title: Reversible renal failure in paroxysmal nocturnal hemoglobinuria.
abstract: A Chinese patient with paroxysmal nocturnal hemoglobinuria (PNH) developed acute nonoliguric renal failure with intercurrent urinary tract infection and hemolysis. There was no evidence of renal vein thrombosis. Renal biopsy showed features of acute tubular necrosis (ATN) and hemosiderosis. Magnetic resonance imaging (MRI) showed characteristic features of renal hemosiderosis. The patient was stabilized with temporary hemodialysis and intravenous fluid. The renal function fully recovered 3 weeks later. We review the literature and summarize the clinical features of this disease entity. To our knowledge, this case is the first to report such disorder with thorough investigation including concomitant diagnostic MRI imaging and renal biopsy.
authors.affiliation: Departments of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China.
authors.forename: K M
authors.initials: KM
authors.lastname: Chow
authors.forename: F M
authors.initials: FM
authors.lastname: Lai
authors.forename: A Y
authors.initials: AY
authors.lastname: Wang
authors.forename: Y L
authors.initials: YL
authors.lastname: Chan
authors.forename: N L
authors.initials: NL
authors.lastname: Tang
authors.forename: P K
authors.initials: PK
authors.lastname: Li
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D003404:Creatinine / Q000097:blood; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009336:Necrosis; D014552:Urinary Tract Infections / Q000209:etiology
chemical_list: D003404:Creatinine