Retrospective study of porcine circovirus 2 infection in Japan: seven cases in 1989.
Retrospectively, we demonstrated that seven pigs necropsied in 1989 had characteristic porcine circovirus 2 (PCV-2) lymphoid tissue lesions of severe lymphoid depletion, syncytial giant cell formation, and intracytoplasmic inclusion bodies in macrophages. Immunohistochemically, PCV-2 antigen was detected in these tissues and the distribution of positive staining corresponded to the distribution of inclusion bodies. Electron microscopy demonstrated viral particles compatible with porcine PCV-2. Therefore, the disease occurred in Japan as early as 1989.
Mori
M
M
Hokusei Livestock Hygiene Service Center, Yokkaichi, Mie, Japan.
Sato
K
K
Akachi
S
S
Asahi
S
S
Taniguchi
S
S
Narita
M
M
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D018173:Circoviridae Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D017925:Circovirus / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D007150:Immunohistochemistry / Q000662:veterinary; D007564:Japan / Q000453:epidemiology; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008854:Microscopy, Electron / Q000662:veterinary; D014066:Palatine Tonsil / Q000473:pathology / Q000821:virology; D012189:Retrospective Studies; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000473:pathology / Q000821:virology*
D000956:Antigens, Viral