title: Moderate hypothermia improves imbalances of thromboxane A2 and prostaglandin I2 production after traumatic brain injury in humans.
abstract: OBJECTIVE
  To examine the levels of thromboxane B2 (TXB2) and 6-keto prostaglandin F1alpha (6-keto PGF1alpha) production in arterial and internal jugular bulb sera in patients with traumatic brain injury (TBI). TBI is associated with arachidonate release and may be associated with an imbalance of vasoconstricting and vasodilating cyclooxygenase metabolites.
  
  
  METHODS
  A prospective, randomized study.
  
  
  METHODS
  The intensive care unit of a medical university hospital.
  
  
  METHODS
  Twenty-six ventilated TBI patents (Glasgow Coma Scale score on admission, < or = 8 points) were divided randomly into two groups: a hypothermic group (n = 15), in which the patients were cooled to 32 to 33 degrees C after being giving vecuronium, midazolam, and buprenorphine; and a normothermic group (n = 11), in which the patients' body temperature was controlled at 36 to 37 degrees C by surface cooling using the same treatment as the hypothermic group. Body temperature control including normothermia was started 3 to 4 hrs after injury. The duration of hypothermia usually lasted for 3 to 4 days, after which the patients were rewarmed at a rate of approximately 1 C per day.
  
  
  RESULTS
  Blood sampling for TXB2 and 6-keto PGF1alpha was started shortly after admission in both groups. Arterial TXB2 levels on admission in both groups were elevated remarkably, but not 6-keto PGF1alpha, thereby causing an imbalance of the prostanoids after injury. In the normothermic group, TXB2 decreased transiently, but this prostanoid increased again 3 days after the injury. In the hypothermic group, such prostanoid differences disappeared shortly after therapy, and the condition was sustained for 10 days. Hypothermia attenuated differences in TXB2 levels between arterial and internal jugular bulb sera, which may reflect reduced cerebral prostanoid production. The Glasgow Outcome Scale score 6 months after the insult in the hypothermic group was significantly higher than that in the normothermic group (p = .04).
  
  
  CONCLUSIONS
  The current results from a limited number of patients suggest that moderate hypothermia may reduce prostanoid production after TBI, thereby attenuating an imbalance of thromboxane A2 and prostaglandin I2. However, it must be clarified whether the changes in the prostanoid after moderate hypothermia are a secondary effect of other mediator changes or whether they simply represent an epiphenomenon that is mechanistically unrelated to damage in TBI.
authors.affiliation: Intensive Care Unit, Kagawa Medical University Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Aibiki
authors.forename: S
authors.initials: S
authors.lastname: Maekawa
authors.forename: S
authors.initials: S
authors.lastname: Yokono
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000627:therapeutic use; D016718:Arachidonic Acid / Q000378:metabolism; D001930:Brain Injuries / Q000378:metabolism* / Q000628:therapy*; D002047:Buprenorphine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007036:Hypothermia, Induced / Q000379:methods*; D007601:Jugular Veins; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use; D011446:Prospective Studies; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013928:Thromboxane A2 / Q000097:blood*; D013997:Time Factors; D016896:Treatment Outcome; D014673:Vecuronium Bromide / Q000627:therapeutic use
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D003473:Neuromuscular Nondepolarizing Agents; D016718:Arachidonic Acid; D002047:Buprenorphine; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D014673:Vecuronium Bromide; D011451:Prostaglandin-Endoperoxide Synthases; D008874:Midazolam