[Immunomodulating effects of vitamin K preparations and its potentiation by riboxine in acute cold stress].
The vitamin K preparations phylloquinone, menadione, and vikasol produce an immunomodulant effect under acute cold-induced stress conditions. A combination of phylloquinone, menadione and riboxin provides an effective means of correcting the immunological reactivity and antioxidant state under the conditions of immersion cooling. The immunomodulant effect of naphthoquinones and riboxin is correlated with their antioxidant activty.
Bystrova
N A
NA
Biochemistry Department, Kursk State Medical University, Russia.
Brovkina
I L
IL
Prokopenko
L G
LG
Uteshev
B S
BS
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D003080:Cold Temperature; D004357:Drug Synergism; D007101:Immersion; D007290:Inosine Diphosphate / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012756:Sheep; D013312:Stress, Physiological / Q000276:immunology* / Q000378:metabolism; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010837:Vitamin K 1 / Q000494:pharmacology*; D024483:Vitamin K 3
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D014812:Vitamin K; D024483:Vitamin K 3; D010837:Vitamin K 1; D007290:Inosine Diphosphate