title: Conservation of small-airway function by tacrolimus/cyclosporine conversion in the management of bronchiolitis obliterans following lung transplantation.
abstract: We studied serial lung function in 11 patients with bronchiolitis obliterans syndrome who were treated with tacrolimus conversion following lung or heart-lung transplantation. Our results show that tacrolimus conversion slows the decline of lung function in bronchiolitis obliterans syndrome. The attenuation continues for at least 1 year following conversion.
authors: Department of Cardiothoracic Transplantation, Queen Elizabeth Hospital, Birmingham, United Kingdom.
authors: M P
authors: MP
authors: Revell
authors: M E
authors: ME
authors: Lewis
authors: C G
authors: CG
authors: Llewellyn-Jones
authors: I C
authors: IC
authors: Wilson
authors: R S
authors: RS
authors: Bonser
mesh_terms: D001706:Biopsy; D001980:Bronchi / Q000503:physiopathology*; D001989:Bronchiolitis Obliterans / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use*; D018450:Disease Progression; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000187:drug effects; D016041:Heart-Lung Transplantation / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016040:Lung Transplantation / Q000502:physiology; D008450:Maximal Midexpiratory Flow Rate / Q000187:drug effects; D012189:Retrospective Studies; D013147:Spirometry; D018709:Statistics, Nonparametric; D013577:Syndrome; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus