title: Retrospective study of porcine circovirus 2 infection in Japan: seven cases in 1989.
abstract: Retrospectively, we demonstrated that seven pigs necropsied in 1989 had characteristic porcine circovirus 2 (PCV-2) lymphoid tissue lesions of severe lymphoid depletion, syncytial giant cell formation, and intracytoplasmic inclusion bodies in macrophages. Immunohistochemically, PCV-2 antigen was detected in these tissues and the distribution of positive staining corresponded to the distribution of inclusion bodies. Electron microscopy demonstrated viral particles compatible with porcine PCV-2. Therefore, the disease occurred in Japan as early as 1989.
authors: Hokusei Livestock Hygiene Service Center, Yokkaichi, Mie, Japan.
authors: M
authors: M
authors: Mori
authors: K
authors: K
authors: Sato
authors: S
authors: S
authors: Akachi
authors: S
authors: S
authors: Asahi
authors: S
authors: S
authors: Taniguchi
authors: M
authors: M
authors: Narita
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D018173:Circoviridae Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D017925:Circovirus / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D007150:Immunohistochemistry / Q000662:veterinary; D007564:Japan / Q000453:epidemiology; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008854:Microscopy, Electron / Q000662:veterinary; D014066:Palatine Tonsil / Q000473:pathology / Q000821:virology; D012189:Retrospective Studies; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000473:pathology / Q000821:virology*
chemical_list: D000956:Antigens, Viral