Regional variation in oral mucosal drug permeability.
The purpose of this article is to review regional variation in oral mucosal drug permeability. The structure and composition of the mucosa at different sites in the oral cavity, factors affecting mucosal permeability, selection of appropriate experimental systems for studying mucosal permeability, and formulation factors including penetration enhancement relevant to the design of systems for oral mucosal delivery are reviewed.
Kurosaki
Y
Y
Graduate School of Natural Science and Technology, Okayama University, Japan.
Kimura
T
T
D000042:Absorption; D000818:Animals; D001692:Biological Transport; D002610:Cheek; D016503:Drug Delivery Systems; D006801:Humans; D009061:Mouth Mucosa / Q000378:metabolism*; D010455:Peptides / Q000493:pharmacokinetics; D010477:Perfusion; D010539:Permeability
D010455:Peptides