title: [A patient of infantile polymyositis triggered by respiratory syncytium virus infection].
abstract: An 11-month-old boy developed acute polymyositis about 1 week after respiratory syncytium virus (RSV) pneumonia. He was admitted to our hospital because of interstitial pneumonia. RSV infection was confirmed by the presence of its antigen in his nasal discharge. Two weeks later, his chest X-ray findings improved and RSV antigen became negative, but severe generalized muscle weakness developed, causing respiratory failure. Muscle biopsy demonstrated inflammatory cellular infiltration with occasional fiber necrosis. Intravenous steroid pulse therapy was remarkably effective resulting in complete recovery of his muscle power. In this patient polymyositis was preceded with RSV infection, suggesting a close relationship between polymyositis and RSV infection. Although many patients of viral myositis have been reported to be associated with coxsackie B, HCV and HTLV-1 viruses, our patient is the first infantile polymyositis secondary to RSV infection.
authors.affiliation: Department of Pediatrics, Tsuchiura Kyodo Hospital, Tsuchiura, Ibaraki.
authors.forename: T
authors.initials: T
authors.lastname: Nagasawa
authors.forename: H
authors.initials: H
authors.lastname: Sakuma
authors.forename: S
authors.initials: S
authors.lastname: Araki
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Makino
authors.forename: I
authors.initials: I
authors.lastname: Nonaka
mesh_terms: D000208:Acute Disease; D006801:Humans; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D011024:Pneumonia, Viral / Q000150:complications*; D017285:Polymyositis / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D012131:Respiratory Insufficiency / Q000209:etiology; D018357:Respiratory Syncytial Virus Infections / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D011239:Prednisolone; D008775:Methylprednisolone