title: Doppler evaluation of intrathyroid arterial resistances during preoperative treatment with Lugol's iodide solution in patients with diffuse toxic goiter.
abstract: BACKGROUND
  The aim of this study was to ascertain the utility of echo-Doppler in the analysis of the low resistance thyroid vascularization in diffuse toxic goiter (DTG), and the effectiveness of Lugol's solution (iodine-iodide solution) in patients undergoing thyroidectomy.
  
  
  METHODS
  Twenty-five patients with diffuse toxic goiter were evaluated and compared with 19 normal subjects. Patients were treated with increasing doses of Lugol's solution 2% for 7 days until a total dose of 75 mg of iodine was given. Echo-Doppler was performed on the last day of treatment, 12 hours before operation.
  
  
  RESULTS
  Mean basal Doppler Resistance Index (RI) of intrathyroid arterial flow was significantly lower in patients with DTG compared with normal controls (0.4718 +/- 0.0625 versus 0.55 +/- 0.05, range: 0.472 to 0.643; p = 0.008). Moreover, the RI was significantly increased in patients with DTG after Lugol's solution (+16.46 +/- 10.22%, range: -2.59 to +39.97; p< 0.0005).
  
  
  CONCLUSIONS
  Echo-Doppler RI allowed documenting lower arterial resistances within the thyroid gland in patients with DTG. The use of preoperative Lugol's solution therapy induces normalization of those changes for safer thyroidectomy.
authors.affiliation: Dipartimento di Discipline Chirurgiche, Morfologiche e Metodologie Integrate, Cattedra di Chirurgia Generale, Università degli Studi di Genova, Italy.
authors.forename: G L
authors.initials: GL
authors.lastname: Ansaldo
authors.forename: F
authors.initials: F
authors.lastname: Pretolesi
authors.forename: E
authors.initials: E
authors.lastname: Varaldo
authors.forename: C
authors.initials: C
authors.lastname: Meola
authors.forename: M
authors.initials: M
authors.lastname: Minuto
authors.forename: G
authors.initials: G
authors.lastname: Borgonovo
authors.forename: L E
authors.initials: LE
authors.lastname: Derchi
authors.forename: G C
authors.initials: GC
authors.lastname: Torre
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D001158:Arteries / Q000187:drug effects* / Q000503:physiopathology*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000628:therapy; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D007454:Iodides / Q000627:therapeutic use*; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000098:blood supply*; D013965:Thyroidectomy / Q000009:adverse effects; D018608:Ultrasonography, Doppler / Q000379:methods* / Q000592:standards; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D013956:Antithyroid Agents; D006490:Hemostatics; D007454:Iodides; D008713:Methimazole; C010389:Lugol's solution