title: Long-term changes in middle latency response and evidence of retrograde degeneration in the medial geniculate body after auditory cortical ablation in cats.
abstract: Short- and long-term changes in the middle latency response (MLR) after bilateral ablation of the auditory cortices were studied in awake cats. The amplitude of the negative peak with a latency of about 15 ms (NA) decreased to 60% of the original value 1 week after ablation (short-term change). In the long term, i.e. 11-30 months, NA either decreased further (decreased group) or remained unchanged (non-decreased group). A histological study with light microscopy revealed degeneration of neurons in the ventral nucleus of the medial geniculate body (MGv) in the decreased group, whereas the neurons in this region were preserved in the non-decreased group. This study suggests that long-term changes in NA reflect retrograde degeneration in the MGv after auditory cortical ablation.
authors: Department of Otolaryngology, Teikyo University School of Medicine, Japan.
authors: K
authors: K
authors: Yamada
authors: K
authors: K
authors: Kaga
authors: T
authors: T
authors: Tsuzuku
authors: A
authors: A
authors: Uno
mesh_terms: D000818:Animals; D001284:Atrophy / Q000473:pathology; D001306:Auditory Pathways / Q000473:pathology* / Q000601:surgery; D002415:Cats; D004567:Electrodes, Implanted; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005829:Geniculate Bodies / Q000473:pathology* / Q000601:surgery*; D007245:Inferior Colliculi / Q000502:physiology* / Q000601:surgery; D009410:Nerve Degeneration / Q000473:pathology*; D009475:Neurons, Afferent / Q000473:pathology; D011930:Reaction Time / Q000502:physiology; D013995:Time; D013997:Time Factors