The molecular pharmacology of CGRP and related peptide receptor subtypes.
Calcitonin gene-related peptides (alpha and beta isoforms), better known as CGRPalpha and CGRPbeta, were isolated twenty years ago. In fact, these were the first peptides to be characterized using a molecular cloning strategy, which is not the traditional approach of biochemical extraction and purification. Paradoxically, progress in the characterization of CGRP receptor subtypes has been extremely slow as a result of difficulties in their cloning and the lack of selective receptor subtype agonists and antagonists. However, exciting progress has been made overthe pasttwo years and is briefly reviewed here.
Juaneda
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C
Douglas Hospital Research Centre and Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. juachr@douglas.mcgill.ca
Dumont
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Y
Quirion
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R
D000595:Amino Acid Sequence; D000818:Animals; D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D006801:Humans; D008969:Molecular Sequence Data; D010879:Piperazines / Q000378:metabolism / Q000494:pharmacology; D011799:Quinazolines / Q000378:metabolism / Q000494:pharmacology; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000819:agonists / Q000145:classification* / Q000502:physiology; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide / Q000819:agonists / Q000037:antagonists & inhibitors / Q000145:classification / Q000502:physiology
D000077221:Calcitonin Gene-Related Peptide Receptor Antagonists; D010879:Piperazines; D011799:Quinazolines; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide; C406305:olcegepant