Antiinflammatory activity of extracts and fractions from the leaves of Gochnatia polymorpha.
The aqueous and ethanol extracts from the leaves of Gochnatia polymorpha and further fractions obtained from the latter extract using solvents with increasing polarity, including its aqueous residue and the amino acid, 4-hydroxy-N-methyl-proline were investigated by carrageenin-induced pedal oedema formation. It was shown that the aqueous and ethanol extracts and the ethyl acetate fraction demonstrated significant antiinflammatory activity. The chemical investigation of the latter fraction revealed the presence of caffeic acid, chlorogenic acid, 3-0-methylquercetin, hyperosid and rutin. The amino acid 4-hydroxy-N-methyl-proline, a nonprotein amino acid that has not been reported before in the Asteraceae was isolated as a major compound and identified by spectroscopic methods.
Moreira
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AS
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul Av. Ipiranga 2752, 90610-000 Porto Alegre, RS, Brazil.
Spitzer
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V
Schapoval
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Schenkel
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EP
D000700:Analgesics / Q000302:isolation & purification; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification*; D000975:Antioxidants / Q000302:isolation & purification; D000998:Antiviral Agents / Q000302:isolation & purification; D001938:Brazil; D002109:Caffeic Acids / Q000302:isolation & purification; D002726:Chlorogenic Acid / Q000302:isolation & purification; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D004487:Edema / Q000188:drug therapy; D044948:Flavonols; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011392:Proline / Q000302:isolation & purification; D011794:Quercetin / Q000031:analogs & derivatives* / Q000302:isolation & purification; D051381:Rats; D012431:Rutin / Q000302:isolation & purification
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000998:Antiviral Agents; D002109:Caffeic Acids; D044948:Flavonols; D010936:Plant Extracts; C047368:3-methylquercetin; D002726:Chlorogenic Acid; D012431:Rutin; C021304:hyperoside; D011392:Proline; D011794:Quercetin; C040048:caffeic acid