[Toxigenic Vibrio cholerae non-01].
The antimicrobial susceptibility and the presence of a heat-stable toxin were researched into 100 non-01 Vibrio cholerae strains sent by 7 different health centers to the National Reference Laboratory of Acute Diarrheal Diseases in "Pedro Kourí" Tropical Medicine Institute. The presence of 20% toxigenic non-01 Vibrio cholerae was detected, a figure substantially higher than that reported in other geographic areas, except for endemic areas. This result will make it possible to set epidemiological alert in Cuba because these strains can be infected by CTX phages (element transporting genes that encode for choleric toxin) which will give such strains an epidemic potential similar to that of the etiologic agent of cholera. The identified strains could be studied as possible cholera vaccine candidates.
Bravo
L
L
Instituto de Medicina Tropical Pedro Kourí, Marianao, Ciudad de la Habana, Cuba. ipk@ciipk.sld.cu
Ramírez
M
M
Maestre
J L
JL
Llop
A
A
Cabrera
R
R
García
B
B
Fernández
A
A
Castañeda
N
N
D000818:Animals; D015373:Bacterial Typing Techniques; D002675:Child, Preschool; D002772:Cholera Toxin / Q000032:analysis / Q000302:isolation & purification*; D003462:Cuba; D005243:Feces / Q000382:microbiology; D006801:Humans; D007223:Infant; D051379:Mice; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D012703:Serotyping; D014734:Vibrio cholerae / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity
D002772:Cholera Toxin