title: A report of the clinical use of the detach-18 mechanical detachable platinum coil in 41 patients.
abstract: OBJECTIVE
  The purpose of this study was to determine the safety and reliability of the mechanical detachment system of a new platinum coil, Detach-18, when used as a vascular occlusive device for neurovascular disease.
  
  
  METHODS
  Forty-one patients (nine male and 32 female patients; age range, 26-75 years; mean age, 54.4 years) underwent treatment at seven centers. Twenty-two patients had dural arteriovenous fistulae of the transverse sinus treated by a transvenous route. Fourteen patients underwent internal carotid artery occlusion in the treatment of aneurysms, meningioma, facial tumor, or carotid injury. One patient underwent occlusion of the basilar artery and one patient underwent occlusion of the vertebral artery for treatment of aneurysms. In two patients, coils were used as part of the treatment of their arteriovenous malformations. In all cases, the Detach-18 coils were delivered through a microcatheter with two distal markers. Two types of coils, a 0.015-inch-diameter "regular" coil and a 0.014-inch-diameter "soft" coil, were used.
  
  
  RESULTS
  A total of 569 coils were used, 541 of which were detached. The number of coils in ranged from four to 53 (average number of coils, 14). The coils passed easily through the microcatheter. The detachment maneuver occurred within 10 to 25 s with 20 turns of the introducing wire. No premature coil detachment occurred. Complete occlusion of the vessel lumen was achieved in 35 cases. In three cases, 80% to 90% occlusion was achieved. In two cases, 70% to 80% occlusion was achieved. There were no device-related complications.
  
  
  CONCLUSIONS
  The detachment system was safe, reliable, consistent, and fast. This is a useful system for coil embolization in neurovascular applications.
authors.affiliation: Division of Diagnostic and Interventional Radiology, Geneva University Hospital, Switzerland.
authors.forename: K J
authors.initials: KJ
authors.lastname: Murph
authors.forename: E
authors.initials: E
authors.lastname: Houdart
authors.forename: K T
authors.initials: KT
authors.lastname: Szopinski
authors.forename: O
authors.initials: O
authors.lastname: Levrier
authors.forename: L
authors.initials: L
authors.lastname: Guimaraens
authors.forename: D
authors.initials: D
authors.lastname: Kühne
authors.forename: L
authors.initials: L
authors.lastname: Solymosi
authors.forename: N J
authors.initials: NJ
authors.lastname: Bartholdy
authors.forename: K
authors.initials: K
authors.lastname: Sugiu
authors.forename: D A
authors.initials: DA
authors.lastname: Rüfenacht
mesh_terms: D000328:Adult; D000368:Aged; D002343:Carotid Artery, Internal; D002533:Cerebral Angiography; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000628:therapy; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy; D010984:Platinum
chemical_list: D010984:Platinum