Changing pattern of antimicrobial susceptibility of organisms causing community acquired urinary tract infections.
OBJECTIVE
To assess common organisms causing Urinary Treat Infection (UTI) in this community and to see antimicrobial susceptibility pattern of these isolates.


METHODS
Prospective study on urine samples.


METHODS
Tertiary care hospital in Karachi.


METHODS
Over a period of 8 years (1990-97) 9,892 urine samples grew significant bacteriuria for various organisms. All Gram negative rods and entercocci was identified by using API 20E and API 32 strips respectively. Staphylococci were identified by catalase, coagulase and D'Nase tests. Antimicrobial sensitivity testing of all isolates was performed on Diagnostic Sensitivity Test plates by Kerby Bauer method. The discs used were ampicillin, trimethoprim-sulfamethoxazole, cefotaxime, ceftriaxone, aztreonam, ofloxacin, carbenicillin, amikacin, gentamicin, penicillin, clindamycin, methicillin, vancomycin, ceftazidime, cefuroxime, Nalidixic acid, pipemedic acid and Nitrofurantoin.


RESULTS
Our results indicate that E. coli and Klebsiella aerogenes are the most common organisms causing UTI in this community. Other organisms involved are Pseudomonas aeroginosa, Enterobacter species, Enterococcus, Proteus mirabillus, Staphylococcus aureus and Staphylococcus saprophyticus. Organisms resistant to various antimicrobial agents such as gentamicin, Amikacin, Ofloxacin, Cefotaxime and Ceftazidime are increasing.


CONCLUSIONS
In conclusion, E. coli and Klebsiella aerogenes are the most common organisms causing UTI in this community. Pattern of antibiotic susceptibility to first line antibiotics is changing. Antimicrobial susceptibility testing of all isolates is crucial for the treatment of UTI.
Farooqi
B J
BJ
Department of Microbiology, Aga Khan University Hospital, Karachi.
Shareeq
F
F
Rizvi
Q K
QK
Qureshi
H S
HS
Ashfaq
M K
MK
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D010154:Pakistan; D011446:Prospective Studies; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology*
D000900:Anti-Bacterial Agents