Antiphospholipid antibodies and the endothelium.
This article reviews current understanding of the relationship between antiphospholipid antibodies and the endothelium. In vitro antiphospholipid antibodies produce endothelial cell activation. Clinical data in this area are scanty and worthy of future research, which could lead to new therapies in the management of antiphospholipid syndrome.
Hunt
B J
BJ
Departments of Hematology & Lupus Unit, Guy's & St. Thomas' Trust, London SE1 7EH, England. Beverley.Hunt@gstt.sthames.nhs.uk
Khamashta
M A
MA
D017152:Antibodies, Antiphospholipid / Q000276:immunology / Q000378:metabolism*; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D001161:Arteriosclerosis / Q000209:etiology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008074:Lipoproteins / Q000378:metabolism; D013927:Thrombosis / Q000209:etiology
D017152:Antibodies, Antiphospholipid; D000960:Hypolipidemic Agents; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor