title: Effect of variations in operational definitions on performance estimates for screening mammography.
abstract: OBJECTIVE
  The Mammography Quality Standards Act requires practices to measure limited aspects of their performance. The authors conducted this study to calculate the differences in measurements of sensitivity and specificity due only to differences in the definitions used in the analysis. This included definitions for case inclusion.
  
  
  METHODS
  Data from the New Mexico Mammography Project for January 1991 to December 1995 on 136,540 women who underwent screening mammography were analyzed. A starting definition was created for each performance measure. The components of the definition were varied, and estimates of sensitivity and specificity for the different definitions were calculated.
  
  
  RESULTS
  Sensitivity was lower and specificity was higher when assessed on the basis of the results of all imaging performed in the screening work-up rather than on the initial screening examination alone. Sensitivity was higher and specificity was lower in women who did not undergo rather than in women who did recently undergo a previous examination. When the definition of a positive examination included cases that were recommended for short-term follow-up, the work-up sensitivity was slightly higher and the work-up specificity was considerably lower. Longer follow-up times for determining the diagnosis of cancer were associated with decreasing sensitivity, particularly when the follow-up period extended beyond 12 months.
  
  
  CONCLUSIONS
  Variations in the operational definitions for measures of mammographic performance affect these estimates. To facilitate valid comparisons, reports need to be explicit regarding the definitions and methods used.
authors.affiliation: Department of Radiology, University of New Mexico Health Sciences Center, Albuquerque 87131, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Rosenberg
authors.forename: B C
authors.initials: BC
authors.lastname: Yankaskas
authors.forename: W C
authors.initials: WC
authors.lastname: Hunt
authors.forename: R
authors.initials: R
authors.lastname: Ballard-Barbash
authors.forename: N
authors.initials: N
authors.lastname: Urban
authors.forename: V L
authors.initials: VL
authors.lastname: Ernster
authors.forename: K
authors.initials: K
authors.lastname: Kerlikowske
authors.forename: B
authors.initials: B
authors.lastname: Geller
authors.forename: P A
authors.initials: PA
authors.lastname: Carney
authors.forename: S
authors.initials: S
authors.lastname: Taplin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008327:Mammography / Q000592:standards*; D008403:Mass Screening; D008875:Middle Aged; D012680:Sensitivity and Specificity