title: Hepatitis C virus and interferon resistance.
abstract: Interferon plays a critical role in the host's natural defense against viral infections and in their treatment. It is the only therapy for hepatitis C virus (HCV) infection; however, many virus isolates are resistant. Several HCV proteins have been shown to possess properties that enable the virus to evade the interferon-mediated cellular antiviral responses.
authors.affiliation: Department of Molecular Microbiology and Immunology, University of Southern California, School of Medicine, 2011 Zonal Avenue, Los Angeles, CA 90089, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Taylor
authors.forename: S T
authors.initials: ST
authors.lastname: Shi
authors.forename: M M
authors.initials: MM
authors.lastname: Lai
mesh_terms: D000818:Animals; D014644:Genetic Variation; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000276:immunology; D006801:Humans; D007372:Interferons / Q000502:physiology*; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D014764:Viral Proteins; D007372:Interferons