Analgesic and antiinflammatory activities of an extract from Parkia biglobosa used in traditional medicine in the Ivory Coast.
In the Ivory coast, Parkia biglobosa (Mimosaceae) is used in traditional medicine as an analgesic drug, especially against dental pain. Of the three extracts obtained from the plant bark, the hexane fraction was studied to determine its analgesic and/or antiinflammatory activities. The results show that this extract possesses a marked analgesic activity when evaluated with the abdominal writhing test in mice, but, like paracetamol, was ineffective with the hot-plate method, a feature suggesting a peripheral mechanism of action. This activity was accompanied by an antiinflammatory effect, somewhat weaker than the analgesic one.
Kouadio
F
F
Faculté de Chirurgie Dentaire, L.S.O. de la Faculté des Sciences et Techniques et Faculté de Pharmacie de l'Université de Nantes, 1 rue Gaston Veil, 44035 Nantes Cédex, France.
Kanko
C
C
Juge
M
M
Grimaud
N
N
Jean
A
A
N'Guessan
Y T
YT
Petit
J Y
JY
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D007560:Cote d'Ivoire; D004487:Edema / Q000188:drug therapy; D006358:Hot Temperature; D006801:Humans; D008297:Male; D016488:Medicine, African Traditional; D051379:Mice; D010146:Pain / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage; D014197:Trees
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013755:Tetradecanoylphorbol Acetate