title: A study of the relationship between the structure of homologous series of oxprenolol at various pH values.
abstract: Stability of series of O-acyl esters of oxprenolol prepared as potential pro-drugs, is investigated over the pH range 0.4-10 at 37 degrees C. Maximum stability of all esters occurred at pH 3-4. The most stable derivative was found to be pivaloyl ester. The relationship between Charton Steric parameters (v) and the catalytic rate constant of hydrolysis is investigated.
authors: Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
authors: M
authors: M
authors: Nogowska
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D010096:Oxprenolol / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: D000319:Adrenergic beta-Antagonists; D010096:Oxprenolol