Substance-P of neural cells in human trigeminal ganglion.
Expression of substance-P in human neurons of trigeminal ganglia has been investigated by immunohistochemistry and morphometry. These neurons constituted 12.8% to 32.6% of the total neuronal population in the trigeminal ganglia. Substance-P positive granulations were concentrated around the nucleus, distributed focally in neuroplasm or dispersed over the neuroplasm. Morphometric analysis has indicated the presence of three populations of SP-positive cells: small, medium-sized and large. The results suggest a functional differentiation on the level of the first neurons of the afferent path of the stomatognathic system. Substance-P is likely to play a role in the transmission not only of nociceptive impulses but also of those involved in the mechano-functional stimulation of system activities.
Prośba-Mackiewicz
M
M
Department of Prosthetic Dentistry, Medical University of Gdańsk, Poland.
Zółtowska
A
A
Dziewiatkowski
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D048429:Cell Size; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009474:Neurons / Q000166:cytology*; D013373:Substance P / Q000032:analysis*; D012668:Trigeminal Ganglion / Q000166:cytology*
D013373:Substance P