Vancomycin-resistant Enterococcus faecium strain carrying the vanB2 gene variant in a Polish hospital.
About 2.5 years after the first isolation of the VanA phenotype of vancomycin-resistant Enterococcus faecium (VREM) in Poland, the first VREM strains with the VanB phenotype have emerged independently in two different Warsaw hospitals. In one of these the VREM strain was selected during the long-term antimicrobial treatment of a patient with a wide variety of infection risk factors who died after 3 months of hospitalization. The strain was found to contain the transferable vanB2 gene cluster variant of the polymorphic type that was identified earlier in vancomycin-resistant enterococci from several different countries. In the course of infection the strain underwent genetic diversification due to DNA recombination.
Kawalec
M
M
Sera & Vaccines Central Research Laboratory, 00-725 Warsaw, Poland.
Gniadkowski
M
M
Zielińska
U
U
Kłos
W
W
Hryniewicz
W
W
D000208:Acute Disease; D000368:Aged; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins / Q000235:genetics*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D016984:Enterococcus faecium / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D017809:Fatal Outcome; D005260:Female; D014644:Genetic Variation; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis*; D006801:Humans; D008826:Microbial Sensitivity Tests; D005810:Multigene Family; D009102:Multiple Organ Failure; D009336:Necrosis; D010195:Pancreatitis / Q000473:pathology / Q000601:surgery; D011044:Poland; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C079913:VanB protein, Enterococcus