Cyclo(dehydroala-L-Leu), an alpha-glucosidase inhibitor from Penicillium sp. F70614.
A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast alpha-glucosidase and porcine intestinal alpha-glucosidase with IC50 values of 35 and 50 microg/ml, respectively. However, it did not show significant inhibitory effects against almond beta3-glucosidase, Aspergillus alpha-galactosidase, Escherichia coli beta-galactosidase and jack bean alpha-mannosidase.
Kwon
O S
OS
Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon.
Park
S H
SH
Yun
B S
BS
Pyun
Y R
YR
Kim
C J
CJ
D001667:Binding, Competitive; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D065089:Glycoside Hydrolase Inhibitors; D020128:Inhibitory Concentration 50; D010407:Penicillium / Q000737:chemistry* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010879:Piperazines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000520:alpha-Glucosidases / Q000378:metabolism
C417142:Cyclo(dehydroala-Leu); D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010456:Peptides, Cyclic; D010879:Piperazines; D000520:alpha-Glucosidases