Roles of urokinase type plasminogen activator in a brain stab wound.
Urokinase type plasminogen activator (uPA) may influence brain pathophysiology after injury. We studied disruption of the blood-brain barrier (BBB) and changes in the vasculature after a brain stab wound in uPA-deficient, uPA receptor-deficient, and PA inhibitor-1 (PAI-1) deficient mice. The extravasation of immunoglobulin was greater in PAI-1 deficient mice; less pronounced in uPA-deficient mice; similar to controls in uPA receptor-deficient mice. Vasculatures in the wound proliferated in PAI-1 deficient mice. Our study shows that uPA affects BBB disruption. PA enhances angiogenesis after brain injury.
Kataoka
K
K
Department of Neurosurgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, 589-8511, Osaka, Japan. kataoka@med.kindai.ac.jp
Asai
T
T
Taneda
M
M
Ueshima
S
S
Matsuo
O
O
Kuroda
R
R
Kawabata
A
A
Carmeliet
P
P
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D003094:Collagen / Q000378:metabolism*; D005260:Female; D020197:Head Injuries, Penetrating / Q000378:metabolism*; D007136:Immunoglobulins / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D017395:Plasminogen Activator Inhibitor 1 / Q000172:deficiency / Q000378:metabolism*; D014568:Urokinase-Type Plasminogen Activator / Q000172:deficiency / Q000378:metabolism*; D014951:Wounds, Stab / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism*
D007136:Immunoglobulins; D017395:Plasminogen Activator Inhibitor 1; D014841:von Willebrand Factor; D003094:Collagen; D014568:Urokinase-Type Plasminogen Activator