title: Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains.
abstract: From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.
authors: Department of Microbiology and Immunology, University of Leicester, Alderley Edge, United Kingdom.
authors: N A
authors: NA
authors: Gingles
authors: J E
authors: JE
authors: Alexander
authors: A
authors: A
authors: Kadioglu
authors: P W
authors: PW
authors: Andrew
authors: A
authors: A
authors: Kerr
authors: T J
authors: TJ
authors: Mitchell
authors: E
authors: E
authors: Hopes
authors: P
authors: P
authors: Denny
authors: S
authors: S
authors: Brown
authors: H B
authors: HB
authors: Jones
authors: S
authors: S
authors: Little
authors: G C
authors: GC
authors: Booth
authors: W L
authors: WL
authors: McPheat
mesh_terms: D000818:Animals; D016470:Bacteremia / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006183:H-2 Antigens / Q000235:genetics; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009504:Neutrophils / Q000276:immunology; D011008:Pneumococcal Infections / Q000235:genetics / Q000276:immunology*; D013045:Species Specificity
chemical_list: D006183:H-2 Antigens