title: ACE and alpha-adducin genotypes and renal disease progression.
abstract: In the REIN study of non-diabetic proteinuric nephropathies, renal disease progression was independent of the angiotensin-converting enzyme (ACE) and alpha-adducin genotypes. However, the ACE genotype predicted the renoprotective effect of ACE inhibition. Subgroup analysis in patients with Berger disease showed a tendency (NS) for a faster progression in DD homozygotes.
authors.affiliation: CNR Centro Fisiologia Clinica e Unità Operativa di Nefrologia, Dialisi e Trapianto Renale, Reggio Calabria, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Zoccali
mesh_terms: D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D018450:Disease Progression; D005838:Genotype; D006801:Humans; D007674:Kidney Diseases / Q000235:genetics / Q000503:physiopathology*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000502:physiology; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D007703:Peptidyl-Dipeptidase A; D000099291:Adducins