title: Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder.
abstract: The insertion/deletion polymorphism of the gene of angiotensin-converting enzyme (ACE) was investigated in a case-control study including 169 patients with suffering from either bipolar disorder type I or unipolar recurrent major depression (DSM-IV) and 169 healthy controls. No significant association was found with bipolar disorder type I or unipolar recurrent depression and the polymorphism of the ACE gene. A previously reported genetic association (Arinami et al., 1996) was not confirmed by the present study.
authors.affiliation: Department of Psychiatry, University of Göttingen, Federal Republic of Germany. jpauls@gwdg.de
authors.forename: J
authors.initials: J
authors.lastname: Pauls
authors.forename: B
authors.initials: B
authors.lastname: Bandelow
authors.forename: E
authors.initials: E
authors.lastname: Rüther
authors.forename: J
authors.initials: J
authors.lastname: Kornhuber
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D004251:DNA Transposable Elements; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A