title: [A case of pseudo-Bartter's syndrome with marked nephrocarcinosis].
abstract: A 38-year-old woman was admitted to our hospital on October 21, 1996 for evaluation of thirst, bilateral backache and a feeling of abdominal fullness. She had hypokalemia, normotension, hyperreninemia, hyperaldostronism and hyperplasia of the juxtaglomerular apparatus on renal biopsy. Ultrasonography, intravenous pyelography and computed tomography showed marked bilateral renal calcification. Considering her history of persistent soft stool caused by chronic laxative abuse for 15 to 16 years and past diuretic abuse for several years since 1986, we diagnosed her as pseudo-Bartter's syndrome with nephrocarcinosis. The value of urinary Ca excretion was in the normal range, and acidification disturbance in NH4Cl loading test was revealed. In addition, she had taken analgesics for 2 to 3 years and interstitial nephritis on renal biopsy was seen. It is thus suggested that the cause of nephrocarcinosis in this case was the reduction of Ca solubility in the tubular cavity induced by incomplete renal tubular acidosis associated with analgesic nephropathy or interstitial nephritis caused by hypokalemia.
authors.affiliation: Department of Nephrology, Chiba Social Insurance Hospital, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Iesato
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Tsukahara
authors.forename: Y
authors.initials: Y
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Terano
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications; D000328:Adult; D000700:Analgesics / Q000009:adverse effects; D001477:Bartter Syndrome / Q000150:complications*; D002114:Calcinosis / Q000209:etiology*; D002400:Cathartics / Q000009:adverse effects; D004232:Diuretics / Q000009:adverse effects; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D009395:Nephritis, Interstitial / Q000150:complications; D019966:Substance-Related Disorders / Q000150:complications
chemical_list: D000700:Analgesics; D002400:Cathartics; D004232:Diuretics