A review of therapeutic angiogenesis and consideration of its potential applications to plastic and reconstructive surgery.
The use of exogenous agents to stimulate the growth of new blood vessels into ischaemic tissue is a potentially revolutionary therapy in a wide variety of clinical specialties. Therapeutic angiogenesis research has been mostly confined to ischaemia of the heart and the lower limb. There has been relatively little research into the potential applications of the technique to plastic, reconstructive and burns surgery. In this paper, relevant published work is reviewed and potential applications of therapeutic angiogenesis to our specialty are considered.
O'Toole
G
G
Department of Plastic and Reconstructive Surgery, St George Hospital, Kogarah, Sydney, New South Wales, Australia.
MacKenzie
D
D
Buckley
M F
MF
Lindeman
R
R
Poole
M
M
D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D016228:Endothelial Growth Factors / Q000627:therapeutic use; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D008222:Lymphokines / Q000627:therapeutic use; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D019990:Perioperative Care / Q000379:methods; D019651:Plastic Surgery Procedures / Q000379:methods*; D013524:Surgical Flaps / Q000098:blood supply; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D043925:Angiogenesis Inducing Agents; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors