[Acute cholestatic hepatitis induced by propylthiouracil. Case report].
Propylthiouracil is widely used to treat patients with hyperthyroidism. However, propylthiouracil-induced hepatitis is an uncommon entity. The case of a 15-year-old boy treated with propylthiouracil for hyperthyroidism who developed a cholestatic acute hepatitis is reported. Viral, metabolic and autoimmune liver diseases were excluded and liver biopsy showed a pattern suggestive of drug-induced cholestatic hepatitis. After discontinuing the drug, there was a progressive resolution of symptoms and normalization of liver biochemical tests. Despite its rarity, patients receiving propylthiouracil are exposed to develop severe hepatotoxicity.
Parolin
M B
MB
Serviço de Transplante Hepático e Serviço de Anatomia Patológica, Hospital de Clínicas da Universidade Federal do Paraná HC-UFPR.
Lopes
R W
RW
Telles
J E
JE
Ioshii
S O
SO
Hajar
N
N
D000208:Acute Disease; D000293:Adolescent; D013956:Antithyroid Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008111:Liver Function Tests; D008297:Male; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use
D013956:Antithyroid Agents; D011441:Propylthiouracil