title: Extramedullary T cell lymphoblastic transformation of chronic myeloid leukaemia successfully treated with matched unrelated donor bone marrow transplantation.
abstract: Chronic myeloid leukaemia (CML) inevitably terminates in blast crisis (BC) which is of myeloid phenotype in approximately two-thirds and B-lymphoid in one-third of patients. T cell BC is rare and associated with poor prognosis. We describe the case of a 48-year-old woman with extramedullary T cell lymphoblastic transformation. After treatment with combination chemotherapy she achieved a second chronic phase and underwent an allogeneic BMT from an HLA-matched unrelated donor. At 30 months follow-up she is still in complete molecular remission and in good clinical condition. We conclude that unrelated donor BMT should be considered as a therapeutic option for patients with extramedullary BC.
authors: Department of Medicine, Karl-Franzens University, Graz, Austria.
authors: U
authors: U
authors: Apfelbeck
authors: G
authors: G
authors: Hoefler
authors: P
authors: P
authors: Neumeister
authors: C
authors: C
authors: Fonatsch
authors: W
authors: W
authors: Linkesch
authors: H
authors: H
authors: Sill
mesh_terms: D001752:Blast Crisis / Q000628:therapy*; D016026:Bone Marrow Transplantation; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000473:pathology*