title: Hypertrophic chronic pachymeningitis as a localized immune process in the craniocervical region.
abstract: Hypertrophic chronic pachymeningitis (HCP) is a rare disorder that causes intracranial or spinal thickening of the dura mater. This report describes a patient with progressive HCP in the craniocervical region associated with signs of rheumatic disease. A ventricular-atrial shunt had to be inserted because of increased intracranial pressure. The patient improved after suboccipital craniotomy, C1 to C6 laminectomy, and removal of the thickened dura. Additional therapy with methotrexate stopped progression, which was documented by MRI and PET.
authors.affiliation: Department of Neurology, University of Vienna, Austria. bernhard.voller@akh-wien.ac.at
authors.forename: B
authors.initials: B
authors.lastname: Voller
authors.forename: K
authors.initials: K
authors.lastname: Vass
authors.forename: J
authors.initials: J
authors.lastname: Wanschitz
authors.forename: K
authors.initials: K
authors.lastname: Machold
authors.forename: S
authors.initials: S
authors.lastname: Asenbaum
authors.forename: M
authors.initials: M
authors.lastname: Hoberstorfer
authors.forename: E
authors.initials: E
authors.lastname: Auff
mesh_terms: D002557:Cerebrospinal Fluid Shunts; D002574:Cervical Vertebrae; D002908:Chronic Disease; D004388:Dura Mater / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D014055:Tomography, Emission-Computed
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate