The chemistry of enamel caries.
The chemical changes which occur during the process of carious destruction of enamel are complex due to a number of factors. First, substituted hydroxyapatite, the main component of dental enamel, can behave in a very complex manner during dissolution. This is due not only to its ability to accept substituent ions but also to the wide range of calcium phosphate species which can form following dissolution. In addition, the composition, i.e., the extent of substitution, changes throughout enamel in the direction of carious attack, i.e., from surface to interior. Both surface and positively birefringent zones of the lesion clearly illustrate that carious destruction is not simple dissolution. Selective dissolution of soluble minerals occurs, and there is the probability of reprecipitation. The role of fluoride here is crucial in that not only does it protect enamel per se but also its presence in solution means that rather insoluble fluoridated species can form very easily, encouraging redeposition. The role of organic material clearly needs further investigation, but there is the real possibility of both inhibition of repair and facilitation of redeposition. For the future, delivering fluoride deep into the lesion would appear to offer the prospect of improved repair. This would entail a delivery vehicle which solved the problem of fluoride uptake by apatite at the tooth surface. Elucidation of the role of organic material may also reveal putative mechanisms for encouraging repair and/or protecting the enamel mineral.
Robinson
C
C
University of Leeds, Leeds Dental Institute, Division of Oral Biology, United Kingdom. orl6cr@oralbio.novell.Leeds.ac.uk
Shore
R C
RC
Brookes
S J
SJ
Strafford
S
S
Wood
S R
SR
Kirkham
J
J
D000818:Animals; D003731:Dental Caries / Q000378:metabolism*; D003743:Dental Enamel / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D003745:Dental Enamel Permeability; D003747:Dental Enamel Solubility; D017886:Durapatite / Q000378:metabolism; D005459:Fluorides / Q000493:pharmacokinetics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008903:Minerals / Q000378:metabolism; D015394:Molecular Structure
D008903:Minerals; D017886:Durapatite; D005459:Fluorides