title: Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia.
abstract: OBJECTIVE
  In patients with neutropenia, thoracic computed tomography (CT) halo and air-crescent signs are recognized as major indicators of invasive pulmonary aspergillosis (IPA). Nevertheless, the exact timing of CT images is not well known.
  
  
  METHODS
  Seventy-one thoracic CT scans were analyzed in 25 patients with neutropenia with surgically proven IPA.
  
  
  RESULTS
  On the first day of IPA diagnosis with early CT scan (d0), a typical CT halo sign was observed in 24 of 25 patients. At that time, the median number of thoracic lesions was two (range, one to six), and pulmonary involvement was bilateral in 12 cases. The halo sign was present in 68%, 22%, and 19% of cases on d3, d7, and d14, respectively. Similarly, the air-crescent sign was seen in 8%, 28%, and 63% of cases on the same days. Otherwise, a nonspecific air-space consolidation aspect was seen in 31%, 50%, and 18% of cases on the same days. The analysis of calculated aspergillary volumes on CT showed that, despite antifungal treatment, the median volume of lesions increased four-fold from d0 to d7, whereas it remained stable from d7 to d14. Overall, 21 patients (84%) were cured by the medical-surgical approach.
  
  
  CONCLUSIONS
  In patients with neutropenia, CT halo sign is a highly effective modality for IPA diagnosis. The duration of the halo sign is short, and it demonstrates the value of early CT. The increase of the aspergillosis size on CT in the first days after IPA diagnosis is not correlated with a pejorative immediate outcome when using a combined medical-surgical approach.
authors.affiliation: Department of Clinical Hematology, University Hospital of Dijon, Dijon, France. hemato.clinique@planetb.fr
authors.forename: D
authors.initials: D
authors.lastname: Caillot
authors.forename: J F
authors.initials: JF
authors.lastname: Couaillier
authors.forename: A
authors.initials: A
authors.lastname: Bernard
authors.forename: O
authors.initials: O
authors.lastname: Casasnovas
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
authors.forename: L
authors.initials: L
authors.lastname: Mannone
authors.forename: J
authors.initials: J
authors.lastname: Lopez
authors.forename: G
authors.initials: G
authors.lastname: Couillault
authors.forename: F
authors.initials: F
authors.lastname: Piard
authors.forename: O
authors.initials: O
authors.lastname: Vagner
authors.forename: H
authors.initials: H
authors.lastname: Guy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001228:Aspergillosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D001230:Aspergillus / Q000254:growth & development; D002648:Child; D002675:Child, Preschool; D019337:Hematologic Neoplasms / Q000150:complications / Q000382:microbiology*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology / Q000382:microbiology*; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed