Effects of subtotal resection of the fundus on development of intestinal metaplasia induced by X-ray irradiation in Donryu rats.
Eight-week-old male Crj:Donryu rats underwent subtotal resection of the fundus and X-ray irradiation. Six months later the animals were autopsied and examined for intestinal metaplasia. The numbers of alkaline phosphatase-positive foci with the two treatments in combination were significantly increased, compared to the operation alone and non-treatment groups. Histologically assessed intestinal metaplasia was also increased in the combined treatment group. In conclusion, subtotal resection of the fundus combined with X-ray irradiation is an effective induction protocol for intestinal metaplasia.
Kinoshita
K
K
Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Watanabe
H
H
Ando
Y
Y
Katayama
M
M
Yamamoto
H
H
Hirano
N
N
Yoshikuni
S
S
Yamamoto
T
T
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005748:Gastric Fundus / Q000601:surgery*; D007413:Intestinal Mucosa / Q000201:enzymology / Q000473:pathology* / Q000528:radiation effects*; D008297:Male; D008679:Metaplasia / Q000209:etiology / Q000473:pathology; D011230:Precancerous Conditions / Q000209:etiology* / Q000473:pathology; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D000469:Alkaline Phosphatase