Successful bone marrow transplantation in a patient with Schimke immuno-osseous dysplasia.
Early death in Schimke immuno-osseous dysplasia often results from renal failure and/or cell-mediated immunodeficiency. Kidney transplants have improved renal function, but effective therapy for the immunodeficiency has not yet been reported. We describe markedly improved marrow function 2 years after bone marrow transplantation in a boy with Schimke immunoosseous dysplasia.
Petty
E M
EM
Department of Internal Medicine, University of Michigan, Ann Arbor, 48109-0638, USA.
Yanik
G A
GA
Hutchinson
R J
RJ
Alter
B P
BP
Schmalstieg
F C
FC
Levine
J E
JE
Ginsburg
D
D
Robillard
J E
JE
Castle
V P
VP
D015703:Antigens, CD / Q000097:blood; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007231:Infant, Newborn; D016030:Kidney Transplantation; D008231:Lymphopenia / Q000150:complications / Q000175:diagnosis; D008297:Male; D010009:Osteochondrodysplasias / Q000150:complications / Q000235:genetics* / Q000628:therapy*; D010375:Pedigree; D051437:Renal Insufficiency / Q000150:complications / Q000601:surgery; D016559:Tacrolimus / Q000627:therapeutic use
D015703:Antigens, CD; D007166:Immunosuppressive Agents; D016559:Tacrolimus