title: Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.
abstract: Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in humans. In contrast, the physiologic role of arginase II has not been defined, and no deficiencies in arginase II have been identified in humans. Mice with a disruption in the arginase II gene were created to investigate the role of this enzyme. Homozygous arginase II-deficient mice were viable and apparently indistinguishable from wild-type mice, except for an elevated plasma arginine level which indicates that arginase II plays an important role in arginine homeostasis.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: O
authors.initials: O
authors.lastname: Shi
authors.forename: S M
authors.initials: SM
authors.lastname: Morris
authors.forename: H
authors.initials: H
authors.lastname: Zoghbi
authors.forename: C W
authors.initials: CW
authors.lastname: Porter
authors.forename: W E
authors.initials: WE
authors.lastname: O'Brien
mesh_terms: D000596:Amino Acids / Q000097:blood; D000818:Animals; D001119:Arginase / Q000235:genetics* / Q000502:physiology; D001120:Arginine / Q000097:blood; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D018390:Gene Targeting; D006801:Humans; D020162:Hyperargininemia; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D010641:Phenotype; D011073:Polyamines / Q000378:metabolism
chemical_list: D000596:Amino Acids; D017931:DNA Primers; D011073:Polyamines; D001120:Arginine; D001119:Arginase