Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow.
Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.
Mezey
E
E
Basic Neuroscience Program, Laboratory of Developmental Neurogenetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. mezey@codon.nih.gov
Chandross
K J
KJ
Harta
G
G
Maki
R A
RA
McKercher
S R
SR
D000818:Animals; D000941:Antigens / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D001854:Bone Marrow Cells / Q000166:cytology* / Q000502:physiology; D016026:Bone Marrow Transplantation; D001921:Brain / Q000166:cytology*; D002454:Cell Differentiation; D002465:Cell Movement; D005260:Female; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000032:analysis; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018613:Microscopy, Confocal; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000276:immunology; D064231:Nestin; D009474:Neurons / Q000737:chemistry / Q000166:cytology* / Q000276:immunology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000737:chemistry / Q000166:cytology*; D014998:Y Chromosome
D000941:Antigens; D015415:Biomarkers; D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; C577485:Nes protein, mouse; D064231:Nestin; D010751:Phosphopyruvate Hydratase