Unilateral glaucoma in Sotos syndrome (cerebral gigantism).
OBJECTIVE
To report a patient with unilateral glaucoma associated with Sotos syndrome. Sotos syndrome (cerebral gigantism) is a disorder of growth and development with characteristic facial changes and normal endocrine function. Ocular manifestations may also include megalocornea, iris hypoplasia, cataracts, megalophthalmos, strabismus, nystagmus, and retinal dystrophy.


METHODS
Case report. A 50 year-old man with the clinical features of Sotos syndrome presented with complaints of decreased vision in the left eye.


RESULTS
Ophthalmologic examination revealed bilateral megalocornea, megalophthalmos, iris hypoplasia and transillumination defects, cataracts, and unilateral glaucoma. Intraocular pressure was lowered, and visual field loss was stabilized with topical medications.


CONCLUSIONS
Sotos syndrome patients should be examined routinely to allow for early detection and treatment of potential ocular problems, including glaucoma.
Yen
M T
MT
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA. dryen@prodigy.net
Gedde
S J
SJ
Flynn
J T
JT
D000015:Abnormalities, Multiple / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000002:abnormalities*; D002386:Cataract / Q000209:etiology; D003315:Cornea / Q000002:abnormalities / Q000473:pathology; D005124:Eye Abnormalities / Q000209:etiology* / Q000473:pathology; D005877:Gigantism / Q000150:complications*; D005901:Glaucoma / Q000209:etiology*; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000002:abnormalities / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014794:Visual Fields