Nitric oxide and molsidomine in the management of pulmonary hypertension in Takayasu's arteritis.
We present three patients with pulmonary hypertension in Takayasu's arteritis who showed long-term favorable response, clinically and hemodynamically, to nitric oxide donor molsidomine. In these patients, nitric oxide inhalation was effective in reducing pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR). Molsidomine (single dose of 4 mg p.o.) was also effective in reducing PAP and PVR, but nifedipine was not. With molsidomine, 4 mg tid, dyspnea, exercise capacity, and hemodynamic parameters were improved. These favorable responses have lasted during the 3-month follow-up period in all patients.
Lee
S D
SD
Department of Internal Medicine, Asan Medical Center, College of Medicine, Ulsan University, Seoul, Korea. sdlee@www.amc.seoul.kr
Kim
D S
DS
Shim
T S
TS
Lim
C M
CM
Koh
Y
Y
Kim
W S
WS
Kim
W D
WD
D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008981:Molsidomine / Q000008:administration & dosage*; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D013625:Takayasu Arteritis / Q000188:drug therapy*; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000187:drug effects
D020030:Nitric Oxide Donors; D008981:Molsidomine