Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus.
Acute nicotine administration (0.5 mg/kg i.p.) significantly decreased BDNF mRNA levels in dentate gyrus, CA3 and CA1 subfields of the rat hippocampus 2 h and 24 h after administration. However, with 7 days nicotine treatment, tolerance developed to the inhibitory effect of nicotine on BDNF mRNA expression and there was a significant increase in BDNF expression 2 h after the final injection in the CA1 region. These data suggests that changes in expression of hippocampal BDNF may be involved in the behavioural effects of nicotine observed after acute and chronic treatment.
Kenny
P J
PJ
Psychopharmacology Research Unit, Centre for Neuroscience Research, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Hospital Campus, London SE1 1UL, UK.
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Rattray
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D000109:Acetylcholine / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002908:Chronic Disease; D018891:Dentate Gyrus / Q000187:drug effects* / Q000502:physiology*; D015870:Gene Expression / Q000187:drug effects / Q000502:physiology; D017403:In Situ Hybridization; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology; D014029:Tobacco Use Disorder / Q000503:physiopathology
D019208:Brain-Derived Neurotrophic Factor; D018722:Nicotinic Agonists; D012333:RNA, Messenger; D009538:Nicotine; D000109:Acetylcholine