Development of model aqueous ophthalmic solution of indomethacin.
A new model aqueous solution of indomethacin was developed on the basis of Pluronic F68 (15%) and F127 (10%). They showed some practical advantages over the models prepared with polyols and polysorbate 80, which were used for comparison. It was found that both Pluronics acted very similarly and were more effective as solubilizers, created an appropriate viscosity, and formed reversible gels at higher temperatures, ensured the indomethacin chemical stability and prolonged in vitro drug diffusion, and showed high physiological tolerance on rabbit eyes. Moreover, indomethacin stability and solution viscosity in the presence of Pluronics did not change after heat sterilization (i.e., the samples can bear heat sterilization).
Dimitrova
E
E
Faculty of Pharmacy, Medical University, Sofia, Bulgaria.
Bogdanova
S
S
Mitcheva
M
M
Tanev
I
I
Minkov
E
E
D005079:Excipients / Q000008:administration & dosage; D006358:Hot Temperature; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D020442:Poloxamer / Q000008:administration & dosage; D013242:Sterilization
D005079:Excipients; D009883:Ophthalmic Solutions; D020442:Poloxamer; D007213:Indomethacin