title: Stress management - heat shock protein-70 and the regulation of apoptosis.
abstract: Apoptosis, molecularly regulated cell death, can be induced by a range of environmental, physical or chemical stresses, and is characterized by a sequence of precisely regulated events that culminate in the self-destruction of a cell. Fascinating biochemical and genetic parallels exist between the cell death pathways of different animal species. However, an even more highly conserved and evolutionarily ancient cellular response can be engaged as a consequence of stress, which functions to maintain cellular survival. This response is mediated by the heat-shock or stress proteins. This article discusses the functional interactions between the stress response and the apoptotic cell death pathway and how these might impact on determining cellular survival.
authors.affiliation: La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, 92121, San Diego, CA, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Beere
authors.forename: D R
authors.initials: DR
authors.lastname: Green
mesh_terms: D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology*; D006801:Humans
chemical_list: D018840:HSP70 Heat-Shock Proteins