title: Well-ionization chamber response relative to NIST air-kerma strength standard for prostate brachytherapy seeds.
abstract: The response of well-ionization chambers to the emissions of 103Pd and 125I radioactive seed sources used in prostate cancer brachytherapy has been measured. Calibration factors relating chamber response (current or dial setting) to measured air-kerma strength have been determined for seeds from nine manufacturers, each with different designs. Variations in well-ionization chamber response relative to measured air-kerma strength have been observed because of differences in the emitted energy spectrum due to both the radionuclide support material (125I seeds) and the mass ratio of 103Pd to 102Pd (103Pd seeds). Obtaining accurate results from quality assurance measurements using well-ionization chambers at a therapy clinic requires knowledge of such differences in chamber response as a function of seed design.
authors: Physics Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA. michael.mitch@nist.gov
authors: M G
authors: MG
authors: Mitch
authors: B E
authors: BE
authors: Zimmerman
authors: P J
authors: PJ
authors: Lamperti
authors: S M
authors: SM
authors: Seltzer
authors: B M
authors: BM
authors: Coursey
mesh_terms: D000388:Air; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D010165:Palladium / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011785:Quality Assurance, Health Care; D011868:Radioisotopes / Q000627:therapeutic use; D011874:Radiometry / Q000295:instrumentation* / Q000592:standards; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000592:standards
chemical_list: D007457:Iodine Radioisotopes; D011868:Radioisotopes; D010165:Palladium