Gonadotropin-releasing hormone analogue therapy for peritoneal inclusion cysts after gynecological surgery.
OBJECTIVE
The purpose of this report is to estimate the effectiveness of gonadotropin-releasing hormone analogue (Gn-RHa) therapy for peritoneal inclusion cysts.


METHODS
Patients who had cystic masses that developed after gynecological surgery and were strongly suspected of being peritoneal inclusion cysts based on the results of ultrasound, magnetic resonance imaging (MRI), and tumor marker studies, were treated with a Gn-RHa (buserelin acetate or leuprorelin acetate). Buserelin acetate was administered at a dose of 900 microg/day, and leuprorelin acetate at a dose of 3.75 mg/month. Ultrasonography was performed in the outpatient clinic every 2 weeks after the start of administration to measure the diameter of cysts.


RESULTS
We treated 8 patients with peritoneal inclusion cysts conservatively with a Gn-RHa. The cysts resolved in 7 of the patients. Two of them developed a recurrence, but further Gn-RHa therapy was followed by complete resolution of the cysts in one patient and we resume Gn-RHa therapy to the other patient. The peritoneal inclusion cysts failed to shrink in only one patient.


CONCLUSIONS
It is suggested that Gn-RHa therapy is effective in some cases of peritoneal inclusion cysts.
Nozawa
S
S
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Iwata
T
T
Yamashita
H
H
Banno
K
K
Kubushiro
K
K
Aoki
R
R
Tsukazaki
K
K
D000328:Adult; D002064:Buserelin / Q000627:therapeutic use*; D003560:Cysts / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D005836:Genitalia, Female / Q000601:surgery*; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000601:surgery; D016729:Leuprolide / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010052:Ovariectomy; D010532:Peritoneal Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011183:Postoperative Complications; D012008:Recurrence; D016896:Treatment Outcome; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000601:surgery
D016729:Leuprolide; D002064:Buserelin