title: Synthesis and biological evaluation of 2,5-dihydropyrazol.
abstract: A novel series of 2,5-dihydropyrazolo[4,3-c]quinolin-3-ones has been prepared. These compounds showed good PDE 4 inhibitory activity and weak affinity for rolipram's binding site. They also exhibited a good anti-inflammatory profile without emetic side effects.
authors: Almirall Prodesfarma, Research Centre, Barcelona, Spain. macrespo@almirallprodesfarma.com
authors: M I
authors: MI
authors: Crespo
authors: J
authors: J
authors: Gràcia
authors: C
authors: C
authors: Puig
authors: A
authors: A
authors: Vega
authors: J
authors: J
authors: Bou
authors: J
authors: J
authors: Beleta
authors: T
authors: T
authors: Doménech
authors: H
authors: H
authors: Ryder
authors: V
authors: V
authors: Segarra
authors: J M
authors: JM
authors: Palacios
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004639:Emetics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008958:Models, Molecular; D010726:Phosphodiesterase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D018927:Anti-Asthmatic Agents; D004639:Emetics; D010726:Phosphodiesterase Inhibitors; D015363:Quinolones