Allo-tolerance and allorejection responses ex vivo.
Spleen cells from fully immune competent mice show different intracellular STAT responses to alloantigen. Cells from mice primed to accept the alloantigen have low STAT 6 and fragmented STAT 4, compared to cells from mice primed to reject the same alloantigen.
Moffatt
S D
SD
Department of Surgery, University of Cambridge, Addenbrookes Hospital, UK.
Metcalfe
S
S
D000818:Animals; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000502:physiology; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D007108:Immune Tolerance; D007519:Isoantigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008894:Milk Proteins; D050794:STAT1 Transcription Factor; D050797:STAT4 Transcription Factor; D050799:STAT5 Transcription Factor; D050800:STAT6 Transcription Factor; D016038:Skin Transplantation / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D015534:Trans-Activators / Q000502:physiology; D023001:Transplantation Tolerance; D014184:Transplantation, Homologous / Q000276:immunology
D004268:DNA-Binding Proteins; D007519:Isoantigens; D008894:Milk Proteins; D050794:STAT1 Transcription Factor; D050797:STAT4 Transcription Factor; D050799:STAT5 Transcription Factor; D050800:STAT6 Transcription Factor; C494080:Stat1 protein, mouse; C494091:Stat4 protein, mouse; C494100:Stat6 protein, mouse; D015534:Trans-Activators