Myelopathy following influenza vaccination in inflammatory CNS disorder treated with chronic immunosuppression.
We report a patient who developed a transverse myelitis with Brown-Séquard syndrome following a prophylactic influenza vaccination, despite being chronically immunosuppressed for a steroid-responsive optic neuropathy. Although influenza vaccination is recommended in patients receiving chronic immunosuppression, its use may on occasion be associated with neurological complications previously reported in immunocompetent individuals.
Larner
A J
AJ
Department of Neurology, St Mary's Hospital, Praed Street, London, UK. larner-a@wcnn-tr.nwest.nhs.uk
Farmer
S F
SF
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D018437:Brown-Sequard Syndrome / Q000175:diagnosis / Q000209:etiology*; D002574:Cervical Vertebrae; D004347:Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007252:Influenza Vaccines / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009187:Myelitis / Q000175:diagnosis / Q000209:etiology*; D009900:Optic Nerve / Q000473:pathology; D009901:Optic Nerve Diseases / Q000188:drug therapy*; D013116:Spinal Cord / Q000473:pathology; D014792:Visual Acuity
D007166:Immunosuppressive Agents; D007252:Influenza Vaccines; D001379:Azathioprine; D008775:Methylprednisolone