Case report: human neonatus with spina bifida, clubfoot, situs inversus totalis and cerebral deformities: sequence or accident?
An unreported coincidence of malformations has been studied by anatomical dissection in a mature male fetus. Auxiliary, this fetus was examined by computed tomography and the skeletal malformations were three-dimensionally reconstructed. The organs of the thorax as well as of the abdomen showed a visceral inversion. In the lumbar region, a hyperkyphosis was detected in addition to a split-notochord. A hydrocephalus internus with enlarged lateral ventricles and an agenesis of the corpus callosum were apparent. The lower extremities were dystrophic with both showing a talipes equinovarus-deformation. Following the case report, we discuss if this is coincidental or manifestations in consequence of one defect.
Piegger
J
J
Institut für Anatomie und Histologie, Leopold-Franzens-Universität, Innsbruck, Austria. j.piegger@uibk.ac.at
Gruber
H
H
Fritsch
H
H
D000015:Abnormalities, Multiple / Q000473:pathology*; D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D003025:Clubfoot / Q000150:complications / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007866:Leg / Q000002:abnormalities; D008297:Male; D016135:Spinal Dysraphism / Q000150:complications / Q000473:pathology*; D014781:Viscera / Q000002:abnormalities* / Q000473:pathology