Early myocardial infarction during chemotherapy for testicular cancer.
A 36-year-old man with testicular cancer had an acute myocardial infarction during the first course of chemotherapy with bleomycin, etoposide and cisplatin. Since the patient had no significant risk factors for coronary heart disease, the infarction was likely to be attributable to the chemotherapy regimen. The physiopathological mechanisms of this causal relationship are discussed here.
Bachmeyer
C
C
Department of Internal Medicine, H pital Laénnec, Creil, France.
Joly
H
H
Jorest
R
R
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001761:Bleomycin / Q000009:adverse effects; D018236:Carcinoma, Embryonal / Q000188:drug therapy; D002945:Cisplatin / Q000009:adverse effects; D004562:Electrocardiography / Q000187:drug effects; D005047:Etoposide / Q000009:adverse effects; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis / Q000201:enzymology / Q000503:physiopathology; D013724:Teratoma / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy*
D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin