Self-administration of two long-acting monoamine transport blockers in rhesus monkeys.
BACKGROUND
2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT) is a cocaine analog with high affinity at and selectivity for the dopamine transporter (DAT). 2beta-propanoyl-3beta-(2-naphthyl)-tropane (HD-23), like cocaine, binds with approximately equal affinity to the DAT, the serotonin transporter, and the norepinephrine transporter but has over a 100-fold higher affinity for these monoamine transporters than cocaine. The reinforcing effects of these drugs have not been evaluated in cocaine-na nonhuman primates.


OBJECTIVE
The primary goal of the present study was to examine the reinforcing effects of PTT and HD-23 in rhesus monkeys before and after a history of intravenous cocaine self-administration.


METHODS
Monkeys (n=4) were initially trained to respond under a fixed-ratio 30 schedule of food presentation. When responding was stable, saline, PTT (0.001-0.03 mg/kg per injection), and HD-23 (0.0003-0.0056 mg/kg per injection) were made available for self-administration for least five sessions per dose. Next, a cocaine dose-effect function (0.0003-0.3 mg/kg per injection) was determined and then
Lile
J A
JA
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA.
Morgan
D
D
Freedland
C S
CS
Sinnott
R S
RS
Davies
H M
HM
Nader
M A
MA
D000818:Animals; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D003042:Cocaine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D018492:Dopamine Antagonists / Q000008:administration & dosage*; D050483:Dopamine Plasma Membrane Transport Proteins; D007275:Injections, Intravenous; D008253:Macaca mulatta; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012054:Reinforcement, Psychology; D012646:Self Administration; D014326:Tropanes / Q000008:administration & dosage*
C112780:2-propanoyl-3-(2-naphthyl)-tropane; D002352:Carrier Proteins; D018492:Dopamine Antagonists; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D014326:Tropanes; C114627:WF 11; D003042:Cocaine