Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome.
Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 microM), a metabolite of the dopamine oxidative pathway, was found to down regulate the expression of angiotensin receptor mRNA in RCSN3 cells by 83% (p < 0.05).
Dagnino-Subiabre
A
A
Program of Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago.
Marcelain
K
K
Arriagada
C
C
Paris
I
I
Caviedes
P
P
Caviedes
R
R
Segura-Aguilar
J
J
D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D008058:Dihydrolipoamide Dehydrogenase / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D045563:Indolequinones; D007211:Indoles / Q000494:pharmacology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011945:Receptors, Angiotensin / Q000235:genetics* / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism*; D014158:Transcription, Genetic / Q000187:drug effects
D045563:Indolequinones; D007211:Indoles; D012333:RNA, Messenger; D011945:Receptors, Angiotensin; D000804:Angiotensin II; C091584:aminochrome 1; D008058:Dihydrolipoamide Dehydrogenase