Involvement of platelet activating factor in the endotoxin-induced effects on gastrointestinal electrical activity and some haematological parameters in the conscious miniature pig.
In conscious miniature pigs the influence of intravenous dose of lipopolysaccharide (LPS), 10 microg/kg over 10 min, with and without pretreatment with a platelet activating factor (PAF) antagonist, SAH 63-675 10 mg/kg, on gastrointestinal electrical activity, arterial pressure and clinical and haematological parameters was studied. Dose of LPS provoked mild clinical signs and hypotension, which were prevented by PAF antagonism. The LPS induced leukocytosis and increase in mature neutrophils, however, were PAF independent. Pretreatment with the PAF antagonist attenuated the LPS-provoked inhibition of electrical activity in the antrum, jejunum, ileum and caecum. These results suggest a beneficial effect of PAF antagonism in porcine endotoxaemia.
Wechsung
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Laboratory of Veterinary Physiology, University of Antwerp, Slachthuislaan 68, B-2060 Antwerp, Belgium.
Houvenaghel
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D000818:Animals; D004064:Digestive System / Q000187:drug effects; D004068:Digestive System Physiological Phenomena; D004305:Dose-Response Relationship, Drug; D004576:Electromyography / Q000662:veterinary; D019446:Endotoxemia / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D005663:Furans / Q000494:pharmacology; D007262:Infusions, Intravenous / Q000662:veterinary; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000633:toxicity*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D013552:Swine; D013553:Swine Diseases / Q000503:physiopathology*; D013556:Swine, Miniature / Q000502:physiology*
D005663:Furans; D008070:Lipopolysaccharides; D010972:Platelet Activating Factor; C403053:SAH 63-675