Augmentation with sulpiride for a schizophrenic patient partially responsive to clozapine.
OBJECTIVE
Schizophrenic patients who are only partially responsive to clozapine pose a therapeutic challenge. In these circumstances some clinicians would consider adding in a second antipsychotic. We present a case report and review evidence for the efficacy of such augmentation strategies.


METHODS
Single case report and literature review.


RESULTS
The total number of patients in studies and case reports of combining clozapine with other antipsychotics is small. There has been only one randomized controlled trial. This found the addition of sulpiride to clozapine resulted in clinical improvement in some patients.


CONCLUSIONS
Further randomized controlled studies of augmentation of clozapine therapy are needed to provide scientific justification for this clinical practice.
Stubbs
J H
JH
Department of Pharmacy, St Andrew's Hospital, Northampton, UK.
Haw
C M
CM
Staley
C J
CJ
Mountjoy
C Q
CQ
D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003024:Clozapine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D013469:Sulpiride / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D013469:Sulpiride; D003024:Clozapine