title: Cognitive consequences and central nervous system injury following treatment for childhood leukemia.
abstract: OBJECTIVE
  To determine the relationship between membrane damage and intellectual and academic abilities in children with acute lymphoblastic leukemia (ALL) and pilot test a math intervention for children with ALL who were affected.
  
  
  METHODS
  Research studies and review articles.
  
  
  CONCLUSIONS
  Despite the prophylactic central nervous system (CNS) treatment for long-term disease-free survival, many children with ALL subsequently experience declines in intellectual and academic skills.
  
  
  CONCLUSIONS
  Improving academic abilities in children who have received CNS treatment is of high priority and may have longlasting implications on quality of life.
authors: Division of Nursing Practice, College of Nursing, University of Arizona, Tucson 85721-0203, USA.
authors: I M
authors: IM
authors: Moore
authors: K A
authors: KA
authors: Espy
authors: P
authors: P
authors: Kaufmann
authors: J
authors: J
authors: Kramer
authors: K
authors: K
authors: Kaemingk
authors: P
authors: P
authors: Miketova
authors: N
authors: N
authors: Mollova
authors: M
authors: M
authors: Kaspar
authors: A
authors: A
authors: Pasvogel
authors: K
authors: K
authors: Schram
authors: W
authors: W
authors: Wara
authors: J
authors: J
authors: Hutter
authors: K
authors: K
authors: Matthay
mesh_terms: D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000528:radiation effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002648:Child; D003072:Cognition Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D010743:Phospholipids / Q000134:cerebrospinal fluid*; D010865:Pilot Projects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000532:radiotherapy
chemical_list: D000970:Antineoplastic Agents; D010743:Phospholipids