Effect of center- versus patient-specific factors on variations in dialysis adequacy.
Efforts to improve the delivery of hemodialysis have focused mostly on identifying patient-related factors that lead to inadequate dialysis. Less consideration has been given to the impact of the dialysis center on adequacy. This study evaluated whether the dialysis facility or individual-level factors were the primary influence on variations in dialysis adequacy. This was a retrospective analysis of 4971 hemodialysis patients in 189 centers with urea reduction ratio (URR) values obtained in the final quarter of 1997. The between-center variation and the within-center correlation in URR values were quantified to determine the contribution of a center effect on variations in adequacy; furthermore, the proportion of variance attributable to the centers' effect and individual-level dialysis covariates were compared. There was a wider between-center variation in mean URR values (SD, 4.8%) than expected if there were no center effect (SD, 2.5%). There was a strong within-center correlation in URR values, measured by the parameter rho, which was only minimally diminished after adjusting for individual-level covariates (adjusted rho, 0.14; P < 0.0001). The variation in URR attributable to the center effect, quantified by R(2), was greater than that related to individual-level dialysis factors (facility- and individual-level dialysis covariates R(2), 23.6 and 11.3%, respectively). Initiatives to improve the delivery of dialysis in patients with end-stage renal disease should be directed at facility policies governing dialysis care, along with patient-specific problems, because center effects have a major influence on dialysis adequacy.
Fink
Jeffrey C
JC
The Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Blahut
Steven A
SA
The Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Briglia
Andrew E
AE
The Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Gardner
James F
JF
The Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Light
Paul D
PD
The Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011787:Quality of Health Care; D012041:Regional Medical Programs / Q000592:standards / Q000706:statistics & numerical data; D006435:Renal Dialysis / Q000379:methods / Q000592:standards* / Q000706:statistics & numerical data; D012189:Retrospective Studies; D014481:United States; D014508:Urea / Q000378:metabolism
D014508:Urea