New protopine alkaloids from Aristolochia constricta reduce morphine withdrawal in vitro.
The present study examines the effect of four new protopine alkaloids (1-4) isolated and purified from the aerial parts of Aristolochia constricta (Aristolichiaceae) on morphine withdrawal in vitro. The results of our experiments indicate that the pure compounds (1-4) significantly and in a concentration-dependent manner reduced the morphine withdrawal. The results of the present study suggest that these new protopine alkaloids may be potential anti-addictive agents.
Capasso
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A
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo di Fisciano, Salerno, 84084 Italy. annacap@unisa.it
De Tommasi
N
N
Rastrelli
L
L
De Simone
F
F
D000109:Acetylcholine / Q000502:physiology; D000470:Alkaloids / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D004484:Ecuador; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D000470:Alkaloids; D000701:Analgesics, Opioid; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine; D000109:Acetylcholine; C009093:protopine