title: DNA vaccination with the human immunodeficiency virus type 1 SF162DeltaV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8(+) T-cell-depleted rhesus macaques.
abstract: DNA immunization of macaques with the SF162DeltaV2 envelope elicited lymphoproliferative responses and potent neutralizing antibodies. The animals were depleted of their CD8(+) T lymphocytes and then challenged intravenously with SHIV162P4. Compared to unvaccinated animals, the vaccinated macaques had lower peak viremia levels, rapidly cleared plasma virus, and showed delayed seroconversion.
authors.affiliation: Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10021-6399, USA.
authors.forename: S
authors.initials: S
authors.lastname: Cherpelis
authors.forename: I
authors.initials: I
authors.lastname: Shrivastava
authors.forename: A
authors.initials: A
authors.lastname: Gettie
authors.forename: X
authors.initials: X
authors.lastname: Jin
authors.forename: D D
authors.initials: DD
authors.lastname: Ho
authors.forename: S W
authors.initials: SW
authors.lastname: Barnett
authors.forename: L
authors.initials: L
authors.lastname: Stamatatos
mesh_terms: D016915:AIDS Vaccines / Q000276:immunology*; D000163:Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1 / Q000276:immunology*; D008212:Lymphocyte Depletion; D008253:Macaca mulatta; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D015483:HIV Antibodies; D019444:Vaccines, DNA; D014759:Viral Envelope Proteins