Synthesis and activity of selective MMP inhibitors with an aryl backbone.
A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.
Barta
T E
TE
Pharmacia, Department of Medicinal Chemistry, Skokie, IL 60077, USA. barta@netmug.org
Becker
D P
DP
Bedell
L J
LJ
De Crescenzo
G A
GA
McDonald
J J
JJ
Munie
G E
GE
Rao
S
S
Shieh
H S
HS
Stegeman
R
R
Stevens
A M
AM
Villamil
C I
CI
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D017364:Collagenases / Q000737:chemistry / Q000378:metabolism; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D020781:Matrix Metalloproteinase 1 / Q000737:chemistry / Q000378:metabolism; D053509:Matrix Metalloproteinase 13; D020778:Matrix Metalloproteinase 2 / Q000737:chemistry / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D017364:Collagenases; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13; D020778:Matrix Metalloproteinase 2; D020781:Matrix Metalloproteinase 1