Gene therapy for vein graft disease.
Applying gene therapeutics to vein graft disease requires foundational knowledge of the underlying pathophysiology. This review details a brief description of vein graft disease, examines published and unpublished data on gene transfer to veins, and reviews the genes, which have significantly altered vascular biology.
Cable
D G
DG
Division of Cardiovascular Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. cable.david@mayo.edu
Schaff
H V
HV
D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology; D017930:Genes, Reporter; D015316:Genetic Therapy; D006083:Graft Occlusion, Vascular / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006965:Hyperplasia; D017539:Tunica Intima / Q000473:pathology