Molecular crosstalk in host-parasite relationships: schistosome- and leech-host interactions.
The host-parasite relationship is based on subtle interplay between parasite survival strategies and host defense mechanisms. In this context, parasites often use the same or similar immune signaling molecules and/or molecular mimicry to escape host immunosurveillance. Both processes represent an adaptive strategy to ensure host immunocompatibility. This bidirectional communication between parasites and their hosts includes the renin-angiotensin, opioid and opiate systems. Here, Michel Salzet, André Capron and George Stefano review recent work on the interaction of common signaling mechanisms in schistosomes, leeches and their host.
Salzet
M
M
Laboratoire d'Endocrinologie des Annélides, UPRES-A CNRS 8017, SN3, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq, Cédex, France. michel.salzet@univ-lille1.fr
Capron
A
A
Stefano
G B
GB
D000809:Angiotensins / Q000502:physiology; D000818:Animals; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D014644:Genetic Variation / Q000235:genetics*; D006790:Host-Parasite Interactions; D006801:Humans; D007865:Leeches / Q000235:genetics / Q000276:immunology*; D009020:Morphine / Q000494:pharmacology; D011333:Pro-Opiomelanocortin / Q000502:physiology; D012083:Renin / Q000502:physiology; D012550:Schistosoma mansoni / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction
D000809:Angiotensins; D011333:Pro-Opiomelanocortin; D009020:Morphine; D012083:Renin