title: Complete bilateral horizontal gaze paralysis disclosing multiple sclerosis.
abstract: Two women presented with bilateral internuclear ophthalmoplegia evolving in a few days to complete bilateral horizontal gaze paralysis. Convergence and vertical eye movements were normal. Cerebral MRI showed a few small white matter lesions in the lateral ventricle regions, and, at the brainstem level, a single, small, bilateral lesion affecting the posterior part of the medial pontine tegmentum and responsible for the clinical syndrome. The condition gradually improved in both patients, following a similar progression as at the onset: improvement first involved the adduction movements in both eyes, whereas bilateral abduction paresis still persisted for a few weeks, before complete recovery of eye movements. Bilateral damage to the medial longitudinal fasciculus and subsequent lateral extent of damage to the region of the two abducens emerging fibres may explain the clinical findings. In both cases, the cause was probably multiple sclerosis.
authors.affiliation: Department of Ophthalmology, Hôpital de la Pitié-Salpêtrière, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Milea
authors.forename: M
authors.initials: M
authors.lastname: Napolitano
authors.forename: H
authors.initials: H
authors.lastname: Dechy
authors.forename: P
authors.initials: P
authors.lastname: Le Hoang
authors.forename: J Y
authors.initials: JY
authors.lastname: Delattre
authors.forename: C
authors.initials: C
authors.lastname: Pierrot-Deseilligny
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology*; D015835:Ocular Motility Disorders / Q000150:complications / Q000473:pathology*