Pluronic F68 block polymer, a very potent suppressor of carcinogenesis in the colon of rats and mice.
Polyethylene-glycol (PEG) is a strong inhibitor of colon cancer in rats, and the most potent suppressor of aberrant crypt foci. 9 PEG-like block copolymers were tested in rodents, after an azoxymethane injection. Dietary pluronic F68 led to a 98.6% reduction in the number of aberrant crypt foci in a first rat study (P< 0.0001). Next 3 studies confirmed this pluronic efficacy in rats and mice. This non-toxic laxative seems roughly 5 times more potent than PEG for chemoprevention.
Parnaud
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G
Sécurité des Aliments, INRA, Ecole Nationale Vétérinaire de Toulouse, 23 ch. des Capelles, Toulouse, 31076, France.
Taché
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S
Peiffer
G
G
Corpet
D E
DE
D000818:Animals; D003106:Colon / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000517:prevention & control*; D004354:Drug Screening Assays, Antitumor; D005079:Excipients / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D020442:Poloxamer / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011230:Precancerous Conditions / Q000517:prevention & control*; D051381:Rats; D011916:Rats, Inbred F344
D005079:Excipients; D020442:Poloxamer; D011092:Polyethylene Glycols