title: Mechanisms that prevent and produce double ovulations in dairy cattle.
abstract: This review integrates information on follicular and hormonal physiology and epidemiology into a novel physiological model for regulation of the ovulation rate in lactating dairy cows. First, the basic mechanisms that produce a single ovulation are examined. Follicular deviation is a critical new concept in our understanding of selection of a single dominant follicle. Follicular deviation is characterized by an abrupt deviation in the growth rates between the two largest follicles when the future dominant follicle reaches a diameter of 8.5+/-1.2 mm (mean and SD). The mechanisms involved in this selection process are not completely defined but appear to involve acquisition of LH receptors on granulosa cells of the dominant follicle, increased estradiol production by the dominant follicle, and inhibition of circulating FSH concentrations. Second, lactation number and milk production were found to be critical epidemiological factors associated with increased ovulation rate and twinning in dairy cattle. Finally, high steroid metabolism is proposed as the critical link between high milk production and double ovulation. It is proposed that high milk production increases steroid metabolism due to increased blood flow to the digestive tract and subsequently to the liver. The liver represents the primary site of steroid metabolism, and blood entering the liver is cleared of steroids. At the time of selection of the dominant follicle, the normal increase in circulating estradiol concentrations and subsequent depression in circulating FSH is blunted due to estradiol metabolism. Thus, FSH remains elevated for a time sufficient to allow follicles to undergo the physiological changes necessary to proceed to ovulation.
authors.affiliation: Endocrinology-Reproductive Physiology Program, and Department of Dairy Science, University of Wisconsin-Madison, 53706, USA. wiltbank@calship.cals.wisc.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Wiltbank
authors.forename: P M
authors.initials: PM
authors.lastname: Fricke
authors.forename: S
authors.initials: S
authors.lastname: Sangsritavong
authors.forename: R
authors.initials: R
authors.lastname: Sartori
authors.forename: O J
authors.initials: OJ
authors.lastname: Ginther
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000037:antagonists & inhibitors / Q000097:blood; D006107:Granulosa Cells / Q000502:physiology*; D007700:Kinetics; D007774:Lactation; D008954:Models, Biological; D006080:Ovarian Follicle / Q000254:growth & development / Q000502:physiology*; D010060:Ovulation / Q000502:physiology*; D010298:Parity; D011673:Pulsatile Flow; D011974:Receptors, LH; D013256:Steroids / Q000378:metabolism*; D013997:Time Factors; D014427:Twins
chemical_list: D011974:Receptors, LH; D013256:Steroids; D004958:Estradiol; D005640:Follicle Stimulating Hormone