Insights into the biologic and molecular abnormalities in adult acute lymphocytic leukemia.
The last 3 decades have seen much progress in the treatment and outcome of patients with ALL. Unfortunately, the success that has been achieved in children with ALL has not yet been translated into adult patients. Insight into the biologic and molecular abnormalities in ALL may, however, provide the necessary clues that allow a clearer understanding of the crucial differences in the behavior of ALL in different groups of patients. As the molecular basis of the disease is deciphered, new targets are discovered that may prove useful for therapeutic interventions in the future.
Faderl
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Department of Leukemia, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Albitar
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D000328:Adult; D000367:Age Factors; D000782:Aneuploidy; D001260:Ataxia Telangiectasia / Q000235:genetics; D064007:Ataxia Telangiectasia Mutated Proteins; D002448:Cell Adhesion / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics; D018797:Cell Cycle Proteins; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics / Q000648:ultrastructure; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics / Q000648:ultrastructure; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics / Q000648:ultrastructure; D050676:Core Binding Factor Alpha 2 Subunit; D004249:DNA Damage; D004268:DNA-Binding Proteins; D016044:Fusion Proteins, bcr-abl / Q000235:genetics / Q000502:physiology; D011905:Genes, ras; D006801:Humans; D019656:Loss of Heterozygosity; D009389:Neovascularization, Pathologic / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins; D000097764:ETS Translocation Variant 6 Protein
D064007:Ataxia Telangiectasia Mutated Proteins; D015815:Cell Adhesion Molecules; D018797:Cell Cycle Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D016044:Fusion Proteins, bcr-abl; D015514:Oncogene Proteins, Fusion; D017346:Protein Serine-Threonine Kinases; D025521:Tumor Suppressor Proteins; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein; C576324:ATM protein, human