Stress-free T-cell development: glucocorticoids are not obligatory.
A role for glucocorticoids in thymopoiesis has been suggested by studies using glucocorticoid receptor (GR) anti-sense transgenic mice, glucocorticoid synthesis inhibitors and GR antagonists. Unfortunately, no consensus has been reached on exactly how glucocorticoids influence T-cell development. The most recent approach, using GR knockout (GR(-/-)) mice, indicates that GR signaling is, in fact, dispensable in this entire process.
Godfrey
D I
DI
Monash University Medical School, Department of Pathology and Immunology, Commercial Road, VIC. 3181, Prahran, Australia. dale.godfrey@med.monash.edu.au
Purton
J F
JF
Boyd
R L
RL
Cole
T J
TJ
D000616:Aminoglutethimide / Q000494:pharmacology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D017637:Clonal Deletion / Q000187:drug effects; D016373:DNA, Antisense / Q000235:genetics; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D006410:Hematopoiesis / Q000187:drug effects; D006727:Hormone Antagonists / Q000494:pharmacology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008797:Metyrapone / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D015735:Mifepristone / Q000494:pharmacology; D008954:Models, Biological; D011965:Receptors, Glucocorticoid / Q000172:deficiency / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D013312:Stress, Physiological / Q000276:immunology* / Q000503:physiopathology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013950:Thymus Gland / Q000196:embryology / Q000276:immunology
D016373:DNA, Antisense; D005938:Glucocorticoids; D006727:Hormone Antagonists; D011965:Receptors, Glucocorticoid; D000616:Aminoglutethimide; D015735:Mifepristone; D008797:Metyrapone