title: Primary diffuse leptomeningeal gliomatosis simulating tuberculous meningitis.
abstract: Three patients are reported on who presented with communicating hydrocephalus due to presumed tuberculous meningitis. Subsequent clinical deterioration despite antituberculous chemotherapy prompted reassessment with FDG-PET scanning and meningeal biopsy in one case and repeat CSF cytology with special staining in the second. The third patient died and postmortem confirmed a diagnosis of primary diffuse leptomeningeal gliomatosis. In the first two patients, MRI of the entire neuraxis showed no evidence of a primary intraparenchymal tumour. These cases emphasise the need for repeated reassessment in patients with culture negative lymphocytic meningitis. In addition, this is the first report of FDG-PET scanning in leptomeningeal gliomatosis.
authors: University Department of Clinical Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK. j.rees@ion.ucl.ac.uk
authors: J H
authors: JH
authors: Rees
authors: N
authors: N
authors: Balakas
authors: A
authors: A
authors: Agathonikou
authors: S F
authors: SF
authors: Hain
authors: G
authors: G
authors: Giovanonni
authors: C P
authors: CP
authors: Panayiotopoulos
authors: M
authors: M
authors: Luxsuwong
authors: T
authors: T
authors: Revesz
mesh_terms: D000328:Adult; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon; D014390:Tuberculosis, Meningeal / Q000175:diagnosis* / Q000000981:diagnostic imaging*