title: The pivotal role of deep vein thrombophlebitis in the development of acute disseminated staphylococcal disease in children.
abstract: Deep vein thrombophlebitis (DVT) and septic pulmonary emboli (PE) are rare in children. The association of DVT and acute disseminated staphylococcal disease (DSD) during childhood has not been previously reported. We report 3 children who developed a triad of DVT, septic PE, and acute osteomyelitis with Staphylococcus aureus cultured from blood and bone. One child succumbed, while 2 survived following prolonged, morbid hospitalizations. The rapid clinical deterioration observed in these patients might be caused by the aggressiveness of staphylococcal infection combined with an ongoing showering of septic emboli from the ileo-femoral DVT. We suggest that infected DVT with septic PE had a pivotal role in the development of DSD in these children. The presence of this triad should prompt aggressive treatment with the appropriate antibiotics, anticoagulation, surgical drainage, and assisted ventilation when indicated.
authors: Department of Pediatric Surgery, Holon, Israel. fhserour@yahoo.com
authors: A
authors: A
authors: Gorenstein
authors: E
authors: E
authors: Gross
authors: S
authors: S
authors: Houri
authors: G
authors: G
authors: Gewirts
authors: S
authors: S
authors: Katz
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001769:Blood / Q000382:microbiology; D001842:Bone and Bones / Q000382:microbiology; D002648:Child; D017809:Fatal Outcome; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000382:microbiology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011030:Pneumothorax / Q000000981:diagnostic imaging / Q000209:etiology; D011859:Radiography; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013924:Thrombophlebitis / Q000150:complications*; D014463:Ultrasonography
chemical_list: D000900:Anti-Bacterial Agents