title: Cost analysis of an adult outpatient parenteral antibiotic therapy (OPAT) programme. A Canadian teaching hospital and Ministry of Health perspective.
abstract: BACKGROUND
  Outpatient parenteral antibiotic therapy (OPAT) programmes have become prevalent over the past 2 decades. From the US perspective, these programmes have been shown to reduce healthcare costs. No comprehensive analysis has been published from the Canadian perspective.
  
  
  OBJECTIVE
  To describe a Canadian OPAT programme for the 3-year period since its inception and to conduct a treatment cost analysis.
  
  
  METHODS
  Demographics and resource utilisation data (health professional labour, laboratory and diagnostic tests, antimicrobials, delivery, home nursing care, catheters and catheter placement) were prospectively collected for enrollees in the OPAT programme over the evaluation period. Avoided hospital resource utilisation was estimated via retrospective chart review by the investigators. Costs were retrospectively assigned to each resource and total cost avoidance by the OPAT programme was determined from each perspective.
  
  
  CONCLUSIONS
  A teaching hospital and a provincial Ministry of Health (MOH).
  
  
  RESULTS
  140 treatment courses were initiated for 117 adult patients (mean age 54 years) who were enrolled into the programme. Mean pre-OPAT length of hospital stay was 12 days, and mean OPAT duration was 22.5 days. Bone/joint (39%), skin and soft tissue (16%), cardiac (13%) and respiratory tract (12%) infections were the most common infections managed. The most commonly used antimicrobials were vancomycin (29%), cloxacillin +/- gentamicin (22%) and ceftriaxone +/- gentamicin (11%) 85% of enrollees successfully completed their planned antimicrobial treatment regimens. Premature discontinuation of antimicrobial therapy for various reasons occurred in the remaining 15% of courses. The mean cost per treatment course of OPAT was 1910 Canadian dollars ($Can) from the hospital perspective and $Can6326 from the MOH perspective. Assuming that patients would have otherwise completed their antimicrobial therapy in hospital, the mean cost per treatment course was estimated to be $Can14,271. The overall cost avoidance of the OPAT programme was $Can1,730,520 (hospital perspective) and $Can1,009,450 (MOH perspective) over the 3-year assessment period. Sensitivity analyses revealed the results to be robust to plausible changes.
  
  
  CONCLUSIONS
  This analysis supports the premise that an adult OPAT programme can substantially reduce healthcare costs in the Canadian healthcare setting.
authors.affiliation: Vancouver Hospital and Health Sciences Centre and Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: A O
authors.initials: AO
authors.lastname: Wai
authors.forename: L
authors.initials: L
authors.lastname: Frighetto
authors.forename: C A
authors.initials: CA
authors.lastname: Marra
authors.forename: E
authors.initials: E
authors.lastname: Chan
authors.forename: P J
authors.initials: PJ
authors.lastname: Jewesson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care / Q000191:economics* / Q000379:methods; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000191:economics*; D002170:Canada; D006077:Government Agencies; D018718:Home Infusion Therapy / Q000191:economics*; D006784:Hospitals, Teaching; D006801:Humans; D007263:Infusions, Parenteral / Q000191:economics; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000900:Anti-Bacterial Agents