Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.
Ohmoto
K
K
Gonex, Inc., Colorado State University, ARBL, Ft. Collins, Colorado 80523-1683, USA.
Yamamoto
T
T
Horiuchi
T
T
Imanishi
H
H
Odagaki
Y
Y
Kawabata
K
K
Sekioka
T
T
Hirota
Y
Y
Matsuoka
S
S
Nakai
H
H
Toda
M
M
Cheronis
J C
JC
Spruce
L W
LW
Gyorkos
A
A
Wieczorek
M
M
D000284:Administration, Oral; D000818:Animals; D018360:Crystallography, X-Ray; D004285:Dogs; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000882:Haplorhini; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; C419152:ONO 6818; D010069:Oxadiazoles; D011744:Pyrimidinones; D019272:Leukocyte Elastase