Emergence of new influenza A viruses which carry an escape mutation of the HLA-B27-restricted CTL epitope of NP in Japan.
Influenza A viruses (H3N2) isolated in 1998 in Nagasaki, Japan, carried a mutation (384R --> G) in one of the anchor amino acids of the HLA-B27-restricted cytotoxic T lymphocyte (CTL) epitope of NP (383-391). Phylogenetic analysis revealed that these viruses have been isolated only in Japan to date and belong to the unique lineages.
Kashiwagi
T
T
Department of Virology, Kunrume University School of Medicine, Fukuoka, Japan.
Hamada
N
N
Iwahashi
J
J
Hara
K
K
Ueda
T
T
Noguchi
H
H
Toyoda
T
T
D000818:Animals; D002648:Child; D002675:Child, Preschool; D018984:Epitopes, T-Lymphocyte / Q000235:genetics* / Q000276:immunology; D015796:HLA-B27 Antigen / Q000378:metabolism*; D006801:Humans; D009980:Influenza A virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000276:immunology* / Q000821:virology; D008969:Molecular Sequence Data; D009154:Mutation; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D010802:Phylogeny; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014758:Viral Core Proteins / Q000235:genetics* / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D015796:HLA-B27 Antigen; D019590:Nucleocapsid Proteins; D009698:Nucleoproteins; D014758:Viral Core Proteins