Chronic graft-versus-host disease-related polymyositis as a cause of respiratory failure following allogeneic bone marrow transplant.
An unusual case of respiratory failure and dropped head syndrome as a complication of severe chronic graft-versus-host disease (GVHD)-related polymyositis is described. The patient required tracheostomy and mechanical ventilation but recovered following treatment with aggressive immunosuppression and intensive rehabilitation. The differential diagnoses of muscle weakness in the bone marrow transplant (BMT) patient and the dropped head syndrome are both discussed. To our knowledge, this is the first reported case of respiratory failure requiring mechanical ventilation occurring as a complication of GVHD-related polymyositis.
Leano
A M
AM
Department of Medicine, New England Medical Center, Tufts University School of Medicine, Tupper Research Institute, Boston, MA 02111, USA.
Miller
K
K
White
A C
AC
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D017285:Polymyositis / Q000150:complications*; D012131:Respiratory Insufficiency / Q000209:etiology*