title: Enantioselective Michael addition of nitromethane to alpha, beta-enones catalyzed by chiral quaternary ammonium salts. A simple synthesis of (R)-baclofen.
abstract: [reaction:see text] Enantioselective Michael addition of nitromethane to an alpha, beta-enone is a key step in the synthesis of (R)-baclofen.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. corey@chemistry.harvard.edu
authors.forename: E J
authors.initials: EJ
authors.lastname: Corey
authors.forename: F Y
authors.initials: FY
authors.lastname: Zhang
mesh_terms: D001418:Baclofen / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012492:Salts; D013237:Stereoisomerism
chemical_list: D000644:Quaternary Ammonium Compounds; D012492:Salts; D001418:Baclofen