Successful anticoagulation with hirudin in a patient with mesenteric venous thrombosis and multiple coagulation abnormalities.
A case of multiple thrombotic diatheses discovered in the setting of mesenteric venous infarction is discussed. The patient had deficiencies of protein C, protein S, antithrombin III; was heterozygous for factor V Leiden; and had polycythemia vera. Adequate anticoagulation could not be established with heparin administration and hirudin was used. The diagnosis of mesenteric venous infarction, thrombotic tendency of multiple coagulation diatheses, and use of hirudin are discussed.
Gordon
M B
MB
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
Beckman
J A
JA
D020016:Activated Protein C Resistance / Q000150:complications; D020152:Antithrombin III Deficiency / Q000150:complications; D001778:Blood Coagulation Disorders / Q000150:complications*; D005165:Factor V / Q000235:genetics; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D024764:Hirudin Therapy; D006801:Humans; D007238:Infarction / Q000473:pathology / Q000601:surgery; D007421:Intestine, Small / Q000098:blood supply / Q000473:pathology; D008642:Mesenteric Veins; D008875:Middle Aged; D011087:Polycythemia Vera / Q000150:complications; D020151:Protein C Deficiency / Q000150:complications; D018455:Protein S Deficiency / Q000150:complications; D020246:Venous Thrombosis / Q000150:complications* / Q000188:drug therapy* / Q000601:surgery
D005343:Fibrinolytic Agents; C095381:factor V Leiden; D005165:Factor V