[Does macular hole formation have a hormonal cause?].
OBJECTIVE
To establish the degree of supposed hormonal deficiency in estriadol (E2), gonadotrophins (LH, FSH), growth hormone (GH), insuline-like growth factor 1 (IGF-1) and to assess calcic-phosphatic metabolism in women with idiopathic macula holes as compared to (age-matched) controls.


METHODS
In 16 female patients aged 65-72, blood E2, LH, FSH, IGF-1 were determined. Serum and 24 h urine excretion calcium and phosphates as well as serum alkaline phosphatase activity were taken as markers of Ca/P metabolism. Bone densitometry was performed in all.


RESULTS
Mean actual serum hormone levels were: E2 < 15 pg/ml, LH--31 U/l, FSH--49 U/l, GH--0.1 ng/ml, IGF1--59 ng/ml. The markers of mineral metabolism did not show any abnormality: serum Ca--5.0 mEq/l, P--4.1 mg%, alkaline phosphatase 111 U/l, 24 h urine excretion Ca--121 mg/24 h, P--610 mg/24 h. Mean bone L2-L4 density fell within normal limits: 81% (z = -1.91).


CONCLUSIONS
In postmenopausal women with idiopathic macular holes, serum E2, LH, FSH bone metabolic markers and bone density are comparable to those found in women (of the same age group) free of macular holes. Women with macular holes are characterized by lower GH and IGF-1, which prompts further study.
Kmera-Muszyńska
M
M
Katedry i Kliniki Okulistyki II Wydziału Lekarskiego AM w Warszawie, Szpital Praski.
Zgliczyński
W
W
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density; D002118:Calcium / Q000097:blood / Q000652:urine; D005260:Female; D013006:Growth Hormone / Q000172:deficiency / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000378:metabolism; D010710:Phosphates / Q000097:blood / Q000652:urine; D017698:Postmenopause / Q000378:metabolism*; D012167:Retinal Perforations / Q000209:etiology* / Q000378:metabolism*
D015415:Biomarkers; D006728:Hormones; D010710:Phosphates; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D000469:Alkaline Phosphatase; D002118:Calcium