CYP2D6 phenotypes among Malays in Malaysia.
BACKGROUND
Although they originated from China, Malays have undergone a lot of intermarriages. A study suggested that CYP2D6 poor metabolism (PM) phenotype was more common in Malays compared to Chinese. CYP2D6 is highly polymorphic and is involved in the metabolism of many drugs and has been implicated in some environmentally-induced diseases. It is therefore useful to further study this polymorphism in Malays.


OBJECTIVE
To study debrisoquine metabolism phenotypes in healthy Malay volunteers.


METHODS
We administered debrisoquine to 51 Malays and used HPLC to measure urinary debrisoquine and 4-hydroxy debrisoquine to calculate debrisoquine metabolic ratios (MR).


RESULTS
Debrisoquine MR varied widely and with probit analysis we were able to identify population subsets. Although the frequency distribution for the MR showed a right shift, the shift was less than that reported for the Chinese population. We also found 2 poor metabolizers and one ultra rapid metaboliser in the population.


CONCLUSIONS
The genetic polymorphism of debrisoquine in Malays differs from that in the Chinese. Both their PM prevalence and their MR distribution suggest that they are intermediate between Europeans and Chinese in relation to this polymorphism. Studies to compare CYP2D6 genotypes between them and related races would be useful to further define these differences.
Ismail
R
R
Department of Pharmacology, Universiti Sains Malaysia, 16150 Kota Bharu, Kelantan, Malaysia. isrusli@kb.usm.my
Hussein
A
A
Teh
L K
LK
Nizam Isa
M
M
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003647:Debrisoquin / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008296:Malaysia / Q000208:ethnology; D010084:Oxidation-Reduction; D010641:Phenotype; D011110:Polymorphism, Genetic
C012359:4-hydroxydebrisoquin; D019389:Cytochrome P-450 CYP2D6; D003647:Debrisoquin