title: Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome.
abstract: Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 microM), a metabolite of the dopamine oxidative pathway, was found to down regulate the expression of angiotensin receptor mRNA in RCSN3 cells by 83% (p < 0.05).
authors: Program of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago.
authors: A
authors: A
authors: Dagnino-Subiabre
authors: K
authors: K
authors: Marcelain
authors: C
authors: C
authors: Arriagada
authors: I
authors: I
authors: Paris
authors: P
authors: P
authors: Caviedes
authors: R
authors: R
authors: Caviedes
authors: J
authors: J
authors: Segura-Aguilar
mesh_terms: D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D008058:Dihydrolipoamide Dehydrogenase / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D045563:Indolequinones; D007211:Indoles / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011945:Receptors, Angiotensin / Q000235:genetics* / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects
chemical_list: D045563:Indolequinones; D007211:Indoles; D012333:RNA, Messenger; D011945:Receptors, Angiotensin; D000804:Angiotensin II; C091584:aminochrome 1; D008058:Dihydrolipoamide Dehydrogenase