title: Enantioselective synthesis of tert-butyl tert-butanethiosulfinate catalyzed by cyclohexanone monooxygenase.
abstract: Cyclohexanone monooxygenase from Acinetobacter calcoaceticus catalyzes the asymmetric oxidation of tert-butyl disulfide to enantiomerically pure (R)-tert-butyl tert-butanethiosulfinate. Lower enantioselectivities and conversions were observed in the oxidation of i-propyl, n-butyl, p-tolyl tert-butyl disulfides and alkylthiophosphonates.
authors.affiliation: Centro CNR and Istituto di Chimica Organica, Facoltà di Farmacia, Milano, Italy. Colonna@mailserver.unimi.it
authors.forename: S
authors.initials: S
authors.lastname: Colonna
authors.forename: N
authors.initials: N
authors.lastname: Gaggero
authors.forename: G
authors.initials: G
authors.lastname: Carrea
authors.forename: P
authors.initials: P
authors.lastname: Pasta
authors.forename: V
authors.initials: V
authors.lastname: Alphand
authors.forename: R
authors.initials: R
authors.lastname: Furstoss
mesh_terms: D016954:Acinetobacter calcoaceticus / Q000201:enzymology; D002384:Catalysis; D010105:Oxygenases / Q000737:chemistry*; D013237:Stereoisomerism; D013451:Sulfonic Acids / Q000138:chemical synthesis*
chemical_list: D013451:Sulfonic Acids; C419650:tert-butyl tert-butanethiosulfinate; D010105:Oxygenases; C019961:cyclohexanone oxygenase