Retinoic acid enhances the rate of olfactory recovery after olfactory nerve transection.
In the olfactory system, retinoic acid (RA) plays an important role in development and may affect growth in the adult animal. To explore the potential effects of RA on recovery after injuries, adult mice were trained in a buried food paradigm and were given a single oral supplement of RA after olfactory nerve transection. Results demonstrate that RA accelerates the recovery of olfactory functions after injury.
Yee
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Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104-3308, USA.
Rawson
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NE
D000818:Animals; D003714:Denervation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009416:Nerve Regeneration / Q000187:drug effects*; D000857:Olfaction Disorders / Q000209:etiology* / Q000503:physiopathology*; D009832:Olfactory Nerve / Q000503:physiopathology*; D009833:Olfactory Pathways / Q000503:physiopathology*; D012903:Smell / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin