Growth in North American white children with neurofibromatosis 1 (NF1).
OBJECTIVE
To analyse the distributions of and generate growth charts for stature and occipitofrontal circumference (OFC) in neurofibromatosis 1 (NF1) patients.


METHODS
Cross sectional database survey.


METHODS
The National Neurofibromatosis Foundation International Database (NFDB) includes clinical information on NF1 patients from 14 participating centres in North America.


METHODS
A total of 569 white, North American, NF1 patients, 55% female and 45% male.


METHODS
Stature and OFC measurements of NF1 patients were compared to age and sex matched population norms using z score standardisation and centile curves.


RESULTS
The distributions of stature and OFC are shifted and unimodal among NF1 patients; 13% of patients have short stature (>/=2 standard deviations below the population mean) and 24% have macrocephaly (OFC >/=2 standard deviations above the population mean).


CONCLUSIONS
Alterations of stature and OFC are not limited to NF1 patients with frank short stature or macrocephaly.
Szudek
J
J
Department of Medical Genetics, The University of British Columbia, 222-6174 University Boulevard, Vancouver, BC V6T 1Z3, Canada. szudek@unixg.ubc.ca
Birch
P
P
Friedman
J M
JM
D000293:Adolescent; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006128:Growth / Q000502:physiology*; D006130:Growth Disorders / Q000453:epidemiology / Q000503:physiopathology*; D006257:Head / Q000254:growth & development; D006801:Humans; D008297:Male; D009456:Neurofibromatosis 1 / Q000453:epidemiology / Q000503:physiopathology*; D009656:North America / Q000453:epidemiology; D012016:Reference Values; D044465:White People