Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein.
Durley
R C
RC
Pharmacia Discovery Research, 700 Chesterfield Parkway North, St. Louis, Missouri 63198, USA. richard.c.durley@monsanto.com
Grapperhaus
M L
ML
Massa
M A
MA
Mischke
D A
DA
Parnas
B L
BL
Fobian
Y M
YM
Rath
N P
NP
Honda
D D
DD
Zeng
M
M
Connolly
D T
DT
Heuvelman
D M
DM
Witherbee
B J
BJ
Glenn
K C
KC
Krul
E S
ES
Smith
M E
ME
Sikorski
J A
JA
D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000097:blood / Q000737:chemistry*; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters / Q000097:blood*; D018360:Crystallography, X-Ray; D006023:Glycoproteins; D006801:Humans; D066298:In Vitro Techniques; D011412:Propanolamines / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D002788:Cholesterol Esters; D006023:Glycoproteins; D011412:Propanolamines; C433230:SC 795