title: [Ocular toxocariasis. Value of local immunodiagnosis].
abstract: Toxocara canis is a nematode that may be involved in human ocular toxocariasis. Specific immunotesting is of importance but may be negative as toxocara antigens may localize exclusively in vitreous humor. We report here the case of one patient with optic disc toxocariasis granuloma negative for toxocara canis immunodiagnostic on serum. Clinical diagnosis was confirmed by toxocara canis specific enzyme-linked immunosorbent assay (ELISA) on aqueous humor showing elevated titers of antibodies. Systemic steroids associated to specific treatment of toxocariasis were initiated. Follow-up displayed regression of uveitis but development of vitreous bands leading to posterior retinal detachment. Toxocara posterior granuloma is of poor visual prognosis. Moreover, diagnosis may be of late setting, as clinical features are often unrecognized and specific immunodiagnostic on serum negative. Specific immunotesting on aqueous humor is of particular importance to rule out severe clinical differential diagnosis such as retinoblastoma in children. Ultrasound biomicroscopy (UBM) seems to be specific and sensitive in patients with a presumed diagnosis of peripheral toxocariasis. Granuloma surgery appears to yield good clinical results and allows histological confirmation of the diagnosis.
authors.affiliation: Service d'ophtalmologie, CMC Gui de Chauliac, 34295 Montpellier, Cedex 5. cfsb@mnet.fr
authors.forename: C
authors.initials: C
authors.lastname: Schneider
authors.forename: B
authors.initials: B
authors.lastname: Arnaud
authors.forename: C F
authors.initials: CF
authors.lastname: Schmitt-Bernard
mesh_terms: D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis*; D001082:Aqueous Humor / Q000276:immunology*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D015822:Eye Infections, Parasitic / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006099:Granuloma / Q000469:parasitology / Q000601:surgery; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D017166:Toxocara canis / Q000276:immunology; D014120:Toxocariasis / Q000175:diagnosis* / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D011241:Prednisone