title: Determination of the relative and absolute stereochemistry of a potent and alpha1A-selective adrenoceptor antagonist.
abstract: The binding affinities and selectivities of antagonists 1-4 for the alpha1A-adrenoceptor are dependent on the stereochemical orientation of the groups at the C-4 and C-5 positions of the oxazolidinone ring. The unambiguous assignment of the relative and absolute configurations of the diastereomers of SNAP 7915 (1) is reported.
authors.affiliation: Department of Chemistry, Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA. blagu@prius.jnj.com
authors.forename: B
authors.initials: B
authors.lastname: Lagu
authors.forename: J M
authors.initials: JM
authors.lastname: Wetzel
authors.forename: C
authors.initials: C
authors.lastname: Forray
authors.forename: M A
authors.initials: MA
authors.lastname: Patane
authors.forename: M G
authors.initials: MG
authors.lastname: Bock
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010080:Oxazoles / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D010080:Oxazoles; C412726:SNAP 7915