title: Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety.
abstract: 1Alpha,25-dihydroxyvitamin D3 diastereomer, differing from the parent compound in configuration at four asymmetric carbon atoms in the rings C/D and side chain (C13, C14, C17 and C20), was synthesized and shown to have a significant affinity for the vitamin D receptor.
authors.affiliation: Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw.
authors.forename: S
authors.initials: S
authors.lastname: Marczak
authors.forename: A
authors.initials: A
authors.lastname: Przezdziecka
authors.forename: J
authors.initials: J
authors.lastname: Wicha
authors.forename: A
authors.initials: A
authors.lastname: Steinmeyer
authors.forename: U
authors.initials: U
authors.lastname: Zügel
mesh_terms: D002117:Calcitriol / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D008968:Molecular Conformation; D015394:Molecular Structure; D011485:Protein Binding; D018167:Receptors, Calcitriol / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D018167:Receptors, Calcitriol; D002117:Calcitriol