title: Control of hypertension in postoperative patients.
abstract: In this paper, adaptive control systems have been developed for the closed-loop control of mean arterial pressure using vasoactive drugs. An adaptive algorithm based on generalized predictive control law has been presented. A adaptive PI controller has been designed. The recursive least-square identification algorithm is used for on-line parameter estimation. The supervisor is added to provide safety and efficacy of control under the consideration of the physical and physiological constraints. Extensive computer simulation in the presence of unpredictable disturbances shows the system is capable of inducing hypertension.
authors.affiliation: School of Electronic and Electrical Engineering, Nanyang Technological University, Singapore 639798.
authors.forename: X H
authors.initials: XH
authors.lastname: Meng
authors.forename: K Y
authors.initials: KY
authors.lastname: Zhu
authors.forename: S M
authors.initials: SM
authors.lastname: Krishnan
authors.forename: Y S
authors.initials: YS
authors.lastname: Tan
mesh_terms: D000465:Algorithms; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D003198:Computer Simulation; D004360:Drug Therapy, Computer-Assisted; D005246:Feedback; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D007262:Infusions, Intravenous; D009599:Nitroprusside / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D009599:Nitroprusside