Plasma glucose-insulin relationship in chicken lines selected for high or low fasting glycaemia.
1. Selected Fat or Lean chickens differ in their plasma glucose insulin relationship: in the fed or fasted state, Fat chickens have a lower glycaemia associated with normal or higher insulinaemia, depending upon the difference in glycaemia. 2. Conversely, chickens selected for low fasting glycaemia (LG) are fattier than their counterparts selected for high fasting glycaemia (HG), although the divergence in fat content is lower than in the Fat-Lean model. 3. The plasma glucose insulin relationship has been investigated in males of the HG and LG lines in the F4 and F5 generations. 4. A difference in glycaemia is suggested during embryonic development and was present at hatching and later on in the fasted or the fed state; insulinaemia did not differ. 5. During refeeding after an overnight fast, glycaemia differed between lines (except at intermediate times); cumulative food intake and insulinaemia were similar. 6. During a glucose tolerance test, glucose disposal rate and insulinaemia were rather similar. 7. Exogenous insulin exerted a very similar hypoglycaemic effect in both lines. 8. Other variables (body temperature, plasma concentrations of potassium and alpha NH2-non protein nitrogen) did not differ between HG and LG chickens. 9. In conclusion, HG and LG chickens do not exhibit any differences in glucose disposal rate, insulinaemia (in various nutritional conditions) or sensitivity to exogenous insulin, which contrasts with Fat or Lean chickens and may explain why HG and LG chickens have diverged to a lesser extent in fat content.
Simon
J
J
Station de Recherches Avicoles, INRA, Nouzilly, France. simon@tours.inra.fr
Guillaumin
S
S
Chevalier
B
B
Derouet
M
M
Guy
G
G
Marche
G
G
Ricard
F H
FH
Leclercq
B
B
D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D001831:Body Temperature; D002642:Chick Embryo; D002645:Chickens / Q000235:genetics* / Q000502:physiology; D005215:Fasting; D005951:Glucose Tolerance Test / Q000662:veterinary; D007328:Insulin / Q000097:blood / Q000235:genetics* / Q000502:physiology; D008297:Male; D009584:Nitrogen / Q000097:blood; D010783:Photometry; D011188:Potassium / Q000097:blood; D012641:Selection, Genetic; D012964:Sodium / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D012964:Sodium; D009584:Nitrogen; D011188:Potassium