Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists.
The small (21-kDa) guanine nucleotide-binding protein Ras plays a central role in the regulation of cell growth and division. In the cardiac myocyte, it has been implicated in the hypertrophic adaptation. We have recently examined the ability of hypertrophic agonists such as endothelin-1, phenylephrine and phorbol esters to increase the "activity" (GTP loading) of Ras. We have also studied the signaling events that lead to activation of Ras and the processes that respond to Ras activation. In this brief review, we describe these studies and set them within the context of the hypertrophic response.
Sugden
P H
PH
National Heart and Lung Institute (NHLI) Division (Cardiac Medicine Section), Imperial College School of Medicine, London, UK.
Clerk
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D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D006332:Cardiomegaly / Q000139:chemically induced / Q000378:metabolism*; D019332:Endothelin-1 / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000187:drug effects / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010656:Phenylephrine / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D018631:ras Proteins / Q000187:drug effects / Q000378:metabolism
D000316:Adrenergic alpha-Agonists; D019332:Endothelin-1; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D020559:Monomeric GTP-Binding Proteins; D018631:ras Proteins; D013755:Tetradecanoylphorbol Acetate