A facile synthesis of perfluoroalkyl vinyl iodides and their palladium-mediated cross-coupling reactions.
Catalytic amounts of zinc, as low as 10 mol %, in the presence of trifluoroacetic acid (TFA) initiate the radical addition of perfluoroalkyl iodides to terminal alkynes with high regio- and stereoselectivities. Palladium-mediated cross-coupling of these (E)-perfluoroalkyl vinyl iodides allows for a facile synthesis of potentially useful fluoroorganic intermediates.
Jennings
M P
MP
Herbert C. Brown Center for Borane Research, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393, USA.
Cork
E A
EA
Ramachandran
P V
PV