Biosynthesis of the methanogenic cofactors.
Our current knowledge of the pathways and genes involved in the biosynthesis of the methanogenic coenzymes methanopterin, coenzyme B, methanofuran, coenzyme F420, and coenzyme M is presented. Proposed reaction mechanisms for several of the novel reactions involved in the pathways are presented.
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Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
D003067:Coenzymes / Q000096:biosynthesis* / Q000378:metabolism; D005663:Furans / Q000378:metabolism*; D019848:Gene Expression Regulation, Archaeal; D015080:Mesna / Q000378:metabolism; D017017:Methanococcus / Q000235:genetics* / Q000378:metabolism; D015394:Molecular Structure; D010769:Phosphothreonine / Q000031:analogs & derivatives* / Q000378:metabolism; D011622:Pterins / Q000378:metabolism*; D012256:Riboflavin / Q000031:analogs & derivatives / Q000096:biosynthesis
D003067:Coenzymes; D005663:Furans; D011622:Pterins; C049349:7-mercaptoheptanoylthreonine phosphate; D010769:Phosphothreonine; C015084:coenzyme F420; C036686:methanopterin; C044289:carbon dioxide reduction factor; D015080:Mesna; D012256:Riboflavin