[Carbamazepine-induced hepatitis].
BACKGROUND
Hepatotoxic reactions associated with carbamazepine therapy are well recognised, and it is important that clinicians are aware of this adverse effect.


METHODS
We present the clinical course in three patients with carbamazepine-induced hepatitis.


RESULTS
All three patients had clinical and biochemical signs of hepatitis; improvement occurred immediately after carbamazepine therapy was discontinued. Other causes of hepatitis were excluded.


CONCLUSIONS
Previous reports concerning this adverse effect are reviewed. Focusing on the liver as the major organ for drug metabolism, we discuss possible pathophysiological mechanisms of drug-induced hepatic injury. A thorough medication history is mandatory in all patients with hepatitis and other liver diseases. The prognosis of carbamazepine-induced hepatitis is usually excellent, but fatal cases have been reported.
Haukeland
J W
JW
Avdeling for fordøyelsessykdommer Medisinsk klinikk, Aker Sykehus 0514 Oslo. johnwilly@os.telia.no
Jahnsen
J
J
Raknerud
N
N
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D000927:Anticonvulsants; D002220:Carbamazepine