Microsatellite instability in cervical carcinoma.
OBJECTIVE
To investigate the incidence of microsatellite instability (MI) in cervical carcinoma and its relationship with clinicopathological characteristics.


METHODS
A retrospective study of 100 cases of cervical carcinoma.


RESULTS
MI, defined as tumor-associated alterations in at least one of five dinucleotide microsatellite markers examined, was detected in 25% of the cervical carcinomas which were observed. There was a nonsignificant trend towards MI occurrence in higher grade tumors, more advanced stage and cases with poor clinical outcome.


CONCLUSIONS
The results suggest that microsatellite instability is present in a subset of cervical carcinoma and may be an independent prognostic factor. Further research with more samples is required.
Chung
T K
TK
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, N.T., Hong Kong SAR, Shatin, China. tonychung@cuhk.edu.hk
Ip
T Y
TY
Hampton
G M
GM
Wang
V W
VW
Cheung
T H
TH
Wong
Y F
YF
D018900:Dinucleotide Repeats; D005260:Female; D006801:Humans; D018895:Microsatellite Repeats; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology