title: Elevation of neuron-specific enolase in serum and cerebrospinal fluid of early stage Creutzfeldt-Jakob disease.
abstract: OBJECTIVE
  To investigate the levels of neuron-specific enolase (NSE) in serum and cerebrospinal fluid (CSF) of patients with early stage Creutzfeldt-Jakob disease (CJD).
  
  
  METHODS
  The levels of NSE in serum and CSF were examined in 6 cases with CJD patients. The levels of NSE in CSF were measured in 8 age matched control patients with other neurological diseases and the levels of serum NSE were also measured in another 8 age matched control patients with other neurological diseases. The groups of 8 age matched control patients consisted of 1 same patient and 7 different patients in the 2 control groups both for serum and CSF.
  
  
  RESULTS
  The level of serum NSE in CJD (17.3 +/- 7.0 ng/ml, mean +/- SD) was significantly higher than that of controls (6.5 +/- 1.6) (P < 0.02) as was the case in CSF (79.3 +/- 53.3 ng/ml) vs (9.6 +/- 2.9) (P < 0.03).
  
  
  CONCLUSIONS
  Although mean NSE levels of CJD were higher in CSF than in the serum, there still is a case with higher serum NSE level than CSF. These results suggest that the mechanism of elevation of serum NSE may not be a simple leakage from CSF, and that the measurement of serum NSE level may be useful for diagnosis of early stage CJD.
authors: Department of Neurology, Okayama University Medical School. kohira@kcan.ne.jp
authors: I
authors: I
authors: Kohira
authors: T
authors: T
authors: Tsuji
authors: H
authors: H
authors: Ishizu
authors: Y
authors: Y
authors: Takao
authors: A
authors: A
authors: Wake
authors: K
authors: K
authors: Abe
authors: S
authors: S
authors: Kuroda
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D007562:Creutzfeldt-Jakob Syndrome / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood* / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D010751:Phosphopyruvate Hydratase