title: Sevoflurane (0.4 MAC) does not influence cerebral compliance in healthy individuals.
abstract: The use of sevoflurane is favored for its rapid onset and offset of anesthesia as well as good intraoperative titratability of the anesthetic. With regard to neuroanesthesia, the reported effects of sevoflurane on cerebral hemodynamics and cerebrospinal fluid dynamics are inconsistent. We used phase-contrast magnetic resonance imaging measurement of systolic cerebrospinal fluid peak velocity (CSFVPeak) to evaluate the effect of sevoflurane on cerebral compliance in healthy individuals. During administration of 0.4 MAC sevoflurane, systolic CSFVPeak in the aqueduct of Sylvius remained unchanged, thereby indicating unaffected cerebral compliance: (CSFVPeak baseline: -3.1 +/- 1.0 cm/s vs. sevoflurane: -3.0 +/- 1.2 cm/s). We conclude that low-dose administration of sevoflurane does not influence cerebral compliance in healthy individuals, but the influence of coexisting intracranial pathology or comedications on cerebral compliance requires further clinical investigation.
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, University of Innsbruck, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Kolbitsch
authors.forename: H I
authors.initials: HI
authors.lastname: Lorenz
authors.forename: C
authors.initials: C
authors.lastname: Hörmann
authors.forename: M
authors.initials: M
authors.lastname: Schocke
authors.forename: S
authors.initials: S
authors.lastname: Felber
authors.forename: F
authors.initials: F
authors.lastname: Zschiegner
authors.forename: P K
authors.initials: PK
authors.lastname: Pfeiffer
authors.forename: A
authors.initials: A
authors.lastname: Benzer
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D018685:Anesthetics, Inhalation / Q000008:administration & dosage; D001921:Brain / Q000187:drug effects* / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000502:physiology*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D004305:Dose-Response Relationship, Drug; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D011446:Prospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D003287:Contrast Media; D008738:Methyl Ethers; D000077149:Sevoflurane