Allogeneic bone marrow transplantation-related transmission of human T lymphotropic virus type I (HTLV-I).
We report here the first case report of bone marrow transplantation (BMT)-related transmission of human T lymphotropic virus type-I (HTLV-I). Antibodies against HTLV-I-associated antigens (anti-HTLV-I) were detected in the serum from the BMT recipient 12 days post BMT. IgG against gag core proteins (anti-p19 and anti-p24) appeared earlier than IgM against gag and env proteins (anti-p19, anti-p24 and anti-gp46) during seroconversion. The data presented here differs from blood transfusion-related seroconversion. This phenomenon may be due to the engraftment of anti-HTLV-I producing cells from the donor.
Kikuchi
H
H
Second Department of Internal Medicine, Oita Medical University, Hasama-Oita, Japan.
Ohtsuka
E
E
Ono
K
K
Nakayama
T
T
Saburi
Y
Y
Tezono
K
K
Ogata
M
M
Iwahashi
M
M
Nasu
M
M
D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002353:Carrier State / Q000821:virology; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000276:immunology / Q000635:transmission*; D015368:Human T-lymphotropic virus 1; D006801:Humans; D019520:Living Donors; D008297:Male
D015481:HTLV-I Antibodies