deltaFosB: a molecular switch underlying long-term neural plasticity.
Numerous chronic perturbations have been shown to induce highly stable isoforms of the transcription factor deltaFosB in the brain in a region-specific manner. This review examines the functional consequences of the induction of deltaFosB in particular neuronal populations as well as its possible role in behavioral abnormalities such as drug addiction and movement disorders.
Kelz
M B
MB
Department of Anesthesiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Nestler
E J
EJ
D000818:Animals; D006801:Humans; D009069:Movement Disorders / Q000235:genetics; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*; D019966:Substance-Related Disorders / Q000235:genetics; D018808:Transcription Factor AP-1 / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
D018808:Transcription Factor AP-1; D014157:Transcription Factors