The kallikrein-kininogen-kinin system: lessons from the quantification of endogenous kinins.
The purpose of the present review is to describe the place of endogenous kinins, mainly bradykinin (BK) and des-Arg(9)-BK in the kallikrein-kininogen-kinin system, to review and compare the different analytical methods reported for the assessment of endogenous kinins, to explain the difficulties and the pitfalls for their quantifications in biologic samples and finally to see how the results obtained by these methods could complement and extend the pharmacological evidence of their pathophysiological role.
Blais
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Faculté de pharmacie, Université de Montréal, 2900, Boul. Edouard-Montpetit, C.P. 6128, Succursale Centreville, Montréal, Québec H3C 3J7, Canada.
Marceau
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F
Rouleau
J L
JL
Adam
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A
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D006801:Humans; D007610:Kallikreins / Q000737:chemistry / Q000502:physiology*; D007700:Kinetics; D007704:Kininogens / Q000737:chemistry / Q000502:physiology*; D007705:Kinins / Q000737:chemistry / Q000502:physiology*; D008954:Models, Biological; D013997:Time Factors; D014018:Tissue Distribution
D000959:Antihypertensive Agents; D007704:Kininogens; D007705:Kinins; D007610:Kallikreins