title: Relative inhibition of insect phenoloxidase by cyclic fungal metabolites from insect and plant pathogens.
abstract: The fungal metabolite kojic acid, which is produced by Aspergillus and Penicillium species fungi that may be pathogens of both insects and plants, was a significant inhibitor of phenoloxidase of different representative beetle and caterpillar insect species. Fusaric acid and picolinic acid, produced by Fusarium spp., were also significant inhibitors of phenoloxidase, while dipicolinic acid and beauvericin were ineffective at concentrations tested. Previous reports of the ability of kojic and fusaric acid to inhibit defensive enzymes of plants suggest that these compounds may be important in allowing the producing fungi to be pathogens of both insects and plants.
authors: USDA, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, IL 61604, USA.
authors: P F
authors: PF
authors: Dowd
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000378:metabolism; D002686:Chitin; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000633:toxicity*; D005669:Fusaric Acid / Q000633:toxicity*; D005670:Fusarium / Q000378:metabolism; D006458:Hemolymph / Q000187:drug effects / Q000201:enzymology; D019476:Insect Proteins / Q000187:drug effects / Q000378:metabolism; D007313:Insecta / Q000187:drug effects* / Q000201:enzymology; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010407:Penicillium / Q000378:metabolism; D010848:Picolinic Acids / Q000633:toxicity*; D011753:Pyrones / Q000633:toxicity*; D018411:Spodoptera / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D019476:Insect Proteins; D010848:Picolinic Acids; D011753:Pyrones; D002686:Chitin; C011890:kojic acid; D014442:Monophenol Monooxygenase; D005669:Fusaric Acid; C030614:picolinic acid