title: Searching for the polycystic ovary syndrome genes.
abstract: PCOS is a common disorder of unknown etiology. Studies of first-degree relatives of women diagnosed with PCOS suggest familial clustering of the disease. A prospective study of first-degree female relatives of women with PCOS conducted by NCPIR found that 46% of ascertainable sisters of women with PCOS were hyperandrogenemic. NCPIR has conducted linkage and association studies using affected sibling-pair analysis and the transmission/disequilibrium test to explore candidate PCOS genes. These studies point a finger at a region 1 MB centromeric to the insulin receptor gene on chromosome 19.
authors: National Cooperative Program in Infertility Research, Department of Genetics, University of Pennsylvania, Philadelphia, USA.
authors: M
authors: M
authors: Urbanek
authors: R S
authors: RS
authors: Legro
authors: D
authors: D
authors: Driscoll
authors: J F
authors: JF
authors: Strauss
authors: A
authors: A
authors: Dunaif
authors: R S
authors: RS
authors: Spielman
mesh_terms: D005260:Female; D008040:Genetic Linkage; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*