title: The pyoverdin receptor FpvA, a TonB-dependent receptor involved in iron uptake by Pseudomonas aeruginosa (review).
abstract: Iron is an important element, essential for the growth of almost all living cells. Because of the high insolubility of iron(III) in aerobic conditions, many gram-negative bacteria produce, under iron limitation, small iron-chelating compounds called siderophores, together with new outer-membrane proteins, which function as receptors for the ferrisiderophores. Pseudomonas aeruginosa, an important human opportunistic pathogen, produces at least three known siderophores when grown in iron-deficient conditions: pyochelin, salicylate and pyoverdin. This review focuses on pyoverdin and on the ability of FpvA to bind iron-free and ferric-PaA pyoverdin, in the light of recent information gained from biochemical and biophysical studies and of the recently solved 3D-structures of the related ferrichrome FhuA and enterobactin FepA receptors in Escherichia coli.
authors: Département des Récepteurs et Protéines Membranaires, UPR 9050 CNRS, Boulevard Sébastien Brant, F-67400 Illkirch, Strasbourg, France.
authors: N
authors: N
authors: Folschweiller
authors: I J
authors: IJ
authors: Schalk
authors: H
authors: H
authors: Celia
authors: B
authors: B
authors: Kieffer
authors: M A
authors: MA
authors: Abdallah
authors: F
authors: F
authors: Pattus
mesh_terms: D000595:Amino Acid Sequence; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry; D004926:Escherichia coli / Q000737:chemistry; D029968:Escherichia coli Proteins; D007501:Iron / Q000493:pharmacokinetics*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009842:Oligopeptides; D010860:Pigments, Biological / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D011956:Receptors, Cell Surface; D011991:Receptors, Virus / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D013053:Spectrophotometry
chemical_list: D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; C050900:FhuA protein, E coli; C082326:FpvA protein, Pseudomonas aeruginosa; D008565:Membrane Proteins; D009842:Oligopeptides; D010860:Pigments, Biological; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C029489:enterobactin receptor; C057616:tonB protein, Bacteria; C489181:tonB protein, E coli; C042453:pyoverdin; D007501:Iron