[D-Leu1]Microcystin-LR, from the cyanobacterium Microcystis RST 9501 and from a Microcystis bloom in the Patos Lagoon estuary, Brazil.
[D-Leu1]Microcystin-LR was identified as the most abundant microcystin from a laboratory strain of the cyanobacterium Microcystis sp. isolated from a hepatotoxic Microcystis bloom from brackish waters in the Patos Lagoon estuary, southern Brazil. Toxicity of [D-Leu1]microcystin-LR, according to bioassay and protein phosphatase inhibition assay, was similar to that of the commonly-occurring microcystin-LR, which was not detectable in the Patos Lagoon laboratory isolate. This is the first report of a microcystin containing [D-Leu1] in the cyclic heptapeptide structure of these potent cyanobacterial toxins.
Matthiensen
A
A
Department of Biological Sciences, University of Dundee, UK.
Beattie
K A
KA
Yunes
J S
JS
Kaya
K
K
Codd
G A
GA
D001938:Brazil; D009682:Magnetic Resonance Spectroscopy; D052998:Microcystins; D046931:Microcystis / Q000737:chemistry* / Q000254:growth & development; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D016339:Spectrometry, Mass, Fast Atom Bombardment
C420867:Leu(1)microcystin-LR; D052998:Microcystins; D010456:Peptides, Cyclic