Synthesis of a highly hydrophobic dimeric Lewis X containing glycolipid: a model for the study of homotypic carbohydrate--carbohydrate interaction.
This paper describes the synthesis of an octasaccharidic glycolipid 1 based on a stereo- and regioselective glycosylation between a Lewis X trisaccharidic donor and a pentasaccharidic acceptor. A highly hydrophobic lipid moiety of a new type was selected, making the compound 1 a good candidate for the study of the interaction of Lewis X functionalised vesicles.
Bregant
S
S
Ecole Normale Supérieure, Département de Chimie, CNRS UMR 8642, Paris, France.
Zhang
Y
Y
Mallet
J M
JM
Brodzki
A
A
Sinaÿ
P
P
D002240:Carbohydrate Sequence; D019281:Dimerization; D006017:Glycolipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D016256:Lewis X Antigen / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008969:Molecular Sequence Data; D015394:Molecular Structure
D006017:Glycolipids; D016256:Lewis X Antigen