Ophthalmic manifestations of neonatal onset multisystem inflammatory disease.
OBJECTIVE
To report the ophthalmic manifestations of neonatal onset multisystem inflammatory disease, a recently recognized, rare systemic disorder characterized by the triad of arthropathy, rash, and abnormal central nervous system development.


METHODS
Case report.


RESULTS
A 2-year-old female with neonatal onset multisystem inflammatory disease presented with visual acuity of fix and follow with each eye, bilateral optic nerve head pallor and gliosis, as well as marked sheathing of the peripapillary vessels. No vitreous inflammation or macular edema was found. Visual acuity was stable from the neonatal period through the 3 months of follow-up after the changes involving the optic nerve heads and peripapillary vessels were observed (a total of 33 months).


CONCLUSIONS
This report provides a description of the ocular manifestations of neonatal onset multisystem inflammatory disease and supports earlier suggestions that swelling of the optic nerve heads can occur. In this case, optic nerve head pallor may have been a sequela of such swelling. The pathogenesis of neonatal onset multisystem inflammatory disease is unknown.
Kuo
I C
IC
Proctor Foundation and the Department of Ophthalmology, University of California, San Francisco, California, USA. ickuo@jhmi.edu
Fan
J
J
Cunningham
E T
ET
D002675:Child, Preschool; D005076:Exanthema / Q000175:diagnosis*; D005260:Female; D016575:Hidradenitis / Q000175:diagnosis*; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis*; D009421:Nervous System Malformations / Q000175:diagnosis*; D009898:Optic Disk / Q000098:blood supply / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012171:Retinal Vessels / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity