title: Highly selective aziridination of imines using trimethylsilyldiazomethane and applications of C-silylaziridines in synthesis
abstract: Trimethylsilyldiazomethane has been found to add directly to N-sulfonyl (Ts and SES) imines to afford aziridines in good yields and high cis stereoselectivities. The silyl group can be substituted by treatment with a fluoride source and electrophiles again with high selectivity. Complete regioselectivity is observed in ring opening of these aziridines with nucleophiles.
authors: Department of Chemistry, University of Sheffield, Sheffield S3 7HF, U.K.
authors: VK
authors: Aggarwal
authors: M
authors: Ferrara