[Consequences of intravascular contrast media on kidney function-- risk and prevention].
The use of iodinated contrast media (CM) continues to be a common cause of hospital-acquired acute renal failure (ARF) and its development increases the in-hospital mortality significantly. Alterations in renal hemodynamics and direct tubular toxicity by contrast media are the primary factors believed to be responsible for contrast media-associated nephrotoxicity. We review recent insights into the pathogenesis of this complication and summarize prophylactic strategies focussing on hydration, vasoactive pharmacological agents, alternative contrast media and "prophylactic hemodialysis".
Erley
C M
CM
Abteilung Innere Medizin III, Universität Tübingen. christiane.erley@med.uni-tuebingen.de
Bader
B D
BD
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000453:epidemiology / Q000517:prevention & control; D003287:Contrast Media / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D012079:Renal Circulation / Q000187:drug effects; D012307:Risk Factors
D003287:Contrast Media; D007457:Iodine Radioisotopes