title: Reversal of left ventricular remodeling by synchronous biventricular pacing in heart failure.
abstract: Synchronous biventricular pacing is a new nonpharmacological supplemental treatment of advanced heart failure associated with electromechanical conduction delay. However, the role of pacing on left ventricular remodeling is unknown. Eleven patients with New York Heart Association Class III to IV heart failure, a left ventricular ejection fraction < 35%, and a QRS duration > or = 140 ms received a biventricular dual chamber pacemaker. Serial echocardiography, 6-minute hall walk, and Minnesota Living with Heart Failure quality-of-life (QOL) questionnaire were performed before and after up to 3 months of pacing. At 3 months there was a significant increase in fractional shortening (P < 0.001), ejection fraction (P < 0.001), and cardiac output (P < 0.05). The left ventricular end-diastolic volume (245 +/- 70 vs 185 +/- 37 mL, P < 0.05), end-systolic volume (209 +/- 69 vs 140 +/- 44 mL P < 0.05), and mitral regurgitation were reduced (P < 0.05), and diastolic filling time was lengthened (P < 0.05). There were also improvements in heart failure symptoms, an increase in 6-minute walk distance, and a decrease in QOL scores. Synchronous biventricular pacing for 3 months was associated with hemodynamic improvements, reversal of left ventricular remodeling, and increase in left ventricular systolic function, and a decrease in secondary mitral regurgitation.
authors.affiliation: Division of Cardiology, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. cplau@hkucc.hku.hk
authors.forename: C P
authors.initials: CP
authors.lastname: Lau
authors.forename: C M
authors.initials: CM
authors.lastname: Yu
authors.forename: E
authors.initials: E
authors.lastname: Chau
authors.forename: K
authors.initials: K
authors.lastname: Fan
authors.forename: H F
authors.initials: HF
authors.lastname: Tse
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: M O
authors.initials: MO
authors.lastname: Tang
authors.forename: S H
authors.initials: SH
authors.lastname: Wan
authors.forename: T C
authors.initials: TC
authors.lastname: Law
authors.forename: P Y
authors.initials: PY
authors.lastname: Lee
authors.forename: Y M
authors.initials: YM
authors.lastname: Lam
authors.forename: M R
authors.initials: MR
authors.lastname: Hill
mesh_terms: D002304:Cardiac Pacing, Artificial / Q000379:methods*; D002306:Cardiac Volume; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000628:therapy; D010138:Pacemaker, Artificial; D011788:Quality of Life; D012074:Remission Induction; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000628:therapy*; D018497:Ventricular Dysfunction, Right / Q000150:complications / Q000628:therapy*; D020257:Ventricular Remodeling