Single-dose pharmacokinetics of levofloxacin during continuous veno-venous haemofiltration in critically ill patients.
The present study was performed to analyse the pharmacokinetics of levofloxacin during continuous veno-venous haemofiltration (CVVH) with a high-flux polyamide membrane. Twelve patients received 500 mg levofloxacin intravenously. The mean levofloxacin concentration peak was 1.9 +/- 1.0 mg/L. The elimination half-life, haemofiltration clearance and total removal were 8.3 +/- 2.6 h, 27.6 +/- 8.4 mL/min and 56 +/- 19%, respectively. Further multiple-dose studies are required to enable dosage recommendations to be made for patients receiving renal replacement therapy with CVVH.
Traunmüller
F
F
Division of Infectious Diseases, Department of Internal Medicine I, University of Vienna, Austria.
Thalhammer-Scherrer
R
R
Locker
G J
GJ
Losert
H
H
Schmid
R
R
Staudinger
T
T
Thalhammer
F
F
D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D003422:Critical Care; D005260:Female; D006207:Half-Life; D006440:Hemofiltration; D006801:Humans; D007275:Injections, Intravenous; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin