title: Biochemical responses in a Candida famata strain adapted to high copper concentrations.
abstract: A strain of Candida famata adapted to high copper concentration (1.26 mM) and a number of biochemical parameters have been tested, in order to get information on the mechanisms of metal toxicity and detoxification as well as on the metabolic responses to the treatment. The cytoplasmic levels of superoxide dismutase, peroxidase and glutathione were found significantly increased with respect to control cells, in contrast to catalase which is not affected. The activities of enolase and of triosephosphate isomerase are found to decrease as a consequence of the exposure to copper. Statistically significant differences in the content of some aminoacids are found between copper-treated and control cells.
authors: Dipartimento di Scienze degli Alimenti, Universitá di Udine, Italia.
authors: M
authors: M
authors: Manzano
authors: L
authors: L
authors: Cocolin
authors: B
authors: B
authors: Citterio
authors: L
authors: L
authors: Conte
authors: M
authors: M
authors: de Bertoldi
authors: G
authors: G
authors: Comi
authors: G
authors: G
authors: Santovito
authors: M
authors: M
authors: Beltramini
authors: B
authors: B
authors: Salvato
mesh_terms: D000222:Adaptation, Physiological; D000596:Amino Acids / Q000378:metabolism; D002175:Candida / Q000737:chemistry / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D003300:Copper / Q000378:metabolism* / Q000633:toxicity; D004789:Enzyme Activation / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000596:Amino Acids; D003300:Copper; D013482:Superoxide Dismutase; D005978:Glutathione