title: Synthesis and biological activity of BIS-1,2,4-triazole and BIS-1,3,4-thiadiazole derivatives.
abstract: Synthesis of some new 1,2,4-triazole and 1,3,4-thiadiazole derivatives via the condensation of N'-substituted amidrazones and p-phenylenediisothiocyanate (PPD) is presented. The reaction conditions are discussed. Results of a preliminary pharmacological screening are presented.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medicine University, 6 Staszica Str., 20-081 Lublin, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Modzelewska-Banachiewicz
authors.forename: E
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
authors.forename: E
authors.initials: E
authors.lastname: Tokarzewska-Wielosz
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000700:Analgesics; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D013844:Thiazoles; D014230:Triazoles