[Encephalomyelitis disseminata: clinical aspects, pathogenesis and current therapy concepts].
Multiple sclerosis (MS) is considered as a T-cell mediated autoimmune disease. Caused by central nervous system demyelination and axonal damage varying clinical signs do occur either with relapsing-remitting or with chronic progressive course. Based on pathogenetic considerations immunomodulative and immunosuppressive therapeutical approaches are used to limit the disease progression. Clinical symptoms, diagnostic criteria, pathogenetical considerations, and consecutive therapeutical interventions are summarized.
Merkelbach
S
S
Neurologische Klinik, Universitätskliniken Homburg/Saar. merkelb1@hotmail.com
Kölmel
C
C
Schimrigk
K
K
D001324:Autoantigens / Q000276:immunology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
D001324:Autoantigens; D016207:Cytokines; D007166:Immunosuppressive Agents