Brain perfusion monitoring with frequency-domain and continuous-wave near-infrared spectroscopy: a cross-correlation study in newborn piglets.
The newborn piglet brain model was used to correlate continuous-wave (CW) and frequency-domain (FD) near-infrared spectroscopy. Six ventilated and instrumented newborn piglets were subjected to a series of manipulations in blood oxygenation with the effects on brain perfusion known to be associated with brain hypoxia-ischaemia. An excellent agreement between the CW and FD was demonstrated. This agreement improved when the scattering properties (determined by the FD device) were employed to calculate the differential pathlength factor, an important step in CW data processing.
Zhang
G
G
Institute for Ultrafast Spectroscopy and Lasers and New York State Center for Advanced Technology for Ultrafast Photonic Materials and Applications Department of Electrical Engineering and Physics, The City College of the City Uni.
Katz
A
A
Alfano
R R
RR
Kofinas
A D
AD
Kofinas
D A
DA
Stubblefield
P G
PG
Rosenfeld
W
W
Beyer
D
D
Maulik
D
D
Stankovic
M R
MR
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D000860:Hypoxia; D007511:Ischemia; D008297:Male; D015233:Models, Statistical; D010100:Oxygen / Q000378:metabolism; D012119:Respiration; D013055:Spectrophotometry, Infrared / Q000379:methods*; D013223:Statistics as Topic; D013552:Swine; D013687:Telencephalon / Q000098:blood supply; D013997:Time Factors
D006454:Hemoglobins; D010100:Oxygen