Allosterically controllable ribozymes with biosensor functions.
The concept of allosteric regulation has already been exploited in the creation of artificial ribozymes and the activities of certain ribozymes can be controlled allosterically by specific effectors. Ribozymes with such properties are in the spotlight as biosensors. Such artificial allosterically regulated ribozymes have potential utility as nucleic-acid-based biosensors.
Kuwabara
T
T
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Hongo, 113-8656, Tokyo, Japan.
Warashina
M
M
Taira
K
K
D015374:Biosensing Techniques; D015195:Drug Design; D011487:Protein Conformation; D016337:RNA, Catalytic / Q000737:chemistry*
D016337:RNA, Catalytic