Effect of medroxyprogesterone acetate plus estradiol on endothelium-dependent vasodilation in postmenopausal women.
The addition of medroxyprogesterone acetate (MPA) is widely accepted to remove the endometrial-cancerogenic effect of estrogen replacement therapy in postmenopausal women. To evaluate the effect of MPA on endothelial function, we measured flow-mediated vasodilation of brachial arteries after transient occlusion in a randomized, double-blind, placebo-controlled study; we concluded that the addition of MPA attenuates the favorable effects of estradiol on endothelium-dependent vasodilation.
Kawano
H
H
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan. koumei@gpo.kumamoto-u.ac.jp
Motoyama
T
T
Hirai
N
N
Yoshimura
T
T
Kugiyama
K
K
Ogawa
H
H
Okamura
H
H
Yasue
H
H
D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000517:prevention & control; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D008055:Lipids / Q000097:blood; D008525:Medroxyprogesterone / Q000494:pharmacology*; D017698:Postmenopause; D045167:Progesterone Congeners / Q000494:pharmacology*; D018608:Ultrasonography, Doppler; D014664:Vasodilation / Q000187:drug effects*
D008055:Lipids; D045167:Progesterone Congeners; D004958:Estradiol; D008525:Medroxyprogesterone