title: VibD and VibH are required for late steps in vibriobactin biosynthesis in Vibrio cholerae.
abstract: Vibrio cholerae synthesizes the catechol siderophore vibriobactin. In this report, we present the complete map of a vibriobactin gene region containing two previously unreported vibriobactin biosynthetic genes. vibD encodes a phosphopantetheinyl transferase, and vibH encodes a novel nonribosomal peptide synthase. Both VibD and VibH are required for vibriobactin biosynthesis.
authors.affiliation: Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, University of Texas, Austin, Texas 78712-1095.
authors.forename: E E
authors.initials: EE
authors.lastname: Wyckoff
authors.forename: S L
authors.initials: SL
authors.lastname: Smith
authors.forename: S M
authors.initials: SM
authors.lastname: Payne
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002396:Catechols / Q000737:chemistry / Q000378:metabolism*; D004758:Enterobactin / Q000378:metabolism; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D005810:Multigene Family; D010080:Oxazoles; D010453:Peptide Synthases / Q000235:genetics* / Q000378:metabolism; D010957:Plasmids; D017855:Transferases (Other Substituted Phosphate Groups) / Q000235:genetics* / Q000378:metabolism; D014734:Vibrio cholerae / Q000201:enzymology* / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D002396:Catechols; D010080:Oxazoles; D004758:Enterobactin; C040227:vibriobactin; D017855:Transferases (Other Substituted Phosphate Groups); C021364:holo-(acyl-carrier-protein) synthase; D010453:Peptide Synthases