Gastric emptying in diabetic gastroparetic dogs: ffects of SK-951,a novel prokinetic agent.
We examined whether delayed gastric emptying could be produced by diabetes in dogs. Diabetes was produced by a single injection of streptozotocin (30 mg/kg i.v.), and diabetic hyperglycemia was observed from 2 to 15 months after injection. The plasma acetaminophen concentration, which is an indirect indicator of the gastric emptying rate, was delayed in 2 of 5 diabetic dogs from 15 months after the induction of diabetes. The effects of SK-951, a benzofuran derivative, on delayed gastric emptying were also examined in diabetic gastroparetic dogs in comparison with those of cisapride. SK-951 (1 mg/kg i.v.) significantly enhanced delayed gastric emptying in diabetic dogs, but cisapride (1 mg/kg i.v.) had no effect. In addition, SK-951 increased the plasma glucose levels in a manner correlated with its effect on gastric emptying. The present study suggested that SK-951 may be useful in the treatment of diabetic gastroparesis.
Takeda
M
M
Pharmaceutical Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd., Mie, Japan. m_takeda@mb4.skk-net.com
Mizutani
Y
Y
Yamano
M
M
Tsukamoto
K
K
Suzuki
T
T
D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D020117:Cisapride / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D004285:Dogs; D005746:Gastric Emptying / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D018589:Gastroparesis / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D013997:Time Factors
D001572:Benzofurans; D001786:Blood Glucose; D019086:Bridged Bicyclo Compounds, Heterocyclic; D005765:Gastrointestinal Agents; C113458:SK 951; D000082:Acetaminophen; D020117:Cisapride