title: Modulation of the spike activity of neocortex neurons during a conditioned reflex.
abstract: Experiments were conducted on cats to study the effects of iontophoretic application of glutamate and a number of modulators on the spike activity of neurons in the sensorimotor cortex during a conditioned reflex. These studies showed that glutamate, as well as exerting a direct influence on neuron spike activity, also had a delayed facilitatory action lasting 10-20 min after iontophoresis was finished. Adrenomimetics were found to have a double modulatory effect on intracortical glutamate connections: inhibitory and facilitatory effects were mediated by beta1 and beta2 adrenoceptors respectively. Although dopamine, like glutamate, facilitated neuron spike activity during the period of application, the simultaneous facilitatory actions of glutamate and L-DOPA were accompanied by occlusion of spike activity, and simultaneous application of glutamate and haloperidol suppressed spike activity associated with the conditioned reflex response. Facilitation thus appears to show a significant level of dependence on metabotropic glutamate receptors which, like dopamine receptors, are linked to the intracellular medium via Gi proteins.
authors: A A Bogomolets Institute of Physiology, Ukrainian National Academy of Sciences, Kiev.
authors: V M
authors: VM
authors: Storozhuk
authors: A V
authors: AV
authors: Sanzharovskii
authors: V V
authors: VV
authors: Sachenko
authors: B I
authors: BI
authors: Busel
mesh_terms: D000818:Animals; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology; D004576:Electromyography; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D008297:Male; D019579:Neocortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000187:drug effects; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology
chemical_list: D015259:Dopamine Agents; D011941:Receptors, Adrenergic; D018094:Receptors, Metabotropic Glutamate; D013566:Sympathomimetics