Efficient epoxidation of alkenes with aqueous hydrogen peroxide catalyzed by methyltrioxorhenium and 3-cyanopyridine.
The epoxidation of alkenes with 30% aqueous hydrogen peroxide is catalyzed efficiently by methyltrioxorhenium (MTO) in the presence of pyridine additives. The addition of 1-10 mol % of 3-cyanopyridine increases the system's efficiency for terminal and trans-disubstituted alkenes resulting in high isolated yields of the corresponding epoxides. The system allows for epoxidation of alkenes with various functional groups. Alkenes leading to acid-sensitive products are efficiently epoxidized using a mixture of pyridine and 3-cyanopyridine as additives. This method is operationally very simple and uses an environmentally benign oxidant. The effects of different pyridine additives on the alkene conversion and the catalyst lifetime are discussed.
Adolfsson
H
H
Department of Chemistry and the Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 90237, USA. hansa@organ.su.se
Copéret
C
C
Chiang
J P
JP
Yudin
A K
AK
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
D000475:Alkenes; D004852:Epoxy Compounds; D009942:Organometallic Compounds; D011725:Pyridines; C411866:methyltrioxorhenium VII; D006861:Hydrogen Peroxide; C020729:3-cyanopyridine