Reactivation of hepatitis B virus replication accompanied by acute hepatitis in patients receiving highly active antiretroviral therapy.
We describe 2 patients who were initially positive for antibodies to hepatitis B surface antigen and who experienced a strong and sudden increase of hepatitis B virus (HBV) replication during highly active antiretroviral therapy (HAART). We found that reactivation of HBV replication during HAART can occur independently of lamivudine resistance or withdrawal of lamivudine, and in spite of increasing CD4(+) cell counts.
Manegold
C
C
Klinische Abteilung, Bernhard-Nocht-Institut für Tropenmedizin, Hamburg, Germany. manegold@bni.uni-hamburg.de
Hannoun
C
C
Wywiol
A
A
Dietrich
M
M
Polywka
S
S
Chiwakata
C B
CB
Günther
S
S
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D004279:DNA, Viral / Q000097:blood; D006509:Hepatitis B / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics / Q000254:growth & development*; D006801:Humans; D019259:Lamivudine / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008969:Molecular Sequence Data; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D014775:Virus Activation; D014779:Virus Replication
D019380:Anti-HIV Agents; D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine