Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy.
We report on the association study of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy. A single-nucleotide polymorphism in TNFR2, which is involved in an amino acid substitution [methionine(M)/arginine(R)] at position 196, was investigated in 149 Japanese narcoleptic patients and 204 healthy individuals as controls. Results reveal that the frequency of the TNFR2-196R allele significantly increased in the patients as compared with that in the controls (P=0.029), suggesting that TNFR2 is likely associated with the susceptibility to narcolepsy. In addition, the analyses of the relationship of TNFR2 and TNF-alpha with the susceptibility to narcolepsy indicate the possibility that an additive effect on the susceptibility to the disorder lies between TNFR2-196R and TNF-alpha(-857T) alleles.
Hohjoh
H
H
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan. hohjohh@m.u-tokyo.ac.jp
Terada
N
N
Kawashima
M
M
Honda
Y
Y
Tokunaga
K
K
D019943:Amino Acid Substitution; D015703:Antigens, CD / Q000235:genetics*; D001120:Arginine / Q000235:genetics; D006801:Humans; D008715:Methionine / Q000235:genetics; D009290:Narcolepsy / Q000235:genetics* / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*; D047889:Receptors, Tumor Necrosis Factor, Type II
D015703:Antigens, CD; D018124:Receptors, Tumor Necrosis Factor; D047889:Receptors, Tumor Necrosis Factor, Type II; D001120:Arginine; D008715:Methionine