Gene function.
The problem of gene function--of the relationships between hereditary material and the characteristics of organisms--preceded the rediscovery of Mendel's laws and accompanied the development of genetics in the XXth century. Molecular biologists replaced the simple gene-character relationship by two relationships: the first, between genes and proteins, was well defined, whereas the second between proteins and the complex structural and functional characteristics of organisms remained unknown. I will describe in this article the experimental approaches which helped to characterize during the last twenty years the relationships between proteins and characters. Four principles of macromolecular organization emerged from these studies: conservation of the elementary components during evolution, existence of pathways and networks, pleiotropy and redundancy. These principles are the explanation of the surprising experimental observations that have been made in recent years. The existence of these principles makes problematic any prediction on the consequences of gene modification. It both sounds the death-knell of the simplistic reductionist approach of many biologists, whereby genes were considered as responsible for specific functions, and definitely prevents the distribution of genes in separate, well defined categories.
Morange
M
M
Département de biologie, Ecole normale supérieure, 46, rue d'Ulm, 75230 Paris cedex 05, France. morange@wotan.ens.fr
D000818:Animals; D005823:Genetics / Q000266:history* / Q000639:trends; D005826:Genetics, Medical / Q000266:history / Q000639:trends; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008967:Molecular Biology / Q000266:history* / Q000639:trends; D010684:Philosophy; D011506:Proteins / Q000235:genetics
D011506:Proteins