[Differential diagnostic considerations in CK-MB level increase].
We present two patients who were hospitalized due to thrombo-embolic disease. Both patients had an increase in total creatine kinase activity with the creatine kinase MB fraction value exceeding the total creatine kinase activity. We determined that the high values for creatine kinase MB fraction in the immunoinhibition assay were due to the existence of macro creatine kinase type I in one patient and a highly elevated creatinine kinase BB fraction in the other patient. The patient with macro CK type I had ulcerative colitis and the other patient with elevated CK BB fraction was diagnosed with prostatic carcinoma.
Z'Graggen
W J
WJ
Departement Innere Medizin, Kantonsspital Aarau.
Wehrli
C
C
Gautschi
K
K
Alex
V
V
Conen
D
D
D000368:Aged; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000201:enzymology; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000201:enzymology / Q000209:etiology
D007527:Isoenzymes; D003402:Creatine Kinase