title: Biliary stricture secondary to donor B-cell lymphoma after orthotopic liver transplantation.
abstract: Biliary complications after orthotopic liver transplantation (OLT) lead to considerable morbidity and occasional mortality after surgery. Bile duct strictures secondary to localized lymphoproliferative disorder of the porta hepatis is rare, with only 12 cases reported in the English literature. Posttransplant lymphoproliferative disorder develops in up to 9% of liver allograft recipients. We describe 2 adult patients who developed Epstein-Barr virus-associated localized B-cell lymphoma of donor-tissue origin confined to the porta hepatis 3 and 5 months after OLT. Both patients were administered cyclosporine (CyA) and prednisone as primary immunosuppression. One patient was administered basiliximab as induction therapy. Neither patient had CyA trough levels greater than 250 ng/mL. Both patients were treated with a hepatojejunostomy, 75% reduction in immunosuppression therapy, and acyclovir. One patient had complete involution of the tumor, and the second patient had an 80% reduction of the tumor at the 2-year follow-up visit. This report illustrates the need to consider localized lymphoma post-OLT as a cause of obstructive jaundice even within the first 6 months after surgery. Aggressive reduction of immunosuppression in conjunction with acyclovir remains a highly effective therapy.
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, NC, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Baron
authors.forename: M A
authors.initials: MA
authors.lastname: Heneghan
authors.forename: P V
authors.initials: PV
authors.lastname: Suhocki
authors.forename: J D
authors.initials: JD
authors.lastname: Nuckols
authors.forename: J E
authors.initials: JE
authors.lastname: Tuttle-Newhall
authors.forename: D N
authors.initials: DN
authors.lastname: Howell
authors.forename: P A
authors.initials: PA
authors.lastname: Clavien
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D002779:Cholestasis / Q000209:etiology* / Q000628:therapy; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D014019:Tissue Donors
chemical_list: D007166:Immunosuppressive Agents; D000212:Acyclovir