title: Unusual pattern of leukoencephalopathy after morphine sulphate intoxication.
abstract: We report a 14-year-old girl with an unusual pattern of leukoencephalopathy after intentional intoxication with morphine sulphate tablets. Toxicological analysis showed exceedingly high levels of morphine and its metabolites. MRI disclosed a leukoencephalopathy with high signal from the centrum semiovale, corpus callosum and cerebellar white matter on T2-weighted images. These findings could be only partially explained by a hypoxic-ischaemic event; neurotoxic effects must be considered in this atypical leukoencephalopathy.
authors.affiliation: Children's Hospital, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. KINK106@mail.uni-wuerzburg.de
authors.forename: R
authors.initials: R
authors.lastname: Nanan
authors.forename: H B
authors.initials: HB
authors.lastname: von Stockhausen
authors.forename: B
authors.initials: B
authors.lastname: Petersen
authors.forename: L
authors.initials: L
authors.lastname: Solymosi
authors.forename: M
authors.initials: M
authors.lastname: Warmuth-Metz
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications / Q000209:etiology; D005260:Female; D006801:Humans; D007962:Leukocytes; D008279:Magnetic Resonance Imaging; D009020:Morphine / Q000506:poisoning*; D009294:Narcotics / Q000506:poisoning*; D009336:Necrosis; D020258:Neurotoxicity Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology
chemical_list: D009294:Narcotics; D009020:Morphine