Measuring the water retention capacities (MRC) of different microcrystalline cellulose grades.
The ability of various types of microcrystalline cellulose (MCC) to hold water when subjected to an applied force has been assessed by a centrifuge technique. By considering the final percent of water retained after a standard centrifugation, as a function of the initial water content, a moisture retention capacity (MRC) can be determined. Statistical analysis of the results identified that it was possible to divide the nine samples of MCC into six sub-sets in terms of final moisture content retained. Those types which contained added polymer had by far the highest water level remaining. In terms of the MRC value, statistical analysis again sub-divided the celluloses into six sub-sets, although different from those for the final water content. Again those types containing added polymer gave much higher MRC values. As experiments were carried out with initial water/MCC ratios of different levels, statistical analysis of the influence of initial water content on the MRC values was undertaken with each type of MCC. The results showed a varying dependence on initial water level with the different types of cellulose. To provide a value of MRC which characterised the cellulose, the maximum value of MRC at the lowest initial water level was identified. Samples of MCC with low values of MRC have been shown previously to require less water for processing by extrusion/spheronization, while celluloses with a high MRC value appear better for the limitation of water movement during the process of extrusion/spheronization. The water retention must, however, also be considered in association with the rheological properties of the wet powder mass. Thus, while the Avicel RC591 had the highest MRC value, its rheological properties are so that the production of pellets with such a type can be less effective than with other types of MCC.
Tomer
G
G
Department of Pharmaceutics, The School of Pharmacy, University of London, 29-39 Brunswick Square, WC1N 1AX, London, UK.
Patel
H
H
Podczeck
F
F
Newton
J M
JM
D000465:Algorithms; D002482:Cellulose / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D011208:Powders; D014867:Water / Q000737:chemistry
D005079:Excipients; D011208:Powders; D014867:Water; D002482:Cellulose; C109691:microcrystalline cellulose