Caveolins in cholesterol trafficking and signal transduction: implications for human disease.
Caveolins are a family of proteins that coat the cytoplasmic face of caveolae, vesicular invaginations of the plasma membrane. These proteins are central to the organization of the proteins and lipids that reside in caveolae. Caveolins transport cholesterol to and from caveolae, and they regulate the activity of signaling proteins that reside in caveolae. Through studying the genes encoding the caveolae coat proteins, we have learned much about how they perform these multiple functions.
Schlegel
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The Albert Einstein Comprehensive Cancer Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
Pestell
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Lisanti
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D000818:Animals; D001692:Biological Transport; D051242:Caveolin 1; D022461:Caveolins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D014443:Tyrosine / Q000378:metabolism
D051242:Caveolin 1; D022461:Caveolins; D014443:Tyrosine; D002784:Cholesterol