title: Allo-tolerance and allorejection responses ex vivo.
abstract: Spleen cells from fully immune competent mice show different intracellular STAT responses to alloantigen. Cells from mice primed to accept the alloantigen have low STAT 6 and fragmented STAT 4, compared to cells from mice primed to reject the same alloantigen.
authors: Department of Surgery, University of Cambridge, Addenbrookes Hospital, UK.
authors: S D
authors: SD
authors: Moffatt
authors: S
authors: S
authors: Metcalfe
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000502:physiology; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D007108:Immune Tolerance; D007519:Isoantigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008894:Milk Proteins; D050794:STAT1 Transcription Factor; D050797:STAT4 Transcription Factor; D050799:STAT5 Transcription Factor; D050800:STAT6 Transcription Factor; D016038:Skin Transplantation / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D015534:Trans-Activators / Q000502:physiology; D023001:Transplantation Tolerance; D014184:Transplantation, Homologous / Q000276:immunology
chemical_list: D004268:DNA-Binding Proteins; D007519:Isoantigens; D008894:Milk Proteins; D050794:STAT1 Transcription Factor; D050797:STAT4 Transcription Factor; D050799:STAT5 Transcription Factor; D050800:STAT6 Transcription Factor; C494080:Stat1 protein, mouse; C494091:Stat4 protein, mouse; C494100:Stat6 protein, mouse; D015534:Trans-Activators