Connecting signaling and cell cycle progression in growth factor-stimulated cells.
A widely used model system to investigate cell proliferation is stimulation of serum-arrested cells with growth factors. Recent data suggest that there are two waves of growth factor-dependent signaling events required for a proliferative response. One is an acute burst of signaling, which occurs immediately after growth factor stimulation and lasts for 30 - 60 min. The other occurs in a different time frame (8 - 12 h post stimulation), and involves activation of cyclin dependent kinases (Cdks). In addition to a general overview of growth factor-dependent signaling, we present our 'two wave' hypothesis for how signaling and cell cycle progression are linked.
Jones
S M
SM
Schepens Eye Research Institute, 20 Staniford Street, Boston, Massachusetts, MA 02114, USA.
Kazlauskas
A
A
D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*
D010982:Platelet-Derived Growth Factor