title: The commercial production of chemicals using pathway engineering.
abstract: Integration of metabolic pathway engineering and fermentation production technologies is necessary for the successful commercial production of chemicals. The 'toolbox' to do pathway engineering is ever expanding to enable mining of biodiversity, to maximize productivity, enhance carbon efficiency, improve product purity, expand product lines, and broaden markets. Functional genomics, proteomics, fluxomics, and physiomics are complementary to pathway engineering, and their successful applications are bound to multiply product turnover per cell, channel carbon efficiently, shrink the size of factories (i.e., reduce steel in the ground), and minimize product development cycle times to bring products to market.
authors.affiliation: Genencor International, 925 Page Mill Road, 94304, Palo Alto, CA, USA.
authors.forename: G
authors.initials: G
authors.lastname: Chotani
authors.forename: T
authors.initials: T
authors.lastname: Dodge
authors.forename: A
authors.initials: A
authors.lastname: Hsu
authors.forename: M
authors.initials: M
authors.lastname: Kumar
authors.forename: R
authors.initials: R
authors.lastname: LaDuca
authors.forename: D
authors.initials: D
authors.lastname: Trimbur
authors.forename: W
authors.initials: W
authors.lastname: Weyler
authors.forename: K
authors.initials: K
authors.lastname: Sanford
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis; D001205:Ascorbic Acid / Q000138:chemical synthesis; D002264:Carboxylic Acids / Q000191:economics; D002617:Chemical Industry; D003132:Commerce / Q000191:economics*; D005285:Fermentation; D023281:Genomics / Q000191:economics; D005947:Glucose / Q000378:metabolism; D006841:Hydrocarbons, Aromatic / Q000191:economics; D008956:Models, Chemical; D009930:Organic Chemicals / Q000138:chemical synthesis / Q000191:economics*; D015202:Protein Engineering / Q000191:economics*; D013400:Sugar Acids / Q000138:chemical synthesis
chemical_list: D000438:Alcohols; D002264:Carboxylic Acids; D006841:Hydrocarbons, Aromatic; D009930:Organic Chemicals; D013400:Sugar Acids; C011491:provitamin C; D005947:Glucose; D001205:Ascorbic Acid