title: Influenza A in a basic training population: implications for directly observed therapy.
abstract: OBJECTIVE
  To describe our evaluation of basic trainees exposed to influenza A and our experience with mass prophylaxis.
  
  
  METHODS
  Using a structured interview, 101 individuals were evaluated for symptoms of influenza A. Nasopharyngeal wash specimens were obtained from symptomatic troops; amantadine prophylaxis was prescribed for all. Diagnosis was confirmed using a rapid influenza assay or shell vial culture. After completing prophylaxis, the group was reevaluated to determine medication compliance and perceived side effects.
  
  
  RESULTS
  At baseline, 80 trainees reported symptoms. Three additional cases of influenza were identified, two using the rapid assay. Reported compliance with amantadine prophylaxis was 46.5%.
  
  
  CONCLUSIONS
  Nonspecific complaints that could be consistent with viral infection were numerous in this basic trainee cohort. The rapid assay allowed us to expediently identify additional patients, who were then removed from the cohort to limit further transmission. Compliance with prophylaxis was poor; thus, directly observed therapy is recommended.
authors.affiliation: Department of Infectious Diseases, Wilford Hall Medical Center, San Antonio, TX 78236, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Rowles
authors.forename: E A
authors.initials: EA
authors.lastname: Walter
authors.forename: D M
authors.initials: DM
authors.lastname: Dolan
authors.forename: L C
authors.initials: LC
authors.lastname: Canas
authors.forename: P A
authors.initials: PA
authors.lastname: Meier
mesh_terms: D000337:Aerospace Medicine / Q000379:methods; D000547:Amantadine / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D009980:Influenza A virus; D007251:Influenza, Human / Q000150:complications / Q000175:diagnosis* / Q000517:prevention & control*; D007318:Inservice Training; D008403:Mass Screening / Q000379:methods; D008887:Military Medicine / Q000379:methods; D008889:Military Personnel / Q000523:psychology*; D017817:Nasal Lavage Fluid / Q000821:virology; D010349:Patient Compliance / Q000523:psychology*; D011795:Surveys and Questionnaires; D013781:Texas
chemical_list: D000998:Antiviral Agents; D000547:Amantadine