Elimination of S100B and renal function after cardiac surgery.
OBJECTIVE
To determine the biologic half-life of the S100B protein and to investigate if the elimination of S100B depends on glomerular filtration rate (GFR).


METHODS
Prospective human study.


METHODS
University hospital.


METHODS
Sixteen patients who underwent cardiac surgery with cardiopulmonary bypass.


METHODS
Shed mediastinal blood (autotransfusion) was returned to the patients postoperatively and used to study the kinetics of S100B. Iohexol was infused simultaneously to estimate GFR. S100B was measured at 0, 20, 40, 60, and 180 minutes after infusion. Iohexol was measured at 180 and 240 minutes after infusion.


RESULTS
S100B followed first-order kinetics, and the biologic half-life for S100B was determined to be 25.3 +/- 5.1 minutes. GFR was determined to be 63.8 +/- 34.4 mL/min. No correlation was found between GFR and S100B half-life.


CONCLUSIONS
The elimination of S100B after cardiac surgery is faster than reported earlier and not affected by a moderate decrease in GFR. This finding is important when evaluating S100B levels after cardiac surgery.
Jönsson
H
H
Department of Cardiothoracic Surgery, University Hospital, Lund, Sweden.
Johnsson
P
P
Höglund
P
P
Alling
C
C
Blomquist
S
S
D000368:Aged; D015415:Biomarkers; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007677:Kidney Function Tests; D008297:Male; D009414:Nerve Growth Factors; D011184:Postoperative Period; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood / Q000378:metabolism* / Q000652:urine
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human