title: Effects of microinjection of OFQ into PAG on spinal dorsal horn WDR neurons in rats.
abstract: The aim of the present study was to examine the effect of microinjection of orphanin FQ (OFQ) into periaqueductal gray (PAG) on sensory processing in the wide dynamic range (WDR) neurons of the spinal dorsal horn and to explore the effect of OFQ on a descending system of pain modulation. The results show that microinjection of OFQ into ipsilateral PAG significantly facilitated C-fibre evoked response and post-discharge of spinal dorsal horn WDR neurons. This is consistent with our previous results obtained in behavioral studies. It suggests that the supraspinal effect of OFQ on pain may partly be mediated by PAG neurons.
authors.affiliation: State Key Laboratory of Medical Neurobiology, Department of Neurobiology, Shanghai Medical University, 138 Yi Xue Yuan Road, 200032, Shanghai, PR China.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Yang
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Zhang
authors.forename: G C
authors.initials: GC
authors.lastname: Wu
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D008845:Microinjections; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D018847:Opioid Peptides / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology; D010487:Periaqueductal Gray / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D020671:Posterior Horn Cells / Q000166:cytology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014665:Vasodilator Agents / Q000494:pharmacology*; D000097629:Nociceptin
chemical_list: D018847:Opioid Peptides; D014665:Vasodilator Agents; D000097629:Nociceptin