Mechanisms of angiotensin II-induced platelet-derived growth factor gene expression.
Angiotensin II induces the expression of platelet-derived growth factor A-chain and B-chain in cultured vascular smooth muscle cells at the level of transcription. The renin-angiotensin system has also been implicated in the increased expression of platelet-derived growth factor in the mechanically-injured artery wall. This review is concerned with recent developments in our understanding of the signaling and transcriptional mechanisms mediating the inducible expression of one vasoconstrictor by another.
Khachigian
L M
LM
Centre for Thrombosis and Vascular Research, The University of New South Wales, Sydney, Australia.
Takuwa
Y
Y
Collins
T
T
D000804:Angiotensin II / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D010982:Platelet-Derived Growth Factor / Q000235:genetics*; D011945:Receptors, Angiotensin / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology; D014661:Vasoconstriction
D010982:Platelet-Derived Growth Factor; D011945:Receptors, Angiotensin; D000804:Angiotensin II