[Effect of experimental herpesvirus infection on morphofunctional state of mast cells].
Mast cells are involved in the reaction of the organism to herpesvirus infection, which manifests by changes in their count, morphology, and function. The onset of infection is characterized by primary activation of mast cells, the peak of disease by suppressed function, and convalescence by secondary activation and stabilization of cell morphology and function. Viral infection running in the presence of immunosuppression caused by cyclophosphamide is characterized by deep persistent suppression of the morphology and functions of mast cells at the peak of disease.
Chubik
M P
MP
Krasnozhenov
E P
EP
Zvereva
I F
IF
Karpova
M R
MR
D000818:Animals; D015550:Cell Degranulation; D003520:Cyclophosphamide / Q000494:pharmacology; D006561:Herpes Simplex / Q000473:pathology* / Q000503:physiopathology*; D018259:Herpesvirus 1, Human; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008407:Mast Cells / Q000473:pathology* / Q000502:physiology* / Q000821:virology; D051379:Mice
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide