Polycystic ovary disease and the risk of pregnancy-induced hypertension.
OBJECTIVE
To compare the incidence of pregnancy-induced hypertension in patients with and without polycystic ovary disease (PCOD).


METHODS
We conducted a retrospective, case-control analysis of patients who achieved singleton pregnancies with human menopausal gonadotropin (hMG) therapy. Twenty-two PCOD patients were compared to 27 infertility patients without PCOD who were pregnant after hMG therapy. Non-PCOD patients received hMG for superovulation as part of superovulation/intrauterine insemination or in vitro fertilization/embryo transfer. PCOD patients were receiving hMG for simple ovulation induction. Pregnancy-induced hypertension was defined as late pregnancy blood pressure > 140/90 mm Hg on two readings six hours apart and return to normal blood pressure by four to six weeks postpartum.


RESULTS
There were no differences between PCOD and non-PCOD patients with reference to age, body mass index, parity or other pregnancy-induced hypertension risk factors (i.e., chronic hypertension, diabetes or chronic renal disease). Pregnant PCOD patients had a much higher incidence of pregnancy-induced hypertension, 31.8% (7/22), versus non-PCOD patients, who only had a pregnancy-induced hypertension incidence of 3.7% (1/27) (P = .016, OR = 12.1, 95% CI = 1.3-566.8).


CONCLUSIONS
PCOD patients are at very high risk of pregnancy-induced hypertension when pregnant after ovulation induction.
Kashyap
S
S
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.
Claman
P
P
D016022:Case-Control Studies; D005260:Female; D006801:Humans; D015994:Incidence; D009864:Ontario / Q000453:epidemiology; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology*; D011247:Pregnancy; D012189:Retrospective Studies