Synthesis and biological evaluation of analogues of bacterial lipid I.
Bacterial Lipid I analogues containing different anomeric groups at the muramic acid moiety were synthesized and screened in MurG enzyme assays run in the presence and absence of cell wall membranes. The results obtained in this study help elucidate the role of the lipid diphosphate in the recognition of Lipid I by MurG.
Silva
D J
DJ
Department of Chemistry, Incara Research Laboratories, Cranbury, NJ 08536, USA. domingos_j_silva@sbphrd.com
Bowe
C L
CL
Branstrom
A A
AA
Baizman
E R
ER
Sofia
M J
MJ
D001419:Bacteria / Q000737:chemistry / Q000201:enzymology / Q000648:ultrastructure; D001425:Bacterial Outer Membrane Proteins / Q000037:antagonists & inhibitors*; D002462:Cell Membrane / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006017:Glycolipids / Q000138:chemical synthesis* / Q000494:pharmacology*; D008969:Molecular Sequence Data; D009112:Muramic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D017351:N-Acetylglucosaminyltransferases / Q000037:antagonists & inhibitors; D010457:Peptidoglycan; D011103:Polyisoprenyl Phosphate Monosaccharides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D001425:Bacterial Outer Membrane Proteins; D004791:Enzyme Inhibitors; D006017:Glycolipids; D009112:Muramic Acids; D010457:Peptidoglycan; D011103:Polyisoprenyl Phosphate Monosaccharides; C062771:undecaprenyl biphosphate-N-acetylmuramoyl-pentapeptide; D017351:N-Acetylglucosaminyltransferases; C064057:UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase