Frequency and kinetics of polyclonal and clonal B cells in the peripheral blood of patients being treated for multiple myeloma.
Recent studies concerning the numbers of circulating clonal B cells in patients with multiple myeloma (MM) have reported conflicting data regarding the exact level and phenotype of clonal B cells and their response to treatment. In this report we document that the peripheral blood tumor burden at presentation was reduced by induction therapy to a low level, regardless of the initial tumor burden. However, the residual clonal compartment persisted before and after transplant. The level of clonal cells showed no correlation with CD19(+) cell levels. In a single patient with MM, high numbers of phenotypically aberrant clonal cells with altered CD19 expression were identified. (Blood. 2000;96:4357-4359)
Rasmussen
T
T
Department of Hematology L, Herlev Hospital, University of Copenhagen, Herlev, Denmark. thra@herlevhosp.kbhamt.dk
Jensen
L
L
Honoré
L
L
Johnsen
H E
HE
D018941:Antigens, CD19 / Q000097:blood; D000943:Antigens, Differentiation / Q000097:blood*; D000951:Antigens, Neoplasm / Q000097:blood*; D016175:B-Lymphocyte Subsets / Q000473:pathology*; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000097:blood*; D001773:Blood Cells / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology; D002454:Cell Differentiation; D002999:Clone Cells / Q000473:pathology; D015331:Cohort Studies; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008969:Molecular Sequence Data; D009101:Multiple Myeloma / Q000097:blood* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology / Q000628:therapy; D009194:Myeloma Proteins / Q000235:genetics; D009360:Neoplastic Cells, Circulating; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018941:Antigens, CD19; D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D007143:Immunoglobulin Heavy Chains; D009194:Myeloma Proteins