title: Comparison of titanium vascular closure staples with suture repair of the thoracic aorta in swine.
abstract: OBJECTIVE
  Devices that reduce technical difficulty and anastigmatic time when repairing large vessels such as the thoracic aorta would be beneficial. The aim of this study was to determine if titanium vascular closure staples (3 mm) could be safely and quickly applied in the repair of large vessels such as the thoracic aorta.
  
  
  METHODS
  Through a left thoracotomy in 10 female swine (110 to 130 lb), an interposition graft (14 to 16 mm textile) was placed into the aorta distal to the left subclavian artery. Animals were randomized at the time of repair to either running sutures (n = 5; 6-0 polypropylene) or vascular closure staples (n = 5; 3 mm). The anastomosis was evaluated after 2 months with aortograms, and the aorta was harvested to evaluate healing.
  
  
  RESULTS
  The clamp times (mean +/- SD) were 30.8 +/- 8.2 min for suture repair and 24.8 +/- 5.1 min for vascular closure staple repair (p = 0.2). Anastomosis times were 20. 0 +/- 6.2 min for the suture group and 16.4 +/- 6.4 min for the vascular closure staple group (p = 0.4). Arch aortograms at 2 months revealed no significant difference in luminal narrowing between the two groups. Gross and microscopic examination revealed no thrombosis, well-healed wounds with a continuous intimal layer, and no differences in intimal thickness or inflammation between the two groups.
  
  
  CONCLUSIONS
  Vascular closure staples were equivalent to sutures in terms of durability, graft patency, and wound healing at 2 months. Vascular closure staples may offer the trauma surgeon a quick and easy alternative when repairing large vessels such as the thoracic aorta.
authors: Department of Surgery, National Naval Medical Center, Bethesda, MD 20814, USA.
authors: S
authors: S
authors: Deb
authors: B
authors: B
authors: Martin
authors: L
authors: L
authors: Sun
authors: D
authors: D
authors: Burris
authors: D
authors: D
authors: Wherry
authors: E
authors: E
authors: Pikoulis
authors: P
authors: P
authors: Rhee
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery*; D005260:Female; D013528:Surgical Staplers; D017792:Surgical Stapling; D013537:Sutures; D013552:Swine; D014025:Titanium; D014945:Wound Healing
chemical_list: D014025:Titanium