Growth hormone hypersecretion in a girl with neurofibromatosis type 1 and an optic nerve glioma: resolution following chemotherapy.
Growth hormone hypersecretion is extremely rare in childhood. We report a girl with neurofibromatosis type 1, an extensive optic nerve glioma and growth hormone hypersecretion. She was treated with chemotherapy to prevent further extension of her sight-threatening tumour. Three years after chemotherapy her growth hormone hypersecretion has resolved although she has gone on to develop precocious puberty.
Drake
A J
AJ
Royal Hospital for Sick Children, Bristol, UK.
Lowis
S P
SP
Bouffet
E
E
Crowne
E C
EC
D000365:Age Determination by Skeleton; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001827:Body Height; D002675:Child, Preschool; D003609:Dactinomycin / Q000627:therapeutic use; D005260:Female; D005910:Glioma / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D005951:Glucose Tolerance Test; D019382:Human Growth Hormone / Q000378:metabolism* / Q000652:urine; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008279:Magnetic Resonance Imaging; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D019574:Optic Nerve Neoplasms / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D011388:Prolactin / Q000652:urine; D011629:Puberty, Precocious / Q000209:etiology; D014750:Vincristine / Q000627:therapeutic use; D015430:Weight Gain
D018972:Insulin-Like Growth Factor Binding Protein 3; D019382:Human Growth Hormone; D003609:Dactinomycin; D014750:Vincristine; D007334:Insulin-Like Growth Factor I; D011388:Prolactin