title: Potent in vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)quinoline derivatives.
abstract: A novel structural class of antibacterials, 2-(1H-indol-3-yl)quinolines, effective against methicillin-resistant Staphylococcus aureus (MRSA), was discovered from a combinatorial library. A structure-activity relationship (SAR) study was conducted to determine the pharmacophore and increase the potency of these compounds. Compounds were prepared that had minimum inhibitory concentrations (MICs) < 1.0 microg/mL against MRSA and retained activity against two strains of glycopeptide intermediate-resistant S. aureus (GISA).
authors: Sepracor Inc., Marlborough, MA 01752, USA.
authors: M Z
authors: MZ
authors: Hoemann
authors: G
authors: G
authors: Kumaravel
authors: R L
authors: RL
authors: Xie
authors: R F
authors: RF
authors: Rossi
authors: S
authors: S
authors: Meyer
authors: A
authors: A
authors: Sidhu
authors: G D
authors: GD
authors: Cuny
authors: J R
authors: JR
authors: Hauske
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles; D011804:Quinolines