Pathologic rupture of the spleen during induction with ATRA in a patient with acute promyelocytic leukemia.
Pathological rupture of the spleen is a rare but well recognized complication in hematological malignancies. Early clinical recognition of this life-threatening complication is necessary for rapid intervention. Here, we report on the case of a 26-year-old woman with acute promyelocytic leukemia who presented rupture of the spleen on day +2 of treatment with ATRA plus idarrubicin. In patients with acute leukemia, the presence of a painful abdomen and a sudden drop in hemoglobin levels, should alert of a possible splenic rupture, even without additional symptoms. This would facilitate an early treatment intervention with no modification to the chemotherapy schedule.
Hernández
R
R
Servicio de Hematología, Hospital Universitario de Salamanca, Spain. robert-69@medicosmix.com
del Cañizo
M C
MC
López
C
C
González
M I
MI
Vázquez
M L
ML
Caballero
M D
MD
San Miguel
J F
JF
D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000188:drug therapy; D012422:Rupture, Spontaneous; D013161:Splenic Rupture / Q000175:diagnosis / Q000209:etiology*; D014212:Tretinoin / Q000008:administration & dosage
D014212:Tretinoin; D015255:Idarubicin