Effect of dofetilide on the pharmacokinetics of digoxin.
The effect of dofetilide on the steady-state pharmacokinetics of digoxin was evaluated in a randomized, double-blind study. Five days of dofetilide treatment did not significantly affect steady-state pharmacokinetic variables of digoxin compared with placebo; therefore, the use of dofetilide does not necessitate an adjustment in digoxin dose to maintain therapeutic digoxin levels.
Kleinermans
D
D
Pfizer Clinical Research Unit, H pital Erasme, Brussels, Belgium.
Nichols
D J
DJ
Dalrymple
I
I
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004077:Digoxin / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D008297:Male; D010627:Phenethylamines / Q000097:blood / Q000494:pharmacology*; D013449:Sulfonamides / Q000097:blood / Q000494:pharmacology*
D000889:Anti-Arrhythmia Agents; D010627:Phenethylamines; D013449:Sulfonamides; D004077:Digoxin; C063533:dofetilide