title: Hydroxychloroquine-induced seizure in a patient with systemic lupus erythematosus.
abstract: We report on a case of a 17-year-old female with systemic lupus erythematosus (SLE), with a clinical history of complex partial seizure, who developed a tonicoclonic crisis after receiving hydroxychloroquine for 2 weeks at a dosage of 200 mg/day (5 mg/kg). The absence of previous similar episodes and of recurrences after withdrawal of the drug in subsequent months, the short latency after administration and the favourable short-term evolution raised suspicions for a potential role of the drug in the development of the isolated convulsive crisis. It is possible for hydroxychloroquine to be responsible for tonicoclonic seizures in predisposed subjects.
authors.affiliation: Istituto di Clinica Medica, Ematologia ed Immunologia Clinica, Università di Ancona, Polo Didattico Scientifico, Torrette di Ancona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Malcangi
authors.forename: P
authors.initials: P
authors.lastname: Fraticelli
authors.forename: C
authors.initials: C
authors.lastname: Palmieri
authors.forename: M
authors.initials: M
authors.lastname: Cappelli
authors.forename: M G
authors.initials: MG
authors.lastname: Danieli
mesh_terms: D000293:Adolescent; D018501:Antirheumatic Agents / Q000009:adverse effects*; D000075202:Contraindications; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D012640:Seizures / Q000139:chemically induced*
chemical_list: D018501:Antirheumatic Agents; D006886:Hydroxychloroquine