Structural basis of cell-cell interactions in the immune system.
During the past year, advances in our understanding of receptor-ligand interactions between opposing cell surfaces have occurred at a structural level. These include adhesion involving CD2-CD58, antigen-specific T-cell receptor interactions with peptides bound to major histocompatibility complex molecules (both pMHCI and pMHCII), the CD8alphaalpha co-receptor-pMHCI interaction and the binding of two distinct classes of natural killer receptors to self-MHC ligands.
Wang
J
J
Dana-Farber Cancer Institute and Department of Pediatrics and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. jwang@red.dfci.harvard.edu
Reinherz
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EL
D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism; D002448:Cell Adhesion; D007107:Immune System / Q000166:cytology*; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000378:metabolism
D015703:Antigens, CD; D011948:Receptors, Antigen, T-Cell