title: Intrathoracic esophageal replacement with a collagen sponge--silicone double layer tube: evaluation of omental-pedicle wrapping and prolonged placement of an inner stent.
abstract: In a previous study, we replaced a 5 cm gap created in the canine intrathoracic esophagus with an artificial esophagus. However, although newly formed esophageal tissue subsequently bridged the gap, mild stenosis occurred, and this seemed to be caused by inadequate regeneration of the skeletal muscle. In the present study, we evaluated whether omental pedicle wrapping (OMPx) of the prosthesis could promote tissue regeneration and whether prolonged retention of the silicone tube within the prosthesis could prevent stenosis. A gap was created in 14 dogs, and the defect was repaired by our prosthesis. OMPx was performed in 5 of the 14 dogs (OMPx group) but not in the rest (control group). The silicone tube was retained for 4 weeks in the control group and for 8 weeks in the OMPx group. All of the dogs in the control group survived for more than 3 months, except for those that were killed. Four dogs in the OMPx group died within 3 months, one caused by perforation at 7 months. Only the thin epithelial and submucosal layer regenerated in the OMPx group. OMPx is not effective for promoting tissue regeneration, and prolonged retention of the silicone tube interrupts epithelial regeneration.
authors: Second Department of Surgery, Kagawa Medical University, Japan.
authors: Y
authors: Y
authors: Yamamoto
authors: T
authors: T
authors: Nakamura
authors: Y
authors: Y
authors: Shimizu
authors: K
authors: K
authors: Matsumoto
authors: Y
authors: Y
authors: Takimoto
authors: Y
authors: Y
authors: Liu
authors: H
authors: H
authors: Ueda
authors: T
authors: T
authors: Sekine
authors: N
authors: N
authors: Tamura
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001672:Biocompatible Materials; D003094:Collagen; D004285:Dogs; D004940:Esophageal Stenosis / Q000209:etiology / Q000517:prevention & control; D004947:Esophagus; D008422:Materials Testing; D009852:Omentum / Q000637:transplantation; D019919:Prosthesis Implantation; D012038:Regeneration; D012828:Silicones; D015607:Stents; D013524:Surgical Flaps
chemical_list: D001672:Biocompatible Materials; D012828:Silicones; D003094:Collagen