title: Factors influencing total dietary exposures of young children.
abstract: A deterministic model was developed to identify the critical input parameters needed to assess dietary intakes of young children. The model was used as a framework for understanding the important factors in data collection and data analysis. Factors incorporated into the model included transfer efficiencies of pesticide from surfaces to food, transfer efficiencies of pesticide from surfaces to hands to food, and more accurate microactivity data related to contact frequency for the three variables of interest--hands, surfaces, and food. Results from range-finding measurements of transfer efficiencies using an aqueous pesticide solution of a mixture of malathion, diazinon, and chlorpyrifos sprayed on the surfaces indicate that a higher pesticide transfer occurred from hard surfaces to food (hardwood, plastic), with low transfer from soft surfaces (carpet, cloth). Six children, all less than 4 years old, were videotaped to obtain realistic contact frequency and times for the interaction of hands, surfaces, and foods during eating meals and snacks while in their homes or day care centers. The time range of eating events varied from about 2 to 55 min, with an average of about 20 min. The average number of contact frequencies between food and hands was 19 times for each eating event, with a range of 10-40. Contacts between the surface and hand were about the same as the food and hands. Contacts between foods and surfaces ranged from 0 to 32, but only five or less of the contacts per eating event were associated with surfaces other than eating utensil. The children's microactivity data collected during the eating events, together with the laboratory results from the transfer studies, were provided as input into a Monte Carlo simulation of the dietary ingestion model. Simulation results indicate that children's handling of the food could contribute 20-80% of the total dietary intake of pesticides. Dietary exposure due to residues in the food before handling accounted for 16% and 47%, respectively, of the total mean intake from simulations for a child's consumption of an apple or banana. These results indicated that transfer efficiencies for foods on various surfaces typically found in homes as well as children's hand contacts with the food and surfaces are important as determinants of dietary exposure.
authors.affiliation: Research Triangle Institute, Research Triangle Park, North Carolina 27709-2194, USA. akland@rti.org
authors.forename: G G
authors.initials: GG
authors.lastname: Akland
authors.forename: E D
authors.initials: ED
authors.lastname: Pellizzari
authors.forename: Y
authors.initials: Y
authors.lastname: Hu
authors.forename: M
authors.initials: M
authors.lastname: Roberds
authors.forename: C A
authors.initials: CA
authors.lastname: Rohrer
authors.forename: J O
authors.initials: JO
authors.lastname: Leckie
authors.forename: M R
authors.initials: MR
authors.lastname: Berry
mesh_terms: D002675:Child, Preschool; D003625:Data Collection / Q000379:methods; D004032:Diet; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000032:analysis*; D005260:Female; D005506:Food Contamination; D005511:Food Handling; D006801:Humans; D007223:Infant; D008297:Male; D008962:Models, Theoretical; D010573:Pesticide Residues / Q000032:analysis*; D013997:Time Factors; D014741:Video Recording
chemical_list: D004785:Environmental Pollutants; D010573:Pesticide Residues