Diabetes mellitus secondary to glycogen storage disease type III.
BACKGROUND
Diabetes mellitus is a rare complication of glycogen storage disease type III (GSD III).


METHODS
We describe a 47-year-old man with GSD III who developed diabetes mellitus. He was diagnosed as having GSD III at the age of 18 years, and his glucose tolerance was normal at that time. Liver dysfunction and muscle atrophy gradually progressed, and the patient developed diabetes mellitus at the age of 45. When the post-prandial hyperglycaemia worsened, we instituted treatment with an alpha-glucosidase inhibitor, voglibose, and this improved glycaemic control without any adverse effects.


CONCLUSIONS
We recommend serial evaluation for complications of GSD III, and propose that an alpha-glucosidase inhibitor may be a favourable drug in treating diabetes mellitus secondary to GSD III.
Oki
Y
Y
Department of Endocrinology and Metabolism, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
Okubo
M
M
Tanaka
S
S
Nakanishi
K
K
Kobayashi
T
T
Murase
T
T
D017668:Age of Onset; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018450:Disease Progression; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006010:Glycogen Storage Disease Type III / Q000150:complications* / Q000503:physiopathology; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D002096:C-Peptide; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007328:Insulin; D007294:Inositol; C102817:voglibose