[Immunogenic activity of temperature sensitive mutation of herpes simplex virus type-1 in mono- and polyvalent conditions with different attenuated strains of virus. II. Analysis of humoral immunologic response induced by mutants of temperature sensitive herpes simplex type-1 virus in polyvalent systems].
The ability of mutant ts HSV-1 on 45 passage to induction of IgG antibody response in the presence of other attenuated viral strain, like measles, mumps, rubella was evaluated, and the effect of mutant ts HSV-1 on humoral immunity induced by attenuated measles and mumps strains was also tested. The obtained results clearly indicated that even immunization with other RNA virus strains had no effect on IgG antibody response to mutant ts HSV-1. Significant differences were observed in IgG antibody responses to mumps and measles between groups of guinea pigs immunized with these viruses alone or together with other viruses. This was especially observed in the case of mumps virus. It clearly shows that change of virus concentration rates in polyvalent schema of immunization is needed.
Biesiadecka
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Zakład Wirusologii Państwowego Zakładu Higieny w Warszawie.
D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D019433:Chickenpox Vaccine; D006168:Guinea Pigs; D018259:Herpesvirus 1, Human / Q000235:genetics* / Q000254:growth & development / Q000276:immunology*; D014645:Herpesvirus 3, Human / Q000254:growth & development / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis*; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D009154:Mutation; D013696:Temperature; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D014775:Virus Activation
D019433:Chickenpox Vaccine; D007074:Immunoglobulin G; D022542:Measles-Mumps-Rubella Vaccine; D017778:Vaccines, Combined; D014765:Viral Vaccines; C050102:measles, mumps, rubella, varicella vaccine