[TAME]-esterase--a new cardiovascular risk factor in smokers.
A mathematical model has been proposed to study the effect of [TAME] esterase on blood clotting time. Using this model, clotting time was found to decrease by 30% with increasing plasma [TAME] esterase activity in a group of smokers. It is hypothesized that [TAME] esterase through its effect on Hageman factor could affect clotting time. However mechanism of clotting by [TAME] esterase remains to be elucidated. It is concluded that [TAME] esterase is involved in the cascade of reactions leading to blood coagulation and increased [TAME] esterase activity could be an additional risk factor for possible cerebro-vascular accidents in smokers.
Subratty
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Departments of Health & Medical Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius.
Mooradun
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Jowaheer
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001780:Blood Coagulation Tests; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D015897:Comorbidity; D004789:Enzyme Activation; D005174:Factor XII / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood* / Q000502:physiology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D019851:Thrombophilia / Q000201:enzymology / Q000453:epidemiology / Q000209:etiology
D015415:Biomarkers; D005174:Factor XII; D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase