Increased DOI-induced head shakings in adult rats neonatally treated with MK-801.
We examined the effects of neonatal treatment with MK-801 on 1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head shaking as well as [(3)H]ketanserin binding in adult rats. Neonatal rats were injected with MK-801 (0.25 mg/kg, s.c., twice daily) or with saline from postnatal days (PND) 7-18. At PND 60, a statistically significant increase in the frequency of head shaking induced by DOI (1.0 mg/kg, s.c.) was observed in the rats neonatally treated with MK-801, compared to saline-treated rats, without any change in the specific [(3)H]ketanserin binding in the frontal cortex. These results suggest that repeated NMDA receptor blockades during the critical period of brain development produce a long lasting hyper-responsiveness in the 5-HT(2A) receptor-mediated behavior, interfering with the development of neural circuits related to the behavior.
Kurumaji
A
A
Department of Neuropsychiatry, Tokyo Medical and Dental University School of Medicine, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan. 0724.psyc@tmd.ac.jp
Aihara
O
O
Yamada
S
S
Toru
M
M
D000662:Amphetamines; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004357:Drug Synergism; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006257:Head / Q000503:physiopathology*; D007650:Ketanserin / Q000378:metabolism; D017397:Prefrontal Cortex / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012702:Serotonin Antagonists / Q000378:metabolism; D017366:Serotonin Receptor Agonists
D000662:Amphetamines; D018691:Excitatory Amino Acid Antagonists; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D016291:Dizocilpine Maleate; D007650:Ketanserin; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine