Review article: the role of non-acid reflux in gastro-oesophageal reflux disease.
The role of acid in the pathogenesis of gastro-oesophageal reflux disease (GERD) has been extensively studied and is well accepted. The role, if any, of non-acid reflux, in particular duodenogastro-oesophageal reflux, is much debated. The availability of new technology to detect non-acid reflux has heightened interest in this question. This article reviews the following: How do we define non-acid reflux? Does duodenogastro-oesophageal reflux (alone or in combination) cause oesophageal injury, symptoms or both? What is its role in complicated GERD? What methods are available to assess non-acid reflux? Does non-acid reflux need treatment and if so what modalities are available?
Katz
P O
PO
Department of Medicine, Graduate Hospital, Philadelphia, USA. pkatz19512@aol.com
D000818:Animals; D001471:Barrett Esophagus / Q000209:etiology; D001647:Bile Acids and Salts / Q000633:toxicity; D001663:Bilirubin / Q000032:analysis; D017097:Electric Impedance; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration
D001647:Bile Acids and Salts; D001663:Bilirubin