[Features of the modulating effect of complexes of ribosome-inactivating proteins type II with sugars on respiratory burst of neturophils, caused by a chemotactic peptide].
It was shown that agents inducing phagocytosis (zymosan, lectins) cause changes in the number of receptors responsible for fast neutrophil reaction (chemotaxis or respiratory burst) or inhibit the binding of the agonist to its receptor. Among lectins are ribosome-inactivating proteins of type II ricin and agglutinin ricin, which penetrate the cell by binding to mannose and galactose receptors. It was shown that ribosome-inactivating proteins of type II can exhibit the properties of the antagonist of the receptor N-formylmethionylleucylphenylalanine. Ricin is more effective in modulating the respiratory burst induced by the chemotactic peptide than agglutinin ricin. The modulating effect of ribosome-inactivating proteins of type II on neutrophils is likely to be mediated by their interaction with galactose rather than mannose receptors. Presumably, the affinity of ribosome-inactivating proteins to galactose receptors increases with increasing amount of saccharides bound to the protein molecule. The modulating effect of ribosome-inactivating proteins of type II on the respiratory burst of neutrophils induced the chemotactic peptide is due to the structural peculiarities of these proteins.
Alovskaia
A A
AA
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia.
Safronova
V G
VG
Kornilov
V V
VV
Kornev
A N
AN
Bulakh
Iu A
IuA
Agapov
I I
II
Tonevitskiĭ
A G
AG
Voelter
W
W
Betzel
K
K
Mikhaĭlov
A M
AM
D002241:Carbohydrates / Q000737:chemistry* / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D008163:Luminescent Measurements; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects; D012270:Ribosomes / Q000187:drug effects*; D012276:Ricin / Q000737:chemistry* / Q000494:pharmacology
D002241:Carbohydrates; D009240:N-Formylmethionine Leucyl-Phenylalanine; D012276:Ricin