Triglycerides and coronary heart disease: implications of recent clinical trials.
This paper reviews the clinical trial data that offer insight into the question of whether, and in what groups of people, triglycerides might be an appropriate therapeutic target for the primary or secondary prevention of atherosclerotic cardiovascular disease. Two angiographic trials (the Lopid Coronary Angiography Trial and the Bezafibrate Coronary Atherosclerosis Intervention Trial) and three clinical endpoint trials (the Helsinki Heart Study, the Bezafibrate Infarction Prevention Study, and the VA HDL Intervention Trial) are reviewed. Hypertriglyceridemia per se is probably not an appropriate therapeutic target for the prevention of atherosclerotic cardiovascular disease because it is a poor marker of atherogenic risk and because there have been no clinical trials that have directly addressed the question of whether lowering the triglyceride level reduces the number of clinical events. The studies reviewed here, however, suggest that patients with established coronary heart disease and a high triglyceride level, in association with either a low high-density lipoprotein-cholesterol level or perhaps other features of the metabolic syndrome, such as obesity, diabetes, or hypertension, may benefit from fibrate therapy. For patients without established coronary heart disease, it is reasonable to consider hypertriglyceridemia as a risk marker prompting the aggressive treatment of other risk factors such as hypertension, diabetes, high low-density lipoprotein-cholesterol, and obesity.
Rubins
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Center for Chronic Disease Outcomes Research, Minneapolis VA Medical Center, Minneapolis, Minnesota 55417, USA. BLOOM013@tc.umn.edu
D000368:Aged; D001629:Bezafibrate / Q000627:therapeutic use*; D018849:Controlled Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D005260:Female; D015248:Gemfibrozil / Q000627:therapeutic use*; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy* / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016896:Treatment Outcome; D014280:Triglycerides / Q000378:metabolism*
D000960:Hypolipidemic Agents; D014280:Triglycerides; D015248:Gemfibrozil; D001629:Bezafibrate