title: Advanced generation adenoviral vectors possess augmented gene transfer efficiency based upon coxsackie adenovirus receptor-independent cellular entry capacity.
abstract: Adenoviral (Ad) vectors have been widely used in the context of cancer gene therapy approaches. Their utility in these contexts, however, has frequently been limited by tumor cell resistance to Ad infection. The basis of this resistance has been defined recently as resulting from a deficiency of the primary adenovirus receptor, coxsackie adenovirus receptor. As a means to circumvent this limitation, a variety of tropism modification strategies have allowed coxsackie adenovirus receptor-independent gene delivery via the Ad vector. These advanced generation adenovirus vectors exhibit enhanced infectivity, which can allow direct therapeutic gain. Such vectors may allow improvements in efficacy in the context of ongoing human clinical gene therapy approaches for cancer.
authors.affiliation: Department of Medicine, Gene Therapy Center, The University of Alabama at Birmingham, 35294-3300, USA.
authors.forename: V
authors.initials: V
authors.lastname: Krasnykh
authors.forename: I
authors.initials: I
authors.lastname: Dmitriev
authors.forename: J G
authors.initials: JG
authors.lastname: Navarro
authors.forename: N
authors.initials: N
authors.lastname: Belousova
authors.forename: E
authors.initials: E
authors.lastname: Kashentseva
authors.forename: J
authors.initials: J
authors.lastname: Xiang
authors.forename: J T
authors.initials: JT
authors.lastname: Douglas
authors.forename: D T
authors.initials: DT
authors.lastname: Curiel
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D004770:Enterovirus / Q000235:genetics*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D009369:Neoplasms / Q000628:therapy*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011991:Receptors, Virus / Q000235:genetics
chemical_list: D008024:Ligands; D011991:Receptors, Virus; C085301:adenovirus receptor