Effects of methamphetamine-induced neurotoxicity on the development of neural circuitry: a hypothesis.
Exposure of the developing brain to methamphetamine has well-studied biochemical and behavioral consequences. We review: (1) the effects of methamphetamine on mature serotonergic and dopaminergic pathways; (2) the mechanisms of methamphetamine neurotoxicity and (3) the role of serotonergic and dopaminergic signaling in sculpting developing neural circuitry. Consideration of these data suggest the types of neural circuit alterations that may result from exposure of the developing brain to methamphetamine and that may underlie functional defects.
Frost
D O
DO
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 West Baltimore St., Baltimore, MD 21201, USA. dfrost@umaryland.edu
Cadet
J L
JL
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D008694:Methamphetamine / Q000633:toxicity*; D008959:Models, Neurological; D009415:Nerve Net / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D009498:Neurotoxins / Q000633:toxicity*; D012701:Serotonin / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects
D009498:Neurotoxins; D012701:Serotonin; D008694:Methamphetamine; D004298:Dopamine