Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant.
Interleukin-2 (IL-2)/IL-15 receptor beta (IL-15R beta)(-/-) mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2(-/-) mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2(-/-) but not in IL-2/IL-15R beta(-/-) mice infected with Salmonella, suggesting that IL-2/IL-15R beta signaling is important for the generation of protective Th1 cells.
Nishimura
H
H
Laboratory of Host Defense & Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan. nishihit@med.nagoya-u.ac.jp
Tagaya
M
M
Tsunobuchi
H
H
Suzuki
H
H
Nakashima
I
I
Yoshikai
Y
Y
D000818:Animals; D004198:Disease Susceptibility; D007371:Interferon-gamma / Q000096:biosynthesis; D018664:Interleukin-12 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2 / Q000502:physiology*; D012481:Salmonella Infections, Animal / Q000276:immunology*; D019779:Salmonella enterica; D018417:Th1 Cells / Q000276:immunology
C508025:Il15ra protein, mouse; D007376:Interleukin-2; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2; D018664:Interleukin-12; D007371:Interferon-gamma