title: Activity-guided isolation of antioxidative constituents of Cotinus coggygria.
abstract: Six constituents (1-6) were isolated from EtOAc-soluble partitions of two separate collections of the whole plants of Cotinus coggygria, namely, disulfuretin ¿2,2'-[1,2-bis(3,4-dihydroxyphenyl)-1, 2-ethanedylidene]bis[6-hydroxy-3(2H)-benzofuranone] (1)¿, sulfuretin (2), sulfurein (3), gallic acid (4), methyl gallate (5), and pentagalloyl glucose (6). The structure of the novel biaurone 1 was determined by spectral and chemical methods. Compounds 1-6 were found to be potent antioxidants in a 1,1-diphenyl-2-picrylhydrazyl free-radical scavenging assay.
authors.affiliation: Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 60612, USA.
authors.forename: H E
authors.initials: HE
authors.lastname: Westenburg
authors.forename: K J
authors.initials: KJ
authors.lastname: Lee
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
authors.forename: H H
authors.initials: HH
authors.lastname: Fong
authors.forename: R B
authors.initials: RB
authors.lastname: van Breemen
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D013057:Spectrum Analysis
chemical_list: D000975:Antioxidants