IGF-1 and its binding proteins IGFBP-1 and 3 as nutritional markers in prepubertal children.
OBJECTIVE
To assess the validity of the use of IGF-1, IGFBP-1 and IGFBP-3 as biochemical markers of nutritional status in prepubertal healthy children.


METHODS
Cross-sectional survey.


METHODS
Healthy children from the Madrid area.


METHODS
Prepubertal children (aged 7-10 years) with a body mass index (BMI) above the 90th percentile (n = 25) and below the 10th percentile (n = 31) were selected from 2,559 included in the CAENPE study (Food Intake and Nutritional Status in Schoolchildren from Madrid).


RESULTS
Overweight children were found to have higher serum levels of IGF-1 (306+/-162.2 vs. 209+/-71.2 ng/ml, p<0.001) and IGFBP-3 (3.3+/-1.0 vs. 2.9+/- 0.5 mg/l, p<0.01) and lower serum levels of IGFBP-1 (4.3+/-3.9 vs. 13.8+/-7.4 microg/l, p<0.01). There was a positive correlation with BMI, for IGF-1 and IGFBP-3, and negative correlation for IGFBP-1. No differences in albumin and transferrin concentrations were observed between both groups of children.


CONCLUSIONS
IGF-1, IGFBP-1 and IGFBP-3 clearly classify over- and underweight prepubertal children, showing a good correlation with BMI. They can be used as biochemical markers of caloric nutritional status in this population.
Martínez de Icaya
P
P
Division of Endocrinology and Nutrition, Hospital Severo Ochoa, Leganés, Madrid, Spain.
Fernández
C
C
Vázquez
C
C
del Olmo
D
D
Alcázar
V
V
Hernández
M
M
D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D009752:Nutritional Status; D011863:Radioimmunoassay; D015203:Reproducibility of Results; D012709:Serum Albumin / Q000032:analysis; D013030:Spain; D011795:Surveys and Questionnaires; D014168:Transferrin / Q000032:analysis
D015415:Biomarkers; D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D012709:Serum Albumin; D014168:Transferrin; D007334:Insulin-Like Growth Factor I