title: [Ocular hypotensive effect of pilocarpine in latanoprost treated eyes; a pilot study].
abstract: OBJECTIVE
  To study the ocular hypotensive effect of pilocarpine in latanoprost treated eyes.
  
  
  METHODS
  We measured the IOP in both eyes of 25 patients, before and after instillation of pilocarpine 2% in one eye, and placebo in the other. This is a prospective, double blind, placebo-controlled study.
  
  
  RESULTS
  We found that the mean change in IOP of the study eyes was +0.4 on average (range of change from -3 to +5 mmHg), compared with the control, placebo treated eyes (p=0.5).
  
  
  CONCLUSIONS
  The acute administration of pilocarpine in Latanoprost treated eyes seems to have a paradoxical effect on IOP, as the IOP may increase or decrease.
authors.affiliation: Servicio de Oftalmología, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
authors.lastname: Teus Guezala MA
authors.lastname: Arranz Márquez E
authors.lastname: Morales Bertrand J
authors.lastname: Marcos De La Huerga A
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000494:pharmacology*; D010862:Pilocarpine / Q000494:pharmacology*; D010865:Pilot Projects; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
chemical_list: D000959:Antihypertensive Agents; D018721:Muscarinic Agonists; D011461:Prostaglandins F, Synthetic; D010862:Pilocarpine; D000077338:Latanoprost