Ventricular fibrillation: how do we stop the waves from breaking?
Combined experimental and theoretical developments have demonstrated that in addition to preexisting electrophysiological heterogeneities, cardiac electrical restitution properties contribute to breakup of reentrant wavefronts during cardiac fibrillation. Developing therapies that favorably alter electrical restitution properties have promise as a new paradigm for preventing fibrillation.
Weiss
J N
JN
Cardiovascular Research Laboratory and the Departments of Medicine (Cardiology), Physiology and Physiological Science, UCLA School of Medicine and Cedars-Sinai Medical Center, Los Angeles, CA 90095-1760, USA. jweiss@mednet.ucla.edu
Chen
P S
PS
Qu
Z
Z
Karagueuzian
H S
HS
Garfinkel
A
A
D000200:Action Potentials / Q000187:drug effects; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D004594:Electrophysiology; D049711:History, Modern 1601-; D006801:Humans; D014693:Ventricular Fibrillation / Q000503:physiopathology* / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents