Discharge frequencies of single motor units in human diaphragm and parasternal muscles in lying and standing.
Single motor unit discharge was measured directly in diaphragm and parasternal intercostal muscles to determine whether neural drive to human inspiratory muscles changes between lying and standing. The final discharge frequency of diaphragmatic motor units increased slightly, by 1 Hz (12%; P < 0.01), when subjects were standing [182 units, median 9.1 Hz (interquartile range 7.6-11.3 Hz)] compared with lying supine [159 units, 8.1 Hz (6.6-10.3 Hz)]. However, this increase with standing occurred in only two of six subjects, in one of whom tidal volume increased significantly during standing. Parasternal intercostal motor unit final discharge frequencies did not differ between standing [116 units, 8.0 Hz (6.6-9.6 Hz)] and lying [124 units, 8.4 Hz (7.0-10.3 Hz)]. The discharge frequencies at the onset of inspiration did not differ between lying and standing for either muscle. A larger proportion of motor units in both inspiratory muscles had postinspiratory or tonic expiratory activity for lying compared with standing (15 vs. 4%; P < 0.05). We conclude that there is no major difference in the phasic inspiratory drive to the diaphragm with the change in posture.
Butler
J E
JE
Prince of Wales Medical Research Institute, and University of New South Wales, Sydney, New South Wales 2031, Australia.
McKenzie
D K
DK
Gandevia
S C
SC
D003964:Diaphragm / Q000294:innervation*; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000502:physiology*; D011187:Posture / Q000502:physiology*; D012132:Respiratory Muscles / Q000294:innervation*; D012143:Respiratory Physiological Phenomena; D013249:Sternum; D016683:Supine Position / Q000502:physiology*