title: Cerebral ischaemic changes in association with the severity of ICA lesions and cerebropetal flow.
abstract: OBJECTIVE
  To study the effect of the severity of internal carotid artery (ICA) lesions on cerebral haemodynamics.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Magnetic resonance (MR) imaging, angiography (MRA) and spectroscopy (MRS) were used to study the prevalence of (border-zone) infarctions, volume flow in the main cerebropetal and middle cerebral arteries (MCA) and metabolic changes in the MCA territories in 170 patients with symptomatic ICA stenoses or occlusions and 25 control subjects.
  
  
  RESULTS
  No significant correlation was found between severity of the carotid lesion and the prevalence of border-zone infarctions. Also, no significant correlation was found with changes in the N -acetyl-aspartate/choline ratio nor with the prevalence of cerebral lactate. In patients with at least one severe ICA lesion, flow in the basilar artery was increased. Flow in the MCA on the symptomatic and asymptomatic side was decreased when at least one ICA was occluded. Total cerebropetal flow (flow through the ICAs plus basilar artery) was decreased when at least one ICA was occluded. No significant correlation was found between changes in cerebropetal flow and the N -acetyl-aspartate/choline ratio nor with the prevalence of border-zone infarctions.
  
  
  CONCLUSIONS
  Border-zone infarctions and ischaemic metabolic changes are not directly the result of cerebral hypoperfusion caused by severe ICA lesions.
authors.affiliation: Department of Radiology, University Medical Center, Utrecht, The Netherlands
authors.forename: K J
authors.initials: KJ
authors.lastname: van Everdingen
authors.forename: C J
authors.initials: CJ
authors.lastname: Klijn
authors.forename: L J
authors.initials: LJ
authors.lastname: Kappelle
authors.forename: B C
authors.initials: BC
authors.lastname: Eikelboom
authors.forename: J
authors.initials: J
authors.lastname: van der Grond
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D016893:Carotid Stenosis / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D002544:Cerebral Infarction / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D003430:Cross-Sectional Studies; D003952:Diagnostic Imaging; D016894:Endarterectomy, Carotid; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D012039:Regional Blood Flow / Q000502:physiology