Herpes simplex virus infection induces replication of human immunodeficiency virus type 1.
Genital herpes has been associated with increased efficiency of the sexual transmission and enhanced replication of human immunodeficiency virus type 1 (HIV-1). In this study we demonstrate that exposure to infectious or heat-inactivated herpes simplex virus (HSV) type 1 or 2 virions increases HIV-1 expression in macrophages at least in part by inducing NF-kappaB activity. Neutralizing antibodies to the HSV glycoprotein gB or gD markedly attenuated these virion-mediated effects on HIV-1 expression in macrophages. Thus HSV infection of macrophages that reside in genital mucosal tissue induces HIV-1 replication in these cells. Our study may have implications for the management of patients who are coinfected with the two viruses.
Moriuchi
M
M
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.
Moriuchi
H
H
Williams
R
R
Straus
S E
SE
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D002467:Cell Nucleus / Q000235:genetics; D016325:HIV Long Terminal Repeat; D018023:HIV Seronegativity / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology*; D015497:HIV-1 / Q000502:physiology*; D018259:Herpesvirus 1, Human / Q000502:physiology*; D018258:Herpesvirus 2, Human / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology / Q000821:virology*; D016328:NF-kappa B / Q000378:metabolism; D012016:Reference Values; D014779:Virus Replication
D016328:NF-kappa B