Analysis of longitudinal data from twins.
Longitudinal data from twin pairs may be used to determine how the genetic effects influencing a quantitative trait change with age. Here a model for mixed longitudinal data of Huggins and Loesch [1998] on unrelated individuals is extended to twin studies. The model is fitted using robust statistical methods and a bootstrap procedure is proposed to estimate the percentiles. The method is applied to longitudinal twin data on body mass index in male and female twin pairs aged 5-18 years.
Huggins
R M
RM
Department of Statistical Science, La Trobe University, Bundoora, Australia. r.huggins@latrobe.edu.au
Hoang
N H
NH
Loesch
D Z
DZ
D000293:Adolescent; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004777:Environment; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical; D019655:Quantitative Trait, Heritable; D014427:Twins