Effect of vilon on biological age and lifespan in mice.
Subcutaneous administration of vilon (Lys-Glu) to female CBA mice starting from the 6th month of life increased physical activity and endurance, decreased body temperature, prolonged the lifespan, and prevented the development of spontaneous neoplasms. Vilon had no effect on age-related changes of estrous function and free radical processes. Long-term administration of vilon caused no unfavourable effects on animal development. The obtained results show safety of chronic vilon administration and allow to use this preparation for geroprotection and prophylaxis of age pathology.
Khavinson
V K
VK
Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Science, St Petersburg. vvm@med-port.ru
Anisimov
V N
VN
Zavarzina
N Y
NY
Zabezhinskii
M A
MA
Zimina
O A
OA
Popovich
I G
IG
Shtylik
A V
AV
Malinin
V V
VV
Morozov
V G
VG
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004151:Dipeptides / Q000494:pharmacology*; D005260:Female; D008017:Life Expectancy; D051379:Mice; D008808:Mice, Inbred CBA; D009043:Motor Activity / Q000187:drug effects; D009374:Neoplasms, Experimental / Q000473:pathology; D012098:Reproduction / Q000187:drug effects
D004151:Dipeptides; C415909:lysylglutamic acid