Alternative splicing of the human PTEN/MMAC1/TEP1 gene.
The human tumour suppressor gene PTEN/MMAC1/TEP1 encodes a lipid and protein phosphatase. Using RT-PCR, alternatively spliced forms of PTEN mRNA, encoding full-length PTEN and two forms of the protein truncated at the C-terminal end, were detected in normal human tissue. Cultured tumour and non-tumour cell lines show similar splicing patterns.
Sharrard
R M
RM
YCR Cancer Research Unit, Department of Biology, University of York, Heslington, York YO10 5DD, UK. rms5@york.ac.uk
Maitland
N J
NJ
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D002460:Cell Line; D016147:Genes, Tumor Suppressor; D006801:Humans; D008969:Molecular Sequence Data; D051059:PTEN Phosphohydrolase; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured; D025521:Tumor Suppressor Proteins
D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins; D010744:Phosphoric Monoester Hydrolases; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human