4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
Wai
J S
JS
Departments of Medicinal Chemistry, Molecular Systems, and Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. john_wai@merck.com
Egbertson
M S
MS
Payne
L S
LS
Fisher
T E
TE
Embrey
M W
MW
Tran
L O
LO
Melamed
J Y
JY
Langford
H M
HM
Guare
J P
JP
Zhuang
L
L
Grey
V E
VE
Vacca
J P
JP
Holloway
M K
MK
Naylor-Olsen
A M
AM
Hazuda
D J
DJ
Felock
P J
PJ
Wolfe
A L
AL
Stillmock
K A
KA
Schleif
W A
WA
Gabryelski
L J
LJ
Young
S D
SD
D002087:Butyrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D006678:HIV; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
D002087:Butyrates; D019428:HIV Integrase Inhibitors