title: T cell differentiation: a mechanistic view.
abstract: It has recently become clear that cytokine expression by T cells involves epigenetic changes in chromatin structure, locus accessibility and DNA methylation that occur during differentiation of naive T cells into mature effector T cells. These changes require the coordinate actions of antigen- and cytokine-induced transcription factors, chromatin remodeling complexes, histone-modifying enzymes and subset-specific transcription factors.
authors: Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. avni@cbr.harvard.edu
authors: O
authors: O
authors: Avni
authors: A
authors: A
authors: Rao
mesh_terms: D000818:Animals; D002843:Chromatin; D006801:Humans; D019891:Leukopoiesis; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000276:immunology
chemical_list: D002843:Chromatin; D014157:Transcription Factors