Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro.
To investigate the effect of pranlukast on leukotriene- induced airway mucosal epithelial dysfunction, samples of human nasal mucosa obtained during surgery for facial trauma were exposed to leukotriene C4 and/or D4 and observed on a TV screen magnified x 2,500. Leukotriene C4- and D4-induced ciliary inhibition and delayed mucosal surface alterations appeared several hours later. Pranlukast prevented both the mucosal epithelial cell dysfunction and the delayed epithelial cell alteration.
Hisamatsu
K
K
Department of Otorhinolaryngology, Surugadai Nihon University Hospital School of Medicine, Tokyo, Japan. kenhisa@med.nihon-u.ac.jp
Nakajima
M
M
D000328:Adult; D002478:Cells, Cultured; D002867:Chromones / Q000494:pharmacology*; D002923:Cilia / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D020024:Leukotriene Antagonists / Q000494:pharmacology*; D017997:Leukotriene C4 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D017998:Leukotriene D4 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D009297:Nasal Mucosa / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D002867:Chromones; D020024:Leukotriene Antagonists; D017997:Leukotriene C4; D017998:Leukotriene D4; C047681:pranlukast