title: Molecular mimicry between HLA-DR alleles associated with rheumatoid arthritis and Proteus mirabilis as the Aetiological basis for autoimmunity.
abstract: Molecular mimicry is one of the pathological mechanisms proposed to explain the association between microorganisms and autoimmune diseases. This review deals with the association between bacteria and rheumatic diseases with a special emphasis on rheumatoid arthritis where upper urinary tract infection by Proteus mirabilis is the possible cause of this severe, arthritic condition. Prospective trials involving anti-Proteus therapy should be carried out.
authors: Division of Life Sciences, Infection and Immunity Group, King's College, 150 Stamford Street, London, UK.
authors: C
authors: C
authors: Wilson
authors: H
authors: H
authors: Tiwana
authors: A
authors: A
authors: Ebringer
mesh_terms: D000483:Alleles; D000907:Antibodies, Bacterial / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000382:microbiology*; D015551:Autoimmunity; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D018716:Molecular Mimicry; D011512:Proteus Infections / Q000150:complications / Q000276:immunology; D011513:Proteus mirabilis / Q000276:immunology*; D014552:Urinary Tract Infections / Q000150:complications / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D006684:HLA-DR Antigens