Measurements for assessing environmental exposures to children using small amounts of serum and urine: state-of-the-art.
This paper addresses the recent advances in gas chromatographic (GC)-based instrumentation for the analytical determination of environmental toxicants using small samples. One-dimensional GC/time-of-flight mass spectrometry (TOFMS) and comprehensive two-dimensional GC (GCxGC) are shown to drastically improve sample component resolution, sensitivity and overall analytical throughput. A presentation of the concepts behind the new state-of-the-art, and results highlighting the advantages of the emerging technologies are presented.
Dimandja
J M
JM
Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Toxicology Branch, Atlanta, Georgia 30341, USA.
Grainger
J
J
Patterson
D G
DG
Turner
W E
WE
Needham
L L
LL
D002648:Child; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000032:analysis* / Q000097:blood / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D010573:Pesticide Residues / Q000032:analysis / Q000097:blood / Q000652:urine; D012680:Sensitivity and Specificity
D004785:Environmental Pollutants; D010573:Pesticide Residues