A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents.
A convenient synthesis of nonsymmetrical bivalent inhibitors of the serotonin transporter is described. The synthesis utilizes polymer-supported reagents that allow for rapid access to novel bivalent ligands without the need for isolation or purification of synthetic intermediates.
Tamiz
A P
AP
Department of Neurology, Georgetown University Medical Center, Washington, DC 20007-2197, USA.
Conti
P
P
Zhang
M
M
Johnson
K M
KM
Kozikowski
A P
AP
D000818:Animals; D003432:Cross-Linking Reagents; D003959:Diamines / Q000138:chemical synthesis / Q000378:metabolism; D008024:Ligands; D011108:Polymers; D011485:Protein Binding; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000378:metabolism
D003432:Cross-Linking Reagents; D003959:Diamines; D008024:Ligands; D011108:Polymers; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D017367:Selective Serotonin Reuptake Inhibitors