Case report: carcinoma of the extraorbital lacrimal gland in a female Fischer 344 rat.
A large subcutaneous mass was observed at necropsy in the right neck area of a 95-week-old female Fischer 344 rat that served as an untreated control animal in a 2-year carcinogenicity study. Formalin-fixed, paraffin-embedded sections of the mass were stained with hematoxylin and eosin along with the immunohistochemical biomarkers lactoperoxidase, catalase, and amylase. Based on its histomorphological and immunohistochemical features, the lesion was diagnosed as a carcinoma of the extraorbital lacrimal gland.
Heath
J E
JE
Southern Research Institute, Birmingham, Alabama 35255, USA. heath@serquest.com
Rahemtullah
F
F
Fine
W D
WD
D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D000681:Amylases / Q000032:analysis; D000818:Animals; D002374:Catalase / Q000032:analysis; D005134:Eye Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D007765:Lacrimal Apparatus / Q000201:enzymology / Q000473:pathology*; D007766:Lacrimal Apparatus Diseases / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D007784:Lactoperoxidase / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344; D012376:Rodent Diseases / Q000473:pathology*
D007784:Lactoperoxidase; D002374:Catalase; D000681:Amylases