Searching for the polycystic ovary syndrome genes.
PCOS is a common disorder of unknown etiology. Studies of first-degree relatives of women diagnosed with PCOS suggest familial clustering of the disease. A prospective study of first-degree female relatives of women with PCOS conducted by NCPIR found that 46% of ascertainable sisters of women with PCOS were hyperandrogenemic. NCPIR has conducted linkage and association studies using affected sibling-pair analysis and the transmission/disequilibrium test to explore candidate PCOS genes. These studies point a finger at a region 1 MB centromeric to the insulin receptor gene on chromosome 19.
Urbanek
M
M
National Cooperative Program in Infertility Research, Department of Genetics, University of Pennsylvania, Philadelphia, USA.
Legro
R S
RS
Driscoll
D
D
Strauss
J F
JF
Dunaif
A
A
Spielman
R S
RS
D005260:Female; D008040:Genetic Linkage; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*