title: The impact of increased mean airway pressure on contrast-enhanced MRI measurement of regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), regional mean transit time (rMTT), and regional cerebrovascular resistance (rCVR) in human volunteers.
abstract: Contrast-enhanced magnetic resonance imaging (MRI) measurement of cerebral perfusion is a diagnostic procedure increasingly gaining access to clinical practice not only in spontaneously breathing patients but also in mechanically ventilated patients. Effects of increased mean airway pressure on cerebral perfusion are entirely possible. Therefore, the present study used continuous positive airway pressure (CPAP) (12 cm H2O) to study the effects of increased mean airway pressure on cerebral perfusion in volunteers. CPAP significantly reduced regional cerebral blood flow (rCBF) and regional cerebral blood volume (rCBV) but increased regional mean transit time (rMTT) and regional cerebrovascular resistance (rCVR). Active vasoconstriction (e.g., arterial) and/or passive compression of capillary and/or venous vessel areas are the most likely underlying mechanisms. The number of interhemispheric differences in rCBF, rCBV, rMTT, and rCVR found at baseline rose when mean airway pressure was increased. These results, although obtained in volunteers, should be taken into consideration for the interpretation of contrast-enhanced MRI perfusion measurements in mechanically ventilated patients with an increased positive airway pressure.
authors: Department of Anesthesia and Intensive Care Medicine, University of Innsbruck, Austria. christian.kolbitsch@uibk.ac.at
authors: C
authors: C
authors: Kolbitsch
authors: I H
authors: IH
authors: Lorenz
authors: C
authors: C
authors: Hörmann
authors: M
authors: M
authors: Schocke
authors: C
authors: C
authors: Kremser
authors: F
authors: F
authors: Zschiegner
authors: S
authors: S
authors: Felber
authors: A
authors: A
authors: Benzer
mesh_terms: D000704:Analysis of Variance; D001783:Blood Flow Velocity; D001794:Blood Pressure; D001810:Blood Volume; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation; D006339:Heart Rate; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D012016:Reference Values; D012039:Regional Blood Flow; D015656:Respiratory Mechanics; D014655:Vascular Resistance
chemical_list: D010100:Oxygen