The analgesic potential of intraventricular polymer-encapsulated adrenal chromaffin cells in a rodent model of chronic neuropathic pain.
Adrenal chromaffin cells reportedly produce analgesic effects when implanted in the periaqueductal gray and the intrathecal space near the spinal cord. Chromaffin cells implanted in the cerebral ventricles may also produce analgesic effects, and the availability of the cerebral ventricles as a potential implant site could be advantageous for some patients. In fact, some of the first patients were implanted in the intraventricular site, even though the analgesic potential of that site had never been demonstrated. The present study was conducted to assess the analgesic potential of intraventricular, polymer-encapsulated calf adrenal chromaffin cells in the Bennett model. Sciatic nerve ligations produced substantial, long-lasting pain-related behaviors. However, there was no evidence that polymer-encapsulated adrenal chromaffin cells implanted in the cerebral ventricles produce analgesic effects in this model of chronic neuropathic pain.
Lindner
M D
MD
CytoTherapeutics, Lincoln Rhode Island, USA. mlindner@neurocrine.com
Francis
J M
JM
Plone
M A
MA
McDermott
P E
PE
Frydel
B R
BR
Emerich
D F
DF
Saydoff
J A
JA
D000311:Adrenal Glands / Q000166:cytology; D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002417:Cattle; D017690:Cell Transplantation; D019439:Chromaffin Cells / Q000502:physiology* / Q000637:transplantation; D002908:Chronic Disease; D004195:Disease Models, Animal; D005731:Ganglionic Stimulants / Q000494:pharmacology; D018737:Hand Strength / Q000502:physiology; D006358:Hot Temperature; D006930:Hyperalgesia / Q000517:prevention & control; D007276:Injections, Intraventricular; D008297:Male; D009538:Nicotine / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology; D059408:Pain Management; D011108:Polymers / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D014110:Touch
D000700:Analgesics; D005731:Ganglionic Stimulants; D011108:Polymers; D009538:Nicotine