[Regulation and dysfunction of endothelium-dependent vasomotricity. What can be applied to clinical practice?].
FUNCTIONS OF THE ENDOTHELIUM: The endothelium plays a pivotal role in regulating vasomotor tone, vessel permeability, blood cell extravasation, and antiatherogenic, antithrombogenic and antiadhesive processes.
Demonstrated, in particular, by endothelium-dependent vasomotricity disorders, endothelium dysfunction occurs in many psysiological and pathological situations that lead to atherosclerosis: advanced age, menopause, high blood pressure, dyslipidemia, diabetes, smoking, elevated homocysteinemia, chronic renal failure.... These dysfunctions of the endothelium constitute the fundamental and very early step in the development of atherosclerosis.


CONCLUSIONS
Specific treatment of functional anomalies of the endothelium can be an essential element in the prevention of atherosclerosis. In certain cases, he cause of endothelial dysfunction may be related to the presence of radical oxygen species, nitric oxide inhibitors, or increased synthesis or release of endothelin. Potential treatments should be adapted to the specific cause of the underlying endothelial anomaly: antioxidants, statins, anti-endothelins, or converting enzyme inhibitors. In clinical practice, it may be important to recognize the cause of endothelial dysfunction for adapted early drug therapy.
Halimi
J M
JM
Service de Néphrologie-Immunologie clinique, Hôpital Bretonneau, CHU Tours, 2, bd Tonnellé, F 37044 Tours.
Lebranchu
Y
Y
D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D016232:Endothelins / Q000096:biosynthesis / Q000494:pharmacology; D004727:Endothelium / Q000502:physiology*; D005609:Free Radicals; D006801:Humans; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology; D014666:Vasomotor System / Q000473:pathology*
D016232:Endothelins; D005609:Free Radicals; D009569:Nitric Oxide