title: Enzyme-catalyzed asymmetric deacylation for the preparation of lasofoxifene (CP-336156), a selective estrogen receptor modulator.
abstract: [structure] selective estrogen receptor modulator (SERM), Lasofoxifene (CP-336156), was prepared by an enzyme-catalyzed asymmetric deacylation with high optical purity and excellent yield even though the hydrolytic site is remote from the chiral centers.
authors: Pfizer Central Research, Eastern Point Road, Groton, Connecticut 06340, USA.
authors: X
authors: X
authors: Yang
authors: A R
authors: AR
authors: Reinhold
authors: R L
authors: RL
authors: Rosati
authors: K K
authors: KK
authors: Liu
mesh_terms: D002384:Catalysis; D003640:Dealkylation; D006868:Hydrolysis; D011759:Pyrrolidines / Q000138:chemical synthesis*; D020845:Selective Estrogen Receptor Modulators / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis*; D014961:X-Ray Diffraction
chemical_list: D011759:Pyrrolidines; D020845:Selective Estrogen Receptor Modulators; D013764:Tetrahydronaphthalenes; C111332:Lasofoxifene