title: Blunted rise in platelet count in critically ill patients is associated with worse outcome.
abstract: OBJECTIVE
  To test the hypothesis that a low rate of change of platelet counts (PCs) after admission to the intensive care unit (ICU) is associated with mortality. Low PCs are known to be associated with disease severity in critically ill patients, but the relevance of time-dependent changes of PCs has not been investigated.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  A 12-bed surgical ICU of a university hospital.
  
  
  METHODS
  All adult patients admitted to the ICU for at least 4 days during a 7-yr period.
  
  
  METHODS
  At admission, Acute Physiology and Chronic Health Evaluation scores were calculated. PCs and leukocyte counts were analyzed from admission to day 10. The daily rise of the PCs (deltaPC/deltat from day 2 to day 10 was calculated. Rates for 30-day mortality as well as hospital mortality were determined.
  
  
  RESULTS
  A total of 1,415 admissions were studied. Median PCs (interquartile range) initially decreased and subsequently increased, with a higher PC in 1,203 survivors than in 212 nonsurvivors from day 2 onward (302 [range,181-438] x 10(3)/mm3/day vs. 129 [range, 62-228] x 10(3)/mm3 at day 10; p < 0.001). After stratification of patients per type of surgery, within each group PC was also higher in survivors. Mean deltaPC/deltat was more than five times higher in survivors compared with nonsurvivors: 30 +/- 46 x 10(3)/mm3/day vs. 6 +/- 28 x 10(3)/mm3/day (p < 0.001). The area under the receiving operating characteristic curve of deltaPC/deltat for 30-day survival was 0.743 compared with 0.728 for the Acute Physiology and Chronic Health Evaluation. Leukocyte counts showed marginal differences between nonsurvivors and survivors.
  
  
  CONCLUSIONS
  A blunted or absent rise in PCs in critically ill patients is associated with increased mortality. deltaPC/deltat is a readily available and simple parameter to improve assessment of critically ill patients.
authors.affiliation: Department of Surgery, University Hospital Groningen, The Netherlands. m.w.n.nijsten@chir.azg.nl
authors.forename: M W
authors.initials: MW
authors.lastname: Nijsten
authors.forename: H J
authors.initials: HJ
authors.lastname: ten Duis
authors.forename: J G
authors.initials: JG
authors.lastname: Zijlstra
authors.forename: R J
authors.initials: RJ
authors.lastname: Porte
authors.forename: J H
authors.initials: JH
authors.lastname: Zwaveling
authors.forename: J C
authors.initials: JC
authors.lastname: Paling
authors.forename: T H
authors.initials: TH
authors.lastname: The
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016638:Critical Illness / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007249:Inflammation; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D016019:Survival Analysis; D013922:Thrombocytosis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors