title: [Importance of upper digestive endoscopy using lugol dye solution for the diagnosis of superficial esophageal cancer and dysplasia in patients with head and neck neoplasms].
abstract: Head and neck cancer has a high incidence in Brazil, with cancer of the oral cavity being one of the five most common cancers among Brazilians. Alcohol and tobacco consumption may contribute to synchronous or metachronous head and neck cancer and esophageal cancer. A prospective study involving 60 patients with head and neck cancer was carried out at the State University of Campinas--UNICAMP, Campinas, SP, Brazil to screen for superficial esophageal cancer and dysplasia using endoscopy and a 2% lugol dye solution followed by biopsy of the suspicious areas. Five patients (8.3%) had superficial esophageal cancer, which was diagnosed as intraepithelial carcinoma in three of them (5.0%). In four patients, the superficial esophageal cancer was synchronous and in one it was metachronous to head and neck cancer. Five patients (8.3%) had dysplasias in the esophageal epithelium (three were classified as mild and two as moderate). These results demonstrate the value of endoscopic screening of the esophagus using lugol dye in patients with head and neck cancer, particularly since superficial esophageal cancer is extremely difficult to detect by conventional methods in asymptomatic patients.
authors.affiliation: Disciplina de Cirurgia de Cabeça e Pescoço do Departamento de Cirurgia da Universidade Estadual de Campinas-UNICAMP, Campinas, SP. tincani@unicamp.br
authors.forename: A J
authors.initials: AJ
authors.lastname: Tincani
authors.forename: N
authors.initials: N
authors.lastname: Brandalise
authors.forename: N A
authors.initials: NA
authors.lastname: Andreollo
authors.forename: L R
authors.initials: LR
authors.lastname: Lopes
authors.forename: C G
authors.initials: CG
authors.lastname: Montes
authors.forename: A
authors.initials: A
authors.lastname: Altemani
authors.forename: A S
authors.initials: AS
authors.lastname: Martins
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D004396:Coloring Agents; D004935:Esophageal Diseases / Q000473:pathology; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D004945:Esophagoscopy / Q000379:methods*; D005260:Female; D006258:Head and Neck Neoplasms; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013194:Staining and Labeling
chemical_list: D004396:Coloring Agents