Why Helicobacter pylori has Lewis antigens.
In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.
Appelmelk
B J
BJ
Dept of Medical Microbiology, Vrije Universiteit, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. bj.appelmelk.mm@med.vu.nl
Monteiro
M A
MA
Martin
S L
SL
Moran
A P
AP
Vandenbroucke-Grauls
C M
CM
D001422:Bacterial Adhesion / Q000502:physiology; D002240:Carbohydrate Sequence; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D019081:O Antigens / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D014774:Virulence
D007983:Lewis Blood Group Antigens; D019081:O Antigens