Massive bleeding from a gastric erosion after transcatheter arterial chemoembolization for hepatocellular carcinoma in a patient with mild haemophilia A.
We observed massive bleeding from a gastric erosion following transcatheter arterial chemoembolization (TAE) in a patient with mild haemophilia A. A 78-year-old haemophiliac (factor VIII level over 60%) received TAE with farmorubicin and spongel. Haematemesis and melena with loss of consciousness occurred 3 days [corrected] after TAE, and endoscopy revealed superficial erosions with oozing. Toxic effects of the anticancer drug in conjunction with the bleeding disorder may have caused the massive bleeding. We should always consider the possibility of unexpected complications in patients with bleeding disorders; gastrointestinal bleeding can develop during treatment for liver tumours.
Toyoda
H
H
Second Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan.
Fukuda
Y
Y
Nakano
I
I
Katano
Y
Y
Ebata
M
M
Nagano
K
K
Morita
K
K
Yokozaki
S
S
Takeuchi
M
M
Hayakawa
T
T
Takamatsu
J
J
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects*; D006467:Hemophilia A / Q000150:complications*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000628:therapy*; D008297:Male; D013270:Stomach / Q000473:pathology
D000970:Antineoplastic Agents