title: Transient neurologic symptoms after spinal anesthesia with lidocaine in obstetric patients.
abstract: We investigated the relationship between intrathecal lidocaine and transient neurologic symptoms in the obstetric population because lidocaine spinal anesthetics are commonly used for various obstetric procedures, and little has been reported in this regard from within this population. In this study, 58 ASA physical status I patients presenting for postpartum bilateral tubal ligation under spinal anesthesia were randomized to receive either hyperbaric 5% lidocaine or 0.75% bupivacaine in a double-blinded manner. All patients were in the supine position for their surgery. Postoperatively, all patients were followed by a blinded investigator using a standardized symptom checklist. The incidence of transient neurologic symptoms with lidocaine was 3% (95% confidence interval = 0.1%--17.8%) and that with bupivacaine was 7% (95% confidence interval = 0.9%--23.5%), (P = not significant). Symptoms consistent with this syndrome occurred within 24 h without any associated sensory or motor deficits or functional impairment, and resolved within 48 h without any intervention.
authors.affiliation: Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA. john.philip@email.swmed.edu
authors.forename: J
authors.initials: J
authors.lastname: Philip
authors.forename: S K
authors.initials: SK
authors.lastname: Sharma
authors.forename: V N
authors.initials: VN
authors.lastname: Gottumukkala
authors.forename: B J
authors.initials: BJ
authors.lastname: Perez
authors.forename: E A
authors.initials: EA
authors.lastname: Slaymaker
authors.forename: J
authors.initials: J
authors.lastname: Wiley
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects*; D002045:Bupivacaine / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D008012:Lidocaine / Q000009:adverse effects*; D011247:Pregnancy; D013116:Spinal Cord / Q000187:drug effects*
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; D002045:Bupivacaine