TMC-89A and B, new proteasome inhibitors from streptomyces sp. TC 1087.
Koguchi
Y
Y
Department of Basic Technology, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
Nishio
M
M
Suzuki
S
S
Takahashi
K
K
Ohnuki
T
T
Komatsubara
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003546:Cysteine Endopeptidases; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*; D009842:Oligopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D004852:Epoxy Compounds; D009097:Multienzyme Complexes; D009842:Oligopeptides; C417144:TMC 89A; C417145:TMC 89B; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex