Age-dependent chemosensitive pontine inhibition of medullary respiratory rhythm generation in the isolated brainstem of the neonatal rat.
Age-dependence and chemosensitivity of the pontine inhibitory effect on medullary respiratory rhythm generation were examined in the isolated brainstem-spinal cord of the neonatal rat. In early preparations (days 1-2), the increase in RR (Delta RR) induced by the pons resection was larger in 8% CO(2) (pH 7.2) than in 2% CO(2) (pH 7.8). That difference was not found in late preparations (days 3-4). Under a given pH, the Delta RR was larger in early preparations than in late preparations.
Ito
Y
Y
Department of Medicine, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
Oyamada
Y
Y
Yamaguchi
K
K
D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001933:Brain Stem / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D002245:Carbon Dioxide / Q000494:pharmacology; D066298:In Vitro Techniques; D008526:Medulla Oblongata / Q000254:growth & development / Q000502:physiology; D011149:Pons / Q000254:growth & development / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015656:Respiratory Mechanics / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*
D002245:Carbon Dioxide