Differential changes in islet amyloid polypeptide (amylin) and insulin mRNA expression after high-fat diet-induced insulin resistance in C57BL/6J mice.
Islet amyloid, derived from islet amyloid polypeptide (IAPP or amylin), frequently occurs in type 2 diabetes. Availability of this peptide for amyloid formation may be enhanced by increased islet expression of IAPP. In the insulin resistant state, euglycemia is maintained by hypersecretion of insulin. Whether
Mulder
H
H
Department of Physiological Sciences, Lund University, Sweden.
Mårtensson
H
H
Sundler
F
F
Ahrén
B
B
D000682:Amyloid / Q000235:genetics*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage* / Q000494:pharmacology; D005947:Glucose / Q000502:physiology; D005951:Glucose Tolerance Test; D017403:In Situ Hybridization; D007328:Insulin / Q000235:genetics*; D007333:Insulin Resistance / Q000502:physiology*; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D012333:RNA, Messenger / Q000378:metabolism*
D000682:Amyloid; D004041:Dietary Fats; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D012333:RNA, Messenger; D005947:Glucose