title: Open pergolide treatment of tricyclic and heterocyclic antidepressant-resistant depression.
abstract: BACKGROUND
  Recently, a dopamine hypothesis of depression was put forward, and several studies have demonstrated that direct and indirect dopamine agonists have antidepressant effects.
  
  
  METHODS
  Using Clinical Global Impressions, we evaluated the efficacy of 4-week treatment of pergolide as an antidepressant adjuvant involving 20 unipolar depressed patients who were refractory to standard treatment with antidepressants.
  
  
  RESULTS
  One patients (5%) were very much improved, seven (35%) much improved, four (20%) minimally improved, six (30%) no change or worse, and two (10%) not assessed. There was no significant difference in any clinical factors between the pergolide responder and non-responder group.
  
  
  CONCLUSIONS
  This study was a non-blind open trial, and pergolide was added to tricyclic and heterocyclic antidepressants.
  
  
  CONCLUSIONS
  Pergolide may be useful as an antidepressant adjuvant, suggesting a potential role for dopamine-2 stimulation in the antidepressant response.
authors: Department of Psychiatry, Hokkaido University School of Medicine, North 15, West 7, Kita-ku, 060-8638, Sapporo, Japan. tizumi@med.hokudai.ac.jp
authors: T
authors: T
authors: Izumi
authors: T
authors: T
authors: Inoue
authors: N
authors: N
authors: Kitagawa
authors: N
authors: N
authors: Nishi
authors: S
authors: S
authors: Shimanaka
authors: Y
authors: Y
authors: Takahashi
authors: I
authors: I
authors: Kusumi
authors: Y
authors: Y
authors: Odagaki
authors: K
authors: K
authors: Denda
authors: T
authors: T
authors: Ohmori
authors: T
authors: T
authors: Koyama
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010479:Pergolide / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D000928:Antidepressive Agents; D018491:Dopamine Agonists; D010479:Pergolide