title: Aminoanthraquinones as novel ligands at the polyamine binding site on the N-methyl-D-aspartate receptor complex.
abstract: As part of a drug discovery program using high-throughput radioligand-binding assays, aminoanthraquinones were identified as potential modulators of N-methyl-D-aspartate (NMDA) receptor function. Aminoanthraquinones may represent a novel class of polyamine binding site ligands with a unique pharmacophore and may facilitate the rational design of novel NMDA-receptor modulators.
authors: Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536, USA.
authors: A K
authors: AK
authors: Bence
authors: D T
authors: DT
authors: Rogers
authors: D R
authors: DR
authors: Worthen
authors: M
authors: M
authors: Fu
authors: J M
authors: JM
authors: Littleton
authors: P A
authors: PA
authors: Crooks
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D015317:Biogenic Polyamines; D016291:Dizocilpine Maleate / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000378:metabolism; D008024:Ligands; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*
chemical_list: D000880:Anthraquinones; D015317:Biogenic Polyamines; D018691:Excitatory Amino Acid Antagonists; D008024:Ligands; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate