title: [Effect of ammonium succinate on pharmacological effects of acetylsalicylic acid].
abstract: Ammonia succinate potentiates the main pharmacological properties and reduces the toxic effects (ulcerogenic action and general toxicity) of acetylsalicylic acid. The new preparation astam, representing a combination of acetylsalicylic acid with ammonia succinate in a 2:1 ratio, is proposed. Astam exhibits antiexudative, capillary-reinforcing, antiproliferative, pain-relieving, antipyretic, antiaggregant, and antioxidant properties. In addition, the drug inhibits the development of structural-metabolic disorders in the case of chronic immune inflammation of joints and various internal organs.
authors: Pharmacology Department, Siberian Medical University, Tomsk, Russia.
authors: A S
authors: AS
authors: Saratikov
authors: A P
authors: AP
authors: Bulatnikov
authors: A I
authors: AI
authors: Vengerovskiĭ
authors: T P
authors: TP
authors: Prishchep
authors: L A
authors: LA
authors: Sibileva
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000139:chemically induced; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D019802:Succinic Acid / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D023382:Toxicity Tests, Acute
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; C469372:aspirin, succinic acid drug combination; D019802:Succinic Acid; D001241:Aspirin