Progesterone receptor coactivators.
Progesterone action is mediated by intracellular progesterone receptors that regulate target gene transcription. Recently, numerous proteins termed coactivators have been identified that are recruited by the liganded progesterone receptor and enhance receptor-dependent transactivation. Coactivators are a diverse group of molecules that bring multiple structural and enzymatic functions to the promoter. The existence of coactivators represents yet another level of regulation for progesterone receptor activation.
Rowan
B G
BG
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
O'Malley
B W
BW
D000818:Animals; D005260:Female; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000378:metabolism; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism*; D015534:Trans-Activators / Q000494:pharmacology; D014157:Transcription Factors / Q000494:pharmacology; D015533:Transcriptional Activation / Q000187:drug effects
D018160:Receptors, Cytoplasmic and Nuclear; D011980:Receptors, Progesterone; D015534:Trans-Activators; D014157:Transcription Factors