title: Additional chromosomal abnormalities in patients with acute promyelocytic leukaemia (APL) do not confer poor prognosis: results of APL 93 trial.
abstract: In spite of the recent improvement in the outcome of acute promyelocytic leukaemia (APL) with treatment combining all trans retinoic acid (ATRA) and chemotherapy (CT), some patients with this disease still have a poor outcome. The prognostic significance of chromosomal abnormalities in addition to t(15;17) in APL is uncertain. We examined the prognostic significance of secondary chromosomal changes in 292 patients included in a European trial who were treated with ATRA and CT. The incidence of chromosomal abnormalities in addition to t(15;17) was 26% and trisomy 8 was the most frequent secondary change (46% of the cases with secondary changes). No significant differences were seen with regard to age, sex, initial white blood cell count, % of circulating blasts, platelet count, fibrinogen level and incidence of microgranular variants between patients with or without additional rearrangements. Outcome was also similar between patients with t(15;17) alone and patients with t(15;17) and other clonal abnormalities for complete remission (92% vs. 93% respectively), event-free survival at 2 years (76.1% vs. 78.1% respectively), relapse at 2 years (16.7% vs. 11.6% respectively) and overall survival at 2 years (79.9% vs. 79.5% respectively). Analysis according to the type of induction treatment (ATRA followed by CT or ATRA plus CT) or the type of maintenance treatment (with ATRA, low-dose CT or both) also failed to show any difference between the two groups. Thus, in a large cohort of APL patients treated with ATRA and CT, additional chromosomal abnormalities had no impact on prognosis.
authors: S
authors: S
authors: De Botton
authors: S
authors: S
authors: Chevret
authors: M
authors: M
authors: Sanz
authors: H
authors: H
authors: Dombret
authors: X
authors: X
authors: Thomas
authors: A
authors: A
authors: Guerci
authors: M
authors: M
authors: Fey
authors: C
authors: C
authors: Rayon
authors: F
authors: F
authors: Huguet
authors: J J
authors: JJ
authors: Sotto
authors: C
authors: C
authors: Gardin
authors: P
authors: P
authors: Cony Makhoul
authors: P
authors: P
authors: Travade
authors: E
authors: E
authors: Solary
authors: N
authors: N
authors: Fegueux
authors: D
authors: D
authors: Bordessoule
authors: J
authors: J
authors: San Miguel
authors: H
authors: H
authors: Link
authors: B
authors: B
authors: Desablens
authors: A
authors: A
authors: Stamatoullas
authors: E
authors: E
authors: Deconinck
authors: K
authors: K
authors: Geiser
authors: U
authors: U
authors: Hess
authors: F
authors: F
authors: Maloisel
authors: S
authors: S
authors: Castaigne
authors: C
authors: C
authors: Preudhomme
authors: C
authors: C
authors: Chomienne
authors: L
authors: L
authors: Degos
authors: P
authors: P
authors: Fenaux
mesh_terms: D000328:Adult; D018943:Anthracyclines / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002869:Chromosome Aberrations; D002881:Chromosomes, Human, Pair 12; D002884:Chromosomes, Human, Pair 15; D002885:Chromosomes, Human, Pair 16; D002886:Chromosomes, Human, Pair 17; D002891:Chromosomes, Human, Pair 21; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D002899:Chromosomes, Human, Pair 9; D015331:Cohort Studies; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012074:Remission Induction; D015996:Survival Rate; D014178:Translocation, Genetic; D014212:Tretinoin / Q000627:therapeutic use; D014314:Trisomy
chemical_list: D018943:Anthracyclines; D003561:Cytarabine; D014212:Tretinoin; D003630:Daunorubicin