title: Comparison of strength properties of poly-L/D-lactide (PLDLA) 96/4 and polyglyconate (Maxon) sutures: in vitro, in the subcutis, and in the achilles tendon of rabbits.
abstract: Achilles tendon rupture is a common injury. Absorbable sutures are not commonly used because of their limited strength properties. Recently, sutures with prolonged strength retention properties have been developed. The aim of the study is to test the mechanical properties of recently developed poly-L/D-lactide (PLDLA) sutures in comparison with polyglyconate (Maxon) sutures. PLDLA (0.2 mm thick) and Maxon (4.0) sutures were studied in vitro by immersion in a buffered saline solution (pH 7.4). Tensile strength tests were done on sutures retrieved after 1-26 weeks. In vivo, they were implanted in the subcutis of 32 rabbits. Tensile strength tests were done on sutures retrieved after 1-6 weeks. The sutures were also used to repair the Achilles tendon in rabbits. Maximum force before breaking and percentage elongation of tendons were determined. Although PLDLA had a lower initial tensile strength than Maxon, PLDLA showed more prolonged tensile strength retention than Maxon. Tendons repaired with PLDLA, however, had a lower strength than Maxon-repaired tendons at six weeks (insignificant difference). PLDLA has more prolonged tensile strength properties compared with Maxon. Thus, PLDLA offers an alternative to Maxon in repair of the Achilles tendon.
authors.affiliation: Department of Surgery, Oulu University Hospital, Oulu, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kangas
authors.forename: S
authors.initials: S
authors.lastname: Paasimaa
authors.forename: P
authors.initials: P
authors.lastname: Mäkelä
authors.forename: J
authors.initials: J
authors.lastname: Leppilahti
authors.forename: P
authors.initials: P
authors.lastname: Törmälä
authors.forename: T
authors.initials: T
authors.lastname: Waris
authors.forename: N
authors.initials: N
authors.lastname: Ashammakhi
mesh_terms: D020341:Absorbable Implants; D000125:Achilles Tendon / Q000293:injuries / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D062109:Dermatologic Surgical Procedures; D008422:Materials Testing; D009928:Organ Specificity; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D012421:Rupture / Q000601:surgery; D013536:Suture Techniques; D013537:Sutures; D013718:Tensile Strength; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; C033616:poly(lactide); C046409:polyglyconate