[High-dose thiotepa chemotherapy in children].
High-dose thiotepa (800-900 mg/m2) polychemotherapy following combined treatment resulted in high toxicity and lethality. 600 mg/m2 proved optimal for double-conditioning regimens since it exerted antitumor effect without causing fatal complications.
Izhogin
D G
DG
N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
Boiarshinov
V K
VK
Dolgonolov
I S
IS
Iankelevich
M Ia
MIa
Ptushkina
E A
EA
Mentkevich
G L
GL
D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D016019:Survival Analysis; D013852:Thiotepa / Q000008:administration & dosage* / Q000009:adverse effects*; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000188:drug therapy*
D018906:Antineoplastic Agents, Alkylating; D013852:Thiotepa