title: Successful haploidentical bone marrow transplantation in Fanconi anemia.
abstract: A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available.
authors.affiliation: Department of Pediatric Hemato-Oncology, Rambam Medical Center and Technion, Haifa, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Elhasid
authors.forename: M W
authors.initials: MW
authors.lastname: Ben Arush
authors.forename: T
authors.initials: T
authors.lastname: Katz
authors.forename: Y
authors.initials: Y
authors.lastname: Gan
authors.forename: Y
authors.initials: Y
authors.lastname: Shechter
authors.forename: I
authors.initials: I
authors.lastname: Sami
authors.forename: S
authors.initials: S
authors.lastname: Postovsky
authors.forename: Y
authors.initials: Y
authors.lastname: Reisner
authors.forename: J M
authors.initials: JM
authors.lastname: Rowe
mesh_terms: D018952:Antigens, CD34 / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods; D002648:Child; D005199:Fanconi Anemia / Q000628:therapy*; D005220:Fathers; D005260:Female; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D018189:Immunomagnetic Separation; D019520:Living Donors; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D018952:Antigens, CD34; D006680:HLA Antigens