title: Design, synthesis, and evaluation of a pyrrolinone-based matrix metalloprotease inhibitor.
abstract: [reaction: see text] A pyrrolinone-based hydroxamate matrix metalloprotease inhibitor, (-)-1, has been designed and synthesized. Enzymatic assay revealed that (-)-1 inhibited three of the ten matrix metalloprotease enzymes examined and as such represents a new, potentially important lead structure.
authors: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu
authors: A B
authors: AB
authors: Smith
authors: T
authors: T
authors: Nittoli
authors: P A
authors: PA
authors: Sprengeler
authors: J J
authors: JJ
authors: Duan
authors: R Q
authors: RQ
authors: Liu
authors: R F
authors: RF
authors: Hirschmann
mesh_terms: D000447:Aldehydes; D015195:Drug Design; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D007527:Isoenzymes; D011480:Protease Inhibitors; D011758:Pyrroles; D008666:Metalloendopeptidases