title: Synthesis and theoretical study of 2-amino-2,3,3a,4,5,6-hexahydro-1H-phenalene and its biological evaluation on central dopaminergic system.
abstract: Compound 2 considered as a rigid non-hydroxylated 2-amino tetralin was synthesized and biologically evaluated. Central administration of compound 2 (50 microg or 100 microg/10 microl) induced a reduction in urinary sodium and potassium excretion at 3 and 6 h of urine collection. We speculate that compound 2 may be acting as a dopamine receptor antagonist.
authors.affiliation: Laboratorio de Síntesis Orgánica y Diseño Molecular, Departamento de Química, Facultad Experimental de Ciencias, Universidad del Zulia, Maracaibo, Venezuela. jangel@luz.ve
authors.forename: J E
authors.initials: JE
authors.lastname: Angel-Guío
authors.forename: J E
authors.initials: JE
authors.lastname: Charris
authors.forename: J
authors.initials: J
authors.lastname: Pérez
authors.forename: Z D
authors.initials: ZD
authors.lastname: Duerto de Pérez
authors.forename: R
authors.initials: R
authors.lastname: Compagnone
authors.forename: A
authors.initials: A
authors.lastname: Israel
authors.forename: L
authors.initials: L
authors.lastname: Orfila
authors.forename: B
authors.initials: B
authors.lastname: Migliore de Angel
authors.forename: S E
authors.initials: SE
authors.lastname: López
authors.forename: L
authors.initials: L
authors.lastname: Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Caldera
authors.forename: E
authors.initials: E
authors.lastname: Michelena de Báez
authors.forename: F
authors.initials: F
authors.lastname: Arrieta
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D018492:Dopamine Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009318:Natriuresis / Q000187:drug effects; D043803:Phenalenes; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D012964:Sodium / Q000652:urine
chemical_list: C430450:2-amino-2,3,3a,4,5,6-hexahydro-1H-phenalene; D000588:Amines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D006571:Heterocyclic Compounds; D043803:Phenalenes; D011083:Polycyclic Compounds; D017447:Receptors, Dopamine D1; D012964:Sodium; D011188:Potassium