title: Synthesis and antiproliferative activity of benzocyclobutacarbazol derivatives. A new class of potential antitumor agents.
abstract: Several benzocyclobutacarbazol derivatives were synthesized and evaluated for their potential cytotoxic properties. A number of these compounds exhibited significant antiproliferative activity with concomitant interaction with the cell cycle and represent a new class of potential anticancer agents.
authors: Institut de Chimie Organique et Analytique, associé au CNRS, Université d'Orléans, France.
authors: S
authors: S
authors: Graf-Christophe
authors: C
authors: C
authors: Kuehm-Caubère
authors: P
authors: P
authors: Renard
authors: B
authors: B
authors: Pfeiffer
authors: A
authors: A
authors: Pierré
authors: S
authors: S
authors: Léonce
authors: P
authors: P
authors: Caubère
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D003503:Cyclobutanes