Ovarian hyperstimulation and oophorectomy following accidental daily clomiphene citrate use over three consecutive months.
We describe the longest-known continuous use of clomiphene citrate ever reported in a human. As a result of a pharmacy error, a woman took 50 mg/day clomiphene citrate for three months. The prolonged use of this medication resulted in ovarian hyperstimulation and unilateral oophorectomy for torsion.
Sills
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Department of Obstetrics & Gynecology, Weill Medical College of Cornell University, The New York Presbyterian Hospital, New York, New York, USA. dr.sills@ivf.com
Poynor
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Moomjy
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D000328:Adult; D002996:Clomiphene / Q000009:adverse effects*; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects*; D020249:Hormone Replacement Therapy; D006801:Humans; D008508:Medication Errors; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced* / Q000473:pathology; D010052:Ovariectomy; D010053:Ovary / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D013974:Thyroxine / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D005300:Fertility Agents, Female; D002996:Clomiphene; D013974:Thyroxine