Bone mineral metabolism in adults with beta-thalassaemia major and intermedia.
Bone disease is an important cause of morbidity in older patients with beta-thalassaemia major and intermedia. We studied 27 women and 23 men with beta-thalassaemia major (37) and intermedia (13) whose mean age was 32.3 +/- 9.7 years. Bone mineral density (BMD) of the lumbar spine, femoral neck and distal radius was determined by dual-energy X-ray absorbiometry (DXA). The longitudinal change in BMD over a mean of 5.6 years was determined in 19 patients. Serum 25-hydroxyvitamin D, insulin growth factor-1 (IGF-1), bone formation markers bone-alkaline phosphatase, osteocalcin and the resorption marker urinary N-telopeptide cross-linked type 1 collagen (NTx) were determined. The BsmI vitamin D receptor (VDR) gene polymorphism was analysed. Reduced BMD (Z-score < -2) was present in 89%, 62% and 73% of patients in the spine, hip and radius respectively. Vitamin D deficiency was found in 62%, decreased IGF-1 in 72% and increased urinary NTx in 84% of patients. Serum IGF-1 correlated with spine and hip BMD (r = 0.4, r = 0.39, P < 0.01 respectively), and NTx correlated with the hip BMD Z-score (r = 0.35 P < 0.05). The mean annual percentage change in spine BMD was -1.36%. Patients with the VDR BB genotype had lower spine BMD than patients with the bb genotype. In conclusion, bone loss continues in adult thalassaemia patients and is associated with increased bone resorption and decreased IGF-1. The BsmI VDR gene polymorphism is associated with osteopenia in thalassaemia.
Dresner Pollack
R
R
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel. rivkap@md2.huji.ac.il
Rachmilewitz
E
E
Blumenfeld
A
A
Idelson
M
M
Goldfarb
A W
AW
D015652:25-Hydroxyvitamin D 2 / Q000097:blood; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D016009:Chi-Square Distribution; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D005260:Female; D005272:Femur Neck; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism*; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000652:urine; D011110:Polymorphism, Genetic; D011884:Radius; D018167:Receptors, Calcitriol / Q000235:genetics; D014808:Vitamin D Deficiency / Q000150:complications; D017086:beta-Thalassemia / Q000150:complications / Q000235:genetics / Q000378:metabolism*
D015415:Biomarkers; D024042:Collagen Type I; D008903:Minerals; D010455:Peptides; D018167:Receptors, Calcitriol; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D015652:25-Hydroxyvitamin D 2; D007334:Insulin-Like Growth Factor I; D003094:Collagen; D000469:Alkaline Phosphatase