Elevated serum levels of soluble L-selectin in patients with systemic sclerosis declined after intravenous injection of lipo-prostaglandin E1.
To determine whether serum soluble L-selectin (sL-selectin) levels are elevated in patients with systemic sclerosis (SSc) and whether serum sL-selectin levels change after treatment with lipo-prostaglandin E1 (lipo-PGE1), serum sL-selectin levels were examined by ELISA in patients with SSc (n=24), psoriasis vulgaris (n=22), and contact dermatitis (n=9), as well as normal control subjects (n=26). In five patients with SSc, serum sL-selectin levels were examined before and after intravenous injections of lipo-PGE1. Serum sL-selectin levels were significantly increased in patients with SSc (P<0.01) than those in normal control subjects. The elevated serum sL-selectin levels in patients with SSc significantly decreased 1 day (P<0.05), 7 days (P<0.05) and 14 days (P<0.05) after starting the treatment with lipo-PGE1. These results suggest that L-selectin may be involved in the disease process in SSc, and lipo-PGE1 may alter some inflammatory events in SSc.
Inaoki
M
M
Department of Dermatology, Kanazawa University School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan. inaoki-m@med.kanazawa-u.ac.jp
Sato
S
S
Shimada
Y
Y
Takehara
K
K
D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000627:therapeutic use*; D002648:Child; D003877:Dermatitis, Contact / Q000097:blood; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D019041:L-Selectin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood; D012016:Reference Values; D012594:Scleroderma, Localized / Q000097:blood* / Q000188:drug therapy*; D012595:Scleroderma, Systemic / Q000097:blood* / Q000188:drug therapy*; D012995:Solubility
D019041:L-Selectin; D000527:Alprostadil