title: Decline in the HIV-1 isolation rate in Japan: a 12-year observation.
abstract: Since 1988, we have isolated HIV-1 from 614 HIV-1-infected persons (total sample=2,785) in Japan. During the past 12 years, we have found a decline in the HIV-1 isolation rate in Japan, with two identifiable turning points, 1991-1992 and 1996-1997. The two turning points correspond to shifts in anti-HIV-1 therapy. These findings suggest that HIV-1 in Japan is currently biologically well controlled, probably due to anti-HIV-1 therapy. On the other hand, this decline is inconsistent with the recent increase of genetic drug-resistant HIV-1 in Japan. Further studies are needed to clarify mechanisms that might explain the discrepancy.
authors.affiliation: Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan. nakabone@nih.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Nakasone
authors.forename: J
authors.initials: J
authors.lastname: Takamatsu
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Naganawa
authors.forename: K
authors.initials: K
authors.lastname: Somey
authors.forename: N
authors.initials: N
authors.lastname: Yoshino
authors.forename: M
authors.initials: M
authors.lastname: Kaizu
authors.forename: T
authors.initials: T
authors.lastname: Ohsu
authors.forename: M
authors.initials: M
authors.lastname: Takizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Izumi
authors.forename: M
authors.initials: M
authors.lastname: Kawahara
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimura
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
authors.forename: S
authors.initials: S
authors.lastname: Yamazaki
authors.forename: M
authors.initials: M
authors.lastname: Honda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007564:Japan / Q000453:epidemiology; D007963:Leukocytes, Mononuclear / Q000821:virology; D008297:Male; D008875:Middle Aged; D014766:Viremia
chemical_list: D019380:Anti-HIV Agents