[Psychotic syndrome after withdrawal of cyproheptadine: remission with olanzapine].
Cyproheptadine is a drug with direct antimuscarinic, antihistaminic (H1) and antiseronergic (5HT2) effects. In spite of its use as an orexigenic agent in normal or anorectic subjects, little is known about its effect in affective, anxiety or psychotic disorders. We present the case of a 14-year patient beginning with a psychotic syndrome after the sudden withdrawal cyproheptadine, achieving a total control of the symptoms with olanzapine at low dose, besides a good family, school and social adaptation.
De Lucas Taracena
M T
MT
Unidad de Salud Mental Infantojuvenil, Cuenca.
Alcaina Prosper
T
T
Huélamo Ortega
M J
MJ
D000293:Adolescent; D001569:Benzodiazepines; D003533:Cyproheptadine / Q000009:adverse effects*; D005260:Female; D006634:Histamine H1 Antagonists / Q000009:adverse effects*; D006801:Humans; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D012702:Serotonin Antagonists / Q000009:adverse effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000523:psychology; D013577:Syndrome
D001569:Benzodiazepines; D003533:Cyproheptadine; D006634:Histamine H1 Antagonists; D000077152:Olanzapine; D010890:Pirenzepine; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors