title: Primary osteosarcoma of the distal femur in two consecutive brothers.
abstract: The following report describes two consecutive brothers from a nonimmigrant family, with no identifiable predisposing factors, who presented with osteosarcomas of their distal femurs, one at the age of 18 years and the other at the age of 21 years. Until a cost-effective program is developed to screen for osteosarcoma, a detailed family history should be obtained from every new patient with osteosarcoma and parents should be urged to schedule early evaluations of siblings with complaints of painful extremities. Increased frequency of cytogenetic studies to screen for genetic abnormalities in patients with osteosarcoma is recommended to help elucidate the cause of osteosarcoma.
authors.affiliation: Department of Orthopaedic Surgical Oncology, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Chin
authors.forename: H J
authors.initials: HJ
authors.lastname: Mankin
authors.forename: M C
authors.initials: MC
authors.lastname: Gebhardt
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019645:Arthroplasty, Replacement, Knee; D003582:Cytogenetics; D017809:Fatal Outcome; D005266:Femoral Neoplasms / Q000235:genetics* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008403:Mass Screening; D020360:Neoadjuvant Therapy; D012516:Osteosarcoma / Q000235:genetics* / Q000556:secondary / Q000601:surgery; D014057:Tomography, X-Ray Computed