title: Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children.
abstract: In a randomized, double-blind controlled trial, 42 children with irritable bowel syndrome (IBS) were given pH-dependent, enteric-coated peppermint oil capsules or placebo. After 2 weeks, 75% of those receiving peppermint oil had reduced severity of pain associated with IBS. Peppermint oil may be used as a therapeutic agent during the symptomatic phase of IBS.
authors.affiliation: University of Missouri-Columbia, Department of Child Health, Division of Pediatric Gastroenterology, Columbia, Missouri, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Kline
authors.forename: J J
authors.initials: JJ
authors.lastname: Kline
authors.lastname: Di Palma J
authors.forename: G J
authors.initials: GJ
authors.lastname: Barbero
mesh_terms: D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology; D000293:Adolescent; D000367:Age Factors; D002648:Child; D003109:Colonic Diseases, Functional / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D036142:Mentha piperita; D010147:Pain Measurement; D010276:Parasympatholytics / Q000627:therapeutic use*; D010938:Plant Oils / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013608:Tablets, Enteric-Coated / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010276:Parasympatholytics; D010938:Plant Oils; D013608:Tablets, Enteric-Coated; C015424:peppermint oil