title: Xanthine oxidase-derived reactive oxygen species activate nuclear factor kappa B during hepatic ischemia in rats.
abstract: The present study was carried out to elucidate the relationship between the generation of reactive oxygen species (ROS) and an activation of nuclear factor (NF) kappa B in a hepatic ischemia-reperfusion model. During the ischemic period, the contents of xanthine oxidase (XOD) metabolites and thiobarbituric acid-reactive substances were significantly increased, and NF-kappa B was activated in the liver of rats. The activation of NF-kappa B was inhibited by pretreatment of allopurinol (10-100 mg/kg, i.p.) in a dose-dependent manner. In conclusion, this suggests that the XOD-derived ROS may activate NF-kappa B during ischemia.
authors.affiliation: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima city, Tokushima, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Matsui
authors.forename: I
authors.initials: I
authors.lastname: Satsuki
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Inaizumi
authors.forename: K
authors.initials: K
authors.lastname: Kasajima
authors.forename: R
authors.initials: R
authors.lastname: Kanoh
authors.forename: N
authors.initials: N
authors.lastname: Fukuishi
authors.forename: M
authors.initials: M
authors.lastname: Akagi
mesh_terms: D000818:Animals; D007511:Ischemia / Q000378:metabolism*; D008099:Liver / Q000098:blood supply*; D008297:Male; D016328:NF-kappa B / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D014969:Xanthine Oxidase