Substituted 1,6-naphthyridines as human cytomegalovirus inhibitors: conformational requirements.
Substituted 1,6-naphthyridine derivatives, a new class of human cytomegalovirus inhibitors, were prepared to demonstrate the role of intramolecular hydrogen bonds to maintain the compounds in their active conformation.
Falardeau
G
G
BioChem Pharma Inc., Laval, Québec, Canada.
Chan
L
L
Stefanac
T
T
May
S
S
Jin
H
H
Lavallée
J F
JF
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D009287:Naphthyridines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D009287:Naphthyridines