title: Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium.
abstract: A series of polyacetylenes, falcarinone, panaxynol, falcarindiol, panaxydol, and panaxytriol, were isolated from Saposhnikovia divaricata (Turcz.) Schischk and Panax quinquefolium L. These polyacetylenes were identified as active principles on the inhibition of nitrite production by inducible nitric oxide synthase (iNOS). Treatment with 10 microM of panaxynol, falcarindiol, panaxydol and panaxytriol decreased the LPS/IFN-gamma-stimulated accumulation of nitrite by 71.92 +/- 3.07, 69.95 +/- 3.68, 45.48 +/- 6.11 and 36.85 +/- 8.80%, respectively. The IC50 value of falcarinone, panaxynol, falcarindiol, panaxydol and panaxytriol was > 20, 2.23, 1.98, 6.58 and 9.85 microM, respectively.
authors: C N
authors: CN
authors: Wang
authors: Y J
authors: YJ
authors: Shiao
authors: Y H
authors: YH
authors: Kuo
authors: C C
authors: CC
authors: Chen
authors: Y L
authors: YL
authors: Lin
mesh_terms: D019661:Apiaceae / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D014407:Tumor Cells, Cultured
chemical_list: D004791:Enzyme Inhibitors; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II