Intraventricular injection of tachykinin NK3 receptor agonists suppresses the ingestion of NaCl-associated tastes.
The present experiments evaluated whether a salty taste was required for injections of a neurokinin-3 (NK3) receptor agonist (senktide) to suppress intake or whether senktide would reduce the intake of tastes that are predictive of NaCl. During training, different groups of rats were given access to 1% almond + water, 1% almond + 0.3 M NaCl, or 1% almond + 0.1 M sucrose. On the test day, rats were administered intraventricular injections of either saline or 200 ng senktide and then given access to 1% almond + water. Senktide had no effect on the intake of the water-associated or sucrose-associated almond. In contrast, senktide significantly reduced the intake of NaCl-associated almond. Senktide had no effect on almond intake by water-deprived rats. These results show that activation of NK3 receptors reduces the intake of NaCl and of a neutral taste that is predictive of sodium but not of calories.
Flynn
F W
FW
Department of Psychology, University of Wyoming, Laramie 82071, USA. flynn@uwyo.edu
D000818:Animals; D001245:Association Learning / Q000502:physiology; D001921:Brain / Q000502:physiology; D004326:Drinking / Q000502:physiology*; D008297:Male; D051381:Rats; D018042:Receptors, Neurokinin-3 / Q000502:physiology*; D012965:Sodium Chloride; D013395:Sucrose; D013649:Taste / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology*
D018042:Receptors, Neurokinin-3; D012965:Sodium Chloride; D013395:Sucrose