title: Circadian regulation of the light input pathway in Neurospora crassa.
abstract: FREQUENCY (FRQ) is a critical element of the circadian system of Neurospora. The white collar genes are important both for light reception and circadian function. We show that the responsiveness of the light input pathway is circadianly regulated. This circadian modulation extends to light-inducible components and functions that are not rhythmic themselves in constant conditions. FRQ interacts genetically and physically with WHITE COLLAR-1, and physically with WHITE COLLAR-2. These findings begin to address how components of the circadian system interact with basic cellular functions, in this case with sensory transduction.
authors.affiliation: Institute for Medical Psychology, University of Munich, D-80336 Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Merrow
authors.forename: L
authors.initials: L
authors.lastname: Franchi
authors.forename: Z
authors.initials: Z
authors.lastname: Dragovic
authors.forename: M
authors.initials: M
authors.lastname: Görl
authors.forename: J
authors.initials: J
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Brunner
authors.forename: G
authors.initials: G
authors.lastname: Macino
authors.forename: T
authors.initials: T
authors.lastname: Roenneberg
mesh_terms: D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology; D005800:Genes, Fungal; D008027:Light; D009154:Mutation; D009492:Neurospora crassa / Q000235:genetics / Q000502:physiology* / Q000528:radiation effects*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; C087405:FRQ protein, Neurospora crassa; D005656:Fungal Proteins; D014157:Transcription Factors; C105589:wc-1 protein, Neurospora crassa; C103772:white collar 2 protein, Neurospora