title: Hepatitis B and C virus markers among patients with hepatosplenic mansonic schistosomiasis.
abstract: OBJECTIVE
  To evaluate the frequency and the consequences of the co-infection of hepatitis B and C viruses in patients with hepatosplenic schistosomiasis (HSS).
  
  
  METHODS
  B and C serologic markers, exposure to risk factors, biochemical assays, upper gastrointestinal endoscopies, and abdominal ultrasonograms were evaluated in 101 patients with HSS from 1994 to 1997. Whenever possible, PCR was tested and histopathological studies were reviewed.
  
  
  RESULTS
  At least one HBV virus marker was found in 15.8%, and anti-HCV was detected in 12.9% of the subjects. The seropositive subjects tended to be older than the seronegative ones. A history of blood transfusion was significantly related to the presence of anti-HCV. Three (18.75%) out of 16 subjects exposed to B virus were HBsAg positive. Eleven (84.6%) out of thirteen patients who were anti-HCV positive demonstrated viral activity. Patients with ongoing viral infection presented a higher average level of liver aminotransferases, a higher frequency of cell decompensation and a higher rate of chronic hepatitis. Portal hypertension parameters were not influenced by viral exposure.
  
  
  CONCLUSIONS
  The rate of hepatitis B and C viruses serologic markers observed in the patients with HSS was higher than the control group. The co-infection was responsible for a higher frequency of cell decompensation.
authors.affiliation: Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, 01277-900, Brasil.
authors.forename: R T
authors.initials: RT
authors.lastname: Aquino
authors.forename: P P
authors.initials: PP
authors.lastname: Chieffi
authors.forename: S M
authors.initials: SM
authors.lastname: Catunda
authors.forename: M F
authors.initials: MF
authors.lastname: Araújo
authors.forename: M C
authors.initials: MC
authors.lastname: Ribeiro
authors.forename: E F
authors.initials: EF
authors.lastname: Taddeo
authors.forename: E G
authors.initials: EG
authors.lastname: Rolim
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood*; D006526:Hepatitis C / Q000150:complications / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012555:Schistosomiasis mansoni / Q000150:complications / Q000276:immunology*; D013158:Splenic Diseases / Q000150:complications / Q000276:immunology* / Q000469:parasitology; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies