title: Mechanisms of macrolide resistance in clinical pneumococcal isolates in France.
abstract: The genetic basis of macrolide resistance was investigated in a collection of 48 genotypically unrelated clinical isolates of Streptococcus pneumoniae obtained between 1987 and 1997 in France. All strains were resistant to erythromycin, clindamycin, and streptogramin B, exhibiting a macrolide-lincosamide-streptogramin B resistance phenotype, and harbored the erm(B) gene. None of the strains carried the mef(A) or erm(A) subclass erm(TR) gene.
authors.affiliation: Service de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Fitoussi
authors.forename: C
authors.initials: C
authors.lastname: Doit
authors.forename: P
authors.initials: P
authors.lastname: Geslin
authors.forename: N
authors.initials: N
authors.lastname: Brahimi
authors.forename: E
authors.initials: E
authors.lastname: Bingen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005602:France; D006801:Humans; D018942:Macrolides; D008780:Methyltransferases / Q000235:genetics; D010400:Penicillin G / Q000494:pharmacology; D010641:Phenotype; D011008:Pneumococcal Infections / Q000382:microbiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; D010400:Penicillin G