title: [Centromere separation and malignancy].
abstract: The centromeres of human chromosomes separate according to a "normal sequence" during mitosis. "Out-of-phase" separation and especially premature centromere division may lead to aneuploidy, and may be regarded as a manifestation of chromosome instability. Evaluation of these phenomena may contribute to a better understanding of predisposition to malignancy and to the possible screening of family members at high risk of cancer. For this reason, a more up-to-date and meticulous research of regulation and clinical significance of centromere separation is warranted.
authors: Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Gyermekklinika.
authors: K
authors: K
authors: Méhes
mesh_terms: D000818:Animals; D002503:Centromere / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*