[The modulators of the estrogenic activity].
The biological, pharmacological and therapeutic properties of estrogens/antiestrogens are related to their chemical structure. Tamoxifen, used for the treatment of hormone-dependent breast cancer, and other analogue derivatives of triarylethylene or presenting a cyclic or heterocyclic structure, mimic some of the activities of estrogens. They have major therapeutic potential as selective estrogen receptor modulators in the prevention of breast cancer and various post-menopausal conditions.
Kirkiacharian
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Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de Paris-Sud 5, rue Jean-Baptiste Clément F 92296 Chatenay-Malabary Cedex.
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D045166:Estradiol Congeners / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D020847:Estrogen Receptor Modulators / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017698:Postmenopause; D011960:Receptors, Estrogen / Q000187:drug effects*
D045166:Estradiol Congeners; D020847:Estrogen Receptor Modulators; D004967:Estrogens; D011960:Receptors, Estrogen