title: Development of an affordable diaphragmatic pump for cardiopulmonary bypass: an in vivo evaluation.
abstract: A new diaphragmatic pump (L-Y pump) and its drive unit were developed in our institute. The pump has a priming volume of 80 ml. The pump housing is 72 mm in diameter and 42 mm in height. Its total weight is 139 g. To assess and confirm the function and controllability of this pump, comparative studies of cardiopulmonary bypass (CPB) with L-Y pump (group A) and conventional roller pump (Group B) were performed using dogs. Both pumps provided pump flow of 90 to 100 ml/kg/min. The hemodynamics of both groups were stable and within the normal range. No leakage or thrombus formation was observed in the L-Y pump. All biochemistry data showed no significant differences between the 2 groups. This data demonstrated low plasma-free hemoglobin levels in the L-Y pump group; after 120 min of CPB, mean plasma free hemoglobin levels were 48.7 +/- 8.6 mg/dl in the roller pump group and 21.4 +/- 7.1 mg/dl in the L-Y pump group, and minimal hemolysis was indicated. In conclusion, this L-Y pump and its controller system might be useful for CPB in terms of its low hemolysis and good pump quality. This pump demonstrated easy manipulation, good controllability, and provided a sufficient pulsatile flow. This pump is suitable not only for CPB, but also as a long-term circulatory support system.
authors: Department of Cardiovascular Surgery and LVAD Laboratory, Guangdong Provincial Cardiovascular Institute, Guangzhou, People's Republic of China.
authors: X
authors: X
authors: Xiao
authors: R
authors: R
authors: Fan
authors: A
authors: A
authors: Cheng
authors: W
authors: W
authors: Gao
authors: Y
authors: Y
authors: Ding
authors: X
authors: X
authors: Zhang
authors: C
authors: C
authors: Ye
authors: Z
authors: Z
authors: Luo
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D003365:Costs and Cost Analysis; D004285:Dogs; D004867:Equipment Design; D006355:Heart-Lung Machine; D006400:Hematocrit; D006439:Hemodynamics / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D010107:Oxygenators, Membrane; D010976:Platelet Count; D011673:Pulsatile Flow / Q000502:physiology; D012212:Rheology; D013499:Surface Properties; D013927:Thrombosis / Q000209:etiology
chemical_list: D006454:Hemoglobins