Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex.
As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators.
Bence
A K
AK
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536, USA.
Rogers
D T
DT
Worthen
D R
DR
Fu
M
M
Littleton
J M
JM
Crooks
P A
PA
D000880:Anthraquinones / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D015317:Biogenic Polyamines; D016291:Dizocilpine Maleate / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism; D008024:Ligands; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
D000880:Anthraquinones; D015317:Biogenic Polyamines; D018691:Excitatory Amino Acid Antagonists; D008024:Ligands; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate