The interaction between anticoagulant protein S and complement regulatory C4b-binding protein (C4BP).
An important mechanism of regulation of blood coagulation is the anticoagulant protein C pathway. In this pathway, the anticoagulant activity of activated protein C is increased by its cofactor protein S. The cofactor activity of protein S can be regulated by binding to complement regulatory C4b-binding protein (C4BP). The sites of interaction of protein S and C4BP are discussed.
van de Poel
R H
RH
Department of Haematology, University Medical Center Utrecht, the Netherlands.
Meijers
J C
JC
Bouma
B N
BN
D000818:Animals; D000925:Anticoagulants / Q000097:blood*; D001665:Binding Sites; D001777:Blood Coagulation / Q000502:physiology; D015935:Complement C4b / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D016167:Integrin alphaXbeta2 / Q000097:blood*; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000925:Anticoagulants; D016167:Integrin alphaXbeta2; D011486:Protein C; D017293:Protein S; D015935:Complement C4b