title: Proton magnetic resonance spectroscopy (1H-MRS) of the cerebellum in men with schizophrenia.
abstract: OBJECTIVE
  To investigate whether there are cerebellar vermis abnormalities in schizophrenia.
  
  
  METHODS
  Prospective imaging study with proton magnetic resonance spectroscopy (1H-MRS).
  
  
  METHODS
  Schizophrenia clinic at a large urban hospital.
  
  
  METHODS
  Twelve right-handed male patients with schizophrenia, and 12 control subjects with no psychiatric history.
  
  
  METHODS
  MRS data were acquired from a 2.0 x 2.0 x 2.0 cm volume of interest that included the entire cerebellar vermis.
  
  
  METHODS
  Spectral peak arising from N-acetylaspartate (NAA), phosphocreatine/creatine (Cr) and choline (Cho).
  
  
  RESULTS
  There were no significant differences between the patients with schizophrenia and the controls in cerebellar vermis ratios of NAA to Cr (p = 0.71) or Cho to Cr (p = 0.50).
  
  
  CONCLUSIONS
  This study does not support earlier structural studies that found abnormalities of the cerebellar vermis in schizophrenia, although it does support reported neurochemical studies. It does not rule out cerebellar involvement in schizophrenia through mechanisms such as aberrant circuitry. Larger in vivo structural/neurochemical and functional imaging studies in other parts of the cerebellum are needed.
authors: Department of Psychiatry, University of Alberta, Edmonton, Alta. ptibbo@pop.srv.ualberta.ca
authors: P
authors: P
authors: Tibbo
authors: C C
authors: CC
authors: Hanstock
authors: S
authors: S
authors: Asghar
authors: P
authors: P
authors: Silverstone
authors: P S
authors: PS
authors: Allen
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism* / Q000473:pathology; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology
chemical_list: D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline