Systemic injection with DSP-4 decreases the clonidine hypotension in bicuculline-treated rats.
The effect of DSP-4 [N-/2-chloroethyl/-N-ethyl-2-bromobenzylamine] upon blood pressure and of clonidine hypotension before and after bicuculline treatment were studied in rats. Normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were injected with DSP-4 at the dose of 50 mg/kg i.p. twice. Clonidine was given i.p. at the dose of 10 microg/kg in SHR and 20 microg/kg in WKY at the 7th, 9th and 15th day after DSP-4 administration. Bicuculline was injected at the dose of 1mg/kg i.p. The blood pressure and clonidine hypotension appeared unaffected by DSP-4 pretreatment in WKY and SHR rats. In both rat strains the bicuculline reduced clonidine hypotension and the phenomenon was augmented after DSP-4 lesioning. The data suggest that the alterations in GABAergic and other neurotransmitter system function evoke increasing effect of bicuculline.
Gozlinska
B
B
Department of Pharmacology, Drug Institute, Warsaw, Poland.
Czyźewska-Szafran
H
H
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001596:Benzylamines / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D018756:GABA Antagonists / Q000494:pharmacology*; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D011921:Rats, Inbred WKY
D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D001596:Benzylamines; D015306:Biogenic Monoamines; D018756:GABA Antagonists; D003000:Clonidine; C012102:DSP 4; D001640:Bicuculline