T-targets: clues to understanding the functions of T-box proteins.
Members of the T-box gene family have been identified in both vertebrates and invertebrates, where they play key roles in the regulation of embryonic development, and particularly in morphogenesis and the assignment of cell fate. T-box proteins act as transcription factors which regulate the expression of downstream effector genes. This review focuses on the identification of T-box target genes and the basis of T-box functional specificity.
Tada
M
M
Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom. m.tada@ucl.ac.uk
Smith
J C
JC
D000818:Animals; D001483:Base Sequence; D005326:Fetal Proteins; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D017434:Protein Structure, Tertiary; D020825:T-Box Domain Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation; D000098908:Brachyury Protein
D005326:Fetal Proteins; D020825:T-Box Domain Proteins; D014157:Transcription Factors; D000098908:Brachyury Protein