Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.
A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impaired T-lymphocyte transformation by PHA in uremic patients suffering from recurrent infectious diseases. The synthetic analogue was found to have stronger restorative activity than those of our synthetic TP II and [Phe (4F)3] TP II.
Abiko
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Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd, Iwate-ken, Japan. nakatubo@mx2.alpha-web.ne
Nakatsubo
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D000595:Amino Acid Sequence; D016022:Case-Control Studies; D006801:Humans; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008969:Molecular Sequence Data; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology*; D013946:Thymopoietins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014511:Uremia / Q000188:drug therapy* / Q000276:immunology*
D018836:Inflammation Mediators; D010835:Phytohemagglutinins; D013946:Thymopoietins; C422709:thymopoietin II, 4-fluoro-Phe(3)-; C422708:thymopoietin II, Nal(3)-