Selective cancer cell killing by alpha-tocopheryl succinate.
We report that alpha-tocopheryl succinate, a vitamin E analogue with pro-apoptotic properties, selectively kills cells with a malignant or transformed phenotype, i.e. multiple haematopoietic and carcinoma cell lines, while being non-toxic to normal, i.e. primary and non-transformed cells. These findings strongly suggest a potential of this micronutrient in the therapy and/or prevention of cancer without significant side-effects.
Neuzil
J
J
Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Pettenkoferstrasse 9, Munich, 80336, Germany.
Weber
T
T
Gellert
N
N
Weber
C
C
D017209:Apoptosis; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D024505:Tocopherols; D014407:Tumor Cells, Cultured / Q000187:drug effects*; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014810:Vitamin E; D024505:Tocopherols