title: Tyrosine kinase A, autonomic and transmitter receptors, but not innervation, are upregulated in the aging rat prostate.
abstract: In the mature rat ventral prostate, epithelial proliferation is accompanied by significant upregulation of tyrosine kinase A, alpha1B and muscarinic acetylcholine M2 receptors as well as the synaptic vesicle-associated membrane proteins synaptobrevin and SV2 as compared with immature prostate tissue. The adrenergic receptors beta1, alpha2A and alpha1 were also up-regulated and translocated in mature rat prostate tissue. Expression of the Schwann cell/axonal marker S100 remained unchanged. These results are suggestive of a marked increase in metabolic activity, calcium influx and autonomic receptor expression in the aging prostate. These changes were not accompanied by an increase in the number of axons.
authors.affiliation: Institute for Biomedical Research and Department of Anatomy and Histology, The University of Sydney, NSW, Australia. michaels@anatomy.usyd.edu.au
authors.forename: M
authors.initials: M
authors.lastname: Slater
authors.forename: J A
authors.initials: JA
authors.lastname: Barden
authors.forename: C R
authors.initials: CR
authors.lastname: Murphy
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011467:Prostate / Q000294:innervation* / Q000378:metabolism*; D050683:R-SNARE Proteins; D051381:Rats; D017208:Rats, Wistar; D043585:Receptor, Muscarinic M2; D020917:Receptor, trkA / Q000378:metabolism*; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D015854:Up-Regulation
chemical_list: C547718:Adra1b protein, rat; D015220:Calcium Channels; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D050683:R-SNARE Proteins; D043585:Receptor, Muscarinic M2; D018340:Receptors, Adrenergic, alpha-1; D011976:Receptors, Muscarinic; D009418:S100 Proteins; C489618:Sv2a protein, rat; D020917:Receptor, trkA