title: Collagenases in different categories of peri-implant vertical bone loss.
abstract: The loosening of dental implants is associated with peri-implant vertical bone loss. The mechanisms and mediators of this bone destruction are not known. To test the hypothesis that collagenase-2 and collagenase-3 might be markers or maybe even mediators in this process, we measured collagenase-2 (time-resolved immunofluorometric assay) and collagenase-3 (quantitative immunoblot) in peri-implant sulcus fluid in 49 implant sites in 13 patients. Vertical bone loss was graded as being < 1 mm, from 1 to 3 mm, or > 3 mm. The severity of inflammation, as rated according to Gingival Index, did not correlate with the category of bone loss (p > 0.05). Collagenase-2 and collagenase-3 were higher (p < 0.05) in the group which had lost > 3 mm of bone than in the two other groups. Gingival Index is not a clinically important marker for bone loss, but collagenase-2 and collagenase-3 in peri-implant sulcus fluid are. They might participate in peri-implant osteolysis.
authors.affiliation: Department of Anatomy, Institute of Biomedicine, University of Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Ma
authors.forename: U
authors.initials: U
authors.lastname: Kitti
authors.forename: O
authors.initials: O
authors.lastname: Teronen
authors.forename: T
authors.initials: T
authors.lastname: Sorsa
authors.forename: V
authors.initials: V
authors.lastname: Husa
authors.forename: P
authors.initials: P
authors.lastname: Laine
authors.forename: H
authors.initials: H
authors.lastname: Rönkä
authors.forename: T
authors.initials: T
authors.lastname: Salo
authors.forename: C
authors.initials: C
authors.lastname: Lindqvist
authors.forename: Y T
authors.initials: YT
authors.lastname: Konttinen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016301:Alveolar Bone Loss / Q000201:enzymology* / Q000209:etiology*; D017364:Collagenases / Q000378:metabolism*; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects*; D019232:Dental Restoration Failure; D005260:Female; D005883:Gingival Crevicular Fluid / Q000201:enzymology; D006801:Humans; D008297:Male; D053509:Matrix Metalloproteinase 13; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism; D008875:Middle Aged; D010512:Periodontal Index; D018709:Statistics, Nonparametric
chemical_list: D015921:Dental Implants; D017364:Collagenases; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; D020784:Matrix Metalloproteinase 8