Tyrosine kinase A, autonomic and transmitter receptors, but not innervation, are upregulated in the aging rat prostate.
In the mature rat ventral prostate, epithelial proliferation is accompanied by significant upregulation of tyrosine kinase A, alpha1B and muscarinic acetylcholine M2 receptors as well as the synaptic vesicle-associated membrane proteins synaptobrevin and SV2 as compared with immature prostate tissue. The adrenergic receptors beta1, alpha2A and alpha1 were also up-regulated and translocated in mature rat prostate tissue. Expression of the Schwann cell/axonal marker S100 remained unchanged. These results are suggestive of a marked increase in metabolic activity, calcium influx and autonomic receptor expression in the aging prostate. These changes were not accompanied by an increase in the number of axons.
Slater
M
M
Institute for Biomedical Research and Department of Anatomy and Histology, The University of Sydney, NSW, Australia. michaels@anatomy.usyd.edu.au
Barden
J A
JA
Murphy
C R
CR
D000367:Age Factors; D000375:Aging; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011467:Prostate / Q000294:innervation* / Q000378:metabolism*; D050683:R-SNARE Proteins; D051381:Rats; D017208:Rats, Wistar; D043585:Receptor, Muscarinic M2; D020917:Receptor, trkA / Q000378:metabolism*; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D009418:S100 Proteins / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D015854:Up-Regulation
C547718:Adra1b protein, rat; D015220:Calcium Channels; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D050683:R-SNARE Proteins; D043585:Receptor, Muscarinic M2; D018340:Receptors, Adrenergic, alpha-1; D011976:Receptors, Muscarinic; D009418:S100 Proteins; C489618:Sv2a protein, rat; D020917:Receptor, trkA