Eradication of hepatitis C virus 1b by interferon in a health care worker with acute hepatitis following needlestick transmission from a patient with chronic hepatitis C unresponsive to interferon.
Hepatitis C virus (HCV) was successfully eradicated by a short course of interferon (IFN) therapy in a nurse with acute HCV infection from a needlestick accident. The source patient had chronic hepatitis C and was a nonresponder to IFN therapy. The HCV genotype was 1b in patients, and a single point mutation (H-->R in amino acid 2218) was observed in the IFN sensitivity-determining region of the nonstructural 5A gene, in comparison with sequences of HCV-J, in HCV RNA from both the source patient (before and after IFN therapy) and the recipient (before IFN therapy). Though the strain transmitted was believed to be IFN-resistant in the patient with chronic hepatitis, the patient with acute hepatitis had a sustained response.
Toyoda
H
H
Dept. of Gastroenterology, Fujita Health University, School of Medicine, Aichi, Japan.
Sakamoto
H
H
Mizuno
T
T
Horiguchi
Y
Y
Nakano
H
H
D000208:Acute Disease; D005260:Female; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000628:therapy* / Q000635:transmission*; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional; D007372:Interferons / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016602:Needlestick Injuries / Q000150:complications*; D009726:Nurses
D007372:Interferons