Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function.
A-kinase anchoring proteins (AKAPs) are adapter proteins that are involved in directing cAMP-dependent protein kinase and some other signaling enzymes to certain intracellular locations. In this study, we investigate the domain architecture of an AKAP from Caenorhabditis elegans (AKAP(CE)). We show that AKAP(CE) shares two domains with the Smad anchor for receptor activation, a FYVE-finger and a transforming growth factor beta (TGFbeta) receptor binding domain, suggesting that AKAP(CE) may interact with a receptor belonging to the TGFbeta receptor family. This predicted novel AKAP function supports the recent view of AKAPs as adapter proteins that can be involved in various signaling pathways.
Herrgård
S
S
Department of Bioengineering, University of California, San Diego, CA 92093, USA.
Jambeck
P
P
Taylor
S S
SS
Subramaniam
S
S
D054758:A Kinase Anchor Proteins; D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D004331:Drosophila melanogaster; D015801:Helminth Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014982:Xenopus laevis; D016335:Zinc Fingers
D054758:A Kinase Anchor Proteins; C112944:A kinase anchor protein (kap-1), C elegans; D048868:Adaptor Proteins, Signal Transducing; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D015801:Helminth Proteins; D018125:Receptors, Transforming Growth Factor beta