Quantitative analysis of structure-activity relationship in the acridine serie. Part 1: Antiparasitic 9-thioaryl-acridine derivatives.
Synthesis and antiparasitic activity vs T. cruzi and L. donovani of a series of 9-thioaryl acridines are reported. A convenient correlation between molecular structure and biological activity is proposed. Results not only agree with the classical interactions of acridines with DNA but also suggest possible role of charge transfer complexes.
Mrozek
A
A
Technical University of Łódź, 116 Zeromskiego Str., 90-924 Łódź, Poland.
Karolak-Wojciechowska
J
J
Bsiri
N
N
Barbe
J
J
D000166:Acridines / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D021281:Quantitative Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014345:Trypanosoma / Q000187:drug effects*
D000166:Acridines; D014344:Trypanocidal Agents