Effects of amantadine on modification of dopamine dependent behaviours by molindone.
Amantadine, a dopamine agonist is reported to act by releasing dopamine from the dopaminergic nerve terminals as an anti-Parkinsonian drug. In the present behavioural study in the rat, molindone-induced catalepsy and ptosis, which are dopamine dependent-behaviors are reversed by amantadine. Amantadine has also revered molindone-induced inhibition of traction response in mice. Our study indicates that amantadine, like other DA agonists, e.g. amphetamine and apomorphine can antagonize or even reverse the neuroleptic induced dopaminergic behaviors.
Dhaware
B S
BS
Department of Pharmacology, Padmashree Dr. DY Patil Medical College for Women, Pimpri, Pune 411018.
Balsara
J J
JJ
Nandal
N V
NV
Chandorkar
A G
AG
D000547:Amantadine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001763:Blepharoptosis / Q000209:etiology / Q000517:prevention & control; D002375:Catalepsy / Q000139:chemically induced / Q000150:complications / Q000378:metabolism / Q000517:prevention & control*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008972:Molindone; D011336:Probability; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013045:Species Specificity
D015259:Dopamine Agents; D000547:Amantadine; D008972:Molindone; D004298:Dopamine