ATP depletion + pyrimidine depletion can markedly enhance cancer therapy: fresh insight for a new approach.
Martin
D S
DS
Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Bertino
J R
JR
Koutcher
J A
JA
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017209:Apoptosis; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004247:DNA / Q000187:drug effects; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D016685:Mitomycin / Q000627:therapeutic use; D008954:Models, Biological; D009336:Necrosis; D009369:Neoplasms / Q000188:drug therapy*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011743:Pyrimidines / Q000378:metabolism*; D017382:Reactive Oxygen Species
D011743:Pyrimidines; D017382:Reactive Oxygen Species; D016685:Mitomycin; D004317:Doxorubicin; D000255:Adenosine Triphosphate; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases; D002945:Cisplatin