title: 2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1.
abstract: N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.
authors: Ontogen Corporation, Carlsbad, CA 92009, USA. sep.sarshar@agouron.com
authors: S
authors: S
authors: Sarshar
authors: C
authors: C
authors: Zhang
authors: E J
authors: EJ
authors: Moran
authors: S
authors: S
authors: Krane
authors: J C
authors: JC
authors: Rodarte
authors: K D
authors: KD
authors: Benbatoul
authors: R
authors: R
authors: Dixon
authors: A M
authors: AM
authors: Mjalli
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects* / Q000502:physiology; D018432:Drug Resistance, Multiple; D007093:Imidazoles / Q000494:pharmacology*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007093:Imidazoles