Differences in phenotype, growth factor requirements, pattern of expression of adhesion molecules and rate of apoptosis displayed by three new myeloid sister leukemic cell lines.
We established three new human myeloid cell lines from one  patient, in the presence of granulocyte-macrophage  colony-stimulating factor (UPM1-GM), interleukin-3  (UMP1-IL-3) or without exogenous growth factors (UPM1).  The 3 lines were characterized by phenotypic, genotypic and  functional studies. These cell lines may provide useful tools  to study different aspects of leukemic cell biology
Quinta-Costa
M
M
Leite
M
M
Simas-Leite
P
P
Correia
C
C
Candeias
J
J
Guimarães
J E
JE
D017209:Apoptosis; D015815:Cell Adhesion Molecules / Q000378:metabolism; D018929:Cell Culture Techniques / Q000379:methods; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D016130:Immunophenotyping; D007951:Leukemia, Myeloid / Q000276:immunology / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000473:pathology
D015815:Cell Adhesion Molecules; D006133:Growth Substances