Design and synthesis of novel [60]fullerene derivatives as potential HIV aspartic protease inhibitors.
[structure] Two water-soluble fullerene derivatives have been computer-designed and synthesized. They may exhibit interesting anti-HIV activity owing to the presence of two ammonium groups strategically located on the spheroid surface.
Marcorin
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GL
Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa, 1, 34127 Trieste, Italy.
Da Ros
T
T
Castellano
S
S
Stefancich
G
G
Bonin
I
I
Miertus
S
S
Prato
M
M
D002244:Carbon / Q000737:chemistry*; D015195:Drug Design; D037741:Fullerenes; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
D037741:Fullerenes; D017320:HIV Protease Inhibitors; D002244:Carbon; C069837:fullerene C60