title: Body composition and dietary intake in relation to drug abuse in a cohort of HIV-positive persons.
abstract: We examined the relationships between drug abuse, weight, body composition, and dietary intake in persons infected with HIV in a cross-sectional analysis of baseline data from a longitudinal study of nutritional status and HIV. Body composition was measured by bioelectrical impedance analysis. Dietary data were collected by 3-day food records or 24-hour recalls. We analyzed data from 39 current intravenous drug users (IVDU), 103 past intravenous drug users (past-IVDU), 239 users of nonintravenous drugs (users-NIVD), and 61 nonusers (reference category). In the men, there were no differences in weight, body mass index (BMI), or body composition among the drug-use groups. In the women, there was a trend to lower weight and BMI across the drug use categories: IVDU women had lower average weight (-13.7 kg; p = .006), BMI (-5.6 units; p = .003) and less fat mass than non-users (-9.8 kg; p = .0001). In women, drug users had higher weight-adjusted energy intakes than nonusers, whereas in the men both drug using groups, NIVD and IVDU, had higher energy intakes than nonusers. These data suggest that intravenous drug-abuse is associated with lower weight and fat mass in women with HIV infection despite adequate self-reported energy intake.
authors: Department of Family Medicine and Community Health, Tufts University, Boston, Massachusetts, USA. janet.forrester@tufts.edu
authors: J E
authors: JE
authors: Forrester
authors: M N
authors: MN
authors: Woods
authors: T A
authors: TA
authors: Knox
authors: D
authors: D
authors: Spiegelman
authors: S C
authors: SC
authors: Skinner
authors: S L
authors: SL
authors: Gorbach
mesh_terms: D000328:Adult; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004032:Diet; D002149:Energy Intake; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000150:complications* / Q000503:physiopathology