title: [High-dose thiotepa chemotherapy in children].
abstract: High-dose thiotepa (800-900 mg/m2) polychemotherapy following combined treatment resulted in high toxicity and lethality. 600 mg/m2 proved optimal for double-conditioning regimens since it exerted antitumor effect without causing fatal complications.
authors.affiliation: N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: D G
authors.initials: DG
authors.lastname: Izhogin
authors.forename: V K
authors.initials: VK
authors.lastname: Boiarshinov
authors.forename: I S
authors.initials: IS
authors.lastname: Dolgonolov
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Iankelevich
authors.forename: E A
authors.initials: EA
authors.lastname: Ptushkina
authors.forename: G L
authors.initials: GL
authors.lastname: Mentkevich
mesh_terms: D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D016019:Survival Analysis; D013852:Thiotepa / Q000008:administration & dosage* / Q000009:adverse effects*; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000188:drug therapy*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D013852:Thiotepa