title: Two new acetylenic derivatives and a new meroditerpenoid from a Taiwanese marine sponge Strongylophora durissima.
abstract: Further chemical examination of the sponge Strongylophora durissima yielded two new acetylenic derivatives, durissimols A (1) and B (2), and a new meroditerpenoid, strongylophorine-12 (5), in addition to the known acetylenic compounds, reneirin-2 (3), 18-hydroxyreneirin-2, melyne-C (4), duryne, siphanochalynol, and 24-ethylcholesterol (7). Among them, durissimol B (2) and duryne showed potent cytotoxicity against human gastric tumor (NUGC) cells.
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung 80424, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
authors.forename: Y C
authors.initials: YC
authors.lastname: Shen
authors.forename: C V
authors.initials: CV
authors.lastname: Prakash
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000480:Alkynes; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D004224:Diterpenes; C421066:durissimol A; C421065:durissimol B; C421067:strongylophorine-12; D000114:Acetylene