title: The peri-implant breast capsule: an immunophenotypic study of capsules taken at explantation surgery.
abstract: Silicone-based breast implants continue to be the focus of many studies attempting to correlate implant failure to clinical and pathological factors. Routine pathology of peri-implant capsule is extensively described in the literature. The actual significance of the cellular events remains unconfirmed, particularly with reference to clinical outcome. This study reviews our experience with explanted capsules. The study makes specific reference to the immunohistochemistry of the cells participating in the capsule and the significance of the immunophenotypic characterization of these cells to clinical outcome. The use of a wide selection of immunomarkers for T and B lymphocytes and histiocytes provided no supporting evidence for local cell participation in the capsule, which may indicate the presence of an immunological reaction present in the capsule at the time of explantation. One was only able to confirm the presence of a low grade inflammatory process and progression to fibrosis and calcification over time. Statistical correlation was obtained only between Baker grade of capsular contracture and CD3/CD68 immunomarker positivity. CD45RO did show correlation with pain. No correlation was demonstrated with calcification. The results obtained in this study highlighted the need for further investigations into the mechanism of histiocyte and fibrocyte recruitment and activation in the capsule, a possible source of pain and contracture, which is a serious long-term clinical finding leading to the necessity for explantation.
authors.affiliation: Laboratory of Bone and Joint Pathology, Department of Anatomic Pathology & Cytology, Wellesley Central Site, St. Michael's Hospital, University of Toronto, Toronto, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Kamel
authors.forename: K
authors.initials: K
authors.lastname: Protzner
authors.forename: V
authors.initials: V
authors.lastname: Fornasier
authors.forename: W
authors.initials: W
authors.lastname: Peters
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Ibanez
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018771:Arthralgia / Q000453:epidemiology; D001168:Arthritis / Q000453:epidemiology; D001940:Breast / Q000276:immunology* / Q000473:pathology; D018427:Breast Implants / Q000009:adverse effects*; D002114:Calcinosis / Q000209:etiology; D019544:Equipment Failure Analysis; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005356:Fibromyalgia / Q000453:epidemiology; D005355:Fibrosis; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D007249:Inflammation; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D011184:Postoperative Period; D015995:Prevalence; D011475:Prosthesis Failure; D020034:Silicone Gels / Q000009:adverse effects*; D016037:Single-Blind Method; D014945:Wound Healing / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D011093:Polyethylene Terephthalates; D020034:Silicone Gels