Physiological rationale for suppression of fever.
Two critical assumptions are made when prescribing antipyretic therapy. One is that fever is, at least in part, noxious, and the other is that suppression of fever will reduce, if not eliminate, the noxious effects of fever. At present, neither assumption has been validated experimentally.
Mackowiak
P A
PA
Medical Care Clinical Center, Veterans Affairs Maryland Health Care System, and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Philip.Mackowiak@med.va.gov
D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000818:Animals; D005075:Biological Evolution; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000378:metabolism; D005334:Fever / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D015203:Reproducibility of Results
D018712:Analgesics, Non-Narcotic; D016207:Cytokines