title: Three-dimensional motion reconstruction and analysis of the right ventricle using tagged MRI.
abstract: Right ventricular (RV) dysfunction can serve as an indicator of heart and lung disease and can adversely affect the left ventricle. However, normal RV function must be characterized before abnormal states can be detected. We describe a method for reconstructing the 3D motion of the RV by fitting a deformable model to tag and contour data extracted from multiview tagged magnetic resonance images. The deformable model is a biventricular finite element mesh built directly from segmented contours. Our approach accommodates the geometrically complex RV by using the entire lengths of the tags, localized degrees of freedom, and finite elements for geometric modeling. Also, we outline methods for converting the 3D motion reconstruction results into potentially useful motion variables, such as strains and displacements. The technique was applied to synthetic data, two normal hearts, and two hearts with right ventricular hypertrophy (RVH). Noticeable differences were found between the motion variables calculated for normal volunteers and RVH patients.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA. haber@hub.tch.harvard.edu
authors.forename: I
authors.initials: I
authors.lastname: Haber
authors.forename: D N
authors.initials: DN
authors.lastname: Metaxas
authors.forename: L
authors.initials: L
authors.lastname: Axel
mesh_terms: D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D016278:Ventricular Function, Right