Effect of NSAID administration on creatinine clearance in healthy dogs undergoing anaesthesia and surgery.
Thirty healthy male dogs were randomly assigned to receive carprofen (4 mg/kg intravenously), ketoprofen (2 mg/kg intravenously) or saline (0.2 ml/kg intravenously) at induction of anaesthesia for castration surgery. A routine castration was undertaken and a buccal mucosal bleeding time was assessed at the completion of surgery. Twenty-four hours after surgery a 24-hour endogenous creatinine clearance study was undertaken. Buccal mucosal bleeding time was not significantly different between the three groups. Creatinine clearance was significantly lower (P < or = 0.01) in the two groups of dogs that received a non-steroidal anti-inflammatory drug compared with that in the dogs that received sterile saline. There was no significant difference between the carprofen and ketoprofen groups with respect to creatinine clearance.
Forsyth
S F
SF
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
Guilford
W G
WG
Pfeiffer
D U
DU
D000758:Anesthesia / Q000662:veterinary; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001760:Bleeding Time / Q000662:veterinary; D002227:Carbazoles / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood / Q000652:urine*; D004285:Dogs / Q000502:physiology* / Q000601:surgery; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000662:veterinary*; D007660:Ketoprofen / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects*; D008297:Male; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D007660:Ketoprofen; D003404:Creatinine; C007005:carprofen