title: Subcutaneous administration of nicotine changes dorsal raphe serotonergic neurons discharge rate during REM sleep.
abstract: In the present study nicotine (0.1 mg/kg, s.c.) increased discharge rate of putative dorsal raphe (DRN) serotonergic neurons of behaving rats during REM sleep (362.61%), without any significant change during waking and non-REM sleep. Since serotonergic DRN neurons gate PGO onset, these results suggest that nicotine-induced suppression of PGO spikes during REM sleep previously reported is achieved through stimulation of dorsal raphe serotonergic cells.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, AP 70-250, 04510, D.F., México, Mexico.
authors.forename: R
authors.initials: R
authors.lastname: Guzmán-Marín
authors.forename: M N
authors.initials: MN
authors.lastname: Alam
authors.forename: S
authors.initials: S
authors.lastname: Mihailescu
authors.forename: R
authors.initials: R
authors.lastname: Szymusiak
authors.forename: D
authors.initials: D
authors.lastname: McGinty
authors.forename: R
authors.initials: R
authors.lastname: Drucker-Colín
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography; D007279:Injections, Subcutaneous; D009474:Neurons / Q000145:classification / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009538:Nicotine / Q000008:administration & dosage*; D011903:Raphe Nuclei / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology; D014851:Wakefulness / Q000187:drug effects
chemical_list: D012701:Serotonin; D009538:Nicotine