title: Successful pregnancy by transmyometrial and transtubal embryo transfer after IVF in a patient with congenital cervical atresia who underwent uterovaginal canalization during Caesarean section: case report.
abstract: Successful pregnancy in a patient with congenital cervical atresia is a great challenge for assisted reproductive techniques and reproductive medicine. We report a case of successful pregnancy by transmyometrial and transtubal embryo transfer simultaneously after in-vitro fertilization (IVF) in a 33 year-old patient with congenital cervical atresia diagnosed at the age of 18 years. The patient had experienced cyclic abdominal pain and amenorrhoea since she was 13 years old. She had had two unsuccessful attempts to create a new uterovaginal canal in another hospital. At the age of 32 years, she was referred to our unit and had a successful pregnancy after transmyometrial and transtubal embryo transfer. Caesarean section was performed at 36 weeks gestation due to progressive pre-eclampsia and gestational diabetes. A healthy male baby weighing 2812 g was safely delivered. Uterovaginal canalization with amniotic membrane for the covering of the neo-endocervical wall was performed during Caesarean section. Normal menstrual outflow and symptomatic relief have continued for 5 months after the operation. To the best of our knowledge, this is the first reported case of successful pregnancy by transmyometrial and transtubal embryo transfer as well as uterovaginal canalization performed during Caesarean section in a patient with congenital cervical atresia.
authors.affiliation: Department of Obstetrics and Gynecology, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan.
authors.forename: T H
authors.initials: TH
authors.lastname: Lai
authors.forename: M H
authors.initials: MH
authors.lastname: Wu
authors.forename: K H
authors.initials: KH
authors.lastname: Hung
authors.forename: Y C
authors.initials: YC
authors.lastname: Cheng
authors.forename: F M
authors.initials: FM
authors.lastname: Chang
mesh_terms: D000650:Amnion / Q000601:surgery; D002584:Cervix Uteri / Q000002:abnormalities* / Q000601:surgery*; D002585:Cesarean Section; D003251:Constriction, Pathologic; D004624:Embryo Transfer / Q000379:methods*; D005187:Fallopian Tubes; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009215:Myometrium; D011247:Pregnancy; D011256:Pregnancy Outcome; D014599:Uterus / Q000002:abnormalities / Q000601:surgery*; D014621:Vagina / Q000601:surgery