title: Gene expression of the insulin-like growth factor system during postnatal development of the rat pituitary gland.
abstract: Insulin-like growth factors I and II (IGFI and II) are synthesized by anterior pituitary cells and participate in cellular growth and differentiation, as well as the control of pituitary hormone secretion. Type 1 and 2 IGF receptors (IGFR1 and IGFR2) and the six IGF binding proteins (IGFBPs), which modulate IGF effects, are expressed in the anterior pituitary gland. We used in situ hybridization to analyse the temporal expression pattern of IGFI and II, IGFR1 and 2 and IGFBP1-6 in the anterior pituitary gland during postnatal development in both male and female rats (10, 20, 30, 40 and 60 days of age). We found all of the components of the IGF system to be expressed in the anterior pituitary gland, with each having a specific temporal pattern of expression. In addition, there exist differences between the sexes in the expression of some components of the IGF system. These data emphasize that in the anterior pituitary gland the IGF system is under tight regulation during postnatal life when this gland continues to develop. The distinct temporal expression of each member of the IGF system may indicate specific roles in the development and physiology of the anterior pituitary gland.
authors: Department of Paediatrics, Subdivision of Molecular Endocrinology, Erasmus University Rotterdam, The Netherlands.
authors: S
authors: S
authors: González-Parra
authors: J
authors: J
authors: Argente
authors: J A
authors: JA
authors: Chowen
authors: M
authors: M
authors: van Kleffens
authors: J W
authors: JW
authors: van Neck
authors: D J
authors: DJ
authors: Lindenbeigh-Kortleve
authors: S L
authors: SL
authors: Drop
mesh_terms: D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000254:growth & development* / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D017526:Receptor, IGF Type 1 / Q000235:genetics; D017527:Receptor, IGF Type 2 / Q000235:genetics; D012727:Sex Characteristics
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D012333:RNA, Messenger; D017527:Receptor, IGF Type 2; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1