High throughput screening of gene expression signatures.
This paper focuses on microarray image analysis and discusses a completely automated approach to image processing, which eliminates human intervention. A system for automated image processing is described, which is capable of processing image files in a batch-mode thus allowing high-throughput of microarray image analysis. Grid-placement and spot finding are achieved without operator's help. The software eliminates noise signals from the data analysis process and minimizes operator's involvement in the procedure.
Kuklin
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BioDiscovery Inc., Los Angeles, CA 9006, USA. akuklin@biodiscovery.com
Shams
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S
Shah
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S
D000465:Algorithms; D001331:Automation / Q000295:instrumentation / Q000379:methods; D015870:Gene Expression; D005820:Genetic Testing / Q000295:instrumentation / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results