title: Use of danaparoid sodium (Orgaran) as an alternative to heparin sodium during cardiopulmonary bypass: a clinical evaluation of six cases.
abstract: Heparin-induced thrombocytopenia (HIT) has become more prevalent in today's cardiac setting and has resulted in the need for alternative anticoagulant therapies. Danaparoid sodium, one alternative to heparin, has been used in six cardiopulmonary bypass procedures in this hospital. This clinical experience has resulted in the progressive refinement of a protocol for the 'safe' clinical use of danaparoid sodium. Although there were six positive outcomes with the use of danaparoid sodium, alternatives must be explored in order to find the optimal anticoagulant for the treatment of HIT.
authors.affiliation: Clinical Perfusion Services, London Health Sciences Centre, Ontario, Canada. philip.fernandes@lhsc.on.ca
authors.forename: P
authors.initials: P
authors.lastname: Fernandes
authors.forename: R
authors.initials: R
authors.lastname: Mayer
authors.forename: J L
authors.initials: JL
authors.lastname: MacDonald
authors.forename: A G
authors.initials: AG
authors.lastname: Cleland
authors.forename: C
authors.initials: C
authors.lastname: Hay-McKay
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000592:standards; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D002809:Chondroitin Sulfates / Q000008:administration & dosage* / Q000009:adverse effects / Q000592:standards; D003871:Dermatan Sulfate / Q000008:administration & dosage* / Q000009:adverse effects / Q000592:standards; D004338:Drug Combinations; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000009:adverse effects; D006497:Heparan Sulfate / Q000008:administration & dosage* / Q000009:adverse effects / Q000592:standards; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D004338:Drug Combinations; D006493:Heparin; D006497:Heparan Sulfate; C035838:danaparoid