Ureteral obstruction after ureteroneocystostomy in dogs assessed by technetium TC 99m diethylenetriamine pentaacetic acid (DTPA) scintigraphy.
OBJECTIVE
To use technetium Tc 99m diethylenetriamine pentaacetic acid (99mTc-DTPA) renal scintigraphy to monitor ureteral obstruction after ureteroneocystostomy in a canine model of partial ureteral obstruction.


METHODS
Experimental study.


METHODS
Eight normal adult dogs.


METHODS
Partial ureteral obstruction was created in 8 dogs by incomplete ligation of the terminal right ureter. Two weeks later, ureteroneocystostomy was performed in 7 dogs with unilateral partial ureteral obstruction and in 1 dog that had developed bilateral partial ureteral obstruction. 99mTc-DTPA scintigraphy was performed intermittently for 2 weeks after ureteroneocystostomy. Renal transit time of each kidney, as assessed by the time to maximal uptake (time of peak), and glomerular filtration rate, as assessed by percentage of kidney uptake of the radiopharmaceutical between 1 and 3 minutes, were estimated. Comparison between affected and nonaffected kidneys was performed with the Wilcoxon rank sum test.


RESULTS
Unilateral partial ureteral obstruction was induced successfully in 7 dogs. In 1 dog, bilateral partial obstruction was induced inadvertently. After ureteroneocystostomy, percentage of kidney uptake of 99mTc-DTPA was low in 4 affected kidneys. The uptake returned to within normal limits in 2 of the kidneys during the observation period. The time activity curve had a more rounded appearance or was increasing continuously for all affected kidneys. A significant increase in renal transit time was observed 2 and 4 days after ureteroneocystostomy. Transit time progressively returned to normal by 4 to 11 days for all affected kidneys except 1.


CONCLUSIONS
Ureteroneocystostomy resulted in persistent partial ureteral obstruction for 4 to 11 days as determined by 99mTc-DTPA scintigraphy.


CONCLUSIONS
99mTc-DTPA scintigraphy may be a useful procedure for monitoring renal function and ureteral obstruction after ureteroneocystostomy. Persistent partial ureteral obstruction may be seen 1 to 2 weeks after ureteral reimplantation in dogs with previously existing dilated ureters.
Barthez
P Y
PY
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, USA.
Smeak
D D
DD
Wisner
E R
ER
DiBartola
S P
SP
Chew
D J
DJ
D000818:Animals; D003559:Cystostomy / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000601:surgery*; D004285:Dogs; D005260:Female; D007677:Kidney Function Tests / Q000662:veterinary; D008297:Male; D011877:Radionuclide Imaging; D016284:Technetium Tc 99m Pentetate; D016896:Treatment Outcome; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging / Q000601:surgery / Q000662:veterinary*; D014519:Ureterostomy / Q000662:veterinary*
D016284:Technetium Tc 99m Pentetate