title: A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents.
abstract: A convenient synthesis of nonsymmetrical bivalent inhibitors of the serotonin transporter is described. The synthesis utilizes polymer-supported reagents that allow for rapid access to novel bivalent ligands without the need for isolation or purification of synthetic intermediates.
authors.affiliation: Department of Neurology, Georgetown University Medical Center, Washington, DC 20007-2197, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Tamiz
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: K M
authors.initials: KM
authors.lastname: Johnson
authors.forename: A P
authors.initials: AP
authors.lastname: Kozikowski
mesh_terms: D000818:Animals; D003432:Cross-Linking Reagents; D003959:Diamines / Q000138:chemical synthesis / Q000378:metabolism; D008024:Ligands; D011108:Polymers; D011485:Protein Binding; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D003432:Cross-Linking Reagents; D003959:Diamines; D008024:Ligands; D011108:Polymers; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D017367:Selective Serotonin Reuptake Inhibitors