title: Acute retrovirus syndrome among prospectively identified homosexual men with incident HIV infection in Brazil. Projecto Praça Onze Study Group.
abstract: BACKGROUND
  Symptoms associated with HIV infection are common among HIV seroconverters, but the acute retroviral syndrome (ARS) is a diagnostic challenge because of the absence of a sensitive and specific case definition. We conducted an analysis of HIV seroconverters in Projeto Praça Onze, a HIVNET HIV seroincidence study among homosexual men in Rio de Janeiro.
  
  
  METHODS
  Information from study subjects enrolled in Projeto Praça Onze who were documented HIV seroconverters were compared with nonseroconverters. At each semiannual study visit, participants were asked about HIV seroconversion symptoms and sexually transmitted diseases (STDs) during the preceding 6 months. All information was collected before the laboratory evaluation. A classification tree analysis was used to identify an ARS case definition, first using clinical information and then after including risk factor data for seroconversion in our cohort.
  
  
  RESULTS
  As of July 1998, 674 volunteers were enrolled and 34 of these seroconverted; information was available for 33 of these. Among the seroconverters, 11 (34%) denied any symptoms, and 22 (66%) reported one or more symptoms, the most common of which were fever (25% of seroconverters versus 7% of nonseroconverters; p <.01), night sweats (9% versus 2%, respectively; p =.05), incapacitating disease (ID) for >/=3 days (27% versus 7%, respectively; p <.001), and weight loss of >/=2 kg (21% versus 9%, respectively; p =.05). STDs were more common in seroconverters (gonorrhea: 9% versus 1%, respectively; p <.01 and condyloma: 9% versus 3%, respectively; p =. 08). The first case definition was ID for >3 days, fever, pharyngitis, and myalgia (seroconverters, 3 of 32, versus nonseroconverters, 2 of 640). The second case definition was was ID for >3 days, anti-core hepatitis b-positive, and age <21 years (seroconverters: 6 of 32 versus nonseroconverters 4 of 640). The sensitivity and specificity for the first and second case definitions were: 9.4%, 99.4%, and 18.8%, 99.8%, respectively.
  
  
  CONCLUSIONS
  Among HIV seroconverters, symptoms consistent with ARS were common. We were unable to identify a sensitive case definition that could be used as a screening tool. Although the clinical case definition was not validated, the specificity of our case definitions was high, suggesting that subjects within this HIV risk group who fulfill the case definition should be tested for HIV.
authors: Infectious Diseases Service, Hospital Universitário Clementino Fraga Filho, Department of Preventive Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors: C B
authors: CB
authors: Hofer
authors: L H
authors: LH
authors: Harrison
authors: C J
authors: CJ
authors: Struchiner
authors: R I
authors: RI
authors: Moreira
authors: R F
authors: RF
authors: do Lago
authors: M F
authors: MF
authors: de Melo
authors: M
authors: M
authors: Schechter
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001938:Brazil / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis*; D006679:HIV Seropositivity / Q000150:complications / Q000175:diagnosis*; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012749:Sexually Transmitted Diseases / Q000175:diagnosis; D013577:Syndrome