title: BRCA1 and cell signaling.
abstract: The breast cancer and ovarian cancer susceptibility gene BRCA1 encodes a nucleoprotein whose mutations or aberrant expression is associated with both inherited and sporadic cancers. Studies over the last 6 years have suggested that BRCA1 may function as a scaffold in the assembly of a multi-protein complex, which plays a role in gene transcription, DNA damage repair, and transcription-coupled DNA damage repair. In this review, we discuss the implications drawn from the studies of BRCA1-interacting proteins and the cellular signaling pathways that may be involved in controlling the functions of BRCA1.
authors.affiliation: Department of Pathology and Laboratory Medicine, The University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: R
authors.initials: R
authors.lastname: Fishel
authors.forename: M I
authors.initials: MI
authors.lastname: Greene
mesh_terms: D000818:Animals; D017209:Apoptosis; D019313:BRCA1 Protein / Q000502:physiology*; D002453:Cell Cycle; D020090:Chromosome Segregation; D004249:DNA Damage; D004260:DNA Repair; D005786:Gene Expression Regulation; D006801:Humans; D015398:Signal Transduction
chemical_list: D019313:BRCA1 Protein