Dual effects of four members of the fibroblast growth factor member family on multiplication and motility in human teratocarcinoma cells in vitro.
The effects of four recently discovered members of the Fibroblast Growth Factor family, FGF-10, FGF-16, FGF-17 and FGF-18, on the human embryonal carcinoma derived cell line Tera 2 were examined. It was found that all four FGF:s enhanced the survival rate of Tera-2 cells by counteracting apoptosis at concentrations in the interval 1-10 ng/ml. When higher concentrations of either of the four FGF:s were added, a preferential effect on cell motility was observed. The observed requirements for externally supplied FGF:s were complemented by the expression of all four FGF-receptors.
Granerus
M
M
Department of Pathology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, S-750 07 Uppsala, Sweden.
Engström
W
W
D015152:Blotting, Northern; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D051526:Fibroblast Growth Factor 10; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D006801:Humans; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D017468:Receptors, Fibroblast Growth Factor / Q000096:biosynthesis / Q000235:genetics; D011994:Recombinant Proteins / Q000494:pharmacology; D018243:Teratocarcinoma / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
C496463:FGF10 protein, human; C484724:FGF17 protein, human; C110776:Fgf16 protein, rat; D051526:Fibroblast Growth Factor 10; D012333:RNA, Messenger; D017468:Receptors, Fibroblast Growth Factor; D011994:Recombinant Proteins; C113569:fibroblast growth factor 18; D005346:Fibroblast Growth Factors