Methamphetamine and HIV-1: potential interactions and the use of the FIV/cat model.
The interaction of methamphetamine with human immunodeficiency virus (HIV), the aetiologic agent of Acquired Immune Deficiency Syndrome (AIDS), has not been thoroughly investigated. However, increasingly, a larger proportion of HIV infected individuals acquire the virus through methamphetamine use or are exposed to this drug during their disease course. In certain populations, there is a convergence of methamphetamine use and HIV-1 infection; yet our understanding of the potential effects that simultaneous exposure to these two agents have on disease progression is extremely limited. Studying the interactions between methamphetamine and lentivirus in people is difficult. To thoroughly understand methamphetamine's effects on lentivirus disease progression, an animal model that is both clinically relevant and easily manipulated is essential. In this report, we identified potential problems with methamphetamine abuse in individuals with a concurrent HIV-1 infection, described the Feline Immunodeficiency Virus (FIV)/cat model for HIV-1, and reported our early findings using this modelling system to study the interaction of methamphetamine and lentivirus infections.
Phillips
T R
TR
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA. tphillips@scripps.edu
Billaud
J N
JN
Henriksen
S J
SJ
D019969:Amphetamine-Related Disorders / Q000150:complications / Q000503:physiopathology*; D000818:Animals; D002415:Cats; D016181:Feline Acquired Immunodeficiency Syndrome / Q000150:complications / Q000503:physiopathology*; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology*; D015497:HIV-1; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects / Q000502:physiology*; D008694:Methamphetamine / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D008694:Methamphetamine