[Protective effect of L-arginine on liver during ischemia-reperfusion injury].
OBJECTIVE
To explore the protective effect of L-arginine (L-Arg) on liver during hepatic ischemia-reperfusion injury (HIRI) and its mechanisms.


METHODS
Changes of several parameters, including nitric oxide (NO), malondiadehyde (MDA), thromboxane B(2) ( TXB(2) ), 6-keto-prostaglandin F(1-alpha) (6-keto-PGF(1-alpha) ), TXB(2) / 6-keto-PGF(1-alpha) ( T / K ) and alanine aminotransferase (ALT) as well as liver morphological changes, and the effect of L-Arg on them were observed during HIRI in 20 rabbits and 18 patients who were scheduled for elective hepatic surgery.


RESULTS
The levels of NO and 6-keto-PGF(1-alpha) decreased remarkably. MDA concentration, TXB(2) content and T / K ratio as well as ALT activity increased significantly. The morphological changes of hepatocytes were obvious during HIRI. After treatment with L-Arg, the variations of all the parameters were markedly alleviated.


CONCLUSIONS
L-Arg possess preventive effects on HIRI by raising NO and reducing MDA as well as correcting TXA(2) / PGI(2) imbalance after hepatic ischemia-reperfusion.
Wang
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W
Department of Pathophysiology, Wenzhou Medical College, Wenzhou 325003, China.
Xu
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Z
Lin
L
L
Wang
W
W
Li
D
D
Wang
Z
Z
D000328:Adult; D000368:Aged; D000818:Animals; D001120:Arginine / Q000627:therapeutic use*; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007511:Ischemia / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000098:blood supply* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009569:Nitric Oxide / Q000032:analysis; D011817:Rabbits; D015427:Reperfusion Injury / Q000517:prevention & control*; D013928:Thromboxane A2 / Q000096:biosynthesis
D009569:Nitric Oxide; D008315:Malondialdehyde; D013928:Thromboxane A2; D001120:Arginine; D011464:Epoprostenol