title: Artificial antigen-presenting cells as a tool to exploit the immune 'synapse'.
abstract: Recent progress in molecular medicine has provided important tools to identify antigen-specific T cells. In most cases, the approach is based on oligomeric combinations of recombinant major histocompatibility complex-peptide complexes fixed to various rigid supports available for binding by the T-cell receptor. These tools have greatly increased our insight into mechanisms of immune responses mediated by CD8+ T cells. Examples of the diverse fields of application for this technology include immunization, viral infections and oral tolerance induction.
authors: Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0663, USA.
authors: B
authors: B
authors: Prakken
authors: M
authors: M
authors: Wauben
authors: D
authors: D
authors: Genini
authors: R
authors: R
authors: Samodal
authors: J
authors: J
authors: Barnett
authors: A
authors: A
authors: Mendivil
authors: L
authors: L
authors: Leoni
authors: S
authors: S
authors: Albani
mesh_terms: D017951:Antigen Presentation; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000008:administration & dosage*; D007108:Immune Tolerance; D007158:Immunologic Techniques; D008081:Liposomes; D010455:Peptides / Q000008:administration & dosage*; D014611:Vaccination / Q000379:methods
chemical_list: D000949:Histocompatibility Antigens Class II; D008081:Liposomes; D010455:Peptides