title: Malignant peripheral nerve sheath tumor of the esophagus.
abstract: BACKGROUND
  Sarcomas of the esophagus are rare representing 0.1-1.5% of all esophageal tumors. We report a case of malignant peripheral nerve sheath tumor (MPNST) of the esophagus in a 60-year-old woman.
  
  
  METHODS
  The diagnosis was made preoperatively on endoscopic biopsy and confirmed after tumor resection by immunohistochemistry as well as electron microscopy. The patient underwent abdominal-thoracicen bloc esophagectomy with mediastinal lymphadenectomy and intrathoracic esophagogastrostomy.
  
  
  RESULTS
  Our therapeutic concept for the first case of a high-grade MPNST (malignant schwannoma) of the esophagus resulted in a recurrence-free interval of 4 years.
  
  
  CONCLUSIONS
  The therapy of choice was abdominal-thoracic en bloc esophagectomy with tumor-free resection margins and esophageal reconstruction with the stomach. After R0-resection we found no indication for adjuvant radio- and/or chemotherapy.
authors.affiliation: Department of Surgery, Otto von Guericke University, Magdeburg, Germany. thomas.manger@medizin-uni-magdeburg.de
authors.forename: T
authors.initials: T
authors.lastname: Manger
authors.forename: M
authors.initials: M
authors.lastname: Pross
authors.forename: C
authors.initials: C
authors.lastname: Haeckel
authors.forename: H
authors.initials: H
authors.lastname: Lippert
mesh_terms: D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D016629:Esophagectomy / Q000379:methods; D004947:Esophagus / Q000601:surgery; D005260:Female; D005773:Gastroscopy; D006801:Humans; D007120:Immunochemistry; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D019651:Plastic Surgery Procedures