Acute myelomonocytic leukaemia with pseudo-Chediak-Higashi inclusions in leukaemic blasts report of an unusual case.
Giant inclusions in the blast cells resembling that of Chediak-Higashi syndrome have been reported only in a handful of cases with acute leukaemia. There is a paucity of data on the ultrastructural appearance of such unique light microscopic findings. As many of such patients were reported in late seventies and early eighties [1-4] the outcome of treatment using present day multiple induction/consolidation regimens in such patients has also been rarely reported due to the rarity of such patients. We report here on a patient with acute myeloid leukaemia showing pseudo-Chediak-Higashi inclusions in leukaemic blasts with unusual ultrastructural morphology.
Ghosh
K
K
Department of Haematology, Sultan Qaboos University, Muscat, Sultanate of Oman. kanjakshaghosh@hotmail.com
Khanduri
U
U
Hiwase
D
D
Venugopal
S
S
Muirhead
D
D
D000293:Adolescent; D005260:Female; D006801:Humans; D002479:Inclusion Bodies; D015479:Leukemia, Myelomonocytic, Acute / Q000473:pathology*; D007962:Leukocytes / Q000473:pathology / Q000648:ultrastructure