title: Effects of FKBP-12 ligands following tibial nerve injury in rats.
abstract: The neuroregenerative properties of FK506, an FKBP-12 ligand that inhibits calcineurin, and V-10,367, an FKBP-12 ligand that does not inhibit calcineurin, were evaluated in crush and transection models. Rats were randomly assigned to one of seven groups, including untreated controls and FK506- or V-10,367-treated experimental groups. Following crush or transection nerve injury, animals were assessed with walking tracks, and histomorphometry. FK506-treated animals demonstrated significant functional recovery 11 days following crush and 18 days following transection injury. In untreated and V-10,367 treated animals, nerves recovered 13 days following crush injury, but did not improve significantly prior to sacrifice at 28 days in animals sustaining a transection injury. No statistically significant differences in histomorphometric parameters were identified between any of the groups. The study confirms that FK506 accelerates recovery from tibial nerve injury.
authors: Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors: D B
authors: DB
authors: Becker
authors: J N
authors: JN
authors: Jensen
authors: T M
authors: TM
authors: Myckatyn
authors: V B
authors: VB
authors: Doolabh
authors: D A
authors: DA
authors: Hunter
authors: S E
authors: SE
authors: Mackinnon
mesh_terms: D000818:Animals; D009416:Nerve Regeneration / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D016559:Tacrolimus / Q000494:pharmacology*; D022061:Tacrolimus Binding Protein 1A / Q000037:antagonists & inhibitors*; D013979:Tibial Nerve / Q000293:injuries*
chemical_list: D018696:Neuroprotective Agents; D011725:Pyridines; C108850:V 10367; D022061:Tacrolimus Binding Protein 1A; D016559:Tacrolimus