Helicobacter pylori vaccine strategies--triggering a gut reaction.
Helicobacter pylori causes peptic ulcer disease and some forms of gastric cancer; it is one of the most common chronic bacterial infections of humans. Although several prototype protein-based vaccines have shown promising results, they have not cleared infection and/or prevented reinfection. Nucleic acid vaccination offers a useful alternative to protein immunization, especially now that two complete H. pylori genome sequences are available, and facilitates the selection of antigenic targets.
Hatzifoti
C
C
Dept of Immunology, St Bartholomew's and the Royal London School of Medicine and Dentistry, 38 Little Britain, EC1A 7BE, London, UK.
Wren
B W
BW
Morrow
W J
WJ
D000276:Adjuvants, Immunologic; D000818:Animals; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D019470:Biolistics; D002648:Child; D002675:Child, Preschool; D005753:Gastric Mucosa / Q000276:immunology*; D005756:Gastritis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D016680:Genome, Bacterial; D016481:Helicobacter Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007223:Infant; D051379:Mice; D012008:Recurrence; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic