title: Polymer-supported tetrafluorophenol: a new activated resin for chemical library synthesis.
abstract: A new tetrafluorophenol activated resin that facilitates the use of 19F NMR to quantitate loading is presented. This new resin provides a useful tool for acylation, and a novel activated polymeric sulfonate ester to generate sulfonamides. This activated resin reacts with a wide scope of N-nucleophiles including primary and secondary amines, and anilines. This new activated resin methodology provides a powerful tool for pure single-compound library synthesis.
authors: Lead Discovery Department, Rhone Poulen Rorer, Collegeville, Pennsylvania 19426, USA.
authors: J M
authors: JM
authors: Salvino
authors: N V
authors: NV
authors: Kumar
authors: E
authors: E
authors: Orton
authors: J
authors: J
authors: Airey
authors: T
authors: T
authors: Kiesow
authors: K
authors: K
authors: Crawford
authors: R
authors: R
authors: Mathew
authors: P
authors: P
authors: Krolikowski
authors: M
authors: M
authors: Drew
authors: D
authors: D
authors: Engers
authors: D
authors: D
authors: Krolikowski
authors: T
authors: T
authors: Herpin
authors: M
authors: M
authors: Gardyan
authors: G
authors: G
authors: McGeehan
authors: R
authors: R
authors: Labaudiniere