Mass screening for human papillomavirus type 16 infection in infertile couples.
OBJECTIVE
To investigate the prevalence of human papillomavirus (HPV) type 16 infection among in vitro fertilization (IVF) couples and to identify clinical conditions related to HPV infection.


METHODS
The presence of HPV type 16 DNA in the uterine cervix of 192 women who underwent IVF and in 99 semen samples collected from their husbands were determined by the nested polymerase chain reaction method.


RESULTS
Ten women (5.5%) and 4 men (4.0%) were found to be HPV type 16 DNA positive. However, presence of the HPV type 16 DNA in the cervix or semen did not have any impact on IVF treatment variables, including presence of tubal factor, incidence of pregnancies and abortions, and semen quality. Only one of four women, whose partner's semen was HPV type 16 DNA positive, had a DNA positive cervix.


CONCLUSIONS
These data provide useful information for counseling infertile couples with HPV type 16 infection.
Tanaka
H
H
Department of Obstetrics and Gynecology, Akita University School of Medicine, 1-1-1 Hondo, Akita City, 010-8543, Japan. tanaka-h@synap.ne.jp
Karube
A
A
Kodama
H
H
Fukuda
J
J
Tanaka
T
T
D000328:Adult; D016022:Case-Control Studies; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000628:therapy / Q000821:virology*; D008297:Male; D008403:Mass Screening / Q000379:methods; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012661:Semen / Q000821:virology*; D013076:Sperm Count; D013081:Sperm Motility; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000821:virology*; D002577:Uterine Cervical Diseases / Q000175:diagnosis* / Q000821:virology*
D004279:DNA, Viral