title: The use of clinical CT for baseline bone density assessment.
abstract: OBJECTIVE
  Many patients having an abnormal initial bone densitometry study have had a previous abdominal/pelvic computed tomography (CT) for other clinical reasons. This study evaluates if a nondedicated quantitative CT (QCT) abdominal/pelvic CT scan could be used as reliable baseline data for subsequent dedicated bone density studies.
  
  
  METHODS
  Twenty-six patients (13 men, 13 women) undergoing clinically-indicated non-i.v. and i.v. contrast abdominal/pelvic CT had dedicated QCT performed immediately following scans of the L1, L2, and L3 vertebral bodies. QCT was then performed on all three scans. A repeated measures analysis of variance model was used to analyze the data in order to compare noncontrast clinical CT with QCT and noncontrast clinical with contrast clinical CT.
  
  
  RESULTS
  The mean bone mineral density for the noncontrast clinical study was 98.51 (mg/cc) versus 90.56 (mg/cc) for QCT (p = 0.0003; 95% confidence interval: 3.90 to 13.71). There was no significant difference (p = 0.085) between QCT performed from non-i.v. and i.v. contrast clinical CT scans.
  
  
  CONCLUSIONS
  Bone densitometry can be performed from either non-i.v. or i.v. contrast clinical CT scans if a conversion factor is applied. This can be determined by utilizing a formula Daverage = -7.83 + (0.99 x NCaverage), where Daverage and NCaverage are the abbreviations of "dedicated" and "noncontrast clinical" BMD averaged over vertebral bodies L1-L3, respectively.
authors: Department of Radiology, Penn State University, Hershey 17033, USA. khopper@xray.hmc.psghs.edu
authors: K D
authors: KD
authors: Hopper
authors: M P
authors: MP
authors: Wang
authors: A R
authors: AR
authors: Kunselman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015519:Bone Density; D016001:Confidence Intervals; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D016014:Linear Models; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media