Early events in the mammalian germ line.
Germ cells represent the genetic and cellular link between generations, as well as the transmitters of inherited diseases. Despite their central importance, not much is known about the molecular mechanisms whereby a germ cell lineage becomes set aside during development, or how the germ cells, once formed, migrate to the gonads and combine with somatic cells to make a gonad. This article provides a brief review of current knowledge on these issues, with particular focus on the mammalian germ line.
Anderson
O
O
Department of Genetics, Cell Biology and Development, University of Minnesota School of Medicine, Minneapolis 55455, USA.
Heasman
J
J
Wylie
C
C
D000818:Animals; D019070:Cell Lineage / Q000235:genetics*; D002465:Cell Movement / Q000502:physiology*; D005260:Female; D005854:Germ Cells / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D006066:Gonads / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D008297:Male; D051379:Mice; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism; D013997:Time Factors