Prevalence and mechanisms of macrolide resistance in Streptococcus pyogenes in Santiago, Chile.
Thirty-two macrolide-resistant Streptococcus pyogenes isolates were found among 594 clinical isolates collected from 1990 to 1998 in Santiago, Chile, for an overall prevalence of 7.2%. Among the 32 resistant isolates, 28 (87.5%) presented the M phenotype and 4 (12. 5%) presented the MLS(B) phenotype. Serotyping and pulsed-field gel electrophoresis analysis showed genetic diversity among the resistant isolates.
Palavecino
E L
EL
Laboratory Services and Department of Public Health, Universidad Catolica, Santiago, Chile.
Riedel
I
I
Berrios
X
X
Bajaksouzian
S
S
Johnson
D
D
Kaplan
E
E
Jacobs
M R
MR
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002677:Chile / Q000453:epidemiology; D002981:Clindamycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D016521:Electrophoresis, Gel, Pulsed-Field; D004917:Erythromycin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D004917:Erythromycin