title: Phosphodiesterase inhibitors, pentoxifylline and rolipram, increase bone mass mainly by promoting bone formation in normal mice.
abstract: The administration of either Pentoxifylline (PTX), a methylxanthine derivative and an inhibitor of cyclic AMP (c-AMP) phosphodiesterases (PDEs), or Rolipram, an inhibitor specific to type-4 PDE (PDE4) in normal mice, significantly increased both cortical and cancellous bone mass. Vertebrae and tibiae from mice treated with PTX or Rolipram were analyzed by means of bone densitometry and histomorphometry. The results revealed that both PTX and Rolipram increased bone mass in normal mice mainly through the acceleration of bone formation. These findings suggest that both PTX and Rolipram can enhance physiological bone formation and thereby increase bone mass in normal mice. The possibility that these agents may be of value for the treatment of osteoporosis is discussed.
authors: Department of Orthopaedic Surgery, Shinshu University School of Medicine, Nagano, Japan.
authors: T
authors: T
authors: Kinoshita
authors: S
authors: S
authors: Kobayashi
authors: S
authors: S
authors: Ebara
authors: Y
authors: Y
authors: Yoshimura
authors: H
authors: H
authors: Horiuchi
authors: T
authors: T
authors: Tsutsumimoto
authors: S
authors: S
authors: Wakabayashi
authors: K
authors: K
authors: Takaoka
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D005269:Femur / Q000166:cytology / Q000000981:diagnostic imaging / Q000502:physiology; D008159:Lumbar Vertebrae / Q000166:cytology / Q000000981:diagnostic imaging / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010281:Parathyroid Hormone / Q000097:blood; D010431:Pentoxifylline / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D020889:Rolipram / Q000494:pharmacology*; D013977:Tibia / Q000166:cytology / Q000000981:diagnostic imaging / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D010726:Phosphodiesterase Inhibitors; D020889:Rolipram; D010431:Pentoxifylline