title: Improvement of peripheral neuropathy by testosterone in a patient with 48,XXYY syndrome.
abstract: The 48,XXYY syndrome is a form of hypergonadotropic hypogonadism, characterized by tall statures, aggressive behavior, mental retardation, and stasis changes reflecting vascular insufficiency. We report a 25-year-old male with this syndrome showing a peripheral neuropathy and stasis dermatitis which were both reversed by administration of testosterone. Electrophysiologic studies, plethysmography, and thermography indicated that this treatment improved nerve conductivity and peripheral circulation. We postulate that in 48,XXYY syndrome a decrease in testosterone may result in peripheral neuropathy via nerve ischemia.
authors: Department of Rehabilitation Medicine, Tokai University School of Medicine, Kanagawa, Japan.
authors: S
authors: S
authors: Izumi
authors: A
authors: A
authors: Tsubahara
mesh_terms: D000328:Adult; D004576:Electromyography; D006801:Humans; D007621:Karyotyping; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology*; D010991:Plethysmography; D017445:Skin Diseases, Vascular / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D013739:Testosterone / Q000627:therapeutic use*; D013817:Thermography
chemical_list: D013739:Testosterone