Feigrisolides A, B, C and D, new lactones with antibacterial activities from Streptomyces griseus.
Four new lactone compounds, named feigrisolides A to D (1 to 4), have been isolated from Streptomyces griseus. The chemical structures were determined by detail analysis of their spectroscopic data and chemical transformations. Structurally, the feigrisolides A (1) and B (2) are hepta-lactones, feigrisolide C (3) and D (4) are 16-membered macrodiolides. Biological studies showed that feigrisolide B (2) exhibited strong antibacterial, as well as medium cyctotoxic, and antiviral activities. Feigrisolides A (1), C (3) and D (4) are medium inhibitors of 3alpha-hydroxysteroid-dehydrogenase (3alpha-HSD) inhibiting activity.
Tang
Y Q
YQ
Hans-Knöll-Institut für Naturstoff-Forschung e.V., Jena, Germany.
Sattler
I
I
Thiericke
R
R
Grabley
S
S
Feng
X Z
XZ
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000201:enzymology; D004354:Drug Screening Assays, Antitumor; D029822:Enterovirus B, Human / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors; D020014:K562 Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects / Q000201:enzymology; D013305:Streptomyces griseus / Q000737:chemistry* / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D007783:Lactones; C417114:feigrisolide A; C417115:feigrisolide B; C417116:feigrisolide C; C417117:feigrisolide D; D006913:Hydroxysteroid Dehydrogenases; D014969:Xanthine Oxidase