Effects of amrinone on ischaemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1.
The effects of amrinone, a selective phosphodiesterase III inhibitor, on liver ischaemia reperfusion injury have not yet been clarified. Forty-five patients with hepatocellular carcinoma who underwent partial liver resection using Pringle's manoeuvre were studied. Patients were divided into three groups: those given amrinone, those given prostaglandin E1 (PGE1) and those not treated (controls). An indocyanine green (ICG) clearance test was performed before the operation and three times during surgery: just before induction of liver ischaemia, just after liver resection and 60 min after reperfusion. Blood lactate and base excess were measured at the same times. Systolic and diastolic arterial pressure, heart rate, cardiac index and oesophageal temperature were monitored. Aminotransferase levels were recorded the day before surgery, 1 h after operation and on the first and third postoperative days. These data were compared between groups. The ICG elimination rate, lactate and base excess in the amrinone group differed significantly from those in controls during the observation period (P = 0.03, P = 0.04 and P = 0.03, respectively). The differences between the PGE1 and control groups were not significant. There were no significant differences between the groups in perioperative vital signs, cardiac index or postoperative aminotransferase. Amrinone enhanced intraoperative ICG elimination in cirrhotic patients who underwent liver resection.
Orii
R
R
Department of Anaesthesiology, University of Tokyo, Japan.
Sugawara
Y
Y
Hayashida
M
M
Yamada
Y
Y
Chang
K
K
Takayama
T
T
Makuuchi
M
M
Hanaoka
K
K
D000368:Aged; D000527:Alprostadil / Q000627:therapeutic use; D000676:Amrinone / Q000627:therapeutic use*; D000704:Analysis of Variance; D005260:Female; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000378:metabolism / Q000601:surgery; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism
D010726:Phosphodiesterase Inhibitors; D010975:Platelet Aggregation Inhibitors; D019344:Lactic Acid; D000527:Alprostadil; D007208:Indocyanine Green; D000676:Amrinone