Evolution of plasma homovanillic acid (HVA) levels during treatment in schizo-affective disorder.
1. Plasma Homovanillic Acid (p HVA) levels were measured by HPLC (high performance liquid chromatography) in 5 schizo-affective depressed patients receiving a standardized treatment. (lithium, chlorpromazine and clomipramine) during 4 weeks. 2. Four patients were pretreated, without a washout period. 3. No significant difference was observed between patients and normal controls at baseline. Under treatment, pHVA levels increased (p<0.02) with clinical improvement (MADRS and PANSS scores). 4. Although effects of medications prior to the study period were not controlled, these findings suggest that depressed schizo-affective patients may have normal pHVA levels that increase with clinical improvement, unlike schizophrenic patients whose increased pHVA concentrations decline with neuroleptic treatment.
Galinowski
A
A
University Clinic of Mental Health and Therapeutics, Sainte Anne Hospital (Paris), Cochin Port Royal Faculty of Medicine, France.
Castelnau
C
C
Spreux-Varoquaux
O
O
Bourdel
M C
MC
Olie
J P
JP
Loo
H
H
Poirier
M F
MF
D000293:Adolescent; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002746:Chlorpromazine / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D002997:Clomipramine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000097:blood* / Q000188:drug therapy* / Q000523:psychology
D000929:Antidepressive Agents, Tricyclic; D018692:Antimanic Agents; D014150:Antipsychotic Agents; D008094:Lithium; D002997:Clomipramine; D002746:Chlorpromazine; D006719:Homovanillic Acid