Sealing effect of hydroxyapatite coating: a 12-month study in canines.
This study addresses the clinical problems regarding access of wear debris to the bone-implant interface and the possible dissemination of polyethylene (PE) particles to distant organs. We inserted two implants into each knee of 7 dogs allowing access of joint fluid to the bone-implant interface with a 0.75 mm initial gap around the implant. Hydroxyapatite (HA)-coated and non-coated (Ti) titanium alloy implants were randomly allocated to each distal femoral condyle. PE particles were repeatedly injected into the right knee joint 3 weeks after surgery for a period of 49 weeks, while only vehicle was injected into the left knee joint. We found huge amounts of PE particles mainly in the bone-implant interface around Ti implants. Infiltration of mononuclear inflammatory cells was present around 3 of 7 Ti implants in relation to PE particles. HA implants had approximately 70% bone ongrowth. In contrast, no bone ongrowth was seen on any Ti implants, all being surrounded by a fibrous membrane. The number of PE particles was evaluated semi-quantitatively. More PE particles were found around Ti implants than with HA implants (p < 0.002). Specimens from iliac lymph nodes, liver, spleen and lung were examined and showed dissemination of PE particles only in regional lymph nodes.
Rahbek
O
O
Department of Orthopaedics, Aarhus University Hospital, Denmark. ole.rahbek@dadlnet.dk
Overgaard
S
S
Jensen
T B
TB
Bendix
K
K
Søballe
K
K
D000818:Animals; D001363:Awards and Prizes; D001672:Biocompatible Materials / Q000627:therapeutic use*; D004285:Dogs; D017886:Durapatite / Q000627:therapeutic use*; D007720:Knee Prosthesis; D010014:Osteolysis / Q000517:prevention & control*; D011475:Prosthesis Failure
D001672:Biocompatible Materials; D017886:Durapatite