title: Double-blind clonazepam vs placebo in panic disorder treatment.
abstract: OBJECTIVE
  To assess the effectiveness of clonazepam, in a fixed dose (2 mg/day), compared with placebo in the treatment of panic disorder patients.
  
  
  METHODS
  24 panic disorder patients with agoraphobia were randomly selected. The diagnosis was obtained using the structured clinical interview for DSM-IV. All twenty-four subjects were randomly assigned to either treatment with clonazepam (2 mg/day) or placebo, during 6 weeks. Efficacy assessments included: change from baseline in the number of panic attacks; CGI scores for panic disorder; Hamilton rating scale for anxiety; and panic associated symptoms scale.
  
  
  RESULTS
  At the therapeutic endpoint, only one of 9 placebo patients (11.1%) were free of panic attacks, compared with 8 of 13 (61.5%) clonazepam patients (Fisher exact test; p=0,031).
  
  
  CONCLUSIONS
  the results provide evidence for the efficacy of clonazepam in panic disorder patients.
authors: Laboratory of Panic & Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Brazil. avalen@uol.com.br
authors: A M
authors: AM
authors: Valença
authors: A E
authors: AE
authors: Nardi
authors: I
authors: I
authors: Nascimento
authors: M A
authors: MA
authors: Mezzasalma
authors: F L
authors: FL
authors: Lopes
authors: W
authors: W
authors: Zin
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy*; D000704:Analysis of Variance; D002998:Clonazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D018757:GABA Modulators / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000188:drug therapy*
chemical_list: D018757:GABA Modulators; D002998:Clonazepam