[Experimental comparative study of the anti-inflammatory effectiveness of pranoprofen].
OBJECTIVE
To study the antiinflammatory capacity of topical pranoprofen in comparison with other ophthalmological nonsteroidal antiinflammatory drugs (diclofenac and flurbiprofen) in albino rabbits.


METHODS
We have produced an endotoxin-induced uveitis by intravitreal injection of 10 ng of Salmonella typhimurium endotoxin. We have used 48 albino rabbits (4 groups of 12 animals each), first group were control group (intravitreal saline solution), which were treated unilaterally every two hours with 2 drops of: Group II, pranoprofen (1 mg/ml). Group III, diclofenac (0.2 mg/ml). Group IV, flurbiprofen (0.3 mg/ml). We determined clinical signs of inflammation and protein concentration in the aqueous humor. The rabbits were sacrificed 24 hours after the endotoxin administration.


RESULTS
In all treated groups we observed a significant reduction (p<0.05) in all studied parameter as compared with control group, except for ciliar hyperemia. Different treatment groups did not show differences.


CONCLUSIONS
The antiinflammatory capacity of pranoprofen is comparable to other NSAIDs derived from propionic acid such as flurbiprofen, obtaining a good control of endotoxin-induced uveitis.
Andrés
R C
RC
Servicio de Oftalmología, Hospital Miguel Servet, Po. Isabel la Católica, 1-3, 50009 Zaragoza, Spain.
Moreno
O R
OR
Marín Del Tiempo
D
D
Aragués
A R
AR
Llorens
V P
VP
Gonzalvo
F
F
López
F H
FH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001578:Benzopyrans / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004731:Endotoxins; D011422:Propionates / Q000627:therapeutic use*; D011817:Rabbits; D014605:Uveitis / Q000188:drug therapy* / Q000209:etiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D004731:Endotoxins; D011422:Propionates; C043940:pyranoprofen