[Morphological and functional changes in nasal mucosa after nCPAP therapy].
OBJECTIVE
The treatment success of nCPAP therapy (nasal continuous positive airway pressure) depends partly on the relief of symptoms and partly on long-term patient acceptance and the related avoidance of complications. Nasal complaints constitute the most frequently reported side effects and, together with problems of mask application, are among the primary factors causing an nCPAP-therapy to be prematurely discontinued.


METHODS
To assess the morphological changes of the nasal mucosa during nCPAP-therapy, we excised specimens of nasal mucosa tissue in twelve patients with obstructive sleep apnea syndrome (OSAS) both before and 3-10 months after establishing nCPAP-mask acceptance. The specimens were examined by electron microscopy.


RESULTS
In all these patients, acceptance of the CPAP mask marked the initial part of therapy. In addition, mucociliary clearance was assessed by the saccharin test before and after therapy. In all patients, the nasal epithelium underwent fundamental changes upon CPAP therapy, which became manifest as modifications in the shape of epithelial cells, conglutination and clumping of the microvilli, and the appearance of immunocompetent cells. Once patients were nCPAP mask compliant, mucociliary clearance was distinctly prolonged in all cases.


CONCLUSIONS
A successful therapeutic concept should provide normalization of room temperature and air humidity once nCPAP mask compliance has been achieved, and include regular assessment of the condition of the mucosa in the upper respiratory tract. Only by these measures can nasal complications be countered or therapy be applied at an early stage.
Constantinidis
J
J
Klinik und Poliklinik für HNO-Heilkunde, Universitätskliniken des Saarlandes, Homburg/Saar.
Knöbber
D
D
Steinhart
H
H
Kuhn
J
J
Iro
H
H
D000368:Aged; D001706:Biopsy; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008397:Masks; D008854:Microscopy, Electron; D008871:Microvilli / Q000473:pathology; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000502:physiology; D009297:Nasal Mucosa / Q000473:pathology*; D011175:Positive-Pressure Respiration / Q000295:instrumentation*; D020181:Sleep Apnea, Obstructive / Q000473:pathology* / Q000628:therapy