Genetics of surface antigen expression in Pneumocystis carinii.
This article reviews the molecular genetic data pertaining to the major surface glycoprotein (MSG) gene family of Pneumocystis carinii and its role in surface variation and compares this fungal system to antigenic variation systems in the protozoan Trypanosoma brucei and the bacteria Borrelia spp.
Stringer
J R
JR
Department of Molecular Genetics, Biochemistry, and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA. stringjr@ucmail.uc.edu
Keely
S P
SP
D001898:Borrelia / Q000276:immunology; D002874:Chromosome Mapping; D005656:Fungal Proteins / Q000235:genetics* / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000502:physiology; D011010:Pneumocystis / Q000235:genetics / Q000276:immunology*; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics
D005656:Fungal Proteins; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D014643:Variant Surface Glycoproteins, Trypanosoma; C077556:GPA protein, Pneumocystis carinii sp.