title: Germinated and nongerminated conidial suspensions for testing of susceptibilities of Aspergillus spp. to amphotericin B, itraconazole, posaconazole, ravuconazole, and voriconazole.
abstract: The effect of germinated and nongerminated conidia of Aspergillus spp. on the fungistatic (National Committee for Clinical Laboratory Standards document M38-P) and fungicidal activities (MICs and minimal fungicidal concentrations [MFCs] respectively) of amphotericin B, itraconazole, posaconazole (SCH56592), ravuconazole (BMS-207147), and voriconazole was evaluated. MFCs were the lowest drug dilutions that showed fewer than three colonies (99.9% killing). Overall, the MICs (0.12 to 4 microg/ml) and MFCs (0.5 to >8 microg/ml) of all of the agents tested with both inocula were the same or within 2 dilutions for the 72 isolates. Therefore, MICs and MFCs can be obtained with convenient and standardized nongerminated conidia.
authors.affiliation: Medical College of Virginia/Virginia Commonwealth University, Richmond, Virginia 23298, USA. AVINGROFF@HSC.VCU.EDU
authors.forename: A
authors.initials: A
authors.lastname: Espinel-Ingroff
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000254:growth & development; D002175:Candida / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents