[Mutational analysis of p53 in T-cell lymphoblastic leukemia].
BACKGROUND
p53 mutations were analysed in a consecutive series of patients with T-ALL from one hospital over a period of 9 years.


METHODS
Thirty two samples from 27 patients with T-ALL were included in the study. Exons 5-9 were analysed using SSCP.


RESULTS
A mutation at codon 273 was identified in a child in third relapse. The mutated clone became dominant in a sample obtained one month following a course of salvage chemotherapy.


CONCLUSIONS
p53 mutations are not frequent in T-ALL even in patients at relapse.
Nomdedéu
J F
JF
Hematología. Hospital de la Santa Creu i Sant Pau. Barcelona. jnomdedeu@santpau.es
Badell
I
I
Estivill
C
C
del Río
E
E
Sierra
J
J
Baiget
M
M
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D012189:Retrospective Studies; D013997:Time Factors