title: [Anuria in HIV+ patients treated with indinavir].
abstract: OBJECTIVE
  Two cases of oliguric acute renal failure in HIV+ patients treated with indinavir are described.
  
  
  METHODS
  Patient evaluation included blood analysis, urinalysis, abdominal x-rays, renal US and IVP.
  
  
  RESULTS
  Both cases resolved with discontinuation of drug therapy, administration of fluids and urine acidification.
  
  
  CONCLUSIONS
  Severe acute renal failure is an uncommon complication in HIV+ patients treated with indinavir. This drug has a great tendency to precipitate in urine. The severity of the crystalluria depends on the drug dose and urinary pH, and can cause tubulointerstitial nephritis and urinary calculi with obstruction of the urinary tract.
authors: Servicio de Urología, Hospital Son Dureta, Palma de Mallorca, España.
authors: M J
authors: MJ
authors: Rebassa Llull
authors: A
authors: A
authors: Conte Visús
authors: F
authors: F
authors: Grases Freixedas
authors: D
authors: D
authors: Muñoz Vélez
authors: A
authors: A
authors: Mus Malleu
authors: I
authors: I
authors: Torrens Darder
authors: C G
authors: CG
authors: Sanz-Gadea
authors: M
authors: M
authors: Ozonas Moragues
mesh_terms: D000328:Adult; D001002:Anuria / Q000139:chemically induced*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir