Disruption of the blood-aqueous barrier following retinal laser photocoagulation and cryopexy in pigmented rabbits.
Disruption of the blood-aqueous barrier (BAB) induced by retinal photocoagulation and cryopexy in pigmented rabbits was evaluated by laser flare photometry. A significant increase in flare values after retinal photocoagulation was measured from the 1st postoperative day, with values returning to baseline levels by day 7. Cryopexy induced consistently high flare values for 14 days. Intravitreal injection of interleukin (IL) 1, IL-6 and prostaglandin (PG) E(2) induced a significant increase in flare values. Following these treatments, introduction of a PG synthetase inhibitor can partially ameliorate BAB disruption. IL-1, IL-6 and PGE(2) may be involved in BAB disruption following retinal photocoagulation and cryopexy.
Inoue
M
M
Department of Ophthalmology, Kobe University School of Medicine, Kobe, Japan.
Tsukahara
Y
Y
Shirabe
H
H
Yamamoto
M
M
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D018916:Blood-Aqueous Barrier / Q000502:physiology*; D003452:Cryosurgery / Q000009:adverse effects*; D015232:Dinoprostone / Q000008:administration & dosage / Q000493:pharmacokinetics; D015590:Fluorophotometry; D007267:Injections; D007375:Interleukin-1 / Q000008:administration & dosage / Q000493:pharmacokinetics; D015850:Interleukin-6 / Q000008:administration & dosage / Q000493:pharmacokinetics; D017075:Laser Coagulation / Q000009:adverse effects*; D011817:Rabbits; D012160:Retina / Q000378:metabolism / Q000601:surgery; D014822:Vitreous Body
D007375:Interleukin-1; D015850:Interleukin-6; D015232:Dinoprostone