title: [Optimality of enzymatic physiological systems].
abstract: An optimality criterion is proposed for physiological systems based on limited proteolysis. The proposed criterion is applied to the prourokinase-activated fibrinolytic system, for which the existence of optimal (according to this criterion) substrate concentrations is demonstrated. It is also shown that the optimal substrate concentrations depend on the values of kinetic constants.
authors.affiliation: Russian State Technological University, Orshanskaya ul. 3, Moscow, 121552 Russia.
authors.forename: K V
authors.initials: KV
authors.lastname: Tiurin
authors.forename: M A
authors.initials: MA
authors.lastname: Khanin
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D004798:Enzymes / Q000378:metabolism*; D005342:Fibrinolysis; D007700:Kinetics; D008954:Models, Biological; D010960:Plasminogen Activators / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D004798:Enzymes; D011498:Protein Precursors; D011506:Proteins; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator