Genetic diversity of Pseudomonas aeruginosa strains isolated from ventilated patients with nosocomial pneumonia, cancer patients with bacteremia, and environmental water.
Random amplified polymorphic DNA typing was used to study the genetic diversity of Pseudomonas aeruginosa strains from (i) ventilated patients with nosocomial pneumonia who were hospitalized in intensive care units, (ii) cases of bacteremia in cancer patients with severe neutropenia, and (iii) rivers and swimming pools. Genetic diversity was determined by three phylogenetic methods and by statistical analysis of population genetics. The population studied undergoes epidemic clonality with a high rate of genetic recombination. P. aeruginosa bacteremia and pneumonia are not caused by specific clones within this species.
Ruimy
R
R
EPI INSERM 9933, Epidémiologie de la Résistance aux Anti-infectieux, Groupe Hospitalier Bichat-Claude Bernard, Assistance Publique Hôpitaux de Paris 75018 Paris, France.
Genauzeau
E
E
Barnabe
C
C
Beaulieu
A
A
Tibayrenc
M
M
Andremont
A
A
D016470:Bacteremia / Q000382:microbiology*; D003428:Cross Infection / Q000382:microbiology*; D014644:Genetic Variation; D006801:Humans; D015810:Linkage Disequilibrium; D009369:Neoplasms / Q000382:microbiology*; D018410:Pneumonia, Bacterial / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000235:genetics*; D019105:Random Amplified Polymorphic DNA Technique; D012121:Respiration, Artificial; D014871:Water Microbiology