Osteogenesis imperfecta: mode of delivery and neonatal outcome.
OBJECTIVE
To evaluate the pregnancy characteristics, methods of delivery, and neonatal outcomes of fetuses affected by osteogenesis imperfecta.


METHODS
We reviewed medical records of 1016 individuals whose cells were sent to the University of Washington Collagen Diagnostic Laboratory between 1987 and 1994 for confirmation of diagnoses of osteogenesis imperfecta. Information and neonatal records were available for 167 of those pregnancies. From those we identified method(s) of prenatal detection, delivery method, and neonatal complications, including survival and acquisition of new fractures, and related them to type of delivery.


RESULTS
The cesarean delivery rate was 54%, most of them (53%) for nonvertex presentation and fewer than 15% because of an antenatal diagnoses of osteogenesis imperfecta. There was an unusually high rate of breech presentation at term (37%). In infants with nonlethal forms of osteogenesis imperfecta, 24 of 59 (40%) delivered by cesarean and 17 of 53 (32%) delivered vaginally had new fractures (chi(2) =.89; P =.3). Among 55 infants with the most severe form, 24 of 31 delivered by cesarean and 21 of 24 delivered vaginally died within 2 weeks of birth.


CONCLUSIONS
Cesarean delivery did not decrease fracture rates at birth in infants with nonlethal forms of osteogenesis imperfecta nor did it prolong survival for those with lethal forms. Prenatal diagnosis did not influence mode of delivery in most instances. Most cesarean deliveries were done for usual obstetric indications.
Cubert
R
R
Department of Pathology, University of Washington, Seattle, Washington 98195, USA.
Cheng
E Y
EY
Mack
S
S
Pepin
M G
MG
Byers
P H
PH
D001946:Breech Presentation; D002585:Cesarean Section; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006801:Humans; D010013:Osteogenesis Imperfecta / Q000175:diagnosis; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis