Susceptibility mutations for ischemic heart disease.
In The Copenhagen City Heart Study, apolipoprotein B Arg3500Gln and Arg3531Cys increased plasma cholesterol 41% and 0%, lipoprotein lipase Gly188Glu, Asn291Ser, and Asp9Asn increased plasma triglycerides 42%, 13% (women only), and 13% (men only), and angiotensin converting enzyme DD increased plasma ACE activity 57%. Risk of ischemic heart disease for these mutations was sevenfold, unchanged, fivefold, twofold (women only), twofold (men only), and unchanged, respectively, compared with threefold for diabetes mellitus. The fraction of ischemic heart disease in the population at large attributed to these mutations was 0.5%, 0%, 0.3%, 5% (women only), 3% (men only), and 0%, respectively, compared with 7% for diabetes mellitus.
Nordestgaard
B G
BG
Herlev University Hospitals and The Copenhagen City Heart Study, Copenhagen, Denmark.
Tybjaerg-Hansen
A
A
D001055:Apolipoproteins B / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D009154:Mutation; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D014280:Triglycerides / Q000097:blood
D001055:Apolipoproteins B; D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase; D007703:Peptidyl-Dipeptidase A