title: [Chlamydia infection and peripartum dilated cardiomyopathy in Niger].
abstract: Peripartum cardiac failure due to cardiomyopathy is common in sub-saharan Africa. The etiology is unknown. This study was performed in Niger to assess a possible relationship between peripartum cardiomyopathy and Chlamydia. A total of 50 African women presenting peripartum cardiomyopathy underwent testing for infection by Chlamydia pneumoniae, Chlamydia trachomatis, and Chlamydia psittaci. The inclusion criteria were cardiac failure during the last three months of pregnancy or first 6 months postpartum with echocardiographic evidence of dilated cardiomyopathy. Similar testing was carried out in a control group of 25 African women from the same geographical location without cardiac disease. Detection of specific IgG, IgA and IgM antibodies was performed using the microimmunofluorescence technique. The cut-off values were > or = 1/32 for specific IgG antibody and > or = 1/16 for specific IgA and IgM antibody. Statistical comparison of the patient and control groups was achieved using the chi 2 test. For Chlamydia pneumoniae, 48 patients (96 p. 100) versus 20 controls (80 p. 100) controls were positive for IgG antibodies (p < 0.025) and 39 patients (80 p. 100) versus 14 controls (56 p. 100) were positive for IgA antibodies (p < 0.05). No patient or control demonstrated IgM antibodies for Chlamydia pneumoniae. For Chlamydia trachomatis and Chlamydia psittaci, differences in positive rates were not statistically significant. This is the first study demonstrating infection in patients with peripartum cardiomyopathy. The possible role of Chlamydia pneumoniae is discussed.
authors: Université de Bretagne Occidentale, Brest et de la Biobanque de Picardie, France. Arnaud.Cenac@univ-brest.fr
authors: A
authors: A
authors: Cenac
authors: A
authors: A
authors: Djibo
authors: J M
authors: JM
authors: Sueur
authors: C
authors: C
authors: Chaigneau
authors: J
authors: J
authors: Orfila
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*; D002692:Chlamydia trachomatis / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D002691:Chlamydophila psittaci / Q000276:immunology; D004452:Echocardiography; D005260:Female; D005455:Fluorescent Antibody Technique / Q000379:methods; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D009548:Niger; D011644:Puerperal Disorders / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology*
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M