title: 4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
authors.affiliation: Departments of Medicinal Chemistry, Molecular Systems, and Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. john_wai@merck.com
authors.forename: J S
authors.initials: JS
authors.lastname: Wai
authors.forename: M S
authors.initials: MS
authors.lastname: Egbertson
authors.forename: L S
authors.initials: LS
authors.lastname: Payne
authors.forename: T E
authors.initials: TE
authors.lastname: Fisher
authors.forename: M W
authors.initials: MW
authors.lastname: Embrey
authors.forename: L O
authors.initials: LO
authors.lastname: Tran
authors.forename: J Y
authors.initials: JY
authors.lastname: Melamed
authors.forename: H M
authors.initials: HM
authors.lastname: Langford
authors.forename: J P
authors.initials: JP
authors.lastname: Guare
authors.forename: L
authors.initials: L
authors.lastname: Zhuang
authors.forename: V E
authors.initials: VE
authors.lastname: Grey
authors.forename: J P
authors.initials: JP
authors.lastname: Vacca
authors.forename: M K
authors.initials: MK
authors.lastname: Holloway
authors.forename: A M
authors.initials: AM
authors.lastname: Naylor-Olsen
authors.forename: D J
authors.initials: DJ
authors.lastname: Hazuda
authors.forename: P J
authors.initials: PJ
authors.lastname: Felock
authors.forename: A L
authors.initials: AL
authors.lastname: Wolfe
authors.forename: K A
authors.initials: KA
authors.lastname: Stillmock
authors.forename: W A
authors.initials: WA
authors.lastname: Schleif
authors.forename: L J
authors.initials: LJ
authors.lastname: Gabryelski
authors.forename: S D
authors.initials: SD
authors.lastname: Young
mesh_terms: D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006678:HIV; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D002087:Butyrates; D019428:HIV Integrase Inhibitors