title: Synthesis and in vitro cytotoxic evaluation of N-substituted benzo[5,6]cycloheptal[b]indoles.
abstract: A new series of V-substituted benzo[5,6]cyclohepta[b]indole derivatives were synthesised and evaluated for in vitro cytotoxic activities against L1210 murine leukemia and HT29 cell lines. Among them, several compounds showed potent antitumor activity and blocked cell cycle progression of L1210 cells in G2+M phase.
authors.affiliation: Institut de Chimie Organique et Analytique, associé au CNRS, Université d'Orléans, France.
authors.forename: B
authors.initials: B
authors.lastname: Joseph
authors.forename: D
authors.initials: D
authors.lastname: Alagille
authors.forename: J Y
authors.initials: JY
authors.lastname: Mérour
authors.forename: S
authors.initials: S
authors.lastname: Léonce
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D003508:Cycloheptanes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D019073:HT29 Cells; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007939:Leukemia L1210; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D003508:Cycloheptanes; D007211:Indoles