Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety.
1Alpha,25-dihydroxyvitamin D3 diastereomer, differing from the parent compound in configuration at four asymmetric carbon atoms in the rings C/D and side chain (C13, C14, C17 and C20), was synthesized and shown to have a significant affinity for the vitamin D receptor.
Marczak
S
S
Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw.
Przezdziecka
A
A
Wicha
J
J
Steinmeyer
A
A
Zügel
U
U
D002117:Calcitriol / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D008968:Molecular Conformation; D015394:Molecular Structure; D011485:Protein Binding; D018167:Receptors, Calcitriol / Q000378:metabolism*; D013237:Stereoisomerism
D018167:Receptors, Calcitriol; D002117:Calcitriol