title: Antihistamines.
abstract: In the 1990s, major improvements occurred in the therapeutic index of H1 antihistamines. The third-generation compounds promise to be more effective and nontoxic. The future major advances are likely to result from development and exploitation of non-H1 receptor-mediated antiallergic actions of these drugs.
authors.affiliation: St. John's Institute of Dermatology, St. Thomas' Hospital, London, United Kingdom.
authors.forename: M W
authors.initials: MW
authors.lastname: Greaves
mesh_terms: D002908:Chronic Disease; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000503:physiopathology; D006632:Histamine / Q000502:physiology; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008415:Mastocytosis / Q000188:drug therapy / Q000503:physiopathology; D014581:Urticaria / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D006634:Histamine H1 Antagonists; D006632:Histamine