title: Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy.
abstract: Congenital afibrinogenaemia and hypofibrinogenaemia are rare disorders of haemostasis. In this case report the problems posed in the management of two patients with fibrinogen levels less than 0.1g L(-1) and who developed intracranial bleeding are considered. The value of fibrinogen concentrate and the role of prophylaxis is also discussed.
authors: Haemophilia Centre, St Bartholomew's and The London NHS Trust, Royal London Hospital, London, UK.
authors: R
authors: R
authors: Parameswaran
authors: J P
authors: JP
authors: Dickinson
authors: S
authors: S
authors: de Lord
authors: D M
authors: DM
authors: Keeling
authors: B T
authors: BT
authors: Colvin
mesh_terms: D000328:Adult; D000347:Afibrinogenemia / Q000150:complications* / Q000151:congenital / Q000628:therapy; D005340:Fibrinogen / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008297:Male
chemical_list: D005340:Fibrinogen