title: Gamma-hydroxybutyrate overdose and physostigmine: teaching new tricks to an old drug?
abstract: Gamma-hydroxybutyrate was introduced as an anesthetic agent in the 1960s and is still used in some countries, despite recognized disadvantages. More recently, it has emerged as a popular recreational drug. We report 3 cases of gamma-hydroxybutyrate overdose, the effects of which were reversed by the administration of low-dose intravenous physostigmine. The origins of this regimen and the case for physostigmine as a potential antidote are described.
authors.affiliation: Emergency Department, Royal Adelaide Hospital, Adelaide, SA, Australia.
authors.forename: D G
authors.initials: DG
authors.lastname: Caldicott
authors.forename: M
authors.initials: M
authors.lastname: Kuhn
mesh_terms: D000328:Adult; D000931:Antidotes / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D062787:Drug Overdose / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D010830:Physostigmine / Q000627:therapeutic use*; D012978:Sodium Oxybate / Q000506:poisoning*
chemical_list: D000931:Antidotes; D002800:Cholinesterase Inhibitors; D012978:Sodium Oxybate; D010830:Physostigmine