title: Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2.
abstract: The synthesis and biological activity of a series of 2-[(4-methylthiopyridin-2-yl)methylsulfinyl]benzimidazoles are described. These compounds have potent inhibitory effects against the protein tyrosine phosphatase activity of CD45. Enzymatic analysis with several phosphatases revealed that compound 5a had high specificity for CD45 compared with serine/threonine phosphatases (PP1, PP2A), tyrosine phosphatases (LAR, PTP1B and PTP-S2) and dual phosphatase (VHR).
authors: Medical Research Laboratories, Taisho Pharmaceutical Co., Ltd, Saitama, Japan. s14795@ccm.taisho.co.jp
authors: T
authors: T
authors: Hamaguchi
authors: A
authors: A
authors: Takahashi
authors: T
authors: T
authors: Kagamizono
authors: A
authors: A
authors: Manaka
authors: M
authors: M
authors: Sato
authors: H
authors: H
authors: Osada
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017493:Leukocyte Common Antigens / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013454:Sulfoxides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C419888:2-((4-methylthiopyridin-2-yl)methylsulfinyl)benzimidazole; D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D013454:Sulfoxides; D017493:Leukocyte Common Antigens; D017027:Protein Tyrosine Phosphatases