Reemergence of tardive dyskinesia after discontinuation of clozapine treatment.
Tardive dyskinesia (TD) continues to be a significant health problem and a serious limitation to neuroleptic medication treatment. Clozapine treatment may reduce the severity of TD but it is unclear wether the medication temporarily suppresses symptoms or leads to a sustain resolution of the disorder. Herein we describe two cases with severe TD which clozapine had to be discontinued. These cases suggest that clozapine provides a temporary suppression of TD rather than a permanent resolution of the disorder.
Yovtcheva
S P
SP
University of Virginia School of Medicine, Roanoke Salem Psychiatric Medicine Residency Program, Department of Psychiatry (116A7), VA Medical Center, Salem, VA 24153, USA. yovtcheva.sonia_r@salem.va.gov
Stanley-Tilt
C
C
Moles
J K
JK
D000368:Aged; D003024:Clozapine / Q000627:therapeutic use*; D004409:Dyskinesia, Drug-Induced / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013997:Time Factors
D012702:Serotonin Antagonists; D003024:Clozapine