title: Functional assessment of coronary arteries by poststenotic intravascular Doppler ultrasound.
abstract: This study sought to delineate the impact of the rate pressure product on intraluminal Doppler velocity measurements and to determine the relation between poststenotic vasodilator reserve and percent luminal obstruction in coronary vessels. Twenty patients with single-vessel coronary disease were studied prior to coronary angioplasty and at follow-up 6 months later. Intracoronary velocity reserve after administration of adenosine was measured distal to the stenosis with a Doppler-tipped guide wire and was compared to quantitative coronary angiography and adenosine myocardial perfusion scintigraphy. The rate pressure product was confirmed as significant covariate (ANCOVA, p < 0.005) of intracoronary Doppler reserve. When normalized to rate pressure product, poststenotic Doppler velocity reserve in stenosed arteries was significantly lower than in patent arteries as classified by quantitative coronary angiography (1.7 +/- 0.6 vs. 2.9 +/- 0.5, p < 0.001) and perfusion scintigraphy (1.5 +/- 0.4 vs. 2.8 +/- 0.5, p < 0.001). Normalized Doppler velocity reserve showed a nonlinear but highly significant relation to percent area stenosis [y = 3.0.(1 - exp[0.081 (x - 100)]), p < 0.001]. When normalized Doppler velocity reserve was less than 2.0, coronary disease was identified with 95% specificity and 94% sensitivity in comparison to perfusion scintigraphy. Thus, in coronary arteries poststenotic Doppler reserve and percent area stenosis show a significant nonlinear relation. Doppler velocity reserve when normalized to rate pressure product can be used to characterize the hemodynamic impact of coronary obstructions.
authors.affiliation: Department of Cardiology, University of Vienna, Austria. g.porenta@rudolfinerhaus.at
authors.forename: G
authors.initials: G
authors.lastname: Porenta
authors.forename: T
authors.initials: T
authors.lastname: Binder
authors.forename: D
authors.initials: D
authors.lastname: Moertl
authors.forename: M
authors.initials: M
authors.lastname: Zehetgruber
authors.forename: S
authors.initials: S
authors.lastname: Graf
authors.forename: G
authors.initials: G
authors.lastname: Maurer
authors.forename: P
authors.initials: P
authors.lastname: Probst
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D000368:Aged; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012008:Recurrence; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon; D018608:Ultrasonography, Doppler / Q000295:instrumentation / Q000379:methods*
chemical_list: D013794:Thallium Radioisotopes; D000241:Adenosine