title: Use of amifostine as a chemoprotectant during high-dose chemotherapy in autologous peripheral blood stem cell transplantation.
abstract: This report describes two patients with germ cell tumors who underwent tandem autologous peripheral stem cell transplants. The chemotherapy consisted of high-dose carboplatin and etoposide. Both patients developed chemotherapy-related toxicities, which included nephrotoxicity in one case and febrile neutropenia, thrombocytopenia, ototoxicity and mucositis in both. During the second transplant, both patients received amifostine 15 min before and 2 h after each dose of carboplatin. The patients had less mucositis and nephrotoxicity. The duration of neutropenia and thrombocytopenia was less in both cases resulting in a decreased use of antibiotics and platelet transfusions. These cases suggest that the use of amifostine may be of benefit in minimizing toxicities associated with high-dose chemotherapy.
authors.affiliation: Blood and Marrow Stem Cell Transplantation Program, College of Pharmacy, University of Michigan Medical Center, Ann Arbor, USA.
authors.forename: S
authors.initials: S
authors.lastname: Cronin
authors.forename: J P
authors.initials: JP
authors.lastname: Uberti
authors.forename: L J
authors.initials: LJ
authors.lastname: Ayash
authors.forename: C
authors.initials: C
authors.lastname: Raith
authors.forename: V
authors.initials: V
authors.lastname: Ratanatharathorn
mesh_terms: D000328:Adult; D004999:Amifostine / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D018237:Germinoma / Q000188:drug therapy / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000628:therapy*; D019172:Transplantation Conditioning
chemical_list: D001761:Bleomycin; D005047:Etoposide; D016190:Carboplatin; D004999:Amifostine; D002945:Cisplatin