Radiofrequency induction heating for the treatment of aortic dissection in an animal model.
BACKGROUND
In this study, radiofrequency (RF) induction heating therapy using a self-expanding Gianturco metallic stent (G-EMS) to treat acute aortic dissection was evaluated.


METHODS
We evaluated convergent RF induction heating of G-EMS in pigs. In group A (n=3), an aortic dissection was created to determine the natural course of this lesion. In group B (n=4), 0.40 mm stainless steel bare G-EMSs (2.5 cm, 10 bends) were placed in the aorta 5 to 7 days after dissection, and RF induction heating was performed for 30 (n=2) or 45 (n=2) minutes. In group C (n=6), G-EMSs with 0.10 mm ferro-chrome wire mounted on alternating stent legs were placed in the aorta 1 to 7 days after dissection, and RF induction heating was performed for 10 minutes.


RESULTS
In group A, 2 pigs died from rupture of the false lumen. In group B, fusion of the dissection flap was confirmed histologically. However, all of the pigs died. In group C, all of the pigs tolerated the procedure, and fusion of the dissection flap was confirmed in all of the pigs.


CONCLUSIONS
This experimental animal study suggested that RF induction heating combined with G-EMS, if properly applied, has a potential to treat acute aortic dissection.
Fujii
H
H
Department of Thoracic and Cardiovascular Surgery, Kansai Medical University, Moriguchi, Osaka, Japan.
Sawada
S
S
Tanigawa
N
N
Ito
E
E
Imamura
H
H
D000784:Aortic Dissection / Q000628:therapy*; D000818:Animals; D017545:Aortic Aneurysm, Thoracic / Q000628:therapy*; D004195:Disease Models, Animal; D006979:Hyperthermia, Induced / Q000379:methods; D011474:Prosthesis Design; D015607:Stents; D013552:Swine