title: Expression of atrial natriuretic factor (ANF) during Xenopus cardiac development.
abstract: We have isolated the Xenopus orthologue of the atrial natriuretic factor (ANF) gene. Characterization of embryonic expression indicates that the ANF gene is initially expressed throughout the developing myocardium at the late heart tube stage (about stage 32). This is in contrast to all previously characterized Xenopus cardiac differentiation markers that are first expressed in the cardiogenic plate at approximately stage 27. ANF expression becomes restricted exclusively to the atrium at about stage 47, long after the commencement of beating and the original formation of the atrial and ventricular compartments, but shortly after septation of the single atrium into two distinct atria.
authors.affiliation: Department of Cell Biology and Anatomy, University of Arizona Health Science Center, P.O. Box 245044, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA.
authors.forename: E M
authors.initials: EM
authors.lastname: Small
authors.forename: P A
authors.initials: PA
authors.lastname: Krieg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000737:chemistry / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014981:Xenopus / Q000196:embryology*
chemical_list: D009320:Atrial Natriuretic Factor