title: The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human immunodeficiency virus infection.
abstract: BACKGROUND
  As human immunodeficiency virus (HIV) infection primarily impairs cellular immunity, the immune responses of HIV-infected individuals to tuberculous bacilli may be inadequate. The features of pulmonary and abdominal tuberculosis evident in HIV-positive (HIV-P) patients with severe immunosuppression are markedly different from those seen in HIV-negative (HIV-N) patients. However, such differences have not been reported in tuberculous meningitis (TBM). Here, we therefore compared the clinical, radiological and pathological features of TBM in patients with and without HIV infection.
  
  
  RESULTS
  Twenty-two HIV-P patients with TBM, seen over 5 years, were studied and compared with 31 HIV-N patients with TBM. Although clinical features were similar, cognitive dysfunction was more common amongst the HIV-P group. Pathological features were markedly different in the HIV-P group reflecting severely reduced and atypical inflammatory response, and extensive vasculopathy. This manifested as absence or minimal meningeal enhancement and absence of communicating hydrocephalus on CT scan in HIV-P patients. Mortality was higher within the HIV-P group and depressed levels of consciousness and hemiplegia were associated with poor prognosis.
  
  
  CONCLUSIONS
  The clinical, radiological and pathological features of TBM in HIV-P patients are distinctly different from those without HIV infection; a finding previously unreported.
authors: Department of Neurology, Grant Medical College & JJ Group of Hospitals, 400 008, Mumbai, India. smkatrak@bom2.vsn1.net.in
authors: S M
authors: SM
authors: Katrak
authors: P K
authors: PK
authors: Shembalkar
authors: S R
authors: SR
authors: Bijwe
authors: L D
authors: LD
authors: Bhandarkar
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D002533:Cerebral Angiography; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000378:metabolism; D003710:Demography; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014390:Tuberculosis, Meningeal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality / Q000473:pathology*