Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.
Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a variety of microbes, whereas TLR4 is essential for a complete response to LPSs. We report here that TLR2 transduces the response to phenol-soluble modulin, a factor secreted by Staphylococcus epidermidis. The TLR2-mediated response to this modulin was enhanced by TLR6 but inhibited by TLR1, indicating a functional interaction between these receptors. We also demonstrate that a response to phenol-soluble modulin mediated by TLR2 and TLR6 was more refractory to inhibition by TLR1 than one mediated by TLR2 alone.
Hajjar
A M
AM
Department of Immunology, University of Washington, Seattle, WA 98195, USA.
O'Mahony
D S
DS
Ozinsky
A
A
Underhill
D M
DM
Aderem
A
A
Klebanoff
S J
SJ
Wilson
C B
CB
D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002460:Cell Line; D003001:Cloning, Molecular; D029721:Drosophila Proteins; D005110:Extracellular Space / Q000276:immunology; D006801:Humans; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D010636:Phenols; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012995:Solubility; D013212:Staphylococcus epidermidis / Q000276:immunology*; D051194:Toll-Like Receptor 1; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051216:Toll-Like Receptor 6; D051193:Toll-Like Receptors; D014162:Transfection
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D010636:Phenols; D011956:Receptors, Cell Surface; C495342:TLR2 protein, human; C495345:TLR4 protein, human; C495368:TLR6 protein, human; C495369:Tlr6 protein, mouse; D051194:Toll-Like Receptor 1; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051216:Toll-Like Receptor 6; D051193:Toll-Like Receptors; C025971:staphylococcal delta toxin