title: High-dose methotrexate is lethal to rats. Why give it to children?
authors: P D
authors: PD
authors: Cole
authors: B A
authors: BA
authors: Kamen
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity*; D002648:Child; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity*; D009369:Neoplasms / Q000188:drug therapy*; D012516:Osteosarcoma / Q000188:drug therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D051381:Rats
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate