Two cases of autoimmune neutropenia possibly induced by beta-lactam antibiotics in infants.
This report describes two infants who had neutropenia develop after treatment with beta-lactam antibiotics. The first patient, a 9-month-old girl, was administered flomoxef (FMOX); the second patient, a 14-month-old boy, was administered cefotiam (CTM). Both infants were found to have neutropenia 4 to 5 days after they were placed on respective antibiotics, and neutropenia had persisted despite antibiotics withdrawal for 1 to 3 months. Drug-induced lymphocyte stimulation test (DLST), granulocyte-bound antibodies, serum granulocyte antibodies, and immunoblotting analysis indicated that beta-lactam antibiotics possibly triggered production of granulocyte autoantibody with resultant autoimmune neutropenia.
Taniuchi
S
S
Department of Pediatrics, Kansai Medical University, Moriguchi, Osaka, Japan. taniuchi@takii.kmu.ac.jp
Masuda
M
M
Yamamoto
A
A
Hasui
M
M
Tsuji
S
S
Takahashi
H
H
Kobayashi
Y
Y
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000139:chemically induced*; D015310:Cefotiam / Q000009:adverse effects*; D002511:Cephalosporins / Q000009:adverse effects*; D005260:Female; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D066298:In Vitro Techniques; D007223:Infant; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009503:Neutropenia / Q000139:chemically induced* / Q000276:immunology*; D017452:Receptors, IgG / Q000097:blood
D000900:Anti-Bacterial Agents; D001323:Autoantibodies; D002511:Cephalosporins; D007074:Immunoglobulin G; D017452:Receptors, IgG; D015310:Cefotiam; C045693:flomoxef