title: A new inhibitor of 5'-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, from Trichoderma hamatum.
abstract: Screening for inhibitors of 5'-hydroxyaverantin dehydrogenase, an enzyme involved in aflatoxin biosynthesis, resulted in the isolation of a new metabolite (1) from Trichoderma hamatum. On the basis of spectroscopic data, 1 was determined to be 4, 6-dihydroxy-5-methoxy-6a-methylcyclohexa[de]indano[7, 6-e]cyclopenta[c]2H-pyran-1,9-dione.
authors.affiliation: Department of Agricultural Chemistry, Faculty of Agriculture, Tottori University, Koyama, Tottori 680-8553, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Sakuno
authors.forename: K
authors.initials: K
authors.lastname: Yabe
authors.forename: T
authors.initials: T
authors.lastname: Hamasaki
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
mesh_terms: D000348:Aflatoxins / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007658:Ketone Oxidoreductases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014242:Trichoderma / Q000737:chemistry*
chemical_list: C421045:4, 6-dihydroxy-5-methoxy-6a-methylcyclohexa(de)indano(7, 6-e)cyclopenta(c)2H-pyran-1,9-dione; D000348:Aflatoxins; D004791:Enzyme Inhibitors; D011714:Pyrans; C421044:5'-hydroxyaverantin dehydrogenase; D007658:Ketone Oxidoreductases