Effect of lupeol, a pentacyclic triterpene, on the lipid peroxidation and antioxidant status in rat kidney after chronic cadmium exposure.
This study pertains to the role of lupeol, a pentacyclic triterpene, against the toxic manifestations of chronic cadmium exposure. Cadmium is a potent nephrotoxin on prolonged exposure. Cadmium (as cadmium chloride) at a dose of 1 mg kg(-1) body weight was administered subcutaneously for 15 days to rats. This led to an increase in the level of lipid peroxides and a decrease in the level of antioxidants in the kidney. Lupeol, when supplemented at a dosage of 40 mg kg(-1) body weight concurrent with cadmium administration, showed an improvement in the antioxidant status. The level of lipid peroxides also showed a significant decrease, which shows the nephroprotective action of the drug.
Nagaraj
M
M
Department of Medical Biochemistry, Dr A.L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India.
Sunitha
S
S
Varalakshmi
P
P
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002105:Cadmium Poisoning / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D053978:Pentacyclic Triterpenes; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000633:toxicity*; D000094042:Lupanes
D000975:Antioxidants; D005609:Free Radicals; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes