title: Effects of a glucose meal on energy metabolism in patients with cirrhosis before and after liver transplantation.
abstract: OBJECTIVE
  Liver transplantation results in hepatic denervation. This may produce alterations of liver energy and substrate metabolism, which may contribute to weight gain after liver transplantation.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  Liver transplantation clinics in a university hospital.
  
  
  METHODS
  Seven nondiabetic patients with cirrhosis were recruited while on a waiting list for liver transplantation. Seven healthy subjects were recruited as controls.
  
  
  METHODS
  Orthotopic liver transplantation.
  
  
  METHODS
  Evaluation of energy and substrate metabolism after ingestion of a glucose load with indirect calorimetry was performed before, 2 to 6 weeks after, and 5 to 19 months after transplantation. Whole-body glucose oxidation and storage and glucose-induced thermogenesis were calculated.
  
  
  RESULTS
  Patients with cirrhosis had modestly elevated resting energy expenditure and normal glucose-induced thermogenesis and postprandial glucose oxidation and storage. These measures remained unchanged after liver transplantation despite a significant increase in postprandial glycemia. Patients, however, gained an average of 3 kg of body weight after 5 to 19 months compared with their weight before transplantation.
  
  
  CONCLUSIONS
  Liver denervation secondary to transplantation does not lead to alterations of energy metabolism after ingestion of a glucose load.
authors.affiliation: Institut de physiologie, 7 rue du Bugnon, CH-1005 Lausanne, Switzerland. Luc.Tappy@iphysiol.unil.ch
authors.forename: L
authors.initials: L
authors.lastname: Tappy
authors.forename: P
authors.initials: P
authors.lastname: Schneiter
authors.forename: R
authors.initials: R
authors.lastname: Chioléro
authors.forename: V
authors.initials: V
authors.lastname: Bettschart
authors.forename: M
authors.initials: M
authors.lastname: Gillet
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D004734:Energy Metabolism; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000294:innervation / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011300:Preoperative Care; D011446:Prospective Studies; D013997:Time Factors; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D005947:Glucose