title: Th1 and Th2 cells.
abstract: After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells. Transcription factors and signaling pathways that are selectively expressed or activated in Th1 and Th2 cells to regulate cytokine gene expression are discussed.
authors.affiliation: Department of Immunology, University of Washington School of Medicine, Seattle, USA.
authors.forename: C
authors.initials: C
authors.lastname: Dong
authors.forename: R A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology*; D015398:Signal Transduction; D018417:Th1 Cells / Q000502:physiology*; D018418:Th2 Cells / Q000502:physiology*