title: JC virus genotypes in France: molecular epidemiology and potential significance for progressive multifocal leukoencephalopathy.
abstract: JC virus (JCV) induces progressive multifocal leukoencephalopathy (PML), especially in human immunodeficiency virus (HIV)-infected patients. Although JCV genotypes have primarily been associated with geographic patterns, a distinctive neuropathogenicity was recently attributed to genotype 2. A multicenter study was conducted to describe the distribution of JCV genotypes in France and to investigate correlations between genotypes and PML. Genotypes were determined by sequencing 494 bp in the VP1 capsid gene. Peripheral JCV was studied in 65 urine samples from 43 HIV-infected patients and from 22 control subjects. Genotypes 1, 4, 2, and 3 were detected in 52.3%, 30.8%, 12.3%, and 4.6% of the samples, respectively. In 56 brain or cerebrospinal fluid samples, PML-associated JCV of genotypes 1, 2, 4, and 3 was found in 66%, 19.7%, 8.9%, and 5.4%, respectively. Infection with JCV genotypes 1 or 2 was correlated with PML (odds ratio, 3.29). On the other hand, infection with JCV genotype 4 could represent a lower risk for PML.
authors: Virology Laboratory, University Bordeaux 2, Bordeaux, France.
authors: V
authors: V
authors: Dubois
authors: H
authors: H
authors: Moret
authors: M E
authors: ME
authors: Lafon
authors: V
authors: V
authors: Brodard
authors: J
authors: J
authors: Icart
authors: A
authors: A
authors: Ruffault
authors: O
authors: O
authors: Guist'hau
authors: C
authors: C
authors: Buffet-Janvresse
authors: K
authors: K
authors: Abbed
authors: E
authors: E
authors: Dussaix
authors: D
authors: D
authors: Ingrand
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000821:virology; D000328:Adult; D000368:Aged; D001921:Brain / Q000821:virology; D002213:Capsid / Q000235:genetics; D036022:Capsid Proteins; D005260:Female; D005602:France / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D016867:Immunocompromised Host; D007577:JC Virus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000453:epidemiology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D017422:Sequence Analysis, DNA; D014556:Urine / Q000821:virology; D014774:Virulence
chemical_list: D036022:Capsid Proteins; C062481:VP1 protein, polyomavirus