Postprandial triglyceride response in patients with polycystic ovary syndrome: relationship with waist-to-hip ratio and insulin.
OBJECTIVE
To examine the postprandial triglyceride response to a high-fat meal in women with polycystic ovary syndrome (PCOS) compared with a matched control group.


METHODS
Controlled clinical study.


METHODS
Department of Endocrinology and Pathophysiology, School of Medicine, Universidad de Los Andes.


METHODS
18 Hispanic women with PCOS (nine overweight and nine nonobese) and 9 healthy control women.


METHODS
Biometric measures and blood sample collection.


METHODS
Insulin and glucose levels during a standard oral glucose tolerance test. Plasma triglyceride, cholesterol, and high-density lipoprotein cholesterol levels were measured at baseline and at 4, 5, and 6 h after a high-fat meal.


RESULTS
Both obese and nonobese PCOS women had higher waist-to-hip ratios than controls. PCOS women had higher levels of fasting and postglucose insulin and fasting triglyceride and postprandial triglyceride response and had lower levels of postprandial high-density lipoprotein cholesterol response, but no significant differences within PCOS groups were observed.


CONCLUSIONS
An expanded postprandial hypertriglyceridemia in PCOS women is related to a higher waist-to-hip ratio and insulin resistance, regardless of obesity, and contributes to increase the risk for coronary artery disease.
Velázquez M
E
E
Unidad de Endocrinología, Hospital Universitario de Los Andes, Mérida, Venezuela. elsyvm@yahoo.com
Bellabarba
G A
GA
Mendoza
S
S
Sánchez
L
L
D000328:Adult; D001824:Body Constitution; D008076:Cholesterol, HDL / Q000097:blood; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000209:etiology; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D019518:Postprandial Period / Q000502:physiology*; D012016:Reference Values; D014280:Triglycerides / Q000097:blood*
D008076:Cholesterol, HDL; D007328:Insulin; D014280:Triglycerides