Automation of X-ray crystallography.
Structure-based biological discovery is entering a new era with the development of industrialized macromolecular structure determination pipelines. Intense, highly focused X-rays from integrated synchrotron radiation beam lines combined with significant advances in protein expression, purification, and micro-crystallization automation allow for the full streamlining of the traditionally tedious and time consuming process of determining the three dimensional structures of macromolecules.
Abola
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Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Kuhn
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P
Earnest
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Stevens
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RC
D001331:Automation / Q000379:methods*; D003460:Crystallization; D018360:Crystallography, X-Ray / Q000379:methods*; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013048:Specimen Handling / Q000379:methods; D017356:Synchrotrons
D011506:Proteins