Helper T cells in antibody-mediated, organ-specific autoimmunity.
The production of pathogenic autoantibodies in organ-specific autoimmune diseases is largely T cell dependent. For many of these diseases, the precise specificities and cytokine profiles of the T cells that respond to the corresponding autoantigens have now been identified. This knowledge has been exploited to treat some models of antibody-mediated autoimmunity using peptides corresponding to the dominant helper epitopes, giving impetus to the development of a similar approach in the equivalent human diseases.
Elson
C J
CJ
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. c.j.elson@bris.ac.uk
Barker
R N
RN
D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology; D000818:Animals; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D009157:Myasthenia Gravis / Q000276:immunology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D001323:Autoantibodies