Human leukocyte antigen (HLA) DRB1 alleles in Kuwaiti Arabs with schizophrenia.
The frequency of human leukocyte anti- gen DRB1 alleles was determined in a cohort of 194 Kuwaiti Arabs consisting of 80 schizophrenia patients and 114 ethnically matched healthy controls, using a polymerase chain reaction-sequence specific primers method. A total of 12 DRB1 alleles were identified in this Kuwaiti cohort. A statistically significant difference was detected in the frequency of alleles DRB1(*)04 and DRB1(*)13 between the schizophrenia patients and controls. Allele frequency of DRB1(*)04 in schizophrenia patients was 14% compared with nearly 7% in controls (P = 0.028). For DRB1(*)13, the allele frequency was found to be 18% in schizophrenia patients compared with 9% in the controls (P = 0.015). For alleles, DRB1(*)03, DRB1(*)07, and DRB1(*)16 the frequency was higher in controls compared with schizophrenia patients. The frequency of DRB1(*)01, DRB1(*)08, DRB1(*)10, DRB1(*)11, and DRB1(*)15 alleles was almost identical in schizophrenia patients and controls. For the remaining alleles, the differences between the two groups were not statistically significant. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:870-872, 2000.
Haider
M Z
MZ
Clinical Genetics Group, Pediatrics Department, Faculty of Medicine, Kuwait University of Kuwait, Kuwait. haider@hsc.kuniv.edu.kw
Zahid
M A
MA
Dalal
H N
HN
Razik
M A
MA
D000328:Adult; D000368:Aged; D000483:Alleles; D018912:Arabs / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007730:Kuwait; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics*
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA