Effects of cisapride on corrected QT interval, heart rate, and rhythm in infants undergoing polysomnography.
OBJECTIVE
To evaluate the effects of cisapride, a prokinetic gastrointestinal drug, on the electrocardiographic QT interval, heart rate, and rhythm in infants during routine 8-hour polysomnography. Reported electrocardiogram (ECG) and rhythm disturbances in a small number of patients with the use of cisapride provided the impetus for this prospective study.


METHODS
Two hundred fifty-two infants born at term were enrolled. Of these, 134 were on cisapride therapy for suspected gastroesophageal reflux and 118 were not on cisapride and served as controls. Cisapride-treated and control infants were from the outset divided into 3 age groups; group 1: under 3 months of age; group 2: between 3 and 6 months of age; and group 3: >6 months of age. Continuous ECG bipolar limb lead I recording, saturation monitoring, and electroencephalography were conducted. QT intervals and heart rate were measured at hourly intervals.


RESULTS
Cisapride doses were: group 1 mean, 0.80 mg/kg/day (range: 0.38-1.55); group 2 mean, 0.80 mg/kg/day (range: 0. 23-1.38); and group 3 mean, 0.72 mg/kg/day (range: 0.32-1.41). Heart rate was higher in the younger infants, with a gradual decrease with age. No difference in heart rate was detected between the cisapride and control groups. The QTc interval in patients in group 1 was statistically longer than the controls, when applying both Bazett's and Hodges' formulae for QT correction. The other age groups did not differ. No arrhythmia or atrioventricular conduction abnormalities were observed.


CONCLUSIONS
Infants under 3 months of age on cisapride treatment had significantly longer QTc intervals (with Bazett's formula, the 98th percentile was 504 ms in the cisapride group vs 447 ms in controls). The clinical significance and risk of the increased QTc interval in these infants are unclear and need further evaluation and risk stratification. Meanwhile, cisapride should be judiciously prescribed in infants <3 months of age.
Benatar
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Department of Pediatric Cardiology, Academisch Ziekenhuis, Free University of Brussels, Brussels, Belgium.
Feenstra
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A
Decraene
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Vandenplas
Y
Y
D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D020117:Cisapride / Q000009:adverse effects*; D004562:Electrocardiography / Q000187:drug effects; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D005765:Gastrointestinal Agents / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007223:Infant; D008133:Long QT Syndrome / Q000139:chemically induced*; D017286:Polysomnography; D011446:Prospective Studies
D005765:Gastrointestinal Agents; D020117:Cisapride