Influence of hydrogel bases on liberation rate and structural viscosity of potential drug XX Z.
Influences of cellulose derivatives (with and without additives of humectants) on two parameters, namely the liberation of the potential local anaesthetic XX Z and the structural viscosity of preparations were compared. The aim was to select a suitable base for topic application of the substance XX Z, chemically pyrrolidinoethylester of 3-heptyloxyphenylcarbamic acid. The rate of release of the substance XX Z from 2.5% methylcellulose base was higher then from 2% hydroxyethylcellulose base, and in both cases it was reduced after addition of humectants. It is concluded that among bases with additives of humectants is, for topic applications, more suitable the hydroxyethylcellulose base then methylcellulose base.
Vitková
Z
Z
Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, 10 Odbojárov Str., 832 32 Bratislava, Slovak.
Gardavská
K
K
Cizmárik
J
J
Rak
J
J
D000779:Anesthetics, Local / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry; D020100:Hydrogels; D007700:Kinetics; D008747:Methylcellulose; D010592:Pharmaceutic Aids; D048448:Phenylcarbamates; D014783:Viscosity
D000779:Anesthetics, Local; D002219:Carbamates; D020100:Hydrogels; D010592:Pharmaceutic Aids; D048448:Phenylcarbamates; C103106:drug XX Z; D008747:Methylcellulose