Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency.
The respective contributions of pituitary and placental GH to circulating IGF-I in pregnant women have not been well established. We measured the serum concentrations of placental growth hormone (PGH) and IGF-I in a woman with pit-1 deficiency before, during and after pregnancy, resulting in the birth of a healthy child (not pit-1 deficient). Both PGH and IGF-I concentrations were below the assay detection limit before and after pregnancy. During pregnancy, PGH and IGF-I levels increased steadily; the concentrations of PGH and IGF-I in late pregnancy were comparable with levels previously measured in normal pregnancies. PGH and IGF-I concentrations were strongly correlated throughout pregnancy (r = 0.90; P = 0.002). PGH was undetectable in cord serum, whilst the IGF-I concentration was within the normal range. The findings of this case study corroborate the notion that PGH is the prime regulator of maternal serum IGF-I during pregnancy.
Verhaeghe
J
J
Department of Obstetrics & Gynaecology, Katholieke Universiteit Leuven, Belgium. johan.verhaeghe@uz.kuleuven.ac.be
Bougoussa
M
M
Van Herck
E
E
de Zegher
F
F
Hennen
G
G
Igout
A
A
D000328:Adult; D004268:DNA-Binding Proteins / Q000172:deficiency*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy; D015592:Immunoradiometric Assay; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D010907:Pituitary Hormones / Q000235:genetics*; D010926:Placental Hormones / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D013974:Thyroxine / Q000627:therapeutic use; D050817:Transcription Factor Pit-1; D014157:Transcription Factors / Q000172:deficiency*
D004268:DNA-Binding Proteins; C494187:POU1F1 protein, human; D010907:Pituitary Hormones; D010926:Placental Hormones; D050817:Transcription Factor Pit-1; D014157:Transcription Factors; D007334:Insulin-Like Growth Factor I; D013974:Thyroxine