title: Transmission of tuberculosis in the prison of Antananarivo (Madagascar).
abstract: The prevalence of tuberculosis in the Antananarivo prison is 16 times higher than that in the general population of Madagascar. We compared the clustering of Mycobacterium tuberculosis strains within and outside the prison and studied the transmission of strains in the prison. M. tuberculosis strains isolated in 1994 to 1995 from 146 prisoners and from 260 nonprisoner patients from Antananarivo were typed using the genetic markers IS6110 and direct repeat. We compared the strains isolated from prisoners and nonprisoners and found that the clustering rate was higher within (58.9%) than outside the prison (40%) suggesting that the transmission rate was higher in prison. Of the 146 incarcerated patients, 82 were grouped into 22 clusters. We checked for possible tuberculosis transmission between prisoners with identical strains by epidemiological investigation of the various prison clusters. We found that 9.5% of the incarcerated patients could have been sources of infection and that only 15.1% could have been infected in the prison. One hundred and twenty-seven prison patients were new cases. Epidemiological data suggested that 37% of them resulted from a reactivation of an old infection, due to poor living conditions or recent transmission from an index case outside the prison.
authors.affiliation: Unité tuberculose, Institut Pasteur, Antananarivo, Madagascar. vrasolof@pasteur.mg
authors.forename: V
authors.initials: V
authors.lastname: Rasolofo-Razanamparany
authors.forename: D
authors.initials: D
authors.lastname: Ménard
authors.forename: M
authors.initials: M
authors.lastname: Ratsitorahina
authors.forename: G
authors.initials: G
authors.lastname: Aurégan
authors.forename: B
authors.initials: B
authors.lastname: Gicquel
authors.forename: S
authors.initials: S
authors.lastname: Chanteau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004251:DNA Transposable Elements / Q000235:genetics; D005260:Female; D006801:Humans; D008270:Madagascar / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012150:Polymorphism, Restriction Fragment Length; D011329:Prisoners; D011330:Prisons; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission*
chemical_list: D004251:DNA Transposable Elements