Gamma knife radiosurgery for pituitary adenomas.
OBJECTIVE
The purpose of this study was the analysis of a large series of patients treated with gamma knife radiosurgery for pituitary adenoma in a single institution.


METHODS
One hundred eight patients with pituitary adenomas were treated over the last 7 years. Seventy-four patients have been followed for more than 6 months and form the basis of this report.


CONCLUSIONS
Twenty-three patients harbored nonfunctioning adenomas, and 56 harbored functioning adenomas. The mean margin dose was 22.5 Gy (nonfunctioning adenomas, 19.5 Gy; functioning adenomas, 23.8 Gy). Control of tumor growth was achieved in 91%. A significant decrease of excessive hormone production was seen in 80% of patients, and the endocrinological normalization rate was 30.3%. Postradiosurgical complications were seen in 2.5%.
Izawa
M
M
Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Japan. mizawa@nij.twmu.ac.jp
Hayashi
M
M
Nakaya
K
K
Satoh
H
H
Ochiai
T
T
Hori
T
T
Takakura
K
K
D000236:Adenoma / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D016634:Radiosurgery; D016896:Treatment Outcome