Repair of corticospinal axons by transplantation of olfactory ensheathing cells.
This paper examines the possibility of repairing cut central connections by transplantation of glial cells which modify the glial pathways and take advantage of the inherent growth capacity in adult neurons. We found that transplants of cultured olfactory ensheathing cells into lesions of the adult rat corticospinal tract induced long growth of cut axons across the lesion. Acquisition of a directed forepaw reaching function was restored on the operated side.
Raisman
G
G
Division of Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
D000818:Animals; D001369:Axons / Q000502:physiology*; D016380:Brain Tissue Transplantation / Q000379:methods*; D009457:Neuroglia / Q000637:transplantation*; D009833:Olfactory Pathways / Q000166:cytology*; D011712:Pyramidal Tracts / Q000166:cytology / Q000601:surgery*; D012583:Schwann Cells / Q000166:cytology