title: Impact of hollow-fiber membrane surface area on oxygenator performance: Dideco D903 Avant versus a prototype with larger surface area.
abstract: This study compares the gas transfer capacity, the blood trauma, and the blood path resistance of the hollow-fiber membrane oxygenator Dideco D 903 with a surface area of 1.7 m2 (oxygenator 1.7) versus a prototype built on the same principles but with a surface area of 2 m2 (oxygenator 2). Six calves (mean body weight: 68.2 +/- 3.2 kg) were connected to cardiopulmonary bypass (CPB) by jugular venous and carotid arterial cannulation, with a mean flow rate of 4 l/min for 6 h. They were randomly assigned to oxygenator 1.7 (N = 3) or 2 (N = 3). After 7 days, the animals were sacrificed. A standard battery of blood samples was taken before the bypass, throughout the bypass, and 24 h, 48 h, and 7 days after the bypass. The oxygenator 2 group showed significantly better total oxygen and carbon dioxide transfer values throughout the perfusion (p < .001 for both comparison). Hemolytic parameters (lactate dehydrogenase and free plasma hemoglobin) exhibited a slight but significant increase after 5 h of bypass in the oxygenator 1.7 group. The pressure drop through the oxygenator was low in both groups (range, 43-74 mmHg). With this type of hollow-fiber membrane oxygenator, an increased surface of gas exchange from 1.7 m2 to 2 m2 improves gas transfer, with a limited impact on blood trauma and no increase of blood path resistance.
authors.affiliation: Clinic for Cardiovascular Surgery, CHUV (Centre Hospitalier Universitaire Vaudois), Switzerland. Xavier.Mueller@chuv.hospvd.ch
authors.forename: X M
authors.initials: XM
authors.lastname: Mueller
authors.forename: H T
authors.initials: HT
authors.lastname: Tevaearai
authors.forename: D
authors.initials: D
authors.lastname: Jegger
authors.forename: Y
authors.initials: Y
authors.lastname: Boone
authors.forename: M
authors.initials: M
authors.lastname: Augstburger
authors.forename: L K
authors.initials: LK
authors.lastname: von Segesser
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D002417:Cattle; D013677:Medical Laboratory Science; D008567:Membranes, Artificial; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D014481:United States
chemical_list: D008567:Membranes, Artificial; D002245:Carbon Dioxide; D010100:Oxygen