title: Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice.
abstract: To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx). MK-801 or dantrolene, but not FK506, suppressed convulsive seizures in EL mice; only MK-801 reduced NOx in the brain. Our results suggested involvement of the N-methyl-D-aspartate receptor-channel complex and intracellular calcium mobilization, but not calcineurin, in the convulsions of EL mice.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Kagoshima University, 8-35-1, Sakuragaoka, 890-8520, Kagoshima, Japan. nagatomo@m2.kufm.kagoshimak-u.ac.jp  
authors.forename: I
authors.initials: I
authors.lastname: Nagatomo
authors.forename: W
authors.initials: W
authors.lastname: Hashiguchi
authors.forename: M
authors.initials: M
authors.lastname: Tominaga
authors.forename: Y
authors.initials: Y
authors.lastname: Akasaki
authors.forename: M
authors.initials: M
authors.lastname: Uchida
authors.forename: M
authors.initials: M
authors.lastname: Takigawa
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects; D019703:Calcineurin / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003620:Dantrolene / Q000008:administration & dosage*; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D051379:Mice; D008815:Mice, Inbred Strains; D009125:Muscle Relaxants, Central / Q000008:administration & dosage; D009566:Nitrates / Q000032:analysis / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D009573:Nitrites / Q000032:analysis / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012640:Seizures / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D016559:Tacrolimus / Q000008:administration & dosage*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007166:Immunosuppressive Agents; D009125:Muscle Relaxants, Central; D009566:Nitrates; D009573:Nitrites; D016194:Receptors, N-Methyl-D-Aspartate; D009569:Nitric Oxide; D016291:Dizocilpine Maleate; D019703:Calcineurin; D003620:Dantrolene; D002118:Calcium; D016559:Tacrolimus