title: Adenosine triphosphate for cardioversion of supraventricular tachycardia in two hydropic fetuses.
abstract: OBJECTIVE
  We performed a retrospective study to check the effectiveness of adenosine triphosphate (Striadyne) for cardioversion of fetal supraventricular tachycardia (SVT) and to evaluate neonatal outcome after prenatal treatment of severe SVT with fetal hydrops.
  
  
  METHODS
  Two hydropic fetuses with SVT were treated with Striadyne injection into the umbilical vein, as an additional treatment to the digoxin given intravenously to the mother. Both fetuses were in severe condition, with ultrasound, Doppler and laboratory signs of fetal distress and congestive heart failure.
  
  
  RESULTS
  Sinus rhythm was obtained in both cases for different periods of time, without side effects of Striadyne. The children survived. There were severe cardiac and neurologic problems after delivery.
  
  
  CONCLUSIONS
  Striadyne was an effective drug in converting SVT to the sinus rhythm in hydropic fetuses. Digoxin was useless in these fetuses in spite of the therapeutic level which was obtained in both mothers. We suppose that fetal SVT causing fetal hydrops could be the reason of brain damage, and intensive antiarrhythmic treatment seemed to be necessary.
authors: Department of Cardiology, The Children's Memorial Health Institute, Warsaw, Poland. joanna@czd.waw.pl
authors: J H
authors: JH
authors: Dangel
authors: T
authors: T
authors: Roszkowski
authors: K
authors: K
authors: Bieganowska
authors: K
authors: K
authors: Kubicka
authors: J
authors: J
authors: Ganowicz
mesh_terms: D000255:Adenosine Triphosphate / Q000008:administration & dosage*; D000328:Adult; D004452:Echocardiography; D004554:Electric Countershock; D005260:Female; D005315:Fetal Diseases; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D015160:Hydrops Fetalis / Q000188:drug therapy* / Q000209:etiology; D011247:Pregnancy; D013617:Tachycardia, Supraventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016216:Ultrasonography, Prenatal
chemical_list: D000255:Adenosine Triphosphate