Glucocorticoid-induced apoptosis in lymphocytes.
Although the effects of glucocorticoids on lymphocytes have been scrutinized for years, researchers have yet to determine how these hormones induce apoptosis in susceptible cells. Compelling evidence indicates that DNA binding of the GR and subsequent transcriptional regulation of specific genes is required for this process. However, it is not clear whether the activation or repression of responsive genes is essential and more importantly, which of these genes, if any, are responsible for the induction of apoptosis. This review will focus on how glucocorticoid-induced apoptosisin lymphocytes is mediated by the glucocorticoid receptor, including a discussion of GR structure, function, and recent data implicating its role in the apoptotic process.
Planey
S L
SL
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA.
Litwack
G
G
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D011965:Receptors, Glucocorticoid / Q000502:physiology; D014158:Transcription, Genetic
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid