title: Synthesis and antiviral activity of novel methylene cyclopropyl nucleosides.
abstract: Novel exomethylene cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5 was synthesized in 4 steps, from Feists acid 1 and was condensed with purine derivatives by the SN2 type reaction to give some cyclopropyl nucleosides. The synthesized nucleosides did not showed any significant antiviral activity against HSV-1, HSV-2, HCMV, HIV-1, HIV-2, and HBV up to 100 microM.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, Chonnam National University, Kwangju, Korea.
authors.forename: E Y
authors.initials: EY
authors.lastname: Kwak
authors.forename: J H
authors.initials: JH
authors.lastname: Hong
authors.forename: C K
authors.initials: CK
authors.lastname: Lee
authors.forename: B G
authors.initials: BG
authors.lastname: Choi
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D014780:Viruses / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003521:Cyclopropanes; D009705:Nucleosides