Synthesis and antiviral activity of novel methylene cyclopropyl nucleosides.
Novel exomethylene cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5 was synthesized in 4 steps, from Feists acid 1 and was condensed with purine derivatives by the SN2 type reaction to give some cyclopropyl nucleosides. The synthesized nucleosides did not showed any significant antiviral activity against HSV-1, HSV-2, HCMV, HIV-1, HIV-2, and HBV up to 100 microM.
Kwak
E Y
EY
Department of Medicinal Chemistry, College of Pharmacy, Chonnam National University, Kwangju, Korea.
Hong
J H
JH
Lee
C K
CK
Choi
B G
BG
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D003521:Cyclopropanes; D009705:Nucleosides