title: Comparison of the outcome and treatment of psychosis in people of Caribbean origin living in the UK and British Whites. Report from the UK700 trial.
abstract: BACKGROUND
  The comparative outcome of psychosis in British Whites and UK African-Caribbeans is unclear. Some report that African-Caribbeans have worse outcome, whereas others claim better symptomatic outcome and a more benign course.
  
  
  OBJECTIVE
  To compare the course, outcome and treatment of psychosis in African-Caribbeans and British Whites in a large multi-centre sample.
  
  
  METHODS
  A secondary analysis of 708 patients with research diagnostic criteria-defined psychosis from a 2-year, randomised controlled trial of case management. Outcome measures (hospitalisation, illness course, self-harm, social disability and treatment received) were adjusted for socio-economic and clinical differences between groups at baseline using regression analysis.
  
  
  RESULTS
  African-Caribbeans were less likely to have a continuous illness and to receive treatment with antidepressant or psychotherapy.
  
  
  CONCLUSIONS
  The outcome of psychosis is complex but differs between UK African-Caribbeans and British Whites. This may reflect risk factors that increase the rate of psychosis in UK African-Caribbeans. Treatment differences require further investigation.
authors.affiliation: Haringey Healthcare Trust and University Department of Psychiatry, Royal Free and University College Medical Schools, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UK.
authors.forename: K
authors.initials: K
authors.lastname: McKenzie
authors.forename: C
authors.initials: C
authors.lastname: Samele
authors.forename: E
authors.initials: E
authors.lastname: Van Horn
authors.forename: T
authors.initials: T
authors.lastname: Tattan
authors.forename: J
authors.initials: J
authors.lastname: Van Os
authors.forename: R
authors.initials: R
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017691:Caribbean Region / Q000208:ethnology; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011618:Psychotic Disorders / Q000208:ethnology* / Q000628:therapy; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology; D044465:White People