Preeclampsia and Na,K-ATPase activity of red blood cell ghosts from neonatal and maternal blood.
We determined Na,K-ATPase activity and cholesterol/phospholipid ratio of maternal and cord red blood cell ghosts from either normotensive or preeclamptic pregnant women. The Na,K-ATPase activity of the red cell ghosts from neonatal blood is significantly lower (25-32%) as compared with the ATPase activity of the maternal red cell ghosts, regardless of the presence or not of preeclampsia. This diminution in Na,K-ATPase activity of the neonatal red blood cell ghosts could be due to an increase in the cholesterol/phospholipid molar ratio of the membrane. The Na,K-ATPase activity of the red blood cell ghosts from pregnant women was unaffected by preeclampsia; however, fetal red blood cell ghosts from infants of preeclamptic mothers showed a significantly lower ATPase activity (20%) than fetal red blood cell ghosts from infants of normotensive mothers. A low Na,K-ATPase activity in the neonatal red blood cells from mothers with preeclampsia could be an indication of an important modification of the physiological role of this enzyme.
Carreiras
M M
MM
Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científícas y Fundamatín, Maternidad Concepción Palacios, Caracas, Venezuela.
Proverbio
T
T
Proverbio
F
F
Marín
R
R
D002784:Cholesterol / Q000097:blood; D004910:Erythrocyte Membrane / Q000201:enzymology*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology; D006801:Humans; D007231:Infant, Newborn; D008563:Membrane Lipids / Q000097:blood; D010743:Phospholipids / Q000097:blood; D011225:Pre-Eclampsia / Q000201:enzymology*; D011247:Pregnancy; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase