Immune suppression and skin cancer development: regulation by NKT cells.
Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo.
Moodycliffe
A M
AM
Department of Immunology, University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA.
Nghiem
D
D
Clydesdale
G
G
Ullrich
S E
SE
D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D018949:Antigens, CD1 / Q000235:genetics / Q000378:metabolism; D005260:Female; D006968:Hypersensitivity, Delayed; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009381:Neoplasms, Radiation-Induced / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014466:Ultraviolet Rays / Q000009:adverse effects
D000941:Antigens; D018949:Antigens, CD1