Regional cerebral blood flow changes in drug-resistant depressed patients following treatment with transcranial magnetic stimulation: a statistical parametric mapping analysis.
Changes of regional cerebral blood flow (rCBF) in five drug-resistant depressed patients were examined by single photon emission computed tomography (SPECT) with 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) before and after treatment with transcranial magnetic stimulation (TMS). The SPECT images were analysed with the Statistical Parametric Mapping (SPM) package. TMS administered in the region of the left dorsolateral prefrontal cortex (DLPFC) of the depressed patients was associated with an increase of rCBF at a focal region some distance from the stimulation site. No change was observed at any other remote region.
Zheng
X M
XM
School of Clinical Sciences, Faculty of Health Studies, Charles Sturt University, Locked Bag 588, NSW 2678, Wagga Wagga, Australia. xzheng@csu.edu.au
D000928:Antidepressive Agents / Q000627:therapeutic use; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D004351:Drug Resistance; D055590:Electromagnetic Phenomena / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000098:blood supply* / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D000928:Antidepressive Agents; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime