Beneficial effects of different flavonoids, on functional recovery after ischemia and reperfusion in isolated rat heart.
Three newly synthesised lipid peroxidation inhibitors (7, 11, 14) were evaluated for their effects on myocardial functional recovery during reperfusion after 30 min global ischemia in isolated rat hearts. The flavonoid compounds (7, 11, 14, rutin) reduce ischemia/reperfusion-induced cardiac dysfunction.
Lebeau
J
J
Equipe Polyphénols, Laboratoire de chimnie organique et macromoléculaire, UPRESA 8009, USTL, Villeneuve d'Ascq, France.
Neviere
R
R
Cotelle
N
N
D000493:Allopurinol / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002599:Chalcone / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D047309:Flavones; D005419:Flavonoids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D009206:Myocardium / Q000201:enzymology / Q000473:pathology*; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy*; D012431:Rutin / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D017725:Ventricular Pressure / Q000187:drug effects
D047309:Flavones; D005419:Flavonoids; D017392:Thiobarbituric Acid Reactive Substances; D012431:Rutin; D002599:Chalcone; D000493:Allopurinol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C043562:flavone