title: Pathologic changes, mechanisms and diagnosis in renal bone disease.
abstract: OBJECTIVE
  To investigate the incidence rate, pathologic changes, mechanisms and diagnostic methods in renal bone disease.
  
  
  METHODS
  The blood levels of carboxyterminal parpthyriod hormone (C-PTH), 1,25(OH)2D3, calcium and phosphate, aluminum in serum and bone tissue were measured. The bone biopsy and bone scan with 99m technetium methylene diphosphonate (99mTC-MDP) were performed in 51 uremic patients.
  
  
  RESULTS
  One hundred per cent of the patients had varying degree of pathologic changes in bone, in which 50.9% of the patients presented high-turnover bone disease, 7.8% of the patients presented low-turnover bone disease and 41.8% of the patients had mixed-type bone disease. The levels of serum C-PTH were predominently high in high-turnover bone disease while the levels of serum 1,25(OH)2D3 were significantly decreased in low-turnover bone disease. There was a high positive rate for the diagnosis of renal bone disease by bone scan with 99mTC-MDP.
  
  
  CONCLUSIONS
  The examination of bone pathology is the most valuable method for the diagnosis of renal bone disease. Bone scan with 99mTC-MDP has reference value when clinical conditions do not allow to make bone biopsy.
authors.affiliation: Department of Nephrology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China.
authors.forename: P
authors.initials: P
authors.lastname: Zhu
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: D
authors.initials: D
authors.lastname: Lou
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Jia
authors.forename: D
authors.initials: D
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications; D006801:Humans; D007085:Ilium / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D014511:Uremia / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D013669:Technetium Tc 99m Medronate