Serum S-100beta protein is a potential biochemical marker for cerebral oedema complicating severe diabetic ketoacidosis.
METHODS
A 39-year-old man with Type 1 diabetes mellitus was hospitalized with severe diabetic ketoacidosis (DKA). Sixteen hours after admission he suddenly deteriorated having a respiratory then cardiac arrest. A brain computed tomography scan performed 2 h after the respiratory arrest showed severe cerebral oedema. Serial serum samples were stored and analysed for S-100beta protein. The S-100beta protein concentration was initially normal (0.12 microg/l) then rose significantly before the onset of the respiratory arrest (8.5 h = 0.61 microg/l, 14.5 h = 0.9 microg/l, 18 h = 1.6 microg/l, 25.5 h = 3.1 microg/l, 34 h = 4.6 microg/l and44 h = 19.5 microg/l).


CONCLUSIONS
In this case of DKA, serum S-100beta concentration rose coinciding with the onset of cerebral oedema, before it became clinically evident. Monitoring serum S-100beta may have a useful role in the management of DKA.
McIntyre
E A
EA
Medical Unit 3, Freeman Hospital, Newcastle upon Tyne, UK. E.A.Mcintyre@ncl.ac.uk
Abraha
H D
HD
Perros
P
P
Sherwood
R A
RA
D000328:Adult; D001324:Autoantigens / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000000981:diagnostic imaging; D001929:Brain Edema / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D002135:Calcium-Binding Proteins / Q000097:blood*; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D005440:Fluid Therapy; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D014057:Tomography, X-Ray Computed
D001324:Autoantigens; D015415:Biomarkers; D002135:Calcium-Binding Proteins; D007328:Insulin; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins