title: Association between apolipoprotein E genotypes and cancer risk in patients with acquired immunodeficiency syndrome.
abstract: The apolipoprotein E (apoE) genotype was determined in 197 deceased acquired immunodeficiency syndrome (AIDS) patients treated at Ullevaal Hospital in Oslo, Norway. A full autopsy had been performed on all. Cancer had developed in 71 individuals, mainly lymphomas (46) and Kaposi's sarcomas (18). The apoE genotype distribution was consistent with Hardy-Weinberg equilibrium, and allele frequencies were in the typical Scandinavian range (6.9% apoE2; 75.6% apoE3; and 17.5% apoE4). Cancer cases had a significantly higher frequency of apoE4 alleles than noncancer cases (24.6% and 13.5%, respectively) and a lower frequency of apoE2 alleles (3.5% versus 8.7%). Background factors, such as survival from AIDS diagnosis, could not explain these differences. Our study thus indicates that apoE genotype affects the development of cancers among AIDS patients.
authors.affiliation: Department of Informatics, University of Oslo, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Liestøl
authors.forename: E A
authors.initials: EA
authors.lastname: Kvittingen
authors.forename: H
authors.initials: H
authors.lastname: Rootwelt
authors.forename: O
authors.initials: O
authors.lastname: Dunlop
authors.forename: A K
authors.initials: AK
authors.lastname: Goplen
authors.forename: J C
authors.initials: JC
authors.lastname: Pedersen
authors.forename: S H
authors.initials: SH
authors.lastname: Brorson
authors.forename: A L
authors.initials: AL
authors.lastname: Børresen-Dale
authors.forename: B
authors.initials: B
authors.lastname: Myrvang
authors.forename: J
authors.initials: J
authors.lastname: Maehlen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000235:genetics*; D008297:Male; D012514:Sarcoma, Kaposi / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E