title: [Mechanism of local anesthesia: long-range orientation effects].
abstract: The orientation interaction of a molecule of a local anesthetic with a biomembrane and cell-like liquid was studied, based on the model of adsorption of the anesthetic from a cell-like solution on the surface of a biomembrane for compounds of the trimecaine series. A statistically significant correlation equation was obtained, which relates the minimum blocking concentration to the projection of the dipole moment of the anesthetic on the plane X(1)0X2 of the principal axes of inertia. A model is prosed according to which the "anesthetic-biomembrane" interaction is most effective the molecule of the anesthetic rotates around the axis of the maximum moment of inertia.
authors.affiliation: Lipetsk State Pedagogical Institute, ul. Lenina 42, Lipetsk, 398020 Russia.
authors.forename: G A
authors.initials: GA
authors.lastname: Isaev
authors.forename: A V
authors.initials: AV
authors.lastname: Dmitriev
authors.forename: P P
authors.initials: PP
authors.lastname: Isaev
mesh_terms: D000779:Anesthetics, Local / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects; D008563:Membrane Lipids / Q000737:chemistry; D014288:Trimecaine / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000779:Anesthetics, Local; D008563:Membrane Lipids; D014288:Trimecaine