Imaging for staging bladder cancer: a clinical study of intravenous 111indium-labelled anti-MUC1 mucin monoclonal antibody C595.
OBJECTIVE
To investigate the clinical application of an 111In-labelled anti-MUC1 mucin monoclonal antibody (mAb) imaging for staging invasive bladder cancer.


METHODS
Indirect immunohistochemistry was used to confirm the expression of the MUC1 target antigen by metastatic tumours. Twelve patients with bladder cancer (two with superficial and 10 with locally invasive/metastatic disease) underwent planar gamma-scintigraphy 48 h after an intravenous injection with 111In-labelled anti-MUC1 mucin mAb C595.


RESULTS
No bladder uptake was detected in the two patients with superficial disease, but scintigraphy showed primary and recurrent bladder tumours and metastases in nine of the remaining 10 patients with invasive disease. In three patients additional staging information was obtained from the mAb imaging which would have altered patient management. There were no reported side-effects.


CONCLUSIONS
This study confirmed the ability of the mAb technique to detect both primary and recurrent invasive bladder tumours and distant metastases. Some lesions shown by mAb imaging were not detected by other methods. The use of mAb imaging has the potential to improve clinical staging and assist in selecting those patients most likely to benefit from radical therapy.
Hughes
O D
OD
Department of Urology, City Hospital, Nottingham, UK.
Perkins
A C
AC
Frier
M
M
Wastie
M L
ML
Denton
G
G
Price
M R
MR
Denley
H
H
Bishop
M C
MC
D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007205:Indium Radioisotopes; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009367:Neoplasm Staging / Q000379:methods; D010446:Peptide Fragments; D011877:Radionuclide Imaging; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging*
D007205:Indium Radioisotopes; C116055:MUC1 tandem repeat peptide; D018396:Mucin-1; D010446:Peptide Fragments