title: In vitro validation of a new approach for quantitating regurgitations using proximal isovelocity surface area.
abstract: The present work has been designed to validate the calculation of the effective regurgitant orifice (ERO) area with the use of a new formula that takes into account the velocity profile (V(r) vs r) and that is insensitive to errors in the determination of the position of the orifice. Assuming a hemispheric model, ERO = 2 pi r(2). V(r)/V(o) (with V(o) = velocity at the orifice) and (V(o)/V(r))(0.5) = (2 pi/ERO)(0.5) r. Thus, the slope of the corresponding linear regression allows ERO to be calculated as: ERO = 2 pi/slope(2). This approach was tested in vitro in pulsatile conditions on circular, conical, and slit-like orifices. The calculated ERO was compared with the actual jet cross sectional area derived from the transverse velocity profile at the jet origin. For the purpose of comparison, the "classical" ERO was calculated for all the configurations, angulations, and threshold velocities. The relationship between (V(o)/V(r))(0.5) was linear (r > 0.98) over a wide range of velocities. The nonhemispheric components were found to modify the constant and not the slope. The mean variation of the calculated ERO was 6.5%. The correlation between the calculated and the actual ERO was very close (>0.97) with slope equal to 0.96. By comparison with the new method, the classical formula gave an underestimation of the ERO that dramatically increased when studying the flow closer to the orifice or in the case of error on the measurement of r. In conclusion, a method using velocity profiles instead of isolated values improves the accuracy of the proximal isovelocity surface area (PISA) method for measuring the ERO.
authors: Unité INSERM 494 and Department of Cardiology, Broussais Hospital, Paris, France.
authors: A
authors: A
authors: Delouche
authors: M P
authors: MP
authors: Augusseau
authors: P
authors: P
authors: Dumée
authors: P
authors: P
authors: Delouche
authors: B
authors: B
authors: Diebold
mesh_terms: D001783:Blood Flow Velocity; D006801:Humans; D017078:Laser-Doppler Flowmetry; D016014:Linear Models; D008833:Microcirculation; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D018615:Ultrasonography, Doppler, Color