Effect of long-term changes in diet and exercise on plasma leptin concentrations.
BACKGROUND
Although it is known that plasma leptin concentrations correlate with the amount of adipose tissue in the body, little information is available on the long-term effects on leptin concentrations of changes in diet and exercise.


OBJECTIVE
We wanted to examine whether changes in dietary energy sources and exercise-mediated energy expenditure, alone or in combination, affect plasma leptin concentrations.


METHODS
In a randomized, 2 x 2 factorial trial, 186 men with metabolic syndrome were divided into 4 groups: diet, exercise, a combination of diet and exercise, and control. Data on dietary intake, physical fitness, and demographics were collected and plasma leptin concentrations were measured before and after a 1-y intervention period.


RESULTS
Plasma leptin concentrations, body mass index, and fat mass decreased in association with long-term reductions in food intake as well as increased physical activity. By adjusting for either body mass index or fat mass, we observed a highly significant reduction in plasma leptin concentration after both the diet and the exercise interventions. There was no interaction between the interventions, suggesting a direct and additive effect of changes in diet and physical activity on plasma leptin concentrations.


CONCLUSIONS
Long-term changes in lifestyle consisting of decreased intake of dietary fat and increased physical activity reduced plasma leptin concentrations in humans beyond the reduction expected as a result of changes in fat mass.
Reseland
J E
JE
Institute for Nutrition Research, University of Oslo, Norway. j.e.reseland@basalmed.uio.no
Anderssen
S A
SA
Solvoll
K
K
Hjermann
I
I
Urdal
P
P
Holme
I
I
Drevon
C A
CA
D000273:Adipose Tissue; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D015444:Exercise; D015438:Health Behavior; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking; D015431:Weight Loss
D004041:Dietary Fats; D020738:Leptin