Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?
A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated.
Kutter
D
D
Laboratoires réunis Kutter-Lieners-Hastert, Junglinster, Luxembourg.
Devaquet
P
P
Vanderstocken
G
G
Paulus
J M
JM
Marchal
V
V
Gothot
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000201:enzymology / Q000209:etiology; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000517:prevention & control; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007239:Infections / Q000201:enzymology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000517:prevention & control; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology; D009195:Peroxidase / Q000097:blood / Q000172:deficiency* / Q000494:pharmacology; D012307:Risk Factors
D009195:Peroxidase