X inactivation: Tsix and Xist as yin and yang.
A new study shows that expression of Tsix, an antisense Xist gene, can be controlled by imprinting, and that high Tsix activity during X inactivation can protect the future active X chromosome from silencing by Xist. Tsix and Xist seem to have a yin and yang relationship, with opposite effects on X inactivation.
Mlynarczyk
S K
SK
University of California San Francisco, Department of Biochemistry and Biophysics, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143, USA.
Panning
B
B
D000818:Animals; D016375:Antisense Elements (Genetics); D004303:Dosage Compensation, Genetic; D005786:Gene Expression Regulation; D018392:Genomic Imprinting / Q000502:physiology*; D006801:Humans; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism*; D015053:Zygote / Q000502:physiology*
D016375:Antisense Elements (Genetics); D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D014157:Transcription Factors; C077885:XIST non-coding RNA