Biomesogenic matrix systems.
The bifunctionally reactive nucleoside and distant nucleoside analogs adenosine (Ado), S-[(adenine-9-yl)methoxyethyl]-L-cysteine (Na-salt) (cysA) and 9-vinyladenine (vA) in aqueous solutions assemble on complementary polyuridylic acid templates to form complex lyomesophases. The systems are investigated by polarizing microscopy, differential scanning calorimetry (DSC) and 1H- and 31P-nmr spectroscopies, assisted by molecular modeling studies. The results indicate the importance of biomesogenic (pre)ordering in nucleic acid native and artificial matrix reactions.
Meister
W V
WV
Martin Luther University Halle-Wittenberg, Institute of Biochemistry, Saale, Germany. meister@biochemtech.uni-halle.de
Lindau
S
S
Hauser
A L
AL
Bohley
C
C
Gromann
U
U
Naumann
S
S
Madre
M
M
Kovalenko
L
L
Bischoff
G
G
Zhuk
R
R
Hoffmann
S
S
D000225:Adenine / Q000031:analogs & derivatives / Q000737:chemistry; D000241:Adenosine / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy; D008859:Microscopy, Polarization; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011072:Poly U / Q000737:chemistry; D011131:Polyribonucleotides / Q000737:chemistry*; D013816:Thermodynamics
D046911:Macromolecular Substances; D011131:Polyribonucleotides; D011072:Poly U; D000225:Adenine; D000241:Adenosine