Model suspensions of indomethacin "solvent deposited" on cellulose polymers.
The properties of indomethacin "sorbates" with hydrophilic cellulose carriers (optimal drug/carrier ratio 1:1 (w/w)) were studied in the solid state and in the form of 0.5% aqueous dispersions. The polymers used were: methyl-(MC), hydroxyethyl-(HEC), hydroxyethylmethyl-(HEMC), hydroxypropyl-(HPC), sodium carboxymethyl-(CMC-Na) and microcrystalline celluloses. It was found that the "solvent deposited" indomethacin, unlike the pure drug, exists predominantly as the alpha-polymorph, and possesses improved wettability and higher aqueous solubility (the increase was approximately 2-3 times). The indomethacin/cellulose sorbates can be easily transformed into 0.5% aqueous dispersions. The "primary" dispersions were used as a basis for the formulation of new oral suspensions with improved rheological properties and physical stability. The new models behave as non-Newtonian fluids with pseudoplastic flow and good sediment redispersibility after shaking. The indomethacin/carboxymethylcellulose sodium 1:1 (w/w) sorbate suspension is the most suitable for future practical application.
Bogdanova
S
S
Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002482:Cellulose; D004337:Drug Carriers; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000737:chemistry*; D011108:Polymers; D012997:Solvents; D017550:Spectroscopy, Fourier Transform Infrared; D013535:Suspensions; D014783:Viscosity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D011108:Polymers; D012997:Solvents; D013535:Suspensions; D002482:Cellulose; D007213:Indomethacin