Review of outcome measurement instruments in Alzheimer's disease drug trials: psychometric properties of behavior and mood scales.
This article reviews the reliability and validity of eight scales for behavior and mood problems that were identified in a comparative analysis of Alzheimer's disease (AD) drug trials. The scales are the Brief Psychiatric Rating Scale, the Alzheimer's Disease Assessment Scale-noncognitive, the Relative's Assessment of Global Symptomatology, the Consortium to Establish a Registry for Alzheimer's Disease-Behavior Rating Scale for Dementia, the Dementia Behavior Disturbance scale, the Neuropsychiatric Inventory, and two scales for depressive symptoms, the Cornell Scale for Depression in Dementia and the Dementia Mood Assessment Scale. This article also examines methodological limitations in the way the published literature has assessed the psychometric properties of these scales. The aim is to help clinicians and potential trial investigators select appropriate measurement instruments with which to assess behavior and mood problems in AD and to assist AD researchers in the evaluation of the psychometric properties of such scales.
Perrault
A
A
Centre for Clinical Epidemiology and Community Studies, Jewish General Hospital, Montreal, Quebec.
Oremus
M
M
Demers
L
L
Vida
S
S
Wolfson
C
C
D000342:Affective Symptoms / Q000188:drug therapy*; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D018697:Nootropic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017063:Outcome Assessment, Health Care; D011594:Psychometrics
D018697:Nootropic Agents