The use of lepirudin for anticoagulation in patients with heparin-induced thrombocytopenia during major vascular surgery.
The method of anticoagulation in patients undergoing major vascular surgery with a history of heparin-induced thrombocytopenia (HIT) is controversial. We present two cases in which a bolus only technique using recombinant hirudin (Lepirudin or Refludan) was used successfully in patients with HIT scheduled for vascular surgery.
Sun
Y
Y
Department of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas.
Greilich
P E
PE
Wilson
S I
SI
Jackson
M R
MR
Whitten
C W
CW
D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D006493:Heparin / Q000009:adverse effects*; D006629:Hirudins / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011994:Recombinant Proteins / Q000494:pharmacology*; D013921:Thrombocytopenia / Q000139:chemically induced*; D014656:Vascular Surgical Procedures
D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; D006493:Heparin; C083544:lepirudin