title: Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials.
abstract: OBJECTIVE
  To obtain reliable estimates of the effects of neuraxial blockade with epidural or spinal anaesthesia on postoperative morbidity and mortality.
  
  
  METHODS
  Systematic review of all trials with randomisation to intraoperative neuraxial blockade or not.
  
  
  METHODS
  141 trials including 9559 patients for which data were available before 1 January 1997. Trials were eligible irrespective of their primary aims, concomitant use of general anaesthesia, publication status, or language. Trials were identified by extensive search methods, and substantial amounts of data were obtained or confirmed by correspondence with trialists.
  
  
  METHODS
  All cause mortality, deep vein thrombosis, pulmonary embolism, myocardial infarction, transfusion requirements, pneumonia, other infections, respiratory depression, and renal failure.
  
  
  RESULTS
  Overall mortality was reduced by about a third in patients allocated to neuraxial blockade (103 deaths/4871 patients versus 144/4688 patients, odds ratio=0.70, 95% confidence interval 0.54 to 0.90, P=0. 006). Neuraxial blockade reduced the odds of deep vein thrombosis by 44%, pulmonary embolism by 55%, transfusion requirements by 50%, pneumonia by 39%, and respiratory depression by 59% (all P<0.001). There were also reductions in myocardial infarction and renal failure. Although there was limited power to assess subgroup effects, the proportional reductions in mortality did not clearly differ by surgical group, type of blockade (epidural or spinal), or in those trials in which neuraxial blockade was combined with general anaesthesia compared with trials in which neuraxial blockade was used alone.
  
  
  CONCLUSIONS
  Neuraxial blockade reduces postoperative mortality and other serious complications. The size of some of these benefits remains uncertain, and further research is required to determine whether these effects are due solely to benefits of neuraxial blockade or partly to avoidance of general anaesthesia. Nevertheless, these findings support more widespread use of neuraxial blockade.
authors: Clinical Trials Research Unit, Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand.
authors: A
authors: A
authors: Rodgers
authors: N
authors: N
authors: Walker
authors: S
authors: S
authors: Schug
authors: A
authors: A
authors: McKee
authors: H
authors: H
authors: Kehlet
authors: A
authors: A
authors: van Zundert
authors: D
authors: D
authors: Sage
authors: M
authors: M
authors: Futter
authors: G
authors: G
authors: Saville
authors: T
authors: T
authors: Clark
authors: S
authors: S
authors: MacMahon
mesh_terms: D000767:Anesthesia, Epidural / Q000401:mortality*; D000775:Anesthesia, Spinal / Q000401:mortality*; D006801:Humans; D011183:Postoperative Complications / Q000401:mortality*; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors