Cognitive consequences and central nervous system injury following treatment for childhood leukemia.
OBJECTIVE
To determine the relationship between membrane damage and intellectual and academic abilities in children with acute lymphoblastic leukemia (ALL) and pilot test a math intervention for children with ALL who were affected.


METHODS
Research studies and review articles.


CONCLUSIONS
Despite the prophylactic central nervous system (CNS) treatment for long-term disease-free survival, many children with ALL subsequently experience declines in intellectual and academic skills.


CONCLUSIONS
Improving academic abilities in children who have received CNS treatment is of high priority and may have longlasting implications on quality of life.
Moore
I M
IM
Division of Nursing Practice, College of Nursing, University of Arizona, Tucson 85721-0203, USA.
Espy
K A
KA
Kaufmann
P
P
Kramer
J
J
Kaemingk
K
K
Miketova
P
P
Mollova
N
N
Kaspar
M
M
Pasvogel
A
A
Schram
K
K
Wara
W
W
Hutter
J
J
Matthay
K
K
D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000528:radiation effects; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002648:Child; D003072:Cognition Disorders / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D010743:Phospholipids / Q000134:cerebrospinal fluid*; D010865:Pilot Projects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000532:radiotherapy
D000970:Antineoplastic Agents; D010743:Phospholipids