Increased incidence of trisomy 8 in acute myeloid leukemia with skin infiltration (leukemia cutis).
Anecdotal literature reports and the authors' own observations suggest an association between chromosome 8 aneuploidy and leukemia cutis. The authors investigated this potential association by using fluorescence in situ hybridization (FISH) directly on skin infiltrates in a series of 11 patients with acute monocytic leukemia (AML). Seven of the 11 patients were aneuploid for chromosome 8 by FISH which was confirmed by dual color hybridization. Six of these seven patients were AML-M4 or M5 and one was M1. The majority of the cases with leukemia cutis expressed CD4 (90% of cases), CD14 (60%), and/or CD56 (50%) in bone marrow leukemic cells. The data show the utility of examination of skin infiltrates by FISH for the detection of trisomy 8 in leukemia cutis. They also suggest the importance of trisomy 8 as a factor in predisposition to skin infiltration in AML.
Sen
F
F
Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Zhang
X X
XX
Prieto
V G
VG
Shea
C R
CR
Qumsiyeh
M B
MB
D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D015994:Incidence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D017254:Leukemic Infiltration / Q000235:genetics*; D008297:Male; D012189:Retrospective Studies; D012867:Skin / Q000473:pathology*; D014314:Trisomy / Q000235:genetics*