title: 4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain.
abstract: Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine (1) from the culture broth of a marine Micromonospora sp. (strain L-31-CLCO-002). The fermentation, structural data and cytotoxic activities of these compounds against various tumor cell lines are given.
authors: Instituto Biomar S.A., Pol. Ind., León, Spain.
authors: L M
authors: LM
authors: Hernández
authors: J A
authors: JA
authors: Blanco
authors: J P
authors: JP
authors: Baz
authors: J L
authors: JL
authors: Puentes
authors: F R
authors: FR
authors: Millán
authors: F E
authors: FE
authors: Vázquez
authors: R I
authors: RI
authors: Fernández-Chimeno
authors: D G
authors: DG
authors: Grávalos
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008847:Micromonospora / Q000737:chemistry* / Q000254:growth & development / Q000378:metabolism; D019311:Staurosporine / Q000031:analogs & derivatives; D014407:Tumor Cells, Cultured; D014871:Water Microbiology
chemical_list: C417109:4'-N-methyl-5'-hydroxystaurosporine; C417110:5'-hydroxystaurosporine; D000470:Alkaloids; D000970:Antineoplastic Agents; D002227:Carbazoles; D007211:Indoles; D019311:Staurosporine