title: AB(5) toxins: structures and inhibitor design.
abstract: High-resolution crystal structures of AB(5) toxins in their native form or in complex with a variety of ligands have led to the structure-based design and discovery of inhibitors targeting different areas of the toxins. The most significant progress is the development of highly potent multivalent ligands that block binding of the toxins to their receptors.
authors: Department of Biological Structure, Biomolecular Structure Center, WA Seattle, WA 98195, USA.
authors: E
authors: E
authors: Fan
authors: E A
authors: EA
authors: Merritt
authors: C L
authors: CL
authors: Verlinde
authors: W G
authors: WG
authors: Hol
mesh_terms: D001427:Bacterial Toxins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D015195:Drug Design; D008565:Membrane Proteins / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D001427:Bacterial Toxins; D008565:Membrane Proteins