Oxidative deamination of benzylamine by electrogenerated quinonoid systems as mimics of amine oxidoreductases cofactors.
The reactions of a new type of quinonoid system with benzylamine have been investigated in methanol in order to mimic the reactions occurring in the course of the enzymatic oxidation of amines by quinone cofactors. Under strictly anaerobic conditions, unstable quinonoid species 1(ox)()-4(ox)() have been selectively electrogenerated using anodic-controlled potential electrolysis. Thus, we have demonstrated that 3,4-quinone 1(ox)() is incapable of deaminating benzylamine, while 3,4-iminoquinone species 3(ox)() and 4(ox)() act as efficient catalysts for the autorecycling oxidation of benzylamine: the reaction efficiency reached 64 turnovers. Additional mechanistic investigations reveal that the oxidation of benzylamine by our quinonoid model cofactors proceeds unambiguously via a transamination mechanism, as suggested for many enzymatic systems.
Largeron
M
M
Laboratoire de Chimie Analytique et Electrochimie, UMR 8638 CNRS - Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75270 Paris Cedex 06, France.
Fleury
M B
MB
D001596:Benzylamines / Q000737:chemistry*; D003641:Deamination; D004563:Electrochemistry; D007202:Indicators and Reagents; D008628:Mercury; D010084:Oxidation-Reduction; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000737:chemistry*; D011809:Quinones / Q000138:chemical synthesis*
D001596:Benzylamines; D007202:Indicators and Reagents; D011809:Quinones; D000587:Oxidoreductases Acting on CH-NH Group Donors; D008628:Mercury