Saliva tannin interactions.
Many plant foods contain tannins, compounds that bind proteins, such as mammalian enzymes. Although described as tasteless, tannins can be detected orally by their astringency. However, the actual mechanism of oral detection and the effect of tannins on mastication and swallowing have been little investigated. Here, we show from in vitro tests that tannic acid, a common standard in tests used to detect tannins, significantly reduces the lubricating qualities of human saliva both by decreasing its viscosity and increasing friction, both factors lending support to the notion that astringency is a tactile phenomenon. From the literature, it is clear that this effect depends on the presence of salivary proline-rich proteins (PRP). In a mammalian context, ingestion of tannin-rich foods in a species with salivary PRP will be signalled by interference with bolus formation during mastication while the increase in friction may also be detectable and lead to increased tooth wear if the signal is ignored. In a human context, cross-cultural preferences for tannin-rich beverages such as tea, coffee and red wine at the end of meals may be explained by reduction in adhesion of food particles to the oral mucosa allowing their rapid oral clearance.
Prinz
J F
JF
Basic Medical Sciences, St Bartholomew's and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield, London, U.K. J.F.Prinz@mds.qmw.ac.uk
Lucas
P W
PW
D000328:Adult; D005260:Female; D017276:Friction; D006801:Humans; D008297:Male; D010455:Peptides / Q000378:metabolism*; D055232:Proline-Rich Protein Domains; D011485:Protein Binding; D012463:Saliva / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D013634:Tannins / Q000378:metabolism* / Q000494:pharmacology; D014783:Viscosity / Q000187:drug effects
D010455:Peptides; D012471:Salivary Proteins and Peptides; D013634:Tannins