Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease.
There are several adaptor proteins associated with clathrin coated vesicles. Among them are AP180 and AP-2. We and others have previously described synaptic localization of AP180. AP180 immunoreactivity is altered in both the superior frontal gyrus and hippocampus in Alzheimer's disease (AD). We here investigate the location and alteration of another adaptor protein, AP-2. In contrast to AP180, we have found that AP-2 is expressed by both neurons and glia. Furthermore, the only noticeable change of AP-2 in AD is a loss of its immunoreactivity in layer II of the superior frontal gyrus.
Yao
P J
PJ
Center for Aging and Developmental Biology, University of Rochester Medical Center, Box 645, 601 Elmwood Avenue, Rochester, NY 14642, USA. pamela_yao@urmc.rochester.edu
Weimer
J M
JM
O'Herron
T M
TM
Coleman
P D
PD
D033942:Adaptor Proteins, Vesicular Transport; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002460:Cell Line; D004791:Enzyme Inhibitors / Q000032:analysis; D005260:Female; D005625:Frontal Lobe / Q000166:cytology* / Q000473:pathology; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D034041:Monomeric Clathrin Assembly Proteins; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009457:Neuroglia / Q000166:cytology* / Q000473:pathology; D009474:Neurons / Q000166:cytology* / Q000473:pathology; D009928:Organ Specificity; D010750:Phosphoproteins / Q000032:analysis*; D012016:Reference Values; D013569:Synapses / Q000473:pathology / Q000648:ultrastructure
D033942:Adaptor Proteins, Vesicular Transport; D004791:Enzyme Inhibitors; D034041:Monomeric Clathrin Assembly Proteins; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; C439023:clathrin assembly protein AP180