Response by B cell precursors to pre-B receptor assembly: differences between fetal liver and bone marrow.
The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a longstanding puzzle in immunology. In the past few years it has become clear that production of mu heavy chain and subsequent assembly with surrogate light chain to form the pre-B cell receptor complex is critical to promote development of adult B cell precursors in mouse bone marrow. Recently we found that instead of promoting pre-B cell expansion as in adult bone marrow, this complex inhibits pre-B cell growth in fetal liver, providing a previously unrecognized mechanism for alteration of the B cell repertoire with age. The consequence is very distinct primary repertoires for development of fetal B1 cells and adult bone marrow B2 cells.
Hardy
R R
RR
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. rr_hardy@fccc.edu
Wasserman
R
R
Li
Y S
YS
Shinton
S A
SA
Hayakawa
K
K
D000328:Adult; D000818:Animals; D000918:Antibody Specificity / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology*; D019070:Cell Lineage; D015322:Gene Rearrangement, B-Lymphocyte; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D005803:Genes, Immunoglobulin; D006411:Hematopoiesis, Extramedullary / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000196:embryology / Q000254:growth & development*; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D008099:Liver / Q000166:cytology / Q000196:embryology* / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000276:immunology*; D011993:Recombinant Fusion Proteins / Q000276:immunology; D014162:Transfection
D007135:Immunoglobulin Variable Region; D007148:Immunoglobulin mu-Chains; D011947:Receptors, Antigen, B-Cell; D011993:Recombinant Fusion Proteins