Giraffe strain of pestivirus: its taxonomic status based on the 5'-untranslated region.
The 5'-untranslated region (5'-UTR) of the 'Giraffe' strain of pestivirus was sequenced for comparison with those of other pestiviruses from cattle, sheep, goats, and swine. A phylogenetic tree constructed with these strains suggested that the 'Giraffe' strain was allocated to a new taxon. This observation was also confirmed by a newly proposed method based on palindromic nucleotide substitutions (PNS) at the three variable regions in the 5'-UTR. Other reported pestivirus strains isolated from deer were assigned as bovine viral disease virus (BVDV)-1 according to the PNS as well as phylogenetic analysis, suggesting that BVDV-1 strains can cross-infect deer as well as cattle, sheep, goats, and swine, and that wild deer may serve as a reservoir of BVDV-1. We also identified the genovar of a deer isolate, SH9/11, as BVDV-1c by the PNS method.
Harasawa
R
R
Animal Center for Biomedical Research, Faculty of Medicine, The University of Tokyo, Japan. ryo@m.u-tokyo.ac.jp
Giangaspero
M
M
Ibata
G
G
Paton
D J
DJ
D020121:5' Untranslated Regions; D000818:Animals; D001188:Artiodactyla / Q000821:virology*; D020029:Base Pairing; D001483:Base Sequence; D003670:Deer / Q000821:virology; D016679:Genome, Viral; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D010576:Pestivirus / Q000235:genetics*; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D016415:Sequence Alignment
D020121:5' Untranslated Regions