[Genetic analysis of tick-borne encephalitis virus strains from West Siberia].
Tick-borne encephalitis (TBE) virus strains were isolated in West Siberia in the forest-steppe region near the Ob river in 1981-1992. Hybridization of genome RNA of 46 TBE strains with [32P]cDNA of TBE Sofyin strain revealed essential differences in the genomes of West-Siberian and Far-Eastern Sofyin strains of TBE virus. Nucleotide sequences of 6 TBE strains (1348-1503 n.) have been determined. A 89-98% homology of Siberian TBE strains has been shown, while the similarity of the respective fragment of E gene for West Siberian and Sofyin strains was no more than 81%. No significant changes in E gene of TBE strains have been detected over a 12-year period.
Bakhvalova
V N
VN
Rar
V A
VA
Tkachev
S E
SE
Dobrikova
E Iu
EIu
Morozova
O V
OV
D001483:Base Sequence; D004669:Encephalitis Viruses, Tick-Borne / Q000235:genetics*; D004675:Encephalitis, Tick-Borne / Q000821:virology*; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D012800:Siberia