Clinicopathological evaluation in non-episode biopsies of renal transplant allograft.
Histopathological findings in renal allograft with stable function remain unclear. We therefore performed non-episode biopsy in the long-surviving renal allograft to investigate the histopathological changes. Our data show that, although arteriolopathy is characteristic of drug-induced nephropathy, it is unrelated to dosage and concentration of cyclosporine or tacrolimus in non-episode biopsy. We evaluated therefore the clinicopathological findings of arteriolopathy in this study. Non-episode biopsy was defined as follows: as serum creatinine level lower than, 2.0 mg/dl and a urinary protein level lower than 500 mg/day. A total of 65 biopsy specimens were enrolled in this study as non-episode biopsy. Twenty-nine specimens revealed arteriolopathy. There were no statistically significant differences between arteriolopathy and dosage or concentration of cyclosporine or tacrolimus. Arteriolopathy in non-episode biopsy was related to time of biopsy, kidney age, hypertension, and hyperlipidemia, suggesting that it is important for graft survival to strictly control blood pressure and blood lipid level.
Toki
K
K
Department of Urology, Osaka University Medical School, Suita-City, Japan.
Kyo
M
M
Takahara
S
S
Hatori
M
M
Morozumi
K
K
Ichimaru
N
N
Tanaka
T
T
Wang
J D
JD
Permpongkosol
S
S
Miyamoto
M
M
Oka
K
K
Imai
E
E
Kyakuno
M
M
Nakamura
T
T
Kojima
Y
Y
Inoue
T
T
Kameoka
H
H
Ding
X Q
XQ
Kokado
Y
Y
Okuyama
A
A
D000328:Adult; D001160:Arterioles / Q000473:pathology; D001706:Biopsy; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection / Q000473:pathology*; D006085:Graft Survival; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D019520:Living Donors; D008297:Male; D017741:Survivors; D016559:Tacrolimus / Q000627:therapeutic use; D014184:Transplantation, Homologous; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D016572:Cyclosporine; D002784:Cholesterol; D003404:Creatinine; D016559:Tacrolimus