A new C-nucleoside analogue of tiazofurin: synthesis and biological evaluation of 2-beta-D-ribofuranosylimidazole-4-carboxamide (imidazofurin).
2-Beta-D-ribofuranosylimidazole-4-carboxamide, an imidazole analogue of the antitumor agent tiazofurin, was synthesized and evaluated for the growth inhibitory activity of human myelogenous leukemia K562 cells.
Franchetti
P
P
Departamento di Science Chimiche, Università di Camerino, Italy. frapa@camserv.unicam.it
Marchetti
S
S
Cappellacci
L
L
Yalowitz
J A
JA
Jayaram
H N
HN
Goldstein
B M
BM
Grifantini
M
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007168:IMP Dehydrogenase / Q000037:antagonists & inhibitors; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020014:K562 Cells; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000494:pharmacology*; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
C422504:2-ribofuranosylimidazole-4-carboxamide; D000970:Antineoplastic Agents; D007093:Imidazoles; D009005:Monosaccharides; D012254:Ribavirin; D007168:IMP Dehydrogenase; C033706:tiazofurin