title: Zuclopenthixol acetate in psychiatric emergencies: looking for evidence from clinical trials.
abstract: BACKGROUND
  Case series and reviews have suggested the effectiveness of zuclopenthixol acetate in the acute management of disturbed behaviour caused by serious mental illnesses. This review investigates the trial-based evidence for these suggestions.
  
  
  METHODS
  All randomized clinical trials comparing zuclopenthixol acetate to other 'standard' treatments for the acute management of those with serious mental illnesses were identified and, if possible, their results summated.
  
  
  RESULTS
  Six trials were identified. All had methodological problems and one did not meet the minimal methodological inclusion criteria. The summary data do not demonstrate that zuclopenthixol acetate is better than 'standard care' for altering behaviour, decreasing the need for supplementary medication, avoiding side-effects, or postponing early discharge against medical advice. One trial, however, presented data that suggested an earlier, more intense level of sedation.
  
  
  CONCLUSIONS
  Recommendations of reviews and open studies for the use of zuclopenthixol acetate in preference to 'standard' treatments in the psychiatric emergency are not supported by evidence from randomized controlled trials.
authors: FIOCRUZ/UERJ, Rio de Janeiro, Brazil.
authors: E
authors: E
authors: Coutinho
authors: M
authors: M
authors: Fenton
authors: C
authors: C
authors: Adams
authors: C
authors: C
authors: Campbell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003006:Clopenthixol / Q000009:adverse effects / Q000627:therapeutic use*; D004637:Emergency Services, Psychiatric; D006801:Humans; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012559:Schizophrenia / Q000188:drug therapy* / Q000534:rehabilitation*
chemical_list: D014150:Antipsychotic Agents; D003006:Clopenthixol