title: 6-(hydroxyalkyl)penicillanates as probes for mechanisms of beta-lactamases.
abstract: 6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of beta-lactamases, enzymes of resistance for beta-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of beta-lactamases.
authors.affiliation: Department of Chemistry and Institute for Drug Design, Wayne State University, Detroit, MI 48202-3489, USA.
authors.forename: D
authors.initials: D
authors.lastname: Golemi
authors.forename: L
authors.initials: L
authors.lastname: Maveyraud
authors.forename: A
authors.initials: A
authors.lastname: Ishiwata
authors.forename: S
authors.initials: S
authors.lastname: Tranier
authors.forename: K
authors.initials: K
authors.lastname: Miyashita
authors.forename: T
authors.initials: T
authors.lastname: Nagase
authors.forename: I
authors.initials: I
authors.lastname: Massova
authors.forename: L
authors.initials: L
authors.lastname: Mourey
authors.forename: J P
authors.initials: JP
authors.lastname: Samama
authors.forename: S
authors.initials: S
authors.lastname: Mobashery
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015335:Molecular Probes; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013379:Substrate Specificity; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; D015335:Molecular Probes; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D001618:beta-Lactamases