Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers.
Gemifloxacin and trovafloxacin were administered to 12 volunteers in a randomized crossover trial with a 2-week washout period. Stool samples were collected predose and 1, 2, and 3 days postdose. Both quinolones reduced the number of organisms of the family Enterobacteriaceae and aerobic gram-positive organisms. Escherichia coli reduction was greater with gemifloxacin than with trovafloxacin, with postdose isolation of quinolone-resistant strains for which MICs of trovafloxacin were higher than those of gemifloxacin.
Garcia-Calvo
G
G
Department of Medical Microbiology, Fundación Jiménez Díaz, Madrid, Spain.
Molleja
A
A
Giménez
M J
MJ
Parra
A
A
Nieto
E
E
Ponte
C
C
Aguilar
L
L
Soriano
F
F
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D004926:Escherichia coli / Q000187:drug effects; D005243:Feces / Q000382:microbiology*; D024841:Fluoroquinolones; D000077735:Gemifloxacin; D006801:Humans; D009287:Naphthyridines / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin; D000077735:Gemifloxacin