title: Effect of ration and exercise on plasma creatine kinase activity and lactate concentration in Thoroughbred horses with recurrent exertional rhabdomyolysis.
abstract: OBJECTIVE
  To determine the effects of 3 rations (low grain, fat, high grain) on plasma creatine kinase (CK) activity and lactate concentration in Thoroughbred horses with recurrent exertional rhabdomyolysis (RER).
  
  
  METHODS
  5 Thoroughbreds with RER and 3 healthy Thoroughbreds (control horses).
  
  
  METHODS
  Rations were formulated to meet (low-grain and fat rations) or exceed (high-grain ration) daily energy requirements. Each ration was fed to horses in a crossover design for 3 weeks. Horses were exercised on a treadmill Monday through Friday; maximum speed on Monday and Friday was 11 m/s (6% slope), on Tuesday and Thursday was 9 m/s, and on Wednesday was 4.5 m/s. Plasma CK activity and lactate concentration were determined before and after exercise.
  
  
  RESULTS
  Horses with RER fed the high-grain ration had significantly greater CK activity and change in CK activity 4 hours after exercise, compared with those fed the low-grain ration. Horses with RER exercised at the trot or canter had significantly greater increases in CK activity, compared with those exercised at the gallop. Plasma lactate concentrations after exercise were similar in control and affected horses. Lactate concentration and CK activity were not correlated in horses with RER.
  
  
  CONCLUSIONS
  Rations high in grain and formulated to exceed daily energy requirements may increase episodes of rhabdomyolysis in thoroughbred horses susceptible to RER.
authors: Department of Clinical and Population Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
authors: J M
authors: JM
authors: MacLeay
authors: S J
authors: SJ
authors: Valberg
authors: J D
authors: JD
authors: Pagan
authors: J L
authors: JL
authors: Xue
authors: F D
authors: FD
authors: De La Corte
authors: J
authors: J
authors: Roberts
mesh_terms: D000821:Animal Feed; D000818:Animals; D016022:Case-Control Studies; D003402:Creatine Kinase / Q000097:blood*; D018592:Cross-Over Studies; D002149:Energy Intake; D005260:Female; D005684:Gait; D006734:Horse Diseases / Q000097:blood / Q000503:physiopathology*; D006736:Horses; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D010805:Physical Conditioning, Animal; D012008:Recurrence; D012206:Rhabdomyolysis / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D019344:Lactic Acid; D003402:Creatine Kinase