[Cisapride does not modify prolonged Q-T interval in patients with liver cirrhosis].
BACKGROUND
Abnormal small bowel motility, observed in liver cirrhosis, can be reversed with cisapride. Since both cisapride and liver disease are associated with prolonged QT interval, the possibility of adverse cardiovascular effects might be expected with cisapride treatment in these patients.


OBJECTIVE
To evaluate QT interval and other electrocardiographic changes during long term treatment with cisapride in cirrhotic patients.


METHODS
Forty seven cirrhotic patients were studied. Electrocardiogram was recorded and the QT interval corrected according to Bazzett's formula was determined (normal value < 0.44 s). Seventeen patients were treated with cisapride, 10 mg tid for seven months and electrocardiographic controls were performed at the end of the treatment.


RESULTS
The mean corrected QT interval was 0.46 +/- 0.03 s (range 0.4-0.53). 34 patients (64%) had QTc prolongation (0.47 +/- 0.02 s). Statistically significant higher values of QTc were observed in patients at Child Pugh stage B and C compared to stage A. No statistically significant difference according to the etiology of liver disease, were observed. No changes in mean QTc duration were observed during cisapride treatment.


CONCLUSIONS
In spite that a prolonged QTc was a frequent finding in our series of selected patients, no cardiovascular adverse effects were observed with long term cisapride treatment.
Quera
R
R
Servicio de Gastroenterología y Centro Cardiovascular, Hospital Clínico de la Universidad de Chile.
Madrid
A M
AM
Ugalde
H
H
Defilippi
C
C
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D020117:Cisapride / Q000494:pharmacology* / Q000627:therapeutic use; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013599:Systole / Q000187:drug effects; D013997:Time Factors
D005765:Gastrointestinal Agents; D020117:Cisapride