Myocardial gene transfer.
Recent improvements in both gene transfer vectors and in vivo gene delivery techniques have facilitated genetic manipulation of myocardial function and enabled targeted therapy of animal models of cardiac disease and, in particular, heart failure. Increases in myocardial perfusion, improved calcium handling, and enhanced beta-adrenergic receptor signaling have all been achieved by gene transfer in animal models, and appear to be important determinants of myocardial function. Increased understanding of the molecular etiologies of myocardial disease processes combined with advances in vectors and gene delivery will facilitate the development of novel therapies and represent important progress in the effort to make myocardial gene therapy a clinical reality beyond experimental protocols.
White
D C
DC
Department of Surgery, Box 2606, MSRB Room 471, Duke University Medical Center, Durham, NC 27710, USA.
Koch
W J
WJ
D000818:Animals; D002118:Calcium / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000627:therapeutic use; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006331:Heart Diseases / Q000628:therapy*; D006801:Humans; D008222:Lymphokines / Q000627:therapeutic use; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D014162:Transfection; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D002118:Calcium