Acute myeloid leukaemia with giant granules: association with t(10; 11)(p13; q14) and disseminated intravascular coagulation.
A 16-year-old Chinese girl presented with AML-M5a. A bone marrow examination showed that the myeloblasts which were overwhelming the marrow contained giant granules (pseudo-Chediak-Higashi anomaly). Her karyotype showed a rare translocation t(10; 11)(p13; q14). Molecular delineation of the translocation breakpoints was not possible. Nonetheless, this case further demonstrates the morphological and phenotypic heterogeneity of acute leukaemia with this translocation. In this girl it was associated with disseminated intravascular coagulation.
Ma
S K
SK
Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong. eskma@hkucc.hku.hk
Yip
S F
SF
Wan
T S
TS
Shek
T W
TW
Ching
L M
LM
Yeung
Y M
YM
D000293:Adolescent; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D003594:Cytoplasmic Granules / Q000473:pathology* / Q000648:ultrastructure; D004211:Disseminated Intravascular Coagulation / Q000473:pathology; D005260:Female; D006801:Humans; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics / Q000473:pathology*; D008854:Microscopy, Electron; D014178:Translocation, Genetic