title: Comparison of the effects of bolus vs. slow infusion of 7.5% NaCl/6% dextran-70 in a model of near-lethal uncontrolled hemorrhage.
abstract: Bolus infusion of of 7.5% NaCl/6% dextran-70 (HSD-B) improves outcome from controlled hemorrhage. In contrast, HSD-B during uncontrolled hemorrhage increases bleeding and short-term mortality. The purpose of this study was to compare the effects of bolus vs. slow infusion of HSD in a near-fatal vascular injury hemorrhage model. Sixteen (15-20 kg) swine with 4-mm aortic tears were hemorrhaged to a pulse pressure of 5 mmHg. An ultrasonic flow probe was placed proximal to the aortic tear for continuous blood flow (AF) measurements. Group I (slow infusion; n = 8) was resuscitated with 8 mL/kg of HSD at 0.4 mL/kg/min. Group II (bolus infusion; n = 8) was resuscitated with 8 mL/kg of HSD at 1.33 mL/kg/min. In both groups, HSD infusion was followed by administration of 30 mL/kg of shed blood at 3 mL/kg/min. Hemorrhage volume and 90-min mortality were greater in group II (79+/-11 mL/kg; 75%) compared with group I (43+/-9 mL/kg; 12.5%) (P(Hem) < 0.001; P(Mort) = 0.04). Mean arterial pressure (MAP) and AF were greater in group II compared with group I during the first 15 min of resuscitation. In group I, MAP, AF, cardiac indices, and O2 delivery gradually returned to baseline levels and were significantly greater than group II at 30 min and throughout the remainder of the protocol. In this model of near-lethal uncontrolled hemorrhage, slow infusion of HSD restored cardiodynamics while minimizing hemorrhage volume and mortality. Resuscitation regimens that cause early increases in blood flow and pressure may result in greater hemorrhage and mortality than those regimens that yield comparable flow and pressure increases late in resuscitation.
authors.affiliation: Department of Emergency Medicine, University of Michigan Medical Center, Ann Arbor 48109-0303, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Stern
authors.forename: T
authors.initials: T
authors.lastname: Kowalenko
authors.forename: J
authors.initials: J
authors.lastname: Younger
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: S C
authors.initials: SC
authors.lastname: Dronen
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D003911:Dextrans / Q000008:administration & dosage; D004195:Disease Models, Animal; D005440:Fluid Therapy / Q000379:methods*; D006339:Heart Rate; D006470:Hemorrhage / Q000503:physiopathology / Q000628:therapy*; D007263:Infusions, Parenteral; D012151:Resuscitation / Q000379:methods*; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D013552:Swine; D013997:Time Factors
chemical_list: D003911:Dextrans; D012462:Saline Solution, Hypertonic