Effects of cisapride on QTc interval in term neonates.
BACKGROUND
Cisapride administration for 48 hours has been shown to increase heart rate corrected QT (QTc) interval in preterm neonates. Accumulation of the drug because of liver enzyme immaturity has been suggested to be the reason. If this is correct, a longer survey of QTc interval should disclose an increase even in term neonates.


OBJECTIVE
A prospective survey of the effects of cisapride on QTc interval in term neonates administered cisapride.


METHODS
Neonatal Unit of the University Hospital of Dijon, France.


METHODS
QTc interval was determined just before and 48 hours, seven days, and 15 days after the start of treatment.


METHODS
Twenty one term newborn infants (mean gestational age 39.3 weeks) given the recommended dose of cisapride (0.2 mg/kg, four times a day).


RESULTS
Administration of cisapride caused a significant increase in QTc interval (p < 0. 01). The mean value increased from 0.397 before treatment to 0.418 after 48 hours, 0.431 by day 7, and 0.447 by day 15. A QTc interval exceeding 0.450 was found in six neonates: three at 48 hours, one at day 7, and two at day 15. In two infants, withdrawal of the drug was associated with normalisation of the QTc interval.


CONCLUSIONS
These results support the hypothesis of cisapride accumulation in newborns due to enzymatic immaturity and indicate that QTc interval should be monitored in neonates receiving this drug.
Semama
D S
DS
Service de Pédiatrie 2, Centre Hospitalier Universitaire, 10 Bd Maréchal de Lattre de Tassigny, 21034 Dijon Cedex, France. denis.semama@libertysurf.fr
Bernardini
S
S
Louf
S
S
Laurent-Atthalin
B
B
Gouyon
J B
JB
D000704:Analysis of Variance; D002118:Calcium / Q000097:blood; D020117:Cisapride / Q000627:therapeutic use*; D004311:Double-Blind Method; D004562:Electrocardiography; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008133:Long QT Syndrome / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D011188:Potassium / Q000097:blood; D011446:Prospective Studies; D018709:Statistics, Nonparametric
D005765:Gastrointestinal Agents; D011188:Potassium; D002118:Calcium; D020117:Cisapride