What initiates actin polymerization?
For those working on the actin cytoskeleton, a major theme of the 39th annual meeting of the American Society for Cell Biology [http://www.faseb.org/ascb/meetings/am99/+ ++main99mtg.htm] (Washington DC, December 11-15, 1999) was the elucidation of how actin polymerization is initiated. The emphasis was on the regulation and localization of the Arp2/3 complex, which over the last two years has been shown to stimulate actin nucleation, and on the identification of additional proteins that interact with actin and Arp2/3 in a variety of organisms.
Ridley
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Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London W1P 8BT, UK.
D000199:Actins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D011108:Polymers / Q000378:metabolism*
D000199:Actins; D011108:Polymers