title: Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers.
abstract: Gemifloxacin and trovafloxacin were administered to 12 volunteers in a randomized crossover trial with a 2-week washout period. Stool samples were collected predose and 1, 2, and 3 days postdose. Both quinolones reduced the number of organisms of the family Enterobacteriaceae and aerobic gram-positive organisms. Escherichia coli reduction was greater with gemifloxacin than with trovafloxacin, with postdose isolation of quinolone-resistant strains for which MICs of trovafloxacin were higher than those of gemifloxacin.
authors.affiliation: Department of Medical Microbiology, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Garcia-Calvo
authors.forename: A
authors.initials: A
authors.lastname: Molleja
authors.forename: M J
authors.initials: MJ
authors.lastname: Giménez
authors.forename: A
authors.initials: A
authors.lastname: Parra
authors.forename: E
authors.initials: E
authors.lastname: Nieto
authors.forename: C
authors.initials: C
authors.lastname: Ponte
authors.forename: L
authors.initials: L
authors.lastname: Aguilar
authors.forename: F
authors.initials: F
authors.lastname: Soriano
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D004926:Escherichia coli / Q000187:drug effects; D005243:Feces / Q000382:microbiology*; D024841:Fluoroquinolones; D000077735:Gemifloxacin; D006801:Humans; D009287:Naphthyridines / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin; D000077735:Gemifloxacin