title: Stroke severity determines body temperature in acute stroke.
abstract: OBJECTIVE
  Several studies have claimed that temperature on admission is of prognostic significance in acute stroke. Experimental studies showing that hyperthermia increases infarct size have lent credibility to this assumption. The aim of the present study was to test the hypothesis that initial body temperature is of importance for stroke outcome.
  
  
  METHODS
  This prospective study included 725 consecutive patients, 584 with cerebral infarcts and 141 with intracerebral hemorrhages, admitted to an acute stroke unit within 6 hours of stroke onset. Time of stroke onset and time of admission were recorded. Body temperature was measured on admission and every 2 hours during the first 24 hours. Patients were divided into 2 groups on the basis of stroke severity on admission: Scandinavian Stroke Scale Score (SSS) </=25 was defined as major stroke, and SSS >25 was defined as mild to moderate stroke.
  
  
  RESULTS
  On admission, mean body temperature was normal. In the major stroke patients, body temperature started to rise 4 to 6 hours after stroke onset. At 10 to 12 hours after stroke onset, increased body temperature was found to be related to poor outcome. In mild to moderate stroke, there was no significant rise in temperature. Initial temperature >37.5 degrees C was not related to stroke severity or stroke outcome.
  
  
  CONCLUSIONS
  In major stroke, a significant rise in temperature occurred hours after stroke onset. Severe infarcts and intracerebral hemorrhages caused temperature to rise, whereas initially increased temperature had no influence on stroke severity. Elevated body temperature on admission within 6 hours of stroke onset had no prognostic influence on stroke outcome at 3 months.
authors.affiliation: Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. gb01@bbh.hosp.dk
authors.forename: G
authors.initials: G
authors.lastname: Boysen
authors.forename: H
authors.initials: H
authors.lastname: Christensen
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D001831:Body Temperature; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D002544:Cerebral Infarction / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D005334:Fever / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D000082:Acetaminophen