Mechanisms of changes in lymphocyte numbers after psychological stress.
In the field of psychoneuroimmunology it has become obvious that the immune system is governed by multiple influences from the central nervous system. One approach to verify these interactions can be seen in stress research. While the phenomenon of stress-induced changes in immunological processes is widely accepted, more recent studies focus on possible moderators and mechanisms of these responses. Within this research strategy it became evident that catecholamine increases upon stress are of major importance for the frequently observed mild leukocytosis. The present study was conducted to investigate whether the often observed stress-induced increases in the number of peripheral lymphocyte subsets depends on the amount of epinephrine or norepinephrine release. Moreover, the question was addressed whether high or low catecholamine release is related to subjective ratings on discomfort. Using a "public speaking paradigm", we were able to replicate previous findings of high increases in the absolute number of CD8+ and CD56+ cells in peripheral blood. Moreover, when dividing subjects into high and low catecholamine responders, the amount of change was significantly larger in catecholamine responders irrespective of whether norepinephrine or epinephrine was used for grouping the subjects. However, high and low catecholamine responders did not differ with respect to subjective ratings on discomfort. The data are discussed with respect to underlying mechanisms in catecholamine-induced lymphocyte migration and possible reasons for the mismatch between objective and subjective indicators of stressor efficacy.
Hennig
J
J
Center for Psychobiology and Behavioral Medicine, Department of Psychology, Justus-Liebig-University of Giessen, Otto-Behaghel-Str. 10, 35394 Giessen, Germany. juergen.hennig@psychol.uni-giessen.de
Netter
P
P
Voigt
K
K
D000328:Adult; D001143:Arousal / Q000502:physiology; D004837:Epinephrine / Q000097:blood*; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D013315:Stress, Psychological / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D009638:Norepinephrine; D004837:Epinephrine