Synthetically modified DNAs as substrates for polymerases.
DNA polymerase enzymes process their natural substrates with very high specificity. Yet recent experiments have shown that these enzymes can also process DNA in which the backbone or bases are modified to a surprising degree. Such experiments have important implications in understanding the mechanisms of DNA replication, and suggest important biotechnological uses as well.
Kool
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Department of Chemistry, Stanford University, Stanford, CA 94305, USA. kool@stanford.edu
D000818:Animals; D020029:Base Pairing; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004270:DNA, Circular / Q000737:chemistry; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D006801:Humans
D004270:DNA, Circular; D004247:DNA; D004259:DNA-Directed DNA Polymerase