Branching out to gain control: how the pre-TCR is linked to multiple functions.
How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCRbeta locus, and further differentiation.
Kruisbeek
A M
AM
Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. akru@nki.nl
Haks
M C
MC
Carleton
M
M
Michie
A M
AM
Zúñiga-Pflücker
J C
JC
Wiest
D L
DL
D000483:Alleles; D017209:Apoptosis; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D017637:Clonal Deletion; D005786:Gene Expression Regulation; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology*; D018448:Models, Immunological; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D021122:Protein Subunits; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology
D008562:Membrane Glycoproteins; D021122:Protein Subunits; D016693:Receptors, Antigen, T-Cell, alpha-beta; D014157:Transcription Factors; C090377:pre-T cell receptor alpha; D011494:Protein Kinases