title: [Results of oncological reoperation in primary soft tissue sarcomas].
abstract: BACKGROUND
  Soft tissue sarcomas (STS) are frequently resected incompletely or without an adequate margin. In such clinical situations an oncological re-resection (wide or compartmental resection or amputation) is recommended. Here, we evaluate the results of oncological re-resection for STS.
  
  
  METHODS
  Prospectively gathered data on 67 patients who underwent oncological re-resection after inadequate (intracapsular or marginal) surgery for primary soft tissue sarcomas were analyzed.
  
  
  RESULTS
  STS were located in the extremities (85%) and trunk (15%). Advanced UICC stages (1992, 4th edn., 2nd Rev.), IIB-IIIB predominated (66%). Twenty-five patients received intraoperative radiotherapy. Morbidity of re-resection was 28.4%. Residual tumor was detected in 64% of the specimens and clear margins were obtained in 60 patients (90%). With a median follow-up of 57 months the overall local control in patients with tumor-free resection margins was 88% (UICC IA-IIA 100%, IIB-IIIB 82%). Patients treated by adjuvant intraoperative radiotherapy for UICC stages IIB-IIIB with clear margins achieved 90% local control. The 5-year overall survival rate was 87% in patients with tumor-free resection margins.
  
  
  CONCLUSIONS
  These findings support the strategy of oncological re-resection after previously non-oncological surgery of STS and imply that re-resection is the prerequisite for any effective adjuvant therapy modality.
authors.affiliation: Chirurgische Klinik und Poliklinik, Universität Heidelberg.
authors.forename: M
authors.initials: M
authors.lastname: Schwarzbach
authors.forename: N
authors.initials: N
authors.lastname: Attigah
authors.forename: F
authors.initials: F
authors.lastname: Willeke
authors.forename: U
authors.initials: U
authors.lastname: Hinz
authors.forename: M
authors.initials: M
authors.lastname: van Kampen
authors.forename: G
authors.initials: G
authors.lastname: Mechtersheimer
authors.forename: T
authors.initials: T
authors.lastname: Lehnert
authors.forename: C
authors.initials: C
authors.lastname: Herfarth
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D005121:Extremities / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D012509:Sarcoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*