title: Residential pesticide exposure and neuroblastoma.
abstract: Neuroblastoma is the most common neoplasm in children under 1 year of age. We examined the relation between residential exposure to pesticides and neuroblastoma, using data from a case-control study of risk factors for neuroblastoma. Incident cases of neuroblastoma (N = 538) were identified through the Pediatric Oncology Group and the Children's Cancer Group. One age-matched control was identified for each case by random digit dialing. Telephone interviews with each parent collected information on residential exposure to pesticides. Pesticide use in both the home and garden were modestly associated with neuroblastoma [odds ratio (OR) = 1.6 (95% confidence interval [95% CI] = 1.0-2.3, and OR = 1.7 (95% CI = 0.9-2.1), respectively]. Compared with infants [OR = 1.0 (95% CI = 0.6-2.0)], stronger associations were found for garden pesticides in children diagnosed after 1 year of age [OR = 2.2 (95% CI = 1.3-3.6)], which suggests that pesticides may act through a mechanism more common for neuroblastomas in older children. There was no evidence of differential pesticide effects in subgroups of neuroblastoma defined by MYCN oncogene amplification or tumor stage.
authors.affiliation: Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Daniels
authors.forename: A F
authors.initials: AF
authors.lastname: Olshan
authors.forename: K
authors.initials: K
authors.lastname: Teschke
authors.forename: I
authors.initials: I
authors.lastname: Hertz-Picciotto
authors.forename: D A
authors.initials: DA
authors.lastname: Savitz
authors.forename: J
authors.initials: J
authors.lastname: Blatt
authors.forename: M L
authors.initials: ML
authors.lastname: Bondy
authors.forename: J P
authors.initials: JP
authors.lastname: Neglia
authors.forename: B H
authors.initials: BH
authors.lastname: Pollock
authors.forename: S L
authors.initials: SL
authors.lastname: Cohn
authors.forename: A T
authors.initials: AT
authors.lastname: Look
authors.forename: R C
authors.initials: RC
authors.lastname: Seeger
authors.forename: R P
authors.initials: RP
authors.lastname: Castleberry
mesh_terms: D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D002675:Child, Preschool; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D009447:Neuroblastoma / Q000139:chemically induced* / Q000453:epidemiology; D016017:Odds Ratio; D010575:Pesticides / Q000009:adverse effects*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D010575:Pesticides