[Effect of oral antidiabetic agents on fructose biosynthesis].
The oral antidiabetic drugs (glyformin, glyclaside, glycvidon, glybenclamide) at a concentration of 10-196 mM affect the synthesis of fructosamine in an incubation medium containing 40 mM of glucose and 5% of human serum albumin. All these drugs decrease the fructosamine yield measured in the medium on the 4th day of incubation at 37-198 degrees C, while the effect of glycvidon is pronounced even on the 7th day. The introduction of glyformin, glycvidon, and glybenclamide at an amount close to the maximum daily dose over a period of one month reduces the level of fructosamine in the blood of rats with experimental diabetes mellitus, while not affecting the level of glucose in the blood of test animals. Thus, the oral antidiabetic drugs reduce the level of fructosamine--an agent known to modify the protein structure, thus favoring the development of complications in the course of diabetes under permanent hyperglycemia conditions.
Kulagin
O L
OL
Pharmacology Department, Samara State Medical University, Russia.
D000284:Administration, Oral; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D019270:Fructosamine / Q000096:biosynthesis* / Q000138:chemical synthesis*; D005907:Gliclazide / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D005905:Glyburide / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D006031:Glycosylation; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D012709:Serum Albumin / Q000737:chemistry; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology
D007004:Hypoglycemic Agents; D012709:Serum Albumin; D013453:Sulfonylurea Compounds; D019270:Fructosamine; C010969:gliquidone; D005907:Gliclazide; D005905:Glyburide