title: Nonparametric rank-based methods for group sequential monitoring of paired censored survival data.
abstract: This research gives methods for nonparametric sequential monitoring of paired censored survival data in the two-sample problem using paired weighted log-rank statistics with adjustments for dependence in survival and censoring outcomes. The joint asymptotic closed-form distribution of these sequentially monitored statistics has a dependent increments structure. Simulations validating operating characteristics of the proposed methods highlight power and size consequences of ignoring even mildly correlated data. A motivating example is presented via the Early Treatment Diabetic Retinopathy Study.
authors: Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109-2029, USA. skmurray@umich.edu
authors: S
authors: S
authors: Murray
mesh_terms: D001699:Biometry / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D015233:Models, Statistical; D009010:Monte Carlo Method; D018709:Statistics, Nonparametric; D016019:Survival Analysis