title: Severe digital necrosis in an elderly patient with heterozygous factor V Leiden mutation.
abstract: We report an 81-year-old female with a heterozygous factor V Leiden mutation who developed purpura fulminans. Digital necrosis, a characteristic clinical feature of purpura fulminans was prominent. Purpura fulminans is more common in children and adult cases are rare. Of eight reported cases of purpura fulminans resulting from a heterozygous factor V Leiden mutation recorded in the literature, only two were in adults: 40 and 42 years of age, respectively. This is the first report of this condition arising in a patient in her eighties.
authors: Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, U.K. gkpatel@cardiff.ac.uk
authors: G K
authors: GK
authors: Patel
authors: E
authors: E
authors: Morris
authors: M R
authors: MR
authors: Rashid
authors: A V
authors: AV
authors: Anstey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005165:Factor V / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006579:Heterozygote; D006801:Humans; D011695:IgA Vasculitis / Q000235:genetics* / Q000473:pathology*; D009154:Mutation / Q000235:genetics*; D009336:Necrosis; D014034:Toes / Q000098:blood supply / Q000473:pathology*
chemical_list: C095381:factor V Leiden; D005165:Factor V