[The use of delta-receptor antagonist DuP 734 for correction of the contractile diastolic cardiac dysfunction in reperfusion injury and oxidative stress].
Intraperitoneal administration of the sigma-receptor antagonist DuP 734 (1 mg/kg) 15 min before heart excision produces a decrease in the reperfusion heart contractility and prevented from the reperfusion induced cardiac cell lesion upon global ischemia of the isolated perfused rat heart. At the same time, a preliminary treatment with DuP 734 potentiated the reperfusion induced suppression of the cardiac pump function, while affecting neither the cardiac contractility dysfunction nor the cardiac cell injury during the oxidative stress. It is concluded that DuP 734 is not effective in preventing the myocardial stunning. The cardio-protector effect of DuP 734 during reperfusion is not related to inhibition of the free radical cell damage.
Maslov
L N
LN
Laboratory of Experimental Cardiology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, Russia.
Lishmanov
Iu B
IuB
Rebrova
T Iu
TIu
Gilligan
P
P
Tam
S W
SW
D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D003402:Creatine Kinase / Q000378:metabolism; D003971:Diastole; D005609:Free Radicals / Q000378:metabolism; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D018384:Oxidative Stress; D010880:Piperidines / Q000494:pharmacology*; D017465:Receptors, Opioid, delta / Q000037:antagonists & inhibitors*; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology; D017725:Ventricular Pressure / Q000187:drug effects
D000889:Anti-Arrhythmia Agents; D005609:Free Radicals; D010880:Piperidines; D017465:Receptors, Opioid, delta; C078773:DuP 734; D003402:Creatine Kinase