title: The use of lepirudin for anticoagulation in patients with heparin-induced thrombocytopenia during major vascular surgery.
abstract: The method of anticoagulation in patients undergoing major vascular surgery with a history of heparin-induced thrombocytopenia (HIT) is controversial. We present two cases in which a bolus only technique using recombinant hirudin (Lepirudin or Refludan) was used successfully in patients with HIT scheduled for vascular surgery.
authors.affiliation: Department of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: P E
authors.initials: PE
authors.lastname: Greilich
authors.forename: S I
authors.initials: SI
authors.lastname: Wilson
authors.forename: M R
authors.initials: MR
authors.lastname: Jackson
authors.forename: C W
authors.initials: CW
authors.lastname: Whitten
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D006493:Heparin / Q000009:adverse effects*; D006629:Hirudins / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011994:Recombinant Proteins / Q000494:pharmacology*; D013921:Thrombocytopenia / Q000139:chemically induced*; D014656:Vascular Surgical Procedures
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; D006493:Heparin; C083544:lepirudin