The CD81 expression in liver in hepatocellular carcinoma.
The expression of CD81, a cell receptor for hepatitis C virus, was examined on cancer cells in hepatocellular carcinoma (HCC) C (n=29) to clarify its clinical role. CD81 was expressed on hepatocyte membrane in non-tumor portions in all patients, however, this was not stained on the cancer cell membranes in 6 of 29. Reverse transcriptase-PCR revealed that CD81 gene expression was not detected in the tumorous portions in 3 of 7 samples. The loss of CD81 was prominent in poorly differentiated HCC (5 of 8) and extrahepatic metastasis patients (6 of 8). The loss of CD81 is associated with differentiation and metastasis of HCC.
Inoue
G
G
Third Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.
Horiike
N
N
Onji
M
M
D000368:Aged; D015703:Antigens, CD / Q000032:analysis / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D060225:Tetraspanin 28
D015703:Antigens, CD; C554798:CD81 protein, human; D008565:Membrane Proteins; D012333:RNA, Messenger; D060225:Tetraspanin 28