title: Evaluation of gamma thalamotomy for parkinsonian and other tremors: survival of neurons adjacent to the thalamic lesion after gamma thalamotomy.
abstract: OBJECTIVE
  The effects of gamma thalamotomy for parkinsonian and other kinds of tremor were evaluated.
  
  
  METHODS
  Thirty-six thalamotomies were performed in 31 patients by using a 4-mm collimator. The maximum dose was 150 Gy in the initial six cases, which was reduced to 130 Gy thereafter. The longest follow-up period was 6 years. The target was determined on T2-weighted and proton magnetic resonance (MR) images. The point chosen was in the lateral-most part of the thalamic ventralis intermedius nucleus. This is in keeping with open thalamotomy as practiced at the authors' institution. In 15 cases, gamma thalamotomy was the first surgical procedure. In other cases, previous therapeutic or vascular lesions were visible to facilitate targeting. Two types of tissue reaction were onserved on MR imaging: a simple oval shape and a complex irregular shape. Neither of these changes affected the clinical course. In the majority of cases, the tremor subsided after a latent interval of approximately 1 year after irradiation. The earliest response was demonstrated at 3 months. In five cases the tremor remained. In four of these cases, a second radiation session was administered. One of these four patients as well as another patient with an unsatisfactory result underwent open thalamotomy with microrecording. In both cases, depth recording adjacent to the necrotic area revealed normal neuronal activity, including the rhythmic discharge of tremor. Minor coagulation was performed and resulted in immediate and complete arrest of the remaining tremor.
  
  
  CONCLUSIONS
  Gamma thalamotomy for Parkinson's disease seems to be an alternative useful method in selected cases.
authors.affiliation: Functional and Gamma Knife Surgery Center, Hidaka Hospital, Takaski, Gunma, Japan. stereohe@showa.gunma-u.ac.jp
authors.forename: C
authors.initials: C
authors.lastname: Ohye
authors.forename: T
authors.initials: T
authors.lastname: Shibazaki
authors.forename: J
authors.initials: J
authors.lastname: Ishihara
authors.forename: J
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000175:diagnosis / Q000601:surgery*; D016634:Radiosurgery; D013788:Thalamus / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome; D014202:Tremor / Q000175:diagnosis / Q000601:surgery; D020651:Ventral Thalamic Nuclei / Q000473:pathology / Q000601:surgery