Hyponatremia secondary to reset osmostat in a child with a central nervous system midline defect and a chromosomal abnormality.
A newborn with a CNS midline defect and persistent hyponatremia was diagnosed with a "reset" osmostat using a 3% hypertonic saline test. The diagnosis was established by measuring urinary arginine vasopressin (UAVP) and plasma osmolality (P(Osmoil)). In this infant a chromosome abnormality with the karyotype 46, X, -X, +der(X) t(X;13) (p22.1;q22) was associated with the midline defect and a reset osmostat.
Gupta
P
P
Department of Pediatrics, University of Illinois, College of Medicine, Peoria, USA.
Mick
G
G
Fong
C T
CT
Jospe
N
N
McCormick
K
K
D001127:Arginine Vasopressin / Q000378:metabolism* / Q000652:urine; D001769:Blood / Q000378:metabolism; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D007231:Infant, Newborn; D007621:Karyotyping; D009994:Osmolar Concentration; D012462:Saline Solution, Hypertonic; D014960:X Chromosome / Q000235:genetics
D012462:Saline Solution, Hypertonic; D001127:Arginine Vasopressin