The role of quorum sensing in the in vivo virulence of Pseudomonas aeruginosa.
Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide variety of infections. The cell-density-dependent signaling mechanisms known as quorum sensing play a role in several of these infections including corneal, lung and burn wound infections. In addition, the quorum-sensing systems contribute to the ability of P. aeruginosa to form biofilms on medically important devices. The quorum-sensing systems accomplish their effect by controlling the production of different virulence factors and by manipulating the host immune response.
Rumbaugh
K P
KP
Department of Microbiology and Immunology, Texas Tech. University Health Sciences Center, 3601 4th St., Lubbock, Texas, 79430, USA.
Griswold
J A
JA
Hamood
A N
AN
D000818:Animals; D002056:Burns / Q000382:microbiology; D002452:Cell Count; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*; D015398:Signal Transduction