Darier's disease: a new paradigm for genetic studies in psychiatric disorders.
BACKGROUND
One strategy for identifying susceptibility genes for common disorders is to investigate Mendelian diseases, cosegregating with these common disease phenotypes.


METHODS
A family with seven members is described, in which three members present Darier's disease and depression. This apparent cosegregation, if true, would support the hypothesis that in some pedigrees, a gene for mood disorder may be located on chromosome 12.
Cordeiro
Q
Q
Institute of Psychiatry, School of Medicine, Universidade de São Paulo, São Paulo, Brazil.
Werebe
D M
DM
Vallada
H
H
D000328:Adult; D020090:Chromosome Segregation / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D007644:Darier Disease / Q000150:complications / Q000235:genetics* / Q000523:psychology; D003863:Depression / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000235:genetics; D010375:Pedigree