Keratographic analysis of a family with keratoconus in identical twins.
We screened family members of monozygotic twins with keratoconus to search for a corneal thinning disorder using clinical, videokeratographic, and pachymetric analyses. The parents had bilateral astigmatism of a symmetric bow-tie pattern with normal videokeratographic and pachymetric indices. The 8-year-old sister had slightly asymmetric astigmatism in both eyes with normal pachymetry values. No family member was suspected of a corneal thinning disorder. We discuss the mode of inheritance of keratoconus in this family.
Schmitt-Bernard
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Department of Ophthalmology, CHU Montpellier, Montpellier, France. cfsb@mail.mnet.fr
Schneider
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Blanc
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Arnaud
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B
D000293:Adolescent; D003315:Cornea / Q000473:pathology* / Q000601:surgery; D019781:Corneal Topography; D016039:Corneal Transplantation; D003937:Diagnosis, Differential; D004200:Diseases in Twins / Q000175:diagnosis; D006801:Humans; D007640:Keratoconus / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D008297:Male; D009679:Nuclear Family; D014430:Twins, Monozygotic; D014792:Visual Acuity