[Targeting of antitumor drugs with monoclonal antibodies].
About forty years ago, immuno-targeting of antitumor drugs has been addressed as a way to improve their selectivity towards tumor cells. Despite the wide display of researches to solve inherent problems within this approach, rare were the immuno-conjugates which reached the clinical level. In any case, none of them was introduced in chemotherapy. However, there was a renewal of activity for the last ten years, due, in part, to the access to very highly cytotoxic-containing immuno-conjugates such as those elaborated from maytansinoides, enediynes or intercalating agents CC1065. It was also due to the design of the Adept concept. This antibody-directed enzyme prodrug therapy is based upon the use of monoclonal antibody to target an enzyme at the tumor cell surface which ultimately is expected to selectively deliver an antitumor drug from a suitable inactive prodrug. In both cases, clinical trials are in progress and one can expect that, at least, some immuno-conjugates will be soon introduced in cancer chemotherapy.
Monneret
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C
Institut Curie, 26, rue d'Ulm, 75248 Paris Cedex 05.
Florent
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JC
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D006801:Humans; D000922:Immunotoxins / Q000627:therapeutic use*; D008453:Maytansine / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use; D011355:Prodrugs / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use
D000903:Antibiotics, Antineoplastic; D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000922:Immunotoxins; D019384:Nucleic Acid Synthesis Inhibitors; D011355:Prodrugs; D011994:Recombinant Proteins; D008453:Maytansine