Role of alpha1-antitrypsin and detoxification functions of the liver in the pathogenesis of endotoxin-induced fever.
CCl4-induced toxic damage to the liver in rats and rabbits is accompanied by inhibition of detoxifying functions of the liver and a decrease in plasma alpha1-antitrypsin content and core body temperature. Injection of pyrogenal stimulated detoxifying functions of the liver, elevated alpha1-antitrypsin content in the blood, and increased body temperature. Intravenous injection of alpha1-antitrypsin caused hyperthermia. No pyrogenal-induced hyperthermia was observed in animals with CC4-induced damage to the liver. These data indicate that functional activity of the liver and blood content of alpha1-antitrypsin play an important role in the mechanisms of thermoregulatory reactions to endotoxin.
Vismont
F I
FI
Department of Pathophysiology, Minsk State Medical Institute.
Shust
O G
OG
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity; D004731:Endotoxins / Q000633:toxicity*; D005260:Female; D005334:Fever / Q000139:chemically induced*; D008099:Liver / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D011817:Rabbits; D051381:Rats; D000515:alpha 1-Antitrypsin / Q000502:physiology*
D004731:Endotoxins; D000515:alpha 1-Antitrypsin; D002251:Carbon Tetrachloride