Expression of 5-HT(1A) receptor mRNA in rat nucleus raphe magnus neurons after peripheral inflammation.
The present study demonstrated that 5-HT(1A) receptor mRNA was expressed with moderate level in the NRM neurons. Most of 5-HT(1A) receptor mRNA positive cells were 5-HT neurons, suggesting the majority of 5-HT(1A) receptor in the NRM might be autoreceptors. Eight hours after carrageenan inflammation, the expression of 5-HT(1A) receptor mRNA in the NRM neurons, especially in the 5-HT neurons, was significantly increased. These results suggest that synthesis of 5-HT(1A) receptors, including 5-HT(1A) autoreceptors, is increased in the NRM during peripheral inflammation.
Zhang
Y
Y
State Key Laboratory of Medical Neurobiology, Department of Neurobiology, Medical Center of Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China.
Gao
X
X
Yang
Z L
ZL
Huang
Y L
YL
Wu
G C
GC
D000818:Animals; D002351:Carrageenan; D005786:Gene Expression Regulation; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D011903:Raphe Nuclei / Q000473:pathology / Q000502:physiology / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000235:genetics*; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin / Q000378:metabolism; D014158:Transcription, Genetic
D012333:RNA, Messenger; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012701:Serotonin; D002351:Carrageenan