Pharmacogenetics: role in modifying drug dosage regimens.
With the advent of new molecular biology and scientific techniques, there is better understanding of genetic polymorphisms in oxidative drug metabolism systems today. These systems are important in pharmacogenetic studies which genotype polymorphic alleles encoding drug metabolising enzymes to enable the individual's drug metabolising phenotype to be found. Once found, the knowledge can be used to tailor drug dosage regimens to an individual to maximise therapeutic efficacy and minimise adverse drug reactions (ADRs). The knowledge could also be used to optimise drug development programmes so that all the subgroups within a target population are adequately represented in clinical trails.
Mah
J T
JT
Department of Pharmacology, Faculty of Medicine, National University of Singapore, Building MD2, 18 Medical Drive, Singapore 117597.
Wong
J Y
JY
Lee
E J
EJ
D001189:Aryl Hydrocarbon Hydroxylases; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004358:Drug Therapy; D005006:Ethnicity; D005838:Genotype; D006801:Humans; D006899:Mixed Function Oxygenases / Q000235:genetics; D017891:Pharmacoepidemiology; D010597:Pharmacogenetics; D010641:Phenotype; D011110:Polymorphism, Genetic
D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D019389:Cytochrome P-450 CYP2D6