Approaches permitting and enhancing motoneuron regeneration after spinal cord, ventral root, plexus and peripheral nerve injuries.
The motoneuron has a strong ability to regenerate after injury. However, the problems of nerve cell survival after a proximal axotomy, difficulty in axonal elongation after intraspinal lesion and the lack of target specificity during nerve fibre regrowth interfere with a good functional restitution. Current research has addressed these impediments. New approaches for the management of complicated as well as intraspinal lesions and peripheral nerve trunk injuries are described.
Carlstedt
T
T
The Peripheral Nerve Injury Unit, The Royal National Orthopaedic Hospital, Stanmore, UK. tcarlst@nimr.mrc.ac.uk
D000818:Animals; D006801:Humans; D009046:Motor Neurons / Q000473:pathology / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D017933:Peripheral Nervous System / Q000293:injuries* / Q000473:pathology; D013119:Spinal Cord Injuries / Q000473:pathology / Q000628:therapy*; D013126:Spinal Nerve Roots / Q000293:injuries* / Q000473:pathology