Regression of gastric T cell lymphoma with eradication of Helicobacter pylori.
Helicobacter pylori is thought to be important in the pathogenesis of chronic active gastritis, peptic ulceration, gastric adenocarcinoma, and gastric B cell lymphoma of mucosa associated lymphoid tissue. The mechanism of evolution from chronic gastritis to monoclonal B cell proliferation is not known but is thought to be dependent on antigen specific T cells to H pylori and its products. Here, we report a case of gastric T cell lymphoma associated with chronic H pylori gastritis which regressed with eradication of the organism. This is the first report of a gastric T cell lymphoma regressing with H pylori eradication, and suggests a causal link between primary gastric T cell lymphoma and this organism.
Bariol
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Department of Gastroenterology, St Vincent's Hospital, Sydney, Australia. bariol@ozemail.com.au
Field
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Vickers
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Ward
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D000328:Adult; D001706:Biopsy; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis