title: Frequency of protein S deficiency in general Japanese population.
abstract: We measured protein S (PS) activity in a large group of Japanese subjects to study the frequency of PS deficiency. The study group comprised 213 men, ages 18-58 years, and 179 women, ages 18-60 years. PS activity in the total 392 subjects was 58-135% (mean +/- 2 SD), 65-135% in the men and 54-120% in the women. The men showed significantly higher levels of PS activity than the women (p<0.001). We identified 8 subjects (4 men and 4 women) in whom PS activity was lower than the mean-2SD for men and women, respectively. Moreover, we examined the classifications of PS deficiency. The frequency of PS deficiency in this study was 2.04% (Type I: 0.51%, Type II: 1.02%, Type III: 0.51%). Based on our findings, it would appear that the frequency of Type II PS deficiency in the Japanese population is approximately 1%. The screening of PS decrease should be judged by activity.
authors.affiliation: Central Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: E
authors.initials: E
authors.lastname: Suehisa
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.forename: A
authors.initials: A
authors.lastname: Okada
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017293:Protein S / Q000378:metabolism*; D018455:Protein S Deficiency / Q000145:classification / Q000453:epidemiology* / Q000378:metabolism
chemical_list: D017293:Protein S