Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root.
Hypoglycemic, diuretic and hypocholesterolemic effects of roots of W. somnifera (ashvagandha) were assessed on human subjects. Six mild NIDDM subjects and six mild hypercholesterolemic subjects were treated with the powder of roots of W. somnifera for 30 days. Suitable parameters were studied in the blood and urine samples of the subjects along with dietary pattern before and at the end of treatment period. Decrease in blood glucose was comparable to that of an oral hypoglycemic drug. Significant increase in urine sodium, urine volume, significant decrease in serum cholesterol, triglycerides, LDL (low density lipoproteins) and VLDL (very low density lipoproteins) cholesterol were observed indicating that root of W. somnifera is a potential source of hypoglycemic, diuretic and hypocholesterolemic agents. Clinical observations revealed no adverse effects.
Andallu
B
B
Department of Home Science, Sri Satya Sai Institute of Higher Learning, Anantapur 515001, India.
Radhika
B
B
D000328:Adult; D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000032:analysis; D002214:Capsules; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D009318:Natriuresis / Q000187:drug effects; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011188:Potassium / Q000032:analysis; D011208:Powders; D012964:Sodium / Q000032:analysis; D019657:Solanaceae / Q000737:chemistry*
D000924:Anticholesteremic Agents; D001786:Blood Glucose; D002214:Capsules; D004232:Diuretics; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D011208:Powders; D012964:Sodium; D011188:Potassium