[Mechanisms of steroid osteoporosis development in patients with hormone-dependent bronchial asthma].
OBJECTIVE
To examine mechanisms of steroid osteoporosis development in patients with hormone-dependent bronchial asthma (BA).


METHODS
The trial included 73 patients with hormone-dependent BA, 19 BA patients who have never taken oral steroid hormones and 15 healthy subjects.


RESULTS
By computed tomography of the lumbar spine, bone tissue density in steroid-dependent BA was significantly decreased vs BA patients who were not treated with steroids. Osteopenia was discovered in 61.9% of the examinees who have received oral glucocorticoids. Development of osteopenia in this case was not dependent of the steroids dose and duration of the treatment. Patients with hormone-dependent BA vs healthy subjects had higher 24-h urine calcium excretion, normal levels of parathyroid hormones, calcitonin, low concentrations of 25-oxyvitamin D3, osteocalcin in the serum. Three subgroups of patients with osteopenia were identified according to the statistics: with prevalent resorption of bone tissues (24.1%), with low concentrations of vitamin D3 and osteocalcin (52.6%), with highly active resorption in combination with low vitamin D3 and weak function of osteoblasts (23.3%).


CONCLUSIONS
Mechanisms of steroid osteoporosis development are heterogeneous. This should be considered in its treatment.
Emel'ianov
A V
AV
Shevelev
S E
SE
Murzin
B A
BA
Amosov
V I
VI
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015519:Bone Density / Q000187:drug effects; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000652:urine; D018450:Disease Progression; D005260:Female; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D010024:Osteoporosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood; D011859:Radiography
D015415:Biomarkers; D005938:Glucocorticoids; D010281:Parathyroid Hormone; D015675:Osteocalcin; D002116:Calcitonin; D002118:Calcium