title: Can acute interstitial pneumonia be differentiated from bronchiolitis obliterans organizing pneumonia by high-resolution CT?
abstract: OBJECTIVE
  In the early stages, clinical and chest radiographic findings of acute interstitial pneumonia (AIP) are often similar to those of bronchiolitis obliterans organizing pneumonia (BOOP). However, patients with AIP have a poor prognosis, while those with BOOP can achieve a complete recovery after corticosteroid therapy. The objective of this study was to identify differences in high-resolution CT (HRCT) findings between the two diseases.
  
  
  METHODS
  The study included 27 patients with AIP and 14 with BOOP who were histologically diagnosed [open-lung biopsy (n=7), autopsy (n=17), transbronchial lung biopsy (n=17)]. The frequency and distribution of various HRCT findings for each disease were retrospectively evaluated.
  
  
  RESULTS
  Traction bronchiectasis, interlobular septal thickening, and intralobular reticular opacities were significantly more prevalent in AIP (92.6%, 85.2%, and 59.3%, respectively) than in BOOP (42.9%, 35.7%, and 14.3%, respectively) (p<0.01). Parenchymal nodules and peripheral distribution were more prevalent in BOOP (28.6% and 57.1%, respectively) than in AIP (7.4% and 14.8%, respectively) (p<0.01). Areas with ground-glass attenuation, air-space consolidation, and architectural distortion were common in both AIP and BOOP.
  
  
  CONCLUSIONS
  For a differential diagnosis of AIP and BOOP, special attention should be given to the following HRCT findings: traction bronchiectasis, interlobular septal thickening, intralobular reticular opacities, parenchymal nodules, pleural effusion, and peripheral zone predominance.
authors: Department of Radiology, Osaka University Medical School, Suita, Japan.
authors: N
authors: N
authors: Mihara
authors: T
authors: T
authors: Johkoh
authors: K
authors: K
authors: Ichikado
authors: O
authors: O
authors: Honda
authors: M
authors: M
authors: Higashi
authors: N
authors: N
authors: Tomiyama
authors: M
authors: M
authors: Maeda
authors: S
authors: S
authors: Hamada
authors: H
authors: H
authors: Naito
authors: H
authors: H
authors: Nakamura
authors: S
authors: S
authors: Yoshida
authors: M
authors: M
authors: Akira
authors: S
authors: S
authors: Yamamoto
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001987:Bronchiectasis / Q000000981:diagnostic imaging; D016009:Chi-Square Distribution; D018549:Cryptogenic Organizing Pneumonia / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000000981:diagnostic imaging; D011379:Prognosis; D012189:Retrospective Studies; D015898:Tomography Scanners, X-Ray Computed; D014057:Tomography, X-Ray Computed / Q000379:methods