title: Neobulgarones A approximately F from cultures of Neobulgaria pura, new inhibitors of appressorium formation of Magnaporthe grisea.
abstract: Six new dimeric anthraquinone derivatives, neobulgarones A (3a), B (3b), C (4a), D (4b), E (5a) and F (5b), were isolated from the mycelia of the ascomycete Neobulgaria pura together with the monomeric carviolin (1) and 1-O-methylemodin (2). All new compounds inhibited the formation of appressoria in germinating conidia of Magnaporthe grisea on inductive (hydrophobic) surface. The compounds exhibited moderate cytotoxic, but no antifungal, antibacterial, or phytotoxic activities.
authors.affiliation: Institute for Biotechnology and Drug Research, Kaiserslautern, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Eilbert
authors.forename: H
authors.initials: H
authors.lastname: Anke
authors.forename: O
authors.initials: O
authors.lastname: Sterner
mesh_terms: D000873:Anthracenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001203:Ascomycota / Q000254:growth & development / Q000378:metabolism*; D003470:Culture Media; D019281:Dimerization; D005285:Fermentation; D020082:Magnaporthe / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000873:Anthracenes; D000880:Anthraquinones; D000935:Antifungal Agents; D003470:Culture Media