Dual electroencephalogram markers of human sleep homeostasis: correlation between theta activity in waking and slow-wave activity in sleep.
To investigate the relationship between markers of sleep homeostasis during waking and sleep, the electroencephalogram of eight young males was recorded intermittently during a 40-h waking episode, as well as during baseline and recovery sleep. In the course of extended waking, spectral power of the electroencephalogram in the 5-8Hz band (theta activity) increased. In non-rapid eye movement sleep, power in the 0.75-4.5Hz band (slow-wave activity) was enhanced in the recovery night relative to baseline. Comparison of individual records revealed a positive correlation between the rise rate of theta activity during waking and the increase in slow-wave activity in the first non-rapid eye movement sleep episode. A topographic analysis based on 27 derivations showed that both effects were largest in frontal areas. From these results, we suggest that theta activity in waking and slow-wave activity in sleep are markers of a common homeostatic sleep process.
Finelli
L A
LA
Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland.
Baumann
H
H
Borbély
A A
AA
Achermann
P
P
D000328:Adult; D015415:Biomarkers; D002540:Cerebral Cortex / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D008297:Male; D012890:Sleep / Q000502:physiology*; D013826:Theta Rhythm; D014851:Wakefulness / Q000502:physiology*
D015415:Biomarkers