Improved synthesis of the iodine-free thyromimetic GC-1.
Synthesis of the TRbeta-selective thyromimetic GC-1 has been improved using methoxymethyl (MOM) and triisopropylsilyl (TiPS) substituents as phenolic protecting groups. The new synthetic route is adaptable to analogue design.
Chiellini
G
G
Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446, USA.
Nguyen
N H
NH
Yoshihara
H A
HA
Scanlan
T S
TS
D007455:Iodine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018716:Molecular Mimicry; D013963:Thyroid Hormones / Q000138:chemical synthesis* / Q000737:chemistry
D013963:Thyroid Hormones; D007455:Iodine