The future of neuropathology in childhood.
The current state of knowledge of pediatric neuropathology is based upon a rich historical heritage dating back many centuries and representing the genius of many people, although, relatively speaking, little specific attention was paid to the unique issues relating to infants and children. Aside from descriptions of morphological features of disease (including tumors), advances in understanding basic pathogenetic mechanisms have flowered only in the recent past. Most exciting has been the progress in molecular biology and genetics, which has yielded a phenomenal bank of information in a short time, uncovering details of genes involved in development of the nervous system and specifically associated with various types of tumors. The future of pediatric neuropathology requires partnership with molecular geneticists whose studies hold promise of defining morphology.
Rorke
L B
LB
Children's Hospital of Philadelphia, 324 South 34th Street, Philadelphia, PA 19104, USA. Rorke@email.chop.edu
D000293:Adolescent; D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005544:Forecasting; D006801:Humans; D007223:Infant