title: Successful treatment of hypothalamic seizures and precocious puberty with GnRH analogue.
abstract: Patients with hypothalamic hamartomas and precocious puberty may develop gelastic seizures that are resistant to conventional antiepileptic drug therapies. While treating precocious puberty in two such patients with long-acting GnRH analogue, the authors observed cessation of gelastic seizures. Although the mechanism is unclear, long-acting GnRH analogue should be considered as a possible therapy for gelastic seizures in patients with hypothalamic hamartomas.
authors.affiliation: Department of Neurology and Pediatric Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. mmzid@med.unc.edu
authors.forename: M
authors.initials: M
authors.lastname: Zaatreh
authors.forename: M
authors.initials: M
authors.lastname: Tennison
authors.forename: R S
authors.initials: RS
authors.lastname: Greenwood
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000188:drug therapy*; D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D006222:Hamartoma / Q000188:drug therapy*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy*
chemical_list: D007987:Gonadotropin-Releasing Hormone