title: Effects of black current anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alteration in healthy humans.
abstract: The effects of oral intake of a black currant anthocyanosides (BCA) concentrate on dark adaptation, video display terminal (VDT) work-induced transient refractive alteration, and subjective asthenopia symptoms (visual fatigue) were examined in a double-blind, placebo-controlled, crossover study with healthy human subjects. In a dark adaptation study, intake of BCA at three dose levels (12.5-, 20-, and 50 mg/subject, n = 12) appeared to bring about dose-dependent lowering of the dark adaptation threshold. Statistical analysis comparing the values before and after intake indicated there was a significant difference at the 50 mg dose (p= 0. 011). Comparing the refraction values for the dominant eye, BCA intake (50 mg/subject, n = 21) resulted in no decrease in the average value after the visual task; whereas, a placebo trial resulted in a large decrease in the average value, resulting in borderline significance (p = 0.064). In the assessment of subjective asthenopia symptoms by questionnaire, significant improvement was recognized on the basis of the statements regarding the eye and lower back after BCA intake.
authors.affiliation: University of Tsukuba (Department of Public Health, College of Medical Technology and Nursing), 167-0031, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakaishi
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: S
authors.initials: S
authors.lastname: Tominaga
authors.forename: M
authors.initials: M
authors.lastname: Hirayama
mesh_terms: D000328:Adult; D000872:Anthocyanins / Q000627:therapeutic use*; D001248:Asthenopia / Q000188:drug therapy*; D016288:Computer Terminals; D018592:Cross-Over Studies; D003623:Dark Adaptation / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D012030:Refractive Errors / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000872:Anthocyanins; D010936:Plant Extracts