title: Littoral cell angioma associated with portal hypertension and resected colon cancer.
abstract: Littoral cell angioma (LCA) is a rare vascular tumor of the spleen with an unknown etiology and unclear natural history. An association with synchronous malignancy has been described. We report the case of a 54-year-old woman who had progressive splenomegaly over 3 years following resection of a colon adenocarcinoma. The splenomegaly was associated with portal hypertension and severe thrombocytopenia. Splenectomy was performed, and the histologic and immunocytochemical features of the spleen specimen were consistent with LCA. The relationship between LCA and malignancy is reviewed.
authors.affiliation: Division of Hematology, Department of Internal Medicine Mayo Clinic, Rochester, Minn 55905, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: Steensma
authors.forename: W G
authors.initials: WG
authors.lastname: Morice
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D003110:Colonic Neoplasms / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D006391:Hemangioma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis* / Q000473:pathology; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000473:pathology; D013163:Splenomegaly