Preoperative main portal branch transection combined with liver locoregional transarterial neo and adjuvant immunochemotherapy for patients with hepatocellular carcinoma.
OBJECTIVE
Main portal branch embolization was developed several years before in an attempt to improve prognosis and outcome for patients suffering from advanced liver malignancies.


METHODS
From September 1993 to September 2000 43 patients with advanced hepatocellular carcinoma underwent main portal branch transection and neo- and adjuvant transarterial immunochemotherapy. Forty days after initial surgery, all patients underwent a phase II surgical exploration for liver resection.


RESULTS
Survival ranged from 18 months to 64 months with a median of 41 months. Two- and 5-year survival was 75% and 57%, respectively.


CONCLUSIONS
Main portal branch transection combined with major liver resection and neoadjuvant and adjuvant locoregional immunochemotherapy fulfilled our expectations firstly for increasing the resectability rate and secondly for increasing the overall survival and the disease-free survival.
Lygidakis
N J
NJ
Department of Surgical Oncology, Athens Medical Center-Apollonion Hospital, Athens, Greece.
Sgourakis
G
G
Dedemadi
G
G
Spentzouris
N
N
Kontis
A
A
Nestoridis
J
J
D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000601:surgery / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D002763:Cholecystectomy; D003974:Diatrizoate Meglumine; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy / Q000379:methods*; D006499:Hepatic Artery; D006801:Humans; D007376:Interleukin-2 / Q000008:administration & dosage / Q000031:analogs & derivatives; D007459:Iodized Oil; D008026:Ligation; D008113:Liver Neoplasms / Q000098:blood supply / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D008942:Mitoxantrone / Q000008:administration & dosage; D020360:Neoadjuvant Therapy; D011994:Recombinant Proteins / Q000008:administration & dosage; D016019:Survival Analysis
D000970:Antineoplastic Agents; D007376:Interleukin-2; D011994:Recombinant Proteins; D003974:Diatrizoate Meglumine; D016685:Mitomycin; D007459:Iodized Oil; D008942:Mitoxantrone; C082598:aldesleukin; D005472:Fluorouracil