[Collapsing glomerulopathy and cytomegalovirus, what are the links?].
BACKGROUND
Collapsing glomerulopathy is a form of focal and segmental glomerulosclerosis which occurs preferentially in black people. It causes severe nephrotic syndrome and quickly progresses towards end-stage renal failure.


METHODS
We report the case of a 16-year-old black girl from Guadeloupe who was admitted for tetanus and edema in 1996. She had hypoparathyroidism, renal failure and a nephrotic syndrome as well as cytomegalovirus infection. Renal biopsy showed collapsing glomerulopathy. The renal function improved on glucocorticoid and ganciclovir therapy and her serum creatinine stabilized around 250 mumol/l for two years.


CONCLUSIONS
Collapsing nephropathy is the cellular type of focal and segmental glomerulosclerosis. The main etiology is the human immunodeficiency virus. A viral infection may be involved in its pathogenesis. Other viruses could be linked with this nephropathy. This case report relates a case associated with a cytomegalovirus viruria. The clinical course might be related with the antiviral treatment.
Presne
C
C
Service de Néphrologie, Groupe Hospitalier Sud, Amiens. clairepresne@club-internet.fr
Cordonnier
C
C
Makdassi
R
R
Pruna
A
A
Fournier
A
A
D016263:AIDS-Associated Nephropathy / Q000473:pathology*; D017088:AIDS-Related Opportunistic Infections / Q000473:pathology*; D000293:Adolescent; D001706:Biopsy; D044383:Black People; D003586:Cytomegalovirus Infections / Q000473:pathology*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology; D011379:Prognosis