title: Folic acid supplementation.
abstract: Neural tube defects represent one of a limited number of congenital conditions for which primary prevention strategies are available. Despite strong clinical evidence to support the preventive effect of supplementary folic acid given prior to conception and continued throughout the first 12 weeks of pregnancy, there is limited recent epidemiological data to support the effectiveness of national folic acid supplementation programs. Whether folic acid fortification of staple foods will provide a more effective means of achieving further reductions in the prevalence rates for this condition remains open to question. Recent advances associating folic acid supplementation, hyperhomocysteinaemia and neural tube defects provide a new insight into the possible pathological mechanism of this and possibly other related congenital conditions.
authors: Royal Free and University College School of Medicine, University of London.
authors: S A
authors: SA
authors: Ali
authors: D L
authors: DL
authors: Economides
mesh_terms: D019587:Dietary Supplements; D005260:Female; D005492:Folic Acid; D005494:Folic Acid Deficiency / Q000517:prevention & control*; D006801:Humans; D009436:Neural Tube Defects / Q000517:prevention & control*; D011247:Pregnancy
chemical_list: D005492:Folic Acid