title: Antimalarial preracemosols A and B, possible biogenetic precursors of racemosol from Bauhinia malabarica Roxb.
abstract: Racemosol and demethylracemosol, together with their possible biogenetic precursors, preracemosol A and preracemosol B, were isolated from the roots of Bauhinia malabarica Roxb. While only racemosol and demethylracemosol exhibited cytotoxicity against KB and BC cell lines, all four compounds exhibited moderate antimalarial activity.
authors: National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Rajdhevee, Bangkok, Thailand. prasat@biotec.or.th
authors: P
authors: P
authors: Kittakoop
authors: K
authors: K
authors: Kirtikara
authors: M
authors: M
authors: Tanticharoen
authors: Y
authors: Y
authors: Thebtaranonth
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001632:Bibenzyls / Q000737:chemistry / Q000378:metabolism*; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D019685:Rosales / Q000737:chemistry*; D013057:Spectrum Analysis; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000962:Antimalarials; D001632:Bibenzyls; D013729:Terpenes; C420864:preracemosol A; C420865:preracemosol B; C420866:racemosol