title: Novel type of BCR-ABL transcript in a chronic myelogenous leukaemia patient relapsed after bone marrow transplantation.
abstract: We identified a novel BCR-ABL transcript in a chronic myelogenous leukaemia (CML) patient who relapsed after bone marrow transplantation (BMT), containing a fusion between part of BCR exon 3, 44 nucleotides derived from ABL intron 1b and ABL exon 2. The breakpoints were located within BCR exon 3 on chromosome 22 and within the ABL intron 1b on chromosome 9, and the transcript derives from a splicing of ABL exon 2 to a putative splicing acceptor site 44 nucleotides downstream to the breakpoint on chromosome 9. The patient's clinical course strengthens the idea that short forms of BCR-ABL transcripts are associated with a more aggressive disease.
authors: Haematology Department of Reina Sofía Hospital, Córdoba, Spain.
authors: J
authors: J
authors: Roman
authors: A
authors: A
authors: Parziale
authors: E
authors: E
authors: Gottardi
authors: D
authors: D
authors: De Micheli
authors: D
authors: D
authors: Cilloni
authors: M
authors: M
authors: Tiribelli
authors: M G
authors: MG
authors: Gonzalez
authors: M
authors: M
authors: del Carmen Rodriguez
authors: A
authors: A
authors: Torres
authors: G
authors: G
authors: Saglio
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D020869:Gene Expression Profiling; D015321:Gene Rearrangement; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000601:surgery; D008297:Male; D012008:Recurrence; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D016044:Fusion Proteins, bcr-abl