title: Molecular characterization and phylogenetic analyses of a new simian T cell lymphotropic virus type 1 in a wild-caught african baboon (Papio anubis) with an indeterminate STLV type 2-like serology.
abstract: STLV-1 viruses are closely related to HTLV-1 and infect many African monkey species. Seroreactivities of monkeys infected by STLV-1 are nearly identical to those of HTLV-1-infected individuals. In some cases, STLV-1 are, sequence-wise, indistinguishable from HTLV-1, and cannot be separated from them on the basis of phylogenetic analyses. HTLV-2-related simian viruses have been rarely reported. Such STLV-2 viruses, present in African bonobo (Pan paniscus), possess a genomic organization related to but different from all known HTLV-2 subtypes. We report here the molecular characterization and the subtyping of a new STLV-1 in a wild-caught baboon (Papio anubis) whose serum exhibited an indeterminate STLV-2-like serology (p24, GD21, MTA-1 with no p19). In the env and LTR regions, this virus is phylogenetically related to the large African STLV-1 group, but does not cluster with any STLV-1 baboon sequence. The complete p19 sequence reveals amino acid changes at critical positions. This is the first report of an African STLV-1 virus leading to an STLV-2-like serological profile in its host.
authors.affiliation: Unité d'Oncologie Virale, Institut Pasteur, 75724 Paris cedex 15, France. rmahieux@pasteur.fr
authors.forename: R
authors.initials: R
authors.lastname: Mahieux
authors.forename: C
authors.initials: C
authors.lastname: Chappey
authors.forename: L
authors.initials: L
authors.lastname: Meertens
authors.forename: P
authors.initials: P
authors.lastname: Mauclère
authors.forename: J
authors.initials: J
authors.lastname: Lewis
authors.forename: A
authors.initials: A
authors.lastname: Gessain
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000835:Animals, Wild; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000737:chemistry; D000939:Epitopes; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000821:virology*; D010215:Papio / Q000821:virology*; D010802:Phylogeny; D012192:Retroviridae Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D015303:Simian T-lymphotropic virus 1 / Q000145:classification* / Q000235:genetics / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes