title: [Ultrasound-guided fine needle aspiration cytology (FNAC) of unclear  lesions in melanoma patients].
abstract: OBJECTIVE
  Fine needle aspiration cytology (FNAC) is widely used in oncology to obtain the diagnosis of unclear tumours in cancer patients. However, because the method is established only in few melanoma centers, we performed this study to evaluate ultrasound guided FNAC in routine follow-up of melanoma patients.
  
  
  METHODS
  Unclear tumours recognised during routine follow-up of melanoma patients underwent ultrasound guided fine needle aspiration with cytological examination. The results were then compared to subsequent histopathology or future clinical outcome.
  
  
  RESULTS
  275 unclear tumours received ultrasound guided fine needle aspiration with cytological examination. Sensitivity showed to be 95.6% [95% CI: 91.5-98.1], specificity was 100% [95% CI: 96.2-100.0]. The positive predictive value was 100.0% [95% CI: 97.9-100.0], the negative predictive value 92.2% [95% CI: 85.1%-96.9%]. In 89 cases lesions turned out to be cytologically benign thus diagnosis avoiding surgery. In lesions with diameters up to 10 mm sensitivity and specificity were 91.4% and 100.0%, respectively.
  
  
  CONCLUSIONS
  Ultrasound guided FNAC proved to be a minimal invasive procedure in the diagnosis of unclear tumours in the follow-up of melanoma patients. It allows definite diagnosis and avoids unnecessary diagnostic surgery.
authors: Universitätshautklinik der Charité, Humboldt Universität Berlin. christiane.voit@t-online.de
authors: C
authors: C
authors: Voit
authors: T
authors: T
authors: Mayer
authors: T
authors: T
authors: Proebstle
authors: M
authors: M
authors: Schwürzer-Voit
authors: M
authors: M
authors: Kron
authors: L
authors: L
authors: Weber
authors: W
authors: W
authors: Sterry
authors: A
authors: A
authors: Schoengen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods*; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography