Morphological and pathological effects of cadmium ingestion on Pekin ducks exposed to saline.
This study examined the effects of simultaneous exposure to saline and cadmium (Cd) on organ mass and histology of a bird with salt glands, the Pekin duck, Anas platyrhynchos. Three mixed-sex groups, each containing 6 birds, ate duck pellets containing 0, 50, or 300 microg Cd/g, respectively, for 4 1/2 mo and drank 300 mM NaCl. Only females on the high-Cd diet lost body mass. Ingestion of Cd reduced heart mass in females. There was increased mass of Harderian and salt glands in both sexes. Mass of kidneys and liver increased only in males, and the gut mass (also length) increased more in males. Cadmium ingestion also induced (1) inflammation of renal interstitium and degenerative tubular changes, (2) marked degenerative changes in testes, (3) increased heart water content, (4) decreased cytoplasmic volume of liver cells, (5) reduced proportion of basophilic granular cells in chromaffin tissue of the adrenal glands, and (6) in the ileum, increased heterophilia in the lamina propria and, only in females, the apoptosis to mitosis ratio in crypt cells of the epithelium. The ducks' outward appearance gave no indication that ingesting large amounts of cadmium for 4 1/2 mo produced deleterious effects, but the physiological consequences were profound. Both sexes had greatly reduced gonadal mass and the males produced no sperm. The higher dietary level greatly hypertrophied the liver, kidneys, and gut only in males. The cadmium-induced changes in organs, particularly in the gonads, kidneys, and adrenal glands, should greatly impair the health and reproductive capacity of these ducks.
Hughes
M R
MR
Department of Zoology, University of British Columbia, Vancouver, Canada. Hughes@zoology.ubc.ca
Smits
J E
JE
Elliott
J E
JE
Bennett
D C
DC
D000818:Animals; D001715:Bird Diseases / Q000473:pathology*; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000493:pharmacokinetics; D002105:Cadmium Poisoning / Q000473:pathology / Q000662:veterinary*; D004064:Digestive System / Q000378:metabolism / Q000473:pathology; D004372:Ducks / Q000502:physiology*; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D012491:Salt Gland / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D012965:Sodium Chloride; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002104:Cadmium; D012965:Sodium Chloride; D008668:Metallothionein