Viral replication and the coactivators p300 and CBP.
Productive viral infection requires coordinate regulation of viral and cellular gene expression. Viruses of different classes have evolved different mechanisms to conform to, adapt to and exploit programs of cellular gene expression. Many viral gene products influence and respond to cellular signals that control differentiation and proliferation Transcriptional coactivators are central to the regulation of the expression of genes controlling these events. p300 and CBP are closely related coactivators that regulate the transcription of specific genes, modify chromatin structure and influence cell cycle progression. In this review, the different molecular interactions of proteins encoded by DNA tumor viruses and lentiviruses with these transcriptional coactivators and related cellular proteins are summarized.
Hottiger
M O
MO
Institute of Veterinary Biochemistry, The University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
Nabel
G J
GJ
D000818:Animals; D050882:CREB-Binding Protein; D002472:Cell Transformation, Viral; D004263:DNA Tumor Viruses / Q000235:genetics / Q000502:physiology*; D015967:Gene Expression Regulation, Viral; D051548:Histone Acetyltransferases; D006801:Humans; D016086:Lentivirus / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism; D056921:Nuclear Receptor Coactivator 3; D015534:Trans-Activators / Q000378:metabolism*; D014779:Virus Replication / Q000502:physiology*
D009687:Nuclear Proteins; D015534:Trans-Activators; D050882:CREB-Binding Protein; C494363:CREBBP protein, human; C494364:Crebbp protein, mouse; D051548:Histone Acetyltransferases; C538866:NCOA3 protein, human; C538867:Ncoa3 protein, mouse; D056921:Nuclear Receptor Coactivator 3