Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor.
Three new 2-phenyl-benzofurans, ebenfuran I, ebenfuran II, and ebenfuran III, were isolated from Onobrychis ebenoides. Their structures were elucidated on the basis of chemical and spectral data as 2-(2,4-dihydroxyphenyl)-5-hydroxy-6-methoxy-benzofuran (1), 2-(2,4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-methoxy-benzofuran (2), and 2-(2, 4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-methoxy-5-(3-methyl-buten- 2-y l)-benzofuran (3). The affinity of these compounds for the estrogen receptor was studied using a receptor-binding assay.
Halabalaki
M
M
Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens, Panepistimiopolis, Zografou, GR-15771, Athens, Greece.
Aligiannis
N
N
Papoutsi
Z
Z
Mitakou
S
S
Moutsatsou
P
P
Sekeris
C
C
Skaltsounis
A L
AL
D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D007887:Fabaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal; D011485:Protein Binding; D011960:Receptors, Estrogen / Q000378:metabolism*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
C000592622:2-(2,4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-methoxy-5-(3-methylbuten-2-yl)benzofuran; D001572:Benzofurans; D011960:Receptors, Estrogen; D012118:Resorcinols