Intracranial fibrosarcoma arising 5 years after chemotherapy alone for glioblastoma multiforme in a child.
We present a child diagnosed with glioblastoma multiforme during infancy and successfully treated with the 'eight-in-one' chemotherapy regimen, who developed an intracranial fibrosarcoma 5 years later. After resection of the fibrosarcoma, she received cranial radiation therapy and high dose chemotherapy with bone marrow transplant. She remains alive and recurrence-free 7 years following the diagnosis of her second intracranial malignancy.
Kaminski
J M
JM
Department of Radiation Oncology, Fox Chase Cancer Center, Albert Einstein Medical Center, Philadelphia, Pa., USA. jm.kaminski@fccc.edu
Yang
C C
CC
Yagmai
F
F
Movsas
B
B
Lee
M
M
Barrett
J T
JT
D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology* / Q000628:therapy; D005625:Frontal Lobe / Q000473:pathology* / Q000601:surgery; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy; D009778:Occipital Lobe / Q000473:pathology* / Q000601:surgery; D013997:Time Factors