Tc-99m PMT whole-body scintigraphy for evaluated of therapeutic effect and for monitoring bone metastasis in a patient with hepatocellular carcinoma.
Detection of metastatic lesions by bone scintigraphy is highly sensitive but has a low rate of specificity. Often bone metastases from hepatocellular carcinoma are not detected by bone scintigraphy because of low uptake or a photopenic area in the tumor. In contrast, Tc-99m Sn-N-pyridoxy-5-methyltryptophan (Tc-99m PMT) whole-body scintigraphy reflects tumor viability, and the specificity of detection is so high that tumor structure can be shown well. Tc-99m PMT whole-body scintigraphy was helpful for evaluating the response to therapy and monitoring the course of the patient described here with bone metastasis from hepatocellular carcinoma.
Sueyoshi
K
K
Department of Radiology, Osaka Medical College, Takatuki-city, Japan. rad002@poh.osaka-med.ac.jp
Narabayashi
I
I
Doi
K
K
Takahashi
M
M
Komori
T
T
Tatsu
Y
Y
Tatsumi
T
T
Utunomiya
K
K
Uesugi
Y
Y
Adachi
I
I
Shimizu
T
T
D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000556:secondary*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D014364:Tryptophan / Q000031:analogs & derivatives*
D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C034836:technetium Tc 99m (Sn)-N-pyridoxyl-5-methyltryptophan; D014364:Tryptophan