title: A randomized trial comparing wireless capsule endoscopy with push enteroscopy for the detection of small-bowel lesions.
abstract: OBJECTIVE
  Wireless capsule endoscopy is a new, painless method of imaging the entire small bowel. It has not been compared with push enteroscopy. We compared the sensitivity, specificity, and safety of capsule and push enteroscopy in detecting small-bowel lesions.
  
  
  METHODS
  Nine to 13 radiopaque, colored beads (3-6 mm diameter) were sewn in random order inside 9 canine small bowels, half within the first meter, and confirmed on x-ray. After recovery, the number, order, and color of beads were assessed in 23 capsule enteroscopies and 9 push enteroscopies in a random order. The surgeons, push enteroscopists, capsule video interpreters, and pathologist were blinded to the others' findings.
  
  
  RESULTS
  The capsules identified more beads than push enteroscopy (median, 6 [range, 2-9] vs. 3 [range, 2-6 beads]; P < 0.001). The sensitivity of the capsule was 64% compared with 37% for push enteroscopy. The specificity was 92% for capsule enteroscopy and 97% for push enteroscopy. The capsules identified significantly more beads beyond the reach of the push enteroscope (median, 4 [range, 2-7] vs. 0; P < 0.0001). Hair, ingested plastic, ulceration, submucosal swelling, and worms were clearly identified by the capsule. The capsules passed safely through the animals with no significant histologic findings.
  
  
  CONCLUSIONS
  Wireless capsule endoscopy detected more abnormalities in the small bowel than push enteroscopy.
authors: Department of Gastroenterology, Royal London Hospital, London, England.
authors: M
authors: M
authors: Appleyard
authors: Z
authors: Z
authors: Fireman
authors: A
authors: A
authors: Glukhovsky
authors: H
authors: H
authors: Jacob
authors: R
authors: R
authors: Shreiver
authors: S
authors: S
authors: Kadirkamanathan
authors: A
authors: A
authors: Lavy
authors: S
authors: S
authors: Lewkowicz
authors: E
authors: E
authors: Scapa
authors: R
authors: R
authors: Shofti
authors: P
authors: P
authors: Swain
authors: A
authors: A
authors: Zaretsky
mesh_terms: D000818:Animals; D004285:Dogs; D020776:Endoscopes, Gastrointestinal; D016145:Endoscopy, Digestive System / Q000379:methods*; D004867:Equipment Design; D007410:Intestinal Diseases / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*