title: The monoethylglycinexylidide (MEGX) test as a marker of hepatic dysfunction in septic patients with pneumonia.
abstract: The aim of this study was to monitor hepatic function in patients with pneumonia meeting the sepsis criteria of the American College of Chest Physicians/Society of Critical Care Medicine (ACCP/SCCM) and to determine if hepatic dysfunction is related to the systemic inflammatory response. Twenty patients were recruited. The monoethylglycinexylidide (MEGX) test was carried out on days 1-10 after admittance to the intensive care unit. Blood samples for determination of serum concentrations of hyaluronic acid, C-reactive protein (CRP), interleukin (IL)-6, IL-8, IL-10 and conventional liver function tests (aspartate aminotransferase, alanine aminotransferase, bilirubin, albumin) were also drawn. Patients were classified into two groups according to illness severity estimated by the simplified acute physiology score (SAPS II) on the day of admission. Patients in group I (n=10) had a SAPS II probability of mortality >3% while those in group II (n=10) had a SAPS II < 3%. The MEGX level over the first five days was significantly lower in group I than in group II (p<0.0001). Significant inverse correlations during the first 5 days were observed between the MEGX 30 min test results and IL-6, CRP and SAPS II and more modest correlations with hyaluronic acid (p=0.0025) and IL-10 (p=0.021). The conventional liver function tests did not differ between the two groups and were mostly within the respective reference ranges. We conclude that the MEGX test is a sensitive marker of liver dysfunction early in sepsis and that low MEGX values are associated with an enhanced inflammatory response.
authors.affiliation: Department of Clinical Pharmacology, I.M. Sechenov Medical Academy, Moscow, Russia. igonin@stk.mmtel.ru
authors.forename: A A
authors.initials: AA
authors.lastname: Igonin
authors.forename: V W
authors.initials: VW
authors.lastname: Armstrong
authors.forename: M
authors.initials: M
authors.lastname: Shipkova
authors.forename: V G
authors.initials: VG
authors.lastname: Kukes
authors.forename: M
authors.initials: M
authors.lastname: Oellerich
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000097:blood*; D008099:Liver / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications / Q000503:physiopathology*; D018805:Sepsis / Q000150:complications / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D008012:Lidocaine; C001173:monoethylglycinexylidide