title: [Influence of histopathological factors on dynamic MR mammography].
abstract: OBJECTIVE
  To assess the histopathological background of enhancement mechanisms in dynamic MR mammography studies.
  
  
  METHODS
  The dynamic MR mammography (MRM) examinations were done with a 1.5 T MR imager (Magnetom Vision, Siemens) using a double breast coil and a coronal FLASH-3D sequence. Enhancement data were acquired during 9 minutes post contrast medium injection (Gd-DTPA 0.2 mmol/kg). Acquisition time was 87 sec/slab. Early enhancement at the first post contrast measurement (E1) and slope of wash-out (SE2-L) were calculated. In immunohistology, proliferation was assessed by the monoclonal antibody Ki 67, capillaries were stained by a CD 31 antibody. Of a total of 48 operated patients, 58 lesions and 46 surrounding tissues were evaluated.
  
  
  RESULTS
  Cellularity, capillary density and proliferation showed statistically significant correlations with E1 (p < 0.01). In multiple regression analysis, E1 was significantly associated only with high cellularity (p = 0.002) and the combination of high cellularity and high microvessel density (p = 0.002); a negative slope of wash out was significantly associated only with malignant histology (p = 0.027).
  
  
  CONCLUSIONS
  Our findings indicate a direct influence of cellularity and microvessel density on early enhancement. The expression of the proliferation marker Ki 67 was not an independent predictor for contrast enhancement.
authors.affiliation: Abteilung Radiologische Diagnostik, Universitätsklinikum Tübingen. mms@uni-tuebingen.de
authors.forename: M
authors.initials: M
authors.lastname: Müller-Schimpfle
authors.forename: F
authors.initials: F
authors.lastname: Noack
authors.forename: G
authors.initials: G
authors.lastname: Oettling
authors.forename: G
authors.initials: G
authors.lastname: Haug
authors.forename: D
authors.initials: D
authors.lastname: Kienzler
authors.forename: M
authors.initials: M
authors.lastname: Geppert
authors.forename: K
authors.initials: K
authors.lastname: Dietz
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D002196:Capillaries / Q000473:pathology; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008327:Mammography / Q000379:methods; D008875:Middle Aged; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA