Local anesthetic and antiarrhythmic effect of some imidazolidin-2-one derivatives.
A series of the new derivatives of imidazolidin-2-one was investigated in order to determine their local anesthetic and antiarrhythmic activity. All compounds tested showed strong local anesthetic properties and variable effects on adrenaline-, aconitine- and barium chloride- induced arrhythmia. The results suggest that the antiarrhythmic properties of these compounds is related to their local anesthetic properties.
Librowski
T
T
Department of Pharmacodynamics, Collegium Medicum Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
Filipek
B
B
Czarnecki
R
R
D000779:Anesthetics, Local / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D003315:Cornea / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D007093:Imidazoles