BRCA1 and cell signaling.
The breast cancer and ovarian cancer susceptibility gene BRCA1 encodes a nucleoprotein whose mutations or aberrant expression is associated with both inherited and sporadic cancers. Studies over the last 6 years have suggested that BRCA1 may function as a scaffold in the assembly of a multi-protein complex, which plays a role in gene transcription, DNA damage repair, and transcription-coupled DNA damage repair. In this review, we discuss the implications drawn from the studies of BRCA1-interacting proteins and the cellular signaling pathways that may be involved in controlling the functions of BRCA1.
Wang
Q
Q
Department of Pathology and Laboratory Medicine, The University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Zhang
H
H
Fishel
R
R
Greene
M I
MI
D000818:Animals; D017209:Apoptosis; D019313:BRCA1 Protein / Q000502:physiology*; D002453:Cell Cycle; D020090:Chromosome Segregation; D004249:DNA Damage; D004260:DNA Repair; D005786:Gene Expression Regulation; D006801:Humans; D015398:Signal Transduction
D019313:BRCA1 Protein