The carboxamide feG(NH2) inhibits endotoxin perturbation of intestinal motility.
The submandibular gland rat-1 (SMR1) salivary gland prohormone contains several peptides, submandibular gland peptide-T (SGP-T) and the tripeptide, FEG, which possess anti-inflammatory activities. The D-isomeric form of FEG, feG, also is a potent anti-inflammatory peptide. In this study, we compared the inhibitory activity of feG and its carboxamide derivative, feG(NH2), on the perturbations of intestinal motility induced by intravenous lipopolysaccharide. feG(NH2) was 20-30 times more potent than feG in reducing the motility disturbances induced by lipopolysaccharide. feG may undergo square-amidation to yield a hormone that strongly down-regulates intestinal responsiveness to endotoxin.
Tan
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Department of Pediatrics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Rougeot
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C
Davison
J S
JS
Mathison
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R
D000577:Amides; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000633:toxicity*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism
D000577:Amides; D004731:Endotoxins; D008070:Lipopolysaccharides; D009842:Oligopeptides; C114891:tripeptide FEG