[Histopathological evaluation of vitamin E derivatives effects on the healing process of a model of filtration surgery].
OBJECTIVE
To describe the effect of alpha-tocopherol derivatives (acetate and acid succinate) on the histopathological characteristics of the surgical fistulae in an experimental model of filtering surgery.


METHODS
30 pigmented rabbits were randomly divided into 3 study groups. Twenty-four hours before surgery the animals were injected subconjunctivally with 0.5 ml of solution: group I (n=10) 0.75% ethanol in balanced saline solution (BSS), group II (n=10) 100 microgrs alpha-tocopherol acetate (AT) in 0.75% ethanol in BSS, group III (n=10) 100 microgrs alphatocopherol acid succinate (ST) in 0.75% ethanol in BSS. Histological findings were evaluated 30 days after surgery.


RESULTS
The groups treated with alpha-tocopherol derivatives showed a higher percentage of fistular persistence and smaller wound healing areas. There was a subconjunctival cellular infiltrate of mononuclear and eosinophilic cells.


CONCLUSIONS
Histological findings support the clinical use of alpha tocopherol derivatives, AT and ST. to inhibit the wound healing processes associated to filtering surgery failure.
Larrosa Poves JM
Servicio de Oftalmología, Servicio de Anatomía Patológica, Hospital Miguel Servet, Zaragoza, España.
Polo Llorens V
Ramírez Gasca T
Pinilla Lozano I
Pablo Júlvez LE
Cuevas Andrés R
Rojo Aragües A
Honrubia López FM
D000818:Animals; D018463:Filtering Surgery; D011817:Rabbits; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols