Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy.
OBJECTIVE
To investigate the representation of the corneal structure with optical coherence tomography before and immediately after excimer laser photorefractive keratectomy.


METHODS
Twenty-four eyes of 24 patients with myopia and myopic astigmatism were prospectively studied. The corneal thickness and the corneal profile were assessed with slit-lamp-adapted optical coherence tomography preoperatively and immediately after excimer laser photorefractive keratectomy.


RESULTS
The attempted mean spherical equivalent of the refractive corrections was -6.7 +/- 3.6 (mean +/- SD) diopters with a mean calculated stromal ablation depth of 91 +/- 38 microm. The corneal optical coherence tomography was reproducible in all patients, demonstrating a mean decrease of central corneal thickness after epithelial debridement and excimer laser photorefractive keratectomy of 118 +/- 45 microm. The comparison of the calculated stromal ablation depth and the corneal thickness changes determined by corneal optical coherence tomography revealed a significant linear relationship with a correlation coefficient of 0.88 (P <.001). The flattening of the corneal curvature was confirmed in all patients with the optical coherence tomography system and correlated with the attempted refractive correction (r =.82, P <.001).


CONCLUSIONS
The slit-lamp-adapted optical coherence tomography system presented in this study allowed noncontact, cross-sectional, and high-resolution imaging of the corneal configuration. This initial clinical evaluation demonstrated that corneal optical coherence tomography could be a promising diagnostic modality to monitor corneal changes of thickness and curvature before and after excimer laser photorefractive keratectomy.
Wirbelauer
C
C
Augenklinik der Medizinischen Universität zu Lübeck (Drs Wirbelauer, Hoerauf, and Laqua), Lübeck, Germany. augen@knk-berlin.de
Scholz
C
C
Hoerauf
H
H
Engelhardt
R
R
Birngruber
R
R
Laqua
H
H
D000328:Adult; D001251:Astigmatism / Q000175:diagnosis* / Q000601:surgery; D003315:Cornea / Q000473:pathology* / Q000601:surgery; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007368:Interferometry; D054018:Lasers, Excimer; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000175:diagnosis* / Q000601:surgery; D018903:Photorefractive Keratectomy; D011446:Prospective Studies; D012029:Refraction, Ocular; D015203:Reproducibility of Results; D013016:Sound; D014054:Tomography