The subventricular zone: source of neuronal precursors for brain repair.
The subventricular zone (SVZ) is a major germinal zone which persists in the adult brain. The SVZ contains cells that self renew and continuously produce new neurons and glia. In this chapter we discuss the development, architecture and function of the adult SVZ, as well as the fate of SVZ cells after transplantation. We focus on identification of neural stem cells, factors which regulate neurogenesis and mechanisms for neuronal migration through the adult brain. Detailed understanding of these processes is necessary to utilize the SVZ as a source of neuronal and glial precursors for genetic manipulation, transplantation or brain self repair.
Alvarez-Buylla
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Rockefeller University, 1230 York Avenue 210, New York, NY 10021, USA. alvarez@rockvax.rockefeller.edu
Herrera
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Wichterle
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D000367:Age Factors; D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D016548:Prosencephalon / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology / Q000502:physiology