title: The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene.
abstract: Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C-terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.
authors: Laboratoires de Cytogénétique et d'Hématologie, Hématologie clinique, Hôpital du Bocage, Dijon, France.
authors: F
authors: F
authors: Mugneret
authors: M
authors: M
authors: Chaffanet
authors: M
authors: M
authors: Maynadié
authors: G
authors: G
authors: Guasch
authors: B
authors: B
authors: Favre
authors: O
authors: O
authors: Casasnovas
authors: D
authors: D
authors: Birnbaum
authors: M J
authors: MJ
authors: Pébusque
mesh_terms: D000368:Aged; D002888:Chromosomes, Human, Pair 19; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D009196:Myeloproliferative Disorders / Q000235:genetics*; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D051496:Receptor, Fibroblast Growth Factor, Type 1; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D017468:Receptors, Fibroblast Growth Factor; C496348:FGFR1 protein, human; D020794:Receptor Protein-Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1