Applied genomics: integration of the technology within pharmaceutical research and development.
Multiple novel technologies have recently been developed to improve the analysis of genetic sequences, to rapidly assess RNA or protein levels in relevant tissues, and to validate function of potential new drug targets. The challenge facing pharmaceutical research is one of effective integration of these new technologies in ways that can maximally affect the discovery and development pipeline. Although database mining and transcriptional profiling clearly have increased the number of putative targets, the current focus is to assign function to new gene targets in a high-throughput manner. This requires a restructuring of the classical linear progression from gene identification, functional elucidation, target validation and screen development. New approaches are called for that can make this process non-linear and high-throughput.
Cockett
M
M
Applied Genomics, Bristol-Myers Squibb, 311 Pennington-Rocky Hill Road, Pennington, NJ 08534, USA.
Dracopoli
N
N
Sigal
E
E
D000818:Animals; D001709:Biotechnology; D016678:Genome; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D013678:Technology, Pharmaceutical