title: Hereditary multiple exostoses and acute myeloid leukemia: an unusual association.
abstract: Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the presence of multiple exostoses. Three genetic loci have been identified, of which two (EXT1 and EXT2) have tumor suppressor activity. HME greatly increases the risk to develop sarcoma in the dysplastic tissue. The authors report an 8-year-old girl with HME who developed acute myeloblastic leukemia.
authors: Department of Pediatrics, Division of Hematology, Ankara University School of Medicine, Ankara, Turkey.
authors: S
authors: S
authors: Gözdaşoğlu
authors: Z
authors: Z
authors: Uysal
authors: A E
authors: AE
authors: Kürekçi
authors: S
authors: S
authors: Akarsu
authors: M
authors: M
authors: Ertem
authors: S
authors: S
authors: Fitöz
authors: A
authors: A
authors: Ikincioğullari
authors: S
authors: S
authors: Cin
mesh_terms: D000208:Acute Disease; D002648:Child; D005097:Exostoses, Multiple Hereditary / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D010375:Pedigree; D011859:Radiography