title: [Relationship between interleukin-2, interleukin-2 receptor and the non-and hypo-responsiveness to hepatitis B vaccine].
abstract: OBJECTIVE
  To study the relationship between interleukin-2 (IL-2), soluble interleukin-2 receptor (sIL-2R) and the non-and-hypo-responsiveness to hepatitis B vaccine.
  
  
  METHODS
  Peripheral blood mononuclear cells (PBMC) isolated from 21 non-and -hypo-responders, 22 hyperresponders and 21 chronic HBsAg carriers were incubated in the presence of HBsAg and phytohaemagglutinin (PHA). The levels of IL-2 and sIL-2R in the supernatants of activated cells were measured by an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The average level of IL-2 in the non-and-hypo-responders was significantly lower than that in the hyperresponders (t=8.80, P<0.001), but was comparable to that in chronic HBsAg carriers (q=0.06, P>0.5). Between the hyperresponders and the non-and-hypo-responders, the average sIL-2R levels showed no noticeable difference.
  
  
  CONCLUSIONS
  The results suggest that low level of IL-2 may be one of the causes and mechanisms of non-and-hypo-responsiveness to hepatitis B vaccine.
authors.affiliation: Department of Epidemiology Xi'an Medical University, Xi'an 710061, China.
authors.forename: J
authors.initials: J
authors.lastname: Xie
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Zhuang
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: B
authors.initials: B
authors.lastname: Hao
authors.forename: X
authors.initials: X
authors.lastname: Tang
authors.forename: Q
authors.initials: Q
authors.lastname: Wu
mesh_terms: D002353:Carrier State / Q000276:immunology; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D015375:Receptors, Interleukin-2 / Q000097:blood*
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D007376:Interleukin-2; D015375:Receptors, Interleukin-2