[The association and linkage analysis between the FcgammaR II a-131 and system lupus erythematosus].
OBJECTIVE
To shed light on the relationship between FcgammaR II a-131 and systemic lupus erythematosus(SLE) in southern Chinese Han population.


METHODS
A population-based and family-based study was carried out. FcgammaR II a-131 of each subject was measured by using PCR-allele specific oligonucleotide hybridization(ASO) method.


RESULTS
(1) The distribution of FcgammaR II A-131 genotype in cases is significantly different from that in controls (P<0.05). So is the frequency of FcgammaR II aR-131 allele (P < 0.01) which suggests that subjects who have R131 allele tend to be more susceptible to SLE. The subjects with R/R131 homozygous genotype have a higher risk of suffering from SLE. (2) The distribution of FcgammaR II a-131 varies in different races, with identical distribution type among Chinese and Japanese. (3) The results of family-based association analysis and transmitted/disequilibrium test(TDT) suggest that there is not any linkage evidence between FcgammaR II a-131 and SLE. Possibly, the sample size was too small to get positive result.


CONCLUSIONS
This study suggests that FcgammaR II a-131 is a major factor predisposing to the development of SLE in southern Chinese Han population.
Ni
P
P
Department of Epidemiology, Shanghai Medical University, Shanghai, 200032 P.R.China.
Shen
F
F
Meng
W
W
Jiang
F
F
Feng
S
S
D000483:Alleles; D002681:China / Q000208:ethnology; D008040:Genetic Linkage; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
D017452:Receptors, IgG