title: SATSCOM--Selective amobarbital test intraarterial SPECT coregistered to MRI: description of a method assessing selective perfusion.
abstract: For evaluation of potential functional deficits, an intraarterial amobarbital test is performed prior to neurosurgical or neuroradiological interventions. To visualize individual amobarbital perfusion patterns, simultaneous injection of (99m)Tc-HMPAO was performed previously. The present study describes for the first time a method of coregistration of intraarterial SPECT during selective amobarbital test to MRI. Three patients undergoing selective amobarbital test of the posterior cerebral artery were included. SATSCOM (Selective amobarbital test intraarterial SPECT coregistered to MRI) was performed by skull extraction in SPECT and MRI followed by surface matching. In all three patients, SATSCOM revealed accurate matching results. With this functional-anatomical mapping, suppression of higher cortical functions can be correlated to anatomical regions. Furthermore, a more precise mapping of amobarbital effect improves planning invasive interventions, particularly those close to eloquent areas.
authors: Department of Epileptology, Bonn University Medical School, Sigmund-Freud-Strasse 25, Bonn, 53105, Germany.
authors: J
authors: J
authors: von Oertzen
authors: E
authors: E
authors: Klemm
authors: H
authors: H
authors: Urbach
authors: M
authors: M
authors: Kurthen
authors: A
authors: A
authors: de Greiff
authors: D B
authors: DB
authors: Linke
authors: H J
authors: HJ
authors: Biersack
authors: C E
authors: CE
authors: Elger
mesh_terms: D000328:Adult; D000654:Amobarbital; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000601:surgery; D004292:Dominance, Cerebral / Q000502:physiology*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006624:Hippocampus / Q000098:blood supply / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007269:Injections, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008297:Male; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D011183:Postoperative Complications / Q000503:physiopathology; D011612:Psychosurgery; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000098:blood supply / Q000601:surgery; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019690:Technetium Tc 99m Exametazime; D000654:Amobarbital