Rhesus rotavirus-based quadrivalent vaccine is efficacious despite age, socioeconomic conditions and seasonality in Venezuela.
This report describes the results of additional analyses of the trial carried out with the rhesus rotavirus-based quadrivalent vaccine in Venezuela. In the present study, we re-examined the data from this previous rotavirus vaccine trial to assess the statistical interaction between vaccine efficacy and (i) the duration of efficacy into the second year of life, (ii) socioeconomic conditions, and (iii) rotavirus seasonality. We found that among Venezuelan children, the rotavirus vaccine confers protection against severe diarrhea during the first 2 years of life independently of socioeconomic conditions and seasonality.
Egleé Pérez
M
M
Centro de Estadística y Software Matemático, CESMa, Departamento de Computo Científico y Estadística, Universidad Simón Bolívar, Caracas, Venezuela.
Glass
R
R
Alvarez
G
G
Pericchi
L R
LR
González
R
R
Kapikian
A Z
AZ
Pérez-Schael
I
I
D000367:Age Factors; D000818:Animals; D003967:Diarrhea / Q000453:epidemiology / Q000517:prevention & control; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D008253:Macaca mulatta; D008297:Male; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000517:prevention & control*; D012621:Seasons; D012959:Socioeconomic Factors; D014687:Venezuela / Q000453:epidemiology; D014765:Viral Vaccines / Q000494:pharmacology*
D014765:Viral Vaccines