[Effect of diazepam on the metabolic and morphometric parameters of neurons in the dorsal hippocampus in normal and stressed rats].
Diazepam (0.5 mg/kg) decreases the swimming-stress-induced activation of the pyramidal neurons in the dorsal hippocamp. This is manifested by a decrease in the stress-induced glycogen consumption, an increase in the RNA content, and (less pronounced) increased in the nucleocytoplasmic ratio.
Arushanian
E B
EB
Pharmacology Department, State Medical Academy, Ministry of Public Health of the Russian Federation, Stavropol, Russia.
Beĭer
E V
EV
Loktev
N A
NA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002467:Cell Nucleus; D003593:Cytoplasm; D003975:Diazepam / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008845:Microinjections; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D012313:RNA / Q000032:analysis; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism* / Q000473:pathology
D014151:Anti-Anxiety Agents; D012313:RNA; D006003:Glycogen; D003975:Diazepam