title: Transcriptional regulation of RANTES expression in T lymphocytes.
abstract: We first identified the RANTES chemokine as part of a search for genes expressed by T lymphocytes "late", 3-5 days, after T-cell activation. The kinetics of expression of RANTES and a small number of other genes are unusual and the mechanism of such delayed expression is unknown. In order to uncover a mechanism for such "late" expression, we identified and characterized the RANTES promoter and a novel transcription factor regulating RANTES expression in T lymphocytes. RANTES factor of late activated T lymphocytes (RFLAT)-1 is a member of the Krüppel-like family of transcription factors. Like RANTES, RFLAT-1 expression is "late" after T-cell activation. But, unlike RANTES, regulation of RFLAT-1 expression appears to be translational rather than transcriptional.
authors.affiliation: Department of Pediatrics, Stanford University, California 94305-5164, USA.
authors.forename: A
authors.initials: A
authors.lastname: Song
authors.forename: T
authors.initials: T
authors.lastname: Nikolcheva
authors.forename: A M
authors.initials: AM
authors.lastname: Krensky
mesh_terms: D000818:Animals; D018946:Chemokine CCL5 / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D014158:Transcription, Genetic; D015533:Transcriptional Activation / Q000276:immunology*
chemical_list: D018946:Chemokine CCL5