Differentiated therapy with prostaglandin E1 (alprostadil) after orthotopic liver transplantation: the usefulness of procalcitonin (PCT) and hepatic artery resistive index (RI) for the evaluation of early graft function and clinical course.
Increasing demand for donor organs has led to new pharmacological concepts for reducing ischemia-reperfusion injury (I/R) of the graft after liver transplantation to prevent primary non-functioning of the organ. Prostaglandins have proved to be cytoprotective in several experimental models of ischemia and transplantation. The prophylactic administration after orthotopic liver transplantation is still a subject of controversial discussion. The aim of our study was the evaluation of the post-transplant hepatic artery resistive index (RI) measured by color Doppler imaging, in combination with postoperative elevation of transaminases, as parameters indicating the need for a differentiated systemic therapy with prostaglandin E1 (PGE1) (alprostadil). In addition, the value of serum procalcitonin (PCT) as a postoperative parameter for the extent of I/R is investigated. In the case of post-transplant elevated hepatic artery RI (RI > 0.75), the administration of PGE1 led to a significant reduction of transaminases (p < 0.05) and a decline of the RI. In addition, postoperative PCT levels could be reduced significantly by PGE1 application. These results suggest that determination of RI is feasible for indicating a need for therapy with PGE1. Its targeted application reduces hepatocellular damage due to I/R after liver transplantation.
Kornberg
A
A
Department of General and Visceral Surgery, Friedrich-Schiller-University, Jena, Germany. Kornberg@bach.med.uni-jena.de
Grube
T
T
Wagner
T
T
Voigt
R
R
Homman
M
M
Schotte
U
U
Schmidt
K
K
Scheele
J
J
D000527:Alprostadil / Q000627:therapeutic use*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D006085:Graft Survival; D006499:Hepatic Artery / Q000502:physiology*; D006801:Humans; D016031:Liver Transplantation; D011498:Protein Precursors / Q000097:blood*; D000637:Transaminases / Q000097:blood; D014655:Vascular Resistance
C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D000637:Transaminases; D000527:Alprostadil; D015740:Calcitonin Gene-Related Peptide