Evaluation of solvent/detergent-treated plasma in patients with a prolonged prothrombin time.
OBJECTIVE
To compare the laboratory and clinical outcome of patients who received solvent/detergent-treated plasma (SDP) and fresh-frozen plasma (FFP).


METHODS
A randomized, double-blinded study to assess the ability of SDP and FFP to reduce a prolonged prothrombin time (PT) to </=15 s in patients with acquired coagulation deficits.


RESULTS
45 patients (22 SDP vs. 23 FFP) were treated with 71 infusions. There were no significant differences in mean dose of plasma infused (7.8 ml/kg for SDP vs. 8.0 ml/kg for FFP, p = 0.46), percentage of patients who corrected their PT to </=15 s (32% for SDP vs. 26% for FFP, p = 0.67), or percentage of patients whose bleeding ceased (27% for SDP vs. 22% for FFP).


CONCLUSIONS
No clinical or statistically significant differences were observed after infusion with SDP or FFP in patients with acquired coagulation deficits.
Lerner
R G
RG
Hematology Section, Department of Medicine, Valhalla, N.Y., USA.
Nelson
J
J
Sorcia
E
E
Grima
K
K
Kancherla
R R
RR
Zarou-Naimo
C M
CM
Pehta
J C
JC
D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors / Q000187:drug effects*; D001803:Blood Transfusion; D003902:Detergents / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology / Q000517:prevention & control; D006474:Hemorrhagic Disorders / Q000097:blood* / Q000628:therapy; D006801:Humans; D017053:Infection Control / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000187:drug effects*; D011517:Prothrombin Time; D012449:Safety; D012997:Solvents / Q000494:pharmacology*; D014777:Virus Diseases / Q000517:prevention & control* / Q000635:transmission; D014780:Viruses / Q000187:drug effects*
D001779:Blood Coagulation Factors; D003902:Detergents; D012997:Solvents