title: Genomic exploration of the hemiascomycetous yeasts: 19. Ascomycetes-specific genes.
abstract: Comparisons of the 6213 predicted Saccharomyces cerevisiae open reading frame (ORF) products with sequences from organisms of other biological phyla differentiate genes commonly conserved in evolution from 'maverick' genes which have no homologue in phyla other than the Ascomycetes. We show that a majority of the 'maverick' genes have homologues among other yeast species and thus define a set of 1892 genes that, from sequence comparisons, appear 'Ascomycetes-specific'. We estimate, retrospectively, that the S. cerevisiae genome contains 5651 actual protein-coding genes, 50 of which were identified for the first time in this work, and that the present public databases contain 612 predicted ORFs that are not real genes. Interestingly, the sequences of the 'Ascomycetes-specific' genes tend to diverge more rapidly in evolution than that of other genes. Half of the 'Ascomycetes-specific' genes are functionally characterized in S. cerevisiae, and a few functional categories are over-represented in them.
authors.affiliation: Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université P. et M. Curie, Institut Pasteur, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Malpertuy
authors.forename: F
authors.initials: F
authors.lastname: Tekaia
authors.forename: S
authors.initials: S
authors.lastname: Casarégola
authors.forename: M
authors.initials: M
authors.lastname: Aigle
authors.forename: F
authors.initials: F
authors.lastname: Artiguenave
authors.forename: G
authors.initials: G
authors.lastname: Blandin
authors.forename: M
authors.initials: M
authors.lastname: Bolotin-Fukuhara
authors.forename: E
authors.initials: E
authors.lastname: Bon
authors.forename: P
authors.initials: P
authors.lastname: Brottier
authors.forename: J
authors.initials: J
authors.lastname: de Montigny
authors.forename: P
authors.initials: P
authors.lastname: Durrens
authors.forename: C
authors.initials: C
authors.lastname: Gaillardin
authors.forename: A
authors.initials: A
authors.lastname: Lépingle
authors.forename: B
authors.initials: B
authors.lastname: Llorente
authors.forename: C
authors.initials: C
authors.lastname: Neuvéglise
authors.forename: O
authors.initials: O
authors.lastname: Ozier-Kalogeropoulos
authors.forename: S
authors.initials: S
authors.lastname: Potier
authors.forename: W
authors.initials: W
authors.lastname: Saurin
authors.forename: C
authors.initials: C
authors.lastname: Toffano-Nioche
authors.forename: M
authors.initials: M
authors.lastname: Wésolowski-Louvel
authors.forename: P
authors.initials: P
authors.lastname: Wincker
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
authors.forename: J
authors.initials: J
authors.lastname: Souciet
authors.forename: B
authors.initials: B
authors.lastname: Dujon
mesh_terms: D001203:Ascomycota / Q000235:genetics*; D001483:Base Sequence; D017124:Conserved Sequence; D019143:Evolution, Molecular; D005800:Genes, Fungal; D014644:Genetic Variation; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013045:Species Specificity