Basal 17beta-estradiol did not correlate with ovarian response and in vitro fertilization treatment outcome.
OBJECTIVE
To verify the correlation of basal 17beta-E(2) with ovarian response to stimulation and outcome of in vitro fertilization (IVF).


METHODS
Retrospective observational study.


METHODS
The Assisted Conception Unit, University College London Hospitals.


METHODS
Three hundred five women undergoing IVF and IVF with intracytoplasmic sperm injection.


METHODS
Basal follicle-stimulating hormone (FSH) and 17beta-E(2) were assessed. The cutoff level for day 2 E(2) established was 250 pmol/L. Each patient was noted for below (group A) or above (group B) the cutoff point according to her basal E(2) level.


METHODS
Basal E(2), age, duration of infertility, cycle day 2 FSH, number of ampules of gonadotropin used, number of days of stimulation, number of retrieved oocytes, fertilization rate, number of embryos transferred, number of cycles with embryo freezing, cancellation rate, clinical pregnancy rate, and implantation rate were compared between the two groups.


RESULTS
No differences were found between group A and group B in the number of oocytes retrieved (8.8 +/- 4.2 vs. 9.3 +/- 4.8), embryos transferred (2.5 +/- 0.8 vs. 2.7 +/- 0.7), cancellation (9.1% vs. 6.9%), pregnancy (24.8% vs. 30%), and implantation rate (12.3% vs. 15.6%). Correlation coefficient and coefficient of determination showed no significant correlation between basal E(2) and the number of oocytes retrieved, age, and basal FSH.


CONCLUSIONS
In our study population, basal E(2) was not a sensitive predictor of ovarian response to stimulation and did not correlate with IVF outcome.
Phophong
P
P
Assisted Conception Unit, University College London Hospital, London, United Kingdom.
Ranieri
D M
DM
Khadum
I
I
Meo
F
F
Serhal
P
P
D000328:Adult; D004958:Estradiol / Q000097:blood*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000628:therapy; D008596:Menotropins / Q000627:therapeutic use*; D010053:Ovary / Q000187:drug effects* / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D011994:Recombinant Proteins / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
D005300:Fertility Agents, Female; D011994:Recombinant Proteins; D004958:Estradiol; D008596:Menotropins; D005640:Follicle Stimulating Hormone