title: Diastereoselective vinyl addition to chiral hydrazones via tandem thiyl radical addition and silicon-tethered cyclization
abstract: A diastereoselective method for addition of a vinyl group to alpha-hydroxy hydrazones under neutral tin-free radical cyclization conditions, leading to substituted vinylglycinols, is presented. Tandem thiyl radical addition/cyclization upon a silicon-tethered vinyl group followed by treatment with potassium fluoride accomplishes a one-pot neutral vinyl addition process to afford acyclic allylic anti-hydrazino alcohols in good yield.
authors.affiliation: Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA.
authors.initials: GK
authors.lastname: Friestad
authors.initials: SE
authors.lastname: Massari