Prognostic value of tumoral ploidy in a series of spanish patients with acute lymphoblastic leukemia.
The prognostic value of tumoral ploidy and its relation with nonrandom chromosome alterations were analyzed in 89 cases of acute lymphoblastic leukemia. Ploidy is associated with the number of nonrandom chromosome alterations and survival. The pseudodiploid and hypodiploid groups had a high incidence of nonrandom alterations and poor survival while the diploid and high hyperdiploid groups had a lower incidence of nonrandom alterations and longer survivals. The patients in the low hyperdiploid group with random alterations received the same treatment as the diploid and high hyperdiploid groups but had poor survivals. Our analysis confirms that ploidy is a very important prognostic factor and suggests that patients with low hyperdiploidy should receive intensive therapies similar to those of patients in the groups with a high number of nonrandom alterations.
Ramos
M L
ML
Servicio de Genética, Hospital 12 de Octubre (edificio Materno-Infantil), Carretera de Andalucía Km 5.400, 28041, Madrid, Spain. mlmartin@tdi.es
Palacios
J J
JJ
Fournier
B G
BG
Martínez
J L
JL
Martinez-López
J
J
Conde
M C
MC
Izquierdo
A M
AM
García
M M
MM
Miranda
E B
EB
D000293:Adolescent; D000328:Adult; D002648:Child; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D011003:Ploidies; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D013030:Spain; D016019:Survival Analysis