Acinetobacter baumannii at a tertiary-care teaching hospital in Jerusalem, Israel.
In a retrospective 10-year analysis of 3,536 patient-unique isolates, Acinetobacter baumannii imipenem susceptibility declined from 98.1 (1990) to 64.1% (2000), and ciprofloxacin susceptibility decreased from 50.5 to 13.1%. Imipenem median zone diameters decreased from 27. 7 (1997) to 18.8 mm (2000). No outbreaks were detected. Two clusters were identified for 41 strains genotyped by pulsed-field gel electrophoresis, but imipenem resistance was not clonal.
Simhon
A
A
Department of Clinical Microbiology & Infectious Diseases, Hadassah-University Hospital, Jerusalem, Israel. simhon@hadassah.org.il
Rahav
G
G
Shazberg
G
G
Block
C
C
Bercovier
H
H
Shapiro
M
M
D000150:Acinetobacter / Q000187:drug effects* / Q000235:genetics; D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D006784:Hospitals, Teaching; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007557:Israel / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D013845:Thienamycins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013845:Thienamycins; D002939:Ciprofloxacin; D015378:Imipenem