title: Antigen processing in the endocytic compartment.
abstract: Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the invariant chain, prepares the class II MHC molecule for capture of those peptides. A clearer picture is emerging of the proteases, protease inhibitors and other factors that together control the environment for class II MHC peptide loading. However, the details of invariant-chain processing and antigen processing may differ depending on the allele of class II and the antigen substrate under consideration.
authors.affiliation: Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK. c.watts@dundee.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Watts
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D004705:Endocytosis / Q000276:immunology*; D011992:Endosomes / Q000276:immunology* / Q000378:metabolism*; D006801:Humans