[Genetic polymorphism in hOGG1 and susceptibility to esophageal cancer in Chinese].
OBJECTIVE
To examine the association between Ser326Cys polymorphism in hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in damaged DNA, and investigate the risk of squamous cell carcinoma of the esophagus in Chinese.


METHODS
Ser326Cys polymorphism in hOGG1 gene was determined by PCR-SSCP approach among 201 normal controls and 196 patients with squamous cell carcinoma of the esophagus. The association between this genetic polymorphism and the risk of the cancer was examined by a multivariate analysis.


RESULTS
The Cys/Cys genotype of hOGG1 was found in 21.4% of patients with the cancer and in 13.4% of controls (P<0.05). Homozygosity for the Cys/Cys genotype significantly increased the risk of developing esophageal cancer, with the odds ratio adjusted for age, sex and smoking being 1.9(95% CI 1.3-2.6). Smoking also significantly increased esophageal cancer risk in this case-control study (adjusted OR 2.6; 95% CI 1.7- 3.9). No interaction between smoking and Cys/Cys genotype was observed for the risk of esophageal cancer.


CONCLUSIONS
Polymorphism of hOGG1 Ser326Cys may play a role in esophageal carcinogenesis.
Xing
D
D
Cancer Institute, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100021 P.R.China.
Tan
W
W
Song
N
N
Lin
D
D
D000328:Adult; D000368:Aged; D004260:DNA Repair; D043382:DNA-Formamidopyrimidine Glycosylase; D004938:Esophageal Neoplasms / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009699:N-Glycosyl Hydrolases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational
D009699:N-Glycosyl Hydrolases; D043382:DNA-Formamidopyrimidine Glycosylase