title: Routine serologic testing for hepatitis C virus infection should be instituted among dialysis patients.
abstract: Since the cloning of hepatitis C virus (HCV), a number of serologic and virologic tests for detecting infections with this virus have been made available for clinical practice. This led to the recognition of HCV as a major health hazard in hemodialysis (HD) centers. Yet the nephrology community has not been offered explicit recommendations about routine serologic testing for HCV of dialysis patients and consequently has remained unclear and divided about the utility of this testing. This review presents evidence in support of instituting routine serologic testing for HCV among dialysis patients. It concludes that because of the peculiar features of HCV infection in HD patients, serologic testing for HCV is the only means for unequivocal diagnosis of hepatitis C and an irreplaceable instrument for monitoring the incidence and the prevalence of the infection in this population. Serologic surveillance for HCV infection is crucial for identifying the association of new cases of HCV infection with potential risk factors for HCV transmission, particularly nosocomial, that can be modified in a way to prevent further dissemination of the virus. Data collected from routine serologic testing for HCV will undoubtedly improve our understanding of the epidemiology of HCV in the dialysis population and will provide a strong foundation for developing preventive measures and infection control strategies that are highly effective in controlling HCV infection. Routine serologic testing for HCV is also of direct benefit to the individual patient since establishing the HCV serologic status of each patient is important for optimizing patient care.
authors.affiliation: Division of Nephrology, New England Medical Center, Boston, Massachusetts 02111, USA.
authors.forename: S N
authors.initials: SN
authors.lastname: Natov
authors.forename: B J
authors.initials: BJ
authors.lastname: Pereira
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000914:Antibodies, Viral / Q000302:isolation & purification; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D012367:RNA, Viral / Q000302:isolation & purification; D006435:Renal Dialysis
chemical_list: D000914:Antibodies, Viral; D012367:RNA, Viral; D000410:Alanine Transaminase