Cross-coupling of highly pyramidalized alkenes: A straightforward access to functionalized tetrasecododecahedradienes
The synthesis and chemical trapping of a highly pyramidalized pentacyclo[6.4.0.0(2,10).0(3,7).0(4,9)]dodec-8-ene containing ketal functions is reported. Its cross-coupling reaction with 3, 7-dimethyltricyclo[3.3.0.0(3,7)]oct-1(5)-ene followed by a [2 + 2] retrocycloaddition reaction gives a straightforward access to functionalized tetrasecododecahedradienes.
Camps
P
Laboratori de Quimica Farmaceutica, Facultat de Farmacia, Universitat de Barcelona, Av. Diagonal 643, Barcelona, E-08028, Spain.
Pujol
X
Vazquez
S