Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency.
Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.
Wolf
D G
DG
Department of Clinical Microbiology and Infectious Diseases, Hadassah University Hospital, Jerusalem, and Schneider Children Medical Center, Petach Tiqva, Israel. wolfd@md2.huji.ac.il
Yaniv
I
I
Ashkenazi
S
S
Honigman
A
A
D019943:Amino Acid Substitution; D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics*; D004352:Drug Resistance, Microbial; D005260:Female; D015774:Ganciclovir / Q000494:pharmacology*; D017353:Gene Deletion; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D007223:Infant; D009154:Mutation / Q000235:genetics; D016511:Severe Combined Immunodeficiency / Q000821:virology*; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D015774:Ganciclovir