Severity of group B streptococcal arthritis in selected strains of laboratory mice.
The susceptibilities of C3H/HeN, BALB/c, and C57BL/6N mouse strains to group B streptococci (GBS) infection were evaluated. C3H/HeN mice developed severe polyarthitis; mild lesions and no lesions were observed in BALB/c and C57BL/6N mice, respectively. A correlation between the severity of arthritis, the number of GBS in the joints, and local interleukin-6 and interleukin-1beta production was evident.
Puliti
M
M
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy.
Bistoni
F
F
von Hunolstein
C
C
Orefici
G
G
Tissi
L
L
D000818:Animals; D001170:Arthritis, Infectious / Q000276:immunology*; D004198:Disease Susceptibility; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013290:Streptococcal Infections / Q000276:immunology*; D013292:Streptococcus agalactiae
D007375:Interleukin-1; D015850:Interleukin-6