Effects of a hydrolyzed collagen dressing on the healing of open wounds in dogs.
OBJECTIVE
To determine the effects of a hydrolyzed bovine collagen dressing (HBCD) on healing of open wounds in healthy dogs.


METHODS
9 female Beagles.


METHODS
2 full-thickness skin wounds were made bilaterally on the trunk of each dog. Wounds on 1 side were treated with powdered HBCD covered with a semiocclusive nonadherent bandage. Wounds on the other side (control wounds) were covered with a semiocclusive nonadherent bandage only. Wound healing was subjectively assessed, and percentage increase in tissue perfusion was assessed by use of laser Doppler perfusion imaging (LDPI). Planimetry was performed to determine the percentages of contraction, epithelialization, and total wound healing. Biopsy specimens were examined microscopically to evaluate histologic changes.


RESULTS
The HBCD did not induce a strong inflammatory reaction, as reflected by results of LDPI and histologic examination. Moreover, HBCD appeared hydrophilic and provided an environment to keep wounds clean and enhance early epithelialization. After treatment for 7 days, treated wounds had a significantly greater percentage of epithelialization than control wounds (12.13 vs. 7.03%).


CONCLUSIONS
The hydrophilic property of HBCD may cleanse contaminated wounds with the body's homeostatic fluids and enhance early wound epithelialization.
Swaim
S F
SF
Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, AL 36849, USA.
Gillette
R L
RL
Sartin
E A
EA
Hinkle
S H
SH
Coolman
S L
SL
D000818:Animals; D002417:Cattle; D003094:Collagen; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D009779:Occlusive Dressings; D012867:Skin / Q000293:injuries; D018608:Ultrasonography, Doppler; D014945:Wound Healing; D014947:Wounds and Injuries / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*
D003094:Collagen