title: In vitro activity of new quinolones against Clostridium difficile.
abstract: We evaluated the in vitro activities of ofloxacin, levofloxacin, grepafloxacin, trovafloxacin and ciprofloxacin against Clostridium difficile. The MIC(90) was 128 mg/L for ofloxacin and levofloxacin, 64 mg/L for ciprofloxacin, 16 mg/L for grepafloxacin and 8 mg/L for trovafloxacin. Thirty per cent of isolates were resistant to trovafloxacin, and rates of resistance to ofloxacin, levofloxacin, grepafloxacin and ciprofloxacin were considerably higher. None of the antimicrobials studied would be a reliable therapeutic option against C. difficile. Whether some of the new fluoroquinolones can induce C. difficile-associated diarrhoea remains to be answered.
authors.affiliation: Servicio de Microbiología y Enfermedades Infecciosas, Hospital General Universitario 'Gregorio Marañón', C/Doctor Esquerdo 46, 28007 Madrid, Spain. ralonso@microb.net
authors.forename: R
authors.initials: R
authors.lastname: Alonso
authors.forename: T
authors.initials: T
authors.lastname: Peláez
authors.forename: M J
authors.initials: MJ
authors.lastname: González-Abad
authors.forename: L
authors.initials: L
authors.lastname: Alcalá
authors.forename: P
authors.initials: P
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez-Créixems
authors.forename: E
authors.initials: E
authors.lastname: Bouza
mesh_terms: D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D016360:Clostridioides difficile / Q000187:drug effects*; D003015:Clostridium Infections / Q000382:microbiology; D003967:Diarrhea / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents