title: [Primary lateral sclerosis with breast cancer, a potential paraneoplastic neurological syndrome].
abstract: Few reports indicate that motor neuron diseases may have paraneoplastic origin. A 70 year-old woman suffering from progressive upper motor neuron disease is presented. Laboratory, radiological and neurophysiologic studies were compatible with primary lateral sclerosis. Six years later a routine screening led to the discovery of a breast cancer, suggesting that the upper motor neuron syndrome could be paraneoplastic. So, in female patients with primary lateral sclerosis, a mammography should be recommended to search for breast cancer.
authors: Clinique Neurologique, CHU Bretonneau, Tours. corcia@med.univ-tours.fr
authors: P
authors: P
authors: Corcia
authors: J
authors: J
authors: Honnorat
authors: A M
authors: AM
authors: Guennoc
authors: B
authors: B
authors: de Toffol
authors: A
authors: A
authors: Autret
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D001943:Breast Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D016472:Motor Neuron Disease / Q000175:diagnosis* / Q000209:etiology*; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis* / Q000209:etiology*; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D013629:Tamoxifen