title: Fast-track cardiac anesthesia: a comparison of remifentanil plus intrathecal morphine with sufentanil in a desflurane-based anesthetic.
abstract: OBJECTIVE
  To compare the effects of an intravenous remifentanil infusion plus intrathecal morphine with intravenous sufentanil infusion with respect to intraoperative hemodynamic variables, extubation times, and recovery profiles when administered as part of a desflurane-based fast-track anesthetic regimen for cardiac surgery.
  
  
  METHODS
  A prospective, randomized, nonblinded study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Forty patients undergoing elective primary coronary artery bypass graft, aortic valve replacement, or mitral valve replacement surgery.
  
  
  METHODS
  After a standardized anesthetic induction, anesthesia was maintained with a remifentanil infusion, 0.1 microg/kg/min, and desflurane, 3% to 10%, inspired (group I, n = 20) or a sufentanil infusion, 0.3 microg/kg/h, and desflurane, 3% to 10%, inspired (group II, n = 20). Patients receiving remifentanil were administered intrathecal morphine, 8 microg/ kg, for postoperative analgesia.
  
  
  RESULTS
  Both anesthetic regimens provided comparable intraoperative hemodynamic stability and similar recovery profiles, with extubation times of 5.1 +/- 4.3 hours (group I) and 5.8 +/- 6.7 hours (group II).
  
  
  CONCLUSIONS
  Use of remifentanil in combination with intrathecal morphine did not facilitate earlier tracheal extubation or improve intraoperative hemodynamic stability compared with sufentanil alone for fast-track cardiac anesthesia.
authors.affiliation: Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, 75235-9068, USA.
authors.forename: P
authors.initials: P
authors.lastname: Latham
authors.forename: E
authors.initials: E
authors.lastname: Zarate
authors.forename: P F
authors.initials: PF
authors.lastname: White
authors.forename: R
authors.initials: R
authors.lastname: Bossard
authors.forename: C
authors.initials: C
authors.lastname: Shi
authors.forename: L S
authors.initials: LS
authors.lastname: Morse
authors.forename: L K
authors.initials: LK
authors.lastname: Douning
authors.forename: L
authors.initials: L
authors.lastname: Chi
mesh_terms: D000759:Adjuvants, Anesthesia; D000368:Aged; D000701:Analgesics, Opioid; D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation; D006348:Cardiac Surgical Procedures; D000077335:Desflurane; D004569:Electroencephalography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007530:Isoflurane / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D009020:Morphine; D010880:Piperidines; D011446:Prospective Studies; D000077208:Remifentanil; D017409:Sufentanil
chemical_list: D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D018685:Anesthetics, Inhalation; D010880:Piperidines; D009020:Morphine; D017409:Sufentanil; D000077335:Desflurane; D007530:Isoflurane; D000077208:Remifentanil