Fluvoxamine increases plasma and urinary levels of clozapine and its major metabolites in a time- and dose-dependent manner.
Fabrazzo
M
M
La Pia
S
S
Monteleone
P
P
Mennella
R
R
Esposito
G
G
Pinto
A
A
Maj
M
M
D000328:Adult; D000704:Analysis of Variance; D003024:Clozapine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D016666:Fluvoxamine / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics*
D003024:Clozapine; D016666:Fluvoxamine; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors