title: Clinical and spectroscopic improvement in HIV-associated cognitive impairment.
abstract: To assess the impact of highly active antiretroviral therapy (HAART) on AIDS-associated cognitive impairment, 22 patients with AIDS with (n = 11) and without (n = 11) cognitive deficit were evaluated clinically and by MRS every 3 months for 9 months. Nineteen patients were on HAART at study entry, 21 after 2 months. Cognitively impaired patients presented with a subcorticofrontal deficit and decreased N-acetyl-aspartate in frontal white matter. These clinical and metabolic abnormalities reversed partially on HAART, whereas they remained within normal limits in cognitively unimpaired patients.
authors.affiliation: Fédération de Neurologie I, Hôpital Pitié Salpêtrière, and University Paris VI, France.
authors.forename: B
authors.initials: B
authors.lastname: Stankoff
authors.forename: A
authors.initials: A
authors.lastname: Tourbah
authors.forename: S
authors.initials: S
authors.lastname: Suarez
authors.forename: E
authors.initials: E
authors.lastname: Turell
authors.forename: J L
authors.initials: JL
authors.lastname: Stievenart
authors.forename: C
authors.initials: C
authors.lastname: Payan
authors.forename: A
authors.initials: A
authors.lastname: Coutellier
authors.forename: S
authors.initials: S
authors.lastname: Herson
authors.forename: L
authors.initials: L
authors.lastname: Baril
authors.forename: F
authors.initials: F
authors.lastname: Bricaire
authors.forename: V
authors.initials: V
authors.lastname: Calvez
authors.forename: E A
authors.initials: EA
authors.lastname: Cabanis
authors.forename: L
authors.initials: L
authors.lastname: Lacomblez
authors.forename: C
authors.initials: C
authors.lastname: Lubetzki
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000188:drug therapy*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D016896:Treatment Outcome