The role of G proteins in the psychobiology and treatment of affective disorders and their integration with the neurotransmitter hypothesis.
Heterotrimeric G proteins are a crucial point of convergence in the transmission of signals from a variety of primary messengers and their membrane receptors to downstream intracellular second messenger effector enzymes and ionic channels. Thus, these proteins have raised increasing interest in the clinical perspective of altered G protein function. This article addresses the most recent significant findings regarding the role of G proteins in the pathophysiology of mood disorders and in the molecular mechanisms underlying the treatment of these disorders, with emphasis on biochemical and genetic approaches.
Avissar
S
S
Department of Clinical Pharmacology, Ben Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel.
D018692:Antimanic Agents / Q000494:pharmacology*; D019204:GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D018021:Lithium Chloride / Q000494:pharmacology*; D019964:Mood Disorders / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D015398:Signal Transduction
D018692:Antimanic Agents; D019204:GTP-Binding Proteins; D018021:Lithium Chloride