MR imaging of pulmonary and mediastinal malignancies.
The primary goal of performing cross-sectional imaging of the chest in the radiologic evaluation of lung cancer is to obtain information about the character and magnitude of the neoplasm. Patient prognosis and therapy decisions depend directly on identifying the size and full extent of the tumor. The ideal imaging modality therefore should provide reliable information that can be used to assist in accurately staging the malignancy. Traditionally, CT scanning has been used exclusively as part of the preoperative evaluation of primary lung carcinomas. Recent advances in CT scanning technology have greatly improved image acquisition times and image quality and consequently have enhanced the role of CT imaging in the evaluation of bronchogenic carcinomas. Single-breath CT acquisitions of the chest can now be accomplished in a matter of seconds. These rapid acquisitions improve image quality by decreasing respiratory motion, while enhancing patient compliance and throughput. Clearly, CT scanning has matured into an efficient and accurate diagnostic tool to stage primary lung malignancies noninvasively. In its present state of development, MR imaging has one distinct disadvantage that makes it significantly less attractive as a routine lung cancer examination, namely the inability to produce images of the lung that are high in spatial resolution. Also, the sensitivity and specificity of MR imaging, which are similar to those of CT scanning in identifying mediastinal and hilar metastases, offer no clinical advantages. Longer image acquisition times and time constraints force most MR imaging examinations to be abbreviated and limited in coverage. As a result, the necessary exclusion of important anatomic areas routinely visualized by CT scanning may limit the diagnostic power of MR imaging. Finally, MR imaging requires greater physician supervision than CT scanning to direct imaging and to maintain examination quality and thoroughness. Although MR imaging can contribute significantly to the radiologic evaluation of patients with lung cancer, its role is somewhat limited, and it is most useful as a complement to CT scanning. The additional versatility offered by pulse sequences that take advantage of the intrinsic relaxation of tissues greatly facilitates identification of tumor, particularly when local invasion is present. By virtue of the short T1 value of fat, MR imaging may improve the detection of mediastinal disease, particularly in cases in which the sensitivity of CT scanning cannot be optimized because of allergies to contrast or renal insufficiency. MR imaging is superior to CT scanning in demonstrating musculoskeletal anatomy and the neurovascular structures of the neck and mediastinum. Although MR imaging has a potential usefulness in the radiographic evaluation of lung carcinoma, technical shortcomings relegate this modality to a role that is primarily complementary to CT scanning. With time, technological improvements will undoubtedly redefine the role of MR imaging in the radiographic evaluation and staging of bronchogenic carcinomas.
Thompson
B H
BH
Department of Radiology, The University of Iowa College of Medicine, Iowa City, USA.
Stanford
W
W
D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009361:Neoplasm Invasiveness; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis / Q000473:pathology; D013899:Thoracic Neoplasms / Q000473:pathology