Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children.
In a randomized, double-blind controlled trial, 42 children with irritable bowel syndrome (IBS) were given pH-dependent, enteric-coated peppermint oil capsules or placebo. After 2 weeks, 75% of those receiving peppermint oil had reduced severity of pain associated with IBS. Peppermint oil may be used as a therapeutic agent during the symptomatic phase of IBS.
Kline
R M
RM
University of Missouri-Columbia, Department of Child Health, Division of Pediatric Gastroenterology, Columbia, Missouri, USA.
Kline
J J
JJ
Di Palma J
Barbero
G J
GJ
D015746:Abdominal Pain / Q000175:diagnosis / Q000209:etiology; D000293:Adolescent; D000367:Age Factors; D002648:Child; D003109:Colonic Diseases, Functional / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D036142:Mentha piperita; D010147:Pain Measurement; D010276:Parasympatholytics / Q000627:therapeutic use*; D010938:Plant Oils / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013608:Tablets, Enteric-Coated / Q000627:therapeutic use*; D016896:Treatment Outcome
D010276:Parasympatholytics; D010938:Plant Oils; D013608:Tablets, Enteric-Coated; C015424:peppermint oil