Unusual pattern of leukoencephalopathy after morphine sulphate intoxication.
We report a 14-year-old girl with an unusual pattern of leukoencephalopathy after intentional intoxication with morphine sulphate tablets. Toxicological analysis showed exceedingly high levels of morphine and its metabolites. MRI disclosed a leukoencephalopathy with high signal from the centrum semiovale, corpus callosum and cerebellar white matter on T2-weighted images. These findings could be only partially explained by a hypoxic-ischaemic event; neurotoxic effects must be considered in this atypical leukoencephalopathy.
Nanan
R
R
Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. KINK106@mail.uni-wuerzburg.de
von Stockhausen
H B
HB
Petersen
B
B
Solymosi
L
L
Warmuth-Metz
M
M
D000293:Adolescent; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications / Q000209:etiology; D005260:Female; D006801:Humans; D007962:Leukocytes; D008279:Magnetic Resonance Imaging; D009020:Morphine / Q000506:poisoning*; D009294:Narcotics / Q000506:poisoning*; D009336:Necrosis; D020258:Neurotoxicity Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology
D009294:Narcotics; D009020:Morphine