Peroxisome proliferator-activated receptors: roles in tumorigenesis and chemoprevention in human cancer.
Peroxisome proliferator-activated receptors are nuclear receptors that were isolated for their ability to modulate lipid metabolism. Similar to other members of the nuclear receptor family, peroxisome proliferator-activated receptors bind ligand as heterodimers and exert their effects via transcriptional regulation through their DNA binding domains. During the past decade, it has become clear that peroxisome proliferator-activated receptors also contribute to a variety of different biologic processes, including atherosclerosis, insulin resistance, and more recently, cancer. In this review, we discuss the evidence for the different peroxisome proliferator-activated receptors' roles in tumorigenesis and also their potential application for the treatment and prevention of neoplastic diseases.
Park
B H
BH
Molecular Genetics Laboratory, Johns Hopkins Oncology Center, Baltimore, Maryland, USA.
Breyer
B
B
He
T C
TC
D011125:Adenomatous Polyposis Coli / Q000503:physiopathology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001665:Binding Sites / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D018890:Chemoprevention; D006801:Humans; D008024:Ligands; D020025:Peroxisome Proliferators / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008024:Ligands; D020025:Peroxisome Proliferators