Circadian phase-shifted rats show normal acquisition but impaired long-term retention of place information in the water task.
It is thought that circadian rhythms may influence learning and memory processes. However, research supporting this view does not dissociate a mnemonic impairment from other performance deficits. Furthermore, published reports do not specify the type of memory system influenced by the circadian system. The present study assessed the effects of phase shifting on acquisition and expression of place navigation in the water maze, a task sensitive to hippocampal dysfunction. The results showed that phase-shifting circadian rhythms in rats impaired the expression of place information on a retention test but not initial acquisition or encoding of place information. These results suggest that disruption of circadian rhythms may impair consolidation of previously encoded hippocampal place information.
Devan
B D
BD
Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia 22030-4444, USA.
Goad
E H
EH
Petri
H L
HL
Antoniadis
E A
EA
Hong
N S
NS
Ko
C H
CH
Leblanc
L
L
Lebovic
S S
SS
Lo
Q
Q
Ralph
M R
MR
McDonald
R J
RJ
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis*; D011897:Random Allocation; D051381:Rats; D020318:Rats, Long-Evans; D012153:Retention, Psychology; D013037:Spatial Behavior / Q000502:physiology; D013997:Time Factors; D014867:Water
D014867:Water