Transport of nutrients across the choroid plexus.
A brief outline is given first of the early history of the ventricles and the strange ideas of their functions from Galen to the enlightenment of the Renaissance with the work of Versalius. This is followed by a description of the histology of the choroid plexuses (CP) and discussion on the functions of the choroid plexus and on the composition of cerebrospinal fluid (CSF). The methods of measuring the rate of secretion of CSF will be outlined and the possible nutritive functions of the choroid plexuses will be considered. The role of the choroid plexuses in the control of the concentration of glucose and amino acids in CSF will be compared with data from in vitro experiments to that from the isolated vascularly perfused choroid plexuses. The handling of peptides and proteins by the CP and the synthesis of these molecules by this tissue is then discussed and the effects of lead on the synthesis of transthyretin by this tissue. Finally, reference will be made to the extensive neuro-endocrine role of the CP and efflux systems across the tissue for lipid soluble molecules.
Segal
M B
MB
Guy's, King's and St. Thomas' School of Biomedical Sciences, King's College London, St. Thomas' Hospital, London SE1 7EH, United Kingdom. malcolm.segal@kcl.ac.uk
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000502:physiology; D002831:Choroid Plexus / Q000166:cytology / Q000378:metabolism*; D005333:Fetus / Q000502:physiology; D006801:Humans; D010477:Perfusion; D011228:Prealbumin / Q000378:metabolism
D000596:Amino Acids; D011228:Prealbumin