title: Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication.
abstract: A non-nucleoside class of compounds that inhibits the replication of hepatitis B virus (HBV) in cell culture has been discovered. A series of substituted analogues of phenylpropenamide 6 has been prepared and evaluated in the HepAD38 cellular assay. Structure-activity relationships of this series are discussed.
authors: Avid Therapeutics, Inc., Philadelphia, PA 19104, USA. robert_perni@vpharm.com
authors: R B
authors: RB
authors: Perni
authors: S C
authors: SC
authors: Conway
authors: S K
authors: SK
authors: Ladner
authors: K
authors: K
authors: Zaifert
authors: M J
authors: MJ
authors: Otto
authors: R W
authors: RW
authors: King
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006515:Hepatitis B virus / Q000187:drug effects* / Q000502:physiology; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D001549:Benzamides; D010880:Piperidines