title: Syntheses and cytotoxic, antimicrobial, antifungal and cardiovascular activity of new quinoline derivatives
abstract: New derivatives of quinoline (CAS 91-22-5, Z-1) were synthesized and their potential therapeutical significance and structure-activity relationship were tested. The brine shrimp bioassay was carried out to study their in vitro cytotoxicity, and besides, also their antimicrobial, antifungal and cardiovascular activities were investigated. Some structures showed a high degree of activity on the isolated rabbit jejunum. Extensive spectroscopic techniques such as EIMS, FABMS, peak matching MS, UV, IR and 1H NMR were employed to confirm the structure of the synthetic products.
authors: International Center for Chemical Sciences, Husein Ebrahim Jamal (HEJ) Research Institute of Chemistry, University of Karachi, Pakistan.
authors: KM
authors: Khan
authors: ZS
authors: Saify
authors: ZA
authors: Khan
authors: M
authors: Ahmed
authors: M
authors: Saeed
authors: M
authors: Schick
authors: HJ
authors: Kohlbau
authors: W
authors: Voelter