Latent Mycobacterium tuberculosis-persistence, patience, and winning by waiting.
Mycobacterium tuberculosis is a globally successful pathogen due to its ability to persist for long periods of time unrecognized by the human immune system. The panoply of genes that allows the organism to enter latency and then re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to suceed against tuberculosis.
Manabe
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YC
Johns Hopkins University, Departments of Medicine and International Health, Baltimore, Maryland 21205, USA. ymanabe@jhmi.eduwbishai@jhsph.edu
Bishai
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WR
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000220:Adaptation, Biological; D000818:Animals; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000276:immunology*