title: Effect of dofetilide on the pharmacokinetics of digoxin.
abstract: The effect of dofetilide on the steady-state pharmacokinetics of digoxin was evaluated in a randomized, double-blind study. Five days of dofetilide treatment did not significantly affect steady-state pharmacokinetic variables of digoxin compared with placebo; therefore, the use of dofetilide does not necessitate an adjustment in digoxin dose to maintain therapeutic digoxin levels.
authors.affiliation: Pfizer Clinical Research Unit, H pital Erasme, Brussels, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Kleinermans
authors.forename: D J
authors.initials: DJ
authors.lastname: Nichols
authors.forename: I
authors.initials: I
authors.lastname: Dalrymple
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004077:Digoxin / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010627:Phenethylamines / Q000097:blood / Q000494:pharmacology*; D013449:Sulfonamides / Q000097:blood / Q000494:pharmacology*
chemical_list: D000889:Anti-Arrhythmia Agents; D010627:Phenethylamines; D013449:Sulfonamides; D004077:Digoxin; C063533:dofetilide