title: [Acute cholestatic hepatitis induced by propylthiouracil. Case report].
abstract: Propylthiouracil is widely used to treat patients with hyperthyroidism. However, propylthiouracil-induced hepatitis is an uncommon entity. The case of a 15-year-old boy treated with propylthiouracil for hyperthyroidism who developed a cholestatic acute hepatitis is reported. Viral, metabolic and autoimmune liver diseases were excluded and liver biopsy showed a pattern suggestive of drug-induced cholestatic hepatitis. After discontinuing the drug, there was a progressive resolution of symptoms and normalization of liver biochemical tests. Despite its rarity, patients receiving propylthiouracil are exposed to develop severe hepatotoxicity.
authors.affiliation: Serviço de Transplante Hepático e Serviço de Anatomia Patológica, Hospital de Clínicas da Universidade Federal do Paraná HC-UFPR.
authors.forename: M B
authors.initials: MB
authors.lastname: Parolin
authors.forename: R W
authors.initials: RW
authors.lastname: Lopes
authors.forename: J E
authors.initials: JE
authors.lastname: Telles
authors.forename: S O
authors.initials: SO
authors.lastname: Ioshii
authors.forename: N
authors.initials: N
authors.lastname: Hajar
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008111:Liver Function Tests; D008297:Male; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil