title: Chemical synthesis of sulfated oligosaccharides with a beta-D-Gal-(1-->3).
abstract: The syntheses of two sulfated pentasaccharides: beta-D-Gal6SO3Na-(1-->3)-[beta-D-Gal-(1-->4)-alpha-L-Fuc-(1-->3)-beta-D-Glc-NAc-(1-->6)]-alpha-D-GalNAc-->OMe (1) and beta-D-Gal6SO3Na-(1-->3)-[beta-D-Gal-(1-->4)-alpha-L-Fuc-(1-->3)-beta-D-Glc-NAc6SO3Na-(1-->6)]-alpha-D-GalNAc-->OMe (2) by using Lewisx trisaccharides 12 and 16 as glycosyl donors are described. Sulfated oligosaccharides 1-2 and intermediate compounds are fully characterized by 2D 1H-1H DQF-COSY and 2D ROESY experiments.
authors: Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors: J
authors: J
authors: Xia
authors: T
authors: T
authors: Srikrishnan
authors: J L
authors: JL
authors: Alderfer
authors: R K
authors: RK
authors: Jain
authors: C F
authors: CF
authors: Piskorz
authors: K L
authors: KL
authors: Matta
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D019087:Selectins / Q000378:metabolism
chemical_list: D008024:Ligands; D009844:Oligosaccharides; D019087:Selectins