The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants.
Here we show that the rate of poleward chromosome motion in zw10-null mutants is greatly attenuated throughout the division process, and that chromosome disjunction at anaphase is highly asynchronous. Our results show that ZW10 protein, together with Rod, is involved in production and/or regulation of the force responsible for poleward chromosome motion.
Savoian
M S
MS
Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, New York 12201-0509, USA.
Goldberg
M L
ML
Rieder
C L
CL
D000818:Animals; D018797:Cell Cycle Proteins; D002875:Chromosomes / Q000502:physiology*; D004330:Drosophila / Q000166:cytology / Q000235:genetics* / Q000502:physiology*; D029721:Drosophila Proteins; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics* / Q000502:physiology*; D008297:Male; D008540:Meiosis / Q000235:genetics / Q000502:physiology; D018715:Microscopy, Video; D020409:Molecular Motor Proteins / Q000235:genetics / Q000502:physiology; D009068:Movement / Q000502:physiology; D009154:Mutation; D013090:Spermatocytes / Q000166:cytology / Q000502:physiology
D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D020409:Molecular Motor Proteins; C076055:Zw10 protein, Drosophila