Malignant theca cell tumor of rat.
A large-sized ovarian tumor of theca cell origin was found in a female rat. The mass was located in the right ovary position. Histologically, the tumor was covered by thin fibrous capsule and consisted of a solid area and an abundant necrotic area. Tumor cells were arranged in a storiform or whorled pattern. Connective tissue elements occasionally presented as bundles of dense collagen fibers. Fusiform to elongated cells had oval- to spindle-shaped nuclei with indistinct nucleoli. Large round nuclei and mitotic figures were scattered throughout the tumor cells. These cells were stained positively with S-100 but negatively with vimentin and a-smooth muscle actin. Tumor cells with abundant cytoplasm sometimes contained multiple small-sized lipid vacuoles.
Ozaki
K
K
Research Institute of Drug Safety, Setsunan University, Osaka, Japan. ozaki@pharm.setsunan.ac.jp
Narama
I
I
D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D013798:Thecoma / Q000737:chemistry / Q000473:pathology / Q000662:veterinary*
D009418:S100 Proteins