title: Chromatographic study of terpene derivatives on porous graphitic carbon stationary phase with beta-cyclodextrin as mobile phase modifier.
abstract: The stoichiometric coefficients and apparent formation constants (Kf) of alpha-terpineol, thymol, geraniol and linalool complexes with beta-cyclodextrin (beta-CD) were determined using HPLC with a porous graphitic carbon (PGC) chromatographic support. Measurements were performed with four different methanol-water mobile phases. All the terpene derivatives under study form 1:1 guest-CD complexes. Graphs of Kf as a function of the mobile phase composition appeared different from those classically described for RP-C18 and suggest that the PGC stationary phase could play an active role in the complexation process. Solute-CD inclusion and solute-stationary phase interactions may be involved in this specific behavior.
authors.affiliation: Laboratoire de Chimie Analytique et de Bromatologie, Université de Limoges, Faculté de Pharmacie, France.
authors.forename: I
authors.initials: I
authors.lastname: Clarot
authors.forename: D
authors.initials: D
authors.lastname: Clédat
authors.forename: S
authors.initials: S
authors.lastname: Battu
authors.forename: P J
authors.initials: PJ
authors.lastname: Cardot
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry; D013729:Terpenes / Q000737:chemistry*; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D013729:Terpenes; D047392:beta-Cyclodextrins; D006108:Graphite; C031215:betadex