Intra-muscular vidarabine therapy for polyomavirus-associated hemorrhagic cystitis following allogeneic hemopoietic stem cell transplantation.
Hemorrhagic cystitis (HC) is a common complication following hemopoietic stem cell transplantation (HSCT), its incidence ranging from 7 to 52% of all patients. Late occurring HC frequently results from viral infections. We describe a patient who developed severe polyomavirus-associated HC, which responded dramatically to a single dose of intra-muscular vidarabine. Previous studies show an improvement in HC with vidarabine therapy, but to date only the intravenous route of administration has been described and responses described take from several days to weeks. This report confirms the safety and efficacy of vidarabine administered intramuscularly when used in patients with an adequate platelet count, thereby making its use feasible when intravenous vidarabine is not available.
Seabra
C
C
Hematology Department, Centro Hospitalar de Coimbra, Portugal.
Pérez-Simón
J A
JA
Sierra
M
M
Marcos
J M
JM
Caballero
M D
MD
de la Loma
A
A
Vazquez
L
L
Del Cañizo
M C
MC
San Miguel
J F
JF
D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage*; D001739:BK Virus; D003556:Cystitis / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006470:Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D027601:Polyomavirus Infections / Q000188:drug therapy* / Q000209:etiology / Q000821:virology; D014740:Vidarabine / Q000008:administration & dosage*
D000998:Antiviral Agents; D014740:Vidarabine