Effect of subthalamic nucleus stimulation on levodopa-induced dyskinesia in Parkinson's disease.
Article abstract-The authors studied the effect of bilateral subthalamic nucleus stimulation on levodopa-induced dyskinesias in 24 consecutive parkinsonian patients with disabling dyskinesias. The improvement in the three subtypes of levodopa-induced dyskinesias was significant from the third postoperative month and was mainly due to the decrease in the daily dose of levodopa allowed by the stimulation-induced improvement in the motor score.
Fraix
V
V
Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University, France.
Pollak
P
P
Van Blercom
N
N
Xie
J
J
Krack
P
P
Koudsie
A
A
Benabid
A L
AL
D000328:Adult; D000368:Aged; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D013787:Thalamic Nuclei / Q000503:physiopathology*
D007980:Levodopa