title: Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus.
abstract: [structure] The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial assay used to identify compounds that damage DNA or inhibit DNA synthesis and thereby identify potential natural product anticancer agents. Bisanthraquinones based on a 1,3,6, 8-tetrahydroxyanthraquinone-type carbon skeleton were isolated from an endophytic fungus and characterized by NMR and X-ray crystallography. Cytoskyrin A (1) is highly active in the biochemical induction assay, while the closely related cytoskyrin B (2) has no detectable activity in this assay.
authors: Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
authors: S F
authors: SF
authors: Brady
authors: M P
authors: MP
authors: Singh
authors: J E
authors: JE
authors: Janso
authors: J
authors: J
authors: Clardy
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003124:Colorimetry; D018360:Crystallography, X-Ray; D004269:DNA, Bacterial / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000737:chemistry*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D004269:DNA, Bacterial; C419462:cytoskyrin A; C419463:cytoskyrin B