Characterization of the novel allele HLA-B*4417: implications for bone marrow transplantation.
The identification of the novel allele HLA-B*4417, which was found in a blood donor of Caucasian origin, is described. In the sequence analysis the new allele differs from B*4402 by three nucleotides in exon 3. At the protein level, the new allele has two residue differences compared to B*4402. Due to substantial differences with other B*44 variants a possible mismatch may impair clinical outcome of bone marrow transplantation.
Elsner
H A
HA
Department of Transfusion Medicine, Hannover Medical School, Germany.
Schmitz
G
G
Ballas
M
M
Lenhard
V
V
Blasczyk
R
R
D000483:Alleles; D001483:Base Sequence; D016026:Bone Marrow Transplantation; D018076:DNA, Complementary; D005091:Exons; D015235:HLA-B Antigens / Q000145:classification / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D018076:DNA, Complementary; D015235:HLA-B Antigens