title: New strong fibrates with piperidine moiety.
abstract: New fibrates containing piperidine, 4-hydroxypiperidine, piperidin-3-ene, and piperazine moieties in the structures were synthesized and evaluated. Among the synthesized compounds, 2-[3-[1-(4-fluorobenzoyl)-piperidin-4yl]phenoxyl-2-methylpropanoic acid (9aA: AHL-157) showed very superior activities in decreasing triglyceride, cholesterol, and blood sugar compared to bezafibrate in mice and rats.
authors.affiliation: Central Research Labs, SSP Co, Ltd, Narita, Chiba, Japan. Teruo.Komoto@ssp.co.jp
authors.forename: T
authors.initials: T
authors.lastname: Komoto
authors.forename: T K
authors.initials: TK
authors.lastname: Hirota
authors.forename: M
authors.initials: M
authors.lastname: Otsuka
authors.forename: J
authors.initials: J
authors.lastname: Kotake
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Koya
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006937:Hypercholesterolemia / Q000188:drug therapy; D015228:Hypertriglyceridemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry*; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D010879:Piperazines; D010880:Piperidines; D011422:Propionates; D000077489:Piperazine; C032727:piperidine