Association between apolipoprotein E genotypes and cancer risk in patients with acquired immunodeficiency syndrome.
The apolipoprotein E (apoE) genotype was determined in 197 deceased acquired immunodeficiency syndrome (AIDS) patients treated at Ullevaal Hospital in Oslo, Norway. A full autopsy had been performed on all. Cancer had developed in 71 individuals, mainly lymphomas (46) and Kaposi's sarcomas (18). The apoE genotype distribution was consistent with Hardy-Weinberg equilibrium, and allele frequencies were in the typical Scandinavian range (6.9% apoE2; 75.6% apoE3; and 17.5% apoE4). Cancer cases had a significantly higher frequency of apoE4 alleles than noncancer cases (24.6% and 13.5%, respectively) and a lower frequency of apoE2 alleles (3.5% versus 8.7%). Background factors, such as survival from AIDS diagnosis, could not explain these differences. Our study thus indicates that apoE genotype affects the development of cancers among AIDS patients.
Liestøl
K
K
Department of Informatics, University of Oslo, Norway.
Kvittingen
E A
EA
Rootwelt
H
H
Dunlop
O
O
Goplen
A K
AK
Pedersen
J C
JC
Brorson
S H
SH
Børresen-Dale
A L
AL
Myrvang
B
B
Maehlen
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000235:genetics*; D000328:Adult; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000235:genetics*; D008297:Male; D012514:Sarcoma, Kaposi / Q000235:genetics*
D001057:Apolipoproteins E