Clinical drug development--practical issues in clinical pharmacology studies.
BACKGROUND
Clinical pharmacology refers to the study of the safety, pharmacodynamic activity, mechanism of action, pharmacokinetics, metabolism and excretion of a drug in man.


METHODS
Selected review of topics that provide guidance on practical issues for researchers conducting non-therapeutic investigational research in humans.


RESULTS
Close attention to the issues highlighted is needed to ensure successful research in this area of drug development. Resources dedicated to the discipline can logically optimise efficiency and outcome.


CONCLUSIONS
There is increasing opportunity for clinical pharmacological research, offering an interesting career option to young physicians.
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Lilly-NUS Centre for Clinical Pharmacology Pte Ltd, Level 6 Clinical Research Centre (MD11), National University of Singapore, 10 Medical Drive, Singapore 117597.
D002986:Clinical Trials as Topic; D017321:Clinical Trials, Phase I as Topic; D004353:Drug Evaluation, Preclinical; D015507:Drugs, Investigational / Q000191:economics; D006801:Humans; D018579:Patient Selection; D010601:Pharmacology, Clinical; D012107:Research Design
D015507:Drugs, Investigational