Synthesis and theoretical study of 2-amino-2,3,3a,4,5,6-hexahydro-1H-phenalene and its biological evaluation on central dopaminergic system.
Compound 2 considered as a rigid non-hydroxylated 2-amino tetralin was synthesized and biologically evaluated. Central administration of compound 2 (50 microg or 100 microg/10 microl) induced a reduction in urinary sodium and potassium excretion at 3 and 6 h of urine collection. We speculate that compound 2 may be acting as a dopamine receptor antagonist.
Angel-Guío
J E
JE
Laboratorio de Síntesis Orgánica y Diseño Molecular, Departamento de Química, Facultad Experimental de Ciencias, Universidad del Zulia, Maracaibo, Venezuela. jangel@luz.ve
Charris
J E
JE
Pérez
J
J
Duerto de Pérez
Z D
ZD
Compagnone
R
R
Israel
A
A
Orfila
L
L
Migliore de Angel
B
B
López
S E
SE
Rodríguez
L
L
Caldera
J
J
Michelena de Báez
E
E
Arrieta
F
F
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D018492:Dopamine Antagonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009318:Natriuresis / Q000187:drug effects; D043803:Phenalenes; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors*; D012964:Sodium / Q000652:urine
C430450:2-amino-2,3,3a,4,5,6-hexahydro-1H-phenalene; D000588:Amines; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D006571:Heterocyclic Compounds; D043803:Phenalenes; D011083:Polycyclic Compounds; D017447:Receptors, Dopamine D1; D012964:Sodium; D011188:Potassium