title: Experimental sensitization with Japanese cedar pollen in dogs.
abstract: Japanese cedar pollinosis is a type I allergic disease mediated by immunoglobulin E (IgE) antibodies to Japanese cedar (Cryptomeria japonica) pollen antigen (CPAg). By using 22 dogs consisting of 20 dogs aged 3 months and 2 dogs aged 3 years, immunization was performed by subcutaneous injections of CPAg with aluminum hydroxide gel. Variable levels of CPAg-specific IgE antibody response were detected in 21 of the 22 immunized dogs two weeks after the second immunization. This study provided an experimental sensitization system with CPAg in dogs, which will be useful for further immunological studies on Japanese cedar pollinosis.
authors.affiliation: Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd., Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: K
authors.initials: K
authors.lastname: Masuda
authors.forename: M
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: T
authors.initials: T
authors.lastname: Odagiri
authors.forename: Y
authors.initials: Y
authors.lastname: Nakao
authors.forename: M
authors.initials: M
authors.lastname: Yamaki
authors.forename: A
authors.initials: A
authors.lastname: Hasegawa
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.forename: D J
authors.initials: DJ
authors.lastname: Deboer
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000818:Animals; D000917:Antibody Formation; D032462:Cycadopsida; D004285:Dogs; D005260:Female; D006967:Hypersensitivity / Q000276:immunology / Q000662:veterinary*; D007114:Immunization / Q000662:veterinary*; D007073:Immunoglobulin E / Q000097:blood*; D007564:Japan; D008297:Male; D011058:Pollen / Q000276:immunology*; D014197:Trees
chemical_list: D007073:Immunoglobulin E