title: Organic osmolyte channels: a comparative view.
abstract: Cells respond to osmotic swelling by releasing inorganic ions and small organic molecules (organic osmolytes). In many cell-types, osmotic swelling results in the activation of an outwardly-rectifying anion-selective current. The channel underlying this current has a significant permeability to a number of organic osmolytes and may play a role in the hypoosmotically-activated efflux of these compounds. However, there is also evidence that the volume-regulatory efflux of organic osmolytes involves other pathways which may be selective for neutral osmolytes over anions.
authors: Division of Biochemistry and Molecular Biology, Faculty of Science, The Australian National University, Canberra, Australia.
authors: P R
authors: PR
authors: Junankar
authors: K
authors: K
authors: Kirk
mesh_terms: D000818:Animals; D009930:Organic Chemicals / Q000378:metabolism*; D009997:Osmotic Pressure
chemical_list: D009930:Organic Chemicals