Expression levels of insulin-like growth factor binding proteins and insulin receptor isoforms in hepatoblastomas.
Hepatoblastoma, a rare pediatric liver tumour, is a poorly understood disease. While expression studies for some members of the Insulin-like growth factor axis have been studied in hepatoblastoma, a systematic analysis of the IGF-axis has not been carried out. We have examined a series of hepatoblastomas with matched normal liver tissue for gene expression differences with emphasis on members of the insulin-like growth factor binding proteins. The expression profiles obtained reveal that the expression of these genes are altered in these tumors. The results indicate that the IGF-axis is seriously disturbed in the tumors.
von Horn
H
H
Laboratory for Molecular Development and Tumor Biology, Experimental Alcohol and Drug Addiction Research Section, Department of Clinical Neuroscience, Karolinska Institute, CMM, L8 01, S-171 76, Stockholm, Sweden.
Tally
M
M
Hall
K
K
Eriksson
T
T
Ekström
T J
TJ
Gray
S G
SG
D000293:Adolescent; D000328:Adult; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006023:Glycoproteins / Q000096:biosynthesis / Q000235:genetics; D018197:Hepatoblastoma / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D011972:Receptor, Insulin / Q000096:biosynthesis* / Q000235:genetics; D012260:Ribonucleases / Q000378:metabolism
D002352:Carrier Proteins; D006023:Glycoproteins; D018969:Insulin-Like Growth Factor Binding Proteins; D020033:Protein Isoforms; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C075944:insulin-like growth factor binding protein, acid labile subunit; D011972:Receptor, Insulin; D012260:Ribonucleases