title: Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium.
abstract: Further study on the chloroform-soluble portion of the root bark of Zanthoxylum schinifolium led to the isolation of eight new coumarins: methylschinilenol (1), hydroxyepoxycollinin I (2), 8-methoxyanisocoumarin H (3), hydroxyschininallylol (4), hydroxyepoxycollinin II (5), schinitrienin (6), schininallylone (7), and isoschinilenol (8), along with twenty-six known compounds including fourteen coumarins, and nine alkaloids. The structural elucidation was determined by spectroscopic data. Among the isolates, terpenyl-coumarins and furoquinolines were the active constituents with antiplatelet aggregation in vitro and collinin (10) showed significant anti-HBC DNA replication activity.
authors: School of Pharmacy, Kaohsiung Medical University, Taiwan, R.O.C.
authors: I L
authors: IL
authors: Tsai
authors: W Y
authors: WY
authors: Lin
authors: C M
authors: CM
authors: Teng
authors: T
authors: T
authors: Ishikawa
authors: S L
authors: SL
authors: Doong
authors: M W
authors: MW
authors: Huang
authors: Y C
authors: YC
authors: Chen
authors: I S
authors: IS
authors: Chen
mesh_terms: D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D018517:Plant Roots / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D019685:Rosales / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D003374:Coumarins; D010975:Platelet Aggregation Inhibitors