title: Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities.
abstract: The fruits of Neoraptua magnifica var. magnifica afforded three new flavonoids: 2'-hydroxy-4,4',-dimethoxy-5',6'-(2'',2''-dimethylpyrano)chalcone, 2'-hydroxy-3,4,4'-trimethoxy-5',6'-(2'',2''-dimethylpyrano)chalcone, and 3',4'-methylenedioxy-5,7-dimethoxyflavone which were identified on the basis of spectroscopic methods. The known flavonoids 2'-hydroxy-3,4,4',5-tetramethoxy-5',6'-(2'',2''-dimethylpyrano)chalcone, 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone, 3',4'-methylenedioxy-5,6,7-trimethoxyflavone, 3',4'-methylenedioxy-5',5,6,7-tetramethoxyflavone, 3',4',5',5,7-pentamethoxyflavanone and 3',4',5'5,7-pentamethoxyflavone were also identified. The latter flavone was the most active as glyceraldehyde-3-phosphate dehydrogenase-inhibitor.
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, SP, Brazil.
authors.forename: D M
authors.initials: DM
authors.lastname: Tomazela
authors.forename: M T
authors.initials: MT
authors.lastname: Pupo
authors.forename: E A
authors.initials: EA
authors.lastname: Passador
authors.forename: M F
authors.initials: MF
authors.lastname: da Silva
authors.forename: P C
authors.initials: PC
authors.lastname: Vieira
authors.forename: J B
authors.initials: JB
authors.lastname: Fernandes
authors.forename: E R
authors.initials: ER
authors.lastname: Fo
authors.forename: G
authors.initials: G
authors.lastname: Oliva
authors.forename: J R
authors.initials: JR
authors.lastname: Pirani
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D019685:Rosales / Q000737:chemistry*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D011994:Recombinant Proteins; D014344:Trypanocidal Agents; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases