title: Giraffe strain of pestivirus: its taxonomic status based on the 5'-untranslated region.
abstract: The 5'-untranslated region (5'-UTR) of the 'Giraffe' strain of pestivirus was sequenced for comparison with those of other pestiviruses from cattle, sheep, goats, and swine. A phylogenetic tree constructed with these strains suggested that the 'Giraffe' strain was allocated to a new taxon. This observation was also confirmed by a newly proposed method based on palindromic nucleotide substitutions (PNS) at the three variable regions in the 5'-UTR. Other reported pestivirus strains isolated from deer were assigned as bovine viral disease virus (BVDV)-1 according to the PNS as well as phylogenetic analysis, suggesting that BVDV-1 strains can cross-infect deer as well as cattle, sheep, goats, and swine, and that wild deer may serve as a reservoir of BVDV-1. We also identified the genovar of a deer isolate, SH9/11, as BVDV-1c by the PNS method.
authors.affiliation: Animal Center for Biomedical Research, Faculty of Medicine, The University of Tokyo, Japan. ryo@m.u-tokyo.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Harasawa
authors.forename: M
authors.initials: M
authors.lastname: Giangaspero
authors.forename: G
authors.initials: G
authors.lastname: Ibata
authors.forename: D J
authors.initials: DJ
authors.lastname: Paton
mesh_terms: D020121:5' Untranslated Regions; D000818:Animals; D001188:Artiodactyla / Q000821:virology*; D020029:Base Pairing; D001483:Base Sequence; D003670:Deer / Q000821:virology; D016679:Genome, Viral; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010576:Pestivirus / Q000235:genetics*; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment
chemical_list: D020121:5' Untranslated Regions