title: Intracortical inhibitory circuits and sensory input: a study with transcranial magnetic stimulation in humans.
abstract: We compared intracortical inhibition (ICI) following paired transcranial magnetic stimulation (TMS) (interstimulus interval, ISI: 3 ms) and the inhibition of motor evoked potentials (MEPs) to TMS induced by stimulation of the median nerve (ISI: 200 ms) in six normal subjects. MEPs evoked by focal TMS were recorded in the relaxed opponens pollicis muscle and the size of the conditioned responses was expressed as a percentage of the size of the non-conditioned responses. Maximal ICI, ranging from 4 to 40%, and inhibition after median nerve stimulation, ranging from 11 to 68%, were significantly correlated. The results suggest that both phenomena are possibly mediated by the same gamma aminobutyric acid-ergic (GABAergic) inhibitory circuits and that afferent inputs to the cortex may contribute to their physiological activation.
authors: Department of Neurological Sciences and Vision, University of Genoa, Via de Toni, 16132, Genoa, Italy.
authors: C
authors: C
authors: Trompetto
authors: A
authors: A
authors: Buccolieri
authors: G
authors: G
authors: Abbruzzese
mesh_terms: D000328:Adult; D000368:Aged; D004558:Electric Stimulation; D055590:Electromagnetic Phenomena; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*