title: Use of pelvic flexure biopsies to predict survival after large colon torsion in horses.
abstract: OBJECTIVE
  To determine if morphologic evaluation of intraoperative biopsies of the large colon could be used to accurately predict outcome in horses with large colon torsion.
  
  
  METHODS
  Clinical study.
  
  
  METHODS
  Fifty-four horses with large colon torsion.
  
  
  METHODS
  A full-thickness biopsy was collected from the pelvic flexure of the ascending colon after correction of naturally occurring colonic torsion. Morphologic changes were evaluated and graded for interstitial tissue to crypt ratio (I:C ratio), percentage loss of superficial and glandular epithelium, and the degree of hemorrhage and edema. These variables were then used to predict survival.
  
  
  RESULTS
  Morphologic variables could be used to correctly predict survival or death in 51 horses (P < .0001). This corresponded to a sensitivity of 95.1% (82.2%-99.2%; 95% CI) and a specificity of 92.3% (62.0%-99.6%; 95% CI). Of 6 horses that had colonic resection, 5 survived; an accurate prediction of outcome based on morphologic criteria was made for each horse.
  
  
  CONCLUSIONS
  Interpretation of changes in colonic morphology can be used to accurately predict postoperative survival in horses with large colon torsion.
  
  
  CONCLUSIONS
  Use of frozen colonic tissue sections is a rapid, reliable, and relatively inexpensive method for assessing morphologic damage associated with large colon torsion during surgery. Intraoperative evaluation of pelvic flexure biopsies can aid in the prediction of survival and guide surgical judgment as to the need for colonic resection.
authors: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
authors: L
authors: L
authors: Van Hoogmoed
authors: J R
authors: JR
authors: Snyder
authors: J R
authors: JR
authors: Pascoe
authors: H
authors: H
authors: Olander
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D003106:Colon / Q000098:blood supply / Q000473:pathology*; D003112:Colonic Pseudo-Obstruction / Q000401:mortality / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D006734:Horse Diseases / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D006736:Horses; D007432:Intraoperative Period; D011379:Prognosis; D011996:Records / Q000662:veterinary; D012039:Regional Blood Flow; D016019:Survival Analysis; D014102:Torsion Abnormality / Q000662:veterinary; D016896:Treatment Outcome