alpha4 integrin is expressed in a subset of cranial neural crest cells and in epicardial progenitor cells during early mouse development.
By RNA in situ hybridization and immunohistochemical analyses of early stage mouse embryos, we find that alpha 4 integrin gene is expressed in migratory cranial neural crest cells originating from the presumptive forebrain, midbrain, and rhombomeres 1 and 2 of the presumptive hindbrain. alpha 4 is also expressed in epicardial progenitor cells in the septum transversum that migrate to the heart.
Pinco
K A
KA
Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, baltimore, MD 21205, USA.
Liu
S
S
Yang
J T
JT
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis*; D004622:Embryo, Mammalian / Q000378:metabolism; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D039441:Integrin alpha4; D008636:Mesencephalon / Q000196:embryology; D051379:Mice; D009432:Neural Crest / Q000196:embryology*; D010496:Pericardium / Q000196:embryology*; D016548:Prosencephalon / Q000196:embryology; D012313:RNA / Q000378:metabolism; D012249:Rhombencephalon / Q000196:embryology; D013234:Stem Cells / Q000378:metabolism*; D013997:Time Factors
D015703:Antigens, CD; D039441:Integrin alpha4; D012313:RNA