474:Neurons / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D010423:Pentazocine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000819:agonists / Q000502:physiology*
chemical_list: C404200:1-(benzofuran-2-yl)-2-propylaminopentane; D001572:Benzofurans; D016895:Culture Media, Serum-Free; D017480:Receptors, sigma; D010423:Pentazocine