Effects of nitric oxide donors on the retinal function measured with electroretinography.
It has been reported that nitric oxide raises c-GMP in the vascular muscle to cause vasodilation and to improve blood flow in the retina. Consequently, a diverse group of potential nitric oxide (NO) donors were synthesized and evaluated for their effectiveness in improving the retinal function after ischemic insult. These compounds include an NO carrier, N-acetyl-S-nitrosoglutathione (RVC-593), several NO donors such as N-nitropyrazole derivatives (RVC-595, RVC-596, RVC-597, RVC-598, and RVC-599) and two fused N-heterocycles, 4H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxides, (RVC-600 and RVC-601). Most of the compounds demonstrated the pharmacological activity in the ophthalmic model, except the pyrazole derivatives (RVC-595, RVC-596 and RVC-599) that bear bulky aromatic substituents at the R2-position.
Varma
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RS
Department of Chemistry, Sam Houston State University, Huntsville, Texas, USA.
Xuan
B
B
Chiou
G C
GC
D000818:Animals; D019842:Ciliary Arteries / Q000503:physiopathology; D006152:Cyclic GMP / Q000378:metabolism; D003623:Dark Adaptation; D004596:Electroretinography; D005260:Female; D007274:Injections, Intraperitoneal; D007511:Ischemia / Q000503:physiopathology*; D009569:Nitric Oxide / Q000378:metabolism; D020030:Nitric Oxide Donors / Q000138:chemical synthesis / Q000494:pharmacology*; D010775:Photic Stimulation; D051381:Rats; D020318:Rats, Long-Evans; D020127:Recovery of Function; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D012171:Retinal Vessels / Q000503:physiopathology; D014664:Vasodilation / Q000187:drug effects
D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D006152:Cyclic GMP