Proton magnetic resonance spectroscopy and morphometry of the hippocampus in chronic fatigue syndrome.
Seven patients with chronic fatigue syndrome (CFS) were matched with ten healthy control subjects of similar age. Hippocampal volume, obtained from magnetic resonance images using an unbiased method, showed no difference between the two groups, whereas proton magnetic resonance spectroscopy showed a significantly reduced concentration of N-acetylaspartate in the right hippocampus of CFS patients (p = 0.005).
Brooks
J C
JC
Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Pembroke Place, Liverpool L69 3BX, UK.
Roberts
N
N
Whitehouse
G
G
Majeed
T
T
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D015673:Fatigue Syndrome, Chronic / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male
D001224:Aspartic Acid; C000179:N-acetylaspartate