Relationship between single voided urine protein/creatinine ratio and 24-hour urine protein excretion rate among children and adolescents in Taiwan.
BACKGROUND
As there have been few studies conducted on children or adolescents, the purpose of this study was evaluate the relationship between single voided urine protein/creatinine (Up/Ucr) ratio and 24-hour urine protein excretion rate (PER), especially among children and adolescents in Taiwan.


METHODS
After multistage random sampling, we collected 1,072 fasting single voided urine samples and 125 24-hour urine samples from seven- to 18-year-old students in Taiwan. We calculated the Up/Ucr of single voided urine samples and the 24-hour PER in urine.


RESULTS
The mean value and the 95th percentile of the fasting single voided urine Up/Ucr ratio were 0.118 and 0.235, respectively. The mean value and the 95th percentile of the 24-hour PER were 3.61 and 5.66 mg/h/m2, respectively. There was no significant difference in Up/Ucr ratio between boys and girls. Up/Ucr ratio decreased significantly as age increased. The fasting single voided Up/Ucr ratio was highly correlated with 24-hour PER, with r2 = 0.95 (p < 0.001).


CONCLUSIONS
Fasting single voided Up/Ucr ratio is a good marker of 24-hour PER. It is also a simple, easy, convenient and speedy method to measure Up excretion. The single voided Up/Ucr ratio may also serve as a reference for the clinical diagnosis of Up excretion among normal subjects.
Chang
J B
JB
Department of Pathology, National Defense Medical Center, Taipei, Taiwan, ROC.
Chen
Y H
YH
Chu
N F
NF
D000293:Adolescent; D002648:Child; D002940:Circadian Rhythm; D003404:Creatinine / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011507:Proteinuria / Q000652:urine*
D003404:Creatinine