Bioactive fatty acids: role in bone biology and bone cell function.
Bone is a unique tissue providing support, movement, and mineral balance for the body. Bone growth is achieved in the young by a process called modeling, and maintained during adulthood by a process termed remodeling. Three types of cells are responsible for the formation of cartilage and bone; the chondrocyte, osteoblast, and osteoclast. These cells are under the influence of a plethora of regulatory molecules, which govern their action to provide an individual optimal bone mass. Interruption of this homeostatic machinery, especially in the elderly, often results in a loss of bone mass (osteoporosis) or cartilage damage (rheumatoid arthritis). Many pharmacological agents have been made available in an effort to prevent or alleviate these pathologies, however, one vector often overlooked is the diet. This review focuses on the relationship between dietary polyunsaturated fatty acids and bone biology, both in vivo and in vitro.
Watkins
B A
BA
Department of Food Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, 47907, West Lafayette, IN, USA
Lippman
H E
HE
Le Bouteiller
L
L
Li
Y
Y
Seifert
M F
MF
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism; D001846:Bone Development; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D019902:Chondrocytes / Q000378:metabolism; D016207:Cytokines / Q000502:physiology; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000502:physiology; D005231:Fatty Acids, Unsaturated / Q000502:physiology*; D006801:Humans; D008041:Linoleic Acids / Q000502:physiology; D008875:Middle Aged; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism
D016207:Cytokines; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids