Relationship between susceptibility to hemolytic-uremic syndrome and levels of globotriaosylceramide in human sera.
The relationship between differential susceptibility to hemolytic-uremic syndrome (HUS) and levels of globotriaosylceramide (Gb3) in serum was studied in patients infected with verotoxin-producing Escherichia coli (VTEC). The serum Gb3 levels in patients with HUS were lower than these in diarrheal patients without subsequent HUS or in patients without clinical symptoms, indicating that individuals with a lower content of serum Gb3 show a higher incidence of HUS following VTEC infection.
Watarai
S
S
Laboratory of Veterinary Immunology, Department of Veterinary Science, College of Agriculture, Osaka Prefecture University, Sakai, Osaka, Japan.
Yokota
K
K
Tana
Kishimoto
T
T
Kanadani
T
T
Taketa
K
K
Oguma
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000097:blood / Q000382:microbiology; D004198:Disease Susceptibility; D004926:Escherichia coli / Q000235:genetics; D004927:Escherichia coli Infections / Q000097:blood* / Q000150:complications; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D022603:Shiga Toxins / Q000235:genetics; D014281:Trihexosylceramides / Q000097:blood*
D022603:Shiga Toxins; D014281:Trihexosylceramides; C018549:globotriaosylceramide