Effects of intra-abomasal infusion of beta-casomorphins on circulating concentrations of hyperglycaemic insulin and glucose in dairy cows.
The effects of intra-abomasal infusion of a mixture of -casomorphins on circulating concentrations of insulin and glucose prestimulated by either abomasal (experiment 1) or intravenous (experiment 2) glucose were studied using non-lactating dairy cows. In both experiments, bolus infusion of 240 mg of a mixture of three beta-casomorphins (beta-casomorphin-4-amide, -5 and -7) was given via an abomasal infusion line. The beta-casomorphins significantly lowered the responses of serum insulin to both abomasal and intravenous glucose infusions (P<0.05). However, the beta-casomorphins did not significantly affect circulating glucose concentrations. The insulinopenic action of the beta-casomorphins is consistent with the action of somatostatin-28 (SS-28) as judged from the effects of SS-28 on the insulin secretion when administered intravenously in experiment 1.
Kim
T G
TG
Hannah Research Institute, KA6 5HL, Ayr, UK.
Choung
J J
JJ
Wallace
R J
RJ
Chamberlain
D G
DG
D000595:Amino Acid Sequence; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle / Q000097:blood*; D004723:Endorphins / Q000008:administration & dosage*; D005260:Female; D006943:Hyperglycemia / Q000097:blood*; D007328:Insulin / Q000097:blood*
D001786:Blood Glucose; D004723:Endorphins; D007328:Insulin; C021968:beta-casomorphins