Polymer-supported tetrafluorophenol: a new activated resin for chemical library synthesis.
A new tetrafluorophenol activated resin that facilitates the use of 19F NMR to quantitate loading is presented. This new resin provides a useful tool for acylation, and a novel activated polymeric sulfonate ester to generate sulfonamides. This activated resin reacts with a wide scope of N-nucleophiles including primary and secondary amines, and anilines. This new activated resin methodology provides a powerful tool for pure single-compound library synthesis.
Salvino
J M
JM
Lead Discovery Department, Rhone Poulen Rorer, Collegeville, Pennsylvania 19426, USA.
Kumar
N V
NV
Orton
E
E
Airey
J
J
Kiesow
T
T
Crawford
K
K
Mathew
R
R
Krolikowski
P
P
Drew
M
M
Engers
D
D
Krolikowski
D
D
Herpin
T
T
Gardyan
M
M
McGeehan
G
G
Labaudiniere
R
R