Mechanisms of transcriptional activation of cAMP-responsive element-binding protein CREB.
The CREB-CREM transcription factors are the main gene regulatory effectors of the cAMP signaling pathway. The investigations of this family of transcription factors had a profound impact on the understanding of signaling-induced gene transcription. Here we discuss some key aspects of the underlying biology, review transcriptional activation by CREB proteins through transcription cofactors and present novel insights into the context- and position-specific function of CREB on complex genes.
Haus-Seuffert
P
P
Institute of Molecular Immunology, Department for Proteinbiochemistry, GSF München, Germany.
Meisterernst
M
M
D051697:Activating Transcription Factor 1; D000595:Amino Acid Sequence; D000818:Animals; D051786:Cyclic AMP Response Element Modulator; D017362:Cyclic AMP Response Element-Binding Protein / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008568:Memory / Q000502:physiology; D008969:Molecular Sequence Data; D012097:Repressor Proteins; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D051697:Activating Transcription Factor 1; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D051786:Cyclic AMP Response Element Modulator