Interferon gamma and interleukin-2 secretion in whole blood cell cultures from small-cell lung cancer patients.
Secretion of interleukin-2 (IL-2) and interferon-gamma (IFNgamma) in whole blood cell cultures after phytohemagglutinin (PHA) and pokeweed mitogen (PWM) stimulation was evaluated in 42 small-cell lung cancer patients before treatment. Blood cultures from patients with extensive and limited disease have lower IFNgamma secretions after PWM stimulation and lower IL-2 secretions after PWM and PHA stimulation, but this was not statistically significant. IFNgamma but not IL-2 secretion was significantly higher after PWM stimulation in cultures from patients with better clinical performance status (0 + 1, WHO scale). Blood cultures from patients with tumor regression after treatment had a higher secretion of IFNgamma after PWM stimulation. In contrast, blood cultures from patients with a poor prognosis had significantly lower IL-2 and IFNgamma secretions after stimulation with PWM, and a lower IL-2 secretion after stimulation with PHA.
Szopiński
J
J
National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland. j.szopinski@igichp.edu
von Kleist
S
S
Rowińska-Zakrzewska
E
E
Panorska
A
A
Rogińska
E
E
Rogala
E
E
D000328:Adult; D000368:Aged; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000378:metabolism* / Q000401:mortality; D018450:Disease Progression; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D011379:Prognosis; D016896:Treatment Outcome
D007376:Interleukin-2; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D007371:Interferon-gamma