title: Tolerance to the foeto-placental 'graft': ten ways to support a child for nine months.
abstract: Tolerance to the foetal 'allograft' has been extensively studied in the past few years, providing interesting new insights. In addition to a potential role for HLA-G, which has been widely discussed, there are hypotheses suggesting roles for several other molecules or cells: leukemia inhibitory factor and its receptor; indoleamine 2. 3-dioxygenase; the Th1/Th2 balance; suppressor macrophages; hormones such as progesterone or the placental growth hormone; CD95 and its ligand; and, as recently proposed, annexin II. Tolerance of the foetal allograft is probably the consequence of a wide panel of mechanisms that may or may not be pregnancy-specific, that are of major or secondary importance and that may be interconnected.
authors: Institute of Human Histology, University of Liege, 20 Rue de Pitteurs, B-4020 Liege, Belgium.
authors: O
authors: O
authors: Thellin
authors: B
authors: B
authors: Coumans
authors: W
authors: W
authors: Zorzi
authors: A
authors: A
authors: Igout
authors: E
authors: E
authors: Heinen
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D010920:Placenta / Q000276:immunology; D011247:Pregnancy / Q000276:immunology*