title: Female urethral adenocarcinoma arising from urethritis glandularis.
abstract: BACKGROUND
  Female urethral adenocarcinoma is extremely rare and more than one tissue of origin has been suggested other than the Skene's gland. Immunohistochemistry with cytokeratins (CK) 7 and 20 is used to define the origin of the tumor.
  
  
  METHODS
  A 72-year-old woman presented with a 2-cm polypoid tumor at the external urethral meatus and bleeding. Wide local excision and bilateral inguinal lymphadenectomy were performed. Postoperative convalescence was uneventful. It was a poorly differentiated mucinous adenocarcinoma without direct urothelial involvement. There were focal areas of intestinal metaplasia. The tumor cells were positive for CK 7 and 20 and negative for prostate-specific antigen.
  
  
  CONCLUSIONS
  This case provides supportive evidence that mucinous urethral adenocarcinoma may arise from malignant transformation of urethritis glandularis.
authors: Department of Obstetrics and Gynecology, University of Hong Kong, Hong Kong SAR, China.
authors: Y M
authors: YM
authors: Chan
authors: D
authors: D
authors: Ka-Leung Cheng
authors: A
authors: A
authors: Nga-Yin Cheung
authors: H
authors: H
authors: Yuen-Sheung Ngan
authors: L C
authors: LC
authors: Wong
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000378:metabolism; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins / Q000378:metabolism; D014523:Urethral Neoplasms / Q000209:etiology* / Q000378:metabolism; D014526:Urethritis / Q000150:complications*
chemical_list: D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; C507499:KRT20 protein, human; C507497:KRT7 protein, human; D053554:Keratin-20; D053552:Keratin-7; D007633:Keratins