title: Cellular mechanisms of netrin function: long-range and short-range actions.
abstract: Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional cues that act as an attractant for some cell types and as a repellent for others. Several lines of evidence suggest that two classes of receptors, the deleted in colorectal cancer (DCC) family and the UNC-5 family, mediate the attractant and repellent response to netrin. Although netrins were first identified as diffusible long-range cues for developing axons, recent findings provide evidence that they also function as short-range cues close to the surface of the cells that produce them. This short-range function of netrin contributes to guiding neurite outgrowth and mediating cell-cell interactions during development and perhaps also in adults.
authors: Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, QC, Canada. mddy@musica.mcgill.ca
authors: T E
authors: TE
authors: Kennedy
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D017173:Caenorhabditis elegans / Q000235:genetics / Q000648:ultrastructure; D029742:Caenorhabditis elegans Proteins; D002465:Cell Movement; D004058:Diffusion; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D019143:Evolution, Molecular; D005136:Eye Proteins / Q000502:physiology; D005326:Fetal Proteins / Q000502:physiology; D016163:Genes, DCC; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008959:Models, Neurological; D005810:Multigene Family; D009124:Muscle Proteins / Q000502:physiology; D009414:Nerve Growth Factors / Q000235:genetics / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D000075386:Netrin Receptors; D000075388:Netrin-1; D000075385:Netrins; D009469:Neuromuscular Junction / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000502:physiology; D013045:Species Specificity; D013268:Stimulation, Chemical; D025521:Tumor Suppressor Proteins
chemical_list: D029742:Caenorhabditis elegans Proteins; D005136:Eye Proteins; D005326:Fetal Proteins; D015801:Helminth Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D009124:Muscle Proteins; C498815:NTN4 protein, human; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D000075386:Netrin Receptors; D000075385:Netrins; C416214:Ntn4 protein, mouse; D011956:Receptors, Cell Surface; D017978:Receptors, Growth Factor; D025521:Tumor Suppressor Proteins; C119569:netrin-3; C077588:UNC-5 protein, C elegans; D000075388:Netrin-1; C088894:netrin-2