Inhibition of interleukin-1-induced uveitis and corneal fibroblast proliferation by interleukin-1 blockers.
Interleukin-1 (IL-1) is known to trigger induction of inducible nitric oxide synthase (iNOS) to persistently mass produce nitric oxide (NO) to induce various diseases such as cancer, inflammation, Alzheimer's disease and eye diseases, including uveitis, retinopathy, age-related macular degeneration, glaucoma and myopia. Therefore, IL-1 blockers could become an important class of drugs to fight numerous diseases. Among the many compounds studied so far, 1-methyl hydrazino analogs are among the most promising agents to be developed. A minor structural change of 1-methyl hydrazino group into 1-methyl thiosemicarbazido group enhanced their anti-inflammatory activity but reduced their antiproliferation activity on corneal fibroblast cell growth.
Chiou
G C
GC
Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology, Texas A & M University System Health Science Center, College of Medicine, College Station 77843-1114, USA. gchiou@tamu.edu
Xuan
B
B
Liu
Q
Q
Yamasaki
T
T
Okawara
T
T
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003315:Cornea / Q000166:cytology / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D007375:Interleukin-1 / Q000037:antagonists & inhibitors*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014605:Uveitis / Q000517:prevention & control*
D007375:Interleukin-1; D012333:RNA, Messenger; D004247:DNA