title: Use of hydroxyapatite to fill cavities after excision of benign bone tumours. Clinical results.
abstract: We treated 75 patients with benign bone tumours by curettage and filling the defect with calcium hydroxyapatite (HA). There were 28 women and 47 men with a mean age of 27.7 years (3 to 80). The mean follow-up was for 41.3 months. Postoperative radiological assessment revealed that the implanted HA was well incorporated into the surrounding host bone in all patients. Two patients suffered fractures in the postoperative period. Two patients complained of pain associated with HA in the soft tissues, but this diminished within six months. No patient had local pain at the final follow-up. Recurrence of the tumour was seen in three cases. Histopathological study of the implanted area showed removal of the HA by histiocytes and multinucleated giant cells, and the formation of much appositional bone. We conclude that HA is an excellent bone-graft substitute in surgery for benign bone tumours.
authors.affiliation: Department of Orthopaedic Surgery, Kobe University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Onga
authors.forename: T
authors.initials: T
authors.lastname: Marui
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000009:adverse effects / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003475:Curettage / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D017886:Durapatite / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000000981:diagnostic imaging / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D016348:Osseointegration; D010027:Osteotomy / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D010149:Postoperative Pain / Q000209:etiology; D013165:Splints; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite