title: [Light microscopic and ultrastructural features of nerve fibres in glomus tumor in two patients with long-term pain].
abstract: Morphologic features of nerve fibres in two cases of glomus tumour, localized in thigh skin of 57- and 72-year-old men are reported. In the patients, the paroxysms of severe pain occurred 10 and over 11 years respectively. Histological, immunohistochemical and ultrastructural examination revealed tumour cells with features resembling that of epithelioid smooth muscle cells of normal glomus body. In addition, NF-immunopositive nerve fibres were identified in connective stroma of the tumour. Ultrastructural examination revealed bundles of thin, nonmyelinated axons, surrounded by Schwann cell cytoplasm. The majority of axons were under 0.5 micron in diameter and contained densely packed neurofilaments, whereas only few axons of larger diameter exhibited electron-lucent axoplasm with granular and clear vesicles. The bundles of nonmyelinated nerves were observed always within spaces filled by collagen fibrils and did not show any special relationship to glomus cells.
authors: Zakładu Neuropatologii Instytutu Centrum Medycyny Doświadczalnej i Klinicznej PAN w Warszawie.
authors: A
authors: A
authors: Taraszewska
authors: H
authors: H
authors: Kroh
authors: P
authors: P
authors: Bojarski
mesh_terms: D000368:Aged; D005918:Glomus Tumor / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology* / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000150:complications* / Q000175:diagnosis*