The effects of antidepressants on sleep in patients with depression.
This paper reviews sleep disturbances in patients with major depressive disorders and the effects of different classes of antidepressants on sleep. It is clear from the studies reviewed that not all antidepressants improve sleep, and, indeed, some worsen sleep disturbances in patients with depression. Whether sleep is improved or further disrupted is of high clinical significance, because persistent sleep problems elevate the risk of relapse, recurrence, or suicide, as well as the need for augmenting medications.
Armitage
R
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Sleep Study Unit, University of Texas Southwestern Medical Center at Dallas, Texas 75390-9070, USA. Roseanne.Armitage@UTSouthwestern.edu
D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D012894:Sleep Stages / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000139:chemically induced* / Q000175:diagnosis
D000928:Antidepressive Agents