The interrelationship between production of reactive oxygen intermediates and inflammatory cytokines by peripheral blood leukocytes in vitro from children with food allergy.
In this study, the activity of neutrophils measured using the chemiluminescence test was estimated in 49 children with food allergy. It was shown that average chemiluminescence values without, as well as after, stimulation by formyl-methionyl-leucine phenylalanine and phorbol myristate acetate were considerably higher in children with allergy in comparison to those in the control group. The correlation between the production of reactive oxygen intermediates and interleukin (IL)-4, IL-5 and IL-10 concentration suggests that an autocrine regulatory mechanism may play a role in allergy in children.
Kamer
B
B
Second Division of the Pediatric Clinic, Institute of Polish Mothers Memorial Hospital, Lodz.
Kamer-Bartosinska
A
A
Tchórzewski
H
H
Zeman
K
K
Lukamowicz
J
J
D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005512:Food Hypersensitivity / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D016328:NF-kappa B / Q000502:physiology; D009504:Neutrophils / Q000378:metabolism*; D017382:Reactive Oxygen Species
D016207:Cytokines; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D007073:Immunoglobulin E; D009240:N-Formylmethionine Leucyl-Phenylalanine