Prolonged prodrome, systemic vasculitis, and deafness in Cogan's syndrome.
Cogan's syndrome is a rare, multisystem disease which occurs predominantly in children and young adults. It was originally described as the combination of interstitial keratitis and audiovestibular disturbance, but other forms of ocular disease, as well as systemic vasculitis, have since been recognised as part of the syndrome. Diagnosis can be difficult if the various manifestations occur separately, but early recognition is important because prompt treatment may prevent deafness. Two cases are presented here illustrating the features of this disease, and providing histological evidence of systemic vasculitis in both.
Van Doornum
S
S
Rheumatology Unit, The Royal Melbourne Hospital, Parkville VIC 3050, Australia.
McColl
G
G
Walter
M
M
Jennens
I
I
Bhathal
P
P
Wicks
I P
IP
D000328:Adult; D005938:Glucocorticoids / Q000627:therapeutic use; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007500:Iritis / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome; D014657:Vasculitis / Q000175:diagnosis* / Q000188:drug therapy
D005938:Glucocorticoids; D011239:Prednisolone