Intervening in atherogenesis: lessons from diabetes.
Age-related atherogenesis resembles diabetes, a model in which glucose looms as an important culprit. Within the body, the sugar becomes a glue able to harden and obstruct blood vessels while also activating such cells as macrophages and T lymphocytes. A new discovery is that large quantities of glycation endproducts may arrive preformed in foods prepared by routine cooking methods.
Vlassara
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Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, N.Y., USA.
D001161:Arteriosclerosis / Q000503:physiopathology* / Q000517:prevention & control*; D003296:Cooking; D003920:Diabetes Mellitus / Q000503:physiopathology; D004036:Diet, Atherogenic; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D005947:Glucose / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000097:blood / Q000737:chemistry; D006146:Guanidines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological
D004791:Enzyme Inhibitors; D017127:Glycation End Products, Advanced; D006146:Guanidines; D005947:Glucose; C004479:pimagedine