title: Progressive deterioration of soft neurological signs in chronic schizophrenic patients.
abstract: OBJECTIVE
  Neurological signs are found to be increased in schizophrenia in cross-sectional studies. Whether they progress with time is an important issue in addressing the course of the illness.
  
  
  METHODS
  The current study investigated different groups of neurological signs in 43 stable chronic schizophrenic patients over a 3-year period using an operationalized instrument.
  
  
  RESULTS
  While symptoms and medication have remained largely unchanged in the 3-year period, significant increase in soft neurological signs (SNS) ('motor coordination', 'sensory integration' and 'disinhibition') has been observed. This contrasted with the stability of 'pyramidal', 'extrapyramidal', 'dyskinesia' and 'catatonia' signs. The increase in SNS appears not to be related to age, illness duration, symptoms or medication.
  
  
  CONCLUSIONS
  This finding suggests that SNS represent a marker sensitive to a possible late deterioration process in the course of a schizophrenic illness.
authors: Department of Psychiatry, University of Hong Kong, Queen Mary Hospital, Hong Kong.
authors: E Y
authors: EY
authors: Chen
authors: C L
authors: CL
authors: Kwok
authors: J W
authors: JW
authors: Au
authors: R Y
authors: RY
authors: Chen
authors: B S
authors: BS
authors: Lau
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000209:etiology*; D015999:Multivariate Analysis; D009460:Neurologic Examination; D011446:Prospective Studies; D012021:Reflex, Abnormal; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D013997:Time Factors