title: Search for antiviral activity in higher plant extracts.
abstract: In the course of our search for plant natural products as antiviral agents, extracts of ten plants from the Iberian Peninsula were tested for antiviral activity against herpes simplex type I (HSV-1), vesicular stomatitis virus (VSV) and poliovirus type 1. Aqueous extracts of five of these medicinal plants, namely Nepeta nepetella (150-500 microg/mL), Nepeta coerulea (150-500 microg/mL), Nepeta tuberosa (150-500 microg/mL), Dittrichia viscosa (50-125 microg/mL) and Sanguisorba minor magnolii (50-125 microg/mL), showed a clear antiviral activity against two different DNA and RNA viruses, i.e. HSV-1 and VSV. Only the medicinal plant Dittrichia viscosa was active against an additional virus, poliovirus type 1.
authors: Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
authors: M J
authors: MJ
authors: Abad
authors: J A
authors: JA
authors: Guerra
authors: P
authors: P
authors: Bermejo
authors: A
authors: A
authors: Irurzun
authors: L
authors: L
authors: Carrasco
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003588:Cytopathogenic Effect, Viral; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D017955:Poliovirus / Q000187:drug effects / Q000254:growth & development; D012588:Scintillation Counting; D013030:Spain; D013462:Sulfur Radioisotopes; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts; D013462:Sulfur Radioisotopes