title: A comparative study of surgical and medical procedures: 932 pregnancy terminations up to 63 days gestation.
abstract: The aim of this retrospective study was to compare the efficacy and complications associated with early medical and surgical pregnancy termination. The study population comprised 932 consecutive women undergoing pregnancy termination at gestations of 63 days or less. There were no age or parity differences between the study groups. Medical termination was performed with mifepristone 200 mg orally and misoprostol 800 microgram vaginally; surgical aspiration termination was performed under general anaesthesia. Outcome measures were: surgical curettage for presumed retained products of conception; ongoing pregnancy; and planned and emergency review in the unit. Early medical and surgical termination were associated with a 90.2 and 94.5% complete abortion rate respectively (P = 0.025). The complete abortion rate with medical termination decreased significantly with increasing parity; no such relationship with surgical abortion was found. Women of parity three or more were less likely to have a complete abortion following a medical (83.3%) compared to surgical procedure (97.7%) (P = 0.028). The ongoing pregnancy rate was 0.9% with medical and 0.5% with surgical termination (P = NS). Medical termination was associated with a lower complete abortion rate than surgical termination, particularly for women of higher parity. However, early medical termination allows over 90% of women to avoid the risks of surgical instrumentation of the uterus and anaesthesia.
authors.affiliation: Department of Obstetrics and Gynaecology, Women's Centre, The John Radcliffe Hospital, Headington, Oxford, UK. Tim.child@muhc.mcgill.ca
authors.forename: T J
authors.initials: TJ
authors.lastname: Child
authors.forename: J
authors.initials: J
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Rees
authors.forename: I Z
authors.initials: IZ
authors.lastname: MacKenzie
mesh_terms: D000019:Abortifacient Agents / Q000008:administration & dosage / Q000009:adverse effects; D000027:Abortion, Incomplete / Q000209:etiology; D000029:Abortion, Legal / Q000009:adverse effects / Q000379:methods*; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D015735:Mifepristone / Q000008:administration & dosage / Q000009:adverse effects; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects; D010298:Parity; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D000019:Abortifacient Agents; D016595:Misoprostol; D015735:Mifepristone