title: Differential inhibitory effects of sophoricoside analogs on bioactivity of several cytokines.
abstract: Effects of sophoricoside and its analogs on proinflammatory cytokines have been investigated. Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactivities. None of the sophoricoside analogs showed inhibitory effects on both IL-1beta and TNF-alpha bioactivities. Among the compounds, sophoricoside exhibited the highest inhibitory effects on IL-5, IL-3 and IL-6 bioactivities with IC50 values of 1.9 microM, 6.9 microM and 6.0 microM, respectively and orobol did show on GM-CSF bioactivity with an IC50 value of 18.0 microM. The result would provide an additional mechanism by which the compounds exert immunosuppressive and anti-inflammatory effects.
authors: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
authors: J
authors: J
authors: Yun
authors: C K
authors: CK
authors: Lee
authors: I M
authors: IM
authors: Chang
authors: K
authors: K
authors: Takatsu
authors: T
authors: T
authors: Hirano
authors: K R
authors: KR
authors: Min
authors: M K
authors: MK
authors: Lee
authors: Y
authors: Y
authors: Kim
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects; D001578:Benzopyrans / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D019833:Genistein / Q000494:pharmacology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D007377:Interleukin-3 / Q000494:pharmacology; D015848:Interleukin-5 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D007529:Isoflavones / Q000494:pharmacology*; D004915:Leukemia, Erythroblastic, Acute; D008545:Melanoma; D051379:Mice; D011994:Recombinant Proteins / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D001578:Benzopyrans; D016207:Cytokines; D005419:Flavonoids; D007375:Interleukin-1; D007377:Interleukin-3; D015848:Interleukin-5; D015850:Interleukin-6; D007529:Isoflavones; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; C120642:sophoricoside; C040641:genistin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D019833:Genistein; C059811:orobol