4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain.
Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine (1) from the culture broth of a marine Micromonospora sp. (strain L-31-CLCO-002). The fermentation, structural data and cytotoxic activities of these compounds against various tumor cell lines are given.
Hernández
L M
LM
Instituto Biomar S.A., Pol. Ind., León, Spain.
Blanco
J A
JA
Baz
J P
JP
Puentes
J L
JL
Millán
F R
FR
Vázquez
F E
FE
Fernández-Chimeno
R I
RI
Grávalos
D G
DG
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008847:Micromonospora / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D019311:Staurosporine / Q000031:analogs & derivatives; D014407:Tumor Cells, Cultured; D014871:Water Microbiology
C417109:4'-N-methyl-5'-hydroxystaurosporine; C417110:5'-hydroxystaurosporine; D000470:Alkaloids; D000970:Antineoplastic Agents; D002227:Carbazoles; D007211:Indoles; D019311:Staurosporine