title: Association of fasting breath nitrous oxide concentration with gastric juice nitrate and nitrite concentrations and Helicobacter pylori infection.
abstract: Fasting breath nitrous oxide (N2O) concentration was determined in relation to pH, nitrate (NO3-) and nitrite (NO2-) concentrations in gastric juice, and Helicobacter pylori infection in 86 successive patients. N2O was measured with an infrared-photoacoustic analyzer. NO3- and NO2- were measured using the Griess reaction. Fasting breath N2O concentration in controls (87 +/- 21 ppb) was not significantly different from that in patients with gastric ulcer or other gastric lesions. Breath N2O was significantly correlated with gastric NO3- (P < 0.01) and was higher in patients with elevated gastric NO2- (246 +/- 87 ppb) than in patients without NO2- (75 +/- 13 ppb). Breath N2O did not differ significantly between subjects who were positive or negative for H. pylori. In conclusion, fasting breath N2O concentration is in some manner related to intragastric NO3- and NO2- concentrations. The possible use of measuring breath N2O as predictors of cancer needs further research.
authors: Research Center of Health, Physical Fitness and Sports,  Nagoya University School of Medicine, Japan.
authors: T
authors: T
authors: Kondo
authors: T
authors: T
authors: Mitsui
authors: M
authors: M
authors: Kitagawa
authors: Y
authors: Y
authors: Nakae
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests; D005215:Fasting; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D005756:Gastritis / Q000175:diagnosis*; D016481:Helicobacter Infections / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000032:analysis*; D009609:Nitrous Oxide / Q000032:analysis*; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000175:diagnosis; D013276:Stomach Ulcer / Q000175:diagnosis*
chemical_list: D009566:Nitrates; D009609:Nitrous Oxide