Concurrent secretion of aldosterone and cortisol from an adrenal adenoma - value of MRI in diagnosis.
A 43-year-old female with a 24-years history of hypertension presented for further investigation and management of primary hyperaldosternoism. Postural studies were not conclusive and magnetic resonance (MR) imaging demonstrated a 27 x 18 mm lesion of the right adrenal gland which showed no signal loss during in and out of phase imaging. Although these appearances were considered to be atypical of those seen on MR in patients with aldosterone producing adrenal adenomas the patient underwent an adrenalectomy with removal of a 3 x 3 x 2 cm right adrenal mass. Post-operatively she became hypotensive and a 0900 hours serum cortisol was undetectable (< 50 nmol/l), consistent with adrenal insufficiency. Following the administration of hydrocortisone there was normalization of the blood pressure and subsequent adrenal stimulation tests confirmed the presence of functioning adrenal tissue albeit with an inadequate response. Cortisol measurement from preoperative samples revealed loss of normal diurnal rhythm whereas DHEAS levels both pre and postoperatively were undetectable, consistent with ACTH supression resulting from autonomous cortisol secretion in addition to aldosterone. Concurrent secretion of cortisol should always be considered in Conn's adenomas particularly when atypical radiological features are present.
Allan
C A
CA
Department of Endocrinology, St Bartholomew's Hospital, London, UK.
Kaltsas
G
G
Perry
L
L
Lowe
D G
DG
Reznek
R
R
Carmichael
D
D
Monson
J P
JP
D000236:Adenoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D003366:Cosyntropin; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009363:Neoplasm Proteins / Q000378:metabolism
D009363:Neoplasm Proteins; D003366:Cosyntropin; D000450:Aldosterone; D006854:Hydrocortisone