Dynamics of peroxisome assembly and function.
Recent studies in human cells and in the yeast Yarrowia lipolytica have shown that peroxisomes consist of numerous structurally distinct subcompartments that differ in their import competency for various proteins and are related through a time-ordered conversion of one subcompartment to another. Our studies have implicated the fusion of small peroxisomal precursors as an early event in the multistep assembly of peroxisomes operating in Y. lipolytica. Newly discovered unexpected roles for peroxisomes in specific developmental programs have expanded the remarkable plasticity of peroxisomal functions. Here, we highlight recent discoveries on the highly dynamic nature of peroxisome assembly and function and suggest questions for future research in these areas.
Titorenko
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Dept of Cell Biology, University of Alberta, Edmonton, T6G 2H7, Alberta, Canada
Rachubinski
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D000818:Animals; D006801:Humans; D008561:Membrane Fusion; D020675:Peroxisomes / Q000502:physiology*; D021381:Protein Transport; D004718:Saccharomycetales / Q000502:physiology