Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis.
In this study we investigated the distribution of apolipoprotein E (APO E) genotypes in sporadic multiple sclerosis (MS) cases and in normal controls. Later onset of chronic progressive MS was observed in patients carrying the epsilon2 allele, whereas APO E alleles were found at similar frequency in MS and in the control population. These findings indicate that clinical heterogeneity, but probably not susceptibility to the disease, is associated to APO E genotypes.
Ballerini
C
C
Department of Neurological and Psychiatrical Sciences, University of Florence, Viale Pieraccini 6, 50134, Florence, Italy. neuroimm@cesit1.unifi.it
Campani
D
D
Rombolà
G
G
Gran
B
B
Nacmias
B
B
Amato
M P
MP
Siracusa
G
G
Bartolozzi
L
L
Sorbi
S
S
Massacesi
L
L
D000328:Adult; D017668:Age of Onset; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D012307:Risk Factors
D001057:Apolipoproteins E