Acute effects of sildenafil (viagra) on blue-on-yellow and white-on-white Humphrey perimetry.
OBJECTIVE
To study the effects of sildenafil on blue-on-yellow and white-on-white Humphrey visual field (HVF).


METHODS
Healthy subjects, ages 20 to 38 years, were prospectively randomized to active drug (n = 5) or placebo (n = 3) groups. Blue-on-yellow and white-on-white HVF testing was performed before and 1 hour after masked dosing of sildenafil 200 mg or placebo. Changes in mean deviation (MD) were compared between groups.


RESULTS
Three of three placebo and four of five sildenafil subjects had no change on HVF. One of five sildenafil subjects had a decrease in MD of 17.9 dB and 4.7 dB on blue-on-yellow and white-on-white HVF testing, respectively. This subject reported more systemic side effects than other subjects.


CONCLUSIONS
Sildenafil has no effect on HVF testing in most persons; however, sildenafil caused an acute abnormality of HVF testing in one subject, who experienced pronounced non-visual systemic symptoms; this effect was greater on blue-on-yellow than white-on-white HVF.
McCulley
T J
TJ
Bascom Palmer Eye Institute, University of Miami, Florida, USA.
Lam
B L
BL
Marmor
M F
MF
Hoffman
K B
KB
Luu
J K
JK
Feuer
W J
WJ
D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D011446:Prospective Studies; D011687:Purines; D012160:Retina / Q000187:drug effects; D000068677:Sildenafil Citrate; D013450:Sulfones; D058609:Visual Field Tests; D014794:Visual Fields / Q000187:drug effects*
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D015106:3',5'-Cyclic-GMP Phosphodiesterases