The oxidation of 9-cis-retinol: a possible synthesis pathway for 9-cis-retinoic acid.
A short-chain alcohol dehydrogenase has been discovered that oxidizes 9-cis- and 11-cis-retinol to their corresponding aldehydes. The gene for this enzyme was sequenced and appears to be expressed with highest efficiency in the retinal pigment epithelium of the eye, as well as in human liver and mammary gland and in mouse liver and kidney. Because 9-cis-retinol occurs in liver, it may be a precursor of 9-cis-retinoic acid.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000077556:Alitretinoin; D000818:Animals; D001940:Breast / Q000201:enzymology; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology*; D051379:Mice; D010084:Oxidation-Reduction; D010857:Pigment Epithelium of Eye / Q000201:enzymology*; D014212:Tretinoin / Q000378:metabolism*; D014801:Vitamin A / Q000378:metabolism*
D014801:Vitamin A; D000077556:Alitretinoin; D014212:Tretinoin; D000429:Alcohol Oxidoreductases; C105846:retinol dehydrogenase 5