A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology.
Frølund
B
B
Departments of Medicinal Chemistry and Pharmacology, Centre for Drug Design and Transport, The Royal Danish School of Pharmacy, 2 Universitetsparken, DK 2100 Copenhagen, Denmark.
Tagmose
L
L
Liljefors
T
T
Stensbøl
T B
TB
Engblom
C
C
Kristiansen
U
U
Krogsgaard-Larsen
P
P
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism / Q000648:ultrastructure; D002478:Cells, Cultured; D018756:GABA Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008958:Models, Molecular; D009118:Muscimol / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D018408:Patch-Clamp Techniques; D010880:Piperidines / Q000737:chemistry / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000378:metabolism
D018756:GABA Antagonists; D007555:Isoxazoles; D010880:Piperidines; D011963:Receptors, GABA-A; C073009:5-(4-piperidyl)isoxazol-3-ol; D009118:Muscimol