Genetic predictors of plasma lipid response to diet intervention.
There is a growing interest in determining the genetic predictors of plasma lipid response to diet intervention. Several candidate gene loci, namely, apolipoprotein (APO) A1, APOA4, APOC3, APOB, APOE, CETP, LPL, and FABP2, have been shown to explain a significant, but still rather small, proportion of the interindividual variability in dietary response. Other gene loci code for products that play a relevant role in lipoprotein metabolism and are prime candidates for future studies (ie, CYP7). Future progress in this complex area will come from experiments carried out using animal models and from carefully controlled dietary protocols in humans.
Ordovas
J M
JM
Lipid Metabolism Laboratory, JM-USDA-Human Nutrition Research Center on Aging at Tufts University, Department of Medicine, New England Medical Center, Boston, MA, USA.
Galluzzi
J R
JR
D001053:Apolipoproteins / Q000235:genetics*; D001161:Arteriosclerosis / Q000209:etiology / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics / Q000494:pharmacology; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics / Q000378:metabolism; D004032:Diet; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D020022:Genetic Predisposition to Disease; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins
D001053:Apolipoproteins; D002352:Carrier Proteins; D004041:Dietary Fats; C493404:FABP2 protein, human; C107608:FABP7 protein, human; C493405:Fabp2 protein, mouse; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D008055:Lipids; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D002790:Cholesterol 7-alpha-Hydroxylase