JAK-mediated phosphorylation and activation of STAT signaling proteins. Analysis by phosphotyrosine blotting and EMSA.
Broughton
N
N
Imperial Cancer Research Fund, Lincolns Inn Fields, London, UK.
Burfoot
M S
MS
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D015153:Blotting, Western / Q000379:methods; D016384:Consensus Sequence; D016207:Cytokines / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D006801:Humans; D053613:Janus Kinase 1; D053616:Janus Kinase 3; D020935:MAP Kinase Signaling System / Q000187:drug effects / Q000502:physiology*; D015345:Oligonucleotide Probes; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000032:analysis*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D050794:STAT1 Transcription Factor; D050795:STAT2 Transcription Factor; D053634:TYK2 Kinase; D015534:Trans-Activators / Q000378:metabolism*
D016207:Cytokines; D004268:DNA-Binding Proteins; D015345:Oligonucleotide Probes; D011506:Proteins; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D050795:STAT2 Transcription Factor; D015534:Trans-Activators; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; C507933:JAK3 protein, human; D053613:Janus Kinase 1; D053616:Janus Kinase 3; D053634:TYK2 Kinase; C070139:TYK2 protein, human