title: Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings.
abstract: BACKGROUND
  Third rather than lateral ventriculomegaly may be a more specific finding in psychosis. The relevance of ventricular abnormality remains unclear.
  
  
  OBJECTIVE
  To investigate the developmental correlates of ventricular enlargement.
  
  
  METHODS
  Information on childhood development and magnetic resonance images in 1.5-mm contiguous sections were collected on 21 patients experiencing a first episode of psychosis.
  
  
  RESULTS
  Patients (n = 21) had significantly less whole brain volume and enlarged third and lateral ventricles compared to controls (n = 25). Third ventricle (r = 0.48, P < 0.03) and lateral ventricle (r = 0.65, P < 0.01) volumes correlated with developmental score. Patients with developmental delay had significantly larger third and lateral ventricles than those without.
  
  
  CONCLUSIONS
  Enlargement of both third and lateral ventricles is found in first-episode psychosis and is related to developmental delay in childhood. Insult to periventricular areas is relevant to the neurobiology of the disease. These findings support the view that schizophrenia involves disturbance of neurodevelopmental processes in some patients.
authors: Section of Cognitive Psychopharmacology, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK. d.fannon@iop.kcl.ac.uk
authors: D
authors: D
authors: Fannon
authors: L
authors: L
authors: Tennakoon
authors: A
authors: A
authors: Sumich
authors: S
authors: S
authors: O'Ceallaigh
authors: V
authors: V
authors: Doku
authors: X
authors: X
authors: Chitnis
authors: J
authors: J
authors: Lowe
authors: W
authors: W
authors: Soni
authors: T
authors: T
authors: Sharma
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002658:Developmental Disabilities / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D004522:Educational Status; D005260:Female; D007839:Functional Laterality; D006801:Humans; D020547:Lateral Ventricles / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011618:Psychotic Disorders / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D012737:Sex Factors; D012959:Socioeconomic Factors; D020542:Third Ventricle / Q000473:pathology*