Enhanced proliferation and directed migration of oligodendroglial progenitors co-grafted with growth factor-secreting cells.
Transplantation repair of demyelinating lesions is restricted because relatively few cells can be introduced at only a limited number of sites. Repair could be enhanced by stimulating division of transplanted cells and by directing migration to multiple or distant lesions. This article demonstrates that transplanted oligodendroglial progenitors proliferate more when co-grafted with growth factor-secreting cells, yet retain the capacity to form myelin. Transplanted glial cells also migrate preferentially toward the growth factor-secreting cells when the two are implanted at separate sites. This opens avenues to examine growth factor actions on glia in vivo and improves the prospects for human remyelination therapies.
Milward
E A
EA
School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA.
Zhang
S C
SC
Zhao
M
M
Lundberg
C
C
Ge
B
B
Goetz
B D
BD
Duncan
I D
ID
D000818:Animals; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D009186:Myelin Sheath / Q000473:pathology / Q000502:physiology; D009368:Neoplasm Transplantation; D009414:Nerve Growth Factors / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology; D009447:Neuroblastoma; D009836:Oligodendroglia / Q000166:cytology* / Q000637:transplantation*; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar; D013118:Spinal Cord Diseases / Q000473:pathology / Q000628:therapy; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000378:metabolism / Q000637:transplantation
D009414:Nerve Growth Factors