From structure to function: approaches and limitations.
This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a protein in vivo will only be possible by including other results, such as data on expression and localization.
Thornton
J M
JM
Biochemistry & Molecular Biology Dept, University College, London, UK. thornton@biochem.ucl.ac.uk
Todd
A E
AE
Milburn
D
D
Borkakoti
N
N
Orengo
C A
CA
D001665:Binding Sites; D019992:Databases as Topic; D015195:Drug Design; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D013329:Structure-Activity Relationship
D011506:Proteins