title: Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE.
abstract: Article abstract-Alpha synuclein, tau, synphilin, and APOE genotypes were analyzed in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and controls. The predisposing effect of the tau insertion polymorphism to the development of PSP is confirmed. However, no effect of alpha-synuclein, synphilin, or APOE variability on the development of PSP, or of tau, alpha-synuclein, APOE, or synphilin gene variability on the development of MSA, are demonstrated.
authors.affiliation: Neurogenetics Section, University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
authors.forename: H R
authors.initials: HR
authors.lastname: Morris
authors.forename: J R
authors.initials: JR
authors.lastname: Vaughan
authors.forename: S R
authors.initials: SR
authors.lastname: Datta
authors.forename: R
authors.initials: R
authors.lastname: Bandopadhyay
authors.forename: H A
authors.initials: HA
authors.lastname: Rohan De Silva
authors.forename: A
authors.initials: A
authors.lastname: Schrag
authors.forename: N J
authors.initials: NJ
authors.lastname: Cairns
authors.forename: D
authors.initials: D
authors.lastname: Burn
authors.forename: U
authors.initials: U
authors.lastname: Nath
authors.forename: P L
authors.initials: PL
authors.lastname: Lantos
authors.forename: S
authors.initials: S
authors.lastname: Daniel
authors.forename: A J
authors.initials: AJ
authors.lastname: Lees
authors.forename: N P
authors.initials: NP
authors.lastname: Quinn
authors.forename: N W
authors.initials: NW
authors.lastname: Wood
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D019578:Multiple System Atrophy / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D013494:Supranuclear Palsy, Progressive / Q000235:genetics*; D051843:Synucleins; D051844:alpha-Synuclein; D016875:tau Proteins / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; C118958:SNCAIP protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D016875:tau Proteins