Growth hormone deficiency caused by pituitary stalk interruption in Fanconi's anemia.
Fanconi's anemia can be associated with growth retardation. We describe biologic growth hormone deficiency, isolated or associated with thyrotropin abnormality, and pituitary stalk interruption syndrome on magnetic resonance imaging of 5 patients with Fanconi's anemia. Growth hormone treatment produced catch-up growth in all cases. These findings suggest a common genetic origin.
Dupuis-Girod
S
S
Pediatric Endocrinology and Immuno-Hematology Departments, Physiology Laboratory, Université René Descartes and Hôpital Necker-Enfants Malades, Paris, France.
Gluckman
E
E
Souberbielle
J C
JC
Brauner
R
R
D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005199:Fanconi Anemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006130:Growth Disorders / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D007986:Luteinizing Hormone / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D010902:Pituitary Gland / Q000002:abnormalities*; D011388:Prolactin / Q000097:blood; D012189:Retrospective Studies; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome
D019382:Human Growth Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013974:Thyroxine; D006854:Hydrocortisone