Enantioselective Michael addition of nitromethane to alpha, beta-enones catalyzed by chiral quaternary ammonium salts. A simple synthesis of (R)-baclofen.
[reaction:see text] Enantioselective Michael addition of nitromethane to an alpha, beta-enone is a key step in the synthesis of (R)-baclofen.
Corey
E J
EJ
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. corey@chemistry.harvard.edu
Zhang
F Y
FY
D001418:Baclofen / Q000138:chemical synthesis*; D002384:Catalysis; D015394:Molecular Structure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012492:Salts; D013237:Stereoisomerism
D000644:Quaternary Ammonium Compounds; D012492:Salts; D001418:Baclofen