Surfactant and surfactant inhibitors in meconium aspiration syndrome.
Surfactant indices and inhibitors were measured in lung lavage fluid from 8 infants with meconium aspiration syndrome (MAS) who were receiving mechanical ventilation and 11 healthy control subjects. Surfactant phospholipid and surfactant protein A content in MAS was not different from that of control subjects, but concentrations of total protein, albumin, and membrane-derived phospholipid were elevated. All infants with MAS had hemorrhagic pulmonary edema. These findings reinforce the notion of MAS as a toxic pneumonitis with epithelial disruption and proteinaceous exudation.
Dargaville
P A
PA
Department of Neonatology and University Department of Paediatrics, Royal Children's Hospital, Melbourne, Australia.
South
M
M
McDougall
P N
PN
D000418:Albumins / Q000032:analysis; D001784:Blood Gas Analysis; D001806:Blood Urea Nitrogen; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D016022:Case-Control Studies; D005865:Gestational Age; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008471:Meconium Aspiration Syndrome / Q000097:blood / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D010743:Phospholipids / Q000032:analysis; D010953:Plasma Volume; D011506:Proteins / Q000032:analysis; D011510:Proteolipids / Q000032:analysis; D011654:Pulmonary Edema / Q000209:etiology; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000032:analysis* / Q000037:antagonists & inhibitors*; D012121:Respiration, Artificial / Q000379:methods; D013997:Time Factors
D000418:Albumins; D010743:Phospholipids; D011506:Proteins; D011510:Proteolipids; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants