[Histomorphological study of mice inbred CBA liver under combined chronic influence of low dose gamma radiation and incorporated thorium nitrate].
We studied histomorphology of the CBA line mice liver after 30 and 90 days of the low dose gamma-radiation influence combined with incorporated Th(NO3)4 in doses 0.03; 0.1; 0.3 grams per kilogram of the living mouse weight. Morphophysiological and morphometric changes were shown. The liver mass and index were significant by increased after 30 days influence. The same changes after 90 days influence were not shown. The morphometric parameters (dynamics of double-nucleus and polyploid hepatocytes, nucleoluses numbers) gave evidence of the liver energy disbalance.
Gur'ev
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Institute of Biology, Department of Radioecology, Komi Scientific Center of Ural Division, Russian Academy of Sciences, Syktyvkar, 167610, Russia. guryev@ib.komisc.ru
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D000818:Animals; D002455:Cell Division / Q000528:radiation effects; D002467:Cell Nucleus / Q000473:pathology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects*; D008099:Liver / Q000473:pathology* / Q000528:radiation effects; D008115:Liver Regeneration / Q000528:radiation effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000209:etiology / Q000473:pathology*; D012990:Soil Pollutants, Radioactive / Q000008:administration & dosage* / Q000633:toxicity; D017970:Thorium Compounds / Q000008:administration & dosage* / Q000633:toxicity
D012990:Soil Pollutants, Radioactive; D017970:Thorium Compounds; C036680:thorium nitrate