title: [Incidence of acute leukemia in children in Mexico City, from 1982 to 1991].
abstract: OBJECTIVE
  To measure the incidence rate and trend of acute leukemia (AL) in political districts of Mexico City.
  
  
  METHODS
  Descriptive longitudinal study conducted at six hospitals that care for nearly 97.5% of all cancer cases among children in Mexico City. Study data were collected in 1995 and 1996, and were analyzed in 1999, at the National Medical Center "Siglo XXI" Children's Hospital, of the Mexican Institute for Social Security. Calculations of acute leukemia annual incidence rates, standardized rates, and standardized morbidity rates (SMR) with 95% confidence intervals, were obtained for each district. Morbidity trends were assessed through average change rates.
  
  
  RESULTS
  In this study we observed an increasing trend of acute lymphoblastic leukemia (ALL) incidence in five districts: Alvaro Obregon, Cuauhtemoc, Gustavo A. Madero, Iztacalco, and Venustiano Carranza. Acute myeloblastic leukemia (AML) showed no significantly statistic increase of incidence in any district. AML did show a significant SMR in Alvaro Obregon district (SMR = 2.91, 95% CI 1.63-4.80). Higher SMRs were found in the south and southwest areas of the city.
  
  
  CONCLUSIONS
  Increasing incidence of ALL was observed in five districts of Mexico City. AML incidence was the highest in Alvaro Obregon district.
authors: Unidad de Investigación Médica en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI (CMN SXXI), Instituto Mexicano del Seguro Social, (IMSS), México. arangurejm@hotmail.com
authors: J M
authors: JM
authors: Mejía-Aranguré
authors: A
authors: A
authors: Fajardo-Gutiérrez
authors: R
authors: R
authors: Bernáldez-Ríos
authors: R
authors: R
authors: Paredes-Aguilera
authors: H
authors: H
authors: Flores-Aguilar
authors: M C
authors: MC
authors: Martínez-García
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D015994:Incidence; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology*; D008137:Longitudinal Studies; D008800:Mexico / Q000453:epidemiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology*