title: US-guided transthoracic cutting biopsy for peripheral thoracic lesions less than 3 cm in diameter.
abstract: OBJECTIVE
  To evaluate the safety and accuracy of ultrasonography (US)-guided transthoracic cutting biopsy for diagnosing peripheral thoracic lesions (<3 cm).
  
  
  METHODS
  Fifty consecutive patients with peripheral thoracic lesions less than 3 cm in diameter underwent US-guided percutaneous transthoracic cutting biopsy with a modified technique. Fifty lesions (43 parenchymal lung, two pleural, two chest wall, and three anterior mediastinal lesions) were sampled for biopsy. The final diagnosis was based on histopathologic analysis of surgical specimens (n = 18) or clinical follow-up (n = 32).
  
  
  RESULTS
  The histology recovery rate was 98% (49 lesions), and the correct diagnosis was obtained in 48 lesions (96%). Twenty-four (48%) lesions were malignant, and 26 (52%) were benign. The diagnostic accuracy for malignant lesions was 92% (22 of 24 lesions). A specific benign diagnosis was made in 17 (65%) of the 26 benign lesions, and the negative predictive value for malignancy was 93% (26 of 28 lesions). Only two patients (4%) developed postbiopsy pneumothorax, and three (6%) developed postbiopsy hemoptysis. Biopsy helped prevent surgery or thoracoscopy in 32 patients (64%): 18 patients with benign disease and 14 with multiple metastases or inoperable cancer.
  
  
  CONCLUSIONS
  US-guided transthoracic cutting biopsy appears to be a safe and effective method for diagnosing peripheral thoracic lesions less than 3 cm in diameter. The high diagnostic accuracy for benign lesions and metastatic lung cancer can help prevent surgery in many cases.
authors: Far Eastern Memorial Hospital and College of Medicine, National Taiwan University, Taipei 100, Taiwan.
authors: W Y
authors: WY
authors: Liao
authors: M Z
authors: MZ
authors: Chen
authors: Y L
authors: YL
authors: Chang
authors: H D
authors: HD
authors: Wu
authors: C J
authors: CJ
authors: Yu
authors: P H
authors: PH
authors: Kuo
authors: P C
authors: PC
authors: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods*; D002648:Child; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D018084:Ultrasonography, Interventional / Q000009:adverse effects