A network of protein-protein interactions in yeast.
A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces cerevisiae has been performed, enabling the establishment of a single large network of 2,358 interactions among 1,548 proteins. Proteins of known function and cellular location tend to cluster together, with 63% of the interactions occurring between proteins with a common functional assignment and 76% occurring between proteins found in the same subcellular compartment. Possible functions can be assigned to a protein based on the known functions of its interacting partners. This approach correctly predicts a functional category for 72% of the 1,393 characterized proteins with at least one partner of known function, and has been applied to predict functions for 364 previously uncharacterized proteins.
Schwikowski
B
B
The Institute for Systems Biology, 4225 Roosevelt Way NE, Suite 200, Seattle, WA 98105, USA.
Uetz
P
P
Fields
S
S
D000465:Algorithms; D019295:Computational Biology; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D023281:Genomics; D011485:Protein Binding; D020543:Proteome; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D020798:Two-Hybrid System Techniques
D005656:Fungal Proteins; D020543:Proteome