Yersinia lead SUMO attack.
Little is known about the mechanism by which Yops, proteins that Yersinia inject into the cytosol of macrophage, cause downregulation of the inflammatory response and diseases such as the plague. Now it appears that Yops are the first bacterial member of a new family of ubiquitin-like proteases.
Cornelis
G R
GR
Microbial Pathogenesis Unit, Christian de Duve Institute of Cellular Pathology and Faculty of Medicine, Université de Louvain, 74 Av Hippocrate, B1200 Brussels, Belgium. cornelis@mipa.ucl.ac.be
Denecker
G
G
D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology*; D018836:Inflammation Mediators / Q000378:metabolism; D007371:Interferon-gamma / Q000096:biosynthesis; D051379:Mice; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D015007:Yersinia / Q000502:physiology*; D015009:Yersinia Infections / Q000378:metabolism / Q000503:physiopathology*
D001426:Bacterial Proteins; D018836:Inflammation Mediators; D014409:Tumor Necrosis Factor-alpha; C109227:YopP protein, Yersinia; D007371:Interferon-gamma