[Experimental aortic aneurysm].
Experimental aortic aneurysm may be evoked in animals by application of chemical compounds disturbing biosynthesis, posttranslating modifications and degradation of elastin and collagen, local damage of the aortic wall by chemical, thermal and mechanical factors and by increased blood pressure. Administration of protease inhibitors, anti-inflammatory drugs, agents enhancing synthesis and formation of elastic and collagen fibers and hypotensive drugs prevent formation enlargement and rupture of aneurysm.
Gacko
M
M
Klinika Chirurgii Naczyń i Transplantacji Akademii Medycznej w Białymstoku.
D017542:Aneurysm, Ruptured / Q000517:prevention & control; D000818:Animals; D001014:Aortic Aneurysm / Q000139:chemically induced* / Q000188:drug therapy*; D003094:Collagen / Q000187:drug effects / Q000378:metabolism; D004195:Disease Models, Animal; D004549:Elastin / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D011392:Proline / Q000187:drug effects / Q000378:metabolism
D003094:Collagen; D004549:Elastin; D011392:Proline