Endothelial activation--a strategic event during postischemic myocardial inflammation.
Reperfusion after limited ischemia increases leukocyte adhesion, which may contribute to postischemic myocardial and endothelial stunning. Leukocyte adhesion is enhanced immediately after the onset of reperfusion, indicating rapid regulatory mechanisms. In addition, de novo synthesis of, e.g., adhesion molecules induced by reperfusion has been described, providing a prolonged postischemic inflammatory reaction. Enhanced transcription of adhesion molecules involves NF kappa B activation which appears as an essential transcription factor for reperfusion-induced subacute endothelial activation. Both, acute and subacute endothelial activation seem to contribute to the final extent of leukocyte-dependent reperfusion injury and successive treatment of both appears to be a promising therapeutic strategy for postischemic myocardial inflammation and its detrimental effects.
Kupatt
C
C
Internal Medicine I, University Klinikum Grosshadern, Marchioninistr. 15, 81377 Munich, Germany. c.kupatt@lrz.uni-muenchen.de
Habazettl
H
H
Becker
B F
BF
Boekstegers
P
P
D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology; D002478:Cells, Cultured; D004285:Dogs; D004730:Endothelium, Vascular / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000502:physiology; D007962:Leukocytes / Q000502:physiology; D015425:Myocardial Reperfusion; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D017682:Myocardial Stunning / Q000503:physiopathology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017382:Reactive Oxygen Species; D019087:Selectins / Q000235:genetics / Q000502:physiology; D013997:Time Factors; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D015854:Up-Regulation
D015815:Cell Adhesion Molecules; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D019087:Selectins; D014157:Transcription Factors; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1