title: Genomic exploration of the hemiascomycetous yeasts: 4. The genome of Saccharomyces cerevisiae revisited.
abstract: Since its completion more than 4 years ago, the sequence of Saccharomyces cerevisiae has been extensively used and studied. The original sequence has received a few corrections, and the identification of genes has been completed, thanks in particular to transcriptome analyses and to specialized studies on introns, tRNA genes, transposons or multigene families. In order to undertake the extensive comparative sequence analysis of this program, we have entirely revisited the S. cerevisiae sequence using the same criteria for all 16 chromosomes and taking into account publicly available annotations for genes and elements that cannot be predicted. Comparison with the other yeast species of this program indicates the existence of 50 novel genes in segments previously considered as 'intergenic' and suggests extensions for 26 of the previously annotated genes.
authors.affiliation: Unité de Génétique Moléculaire des Levures (URA 2171 CNRS and UFR 927 Univ. P.M. Curie), Institut Pasteur, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Blandin
authors.forename: P
authors.initials: P
authors.lastname: Durrens
authors.forename: F
authors.initials: F
authors.lastname: Tekaia
authors.forename: M
authors.initials: M
authors.lastname: Aigle
authors.forename: M
authors.initials: M
authors.lastname: Bolotin-Fukuhara
authors.forename: E
authors.initials: E
authors.lastname: Bon
authors.forename: S
authors.initials: S
authors.lastname: Casarégola
authors.forename: J
authors.initials: J
authors.lastname: de Montigny
authors.forename: C
authors.initials: C
authors.lastname: Gaillardin
authors.forename: A
authors.initials: A
authors.lastname: Lépingle
authors.forename: B
authors.initials: B
authors.lastname: Llorente
authors.forename: A
authors.initials: A
authors.lastname: Malpertuy
authors.forename: C
authors.initials: C
authors.lastname: Neuvéglise
authors.forename: O
authors.initials: O
authors.lastname: Ozier-Kalogeropoulos
authors.forename: A
authors.initials: A
authors.lastname: Perrin
authors.forename: S
authors.initials: S
authors.lastname: Potier
authors.forename: J
authors.initials: J
authors.lastname: Souciet
authors.forename: E
authors.initials: E
authors.lastname: Talla
authors.forename: C
authors.initials: C
authors.lastname: Toffano-Nioche
authors.forename: M
authors.initials: M
authors.lastname: Wésolowski-Louvel
authors.forename: C
authors.initials: C
authors.lastname: Marck
authors.forename: B
authors.initials: B
authors.lastname: Dujon
mesh_terms: D001203:Ascomycota / Q000235:genetics; D015825:Chromosomes, Fungal; D021901:DNA, Intergenic; D005800:Genes, Fungal; D016681:Genome, Fungal; D005810:Multigene Family; D016366:Open Reading Frames; D012343:RNA, Transfer / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods
chemical_list: D021901:DNA, Intergenic; D012343:RNA, Transfer