Determination of the enantiomerization barrier of oxazepam by dynamic micellar electrokinetic chromatography--comparison of experiment and simulation with ChromWin 99.
The pH-dependent and temperature-controlled enantiomerization of oxazepam has been studied by dynamic micellar electrokinetic chromatography in an aqueous buffer system with sodium cholate as the chiral surfactant. Experimental interconversion profiles featuring plateau formation were simulated by the new program ChromWin 99. Peak form analysis yielded rate constants and kinetic activation parameters of the enantiomerization of oxazepam between 5 degrees C and 25 degrees C.
Schoetz
G
G
Universität Tübingen, Institut für Organische Chemie, Auf der Morgenstelle 18 72076 Tübingen, Germany.
Trapp
O
O
Schurig
V
V
D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D010076:Oxazepam / Q000737:chemistry*; D013237:Stereoisomerism
D010076:Oxazepam