title: The effect of anticonvulsant drugs on blood levels of methotrexate.
abstract: The reduced bioavailability of chemotherapeutic agents is one of the reasons that explains the limited efficacy of adjuvant chemotherapy in high grade glioma patients. We report how even the results of high dose sequential chemotherapy can be influenced by antiepileptic drugs.
authors: Department of Neurology, Niguarda Cà-Granda Hospital, Milan, Italy. mauriva@tiscalinet.it
authors: M
authors: M
authors: Riva
authors: G
authors: G
authors: Landonio
authors: C A
authors: CA
authors: Defanti
authors: S
authors: S
authors: Siena
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D001682:Biological Availability; D001932:Brain Neoplasms / Q000097:blood / Q000188:drug therapy*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy; D017024:Chemotherapy, Adjuvant; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004347:Drug Interactions; D005260:Female; D005910:Glioma / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008727:Methotrexate / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D003577:Cytochrome P-450 Enzyme System; D002955:Leucovorin; D008727:Methotrexate