[Effect of cycloferon on the evolution of cervical and vaginal cancer  in mice].
7,12-dimethylbenz(a)anthracene (DMBA) was given by tampon intravaginally to 198 mice CBA (9 groups), twice a week, for 2 months, to induce cervical and vaginal tumors. Cycloferon (CF)--an interferon inductor--was injected in study group animals subcutaneously and/or introduced into the vagina by smear, in 2-month courses. CF was given during DMBA treatment or after it. Controls were injected saline solution, sc, and/or received placebo smears, i.v. The experiment was run for 6 months. Tumor incidence in controls was 35-70%. Carcinogenesis tended to slow down when CF was given during DMBA treatment. Neoplasia was found in 38-57%. More marked anticarcinogenic effect was registered in animals receiving CF on termination of DMBA application: tumor frequency dropped to 29-41%, with malignant tumor number significantly reduced.
Zabezhinskiĭ
M A
MA
N.N. Petrov Research Institute of Oncology, the Ministry of Health of the RF, St. Petersburg.
Zarinova
E A
EA
Popovich
I G
IG
Kovalenko
A L
AL
Anisimov
V N
VN
D015127:9,10-Dimethyl-1,2-benzanthracene; D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D007369:Interferon Inducers / Q000494:pharmacology*; D051379:Mice; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D014625:Vaginal Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
D000166:Acridines; D016588:Anticarcinogenic Agents; D007369:Interferon Inducers; D015127:9,10-Dimethyl-1,2-benzanthracene; C026430:10-carboxymethyl-9-acridanone