Removal of anti-A/B antibodies with plasmapheresis in ABO-incompatible kidney transplantation.
Because of a shortage of cadaver donors in Japan, ABO-incompatible living kidney transplantation has been carried out. Sixty-seven ABO-incompatible living kidney transplantations (LKT) were performed between January 1989 and December 1995 at our institution. In our previous report on the long-term results of ABO-incompatible LKT, graft survival of ABO-incompatible LKT up to 3 years was significantly lower than that of ABO-compatible LKT, but no significant difference was seen from 4 to 8 years. We removed anti-A/B antibodies by immunoadsorption and/or double filtration plasmapheresis before kidney transplantation. There was a significant difference between the anti-A/B antibody titers before and after plasmapheresis. The anti-A/B antibody titers also were well suppressed over the long term after transplantation.
Shimmura
H
H
Department of Urology, Kidney Center, Tokyo Women's Medical University, Japan. hmax.shimmura@nifty.ne.jp
Tanabe
K
K
Ishikawa
N
N
Tokumoto
T
T
Fuchinoue
S
S
Takahashi
K
K
Toma
H
H
Agishi
T
T
D000017:ABO Blood-Group System / Q000276:immunology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001787:Blood Group Incompatibility; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007518:Isoantibodies / Q000097:blood* / Q000302:isolation & purification; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis / Q000379:methods; D013997:Time Factors
D000017:ABO Blood-Group System; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D007518:Isoantibodies