Determination of telomerase activity in squamous cell carcinoma of the penis.
Telomerase activity was studied in 51 penile carcinomas, and detected in all samples from 3 patients with verrucous carcinoma, in 85.4% (41/48) of invasive carcinomas, in 81.8% (9/11) of adjacent non-cancerous skin and in 80% (8/10) of adjacent non-cancerous corpus cavernosum. All skin and corpus cavernosum samples from patients with prostatic carcinoma were found to be telomerase negative. Our results indicate a correlation between frequency of telomerase activity and grade of penile carcinoma. The finding of telomerase activity in skin and corpus cavernosum samples adjacent to tumor suggests that unidentified local factors may modulate telomerase activity in normal tissues.
Alves
G
G
Divisão de Genética, Instituto Nacional de Câncer, 20230-130 Rio de Janeiro, Brazil. gbrown@inca.org.br
Fiedler
W
W
Guenther
E
E
Nascimento
P
P
Campos
M M
MM
Ornellas
A A
AA
D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010412:Penile Neoplasms / Q000201:enzymology* / Q000503:physiopathology; D019098:Telomerase / Q000032:analysis*
D014408:Biomarkers, Tumor; D019098:Telomerase