title: [Lys3]Didemnins as potential affinity ligands.
abstract: The synthesis and biological activity of N(epsilon)-Z-[Lys3]didemnin B are reported. This novel analogue retains antiproliferative, cytotoxic, and protein biosynthesis inhibition activities, but at reduced levels. This result suggests the use of [Lys3]didemnin derivatives as potential affinity probes for studying the molecular target(s) of the didemnin class of natural products.
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia 19104-6323, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Vera
authors.forename: A J
authors.initials: AJ
authors.lastname: Pfizenmayer
authors.forename: X
authors.initials: X
authors.lastname: Ding
authors.forename: D
authors.initials: D
authors.lastname: Xiao
authors.forename: M M
authors.initials: MM
authors.lastname: Joullié
mesh_terms: D000345:Affinity Labels / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D047630:Depsipeptides; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology / Q000633:toxicity; D014176:Protein Biosynthesis; D014407:Tumor Cells, Cultured
chemical_list: D000345:Affinity Labels; D047630:Depsipeptides; D008024:Ligands; D010456:Peptides, Cyclic; C030051:didemnins