Sjögren's syndrome induced by estrogen therapy.
OBJECTIVE
To describe a possible role for estrogen in the induction or acceleration of Sjögren's syndrome (SS).


METHODS
Two healthy young women who received estrogen-increasing therapy and then developed full-blown SS are described. The relationship between SS and estrogen therapy is discussed and the available literature reviewed.


RESULTS
Both women developed SS 3 years after starting estrogen-increasing treatment. The syndrome was severe in the first patient, who was treated with a high dosage of estrogen; the disease was moderate in the second patient, who received a lower estrogen dosage.


CONCLUSIONS
Estrogen may play a role in the pathogenesis of SS in some patients.
Nagler
R M
RM
Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel. nagler@tx.technion.ac.il
Pollack
S
S
D000328:Adult; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012859:Sjogren's Syndrome / Q000139:chemically induced* / Q000473:pathology
D004967:Estrogens