High rate of tuberculosis reinfection during a nosocomial outbreak of multidrug-resistant tuberculosis caused by Mycobacterium bovis strain B.
We present a study of a nosocomial outbreak of multidrug-resistant tuberculosis caused by Mycobacterium bovis in 31 patients, 30 of whom were infected with human immunodeficiency virus; all 31 died of progressive tuberculosis. All M. bovis strains had identical spoligotyping patterns and showed resistance to 12 antituberculosis drugs. Reinfection was suggested in 11 cases and confirmed in 4 by molecular typing methods. The causative strain was named "B strain."
Rivero
A
A
Department of Infectious Diseases, Reina Sofía University Hospital of Córdoba, Córdoba, Spain. megasevilla@interbook.net
Márquez
M
M
Santos
J
J
Pinedo
A
A
Sánchez
M A
MA
Esteve
A
A
Samper
S
S
Martín
C
C
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D004196:Disease Outbreaks; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D010430:Pentosyltransferases / Q000235:genetics; D012008:Recurrence; D013030:Spain / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control
D000995:Antitubercular Agents; D010430:Pentosyltransferases; C101967:arabinosyltransferase