title: Presentation of self and microbial lipids by CD1 molecules.
abstract: CD1 molecules present both self lipids and microbial lipids. Recent studies have elucidated novel antigenic structures that can be presented by CD1 for T cell stimulation, as well as new pathways for lipid-antigen presentation. Additionally, the development of lipid-CD1 tetramers now permits the tracking of CD1-reactive T cells during immune responses. Despite this, the roles of CD1-reactive T cells in both host defense and immune regulation remain to be unequivocally defined.
authors.affiliation: Department of Biology, University of California at San Diego, 92121, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Kronenberg
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology / Q000378:metabolism; D018949:Antigens, CD1 / Q000276:immunology* / Q000378:metabolism; D000946:Antigens, Fungal / Q000276:immunology / Q000378:metabolism; D000953:Antigens, Protozoan / Q000276:immunology / Q000378:metabolism; D001324:Autoantigens / Q000378:metabolism*; D002240:Carbohydrate Sequence; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000276:immunology*; D008969:Molecular Sequence Data
chemical_list: D000942:Antigens, Bacterial; D018949:Antigens, CD1; D000946:Antigens, Fungal; D000953:Antigens, Protozoan; D001324:Autoantigens; D008055:Lipids