title: The utility of ultrasonographically guided large-core needle biopsy: results from 500 consecutive breast biopsies.
abstract: Five hundred ultrasonographically guided large-core needle breast biopsies of solid masses were performed in 446 women. Histopathologic results were correlated with imaging findings. Ultrasonographically guided large-core needle biopsy resulted in diagnosis of malignancy (n = 124) or severe atypical ductal hyperplasia (n = 4) in 128 lesions (26%). In the remaining 372 lesions (74%), ultrasonographically guided large-core needle biopsy yielded benign pathologic results. Follow-up of more than 1 year (n = 225), results of surgical excision (n = 50), or both were obtainable in 275 (74%) of the benign lesions. No malignancies were discovered at surgical excision or during follow-up of this group of benign lesions. There were no complications related to large-core needle biopsy that required additional treatment. Ultrasonographically guided large-core needle biopsy is a safe and accurate method for evaluating breast lesions that require tissue sampling.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: D N
authors.initials: DN
authors.lastname: Smith
authors.forename: M L
authors.initials: ML
authors.lastname: Rosenfield Darling
authors.forename: J E
authors.initials: JE
authors.lastname: Meyer
authors.forename: C M
authors.initials: CM
authors.lastname: Denison
authors.forename: D I
authors.initials: DI
authors.lastname: Rose
authors.forename: S
authors.initials: S
authors.lastname: Lester
authors.forename: A
authors.initials: A
authors.lastname: Richardson
authors.forename: C M
authors.initials: CM
authors.lastname: Kaelin
authors.forename: E
authors.initials: E
authors.lastname: Rhei
authors.forename: R L
authors.initials: RL
authors.lastname: Christian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014463:Ultrasonography