title: Relationship between abdominal fat compartments and glucose and lipid metabolism in early postmenopausal women.
abstract: The relationships between abdominal and pelvic fat compartments and glucose and lipid metabolism were investigated in early postmenopausal women. Fifty-five healthy, postmenopausal women aged 52-53 yr participated in the study. Fat distribution (intra-abdominal and sc abdominal fat, and intrapelvic and sc pelvic fat) was estimated by computed tomography. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. In a multiple regression analysis, the size of the intra-abdominal fat compartment was the only significant predictor of insulin sensitivity (r(2) = 24%; P = 0.0002). Plasma triglycerides were closely related to the size of the intra-abdominal fat compartment (r(2) = 26%; P < 0.0001), whereas plasma free fatty acid concentrations only correlated to the size of the sc abdominal fat compartment (r(2) = 18.5%, P = 0.001). In early postmenopausal women the amount of the intra-abdominal fat strongly influences insulin sensitivity and plasma triglyceride levels, whereas plasma free fatty acids are closely related to the amount of the sc abdominal fat. Accordingly, from a metabolic standpoint it seems most essential to reduce intra-abdominal fat in postmenopausal women.
authors.affiliation: Department of Vascular Diseases, Lund University, Malmö University Hospital, S20502 Malmö, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Rendell
authors.forename: U L
authors.initials: UL
authors.lastname: Hulthén
authors.forename: C
authors.initials: C
authors.lastname: Törnquist
authors.forename: L
authors.initials: L
authors.lastname: Groop
authors.forename: I
authors.initials: I
authors.lastname: Mattiasson
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005080:Exercise Test; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism; D007328:Insulin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology; D000078790:Insulin Secretion; D020738:Leptin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D012016:Reference Values; D012044:Regression Analysis; D012867:Skin; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D020738:Leptin; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol