title: Protection of cattle against rinderpest by intranasal immunisation with a dry powder tissue culture vaccine.
abstract: Dry powder tissue culture rinderpest vaccine containing 10(2.5) TCID(50) of virus per dose administered intranasally to cattle induced high titre circulating antibody responses and protection against challenge with a virulent strain of rinderpest virus. A reduction in the dose of virus to 10(1.1) TCID(50) resulted in a failure to elicit detectable antibody responses and a lack of protection. Intranasal powder vaccine offers several advantages over conventional needle-administered aqueous rinderpest vaccine, including greater stability in the absence of a cold chain, reduced risk of 'needle transfer' of other microbial agents present in the vaccinated herd and lower cost.
authors: Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, Woking, UK.
authors: J
authors: J
authors: Anderson
authors: E
authors: E
authors: Fishbourne
authors: A
authors: A
authors: Corteyn
authors: A I
authors: AI
authors: Donaldson
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000302:isolation & purification; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D046508:Culture Techniques; D011208:Powders; D012301:Rinderpest / Q000276:immunology / Q000517:prevention & control*; D012302:Rinderpest virus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D014613:Vaccines, Attenuated / Q000008:administration & dosage; D014765:Viral Vaccines / Q000008:administration & dosage*; D014774:Virulence
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D011208:Powders; D014613:Vaccines, Attenuated; D014765:Viral Vaccines