title: Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
abstract: A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
authors.affiliation: Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uk
authors.forename: N J
authors.initials: NJ
authors.lastname: Lawrence
authors.forename: D
authors.initials: D
authors.lastname: Rennison
authors.forename: M
authors.initials: M
authors.lastname: Woo
authors.forename: A T
authors.initials: AT
authors.lastname: McGown
authors.forename: J A
authors.initials: JA
authors.lastname: Hadfield
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003078:Colchicine / Q000037:antagonists & inhibitors / Q000378:metabolism; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D011485:Protein Binding / Q000187:drug effects; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014404:Tubulin / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D004987:Ethers; D013267:Stilbenes; D014404:Tubulin; C058728:fosbretabulin; D003078:Colchicine