title: Diterpene from Baccharis trimera with a relaxant effect on rat vascular smooth muscle.
abstract: A bioassay monitored fractionation of a chloroform extract from the aerial parts of Baccharis trimera yielded a mixture that blocked the Ca2+-induced contractions of KCl- depolarized rat portal vein preparations. Pharmacological tests of two pure compounds isolated from the mixture revealed the dilactonic clerodane diterpene as the active compound.
authors.affiliation: Universidade Federal de São Paulo, Escola Paulista de Medicina, Department of Pharmacology, SP, Brazil. luce.farm@infar.epm.br
authors.forename: L M
authors.initials: LM
authors.lastname: Torres
authors.forename: M T
authors.initials: MT
authors.lastname: Gamberini
authors.forename: N F
authors.initials: NF
authors.lastname: Roque
authors.forename: M T
authors.initials: MT
authors.lastname: Lima-Landman
authors.forename: C
authors.initials: C
authors.lastname: Souccar
authors.forename: A J
authors.initials: AJ
authors.lastname: Lapa
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004224:Diterpenes