A SADS defect in tumor cells provides optimism.
SADS, a new component of the Fas-mediated apoptotic pathway, is downregulated in patients with colon carcinoma. Could this downregulation be a widespread mechanism of tumor cell immune invasion?
Takahashi
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Institute of Clinical Medicine and Research, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo, 105-8461, Japan. takahashi@jikei.ac.jp
D017209:Apoptosis / Q000502:physiology; D003110:Colonic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015536:Down-Regulation; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology*; D019014:fas Receptor / Q000502:physiology
D009363:Neoplasm Proteins; D019014:fas Receptor