title: [Relationship between chronic viral hepatitis and hepatocellular  carcinoma].
abstract: Recent years have seen a correlation between the rise in morbidity and lethality from chronic viral hepatitis and that of hepatocellular carcinoma. Present-day methods of hepatotropic viruses (HBV and HCV) identification point to a growing role of chronic viral hepatitis in etiology of cirrhosis which gives rise to hepatocellular cancers. A study of 49 cases based on sectional material established hepatocellular carcinoma development in smoldering chronic viral hepatitis caused by B or C virus or their combination. An immunohistochemical investigation (29) identified differences in hepatitis B and C virus antigen expression in tumor and adjacent hepatic tissue.
authors.affiliation: State University, S.P. Botkin Municipal Infectious Hospital No. 30, St. Petersburg.
authors.forename: V E
authors.initials: VE
authors.lastname: Karev
authors.forename: V A
authors.initials: VA
authors.lastname: Tsinzerling
authors.forename: D V
authors.initials: DV
authors.lastname: Komarova
authors.forename: A A
authors.initials: AA
authors.lastname: Iakovlev
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000821:virology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000032:analysis; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology / Q000821:virology*
chemical_list: D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies