Stress management - heat shock protein-70 and the regulation of apoptosis.
Apoptosis, molecularly regulated cell death, can be induced by a range of environmental, physical or chemical stresses, and is characterized by a sequence of precisely regulated events that culminate in the self-destruction of a cell. Fascinating biochemical and genetic parallels exist between the cell death pathways of different animal species. However, an even more highly conserved and evolutionarily ancient cellular response can be engaged as a consequence of stress, which functions to maintain cellular survival. This response is mediated by the heat-shock or stress proteins. This article discusses the functional interactions between the stress response and the apoptotic cell death pathway and how these might impact on determining cellular survival.
Beere
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HM
La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, 92121, San Diego, CA, USA.
Green
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DR
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology*; D006801:Humans
D018840:HSP70 Heat-Shock Proteins