Successful haploidentical bone marrow transplantation in Fanconi anemia.
A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available.
Elhasid
R
R
Department of Pediatric Hemato-Oncology, Rambam Medical Center and Technion, Haifa, Israel.
Ben Arush
M W
MW
Katz
T
T
Gan
Y
Y
Shechter
Y
Y
Sami
I
I
Postovsky
S
S
Reisner
Y
Y
Rowe
J M
JM
D018952:Antigens, CD34 / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods; D002648:Child; D005199:Fanconi Anemia / Q000628:therapy*; D005220:Fathers; D005260:Female; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D018189:Immunomagnetic Separation; D019520:Living Donors; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes / Q000276:immunology
D018952:Antigens, CD34; D006680:HLA Antigens