Developmental seizures induced by common early-life insults: short- and long-term effects on seizure susceptibility.
The immature brain is highly susceptible to seizures induced by a variety of insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults induce a hyperexcitable state in a previously normal brain. Here we evaluate the epileptogenic effects of seizure-inducing stimuli on the developing brain, and the age and regional specificity of these effects.
Jensen
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Children's Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA. Jensen@a1.tch.harvard.edu
Baram
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TZ
D000367:Age Factors; D001921:Brain / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D015984:Causality; D002648:Child; D002675:Child, Preschool; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D007223:Infant; D007231:Infant, Newborn; D012640:Seizures / Q000150:complications* / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D003294:Seizures, Febrile / Q000150:complications / Q000209:etiology / Q000473:pathology / Q000503:physiopathology