The vaccine origin of the 1968 epidemic of type 3 poliomyelitis in Poland.
A clear association was demonstrated between the use of USOL-D-bac type 3 poliovirus live-attenuated vaccine and the 1968 poliomyelitis epidemic in Poland. The epidemic followed small-scale trials with Sabin and USOL-D-bac type 3 vaccine strains carried out in seven countries including Poland. Factors that might have contributed to the genesis and development of the epidemic were the pattern of virus excretion from vaccinees, mutations found in viruses from the epidemic, and the particular vaccination policies in Poland during the previous years. These findings may provide essential insights into the strategies for stopping polio immunisation once wild poliovirus has been eradicated.
Martín
J
J
Division of Virology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire EN6 3QG, United Kingdom. jmartin@nibsc.ac.uk
Ferguson
G L
GL
Wood
D J
DJ
Minor
P D
PD
D000956:Antigens, Viral / Q000235:genetics; D004196:Disease Outbreaks; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D011044:Poland / Q000453:epidemiology; D011051:Poliomyelitis / Q000453:epidemiology / Q000821:virology*; D017955:Poliovirus / Q000145:classification* / Q000235:genetics; D023321:Poliovirus Vaccines / Q000009:adverse effects* / Q000235:genetics; D020539:Sequence Analysis, Protein; D014613:Vaccines, Attenuated / Q000009:adverse effects* / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
D000956:Antigens, Viral; D023321:Poliovirus Vaccines; D014613:Vaccines, Attenuated; D014764:Viral Proteins