Hematological characteristics of rats spontaneously developing eosinophilia.
Hematological and genetic characteristics of newly found eosinophilic rats were studied. Hematologically, high blood eosinophil counts started at 6 weeks of age. Almost all 10-week-old rats had eosinophilia with individual counts above 500/microliter and 5 to 100 times the normal level. Proliferating eosinophils had normal morphology. An increase in lymphocyte counts was observed at 5 weeks of age, one week earlier than the onset of eosinophilosis. In bone marrow, proliferation of eosinophils was also observed at 8 weeks of age and thereafter progressed, suggesting a role in the pathogenesis of eosinophilia in this rat. The results of genetic cross experiments revealed the disease to be hereditary. The spontaneously eosinophilic rat therefore warrants attention as a model for studying the underlying mechanisms of human and animal eosinophilia.
Matsumoto
K
K
Institute of Experimental Animals, Shinshu University School of Medicine, Nagano, Japan.
Matsushita
N
N
Tomozawa
H
H
Tagawa
Y
Y
D000375:Aging / Q000502:physiology; D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D002455:Cell Division; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D004802:Eosinophilia / Q000097:blood / Q000235:genetics*; D005260:Female; D007958:Leukocyte Count; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D013047:Specific Pathogen-Free Organisms