The evaluation of false negative mammography from malignant and benign breast lesions.
Preoperative mammograms from 395 breast cancers and 132 benign breast lesions were enrolled for this study. The false-negative (FN) rate for breast cancers from preoperative reading was 9.6% with 38 breast cancers missed on mammograms. The statistically significant differences occurred between true-positive (TP) and FN cancers for younger age (P<.025), smaller lesion size (P<.001), denser breast (P<.05), deep retroglandular location (P<.001). None of the FN cancers exhibited calcifications. The FN rate for mammography for benign breast lesions from preoperative reading was 18.9% with 25 lesions misdiagnosed. The statistically significant difference between benign TP and FN lesions occurred for central and subareolar location (P<.025). Exploration of possible factors and imaging features in FN mammograms can help reduce the FN rate for mammography.
Wang
J
J
Department of Medical Imaging, National Taiwan University Hospital, 7 Chung-Shan South Road, 100, Taipei, Taiwan.
Shih
T T
TT
Hsu
J C
JC
Li
Y W
YW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001941:Breast Diseases / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D016009:Chi-Square Distribution; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D012189:Retrospective Studies