title: Candida-specific systemic cell-mediated immune reactivities in human immunodeficiency virus-positive persons with mucosal candidiasis.
abstract: Oropharyngeal candidiasis (OPC), as opposed to vulvovaginal candidiasis (VVC), is a common opportunistic infection in human immunodeficiency virus (HIV)-positive persons that correlates with reduced CD4 T cell counts. Although cell-mediated immunity (CMI) by CD4 Th1-type cells is considered to be the predominant host defense against mucosal candidiasis, the immune factors associated with susceptibility to OPC in HIV-positive persons are not well understood. This study investigated Candida-specific systemic CMI in HIV-positive persons with OPC and/or VVC. Reductions in delayed skin test reactivity to Candida antigen were observed in HIV-positive persons with CD4 cell counts <200 cells/microL, irrespective of the presence of mucosal infection. Likewise, despite the correlate of OPC with reduced CD4 cell counts in HIV-positive persons, differences in Candida-specific peripheral blood mononuclear cell proliferation and Th1/Th2 cytokine production between HIV-positive and HIV-negative persons were not consistent in a manner to suggest that deficiencies in Candida-specific systemic CMI account solely for the susceptibility to OPC.
authors: Department of General Dentistry, Louisiana State University School of Dentistry, New Orleans, LA, USA.
authors: J E
authors: JE
authors: Leigh
authors: M
authors: M
authors: Barousse
authors: R K
authors: RK
authors: Swoboda
authors: T
authors: T
authors: Myers
authors: S
authors: S
authors: Hager
authors: N A
authors: NA
authors: Wolf
authors: J L
authors: JL
authors: Cutright
authors: J
authors: J
authors: Thompson
authors: J D
authors: JD
authors: Sobel
authors: P L
authors: PL
authors: Fidel
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology* / Q000382:microbiology; D018791:CD4 Lymphocyte Count; D002175:Candida / Q000276:immunology*; D002180:Candidiasis, Oral / Q000276:immunology* / Q000382:microbiology; D002181:Candidiasis, Vulvovaginal / Q000276:immunology / Q000382:microbiology; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007111:Immunity, Cellular; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D012882:Skin Tests; D013045:Species Specificity; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: D016207:Cytokines