[Approaches to prediction of gastropathy development risk due to non-steroidal antiinflammatory drugs].
OBJECTIVE
Examination of gastric secretion in rheumatoid arthritis (RA) patients and its response to sodium diclophenak and indomethacine.


METHODS
46 RA patients entered the study. All of them have been long on nonsteroid antiinflammatory drugs (NAID). Two groups of patients were analysed: group 1--free of NAID gastropathy, group 2--with NAID gastropathy. pH was followed by Gastroscan system.


RESULTS
The analysis of 24-h pH-grams in both groups when NAID were not taken showed that in NAID gastropathy acid-forming gastric function is not affected while the alkalizing function markedly declines. Indomethacine is more aggressive to upper gastrointestinal tract mucosa than sodium diclophenak.


CONCLUSIONS
Dynamic intragastric pH-metry can prognosticate the risk of NAID gastropathy.
Alekseeva
A V
AV
Murav'ev
Iu V
IuV
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D004008:Diclofenac / Q000009:adverse effects; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000009:adverse effects; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013272:Stomach Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D007213:Indomethacin