High-frequency oscillations in human posterior tibial somatosensory evoked potentials are enhanced in patients with Parkinson's disease and multiple system atrophy.
High-frequency oscillations (HFOs) and the underlying P37 primary somatosensory response evoked by posterior tibial nerve stimulation were recorded in patients with Parkinson's disease (PD) and in those with multiple system atrophy (MSA), as well as in normal controls. In order to increase the signal-to-noise ratio, we averaged a large number of responses (9998 epochs) with a high sampling rate (20 kHz per channel). HFOs were extracted by filtering the wide band-pass recording of the P37 potential with a 600-900 Hz band-pass filter. High-amplitude HFOs were observed in both the PD and MSA patients. Furthermore, the duration of illness was positively correlated with the amplitude of HFOs. The results suggest that HFOs are enhanced by dysfunction of the basal ganglia.
Inoue
K
K
Third Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi Minami-ku, 734-7551, Hiroshima, Japan. kenin_97@yahoo.com
Hashimoto
I
I
Nakamura
S
S
D000368:Aged; D000369:Aged, 80 and over; D001479:Basal Ganglia / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000175:diagnosis* / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology; D010507:Periodicity; D013979:Tibial Nerve / Q000502:physiology*