title: Analytical considerations for microdialysis sampling.
abstract: Adaptations in microdialysis probe designs have made it possible to obtain samples from the extracellular fluid of a variety of tissues with high temporal resolution. The resulting small volume samples, often with low concentration of the analyte(s) of interest, present a particular challenge to the analytical system. Rapid separations can be coupled on-line with microdialysis to provide near real-time data. By combining microdialysis sampling with a liquid chromatographic or capillary electrophoretic separation and a highly sensitive detection method, a separation-based sensor can be developed. Such sensors have been applied to the investigation of drug entities as well as to study endogenous analytes.
authors: Bioanalytical Systems, Inc., Kansas Research Laboratory, Lawrence, KS, USA.
authors: M I
authors: MI
authors: Davies
authors: J D
authors: JD
authors: Cooper
authors: S S
authors: SS
authors: Desmond
authors: C E
authors: CE
authors: Lunte
authors: S M
authors: SM
authors: Lunte
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary; D006801:Humans; D013058:Mass Spectrometry; D017551:Microdialysis