title: Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast.
abstract: The authors describe what is, to the best of their knowledge, the first quantitative hemoglobin concentration images of the female breast that were formed with model-based reconstruction of near-infrared intensity-modulated tomographic data. The results in 11 patients, including two with breast tumors with pathologic correlation, are summarized. Hemoglobin concentration appears to correlate with tumor vascularity without the need for exogenous contrast material and thereby has intrinsic diagnostic value.
authors.affiliation: Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755-8000, USA.
authors.forename: B W
authors.initials: BW
authors.lastname: Pogue
authors.forename: S P
authors.initials: SP
authors.lastname: Poplack
authors.forename: T O
authors.initials: TO
authors.lastname: McBride
authors.forename: W A
authors.initials: WA
authors.lastname: Wells
authors.forename: K S
authors.initials: KS
authors.lastname: Osterman
authors.forename: U L
authors.initials: UL
authors.lastname: Osterberg
authors.forename: K D
authors.initials: KD
authors.lastname: Paulsen
mesh_terms: D000328:Adult; D001940:Breast; D001943:Breast Neoplasms / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis*; D004867:Equipment Design; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D019265:Spectroscopy, Near-Infrared; D014054:Tomography / Q000295:instrumentation
chemical_list: D006454:Hemoglobins