Non-aqueous capillary electrophoresis of tamoxifen and its acid hydrolysis products.
Tamoxifen and its acid hydrolysis products were separated and tentatively identified by non-aqueous capillary electrophoresis with thermooptical absorbance and electrospray ionization mass spectrometry. Acid hydrolysis is a convenient method of generating tamoxifen degradation products. The parent compound and seven hydrolysis products were separated in 9 min.
Li
X F
XF
Department of Chemistry, University of Alberta, Edmonton, Canada.
Carter
S J
SJ
Dovichi
N J
NJ
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D006868:Hydrolysis; D021241:Spectrometry, Mass, Electrospray Ionization; D013629:Tamoxifen / Q000032:analysis* / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D013629:Tamoxifen