Th1 T-cell and monocyte defects.
Mutations predisposing to infections with intracellular pathogens and affecting Th1 T-cells and monocytes have been identified in the past few years. In this article, the authors review the interaction of T cells and monocytes in the context of host defense against intracellular pathogens. Known genetic defects in these pathways are summarized.
Uzel
G
G
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. guzel@cc.nih.gov
Holland
S M
SM
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016260:Monocytes, Activated Killer / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*