Membrane targeting: what a difference a G makes.
Pleckstrin homology domains are modular domains that direct membrane targeting of their host proteins by binding to polyphosphoinositides; recent results have increased our appreciation of how some of these domains actually bind 3-phosphoinositides, and along the way thrown up some unexpected observations.
Cullen
P J
PJ
Department of Biochemistry, University of Bristol, BS8 1TD,., Bristol, UK. Pete.Cullin@bris.ac.uk
Chardin
P
P
D048868:Adaptor Proteins, Signal Transducing; D000077329:Agammaglobulinaemia Tyrosine Kinase; D001798:Blood Proteins / Q000737:chemistry* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D005227:Fatty Acids / Q000737:chemistry / Q000378:metabolism; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000378:metabolism; D005998:Glycine / Q000737:chemistry*; D008074:Lipoproteins; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010750:Phosphoproteins / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D001798:Blood Proteins; C403524:Dapp1 protein, mouse; D005227:Fatty Acids; D020690:GTPase-Activating Proteins; D008074:Lipoproteins; D018129:Phosphatidylinositol Phosphates; D010750:Phosphoproteins; D011506:Proteins; D018160:Receptors, Cytoplasmic and Nuclear; C102474:cytohesin-2; C040985:phosphatidylinositol receptors; C039077:platelet protein P47; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; D005998:Glycine