Regulation of adipogenesis and energy balance by PPARgamma and PGC-1.
There has been a great deal of recent progress in our understanding of the transcriptional control of adipogenesis. Current data suggest that fat cell differentiation involves an interplay between the C/EBP family of transcription factors and PPARgamma. The thermogenic program of brown fat cells may also include a contribution from a new coactivator, PGC-1. Recent data suggests that this coactivator is responsible for activation of thermogenesis and oxidative metabolism in both brown fat and muscle. The PGC-1 dependent program includes both mitochondrial biogenesis and tissue-specific expression of uncoupling proteins.
Spiegelman
B M
BM
Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA. Bruce_Spiegelman@dfci.harvard.edu
Puigserver
P
P
Wu
Z
Z
D017667:Adipocytes / Q000166:cytology*; D000273:Adipose Tissue / Q000254:growth & development*; D002454:Cell Differentiation; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1