[Effect of ammonium succinate on pharmacological effects of acetylsalicylic acid].
Ammonia succinate potentiates the main pharmacological properties and reduces the toxic effects (ulcerogenic action and general toxicity) of acetylsalicylic acid. The new preparation astam, representing a combination of acetylsalicylic acid with ammonia succinate in a 2:1 ratio, is proposed. Astam exhibits antiexudative, capillary-reinforcing, antiproliferative, pain-relieving, antipyretic, antiaggregant, and antioxidant properties. In addition, the drug inhibits the development of structural-metabolic disorders in the case of chronic immune inflammation of joints and various internal organs.
Saratikov
A S
AS
Pharmacology Department, Siberian Medical University, Tomsk, Russia.
Bulatnikov
A P
AP
Vengerovskiĭ
A I
AI
Prishchep
T P
TP
Sibileva
L A
LA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000139:chemically induced; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D019802:Succinic Acid / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D023382:Toxicity Tests, Acute
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D004338:Drug Combinations; D010975:Platelet Aggregation Inhibitors; C469372:aspirin, succinic acid drug combination; D019802:Succinic Acid; D001241:Aspirin