The pathology of REM sleep behavior disorder with comorbid Lewy body dementia.
A patient with REM sleep behavior disorder who subsequently developed probable Lewy body dementia is now reported to have a definite pathologic diagnosis of Lewy body dementia. Examination of brain revealed Lewy bodies as well as marked neuronal loss in brainstem monoaminergic nuclei-particularly locus coeruleus and substantia nigra-that inhibit cholinergic neurons in the pedunculopontine nucleus mediating atonia during REM sleep.
Turner
R S
RS
Veterans Administration Medical Center Geriatric Research Education and Clinical Center, Ann Arbor, MI 48105, USA. raymondt@umich.edu
D'Amato
C J
CJ
Chervin
R D
RD
Blaivas
M
M
D000368:Aged; D001921:Brain / Q000473:pathology*; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D012893:Sleep Wake Disorders / Q000473:pathology* / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology