title: A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
abstract: Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-beta or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.
authors.affiliation: Pathology Department, Rambam Medical Center, Haifa, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Larisch
authors.forename: Y
authors.initials: Y
authors.lastname: Yi
authors.forename: R
authors.initials: R
authors.lastname: Lotan
authors.forename: H
authors.initials: H
authors.lastname: Kerner
authors.forename: S
authors.initials: S
authors.lastname: Eimerl
authors.forename: W
authors.initials: W
authors.lastname: Tony Parks
authors.forename: Y
authors.initials: Y
authors.lastname: Gottfried
authors.forename: S
authors.initials: S
authors.lastname: Birkey Reffey
authors.forename: M P
authors.initials: MP
authors.lastname: de Caestecker
authors.forename: D
authors.initials: D
authors.lastname: Danielpour
authors.forename: N
authors.initials: N
authors.lastname: Book-Melamed
authors.forename: R
authors.initials: R
authors.lastname: Timberg
authors.forename: C S
authors.initials: CS
authors.lastname: Duckett
authors.forename: R J
authors.initials: RJ
authors.lastname: Lechleider
authors.forename: H
authors.initials: H
authors.lastname: Steller
authors.forename: J
authors.initials: J
authors.lastname: Orly
authors.forename: S J
authors.initials: SJ
authors.lastname: Kim
authors.forename: A B
authors.initials: AB
authors.lastname: Roberts
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001483:Base Sequence; D019556:COS Cells; D020169:Caspases / Q000378:metabolism; D003001:Cloning, Molecular; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017931:DNA Primers / Q000235:genetics; D004789:Enzyme Activation; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015870:Gene Expression; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008969:Molecular Sequence Data; D058112:Septins; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D014162:Transfection; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D003598:Cytoskeletal Proteins; D017931:DNA Primers; D016212:Transforming Growth Factor beta; D020169:Caspases; D020558:GTP Phosphohydrolases; C492027:SEPTIN4 protein, human; D058112:Septins