Immunogenetic associations in childhood dermatomyositis.
Childhood dermatomyositis is a multisystem autoimmune disease characterized by acute and chronic inflammatory infiltrate and vasculitis seen primarily in skin and muscle. The disease occurs in genetically susceptible individuals with a yet undescribed environmental trigger. Genetic associations in this disease demonstrate disease susceptibility as well as chronicity and severity and likely play a role in disease pathogenesis. The majority of the associations to date have been seen with the HLA alleles, with additional immune responsive and influential genes being increasingly investigated.
Reed
A M
AM
Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. reed.ann18@mayo.edu
D002648:Child; D003882:Dermatomyositis / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D006360:Heat-Shock Proteins / Q000235:genetics; D006649:Histocompatibility Antigens / Q000235:genetics; D006801:Humans; D007375:Interleukin-1; D018598:Minisatellite Repeats; D011110:Polymorphism, Genetic; D012307:Risk Factors
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D006360:Heat-Shock Proteins; D006649:Histocompatibility Antigens; D007375:Interleukin-1