[Anti-aggregant activity of the blood vessel wall and its regulation by GABAergic agents in hypokinesia].
Restricted motor activity on the background of platelet hyperaggregation in the whole blood and plasma leads to inhibition of the antiaggregant activity of the blood vessel wall, thus creating prerequisites for the development of thromboembolic disturbances. Under these conditions, GABA and piracetam produce a pronounced protective action with respect to the platelet-vessel wall interactions.
Edigarova
L V
LV
Department of Pharmacology, Erevan State Medical University, Armenia.
Akopian
V P
VP
D000818:Animals; D001808:Blood Vessels / Q000473:pathology*; D018476:Hypokinesia / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009043:Motor Activity; D010889:Piracetam / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D005680:gamma-Aminobutyric Acid; D010889:Piracetam