Effects of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green in human septic shock.
OBJECTIVE
To evaluate the effect of the stable prostacyclin analogue iloprost on the plasma disappearance rate of indocyanine green (PDR) in patients with septic shock.


METHODS
A prospective clinical study in a university hospital intensive care unit.


METHODS
20 patients in septic shock. Patients received iloprost infusion (1 ng/kg per minute) for 24 h.


RESULTS
PDR was determined by a femoral arterial fiberoptic catheter before, 1, 6, and 24 h after start and 1 h after end of iloprost infusion. PDR increased significantly 24 h after start of iloprost infusion (baseline: 13.9 +/- 1.7% vs. 18.6 +/- 2.2%/min) and decreased 1 h after end of infusion (13.7 +/- 1.7%/min; p < 0.002). There was no change in pHi, cardiac index, mean arterial pressure, heart rate, central venous pressure, or intrathoracic blood volume index.


CONCLUSIONS
Administration of the stable prostacyclin analogue iloprost significantly increases PDR, indicating improvement in liver function.
Lehmann
C
C
Klinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Charité, Berlin, Germany. christian.lehmann@charite.de
Taymoorian
K
K
Wauer
H
H
Krausch
D
D
Birnbaum
J
J
Kox
W J
WJ
D000328:Adult; D000368:Aged; D004396:Coloring Agents / Q000493:pharmacokinetics*; D016903:Drug Monitoring / Q000295:instrumentation / Q000379:methods; D004395:Dye Dilution Technique / Q000295:instrumentation; D011464:Epoprostenol / Q000031:analogs & derivatives*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016285:Iloprost / Q000494:pharmacology / Q000627:therapeutic use*; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D011446:Prospective Studies; D012772:Shock, Septic / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D004396:Coloring Agents; D014665:Vasodilator Agents; D011464:Epoprostenol; D007208:Indocyanine Green; D016285:Iloprost