New access to 7,17-seco norditerpenoid alkaloids via reduction of the corresponding 8-chloro derivatives.
New access to the 7, 17-seco norditerpenoid alkaloids 9 (60%) from yunnaconitine (5), as well as 14 (46%) and 15 (22%) from isotalatizidine (10), via selective hydrolysis, chlorination and reduction with NaBH4 is described.
Wang
F P
FP
Department of Chemistry of Medicinal Natural Products, School of Pharmacy, West China University of Medical Sciences, Chengdu. wfp@wcums.edu.cn
Yang
J S
JS
Chen
Q H
QH
Yu
L
L
Li
B G
BG
D000157:Aconitine / Q000031:analogs & derivatives* / Q000737:chemistry*; D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006868:Hydrolysis; D010084:Oxidation-Reduction
D000700:Analgesics; D004365:Drugs, Chinese Herbal; C069835:yunaconitine; C423465:isotalatizidine; D000157:Aconitine