Evidence that chlorophyllin (CHLN) may behave as an inhibitor or a promoter of radiation-induced genetic damage in somatic cells of drosophila.
Irradiation of 96h old Drosophila following a 24h pretreatment with 5% chlorophyllin (CHLN) was delayed 0-4 days. The antimutagenic effect of CHLN in somatic cells monitored by the wing spot test persisted for 3 days after completion of the pretreatment and appeared to terminate at a time corresponding to the cessation of mitotic divisions of wing anlagen cells. Within the same population of cells, CHLN demonstrated both an inhibitory effect as measured in mwh single spot classes, and contrarily, a promoting effect in the class of mwh/flr twin spots and to an extent in the class of large flr spots. The reason for the contrasting effects of CHLN remains to be determined.
Pimentel
E
E
Departamento de Genetica, Instituto Nacional de Investigaciones Nucleares, (ININ), Edo. de Mexico, Salazar, Mexico.
Cruces
M P
MP
Zimmering
S
S
D000818:Animals; D016587:Antimutagenic Agents; D002735:Chlorophyllides / Q000494:pharmacology* / Q000633:toxicity; D003433:Crosses, Genetic; D004330:Drosophila / Q000235:genetics* / Q000254:growth & development; D005260:Female; D007814:Larva / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009153:Mutagens; D014921:Wings, Animal / Q000187:drug effects / Q000528:radiation effects*
D016587:Antimutagenic Agents; D002735:Chlorophyllides; D009153:Mutagens; C007020:chlorophyllin