[Anuria in HIV+ patients treated with indinavir].
OBJECTIVE
Two cases of oliguric acute renal failure in HIV+ patients treated with indinavir are described.


METHODS
Patient evaluation included blood analysis, urinalysis, abdominal x-rays, renal US and IVP.


RESULTS
Both cases resolved with discontinuation of drug therapy, administration of fluids and urine acidification.


CONCLUSIONS
Severe acute renal failure is an uncommon complication in HIV+ patients treated with indinavir. This drug has a great tendency to precipitate in urine. The severity of the crystalluria depends on the drug dose and urinary pH, and can cause tubulointerstitial nephritis and urinary calculi with obstruction of the urinary tract.
Rebassa Llull
M J
MJ
Servicio de Urología, Hospital Son Dureta, Palma de Mallorca, España.
Conte Visús
A
A
Grases Freixedas
F
F
Muñoz Vélez
D
D
Mus Malleu
A
A
Torrens Darder
I
I
Sanz-Gadea
C G
CG
Ozonas Moragues
M
M
D000328:Adult; D001002:Anuria / Q000139:chemically induced*; D017320:HIV Protease Inhibitors / Q000009:adverse effects*; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D017320:HIV Protease Inhibitors; D019469:Indinavir