Stability of ribosilo-6-methylmercaptopurine in aqueous solutions.
The kinetics of hydrolysis of ribosilo-6-methylmercaptopurine was studied in aqueous solution at 353 K over a pH range of 0.45-12.13. The decomposition was followed by HPLC method. The reaction of ribosilo-6-methylmercaptopurine hydrolysis includes: the reaction catalysed by hydrogen ions, that catalysed by hydroxide ions and spontaneous hydrolysis under the effect of water.
Jelińska
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Karol Marcinkowski University of Medical Sciences, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006868:Hydrolysis; D007202:Indicators and Reagents; D007700:Kinetics; D008778:Methylthioinosine; D012996:Solutions
D007202:Indicators and Reagents; D012996:Solutions; D008778:Methylthioinosine