title: The high frequency of coeliac disease among children with neurological disorders.
abstract: In the present study we have explored antigliadin (AGA) and antireticulin (ARA) antibody tests for the serological screening for coeliac disease (CD) of 206 children with neurological disorders. IgA- or/and IgG-type AGA was discovered in 17 (8.3%) patients and IgA-type ARA in one (0.5%) patient. A small intestinal biopsy was performed in all 18 antibody-positive patients, and villous atrophy compatible with CD was revealed in three cases (patients with either epilepsy, retardation of psychomotor development or Down's syndrome). The CD prevalence rate of 14.6 per 1000 (95% CI 7.0-22.2) found in the present study was higher than could have been anticipated on the basis of the results of our previous population studies, which indicate that CD occurs more frequently among children with neurological disorders (OR = 37.6; 95% CI 9.7-146.9). Whether this finding reflects certain immunopathogenic links between CD and particular neurological diseases needs to be studied further. In this study, we were unable, using indirect immunofluorescence testing, to demonstrate the presence of autoantibodies against brain tissue in CD and AGA-positive patients.
authors.affiliation: Department of Immunology, University of Tartu, Tartu, Estonia.
authors.forename: L
authors.initials: L
authors.lastname: Salur
authors.forename: O
authors.initials: O
authors.lastname: Uibo
authors.forename: I
authors.initials: I
authors.lastname: Talvik
authors.forename: I
authors.initials: I
authors.lastname: Justus
authors.forename: K
authors.initials: K
authors.lastname: Metsküla
authors.forename: T
authors.initials: T
authors.lastname: Talvik
authors.forename: R
authors.initials: R
authors.lastname: Uibo
mesh_terms: D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D008403:Mass Screening; D009422:Nervous System Diseases / Q000150:complications*; D012155:Reticulin / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D012155:Reticulin; D005903:Gliadin