[Phylogenetic relationship of street rabies virus strains and their antigenic reactivity with antibodies induced by vaccine strains. II. Correlation between genetic distance and antibody reactivity].
The aim of these studies was the estimation of the influence of genetic divergence of reactivity with sera of people vaccinated against rabies of Polish rabies strains. Genetic similarity between CVS strain and street rabies strains of genotype 1 is relatively high. However, CVS strain showed the highest reactivity with standard immunoglobulin and sera of antirabies vaccinated people (measured by western blot method). It was completely different from street viruses. Cluster method based on genetic and serologic features indicated high difference between CVS strain and street rabies strains belonging to genotype 1 and genotype 5. On this basis CVS strain was classified as a separate cluster. The genetic divergence of rabies strains circulating in Poland suggests the need of permanent epidemiological and virological surveillance. Strains different in their genotypic and biotypic characteristics should be estimated according to their antigenic similarity to vaccine strain. In practice neutralisation test using mono- and polyclonal sera should be performed. Strains isolated from new or atypical animal species should be studied first of all.
Sadkowska-Todys
M
M
Zakład Epidemiologii PZH w Warszawie.
D000818:Animals; D000937:Antigen-Antibody Reactions; D016000:Cluster Analysis; D005838:Genotype; D006801:Humans; D010802:Phylogeny; D011819:Rabies Vaccines / Q000276:immunology*; D012209:Rhabdoviridae / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D013045:Species Specificity
D011819:Rabies Vaccines