Two-component systems in Pseudomonas aeruginosa: why so many?
Screening the Pseudomonas aeruginosa genome has led to the identification of the highest number of putative genes encoding two-component regulatory systems of all bacterial genomes sequenced to date (64 and 63 encoding response regulators and histidine kinases, respectively). Sixteen atypical kinases, among them 11 devoid of an Hpt domain, and three independent Hpt modules were retrieved. These data suggest that P. aeruginosa possesses complex control strategies with which to respond to environmental challenges.
Rodrigue
A
A
Laboratoire d'Ingiénérie des Systemes Macromoléculaires, Centre National de la Recherche Scientifique, Marseille, France.
Quentin
Y
Y
Lazdunski
A
A
Méjean
V
V
Foglino
M
M
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D000071677:Histidine Kinase; D006801:Humans; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000235:genetics* / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction
D001426:Bacterial Proteins; D011494:Protein Kinases; D000071677:Histidine Kinase