Methotrexate and the photodermatitis reactivation reaction: a case report and review of the literature.
Methotrexate is an antimitotic and immunosuppressive agent used for the treatment of cancer, psoriasis, and rheumatologic disorders and for the termination of ectopic pregnancies. Physicians advising patients on the use of methotrexate need to be aware of its possible side effects, including photosensitivity. We present a patient who received methotrexate for the termination of an ectopic pregnancy and experienced a severe reactivation of her sunburn. The literature was reviewed on the types of photosensitivity and their relationship to methotrexate.
Khan
A J
AJ
Department of Dermatology, State University of New York at Stony Brook, USA.
Marghoob
A A
AA
Prestia
A E
AE
Spector
I J
IJ
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D011184:Postoperative Period; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000601:surgery; D012008:Recurrence; D013997:Time Factors
D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate