[Experimental study of hemostimulating properties of the tablet form of recombinant human erythropoetin].
Specific biological activity of the domestic preparation of recombinant human erythropoietin (RHEPO) in an original pill form was experimentally studied in vitro and in vivo. Administration of the RHEPO parent substance at a concentration of 0.5 10 U/ml significantly accelerated the growth of erythroid colony-forming cells (CFU-E) in the culture of intact nonadherent myelokaryocytes. The erythropoiesis-stimulating properties of the new RHEPO preparation are comparable with those of the well-known injection preparations. The drug action is related to increasing the erythroid cell content in the bone marrow and the reticulocyte and erythrocyte counts in the peripheral blood.
Dygaĭ
A M
AM
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Russia.
Kolokol'tsova
T D
TD
Kostina
N E
NE
Minakova
M Iu
MIu
Nechaeva
E A
EA
Pozhen'ko
N S
NS
Sandakhchiev
L S
LS
Simanina
E V
EV
Khlusov
I A
IA
D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count; D002460:Cell Line; D003114:Colony-Forming Units Assay; D000068817:Epoetin Alfa; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000008:administration & dosage / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D012156:Reticulocytes / Q000187:drug effects; D013607:Tablets
D011994:Recombinant Proteins; D013607:Tablets; D004921:Erythropoietin; D000068817:Epoetin Alfa