Ceftriaxone induced lipid peroxidation and its inhibition with various antioxidants: Part II. Evaluation of glutathione and probucol as antioxidants.
Exploratory studies on drug induced lipid peroxidation in goat whole blood and its inhibition with antioxidants were carried out using sodium ceftriaxone (CTS) as the representative drug and glutathione and probucol as the representative antioxidants. The studies showed that CTS could induce lipid peroxidation to a significant extent. Lipid peroxidation is a toxicity mediating process, this finding may be correlated with the toxic potential of the drug. It was further found that glutathione and probucol caused significant suppression of CTS induced lipid peroxidation. The results suggest that glutathione and probucol merit further assessment to explore their potential to reduce drug induced lipid peroxidation and thus to increase therapeutic index of the drug by way of reducing toxicity that may be mediated through free radical mechanism.
Roy
K
K
Division of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757086, Orissa, India.
Saha
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A
De
K
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Sengupta
C
C
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000931:Antidotes / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D002443:Ceftriaxone / Q000037:antagonists & inhibitors / Q000633:toxicity*; D002511:Cephalosporins / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005978:Glutathione / Q000494:pharmacology*; D006041:Goats; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood; D011341:Probucol / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D000931:Antidotes; D000975:Antioxidants; D002511:Cephalosporins; D008054:Lipid Peroxides; D002443:Ceftriaxone; D005978:Glutathione; D011341:Probucol