title: Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells.
abstract: The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). A cell-to-cell adhesion assay showed that 3,5-dihydroxy-4'-methoxystilbene and 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucopyranoside as well as resveratrol blocked significantly TNF-alpha-inducing cell-cell adhesion between human umbilical vein endothelial cells (HUVEC) and THP-1 cells.
authors: K S
authors: KS
authors: Ahn
authors: J H
authors: JH
authors: Kim
authors: S R
authors: SR
authors: Oh
authors: S Y
authors: SY
authors: Ryu
authors: H K
authors: HK
authors: Lee
mesh_terms: D002460:Cell Line; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000187:drug effects*
chemical_list: D013267:Stilbenes; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1