Epithelioid trophoblastic tumor metastatic to the vagina: an immunohistochemical and ultrastructural study.
We describe an epithelioid trophoblastic tumor (ETT) metastatic to the vagina in a 30-year-old Japanese woman. A polypoid tumor in the vaginal orifice was composed of nests of intermediate trophoblastic cells that showed a striking epithelioid appearance. In the hysterectomy specimen, a tumor infiltrated through the myometrium and showed histologic findings similar to those of the vaginal tumor. The tumor cells were positive for cytokeratin, inhibin-alpha, and melanoma cell adhesion molecule (Mel-CAM, CD146) but were only focally positive for human placental lactogen. Electron microscopic examination revealed bundles of well-developed, intermediate-type filaments surrounding the nuclei.
Ohira
S
S
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan.
Yamazaki
T
T
Hatano
H
H
Harada
O
O
Toki
T
T
Konishi
I
I
D000328:Adult; D015703:Antigens, CD; D000954:Antigens, Surface / Q000032:analysis; D001706:Biopsy; D051929:CD146 Antigen; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000032:analysis; D007382:Intermediate Filaments / Q000473:pathology; D007633:Keratins / Q000032:analysis; D008562:Membrane Glycoproteins; D008854:Microscopy, Electron; D009215:Myometrium / Q000473:pathology; D019006:Neural Cell Adhesion Molecules; D010928:Placental Lactogen / Q000032:analysis; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000737:chemistry / Q000473:pathology / Q000556:secondary*; D014594:Uterine Neoplasms; D014625:Vaginal Neoplasms / Q000737:chemistry / Q000473:pathology / Q000556:secondary*
D015703:Antigens, CD; D000954:Antigens, Surface; D051929:CD146 Antigen; C497902:MCAM protein, human; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules; C094377:inhibin-alpha subunit; D007265:Inhibins; D007633:Keratins; D010928:Placental Lactogen