title: Laryngeal sarcoidosis: treatment with the antileprosy drug clofazimine.
abstract: Sarcoidosis is a chronic systemic granulomatous disease that occasionally affects the larynx. When the larynx is affected, the symptoms are frequently mild, but severe airway obstruction can occur. Although systemic corticosteroids are helpful, patients may become refractory to further drug administration. The current methods of treatment are here summarized, and the patient literature is reviewed. We also report a case of a young patient suffering from laryngeal sarcoidosis successfully treated by the antileprosy agent clofazimine and propose it as an alternative treatment of laryngeal sarcoidosis in patients refractory to corticosteroids.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Albert-Ludwigs-University, Freiburg, Germany.
authors.forename: G J
authors.initials: GJ
authors.lastname: Ridder
authors.forename: H
authors.initials: H
authors.lastname: Strohhäcker
authors.forename: E
authors.initials: E
authors.lastname: Löhle
authors.forename: A
authors.initials: A
authors.lastname: Golz
authors.forename: M
authors.initials: M
authors.lastname: Fradis
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000209:etiology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001706:Biopsy; D002991:Clofazimine / Q000494:pharmacology / Q000627:therapeutic use*; D003680:Deglutition Disorders / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D006685:Hoarseness / Q000209:etiology; D006801:Humans; D007818:Laryngeal Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D007828:Laryngoscopy; D007917:Leprostatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D012891:Sleep Apnea Syndromes / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007917:Leprostatic Agents; D002991:Clofazimine; D011241:Prednisone