One- and two-compartment minimal models detect similar alterations of glucose metabolism indexes in hypertension.
A standard intravenous glucose tolerance test (IVGTT) was performed in 10 nondiabetic patients with essential hypertension (H group) and 9 normotensive control subjects (N group). A 2-compartment minimal model (2CMM) of glucose kinetics was applied to estimate indexes of glucose effectiveness, S2G and insulin sensitivity, S2I, by means of a maximum a posteriori (MAP) bayesian estimation technique. These estimates were contrasted to the S1G and S1I indexes provided by the classic minimal model (1CMM). In both the N group and the H group, the 2CMM underestimated the glucose effectiveness and overestimated the insulin sensitivity. In the H group, S2G was, on average, 63% of S1G (P > .05) and S2I was 137% of S1I (P > .05). In the N group S2G was 67% of S1G (P > .05) and S2I was 134% of S1I (P > .05). The 2CMM detected a reduction of approximately 40% (P > .05) and approximately 48% (P > .05) in S2G and S2I estimates, respectively, from the N group to the H group. Despite its reduced complexity, the 1CMM also detected a reduction of approximately 35% (P < .05) and approximately 49% (P < .05) in the S1G and in S1I indexes, respectively. Thus, the 1CMM and 2CMM showed a substantial equivalence in detecting a severe reduction in insulin sensitivity and impaired glucose effectiveness in hypertensive patients compared with normal.
Natalucci
S
S
Department of Electronics and Automatics, University of Ancona, Italy.
Boemi
M
M
Fumelli
P
P
Testa
I
I
Fumelli
D
D
Burattini
R
R
D000328:Adult; D005260:Female; D005947:Glucose / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000502:physiology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D012016:Reference Values
D005947:Glucose