[The study on hereditary polymorphism of thiopurine S-methyltransferasein Chinese Han population of Shanghai area].
OBJECTIVE
To gain an insight into the hereditary polymorphism of thiopurine methyltransferase(TPMT) activity in Chinese Han population of Shanghai.


METHODS
The present authors measured the erythrocyte TPMT activity in 320 healthy Chinese volunteers and 51 children with acute lymphoblastic leukemia(ALL) by means of radiochemical assay.


RESULTS
The TPMT activity levels ranged from 4. 32 to 32.33 U/ml pRBCs, with a mean value of (16.64+/-4.50) U/ml pRBCs, male (16.78+/-4.96) U/ml pRBCs, female (16.52+/-4.44) U/ml pRBCs. Eight point one percent of the sample had low activity. The TPMT activity levels for subjects who were <12 years, 13-18 years, 19-45 years and >45 years old were (16.52+/-4.31) U/ml pRBCs, (16. 71+/-4.24) U/ml pRBCs, (16.28+/-5.21) U/ml pRBCs and (17.11+/-3.98) U/ml pRBCs, respectively; the TPMT activity levels for healthy volunteers and patients with ALL were (16.65+/-4.72) U/ml pRBCs and (16.52+/-4.47) U/ml pRBCs, respectively.


CONCLUSIONS
There were no differences of TPMT activity in gender, age, and between healthy volunteers and patients with ALL.
Ye
Q
Q
Department of Pediatric Hematology/ Oncology, Xinhua Hospital/Shanghai Childrenns Medical Center, Shanghai Second Medical University, Shanghai, 200092 P.R.China. yeqidong@yahoo.com
Gu
L
L
Zhao
J
J
Liang
A
A
Ye
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*
D008780:Methyltransferases; C022745:thiopurine methyltransferase