title: Anti-inflammatory response of IL-4, IL-10 and TGF-beta in patients with systemic inflammatory response syndrome.
abstract: The systemic inflammatory response syndrome (SIRS) is an inflammatory process seen in association with a large number of clinical infective and non-infective conditions. The aim of this study was to investigate the role of anti-inflammatory cytokines such as interleukin-4 (IL-4), interleukin-10 (IL-10), and transforming growth factor-beta (TGF-beta). Serum levels of IL-4, IL-10 and TGF-beta were determined in 45 patients with SIRS: 38 patients had SIRS of infectious origin, whereas seven patients had non-infectious SIRS. Twenty healthy subjects were used as controls. Serum levels of IL-4, IL-10 and TGF-beta were determined by an immunoenzyme assay. A significant increase of IL-4 was observed in these patients at the time of diagnosis and 5 days later. In contrast, serum levels of IL-10 were not increased at the time of diagnosis, but a slight decrease was noted after 5 days. Serum levels of TGF-beta were not increased at time of diagnosis, and a slight increase was observed after 5 days. Serum levels of IL-4 were significantly higher in patients with infectious SIRS at the time of diagnosis, whereas no significant difference between infectious and non-infectious SIRS was noted for serum levels of IL-10 and TGF-beta at the time of diagnosis and 5 days later. During SIRS, serum levels of IL-4 were significantly increased with a significant correlation between IL-4 and mortality, and only levels of IL-4 were significantly increased in the SIRS caused by infectious stimuli.
authors.affiliation: Division of Infectious Diseases, Regional Hospital, Varese, Italy. eiwle@tin.it
authors.forename: D
authors.initials: D
authors.lastname: Torre
authors.forename: R
authors.initials: R
authors.lastname: Tambini
authors.forename: S
authors.initials: S
authors.lastname: Aristodemo
authors.forename: G
authors.initials: G
authors.lastname: Gavazzeni
authors.forename: A
authors.initials: A
authors.lastname: Goglio
authors.forename: C
authors.initials: C
authors.lastname: Cantamessa
authors.forename: A
authors.initials: A
authors.lastname: Pugliese
authors.forename: G
authors.initials: G
authors.lastname: Biondi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007239:Infections / Q000097:blood; D018836:Inflammation Mediators / Q000378:metabolism; D016753:Interleukin-10 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood*; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D018836:Inflammation Mediators; D016212:Transforming Growth Factor beta; D016753:Interleukin-10; D015847:Interleukin-4