title: [Nicorandil-induced giant lingual aphthosis in a patient with Behcet's disease].
abstract: BACKGROUND
  Even in patients with Behçet's disease, disease, the development of severe aphthosis should suggest the possibility of a drug reaction.
  
  
  METHODS
  We observed a case of giant lingual aphthosis that developed four months after adding microrandil to the regimen of a patient with Behçet's disease who had been treated with colchicine for 16 years. The aphthosis healed after withdrawal of nicorandil.
  
  
  CONCLUSIONS
  There have been 21 cases of nicorandil-induced buccal aphthosis reported in the literature. All healed at drug withdrawal. He delay between initiation of treatment of the stomatitis in most patients, the development of the aphthosis after increasing he nicorandil dose in two patients, its regression after reducing the dose in one and pathology date from biopsied cases suggest a dose-dependent toxic mechanism rather than an immunoallergic process is involved. To our knowledge, our case is the first reported with Behçet's disease. In our opinion, nicorandil should not be given to patients with Behçet's disease.
authors.affiliation: Service de Médecine interne, Hôpital Européen Georges Pompidou, 20, rue Leblanc, F 75908 Paris.
authors.forename: C
authors.initials: C
authors.lastname: Haas
authors.forename: F
authors.initials: F
authors.lastname: Dendoune
authors.forename: M
authors.initials: M
authors.lastname: Persoz
authors.forename: C
authors.initials: C
authors.lastname: Le Jeunne
authors.forename: F C
authors.initials: FC
authors.lastname: Hugues
mesh_terms: D000368:Aged; D001528:Behcet Syndrome / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D020108:Nicorandil / Q000008:administration & dosage / Q000009:adverse effects*; D013281:Stomatitis, Aphthous / Q000139:chemically induced*; D014059:Tongue / Q000473:pathology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D020108:Nicorandil