The Role of presenilins in gamma-secretase activity.
Wolfe
M S
MS
Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. wolfe@cnd.bwh.harvard.edu
Haass
C
C
D000544:Alzheimer Disease / Q000209:etiology*; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011956:Receptors, Cell Surface / Q000378:metabolism; D051880:Receptors, Notch
D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human