title: Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome.
abstract: BACKGROUND
  Patients with irritable bowel syndrome (IBS) frequently complain of excessive gas but their fasting volume of intestinal gas is apparently normal. We hypothesised that the pathophysiological mechanism involved may be impairment of intestinal gas transit.
  
  
  OBJECTIVE
  To investigate intestinal gas transit and tolerance in IBS patients compared with healthy subjects.
  
  
  METHODS
  A gas mixture (N(2), O(2), and CO(2) in venous proportions) was infused into the jejunum of 20 patients with IBS and 20 healthy controls at 12 ml/min for four hours. Gas evacuation, initially flatus from the anus (two hours) and then intrarectally (two hours), was continuously recorded. Symptom perception (0-6 scale) and abdominal distension were measured at 10 minute intervals.
  
  
  RESULTS
  After two hours of external gas (flatus) collection, 18 of 20 IBS patients had developed gas retention (>400 ml), increased gastrointestinal symptoms (score >3), or abdominal distension (>3 mm girth increment) compared with only four of 20 control subjects. During intrarectal gas collection, 13 of 17 patients still exhibited abnormal responses.
  
  
  CONCLUSIONS
  A large proportion of patients with IBS can be shown to have impaired transit and tolerance of intestinal gas loads. This anomaly may represent a possible mechanism of IBS symptoms, specifically pain and bloating.
authors: Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Barcelona, Spain.
authors: J
authors: J
authors: Serra
authors: F
authors: F
authors: Azpiroz
authors: J R
authors: JR
authors: Malagelada
mesh_terms: D000005:Abdomen; D000328:Adult; D001003:Anal Canal / Q000503:physiopathology; D002245:Carbon Dioxide; D016022:Case-Control Studies; D003109:Colonic Diseases, Functional / Q000503:physiopathology*; D005260:Female; D005414:Flatulence / Q000503:physiopathology; D005740:Gases; D005772:Gastrointestinal Transit; D006801:Humans; D007422:Intestines / Q000503:physiopathology*; D007583:Jejunum / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009584:Nitrogen; D010100:Oxygen; D012007:Rectum / Q000503:physiopathology; D015203:Reproducibility of Results; D018709:Statistics, Nonparametric
chemical_list: D005740:Gases; D002245:Carbon Dioxide; D009584:Nitrogen; D010100:Oxygen