title: Gahat: a Napalese cure for urolithiasis?
abstract: OBJECTIVE
  Gahat (Vigna unguiculata) is a legume used for centuries in Nepal and Pakistan to treat the symptoms associated with urinary calculi. We prospectively evaluated the effect of Gahat consumption on 24-hour urine parameters in an attempt to assess its in vivo effect in normal volunteers.
  
  
  METHODS
  Eight non-stone-forming volunteers collected 24-hour urine specimens while on their routine diets for baseline data. Urine was analyzed for pH, volume, calcium, citrate, phosphate, sodium, magnesium, uric acid, and oxalate. The Gahat was prepared according to local custom. No additives were used to enhance flavor. The pureed mixture (8 ounces) was ingested three times daily for 2 days. Subjects were instructed to maintain their normal diet, including fluid intake and activity during the study period. Twenty-four hours after the start of Gahat intake, a second 24-hour urine collection was initiated while volunteers continued the Gahat. Results of the urine samples before and after Gahat intake were analyzed, using the paired Student t test.
  
  
  RESULTS
  There were no significant differences in urinary electrolytes between the urine samples before and after Gahat intake. Magnesium, urine volume, and uric acid differences approached clinical significance.
  
  
  CONCLUSIONS
  Gahat increased urinary magnesium through an unknown mechanism and had no effect on other routine 24-hour urine electrolytes. The increase in urinary volume is attributed to the increase in fluid consumption by the subjects. If this legume is effective in preventing or dissolving urinary calculi, it may act through mechanisms not identified in 24-hour urine electrolytes.
authors: Tripler Army Medical Center, Honolulu, Hawaii, USA.
authors: B F
authors: BF
authors: Schwartz
authors: N
authors: N
authors: Schenkman
authors: R
authors: R
authors: Nguyen
authors: M L
authors: ML
authors: Stoller
mesh_terms: D002951:Citrates / Q000652:urine; D004032:Diet; D007887:Fabaceae / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000652:urine; D008519:Medicine, Traditional; D009390:Nepal; D008517:Phytotherapy; D010946:Plants, Medicinal; D011446:Prospective Studies; D014527:Uric Acid / Q000652:urine; D014545:Urinary Calculi / Q000188:drug therapy*; D014556:Urine / Q000737:chemistry*
chemical_list: D002951:Citrates; D014527:Uric Acid; D008274:Magnesium