Effect of azithromycin on murine arteriosclerosis exacerbated by Chlamydia pneumoniae.
Chlamydia pneumoniae infection can exacerbate atherosclerosis in animals. To test the hypothesis that antibiotic therapy inhibits the atherogenic effects of C. pneumoniae infection, 10-week-old apolipoprotein E (ApoE) null mice were infected with C. pneumoniae or placebo, were treated for 2 weeks after infection with azithromycin or placebo, and were killed at 20 weeks of age. Infection did not affect the size of the aortic lesion, and antibiotic treatment had no effect. Another group of mice, 12-week-old ApoE mice, were infected with C. pneumoniae or placebo, were treated for 2 weeks after infection with azithromycin or placebo, and were killed at 26 weeks of age. C. pneumoniae infection increased the size of the lesion in infected mice, but azithromycin did not reduce the size of the aortic lesion in infected mice. Therefore, immediate therapy of acute infection may be necessary to prevent the proatherogenic effects of C. pneumoniae infection.
Rothstein
N M
NM
Division of Cardiology, Dept. of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Quinn
T C
TC
Madico
G
G
Gaydos
C A
CA
Lowenstein
C J
CJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000097:blood; D001011:Aorta / Q000473:pathology; D001057:Apolipoproteins E / Q000172:deficiency; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D017963:Azithromycin / Q000627:therapeutic use*; D023521:Chlamydophila Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D005260:Female; D008055:Lipids / Q000032:analysis; D051379:Mice; D008810:Mice, Inbred C57BL; D016133:Polymerase Chain Reaction
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D001057:Apolipoproteins E; D008055:Lipids; D017963:Azithromycin