Carotid baroreflex pressor responses at rest and during exercise: cardiac output vs. regional vasoconstriction.
The arterial baroreflex mediates changes in arterial pressure via reflex changes in cardiac output (CO) and regional vascular conductance, and the relative roles may change between rest and exercise and across workloads. Therefore, we quantified the contribution of CO and regional vascular conductances to carotid baroreflex-mediated increases in mean arterial pressure (MAP) at rest and during mild to heavy treadmill exercise (3.2 kph; 6.4 kph, 10% grade; and 8 kph, 15% grade). Dogs (n = 8) were chronically instrumented to measure changes in MAP, CO, hindlimb vascular conductance, and renal vascular conductance in response to bilateral carotid occlusion (BCO). At rest and at each workload, BCO caused similar increases in MAP (average 35 +/- 2 mmHg). In response to BCO, neither at rest nor at any workload were there significant increases in CO; therefore, the pressor response occurred via peripheral vasoconstriction. At rest, 10.7 +/- 1.4% of the rise in MAP was due to vasoconstriction in the hindlimb, whereas 4.0 +/- 0.7% was due to renal vasoconstriction. Linear regression analysis revealed that, with increasing workloads, relative contributions of the hindlimb increased and those of the kidney decreased. At the highest workload, the decrease in hindlimb vascular conductance contributed 24.3 +/- 3.4% to the pressor response, whereas the renal contribution decreased to only 1.6 +/- 0.3%. We conclude that the pressor response during BCO was mediated solely by peripheral vasoconstriction. As workload increases, a progressively larger fraction of the pressor response is mediated via vasoconstriction in active skeletal muscle and the contribution of vasoconstriction in inactive beds (e.g., renal) becomes progressively smaller.
Collins
H L
HL
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Augustyniak
R A
RA
Ansorge
E J
EJ
O'Leary
D S
DS
D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology*; D002339:Carotid Arteries / Q000502:physiology*; D002346:Carotid Sinus / Q000502:physiology; D004285:Dogs; D005260:Female; D007022:Hypotension / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology; D005082:Physical Exertion / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology*