Multiple molecular forms of glucagon and insulin in the kaluga sturgeon, Huso dauricus.
Five molecular forms of glucagon and two molecular forms of insulin were characterized from the kaluga sturgeon. Substitutions occurred at two to thirteen internal amino acid residues among the five molecular forms of glucagons, indicating that these glucagons were encoded by five distinct genes. The amino acid sequences of two insulins from the kaluga sturgeon were identical to those of paddlefish insulin-II and Russian sturgeon insulin except that kaluga sturgeon insulin-I had an extension of five residues at the B-chain N-terminus. This is the first demonstration that more than two molecular forms of glucagon have been characterized from a single animal species.
Andoh
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Hokkaido National Fisheries Research Institute, 116 Katsurakoi, 085-0802, Kushiro, Japan. andoh@hnf.affrc.go.jp
Nagasawa
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Matsubara
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D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D017124:Conserved Sequence; D019143:Evolution, Molecular; D005399:Fishes; D005934:Glucagon / Q000737:chemistry* / Q000235:genetics*; D007328:Insulin / Q000737:chemistry* / Q000235:genetics*; D008969:Molecular Sequence Data; D010179:Pancreas / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D013997:Time Factors; D014466:Ultraviolet Rays
D007328:Insulin; D005934:Glucagon