Coumarins and antiplatelet constituents from the root bark of Zanthoxylum schinifolium.
Further study on the chloroform-soluble portion of the root bark of Zanthoxylum schinifolium led to the isolation of eight new coumarins: methylschinilenol (1), hydroxyepoxycollinin I (2), 8-methoxyanisocoumarin H (3), hydroxyschininallylol (4), hydroxyepoxycollinin II (5), schinitrienin (6), schininallylone (7), and isoschinilenol (8), along with twenty-six known compounds including fourteen coumarins, and nine alkaloids. The structural elucidation was determined by spectroscopic data. Among the isolates, terpenyl-coumarins and furoquinolines were the active constituents with antiplatelet aggregation in vitro and collinin (10) showed significant anti-HBC DNA replication activity.
Tsai
I L
IL
School of Pharmacy, Kaohsiung Medical University, Taiwan, R.O.C.
Lin
W Y
WY
Teng
C M
CM
Ishikawa
T
T
Doong
S L
SL
Huang
M W
MW
Chen
Y C
YC
Chen
I S
IS
D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D018517:Plant Roots / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D019685:Rosales / Q000737:chemistry*; D013057:Spectrum Analysis
D003374:Coumarins; D010975:Platelet Aggregation Inhibitors