Neurobiology of interleukin-1 receptors: getting the message.
Binding of the pro-inflammatory cytokine interleukin-1 (IL-1) in the brain was first shown a decade ago [1]. Interleukin-1 receptors (IL-1R) in the brain were, at that time, proposed to play a role in mediating symptoms of sickness such as fever, activation of the hypothalamo-pituitary adrenal (HPA)-axis, behavioural depression and increased sleeping. Two years later, IL-1 immunoreactivity was shown in microglia of patients with Alzheimer's disease [2]. Subsequent studies provided evidence for IL-1 expression in most acute and chronic CNS pathologies and gave rise to the concept that glial IL-1 contributes to an inflammatory response in the brain. Recently, new members of the IL-1 receptor family have been discovered and roles for brain IL-1 other than in inflammation are starting to emerge. During a recent meeting* in Biarritz, leading experts in the field reflected on the accomplishments and prospects in this rapidly expanding area of neurobiology.
Konsman
J P
JP
INRA-INSERM U. 394, Institut François Magendie, rue Camille-Saint-Saëns, 33077 Bordeaux Cedex, France. jpkonsman@hotmail.com
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D000210:Acute-Phase Reaction / Q000276:immunology; D000818:Animals; D001921:Brain / Q000276:immunology / Q000502:physiology*; D001927:Brain Diseases / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology / Q000502:physiology*; D051379:Mice; D009410:Nerve Degeneration / Q000276:immunology; D020033:Protein Isoforms / Q000276:immunology; D017472:Receptors, Interleukin-1 / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction
D007375:Interleukin-1; D020033:Protein Isoforms; D017472:Receptors, Interleukin-1