title: A new one-Pot synthesis of alkynylphosphonates
abstract: A method for the palladium-catalyzed synthesis of alkynylphosphonates from 1,1-dibromo-1-alkenes has been developed. In general, the best catalyst system for this transformation was found to be Pd(OAc)(2), dppf, H-phosphonate, propylene oxide, DMF, 80 degrees C. The reaction appears tolerant of a range of functional groups in both the 1,1-dibromo-1-alkene and H-phosphonate coupling partners. The synthesis of a backbone-modified thymidine dimer is used to illustrate the application of this methodology in the synthesis of complex target molecules.
authors: The School of Chemistry, The University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
authors: M
authors: Lera
authors: CJ
authors: Hayes