title: Healon5 versus Viscoat during cataract surgery: intraocular pressure, laser flare and corneal changes.
abstract: BACKGROUND
  The use of a viscoelastic substance facilitates cataract surgery. Healon 5 is a new viscoelastic product with special rheological properties. We evaluated the postoperative effect of Viscoat and Healon5 on intraocular pressure (IOP), central corneal thickness (CCT), endothelial cell counts and laser flare.
  
  
  METHODS
  Forty-eight eyes of 48 patients undergoing routine phacoemulsification followed by foldable IOL implantation were enrolled. Either Healon5 or Viscoat was used according to a block-randomization scheme. The aspiration technique was standardized. IOP, CCT, endothelial cell counts and laser flare were compared pre- and postoperatively. Statistical analysis was performed using the two-sample Wilcoxon test. Data description was based on median and quartiles, while graphic description was performed by non-parametric box plots.
  
  
  RESULTS
  Viscoat demonstrated a statistically significant higher IOP than Healon5 at 4 and 8 h postoperatively (P< 0.01 and < 0.05, respectively). Further, the laser flare values were statistically significantly higher for the Viscoat than for the Healon5 group 8 h postoperatively (P<0.05). Endothelial cell loss did not differ significantly between the two groups (relative change in endothelial cell density after 3 months: -4.3% for the Healon5 group and -6.2% for Viscoat group).
  
  
  CONCLUSIONS
  There was neither a statistically nor a clinically significant difference in endothelial cell loss after the use of Healon5 or Viscoat in routine cataract surgery. However, the IOP in the early postoperative period was higher in the Viscoat group than in the Healon5 group.
authors: Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany. Schwenn@augen.klinik.uni-mainz.de
authors: O
authors: O
authors: Schwenn
authors: H B
authors: HB
authors: Dick
authors: F
authors: F
authors: Krummenauer
authors: S
authors: S
authors: Christmann
authors: A
authors: A
authors: Vogel
authors: N
authors: N
authors: Pfeiffer
mesh_terms: D000328:Adult; D001082:Aqueous Humor / Q000378:metabolism*; D002452:Cell Count; D002807:Chondroitin / Q000009:adverse effects / Q000627:therapeutic use*; D002809:Chondroitin Sulfates; D004338:Drug Combinations; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular; D008297:Male; D018918:Phacoemulsification; D010783:Photometry; D011446:Prospective Studies
chemical_list: D004338:Drug Combinations; C501944:chondroitin sulfate, sodium hyaluronate drug combination; D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates