title: Vitamin B12 and hepatic enzyme serum levels correlate in male alcohol-dependent patients.
abstract: - Vitamin B12 serum levels and markers for alcohol consumption were determined in 80 male alcohol-dependent patients. Spearman correlation coefficients (r(S)) were calculated. Significant positive correlations between vitamin B12 and hepatic enzyme values were found (gamma-glutamyltransferase: r(S) = 0.58; alanine aminotransferase: r(S) = 0.43; aspartate aminotransferase: r(S) = 0.47; glutamate dehydrogenase: r(S) = 0.43; all P: < 0.001). Therefore, for a proper interpretation of vitamin B12 levels, it may be clinically relevant to take markers of hepatocellular damage into account.
authors.affiliation: Department of Psychiatry, University of Mainz, Untere Zahlbacherstr. 8, D-55131 Mainz, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Himmerich
authors.forename: I
authors.initials: I
authors.lastname: Anghelescu
authors.forename: C
authors.initials: C
authors.lastname: Klawe
authors.forename: A
authors.initials: A
authors.lastname: Szegedi
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000437:Alcoholism / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004909:Erythrocyte Indices / Q000502:physiology; D005969:Glutamate Dehydrogenase / Q000097:blood; D006801:Humans; D008099:Liver / Q000201:enzymology; D008108:Liver Diseases, Alcoholic / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism; D014805:Vitamin B 12 / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; D005969:Glutamate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D014805:Vitamin B 12