Is human chorionic gonadotropin useful for identifying and treating nonpalpable testis?
OBJECTIVE
We evaluated the efficacy of human chorionic gonadotropin (HCG) for identifying and treating nonpalpable testis. We then compared the cost-effectiveness of this approach to that of laparoscopy.


METHODS
We reviewed patient charts during a 15-month period and identified 51 boys (64 testes) who underwent surgery to correct cryptorchidism. There were nonpalpable testes in 17 cases and bilateral cryptorchidism in 2 for a total of 19 impalpable testes. All patients were offered a full course of HCG. Those electing hormonal treatment received intramuscular injection of 2,000 IU/m.2 HCG (maximum 1,500 IU/injection) 3 times weekly for 3 weeks.


RESULTS
A full course of HCG was given in 8 patients (10 testes). Of the 10 testes 8 became palpable after HCG treatment, including 1 atrophic nubbin located in the inguinal canal. Of the 2 testes that remained impalpable 1 discovered at the level of the renal vessels had complete epididymal nonunion and 1 was located closer to the inguinal ring. All 9 untreated patients underwent laparoscopy, which identified 3 intra-abdominal, 3 vanished and 2 peeping testes, and 1 atrophic testis in the inguinal canal.


CONCLUSIONS
HCG therapy is valuable for identifying and treating nonpalpable testis. Using this agent enabled the testicle to be detected while avoiding the risks and cost associated with the laparoscopic procedure.
Bukowski
T P
TP
Section of Pediatric Urology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Sedberry
S
S
Richardson
B
B
D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000191:economics / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D003456:Cryptorchidism / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007273:Injections, Intramuscular; D010535:Laparoscopy; D008297:Male; D010173:Palpation; D012189:Retrospective Studies
D006063:Chorionic Gonadotropin