Wnt signaling: an embarrassment of receptors.
Recent genetic studies in Drosophila and mouse have uncovered a new aspect of the Wnt signal transduction machinery. Mutations disrupting LDL-receptor related proteins produce loss-of-function Wnt phenotypes, suggesting that these cell surface molecules may represent essential co-receptors for Wnt ligands.
Bejsovec
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Department of Biology, Duke University, B336 LSRC Box 91000, Durham, North Carolina 27708, USA. bejsovec@duke.edu
D000818:Animals; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008934:Mitogens / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009024:Morphogenesis / Q000235:genetics*; D011509:Proteoglycans / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D029721:Drosophila Proteins; D051157:Frizzled Receptors; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D008934:Mitogens; D011509:Proteoglycans; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled; D011973:Receptors, LDL; D051153:Wnt Proteins; D029961:Zebrafish Proteins; C098128:dally protein, Drosophila; C058784:fz protein, Drosophila