Trifluoromethanesulfonic anhydride-promoted alpha-bromination of ketones with grignard reagent or magnesium bromide.
The direct alpha-bromination of various ketones using trifluoromethanesulfonic anhydride and Grignard reagent or magnesium bromide in ether gave the corresponding alpha-bromo ketones in moderate to good yields under mild reaction conditions.
Nishiyama
T
T
Department of Applied Chemistry, Faculty of Engineering & High Technology Research Center, Kansai University, Suita, Osaka, Japan. organic@ipcku.kansai-u.ac.jp
Ono
Y
Y
Kurokawa
S
S
Kimura
S
S
D001966:Bromine / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*
D007659:Ketones; D008698:Mesylates; D009942:Organometallic Compounds; C067783:ethyl magnesium bromide; C012077:trifluoromethanesulfonic acid; D001966:Bromine