Perinatal renal ischemia resulting in hypertensive cardiomyopathy.
Three neonates presented with malignant hypertension during the first week of life; 2 of them had congestive heart failure. Although none had indwelling umbilical artery catheters, unilateral renovascular lesions were diagnosed by nuclear perfusion scans. Angiotensin-converting enzyme inhibitor therapy produced rapid recovery. Hypertension must be included in the differential diagnosis of infants presenting with congestive heart failure and acidosis. Ultrasonography is not sensitive enough to exclude renovascular lesions. We emphasize the importance of early diagnosis and treatment.
Saland
J M
JM
Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, USA.
Mahony
L
L
Baum
M
M
D000138:Acidosis / Q000209:etiology; D001284:Atrophy; D005260:Female; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy / Q000209:etiology*; D007231:Infant, Newborn; D007511:Ischemia / Q000150:complications*; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D011877:Radionuclide Imaging; D014463:Ultrasonography