Uncovering the differences between T cell tolerance and immunity.
In the last two decades, T cell function has been analyzed in vitro from many different angles, with a great deal of attention dedicated to the basic requirements of activation. During this time, a compendium of information has been collected and has proven to be invaluable. Paradoxically, very little is known about T cell activation and function in vivo. In the last decade, a number of models have been developed which allow the tracking of Ag-activated T cells in vivo and these studies have been instrumental in advancing the field of T cell biology. In particular, a new and emerging paradigm of T cell immunity is evolving.
Vella
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Department of Microbiology, Oregon State University, Corvallis 97331, USA. vellaa@bcc.orst.edu
D002470:Cell Survival; D016207:Cytokines; D007108:Immune Tolerance; D007109:Immunity; D007156:Immunologic Memory; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines