[Effects of bemethyl, ethomersol, and yakton on the liver regeneration after partial hepatectomy].
It is experimentally demonstrated for the first time that the new drugs bemithyl, etomerzol, and yakton are capable of accelerating the process of liver regeneration following partial hepatectomy. The drugs produce a hasty gain in the mass of liver, increase in the content of nucleic acids and glycogen, and improve the functional state, as manifested by a decrease in the blood bilirubin and a reduction in the hexenal sleep duration. Bemithyl, etomerzol, and yakton produce a positive effect upon the liver morphology and the intracellular regeneration process. The repair activity of the new drugs exceeds that of a combination of the well-known regeneration stimulants riboxin and potassium orotate, representing derivatives of purine and pyrimidine bases.
Gaĭvoronskaia
V V
VV
Department of Pharmacology, St. Petersburg Military Medical Academy, Russia.
Okovityĭ
S V
SV
Shustov
E B
EB
Smirnov
A V
AV
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats
D001562:Benzimidazoles; C417230:yakton; C070941:ethomersol; C049825:bemethyl