title: Efficient syntheses of imidazolo[1,2-a]pyridines and -[2, 1-a]isoquinolines.
abstract: 2-Aminopyridines 1a-c and 1-aminoisoquinoline with 1-chloromethylbenzotriazole give 2-amino-1-[alpha-benzotriazol-1-ylmethyl]pyridinium chlorides 2a-c and 1-amino-2-(alpha-benzotriazol-1-ylmethyl)isoquinolinium++ + chloride 12, respectively. Compounds 2a-c and 12 react with aryl aldehydes 3a-h to afford imidazolo[1,2-a]pyridines 7a-k and imidazolo[2, 1-a]isoquinolines 13a,b in good yields.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: A R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: G
authors.initials: G
authors.lastname: Qiu
authors.forename: Q H
authors.initials: QH
authors.lastname: Long
authors.forename: H Y
authors.initials: HY
authors.lastname: He
authors.forename: P J
authors.initials: PJ
authors.lastname: Steel
mesh_terms: D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D007546:Isoquinolines; D011725:Pyridines