Antigen presentation: peptides and proteins scramble for the exit.
The fate of peptides that fail to bind to major histocompatibility complex class I molecules in the endoplasmic reticulum (ER)has remained unclear. A recent study has revealed that these peptides exit the ER via the Sec61 channel and compete for this pathway with misfolded proteins.
Lehner
P J
PJ
Division of Immunology, Wellcome Trust Centre for Molecular Mechanisms In Disease, CIMR, Addenbrooke's Hospital, Hills Road, CB2 2XY, Cambridge, UK. pjl30@cam.ac.uk
Hewitt
E W
EW
Römisch
K
K
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D000069816:SEC Translocation Channels
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D010455:Peptides; D000069816:SEC Translocation Channels; C073119:TAP1 protein, human; C071692:TAP2 protein, human