Homozygous factor V Leiden mutation in a woman with multiple adverse pregnancy outcomes.
We report a case with one intrauterine fetal death (IUFD) at 32 weeks of gestation, one premature delivery at the same week, and one abortion of unknown etiology at 12 weeks of gestation. We discuss that the presence of homozygosity for Factor V Leiden may be associated with placental insufficiency in this woman. Application of anticoagulant therapy may have been beneficial in her current pregnancy.
Pauer
H U
HU
Department of Gynecology and Obstetrics, University of Goettingen, Germany.
Neesen
J
J
Schloesser
M
M
Hinney
B
B
Rauskolb
R
R
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D020147:Coagulation Protein Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D005165:Factor V / Q000235:genetics*; D005260:Female; D006720:Homozygote; D006801:Humans; D017354:Point Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000188:drug therapy
D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V