Telomerase is a strong indicator for assessing the proneness to progression in neuroblastomas.
BACKGROUND
As traditional parameters do not ensure completely accurate prognostic grouping in neuroblastoma (NB), new molecular markers are needed for assessing the individual patient's prognosis more precisely.
Based on 133 NB, we show that telomerase activity (TA) is a powerful, independent prognostic marker for all stages and is capable of differentiating between good and poor outcome in putative 'favorable' clinical or biological subgroups of NB patients. Analysis of gene and protein expression of telomerase subunits suggests that the presence or absence of TA in NB is strongly correlated with expression levels of both the catalytic subunit hTERT and the internal RNA component (hTR).
Poremba
C
C
Gerhard-Domagk-Institute of Pathology, Westfälische Wilhelms-University, Münster, Germany. poremba@uni-muenster.de
Hero
B
B
Heine
B
B
Scheel
C
C
Schaefer
K L
KL
Christiansen
H
H
Berthold
F
F
Kneif
S
S
Stein
H
H
Juergens
H
H
Boecker
W
W
Dockhorn-Dworniczak
B
B
D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007223:Infant; D008297:Male; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000201:enzymology* / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D019098:Telomerase / Q000235:genetics / Q000378:metabolism*
D019098:Telomerase