title: Loss of sinus compliance, cause of degenerative aortic valve disease, and early failure of biological valves.
abstract: Loss of compliance of aortic sinuses due to aging or graft replacement causes significant aortic valve leaflet dysfunction. This event leads to stress overload and induces degenerative changes in the patient's (natural or bioprosthetic) valve and unfavorably influences leaflet longevity.
authors: F
authors: F
authors: Robicsek
authors: M J
authors: MJ
authors: Thubrikar
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D001021:Aortic Valve / Q000502:physiology* / Q000503:physiopathology*; D003198:Computer Simulation; D006349:Heart Valve Diseases / Q000209:etiology*; D006439:Hemodynamics; D006801:Humans; D008953:Models, Anatomic; D012850:Sinus of Valsalva / Q000502:physiology*; D014741:Video Recording