title: Nitroimidazoles and hypoxia imaging: synthesis of three technetium-99m complexes bearing a nitroimidazole group: biological results.
abstract: Several Tc-99m complexes were synthesized, substituted with a nitroimidazole group, in order to visualize hypoxic tissues. The complexes were tested on rats (isolated hearts) and showed no significant uptake under hypoxic conditions.
authors.affiliation: Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité, Université Joseph Fourier, UMR 5616-BP 53, Grenoble, France. francoise.riche@ujf-grenoble.fr
authors.forename: F
authors.initials: F
authors.lastname: Riché
authors.forename: A D
authors.initials: AD
authors.lastname: d'Hardemare
authors.forename: S
authors.initials: S
authors.lastname: Sèpe
authors.forename: L
authors.initials: L
authors.lastname: Riou
authors.forename: D
authors.initials: D
authors.lastname: Fagret
authors.forename: M
authors.initials: M
authors.lastname: Vidal
mesh_terms: D000818:Animals; D006321:Heart / Q000000981:diagnostic imaging / Q000503:physiopathology; D000860:Hypoxia / Q000000981:diagnostic imaging*; D066298:In Vitro Techniques; D008024:Ligands; D015394:Molecular Structure; D009593:Nitroimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010477:Perfusion; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000378:metabolism; D017556:Technetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D008024:Ligands; D009593:Nitroimidazoles; D017556:Technetium Compounds; D013667:Technetium