title: Study of immune response in pigs fed with high vitamin E-dosages.
abstract: The effects of long-term vitamin E-supplementation on phagocytic cells, lymphocyte sub-populations, and SWC3+ cell count were studied in pigs. Eighteen weaned pigs were divided into three groups: 1) 100 mg DL-alpha tocopheryl acetate/kg diet, 2) 200 mg DL-alpha tocopheryl acetate/kg diet, 3) control group (basic feed with 10 mg DL-alpha tocopheryl acetate/kg diet). The examination of the immune indices was performed on day 120 of feeding the supplemented diets. The higher dietary levels of vitamin E resulted in increased serum concentration of alpha-tocopherol for both experimental groups (p < 0.05) and there were no significant differences in counts of CD2+, CD4+, CD8+, B lymphocytes nor SWC3+ cells among the groups. Similarly, vitamin E supplementation did not affect the functions of phagocytic cells tested.
authors.affiliation: Department of Internal Diseases of Ruminants and Swine, University of Veterinary Medicine, Kosice.
authors.forename: P
authors.initials: P
authors.lastname: Mudron
authors.forename: M
authors.initials: M
authors.lastname: Levkut
authors.forename: V
authors.initials: V
authors.lastname: Revajová
authors.forename: G
authors.initials: G
authors.lastname: Kovác
mesh_terms: D000821:Animal Feed; D000818:Animals; D019587:Dietary Supplements; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D010586:Phagocytes / Q000166:cytology* / Q000187:drug effects; D013552:Swine; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols