The possible involvement of 3-methoxy-2(5H)-furanone in the etiology of Narthecium asiaticum maxim. associated nephrotoxicity in cattle.
Two samples of Narthecium asiaticum Maxim leaves collected in Japan were found to contain 103 microg(-1) and 160 microg g(-1) dry matter of 3-methoxy-2(5H)-furanone respectively. 3-Methoxy-2(5h)-furanone was suggested to be the toxic principle of N. asiaticum causing nephrotoxicity in cattle in Japan. Two other furanones, which are thought to be non-toxic, were also isolated from the two samples. These were 4-methoxy-2(5H)-furanone and 5-hydroxy-4-methoxy-2(5H)-furanone.
Flåøyen
A
A
National Veterinary Institute, Oslo, Norway. arne.flaoyen@vetinst.no
Torgersen
T L
TL
Langseth
W
W
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced* / Q000473:pathology; D004196:Disease Outbreaks / Q000662:veterinary; D005663:Furans / Q000032:analysis / Q000506:poisoning*; D007564:Japan; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D010936:Plant Extracts / Q000032:analysis; D010939:Plant Poisoning / Q000473:pathology / Q000662:veterinary*; D010947:Plants, Toxic / Q000737:chemistry*
C403722:3-methoxy-2(5H)-furanone; D005663:Furans; D010936:Plant Extracts