title: Recurrent penicillin-resistant pneumococcal sepsis after matched unrelated donor (MUD) transplantation for refractory T cell lymphoma.
abstract: Patients who undergo splenectomy and recipients of allogeneic marrow (alloBMT) or peripheral stem cell transplantation are at increased risk of overwhelming infection from encapsulated organisms such as Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis. As prophylaxis against these pathogens splenectomised patients are immunised and may also receive antibiotics for life. We report relapsing overwhelming sepsis caused by penicillin-resistant pneumococcus in a patient who was immunised and received prophylactic phenoxymethylpenicillin for 8 months following splenectomy and matched unrelated donor (MUD) marrow transplantation for refractory T cell lymphoma. No obvious focus of sepsis was found during any of the three episodes and S. pneumoniae serogroup 6, subtype 6B was isolated from blood cultures on each occasion. He was treated with i.v. cephalosporins, as the organisms were resistant to penicillin with a minimum inhibitory concentration (MIC) of 2.0, and there was complete resolution of symptoms each time. In the light of recurrent sepsis with this penicillin-resistant organism the decision was made to give prophylactic levofloxacin for the next 12 months. This case illustrates that the choice of prophylactic regimen and the treatment of sepsis in immunocompromised patients remain difficult and challenging issues.
authors: Bone Marrow Transplant Unit, University Hospital Birmingham NHS Trust, UK.
authors: S
authors: S
authors: Tauro
authors: D
authors: D
authors: Dobie
authors: G
authors: G
authors: Richardson
authors: M
authors: M
authors: Hastings
authors: P
authors: P
authors: Mahendra
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D016026:Bone Marrow Transplantation; D002330:Carmustine / Q000008:administration & dosage; D002439:Cefotaxime / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D003586:Cytomegalovirus Infections / Q000209:etiology; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D064704:Levofloxacin; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D015242:Ofloxacin / Q000627:therapeutic use; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D012293:Rifampin / Q000627:therapeutic use; D013156:Splenectomy; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D019172:Transplantation Conditioning / Q000009:adverse effects; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D007166:Immunosuppressive Agents; D003561:Cytarabine; D014750:Vincristine; D064704:Levofloxacin; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D015242:Ofloxacin; D002439:Cefotaxime; D008558:Melphalan; D002330:Carmustine; D011241:Prednisone; D012293:Rifampin; D015255:Idarubicin