[Effect of the cholinesterase reactivator dipyroxime in various models of delayed hypersensitivity during acute intoxication by acrylonitrile].
Delayed type hypersensitivity (DTH) response with respect to sheep erythrocytes was studied on various models in CBA mice against the background of acute intoxication with nitrile acrylic acid (NAA). The effect of dipiroxime on the DTH response under these conditions was determined and the relationship of these reactions with the activity of alpha-naphthylbutyratesterase in splenic cells and popliteal lymph nodes was assessed. Dipiroxime partly recovered DTH in various experimental series (except for the reaction of suppressor cell transfer) by restoring the alpha-naphthylbutyratesterase activity in cells of the lymphoid organs studied.
Zabrodskiĭ
P F
PF
Toxicology Department, Saratov State Medical University, Russia.
Kirichuk
V F
VF
Romashchenko
S A
SA
Germanchuk
V G
VG
D000181:Acrylonitrile / Q000506:poisoning*; D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000201:enzymology / Q000276:immunology*; D007928:Lethal Dose 50; D008198:Lymph Nodes / Q000201:enzymology; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep; D013154:Spleen / Q000201:enzymology; D014289:Trimedoxime / Q000494:pharmacology*
D000931:Antidotes; D002801:Cholinesterase Reactivators; D014289:Trimedoxime; D002265:Carboxylic Ester Hydrolases; C021855:naphthylbutyrate esterase; D000181:Acrylonitrile