title: Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock.
abstract: OBJECTIVE
  To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock.
  
  
  METHODS
  A prospective clinical study in a university hospital intensive care unit.
  
  
  METHODS
  20 patients in septic shock. Patients received iloprost infusion (1 ng/kg per minute) for 24 h.
  
  
  RESULTS
  PDR was determined by a femoral arterial fiberoptic catheter before, 1, 6, and 24 h after start and 1 h after end of iloprost infusion. PDR increased significantly 24 h after start of iloprost infusion (baseline: 13.9 +/- 1.7% vs. 18.6 +/- 2.2%/min) and decreased 1 h after end of infusion (13.7 +/- 1.7%/min; p < 0.002). There was no change in pHi, cardiac index, mean arterial pressure, heart rate, central venous pressure, or intrathoracic blood volume index.
  
  
  CONCLUSIONS
  Administration of the stable prostacyclin analogue iloprost significantly increases PDR, indicating improvement in liver function.
authors: Klinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Charité, Berlin, Germany. christian.lehmann@charite.de
authors: C
authors: C
authors: Lehmann
authors: K
authors: K
authors: Taymoorian
authors: H
authors: H
authors: Wauer
authors: D
authors: D
authors: Krausch
authors: J
authors: J
authors: Birnbaum
authors: W J
authors: WJ
authors: Kox
mesh_terms: D000328:Adult; D000368:Aged; D004396:Coloring Agents / Q000493:pharmacokinetics*; D016903:Drug Monitoring / Q000295:instrumentation / Q000379:methods; D004395:Dye Dilution Technique / Q000295:instrumentation; D011464:Epoprostenol / Q000031:analogs & derivatives*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016285:Iloprost / Q000494:pharmacology / Q000627:therapeutic use*; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D011446:Prospective Studies; D012772:Shock, Septic / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004396:Coloring Agents; D014665:Vasodilator Agents; D011464:Epoprostenol; D007208:Indocyanine Green; D016285:Iloprost