ACE and alpha-adducin genotypes and renal disease progression.
In the REIN study of non-diabetic proteinuric nephropathies, renal disease progression was independent of the angiotensin-converting enzyme (ACE) and alpha-adducin genotypes. However, the ACE genotype predicted the renoprotective effect of ACE inhibition. Subgroup analysis in patients with Berger disease showed a tendency (NS) for a faster progression in DD homozygotes.
Zoccali
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CNR Centro Fisiologia Clinica e Unità Operativa di Nefrologia, Dialisi e Trapianto Renale, Reggio Calabria, Italy.
D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D018450:Disease Progression; D005838:Genotype; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics / Q000503:physiopathology*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000502:physiology; D000099291:Adducins
D002148:Calmodulin-Binding Proteins; D007703:Peptidyl-Dipeptidase A; D000099291:Adducins