Drug-related pemphigus and angiotensin converting enzyme inhibitors.
A 105-year-old woman developed pemphigus foliaceus. She had been on fosinopril, an angiotensin-converting enzyme inhibitor (ACE inhibitor) for 4 years. Anti-intercellular cement substance antibodies were positive with titre > 160. She died during admission of an unrelated illness. A 57-year-old man developed pemphigus vulgaris after 11 months treatment with quinapril. At 14 months after developing pemphigus, this man continues on prednisone and azathioprine. We speculate that these are cases of ACE-inhibitor-related pemphigus and we review ACE-inhibitor-related pemphigus.
Ong
C S
CS
Department of Dermatology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. search4@ozemail.com.au
Cook
N
N
Lee
S
S
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D017809:Fatal Outcome; D005260:Female; D005455:Fluorescent Antibody Technique; D017328:Fosinopril / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D011379:Prognosis; D018570:Risk Assessment
D000806:Angiotensin-Converting Enzyme Inhibitors; D017328:Fosinopril