title: Venodilatory effect of pranidipine, a calcium channel blocker, monitored with perfluorocarbon in vivo (19)F-NMR spectroscopy.
abstract: We previously reported that the (19)F-NMR signal intensity of perfluorocarbon was increased by a venodilator, nitroglycerine, and decreased by an arteriodilator, hydralazine. In the present study, we demonstrated that pranidipine, a calcium channel blocker, increased the intensity of the FC-43 signal, while nifedipine, a prototype of calcium channel blockers, did not. These results suggest that pranidipine dilates the venous system in contrast to nifedipine.
authors: Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10, Kagasuno, Kawauchi-cho, Tokushima 771-0192, Japan. sogabet@noken.otsuka.co.jp
authors: T
authors: T
authors: Sogabe
authors: T
authors: T
authors: Mori
authors: M
authors: M
authors: Ohura
authors: M
authors: M
authors: Tominaga
authors: K
authors: K
authors: Koga
authors: Y
authors: Y
authors: Yabuuchi
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004095:Dihydropyridines / Q000494:pharmacology*; D005461:Fluorine; D005466:Fluorocarbons; D006439:Hemodynamics; D017078:Laser-Doppler Flowmetry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014665:Vasodilator Agents; D014680:Veins / Q000187:drug effects*
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D005466:Fluorocarbons; D014665:Vasodilator Agents; D005461:Fluorine; C048161:pranidipine; D009543:Nifedipine