title: Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.
authors.affiliation: Gonex, Inc., Colorado State University, ARBL, Ft. Collins, Colorado 80523-1683, USA.
authors.forename: K
authors.initials: K
authors.lastname: Ohmoto
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Horiuchi
authors.forename: H
authors.initials: H
authors.lastname: Imanishi
authors.forename: Y
authors.initials: Y
authors.lastname: Odagaki
authors.forename: K
authors.initials: K
authors.lastname: Kawabata
authors.forename: T
authors.initials: T
authors.lastname: Sekioka
authors.forename: Y
authors.initials: Y
authors.lastname: Hirota
authors.forename: S
authors.initials: S
authors.lastname: Matsuoka
authors.forename: H
authors.initials: H
authors.lastname: Nakai
authors.forename: M
authors.initials: M
authors.lastname: Toda
authors.forename: J C
authors.initials: JC
authors.lastname: Cheronis
authors.forename: L W
authors.initials: LW
authors.lastname: Spruce
authors.forename: A
authors.initials: A
authors.lastname: Gyorkos
authors.forename: M
authors.initials: M
authors.lastname: Wieczorek
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018360:Crystallography, X-Ray; D004285:Dogs; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000882:Haplorhini; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; C419152:ONO 6818; D010069:Oxadiazoles; D011744:Pyrimidinones; D019272:Leukocyte Elastase