title: Structural basis of cell-cell interactions in the immune system.
abstract: During the past year, advances in our understanding of receptor-ligand interactions between opposing cell surfaces have occurred at a structural level. These include adhesion involving CD2-CD58, antigen-specific T-cell receptor interactions with peptides bound to major histocompatibility complex molecules (both pMHCI and pMHCII), the CD8alphaalpha co-receptor-pMHCI interaction and the binding of two distinct classes of natural killer receptors to self-MHC ligands.
authors: Dana-Farber Cancer Institute and Department of Pediatrics and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. jwang@red.dfci.harvard.edu
authors: J
authors: J
authors: Wang
authors: E L
authors: EL
authors: Reinherz
mesh_terms: D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism; D002448:Cell Adhesion; D007107:Immune System / Q000166:cytology*; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D011948:Receptors, Antigen, T-Cell