Vertebrate development: the fast track to nodal signalling.
The transcription factors Fast-1 and Mixer are important terminal components of Smad2-mediated TGF-beta signal transduction. Recent studies demonstrate that Fast-1 and Mixer play critical roles in the formation of endoderm and dorsal mesoderm in zebrafish.
Stemple
D L
DL
Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK. dstempl@nimr.mrc.ac.uk
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051858:Forkhead Transcription Factors; D058851:GPI-Linked Proteins; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D016296:Mutagenesis; D055457:Nodal Protein; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism* / Q000502:physiology; D029867:Xenopus Proteins; D015027:Zebrafish / Q000196:embryology*; D029961:Zebrafish Proteins
D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D058851:GPI-Linked Proteins; D018398:Homeodomain Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D055457:Nodal Protein; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; C491116:foxh1 protein, zebrafish; C499590:mixl1 protein, zebrafish; C110484:tdgf1 protein, zebrafish; C096788:tdgf1.3 protein, Xenopus