[Antiinflammatory capacity of topical ketorolac in experimental model of ocular inflammation].
OBJECTIVE
We studied the antiinflammatory effect of topical Ketorolac-Tromethamine on a model of endotoxin-induced uveitis in albino rabbits.


METHODS
Endotoxin-induced uveitis was produced by intravitreal injection in the right eye of 10 ng lipopolysaccharide (LPS) A Salmonella typhimurium endotoxin in 5 microl saline solution. We have used 60 animals (5 groups of 12 animals each). Control group (G-I) was injected with saline (5 microl); endotoxin group (G-II) was injected with 10 ng of endotoxin; groups III, IV and V were injected with the same amount of endotoxin and treated with topical ketorolac-tromethamine every 6, 4 and 2 hours respectively. The animals were sacrificed 24 hours after endotoxin administration. We determined the ocular clinical signs and inflammatory cells and protein concentration in the aqueous humor.


RESULTS
In all the groups treated with Ketorolac-Tromethamine we observed a significant reduction (p<0.05) in all parameters studied when compared with those of the endotoxin group (G-II).


CONCLUSIONS
Topical Ketorolac-Tromethamine has demonstrated a significant reduction of endotoxin-induced-uveitis inflammation.
Moreno
O R
OR
Servicio de Oftalmología, Hospital Miguel Servet, Po. Isabel la Católica, 1-3, 50009 Zaragoza, Spain.
Andrés
R C
RC
Júlvez
L P
LP
Llorens
V P
VP
Marín Del Tiempo
D
D
Novella
E F
EF
Torrón
C
C
Honrubia
F M
FM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D020910:Ketorolac / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D014605:Uveitis / Q000188:drug therapy* / Q000209:etiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020910:Ketorolac