title: Combination propofol-ketamine anaesthesia in sick neonates.
abstract: Two critically ill, opioid-tolerant neonates were anaesthetized using pancuronium and a mixture of propofol (PROP) and ketamine (KET). Three mg of KET were added per ml (10 mg) of PROP in a single syringe and infused at a rate of 100-150 microg x kg(-1) x min(-1) of the PROP component (30-45 microg x kg(-1) x min(-1) KET). Total doses of 12-15 and 3.6-4.5 mg x kg(-1) of PROP and KET, respectively, were administered. Both patients remained haemodynamically stable throughout their surgical procedures. PROP-KET is a rational and effective combination for intravenous anaesthesia in critically ill neonates who are likely to be opioid-tolerant when an anaesthesia vaporizer is not readily available.
authors: Loyola University Medical Center, Department of Anesthesiology, Maywood, IL 60153, USA.
authors: S
authors: S
authors: Golden
mesh_terms: D000771:Anesthesia, Intravenous; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D000778:Anesthetics, Dissociative / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D016638:Critical Illness; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007649:Ketamine / Q000008:administration & dosage*; D008297:Male; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D019162:Anesthetics, Combined; D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D007649:Ketamine; D015742:Propofol