Enzymatic hydrolysis of O-acyl esters of oxprenolol.
The stability of each O-acyl derivative was investigated in a solution of hydrochloric acid, artificial gastric juice, phosphate buffer at pH 7.4 and in artificial intestinal juice. A study of the relationship between the structure and enzymatic hydrolysis of the homologous series of oxprenolol esters was made.
Nogowska
M
M
Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
D004952:Esters / Q000737:chemistry; D005750:Gastric Juice / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D010096:Oxprenolol / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D004952:Esters; D010096:Oxprenolol