title: Molecular weight dependency on the production of the TNF stimulated by fractions of rye (1-->3),(1-->4)-beta-D-glucan.
abstract: Mixed-linkage (1-->3),(1-->4)-beta-D-glucan with a weight average molecular weight varying between 79,800 and 13,900 was purified from rye. These fractions were used for stimulation of human monocytes to produce tumour necrosis factor (TNF). A mixed-linkage beta-glucan with a weight average molecular weight of 18,900 was found to be the most potent immunostimulator.
authors: Department of Food Science, Swedish University of Agricultural Sciences, PO Box 7051, SE-750 07 Uppsala, Sweden. Hanno.Roubroecks@lmv.slu.se
authors: J P
authors: JP
authors: Roubroeks
authors: G
authors: G
authors: Skjåk-Braek
authors: L
authors: L
authors: Ryan
authors: B E
authors: BE
authors: Christensen
mesh_terms: D005936:Glucans / Q000276:immunology*; D006801:Humans; D008970:Molecular Weight; D009000:Monocytes / Q000276:immunology*; D012434:Secale; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D047071:beta-Glucans
chemical_list: D005936:Glucans; D014409:Tumor Necrosis Factor-alpha; D047071:beta-Glucans; C067858:beta-glucan, (1-3)(1-4)-