Runt and Lozenge function in Drosophila development.
Runt and Lozenge (LZ) are members of the Runt domain family of transcriptional regulators and control a large number of developmental processes in Drosophila. Runt is a pair-rule gene, and is part of the network of genes that control pattern formation in the embryo. In the central nervous system, Runt function is necessary for the development of a subset of neurons. Runt is also a key regulator of sex determination, and directly controls Sex-lethal, a master gene that determines sex of the animal and controls dosage compensation. The LZ protein also participates in several key processes. LZ controls pre-patterning and cell-fate choices in the development of the visual system by regulating the expression of several fate-specifying transcription factors, and works in conjunction with general signaling pathways. LZ function is also required in hematopoiesis for the specification of a Drosophila blood cell lineage.
Canon
J
J
Department of Biological Chemistry, Molecular Biology Institute, University of California at Los Angeles, 90095, USA.
Banerjee
U
U
D000818:Animals; D019521:Body Patterning / Q000235:genetics* / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics / Q000254:growth & development*; D005123:Eye / Q000196:embryology / Q000254:growth & development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008297:Male; D009687:Nuclear Proteins; D019849:Sex Determination Processes; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C099964:lz protein, Drosophila; C080833:run protein, Drosophila