Volume-corrected mitotic index as a prognostic factor in oral squamous cell carcinomas.
In order to predict the prognosis of patients with oral squamous cell carcinomas, volume-corrected mitotic index (M/V index), as well as histopathological and clinical indices were estimated in 50 oral squamous cell carcinoma tumors. Histological malignancy (P = 0.0005), mode of invasion (P = 0.0168) and M/V index (P = 0.0093) showed a significant correlation with survival according to univariate survival analysis. According to multivariate survival analysis (Cox's regression model), the M/V index was the best predictor of the techniques studied of patient prognosis. The M/V index also showed significant correlation with DNA ploidy. The present results suggest that the M/V index is an important prognostic factor for oral carcinoma. Furthermore, the M/V index and DNA ploidy appear to provide similar prognostic information.
Imai
Y
Y
Department of Oral and Maxillofacial Surgery, Dokkyo University School of Medicine, 880 Kita-kobayashi, Mibu, 321-0293, Tochigi, Japan. yimai@dokkyomed.ac.jp
Sasaki
T
T
Fujibayashi
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index; D009062:Mouth Neoplasms / Q000235:genetics / Q000473:pathology*; D009333:Neck; D011003:Ploidies; D011379:Prognosis; D015996:Survival Rate