The effects of octylcyanoacrylate on scarring after burns.
OBJECTIVE
To compare the effects of octylcyanoacrylate (OCA), silver sulfadiazine (SSD), polyurethane film (PU), and dry gauze (G) on scarring three months after partial-thickness burns.


METHODS
This was a prospective, blinded, controlled experimental trial using isoflurane-anesthetized swine. Standardized partial-thickness burns were inflicted by applying an aluminum bar preheated to 80 degrees C to the backs and flanks of a young pig for 20 seconds. Four equal sets of ten burns each were randomly treated with OCA spray, SSD, PU, or G. Dressing changes were performed on days 1, 2, 3, and 4 after injury. Digital images of the burns were obtained immediately and three months later for masked computerized determination of scar surface area. Full-thickness biopsies were taken at three months for masked histopathological evaluation. The primary outcome was the percent reduction in residual wound area (RWA) calculated by subtracting the area of each individual burn from the area of the largest burn and dividing this value by the area of the largest burn (intraobserver correlation, r = 0.99). Secondary outcomes were the proportion of burns with the presence of scar tissue (abnormal collagen under polarized light; intraobserver agreement, kappa = 0.93) and the cosmetic appearance on a 100-mm visual analog scale marked "best scar" at the high end (inter-observer correlation, r = 0.82). Analysis of variance (ANOVA) and chi(2) tests were used for group comparisons as appropriate. This study had 80% power to detect a 33-percentage-point difference in RWA among groups (alpha = 0.05).


RESULTS
A total of 40 burns were inflicted on the pig. There was no difference in percent RWA across the groups (OCA = 25%, SSD = 40%, PU = 25%, G = 32%; p = 0.13). There was no difference in the proportion of wounds with scarring among the groups (OCA = 10%, SSD = 22%, PU = 2%, G = 30%; p = 0.89). There was also no difference in the cosmetic scores among the groups (OCA = 78 mm, SSD = 75 mm, PU = 74 mm, G = 74 mm; p = 0.96).


CONCLUSIONS
The effects of OCA spray, SSD, PU, and dry gauze on scarring three months after burns in pigs are similar.
Singer
A
A
Department of Emergency Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA. asinger@epo.som.sunysb.edu
Thode
H
H
McClain
S
S
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001458:Bandages; D002056:Burns / Q000188:drug therapy*; D002921:Cicatrix; D003487:Cyanoacrylates / Q000627:therapeutic use*; D005260:Female; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D013552:Swine; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D003487:Cyanoacrylates; C119247:octylcyanoacrylate; D012837:Silver Sulfadiazine