title: Possibilities of sterility therapy in a patient with a premature menopause due to an X-chromosomal anomaly - a case report.
abstract: Our report concerns a patient with a climacterium praecox and an X-chromosomal anomaly (86% 46, XX; 7% 47, XXX; 7% 45, X0) desiring to give birth. She conceived once after down-regulation of the gonadotrophins by means of a cyclical hormone replacement therapy followed by gonadotrophin stimulation, as well as a second time under down-regulation with a GnRH-analogue and gonadotrophin stimulation. On the basis of the case report and of the literature, a possible interval therapy in such a patient, especially one even with increasing ovarian insufficiency, will be portrayed and discussed.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Cologne, Kerpener Str. 34, D-50931, Cologne, Germany. frank.nawroth@medizin.uni-koeln.de
authors.forename: F
authors.initials: F
authors.lastname: Nawroth
authors.forename: D
authors.initials: D
authors.lastname: Foth
authors.forename: P
authors.initials: P
authors.lastname: Stute
authors.forename: T
authors.initials: T
authors.lastname: Schmidt
authors.forename: T
authors.initials: T
authors.lastname: Römer
mesh_terms: D000328:Adult; D015536:Down-Regulation; D004958:Estradiol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000502:physiology; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics; D008596:Menotropins / Q000627:therapeutic use*; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000150:complications / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D014960:X Chromosome
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D008596:Menotropins