Importance of microembolization and inflammation in atherosclerotic heart disease.
Considerable evidence now exists that inflammation is a central component of events that initiate and propagate an acute coronary syndrome. This process evokes the potential for embolization, which occurs more often than previously suspected, and imparts poor cardiovascular prognosis. Recent development of techniques to detect inflammation and embolization represents an important advance. In addition, therapies that diminish occurrence of these phenomena such as aspirin, statins, angiotensin converting enzyme (ACE) inhibitors, and IIb/IIIa receptor antagonists have been shown to improve outlook.
Yamada
D M
DM
Department of Cardiology, The Cleveland Clinic Foundation, OH 44195, USA.
Topol
E J
EJ
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology* / Q000473:pathology; D003328:Coronary Thrombosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000150:complications / Q000473:pathology; D015850:Interleukin-6 / Q000097:blood; D011379:Prognosis; D012720:Severity of Illness Index; D013923:Thromboembolism / Q000097:blood / Q000150:complications* / Q000473:pathology; D014336:Troponin / Q000097:blood
D015415:Biomarkers; D015850:Interleukin-6; D014336:Troponin; D002097:C-Reactive Protein