title: Expedited human immunodeficiency virus testing of mothers and newborns with unknown HIV status at time of labor and delivery.
abstract: New York State introduced the first statewide program in the U.S. of expedited HIV testing (48-hour turn-around results) of mothers with unknown HIV status at the time of labor or delivery and their newborns on August 1, 1999. We evaluated the results of this program during its first 5 months at Lincoln Medical and Mental Health Center (Lincoln Hospital) in the Bronx, New York. There were 1,274 total live birth deliveries between August 1 and December 31, 1999. The HIV infection status of 539 mothers (42.3%) was unknown to medical providers in the labor-delivery suite, either due to lack of testing during the current pregnancy or unavailability of HIV documentation at the time of delivery. During labor and delivery, a total of 462 (85.7%) mothers with unknown HIV status consented to expedited HIV testing (Single Use Diagnostic System for HIV-1 antibody or SUDS). The newborns of 77 mothers (14.3%) who did not consent were tested immediately after birth. Seventeen tested positive for HIV-1 antibody by the SUDS test. The results of 10 of these infants (58.8%) were subsequently confirmed positive for HIV-1 antibody by Western Blot analysis. This new rapid HIV testing program facilitated early diagnosis of these previously unknown HIV-exposed infants, although the low positive predictive value of the test in our community calls for careful communication of these results pending confirmation.
authors.affiliation: Department of Pediatrics, Lincoln Medical and Mental Health Center, Bronx, New York, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Rajegowda
authors.forename: B B
authors.initials: BB
authors.lastname: Das
authors.forename: R
authors.initials: R
authors.lastname: Lala
authors.forename: S
authors.initials: S
authors.lastname: Rao
authors.forename: D F
authors.initials: DF
authors.lastname: Mc Neeley
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000635:transmission; D015153:Blotting, Western; D036861:Delivery, Obstetric; D005189:False Positive Reactions; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000175:diagnosis*; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007743:Labor, Obstetric; D009518:New York; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology; D011295:Prenatal Care; D019966:Substance-Related Disorders
chemical_list: D015483:HIV Antibodies