Cytotoxic cembrenolides and steroids from the formosan soft coral Sarcophyton crassocaule.
Three new cytotoxic cembrenolide diterpenes, sarcocrassolide (1), crassolide (2), and 13-acetoxysarcocrassolide (3); a known cytotoxic cembrenolide, denticulatolide (4); and two cytotoxic steroids, (24S)-24-methylcholestane-3beta,5alpha,6beta-triol (5) and 24zeta-methylcholestane-3beta,5alpha,6beta,25-te traol-25-monoacetate (6), have been isolated from the Formosan soft coral Sarcophyton crassocaule. The structures of compounds 1-6 were determined by 1D and 2D spectral analysis.
Duh
C Y
CY
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Wang
S K
SK
Chung
S G
SG
Chou
G C
GC
Dai
C F
CF
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
C421030:24-methylcholestane-3,5,6,25-tetraol-25-monoacetate; C421029:24-methylcholestane-3,5,6-triol; D000970:Antineoplastic Agents; D004224:Diterpenes