Responses to innocuous, but not noxious, somatosensory stimulation by neurons in the ferret superior colliculus.
The intermediate and deep layers of the superior colliculus (SC) are known for their role in initiating orienting behaviors. To direct these orienting functions, the SC of some animals (e.g., primates, carnivores) is dominated by inputs from the distance senses (vision, audition). In contrast, the rodent SC relies more heavily on non-visual inputs, such as touch and nociception, possibly as an adaptive response to the proximity of dangers encountered during their somatosensory-dominant search behaviors. The ferret (a carnivore) seems to employ strategies of both groups: above ground they use visual/auditory cues, but during subterranean hunting ferrets must rely on non-visual signals to direct orienting. Therefore, the present experiments sought to determine whether the sensory inputs to the ferret SC reveal adaptations common to functioning in both environments. The results showed that the ferret SC is dominated (63%; 181/286) by visual/auditory inputs (like the cat), rather than by somatosensory inputs (as found in rodents). Furthermore, tactile responses were driven primarily from hair-receptors (like cats), not from the vibrissae (as in rodents). Additionally, while a majority of collicular neurons in rodents respond to brief noxious stimulation, no such neurons were encountered in the ferret SC. A small proportion (4%; 13/286) of the ferret SC neurons were responsive to long-duration (>5 s) noxious stimulation, but further tests could not establish these responses as nociceptive. Collectively, these data indicate that the ferret SC is best adapted for the animal's visuallacoustically guided activities and most closely resembles the SC of its phylogenetic relative, the cat.
Meredith
M A
MA
Department of Anatomy, Virginia Commonwealth University School of Medicine, Richmond 23298-0709, USA. mameredi@hsc.vcu.eu
Clemo
H R
HR
Dehner
L R
LR
Dehneri
L R
LR
D000161:Acoustic Stimulation; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D005289:Ferrets; D005552:Forelimb / Q000294:innervation / Q000502:physiology; D006614:Hindlimb / Q000294:innervation / Q000502:physiology; D008297:Male; D009474:Neurons / Q000145:classification / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology; D010775:Photic Stimulation; D010812:Physical Stimulation; D012684:Sensory Thresholds / Q000502:physiology; D013045:Species Specificity; D013477:Superior Colliculi / Q000166:cytology / Q000502:physiology*; D014110:Touch / Q000502:physiology; D014738:Vibrissae / Q000294:innervation / Q000502:physiology