title: Nasal obstruction as a risk factor for sleep apnoea syndrome.
abstract: Nasal obstruction has frequently been mentioned as a possible risk factor in obstructive sleep apnoea syndrome (OSAS). Over a 2-yr period, 541 unselected consecutive snorers referred for suspected breathing disorders during sleep were included to undergo posterior rhinomanometry. In addition cephalometric landmarks and body mass index (BMI) were obtained. Polysomnography was used to determine the number of abnormal respiratory events that occurred during sleep. OSAS was defined as 15 episodes, or more, of apnoea or hypopnoea per hour of sleep (AHI). Of the 541 consecutive snorers 528 underwent nasal resistance measurement by posterior rhinomanometry (failure rate: 2.4%). Patients with OSAS (259 patients) had higher nasal resistance than patients without OSAS (2.6+/-1.6 hPa x L x s(-1) versus 2.2+/-1.0 hPa x L x s(-1), respectively, p<0.005). A stepwise multiple regression analysis showed that BMI, male sex, nasal resistance, and cephalometric parameters were contributing factors to the AHI. The r2-value of the multiple regression analysis was 0.183. Nasal resistance contributed 2.3% of the variance (p<0.0001), whereas mandibular plane-hyoid distance, BMI, male sex and age contributed 6.2%, 4.6%, 3% and 1.3% of the variance, respectively. To conclude, daytime nasal obstruction is an independent risk factor for OSAS.
authors: Service de Physiologie-Explorations Fonctionnelles, Hôpital Raymond Poincaré, Garches, France.
authors: F
authors: F
authors: Lofaso
authors: A
authors: A
authors: Coste
authors: M P
authors: MP
authors: d'Ortho
authors: F
authors: F
authors: Zerah-Lancner
authors: C
authors: C
authors: Delclaux
authors: F
authors: F
authors: Goldenberg
authors: A
authors: A
authors: Harf
mesh_terms: D000403:Airway Resistance; D015992:Body Mass Index; D002508:Cephalometry; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D015508:Nasal Obstruction / Q000150:complications* / Q000503:physiopathology; D017286:Polysomnography; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000209:etiology* / Q000503:physiopathology