Diltiazem-mediated inhibition of sildenafil metabolism may promote nitrate-induced hypotension.
Khoury
V
V
Kritharides
L
L
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D017023:Coronary Angiography; D004110:Diltiazem / Q000009:adverse effects*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D009566:Nitrates / Q000009:adverse effects*; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000378:metabolism*; D010879:Piperazines / Q000009:adverse effects / Q000378:metabolism*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones
D009566:Nitrates; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D004110:Diltiazem