Use of lufenuron for treating fungal infections of dogs and cats: 297 cases (1997-1999).
OBJECTIVE
To evaluate use of lufenuron for treating cutaneous fungal infections in dogs and cats.


METHODS
Retrospective study.


METHODS
156 dogs and 201 cats with dermatophytosis or superficial dermatomycoses.


METHODS
Medical records were reviewed for dogs and cats that had been treated for dermatophytosis or other fungal infections by administration of lufenuron and 18 dogs and 42 cats that were not treated and served as a control group.


RESULTS
Dogs were treated once by oral administration of lufenuron tablets at doses ranging from 54.2 to 68.3 mg/kg (24.6 to 31.0 mg/lb) of body weight. Samples of skin, scrapings, and hair were obtained daily from 14 dogs with dermatophytosis; mean durations from time of treatment to time of negative fungal culture results and resolution of gross lesions were 14.5 and 20.75 days, respectively. In all treated dogs, gross lesions resolved within approximately 21 days. Cats were treated once by oral administration of lufenuron suspension in doses ranging from 51.2 to 266 mg/kg (23.3 to 120.9 mg/lb). Samples were obtained daily from 23 cats; mean durations from time of treatment to time of negative fungal culture results and resolution of gross lesions were 8.3 and 12 days, respectively. Time to resolution of lesions in most untreated control animals was approximately 90 days. Adverse effects of treatment were not detected.


CONCLUSIONS
Results of this study suggest that lufenuron provides an effective, convenient, and rapid method for treating fungal infections in dogs and cats.
Ben-Ziony
Y
Y
Ben Ziony's Animal Hospitals Ltd, Kiryat Tivon, Israel.
Arzi
B
B
D000284:Administration, Oral; D000505:Alopecia / Q000662:veterinary; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use*; D001774:Blood Chemical Analysis; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D002371:Cat Diseases / Q000188:drug therapy / Q000382:microbiology*; D002415:Cats; D003881:Dermatomycoses / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology*; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D012189:Retrospective Studies; D005466:Fluorocarbons
D001549:Benzamides; D007306:Insecticides; C070364:fluphenacur; D005466:Fluorocarbons