title: Conserved gene cluster at replication origins of the alpha-proteobacteria Caulobacter crescentus and Rickettsia prowazekii.
abstract: A 30-kb region surrounding the replication origin in Caulobacter crescentus was analyzed. Comparison to the genome sequence of another alpha-proteobacterium, Rickettsia prowazekii, revealed a conserved cluster of genes (RP001, hemE, hemH, and RP883) that overlaps the established origin of replication in C. crescentus and the putative origin of replication in R. prowazekii. The genes flanking this cluster differ between these two organisms. We therefore propose that this conserved gene cluster can be used to identify the origin of replication in other alpha-proteobacteria.
authors.affiliation: Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada.
authors.forename: A K
authors.initials: AK
authors.lastname: Brassinga
authors.forename: R
authors.initials: R
authors.lastname: Siam
authors.forename: G T
authors.initials: GT
authors.lastname: Marczynski
mesh_terms: D020561:Alphaproteobacteria / Q000145:classification / Q000235:genetics; D001483:Base Sequence; D016935:Caulobacter crescentus / Q000235:genetics*; D017124:Conserved Sequence; D005798:Genes, Bacterial; D005810:Multigene Family; D018741:Replication Origin / Q000235:genetics*; D012283:Rickettsia prowazekii / Q000235:genetics*; D017422:Sequence Analysis, DNA