Smoking preceded pulmonary involvement in adults with Langerhans cell histiocytosis diagnosed in childhood.
Two patients with childhood Langerhans cell histiocytosis (LCH) (aged 2 and 6 y at diagnosis) in whom pulmonary involvement was diagnosed in adulthood, 23 and 12 y later, respectively, are presented. In each patient, smoking preceded the diagnosis of pulmonary involvement by 3 y, providing further evidence that smoking is a risk factor in the development of pulmonary LCH.
Bernstrand
C
C
Chilhood Cancer Research Unit, Karolinska Hospital, Stockholm, Sweden.
Cederlund
K
K
Ashtröm
L
L
Henter
J I
JI
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D013902:Radiography, Thoracic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors; D014057:Tomography, X-Ray Computed