Effects of intravenous infusion of guaifenesin on electroencephalographic variables in pigs.
OBJECTIVE
To investigate the sedative effects of guaifenesin in pigs by use of electroencephalography.


METHODS
10 Norwegian Landrace pigs (5 castrated males and 5 sexually intact females).


METHODS
Guaifenesin (150 mg/kg of body weight, IV) was administered during a 5-minute period. Using a 2-channel referential electrode configuration, electroencephalograms were recorded before, during, and after infusion of guaifenesin. Changes in spectral edge frequency 95% (SEF), median frequency (MED), and total power were evaluated.


RESULTS
After administration of guaifenesin, SEF decreased significantly, and total power increased significantly; however, MED did not change significantly. Analysis of the data did not reveal differences between pigs on the basis of sex.


CONCLUSIONS
We concluded that guaifenesin synchronized the patterns of electroencephalograms. This is a strong indication that the drug has a sedative effect in pigs.
Haga
H A
HA
Department of Large Animal Clinical Science, The Norwegian School of Veterinary Science, Oslo, Norway.
Moerch
H
H
Soli
N E
NE
D000818:Animals; D004569:Electroencephalography / Q000187:drug effects / Q000662:veterinary*; D005260:Female; D006140:Guaifenesin / Q000008:administration & dosage / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D009919:Orchiectomy; D012016:Reference Values; D013552:Swine; D013997:Time Factors
D006140:Guaifenesin