title: The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography.
abstract: OBJECTIVE
  The ability to make an early, accurate diagnosis of rheumatoid arthritis (RA) has become increasingly important with the availability of new, expensive, and targeted therapies. However, plain radiography, the traditional method of detecting the characteristic bone erosions and an important adjunct in establishing a diagnosis of RA, is known to be insensitive. This study compared sonography, a modern imaging technique, with conventional radiography for the detection of erosions in the metacarpophalangeal (MCP) joints of patients with RA.
  
  
  METHODS
  One hundred RA patients (including 40 with early disease) underwent posteroanterior radiography and sonography of the MCP joints of the dominant hand. Twenty asymptomatic control subjects also underwent sonography. Erosion sites were recorded and subsequently compared using each modality. Magnetic resonance imaging (MRI) was performed on the second MCP joint in 25 patients with early RA to confirm the pathologic specificity of sonographic erosions. Intraobserver reliability of sonography readings was assessed using video recordings of 55 MCP joint scans of RA patients, and interobserver reliability was assessed by comparing 160 MCP joint scans performed sequentially by 2 independent observers.
  
  
  RESULTS
  Sonography detected 127 definite erosions in 56 of 100 RA patients, compared with radiographic detection of 32 erosions (26 [81%] of which coincided with sonographic erosions) in 17 of 100 patients (P < 0.0001). In early disease, sonography detected 6.5-fold more erosions than did radiography, in 7.5-fold the number of patients. In late disease, these differences were 3.4-fold and 2.7-fold, respectively. On MRI, all sonographic erosions not visible on radiography (n = 12) corresponded by site to MRI abnormalities. The Cohen-kappa values for intra- and interobserver reliability of sonography were 0.75 and 0.76, respectively.
  
  
  CONCLUSIONS
  Sonography is a reliable technique that detects more erosions than radiography, especially in early RA. Sonographic erosions not seen on radiography corresponded to MRI bone abnormalities. This technology has potential in the management of patients with early RA/inflammatory arthritis and is likely to have major implications for the future practice of rheumatology.
authors.affiliation: University of Leeds, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Wakefield
authors.forename: W W
authors.initials: WW
authors.lastname: Gibbon
authors.forename: P G
authors.initials: PG
authors.lastname: Conaghan
authors.forename: P
authors.initials: P
authors.lastname: O'Connor
authors.forename: D
authors.initials: D
authors.lastname: McGonagle
authors.forename: C
authors.initials: C
authors.lastname: Pease
authors.forename: M J
authors.initials: MJ
authors.lastname: Green
authors.forename: D J
authors.initials: DJ
authors.lastname: Veale
authors.forename: J D
authors.initials: JD
authors.lastname: Isaacs
authors.forename: P
authors.initials: P
authors.lastname: Emery
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging*; D001842:Bone and Bones / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging*; D008875:Middle Aged; D011859:Radiography; D015203:Reproducibility of Results; D014463:Ultrasonography
chemical_list: D002097:C-Reactive Protein