Exhaled nitric oxide: a novel biomarker of adverse respiratory health effects in epidemiological studies.
The sampling of exhaled breath is a noninvasive procedure that can be performed easily in adults, children, and patients with respiratory disease. Several studies have demonstrated increased exhaled nitric oxide in patients with pulmonary disease, including asthma. In addition, exhaled nitric oxide may be an elegant tool for monitoring of environmental health effects of air pollution and the prevalence of atopy in epidemiological surveys. Recent literature about exhaled nitric oxide is presented in this article. Technical, physiological, and behavioral confounding factors of exhaled nitric oxide measurement are outlined.
van Amsterdam
J G
JG
Laboratory of Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
Nierkens
S
S
Vos
S G
SG
Opperhuizen
A
A
van Loveren
H
H
Steerenberg
P A
PA
D015415:Biomarkers / Q000032:analysis; D001944:Breath Tests; D015986:Confounding Factors, Epidemiologic; D004784:Environmental Monitoring / Q000379:methods; D004785:Environmental Pollutants / Q000009:adverse effects / Q000032:analysis*; D004812:Epidemiologic Methods; D062665:Epidemiological Monitoring; D006801:Humans; D008019:Life Style; D008171:Lung Diseases / Q000175:diagnosis* / Q000209:etiology; D009569:Nitric Oxide / Q000032:analysis*; D012680:Sensitivity and Specificity
D015415:Biomarkers; D004785:Environmental Pollutants; D009569:Nitric Oxide