Hereditary catalase deficiencies and increased risk of diabetes.
Partial or near-total lack of erythrocyte catalase activity is a rare condition, generally thought to be benign. However, little is known of the frequency of common diseases of adult onset in human beings with catalase deficiency. We report that, in a series of Hungarian patients with catalase deficiency, there is a higher frequency of diabetes than in unaffected first-degree relatives and the general Hungarian population. We speculate that quantitative deficiency of catalase might predispose to cumulative oxidant damage of pancreatic beta-cells and diabetes.
Góth
L
L
Eaton
J W
JW
D020642:Acatalasia; D000328:Adult; D002374:Catalase / Q000235:genetics; D003920:Diabetes Mellitus / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D018384:Oxidative Stress; D012307:Risk Factors
D002374:Catalase