Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder.
The insertion/deletion polymorphism of the gene of angiotensin-converting enzyme (ACE) was investigated in a case-control study including 169 patients with suffering from either bipolar disorder type I or unipolar recurrent major depression (DSM-IV) and 169 healthy controls. No significant association was found with bipolar disorder type I or unipolar recurrent depression and the polymorphism of the ACE gene. A previously reported genetic association (Arinami et al., 1996) was not confirmed by the present study.
Pauls
J
J
Department of Psychiatry, University of Göttingen, Federal Republic of Germany. jpauls@gwdg.de
Bandelow
B
B
Rüther
E
E
Kornhuber
J
J
D000328:Adult; D000368:Aged; D000483:Alleles; D004251:DNA Transposable Elements; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A