A new NPY-antagonist strongly stimulates apoptosis and lipolysis on white adipocytes in an obesity model.
Neuropeptide Y (NPY) is a 36 amino acid peptide released in central and peripheral mammalian neurons, which appears to contribute to adiposity regulation by increasing food intake, thus promoting weight gain on animals. Nevertheless, little is known about NPY direct actions on white adipocytes. This trial, which was designed to test the possible effects of a new NPY antagonist, S.A.0204, on white adipose tissue, revealed that the administration of this novel molecule strongly ex vivo stimulates apoptosis and lipolysis in animals fed on a high-fat diet.
Margareto
J
J
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
Aguado
M
M
Osés-Prieto
J A
JA
Rivero
I
I
Monge
A
A
Aldana
I
I
Marti
A
A
Martínez
J A
JA
D017667:Adipocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001831:Body Temperature; D004195:Disease Models, Animal; D005247:Feeding Behavior / Q000187:drug effects; D005260:Female; D008066:Lipolysis / Q000187:drug effects*; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors*; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D009478:Neuropeptide Y