Skeletal muscle adaptation and cell cycle regulation.
During skeletal muscle adaptation to altered functional demands, quiescent satellite cells re-enter the cell cycle and subsequently differentiate into postmitotic myofibers. This process has fundamental importance for adaptation to exercise because the nuclei from satellite cells not only maintain a constant nuclear/cytoplasmic ratio, but also perhaps alter gene expression.
Yan
Z
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Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., NB11.208, Dallas, TX 75235-8573, USA. yan@ryburn.swmed.edu
D000222:Adaptation, Physiological; D002453:Cell Cycle; D002454:Cell Differentiation / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D018485:Muscle Fibers, Skeletal / Q000166:cytology / Q000502:physiology; D018482:Muscle, Skeletal / Q000166:cytology / Q000502:physiology*; D012038:Regeneration / Q000502:physiology