The feline model of neuroAIDS: understanding the progression towards AIDS dementia.
Feline immunodeficiency virus (FIV) is a neurotropic lentivirus that produces a protracted state of immunodeficiency and encephalopathy in the cat. Recent evidence has shown several similarities to the natural progression of human immunodeficiency virus infection (HIV-1) associated degenerative effects on the central and peripheral nervous systems. Similar to HIV-1, FIV-induced encephalopathy neurovirulence is strain dependent, results in progressive immunodeficiency and increasing early peripheral but not brain viral load, preferentially affects the developing nervous system, produces quantifiable behavioural and neurophysiological impairment that is not directly linked to neuronal infectivity, and induces neuronal injury and loss both in vivo and in vitro. This paper highlights the cumulative scientific body of evidence supporting the use of the feline model of neuroAIDS.
Podell
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Department of Veterinary Clinical Sciences, The Ohio State University, Columbus 43210, USA. podell.1@osu.edu
March
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Buck
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Mathes
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D015526:AIDS Dementia Complex / Q000503:physiopathology*; D000818:Animals; D001921:Brain / Q000503:physiopathology; D002415:Cats; D018450:Disease Progression; D016181:Feline Acquired Immunodeficiency Syndrome / Q000503:physiopathology*; D015497:HIV-1; D006801:Humans; D016089:Immunodeficiency Virus, Feline