title: Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia.
abstract: The production of antimicrobial peptides is an important aspect of host defense in multicellular organisms. In Drosophila, seven antimicrobial peptides with different spectra of activities are synthesized by the fat body during the immune response and secreted into the hemolymph. Using GFP reporter transgenes, we show here that all seven Drosophila antimicrobial peptides can be induced in surface epithelia in a tissue-specific manner. The imd gene plays a critical role in the activation of this local response to infection. In particular, drosomycin expression, which is regulated by the Toll pathway during the systemic response, is regulated by imd in the respiratory tract, thus demonstrating the existence of distinct regulatory mechanisms for local and systemic induction of antimicrobial peptide genes in Drosophila.
authors: Centre de Génétique Moléculaire du CNRS, 91198 Gif-sur-Yvette, France.
authors: P
authors: P
authors: Tzou
authors: S
authors: S
authors: Ohresser
authors: D
authors: D
authors: Ferrandon
authors: M
authors: M
authors: Capovilla
authors: J M
authors: JM
authors: Reichhart
authors: B
authors: B
authors: Lemaitre
authors: J A
authors: JA
authors: Hoffmann
authors: J L
authors: JL
authors: Imler
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000276:immunology* / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000276:immunology*; D029721:Drosophila Proteins; D005786:Gene Expression Regulation / Q000276:immunology*; D017344:Genes, Insect; D017930:Genes, Reporter; D006026:Glycoside Hydrolases / Q000276:immunology; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000276:immunology; D009928:Organ Specificity; D014162:Transfection
chemical_list: D000890:Anti-Infective Agents; D029721:Drosophila Proteins; D019476:Insect Proteins; C091227:DRS protein, Drosophila; D006026:Glycoside Hydrolases; C091051:glucan 1,6-alpha-isomaltosidase