Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes.
In the search for new marker genes suitable to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture, we have identified and characterized a novel gene called chondrocyte expressed protein-68 (CEP-68), harbouring an N-terminal leader peptide and an epidermal growth factor-like calcium-binding domain. CEP-68 defines a new family of proteins and complements collagen type II as a new marker for stem-cell-based chondrogenic tissue engineering.
Steck
E
E
Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.
Benz
K
K
Lorenz
H
H
Loew
M
M
Gress
T
T
Richter
W
W
D000595:Amino Acid Sequence; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D002478:Cells, Cultured; D019902:Chondrocytes / Q000378:metabolism*; D018076:DNA, Complementary / Q000032:analysis; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D010006:Osteoblasts / Q000378:metabolism; D010641:Phenotype; D020133:Reverse Transcriptase Polymerase Chain Reaction
C422245:CRTAC1 protein, human; D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D005819:Genetic Markers