Susceptibility and resistance to Trypanosoma congolense infections.
We have put emphasis on recent findings in experimental Trypanosoma congolense infections in highly susceptible BALB/c and relatively resistant C57Bl/6 mice. Based on various analyses, it has been shown that a major difference in resistance to T. congolense infections is expressed early in infection at the macrophage level. A novel plastic-adherent Thy1.2(+) suppressor lymphocyte, which in absolute synergy with a Thy 1.2(-) cell exerts its suppression via interleukin-10 and interferon-gamma opens up an exciting new field of research.
Tabel
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Department of Veterinary Microbiology, University of Saskatchewan, SK, S7N 5B4, Saskatoon, Canada. tabel@sask.usask.ca
Kaushik
R S
RS
Uzonna
J E
JE
D000818:Animals; D016207:Cytokines / Q000276:immunology; D006790:Host-Parasite Interactions; D007110:Immunity, Active; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D007371:Interferon-gamma / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D008211:Lymphocyte Cooperation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014348:Trypanosoma congolense; D014353:Trypanosomiasis, African / Q000276:immunology* / Q000469:parasitology
D016207:Cytokines; D016753:Interleukin-10; D007371:Interferon-gamma