title: Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum.
abstract: Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.
authors.affiliation: Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland. cavanagh@srv0@bio.ed.ac.uk
authors.forename: D R
authors.initials: DR
authors.lastname: Cavanagh
authors.forename: C
authors.initials: C
authors.lastname: Dobaño
authors.forename: I M
authors.initials: IM
authors.lastname: Elhassan
authors.forename: K
authors.initials: K
authors.lastname: Marsh
authors.forename: A
authors.initials: A
authors.lastname: Elhassan
authors.forename: L
authors.initials: L
authors.lastname: Hviid
authors.forename: E A
authors.initials: EA
authors.lastname: Khalil
authors.forename: T G
authors.initials: TG
authors.lastname: Theander
authors.forename: D E
authors.initials: DE
authors.lastname: Arnot
authors.forename: J S
authors.initials: JS
authors.lastname: McBride
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000145:classification*; D007223:Infant; D020066:Merozoite Surface Protein 1 / Q000276:immunology*; D008875:Middle Aged; D010446:Peptide Fragments / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D020066:Merozoite Surface Protein 1; D010446:Peptide Fragments