Glycosidic flavonoids as rat-liver injury preventing compounds from green tea.
A glycosidic flavonoids-rich fraction from green tea leaves was purified to isolate five glycosidic flavonoids, guided by the detection of a preventive effect on D-galactosamine-induced liver injury in rats. These were identified as a flavone C-glycoside (1) and trisaccharide flavonols (2-5) based on the spectroscopic analyses. These compounds suppressed the D-galactosamine-induced increase of plasma alanine aminotransferase and asparatate aminotransferase activities in rats.
Wada
S
S
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan.
He
P
P
Hashimoto
I
I
Watanabe
N
N
Sugiyama
K
K
D000818:Animals; D002240:Carbohydrate Sequence; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005688:Galactosamine / Q000633:toxicity*; D006027:Glycosides / Q000737:chemistry*; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment
D005419:Flavonoids; D006027:Glycosides; D005688:Galactosamine