[The role of leukotrienes and the effect of leukotriene receptor antagonists in allergic rhinitis].
Allergic rhinitis is associated with persistent inflammation of nasal mucosa. Characteristic feature of this inflammation is an accumulation of eosinophils. These cells are the major source of cysteinyl leukotrienes--potent pro-inflammatory mediators responsible for nasal blockade, rhinorrhoea and hyperresponsiveness. Because leukotriene receptor antagonists inhibit activity of endogenous leukotrienes and decrease tissue eosinophilia it is speculated that these drugs may be useful also in the management of allergic rhinitis. This article is an overview of the publication on the role of leukotrienes in allergic rhinitis and the effect of leukotriene receptor antagonists.
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Kliniki Pneumonologii i Alergologii AM w Łodzi.
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D006801:Humans; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D015289:Leukotrienes / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000378:metabolism*
D020024:Leukotriene Antagonists; D015289:Leukotrienes