[125I]-galanin binding sites in the human nodose ganglion.
The cell bodies of centrally-projecting vagal afferent neurons are contained in the inferior vagal (nodose) ganglion. Although binding sites for a number of different neuropeptides/modulators have been detected in the human nodose ganglion, the presence of galanin binding sites has not been reported. In vitro receptor autoradiography using [125I]-galanin enabled visualisation of binding sites for galanin in the human nodose ganglion. The presence of such binding sites suggests a potential role for galanin in the neuromodulation of vagal transmission in humans.
Sweerts
B W
BW
Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
Jarrott
B
B
Lawrence
A J
AJ
D000293:Adolescent; D000368:Aged; D001345:Autoradiography; D001665:Binding Sites; D019004:Galanin / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009620:Nodose Ganglion / Q000166:cytology / Q000378:metabolism*; D044088:Receptors, Galanin; D018013:Receptors, Neuropeptide / Q000032:analysis / Q000378:metabolism*
D007457:Iodine Radioisotopes; D044088:Receptors, Galanin; D018013:Receptors, Neuropeptide; D019004:Galanin