Determination of the relative and absolute stereochemistry of a potent and alpha1A-selective adrenoceptor antagonist.
The binding affinities and selectivities of antagonists 1-4 for the alpha1A-adrenoceptor are dependent on the stereochemical orientation of the groups at the C-4 and C-5 positions of the oxazolidinone ring. The unambiguous assignment of the relative and absolute configurations of the diastereomers of SNAP 7915 (1) is reported.
Lagu
B
B
Department of Chemistry, Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA. blagu@prius.jnj.com
Wetzel
J M
JM
Forray
C
C
Patane
M A
MA
Bock
M G
MG
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010080:Oxazoles / Q000737:chemistry; D013237:Stereoisomerism
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D010080:Oxazoles; C412726:SNAP 7915