title: [Evaluation of myorelaxant drug action in surgery for pediatric   oncopathologies].
abstract: Neuro-muscular transmission was studied in 100 children operated on for retroperitoneal and mediastinal tumors using the TOF-Guard accelograph. The device was instrumental in cutting down intubation time, monitoring neuro-muscular transmission system (NMTS), predicting the point of transmission recovery and making extubation possible. NMTS monitoring established such advantages of continuous myorelaxant infusion as lower rate of drug administration and lower total dose; the latter is important to avoid drug cumulation. Due to TOF-Guard application 25-30 and 20% of such myorelaxant drugs as arduan and mivacron was saved, respectively; infusion technique required no decurarization medication. There is quite a potential of variation of myorelaxant administration at different stages of surgery and anesthesia.
authors.affiliation: Research Institute of Pediatric Oncology and Hematology, N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: N V
authors.initials: NV
authors.lastname: Matinian
authors.forename: A I
authors.initials: AI
authors.lastname: Saltanov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Illarionov
authors.forename: Z S
authors.initials: ZS
authors.lastname: Ordukhanian
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D008479:Mediastinal Neoplasms / Q000601:surgery*; D000077590:Mivacurium; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000494:pharmacology*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology; D017300:Pipecuronium / Q000494:pharmacology; D012119:Respiration / Q000187:drug effects; D012186:Retroperitoneal Neoplasms / Q000601:surgery*
chemical_list: D007546:Isoquinolines; D009125:Muscle Relaxants, Central; D003473:Neuromuscular Nondepolarizing Agents; D017300:Pipecuronium; D000077590:Mivacurium