In vivo neuroprotection of injured CNS neurons by a single injection of a DNA plasmid encoding the Bcl-2 gene.
Saavedra
R A
RA
Department of Neurobiology and Anatomy, MCP Hahnemann University, Philadelphia, PA 19129, USA. saavedra@nih.gov
Murray
M
M
de Lacalle
S
S
Tessler
A
A
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D019771:Axotomy / Q000009:adverse effects; D019254:Genes, bcl-2 / Q000235:genetics*; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D000922:Immunotoxins / Q000009:adverse effects; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010957:Plasmids / Q000235:genetics / Q000494:pharmacology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism*; D012012:Red Nucleus / Q000166:cytology / Q000293:injuries / Q000378:metabolism; D012686:Septal Nuclei / Q000166:cytology / Q000293:injuries / Q000378:metabolism; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000628:therapy*
D000922:Immunotoxins; D018696:Neuroprotective Agents; D019253:Proto-Oncogene Proteins c-bcl-2