A new synthesis of a key intermediate of beta-lactam antibiotics via diastereoselective alkylation of beta-hydroxy ester.
Ham
W H
WH
College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea. whham@speed.skku.ac.kr
Oh
C Y
CY
Lee
Y S
YS
Jeong
J H
JH
D000478:Alkylation; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D004952:Esters; D006885:Hydroxybutyrates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D004952:Esters; D006885:Hydroxybutyrates; D047090:beta-Lactams