title: Effect of secretin on children with autism: a randomized controlled trial.
abstract: To determine the effect of intravenous porcine secretin on autistic behaviours in children aged 2 to 7 years, the effects of secretin on (1) performance on a standardized language measure, and (2) autistic behaviours, as rated by parents and child development professionals was examined. Employing a randomized, double-blind, placebo-controlled design, 95 participants were assigned to one of two groups and administered a single dose of either secretin or placebo. A follow-up assessment was conducted 3 weeks after the injection. No significant differences in language or autistic behaviour measures were observed at the 3-week follow-up between the groups. Also, there was no significant difference in the proportion of individuals who improved by > or = 6 points on the language measure at follow-up. This study showed no significant effects of secretin on children with autism. Our results are consistent with a systematic review of randomized controlled trials evaluating the effect of secretin in children with autism.
authors.affiliation: Child Development Service, Children's Hospital of Eastern Ontario, Ottawa, Canada. dunngeier@cheo.on.ca
authors.forename: J
authors.initials: J
authors.lastname: Dunn-Geier
authors.forename: H H
authors.initials: HH
authors.lastname: Ho
authors.forename: E
authors.initials: E
authors.lastname: Auersperg
authors.forename: D
authors.initials: D
authors.lastname: Doyle
authors.forename: L
authors.initials: L
authors.lastname: Eaves
authors.forename: C
authors.initials: C
authors.lastname: Matsuba
authors.forename: E
authors.initials: E
authors.lastname: Orrbine
authors.forename: B
authors.initials: B
authors.lastname: Pham
authors.forename: S
authors.initials: S
authors.lastname: Whiting
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D003071:Cognition; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007802:Language; D008297:Male; D012633:Secretin / Q000494:pharmacology* / Q000627:therapeutic use; D013552:Swine; D016896:Treatment Outcome
chemical_list: D012633:Secretin