Granzyme B-positive primary gastric T-cell lymphoma: gastric T-cell lymphoma with the possibility of extrathymic T cell origin.
A case of primary gastric T-cell lymphoma, which was positive for granzyme B, is reported. The patient was a 47-year-old Japanese female who complained of a dull upper abdominal pain. Radiographic and endoscopic examinations revealed an ulcerative infiltrative lesion in her stomach. Following the confirmation of a high-grade malignant lymphoma, a distal gastrectomy with regional lymph nodal dissection was performed. The histology of the gastric lesion revealed a malignant lymphoma of the diffuse pleomorphic type without lymph nodal involvement. Immunohistochemistry revealed that the tumor cells were positive for LCA, CD3, TIA-1 and granzyme B, but were negative for CD4, CD8, CD56, CD30, L-26, EMA, TCR alpha/beta and TCR gamma/delta. Because the tumor cells showed T cell nature with cytotoxic activity proved by TIA-1 and granzyme B, and without evidence of further maturation of T cell, a malignant lymphoma originating from extrathymic-derived T cells was suggested.
Murata
T
T
Department of Pathology and Clinical Laboratories, JA Suzuka Hospital, Suzuka, Japan. zmurata@ztv.ne.jp
Nakamura
S
S
Oka
K
K
Kawakami
K
K
Kato
M
M
Imai
T
T
Nakayama
T
T
Kuroda
M
M
Nakano
H
H
Watanabe
M
M
Shiraishi
T
T
D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D053804:Granzymes; D006801:Humans; D007124:Immunoenzyme Techniques; D016411:Lymphoma, T-Cell, Peripheral / Q000737:chemistry / Q000201:enzymology / Q000473:pathology*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D012697:Serine Endopeptidases / Q000032:analysis / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000737:chemistry / Q000201:enzymology / Q000473:pathology*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases