title: Radiosurgery for malignant meningioma: results in 22 patients.
abstract: OBJECTIVE
  The initial treatment of malignant meningiomas in the past has included surgical removal followed by fractionated external-beam radiotherapy. Radiosurgery has been added to the options for treatment of primary or recurrent tumors over the last 10 years. The authors report their results of using gamma knife radiosurgery (GKS) to treat 22 patients over an 8-year period.
  
  
  METHODS
  Twenty-two patients who underwent GKS for malignant meningioma between December 1991 and May 1999 were evaluated. Three patients were treated with GKS as a boost to radiotherapy and 19 for recurrence following radiotherapy. Outcome factors including patient survival, freedom from progression, and complications were analyzed. In addition, in the recurrent group, variables such as patient age, sex, tumor location, target volume, margin dose, and maximum dose were also analyzed. Univariate and multivariate analyses were performed. Overall 5-year survival and progression-free survival estimates were 40% and 26%, respectively. Age (p < or = 0.003) and tumor volume (p < or = 0.05) were significant predictors of time to progression and survival in both univariate and multivariate analyses. Five patients (23%) developed radiation necrosis. Significant relationships between complications and treatment variables or patient characteristics could not be established.
  
  
  CONCLUSIONS
  Tumor control following GKS is greater in patients with smaller-sized tumors (< 8 cm3) and in younger patients. Gamma knife radiosurgery can be performed to treat malignant meningioma with acceptable toxicity. The efficacy of GKS relative to other therapies for recurrent malignant meningioma as well as the value of GKS as a boost to radiotherapy will require further evaluation.
authors.affiliation: Department of Neurological Surgery, University of California, San Francisco 94143, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Ojemann
authors.forename: P K
authors.initials: PK
authors.lastname: Sneed
authors.forename: D A
authors.initials: DA
authors.lastname: Larson
authors.forename: P H
authors.initials: PH
authors.lastname: Gutin
authors.forename: M S
authors.initials: MS
authors.lastname: Berger
authors.forename: L
authors.initials: L
authors.lastname: Verhey
authors.forename: V
authors.initials: V
authors.lastname: Smith
authors.forename: P
authors.initials: P
authors.lastname: Petti
authors.forename: W
authors.initials: W
authors.lastname: Wara
authors.forename: E
authors.initials: E
authors.lastname: Park
authors.forename: M W
authors.initials: MW
authors.lastname: McDermott
mesh_terms: D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D008579:Meningioma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D011183:Postoperative Complications / Q000175:diagnosis / Q000401:mortality; D016634:Radiosurgery; D012189:Retrospective Studies; D015996:Survival Rate