Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7.
We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides. 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test, was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced CIN, indicating that E7-specific T-helper cells have a role in control of HPV.
Höpfl
R
R
Heim
K
K
Christensen
N
N
Zumbach
K
K
Wieland
U
U
Volgger
B
B
Widschwendter
A
A
Haimbuchner
S
S
Müller-Holzner
E
E
Pawlita
M
M
Pfister
H
H
Fritsch
P
P
D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000821:virology; D008297:Male; D009856:Oncogene Proteins, Viral / Q000276:immunology*; D027383:Papillomaviridae / Q000276:immunology; D050725:Papillomavirus E7 Proteins; D030361:Papillomavirus Infections / Q000276:immunology; D012075:Remission, Spontaneous; D012882:Skin Tests; D014412:Tumor Virus Infections / Q000276:immunology; D002578:Uterine Cervical Dysplasia / Q000276:immunology* / Q000821:virology
D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; C059731:oncogene protein E7, Human papillomavirus type 16