title: Effects of mandibular advancement on respiratory resistance.
abstract: Mandibular advancing devices are proposed as nonsurgical treatment for certain patients with an obstructive sleep apnoea syndrome. Since they act by increasing the upper airway calibre, the aim of the present study was to investigate the changes in respiratory resistance (Rrs) resulting from mandibular advancement. Rrs was measured at the nose by the forced oscillation technique (4-32 Hz). Ten normal subjects were studied under three conditions: resting mandibular position, passive mandibular advancement steadied by a wax bite, and voluntary advancement, in random order. Respiratory resistance was extrapolated to 0 Hz (R0) and estimated at 16 Hz (R16) by linear regression analysis of respiratory resistive impedance versus frequency. R0 (mean+/-SEM=3.5+/-0.2 cmH2O x L(-1) x s in the resting position) decreased significantly with passive advancement (2.9+/-0.2 cmH2O x L(-1) x s, p<0.001), but remained unchanged with voluntary mandibular advancement (3.6+/-0.2 cmH2O x L(-1) s). Similar results were obtained for R16. The results of this study demonstrate that the effects of mandibular advancement on upper airway resistance differ, depending on whether advancement is passive or active, and suggest that in order to simulate the actual effects of therapeutic devices, mandibular advancement should be passive.
authors.affiliation: INSERM U 492 et Service de Physiologie, H pital Henri Mondor, AP-HP, et Université Paris XII, Créteil, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Lorino
authors.forename: M
authors.initials: M
authors.lastname: Maza
authors.forename: M P
authors.initials: MP
authors.lastname: d'Ortho
authors.forename: A
authors.initials: A
authors.lastname: Coste
authors.forename: A
authors.initials: A
authors.lastname: Harf
authors.forename: H
authors.initials: H
authors.lastname: Lorino
mesh_terms: D000328:Adult; D000403:Airway Resistance; D018592:Cross-Over Studies; D005260:Female; D006612:High-Frequency Ventilation; D006801:Humans; D008297:Male; D019186:Mandibular Advancement; D008875:Middle Aged; D009296:Nasal Cavity / Q000502:physiology; D009991:Oscillometry / Q000379:methods; D012044:Regression Analysis; D012129:Respiratory Function Tests