Cytotoxicity of extractives from Taiwania cryptomerioides heartwood.
The cytotoxicity of the dominant lignans and sesquiterpenoids from Taiwania (Taiwania cryptomerioides Hayata) was investigated. Three human tumor cells including A-549 lung carcinoma. MCF-7 breast adenocarcinoma and HT-29 colon adenocarcinoma were selected to illustrate the structure-cytotoxicity relationships of Taiwania's dominant compounds. Taiwanin A, taiwanin E and dimethylmatairesinol exhibited significant cytotoxicity against three human tumor cells. Among them, taiwanin A possesses the strongest cytotoxic activity. In addition, the morphology-based evaluation, flow cytometric analysis, and DNA fragmentation assays demonstrated that the tumor cell death induced by taiwanin A was due to apoptosis.
Chang
S T
ST
Department of Forestry, National Taiwan University, Taipei. peter@ms.cc.ntu.edu.tw
Wang
D S
DS
Wu
C L
CL
Shiah
S G
SG
Kuo
Y H
YH
Chang
C J
CJ
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D032462:Cycadopsida / Q000737:chemistry*; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D017705:Lignans; D010936:Plant Extracts; C419332:taiwanin A