6-(hydroxyalkyl)penicillanates as probes for mechanisms of beta-lactamases.
6-(Hydroxyalkyl)penicillanates have proven helpful as probes for the mechanisms of beta-lactamases, enzymes of resistance for beta-lactam antibiotics. The present report summarizes the concepts on design, syntheses and use of these molecules in mechanistic studies of beta-lactamases.
Golemi
D
D
Department of Chemistry and Institute for Drug Design, Wayne State University, Detroit, MI 48202-3489, USA.
Maveyraud
L
L
Ishiwata
A
A
Tranier
S
S
Miyashita
K
K
Nagase
T
T
Massova
I
I
Mourey
L
L
Samama
J P
JP
Mobashery
S
S
D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015335:Molecular Probes; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013379:Substrate Specificity; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000737:chemistry / Q000378:metabolism*
D004791:Enzyme Inhibitors; D015335:Molecular Probes; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D001618:beta-Lactamases