title: Supplemental systemic oxygen support using an intestinal intraluminal membrane oxygenator.
abstract: An intraluminal membrane oxygenator (IMO) prototype was surgically inserted in the ileum and evaluated as a method of supporting systemic oxygenation in an acutely hypoxemic porcine model. Animals were assigned randomly to the test (n = 12) or the control (n = 8) groups, which underwent identical protocols with the exception of the O2 flow in the IMO device, which was shut off in the control group. In each case, hypoxia was induced by a reduction in the inspired oxygen fraction (FiO2) to 0.14. A highly significant improvement (p < 0.005) in arterial and venous O2 content and lower arteriovenous O2 difference (p < 0.05), cardiac output, and hemoglobin (p < 0.005) were found in the test group during hypoxia. The results show that it is possible to meet a physiologically significant portion of the body's O2 demands via the intestine during respiratory hypoxia and suggests that similar devices may be of significant potential value as a supplemental oxygenation device in cases of respiratory distress.
authors: Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
authors: B D
authors: BD
authors: Gross
authors: E
authors: E
authors: Sacristán
authors: R A
authors: RA
authors: Peura
authors: A
authors: A
authors: Shahnarian
authors: D
authors: D
authors: Devereaux
authors: H L
authors: HL
authors: Wang
authors: R
authors: R
authors: Fiddian-Green
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000502:physiology; D004195:Disease Models, Animal; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D000860:Hypoxia / Q000097:blood / Q000628:therapy; D007082:Ileum / Q000098:blood supply / Q000601:surgery; D008297:Male; D017538:Mesenteric Artery, Superior / Q000502:physiology; D008642:Mesenteric Veins / Q000502:physiology; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood; D010107:Oxygenators, Membrane; D019736:Prostheses and Implants; D011897:Random Allocation; D012039:Regional Blood Flow / Q000502:physiology; D012131:Respiratory Insufficiency / Q000097:blood / Q000628:therapy; D013552:Swine
chemical_list: D006454:Hemoglobins; D002245:Carbon Dioxide; D010100:Oxygen