Sex hormone-binding globulin during puberty in normal and hyperandrogenic girls.
Human sex hormone-binding globulin (SHBG) regulates the cellular bioavailability of SHBG-bound steroid hormones. Subtle decreases in plasma SHBG levels during puberty have a perceptible effect on the androgen-estrogen balance. This SHBG decrease is more pronounced in girls with premature pubarche who are at risk to develop functional ovarian hyperandrogenism as well as insulin resistance syndrome. Insulin is a potent inhibitor of SHBG production in the liver, and there is now evidence that SHBG is a marker of hyperinsulinemia and insulin resistance that can be associated in both obese and non-obese patients with polycystic ovary syndrome. Therefore, low SHBG could be a useful tool for identifying presymptomatic individuals with diabetes mellitus type 2 including those with androgen disorders.
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Hospices Civils de Lyon, Fédération d'Endocrinologie, H pital de l'Antiquaille, France. michel.pugeat@chu-lyon.fr
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D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood*; D011627:Puberty / Q000097:blood*; D011629:Puberty, Precocious / Q000097:blood; D012016:Reference Values; D012738:Sex Hormone-Binding Globulin / Q000032:analysis* / Q000235:genetics
D012738:Sex Hormone-Binding Globulin