N-Methylsansalvamide, a cytotoxic cyclic depsipeptide from a marine fungus of the genus fusarium.
N-Methylsansalvamide (1), a new cyclic depsipeptide, was isolated from extracts of a cultured marine fungus, strain CNL-619, identified as a member of the genus Fusarium. N-Methylsansalvamide exhibits weak in vitro cytotoxicity in the NCI human tumor cell line screen (GI50 8.3 microM). The structure of 1 was determined by combined spectral and chemical methods.
Cueto
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Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oeanography, University of California, San Diego, La Jolla 92093-0204, USA.
Jensen
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Fenical
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D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014871:Water Microbiology
D000970:Antineoplastic Agents; C419331:N-Methylsansalvamide; D010456:Peptides, Cyclic