Effect of the angiotensin-converting enzyme gene deletion polymorphism on the risk of venous thromboembolism.
Allele frequencies for the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene were determined in a large case-control study of 517 unselected patients with venous thromboembolism and 478 blood donors. The D allele frequency was 0. 53 [95% confidence interval (CI) 0.50-0.56] in patients and 0.54 (95% CI 0.50-0.57) in controls, giving an odds ratio for the D allele of 0.97 (95% CI 0.81-1.16). In the same population, the odds ratio for the factor V Leiden mutation (F5G1691A) was 6.9 (95% CI 4. 0-11.9). Therefore, the ACE I/D polymorphism is not a risk factor in a representative group of unselected patients with venous thromboembolism. The possibility that the I/D polymorphism is a risk factor for venous thromboembolism specifically after hip replacement cannot be excluded.
Jackson
A
A
Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK.
Brown
K
K
Langdown
J
J
Luddington
R
R
Baglin
T
T
D019644:Arthroplasty, Replacement, Hip; D001782:Blood Donors; D016022:Case-Control Studies; D005165:Factor V; D017353:Gene Deletion; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D013923:Thromboembolism / Q000235:genetics*; D020246:Venous Thrombosis / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V; D007703:Peptidyl-Dipeptidase A