title: A sensitive and specific determination method for azaspiracids by liquid chromatography mass spectrometry.
abstract: A liquid chromatography/mass spectrometry (LC/MS) method was developed for the sensitive and specific determination of azaspiracid and its two analogs, the causative toxins of azaspiracid poisoning that occurred in the Netherlands and Ireland. The LC/MS method provided a detection limit of 50 pg for azaspiracid. The sensitivity was approximately 8 x 10(4) times greater than the mouse bioassay. The method was used to confirm the presence of azaspiracids in toxic mussels collected at Arranmore Island, Ireland in 1997.
authors: Department of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
authors: K
authors: K
authors: Ofuji
authors: M
authors: M
authors: Satake
authors: Y
authors: Y
authors: Oshima
authors: T
authors: T
authors: McMahon
authors: K J
authors: KJ
authors: James
authors: T
authors: T
authors: Yasumoto
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000737:chemistry*; D002853:Chromatography, Liquid / Q000379:methods*; D005517:Foodborne Diseases; D008387:Marine Toxins / Q000032:analysis* / Q000506:poisoning; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013141:Spiro Compounds / Q000032:analysis* / Q000506:poisoning; D000095702:Polyether Toxins
chemical_list: D008387:Marine Toxins; D013141:Spiro Compounds; C406592:azaspiracid; D000095702:Polyether Toxins