Stimulation of the mesencephalic locomotor region inhibits the discharge of neurons in the superficial laminae of the dorsal horn of cats.
In decerebrate cats, we found that stimulation of the mesencephalic locomotor region (MLR) attenuated the responses of neurons in the superficial laminae of the dorsal horn to thin fiber muscle afferent input. The attenuation appeared to be more effective for group III afferent input than for group IV. These findings may shed light on the interaction between central command, (i.e. the MLR) and the muscle reflex, mechanisms which both contribute to the cardiovascular responses to exercise.
Degtyarenko
A M
AM
Division of Cardiovascular Medicine, Departments of Internal Medicine and Human Physiology, University of California, Davis, CA 95616, USA. amdegt@ucdavis.edu
Kaufman
M P
MP
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D004525:Efferent Pathways / Q000166:cytology / Q000502:physiology*; D004558:Electric Stimulation; D009043:Motor Activity / Q000502:physiology*; D009470:Muscle Spindles / Q000166:cytology / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology; D020671:Posterior Horn Cells / Q000166:cytology / Q000502:physiology*; D012018:Reflex / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*; D013681:Tegmentum Mesencephali / Q000166:cytology / Q000502:physiology*; D013979:Tibial Nerve / Q000166:cytology / Q000502:physiology