The therapeutic potential of iron chelators.
In recent years there has been much interest in the development of iron (Fe) chelators for treatment of a number of clinical conditions in addition to beta-thalassaemia. These include cancer, anthracycline-mediated cardiotoxicity, malaria, AIDS and the severe neurodegenerative disease, Friedreich's ataxia. In this review I will discuss the most recent advances achieved in the potential treatment of these conditions using Fe chelators.
Richardson
DR
Department of Medicine, University of Queensland, Clinical Sciences Building Floor C, Royal Brisbane Hospital, Brisbane, Australia. D.Richardson@medicine.herston.uq.edu.au