MAO-B inhibition by a single dose of l-deprenyl or lazabemide does not prevent neuronal damage following focal cerebral ischaemia in rats.
The present study investigated the effect of postischaemic infusion of an irreversible monoamine oxidase B (MAO-B) inhibitor, l-deprenyl, an equipotent dose of a reversible MAO-B inhibitor, lazabemide, or 0.9% NaCl on infarct volumes following focal cerebral ischaemia in rats. The drug doses (0.3 mg/kg) were selected to induce selective MAO-B inhibition (45-55%), but not MAO-A inhibition. The infarct volumes in the cortex or in the striatum did not differ between the experimental groups 72 hr after transient occlusion of the middle cerebral artery, which suggests that during ischaemia/reperfusion, suppressed oxidative stress by partial MAO-B inhibition or MAO-B independent mechanisms such as induction of trophic factors, does not protect against ischaemia/reperfusion damage.
Jolkkonen
J
J
Department of Neuroscience and Neurology, University of Kuopio, Finland. jukka.jolkkonen@uku.fi
Kauppinen
R
R
Nyman
L
L
Haapalinna
A
A
Sivenius
J
J
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D002545:Brain Ischemia / Q000201:enzymology* / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D010848:Picolinic Acids / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000627:therapeutic use*
D008996:Monoamine Oxidase Inhibitors; D010848:Picolinic Acids; D012642:Selegiline; C059303:lazabemide; D008995:Monoamine Oxidase