Effect of thyroidectomy on fast and slow muscle fibres of rat gastrocnemius muscle.
A combined histochemical, biochemical and electrophoretic study with respect to the enzymes succnic dehydrogenase(SDH), myofibrillar adenosine triphosphatase (m-ATPase), lactate dehydrogenase (LDH) isozymes and myosin light chains was carried out to investigate the response of rat gastrocnemius muscle (medial head). Twelve weeks after thyroidectomy, the results indicated a shift from fast to slow type pattern of LDH isozymes, fibre type transformation from Type II to Type I and a decrease in SDH and m-ATPase activity. The results suggest, possible thyroidal involvement in determining the phenotypic properties of skeletal muscle.
Vashishta
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Muscle Physiology & Histochemistry Unit, Department of Zoology, University of Delhi, Delhi 110007, India.
Talesara
C L
CL
D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D007037:Hypothyroidism / Q000201:enzymology / Q000209:etiology / Q000473:pathology*; D007527:Isoenzymes / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000201:enzymology / Q000473:pathology*; D018657:Muscle Fibers, Slow-Twitch / Q000201:enzymology / Q000473:pathology*; D009124:Muscle Proteins / Q000032:analysis; D018994:Myosin Light Chains / Q000032:analysis; D051381:Rats; D013385:Succinate Dehydrogenase / Q000032:analysis; D013965:Thyroidectomy / Q000009:adverse effects*
D007527:Isoenzymes; D009124:Muscle Proteins; D018994:Myosin Light Chains; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000251:Adenosine Triphosphatases