title: Telomerase is a strong indicator for assessing the proneness to progression in neuroblastomas.
abstract: BACKGROUND
  As traditional parameters do not ensure completely accurate prognostic grouping in neuroblastoma (NB), new molecular markers are needed for assessing the individual patient's prognosis more precisely.
  Based on 133 NB, we show that telomerase activity (TA) is a powerful, independent prognostic marker for all stages and is capable of differentiating between good and poor outcome in putative 'favorable' clinical or biological subgroups of NB patients. Analysis of gene and protein expression of telomerase subunits suggests that the presence or absence of TA in NB is strongly correlated with expression levels of both the catalytic subunit hTERT and the internal RNA component (hTR).
authors: Gerhard-Domagk-Institute of Pathology, Westfälische Wilhelms-University, Münster, Germany. poremba@uni-muenster.de
authors: C
authors: C
authors: Poremba
authors: B
authors: B
authors: Hero
authors: B
authors: B
authors: Heine
authors: C
authors: C
authors: Scheel
authors: K L
authors: KL
authors: Schaefer
authors: H
authors: H
authors: Christiansen
authors: F
authors: F
authors: Berthold
authors: S
authors: S
authors: Kneif
authors: H
authors: H
authors: Stein
authors: H
authors: H
authors: Juergens
authors: W
authors: W
authors: Boecker
authors: B
authors: B
authors: Dockhorn-Dworniczak
mesh_terms: D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000201:enzymology* / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*
chemical_list: D019098:Telomerase