Blood irradiation with accelerator produced electron beams.
Blood and blood products are irradiated with gamma rays to reduce the risk of graft versus host disease (GVHD). A simple technique using electron beams produced by a medical linear accelerator has been studied to evaluate irradiation of blood and blood products. Variations in applied doses for a single field 20 MeV electron beam are measured in a phantom study. Doses have been verified with ionization chambers and commercial diode detectors. Results show that the blood product volume can be given a relatively homogeneous dose to within 6% using 20 MeV electrons without the need to rotate the blood bags or the beam entry point. The irradiation process takes approximately 6.5 minutes for 30 Gy applied dose to complete as opposed to 12 minutes for a dual field x-ray field irradiation at our centre. Electron beams can be used to satisfactorily irradiate blood and blood products in a minimal amount of time.
Butson
M J
MJ
City University of Hong Kong, Department of Physics and Materials Science, Kowloon Tong. mbutson@usa.net
Cheung
T
T
Yu
P K
PK
Stokes
M J
MJ
D001769:Blood / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D006801:Humans; D010315:Particle Accelerators; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*