[Undesirable drug interactions of hypolipemic drugs].
The paper presents undesirable hypolipaemic drug interactions. Statins interactions are mainly connected with their hepatic metabolism by cytochrome P-450 isoenzymes. Most statins are metabolised by the CYP3A4 izoenzyme (lovastatin, simvastatin, atorvastatin, cerivastatin). The CYP3A4 isoenzyme is also responsible for the metabolism of wide range of drugs. The use of the combination of statins and some other drugs metabolised by, or affecting the activity of this same enzyme, may increase the risk of myopathy and rhabdomyolysis. It has been emphasized that pravastatin--and fluvastatin interactions are rarer and weaker than interactions of other statins. The most common appearance of interactions of hypolipaemic drugs, also other than statins have been presented.
Chojnowska-Jezierska
J
J
Zakładu Farmakologii Klinicznej IMW WAM w łodz.
D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology; D008099:Liver / Q000378:metabolism
D000960:Hypolipidemic Agents; D003577:Cytochrome P-450 Enzyme System