title: Randomised, prospective, controlled trial comparing tropisetron with metoclopramide and placebo in controlling postoperative nausea and vomiting.
abstract: OBJECTIVE
  To compare the results of Tropisetron, Metoclopramide and placebo on postoperative nausea and vomiting in patients undergoing minilaparotomy cholecystectomy.
  
  
  METHODS
  Patients operated for minilaparotomy cholecystectomy in two private hospitals in Karachi.
  
  
  METHODS
  Fifty consecutive patients of all ages and both sex who had simple cholelithiasis and underwent minilaparotomy cholecystectomy by a single surgeon.
  
  
  METHODS
  Postoperative nausea and vomiting (PONV) at 2 hours and within 24 hours and requirement of rescue antiemetic.
  
  
  RESULTS
  Tropisetron was better than Metoclopramide and placebo in controlling postoperative nausea and vomiting.
  
  
  CONCLUSIONS
  Tropisetron when given at induction at a dose of 2 mg. intravenously prevents PONV better than Metoclopramide and placebo in 2 hours and 24 hours. It also reduces the need for rescue antiemetic significantly.
authors: Department of Surgery, Baqai Medical University, Karachi.
authors: S R
authors: SR
authors: Muhammad
authors: S Z
authors: SZ
authors: Abbas
authors: S Q
authors: SQ
authors: Abbas
mesh_terms: D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage*; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage*; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000175:diagnosis / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D000077526:Tropisetron
chemical_list: D000932:Antiemetics; D007211:Indoles; D000077526:Tropisetron; D008787:Metoclopramide