Renal failure and cholestatic jaundice as unusual complications of childhood pustular psoriasis.
Generalized pustular psoriasis (GPP) is uncommon in children, and serious renal and liver complications arising from GPP are rarely reported. We describe a Chinese boy who had suffered from recurrent exacerbations of GPP from the age of 1 year. He developed IgA nephropathy at the age of 9 years. He also had recurrent episodes of oliguric renal failure, hepatomegaly and cholestasis associated with severe exacerbations of GPP. These complications progressed despite early antibiotics and supportive therapy, but responded promptly to intravenous methylprednisolone therapy. Ultimately, acitretin was given and he has successfully been in remission for a year.
Li
S P
SP
Departments of Paediatrics and Pathology, Tuen Mun Hospital, Tsing Chung Koon Road, Tuen Mun, Hong Kong SAR, China. psli@attglobal.net
Tang
W Y
WY
Lam
W Y
WY
Wong
S N
SN
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D002648:Child; D002779:Cholestasis / Q000209:etiology*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D011565:Psoriasis / Q000150:complications* / Q000188:drug therapy; D012008:Recurrence
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone