title: Exercise does not induce oxidative stress in trained heart transplant recipients.
abstract: OBJECTIVE
  The objectives of this study were twofold: 1) to determine the effect of incremental exercise to volitional fatigue on plasma levels of lipid peroxidation (malondialdehyde) in heart transplant recipients (HRT) and 2) to examine blood antioxidant capacity in HTR by assessment of antioxidant enzyme activities and vitamin E levels.
  
  
  METHODS
  Seven endurance-trained HTR (mean +/- SD; age 39.7 +/- 12.8 yr) and seven endurance-trained healthy, age-matched control subjects (HC) (mean age 40.6 +/- 10.7 yr) performed a symptom-limited incremental exercise test on a cycle ergometer. Venous blood samples were obtained at rest, exercise, and during recovery and analyzed for plasma levels of malondialdehyde (MDA) as well as markers of blood antioxidant capacity. After exercise and during recovery, all dependent measures were corrected for plasma volume changes induced by exercise. Significance was established at (P < 0.05).
  
  
  RESULTS
  No group differences existed in plasma levels of MDA at rest. Further, graded exercise did not alter plasma levels of MDA in either group. Resting erythrocyte glutathione peroxidase (GPX) activity was significantly lower and erythrocyte superoxide dismutase (SOD) activity was higher in HTR compared with HC. Finally, at rest, no group differences existed in plasma GPX activity or vitamin E levels.
  
  
  CONCLUSIONS
  Graded exercise to fatigue does not promote an increase in oxidative stress in blood of exercise trained HTR. Therefore, physical exercise does not appear to pose an oxidative-stress risk for these patients.
authors: Laboratoire de Physiologie des Adaptations, Faculté de Médecine Cochin-Port-Royal, Service d'Explorations Fonctionnelles et de Physiopathologie de L'Exercice, Paris, France. Lijimenez@aol.com
authors: L
authors: L
authors: Jimenez
authors: G
authors: G
authors: Lefevre
authors: R
authors: R
authors: Richard
authors: A
authors: A
authors: Duvallet
authors: M
authors: M
authors: Rieu
mesh_terms: D000328:Adult; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D010101:Oxygen Consumption; D014810:Vitamin E / Q000097:blood
chemical_list: D014810:Vitamin E; D008315:Malondialdehyde