Unique selectivity of iodohydroxylation reaction of allenyl phenyl sulfoxides in aqueous MeCN. A stereodefined synthesis of (E)-2-iodo-3-hydroxy-1-alkenyl sulfoxides
Iodohydroxylation reaction of allenyl phenyl sulfoxides with I(2) can smoothly proceed to generate (E)-2-iodo-3-hydroxy-1-alkenyl sulfoxides with excellent regio- and stereoselectivity in high or excellent yields. The configuration of E-2a was determined by the X-ray diffraction study.
Ma
S
Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P. R. China.
Wei
Q
Wang
H