Tumor growth-promoting properties of macrophage migration inhibitory factor (MIF).
First identified nearly 40 years ago, macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine and is an essential component of immune and inflammatory responses. Recent studies suggest that MIF may also contribute to multiple aspects of tumor progression and neoplasia. This review will attempt to summarize these findings focusing on MIF's ability to modulate cell proliferation, tumor angiogenesis and tumor suppressor activity.
Mitchell
R A
RA
The Picower Institute for Medical Research, NY, New York 10030, USA.
Bucala
R
R
D000818:Animals; D002455:Cell Division; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D016158:Genes, p53; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D009369:Neoplasms / Q000209:etiology*; D009389:Neovascularization, Pathologic / Q000209:etiology
D008263:Macrophage Migration-Inhibitory Factors; D017868:Cyclic AMP-Dependent Protein Kinases; D020928:Mitogen-Activated Protein Kinases