title: Microbial and chemical conversion of antibiotic K41. II. Preparation of K41-DA1, -DA2 and -DA3 deamicetosyl derivatives of antibiotic K41.
abstract: Antibiotic derivative K41-DA1, -DA2 and -DA3 (2 approximately 4), deamicetosyl derivatives of antibiotic K41 (1), were prepared by acidic degradation of K41 and following hydrogenation reaction. K41-DA2 (3) showed comparable antimicrobial activities to K41 in vitro but not in vivo.
authors.affiliation: Department of Pharmaceutical Sciences, Kyoritsu College of Pharmacy, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hoshi
authors.forename: T
authors.initials: T
authors.lastname: Endo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D016786:Eimeria tenella / Q000187:drug effects; D004987:Ethers / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D006601:Hexoses / Q000737:chemistry; D006865:Hydrogenation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests / Q000379:methods; D021261:Parasitic Sensitivity Tests; D013302:Streptomyces / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D004987:Ethers; D006601:Hexoses; C006487:amicetose; C012106:K 41