title: Estimating pulmonary capillary wedge pressures using Doppler variables of early diastolic left ventricular inflow.
abstract: The present study was performed to determine whether a multilineal regression model based on the early diastolic transmitral flow peak velocity (E) and the propagation velocity of early diastolic inflow (PV) could estimate the pulmonary capillary wedge pressure (PCWP). PCWP and Doppler variables were simultaneously recorded in 30 patients. PCWP was estimated by multilinear regression analysis using E and PV. The predictive accuracy of the equation obtained from the analysis was tested prospectively in a separate group of 65 patients divided into 3 groups: left ventricular (LV) systolic dysfunction (Group A), LV hypertrophy (Group B), and preserved systolic function without hypertrophy (Group C). The initial results obtained in groups B and C, respectively, were: r=0.77; r=0.81. These results indicate that a multilinear regression model based on E and PV is a noninvasive method of accurately estimating PCWP in a variety of cardiac disease states.
authors.affiliation: Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Seo
authors.forename: T
authors.initials: T
authors.lastname: Ishimitsu
authors.forename: N
authors.initials: N
authors.lastname: Moriyama
authors.forename: T
authors.initials: T
authors.lastname: Ishizu
authors.forename: T
authors.initials: T
authors.lastname: Enomoto
authors.forename: M
authors.initials: M
authors.lastname: Sakane
authors.forename: H
authors.initials: H
authors.lastname: Kamiya
authors.forename: Y
authors.initials: Y
authors.lastname: Hiranuma
authors.forename: I
authors.initials: I
authors.lastname: Yamaguchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D018618:Echocardiography, Doppler, Color / Q000379:methods* / Q000592:standards; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D012044:Regression Analysis; D015203:Reproducibility of Results; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000503:physiopathology