title: Choosing a route of administration for quadrivalent meningococcal polysaccharide vaccine: intramuscular versus subcutaneous.
abstract: A clinical trial was conducted to compare intramuscular (im) with subcutaneous (sc) routes for administration of quadrivalent meningococcal polysaccharide vaccine in 141 adults. Safety assessment showed the im route had reduced erythema (P<.01) and reduced headache on days 1 and 2 (P<.05). Serological testing for serum bactericidal antibody titers against capsular groups A and C did not detect significant differences.
authors: Department of Scientific and Medical Affairs, Aventis Pasteur, Swiftwater, PA 18370-0187, USA. fred.ruben@aventis.com
authors: F L
authors: FL
authors: Ruben
authors: J E
authors: JE
authors: Froeschle
authors: C
authors: C
authors: Meschievitz
authors: K
authors: K
authors: Chen
authors: J
authors: J
authors: George
authors: M K
authors: MK
authors: Reeves-Hoché
authors: P
authors: P
authors: Pietrobon
authors: M
authors: M
authors: Bybel
authors: W C
authors: WC
authors: Livingood
authors: L
authors: L
authors: Woodhouse
mesh_terms: D000328:Adult; D003257:Consumer Product Safety; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008297:Male; D022401:Meningococcal Vaccines / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D022401:Meningococcal Vaccines