Cell polarity: the PARty expands.
Recent work has revealed an evolutionarily conserved trio of proteins that regulate cell polarity in epithelial cells, embryonic blastomeres and neural precursors. This common cell-polarity mechanism is used in cell-specific ways, as highlighted by the recent finding that at least two different types of asymmetric division are observed in Drosophila neural precursors.
Doe
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Institute of Molecular Biology and the Institute of Neuroscience, HHMI, University of Oregon, Eugene, Oregon 97403, USA. cdoe@uoneuro.uoregon.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology / Q000235:genetics; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002455:Cell Division / Q000235:genetics; D016764:Cell Polarity / Q000235:genetics; D004330:Drosophila / Q000166:cytology / Q000196:embryology / Q000235:genetics; D029721:Drosophila Proteins; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D009865:Oocytes / Q000166:cytology / Q000254:growth & development / Q000378:metabolism; D011493:Protein Kinase C / Q000235:genetics / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D014981:Xenopus / Q000196:embryology / Q000235:genetics; D029867:Xenopus Proteins; D015053:Zygote / Q000166:cytology / Q000254:growth & development / Q000378:metabolism
C400774:baz protein, Drosophila; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D029721:Drosophila Proteins; D015801:Helminth Proteins; D047908:Intracellular Signaling Peptides and Proteins; C097238:PAR-3 protein, C elegans; C512642:par-6 protein, C elegans; C512643:PARD6B protein, Xenopus; C115015:PKC-3 protein; D011493:Protein Kinase C; D017346:Protein Serine-Threonine Kinases; D011506:Proteins; D029867:Xenopus Proteins