Novel human topoisomerase I inhibitors, topopyrones A, B, C and D. II. Structure elucidation.
The structures of novel topoisomerase I inhibitors, topopyrones A, B, C and D were elucidated by spectral analysis of the chemical derivatives. These compounds are an anthraquinone type containing a fused 1,4-pyrone moiety. Topopyrones A and B contain a chlorine atom, however C and D do not. It was suggested that topopyrones B and D are converted from topopyrones A and C, respectively by Wessely-Moser type rearrangement.
Ishiyama
D
D
Metabolism Research, Kaken Pharmaceutical Co., Ltd., Fujieda, Shizuoka, Japan.
Kanai
Y
Y
Senda
H
H
Iwatani
W
W
Iwatani
W
W
Konno
H
H
Kanazawa
S
S
D000880:Anthraquinones / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011753:Pyrones / Q000737:chemistry; D059004:Topoisomerase I Inhibitors
D000880:Anthraquinones; D004791:Enzyme Inhibitors; D011753:Pyrones; D059004:Topoisomerase I Inhibitors; C417102:topopyrone A; C417105:topopyrone B; C417104:topopyrone C; C417103:topopyrone D