Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle.
Modification of artemisinin structure led us to the discovery of a novel class of antitumor compounds. These artemisinin derivatives containing cyano and aryl groups showed potent antiproliferative effect in vitro against P388 and A549 cells. This activity was reflected in P388 murine leukemia by an accumulation of cells in G1 phase, and induction of apoptosis.
Li
Y
Y
Department of Synthetic Chemistry, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. yli@mail.shcnc.ac.cn
Shan
F
F
Wu
J M
JM
Wu
G S
GS
Ding
J
J
Xiao
D
D
Yang
W Y
WY
Atassi
G
G
Léonce
S
S
Caignard
D H
DH
Renard
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D037621:Artemisinins; D002455:Cell Division / Q000187:drug effects; D016193:G1 Phase / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin