Solution phase synthesis of libraries of variably substituted olefin scaffolds: a library of allylic amines.
The synthesis of allylic amine libraries derived from olefin templates is described. The two-step, solution phase reaction sequence consists of amination of the template followed by Suzuki coupling and expedited purification via ion exchange chromatography. The methodology has been used to synthesize a 1344-member allylic amine library.
Organ
M G
MG
Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada.
Mayhew
D
D
Cooper
J T
JT
Dixon
C E
CE
Lavorato
D J
DJ
Kaldor
S W
SW
Siegel
M G
MG
D000475:Alkenes / Q000737:chemistry*; D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002852:Chromatography, Ion Exchange; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
D000475:Alkenes; D000498:Allyl Compounds; D000588:Amines; D007202:Indicators and Reagents