[Secondary osteoporosis and glucocorticoid-induced osteoporosis].
In order to assess properly the diagnosis of osteoporosis, a short clinical investigation is required to address potential causes for bone loss. Osteoporosis used to be suspected in a patient with vertebral demineralization, but nowadays it is often diagnosed in a patient with a low bone mass on a screening dual-energy X-ray absorptiometry (DEXA). In this setting, it is important for the clinician to look for secondary osteoporosis, especially in men in whom secondary osteoporosis is more frequent than in women, before discussing any specific therapy. The major causes are longterm glucocorticoid therapy, endocrine (hypogonadism, primary hyperparathyroidism, hyperthyroidism), or digestive diseases.
Orcel
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Fédération de Rhumatologie, Centre Viggo-Petersen, Hôpital Lariboisière, 6, rue Guy-Patin, 75475 Paris Cedex 10. philippe.orcel@lrb.ap-hop.fr
Krane
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SM
D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000187:drug effects; D002986:Clinical Trials as Topic; D048909:Diabetes Complications; D004066:Digestive System Diseases / Q000150:complications; D005260:Female; D050723:Fractures, Bone / Q000209:etiology; D005938:Glucocorticoids / Q000009:adverse effects*; D006620:Hip Fractures / Q000209:etiology; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications; D006980:Hyperthyroidism / Q000150:complications; D007006:Hypogonadism / Q000150:complications; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D013971:Thyrotoxicosis / Q000150:complications
D005938:Glucocorticoids