title: Fractionated stereotactic radiotherapy for vestibular schwannoma (VS): comparison between cystic-type and solid-type VS.
abstract: OBJECTIVE
  To compare the effectiveness and complications of fractionated stereotactic radiotherapy (SRT) for cystic-type vestibular schwannoma (VS) with those of solid-type VS.
  
  
  METHODS
  In 65 patients treated with fractionated SRT between 1991 and 1999, 20 were diagnosed with cystic VS, in which at least one-third of the tumor volume was a cystic component on magnetic resonance imaging (MRI), and 45 were diagnosed with solid VS. Thirty-six Gy to 50 Gy in 20-25 fractions was administered to the isocenter and approximately 80% of the periphery of the tumor. All cystic and solid components were included in the gross tumor volume. The mean follow-up period was 37 months, ranging from 6 to 97 months.
  
  
  RESULTS
  The actuarial 3-year rate of no episode of enlargement greater than 2.0 mm was 55% for cystic-type and 75% for solid-type VS; the difference was statistically significant (p = 0.023). The actuarial 3-year tumor-reduction (reduction in tumor size greater than 2.0 mm) rates were 93% and 31%, respectively (p = 0.0006). The overall actuarial tumor control rate (no tumor growth greater than 2. 0 mm after 2 years or no requirement of salvage surgery) was 92% at 5 years in 44 patients with a follow-up period of 2 or more years. There was no difference in the class hearing preservation rate between cystic VS and solid VS. No permanent trigeminal or facial nerve palsy was observed in either group.
  
  
  CONCLUSIONS
  Transient tumor enlargement occurs in cystic VS more frequently than in solid-type VS, but the subsequent tumor-reduction rate in cystic VS is better.
authors: Department of Radiation Medicine, Hokkaido University School of Medicine, Sapporo, Japan. hshirato@radi.med.hokudai.ac.jp
authors: H
authors: H
authors: Shirato
authors: T
authors: T
authors: Sakamoto
authors: N
authors: N
authors: Takeichi
authors: H
authors: H
authors: Aoyama
authors: K
authors: K
authors: Suzuki
authors: K
authors: K
authors: Kagei
authors: T
authors: T
authors: Nishioka
authors: S
authors: S
authors: Fukuda
authors: Y
authors: Y
authors: Sawamura
authors: K
authors: K
authors: Miyasaka
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002150:Caloric Tests; D003560:Cysts / Q000601:surgery*; D003638:Deafness / Q000517:prevention & control; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*; D016896:Treatment Outcome