Prolactin levels and autoantibodies in female patients with systemic lupus erythematosus.
We investigated the relationships between prolactin (PRL) levels and antibody occurrence in systemic lupus erythematosus (SLE). No significant association between PRL levels and the majority of the autoantibodies studied (anti-U1 RNP, anti-rRNP, anti-Sm, anti-dsDNA, anti-DNP, auto-LCA, anti-EACA) could be confirmed (P > 0.05), anti-Ro/SSA antibodies being an exception. Our results showed significantly increased frequencies of these antibodies in the group of female SLE patients with normal PRL levels (< 20 micrograms/L): anti Ro/SSA in 53% (P < 0.025, chi 2 = 5.80, RR = 4.0) and anti-Ro/SSA + anti-Ro/La in 60% (P < 0.05, chi 2 = 4.05) compared with female SLE patients with hyperprolactinemia.
Kozáková
D
D
Research Institute of Rheumatic Diseases, Nábrezie I. Krasku 92101 Piestăny, Slovak Republic.
Rovenský
J
J
Cebecauer
L
L
Bosák
V
V
Jahnová
E
E
Vigas
M
M
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D012016:Reference Values
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C035356:SS-A antibodies; D011388:Prolactin