title: New triene-ansamycins, thiazinotrienomycins F and G and a diene-ansamycin, benzoxazomycin.
abstract: New triene-ansamycins designated thiazinotrienomycins F (TT-F) and G (TT-G) and a new diene-ansamycin, benzoxazomycin, were isolated from a culture broth of Streptomyces sp. MJ672-m3 and their structures were elucidated by spectroscopic analyses. The Mean Graphs of TT-G suggests that the tumor growth inhibitory activities are almost as strong as TT-B, in respect of GI50 and TGI against several human cancer cell lines.
authors: Institute of Microbial Chemistry, Tokyo, Japan.
authors: N
authors: N
authors: Hosokawa
authors: H
authors: H
authors: Naganawa
authors: M
authors: M
authors: Hamada
authors: H
authors: H
authors: Iinuma
authors: T
authors: T
authors: Takeuchi
authors: K S
authors: KS
authors: Tsuchiya
authors: M
authors: M
authors: Hori
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D008968:Molecular Conformation; D009593:Nitroimidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism; D013843:Thiazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009593:Nitroimidazoles; D013843:Thiazines; C417106:benzoxazomycin; C417108:thiazinotrienomycin F; C417107:thiazinotrienomycin G; D000409:Alanine