title: Value of bone scan imaging in predicting pain relief from percutaneous vertebroplasty in osteoporotic vertebral fractures.
abstract: OBJECTIVE
  Patient selection for percutaneous vertebroplasty is often complicated by the presence of multiple fractures or non-localizing pain. Our purpose was to determine whether increased activity revealed by bone scan imaging is predictive of a positive clinical response to percutaneous vertebroplasty.
  
  
  METHODS
  A retrospective chart review conducted at our institution yielded 28 vertebroplasty treatment sessions that had been performed after obtaining bone scan imaging for painful, osteoporotic compression fractures in 27 patients. Thirty-five compression fractures were treated during these 28 treatment sessions. In all cases, increased activity was revealed by bone scan imaging before treatment with vertebroplasty. Positive outcome was defined as subjective decrease in pain severity and/or increased level of patient mobility.
  
  
  RESULTS
  Subjective pain relief was noted in 26 (93%) of 28 treatment sessions. In 14 (100%) of 14 cases with quantifiable pain levels, pain improved at least 3 points on a 10-point scale (range of improvement, 3-10 points; mean improvement, 7.4 points). Among the remaining 14 treatment sessions in which patients were unable or unwilling to quantify pain severity, the pain relief was described as complete or excellent pain relief in 11 (78%) of 14 cases. In 14 (100%) of 14 cases for which semiquantitative assessment of mobility was available, mobility improved at least one level (5-point graded scale; range of improvement, 1-4 points; mean improvement, 1.7 points).
  
  
  CONCLUSIONS
  Increased activity revealed by bone scan imaging is highly predictive of positive clinical response to percutaneous vertebroplasty.
authors: Department of Radiology, University of Virginia Health Services, Charlottesville 22908, USA.
authors: A S
authors: AS
authors: Maynard
authors: M E
authors: ME
authors: Jensen
authors: P A
authors: PA
authors: Schweickert
authors: W F
authors: WF
authors: Marx
authors: J G
authors: JG
authors: Short
authors: D F
authors: DF
authors: Kallmes
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications; D010147:Pain Measurement; D018579:Patient Selection; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D016103:Spinal Fractures / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D013669:Technetium Tc 99m Medronate; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate