title: The role of personality, coping style and social support in health-related quality of life in HIV infection.
abstract: OBJECTIVE
  To determine the role of health status, personality and coping style, on self-report health-related quality of life (QoL).
  
  
  METHODS
  Participants were HIV seropositive individuals at all disease stages from three samples (a) gay/bisexual men from the UK, (b) injecting drug users from the UK, (c) injecting drug users from Italy. All participants completed questionnaires evaluating QoL, personality, coping style and social support. Explicit models of the relationships between the measured variables based on a review of the literature were tested using structural equation modelling.
  
  
  RESULTS
  Health status was modestly associated with the physical but not the psychological aspects of QoL (beta = 0.44). Neuroticism was strongly associated with psychological QoL (beta = -0.73) but only weakly with physical QoL (beta = -0.21). The samples did not differ in either the pattern or the magnitude of these relationships. Mediating factors such as coping style, social support and other personality variables had only a weak influence on the role of Neuroticism.
  
  
  CONCLUSIONS
  Neuroticism had a strong influence on health-related QoL that was independent of health status. Neuroticism was more strongly associated with the psychological aspects of QoL than health status. Coping styles and the other psychological variables assessed had only a weak mediating influence on this relationship.
authors.affiliation: Division of Neuroscience and Psychological Medicine, Imperial College of Science, Technology & Medicine, London, UK. a.burgess@ic.ac.uk
authors.forename: A P
authors.initials: AP
authors.lastname: Burgess
authors.forename: M
authors.initials: M
authors.lastname: Carretero
authors.forename: A
authors.initials: A
authors.lastname: Elkington
authors.forename: E
authors.initials: E
authors.lastname: Pasqual-Marsettin
authors.forename: C
authors.initials: C
authors.lastname: Lobaccaro
authors.forename: J
authors.initials: J
authors.lastname: Catalán
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000523:psychology; D006304:Health Status; D006801:Humans; D007558:Italy; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D010551:Personality; D011788:Quality of Life; D012944:Social Support; D006113:United Kingdom