title: The diagnostic value of streptococcal serology in early arthritis: a prospective cohort study.
abstract: OBJECTIVE
  To evaluate the diagnostic value of streptococcal serology in adult early arthritis patients in discriminating between post-streptococcal reactive arthritis (PSRA) and arthritis with other causes.
  
  
  METHODS
  The antistreptolysin-O (ASO) and anti-DNase B tests were performed at baseline in 366 consecutive, newly referred early arthritis patients. After 1 yr of follow-up the patients were classified according to international classification criteria and were evaluated for the presence of persistent arthritis. The outcome measures were the predictive value of streptococcal serology for the diagnosis of PSRA and the ability of this serology to discriminate at the first visit between the self-limiting and persistent forms of arthritis.
  
  
  RESULTS
  With a positive serological result, the probability of having PSRA increased from 2 to 9%, whereas the probabilities of having rheumatoid arthritis or undifferentiated arthritis continued to be high (23 and 29%). The serological tests did not discriminate between the self-limiting and persistent forms of arthritis. The major Jones criteria apart from arthritis were not observed.
  
  
  CONCLUSIONS
  Streptococcal serology has no diagnostic value in adult early arthritis patients in whom major Jones criteria other than arthritis are not present.
authors.affiliation: Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Visser
authors.forename: I
authors.initials: I
authors.lastname: Speyer
authors.forename: B
authors.initials: B
authors.lastname: Ozcan
authors.forename: F C
authors.initials: FC
authors.lastname: Breedveld
authors.forename: M L
authors.initials: ML
authors.lastname: van Ogtrop
authors.forename: J M
authors.initials: JM
authors.lastname: Hazes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000989:Antistreptolysin / Q000032:analysis; D001168:Arthritis / Q000175:diagnosis* / Q000382:microbiology; D001170:Arthritis, Infectious / Q000175:diagnosis* / Q000382:microbiology; D003851:Deoxyribonucleases / Q000032:analysis / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013291:Streptococcus / Q000276:immunology
chemical_list: D000989:Antistreptolysin; D003851:Deoxyribonucleases; C020069:deoxyribonuclease B