Leukaemic small cell variant anaplastic large cell lymphoma during pregnancy.
The history of a 28-year-old woman with anaplastic large cell lymphoma (ALCL) in the first trimester of her pregnancy is reported. Investigations allowed to diagnose a T-cell CD30 positive ALCL, which appearance is rare during pregnancy. Moreover, the atypical lymphoid cells were found in the peripheral blood and were predominantly small to medium sized with nuclear irregularities and cytoplasmic azurophilic granules, which allowed the hypothesis of leukaemic presentation of a small cell variant ALCL. A variant of the t(2:5)(p23:q35) was found [del(2)(p22)]. The patient died shortly after diagnosis.
Lesesve
J F
JF
Laboratoire d'Hématologie, Centres Hospitaliers Universitaires de Nancy et Metz, France. jf.lesesve@chu-nancy.fr
Buisine
J
J
Grégoire
M J
MJ
Raby
P
P
Lederlin
P
P
Béné
M C
MC
Froment
N
N
Labouyrie
E
E
D000328:Adult; D002872:Chromosome Deletion; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D014178:Translocation, Genetic