The prevention and treatment of vascular graft infection with a Triclosan (Irgasan)-bonded Dacron graft: an experimental study in the pig.
OBJECTIVE
to evaluate the role of Triclosan (Irgasan(R)) in the prevention of prosthetic graft infection.


METHODS
fifty-one pigs were assigned randomly to six groups. Group I (graft) and II (graft and Triclosan) were control groups. Groups III (graft) and IV (grafts and Triclosan) were contaminated with 2 x 10(7)CFU/ml S. aureus. Groups V (graft) and VI (graft and Triclosan) were intraoperatively contaminated with 2 x 10(7)CFU/ml S. aureus and reoperated on after 7 days. Remaining animals were sacrificed on day 28. The end point of the investigation was vascular graft infection, defined as the bacteriological and/or histological proof of infection. Results in both control groups no vascular graft infections were detected in Groups I and II. All of the group III animals presented but none of the group IV developed a graft infection (p <0.02). All of the group V animals presented and 10 of 12 animals developed a graft infection.


CONCLUSIONS
in this animal model Triclosan bonding appears effective in preventing prosthetic graft infection. However, the in situ replacement of Triclosan-protected grafts was not successful in the treatment of graft infection.
Hernandez-Richter
T
T
Chirurgische Klinik und Poliklinik, Klinikum Grosshadern, Ludwig Maximilians-Universität, München, Germany.
Schardey
H M
HM
Löhlein
F
F
Heiss
M M
MM
Redondo-Müller
M
M
Hammer
C
C
Schildberg
F W
FW
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001807:Blood Vessel Prosthesis; D004195:Disease Models, Animal; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000517:prevention & control; D011897:Random Allocation; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000517:prevention & control; D013552:Swine; D014260:Triclosan / Q000008:administration & dosage*
D000891:Anti-Infective Agents, Local; D011093:Polyethylene Terephthalates; D014260:Triclosan