Separation of drug effects on timing and behavioral inhibition by increased stimulus control.
Impulsive behavior may represent, in part, a failure of behavioral inhibition (the ability to delay or inhibit a response). In this study, use of a multiple signaled-unsignaled differential-reinforcement-of-low-rates (DRL) 15-s schedule allowed examination of drug effects in conditions in which level of stimulus control differed. Results showed that whereas diazepam increased premature responding during signaled and unsignaled DRL components, amphetamine and delta9-tetrahydrocannabinol increased premature responding primarily during unsignaled components when timing was necessary for efficient performance on the task. In contrast, pimozide and desipramine increased long-delay responses across both components, resulting in longer mean interresponse times. Collectively, these results suggest that the use of different levels of stimulus control may aid in separation of drug effects on timing and other behavioral processes, including behavioral inhibition.
Wiley
J L
JL
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Medical College of Virginia, Richmond 23298-0613, USA. jwiley@hsc.vcu.edu
Compton
A D
AD
Golden
K M
KM
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology; D013759:Dronabinol / Q000494:pharmacology; D006213:Hallucinogens / Q000494:pharmacology; D007175:Impulsive Behavior / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D023421:Models, Animal; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D012054:Reinforcement, Psychology; D013997:Time Factors
D014151:Anti-Anxiety Agents; D015259:Dopamine Agents; D006213:Hallucinogens; D010868:Pimozide; D013759:Dronabinol; D000661:Amphetamine; D003975:Diazepam