[Comparative study of hemodynamic effects of antidepressants (tetrindole and desipramine) during immobilization stress in hypertensive rats].
Tetrindole (a tetracyclic antidepressant, reversible MAO inhibitor of the A type) and desipramine (a tricyclic antidepressant, nonselective inhibitor of the reverse catecholamine trapping) produce opposite hemodynamic effects in stroke-prone hypertensive rats (SHR-SP): tetrindole reduced, whereas desipramine increased, the heart rate and arterial pressure. Under the acute immobilization stress conditions in SHR-SP, tetrindole inhibited development of the post-stressor tachycardia, while desipramine did not change the heart rate and increased the arterial pressure.
Korshunov
V A
VA
Pushchino Department, Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Murashev
A N
AN
Ivashev
M N
MN
Dugin
S F
SF
Medvedev
O S
OS
D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000009:adverse effects / Q000494:pharmacology*; D003891:Desipramine / Q000009:adverse effects / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007103:Immobilization; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*; D013329:Structure-Activity Relationship
D000928:Antidepressive Agents; D002227:Carbazoles; C082644:tetrindole; D003891:Desipramine