title: An autopsy case of Alzheimer's disease with a progressive supranuclear palsy overlap.
abstract: A 74-year-old man developed abnormal forgetfulness, soon followed by unstable speech content and marked disorientation. At 77 years of age, the patient started to occasionally fall, an aspect of progressive supranuclear palsy. He then became bedridden. The patient eventually died of pneumonia at 79 years of age. Neuropathological examination revealed profiles of both progressive supranuclear palsy and Alzheimer's disease. Although the two conditions both belong to tauopathy, their pathologically proven combination was rare. Furthermore, the case had the possibility of being a subgroup of tauopathy.
authors.affiliation: Department of Pathology, Omiya Medical Center, Jichi Medical School, Amanuma, Japan. kurasaki@jichi.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Urasaki
authors.forename: K
authors.initials: K
authors.lastname: Kuriki
authors.forename: M
authors.initials: M
authors.lastname: Namerikawa
authors.forename: S
authors.initials: S
authors.lastname: Satoh
authors.forename: K
authors.initials: K
authors.lastname: Ikeguchi
authors.forename: M
authors.initials: M
authors.lastname: Fukayama
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: I
authors.initials: I
authors.lastname: Nakano
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000032:analysis; D001921:Brain / Q000473:pathology*; D006801:Humans; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D058225:Plaque, Amyloid / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis
chemical_list: D016229:Amyloid beta-Peptides; D016875:tau Proteins