Transplantation of human fetal striatal tissue in Huntington's disease: rationale for clinical studies.
Huntington's disease is a fatal neurological disorder characterized by chorea and deterioration in cognitive and neuropsychiatric function. Primary pathological changes are found in the striatum, where GABAergic neurons undergo degenerative changes. Local interneurons are relatively spared. Here, we describe the rationale for clinical trials of fetal striatal tissue transplantation for the treatment of Huntington's disease. Specifically, the reasons for utilizing tissue derived from the far lateral aspect of the lateral ventricular eminence as a source of striatal tissue will be discussed.
Freeman
T B
TB
Department of Neurosurgery, University of South Florida, 4 Columbia Drive, Suite 730, Tampa, FL 33606, USA.
Hauser
R A
RA
Willing
A E
AE
Zigova
T
T
Sanberg
P R
PR
Saporta
S
S
D000818:Animals; D016380:Brain Tissue Transplantation; D002986:Clinical Trials as Topic; D003342:Corpus Striatum / Q000637:transplantation*; D016332:Fetal Tissue Transplantation; D006801:Humans; D006816:Huntington Disease / Q000601:surgery*