Hyperglycemia, hyperlipemia, and periodic paralysis: a case report of new side effects of clozapine.
1. This case report of a Chinese male schizophrenic patient describes new side effects that have not been documented previously for patients treated with clozapine. At certain doses of clozapine, the patient showed direct adverse reactions, which include a combination of hyperglycemia, hyperlipemia, and periodic paralysis. 2. In a four-year study of this patient who had no previous episodes of diabetes in his or his family history, the authors found that these symptoms disappeared upon withdrawal of clozapine and relapsed with re-treatment of the drug. This study indicates that hyperglycemia, hyperlipemia, and periodic paralysis may need to be monitored on patients treated with clozapine.
Wu
G
G
Yueyang Center of Mental Health, Yueyang, PR China.
Dias
P
P
Chun
W
W
Li
G
G
Kumar
S
S
Singh
S
S
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D006949:Hyperlipidemias / Q000139:chemically induced*; D008297:Male; D010243:Paralysis / Q000139:chemically induced*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D014280:Triglycerides / Q000097:blood
D014150:Antipsychotic Agents; D001786:Blood Glucose; D014280:Triglycerides; D003024:Clozapine