title: Substituted 1,6-naphthyridines as human cytomegalovirus inhibitors: conformational requirements.
abstract: Substituted 1,6-naphthyridine derivatives, a new class of human cytomegalovirus inhibitors, were prepared to demonstrate the role of intramolecular hydrogen bonds to maintain the compounds in their active conformation.
authors.affiliation: BioChem Pharma Inc., Laval, Québec, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Falardeau
authors.forename: L
authors.initials: L
authors.lastname: Chan
authors.forename: T
authors.initials: T
authors.lastname: Stefanac
authors.forename: S
authors.initials: S
authors.lastname: May
authors.forename: H
authors.initials: H
authors.lastname: Jin
authors.forename: J F
authors.initials: JF
authors.lastname: Lavallée
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D009287:Naphthyridines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D009287:Naphthyridines