title: Intestinal permeability in Behçet's syndrome.
abstract: OBJECTIVE
  To measure the intestinal permeability in patients with Behçet's syndrome (BS) and to compare the results with those obtained from healthy and diseased controls.
  
  
  METHODS
  The study group comprised 34 patients with BS without known gastrointestinal disease. Ten patients with ankylosing spondylitis (AS), 6 with inflammatory bowel diseases (IBD), 17 with systemic lupus erythematosus (SLE), and 15 healthy subjects (HC) constituted the controls. All patients received 100 microCi (3.7 MBq) of chromium-51 EDTA ((51)Cr-EDTA) as a radioactive tracer after a 72 hour abstinence from all drugs. The percentage of the isotope excreted in a 24 hour urinary specimen was the measure of permeability.
  
  
  RESULTS
  The percentage (SD) rate of excretion of (51)Cr-EDTA was 4.6 (2.6) in BS, 6 (2.4) in AS, 5.2 (1. 9) in IBD, 5.56 (1.78) in SLE, and 2.3 (1) in healthy controls. (Analysis of variance: f=6.4, p=0.0002. BS v HC, AS v HC, SLE v HC significant.)
  
  
  CONCLUSIONS
  The intestinal permeability in BS was significantly more than that seen among the healthy controls. Similar results in all the diseased controls cast doubt on its specificity.
authors: Department of Rheumatology, Cerrahpaşa Medical Faculty, Istanbul, Turkey. freskoi@superonline.com
authors: I
authors: I
authors: Fresko
authors: V
authors: V
authors: Hamuryudan
authors: M
authors: M
authors: Demir
authors: N
authors: N
authors: Hizli
authors: H
authors: H
authors: Sayman
authors: M
authors: M
authors: Melikoğlu
authors: R
authors: R
authors: Tunç
authors: S
authors: S
authors: Yurdakul
authors: H
authors: H
authors: Yazici
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000503:physiopathology*; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology; D007408:Intestinal Absorption; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology; D008297:Male; D010539:Permeability; D013167:Spondylitis, Ankylosing / Q000503:physiopathology
chemical_list: D002860:Chromium Radioisotopes; D004492:Edetic Acid