T cell differentiation: a mechanistic view.
It has recently become clear that cytokine expression by T cells involves epigenetic changes in chromatin structure, locus accessibility and DNA methylation that occur during differentiation of naive T cells into mature effector T cells. These changes require the coordinate actions of antigen- and cytokine-induced transcription factors, chromatin remodeling complexes, histone-modifying enzymes and subset-specific transcription factors.
Avni
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Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. avni@cbr.harvard.edu
Rao
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D000818:Animals; D002843:Chromatin; D006801:Humans; D019891:Leukopoiesis; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000276:immunology
D002843:Chromatin; D014157:Transcription Factors