CD1d-restricted mouse V alpha 14 and human V alpha 24 T cells: lymphocytes of innate immunity.
Mouse V alpha 14 T cells and their human homologs, V alpha 24 T cells, are prominent subsets of CD1d-restricted T cells. Here we discuss their striking similarities to B-1 B cells and gammadelta T cells and propose that these immune cells mediate various innate strategies in response to endogenous or exogenous danger signals.
Benlagha
K
K
Schultz Laboratory, Department of Molecular Biology, Princeton University, Princeton NJ 08544, USA.
Bendelac
A
A
D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism*
D018949:Antigens, CD1; D016693:Receptors, Antigen, T-Cell, alpha-beta