Liver transplantation in patients over 60 years of age.
Liver transplantation was previously only offered to patients under 60 years of age. We have analyzed the outcome after acceptance on the waiting list and after liver transplantation of patients over 60 years old. A total of 150 patients over 60 years old were listed for a first liver transplantation during 1990-1998. The annual number increased throughout the period. Primary biliary cirrhosis, primary sclerosing cholangitis, and acute hepatic failure were the most frequent diagnoses. A total of 119 patients received a first liver allograft. The patient 1-year survival was 75% and 3-year survival 62%, which was not significantly lower (P = 0.21) than that of the younger patients. When correcting for year of transplantation, the survival was, however, moderately but significantly lower than among the younger patients. Survival among those > 65 years (n = 38) did not differ from that of patients 60-65 years of age (n = 81). We conclude that an increasing number of patients over 60 years old can be listed for liver transplantation and receive a liver allograft with highly satisfying results.
Bjøro
K
K
Department of Medicine A, Rikshospitalet, Oslo, Norway.
Höckerstedt
K
K
Ericzon
B G
BG
Friman
S
S
Hjortrup
A
A
Keiding
S
S
Schrumpf
E
E
Duraj
F
F
Olausson
M
M
Mäkisalo
H
H
Bergan
A
A
Kirkegaard
P
P
D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D003404:Creatinine / Q000097:blood; D006801:Humans; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology / Q000706:statistics & numerical data*; D008875:Middle Aged; D011517:Prothrombin Time; D012189:Retrospective Studies; D012537:Scandinavian and Nordic Countries; D012709:Serum Albumin / Q000032:analysis; D015996:Survival Rate; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D012709:Serum Albumin; D003404:Creatinine