title: Serial fetal lung volume measurement using three-dimensional ultrasound.
abstract: OBJECTIVE
  To establish reference intervals for fetal lung growth.
  
  
  METHODS
  Longitudinal observational study.
  
  
  METHODS
  Fifty-eight women with initially uncomplicated singleton pregnancies were recruited from the antenatal population of a teaching hospital. Four women were excluded from the final analysis because of complications arising in their pregnancy.
  
  
  METHODS
  Each subject was serially scanned at monthly intervals. At each visit lung volume was measured using an ultrasound-based computerized three-dimensional imaging system. Multilevel models were used to determine conditional and unconditional reference intervals.
  
  
  RESULTS
  Reference intervals for fetal lung growth were derived. Fetal lung volume increases in a non-linear way with gestation.
  
  
  CONCLUSIONS
  Our computerized system has the capacity to be used in conjunction with any standard two-dimensional ultrasound scanner in order to measure volume. Lung volume measurement may be useful in predicting pulmonary hypoplasia.
authors: Department of Obstetrics, Guy's Hospital, London, UK.
authors: A
authors: A
authors: Bahmaie
authors: S W
authors: SW
authors: Hughes
authors: T
authors: T
authors: Clark
authors: A
authors: A
authors: Milner
authors: J
authors: J
authors: Saunders
authors: K
authors: K
authors: Tilling
authors: D J
authors: DJ
authors: Maxwell
mesh_terms: D000328:Adult; D005314:Embryonic and Fetal Development; D005260:Female; D005865:Gestational Age; D006801:Humans; D008137:Longitudinal Studies; D008168:Lung / Q000000981:diagnostic imaging* / Q000196:embryology*; D008403:Mass Screening / Q000379:methods; D011247:Pregnancy; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000379:methods; D016216:Ultrasonography, Prenatal / Q000379:methods*