title: Magnetic resonance imaging appearance of metastatic Merkel cell carcinoma to the sacrum and epidural space.
abstract: Merkel cell carcinoma (MCC) is a rare malignant tumor of the skin and often is diagnosed histologically as lymphoma, melanoma and even metastatic small cell carcinoma of the lung (SCCL). Classified as a neuroendocrine tumor, clinically it originates in the head and neck region and may present with metastatic disease at the time of presentation [1]. Osseous involvement in the past has been described to involve regional facial bones only. We present the first reported MRI findings of distant osseous metastasis from a Merkel cell carcinoma to the lumbosacral spine with associated soft tissue and epidural involvement. Appropriate treatment and patient survival depend on prompt diagnostic imaging for establishment of metastatic disease. Previous reports have advocated CT for diagnosis and staging of distant metastases [2,3]. When spinal involvement is suspected, MRI may be a more suitable modality for assessment of the epidural space and appropriate staging and follow-up in such cases.
authors: Department of Diagnostic Radiology, Temple University Hospital, Philadelphia, PA, USA.
authors: S
authors: S
authors: Moayed
authors: C
authors: C
authors: Maldjianb
authors: R
authors: R
authors: Adam
authors: A
authors: A
authors: Bonakdarpour
mesh_terms: D000368:Aged; D001706:Biopsy; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D004428:Ear Neoplasms / Q000473:pathology; D004431:Ear, External / Q000473:pathology; D004824:Epidural Space; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012447:Sacrum; D012983:Soft Tissue Neoplasms / Q000473:pathology; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D013997:Time Factors; D014057:Tomography, X-Ray Computed