Decreased tolerance to acoustic stress in late postresuscitation period in Krushinsky-Molodkina rats.
The effect of circulation arrest on the development of stress-induced injuries was studied in Krushinsky-Molodkina rats genetically predisposed to audiogenic seizure. Resuscitated rats were subjected to acoustic stress 1.5 month after circulation arrest. The severity of neurological disorders and the frequency and severity of intracranial hemorrhages increased, while excitability of the central nervous system remained unchanged during stress. Thus, the resistance to stress considerably decreased in rats survived a short-term circulatory arrest due to dysfunction of the autonomic nervous regulation of hemodynamics rather than enhanced excitability of the central nervous system.
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Department of Human and Animal Physiology, Faculty of Biology, MV Lomonosov Moscow State University. ovin@telemed.ru
Volkov
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Koshelev
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D000161:Acoustic Stimulation; D000222:Adaptation, Physiological; D000818:Animals; D001775:Blood Circulation; D002490:Central Nervous System / Q000503:physiopathology; D020195:Epilepsy, Reflex / Q000235:genetics* / Q000503:physiopathology; D051381:Rats; D012151:Resuscitation