Diazepam induces FGF-2 mRNA in the hippocampus and striatum.
starting by 6 h following diazepam injection and returning to approximately control values by 24 h. In situ hybridization showed elevated FGF-2 mRNA labeling in the hippocampal formation, mostly in the pyramidal layer of the CA1 and CA2 subfields and in the dentate gyrus hilar region. These results indicate that diazepam treatment up-regulates FGF-2 expression in select regions of the brain and suggest that GABA may promote neuroplasticity in concert with FGF-2.
Gómez-Pinilla
F
F
Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA. fgomezpi@ucla.edu
Dao
L
L
Choi
J
J
Ryba
E A
EA
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000235:genetics*; D018757:GABA Modulators / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D018757:GABA Modulators; D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2; D003975:Diazepam