title: Short-term antibiotic prophylaxis for the prevention of wound infection and secondary meningitis in acoustic neuroma surgery: a ten-year experience in a regional hospital.
abstract: Wound infection and secondary meningitis are important complications for patients undergoing acoustic neuroma surgery. The Authors retrospectively evaluated the efficacy of a short-term protocol utilizing vancomycin and netilmicin. 434 patients underwent acoustic neuroma surgery in the Otorhinolaryngology Division, A.O. Ospedali Riuniti di Bergamo, from February 1987 to February 1997. Perioperative short-term prophylaxis was administered with vancomycin plus netilmicin. The utility of the prophylaxis schedule was evaluated on the basis of the occurrence of infectious episodes during the first 10-day follow-up. Only 2 episodes (0.5%) of bacterial meningitis were observed.
authors.affiliation: Infectious Disease Institute, A.O. Ospedali Riuniti di Bergamo, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Minola
authors.forename: C
authors.initials: C
authors.lastname: Farina
authors.forename: C
authors.initials: C
authors.lastname: Zappone
authors.forename: M
authors.initials: M
authors.lastname: Arosio
authors.forename: N
authors.initials: N
authors.lastname: Lorenzi
authors.forename: A
authors.initials: A
authors.lastname: Mazzoni
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016920:Meningitis, Bacterial / Q000453:epidemiology / Q000517:prevention & control*; D009428:Netilmicin / Q000627:therapeutic use*; D009464:Neuroma, Acoustic / Q000150:complications / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*; D014640:Vancomycin / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin; D014640:Vancomycin