Direct ex vivo measurement of CD8(+) T-lymphocyte responses to human parvovirus B19.
Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8(+) T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.
Tolfvenstam
T
T
Department of Virology, Karolinska Institute, Stockholm, Sweden.
Oxenius
A
A
Price
D A
DA
Shacklett
B L
BL
Spiegel
H M
HM
Hedman
K
K
Norbeck
O
O
Levi
M
M
Olsen
K
K
Kantzanou
M
M
Nixon
D F
DF
Broliden
K
K
Klenerman
P
P
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015797:HLA-B35 Antigen / Q000502:physiology; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D016732:Parvovirus B19, Human / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000276:immunology
D015797:HLA-B35 Antigen; D017361:Viral Nonstructural Proteins; D017493:Leukocyte Common Antigens