title: Activated coagulation/fibrinolysis system and platelet function in acute thrombotic stroke patients with increased C-reactive protein levels.
abstract: The relationship between systemic infection or inflammation and an increased risk of thrombotic diseases has recently raised renewed interest. In order to determine the mechanisms underlying this relationship, we determined plasma levels of coagulation/fibrinolysis markers and platelet function in patients with acute thrombotic stroke (<24 h after onset) prior to treatment, and compared the results between cases with elevated and normal C-reactive protein (CRP) levels and controls. Plasma levels of thrombin-antithrombin complex (TAT), plasmin-antiplasmin complex, and D-dimer were significantly higher in patients with elevated CRP levels than in those with normal CRP levels and controls (P<0.005). Platelet aggregation induced by 1 and 10 microM ADP was significantly higher in patients with elevated CRP levels than those with normal CRP levels (P<0.05). These findings suggest that activation of the coagulation/fibrinolysis system and platelet function may be in part related to stroke onset in patients with increased CRP levels.
authors.affiliation: Department of Neurology, Iwate Medical University, 19-1 Uchimaru, Iwate 027-8505, Morioka, Japan. htohgi@iwate-med.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Tohgi
authors.forename: S
authors.initials: S
authors.lastname: Konno
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: D
authors.initials: D
authors.lastname: Koizumi
authors.forename: R
authors.initials: R
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000208:Acute Disease; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D020521:Stroke / Q000097:blood* / Q000503:physiopathology*
chemical_list: D002097:C-Reactive Protein