Furazolidone- and nitrofurantoin-resistant Helicobacter pylori: prevalence and role of genes involved in metronidazole resistance.
The prevalence of furazolidone, nitrofurantoin, and metronidazole resistance among Helicobacter pylori strains was assessed with 431 clinical isolates. Fifty-two percent were metronidazole resistant, compared to 2% (7 of 431) with resistance to furazolidone and nitrofurantoin. All seven furazolidone- and nitrofurantoin-resistant isolates were also metronidazole resistant. rdxA, frxA, and fdxB knockouts did not result in furazolidone or nitrofurantoin resistance. These data suggest that furazolidone and nitrofurantoin may be good alternatives to metronidazole for treating H. pylori infection.
Kwon
D H
DH
Department of Medicine, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, USA.
Lee
M
M
Kim
J J
JJ
Kim
J G
JG
El-Zaatari
F A
FA
Osato
M S
MS
Graham
D Y
DY
D000892:Anti-Infective Agents, Urinary / Q000494:pharmacology*; D000994:Antitrichomonal Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005664:Furazolidone / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000235:genetics; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology*; D009582:Nitrofurantoin / Q000494:pharmacology*
D000892:Anti-Infective Agents, Urinary; D000994:Antitrichomonal Agents; D008795:Metronidazole; D005664:Furazolidone; D009582:Nitrofurantoin