Combined effects of meropenem and aminoglycosides on Pseudomonas aeruginosa in vitro.
To investigate combinations of antibiotics against Pseudomonas aeruginosa, the in vitro effects of combinations of meropenem with each of three aminoglycosides, arbekacin, amikacin and netilmicin, were evaluated using an agar dilution chequerboard technique. The combinations of meropenem and aminoglycosides were effective against almost all P. aeruginosa strains tested, which included meropenem-resistant strains. Increased synergic effects were observed in combinations that included arbekacin or amikacin. None of the combinations had an antagonistic effect. Most of the synergic and additive effects were achieved at clinically relevant concentrations.
Nakamura
A
A
First Department of Internal Medicine, Nagoya City University, Medical School, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. anakamur@med.nagoya-cu.ac.jp
Hosoda
M
M
Kato
T
T
Yamada
Y
Y
Itoh
M
M
Kanazawa
K
K
Nouda
H
H
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D013845:Thienamycins; D000077731:Meropenem