Use of anti-infective agents during lactation: Part 1--Beta-lactam antibiotics, vancomycin, quinupristin-dalfopristin, and linezolid.
Because many antibiotics are excreted into the breast milk, it can be difficult for a practitioner to choose an antibiotic for a lactating patient that will have minimal risks to her nursing infant. This article is the first of a three-part series discussing the use of anti-infective agents during lactation. The authors review general information regarding use and common side effects of several classes of antibiotics. They also summarize information, including documented milk concentrations, milk-to-plasma ratios, and other pharmacokinetic properties, in a table that can help practitioners choose antibiotics that may be considered safe for the lactating mother.
Chin
K G
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University of Illinois at Chicago, Department of Pharmacy Practice, M/C 886, 833 S. Wood Street, Room 164, Chicago, IL 60612, USA.
Mactal-Haaf
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McPherson
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CE
D000081:Acetamides / Q000493:pharmacokinetics; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects*; D000069349:Linezolid; D008895:Milk, Human / Q000737:chemistry*; D009035:Mothers / Q000193:education; D023303:Oxazolidinones / Q000493:pharmacokinetics; D014640:Vancomycin / Q000493:pharmacokinetics; D014769:Virginiamycin / Q000493:pharmacokinetics; D047090:beta-Lactams
D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D047090:beta-Lactams; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D014640:Vancomycin; D000069349:Linezolid