Capsular reactions of Cryptococcus neoformans with polyspecific and oligospecific polyclonal anticapsular antibodies.
Monoclonal antibodies to the capsular polysaccharide of Cryptococcus neoformans produce distinct capsular reactions and have biological activities that are determined by serotype specificity. In the present study, polyclonal rabbit anticapsular antibodies were cross-absorbed to produce serotype specificities similar to those of monoclonal antibodies. The results showed that polyclonal and monoclonal antibodies with similar serotype specificities have similar capsular reactions and biological activities.
MacGill
T C
TC
Department of Microbiology, School of Medicine, University of Nevada, Reno, Nevada 89557, USA.
MacGill
R S
RS
Kozel
T R
TR
D000818:Animals; D000908:Antibodies, Fungal / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000946:Antigens, Fungal / Q000276:immunology*; D003176:Complement C3 / Q000378:metabolism; D003170:Complement Pathway, Alternative; D003455:Cryptococcus neoformans / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*; D011817:Rabbits
D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal; D003176:Complement C3; D011134:Polysaccharides; C027478:glucuronoxylomannan