Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication.
A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure-activity relationships of this series are discussed.
Perni
R B
RB
Avid Therapeutics, Inc., Philadelphia, PA 19104, USA. robert_perni@vpharm.com
Conway
S C
SC
Ladner
S K
SK
Zaifert
K
K
Otto
M J
MJ
King
R W
RW
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006515:Hepatitis B virus / Q000187:drug effects* / Q000502:physiology; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D001549:Benzamides; D010880:Piperidines