Catalytic antibodies (abzymes) induced by stable transition-state analogs.
This review deals with recent advances in the generation of catalytic antibodies by the immunization of animals with stable transition-state analogs. Characteristic features in the functioning of such abzymes are considered in comparison with traditional enzymes.
Nevinsky
G A
GA
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, 630090, Russia. Nevinsky@niboch.nsc.ru
Semenov
D V
DV
Buneva
V N
VN
D000818:Animals; D017151:Antibodies, Catalytic / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D000911:Antibodies, Monoclonal / Q000096:biosynthesis* / Q000737:chemistry / Q000378:metabolism
D017151:Antibodies, Catalytic; D000911:Antibodies, Monoclonal