title: Gene expression profiles in normal and Otx2-/- early gastrulating mouse embryos.
abstract: The mouse Otx2 gene is a homeobox transcription factor required as early as gastrulation for the proper development of the head. We compared gene expression profiles in wild-type and Otx2(-/-) 6.5 days postcoitum embryos by using a serial analysis of gene expression assay adapted to microdissected structures. Among a broader list, the study of six genes found to be differentially expressed allows defining a role for Otx2 in the orchestration of cell movements leading to the adequate organization of the embryo before gastrulation.
authors: Unité d'Embyologie Moléculaire, Unité de Recherche Associée 1947, Centre National de la Recherche Scientifique, and Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 25 Rue du Docteur Roux, 75724, Paris Cedex 15, France.
authors: L
authors: L
authors: Zakin
authors: B
authors: B
authors: Reversade
authors: B
authors: B
authors: Virlon
authors: C
authors: C
authors: Rusniok
authors: P
authors: P
authors: Glaser
authors: J M
authors: JM
authors: Elalouf
authors: P
authors: P
authors: Brulet
mesh_terms: D000818:Animals; D055313:Cystatin B; D015891:Cystatins / Q000235:genetics; D016207:Cytokines; D004475:Ectoderm; D005314:Embryonic and Fetal Development; D004707:Endoderm; D020224:Expressed Sequence Tags; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics; D005775:Gastrula / Q000502:physiology*; D020869:Gene Expression Profiling; D005838:Genotype; D006257:Head / Q000196:embryology*; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D055457:Nodal Protein; D051857:Otx Transcription Factors; D063151:Polycomb Repressive Complex 2; D011506:Proteins / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors; D016212:Transforming Growth Factor beta / Q000235:genetics; D051153:Wnt Proteins; D060528:Wnt4 Protein
chemical_list: C524994:CSTB protein, human; C110586:Cer1 protein, mouse; C524992:Cstb protein, mouse; D015891:Cystatins; D016207:Cytokines; C501126:DKK1 protein, human; C501127:Dkk1 protein, mouse; C491488:EED protein, human; C107275:Eed protein, mouse; C078492:HHEX protein, human; C513080:Hhex protein, mouse; D018398:Homeodomain Proteins; D036341:Intercellular Signaling Peptides and Proteins; C526007:NODAL protein, human; D009419:Nerve Tissue Proteins; D055457:Nodal Protein; C526008:Nodal protein, mouse; C497659:OTX2 protein, human; D051857:Otx Transcription Factors; C497660:Otx2 protein, mouse; D011506:Proteins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C555581:WNT4 protein, human; D051153:Wnt Proteins; D060528:Wnt4 Protein; C555582:Wnt4 protein, mouse; C108526:fibroblast growth factor 15, mouse; D005346:Fibroblast Growth Factors; D055313:Cystatin B; D063151:Polycomb Repressive Complex 2