Calibration for nonlinear mixed effects models: an application to the withdrawal time prediction.
We propose calibration methods for nonlinear mixed effects models. Using an estimator whose asymptotic properties are known, four different statistics are used to perform the calibration. Simulations are carried out to compare the performance of these statistics. Finally, the milk discard time prediction of an antibiotic, which has motivated this study, is performed on real data.
Concordet
D
D
Ecole Nationale Vétérinaire de Toulouse, Unité Associée INRA de Physiopathologie et Toxicologie Expérimentales, 23 chemin des Capelles, F31076 Toulouse, France. d.concordet@envt.fr
Nunez
O G
OG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D019072:Antibiotic Prophylaxis / Q000662:veterinary; D001699:Biometry / Q000379:methods*; D002138:Calibration; D002417:Cattle; D004350:Drug Residues / Q000032:analysis; D005260:Female; D007700:Kinetics; D008892:Milk / Q000737:chemistry; D015233:Models, Statistical; D011237:Predictive Value of Tests
D000900:Anti-Bacterial Agents