Is it necessary to administer anti-D to prevent RhD immunization after the transfusion of RhD-positive platelet concentrates?
Serology for the presence of anti-D after RhD-incompatible platelet transfusions was performed in 24 RhD-negative patients with haematological disease and 59 RhD-negative patients with non-haematological disease. None of the patients were given prophylaxis with anti-D to prevent RhD immunization. Eight out of 59 (13.5%) non-haematology patients developed detectable anti-D, whereas 0 out of 24 (0%) of the haematology patients formed anti-D (P = 0.06). The risk of alloimmunization after RhD-incompatible platelet transfusions using platelet concentrates prepared by modern technical methods appears to be small in patients with haematological disease, but is significant in non-immunocompromised patients.
Atoyebi
W
W
Department of Haematology, John Radcliffe Hospital, Oxford, UK.
Mundy
N
N
Croxton
T
T
Littlewood
T J
TJ
Murphy
M F
MF
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000097:blood / Q000276:immunology / Q000601:surgery; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000276:immunology / Q000601:surgery; D006402:Hematologic Diseases / Q000097:blood / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D017713:Platelet Transfusion / Q000009:adverse effects*; D012189:Retrospective Studies; D012203:Rh Isoimmunization / Q000517:prevention & control*; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin / Q000627:therapeutic use*
D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin