Effect of low dose daily aspirin on serum urate levels and urinary excretion in patients receiving probenecid for gouty arthritis.
OBJECTIVE
To determine if low dose daily enteric coated aspirin significantly affects the therapeutic actions of probenecid with respect to serum urate levels or urinary urate excretion.


METHODS
Patients with gouty arthritis taking a stable dose of probenecid for at least 3 months were enrolled in a prospective crossover study. Twenty-four hour urinary and serum uric acid levels were measured after 14 days in patients crossed over to receive probenecid alone; probenecid and aspirin 325 mg taken concomitantly; and probenecid followed by aspirin 325 mg at 6 hours.


RESULTS
Eleven patients completed the crossover study. The addition of aspirin to a stable dose of probenecid had no significant effect upon serum urate levels or 24 h urinary urate excretion (p > 0.05, paired t test).


CONCLUSIONS
Low dose daily enteric coated aspirin does not significantly interfere with the uricosuric effects of probenecid in patients with gouty arthritis.
Harris
M
M
Department of Rheumatology and Medicine, San Antonio 78236-5300, USA. Mark.Harris@59MDW.whmc.af.mil
Bryant
L R
LR
Danaher
P
P
Alloway
J
J
D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D015210:Arthritis, Gouty / Q000188:drug therapy* / Q000378:metabolism; D001241:Aspirin / Q000008:administration & dosage* / Q000494:pharmacology; D018592:Cross-Over Studies; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011339:Probenecid / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood* / Q000652:urine; D014528:Uricosuric Agents / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014528:Uricosuric Agents; D014527:Uric Acid; D011339:Probenecid; D001241:Aspirin