Enantioselective addition of 2-methyl-3-butyn-2-ol to aldehydes: preparation of 3-hydroxy-1-butynes
We report the first example of enantioselective aldehyde additions of 2-methyl-3-butyn-2-ol, a commodity bulk chemical that is readily available. Following a facile fragmentation reaction, the addition reactions provide access to optically active terminal acetylenes as useful building blocks for asymmetric synthesis.
Boyall
D
Laboratorium fur Organische Chemie, ETH-Zentrum, Universitatstrasse 16, CH-8092 Zurich, Switzerland.
Lopez
F
Sasaki
H
Frantz
D
Carreira
EM