[Intermitochondrial contacts in a system of cardiomyocyte mitochondriome in a normal state, under physiological stress, and in pathology].
Intermitochondrial contacts are universal and indispensable structures participating in the formation of mitochondriome in cardiomyocytes of invertebrate and vertebrate animals; they participate in the maintenance of the energy pool required for rhythmic contractions of the heart. At the ultrastructural level, a direct relationship is demonstrated between the functional load on the heart and the number of intermitochondrial contacts in cardiomyocytes of swifts and rats: there was a twofold increase in the number of these contacts associated in actively flying adult birds as compared with chicks; a similar effect was observed in response to pressure overload associated with aortal stenosis; hypokinesia and hypoxia led to a twofold or even threefold decrease in their number.
Shornikova
M V
MV
Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
D000818:Animals; D006331:Heart Diseases / Q000473:pathology*; D008929:Mitochondria, Heart / Q000502:physiology / Q000648:ultrastructure*; D009200:Myocardial Contraction; D013045:Species Specificity