Spurious systolic hypertension in youth.
Six young men diagnosed with systolic hypertension had normal carotid pressure wave contours, normal synthesized aortic pressure wave contours and normal diastolic and mean pressures in upper limb arteries. Elevated brachial systolic pressure was caused by a high narrow systolic peak of the pressure wave. This was attributed to amplification of the pressure wave between the ascending aorta and upper limb (radial and brachial) arteries that is associated with attainment of full body length and very distensible arteries. These young men were not truly hypertensive. Exaggeration of the upper limb systolic peak represented an extreme of the normal pressure wave pattern in youth, where amplification is greater than in childhood or in older subjects. This phenomenon accounts for the rapid increase in systolic pressure between the ages of 5 and 20 years, and the relative plateau in systolic pressure between the ages of 20 and 45 years that is seen in population studies.
O'Rourke
M F
MF
Medical Professorial Unit, University of NSW, St Vincent's Clinic, Darlinghurst, Sydney, Australia.
Vlachopoulos
C
C
Graham
R M
RM
D000293:Adolescent; D000328:Adult; D001795:Blood Pressure Determination / Q000379:methods*; D001916:Brachial Artery; D002339:Carotid Arteries; D003971:Diastole; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D017534:Radial Artery; D012016:Reference Values; D015203:Reproducibility of Results; D013599:Systole