title: Xerostomia, xerophthalmia, and plasmacytic infiltrates of the salivary glands (Sjögren's-like syndrome) in a cat.
abstract: A 2.5-year-old domestic shorthair cat was evaluated because of dysphagia and weight loss of 4 weeks' duration. MIld blepharospasm and conjunctival hyperemia were evident in both eyes, oral mucous membranes were tacky on palpation, and salivary glands were enlarged. Results of a Schirmer tear test were 0 mm/min for both eyes. Administration of atropine did not cause salivation or caused secretion fo thick rope-like saliva. Examination of biopsy specimens of salivary glands revealed a plasmacytic infiltrate. Sjögren's syndrome (SS) was diagnosed. Oral administration of prednisone was instituted but was discontinued after a minimal positive response was evident 6 weeks after initiation of treatment. Palliative treatment with a 6% solution of pilocarpine 4 to 5 times/d, cyclosporine, hylan A, and neomycin-polymyxin-bacitracin ophthalmic ointment resulted in clinical improvement in the cat. Although reported rarely in animals, SS may be more common than currently is recognized. Most treatment regimens for SS are aimed at alleviating clinical signs.
authors.affiliation: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
authors.forename: S O
authors.initials: SO
authors.lastname: Canapp
authors.forename: L A
authors.initials: LA
authors.lastname: Cohn
authors.forename: D J
authors.initials: DJ
authors.lastname: Maggs
authors.forename: M A
authors.initials: MA
authors.lastname: Miller
authors.forename: M E
authors.initials: ME
authors.lastname: Kerl
authors.forename: D P
authors.initials: DP
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001285:Atropine / Q000627:therapeutic use; D001706:Biopsy / Q000662:veterinary; D002371:Cat Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D002415:Cats; D002981:Clindamycin / Q000627:therapeutic use*; D003315:Cornea / Q000473:pathology; D003680:Deglutition Disorders / Q000662:veterinary; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D008916:Miotics / Q000627:therapeutic use; D009184:Mydriatics / Q000627:therapeutic use; D010862:Pilocarpine / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D012469:Salivary Glands / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D013666:Tears / Q000187:drug effects; D014743:Videotape Recording; D014985:Xerophthalmia / Q000662:veterinary; D014987:Xerostomia / Q000662:veterinary
chemical_list: D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D008916:Miotics; D009184:Mydriatics; D010862:Pilocarpine; D002981:Clindamycin; D001285:Atropine; D011241:Prednisone