title: Insect metamorphosis: out with the old, in with the new.
abstract: During insect metamorphosis, the steroid hormone ecdysone activates programmed cell death of larval tissues and the further development of adult tissues. Recent studies suggest that the E93 gene is both necessary and sufficient to target tissues for ecdysone-induced apoptosis.
authors: Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA.
authors: M
authors: M
authors: Buszczak
authors: W A
authors: WA
authors: Segraves
mesh_terms: D000818:Animals; D017209:Apoptosis; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology; D004441:Ecdysterone / Q000378:metabolism / Q000494:pharmacology; D005786:Gene Expression Regulation; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D008675:Metamorphosis, Biological / Q000502:physiology*; D009479:Neuropeptides / Q000235:genetics; D010455:Peptides / Q000235:genetics; D011987:Receptors, Steroid / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: C102117:Br protein, Drosophila; C111892:DIAP2 protein, Drosophila; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C060408:Eip74EF protein, Drosophila; C095837:Eip93F protein, Drosophila; C108880:HID protein, Drosophila; D051034:Inhibitor of Apoptosis Proteins; D019476:Insect Proteins; D009479:Neuropeptides; D010455:Peptides; D011987:Receptors, Steroid; D014157:Transcription Factors; C066030:USP protein, Drosophila; C055469:ecdysone receptor; C086973:rpr protein, Drosophila; C110602:transcription factor E75, Manduca; D004441:Ecdysterone