title: Factors V leiden and II 20210A in patients with symptomatic pulmonary embolism and deep vein thrombosis.
abstract: OBJECTIVE
  Factor V Leiden and factor II 20210A are inherited disorders of the clotting system that occur frequently in patients with deep vein thrombosis. We conducted this study to determine whether these factors are also common in patients with pulmonary embolism.
  
  
  METHODS
  We determined the prevalence of factor V Leiden and factor II 20210A in 773 consecutive patients with objectively documented symptomatic deep vein thrombosis or symptomatic pulmonary embolism, or with a combination of these disorders.
  
  
  RESULTS
  Isolated symptomatic deep vein thrombosis occurred in 345 patients; isolated symptomatic pulmonary embolism occurred in 236; and both anomalies occurred in 192. Factor V Leiden was present in 21 (9%) of the patients with isolated symptomatic pulmonary embolism, in 30 (16%) with both manifestations, and in 63 (18%) with isolated symptomatic deep vein thrombosis (P = 0.007). Factor V Leiden was more common among patients with deep vein thrombosis (odds ratio [OR] = 2.1; 95% confidence interval [CI]: 1.2 to 3.7; P = 0.006) or both pulmonary embolism and deep vein thrombosis (OR = 1.8; 95% CI: 1.0 to 3.3; P = 0.07) than among patients with isolated pulmonary embolism. Factor V Leiden was less common in massive pulmonary embolism (5% [7 of 127]) than in submassive pulmonary embolism (13% [21 of 155], P = 0.03). We found no significant difference in the prevalence of factor II 20210A among the three groups.
  
  
  CONCLUSIONS
  Factors V Leiden and II 20210A vary in prevalence among patients with pulmonary embolism and deep vein thrombosis, suggesting that the risk of pulmonary embolization may vary among patients who have different causes of venous thromboses.
authors.affiliation: Service de Pneumologie-réanimation (GM, HS), Hôpital Laennec, Université Paris V, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Emmerich
authors.forename: D
authors.initials: D
authors.lastname: Helley
authors.forename: E
authors.initials: E
authors.lastname: Arnaud
authors.forename: V
authors.initials: V
authors.lastname: Nicaud
authors.forename: M
authors.initials: M
authors.lastname: Alhenc-Gelas
authors.forename: M
authors.initials: M
authors.lastname: Aiach
authors.forename: A
authors.initials: A
authors.lastname: Fischer
authors.forename: H
authors.initials: H
authors.lastname: Sors
authors.forename: J N
authors.initials: JN
authors.lastname: Fiessinger
mesh_terms: D000328:Adult; D000368:Aged; D005165:Factor V / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011516:Prothrombin / Q000378:metabolism*; D011655:Pulmonary Embolism / Q000097:blood* / Q000150:complications; D020246:Venous Thrombosis / Q000097:blood* / Q000150:complications
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; C025337:Factor IIa