title: MRI evaluation of aseptic osteonecrosis in children over the course of hyperbaric oxygen therapy.
abstract: OBJECTIVE
  The study aimed at MRI evaluation of aseptic osteonecrosis (AON) in children over the course of hyperbaric oxygen (HBO) therapy.
  
  
  METHODS
  Retrospective analysis of 72 MRI studies in 20 children presenting with AON during chemotherapy. Two groups were differentiated: Gr. I (n = 8) was treated exclusively with relief of weightbearing structures, Gr. II (n = 12) was additionally treated with HBO therapy. The MRI examinations were evaluated by a point-score system (1-6 points) by two radiologists.
  
  
  RESULTS
  Gr. II initially showed more severe findings (average score: 3.4) in comparison to Gr. I (average score: 2.65). During the follow-up time period the average scores rose to 3.2 score-points in Gr. I and 4.1 points in Gr. II. No statistically significant difference was evident between the two groups in the course of AON.
  
  
  CONCLUSIONS
  The majority of chemotherapy associated AON which initially present with advanced findings show a progression in MRI over their further course. HBO therapy in addition to the relief of affected weightbearing structures statistically shows no significant improvement in MRI morphology during the course of the treatment.
authors: Institute of Diagnostic Radiology, Heinrich-Heine University, Düsseldorf. scherera@uni-duesseldorf.de
authors: A
authors: A
authors: Scherer
authors: V
authors: V
authors: Engelbrecht
authors: B
authors: B
authors: Bernbeck
authors: P
authors: P
authors: May
authors: R
authors: R
authors: Willers
authors: U
authors: U
authors: Göbel
authors: U
authors: U
authors: Mödder
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009369:Neoplasms / Q000188:drug therapy; D010020:Osteonecrosis / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy*; D010146:Pain; D012189:Retrospective Studies; D016474:Weight-Bearing
chemical_list: D000970:Antineoplastic Agents