Mouse models of lipodystrophy.
Lipodystrophies are a group of heterogeneous diseases characterized by the loss of adipose tissue and by abnormalities of carbohydrate and lipid metabolism, including insulin resistance, diabetes, and hyperlipidemia. In this review, we describe several mouse models that recapitulate various aspects of the lipodystrophy syndrome, offering insights into the etiology of this condition and potential therapeutic approaches. Studies on these mice suggest that adipose is the primary tissue affected in lipodystrophy, and that secondary leptin deficiency may be responsible for the associated insulin resistance.
Reue
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Department of Medicine, University of California, Los Angeles, 11301 Wilshire Blvd., Building 113, Room 312, Los Angeles, CA 90073, USA. reuek@ucla.edu
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D000818:Animals; D004195:Disease Models, Animal; D008060:Lipodystrophy / Q000235:genetics / Q000503:physiopathology*; D051379:Mice; D008822:Mice, Transgenic