Effects of carvedilol on heart rate and blood pressure variability in subjects with chronic heart failure.
In this study we observed that carvedilol administration to patients with heart failure improves hemodynamic function, baroreflex sensitivity, and heart rate variability. These findings contribute to improvement in survival in such patients.
Piccirillo
G
G
Dipartimento di Scienze dell'Invecchiamenti, Università La Sapienza, Rome, Italy. piccirillog@uniroma1.it
Luparini
R L
RL
Celli
V
V
Moisè
A
A
Lionetti
M
M
Marigliano
V
V
Cacciafesta
M
M
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000465:Algorithms; D000704:Analysis of Variance; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D002302:Cardiac Output / Q000187:drug effects; D002311:Cardiomyopathy, Dilated / Q000150:complications; D000077261:Carvedilol; D004562:Electrocardiography / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010919:Placebos; D011412:Propanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D012044:Regression Analysis; D012119:Respiration / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects; D015996:Survival Rate; D014655:Vascular Resistance / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D010919:Placebos; D011412:Propanolamines; D000077261:Carvedilol