The sign of Leser-Trélat: a paraneoplastic cutaneous syndrome that facilitates early diagnosis of occult cancer.
The sign of Leser-Trélat has been described as a rare cutaneous marker of internal malignancy. We report a patient presenting with the sign of Leser-Trélat, in whom a limited diagnostic workup for an associated malignancy lead to the early diagnosis of asymptomatic renal cell carcinoma and curative tumor nephrectomy. A review on this and other cutaneous paraneoplastic syndromes is given. Since they may be the only presenting sign of an occult cancer, patients with these syndromes should undergo a diagnostic screening program for malignant disease.
Vielhauer
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Medizinische Poliklinik, Ludwig-Maximilians-Universität München, Pettenkoferstr 8a, D-80336 München, Germany. vielhaue@pk-i.med.uni-muenchen.de
Herzinger
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Korting
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HC
D000368:Aged; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D017492:Keratosis, Seborrheic / Q000473:pathology*; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology*; D012867:Skin / Q000473:pathology; D014057:Tomography, X-Ray Computed