The value of genotyping for apolipoprotein E alleles in relation to vitamin E supplementation.
The clinical utility of genotyping individuals for apolipoprotein E alleles remains controversial. The present summary reviews clinical and scientific data that suggest that vitamin E supplementation may be beneficial in individuals who carry the apolipoprotein E4 allele. We propose that early anti-oxidant intervention with vitamin E supplementation may have life-long beneficial effects for individuals who carry one or more apolipoprotein E4 alleles.
Peroutka
S J
SJ
Dreon
D M
DM
D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D003327:Coronary Disease / Q000473:pathology / Q000517:prevention & control; D005838:Genotype; D006801:Humans; D009410:Nerve Degeneration / Q000473:pathology / Q000517:prevention & control; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use
D001057:Apolipoproteins E; D014810:Vitamin E