Fos expression in female hamsters after various stimuli associated with mating.
Detection of the expression of c-fos mRNA or its protein product, Fos, has been used to indicate differences in neuronal response to exogenous stimuli. Factors contributing to differences in Fos expression as a result of various stimuli associated with mating have been extensively studied in the female rat. Less is known about the factors that contribute to Fos expression in female hamsters. Female hamsters differ from female rats in several aspects of sexual behavior; therefore, it seems likely that Fos expression may also differ. The purpose of this study was to determine which factors associated with mating selectively affect Fos expression in the female hamster. Animals were ovariectomized, hormone treated, and then exposed to several behavioral conditions. Fos expression in several brain areas was then assessed via immunocytochemistry (ICC). As has been found by others, mating increases Fos immunoreactivity in a number of brain regions. Specifically, vaginal-cervical stimulation (VCS) was determined to be the salient factor contributing to Fos expression in the preoptic area (POA) and bed nucleus of the stria terminalis (BNST) of ovariectomized hormone primed female hamsters that received a mating interaction.
Ramos
S M
SM
Psychology Department, Tufts University, Medford, MA 02155, USA. sramos@caregroup.harvard.edu
DeBold
J F
JF
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D002584:Cervix Uteri / Q000502:physiology; D006224:Cricetinae; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D007150:Immunohistochemistry; D008647:Mesocricetus; D010052:Ovariectomy; D010812:Physical Stimulation; D011187:Posture / Q000502:physiology; D011301:Preoptic Area / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D012686:Septal Nuclei / Q000187:drug effects / Q000378:metabolism; D012726:Sexual Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D012919:Social Behavior; D014621:Vagina / Q000502:physiology; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism
D004967:Estrogens; D016760:Proto-Oncogene Proteins c-fos; D011374:Progesterone