High-performance liquid chromatographic assay of trandolapril in capsules.
Rapid, simple and accurate chromatographic (HPLC) method for the determination of trandolapril was elaborated. Samples were chromatographed on a LiChrosorb RP-18 column and the mobile phase was acetonitrile -0.067 M phosphate buffer pH 2.7 (7:3, v/v). The UV detection at 220 nm and benazepril as an internal standard were used. The method was tested for linearity (over the range 4-20 micrograms.ml-1), precision and accuracy and was successfully applied for the quantitative determination of trandolapril in capsules.
Gumieniczek
A
A
Department of Medicinal Chemistry, Medical Academy 6 Chodźki Str., 20-093 Lublin, Poland.
Hopkała
H
H
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D002138:Calibration; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D007211:Indoles / Q000032:analysis*; D011786:Quality Control
D000806:Angiotensin-Converting Enzyme Inhibitors; D002214:Capsules; D007211:Indoles; C052035:trandolapril