title: A single sub-anaesthetic dose of propofol to reduce patient recall of peribulbar block.
abstract: We audited a total of 1233 patients scheduled for elective cataract extraction or trabeculectomy using peri-bulbar anaesthesia. A bolus of propofol provided sedation to cover insertion of the block. During an initial two-year period we collected data on the amount of propofol used to sedate 481 patients. Multiple linear regression analysis was then used to obtain an equation to link the dose used to age and weight in those who were adequately sedated. The dose of propofol in milligrams was calculated as 56 + 0.25 x weight (kg) - 0.53 x age (yrs). We subsequently assessed the effectiveness of this formula at abolishing recall of the injections whilst not compromising the airway on a further 752 patients. This simple regime was effective at abolishing recall of the block in 78.6% of the patients studied and avoids the cost and logistic implications of more complicated drug delivery systems. Use of the formula does not significantly alter the incidence of recall compared to sedation provided by an experienced ophthalmic anaesthetist. We hope it will provide a guide for more junior anaesthetists to obtain the satisfactory sedation level that comes with experience.
authors.affiliation: Department of Anaesthesia, MDHU Frimley Park Hospital, Frimley, Camberley, Surrey, GU16 5UJ. drghocking@hotmail.com
authors.forename: G
authors.initials: G
authors.lastname: Hocking
authors.forename: H G
authors.initials: HG
authors.lastname: Balmer
mesh_terms: D000367:Age Factors; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology; D000779:Anesthetics, Local; D001835:Body Weight; D002045:Bupivacaine; D002387:Cataract Extraction / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000494:pharmacology; D007275:Injections, Intravenous; D008012:Lidocaine; D016014:Linear Models; D008297:Male; D008485:Medical Audit; D011939:Mental Recall / Q000187:drug effects*; D009407:Nerve Block / Q000379:methods*; D015742:Propofol / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D012727:Sex Characteristics; D014130:Trabeculectomy / Q000009:adverse effects*
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D006993:Hypnotics and Sedatives; D008012:Lidocaine; D002045:Bupivacaine; D015742:Propofol