title: Can percutaneous endoscopic jejunostomy prevent gastroesophageal reflux in patients with preexisting esophagitis?
abstract: OBJECTIVE
  Percutaneous endoscopic jejunostomy has been used for preventing pulmonary aspiration arising from gastric contents by concomitant jejunal feeding and gastric decompression in susceptible patients. Our objective was to evaluate gastroesophageal reflux in patients with percutaneous endoscopic jejunostomy tube feeding.
  
  
  METHODS
  Eight cerebrovascular accident patients with percutaneous endoscopic jejunostomy tube placement caused by reflux esophagitis with hematemesis, food regurgitation or vomiting, and/or recurrent aspiration pneumonia were tested for gastroesophageal reflux using 24-h esophageal pH monitoring during continuous jejunal liquid meal or saline infusion with concomitant gastric decompression. Twenty-four hour pH monitoring was also performed during intragastric feeding on a different day.
  
  
  RESULTS
  During the liquid meal feeding period, percutaneous endoscopic jejunostomy feeding reduced esophageal acid exposure 46% [12.9% (4.9-28.2%) versus 24.0% (19.0-40.6%), p = 0.01], compared to intragastric feeding. However, in the period of the jejunal tube infusion, esophageal acid exposure was significantly lower during saline infusion than during meal infusion [3.2 (0.0%-10.8%) versus 12.9% (4.9-28.2%), p = 0.008].
  
  
  CONCLUSIONS
  Percutaneous endoscopic jejunostomy feeding reduced but did not eliminate gastroesophageal reflux, compared to intragastric feeding in patients with severe gastroesophageal reflux. However, gastroesophageal reflux during percutaneous jejunal feeding was associated with meal infusion. This might, in part, explain the failure of percutaneous endoscopic jejunostomy tube placement to prevent pulmonary aspiration.
authors.affiliation: Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan.
authors.forename: H C
authors.initials: HC
authors.lastname: Lien
authors.forename: C S
authors.initials: CS
authors.lastname: Chang
authors.forename: G H
authors.initials: GH
authors.lastname: Chen
mesh_terms: D000368:Aged; D004750:Enteral Nutrition; D004942:Esophagitis, Peptic / Q000150:complications*; D005526:Food, Formulated; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007582:Jejunostomy / Q000379:methods; D008297:Male; D008991:Monitoring, Physiologic; D011015:Pneumonia, Aspiration / Q000517:prevention & control; D020521:Stroke / Q000150:complications