title: Synthesis and activity of selective MMP inhibitors with an aryl backbone.
abstract: A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.
authors.affiliation: Pharmacia, Department of Medicinal Chemistry, Skokie, IL 60077, USA. barta@netmug.org
authors.forename: T E
authors.initials: TE
authors.lastname: Barta
authors.forename: D P
authors.initials: DP
authors.lastname: Becker
authors.forename: L J
authors.initials: LJ
authors.lastname: Bedell
authors.forename: G A
authors.initials: GA
authors.lastname: De Crescenzo
authors.forename: J J
authors.initials: JJ
authors.lastname: McDonald
authors.forename: G E
authors.initials: GE
authors.lastname: Munie
authors.forename: S
authors.initials: S
authors.lastname: Rao
authors.forename: H S
authors.initials: HS
authors.lastname: Shieh
authors.forename: R
authors.initials: R
authors.lastname: Stegeman
authors.forename: A M
authors.initials: AM
authors.lastname: Stevens
authors.forename: C I
authors.initials: CI
authors.lastname: Villamil
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D017364:Collagenases / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D020781:Matrix Metalloproteinase 1 / Q000737:chemistry / Q000378:metabolism; D053509:Matrix Metalloproteinase 13; D020778:Matrix Metalloproteinase 2 / Q000737:chemistry / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D017364:Collagenases; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; D020778:Matrix Metalloproteinase 2; D020781:Matrix Metalloproteinase 1