The role of prothrombotic mutations in patients with Buerger's disease.
Thromboangiitis obliterans (TAO), or Buerger's disease, is a segmental occlusive inflammatory disorder of the arteries and veins, and etiopathogenesis is still obscure. In the present study we investigated the prevalence of prothrombin 20210 G-->A, factor V 1691 G-->A (Factor V Leiden), and factor V 4070 A-->G (His 1299 Arg) mutations, found to be associated with increased risk for vascular thrombosis, in 36 patients with TAO. We performed a case-control study of these mutations. The odds ratio for prothrombin 20210 A allele compared with G allele was 7.98 (95% confidence intervals 2. 45-25.93). Only this prothrombotic genetic factor was associated with the risk of TAO (p=0.032). In conclusion, carrying the prothrombin 20210 G-->A may be an important prothrombotic risk factor of TAO. This genetic predisposition must be screened in these patients routinely, and clinical importance must be supported by further investigations.
Avcu
F
F
Department of Haematology, Ankara University, Ankara, Turkey.
Akar
E
E
Demirkiliç
U
U
Yilmaz
E
E
Akar
N
N
Yalçin
A
A
D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D017354:Point Mutation; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D013919:Thromboangiitis Obliterans / Q000453:epidemiology / Q000235:genetics*; D019851:Thrombophilia / Q000453:epidemiology / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin