New marine cembrane-type diterpenoids from the Okinawan soft coral Clavularia koellikeri.
Seven new marine diterpenoids having a cembrane skeleton were isolated from the Okinawan soft coral Clavularia koellikeri. Their structures were determined based on the results of spectroscopic analysis and chemical conversions. Compound 1 showed cytotoxic activity against human colorectal adenocarcinoma cells (DLD-1, IC(50) 4.2 g/mL) and strong growth inhibition against human T lymphocytic leukemia cells (MOLT-4, IC(50) 0.9 g/mL).
Iwashima
M
M
Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Matsumoto
Y
Y
Takahashi
H
H
Iguchi
K
K
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D015179:Colorectal Neoplasms / Q000473:pathology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes