title: How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1.
abstract: Halogenated furanones produced by the benthic marine macroalga Delisea pulchra inhibit swarming motility of Serratia liquefaciens MG1. This study demonstrates that exogenously added furanones control transcription of the quorum sensing regulated gene swrA in competition with the cognate signal molecule N:-butanoyl-L-homoserine lactone. This in turn results in reduced production of the surface-active compound serrawettin W2, which is crucial for surface translocation of the differentiated swarm cells. It is demonstrated that furanones interfere with interspecies communication during swarming of mixed cultures and that the mode of interference in quorum-sensing control and interspecies communication is not through inhibition of autoinducer synthesis.
authors: Department of Microbiology, Technical University of Denmark, 2800 Lyngby, Denmark1.
authors: Thomas Bovbjerg
authors: TB
authors: Rasmussen
authors: Centre for Marine Biofouling and Bio-Innovation, University of New South Wales, Sydney, Australia3.|School of Microbiology and Immunology, University of New South Wales, Sydney, Australia2.
authors: Michael
authors: M
authors: Manefield
authors: Department of Microbiology, Technical University of Denmark, 2800 Lyngby, Denmark1.
authors: Jens Bo
authors: JB
authors: Andersen
authors: Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, Freising Munich, D-85350, Germany4.
authors: Leo
authors: L
authors: Eberl
authors: Marine Chemistry Section, H. C. Ørsted Institute, University of Copenhagen, 2100 Copenhagen, Denmark5.
authors: Uffe
authors: U
authors: Anthoni
authors: Marine Chemistry Section, H. C. Ørsted Institute, University of Copenhagen, 2100 Copenhagen, Denmark5.
authors: Carsten
authors: C
authors: Christophersen
authors: Centre for Marine Biofouling and Bio-Innovation, University of New South Wales, Sydney, Australia3.|School of Microbiology and Immunology, University of New South Wales, Sydney, Australia2.
authors: Peter
authors: P
authors: Steinberg
authors: Centre for Marine Biofouling and Bio-Innovation, University of New South Wales, Sydney, Australia3.|School of Microbiology and Immunology, University of New South Wales, Sydney, Australia2.
authors: Staffan
authors: S
authors: Kjelleberg
authors: Department of Microbiology, Technical University of Denmark, 2800 Lyngby, Denmark1.
authors: Michael
authors: M
authors: Givskov
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism; D005663:Furans / Q000378:metabolism / Q000494:pharmacology*; D015964:Gene Expression Regulation, Bacterial; D008074:Lipoproteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D008163:Luminescent Measurements; D009068:Movement / Q000187:drug effects / Q000502:physiology; D010456:Peptides, Cyclic / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D000461:Rhodophyta / Q000378:metabolism*; D012705:Serratia / Q000187:drug effects* / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects*; D014158:Transcription, Genetic
chemical_list: D005663:Furans; D008074:Lipoproteins; D010456:Peptides, Cyclic; C088386:homoserine lactone; C073497:serrawettin W2; D015107:4-Butyrolactone