title: Galanin-like peptide (GALP) is expressed in rat hypothalamus and pituitary, but not in DRG.
abstract: Galanin-like peptide (GALP) was recently purified on the basis of its preferential activation of galanin receptor subtype 2 (GALR2) compared with galanin receptor subtype 1 (GALR1). Using in situ hybridization of adult rat brain, pituitary and dorsal root ganglia (DRG) we demonstrate that GALP mRNA expression is restricted to the arcuate nucleus and median eminence of the hypothalamus, and to the posterior lobe of the pituitary. No expression was detected elsewhere in brain, or in the DRG. In adult mouse, no expression was detected in brain or in DRG either before or after axotomy, suggesting that GALP has no apparent role in the axotomy response of DRG.
authors: University Research Centre for Neuroendocrinology, Bristol University, UK.
authors: N C
authors: NC
authors: Kerr
authors: F E
authors: FE
authors: Holmes
authors: D
authors: D
authors: Wynick
mesh_terms: D000818:Animals; D019771:Axotomy; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D044089:Galanin-Like Peptide; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D016376:Oligonucleotides, Antisense; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D044089:Galanin-Like Peptide; D009419:Nerve Tissue Proteins; D016376:Oligonucleotides, Antisense; D004247:DNA