title: Enhanced systolic function of the right ventricle during respiratory distress syndrome in newborn lambs.
abstract: Respiratory distress syndrome (RDS) causes pulmonary hypertension. It is often suggested that this increased afterload for the right ventricle (RV) might lead to cardiac dysfunction. To examine this, we studied biventricular function in an experimental model. RDS was induced by lung lavages in seven newborn lambs. Five additional lambs served as controls. Cardiac function was quantified by indexes derived from end-systolic pressure-volume relations obtained by pressure-conductance catheters. After lung lavages, a twofold increase of mean pulmonary arterial pressure (from 15 to 34 mmHg) was obtained and lasted for the full 4-h study period. Stroke volume was maintained (5.2 +/- 0.6 ml at baseline and 6.1 +/- 1.4 ml at 4 h of RDS), while RV end-diastolic volume showed only a slight increase (from 6.5 +/- 2.3 ml at baseline to 7.7 +/- 1.3 ml at 4 h RDS). RV systolic function improved significantly, as indicated by a leftward shift and increased slope of the end-systolic pressure-volume relation. Left ventricular systolic function showed no changes. In control animals, pulmonary arterial pressure did not increase and right and left ventricular systolic function remained unaffected. In the face of increased RV afterload, the newborn heart is able to maintain cardiac output, primarily by improving systolic RV function through homeometric autoregulation.
authors: Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
authors: M
authors: M
authors: De Vroomen
authors: P
authors: P
authors: Steendijk
authors: R H
authors: RH
authors: Lopes Cardozo
authors: H H
authors: HH
authors: Brouwers
authors: F
authors: F
authors: Van Bel
authors: J
authors: J
authors: Baan
mesh_terms: D000465:Algorithms; D000818:Animals; D000831:Animals, Newborn; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002138:Calibration; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology; D007231:Infant, Newborn; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications / Q000503:physiopathology*; D012756:Sheep; D013599:Systole; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right