Diagnosis of defects in the type 1 cytokine pathway.
Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'high-output' interferon-gamma (IFN-gamma) pathway exhibit selective susceptibility to poorly pathogenic mycobacterial and salmonella infections. This review summarises the extended clinical spectrum seen in this group of patients and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway.
Lammas
D A
DA
MRC Centre for Immune Regulation, University of Birmingham, B15 2TT, Birmingham, UK. D.A.Lammas@bham.ac.uk
Drysdale
P
P
Ben-Smith
A
A
Girdlestone
J
J
Edgar
D
D
Kumararatne
D S
DS
D000328:Adult; D001424:Bacterial Infections / Q000175:diagnosis* / Q000276:immunology* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000172:deficiency* / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D020022:Genetic Predisposition to Disease; D006801:Humans; D007371:Interferon-gamma / Q000032:analysis / Q000172:deficiency / Q000235:genetics; D018664:Interleukin-12 / Q000032:analysis / Q000172:deficiency / Q000235:genetics; D009164:Mycobacterium Infections / Q000175:diagnosis / Q000276:immunology; D017471:Receptors, Interferon / Q000032:analysis; D018123:Receptors, Interleukin / Q000032:analysis / Q000502:physiology; D012480:Salmonella Infections / Q000175:diagnosis / Q000276:immunology
D016207:Cytokines; D017471:Receptors, Interferon; D018123:Receptors, Interleukin; D018664:Interleukin-12; D007371:Interferon-gamma