title: Determination of specific radioactivity for (76)Br-labeled compounds measuring the ratio between (76)Br and (79)Br using packed capillary liquid chromatography mass spectrometry.
abstract: Packed capillary liquid chromatography with electrospray mass spectrometry was used for direct determination of the specific radioactivity by calculation of isotope ratios between the (76)Br- and (79)Br-labeled analogues of N-((3-aminomethyl)benzyl)-4-bromobenzamide. Using 20 microL injections on packed capillary columns, sufficient mass sensitivity was attained for the determination on an injected amount of radioactivity corresponding to approximately 2 MBq (0.3 pmol of the (76)Br isotopic analogue).
authors.affiliation: Department of Analytical Chemistry, Institute of Chemistry, Uppsala University, Uppsala, Sweden.
authors.forename: B H
authors.initials: BH
authors.lastname: Forngren
authors.forename: U
authors.initials: U
authors.lastname: Yngve
authors.forename: T
authors.initials: T
authors.lastname: Forngren
authors.forename: B
authors.initials: B
authors.lastname: Långström
mesh_terms: D001549:Benzamides / Q000737:chemistry; D001966:Bromine / Q000032:analysis*; D001967:Bromine Radioisotopes; D002853:Chromatography, Liquid; D007202:Indicators and Reagents; D013058:Mass Spectrometry
chemical_list: D001549:Benzamides; D001967:Bromine Radioisotopes; D007202:Indicators and Reagents; C422196:N-((3-aminomethyl)benzyl)-4-bromobenzamide; D001966:Bromine