[Efficiency of etidronic acid in the case of cutaneous radiocontamination by actinid elements: in vitro evaluation].
Ethane 1 hydroxy 1.1. biphosphonate (EHBP) is a medicine named Didronel, which inhibits bone resorption in the case of Paget's disease. This molecule could offer a new application in radiotoxicology. Our works describe its efficiency as decontaminating agent in uranium and plutonium cutaneous radiocontamination. Its effect on uranium and plutonium is demonstrated by two in vitro techniques using human cutaneous explants. Both techniques are usually used in dermopharmacology to estimate the action of topic drugs.
Tymen
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Laboratoire de contrôle radiotoxicologique, Service de Protection Radiologique des Armées, 1 bis, rue du Lieutenant Raoul Batany, F 92141, Clamart Cedex.
Hoffschir
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Gerasimo
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Marty
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JP
D002614:Chelating Agents / Q000494:pharmacology*; D003666:Decontamination / Q000379:methods*; D012968:Etidronic Acid / Q000494:pharmacology*; D006801:Humans; D009924:Organ Culture Techniques; D004369:Pentetic Acid / Q000494:pharmacology; D011005:Plutonium; D012867:Skin / Q000187:drug effects; D014501:Uranium
D002614:Chelating Agents; D014501:Uranium; D011005:Plutonium; D004369:Pentetic Acid; D012968:Etidronic Acid