Antioxidant activity and xanthine oxidase inhibition activity of reductic acid: ascorbic acid analogue.
Reductic acid (2,3-dihydroxy-2-cyclopentenone, 1) decreased the ESR signal of 5,5-dimethyl-1-pyrroline 1-oxide (DMPO)-OH produced by hydroxyl radical and DMPO. 1 also inhibited lipid peroxidation initiated by cytochrome P450 and tert-butyl hydroperoxide. 1 inhibited xanthine oxidase activity, while ascorbic acid and 2-hydroxytetronic acid, an ascorbic acid analogue without side chain, did not.
Mashino
T
T
Kyoritsu College of Pharmacy, Tokyo, Japan.
Takigawa
Y
Y
Saito
N
N
Wong
L Q
LQ
Mochizuki
M
M
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000378:metabolism; D001205:Ascorbic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D003517:Cyclopentanes / Q000037:antagonists & inhibitors* / Q000138:chemical synthesis; D065607:Cytochrome P-450 Enzyme Inhibitors; D004305:Dose-Response Relationship, Drug; D004578:Electron Spin Resonance Spectroscopy; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013997:Time Factors; D014969:Xanthine Oxidase / Q000378:metabolism* / Q000494:pharmacology
D000975:Antioxidants; D003517:Cyclopentanes; D065607:Cytochrome P-450 Enzyme Inhibitors; C064295:reductic acid; D014969:Xanthine Oxidase; D001205:Ascorbic Acid