title: Multigenerational cortical inheritance of the Rax2 protein in orienting polarity and division in yeast.
abstract: Diploid yeast cells repeatedly polarize and bud from their poles, probably because of highly stable marks of unknown composition. Here, Rax2, a membrane protein, was shown to behave as such a mark. The Rax2 protein itself was inherited immutably at the cell cortex for multiple generations, and Rax2 was shown to have a half-life exceeding several generations. The persistent inheritance of cortical protein markers would provide a means to couple a cell's history to the future development of a precise morphogenetic form.
authors: Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
authors: T
authors: T
authors: Chen
authors: T
authors: T
authors: Hiroko
authors: A
authors: A
authors: Chaudhuri
authors: F
authors: F
authors: Inose
authors: M
authors: M
authors: Lord
authors: S
authors: S
authors: Tanaka
authors: J
authors: J
authors: Chant
authors: A
authors: A
authors: Fujita
mesh_terms: D002455:Cell Division; D016764:Cell Polarity; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009024:Morphogenesis; D009154:Mutation; D010641:Phenotype; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D015003:Yeasts / Q000166:cytology* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism
chemical_list: D005656:Fungal Proteins; D008565:Membrane Proteins; D011993:Recombinant Fusion Proteins