2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 1.
N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.
Sarshar
S
S
Ontogen Corporation, Carlsbad, CA 92009, USA. sep.sarshar@agouron.com
Zhang
C
C
Moran
E J
EJ
Krane
S
S
Rodarte
J C
JC
Benbatoul
K D
KD
Dixon
R
R
Mjalli
A M
AM
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects* / Q000502:physiology; D018432:Drug Resistance, Multiple; D007093:Imidazoles / Q000494:pharmacology*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007093:Imidazoles