Chelating agents.
The antibacterial activity of metal ions, metal chelates, and molecules with chelating ability for polyvalent cations have been evaluated. The chelator N, N'-ethylenebis[2-(2-hydroxyphenyl)-glycine] (EHPG) exerted moderate-to-good activity against isolates of pathogenic bacteria and fungi. Other chelating agents such as ethylenediamine-tetraacetic acid (EDTA) and diethylene-triamine-pentaacetic acid (DTPA) revealed weak-to-moderate activity. Metal chelation of ligands reduced the activity of EDTA and DTPA.
Bergan
T
T
Institute of Microbiology, University of Oslo and Rikshospitalet (National Hospital), Oslo, Norway.
Klaveness
J
J
Aasen
A J
AJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002473:Cell Wall / Q000187:drug effects; D002614:Chelating Agents / Q000494:pharmacology*; D004492:Edetic Acid / Q000494:pharmacology*; D005029:Ethylenediamines / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D004369:Pentetic Acid / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002614:Chelating Agents; D005029:Ethylenediamines; C011813:ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid); D004369:Pentetic Acid; D004492:Edetic Acid