title: Clinical efficacy of pneumococcal vaccination--a prospective study in patients with longstanding emphysema and/or bronchitis.
abstract: In a prospective study the clinical effectiveness of pneumococcal vaccination was evaluated over a 12 months period and compared to a respective analysis of respiratory tract infections in the same patient population. Of 65 enrolled patients with severe and longstanding emphysema and/or chronic bronchitis 52 patients completed the study. One year after vaccination with pneumococcal vaccine in its 23-valent form the incidence of bacterial bronchitis or pneumonia averaged 28 %. As compared to a 12 months period prior vaccination the rate of pneumonia but not of bronchitis was significantly reduced.
authors.affiliation: Pneumologisch-kardiologische Praxis, Cologne, Germany. Franzen.Damian@t-online.de
authors.forename: D
authors.initials: D
authors.lastname: Franzen
mesh_terms: D000368:Aged; D001991:Bronchitis / Q000382:microbiology*; D002908:Chronic Disease; D004646:Emphysema / Q000382:microbiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000627:therapeutic use*; D011018:Pneumonia, Pneumococcal / Q000517:prevention & control*; D011446:Prospective Studies; D012189:Retrospective Studies; D013296:Streptococcus pneumoniae
chemical_list: D022242:Pneumococcal Vaccines