title: Structure and function of the ion channel ICln.
abstract: Normal function of organs and cells is tightly linked to the cytoarchitecture. Control of the cell volume is therefore vital for the organism. A widely established strategy of cells to counteract swelling is the activation of chloride and potassium channels, which leads to a net efflux of salt followed by water - a process termed regulatory volume decrease. Since there is evidence for swelling-dependent chloride channels (IClswell) being activated also during pathological processes, the identification of the molecular entity underlying IClswell is of utmost importance. Several proteins are discussed as the channel forming IClswell, i.e. phospholemman, p-glycoprotein, CLC-3 and ICln. In this review we would like to focus on the properties of ICln, a protein cloned from a Madin Darby canine kidney (MDCK) cell library whose expression in Xenopus laevis oocytes resulted in a nucleotide sensitive outwardly rectifying chloride current closely resembling the biophysical properties of IClswell.
authors: Department of Physiology, University of Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria.
authors: J
authors: J
authors: Fürst
authors: M
authors: M
authors: Jakab
authors: M
authors: M
authors: König
authors: M
authors: M
authors: Ritter
authors: M
authors: M
authors: Gschwentner
authors: J
authors: J
authors: Rudzki
authors: J
authors: J
authors: Danzl
authors: M
authors: M
authors: Mayer
authors: C M
authors: CM
authors: Burtscher
authors: J
authors: J
authors: Schirmer
authors: B
authors: B
authors: Maier
authors: M
authors: M
authors: Nairz
authors: S
authors: S
authors: Chwatal
authors: M
authors: M
authors: Paulmichl
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018118:Chloride Channels / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
chemical_list: D018118:Chloride Channels