Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: a new class of GABA(A) brain receptor ligands.
A novel class of potent benzodiazepine receptor (BZR) ligands has been designed and synthesized aided by molecular modeling of known benzodiazepine ligands such as CGS-8216 and the use of known pharmacophore models.
DeSimone
R W
RW
Neurogen Corporation, Branford, CT 06405, USA.
Blum
C A
CA
D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000378:metabolism*; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000378:metabolism*; D001923:Brain Chemistry; D018755:GABA Agonists / Q000138:chemical synthesis / Q000378:metabolism; D018756:GABA Antagonists / Q000138:chemical synthesis / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D010080:Oxazoles / Q000138:chemical synthesis / Q000378:metabolism*; D011485:Protein Binding; D011720:Pyrazoles / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism*; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; D018755:GABA Agonists; D018756:GABA Antagonists; D008024:Ligands; D010080:Oxazoles; D011720:Pyrazoles; D011963:Receptors, GABA-A; D001569:Benzodiazepines; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one