Plasma endothelin-1 levels after stem cell transplantation.
Acute renal failure and veno-occlusive disease of the liver are serious complications following stem cell transplantation (SCT) and contribute to the non-relapse mortality associated with this procedure. Endothelins, a family of vasoconstrictor peptides, may be involved in the pathogenesis of a variety of renal and hepatic diseases, including CsA-associated hypertension and the hepatorenal syndrome. In order to study the relevance of endothelins to SCT-related liver and kidney dysfunction, we determined endothelin-1 (ET-1) levels in plasma samples obtained from 65 patients (38 autologous, 27 allogeneic) 7 days before and 7, 14 and 28 days after SCT. A steady increase in plasma ET-1 was observed after SCT (5.36 pg/ml, 95% CI 4.30-6.43 on day +28 vs 3.82 pg/ml, 95% CI 3.21-4.43 on day -7; P = 0.020). No differences in ET-1 levels existed between autologous and allogeneic SCT recipients at any of the time points studied (P = 0.561). In addition, no significant differences were observed among patients with renal dysfunction vs those without (P = 0.187), nor in patient groups with or without hepatic dysfunction (P = 0.075). In conclusion, even though plasma ET-1 levels showed a steady increase following SCT, no correlation could be found with development of SCT-related kidney or liver dysfunction.
Tomis
J F
JF
Department of Hematology, Hospital Universitario de la Princesa, Madrid, Spain.
Sanz-Rodriguez
C
C
de Soria
V G
VG
Font
P
P
Sánchez
S
S
Gruss
E
E
Figuera
A
A
Fernández-Rañada
J M
JM
D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology; D000293:Adolescent; D000328:Adult; D016572:Cyclosporine / Q000097:blood / Q000627:therapeutic use; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006504:Hepatic Veno-Occlusive Disease / Q000097:blood / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D019332:Endothelin-1; D007166:Immunosuppressive Agents; D016572:Cyclosporine