title: Predominance of canine parvovirus (CPV) in unvaccinated cat populations and emergence of new antigenic types of CPVs in cats.
abstract: Serological, sequence, and in vitro host range analyses of feline parvovirus (FPV) isolates in Vietnam and Taiwan revealed that more than 80% of the isolates were of the canine parvovirus (CPV) type, rather than feline panleukopenia virus (FPLV). Although parvovirus isolates from three Vietnamese leopard cats were genetically related to CPV type 2a or 2b, they had a natural mutation of VP2 residue 300 Gly to an Asp, resulting in remarkable changes in their antigenic properties. These results indicated the possibility that CPV-2a/2b-type viruses can spread in cats more efficiently than conventional FPLV under natural conditions and that CPV-2a/2b viruses are further evolving in cats.
authors: Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, Bunkyo-ku, Tokyo, 113-8657, Japan.
authors: Y
authors: Y
authors: Ikeda
authors: M
authors: M
authors: Mochizuki
authors: R
authors: R
authors: Naito
authors: K
authors: K
authors: Nakamura
authors: T
authors: T
authors: Miyazawa
authors: T
authors: T
authors: Mikami
authors: E
authors: E
authors: Takahashi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000940:Antigenic Variation; D000956:Antigens, Viral / Q000032:analysis; D001216:Asparagine / Q000235:genetics; D002213:Capsid / Q000235:genetics; D002335:Carnivora / Q000821:virology*; D002415:Cats / Q000821:virology*; D028301:Feline Panleukopenia Virus / Q000145:classification* / Q000235:genetics / Q000276:immunology; D005998:Glycine / Q000235:genetics; D006385:Hemagglutination Inhibition Tests / Q000662:veterinary; D008969:Molecular Sequence Data; D009154:Mutation; D017993:Parvovirus, Canine / Q000145:classification* / Q000235:genetics; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013624:Taiwan; D014744:Vietnam
chemical_list: D000956:Antigens, Viral; D001216:Asparagine; D005998:Glycine