title: A comparison of myocardial beta-adrenoreceptor density and ligand binding affinity among selected teleost fishes.
abstract: This study quantified the cell surface beta-adrenoreceptor density and ligand binding affinity in the ventricular tissue of seven teleost species; skipjack tuna (Katsowonus pelamis), yellowfin tuna (Thunnus albacares), Pacific mackerel (Scomber japonicus), mahimahi (dolphin fish; Coryphaena hippurus), sockeye salmon (Oncorhynchus nerka), rainbow trout (Oncorhynchus mykiss) and an Antarctic nototheniid (Trematomus bernacchii). Beta-Adrenoreceptor density varied by almost fourfold among these species, being highest for the athletic fish: sockeye salmon among the salmonids and skipjack tuna among the scombrids. Beta-Adrenoreceptor density was lowest for the Antarctic icefish. Beta-Adrenoreceptor binding affinity varied by almost threefold. We conclude that there is a significant species-specific variability in myocardial beta-adrenoreceptor density and binding affinity and these interspecific differences cannot be attributed to temperature even though intraspecifically cold temperature can stimulate an increase in myocardial beta-adrenoreceptor density. Instead, we suggest that interspecifically myocardial beta-adrenoreceptor density is highest in fish that inhabit tropical water.
authors: Zoophysiology Department, University of Goteborg, Sweden.
authors: H I
authors: HI
authors: Olsson
authors: N
authors: N
authors: Yee
authors: H A
authors: HA
authors: Shiels
authors: C
authors: C
authors: Brauner
authors: A P
authors: AP
authors: Farrell
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D005399:Fishes / Q000378:metabolism*; D008024:Ligands; D009206:Myocardium / Q000378:metabolism*; D017686:Oncorhynchus mykiss; D010473:Perciformes; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012474:Salmon; D014413:Tuna
chemical_list: D008024:Ligands; D011943:Receptors, Adrenergic, beta