Beta-hydroxy-beta-methylbutyrate ingestion, part II: effects on hematology, hepatic and renal function.
OBJECTIVE
The purpose of this investigation was to examine the effects of differing amounts of beta-hydroxy-beta-methylbutyrate (HMB), 0, 36, and 76 mg x kg(-1) x d(-1), on hematology, hepatic and renal function during 8 wk of resistance training.


METHODS
Thirty-seven, untrained collegiate males and were randomly assigned to one of the three groups, 0, 38, or 76 mg x kg(-1) x d(-1). Resistance training consisted of 10 exercises, performed 3 d x wk(-1) for 8 wk at 80% of their 1-repetition maximum. Blood and urine was obtained before training, 48 h after the initial session, 1 wk, 2 wk, 4 wk, and at 8 wk of resistance training. Blood was analyzed for glucose, blood urea nitrogen, hemoglobin, hepatic enzymes, lipid profile, total leukocytes, and individual leukocytes. Urine was analyzed for pH, glucose, and protein excretion.


RESULTS
The 38 mg x kg(-1) x d(-1) group had a greater increase in basophils compared with 0 or 76 mg x kg(-1) x d(-1) groups (P < 0.05). No difference occurred in any other blood and urine measurements.


CONCLUSIONS
These data indicate that 8 wk of HMB supplementation (< or = 76 mg x kg(-1) x d(-1)) during resistance training had no adverse affects on hepatic enzyme function, lipid profile, renal function, or the immune system.
Gallagher
P M
PM
Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA.
Carrithers
J A
JA
Godard
M P
MP
Schulze
K E
KE
Trappe
S W
SW
D000293:Adolescent; D000328:Adult; D001774:Blood Chemical Analysis; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D014631:Valerates / Q000494:pharmacology*
D008055:Lipids; D014631:Valerates; C004961:beta-hydroxyisovaleric acid