Molecular biology of leukemia.
Identification and characterization of leukemia-related chromosomal translocations have had significant impact on all aspects of the management of acute leukemia, including its diagnosis, assignment of prognosis, and development of an appropriate treatment plan. Several genes are recurrent targets of chromosomal abnormalities, suggesting that they play a key role in leukemogenesis. Significant progress has been made to define potentially unifying molecular mechanisms of leukemic transformation. Hopefully, these findings will provide the basis for molecularly targeted therapies for leukemia.
Jakubowiak
A
A
Department of Medicine, Division of Hematologic Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
Cammenga
J
J
Sokolic
R
R
Alvarez
S
S
Jackson
G
G
Hedvat
C
C
Nimer
S D
SD
D005260:Female; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008967:Molecular Biology; D012680:Sensitivity and Specificity