title: Enantioselective addition of 2-methyl-3-butyn-2-ol to aldehydes: preparation of 3-hydroxy-1-butynes
abstract: We report the first example of enantioselective aldehyde additions of 2-methyl-3-butyn-2-ol, a commodity bulk chemical that is readily available. Following a facile fragmentation reaction, the addition reactions provide access to optically active terminal acetylenes as useful building blocks for asymmetric synthesis.
authors.affiliation: Laboratorium fur Organische Chemie, ETH-Zentrum, Universitatstrasse 16, CH-8092 Zurich, Switzerland.
authors.initials: D
authors.lastname: Boyall
authors.initials: F
authors.lastname: Lopez
authors.initials: H
authors.lastname: Sasaki
authors.initials: D
authors.lastname: Frantz
authors.initials: EM
authors.lastname: Carreira