Chemical kindling and seizure susceptibility in morphine dependent rats.
In the present study, we investigated whether and how chronic morphine administration changes seizure susceptibility in rats. The role of morphine-dependence on the seizure susceptibility has been evaluated with models of pentylenetetrazol (PTZ)-kindling and acute convulsions induced by PTZ, N-methyl-D-aspartic acid (NMDA), picrotoxin and caffeine in adult male rats. The results showed that morphine-dependence increased seizure severity only at 1-4th PTZ injections in the kindling model. In acute convulsion tests, dependent rats demonstrated a significantly lower seizure threshold only for PTZ, while they demonstrated a significantly lower tendency to show tonic-clonic convulsions only for NMDA. It is concluded that morphine-dependence may modulate PTZ-kindling and seizure susceptibility in rats with emphasis on the role of GABA and NMDA neurotransmitter systems.
Atapour
N
N
Neuroscience Research Center, Kerman University of Medical Sciences, P.O. Box 76175-113, Kerman, Iran. atapour@yahoo.com
Kalantaripour
T P
TP
Nourpanah
M
M
Niazi
M
M
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology*; D004195:Disease Models, Animal; D004347:Drug Interactions; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009021:Morphine Dependence / Q000503:physiopathology*; D016202:N-Methylaspartate / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018079:Receptors, GABA / Q000187:drug effects / Q000378:metabolism; D018047:Receptors, Purinergic P1 / Q000187:drug effects / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced / Q000209:etiology
D002110:Caffeine; D003292:Convulsants; D018690:Excitatory Amino Acid Agonists; D018756:GABA Antagonists; D009020:Morphine; D016202:N-Methylaspartate; D010433:Pentylenetetrazole; D010852:Picrotoxin; D018079:Receptors, GABA; D018047:Receptors, Purinergic P1