No sympathetic nerve sprouting in rat trigeminal ganglion following painful and non-painful infraorbital nerve neuropathy.
Following sciatic nerve injury sympathetic invasion and basket formation is seen in dorsal root ganglia. We examined whether this phenomenon occurs in trigeminal ganglion (TG) following axotomy (IOAx) or chronic constriction injury to the infraorbital nerve (IOCCI). The IOCCI rats developed hyperresponsiveness to pinprick stimulation consistent with this model and the IOAx rats remained hyporesponsive for most of the study period. Immunocytochemistry employing antibodies to tyrosine hydroxylase showed no sympathetic invasion or basket formation 2 and 7 weeks post surgery. This study confirms previous work that found no sympathetic invasion of TG following injury, and shows that this finding is unaffected by the presence or absence of nerve injury induced hyperresponsiveness.
Benoliel
R
R
Department of Oral Diagnosis, Oral Medicine and Oral Radiology, The Hebrew University, Hadassah School of Dental Medicine, Jerusalem, Israel. benoliel@cc.huji.ac.il
Eliav
E
E
Tal
M
M
D000818:Animals; D019771:Axotomy; D003250:Constriction; D005156:Facial Neuralgia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D006930:Hyperalgesia / Q000209:etiology / Q000503:physiopathology; D007150:Immunohistochemistry; D008297:Male; D008442:Maxillary Nerve / Q000503:physiopathology*; D009915:Orbit / Q000294:innervation* / Q000503:physiopathology; D010147:Pain Measurement; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology; D017783:Superior Cervical Ganglion / Q000473:pathology; D013564:Sympathetic Nervous System / Q000473:pathology / Q000503:physiopathology*; D012668:Trigeminal Ganglion / Q000473:pathology*; D014276:Trigeminal Nerve / Q000473:pathology / Q000502:physiology