title: Phylogenetic relationships of human populations in sub-Saharan Africa.
abstract: This study utilizes the GM/KM immunoglobulin allotype system to elucidate the phylogenetic relationships of sub-Saharan Africans. The importance of understanding the relatedness of these peoples stems from the sub-Saharan region being the possible birthplace of humans. Haplotype distributions were determined for 19 populations and compared using chi-square analysis. Published data of other sub-Saharan Africans and representative populations worldwide were also added for comparison. Genetic distances between populations were calculated based on haplotype frequencies, and genetic relationships were observed through principal components analysis. Data from the GM/KM system showed a genetic homogeneity of the Bantu populations, with some exceptions, supporting the possibility of a common origin of these peoples. The Malagasy appeared as a divergent population, most likely due to Southeast Asian/Austronesian admixture, as indicated by the presence of the GM*AF B haplotype. The Cape Coloured also showed a divergence, with their genetic structures containing Caucasoid and Khoisan contributions. Finally, the Mbuti Pygmies appeared genetically isolated and had the highest frequency of the GM*A B haplotype out of all studied populations.
authors: University of Wisconsin-Platteville, 53818, USA.
authors: W
authors: W
authors: Weber
authors: D J
authors: DJ
authors: Nash
authors: A G
authors: AG
authors: Motulsky
authors: M
authors: M
authors: Henneberg
authors: M H
authors: MH
authors: Crawford
authors: S K
authors: SK
authors: Martin
authors: J M
authors: JM
authors: Goldsmid
authors: G
authors: G
authors: Spedini
authors: S
authors: S
authors: Glidewell
authors: M S
authors: MS
authors: Schanfield
mesh_terms: D017954:Africa South of the Sahara; D044383:Black People / Q000235:genetics*; D016009:Chi-Square Distribution; D005006:Ethnicity / Q000235:genetics; D005163:Factor Analysis, Statistical; D005787:Gene Frequency / Q000235:genetics*; D005788:Gene Pool; D014644:Genetic Variation / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D007131:Immunoglobulin Km Allotypes / Q000235:genetics*; D008037:Linguistics; D010641:Phenotype; D010802:Phylogeny
chemical_list: D007129:Immunoglobulin Gm Allotypes; D007131:Immunoglobulin Km Allotypes