HLA-B*1559: a hybrid allele including exon 2 of HLA-B35 and exon 3 of HLA-B15 and serologically typed as B35.
The new allele HLA-B*1559 described is of Hispanic origin. This allele carries the exon 2 of HLA-B*35 alleles, and is identical to HLA-B*3501 and the exon 3 of HLA-B*1530. Serologically it is typed as B35. The most likely scenario for its generation seems to be a gene conversion event that involved the, frequent in Hispanic populations, B*1522 allele and a B*1530 allele. A segment of the B*1530 allele that included at least the sequences 412-419 would be transferred on a B*1522 background.
Magira
E
E
Department of Pediatrics, University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia, USA.
Beznik-Cizman
B
B
Monos
D
D
D000483:Alleles; D001483:Base Sequence; D018076:DNA, Complementary; D005091:Exons; D015235:HLA-B Antigens / Q000145:classification / Q000235:genetics*; D059910:HLA-B15 Antigen; D015797:HLA-B35 Antigen / Q000235:genetics*; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D018076:DNA, Complementary; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D015797:HLA-B35 Antigen