Early neonatal brain injury in histologic chorioamnionitis.
The relation between clinical or histologic chorioamnionitis and early neonatal adverse neurologic outcome was investigated (n = 483). Histologic, but not clinical, evidence of chorioamnionitis was found to be a significant predictor of periventricular echodensity (odds ratio, 2.4; 95% CI, 1.8-3.2), echolucency (3.3; 1.9-5.6), ventriculomegaly (2.7; 1.8-4.2), intraventricular hemorrhage > or =3 (3.5; 2.4-5.2), and seizures (2.3; 1.4-3.7).
De Felice C
Department of Preventive Pediatrics and Neonatology, the Institute of Pathology, University of Siena, Siena, Italy.
Toti
P
P
Laurini
R N
RN
Stumpo
M
M
Picciolini
E
E
Todros
T
T
Tanganelli
P
P
Buonocore
G
G
Bracci
R
R
D000367:Age Factors; D001930:Brain Injuries / Q000000981:diagnostic imaging / Q000209:etiology*; D002552:Cerebral Ventricles / Q000293:injuries*; D002821:Chorioamnionitis / Q000150:complications* / Q000473:pathology*; D005260:Female; D006652:Histological Techniques / Q000592:standards*; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000000981:diagnostic imaging / Q000209:etiology*; D007969:Leukomalacia, Periventricular / Q000000981:diagnostic imaging / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D010920:Placenta / Q000473:pathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D012640:Seizures / Q000000981:diagnostic imaging / Q000209:etiology*; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D017585:Ultrasonography, Doppler, Transcranial