Independence of sleep EEG responses to GABAergic hypnotics: biological implications.
GABAergic hypnotics are known to depress non-rapid eye movement delta and rapid eye movements and to stimulate non-rapid eye movement sigma (spindles) and beta EEG. This study addressed the question of whether the magnitudes of these effects are significantly correlated. Data were from a study in 16 normal subjects whose sleep was recorded for five nights under placebo and for three nights each under zolpidem (10 mg), triazolam (0.25 mg) and temazepam (30 mg). EEG was analyzed with both period-amplitude and power spectral (FFT) analysis. The magnitudes of the EEG and eye movement density responses were not significantly correlated for any of the three drugs. It is therefore unlikely that sleep responses to GABAergic drugs can be explained by the common cellular action (increased chloride conductance) of these drugs. We suggest that the sleep EEG responses are manifestations of complex (but consistent) interactions of excitation and inhibition in large brain systems although certain aspects of these responses (e.g. the different time courses of delta vs sigma and eye movement responses) may reflect molecular adaptations. A separate observation in this study was the strong traitlike characteristics of the sleep variables studied. These variables were highly correlated across nights of baseline sleep; in addition, individual differences in baseline sleep were significantly retained on the third night of temazepam administration.
Palagini
L
L
Psychiatry Clinic, University of Pisa, Pisa, Italy.
Campbell
I G
IG
Tan
X
X
Guazzelli
M
M
Feinberg
I
I
D000328:Adult; D004569:Electroencephalography / Q000187:drug effects*; D001330:Electronic Data Processing; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D015203:Reproducibility of Results; D012895:Sleep, REM / Q000187:drug effects*; D013693:Temazepam / Q000494:pharmacology*; D014229:Triazolam / Q000494:pharmacology*; D000077334:Zolpidem
D018755:GABA Agonists; D006993:Hypnotics and Sedatives; D011725:Pyridines; D014229:Triazolam; D000077334:Zolpidem; D013693:Temazepam