In vitro pharmacodynamic studies of activities of ketolides HMR 3647 (Telithromycin) and HMR 3004 against extracellular or intracellular Helicobacter pylori.
The pharmacodynamic properties of the ketolides HMR 3647 (telithromycin) and HMR 3004 were studied against Helicobacter pylori. Both ketolides showed a pronounced concentration-dependent killing, a significant postantibiotic effect, a long postantibiotic sub-MIC effect, and a reduction of intracellular H. pylori.
Gustafsson
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I
Department of Clinical Bacteriology, Department of Infectious Diseases, Uppsala University, Uppsala, Sweden.
Engstrand
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L
Cars
O
O
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002460:Cell Line; D004847:Epithelial Cells / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C105420:RU 64004; C106791:telithromycin