Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor.
In recent years, substantial progress has been made towards understanding the molecular basis for CD8 binding to class I MHC and the coreceptor's role in cytotoxic T-cell activation. Here, we review the structural, mechanistic and functional studies that point to a model of coordination of T-cell receptor and CD8 signaling that might provide the key to cytotoxic T-cell activation.
Gao
G F
GF
Dept. of Molecular and Cellular Biology, 7 Divinity Avenue, Cambridge, Harvard University, Massachusetts, MA 02138, USA. ggao@crystal.harvard.edu
Jakobsen
B K
BK
D000818:Animals; D016827:CD8 Antigens / Q000737:chemistry / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D008958:Models, Molecular; D011110:Polymorphism, Genetic; D011485:Protein Binding; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012995:Solubility; D013329:Structure-Activity Relationship; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism
D016827:CD8 Antigens; D015395:Histocompatibility Antigens Class I; D020033:Protein Isoforms; D011948:Receptors, Antigen, T-Cell