title: Localization of a hereditary neuroblastoma predisposition gene to 16p12-p13.
abstract: BACKGROUND
  Hereditary predisposition to develop neuroblastoma segregates as an autosomal dominant Mendelian trait.
  
  
  METHODS
  We have performed linkage analysis on 10 families with neuroblastoma to localize a hereditary neuroblastoma predisposition gene (HNB1).
  
  
  RESULTS
  A single genomic interval at chromosome bands 16p12-p13 was consistent with linkage (lod = 3.46), and identification of informative recombinants defined a 25.9-cM critical region between D16S748 and D16S3068. Loss of heterozygosity was identified in 5/12 familial (42%) and 55/259 nonfamilial (21%) neuroblastomas at multiple 16p polymorphic loci. A 12.8-cM smallest region of overlap of deletions was identified within the interval defined by linkage analysis (tel-D16S764-D16S412-cen).
  
  
  CONCLUSIONS
  Taken together, these data suggest that HNB1 is located at 16p12-p13 and that inactivation of this gene may contribute to the pathogenesis of nonfamilial neuroblastomas.
authors: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA.
authors: M J
authors: MJ
authors: Weiss
authors: C
authors: C
authors: Guo
authors: S
authors: S
authors: Shusterman
authors: G
authors: G
authors: Hii
authors: T L
authors: TL
authors: Mirensky
authors: P S
authors: PS
authors: White
authors: M D
authors: MD
authors: Hogarty
authors: T R
authors: TR
authors: Rebbeck
authors: D
authors: D
authors: Teare
authors: M
authors: M
authors: Urbanek
authors: G M
authors: GM
authors: Brodeur
authors: J M
authors: JM
authors: Maris
mesh_terms: D002648:Child; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D019656:Loss of Heterozygosity; D009447:Neuroblastoma / Q000235:genetics*; D010375:Pedigree