title: Improvement of sleep architecture in PD with subthalamic nucleus stimulation.
abstract: High-frequency stimulation of the subthalamic nucleus (STN) was used to investigate the relationship of sleep disorders with motor handicap in PD. In 10 insomniac patients with PD, stimulation reduced nighttime akinesia by 60% and completely suppressed axial and early morning dystonia, but did not alleviate periodic leg movements (n = 3) or REM sleep behavior disorders (n = 5). Total sleep time increased by 47%; wakefulness after sleep onset decreased by 51 minutes. Insomnia in patients with PD may predominantly result from nighttime motor disability.
authors: Centre d'Investigation Clinique, Fédération de Neurologie and INSERM U289, Paris, France. isabelle.arnulf@psl.ap-hop-paris.fr
authors: I
authors: I
authors: Arnulf
authors: B P
authors: BP
authors: Bejjani
authors: L
authors: L
authors: Garma
authors: A M
authors: AM
authors: Bonnet
authors: J L
authors: JL
authors: Houeto
authors: P
authors: P
authors: Damier
authors: J P
authors: JP
authors: Derenne
authors: Y
authors: Y
authors: Agid
mesh_terms: D000328:Adult; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000503:physiopathology*