title: Rapidly destructive arthropathy of the hip in haemophilia.
abstract: The aetiology of rapidly destructive arthropathy is still being debated. We report a 48-year-old male haemophiliac who exhibited hip arthropathy that was similar to rapidly destructive arthropathy. The hip joint was destroyed 6 months after the onset of symptoms. Results of clinical and laboratory examinations did not show any features of neuropathic, inflammatory or septic arthropathy, except for coagulopathy. Magnetic resonance imaging revealed an expansive joint capsule with synovial proliferation in the affected hip joint. Total hip arthroplasty was carried out successfully with total resection of the synovial tissue and joint capsule. A histological examination revealed bone necrosis, nonspecific inflammation, haemosiderosis and synovial hypertrophy. The recurrent bleeding into the hip joint induced pronounced inflammation with synovial proliferation and acute destruction of bony tissue.
authors.affiliation: Department of Orthopedic Surgery, Department of Blood Transfusion Service, Nagoya University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ishiguro
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Oguchi
authors.forename: J
authors.initials: J
authors.lastname: Takamatsu
authors.forename: H
authors.initials: H
authors.lastname: Iwata
mesh_terms: D006467:Hemophilia A / Q000150:complications / Q000473:pathology*; D006615:Hip / Q000473:pathology*; D006801:Humans; D007592:Joint Diseases / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged