title: Fratricide among CD8(+) T lymphocytes naturally infected with human T cell lymphotropic virus type I.
abstract: Infection and gene expression by the human T lymphotropic virus type I (HTLV-I) in vivo have been thought to be confined to CD4(+) T lymphocytes. We show here that, in natural HTLV-I infection, a significant proportion of CD8(+) T lymphocytes are infected by HTLV-I. Interestingly, HTLV-I-specific but not Epstein-Barr virus-specific CD8(+) T lymphocytes were shown to be infected. Furthermore, HTLV-I protein expression in naturally infected CD8(+) T lymphocytes renders them susceptible to fratricide mediated by autologous HTLV-I-specific CD8(+) T lymphocytes. Fratricide among virus-specific CTLs could impair the immune control of HTLV-I and possibly other lymphotropic viruses.
authors: Department of Immunology, Imperial College School of Medicine, St Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom.
authors: E
authors: E
authors: Hanon
authors: J C
authors: JC
authors: Stinchcombe
authors: M
authors: M
authors: Saito
authors: B E
authors: BE
authors: Asquith
authors: G P
authors: GP
authors: Taylor
authors: Y
authors: Y
authors: Tanaka
authors: J N
authors: JN
authors: Weber
authors: G M
authors: GM
authors: Griffiths
authors: C R
authors: CR
authors: Bangham
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology*; D003602:Cytotoxicity, Immunologic; D015490:HTLV-I Infections / Q000276:immunology*; D015368:Human T-lymphotropic virus 1; D006801:Humans