Animal models of allergic rhinitis.
Actively sensitized Brown Norway rats and guinea pig are useful species for studying drug effects on symptoms of experimental rhinitis. Even if not all symptoms of human rhinitis can be induced and detected in the same animal species, the predictablity of methods generally used is well acceptable. In the present review, advantages and disadvantages of experimental methods of rhinitis will be discussed.
Szelenyi
I
I
Department Pulmonary Pharmacology, Corporate Research & Development, ASTA Medica AG, Radebeul and Halle-Künsebeck, Germany. stefan.szelenyi@astamedica.de
Marx
D
D
Jahn
W
W
D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D004285:Dogs; D005289:Ferrets; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D011817:Rabbits; D051381:Rats; D011914:Rats, Inbred BN; D017208:Rats, Wistar; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D012756:Sheep