title: Orbital osteoclastoma of apparent extraskeletal origin in a pagetic patient: a case report.
abstract: A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparent either operatively, microscopically, or on preoperative computed tomographic scans. The neoplasm has not recurred in a 3-year follow-up. In addition to the fact that osteoclastoma complicating PBD is rare, the extraskeletal origin of the tumor is a matter of interest and can be tentatively explained by an unusually powerful systemic stimulus acting on circulating osteoclast precursors. HUM PATHOL 31:1527-1531.
authors.affiliation: Dipartimento di Medicina Sperimentale e Patologia, Università degli Studi La Sapienza, Roma, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Pecorella
authors.forename: A
authors.initials: A
authors.lastname: Ciardi
authors.forename: G
authors.initials: G
authors.lastname: Amadeo
authors.forename: A
authors.initials: A
authors.lastname: Baiocchini
authors.forename: A
authors.initials: A
authors.lastname: Marasco
authors.forename: U
authors.initials: U
authors.lastname: Di Tondo
mesh_terms: D005260:Female; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D010001:Osteitis Deformans / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed