title: [A combination phase I/II study--dose escalation plan].
abstract: There are no guidelines for dose escalation methods of combination chemotherapy. Thus, in order to evaluate this method, we selected 30 reports on two drug combination chemotherapies without support by BMT, that were published in the Journal of Clinical Oncology from 1997 to 1999. The present report describes the starting dose, patient number at each dose level, or dose escalation method in these 30 papers.
authors.affiliation: Dept. of Internal Medicine IV, Kinki University School of Medicine, 377-2 Ohno-higashi, Oosaka-Sayama 589-8511, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamamoto
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D017321:Clinical Trials, Phase I as Topic / Q000379:methods*; D017322:Clinical Trials, Phase II as Topic / Q000379:methods*; D004334:Drug Administration Schedule; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D012107:Research Design
chemical_list: D000970:Antineoplastic Agents