title: Molecular evidence for multicentric development of thyroid carcinomas in patients with familial adenomatous polyposis.
abstract: Familial adenomatous polyposis is characterized by multiple colorectal adenomas and an increased incidence of colorectal carcinomas. Patients also develop various extracolonic tumors, of which, thyroid carcinoma is common in young females. The occurrence of multiple carcinomas in one thyroid is frequently observed, although some carcinomas are solitary. To clarify whether each carcinoma develops independently or metastatically spreads from the first one formed, we analyzed the adenomatous polyposis coli (APC) gene mutation in each carcinoma. We found that each carcinoma had a different somatic mutation of the APC gene. This is molecular confirmation for the multicentric development of thyroid carcinomas in familial adenomatous polyposis through biallelic inactivation of the APC gene.
authors: Hereditary Tumor Research Project, Department of Pathology, Tokyo Metropolitan Komagome Hospital. Institute of Molecular Oncology. Showa University. Sasaki Institute, Tokyo, Japan. mmiyaki@opal.famille.ne.jp
authors: M
authors: M
authors: Miyaki
authors: T
authors: T
authors: Iijima
authors: R
authors: R
authors: Ishii
authors: T
authors: T
authors: Hishima
authors: T
authors: T
authors: Mori
authors: K
authors: K
authors: Yoshinaga
authors: H
authors: H
authors: Takami
authors: T
authors: T
authors: Kuroki
authors: T
authors: T
authors: Iwama
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics*; D000328:Adult; D000483:Alleles; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005260:Female; D020868:Gene Silencing; D017491:Genes, APC / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology*