[Granulocyte colony-stimulating factor producing undifferentiated carcinoma of urinary bladder: a case report].
A case of bladder cancer producing granulocyte colony-stimulating factor (G-CSF) is reported. A 94-year-old woman with a progressive, grade 3 undifferentiated carcinoma, showed marked leukocytosis (maximum 29,780/mm3) with an elevated G-CSF (420 pg/ml). Immunohistochemical examination with monoclonal antibody specific for G-CSF revealed positive staining. Further examination for epidermal growth factor receptor (EGF-R) and p53 were both positive and Ki67 index were 40.7%. These data suggested that this tumor had extremely aggressive growing nature, as the biological character is this.
Kajio
K
K
Department of Urology, National Kyusyu Cancer Center.
Hasegawa
Y
Y
Ihara
K
K
Harada
S
S
Kawauchi
S
S
Fukuda
T
T
Naito
S
S
D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology
D016179:Granulocyte Colony-Stimulating Factor