title: Cytogenetic-morphologic correlations in aneurysmal bone cyst, giant cell tumor of bone and combined lesions. A report from the CHAMP study group.
abstract: Aneurysmal bone cyst and giant cell tumor of bone are relatively rare bone tumors that sometimes coexist. We examined the karyotypes of 3 aneurysmal bone cysts, 12 giant cell tumors, and 3 combined lesions. All aneurysmal bone cysts showed involvement of chromosome segments 17p11-13 and/or 16q22. In addition, in 1 of the 3 giant cell tumors with secondary aneurysmal bone cyst, both chromosome bands were rearranged as well, albeit not in a balanced translocation. Seven out of 12 giant cell tumors were characterized by telomeric associations. One giant cell tumor showed a dup(16)(q13q22), suggesting the presence of a (minor) secondary aneurysmal bone cyst component, despite the absence of histological proof. Our results, combined with literature data further substantiate that segments 16q22 and 17p11-13 are nonrandomly involved in at least some aneurysmal bone cysts, irrespective of subtype (primary, secondary, intra/extraosseous, solid or classic). These findings strongly suggest that some aneurysmal bone cysts are true neoplasms. In addition, telomeric associations are the most frequent chromosomal aberrations in giant cell tumor of bone, the significance of which remains elusive. In combined giant cell tumor/aneurysmal bone cyst each component seems to retain its own karyotypic abnormality.
authors: Department of Pathology, University of Leuven, Belgium. raf.sciot@uz.kuleuven.ac.be
authors: R
authors: R
authors: Sciot
authors: H
authors: H
authors: Dorfman
authors: P
authors: P
authors: Brys
authors: P
authors: P
authors: Dal Cin
authors: I
authors: I
authors: De Wever
authors: C D
authors: CD
authors: Fletcher
authors: K
authors: K
authors: Jonson
authors: N
authors: N
authors: Mandahl
authors: F
authors: F
authors: Mertens
authors: F
authors: F
authors: Mitelman
authors: J
authors: J
authors: Rosai
authors: A
authors: A
authors: Rydholm
authors: I
authors: I
authors: Samson
authors: G
authors: G
authors: Tallini
authors: H
authors: H
authors: Van den Berghe
authors: R
authors: R
authors: Vanni
authors: H
authors: H
authors: Willén
mesh_terms: D000293:Adolescent; D000328:Adult; D017824:Bone Cysts, Aneurysmal / Q000235:genetics* / Q000473:pathology*; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology*; D002869:Chromosome Aberrations; D002885:Chromosomes, Human, Pair 16; D002886:Chromosomes, Human, Pair 17; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged