Benign metastasizing leiomyoma of the lung: a case report.
Benign metastasizing leiomyoma (BML) refers to benign pulmonary neoplasm associated with a previous or coincident history of uterine leiomyomata. We report the case of a 56-year-old postmenopausal woman with a 4-year history of multiple benign leiomyomatous lesions in bilateral lungs and the uterus. The tumor cells from the lungs and uterus were focally immunoreactive for HMB-45 antibody and progesterone receptor. Immunoreactivity to HMB-45 is well known in smooth muscle cells of hamartomatous neoplasms, such as angiomyolipoma and lymphangioleiomyomatosis, but has not been reported in BML previously. These features suggest a multifocal hamartomatous histogenesis rather than metastasis in the present case.
Huang
P C
PC
Department of Pathology, Taichung Hospital Department of Health, 199, Section 1, San-Min Road, Taichung, Taiwan.
Chen
J T
JT
Chia-Man
C
C
Kwan
P C
PC
Ho
W L
WL
D000951:Antigens, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D018231:Leiomyomatosis / Q000737:chemistry / Q000175:diagnosis* / Q000276:immunology; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000276:immunology / Q000556:secondary; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000175:diagnosis* / Q000276:immunology; D011980:Receptors, Progesterone / Q000032:analysis; D014594:Uterine Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology
D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D011980:Receptors, Progesterone