title: Near-infrared two-photon excitation of protoporphyrin IX: photodynamics and photoproduct generation.
abstract: The spectroscopy and photochemistry of protoporphyrin IX in ethanol and in Triton X-100 micelle solution have been examined using near-infrared two-photon excitation (TPE). TPE will allow photodynamic therapy with highly localized light dosage. We have determined that the photochemistry subsequent to TPE is very similar to that found for one-photon excitation. Moreover, the photoproducts observed possess very intense TPE fluorescence spectra, which allows their detection at low relative concentrations.
authors.affiliation: Department of Chemistry, University of Calgary, Calgary, Alberta, Canada.
authors.forename: R L
authors.initials: RL
authors.lastname: Goyan
authors.forename: D T
authors.initials: DT
authors.lastname: Cramb
mesh_terms: D005453:Fluorescence; D007700:Kinetics; D017785:Photons; D011524:Protoporphyrins / Q000737:chemistry*
chemical_list: D011524:Protoporphyrins; C028025:protoporphyrin IX