Tachykinin-induced stimulation of neuropeptide Y gene expression in the rat arcuate nucleus.
Previous neurocytochemical data indicate the presence of synaptic contacts between tachykinergic terminals and neuropeptide Y (NPY) neurons in the arcuate nucleus of the rat suggesting that tachykinins may regulate NPY neuronal activity. To examine the functional signification of such regulation, the effect of intracerebroventricular administration of neurokinin A on NPY mRNA levels was studied using in situ hybridization. Repeated treatment with NKA (40 microg/day for 3 days) induced a 44% increase in NPPY mRNA expression compared with saline-injected control animals. These results demonstrate a positive effect of tachykinins on NPY gene expression and suggest either a direct or indirect control of arcuate NPY neurons by endogenous tachykinins.
Magoul
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R
Université Sidi Mohammed Ben Abdellah, Faculté des Sciences Fès-Dhar Mehrez, Laboratoire de Physiologie Animale, Fés-Atlas, Morocco.
Tramu
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G
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D017403:In Situ Hybridization; D007276:Injections, Intraventricular; D008297:Male; D015288:Neurokinin A / Q000008:administration & dosage / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009478:Neuropeptide Y / Q000096:biosynthesis* / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D015320:Tachykinins / Q000494:pharmacology*
D009478:Neuropeptide Y; D015320:Tachykinins; D015288:Neurokinin A