title: Cholesterol granulomas in three meerkats (Suricata suricatta).
abstract: Cholesterol granulomas are uncommon pathologic lesions in animals, although they are important intracranial tumors in humans. This report describes cholesterol granulomas associated with multiple organ systems of three captive meerkats. In the most severe case, meerkat No. 1, the pathologic behavior of the cholesterol granuloma was unique in that it appeared to locally invade the cerebrum and calvarium, possibly contributing to neurological deficits observed antemortem. A review of other meerkat necropsies revealed incidental, asymptomatic cholesterol granulomas in organs of two other individuals, meerkat Nos. 2 and 3. Histologically, all lesions were composed of cholesterol clefts admixed with large, foamy macrophages containing hemosiderin, multinucleated giant cells, lymphocytes, plasma cells, and foci of mineralization. Hypercholesterolemia was documented in two of the three meerkats.
authors: Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA. kksladky@aol.com
authors: K K
authors: KK
authors: Sladky
authors: F G
authors: FG
authors: Dalldorf
authors: H
authors: H
authors: Steinberg
authors: J F
authors: JF
authors: Wright
authors: M R
authors: MR
authors: Loomis
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002335:Carnivora; D002784:Cholesterol; D017809:Fatal Outcome; D006099:Granuloma / Q000473:pathology / Q000662:veterinary*; D008297:Male
chemical_list: D002784:Cholesterol