Nitroimidazoles and hypoxia imaging: synthesis of three technetium-99m complexes bearing a nitroimidazole group: biological results.
Several Tc-99m complexes were synthesized, substituted with a nitroimidazole group, in order to visualize hypoxic tissues. The complexes were tested on rats (isolated hearts) and showed no significant uptake under hypoxic conditions.
Riché
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Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité, Université Joseph Fourier, UMR 5616-BP 53, Grenoble, France. francoise.riche@ujf-grenoble.fr
d'Hardemare
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AD
Sèpe
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Riou
L
L
Fagret
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D
Vidal
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D000818:Animals; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D000860:Hypoxia / Q000000981:diagnostic imaging*; D066298:In Vitro Techniques; D008024:Ligands; D015394:Molecular Structure; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010477:Perfusion; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000378:metabolism; D017556:Technetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
D008024:Ligands; D009593:Nitroimidazoles; D017556:Technetium Compounds; D013667:Technetium