title: [Cell cycle transformation in cell differentiation].
abstract: A question was posed as to how the multicomponent and polyfunctional organelle dynamically changes during metazoan ontogenesis. The centrosome structure is gradually formed and its functions are switched on during early embryogenesis, one of which is the cell center formation. During cell differentiation, the condition of the cell center and surrounding structures may be different: first, the cell center is quite distinct; second, the cell center is absent due to redistribution of the centers of microtubule organization; third, the cell center disappears due to reversible or irreversible inactivation of the centrosome and other centers of microtubule organization. The assembly of the common Golgi complex is not directed directly to the cell center presence. In some cell types, the Golgi complex is topologically associated with the cell center, while in others it is represented by individual dictyosomes despite the cell center presence. In some other cell types, the common Golgi complex is assembled without the cell center, but in the presence of microtubules that are formed by noncentrosome centers of microtubule organization. In still others, degradation of both the cell center and the common Golgi complex takes place in the case of centrosome inactivation.
authors.affiliation: Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
authors.forename: G E
authors.initials: GE
authors.lastname: Onishchenko
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D015388:Organelles / Q000502:physiology* / Q000648:ultrastructure