Granulocytic sarcoma with breast and skin presentation: a report of a case successfully treated by local radiation and systemic chemotherapy.
Granulocytic sarcoma (GS) is a rare extramedullary tumor composed of immature myeloid cells. It is usually associated with leukemia or other myeloproliferative disorders, but can also occur without overt hematologic disease, i.e. in patients with a normal bone marrow and no history of acute myelogenous leukemia. This primary extramedullary lesion may indeed represent a diagnostic and therapeutic dilemma for both the hematopathologist and oncologist. We describe a case of GS diagnosed in a nonleukemic patient and review the literature regarding the pathologic features and treatment of this condition.
Breccia
M
M
Dipartimento di Biotecnologie Cellulari ed Ematologia, Università La Sapienza, Roma, Italia.
Petti
M C
MC
Fraternali-Orcioni
G
G
Monarca
B
B
Latagliata
R
R
D'Elia
G M
GM
Mandelli
F
F
Pileri
S A
SA
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007938:Leukemia / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy
D000970:Antineoplastic Agents