title: [Effect of low dose aprotinin on reduction of blood loss after extracorpreal circulation].
abstract: Aprotinin administration during open heart surgery has been reported to reduce blood loss after extracorporeal circulation (ECC). We administered aprotinin to 12 patients undergoing CABG or prosthetic valve replacement. We examined the blood loss, the coagulation, and the fibrinolytic system in comparison with that in non-aprotinin group of 12 patients. In the aprotinin group, 1,000,000 units of aprotinin was infused intravenously before initiation of ECC and mixed with priming volume of ECC. After ECC, 250,000 units/hr was continuously infused until 1 hour after operation. The aprotinin group showed a significantly enhanced level of alpha 2 plasmin inhibitor and a significantly reduced level of plasmin-alpha 2 plasmin inhibitor complex and D-dimer. Post operative blood loss was not different between two groups. Operation time and closure time after heparinneutralization was shorter and postoperative blood use was lower in the aprotinin group. In conclusion, The administration of low dosed of aprotinin suppresses the fibrinolytic system resulting in the reduction of operation and closure time.
authors: Department of Cardiovascular Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors: K
authors: K
authors: Takahashi
authors: S
authors: S
authors: Hoshino
authors: F
authors: F
authors: Iwaya
authors: T
authors: T
authors: Igari
authors: H
authors: H
authors: Satokawa
authors: T
authors: T
authors: Ono
authors: S
authors: S
authors: Takase
authors: T
authors: T
authors: Ogawa
authors: K
authors: K
authors: Satoh
authors: K
authors: K
authors: Satoh
authors: Y
authors: Y
authors: Misawa
authors: K
authors: K
authors: Ishikawa
mesh_terms: D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000008:administration & dosage* / Q000494:pharmacology; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006490:Hemostatics / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged
chemical_list: D006490:Hemostatics; D007611:Aprotinin