The regulation of protein function by multisite phosphorylation--a 25 year update.
The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. 'Multisite phosphorylation can enable several such effects to operate in the same protein. It can also determine the extent and duration of a response and is the key to signal integration.
Cohen
P
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MRC Protein Phosphorylation Unit, MSI/WTB Complex, University of Dundee, Dundee, UK DD1 5EH. pcohen@dundee.ac.uk
D002412:Cations / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D015533:Transcriptional Activation
D002412:Cations; D011506:Proteins; D011494:Protein Kinases