New cytotoxic sesquiterpenes from the gorgonian Isis hippuris.
Five new suberosane sesquiterpenes, suberosenol A (1), suberosenol B (2), suberosanone (3), suberosenol A acetate (4), and suberosenol B acetate (5), along with the known sesquiterpene subergorgic acid (6), have been isolated from the gorgonian Isis hippuris. The structures of these metabolites were established by spectroscopic and chemical methods. Metabolites 1 and 3-5 were found to exhibit potent cytotoxicity toward P-388, A549, and HT-29 cancer cell lines.
Sheu
J H
JH
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China. sheu@mail.nsysu.edu.tw
Hung
K C
KC
Wang
G H
GH
Duh
C Y
CY
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D012717:Sesquiterpenes