title: Applications of vascular occlusion diminish disuse atrophy of knee extensor muscles.
abstract: OBJECTIVE
  We have previously shown that the combination of low-intensity resistive exercise and moderate vascular occlusion induces in humans a marked increase in growth hormone secretion and muscular hypertrophy. The present study investigated the effects of vascular occlusion on the size of thigh muscles in patients who underwent an operation for the reconstruction of the anterior cruciate ligament to see whether it attenuates the disuse muscular atrophy without any exercise combined.
  
  
  METHODS
  Two sessions of occlusive stimulus, each consisting of five repetitions of vascular occlusion (mean maximal pressure, 238 mm Hg) for 5 min and the release of occlusion for 3 min, were applied daily to the proximal end of the thigh from 3rd to 14th days after the operation. Changes in the cross-sectional area (CSA) of thigh muscles were analyzed with magnetic resonance images taken on the 3rd and 14th day after the operation.
  
  
  RESULTS
  Without occlusive stimulus (control), the CSAs of knee extensors and flexors decreased by 20.7 +/- 2.2% and 11.3 +/- 2.6% (mean +/- SEM, N = 8), whereas with the occlusive stimulus, they decreased by 9.4 +/- 1.6% and 9.2 +/- 2.6% (N = 8), respectively. The relative decrease in CSA of knee extensors was significantly (P < 0.05) larger in the control group than in the experimental group.
  
  
  CONCLUSIONS
  The results indicate that the occlusive stimulus effectively diminishes the postoperation disuse atrophy of knee extensors.
authors: Physiology Division, Yokohama City Sports Medical Center, Japan.
authors: Y
authors: Y
authors: Takarada
authors: H
authors: H
authors: Takazawa
authors: N
authors: N
authors: Ishii
mesh_terms: D000328:Adult; D000070598:Anterior Cruciate Ligament Injuries; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000473:pathology*; D007719:Knee Joint / Q000098:blood supply* / Q000473:pathology*; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009133:Muscular Atrophy / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011184:Postoperative Period; D012039:Regional Blood Flow; D013848:Thigh