Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy.
Congenital afibrinogenaemia and hypofibrinogenaemia are rare disorders of haemostasis. In this case report the problems posed in the management of two patients with fibrinogen levels less than 0.1g L(-1) and who developed intracranial bleeding are considered. The value of fibrinogen concentrate and the role of prophylaxis is also discussed.
Parameswaran
R
R
Haemophilia Centre, St Bartholomew's and The London NHS Trust, Royal London Hospital, London, UK.
Dickinson
J P
JP
de Lord
S
S
Keeling
D M
DM
Colvin
B T
BT
D000328:Adult; D000347:Afibrinogenemia / Q000150:complications* / Q000151:congenital / Q000628:therapy; D005340:Fibrinogen / Q000008:administration & dosage; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008297:Male
D005340:Fibrinogen