A comparison of the effect of nitroparacetamol and paracetamol on liver injury.
Paracetamol (5 mmol kg(-1), i.p.) caused liver damage in rats as indicated by increased plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and glutamate dehydrogenase (GDH) activities. No change in plasma bilirubin or creatinine was noted. An equimolar dose of nitroparacetamol (a nitric oxide (NO)-releasing derivative of paracetamol) did not alter plasma levels of any of the markers of liver/kidney damage. No difference in plasma or liver paracetamol was apparent in animals injected with paracetamol or nitroparacetamol. These results indicate that NO released from nitroparacetamol exhibits hepatoprotective activity in these animals and suggest that nitroparacetamol may therefore be considered as a safer alternative to paracetamol in the clinic.
Futter
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LE
Messengers & Signalling Research Group, Cardiovascular Research Centre, School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, London SE1 9RT.
al-Swayeh
O A
OA
Moore
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PK
D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism* / Q000503:physiopathology; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D009566:Nitrates / Q000097:blood / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000633:toxicity*; D009573:Nitrites / Q000097:blood / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; D015415:Biomarkers; D009566:Nitrates; D020030:Nitric Oxide Donors; D009573:Nitrites; D000082:Acetaminophen