title: Sesquiterpene lactones from Centaurea thessala and Centaurea attica. Antifungal activity.
abstract: The aerial parts of Centaurea thessala ssp. drakiensis and C. attica ssp. attica afforded, in addition to several known sesquiterpene lactones, two new eudesmanolides, 4-epi-sonchucarpolide and its 8-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) derivative and one new eudesmane derivative, named atticin. The in vitro antifungal activity of most compounds was tested against nine fungal species, using the micro-dilution method. All the compounds tested showed great antifungal activity.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, University of Athens, Greece. skaltsa@pharm.uoa.gr
authors.forename: H
authors.initials: H
authors.lastname: Skaltsa
authors.forename: D
authors.initials: D
authors.lastname: Lazari
authors.forename: C
authors.initials: C
authors.lastname: Panagouleas
authors.forename: E
authors.initials: E
authors.lastname: Georgiadou
authors.forename: B
authors.initials: B
authors.lastname: Garcia
authors.forename: M
authors.initials: M
authors.lastname: Sokovic
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D019659:Asteraceae / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D007783:Lactones; D012717:Sesquiterpenes