title: Histopathological variants of central neurocytoma: Report of 10 cases.
abstract: Central neurocytoma is a rare neuronal tumor affecting young adults and usually located in the lateral ventricles. Post-operative prognosis is generally good. Histologically, central neurocytoma is composed of isomorphous small round or ovoid cells alternating with irregularly shaped patches of fibrillary matrix similar to the neuropile. In a series of 10 cases, two central neurocytomas were histologically "atypical" at first examination. One was intra-ventricular, and the second had an intra-parenchymatous juxta-ventricular location. Both were highly cellular with mitotic activity, and tumor necrosis was seen in one. Neuronal differentiation was assessed by synaptophysin immunoreactivity in all 10 cases and by ultrastructural examination in four, including the two "atypical" forms. Neuronal differentiation was less marked in these "atypical" forms, one also presenting focal GFAP immunoreactivity. The proliferative potential was determined by MIB-1 labeling index and compared with clinical outcome. The eight classical central neurocytomas had a MIB-1 labeling index < 2.3%, whereas the two "atypical" forms had a MIB-1 labeling index > 5.2% and both recurred. We think that there is a spectrum of small-cell neuronal tumors. The two extremes could be the central neurocytoma and the primary cerebral neuroblastoma, while the intermediate forms might be qualified as "atypical neurocytoma". In our series, the histological and immunohistochemical criteria of biological aggressiveness appeared to be high mitotic activity, tumor necrosis, loss of neuronal differentiation and high MIB-1 labelling index.
authors.affiliation: Laboratoire d'Anatomie Pathologique et de Neuropathologie, Université Victor Ségalen, Bordeaux.
authors.forename: A
authors.initials: A
authors.lastname: Favereaux
authors.forename: A
authors.initials: A
authors.lastname: Vital
authors.forename: H
authors.initials: H
authors.lastname: Loiseau
authors.forename: V
authors.initials: V
authors.lastname: Dousset
authors.forename: J
authors.initials: J
authors.lastname: Caille
authors.forename: K
authors.initials: K
authors.lastname: Petry
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D004727:Endothelium / Q000473:pathology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008938:Mitosis; D009336:Necrosis; D009364:Neoplasm Recurrence, Local; D018306:Neurocytoma / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase