title: Plasma beta-endorphin concentrations are increased in chronic obstructive pulmonary disease patients.
abstract: The present study is concerned with plasma beta-endorphin and glucose tolerance in patients with chronic obstructive pulmonary disease (COPD). Plasma beta-endorphin, glucagon and insulin concentrations were measured during an oral glucose tolerance test in 20 COPD patients and in 18 age-matched healthy controls (mean age 62 years). Seven patients had a moderate COPD (group I) and seven a severe COPD (group II). The remaining six severe COPD patients received long-term oxygen therapy (group III). We found that fasting levels of beta-endorphin were significantly increased in all patient groups compared to healthy controls (p < 0.01, 0.05 and 0.005, respectively). Six of the 13 severely diseased COPD patients had impaired glucose tolerance. Plasma beta-endorphin levels decreased significantly during OGTT in the COPD patients (p < 0.05). Fasting beta-endorphin levels were higher in patients with impaired glucose tolerance than in those patients with normal OGTT (42.0 pmol/L +/- 11.4 SD versus 34.8 +/- 10.2). However, this difference was not statistically significant. In conclusion, this study showed that beta-endorphin concentrations are increased in COPD patients whether or not they receive oxygen therapy.
authors: Division of Pulmonary Medicine and University Hospital of Tromsø, Norway. MEDAUH@rito.no
authors: A
authors: A
authors: Hjalmarsen
authors: M
authors: M
authors: Viitanen
authors: T
authors: T
authors: Jenssen
authors: R
authors: R
authors: Jorde
authors: O
authors: O
authors: Johansen
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D005934:Glucagon / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008297:Male; D008875:Middle Aged; D001615:beta-Endorphin / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D001615:beta-Endorphin; D005934:Glucagon