[Antioxidant defense status of children in the early post-operative period in Wilms' tumor]  .
Lipid peroxidation (LP) was studied in 85 patients, aged 1-14, with Wilms tumor (stage II-IV). In addition to standard infusions, patients of group I received ascorbic acid (AA) 15 mg/body weight postoperatively while, in group II, AA 25-35 mg/body was supplemented with alpha-tocopherol 1.4-1.9 mg/body. LP was evaluated by assaying malonic dialdehyde (MDA) and--such enzymes A3 superoxide dismutase--SOD; catalase--CA and nonenzymatic components (AA and blood-alpha-tocopherol) for status of antioxidant defense. Medium mass molecules (MMM) were used as markers of endogenous intoxication. Said procedures were carried out before surgery and on days 1, 3 and 5 after operation. A significant decrease in endogenous AA and alpha-tocopherol was established, as compared with healthy children, while a significant increase was registered in MDA, MMM, SOD and CA levels. The LP investigation confirmed the systemic impact of tumor. Surgical stress contributed to the rise of LP thus compromising antioxidant defense. Postoperative administration of high doses of AA in combination with alpha-tocopherol reduced the rates of LP processes.
Ordukhanian
Z S
ZS
Research Institute of Pediatric Oncology and Hematology, N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
Gorozhanskaia
E G
EG
Saltanov
A I
AI
D000293:Adolescent; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000097:blood / Q000627:therapeutic use*; D002374:Catalase / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000097:blood* / Q000601:surgery; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009392:Nephrectomy; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors; D014810:Vitamin E / Q000097:blood / Q000627:therapeutic use*; D009396:Wilms Tumor / Q000097:blood* / Q000601:surgery
D000975:Antioxidants; D014810:Vitamin E; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid