title: Synthesis of (3alpha,7beta,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol, a metabolite of ORG OD14, and its 7-epimer.
abstract: The syntheses of the 7beta-hydroxy metabolite of ORG OD14 (Livial((R))), (3alpha,7beta,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol (35), and its 7-epimer, (3alpha,7alpha,17alpha)-7-methyl-19-norpregn-5(10)-en-20-yne-3,7,17-triol (11), are described.
authors.affiliation: Medicinal Chemistry Department, N.V. Organon, P.O. Box 20, 5340, BH Oss, The Netherlands. R.Plate@organon.oss.akzonobel.nl
authors.forename: R
authors.initials: R
authors.lastname: Plate
authors.forename: R C
authors.initials: RC
authors.lastname: van Wuijtswinkel
authors.forename: C G
authors.initials: CG
authors.lastname: Jans
authors.forename: M B
authors.initials: MB
authors.lastname: Groen
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009652:Norpregnenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D009652:Norpregnenes; C027385:tibolone