title: [Cardioprotective effect of glycyram in myocardial damage induced by isadrine].
abstract: Experiments on rats with isadrine induced myocardial disorder showed that glycyrram reduces the extent of myocardial inflammatory edema, inhibits an increase in the level of marker enzymes (creatine kinase, lactate dehydrogenade, asparatate aminotransferase) in the blood serum, prevents a decrease in the myocardial glycogen and an increase in the total lipids, inhibits increase in the lipid peroxidation and decrease in the antioxidant activity in the blood, and improves the ECG characteristics. These data suggest that glycyrram is a promising agent for the treatment of cardiac disorders accompanied by inflammatory and necrotic changes in myocardium, including myocarditis and myocardial infarction.
authors: Laboratory of Pathophysiology and Experimental Pharmacotherapy, Ministry of Public Health of the Republic of Uzbekistan, Tashkent, Uzbekistan.
authors: N U
authors: NU
authors: Zakirov
authors: M I
authors: MI
authors: Aĭzikov
authors: A G
authors: AG
authors: Kurmukov
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D006003:Glycogen / Q000378:metabolism; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D007545:Isoproterenol; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats
chemical_list: D008055:Lipids; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D007545:Isoproterenol; D006034:Glycyrrhetinic Acid