title: Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21.
abstract: Childhood-onset schizophrenia (COS) is defined by the development of first psychotic symptoms by age 12. While recruiting patients with COS refractory to conventional treatments for a trial of atypical antipsychotic drugs, we discovered a unique case who has a familial t(1;7)(p22;q21) reciprocal translocation and onset of psychosis at age 9. The patient also has symptoms of autistic disorder, which are usually transient before the first psychotic episode among 40-50% of the childhood schizophrenics but has persisted in him even after the remission of psychosis. Cosegregating with the translocation, among the carriers in the family available for the study, are other significant psychopathologies, including alcohol/drug abuse, severe impulsivity, and paranoid personality and language delay. This case may provide a model for understanding the genetic basis of schizophrenia or autism. Here we report the progress toward characterization of genomic organization across the translocation breakpoint at 7q21. The polymorphic markers, D7S630/D7S492 and D7S2410/D7S646, immediately flanking the breakpoint, may be useful for further confirming the genetic linkage for schizophrenia or autism in this region. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:749-753, 2000. Published 2000 Wiley-Liss, Inc.
authors: Child Psychiatry, National Institute of Mental Health, Bethesda, Maryland 20892-4405, USA. wlyan@helix.nih.gov
authors: W L
authors: WL
authors: Yan
authors: X Y
authors: XY
authors: Guan
authors: E D
authors: ED
authors: Green
authors: R
authors: R
authors: Nicolson
authors: T K
authors: TK
authors: Yap
authors: J
authors: J
authors: Zhang
authors: L K
authors: LK
authors: Jacobsen
authors: D M
authors: DM
authors: Krasnewich
authors: S
authors: S
authors: Kumra
authors: M C
authors: MC
authors: Lenane
authors: P
authors: P
authors: Gochman
authors: P J
authors: PJ
authors: Damschroder-Williams
authors: L E
authors: LE
authors: Esterling
authors: R T
authors: RT
authors: Long
authors: B M
authors: BM
authors: Martin
authors: E
authors: E
authors: Sidransky
authors: J L
authors: JL
authors: Rapoport
authors: E I
authors: EI
authors: Ginns
mesh_terms: D001321:Autistic Disorder / Q000235:genetics* / Q000473:pathology; D002648:Child; D019457:Chromosome Breakage / Q000235:genetics; D002876:Chromosomes, Bacterial; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D020451:Contig Mapping; D004247:DNA / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D004247:DNA