Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis.
In the SMXA recombinant inbred (RI) strains, we measured body weight, blood insulin and lipid (triglyceride, total cholesterol and phospholipid) levels in each strain. In the five traits, mean values of substrains varied remarkably and showed a continuous spectrum of distribution, suggesting control by multiple genes at distinct loci for each trait. We also screened for quantitative trait loci (QTLs) involved in the five traits. Suggestive QTLs for body weight (Chromosomes 1 and 6), insulin (Chromosomes 1, 3, 10 and 17), triglyceride (Chromosomes 4 and 11) and phospholipid (Chromosome 18) levels were detected. The SMXA RI strains are unique tools for analyzing genetic factors that influence body weight, blood insulin and lipids levels.
Anunciado
R V
RV
Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
Ohno
T
T
Mori
M
M
Ishikawa
A
A
Tanaka
S
S
Horio
F
F
Nishimura
M
M
Namikawa
T
T
D000818:Animals; D001835:Body Weight; D002874:Chromosome Mapping; D008040:Genetic Linkage; D007178:Inbreeding; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D051379:Mice; D008815:Mice, Inbred Strains / Q000097:blood*; D020412:Multifactorial Inheritance; D019655:Quantitative Trait, Heritable; D011995:Recombination, Genetic
D007328:Insulin; D008055:Lipids