[Immunology in medical practice. XXXV. Screening of suspected immunodeficiency: diagnostic protocols for patients with opportunistic or recurrent severe infections, wasting and failure to thrive].
With a multistage laboratory protocol immunodeficiencies can be efficiently identified. The article presents a diagnostic protocol that consists of three schemes. Scheme 1 describes the diagnostic protocol for the large group of patients with recurrent pulmonary and ENT-infections, where an antibody deficiency can occasionally be found. Scheme 2 presents the diagnostic protocol for the much smaller group of patients with opportunistic infections, wasting or failure to thrive. Several of these patients suffer from a severe T-lymphocyte disorder. Early diagnosis and treatment is important for the prognosis in these patients. Scheme 3 shows the diagnostic protocol for patients with recurrent infections of surface areas and deeper organs; these patients may suffer from a phagocyte disorder.
de Vries
E
E
Bosch Medicentrum, afd. Kindergeneeskunde, ME's-Hertogenbosch.
Kuijpers
T W
TW
van Tol
M J
MJ
van der Meer
J W
JW
Weemaes
C M
CM
van Dongen
J J
JJ
D000465:Algorithms; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology; D001424:Bacterial Infections / Q000175:diagnosis / Q000276:immunology; D002985:Clinical Protocols; D003937:Diagnosis, Differential; D005183:Failure to Thrive / Q000276:immunology*; D005820:Genetic Testing; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000276:immunology*; D007239:Infections / Q000175:diagnosis* / Q000276:immunology*; D008403:Mass Screening / Q000379:methods*; D009181:Mycoses / Q000175:diagnosis / Q000276:immunology; D009426:Netherlands; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology; D012008:Recurrence; D014777:Virus Diseases / Q000175:diagnosis / Q000276:immunology; D019282:Wasting Syndrome / Q000276:immunology*