FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties.
FR901469 is a novel antifungal antibiotic produced by an unidentified fungus No.11243. This compound was isolated from the culture broth by solvent extraction, HP-20 and YMC ODS gel column chromatography, and lyophilization. FR901469 is a white powder which melts at 182 approximately 187 degrees C and possesses the molecular formula C71H116N14O23. This compound has good water solubility. FR901469 inhibited the activity of 1,3-beta-glucan synthase from Candida albicans with an IC50 value of 0.05 microg/ml, and displayed greater inhibitory activity than other 1,3-beta-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B.
Fujie
A
A
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.
Iwamoto
T
T
Muramatsu
H
H
Okudaira
T
T
Nitta
K
K
Nakanishi
T
T
Sakamoto
K
K
Hori
Y
Y
Hino
M
M
Hashimoto
S
S
Okuhara
M
M
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects / Q000201:enzymology; D047630:Depsipeptides; D005260:Female; D005285:Fermentation; D005658:Fungi / Q000737:chemistry* / Q000378:metabolism; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055666:Lipopeptides
D000935:Antifungal Agents; D047630:Depsipeptides; D005964:Glucosyltransferases; D010456:Peptides, Cyclic; C417112:FR 901469; D055666:Lipopeptides; C040232:glucan synthase