Successful treatment of hypothalamic seizures and precocious puberty with GnRH analogue.
Patients with hypothalamic hamartomas and precocious puberty may develop gelastic seizures that are resistant to conventional antiepileptic drug therapies. While treating precocious puberty in two such patients with long-acting GnRH analogue, the authors observed cessation of gelastic seizures. Although the mechanism is unclear, long-acting GnRH analogue should be considered as a possible therapy for gelastic seizures in patients with hypothalamic hamartomas.
Zaatreh
M
M
Department of Neurology and Pediatric Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. mmzid@med.unc.edu
Tennison
M
M
Greenwood
R S
RS
D000293:Adolescent; D001927:Brain Diseases / Q000188:drug therapy*; D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D006222:Hamartoma / Q000188:drug therapy*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects; D011629:Puberty, Precocious / Q000097:blood / Q000188:drug therapy*
D007987:Gonadotropin-Releasing Hormone