title: De novo spinal teratoma after treatment of an intracranial germ cell tumor.
abstract: The authors report an extremely rare case of de novo spinal teratoma after treatment for intracranial germ cell tumor. A 17-year-old male developed pain of bilateral lower extremities and urinary retention 18 months after complete remission of intracranial mixed germ cell tumor. Magnetic resonance imaging revealed a huge spinal tumor associated with spina bifida occulta. Total resection was performed, and histogenetical findings led to the diagnosis of a mature teratoma with normal p16 gene, whereas analysis of intracranial tumor showed p16 deletion. The spinal anomaly and genetic analysis strongly suggest that the spinal teratoma was a de novo tumor rather than a metastasis or dissemination of the original intracranial germ cell tumor.
authors.affiliation: Department of Neurology, Kanazawa University School of Medicine, Kanazawa, Japan. tohma@ns.m.kanazawa-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Tohma
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: D
authors.initials: D
authors.lastname: Kita
authors.forename: M
authors.initials: M
authors.lastname: Iwato
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: O
authors.initials: O
authors.lastname: Tachibana
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: J
authors.initials: J
authors.lastname: Yamashita
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D002872:Chromosome Deletion; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D003131:Combined Modality Therapy; D018237:Germinoma / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D010870:Pineal Gland / Q000000981:diagnostic imaging* / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000175:diagnosis*; D013724:Teratoma / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed