Individual use of antibiotics and prevalence of beta-lactamase production among bacterial pathogens from middle ear fluid.
Prescription data and clinical laboratory data were analysed to assess the influence of previous antibiotic therapy on the prevalence of beta-lactamase in isolates of Haemophilus influenzae and Moraxella catarrhalis from primary specimens of middle ear fluid from 2129 children aged 0-5 years. The prevalence of beta-lactamase-positive H. influenzae was 6.6% [95% confidence interval (CI): 3.5-9.8%] in children who received antibiotics 5-90 days before isolation of the organism compared with 7.0% (95% CI: 3.9-10.2%) in those who did not. The prevalence of beta-lactamase-positive M. catarrhalis was 90.9% (95% CI: 84.0-97.8%) in children who received antibiotics compared with 86.7% (95% CI: 79.0-94.4%) in those who did not.
Thrane
N
N
The Danish Epidemiology Science Centre, Department of Epidemiology and Social Medicine, University of Aarhus, Aarhus C. Denmark. nthrane@dadlnet.dk
Olesen
C
C
Sørensen
H T
HT
Schønheyder
H C
HC
D000367:Age Factors; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006192:Haemophilus Infections / Q000453:epidemiology / Q000382:microbiology*; D006193:Haemophilus influenzae / Q000201:enzymology*; D006801:Humans; D007223:Infant; D008297:Male; D001936:Moraxella catarrhalis / Q000201:enzymology*; D016870:Neisseriaceae Infections / Q000453:epidemiology / Q000382:microbiology*; D010034:Otitis Media with Effusion / Q000453:epidemiology / Q000382:microbiology*; D012737:Sex Factors; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases