title: Clinicopathologic analysis of stage II-III hepatocellular carcinoma showing early massive recurrence after liver resection.
abstract: OBJECTIVE
  Prognosis after hepatectomy for hepatocellular carcinoma (HCC) has been improved by progress in the evaluation of hepatic functional reserve, surgical techniques and perioperative management. However, even when curative resection is performed at a relatively early stage, a considerable number of patients develop early intrahepatic and/or extrahepatic recurrence postoperatively. This study analyzed the clinicopathologic features of HCC with early recurrence.
  
  
  METHODS
  We reviewed records of 513 consecutive patients who had undergone liver resection for HCC. There were 48 deaths within a year after surgery from recurrence, including 21 patients with stage II or III HCC (group I). Clinicopathologic parameters of group I patients were compared with those of 188 patients (group II) who developed recurrence following resection of stage II or III HCC and died more than 1 year after surgery.
  
  
  RESULTS
  On univariate analysis, age, tumor diameter (phi), alpha-fetoprotein (AFP):phi and protein induced by vitamin K absence or antagonist II (PIVKA-II):phi were significantly greater in group I than in group II. Macroscopic portal vein invasion, microscopic vascular invasion, intrahepatic metastasis, poor differentiation, pleomorphism, sarcomatous change, vascular lake, and angiographic condensed pooling were more frequently observed in group I than group II. Five independent determinants were selected by multivariate analysis: AFP:phi, histologic pleomorphism, sarcomatous change, vascular lake and angiographic condensed pooling.
  
  
  CONCLUSIONS
  Highly malignant HCC with extremely poor prognosis exhibits peculiar clinicopathologic characteristics, particularly histologic immaturity, and can be predicted by preoperative indicators such as markedly elevated tumor marker concentrations and condensed pooling on angiography.
authors: First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan. sjyamana@hyo-med.ac.jp
authors: J
authors: J
authors: Yamanaka
authors: N
authors: N
authors: Yamanaka
authors: K
authors: K
authors: Nakasho
authors: T
authors: T
authors: Tanaka
authors: T
authors: T
authors: Ando
authors: C
authors: C
authors: Yasui
authors: N
authors: N
authors: Kuroda
authors: M
authors: M
authors: Takata
authors: S
authors: S
authors: Maeda
authors: K
authors: K
authors: Matsushita
authors: K
authors: K
authors: Uematsu
authors: E
authors: E
authors: Okamoto
mesh_terms: D000368:Aged; D000792:Angiography; D015415:Biomarkers; D014408:Biomarkers, Tumor; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D011498:Protein Precursors / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin