History and use of oxytocics.
The most widely known oxytocic drug that can be used for the induction of labor or post-partum is oxytocin. In 1954, the american biochemist Vincent du Vigneaud was the first to describe an octapeptide amide with the hormonal activity of oxytocin. One year later, he was able to synthesize this octapeptide amide. In the same year he received the Nobel prize for his work in the field of biochemistry. A reprint of his brilliant publication is reproduced [with kind permission of the editors of the J Am Chem Soc]. With slight changes in structure, du Vigneaud was able to synthesize not only oxytocin, but also vasopressin. In our paper, however, we will focus on oxytocin only, as it is this synthetic hormone that has gained considerable importance in obstetrics. It is used for prevention of PPH as well as for induction of labour.
den Hertog
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CE
Department of Obstetrics and Gynaecology, University Hospital Nijmegen, St. Radboud, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. g.theunissen@obgyn.azn.nl
de Groot
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AN
van Dongen
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D005260:Female; D049669:History, 16th Century; D049673:History, 20th Century; D006801:Humans; D007751:Labor, Induced; D010120:Oxytocics / Q000266:history* / Q000627:therapeutic use*; D010121:Oxytocin / Q000266:history / Q000627:therapeutic use; D011247:Pregnancy; D014592:Uterine Hemorrhage / Q000517:prevention & control
D010120:Oxytocics; D010121:Oxytocin