Expression of Ki-67 in cervical epithelial cells in preneoplastic lesions of patients with AIDS.
The objective of the present investigation was to study the expression of the proliferation marker Ki-67 in cervical intraepithelial lesions in women with AIDS. We studied 18 low-grade cervical intraepithelial lesions (Lo-CIN) and 8 high-grade cervical intraepithelial lesions (Hi-CIN ) in AIDS patients and 18 Lo-CIN and 14 Hi-CIN in patients from the general population. Positive Ki-67 nuclei were counted. A significantly higher number of Ki-67-positive cells (p < 0.001) was found in Lo-CIN of AIDS patients (mean 29.18 +/- 10.44) as compared with Lo-CIN of general-population women (mean 17.08 +/- 7.40), whereas no significant difference in positive Ki-67 nuclei was observed in the Hi-CIN of AIDS patients and of patients from the general population (p > 0.05). We conclude that the proliferative potential of cervical cells in Lo-CIN - as studied by the expression of the proliferation marker Ki-67 - is higher in AIDS patients than in the general population.
Calore
E E
EE
Emílio Ribas Infectology Institute, Pathology Section, São Paulo, Brazil. calore@sti.com.br
Cavaliere
M J
MJ
Perez Calore NM
de Souza Dias S
Paes Dos Santos R
Vilela-De-Almeida
L
L
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000293:Adolescent; D000328:Adult; D002467:Cell Nucleus / Q000737:chemistry; D002584:Cervix Uteri / Q000737:chemistry* / Q000648:ultrastructure; D004847:Epithelial Cells / Q000737:chemistry / Q000648:ultrastructure; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis*; D012189:Retrospective Studies; D002578:Uterine Cervical Dysplasia / Q000737:chemistry* / Q000150:complications
D019394:Ki-67 Antigen