[Evaluation of various antagonists of CGRP, a neuromediator implicated in the inflammatory mechanisms of nasal mucosa].
BACKGROUND
This article presents a review of the literature addressing the role of different neuropeptides involved in neurogenic inflammation at the level of the nasal mucosa.


CONCLUSIONS
Calcitonin gene-related peptide (CGRP) is a vasodilator peptide located in sensory C fibres. It plays an important role during neurogenic inflammation by controlling both tonicity and permeability of different vascular beds. Its release can be produced by capsaicin, bradykinin (BK) or histamine. In turn, CGRP appears to play an important role in modulating histamine-induced vascular responses. Different CGRP analogues are used to investigate the mechanisms of neurogenic inflammation. Some of them antagonise exogenous substances such as CGRP, capsaicin or bradykinin, attenuating the vasodilatation induced both in intensity and duration. They can contribute to the study of CGRP and its physiological involvement in neurogenic inflammation. Moreover, they may have therapeutic applications in the treatment of patients with nasal hyperreactivity.
Malis
D D
DD
Laboratoire de rhinologie expérimentale, Clinique d'oto-rhino-laryngologie, Hôpitaux Universitaires de Genève.
Lacroix
J S
JS
D001920:Bradykinin / Q000494:pharmacology / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000502:physiology*; D002211:Capsaicin / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D009297:Nasal Mucosa / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*
D006632:Histamine; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin; D001920:Bradykinin