Chiral sulfonamide induced enantioselective protonation of samarium enolate in the reaction of alpha,beta-unsaturated ester with ketone
Good enantioselectivity (up to 84% ee) has been achieved in the formation of alpha,gamma-substituted-gamma-butyrolactone by the SmI(2)-mediated reductive coupling of ketones with methyl methacrylate using various chiral proton sources.
Wang
W
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenlin Lu, Shanghai 200032, P. R. China.
Xu
MH
Lei
XS
Lin
GQ