title: Ab initio structure determinations by direct-space methods: tests of low-density elimination.
abstract: The low-density elimination method, which was developed for phase extension and refinement, has been investigated regarding its power to solve crystal structures starting from completely random phase sets. The method employs a multi-solution strategy. Low-symmetry structures are easily solvable where phase restrictions are only applied to a few reflections. Even with high-symmetry structures, a reasonable solution was obtained regarding centric reflections as general reflections. It is also shown that the structure of a small protein ribonuclease Ap1 is solvable if the positions of the five S atoms in the protein are known.
authors.affiliation: Faculty of Science, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Matsugaki
authors.forename: M
authors.initials: M
authors.lastname: Shiono
mesh_terms: D003461:Crystallography; D015394:Molecular Structure