title: High-frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience.
abstract: OBJECTIVE
  The use of high-frequency oscillatory ventilation (HFOV) has increased dramatically in the management of respiratory failure in pediatric patients. We surveyed ten pediatric centers that frequently use high-frequency oscillation to describe current clinical practice and to examine factors related to improved outcomes.
  
  
  METHODS
  Retrospective, observational questionnaire study.
  
  
  METHODS
  Ten tertiary care pediatric intensive care units.
  
  
  METHODS
  Two hundred ninety patients managed with HFOV between January 1997 and June 1998.
  
  
  METHODS
  None.
  
  
  RESULTS
  Patients were classified according to presence or absence of preexisting lung disease, symptomatic respiratory syncytial virus infection, or presence of cyanotic heart disease or residual right-to-left intracardiac shunt. In addition, patients for whom HFOV acutely failed were analyzed separately. Those patients with preexisting lung disease were significantly smaller, had a significantly higher incidence of pulmonary infection as the triggering etiology, and had a significantly greater duration of conventional ventilation before institution of HFOV compared with patients without preexisting lung disease. Stepwise logistic regression was used to predict mortality and the occurrence of chronic lung disease in survivors. In patients without preexisting lung disease, the model predicted a 70% probability of death when the oxygenation index (OI) after 24 hrs was 28 in the immunocompromised patients and 64 in the patients without immunocompromise. In the immunocompromised patients, the model predicted a 90% probability of death when the OI after 24 hrs was 58. In survivors without preexisting lung disease, the model predicted a 70% probability of developing chronic lung disease when the OI at 24 hrs was 31 in the patients with sepsis syndrome and 50 in the patients without sepsis syndrome. In the patients with sepsis syndrome, the model predicted a 90% probability of developing chronic lung disease when the OI at 24 hrs was 45.
  
  
  CONCLUSIONS
  Given the number of centers involved and the size of the database, we feel that our results broadly reflect current practice in the use of HFOV in pediatric patients. These results may help in deciding which patients are most likely to benefit from aggressive intervention by using extracorporeal techniques and may help identify high-risk populations appropriate for prospective study of innovative modes of supporting gas exchange (e.g., partial liquid breathing or intratracheal pulmonary ventilation).
authors.affiliation: Department of Anesthesia, Children's Hospital, Boston, MA 02115, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Arnold
authors.forename: N G
authors.initials: NG
authors.lastname: Anas
authors.forename: P
authors.initials: P
authors.lastname: Luckett
authors.forename: I M
authors.initials: IM
authors.lastname: Cheifetz
authors.forename: G
authors.initials: G
authors.lastname: Reyes
authors.forename: C J
authors.initials: CJ
authors.lastname: Newth
authors.forename: K C
authors.initials: KC
authors.lastname: Kocis
authors.forename: S M
authors.initials: SM
authors.lastname: Heidemann
authors.forename: J H
authors.initials: JH
authors.lastname: Hanson
authors.forename: T V
authors.initials: TV
authors.lastname: Brogan
authors.forename: D J
authors.initials: DJ
authors.lastname: Bohn
mesh_terms: D001784:Blood Gas Analysis; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000379:methods; D005260:Female; D006612:High-Frequency Ventilation / Q000379:methods*; D006801:Humans; D016867:Immunocompromised Host; D015278:Intensive Care Units, Pediatric; D016015:Logistic Models; D008173:Lung Diseases, Obstructive / Q000209:etiology; D008297:Male; D018579:Patient Selection; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000145:classification / Q000209:etiology / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome