title: Pathologic rupture of the spleen during induction with ATRA in a patient with acute promyelocytic leukemia.
abstract: Pathological rupture of the spleen is a rare but well recognized complication in hematological malignancies. Early clinical recognition of this life-threatening complication is necessary for rapid intervention. Here, we report on the case of a 26-year-old woman with acute promyelocytic leukemia who presented rupture of the spleen on day +2 of treatment with ATRA plus idarrubicin. In patients with acute leukemia, the presence of a painful abdomen and a sudden drop in hemoglobin levels, should alert of a possible splenic rupture, even without additional symptoms. This would facilitate an early treatment intervention with no modification to the chemotherapy schedule.
authors: Servicio de Hematología, Hospital Universitario de Salamanca, Spain. robert-69@medicosmix.com
authors: R
authors: R
authors: Hernández
authors: M C
authors: MC
authors: del Cañizo
authors: C
authors: C
authors: López
authors: M I
authors: MI
authors: González
authors: M L
authors: ML
authors: Vázquez
authors: M D
authors: MD
authors: Caballero
authors: J F
authors: JF
authors: San Miguel
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000008:administration & dosage; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications* / Q000188:drug therapy; D012422:Rupture, Spontaneous; D013161:Splenic Rupture / Q000175:diagnosis / Q000209:etiology*; D014212:Tretinoin / Q000008:administration & dosage
chemical_list: D014212:Tretinoin; D015255:Idarubicin