title: Management of gestational trophoblastic diseases: subsequent pregnancy experience.
abstract: Patients with gestational trophoblastic disease (GTD) can usually achieve complete sustained remission while retaining their fertility even in the presence of wide-spread metastasis. Following complete and partial mole, our patients had 1,239 and 205 later pregnancies, respectively, which resulted in 68.6% and 74.1% term live births, respectively. Patients with either type of hydatidiform mole have, in general, a normal later pregnancy experience. After one molar pregnancy, the risk of a molar pregnancy in a later conception was about 1%. Our patients who received chemotherapy for persistent gestational trophoblastic tumor had 522 later pregnancies, which resulted in 358 (68.6%) term live births and only 10 (2.5%) major and minor congenital anomalies. Data from other centers involving 2,598 later pregnancies also indicate that after chemotherapy patients can generally anticipate a normal future reproductive outcome.
authors.affiliation: New England Trophoblastic Disease Center, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Berkowitz
authors.forename: Z S
authors.initials: ZS
authors.lastname: Tuncer
authors.forename: M R
authors.initials: MR
authors.lastname: Bernstein
authors.forename: D P
authors.initials: DP
authors.lastname: Goldstein
mesh_terms: D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D014328:Trophoblastic Neoplasms / Q000453:epidemiology / Q000628:therapy; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000628:therapy