Occupational exposure to pesticides and pancreatic cancer.
BACKGROUND
An increased risk of exposure to pesticides for pancreatic cancer has been suggested in a number of epidemiologic studies.


METHODS
Cases (N = 484), aged 30-79 years, were diagnosed in 1986-1989. Controls (N = 2,095) were a random sample of the general population. Information on usual occupation and potential confounding factors was obtained. A job-exposure matrix (JEM) approach was used to estimate the level of occupational exposure to pesticides.


RESULTS
A significant trend in risk with increasing exposure level of pesticides was observed, with ORs of 1.3 and 1.4 for low and moderate/high exposure levels, respectively. Excess risks were found for occupational exposure to fungicides (OR = 1.5) and herbicides (OR = 1.6) in the moderate/high level after adjustment for potential confounding factors. An increased risk for insecticide exposure was disappeared after adjustment for fungicide and herbicide exposures. Results of our occupation-based analysis were consistent with those from the JEM-based analysis.


CONCLUSIONS
Our results suggest that pesticides may increase risk of pancreatic cancer, and indicate the need for investigations that can evaluate risk by specific chemical exposures. Published 2001 Wiley-Liss, Inc.
Ji
B T
BT
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. jib@exchange.nih.gov
Silverman
D T
DT
Stewart
P A
PA
Blair
A
A
Swanson
G M
GM
Baris
D
D
Greenberg
R S
RS
Hayes
R B
RB
Brown
L M
LM
Lillemoe
K D
KD
Schoenberg
J B
JB
Pottern
L M
LM
Schwartz
A G
AG
Hoover
R N
RN
D000328:Adult; D000368:Aged; D044383:Black People; D016022:Case-Control Studies; D016001:Confidence Intervals; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005659:Fungicides, Industrial / Q000009:adverse effects; D006540:Herbicides / Q000009:adverse effects; D006801:Humans; D007306:Insecticides / Q000009:adverse effects; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D010575:Pesticides / Q000009:adverse effects*; D011159:Population Surveillance; D012307:Risk Factors; D044465:White People
D005659:Fungicides, Industrial; D006540:Herbicides; D007306:Insecticides; D010575:Pesticides