title: Effects of intestinal transplantation on postprandial motility and regulation of intestinal transit.
abstract: BACKGROUND
  The effects of intestinal transplantation on gut motility have not been completely defined. In this study we examine the effects of ileal transplantation on ileal smooth muscle contractility, together with gastroduodenal emptying, intestinal flow, and transit rates in a canine model of short-gut syndrome.
  
  
  METHODS
  Animals (n = 22) were instrumented with strain gauge transducers, collection cannulae, and infusion catheters to assess motility, intestinal flow and transit rates, and gastroduodenal emptying. Ten animals served to define normal parameters. Six animals underwent a 70% resection of the proximal small intestine to serve as short-gut controls. Six animals underwent removal of a 100-cm segment of the ileum, with cold storage, and autotransplantation the following day combined with a 70% resection of proximal bowel.
  
  
  RESULTS
  Transplant animals exhibited delayed gastroduodenal emptying, reduced intestinal flow rates, and postprandial phasic contractions that were similar to short-gut controls. However, transplant animals experienced rapid intestinal transit compared with short-gut controls (4.8 +/- 0.4 cm/min vs 2.0 +/- 0.3 cm/min; mean +/- SEM; P <.05).
  
  
  CONCLUSIONS
  The transplanted intestine, even with 18 hours of cold storage, exhibits a relatively normal postprandial motor response. However, adaptive responses of the transplanted intestine, such as regulation of intestine transit, may be impaired by neuromuscular injury associated with denervation or ischemia.
authors.affiliation: Division of Transplantation and General Surgery, The Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Johnson
authors.forename: S K
authors.initials: SK
authors.lastname: Sarna
authors.forename: Y R
authors.initials: YR
authors.lastname: Zhu
authors.forename: E
authors.initials: E
authors.lastname: Buchmann
authors.forename: L
authors.initials: L
authors.lastname: Bonham
authors.forename: G L
authors.initials: GL
authors.lastname: Telford
authors.forename: A M
authors.initials: AM
authors.lastname: Roza
authors.forename: M B
authors.initials: MB
authors.lastname: Adams
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004435:Eating; D005215:Fasting; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007082:Ileum / Q000503:physiopathology / Q000637:transplantation*; D008297:Male; D009119:Muscle Contraction; D012778:Short Bowel Syndrome / Q000503:physiopathology / Q000601:surgery*; D014182:Transplantation, Autologous