title: Conditioned place aversion to the "hangover" phase of acute ethanol administration in the rat.
abstract: The purpose of this study was to examine ethanol's delayed effects (termed hangover) using conditioned place testing. Four groups of rats received a single pairing of a distinctive environment (tactile and visual) 10 h after injection with ethanol (0, 2, 3, 4 g/kg, i.p. ) or saline in a counterbalanced design. Rats receiving 3 and 4 g/kg ethanol showed a conditioned place aversion to ethanol hangover. Conditioning 10 h after 0 or 2 g/kg ethanol did not produce a significant place preference or aversion. The results suggest that the hangover following an acute injection of high doses of ethanol (3-4 g/kg) produces a significant and dose-related conditioned place aversion in the rat.
authors: Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA. amorse@scripps.edu
authors: A C
authors: AC
authors: Morse
authors: G
authors: G
authors: Schulteis
authors: F A
authors: FA
authors: Holloway
authors: G F
authors: GF
authors: Koob
mesh_terms: D000818:Animals; D001348:Aversive Therapy; D003213:Conditioning, Psychological; D004777:Environment; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood; D007700:Kinetics; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000431:Ethanol