Sesquiterpene lactones from Centaurea thessala and Centaurea attica. Antifungal activity.
The aerial parts of Centaurea thessala ssp. drakiensis and C. attica ssp. attica afforded, in addition to several known sesquiterpene lactones, two new eudesmanolides, 4-epi-sonchucarpolide and its 8-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) derivative and one new eudesmane derivative, named atticin. The in vitro antifungal activity of most compounds was tested against nine fungal species, using the micro-dilution method. All the compounds tested showed great antifungal activity.
Skaltsa
H
H
Department of Pharmacognosy, School of Pharmacy, University of Athens, Greece. skaltsa@pharm.uoa.gr
Lazari
D
D
Panagouleas
C
C
Georgiadou
E
E
Garcia
B
B
Sokovic
M
M
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D019659:Asteraceae / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
D000935:Antifungal Agents; D007783:Lactones; D012717:Sesquiterpenes