Immunohistochemical localization of plasminogen activator inhibitor-1 in rat and human brain tissues.
We investigated immunohistochemically the localization of type 1 plasminogen activator inhibitor (PAI-1) in rat and human brain tissues. In rat, neurons and astrocytes were stained positively for PAI-1 after colchicine treatment. In post-mortem human brain, neurons were stained for PAI-1 but the number of positive neurons varied greatly from case to case. PAI-1 positive astrocytes occurred in the white matter lesions of some patients. In Alzheimer's disease, weak PAI-1 labeling was seen in association with senile plaques and ghost tangles. The present results support a notion that PAI-1 and its target proteases such as plasminogen activators and thrombin are involved in a variety of physiological and pathological processes in brain.
Hino
H
H
Department of Psychiatry, Yokohama City University, School of Medicine, Yokohama, Japan.
Akiyama
H
H
Iseki
E
E
Kato
M
M
Kondo
H
H
Ikeda
K
K
Kosaka
K
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000818:Animals; D000906:Antibodies; D001253:Astrocytes / Q000737:chemistry; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D005342:Fibrinolysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000737:chemistry / Q000473:pathology; D009474:Neurons / Q000737:chemistry; D058225:Plaque, Amyloid / Q000737:chemistry / Q000473:pathology; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis* / Q000276:immunology; D051381:Rats
D000906:Antibodies; D017395:Plasminogen Activator Inhibitor 1