title: Microsatellite instability in cervical carcinoma.
abstract: OBJECTIVE
  To investigate the incidence of microsatellite instability (MI) in cervical carcinoma and its relationship with clinicopathological characteristics.
  
  
  METHODS
  A retrospective study of 100 cases of cervical carcinoma.
  
  
  RESULTS
  MI, defined as tumor-associated alterations in at least one of five dinucleotide microsatellite markers examined, was detected in 25% of the cervical carcinomas which were observed. There was a nonsignificant trend towards MI occurrence in higher grade tumors, more advanced stage and cases with poor clinical outcome.
  
  
  CONCLUSIONS
  The results suggest that microsatellite instability is present in a subset of cervical carcinoma and may be an independent prognostic factor. Further research with more samples is required.
authors.affiliation: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, N.T., Hong Kong SAR, Shatin, China. tonychung@cuhk.edu.hk
authors.forename: T K
authors.initials: TK
authors.lastname: Chung
authors.forename: T Y
authors.initials: TY
authors.lastname: Ip
authors.forename: G M
authors.initials: GM
authors.lastname: Hampton
authors.forename: V W
authors.initials: VW
authors.lastname: Wang
authors.forename: T H
authors.initials: TH
authors.lastname: Cheung
authors.forename: Y F
authors.initials: YF
authors.lastname: Wong
mesh_terms: D018900:Dinucleotide Repeats; D005260:Female; D006801:Humans; D018895:Microsatellite Repeats; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology