title: HTLV-1-associated myelopathy/tropical spastic paraparesis with pseudohypoparathyroidism.
abstract: In many short-stature patients with human T-lymphotrophic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), signs and symptoms were manifested during childhood. Successive investigations revealed 12 of 14 short-stature patients with pseudohypoparathyroidism (PHP) from the findings of short metacarpi, parathyroid hormone infusion test, immunoblotting of erythrocyte membrane, or lymphocytic Northern blotting of Gsalpha. Patients with PHP probably showed HAM/TSP based on their modified immunologic status. Human T-lymphotrophic virus type I infection did not induce PHP, but PHP may be a risk factor for the occurrence of HAM/TSP.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Machigashira
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001827:Body Height; D004910:Erythrocyte Membrane / Q000737:chemistry; D005260:Female; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology*; D011547:Pseudohypoparathyroidism / Q000453:epidemiology*; D012307:Risk Factors
chemical_list: D019205:GTP-Binding Protein alpha Subunits, Gs