[Changes of hepatic energy metabolism following partial hepatopetal blood occlusion].
OBJECTIVE
To evaluate the changes of hepatic energy metabolism by temporary occlusion of partial hepatopetal blood.


METHODS
The animal mode of partial hepatopetal blood occlusion (PBO) was established without portal stasis. The hepatic energy metabolism parameters including adenosine triphosphate, respiratory control ratio, P/O ratio, and arterial ketone bodies ratio were studied following 30 min ischemia or 1, 6, and 24 h of reperfusion. The total hepatopetal blood occlusion (TBO) and sham groups served as control.


RESULTS
The parameters of hepatic motochondrial function reflecting hepatic damage to ischemia-reperfusion showed different in PBO comparing with TBO group. The functional lesion was restored progressively in PBO-30 min group, but it was maintained low level in TBO-30 min group.


CONCLUSIONS
The results suggest that it is beneficial to restoration of the hepatic energy metabolism in the ischemia-reperfusion injury by partial hepatopetal blood occlusion.
He
X
X
Department of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
Dong
J
J
Cai
J
J
Li
K
K
Duan
H
H
Han
B
B
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D004734:Energy Metabolism; D005260:Female; D007511:Ischemia / Q000378:metabolism*; D007657:Ketone Bodies / Q000378:metabolism; D008099:Liver / Q000098:blood supply / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism*
D007657:Ketone Bodies; D000255:Adenosine Triphosphate