Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake.
High-density lipoproteins (HDL) play an important role in protection against atherosclerosis by mediating reverse cholesterol transport - the transport of excess cholesterol from peripheral tissues to the liver for disposal. SR-BI is a cell surface receptor for HDL and other lipoproteins (LDL and VLDL) and mediates the selective uptake of lipoprotein cholesterol by cells. Overexpression or genetic ablation of SR-BI in mice revealed that it plays an important role in HDL metabolism and reverse cholesterol transport and protects against atherosclerosis in mouse models of the disease. If it plays a similar role in humans then it may be an attractive target for therapeutic intervention. We will review some of the recent advances in the understanding of SR-BI's physiological role and cellular function in lipoprotein metabolism.
Trigatti
B L
BL
Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. trigatt@mcmaster.ca
Rigotti
A
A
Braun
A
A
D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001692:Biological Transport; D018955:CD36 Antigens / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D053480:Cholesterol Ester Transfer Proteins; D003324:Coronary Artery Disease / Q000378:metabolism*; D004195:Disease Models, Animal; D006023:Glycoproteins; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008565:Membrane Proteins; D051379:Mice; D008822:Mice, Transgenic; D008956:Models, Chemical; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein / Q000235:genetics / Q000378:metabolism*; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D013379:Substrate Specificity
D001053:Apolipoproteins; D018955:CD36 Antigens; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008075:Lipoproteins, HDL; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B