Carcinoids of the ovary: an analysis of 329 reported cases.
This evaluation was undertaken to supply precise and reliable detailed information to investigators actively working in carcinoid and related gynecological research fields. A statistical evaluation was performed on 329 cases of ovarian carcinoid registered in the Niigata Registry where world-wide information of gut-pancreatic endocrinomas has been maintained by a computer-analyzing system. Cases without individual identification or those recorded in groups were excluded. The evaluation was carried out mainly by a comparison between two groups of cases with cystic teratoma/dermoid (Group A) and those without such lesions (Group B). The former group consisted of 189 cases (57.4%) and the latter of 140 (42.6%). Statistically significant differences between these two groups were recognized in tumor size (44.7 mm vs 89.8 mm), rate of metastases (5.8% vs 22.1%), rate of hepatic involvement (2.1% vs 15.0%), incidence of associated carcinoid syndrome (13.8% vs 22.9%) and 5-year survival rate (93.7% vs 84.0%). Insular type and trabecular type carcinoids were recorded at an almost equal rate of one fourth ranging between 22% and 26% in either group. Another significant difference in the incidence of carcinoid syndrome was evident between the series of insular type and trabecular type carcinoids (38.9% vs 7.8%). The present evaluation on ovarian carcinoids disclosed definite, statistically significant differences in various clinical and pathophysiologic aspects between Group A and Group B, as well as between insular type and trabecular type histologic structures.
Soga
J
J
Niigata Seiryo University, Niigata City, Japan. soga@n-seiryo.ac.jp
Osaka
M
M
Yakuwa
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002276:Carcinoid Tumor / Q000453:epidemiology / Q000473:pathology*; D003884:Dermoid Cyst / Q000453:epidemiology / Q000473:pathology; D003937:Diagnosis, Differential; D019858:Enteroendocrine Cells / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000473:pathology*; D016622:Silver Staining; D015996:Survival Rate; D013724:Teratoma / Q000453:epidemiology / Q000473:pathology