Induction of preprotachykinin-I and neurokinin-1 by adrenocorticotropin and prolactin. Implication for neuroendocrine-immune-hematopoietic axis.
We studied the complex interactions within the neuroendocrine-immune-hematopoietic axis by determining a possible link among ACTH, PRL, PPT-I and the receptors for its peptides, NK-1 and NK-2. Indeed, ACTH and PRL induced the expression of PPT-I and NK-1 in human bone marrow stroma with no effect on NK-2. Consistent with a role for PPT-I in regulating the development of myeloid and erythroid progenitors, we found that ACTH and PRL, through NK-1 stimulated the proliferation of both types of progenitors. Induction of PPT-I was regulated at the transcriptional and post-transcriptional levels. The results showed that ACTH and PRL stimulated the proliferation of bone marrow progenitors, partly through PPT-I and NK-1 induction.
Maloof
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PB
UMDNJ-New Jersey Medical School, Department of Medicine-Hematology/Oncology, 185 South Orange Ave, MSB, Rm. E-579 Newark, NJ 07103, USA.
Joshi
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DD
Qian
J
J
Gascón
P
P
Singh
D
D
Rameshwar
P
P
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D001853:Bone Marrow / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D011388:Prolactin / Q000494:pharmacology*; D011498:Protein Precursors / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D017154:Stromal Cells / Q000378:metabolism; D015320:Tachykinins / Q000096:biosynthesis* / Q000235:genetics; D014158:Transcription, Genetic
D011498:Protein Precursors; D012333:RNA, Messenger; D015320:Tachykinins; C044206:preprotachykinin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin