Orbital osteoclastoma of apparent extraskeletal origin in a pagetic patient: a case report.
A large mass in the right orbit, causing proptosis, ptosis of the right upper eyelid, and limitation to eye movements, was surgically removed from a 51-year-old woman suffering from Paget's bone disease (PBD). Histologically, a giant cell tumor of the bone (osteoclastoma) was diagnosed. No bony involvement was apparent either operatively, microscopically, or on preoperative computed tomographic scans. The neoplasm has not recurred in a 3-year follow-up. In addition to the fact that osteoclastoma complicating PBD is rare, the extraskeletal origin of the tumor is a matter of interest and can be tentatively explained by an unusually powerful systemic stimulus acting on circulating osteoclast precursors. HUM PATHOL 31:1527-1531.
Pecorella
I
I
Dipartimento di Medicina Sperimentale e Patologia, Università degli Studi La Sapienza, Roma, Italy.
Ciardi
A
A
Amadeo
G
G
Baiocchini
A
A
Marasco
A
A
Di Tondo
U
U
D005260:Female; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D010001:Osteitis Deformans / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed