title: Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes.
abstract: In the search for new marker genes suitable to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture, we have identified and characterized a novel gene called chondrocyte expressed protein-68 (CEP-68), harbouring an N-terminal leader peptide and an epidermal growth factor-like calcium-binding domain. CEP-68 defines a new family of proteins and complements collagen type II as a new marker for stem-cell-based chondrogenic tissue engineering.
authors.affiliation: Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Steck
authors.forename: K
authors.initials: K
authors.lastname: Benz
authors.forename: H
authors.initials: H
authors.lastname: Lorenz
authors.forename: M
authors.initials: M
authors.lastname: Loew
authors.forename: T
authors.initials: T
authors.lastname: Gress
authors.forename: W
authors.initials: W
authors.lastname: Richter
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D002478:Cells, Cultured; D019902:Chondrocytes / Q000378:metabolism*; D018076:DNA, Complementary / Q000032:analysis; D015870:Gene Expression; D005819:Genetic Markers; D006801:Humans; D008969:Molecular Sequence Data; D010006:Osteoblasts / Q000378:metabolism; D010641:Phenotype; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C422245:CRTAC1 protein, human; D002135:Calcium-Binding Proteins; D018076:DNA, Complementary; D005819:Genetic Markers