Synthesis of macrolide analogues of sanglifehrin by RCM: unique reactivity of a ruthenium carbene complex bearing an imidazol-2-ylidene ligand. Ring-closing metathesis.
Wagner
J
J
Novartis Pharma AG, S-350.207, CH-4002 Basel, Switzerland. juergen.wagner@pharma.novartis.com
Martin Cabrejas
L M
LM
Grossmith
C E
CE
Papageorgiou
C
C
Senia
F
F
Wagner
D
D
France
J
J
Nolan
S P
SP
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry; D008024:Ligands; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D013058:Mass Spectrometry; D012428:Ruthenium; D013141:Spiro Compounds / Q000737:chemistry; D013302:Streptomyces / Q000737:chemistry
D000900:Anti-Bacterial Agents; D007093:Imidazoles; D007166:Immunosuppressive Agents; D007783:Lactones; D008024:Ligands; D018942:Macrolides; D013141:Spiro Compounds; C121329:sanglifehrin A; D012428:Ruthenium