title: The management of the clinical complications of antiretroviral therapy.
abstract: In clinical practice, combination antiretroviral therapy is frequently complicated by adverse reactions and drug-related toxicities. The incidence, presentation, differential diagnosis, and management of the most frequent and severe of these complications are discussed. The recently described spectrum of metabolic complications, including hyperlipidemia, fat redistribution, and lactic acidosis, are covered in detail. The management of nephrotoxicity, pancreatitis, bone marrow suppression, peripheral neuropathy, and hypersensitivity reactions related to antiretroviral therapy is also discussed.
authors.affiliation: Vancouver Clinic, Vancouver, Washington, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Stenzel
authors.forename: C C
authors.initials: CC
authors.lastname: Carpenter
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D052776:Female Urogenital Diseases / Q000139:chemically induced / Q000628:therapy; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects; D006801:Humans; D052801:Male Urogenital Diseases; D008659:Metabolic Diseases / Q000139:chemically induced / Q000628:therapy; D009422:Nervous System Diseases / Q000139:chemically induced / Q000628:therapy; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors