Vandellia cordifolia regulated cell proliferation and cytokines production in human mononuclear cells.
Vandellia cordifolia (V. cordifolia) used for treatment inflammation in traditional Chinese medicine was selected for immunopharmacological activity test. The effects of V. cordifolia extracted fractions on human mononuclear cells (HMNC) proliferation were determined by tritiated thymidine uptake. The results indicated that VC-ME fraction suppressed HMNC proliferation activated with phytohemagglutinin (PHA) and stimulated cell cycle progression was arrested at the G0/G1 stage. The inhibitory mechanisms may involve the blocking of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) production, since VC-ME suppressed IL-2 and IFN-gamma production of HMNC in a dose-dependent manner. Therefore, it is suggested that immunomodulatory agents are contained in V. cordifolia.
Lin
A P
AP
Jen Ai Chinese Medical United Clinical, Taipei, Taiwan.
Tsai
W J
WJ
Fan
C Y
CY
Lee
M J
MJ
Kuo
Y C
YC
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005591:Chemical Fractionation; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016193:G1 Phase; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D010936:Plant Extracts; D016192:Resting Phase, Cell Cycle
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D007376:Interleukin-2; D008934:Mitogens; D010835:Phytohemagglutinins; D010936:Plant Extracts; D007371:Interferon-gamma