The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats.
The influence of some anticholinergic drugs (atropine, benactyzine, biperiden, scopolamine) on the efficacy of antidotal treatment to eliminate soman (O-pinacolyl methylphosphonofluoridate)-induced disturbance of respiration and circulation and to protect experimental animals poisoned with supralethal dose of soman (1.5 x LD(50)) was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. While the oxime HI-6 in combination with atropine prevented soman-induced changes in monitored physiological parameters insufficiently and very shortly, the combination of HI-6 with benactyzine or biperiden is able to prevent soman-induced alteration of respiration and circulation much more longer. Nevertheless, only rats treated with HI-6 in combination with scopolamine were fully protected against the lethal toxic effects of soman within 2 h following soman challenge. Our findings confirm that anticholinergic drugs with the strong central antimuscarinic activity, such as benactyzine, biperiden and especially scopolamine, seem to be more effective adjuncts to HI-6 treatment of severe acute soman-induced poisoning than atropine.
Kassa
J
J
Purkynĕ Military Medical Academy, PO Box 35/T, 500 01, Hradec Králové, Czech Republic. kassa@pmfhk.cz
Fusek
J
J
D000818:Animals; D000931:Antidotes / Q000494:pharmacology* / Q000592:standards; D001285:Atropine / Q000494:pharmacology / Q000592:standards; D001535:Benactyzine / Q000494:pharmacology / Q000592:standards; D001712:Biperiden / Q000494:pharmacology / Q000592:standards; D001794:Blood Pressure; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000494:pharmacology* / Q000592:standards; D004562:Electrocardiography; D006339:Heart Rate; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology / Q000592:standards; D010091:Oximes; D011726:Pyridinium Compounds / Q000494:pharmacology / Q000592:standards; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology / Q000592:standards; D012999:Soman / Q000633:toxicity*
D000931:Antidotes; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D018727:Muscarinic Antagonists; D010091:Oximes; D011726:Pyridinium Compounds; D001712:Biperiden; D001535:Benactyzine; D001285:Atropine; D012999:Soman; D012601:Scopolamine; C022870:asoxime chloride