The impact of cytomegalovirus serology for 7-year graft survival in cadaveric kidney transplantation--the Newcastle experience.
To analyse the contribution of cytomegalovirus (CMV) serology to long-term graft survival in cadaveric kidney transplantation, 404 transplants from a single centre were divided into four subgroups with respect to the combination of donor and recipient CMV antibody status. Graft survival was estimated according to Kaplan-Meier for 1, 3, 5 and 7 years post-transplantation. The single-centre results confirm a negative impact of CMV-positive donor organs for initial graft survival in CMV-negative recipients within the first 3 years after transplantation. However, when 5- and 7-year long-term graft survival was studied, Donor +/Recipient - pairs showed a favourable long-term result, whilst D +/R - pairs had surprisingly a poorer outcome. Therefore, the concept of avoiding transplantation in the D +/R + CMV serology group should be ignored whereas attempts could be made to improve the poor long-term outcome of D +/R + pairs or to reduce its size by organ allocation.
Gerstenkorn
C
C
Department of Surgery, The Medical School, University of Newcastle upon Tyne, UK. Clemens.Gerstenkorn@ncl.ac.uk
Balupuri
S
S
Mohamed
M A
MA
Manas
D M
DM
Ali
S
S
Kirby
J
J
Talbot
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000503:physiopathology* / Q000635:transmission*; D004739:England; D006085:Graft Survival; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000502:physiology*; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors; D017211:Treatment Failure
D000914:Antibodies, Viral