title: Extragonadal germ cell tumors: clinicopathologic findings, staging and treatment experience in 14 patients.
abstract: Extragonadal germ cell tumors (EGCT) are a rare group of neoplasms histologically identical to testicular counterparts. Fourteen cases of primary mediastinal and retroperitoneal germ cell tumors were treated with chemotherapy and radiotherapy between 1987 and 1999 in Ankara Oncology Hospital. There were 9 (64%) complete remissions (CR),one (7%) partial remission (PR) and 2 (14%) stable diseases (SD). The remaining 2 patients were lost due to dissemination of disease. The median duration of response was 19 months. Our modified chemotherapeutic results were similar to original doses of PVB and BEP but toxicity was less. The neccesity of a uniform staging system and treatment programs are discussed.
authors.affiliation: Dept. of Urologic Oncology and Radiotherapy, Ankara Oncology Education and Research Hospital, Turkey. defne@mail.koc.net
authors.forename: F
authors.initials: F
authors.lastname: Berkmen
authors.forename: A F
authors.initials: AF
authors.lastname: Peker
authors.forename: A
authors.initials: A
authors.lastname: Ayyildiz
authors.forename: S
authors.initials: S
authors.lastname: Başay
authors.forename: A I
authors.initials: AI
authors.lastname: Arik
authors.forename: I
authors.initials: I
authors.lastname: Uğur
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D018237:Germinoma / Q000097:blood / Q000473:pathology / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008479:Mediastinal Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D012074:Remission Induction; D012186:Retroperitoneal Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins