[Effects of pikamilon on the brain water-electrolyte balance and in models of responses to the noise and vibration exposure, and their combination with motion sickness].
Electric impedance measurements on awake rabbits with electrodes implanted into cortex, thalamus, and hypothalamus showed that modeling of the noise and general (wide-band) vibration, as well as their combination with sea-sickness action, leads to disturbances in the aqueous-electrolyte balance in brain. This is manifested by extracellular and (less pronounced) intracellular edema development. Picamilon administration (10 mg/kg, i.v.) completely prevented development of the vibration-induced intracellular edema and markedly reduced the development of damage in all other cases studied.
Sapegin
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ID
Pharmacology Department, Simferopol State Medical University, Crimea, Ukraine.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001929:Brain Edema / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D009041:Motion Sickness / Q000188:drug therapy*; D009622:Noise / Q000009:adverse effects*; D011817:Rabbits; D014732:Vibration / Q000009:adverse effects*; D014882:Water-Electrolyte Balance / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*
C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid