2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2.
Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 (22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.
Zhang
C
C
Ontogen Corporation, Carlsbad, CA 92009, USA.
Sarshar
S
S
Moran
E J
EJ
Krane
S
S
Rodarte
J C
JC
Benbatoul
K D
KD
Dixon
R
R
Mjalli
A M
AM
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000187:drug effects*; D020650:Combinatorial Chemistry Techniques; D018432:Drug Resistance, Multiple; D006207:Half-Life; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D012016:Reference Values
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007093:Imidazoles