Transcriptional regulation by cAMP in the heart.
Stimulation of the cAMP-dependent signalling pathway by beta-adrenergic catecholamines is an important physiological mechanism to increase contractile force in the heart. In addition to this, long-term beta-adrenergic stimulation by elevated catecholamines also influences the expressional control of functionally relevant cardiac regulatory proteins in human heart failure. The regulation of transcription by the cAMP-response element (CRE) is an important mechanism for a cAMP-mediated control of gene expression involved e.g. in spermiogenesis and memory/learning processes. This article discusses recent data leading to the hypothesis that this mechanism also contributes to altered gene regulation in heart failure.
Müller
F U
FU
Institut für Pharmakologie und Toxikologie, Westfälische Wilhelms-Universität, Münster, Germany. mullerf@uni-muenster.de
Neumann
J
J
Schmitz
W
W
D000818:Animals; D002395:Catecholamines / Q000502:physiology; D000242:Cyclic AMP / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006331:Heart Diseases / Q000235:genetics / Q000503:physiopathology*; D006333:Heart Failure / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D009200:Myocardial Contraction; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D014158:Transcription, Genetic
D002395:Catecholamines; D017362:Cyclic AMP Response Element-Binding Protein; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP