Comparison of invasive and noninvasive measurements of indocyanine green plasma disappearance rate in critically ill patients with mechanical ventilation and stable hemodynamics.
OBJECTIVE
We studied the correlation between invasive (aortic fiberoptic) and noninvasive (transcutaneous sensor) measurements of indocyanine green (ICG) plasma disappearance rate (PDR) in critically ill patients.


METHODS
Prospective clinical study in a surgical intensive care unit of a university hospital.


METHODS
16 critically ill patients with adult respiratory distress syndrome (n = 8), sepsis/septic shock (n = 6), subarachnoid hemorrhage (n = 1), or severe head injury (n = 1).


RESULTS
We analyzed 16 pairs of simultaneous ICG PDR measurements. All patients were deeply sedated and mechanically ventilated. Each patient received a 4-F aortic catheter with an integrated fiberoptic and thermistor connected to a computer system for automatic calculation of invasive ICG PDR (PDRINV). An ICG sensor was also attached to the nose wing and connected to a DDG2001 analyzer for noninvasive measurement (PDRNINV). Linear regression analysis revealed PDRNINV = 0.98 PDRINV +0.11%/min (r = 0.94, p < 0.0001) with a mean bias of 0.2 +/- 2.0%/min.


CONCLUSIONS
Noninvasive measurements of ICG PDR are very highly correlated with values derived from an invasive fiberoptic-based reference technique.
Sakka
S G
SG
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Germany.
Reinhart
K
K
Meier-Hellmann
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015982:Bias; D001785:Blood Gas Monitoring, Transcutaneous / Q000295:instrumentation / Q000379:methods*; D004396:Coloring Agents / Q000493:pharmacokinetics*; D006259:Craniocerebral Trauma / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D016638:Critical Illness; D004395:Dye Dilution Technique / Q000295:instrumentation; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D016014:Linear Models; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000009:adverse effects*; D012128:Respiratory Distress Syndrome / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D018805:Sepsis / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D013345:Subarachnoid Hemorrhage / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy
D004396:Coloring Agents; D007208:Indocyanine Green