Inhibin B response to EFORT is associated with the outcome of oocyte retrieval in the subsequent in vitro fertilization cycle.
OBJECTIVE
To examine whether the magnitude of the rise in inhibin B levels after gonadotropin challenge is associated with subsequent response to ovarian stimulation during IVF.


METHODS
Inhibin B serum levels after EFORT (exogenous follicle-stimulating hormone ovarian reserve test).


METHODS
Academic clinical practice.


METHODS
Serum samples from women who had undergone ovarian reserve screening with FSH in preparation for IVF. Thirteen of these women had a poor response in IVF (canceled cycle for low estradiol and/or no oocytes retrieved), and 19 had a good response (> or =10 oocytes retrieved).


METHODS
EFORT test.


METHODS
Baseline (day 3) serum E(2) (bE(2)), FSH (bFSH), and inhibin B (bInhB) levels and inhibin B and E(2) levels 24 hours after EFORT (DeltaInhB and DeltaE(2)).


RESULTS
The mean bInhB and DeltaInhB levels were significantly higher in good vs. poor responders. The odds ratio of having a good response for women with a DeltaInhB of 202 pg/mL was 51.8 times (95% CI = 6.1-1,244) the corresponding odds for women with a DeltaInhB of 49 pg/mL. As expected, DeltaE(2) was also significantly higher in good vs. poor responders; however, combination of DeltaE(2) plus DeltaInhB did not improve the odds for predicting IVF response.


CONCLUSIONS
Our data suggest that DeltaInhB after EFORT may provide a method for predicting ovarian response to hyperstimulation in a subsequent IVF cycle.
Dzik
A
A
Department of Obstetrics and Gynecology, Womens Hospital of São Paulo and Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Lambert-Messerlian
G
G
Izzo
V M
VM
Soares
J B
JB
Pinotti
J A
JA
Seifer
D B
DB
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D009865:Oocytes; D010050:Ovarian Function Tests; D010455:Peptides / Q000097:blood*; D029584:Prostatic Secretory Proteins; D012189:Retrospective Studies; D013048:Specimen Handling; D013997:Time Factors; D016896:Treatment Outcome
D010455:Peptides; D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; D004958:Estradiol; D005640:Follicle Stimulating Hormone