Inhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle.
Growth and differentiation of postnatal hair follicles are controlled by reciprocal interactions between the dermal papilla and the surrounding epidermal hair precursors. The molecular nature of these interactions is largely unknown, but they are likely to involve several families of signaling molecules, including Fgfs, Wnts and Bmps. To analyze the function of Bmp signaling in postnatal hair development, we have generated transgenic mice expressing the Bmp inhibitor, Noggin, under the control of the proximal Msx2 promoter, which drives expression in proliferating hair matrix cells and differentiating hair precursor cells. Differentiation of the hair shaft but not the inner root sheath is severely impaired in Msx2-Noggin transgenic mice. In addition to hair keratins, the expression of several transcription factors implicated in hair development, including Foxn1 and Hoxc13, is severely reduced in the transgenic hair follicles. Proliferating cells, which are normally restricted to the hair matrix surrounding the dermal papilla, are found in the precortex and hair shaft region. These results identify Bmps as key regulators of the genetic program controlling hair shaft differentiation in postnatal hair follicles.
Kulessa
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Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Turk
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Hogan
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D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D002352:Carrier Proteins; D002454:Cell Differentiation; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics; D018859:Hair Follicle / Q000166:cytology / Q000254:growth & development*; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D007438:Introns; D007633:Keratins / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D011817:Rabbits; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics; D001616:beta-Galactosidase / Q000235:genetics; D000099176:Noggin Protein
D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D005914:Globins; D018398:Homeodomain Proteins; D007633:Keratins; D011506:Proteins; D014157:Transcription Factors; D001616:beta-Galactosidase; D000099176:Noggin Protein; C485834:Hoxc13 protein, mouse; C084119:MSX2 protein