title: Cerebrospinal fluid purine metabolite and neuron-specific enolase concentrations after febrile seizures.
abstract: If febrile seizures cause significant compromise of neuronal metabolism (whether permanent or reversible), this should be reflected in an increase in the cerebrospinal fluid concentrations of neuron-specific enolase (NSE) and/or adenosine triphosphate (ATP) breakdown products. In the present study, AMP, IMP, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine, uric acid and NSE concentrations were determined in the cerebrospinal fluid of 90 children 1 h after febrile seizure (73 simple febrile seizures (SFS); 17 complex febrile seizures (CFS)), and in a control group of 160 children. There was no statistically significant difference between the SFS group and the control group for any of the substances determined, suggesting that SFS neither significantly depletes neuronal ATP concentration, nor significantly increases NSE concentration; thus, SFS do not appear to constitute a threat to neuronal integrity. However, patients with CFS showed significantly lower IMP concentrations and significantly higher adenine concentrations than controls, and significantly higher AMP concentrations than SFS patients; these results suggest that CFS may affect energy metabolism in the brain. However, NSE concentrations were normal in the cerebrospinal fluid of both SFS and CFS patients, suggesting that neither type of seizure causes significant neuronal damage, at least early after the seizure.
authors: Department of Pediatrics, Hospital ClInico Universitario, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain.
authors: A
authors: A
authors: Rodríguez-Núñez
authors: E
authors: E
authors: Cid
authors: J
authors: J
authors: Rodríguez-García
authors: F
authors: F
authors: Camiña
authors: S
authors: S
authors: Rodríguez-Segade
authors: M
authors: M
authors: Castro-Gago
mesh_terms: D000249:Adenosine Monophosphate / Q000134:cerebrospinal fluid; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007291:Inosine Monophosphate / Q000134:cerebrospinal fluid; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid*; D011684:Purine Nucleosides / Q000134:cerebrospinal fluid*; D011685:Purine Nucleotides / Q000134:cerebrospinal fluid*; D011687:Purines / Q000134:cerebrospinal fluid*; D012016:Reference Values; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid* / Q000145:classification; D014527:Uric Acid / Q000134:cerebrospinal fluid
chemical_list: D011684:Purine Nucleosides; D011685:Purine Nucleotides; D011687:Purines; D007291:Inosine Monophosphate; D014527:Uric Acid; D000249:Adenosine Monophosphate; D010751:Phosphopyruvate Hydratase