title: Polycyclic aromatic compounds as anticancer agents: synthesis and biological evaluation of dibenzofluorene derivatives.
abstract: Highly regioselective electrophilic substitution of dibenzofluorene was achieved and the nitro derivative was transformed to a variety of new anticancer agents.
authors.affiliation: The University of Texas, M. D. Anderson Cancer Center, Department of Molecular Pathology, Houston 77030, USA. banik@mdanderson.org
authors.forename: F F
authors.initials: FF
authors.lastname: Becker
authors.forename: C
authors.initials: C
authors.lastname: Mukhopadhyay
authors.forename: L
authors.initials: L
authors.lastname: Hackfeld
authors.forename: I
authors.initials: I
authors.lastname: Banik
authors.forename: B K
authors.initials: BK
authors.lastname: Banik
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005449:Fluorenes; D011084:Polycyclic Aromatic Hydrocarbons