title: The control of haemolysis during transurethral resection of the prostate when water is used for irrigation: monitoring absorption by the ethanol method.
abstract: OBJECTIVE
  To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption.
  
  
  METHODS
  One hundred patients (46 in Piteå, Sweden and 54 in Uong bi, Vietnam) underwent surgery for benign prostatic hyperplasia (BPH) under an intermittent irrigation technique using water containing 2% ethanol. An expired breath alcohol meter was used to monitor ethanol in the patients' breath every 5 min. Blood samples taken after TURP were assessed for free haemoglobin in 99 patients, and other markers of haemolysis were also evaluated in the Swedish group.
  
  
  RESULTS
  Thirty-two patients had detectable ethanol in their breath. There was a close correlation between the maximum ethanol reading during surgery and the level of free plasma haemoglobin after TURP (r = 0.90, P < 0.001). There was no correlation between the duration of TURP and the free haemoglobin level.
  
  
  CONCLUSIONS
  Monitoring breath ethanol during TURP assesses absorption and so can help to keep control of haemolysis. It is suggested that the value on the alcohol meter should not be allowed to exceed 0.15 (corresponding to a blood ethanol level of 0.15 per thousand), which should maintain the free plasma haemoglobin level at < 1.0 g/L after TURP. Restricting the operative duration per se is not a reliable safety measure.
authors: Department of Surgery, Piteå County Hospital, Piteå, Sweden.
authors: J O
authors: JO
authors: Hultén
authors: V T
authors: VT
authors: Tran
authors: G
authors: G
authors: Pettersson
mesh_terms: D000042:Absorption; D000368:Aged; D001944:Breath Tests; D000431:Ethanol; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000097:blood / Q000601:surgery*; D007507:Therapeutic Irrigation / Q000379:methods; D020728:Transurethral Resection of Prostate / Q000009:adverse effects*; D014867:Water
chemical_list: D014867:Water; D000431:Ethanol