New-onset tic disorder following acute hemorrhage of an arteriovenous malformation.
The etiology of tic disorder includes idiopathic, postencephalitic, head injury, carbon monoxide poisoning, stroke, and developmental syndromes. We report a case of new-onset complex motor and vocal tics that began after hemorrhage of an arteriovenous malformation located in the left frontal lobe. We have found no reported cases of new-onset tics related to arteriovenous malformations or hemorrhage into the frontal lobes. The patient is a 16-year-old right-hand-dominant boy who presented with generalized tonic-clonic seizures. Evaluation, including magnetic resonance imaging, revealed a left frontal arteriovenous malformation, confirmed by angiogram. Following resection, there was an intraparenchymal hemorrhage of the left frontal lobe with intraventricular hemorrhage, noted most prominently in the left lateral and IIIrd ventricles, and a subdural hematoma caudal to the craniotomy. The postoperative course was complicated by hemiparesis and global aphasia. During recovery, the patient developed what was thought to be a complex partial seizure evidenced by head turning to the right with vocalization and left upper extremity clonic jerks. These were brief and occurred multiple times per day. A trial of carbamazepine was given with no improvement. It was noted that the spells occurred more frequently under stress, as when the patient was frustrated with communication. The diagnosis was changed to complex motor tics and the therapy changed to clonidine. The tics subsequently improved by 80%, although they were still present. We believe the development of complex motor tics due to frontal hemorrhage represents a unique etiology and could complicate postsurgical recovery in similar cases.
Yochelson
M R
MR
Department of Child and Adolescent Neurology, Walter Reed Army Medical Center, Washington, DC 20307, USA. duke91@dnamail.com
David
R G
RG
D000208:Acute Disease; D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000209:etiology; D003000:Clonidine / Q000627:therapeutic use*; D003399:Craniotomy / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004830:Epilepsy, Tonic-Clonic / Q000175:diagnosis / Q000209:etiology; D005625:Frontal Lobe / Q000473:pathology* / Q000601:surgery; D006408:Hematoma, Subdural / Q000209:etiology; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D013981:Tic Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D016896:Treatment Outcome
D000316:Adrenergic alpha-Agonists; D003000:Clonidine