Effect of fensuccinal on experimental insulin resistance.
The effects of new antioxidant fensuccinal on dexamethasone-induced insulin resistance in rats were studied. Oral administration of fensuccinal in a dose of 25 mg/kg for 2 weeks prevented basal hyperinsulinemia and insulin insensitivity of peripheral tissues. Fensuccinal also attenuated oxidative stress by decreasing the concentrations of primary and secondary lipid peroxidation products in liver homogenates. The ability of fensuccinal to prevent dexamethasone-induced insulin resistance is probably due to its antioxidant properties.
Gorbenko
N I
NI
Laboratory of Pathophysiology, Ukrainian Institute of Pharmacotherapy of Infectious Diseases, Kharkov. fez@email.itl.net.ua
Poltorak
V V
VV
Gladkikh
A I
AI
Ivanova
O V
OV
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D003907:Dexamethasone / Q000009:adverse effects; D007333:Insulin Resistance; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000447:Aldehydes; D000975:Antioxidants; D001786:Blood Glucose; C419904:fensuccinal; D003907:Dexamethasone