title: Pyrrolidine PNA: a novel conformationally restricted PNA analogue.
abstract: [reaction:see text] A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA adenine decamer.
authors.affiliation: Center for Biomolecular Recognition, Department for Biochemistry and Genetics, Biochemistry Laboratory B, The Panum Institute, Blegdamsvej 3C, DK-2200, Copenhagen, Denmark. ask@kiku.dk
authors.forename: A
authors.initials: A
authors.lastname: Püschl
authors.forename: T
authors.initials: T
authors.lastname: Tedeschi
authors.forename: P E
authors.initials: PE
authors.lastname: Nielsen
mesh_terms: D004247:DNA / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D020135:Peptide Nucleic Acids; D011759:Pyrrolidines; D004247:DNA