Adeno-associated virus in normal and myositis human skeletal muscle.
The normal tissue tropism of adeno-associated virus (AAV) is poorly defined, although the majority of humans test seropositive for this virus. Eighty-five muscle biopsy specimens were tested for AAV genomes; AAV DNA was identified in 17% of normal and 10% of Duchenne muscular dystrophy muscle biopsy specimens, but in only 3% of peripheral blood samples. AAV genomes were absent from all 37 muscle biopsy specimens from patients with myositis tested. Muscle is a major target organ for AAV, and infection is associated with autoimmune disease of muscle.
Tezak
Z
Z
Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA.
Nagaraju
K
K
Plotz
P
P
Hoffman
E P
EP
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D000229:Dependovirus / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009220:Myositis / Q000235:genetics* / Q000473:pathology*; D016133:Polymerase Chain Reaction; D014771:Virion / Q000235:genetics