Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model.
Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 x and 10 x MIC).
Cottagnoud
P
P
Department of Internal Medicine, Inselspital, Freiburgstrasse, 3010 Berne, Switzerland. pcottagn@insel.ch
Gerber
C M
CM
Acosta
F
F
Cottagnoud
M
M
Neftel
K
K
Täuber
M G
MG
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000069349:Linezolid; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*; D023303:Oxazolidinones / Q000494:pharmacology*; D010403:Penicillin Resistance; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid