Induction of polyomavirus-specific CD8(+) T lymphocytes by distinct dendritic cell subpopulations.
Dendritic cells are pivotal antigen-presenting cells for generating adaptive T-cell responses. Here, we show that dendritic cells belonging to either the myeloid-related or lymphoid-related subset are permissive for infection by mouse polyomavirus and, when loaded with a peptide corresponding to the immunodominant anti-polyomavirus CD8(+) T-cell epitope or infected by polyomavirus, are each capable of driving expansion of primary polyomavirus-specific CD8(+) T-cell responses in vivo.
Drake
D R
DR
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Shawver
M L
ML
Hadley
A
A
Butz
E
E
Maliszewski
C
C
Lukacher
A E
AE
D000818:Animals; D018845:CD11 Antigens / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D016466:CHO Cells; D006224:Cricetinae; D003713:Dendritic Cells / Q000502:physiology*; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D011120:Polyomavirus / Q000276:immunology*
D018845:CD11 Antigens