title: Functional localisation in the cerebral cortex and cerebellum: lessons from the past.
abstract: One of the basic questions about the working of the brain is the extent to which its various functions are localised. In the nineteenth century great advances were made in the study of localisation. The control of speech, movement, and vision was identified with specific regions of the cerebral cortex. Although since the nineteenth century lesions of the cerebellum have been known to produce impaired movement, there has been rather little progress towards answering more detailed questions about the functions of the cerebellum and cerebellar localisation. The experts are still not agreed on what the cerebellum does or how and where it does it. Three examples are given of functions which probably are mediated by the cerebellum; adaptation of the vestibulo-ocular reflex, classical conditioning of the nictitating membrane response, and adaptation of saccadic eye movements. In all three cases the control of these functions has been localised to a specific region of the cerebellar cortex and/or nuclei. The success of localisation studies in the cerebral cortex can serve as a guide. Continued experimentation directed at the question of localisation should prove a fruitful approach to understanding more about the functions of the cerebellum.
authors.affiliation: Department of Anatomy, University College London, London, Great Britain, United Kingdom. m.glickstein@ucl.ac.uk
authors.forename: M
authors.initials: M
authors.lastname: Glickstein
mesh_terms: D000715:Anatomy / Q000266:history*; D000818:Animals; D001931:Brain Mapping; D002531:Cerebellum / Q000033:anatomy & histology* / Q000502:physiology; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology; D005060:Europe; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans