title: NO vascular control in Duchenne muscular dystrophy.
abstract: A new investigation into Duchenne muscular dystrophy (DMD) pathogenesis suggests that at least part of the muscle degeneration observed in DMD patients may result from the reduced production of muscle membrane-associated neuronal nitric oxide synthase. This reduction may lead to impaired regulation of the vasoconstrictor response and eventual muscle damage.
authors.affiliation: Department of Physiological Science, University of California, Los Angeles, CA 90095, USA. rcrosbie@physci.ucla.edu
authors.forename: R H
authors.initials: RH
authors.lastname: Crosbie
mesh_terms: D006801:Humans; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis*; D052248:Nitric Oxide Synthase Type I; D014661:Vasoconstriction / Q000502:physiology*
chemical_list: D009569:Nitric Oxide; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I