[From allergic rhinitis to sinus diseases (sinusitis/nasal polyps): epidemiologic and experimental links].
The relationships between rhinitis and chronic sinusitis are close and complex, those between allergic rhinitis and nasal polyposis are controversial. These relationships can be demonstrated not only in terms of anatomy, physiology and epidemiology (by comparing the prevalence of one disease in patients suffering from the other disease), but also experimentally (by studying the sinus involvement following nasal allergen provocations), and pathophysiologically (by phenotyping and comparing the inflammation present in both diseases). Results of such studies are convincing and have confirmed the fundamental role of nasal inflammation in general and allergic inflammation in particular in the genesis of sinusitis (it is now therefore recommended to utilize the term 'rhinosinusitis'). The importance of allergy in the etiologic development of nasal polyps remains controversal and doubtful. Because the diagnosis of allergic rhinitis provides useful therapeutic options, an appropriate evaluation for underlying allergies in indicated in any patient with chronic upper respiratory tract symptoms.
Demoly
P
P
Maladies Respiratoires, INSERM U454, IFR3, Hôpital Arnaud de Villeneuve, Service d'ORL, Hôpital Gui de Chauliac, CHU de Montpellier. demoly@montp.inserm.fr
Bencherioua
A M
AM
Crampette
L
L
Dhivert-Donnadieu
H
H
Godard
P
P
Michel
F B
FB
D003937:Diagnosis, Differential; D016021:Epidemiologic Studies; D006801:Humans; D007249:Inflammation; D009298:Nasal Polyps / Q000209:etiology* / Q000503:physiopathology; D012221:Rhinitis, Allergic, Perennial / Q000150:complications* / Q000503:physiopathology; D012852:Sinusitis / Q000209:etiology* / Q000503:physiopathology