Low grade fibromyxoid sarcoma. a further low-grade soft tissue malignancy characterized by a ring chromosome.
Supernumerary rings in the context of a simple karyotype characterize several low-grade malignant tumors of soft tissue and bone. Low-grade fibromyxoid sarcoma is an uncommon low-grade sarcoma, the cytogenetics of which has not yet been reported. Here we describe the first molecular-cytogenetic characterization of a pulmonary metastasis of low-grade fibromyxoid sarcoma. The histology of the primary and recurrent tumors was consistent with the diagnosis of low-grade fibromyxoid sarcoma of the usual type, whereas the pulmonary metastasis was of the "giant rosettes" variant. Cytogenetic analysis revealed a ring chromosome. Because gain of material of chromosomes 7 and 16 was detected by CGH, the ring chromosome is assumed to be composed of material from these respective chromosomes.
Mezzelani
A
A
Department of Pathology and Cytopathology, Istituto Nazionale Tumori, Via G. Venezian 1, 20133, Milan, Italy.
Sozzi
G
G
Nessling
M
M
Riva
C
C
Della Torre
G
G
Testi
M A
MA
Azzarelli
A
A
Pierotti
M A
MA
Lichter
P
P
Pilotti
S
S
D000328:Adult; D015139:Blotting, Southern; D002869:Chromosome Aberrations; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005354:Fibrosarcoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D009693:Nucleic Acid Hybridization; D012303:Ring Chromosomes; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm