title: Cytotoxic cembrenolides and steroids from the formosan soft coral Sarcophyton crassocaule.
abstract: Three new cytotoxic cembrenolide diterpenes, sarcocrassolide (1), crassolide (2), and 13-acetoxysarcocrassolide (3); a known cytotoxic cembrenolide, denticulatolide (4); and two cytotoxic steroids, (24S)-24-methylcholestane-3beta,5alpha,6beta-triol (5) and 24zeta-methylcholestane-3beta,5alpha,6beta,25-te traol-25-monoacetate (6), have been isolated from the Formosan soft coral Sarcophyton crassocaule. The structures of compounds 1-6 were determined by 1D and 2D spectral analysis.
authors.affiliation: Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
authors.forename: C Y
authors.initials: CY
authors.lastname: Duh
authors.forename: S K
authors.initials: SK
authors.lastname: Wang
authors.forename: S G
authors.initials: SG
authors.lastname: Chung
authors.forename: G C
authors.initials: GC
authors.lastname: Chou
authors.forename: C F
authors.initials: CF
authors.lastname: Dai
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: C421030:24-methylcholestane-3,5,6,25-tetraol-25-monoacetate; C421029:24-methylcholestane-3,5,6-triol; D000970:Antineoplastic Agents; D004224:Diterpenes