title: Cytotoxic clerodane diterpene esters from Laetia corymbulosa.
abstract: Three cytotoxic clerodane diterpene esters, corymbulosins A-C, were isolated from an organic extract of the fruit of Laetia corymbulosa (Flacourtiaceae) from Peru. The structures were determined by spectroscopic methods as clerodane diterpenes unsaturated at C-3, C-13(16) and C-14. Corymbulosin A was esterified at C-2 with a decadienoate moiety, while corymbulosins B and C were C-2 epimers esterified at C-6 with a decanoate moiety.
authors.affiliation: Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick Cancer Reasearch and Development Center, MD 21702-1201, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Beutler
authors.forename: K L
authors.initials: KL
authors.lastname: McCall
authors.forename: K
authors.initials: K
authors.lastname: Herbert
authors.forename: T
authors.initials: T
authors.lastname: Johnson
authors.forename: R H
authors.initials: RH
authors.lastname: Shoemaker
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004952:Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D019685:Rosales / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004952:Esters; C419333:corymbulosin A