title: MIP-2 recruits NKT cells to the spleen during tolerance induction.
abstract: Peripheral tolerance occurs after intraocular administration of Ag and is dependent on an increase in splenic NKT cells. New data here show that macrophage inflammatory protein-2 (MIP-2) is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection.
authors: Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA.
authors: D E
authors: DE
authors: Faunce
authors: K H
authors: KH
authors: Sonoda
authors: J
authors: J
authors: Stein-Streilein
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000276:immunology; D000941:Antigens / Q000008:administration & dosage; D000943:Antigens, Differentiation / Q000096:biosynthesis; D017252:CD3 Complex / Q000096:biosynthesis; D054426:Chemokine CXCL2; D018925:Chemokines / Q000096:biosynthesis / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000235:genetics / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance / Q000235:genetics; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D013154:Spleen / Q000166:cytology* / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics / Q000276:immunology
chemical_list: D000941:Antigens; D000943:Antigens, Differentiation; D017252:CD3 Complex; D054426:Chemokine CXCL2; D018925:Chemokines; C404915:Cxcl2 protein, mouse; C036763:monocyte-macrophage differentiation antigen; D010047:Ovalbumin