Simultaneous MRI measurement of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents.
A technique for the simultaneous measurement of three vascular parameters: blood flow (Frho), blood volume (v(b)), and the capillary permeability-surface area product (PSrho) in breast tumors using dynamic contrast-enhanced magnetic resonance imaging (MRI) is presented. Features of the technique include measurement of precontrast tumor T(1), rapid temporal sampling, measurement of the arterial input function, and use of a distributed parameter tracer kinetic model. Parameter measurements are compared that were determined using two contrast agents of different molecular weights, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA; 0.6 kDa) and Gadomer-17 (17 kDa), in 18 spontaneous canine mammary tumors. Measurements of Frho and v(b) corresponded well with literature values, and the mean PSrho measured using Gd-DTPA was a factor of 15 higher than that measured using Gadomer-17. J. Magn. Reson. Imaging 2000;12:991-1003.
Henderson
E
E
Imaging Division, Lawson Health Research Institute, St. Joseph's Health Care, London, Ontario, Canada, N6A 4V2.
Sykes
J
J
Drost
D
D
Weinmann
H J
HJ
Rutt
B K
BK
Lee
T Y
TY
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D002199:Capillary Permeability / Q000502:physiology*; D003287:Contrast Media; D004283:Dog Diseases / Q000175:diagnosis / Q000503:physiopathology; D004285:Dogs; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008321:Mammary Glands, Animal / Q000098:blood supply; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply*; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity
D003287:Contrast Media; C402765:gadomer 17; D005682:Gadolinium; D019786:Gadolinium DTPA