title: Microalbuminuria and markers of the atherosclerotic process: the D.E. S.I.R. study.
abstract: The relationship between microalbuminuria and tissue-type plasminogen activator antigen (tPA-ag) and fibrinogen was evaluated in non-diabetic subjects. Subjects were participants of the D.E.S.I. R. (Data from an Epidemiological Study on the Insulin Resistance syndrome) Study. Analyses were carried out on 2248 women and 2402 men for fibrinogen and on 272 women and 284 men for tPA-ag. Microalbuminuria was defined as urinary albumin concentration greater than 20 mg/l. Men with microalbuminuria had a 6% higher fibrinogen concentration than those without (3.07 g/l (95% confidence interval: 2.99,3.15) vs. 2.89 g/l (2.87,2.91), adjusted for age and smoking). This relationship existed in hypertensive as well as non-hypertensive subjects. The association between microalbuminuria and tPA-ag existed only in hypertensive men, those with microalbuminuria having a 21% higher tPA-ag than those without (4.39 ng/ml (3.70,5.08) vs. 3.63 ng/ml (3.32,3.94), adjusted for age and smoking). Adjustment for other risk markers for cardiovascular disease did not change the results. There was no relationship between microalbuminuria and these haemostatic factors in women. The results of this study suggest that in non-diabetic men, microalbuminuria is associated with fibrinogen, but with tPA-ag only when concomitant with hypertension.
authors.affiliation: INSERM, Unit 258, and the Faculty of Medicine Paris-Sud, Villejuif, France. mennen@vjf.inserm.fr
authors.forename: L I
authors.initials: LI
authors.lastname: Mennen
authors.forename: B
authors.initials: B
authors.lastname: Balkau
authors.forename: B
authors.initials: B
authors.lastname: Royer
authors.forename: A
authors.initials: A
authors.lastname: Caradec
authors.forename: M
authors.initials: M
authors.lastname: Marre
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authors.initials: B
authors.lastname: Balkau
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authors.initials: E
authors.lastname: Eschwège
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authors.initials: F
authors.lastname: Alhenc-Gelas
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authors.initials: A
authors.lastname: Bechetoille
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authors.lastname: Gallois
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authors.initials: A
authors.lastname: Girault
authors.forename: M
authors.initials: M
authors.lastname: Marre
authors.forename: M
authors.initials: M
authors.lastname: Brochier
authors.forename: M C
authors.initials: MC
authors.lastname: Chesnier
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authors.lastname: Gasnier
authors.forename: J M
authors.initials: JM
authors.lastname: Le Mauff
authors.forename: A
authors.initials: A
authors.lastname: Caradec
authors.forename: D
authors.initials: D
authors.lastname: Arondel
authors.forename: M
authors.initials: M
authors.lastname: Novak
authors.forename: A
authors.initials: A
authors.lastname: Petrella
authors.forename: A
authors.initials: A
authors.lastname: D'Hour
authors.forename: P
authors.initials: P
authors.lastname: Lépinay
authors.forename: B
authors.initials: B
authors.lastname: Royer
authors.forename: N
authors.initials: N
authors.lastname: Verstraete
authors.forename: P
authors.initials: P
authors.lastname: Aubourg
authors.forename: J
authors.initials: J
authors.lastname: Cogneau
authors.forename: C
authors.initials: C
authors.lastname: Rougeron
authors.forename: V
authors.initials: V
authors.lastname: Diquero
authors.forename: E
authors.initials: E
authors.lastname: Cacès
authors.forename: M
authors.initials: M
authors.lastname: Cailleau
authors.forename: J M
authors.initials: JM
authors.lastname: Jacquelin
authors.forename: J G
authors.initials: JG
authors.lastname: Moreau
authors.forename: F
authors.initials: F
authors.lastname: Rakotozafy
authors.forename: J
authors.initials: J
authors.lastname: Tichet
authors.forename: S
authors.initials: S
authors.lastname: Vol
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000652:urine*; D001161:Arteriosclerosis / Q000097:blood* / Q000150:complications / Q000652:urine*; D015415:Biomarkers; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D010959:Tissue Plasminogen Activator / Q000097:blood*
chemical_list: D015415:Biomarkers; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator