Antifungal amides from Piper hispidum and Piper tuberculatum.
Piper hispidum and Piper tuberculatum accumulate amides bearing isobutyl, pyrrolidine, dihydropyridone and piperidine moieties. The isolation and characterization of several representatives including two hitherto unreported amides were performed by chromatographic techniques and by analysis of spectroscopic data. The antifungal activity of each amide was determined by direct bioautography against Cladosporium sphaerospermum.
Navickiene
H M
HM
Instituto de Química, Universidade Estadual Paulista, Araraquara-SP, Brazil.
Alécio
A C
AC
Kato
M J
MJ
Bolzani
V D
VD
Young
M C
MC
Cavalheiro
A J
AJ
Furlan
M
M
D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests
D000577:Amides; D000935:Antifungal Agents