NMR interaction studies of aromatic guanyl hydrazones with micelles: model for mechanism of action of cationic antibiotics.
Interaction studies using hydrogen NMR spin-lattice relaxation time measurements of a series of five antiparasitic guanyl hydrazones with SDS and cetyl trimethylammonium bromide micelles are used as a simple model for the interaction of these compounds with the cell membrane of Trypanosoma cruzi. The results show that the activity of the compounds is related to their capacity to selectively interact with anionic micelles, which reinforces the hypothesis that the mechanism of action of these compounds is related to their selective interaction with the negatively charged parasite membrane.
Borges
M N
MN
Departamento de Química, Instituto Militar de Engenharia, Praça General Tibúrcio 80, 22290-270 Rio de Janeiro, Brazil.
Figueroa-Villar
J D
JD
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002412:Cations; D002462:Cell Membrane / Q000737:chemistry; D000077286:Cetrimonium; D002593:Cetrimonium Compounds; D014355:Chagas Disease / Q000209:etiology; D004195:Disease Models, Animal; D006147:Guanine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006835:Hydrazones / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D008958:Models, Molecular; D012967:Sodium Dodecyl Sulfate; D014349:Trypanosoma cruzi / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002412:Cations; D002593:Cetrimonium Compounds; D006835:Hydrazones; D008823:Micelles; D012967:Sodium Dodecyl Sulfate; D006147:Guanine; D000077286:Cetrimonium