title: Minimizing blood loss in burn surgery.
abstract: BACKGROUND
  Significant blood loss continues to plague early tangential excision of the burn wound. Although various techniques to reduce intraoperative blood loss have been described, there is an absence of uniformity and consistency in their application. Furthermore, it is unclear whether these techniques compromise intraoperative tissue assessment and wound outcome. The purpose of this study was to evaluate the effects of a comprehensive intraoperative blood conservation strategy on blood loss, transfusion requirements, and wound outcome in burn surgery.
  
  
  METHODS
  An intraoperative blood conservation strategy (CONSV) that included donor site and burn wound adrenaline tumescence, donor site and excised wound topical adrenaline, and limb tourniquets was prospectively evaluated and compared with a historical control group (HIST) where only topical adrenaline and thrombin were applied to donor sites and excised wounds.
  
  
  RESULTS
  Estimated blood loss was reduced from 211 +/- 166 mL per percentage body surface area excised and grafted in the HIST group to 123 +/- 106 mL in the CONSV group (p = 0.02). Similarly, the intraoperative transfusion requirement in the HIST group was reduced from 3.3 +/- 3.1 units per case to 0.1 +/- 0.3 units per case in the CONSV group (p < 0.001). There was no compromise in wound outcome in the CONSV group, which had a mean skin graft take rate of 96 +/- 4.2%.
  
  
  CONCLUSIONS
  The application of a strict and comprehensive intraoperative blood conservation strategy during burn excision and grafting resulted in a profound reduction in blood loss and transfusion requirements, without compromising wound outcome.
authors.affiliation: Ross Tilley Burn Center, Department of Surgery, Toronto, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Cartotto
authors.forename: M A
authors.initials: MA
authors.lastname: Musgrave
authors.forename: M
authors.initials: M
authors.lastname: Beveridge
authors.forename: J
authors.initials: J
authors.lastname: Fish
authors.forename: M
authors.initials: M
authors.lastname: Gomez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002056:Burns / Q000601:surgery*; D016022:Case-Control Studies; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D016038:Skin Transplantation; D016896:Treatment Outcome