Differential susceptibility of heart, skin, and islet allografts to T cell-mediated rejection.
Although it is widely accepted that there is a hierarchy in the susceptibility of different allografts to rejection, the mechanisms responsible are unknown. We show that the increased susceptibility of H-2K(b+) skin and islet allografts to rejection is not based on their ability to activate more H-2K(b)-specific T cells in vivo; heart allografts stimulate the activation and proliferation of many more H-2K(b)-specific T cells than either skin or islet allografts. Rejection of all three types of graft generate memory cells by 25 days posttransplant. These data provide evidence that neither tissue-specific Ags nor, surprisingly, the number of APCs carried in the graft dictate their susceptibility to T cell-mediated rejection and suggest that the graft microenvironment and size may play a more important role in determining the susceptibility of an allograft to rejection and resistance to tolerance induction.
Jones
N D
ND
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. nicholas.jones@surgery.ox.ac.uk
Turvey
S E
SE
Van Maurik
A
A
Hara
M
M
Kingsley
C I
CI
Smith
C H
CH
Mellor
A L
AL
Morris
P J
PJ
Wood
K J
KJ
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D004198:Disease Susceptibility; D018984:Epitopes, T-Lymphocyte / Q000096:biosynthesis; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology; D006183:H-2 Antigens / Q000096:biosynthesis; D016027:Heart Transplantation / Q000276:immunology; D007108:Immune Tolerance; D007156:Immunologic Memory; D016381:Islets of Langerhans Transplantation / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D016377:Organ Transplantation; D011184:Postoperative Period; D016038:Skin Transplantation / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014184:Transplantation, Homologous
D018984:Epitopes, T-Lymphocyte; D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; D007519:Isoantigens