The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function.
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.
Lanier
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LL
Dept of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143-0414, USA. lanier@itsa.ucsf.edu
Bakker
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AB
D048868:Adaptor Proteins, Signal Transducing; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics; D020816:Amino Acid Motifs; D000818:Animals; D001845:Bone Cysts / Q000201:enzymology / Q000235:genetics; D004792:Enzyme Precursors / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000378:metabolism* / Q000502:physiology; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D022423:Myeloid Cells / Q000378:metabolism* / Q000502:physiology; D009928:Organ Specificity; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology; D011971:Receptors, Immunologic / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D013045:Species Specificity; D000072377:Syk Kinase; D051746:ZAP-70 Protein-Tyrosine Kinase
D048868:Adaptor Proteins, Signal Transducing; D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C110546:TYROBP protein, human; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; C000606897:Syk protein, mouse; D051746:ZAP-70 Protein-Tyrosine Kinase; C497261:ZAP70 protein, human; C497262:Zap70 protein, mouse