Increased diversity within the HLA-B*07 group: identification of the two novel alleles B*0709 and B*0710.
The identification of the two novel alleles, HLA-B*0709 and B*0710, is described. B*0709 differs from B*07021 by a nucleotide exchange at position 419 (A>C) which is located in exon 3. At the protein level the nucleotide exchange results in an amino acid residue difference (Tyr116Ser). The other newly detected allele, B*0710, differs from B*07021 by a nucleotide exchange at position 272 (A>G) which is located in exon 2. This nucleotide exchange also leads to an amino acid substitution (Tyr67Cys). The allogeneic potential in case of mismatch with other alleles of the B*07 group at bone marrow transplantation was assessed. The peptide motifs between B*0709 and B*0711 may be very similar and thus the alloreactive potential in case of mismatch may be low. In contrast, mismatches of B*0709 and B*0710 with other B*07 alleles are likely to stimulate alloreactive T cells.
Elsner
H A
HA
Department of Transfusion Medicine, Hannover Medical School, Germany.
Blasczyk
R
R
D000483:Alleles; D000595:Amino Acid Sequence; D014644:Genetic Variation; D015793:HLA-B7 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data
D015793:HLA-B7 Antigen