The effect of anticonvulsant drugs on blood levels of methotrexate.
The reduced bioavailability of chemotherapeutic agents is one of the reasons that explains the limited efficacy of adjuvant chemotherapy in high grade glioma patients. We report how even the results of high dose sequential chemotherapy can be influenced by antiepileptic drugs.
Riva
M
M
Department of Neurology, Niguarda Cà-Granda Hospital, Milan, Italy. mauriva@tiscalinet.it
Landonio
G
G
Defanti
C A
CA
Siena
S
S
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001682:Biological Availability; D001932:Brain Neoplasms / Q000097:blood / Q000188:drug therapy*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004347:Drug Interactions; D005260:Female; D005910:Glioma / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008727:Methotrexate / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use
D000927:Anticonvulsants; D003577:Cytochrome P-450 Enzyme System; D002955:Leucovorin; D008727:Methotrexate