Platelet-derived endothelial cell growth factor in keratinizing-type squamous cell uterine cervical cancer.
The purpose of this study was to determine whether intratumor expression of platelet-derived endothelial cell growth factor (PD-ECGF) is a prognostic factor. We examined specimens from 61 cases of carcinoma of uterine cervix (Ca-Cx). Specimens were stained with periodic acid-Schiff preparation with diastase (d-PAS) and alcian blue (pH 2.5) to identify the presence of intracellular mucin. PD-ECGF expression and microvessel count (MVC) were assessed by immunohistochemical staining. Twenty specimens stained positive for mucin. MVC correlated with clinical stage (p<0.01). There was a correlation between PD-ECGF expression and survival time (p<0.05), but no correlation was seen between mucin staining positivity, MVC, and PD-ECGF expression and survival time by the Cox proportional hazard model. Intratumor PD-ECGF expression was not a prognostic factor in keratinizing-type squamous cell carcinoma of the uterine cervix.
Matsumoto
Y
Y
Department of Obstetrics and Gynecology, Osaka City University Medical School, Abeno-ku, Osaka 545-8585, Japan.
Ishiko
O
O
Deguchi
M
M
Ogita
S
S
Haba
T
T
Wakasa
K
K
D000328:Adult; D000368:Aged; D000423:Alcian Blue; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D004396:Coloring Agents; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007564:Japan / Q000453:epidemiology; D007633:Keratins / Q000032:analysis; D015993:Life Tables; D008875:Middle Aged; D009077:Mucins / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis*; D010503:Periodic Acid-Schiff Reaction; D011379:Prognosis; D016016:Proportional Hazards Models; D013194:Staining and Labeling; D016019:Survival Analysis; D013939:Thymidine Phosphorylase / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000378:metabolism / Q000401:mortality / Q000473:pathology
D004396:Coloring Agents; D009077:Mucins; D009363:Neoplasm Proteins; D007633:Keratins; D013939:Thymidine Phosphorylase; D000423:Alcian Blue