Synthesis and biological activity of BIS-1,2,4-triazole and BIS-1,3,4-thiadiazole derivatives.
Synthesis of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives via the condensation of N'-substituted amidrazones and p-phenylenediisothiocyanate (PPD) is presented. The reaction conditions are discussed. Results of a preliminary pharmacological screening are presented.
Modzelewska-Banachiewicz
B
B
Department of Organic Chemistry, Faculty of Pharmacy, Medicine University, 6 Staszica Str., 20-081 Lublin, Poland.
Jagiełło-Wójtowicz
E
E
Tokarzewska-Wielosz
E
E
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D013844:Thiazoles; D014230:Triazoles