[The frequency of peri- and postoperative bleeding after prophylactic treatment with enoxapirin in patients with post-traumatic deep vein thrombosis].
The risk of moderate and major hemorrhage was assessed in patients who underwent surgery after trauma of the lower limb. Among 633 patients over 40 years of age, to whom enoxapirin was administered, signs of major bleeding (massive bleeding during surgery, a decrease of Hb concentration by at least 2 g%, a transfusion consisting of 2 or more units of blood, a loss of more than 200 ml of blood from the surgical wound in the first 24 hours post surgery, formation of a haematoma in the surgical wound requiring evacuation) was noted in 10 (1.6%) cases. In 48 (7.6%) cases signs of moderate bleeding were noted (a decrease of Hb concentration of less than 2 g%, either not requiring blood transfusion or a transfusion of no more than 1 unit of blood, a drainage of not more than 200 ml of blood from the surgical wound in the first 24 hours post surgery). The noted hemorrhages didn't lead to any life threatening conditions, nor to any deaths. No cases of pulmonary embolism were noted either. The presented cases seem to indicate that the risk of increased bleeding in trauma patients treated with enoxapirin is incomparably smaller than the risk of life threatening complications like pulmonary thromboses. The obtained results indicate the purposefulness of thrombosis prophylaxis in patients undergoing surgery because of mechanical trauma of the lower limbs.
Szczesny
G
G
Oddział Ortopedyczno-Urazowy, Szpital Czerniakowski w Warszawie.
Deszczyński
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D001803:Blood Transfusion; D017984:Enoxaparin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007869:Leg Injuries / Q000150:complications* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D018570:Risk Assessment; D013924:Thrombophlebitis / Q000209:etiology / Q000517:prevention & control*
D000925:Anticoagulants; D017984:Enoxaparin