Is there epidemiologic evidence that anti-oxidants protect against disorders in cognitive function?
Experimental studies have identified several pathways through which oxidative stress could adversely affect cognitive function and increase the risk for dementia. Anti-oxidant supplements have been proposed as interventions for secondary or primary prevention against dementia. The existing observational studies and randomized trials examining anti-oxidants and cognitive function outcomes are reviewed. A discussion is provided of methodologic limitations of existing studies and possible directions for future investigations.
Launer
L J
LJ
Epidemiology, Demography, Biometry Program, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Ave, 3C-309, Bethesda, MD 20892 USA. launerl@exmur.nia.nih.gov
D000375:Aging; D000975:Antioxidants / Q000627:therapeutic use*; D003704:Dementia / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D019587:Dietary Supplements; D016021:Epidemiologic Studies; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D011322:Primary Prevention; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
D000975:Antioxidants