A noninvasive measurement of reactive hyperemia that can be used to assess resistance artery endothelial function in humans.
We demonstrated that endothelial function in patients with essential hypertension is impaired by a decrease in nitric oxide production using both reactive hyperemia and acetylcholine infusion methods. This noninvasive method of evaluating reactive hyperemia is a useful alternative to intra-arterial infusions of vasoactive agents in the assessment of resistance vessels' endothelial function in forearm circulation.
Higashi
Y
Y
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan. yhigashi@mcai.med.hiroshima-u.ac.jp
Sasaki
S
S
Nakagawa
K
K
Matsuura
H
H
Kajiyama
G
G
Oshima
T
T
D000109:Acetylcholine; D000328:Adult; D000704:Analysis of Variance; D004730:Endothelium, Vascular / Q000503:physiopathology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D007548:Isosorbide Dinitrate; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D012039:Regional Blood Flow; D014655:Vascular Resistance / Q000502:physiology*; D014665:Vasodilator Agents; D019323:omega-N-Methylarginine / Q000494:pharmacology
D004791:Enzyme Inhibitors; D014665:Vasodilator Agents; D019323:omega-N-Methylarginine; D019001:Nitric Oxide Synthase; D007548:Isosorbide Dinitrate; D000109:Acetylcholine