Motor unit changes in inflammatory myopathy and progressive muscular dystrophy.
The aim of present study was to analyse the motor unit (MU) changes in progressive muscle dystrophy (PMD) and in inflammatory myopathy (IM) and to evaluate eventual neurogenic factors in MU reorganisation. The material consisted of 20 patients with (PMD), 20 patients with (IM) and 20 healthy age-matched volunteers. The shape of concentric needle motor unit potentials (cn MUPs), including their duration, amplitude, area, size index and number of phases, the interference pattern and the amplitude and area of macro MUPs were evaluated. The cn emg data satisfied the classical criteria for myopathy in all examined patients, at least in one of the tested muscles. A decreased amplitude and/or area of macro MUPs, compatible with myopathy, were observed in 32 of the 40 patients. In some cases of chronic IM and PDM the long duration polyphasic potentials were recorded. The size index (SI) value of long polyphasic MUPs was usually decreased or normal. This feature indicated that desynchronisation of "myopathic" MUPs results from a reduced number of muscle fibers and their degeneration and regeneration. The results indicated no difference in MU reorganization between PMD and IM and no evidence of neurogenic factors in MU changes.
Rowińska-Marcińska
K
K
Department of Neurology, Medical University of Warsaw, 1a Banach St., 02-097 Warsaw, Poland.
Szmidt-Sałkowska
E
E
Kopeć
A
A
Wawro
A
A
Karwańska
A
A
D000200:Action Potentials / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004576:Electromyography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000503:physiopathology*; D009136:Muscular Dystrophies / Q000503:physiopathology*; D009220:Myositis / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology