New multidrug resistance modulators from Atractylodis Lanceae Rhizoma.
Three new oligoacylated sucroses designated atractysucroses-I, -II, and -III were obtained from Atractylodis Lanceae Rhizoma as multidrug resistance (MDR) modulating substances against human carcinoma cell lines and their chemical structures were characterized as a mixture of acyl groups. Atractysucrose-I modulates MDR in KB-C2 cells as strongly as verapamil. This is the first example of an MDR-modulator classified as a carbohydrate.
Murakami
N
N
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Iwata
E
E
Tamura
S
S
Akiyama
S
S
Kobayashi
M
M
D019659:Asteraceae / Q000737:chemistry*; D018432:Drug Resistance, Multiple; D006801:Humans; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured