Hedgehog signaling and the axial patterning of Drosophila wings.
Growth and cell fate in the anterior-posterior (A/P) axis of the developing wing of Drosophila melanogaster are controlled by a stripe of cells bisecting the axis called the A/P organizer. Hedgehog (Hh) signaling from posterior to anterior cells induces the organizer. Several Hh-responsive genes expressed by cells of the organizer mediate its patterning activity. The Hh-signaling pathway controls the post-translational modification of the transcription factor Cubitus-interruptus (Ci) and the resulting local activation of Ci is required for the correct location of the A/P organizer.
Brook
W J
WJ
Department of Biochemistry & Molecular Biology, University of Calgary, AB, Canada. brook@ucalgary.ca
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000502:physiology; D029721:Drosophila Proteins; D004627:Embryonic Induction; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D007814:Larva; D009024:Morphogenesis / Q000235:genetics; D015398:Signal Transduction; D014157:Transcription Factors; D014921:Wings, Animal / Q000196:embryology / Q000254:growth & development / Q000648:ultrastructure*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D014157:Transcription Factors; C092937:ci protein, Drosophila; C077245:hh protein, Drosophila