title: Solution phase synthesis of libraries of variably substituted olefin scaffolds: a library of allylic amines.
abstract: The synthesis of allylic amine libraries derived from olefin templates is described. The two-step, solution phase reaction sequence consists of amination of the template followed by Suzuki coupling and expedited purification via ion exchange chromatography. The methodology has been used to synthesize a 1344-member allylic amine library.
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, M3J 1P3, Canada.
authors.forename: M G
authors.initials: MG
authors.lastname: Organ
authors.forename: D
authors.initials: D
authors.lastname: Mayhew
authors.forename: J T
authors.initials: JT
authors.lastname: Cooper
authors.forename: C E
authors.initials: CE
authors.lastname: Dixon
authors.forename: D J
authors.initials: DJ
authors.lastname: Lavorato
authors.forename: S W
authors.initials: SW
authors.lastname: Kaldor
authors.forename: M G
authors.initials: MG
authors.lastname: Siegel
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002852:Chromatography, Ion Exchange; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
chemical_list: D000475:Alkenes; D000498:Allyl Compounds; D000588:Amines; D007202:Indicators and Reagents