The intrinsic function of a motor system--from ion channels to networks and behavior.
The forebrain, brainstem and spinal cord contribution to the control of locomotion is reviewed in this article. The lamprey is used as an experimental model since it allows a detailed cellular analysis of the neuronal network underlying locomotion. The focus is on cellular mechanisms that are important for the pattern generation, as well as different types of pre- and postsynaptic modulation. This experimental model is bridging the gap between the molecular and cellular level to the network and behavioral level.
Grillner
S
S
Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE-171 77, Stockholm, Sweden. sten.grillner@neuro.ki.se
Cangiano
L
L
Hu
G
G
Thompson
R
R
Hill
R
R
Wallén
P
P
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology; D003198:Computer Simulation; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D007798:Lampreys; D008124:Locomotion / Q000502:physiology*; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology*; D009415:Nerve Net / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D016548:Prosencephalon / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology
D007473:Ion Channels; D018377:Neurotransmitter Agents