Cardioactive terpenoids and a new rearranged diterpene from Salvia syriaca.
From the roots of Salvia syriaca L., in addition to known terpenoids, a new rearranged diterpene, named salvisyrianone, was isolated. The structure of the new compound was assigned from spectral data. The crude extract and the single compounds were tested for cardiovascular parameters using Wistar Albino rats. Antihypertensive activity was established in the crude extract of the roots as well as in two compounds, ferruginol and 3 beta-hydroxystigmast-5-en-7-one.
Ulubelen
A
A
University of Istanbul, Faculty of Pharmacy, Department of Chemistry, Turkey.
Oksüz
S
S
Kolak
U
U
Birman
H
H
Voelter
W
W
D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000959:Antihypertensive Agents; D004224:Diterpenes; D013729:Terpenes; C418724:salvisyrianone