title: Sequence diversity of a fragment of the 16S RNA gene from Helicobacter pylori.
abstract: Helicobacter pylori is one of the most common bacterial pathogens. It is the main cause of gastric and duodenal ulcers and has been associated with other diseases. The organism seems to be more genetically diverse than other bacterial pathogens, and the source of these differences awaits explanation. The sequence of a fragment of the 16S rRNA gene was determined for ten strains of H. pylori to examine the contribution of point mutation within a conserved gene. There were few differences between the sequences from the various strains and it was concluded that such differences were not the most important source of diversity.
authors.affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London, Great Britain.
authors.forename: M M
authors.initials: MM
authors.lastname: Khan
authors.forename: N G
authors.initials: NG
authors.lastname: Stoker
authors.forename: B S
authors.initials: BS
authors.lastname: Drasar
mesh_terms: D001483:Base Sequence; D017124:Conserved Sequence; D005798:Genes, Bacterial; D020459:Genes, rRNA; D014644:Genetic Variation; D016480:Helicobacter pylori / Q000235:genetics*; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D016415:Sequence Alignment
chemical_list: D012336:RNA, Ribosomal, 16S