Contribution of dietary oxalate to urinary oxalate excretion.
BACKGROUND
The amount of oxalate excreted in urine has a significant impact on calcium oxalate supersaturation and stone formation. Dietary oxalate is believed to make only a minor (10 to 20%) contribution to the amount of oxalate excreted in urine, but the validity of the experimental observations that support this conclusion can be questioned. An understanding of the actual contribution of dietary oxalate to urinary oxalate excretion is important, as it is potentially modifiable.


METHODS
We varied the amount of dietary oxalate consumed by a group of adult individuals using formula diets and controlled, solid-food diets with a known oxalate content, determined by a recently developed analytical procedure. Controlled solid-food diets were consumed containing 10, 50, and 250 mg of oxalate/2500 kcal, as well as formula diets containing 0 and 180 mg oxalate/2500 kcal. Changes in the content of oxalate and other ions were assessed in 24-hour urine collections.


RESULTS
Urinary oxalate excretion increased as dietary oxalate intake increased. With oxalate-containing diets, the mean contribution of dietary oxalate to urinary oxalate excretion ranged from 24.4 +/- 15.5% on the 10 mg/2500 kcal/day diet to 41.5 +/- 9.1% on the 250 mg/2500 kcal/day diet, much higher than previously estimated. When the calcium content of a diet containing 250 mg of oxalate was reduced from 1002 mg to 391 mg, urinary oxalate excretion increased by a mean of 28.2 +/- 4.8%, and the mean dietary contribution increased to 52.6 +/- 8.6%.


CONCLUSIONS
These results suggest that dietary oxalate makes a much greater contribution to urinary oxalate excretion than previously recognized, that dietary calcium influences the bioavailability of ingested oxalate, and that the absorption of dietary oxalate may be an important factor in calcium oxalate stone formation.
Holmes
R P
RP
Department of Urology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1094, USA. rholmes@wfubmc.edu
Goodman
H O
HO
Assimos
D G
DG
D000328:Adult; D002136:Calcium, Dietary / Q000494:pharmacology; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004586:Electrophoresis / Q000379:methods; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008297:Male; D010070:Oxalates / Q000008:administration & dosage* / Q000494:pharmacology / Q000652:urine*
D002136:Calcium, Dietary; D010070:Oxalates