[Molecular basis and mechanisms of Influenza viruses adaptation to reproduction in murine lung].
Analyzes modern data on the role of individual segments of genome in acquisition of virulence during influenza virus adaptation to reproduction in the lungs of mice. Discusses the significance of molecular mechanisms (loss of potential glycosylation site(s), optimum pH of HA-mediated fusion, beta-inhibitor sensitivity, pH-dependent association/dissociation of M1 protein with viral RNP, and host factors) involved in adaptation of influenza virus to a new host.
Govorkova
E A
EA
Smirnov
Iu A
IuA
D000220:Adaptation, Biological; D000818:Animals; D008168:Lung / Q000821:virology*; D051379:Mice; D009975:Orthomyxoviridae / Q000502:physiology*; D014779:Virus Replication