title: HLA-C and guttate psoriasis.
abstract: BACKGROUND
  Psoriasis is a heterogeneous disease in its clinical expression. Both genetic and environmental factors are thought to contribute to the pathogenesis of the inflammatory and hyperproliferative components of the typical skin lesions. Predisposing genetic influences include associations with human leucocyte antigens (HLA) of which that with HLA-Cw6 is the strongest. Guttate psoriasis is a specific clinical manifestation of psoriasis frequently associated with group A beta-haemolytic streptococcal throat infection.
  
  
  OBJECTIVE
  We set out to determine whether further clinical subdivision of psoriasis is associated with tighter correlation with HLA-C alleles.
  
  
  METHODS
  We determined the HLA-C locus genotype of 29 caucasian patients with guttate psoriasis presenting consecutively with guttate psoriasis associated with a history of a sore throat and/or an antistreptolysin O titre > 200 IU mL-1. Polymerase chain reaction typing using sequence-specific primers was used to detect all known HLA-C alleles. These data were compared with a control population of 604 random caucasian cadaver donors.
  
  
  RESULTS
  All patients (100%) with guttate psoriasis carried the Cw*0602 allele compared with 20% of the control population (odds ratio = infinity; 95% confidence limits 25.00-infinity; Pcorrected < 0.0000002).
  
  
  CONCLUSIONS
  This result is consistent with HLA-Cw*0602 playing a part directly in the pathogenesis of guttate psoriasis.
authors: Tissue Typing Laboratory, Churchill Hospital, Oxford, U.K.
authors: E
authors: E
authors: Mallon
authors: M
authors: M
authors: Bunce
authors: H
authors: H
authors: Savoie
authors: A
authors: A
authors: Rowe
authors: R
authors: R
authors: Newson
authors: F
authors: F
authors: Gotch
authors: C B
authors: CB
authors: Bunker
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010612:Pharyngitis / Q000382:microbiology; D016133:Polymerase Chain Reaction / Q000379:methods; D011565:Psoriasis / Q000145:classification / Q000175:diagnosis* / Q000235:genetics; D013290:Streptococcal Infections / Q000150:complications
chemical_list: D015236:HLA-C Antigens