title: Determination of a redox compensation index and its relationships to glycaemic control in type 2 diabetes mellitus.
abstract: The measurement of single parameters of oxidative stress in biological fluids can often give results difficult to interpret as to the real involvement of oxidative processes in a given disease condition. In the present study we propose a novel integrated parameter, called "redox compensation index", obtained by combining the results of two established and convenient procedures, i.e. the Fox-2 assay for plasma lipid hydroperoxides and the ferric reducing/antioxidant power (FRAP) assay for total antioxidant potential of plasma. These procedures were employed for the evaluation of oxidative stress in a group of patients with type 2 diabetes mellitus, a condition in which oxidative processes are implicated in the development of complications. In type 2 diabetic patients, plasma lipid hydroperoxides were directly correlated with levels of glycated hemoglobin. On the other hand, a significant inverse correlation was observed between levels of glycated hemoglobin and redox compensation values. The data reported suggest that the redox compensation index could represent a convenient parameter for the direct appraisal of oxidative status in clinical subjects, and are in support of the proposed role of protein glycation in production of oxidative alterations during type 2 diabetes mellitus.
authors.affiliation: Department of Pathophysiology and Experimental Medicine, University of Siena, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Sugherini
authors.forename: M
authors.initials: M
authors.lastname: Valentini
authors.forename: C
authors.initials: C
authors.lastname: Cambiaggi
authors.forename: I
authors.initials: I
authors.lastname: Tanganelli
authors.forename: G
authors.initials: G
authors.lastname: Gragnoli
authors.forename: P
authors.initials: P
authors.lastname: Borgogni
authors.forename: M
authors.initials: M
authors.lastname: Comporti
authors.forename: A
authors.initials: A
authors.lastname: Pompella
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction
chemical_list: D001786:Blood Glucose; D008054:Lipid Peroxides