The role of human and viral cytokines in the pathogenesis of multiple myeloma.
Multiple myeloma (MM) is characterized by the accumulation of monoclonal plasma cells, a terminally differentiated form of B lymphocyte, in the bone marrow. This disease is most often associated with bone destruction, anemia and renal failure. Besides the malignant plasma cells, it has become clear that nonmalignant cells in the bone marrow also contribute to the development of this malignancy by the release of cytokines. Further support for the importance of the supporting cells comes from our recent finding of the human herpesvirus 8 (HHV-8) in the nonmalignant bone marrow stromal cells from these patients.
Berenson
J R
JR
Division of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. berensonj@cshs.org
Sjak-Shie
N N
NN
Vescio
R A
RA
D016207:Cytokines / Q000502:physiology*; D016228:Endothelial Growth Factors / Q000502:physiology; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D008222:Lymphokines / Q000502:physiology; D009101:Multiple Myeloma / Q000209:etiology*; D013002:Somatomedins / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016207:Cytokines; D016228:Endothelial Growth Factors; D007375:Interleukin-1; D015850:Interleukin-6; D008222:Lymphokines; D013002:Somatomedins; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors