[Comparison of cytogenic response of human lymphocytes to in vivo and in vitro exposure to low doses of gamma-rays. Unstable chromosomal exchanges detected by FPG techniques].
On peripheral lymphocytes of eight cancer patients undergone whole-body therapeutic irradiation (at daily dose of 10 cGy up to total dose of 50 cGy of 60Co gamma-rays) the dose-response of unstable chromosome exchanges (dicentrics and centric rings) was studied. This dose response fitted well linear function. The lower slope of dose-response curve was found for in vivo irradiated lymphocytes as compared to the dose response curve obtained for in vitro irradiated lymphocytes of the same patients. This finding seems to provide evidence that in case of protracted irradiation of individuals an absorbed dose could be underestimated if for biological dosimetry an in vitro dose response curve for unstable chromosome aberrations is used as referent one.
Vorontsova
I E
IE
Central Research Institute of Roentgenology and Radiology, Ministry of Health of Russia, St. Petersburg, 197758 Russia. radgen@gate.la.spb.ru
Semenov
A V
AV
Kanaeva
A Iu
AIu
Timofeeva
N M
NM
Iakovleva
T K
TK
Zharinov
G M
GM
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations / Q000235:genetics*; D003434:Crossing Over, Genetic / Q000235:genetics / Q000528:radiation effects*; D004260:DNA Repair / Q000528:radiation effects; D004273:DNA, Neoplasm / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008214:Lymphocytes / Q000473:pathology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D008938:Mitosis / Q000235:genetics / Q000528:radiation effects; D009369:Neoplasms / Q000097:blood / Q000235:genetics / Q000473:pathology / Q000532:radiotherapy
D004273:DNA, Neoplasm