Impaired prostate tumorigenesis in Egr1-deficient mice.
The transcription factor early growth response protein 1 (EGR1) is overexpressed in a majority of human prostate cancers and is implicated in the regulation of several genes important for prostate tumor progression. Here we have assessed the effect of Egr1 deficiency on tumor development in two transgenic mouse models of prostate cancer (CR2-T-Ag and TRAMP). Using a combination of high-resolution magnetic resonance imaging and histopathological and survival analyses, we show that tumor progression was significantly impaired in Egr1-/- mice. Tumor initiation and tumor growth rate were not affected by the lack of Egr1; however, Egr1 deficiency significantly delayed the progression from prostatic intra-epithelial neoplasia to invasive carcinoma. These results indicate a unique role for Egr1 in regulating the transition from localized, carcinoma in situ to invasive carcinoma.
Abdulkadir
S A
SA
Department of Pathology, Washington University, Box 8118, 660 S Euclid Avenue, St. Louis, Missouri 63119, USA.
Qu
Z
Z
Garabedian
E
E
Song
S K
SK
Peters
T J
TJ
Svaren
J
J
Carbone
J M
JM
Naughton
C K
CK
Catalona
W J
WJ
Ackerman
J J
JJ
Gordon
J I
JI
Humphrey
P A
PA
Milbrandt
J
J
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D051766:Early Growth Response Protein 1; D015972:Gene Expression Regulation, Neoplastic; D017874:Immediate-Early Proteins; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009363:Neoplasm Proteins; D011230:Precancerous Conditions / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics*; D012097:Repressor Proteins / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D051766:Early Growth Response Protein 1; C486109:Egr1 protein, mouse; D017874:Immediate-Early Proteins; C491000:NAB2 protein, human; C099945:Nab2 protein, mouse; D009363:Neoplasm Proteins; D012097:Repressor Proteins; D014157:Transcription Factors