Successful non-surgical treatment of disseminated polymicrobial fungal infection in a patient with pancytopenia and graft-versus-host disease.
Invasive fungal infections after bone marrow transplantation have an extremely poor prognosis. Surgical excision in combination with antifungal therapy is considered necessary for treatment, especially for central nervous system (CNS) infection. We describe successful medical management with lipid complex amphotericin B (ABLC) and itraconazole, without surgical excision, of disseminated fungal infection involving the lungs and CNS in a patient with pancytopenia and graft-versus-host disease.
Roy
V
V
Hematology-Oncology Section, Blood and Bone Marrow Transplantation Program, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
Ali
L I
LI
Carter
T H
TH
Selby
G B
GB
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy*; D016026:Bone Marrow Transplantation; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D006086:Graft vs Host Disease / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use*; D008224:Lymphoma, Follicular / Q000150:complications / Q000628:therapy; D008297:Male; D009091:Mucormycosis / Q000188:drug therapy*; D009894:Opportunistic Infections / Q000188:drug therapy; D010198:Pancytopenia / Q000150:complications*; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D010715:Phosphatidylglycerols / Q000627:therapeutic use*
D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B