Diverse CD1d-restricted T cells: diverse phenotypes, and diverse functions.
Invariant CD1d-restricted T cells express NK cell markers and use a limited TCR repertoire. Here, we describe a second CD1d-restricted T cell subset that uses a diverse TCR repertoire. These T cells can also express NK cell markers and function similarly to invariant T cells. The antigens recognized by the diverse subset are likely to be different from those recognized by invariant TCRs. The variable NK1.1 antigen expression on these T cell populations limits its usefulness in identifying CD1d-restricted T cells. Lastly, the discovery of antigens recognized by diverse CD1d-restricted T cells will provide insight into their role in normal and pathological immune responses.
Behar
S M
SM
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Smith Building-Room 518, One Jimmy Fund Way, Boston, MA 02115, USA. sbehar@rics.bwh.harvard.edu
Cardell
S
S
D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D055610:Antigens, CD1d; D015415:Biomarkers; D006801:Humans; D016130:Immunophenotyping; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism*
D018949:Antigens, CD1; D055610:Antigens, CD1d; D015415:Biomarkers; C526877:CD1D protein, human