Randomised, prospective, controlled trial comparing tropisetron with metoclopramide and placebo in controlling postoperative nausea and vomiting.
OBJECTIVE
To compare the results of Tropisetron, Metoclopramide and placebo on postoperative nausea and vomiting in patients undergoing minilaparotomy cholecystectomy.


METHODS
Patients operated for minilaparotomy cholecystectomy in two private hospitals in Karachi.


METHODS
Fifty consecutive patients of all ages and both sex who had simple cholelithiasis and underwent minilaparotomy cholecystectomy by a single surgeon.


METHODS
Postoperative nausea and vomiting (PONV) at 2 hours and within 24 hours and requirement of rescue antiemetic.


RESULTS
Tropisetron was better than Metoclopramide and placebo in controlling postoperative nausea and vomiting.


CONCLUSIONS
Tropisetron when given at induction at a dose of 2 mg. intravenously prevents PONV better than Metoclopramide and placebo in 2 hours and 24 hours. It also reduces the need for rescue antiemetic significantly.
Muhammad
S R
SR
Department of Surgery, Baqai Medical University, Karachi.
Abbas
S Z
SZ
Abbas
S Q
SQ
D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage*; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000175:diagnosis / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D000077526:Tropisetron
D000932:Antiemetics; D007211:Indoles; D000077526:Tropisetron; D008787:Metoclopramide