title: The class IV semaphorin CD100 plays nonredundant roles in the immune system: defective B and T cell activation in CD100-deficient mice.
abstract: The class IV semaphorin CD100/Sema4D differentially utilizes two distinct receptors: plexin-B1 in nonlymphoid tissues, such as brain and kidney, and CD72 in lymphoid tissues. We have generated CD100-deficient mice and demonstrated that they have functional defects in their immune system, without apparent abnormalities in other tissues. The number of CD5(+) B-1 cells was considerably decreased in the mutant mice, whereas conventional B cells and T cells appeared to develop normally. In vitro proliferative responses and immunoglobulin production were reduced in CD100-deficient B cells. The humoral immune response against a T cell-dependent antigen and in vivo priming of T cells were also defective in the mutant mice. These results demonstrate nonredundant and essential roles of CD100-CD72 interactions in the immune system.
authors: Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita Osaka 565-0871, Japan.
authors: W
authors: W
authors: Shi
authors: A
authors: A
authors: Kumanogoh
authors: C
authors: C
authors: Watanabe
authors: J
authors: J
authors: Uchida
authors: X
authors: X
authors: Wang
authors: T
authors: T
authors: Yasui
authors: K
authors: K
authors: Yukawa
authors: M
authors: M
authors: Ikawa
authors: M
authors: M
authors: Okabe
authors: J R
authors: JR
authors: Parnes
authors: K
authors: K
authors: Yoshida
authors: H
authors: H
authors: Kikutani
mesh_terms: D000818:Animals; D015703:Antigens, CD; D001402:B-Lymphocytes / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology; D007109:Immunity / Q000235:genetics; D008213:Lymphocyte Activation / Q000235:genetics* / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D039961:Semaphorins; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD; C093224:CD100 antigen; D008562:Membrane Glycoproteins; D039961:Semaphorins