Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae.
Streptococcus pneumoniae clinical isolate BM4455 was resistant to 16-membered macrolides and to streptogramins. This unusual resistance phenotype was due to an A(2062)C (Escherichia coli numbering) mutation in domain V of the four copies of 23S rRNA.
Depardieu
F
F
Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France.
Courvalin
P
P
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D009154:Mutation / Q000235:genetics; D009841:Oligonucleotides / Q000494:pharmacology; D010641:Phenotype; D012338:RNA, Ribosomal, 23S / Q000235:genetics*; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*; D014769:Virginiamycin / Q000378:metabolism / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D009841:Oligonucleotides; D012338:RNA, Ribosomal, 23S; D014769:Virginiamycin