Synthesis of (3alpha,7beta,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer.
The syntheses of the 7beta-hydroxy metabolite of ORG OD14 (Livial((R))), (3alpha,7beta,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol (35), and its 7-epimer, (3alpha,7alpha,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol (11), are described.
Plate
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Medicinal Chemistry Department, N.V. Organon, P.O. Box 20, 5340, BH Oss, The Netherlands. R.Plate@organon.oss.akzonobel.nl
van Wuijtswinkel
R C
RC
Jans
C G
CG
Groen
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MB
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009652:Norpregnenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
D009652:Norpregnenes; C027385:tibolone