title: Regulation of keratinocyte function by growth factors.
abstract: Various kinds of growth factors are involved in the regulation of human keratinocyte function. Among them, the epidermal growth factor (EGF) family and the transforming growth factor-beta (TGF-beta) family play central roles, providing dual-mode regulation of keratinocyte growth through the proliferation-stimulating effect of EGF and the proliferation-inhibiting effect of TGF-beta. Human keratinocytes synthesize four EGF family growth factors, TGF-alpha, amphiregulin, HB-EGF and epiregulin, which efficiently regulate keratinocyte growth and differentiation via auto- and cross-induction pathways. Human keratinocytes also synthesize TGF-beta1 and TGF-beta2, which are potent inhibitors of human keratinocytes. These intrinsic EGF family growth factors and TGF-betas are responsible for the autonomous growth regulation of keratinocytes.
authors.affiliation: Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, 791-0295, Ehime, Japan. hashi@m.ehime-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
mesh_terms: D000818:Animals; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D015603:Keratinocytes / Q000502:physiology*; D012879:Skin Physiological Phenomena
chemical_list: D006133:Growth Substances