Complexometric determination of diphosphonic acid derivatives. Part II.
The purpose of the study is to develop complexometric method determination of diphosphonic acid derivatives in pharmaceutical preparations used in the treatment of osteoporosis, vis., disodium etidronate, disodium tiludronate, disodium pamidronate and sodium alendronate. The visual end-point titration method involving either as complexing reagent Th(DCTA) or Th(EDTA) in the presence of xylenol orange or methyl thymol blue, uses the ability of these compounds to form complexes.
Podolska
M
M
Drug Institute, 30/34 Chełmska Str., Warsaw, Poland.
Białecka
W
W
Kwiatkowska-Puchniarz
B
B
D007202:Indicators and Reagents; D063065:Organophosphonates / Q000032:analysis*; D012996:Solutions
D007202:Indicators and Reagents; D063065:Organophosphonates; D012996:Solutions