Identification of a genetic subcluster of HIV type 1 subtype C (C') widespread in Ethiopia.
Others and we have previously shown that subtype C is the predominant HIV-1 subtype and the major cause of AIDS in Ethiopia. The present study shows that subtype C in Ethiopia has a genetic subcluster, designated C', has not increased in frequency, or spread geographically, over the period 1988 (%C' = 23/53) to 1996-1997 (%C' = 26/50). There is no association of the HIV-1 subtype C or subcluster C' with geographic location, time of sample collection, or risk group in Ethiopia. Of 105 randomly collected samples representing 7 different towns in Ethiopia, all but 2 (1 subtype A from Addis Ababa, 1997 and 1 subtype D from Dessie, 1996) belong to subtype C.
Abebe
A
A
Ethiopian-Netherlands AIDS Research Project (ENARP) at the Ethiopian Health and Nutrition Research Institute (EHNRI), Addis Ababa. enarp@telecom.net.et
Pollakis
G
G
Fontanet
A L
AL
Fisseha
B
B
Tegbaru
B
B
Kliphuis
A
A
Tesfaye
G
G
Negassa
H
H
Cornelissen
M
M
Goudsmit
J
J
Rinke de Wit
T F
TF
D000595:Amino Acid Sequence; D005002:Ethiopia / Q000453:epidemiology; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology; D010802:Phylogeny; D017422:Sequence Analysis, DNA
D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments