title: Direct ex vivo measurement of CD8(+) T-lymphocyte responses to human parvovirus B19.
abstract: Parvovirus B19 is a common human pathogen which can cause severe syndromes, including aplastic anemia and fetal hydrops. The mapping of the first parvovirus B19-derived CD8(+) T-lymphocyte epitope is described. This HLA-B35-restricted peptide derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.
authors: Department of Virology, Karolinska Institute, Stockholm, Sweden.
authors: T
authors: T
authors: Tolfvenstam
authors: A
authors: A
authors: Oxenius
authors: D A
authors: DA
authors: Price
authors: B L
authors: BL
authors: Shacklett
authors: H M
authors: HM
authors: Spiegel
authors: K
authors: K
authors: Hedman
authors: O
authors: O
authors: Norbeck
authors: M
authors: M
authors: Levi
authors: K
authors: K
authors: Olsen
authors: M
authors: M
authors: Kantzanou
authors: D F
authors: DF
authors: Nixon
authors: K
authors: K
authors: Broliden
authors: P
authors: P
authors: Klenerman
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015797:HLA-B35 Antigen / Q000502:physiology; D006801:Humans; D017493:Leukocyte Common Antigens / Q000032:analysis; D016732:Parvovirus B19, Human / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000276:immunology
chemical_list: D015797:HLA-B35 Antigen; D017361:Viral Nonstructural Proteins; D017493:Leukocyte Common Antigens