The TRANSFAC system on gene expression regulation.
The TRANSFAC database on transcription factors and their DNA-binding sites and profiles (http://www.gene-regulation.de/) has been quantitatively extended and supplemented by a number of modules. These modules give information about pathologically relevant mutations in regulatory regions and transcription factor genes (PathoDB), scaffold/matrix attached regions (S/MARt DB), signal transduction (TRANSPATH) and gene expression sources (CYTOMER). Altogether, these distinct database modules constitute the TRANSFAC system. They are accompanied by a number of program routines for identifying potential transcription factor binding sites or for localizing individual components in the regulatory network of a cell.
Wingender
E
E
Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany. ewi@gbf.de
Chen
X
X
Fricke
E
E
Geffers
R
R
Hehl
R
R
Liebich
I
I
Krull
M
M
Matys
V
V
Michael
H
H
Ohnhäuser
R
R
Prüss
M
M
Schacherer
F
F
Thiele
S
S
Urbach
S
S
D001665:Binding Sites; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D016208:Databases, Factual; D005786:Gene Expression Regulation; D020407:Internet; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D004268:DNA-Binding Proteins; D014157:Transcription Factors