Amyloid beta vaccination: reduced plaques and improved cognition.
Studies in three different transgenic mouse models suggest that the amyloid beta-protein contributes to memory loss in Alzheimer disease. Immunization with an amyloid beta-peptide fragment reduces learning and memory impairments in mice, and this approach may eventually be used to prevent and/or treat this disease in people.
Younkin
S G
SG
Center for Neuroscience, Mayo Clinic Jacksonville, Jacksonville, Florida, USA. younkin.steven@mayo.edu
D000544:Alzheimer Disease / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000818:Animals; D003072:Cognition Disorders / Q000628:therapy*; D004195:Disease Models, Animal; D051379:Mice; D008822:Mice, Transgenic; D016874:Neurofibrillary Tangles; D014612:Vaccines / Q000008:administration & dosage*
D016229:Amyloid beta-Peptides; D014612:Vaccines