Abnormal peripheral auditory asymmetry in schizophrenia.
OBJECTIVE
Auditory processing difficulties have been reported in schizophrenia. This study explores peripheral auditory function in patients with schizophrenia in whom certain early disturbances of auditory message filtering have been found and may be associated with certain abnormalities which are particularly localised in the left temporal lobe.


METHODS
Otoacoustic emissions, including click evoked and spontaneous emissions and measurements of functioning of the medial olivocochlear efferent system were obtained from 12 chronic schizophrenic patients and compared with normative data recorded from 12 normal controls.


RESULTS
Otoacoustic emission amplitudes and medial olivocochlear functioning were similar between the normal controls and schizophrenic patients; the schizophrenic patients did, however, differ from the normal controls in otoacoustic emission intensity and in medial olivocochlear asymmetry. A tendency to a higher number of spontaneous peaks, and a significantly higher click evoked otoacoustic emission response amplitude were found in the right ear compared with the left ear of schizophrenic patients. For the medial olivocochlear system, whereas normal controls showed greater attenuation in the right than in the left ear, schizophrenic patients lacked such an asymmetry.


CONCLUSIONS
In the absence of any attention task, the findings show disturbed peripheral lateralisation in schizophrenia of mechanisms involved in auditory information filtering. Such a lack of right ear advantage in medial olivocochlear functioning may thus be a peripheral reflection of central lateralisation anomalies.
Veuillet
E
E
UMR CNRS 5020, Neurosciences et Systèmes Sensoriels, Hôpital Edouard Herriot, Pavillon U, 3 Place d'Arsonval, 69437 Lyon Cedex 03, France. evelyne.veuillet@chu-lyon.fr
Georgieff
N
N
Philibert
B
B
Dalery
J
J
Marie-Cardine
M
M
Collet
L
L
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001308:Auditory Perceptual Disorders / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology