Paxillin and focal adhesion signalling.
To facilitate a rapid response to environmental change, cells use scaffolding - or adaptor - proteins to recruit key components of their signal-transduction machinery to specific subcellular locations. Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals.
Turner
C E
CE
Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA. turnerc@mail.upstate.edu
D020727:ADP-Ribosylation Factors / Q000502:physiology; D000199:Actins / Q000502:physiology; D020816:Amino Acid Motifs; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D008954:Models, Biological; D051419:Paxillin; D010750:Phosphoproteins / Q000737:chemistry / Q000502:physiology*; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000502:physiology
D000199:Actins; D003598:Cytoskeletal Proteins; D006133:Growth Substances; D016023:Integrins; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins; D020727:ADP-Ribosylation Factors; D020741:rho GTP-Binding Proteins