title: Retro-nociceptin methylester, a peptide with analgesic and memory-enhancing activity.
abstract: Retro-nociceptin methylester (retro-Noc-ME), which has an oppositely directed structure to that of nociceptin, showed weak affinity for nociceptin receptor and antagonized nociceptin-induced inhibition of contraction in a guinea pig ileum (GPI) assay. The peptide induced analgesia after intracerebroventricular (i.c.v.) administration at a dose of 100 nmol per mouse. Analgesia was not blocked by the opioid antagonist naloxone, which suggests that the analgesia is not mediated by opioid receptor. Furthermore, analgesia caused by retro-Noc-ME was not attenuated after repeated administration, that is, there was an absence of tolerance. The peptide improved learning ability after i.c.v. administration in a step-through experiment in mice.
authors: Research Institute for Food Science, Kyoto University, Uji, Japan.
authors: Y
authors: Y
authors: Jinsmaa
authors: M
authors: M
authors: Takahashi
authors: H
authors: H
authors: Fukunaga
authors: M
authors: M
authors: Yoshikawa
mesh_terms: D000595:Amino Acid Sequence; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D006168:Guinea Pigs; D007276:Injections, Intraventricular; D007858:Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects; D000094942:Nociceptin Receptor
chemical_list: D000700:Analgesics; D010455:Peptides; D011957:Receptors, Opioid; C417725:retro-nociceptin methylester; D000094942:Nociceptin Receptor