title: CD30+ anaplastic large-cell lymphoma with aberrant expression of CD13: case report and review of the literature.
abstract: CD13 is commonly expressed in hematopoietic malignancies of myelomonocytic origin and has less commonly been described in lymphoid neoplasms, including acute lymphoblastic leukemia, B-cell lymphoproliferative disorders, and plasma cell malignancies. Aberrant CD13 expression has rarely been described in KP-1 (CD68)-positive large-cell lymphomas. However, CD13 positivity has not previously been described in a case of CD30+ (ALK-1+) anaplastic large-cell lymphoma of presumed null-cell origin without histiocytic differentiation. The purpose of this case report is to describe a CD30+ anaplastic large-cell lymphoma of presumed null-cell origin with aberrant expression of CD13. The case illustrates the unique usefulness of immunophenotypic and molecular techniques in establishing the correct diagnosis. The case was referred with a diagnosis of "rule out granulocytic sarcoma versus megakaryocytic malignancy" due to the morphology and a limited flow cytometric immunophenotypic (FCI) panel that had been performed and revealed expression of CD45, HLA-DR, and CD13. Subsequent morphologic review at our institution combined with an expanded FCI panel established the diagnosis. The differential diagnosis of a CD13+ hematopoietic malignancy should include this entity. The prognostic significance of this finding has yet to be determined.
authors.affiliation: Department of Pathology, St. Louis University Health Science Center, Missouri 63104, USA. dunphyc@slucare1.sluh.edu
authors.forename: C H
authors.initials: CH
authors.lastname: Dunphy
authors.forename: L J
authors.initials: LJ
authors.lastname: Gardner
authors.forename: J L
authors.initials: JL
authors.lastname: Manes
authors.forename: C S
authors.initials: CS
authors.lastname: Bee
authors.forename: K
authors.initials: K
authors.lastname: Taysi
mesh_terms: D000293:Adolescent; D018826:CD13 Antigens / Q000032:analysis*; D002466:Cell Nucleolus / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002869:Chromosome Aberrations; D003593:Cytoplasm / Q000473:pathology; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D017730:Ki-1 Antigen / Q000032:analysis*; D017493:Leukocyte Common Antigens / Q000032:analysis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008297:Male; D008938:Mitosis
chemical_list: D006684:HLA-DR Antigens; D017730:Ki-1 Antigen; D017493:Leukocyte Common Antigens; D018826:CD13 Antigens