Immunobiology of xenotransplantation.
The transplantation of organs between disparate species is hindered by severe immune responses of the recipient against the graft. These immune responses gives rise to hyperacute and acute vascular rejection and to cellular rejection. Research during the past decade has shed light on the elements of the immune system responsible for the rejection of xenografts and has provided novel and incisive therapies which might be applied to these problems.
Platt
J L
JL
Mayo Clinic, Rochester, MN 55905, USA. platt.jeffrey@mayo.edu
D000208:Acute Disease; D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology; D000917:Antibody Formation; D003165:Complement System Proteins / Q000502:physiology; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D007111:Immunity, Cellular; D014183:Transplantation, Heterologous / Q000276:immunology*
D000910:Antibodies, Heterophile; D003165:Complement System Proteins