title: 2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2.
abstract: Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 (22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.
authors: Ontogen Corporation, Carlsbad, CA 92009, USA.
authors: C
authors: C
authors: Zhang
authors: S
authors: S
authors: Sarshar
authors: E J
authors: EJ
authors: Moran
authors: S
authors: S
authors: Krane
authors: J C
authors: JC
authors: Rodarte
authors: K D
authors: KD
authors: Benbatoul
authors: R
authors: R
authors: Dixon
authors: A M
authors: AM
authors: Mjalli
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects*; D020650:Combinatorial Chemistry Techniques; D018432:Drug Resistance, Multiple; D006207:Half-Life; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D012016:Reference Values
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007093:Imidazoles