Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma.
In situ distribution of three prototype chemokines interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1 and Rantes was determined in chronic human periapical granulomas by immunohistochemistry using monoclonal antibodies. IL-8 was found primarily in the cytoplasm of the Malassez epithelial cells. MCP-1 immunoreactivity was confined to the endothelial cells that lined small venules. Each of the three investigated chemokines, including Rantes, exhibited a characteristic binding pattern to the extracellular matrix of the lesion. The observed chemokines may play a role in establishing the cellular composition of chronic apical periodontitis, thus augmenting the intensity of local inflammation and tissue damage.
Marton
I J
IJ
Department of Restorative Dentistry, Institute of Stomatology, Medical School of the University of Debrecen, P.O. Box 13, H-4012 Debrecen, Hungary.
Rot
A
A
Schwarzinger
E
E
Szakáll
S
S
Radics
T
T
Vályi-Nagy
I
I
Kiss
C
C
D018932:Chemokine CCL2 / Q000032:analysis / Q000378:metabolism; D018946:Chemokine CCL5 / Q000032:analysis / Q000378:metabolism; D018925:Chemokines / Q000032:analysis / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D002908:Chronic Disease; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis / Q000378:metabolism; D010484:Periapical Granuloma / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology
D018932:Chemokine CCL2; D018946:Chemokine CCL5; D018925:Chemokines; D016209:Interleukin-8