Zaltoprofen prevents carbon tetrachloride-induced reduction of body weight in rats.
Previously we reported carbon tetrachloride-induced body weight loss in rats as a new model of wasting disorders. The oral administration of a low dose of carbon tetrachloride to rats reduced the body weight and food intake at 24 h with a minimal effect on plasma alanine aminotransferase activity. Tumor necrosis factor-alpha, and cyclooxygenase-1 and -2 mRNA expression in the brain was not affected by carbon tetrachloride. Zaltoprofen, which is a non-steroidal anti-inflammatory drug, prevented the carbon tetrachloride-induced body weight decrease, without preventing the carbon tetrachloride-induced loss of food intake. The present results suggest the possible application of this drug for the treatment of wasting disorders.
Okamoto
T
T
Research Laboratories, Nippon Chemiphar Co., Ltd, Misato, Saitama 341-0005, Japan.
Masuda
Y
Y
Kawasaki
T
T
Okabe
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005508:Food Deprivation; D005786:Gene Expression Regulation / Q000187:drug effects; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D008565:Membrane Proteins; D011422:Propionates / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D015431:Weight Loss / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D007527:Isoenzymes; D008565:Membrane Proteins; D011422:Propionates; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; C043940:pyranoprofen; D002251:Carbon Tetrachloride; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C496513:Ptgs1 protein, rat