The influence of Helicobacter pylori infection on gastrin and somatostatin values present in serum.
OBJECTIVE
Recent studies on the role of Helicobacter pylori in pathogenesis of duodenal ulcers have focused on the mechanism by which H. pylori infections causes exaggerated gastrin release.


METHODS
We compared the gastrin and somatostatin serum values between two groups of patients; 37 H. pylori-positive ones and 29 H. pylori-negative ones. We applied radioimmunoassay technique to determine the gastrin and somatostatin values in serum. H. pylori was confirmed by urease test and by histopathological color according to Giemsa.


RESULTS
The level of gastrin in the serum of Helicobacter pylori-positive patients with chronic gastritis were significantly higher in relation to H. pylori-negative patients. The somatostatin concentration in the sera of H. pylori-positive patients with duodenal ulcer (16.27 +/- 9.49 pg/mL) were less in comparison with those without duodenal ulcer (23.25 +/- 13.59 pg/mL).


CONCLUSIONS
The results suggest that H. pylori infection suppresses the somatostatin secretion.
Mihaljevic
S
S
Clinic of Internal Medicine, Osijek School of Medicine, Clinical Hospital Osijek Huttlerova, Croatia.
Katicic
M
M
Karner
I
I
Vuksic-Mihaljevic
Z
Z
Dmitrovic
B
B
Ivandic
A
A
D000328:Adult; D000368:Aged; D005260:Female; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000097:blood* / Q000150:complications; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013004:Somatostatin / Q000097:blood*
D005755:Gastrins; D013004:Somatostatin