title: HLA-B*0811: another example of a single point substitution of the HLA-B*0801 allele.
abstract: The described alle HLA-B*0811 is of Caucasoid origin. Most likely it derived from a point mutation of the B*0801 allele at position 559, where an adenine was converted to guanine. This position corresponds to codon 163 and resulted in an amino acid change from threonine to alanine. This substitution may influence both, T-cell interactions and/or peptide binding.
authors.affiliation: Department of Pediatrics, University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia, USA.
authors.forename: E
authors.initials: E
authors.lastname: Magira
authors.forename: B
authors.initials: B
authors.lastname: Beznik-Cizman
authors.forename: D
authors.initials: D
authors.lastname: Monos
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D018076:DNA, Complementary; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D018076:DNA, Complementary; D015235:HLA-B Antigens