title: The use of topical diphenylcyclopropenone for the treatment of extensive alopecia areata.
abstract: BACKGROUND
  Highly variable results of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata have been reported so far.
  
  
  OBJECTIVE
  The purposes of our study were to evaluate the efficacy and tolerability of DPCP in the treatment of chronic, extensive alopecia areata and to assess the long-term overall benefit of treatment.
  
  
  METHODS
  Fifty-six patients with chronic, extensive alopecia areata were enrolled in an open-label clinical trial. After sensitization with 2% DPCP, progressively higher concentrations beginning at 0.001% were applied weekly for 6 to 12 months to one side of the scalp.
  
  
  RESULTS
  Fifty-two of 56 patients completed therapy. Total regrowth of terminal hair was achieved in 25 of 52 patients (48%) at 6 months. The most frequent side effect was an eczematous reaction at the site of application. Notably, persistent response was observed in 60% of these patients after 6 to 18 months of follow-up (mean, 12 months).
  
  
  CONCLUSIONS
  Topical DPCP treatment for alopecia areata is effective and well tolerated and provides prolonged therapeutic benefits.
authors.affiliation: Department of Dermatology, University of L'Aquila, Italy. chimenti@univaq.it
authors.forename: C
authors.initials: C
authors.lastname: Cotellessa
authors.forename: K
authors.initials: K
authors.lastname: Peris
authors.forename: E
authors.initials: E
authors.lastname: Caracciolo
authors.forename: C
authors.initials: C
authors.lastname: Mordenti
authors.forename: S
authors.initials: S
authors.lastname: Chimenti
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000506:Alopecia Areata / Q000188:drug therapy*; D002908:Chronic Disease; D003521:Cyclopropanes / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D003521:Cyclopropanes; C029402:diphenylcyclopropenone