title: Gene transfer into the central nervous system using herpes simplex virus-1 vectors.
abstract: Manipulation of gene expression in developing or in mature central nervous systems (CNS) holds a promise for the resolution of many compelling neurobiological questions, including the feasibility of gene therapy to treat diseases of the brain. In this context, a number of viral vectors have been used in recent years to introduce and express genes into the CNS. This article discusses a gene transfer system based on the Herpes Simplex Virus-1 (HSV-1). We describe here the use of non-replicating, non-toxic HSV-1 vector, 8117/43, in a series of studies carried in our joint program. This vector proves further the utility of HSV-1 as a delivery vehicle to a number of distinct sites within the CNS.
authors: Department of Anatomy and Cell Biology, State University of New York, Buffalo, USA.
authors: S
authors: S
authors: Tabbaa
authors: C
authors: C
authors: Goulah
authors: R K
authors: RK
authors: Tran
authors: A
authors: A
authors: Lis
authors: R
authors: R
authors: Korody
authors: B
authors: B
authors: Stachowski
authors: J M
authors: JM
authors: Horowitz
authors: G
authors: G
authors: Torres
authors: E K
authors: EK
authors: Stachowiak
authors: D C
authors: DC
authors: Bloom
authors: M K
authors: MK
authors: Stachowiak
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D018259:Herpesvirus 1, Human; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013238:Stereotaxic Techniques; D001616:beta-Galactosidase / Q000032:analysis / Q000235:genetics*
chemical_list: D001616:beta-Galactosidase