title: Are quantitative functional measures more sensitive to worsening MS than traditional measures?
abstract: The authors used data collected prospectively during a multicenter trial in 133 patients with secondary progressive MS to assess the relative sensitivity of quantitative functional tests and traditional measures, including the Expanded Disability Status Scale (EDSS) and Ambulation Index. Quantitative functional measures worsened in 69% of patients during an average of 6 months of observation, whereas the Clinical Global Impression of Change worsened in 33% and the EDSS worsened in 25% of patients. These changes should be interpreted in the context of the test-retest reliability for each measure.
authors.affiliation: Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Schwid
authors.forename: A D
authors.initials: AD
authors.lastname: Goodman
authors.forename: B R
authors.initials: BR
authors.lastname: Apatoff
authors.forename: P K
authors.initials: PK
authors.lastname: Coyle
authors.forename: L D
authors.initials: LD
authors.lastname: Jacobs
authors.forename: L B
authors.initials: LB
authors.lastname: Krupp
authors.forename: A E
authors.initials: AE
authors.lastname: Miller
authors.forename: K E
authors.initials: KE
authors.lastname: Wende
authors.forename: C M
authors.initials: CM
authors.lastname: Brownscheidle
authors.lastname: New York State Multiple Sclero
mesh_terms: D006801:Humans; D009103:Multiple Sclerosis / Q000503:physiopathology*; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity