title: [Local cyclosporin A in nummuli after keratoconjunctivitis epidemica. A pilot study].
abstract: BACKGROUND
  Recurrences are common after discontinuing topical steroids against nummular infiltrates following adenoviral keratoconjunctivitis (AK). To avoid the potentially serious side effects of resumed steroid treatment at increased doses we tested topical 2% cyclosporin A (CSA).
  
  
  METHODS
  We applied four drops of CSA daily to 70 eyes (48 patients) with persistent nummular infiltrates after AK. Treatment began 18.5 months (3-72) after the acute phase of AK. Dose reduction depended on resolution of the nummuli in the individual patients.
  
  
  RESULTS
  Of the 70 eyes 40 responded positively to therapy, 16 showed no change, therapy was stopped in 4 because of ocular discomfort (burning), and in 10 eyes follow-up is still less than 3 months.
  
  
  CONCLUSIONS
  CSA was effective in eliminating or reducing nummuli in the majority of patients. More than one-half of the responding eyes had a complete cure and did not experience recurrences after stopping therapy. We therefore consider topical CSA to be a safe and effective alternative to topical steroids for treating nummular infiltrates after AK.
authors.affiliation: Augenklinik der Heinrich-Heine-Universität, Moorenstrasse 5, 40225 Düsseldorf. reinhath@uni-duesseldorf.de
authors.forename: T
authors.initials: T
authors.lastname: Reinhard
authors.forename: E
authors.initials: E
authors.lastname: Godehardt
authors.forename: H G
authors.initials: HG
authors.lastname: Pfahl
authors.forename: R
authors.initials: R
authors.lastname: Sundmacher
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003236:Conjunctivitis, Viral / Q000175:diagnosis / Q000188:drug therapy*; D003318:Corneal Opacity / Q000175:diagnosis / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007637:Keratoconjunctivitis / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D016896:Treatment Outcome
chemical_list: D009883:Ophthalmic Solutions; D016572:Cyclosporine