Immunity against Helicobacter pylori: significance of interleukin-4 receptor alpha chain status and gender of infected mice.
Vaccination of interleukin-4 (IL-4) receptor alpha (IL-4Ralpha) chain-deficient BALB/c mice with Helicobacter pylori urease and cholera toxin or with urease-expressing, live attenuated Salmonella enterica serovar Typhimurium cells revealed that protection against H. pylori infection is independent of IL-4- or IL-13-mediated signals. A comparison of male and female mice suggests a sexual dimorphism in the extent of bacterial colonization that is particularly evident in the absence of the IL-4Ralpha chain.
Aebischer
T
T
Department of Molecular Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany. aebischer@mpiib-berlin.mpg.de
Laforsch
S
S
Hurwitz
R
R
Brombacher
F
F
Meyer
T F
TF
D000818:Animals; D002772:Cholera Toxin / Q000276:immunology; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D018793:Interleukin-13 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D019948:Receptors, Interleukin-4 / Q000502:physiology*; D012727:Sex Characteristics; D014510:Urease / Q000276:immunology; D014611:Vaccination
D018793:Interleukin-13; D019948:Receptors, Interleukin-4; D015847:Interleukin-4; D002772:Cholera Toxin; D014510:Urease