CD1 molecules and CD1-dependent T cells in bacterial infections: a link from innate to acquired immunity?
The MHC class I-like, non-polymorphic CD1 molecules represent a novel system for the presentation of glycolipid antigens to T lymphocytes. CD1-mediated T cell responses appear to play distinct roles during bacterial infections such as in tuberculosis. This review deals with two aspects of CD1-mediated immune reactions. First we discuss the role of group II CD1-dependent NK T cells in bacterial infection. Second, we provide an insight into differential intracellular meeting points for antigen processing between group I CD1 molecules, mycobacteria and mycobacterial glycolipid antigens.
Schaible
U E
UE
Max-Planck-Institute for Infection Biology, Berlin, Germany. schaible@mpiib-berlin.mpg.de
Kaufmann
S H
SH
D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology*; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D013601:T-Lymphocytes / Q000276:immunology* / Q000382:microbiology*
D018949:Antigens, CD1