[Neonatal alloimmune thrombocytopenia due to a rare anti-HPA-1b antibody].
Foetal and neonatal alloimmune thrombocytopenia is caused by transplacental transfer of antibodies directed against platelet antigens and affects approximately 1 in 1000-2500 neonates. Clinically relevant complications are the intracranial haemorrhages that occur in 10-20% of cases. 20 platelet antigen systems are currently known. However, immunisation is most frequently seen against two of these (HPA-1a and HPA-5b). Treatment options include transfusion of compatible or, if these are not available while urgently needed, random donor platelets, intravenous immunoglobulin, and steroids. We report on a case of neonatal alloimmune thrombocytopenia due to an anti-HPA-1b antibody in the third pregnancy of a 31-year-old Caucasoid woman. The infant was treated with repeated maternal and random donor platelet transfusions and with a single dose of intravenous immunoglobulin.
Moosmann
P
P
Abteilung für Hämatologie, Transfusionsmedizin, Universitätsspital Zürich.
Fauchère
J C
JC
Halter
J
J
Binder
D
D
Schanz
U
U
D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017713:Platelet Transfusion; D011247:Pregnancy; D013921:Thrombocytopenia / Q000097:blood / Q000276:immunology* / Q000628:therapy; D044465:White People
D016824:Antigens, Human Platelet; D001323:Autoantibodies; D000939:Epitopes; C083451:human platelet antigen 1b