[Genetics of asthma and atopy].
The genetics of asthma and atopy has made tremendous progresses over the last couple of years. It has been known for ages that allergies and asthma are concentrating within families. Modern genetics has pinpointed some gene areas such as 5q31.1, 6p21.3, 11q13, 12q15, 14q11.1 and 16p12. Much of the information available today has been fragmentary and not always confirmed. Alleles at multiple loci are likely to be involved and the ultimate picture is most likely determined by many genetic and environmental factors.
Demoly
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P
Maladies Respiratoires, INSERM U454, Hôpital Arnaud de Villeneuve, CHU de Montpellier. demoly@montp.inserm.fr
Bousquet
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D000483:Alleles; D001249:Asthma / Q000453:epidemiology / Q000235:genetics*; D001315:Australia / Q000453:epidemiology; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000235:genetics; D004739:England / Q000453:epidemiology; D004802:Eosinophilia / Q000453:epidemiology / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D014481:United States / Q000453:epidemiology