title: CD1 and lipid antigens: intracellular pathways for antigen presentation.
abstract: Recently, different members of the CD1 family of MHC-like molecules have been shown to sample different intracellular compartments to present lipid and glycolipid antigens to T cells. Emerging models suggest that CD1 may have evolved to monitor the integrity of membrane lipids and/or to present microbial lipid antigens to both alpha beta and gamma delta T cells.
authors.affiliation: Department of Molecular Biology, Schultz Laboratory, Room 416, Princeton University, Washington Road, Princeton, NJ 08544, USA.
authors.forename: J
authors.initials: J
authors.lastname: Jayawardena-Wolf
authors.forename: A
authors.initials: A
authors.lastname: Bendelac
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D018949:Antigens, CD1 / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007424:Intracellular Fluid / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D050356:Lipid Metabolism; D008055:Lipids / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology
chemical_list: D018949:Antigens, CD1; D008055:Lipids