title: Recurrent chromosome aberrations in fibrous dysplasia of the bone: a report of the CHAMP study group. CHromosomes And MorPhology.
abstract: The nosologic status of fibrous dysplasia (FD), a well-known and relatively common bone lesion, is controversial. Information collected by the CHromosomes And MorPhology (CHAMP) study group on published and unpublished cases of fibrous dysplasia shows the presence of clonal chromosome changes in at least a proportion of these lesions. The chromosome aberrations found in FD lesions have been quite variable and have included both structural and numerical changes. Two of the three cases investigated at the study group had trisomy 2 as the sole acquired anomaly. Combined with previously published data, +2 and rearrangements involving chromosome band 12p13 have each been detected in 3 of 8 cases with abnormal karyotype of 11 in which chromosomal analysis has been performed, suggesting that FD is a neoplastic lesion rather than a "dysplastic" process, as has been generally believed and as implied by its very name.
authors: Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. pdalcin@rics.bwh.harvard.edu
authors: P
authors: P
authors: Dal Cin
authors: R
authors: R
authors: Sciot
authors: P
authors: P
authors: Brys
authors: I
authors: I
authors: De Wever
authors: H
authors: H
authors: Dorfman
authors: C D
authors: CD
authors: Fletcher
authors: K
authors: K
authors: Jonsson
authors: N
authors: N
authors: Mandahl
authors: F
authors: F
authors: Mertens
authors: F
authors: F
authors: Mitelman
authors: J
authors: J
authors: Rosai
authors: A
authors: A
authors: Rydholm
authors: I
authors: I
authors: Samson
authors: G
authors: G
authors: Tallini
authors: H
authors: H
authors: Van den Berghe
authors: R
authors: R
authors: Vanni
authors: H
authors: H
authors: Willen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002869:Chromosome Aberrations; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male