title: Assessment of brainstem function in Chiari II malformation utilizing brainstem auditory evoked potentials (BAEP), blink reflex and masseter reflex.
abstract: Brainstem dysfunction was evaluated in 67 patients with myelomeningocele and Chiari II malformation using brainstem auditory evoked potentials (BAEP), blink reflex (BR) and masseter reflex (MR). Signs and symptoms related to Chiari II malformation were observed in 18 patients while 49 patients had normal brainstem findings. BAEP and BR showed a higher sensitivity of brainstem involvement than MR (BAEP=1.0, BR=0.83, MR=0.50). BR, and in particular, MR were of higher accuracy (BR=0.52, MR=0.72) than BAEP (0.39) in separating patients with brainstem signs and symptoms related to Chiari II malformation. We feel that this is due to anatomic and physiologic peculiarities of the brainstem structures mediating BR and MR. Our results suggest that brainstem reflexes can support the decision of further treatment.
authors: Department of Neurology, University hospital Mainz, Johannes-Gutenberg University, 55101, Mainz, Germany. koehler@neurologie.klinik.uni-mainz.de
authors: J
authors: J
authors: Koehler
authors: M
authors: M
authors: Schwarz
authors: R
authors: R
authors: Boor
authors: C
authors: C
authors: Hölker
authors: H C
authors: HC
authors: Hopf
authors: D
authors: D
authors: Voth
authors: P P
authors: PP
authors: Urban
authors: A
authors: A
authors: Ermert
mesh_terms: D000293:Adolescent; D000328:Adult; D001139:Arnold-Chiari Malformation / Q000150:complications / Q000503:physiopathology*; D001767:Blinking; D001933:Brain Stem / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology; D008297:Male; D008406:Masseter Muscle / Q000503:physiopathology*; D008591:Meningomyelocele / Q000150:complications / Q000503:physiopathology*; D012018:Reflex; D012680:Sensitivity and Specificity