Characteristics of HIV-1-infected patients with CD4:CD8 lymphocyte ratio normalization on antiretroviral therapy.
Antiretroviral therapy for human immunodeficiency virus (HIV)-infection results in normalization of CD4:CD8 T-lymphocyte ratio in about 6% of cases. The T-cell ratio normalization on therapy was associated with a baseline CD4 of over 350 cells per microliter and a T-cell ratio of over 0.5 (for each, p < 0.01), but not with the current level of viral load suppression or compliance with clinic appointments (for each, p > 0.05). The patients with T-cell ratio normalization had a baseline median CD4 count of 428 cells per microliter (range, 353-883 cells per microliter) and a median T-cell ratio of 0.75 (range, 0.54-0.87). We could not address the effect of baseline viral load on T-cell ratio normalization, but there was no association with age, gender, race, HIV risk factor, or the length of antiretroviral therapy.
Zaman
M M
MM
Division of Infectious Diseases, Department of Medicine, Coney Island Hospital and State University of New York Health Science Center at Brooklyn, Brooklyn, New York, USA.
Recco
R A
RA
Raguthu
L
L
Likki
S
S
Reddy
S
S
D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016516:CD4-CD8 Ratio; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1; D006801:Humans; D015994:Incidence; D008297:Male; D011237:Predictive Value of Tests; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D019562:Viral Load
D019380:Anti-HIV Agents