title: [Immunity against diphtheria and tetanus in the adult Polish population].
abstract: The aim of the study was to evaluate immunity against diphtheria and tetanus in healthy adult population in Poland. For determination of antitoxin IgG antibody, toxoid enzyme-linked immunosorbent assay (Toxoid-ELISA) was used. Serum samples were obtained from different regions of Poland and titrated for diphtheria (n = 2442) and tetanus (n = 827) IgG antitoxin. For calibration of anti-toxins determination, the WHO standard of human diphtheria and tetanus antitoxin was used. About 32% (n = 787) of persons were non-protected against diphtheria (IgG-DTAb < 0.1 IU/ml) and 24% (n = 195) against tetanus (IgG-TTAb < 0.1 IU/ml). In 63% (n = 1528) individuals basic protection for diphtheria and 48% (n = 402) for tetanus (0.1-1.0 IU/ml IgG-DTAb and IgG-TTAb) were observed. Only 5% (n = 127) were fully protected for diphtheria and 28% (n = 230) for tetanus (IgG-DTAb and IgG-TTAb > 1.0 IU/ml). In adults between 30-64 years of age, not vaccinated at least during last 10 years, 43% of persons were non-protected. The study showed insufficient immunity against diphtheria in adults. We indicate booster immunisation for selected group of persons.
authors.affiliation: Centralnego Laboratorium Surowic i Szczepionek Zakładu Immunologii i Profilaktyki Zakazeń.
authors.forename: J
authors.initials: J
authors.lastname: Walory
authors.forename: P
authors.initials: P
authors.lastname: Grzesiowski
authors.forename: W
authors.initials: W
authors.lastname: Hryniewicz
mesh_terms: D000328:Adult; D000368:Aged; D004165:Diphtheria / Q000276:immunology* / Q000517:prevention & control*; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012016:Reference Values; D016036:Seroepidemiologic Studies; D013742:Tetanus / Q000276:immunology* / Q000517:prevention & control*; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology
chemical_list: D004168:Diphtheria Toxoid; D007074:Immunoglobulin G; D013745:Tetanus Toxoid