Neural stem cells are uniquely suited for cell replacement and gene therapy in the CNS.
In recent years, it has become evident that the developing and even the adult mammalian CNS contain a population of undifferentiated, multipotent cell precursors, neural stem cells, the plastic properties of which might be of advantage for the design of more effective therapies for many neurological diseases. This article reviews the recent progress in establishing rodent and human clonal neural stem cell lines, their biological properties, and how these cells can be utilized to correct a variety of defects, with prospects for the near future to harness their behaviour for neural stem cell-based treatment of diseases in humans.
Ourednik
V
V
Departments of Neurology (Division of Neuroscience), Pediatrics (Division of Newborn Medicine), & Neurosurgery, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Ourednik
J
J
Park
K I
KI
Teng
Y D
YD
Aboody
K A
KA
Auguste
K I
KI
Taylor
R M
RM
Tate
B A
BA
Snyder
E Y
EY
D000328:Adult; D000818:Animals; D002460:Cell Line; D002490:Central Nervous System / Q000601:surgery*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000601:surgery* / Q000628:therapy*; D009474:Neurons / Q000637:transplantation*; D033581:Stem Cell Transplantation