title: Bilateral cystosarcoma phyllodes of the breast: a case report of malignant form with contralateral benign form.
abstract: Bilateral cystosarcoma phyllode is uncommon; bilateral tumors, either synchronous or metachronous, are generally either benign or malignant. We report one case of bilateral synchronous cystosarcoma phyllode in a 32-year-old pregnant woman. The left breast mass, measuring 21 x 17 x 10 cm, was classified as malignant cystosarcoma phyllode (high cellularity, stromal overgrowth, marked nuclear atypia, necrosis, mitotic rate = 4 mitoses/10 high power field, infiltrative margin). The right 9 x 9 cm mass was a benign cystosarcoma phyllode tumor (low to moderate cellularity, discrete nuclear atypia, mitotic rate = 1 mitoses/10 high power field, no necrosis, pushing margin). The patient had a left-sided mastectomy and a complete local excision with clear margin of the right breast mass. The patient is free of disease with a 17-month follow-up.
authors.affiliation: Department of Pathology. Salah Azaiez Institute, Tunis, Tunisia.
authors.forename: K
authors.initials: K
authors.lastname: Mrad
authors.forename: M
authors.initials: M
authors.lastname: Driss
authors.forename: M
authors.initials: M
authors.lastname: Maalej
authors.forename: K B
authors.initials: KB
authors.lastname: Romdhane
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D003557:Phyllodes Tumor / Q000473:pathology* / Q000601:surgery; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000601:surgery