Experimental models of atrial fibrillation/flutter.
Animal models that mimic disease states or abnormal physiological events are tools that assist the investigator to understand the mechanism responsible for pathophysiological conditions. Atrial arrhythmias have intrigued physicians and cardiologists for decades. Thus the development of animal models for the study of atrial arrhythmias facilitate the investigation of these abnormal rhythms. Moreover, as our understanding of arrhythmias advances, so does the therapy designed to correct the condition, which ultimately improves the patient's clinical outcome. This manuscript describes a variety of animal models that have been utilized for the exploration of atrial arrhythmia generation and maintenance, as well as models used to evaluate the efficacy of putative antiarrhythmics agents.
Friedrichs
G S
GS
Division of Women's Health/Cardiovascular, Wyeth-Ayerst Research, Mailstop 3061, 145 King of Prussia Road, Radnor, PA 19087, USA. friedrg@war.wyeth.com
D000818:Animals; D001281:Atrial Fibrillation / Q000209:etiology*; D001282:Atrial Flutter / Q000209:etiology*; D002304:Cardiac Pacing, Artificial; D003198:Computer Simulation; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D014630:Vagus Nerve / Q000502:physiology