title: Distortion product otoacoustic emission suppression in subjects with auditory neuropathy.
abstract: OBJECTIVE
  The objective of this experiment was to address: 1) whether normal efferent system function is required for normal cochlear tuning as measured by distortion product otoacoustic emission (DPOAE) suppression in humans and 2) whether cochlear function, assessed by DPOAE suppression tuning, is normal in a small group of patients with auditory neuropathy.
  
  
  METHODS
  DPOAE suppression tuning curves (STCs) are similar to other physiologic measures of tuning. They are generated by evoking a DPOAE with two simultaneously presented pure tones and then suppressing the distortion product with a third tone of varying frequency and level. In this study, DPOAE STCs were generated with f2 frequencies of 1500, 3000, and 6000 Hz in 15 normal-hearing adults and four subjects with documented auditory neuropathy. Tuning curve width, slope and tip characteristics, as well as rate of suppression growth were measured in each group. Contralateral suppression of otoacoustic emissions (OAEs) was also recorded as an index of medial efferent function.
  
  
  RESULTS
  Results show that the four subjects with auditory neuropathy lacked efferent suppression of OAEs. However, these four subjects showed normal estimates of cochlear tuning as measured by DPOAE suppression results.
  
  
  CONCLUSIONS
  This finding suggests that normal efferent system function is not required at the time of test for normal DPOAE suppression tuning. It also suggests that cochlear function as evaluated by detailed measures of DPOAE suppression, is normal in these "typical" patients with auditory neuropathy.
authors.affiliation: Children's Auditory Research and Evaluation Center, House Ear Institute, Los Angeles, California 90057, USA.
authors.forename: C
authors.initials: C
authors.lastname: Abdala
authors.forename: Y S
authors.initials: YS
authors.lastname: Sininger
authors.forename: A
authors.initials: A
authors.lastname: Starr
mesh_terms: D000328:Adult; D002648:Child; D003051:Cochlea / Q000503:physiopathology*; D003056:Cochlear Nerve / Q000503:physiopathology*; D004525:Efferent Pathways / Q000503:physiopathology; D006801:Humans; D017084:Otoacoustic Emissions, Spontaneous; D000160:Vestibulocochlear Nerve Diseases / Q000503:physiopathology*