[Cutaneous polyarteritis nodosa associated with streptococcal infection in a child and a review of the literature].
Polyarteritis nodosa (PAN) is a multisystem inflammatory disease associated with necrosis of small and medium arteries. It can occur in a systemic form with manifestations in skin, joints, heart, nervous system, gastrointestinal tracts, lungs and kidneys. It is relatively rare in adults and even more in children. It may be divided into a cutaneous form (C-PAN) and a more generalized form (G-PAN). Usually C-PAN is thought to run a benign course. But some cases were reported to run chronic courses and be diagnosed G-PAN. It has been reported that some adults with PAN are related to HBV infection. On the other hand most children with PAN had upper respiratory infections some with streptococcal infections. We described a 5-year-old boy who was suffering from high fever, joint pain, subcutaneous nodular and livedo reticularis. We diagnosed him C-PAN by examination and clinical course. Anti-streptolysin O (ASO) and anti-streptokinase (ASK) increased and we suspected that C-PAN followed after streptococcal infection. We reviewed the literatures of C-PAN and streptococcal infection in childhood. Streptococcal infection has been implicated by a positive throat swab or an increase in ASO. There were 25 cases (75.7%) which were thought to be related with prior streptococcal infection in 33 cases. We thought that C-PAN may be associated with streptcoccal infection in childhood.
Sasamoto
M
M
Department of Paediatrics, Tokyo Medical University Hospital.
Shigeta
Y
Y
Hisashi
K
K
Kashiwagi
Y
Y
Koishi
H
H
Kobayashi
K
K
Takekuma
K
K
Hoshika
A
A
D002675:Child, Preschool; D006801:Humans; D008297:Male; D010488:Polyarteritis Nodosa / Q000188:drug therapy / Q000209:etiology*; D012141:Respiratory Tract Infections / Q000150:complications* / Q000188:drug therapy; D013290:Streptococcal Infections / Q000150:complications* / Q000188:drug therapy; D016896:Treatment Outcome