Neonatal halothane anesthesia affects cortical morphology.
Neonatal cryoanesthesia has recently been documented to affect morphology and behavior after a single exposure [Dev. Brain Res. 111 (1998) 89; Horm. Behav. 37 (2000) 169]. In the current experiment, we investigated the effect of one-time exposure to halothane inhalant anesthesia on neonatal rats of both sexes. Fifteen minutes of exposure on postnatal day one resulted in detectable changes in the volume of the visual cortex at 3 months. Thus, neonatal halothane alters neural development and its effects are observable in the adult rat.
Nuñez
J L
JL
Neuroscience Program and Department of Psychology, University of Illinois at Champaign-Urbana, 603 E. Daniel Street, Champaign, IL 61820, USA.
Juraska
J M
JM
D000758:Anesthesia / Q000009:adverse effects*; D000772:Anesthesia, Local / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D008012:Lidocaine / Q000009:adverse effects; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D012727:Sex Characteristics
D018685:Anesthetics, Inhalation; D008012:Lidocaine; D006221:Halothane