Distribution of total 14C residue in egg yolk, albumen, and tissues following oral [14C]sulfamethazine administration to hens.
The distribution of total 14C residues was studied in egg yolk and albumen after administration of either single or multiple oral dosages of [14C]sulfamethazine (SMZ). One day after a single dose of [14C]SMZ (121 mg of sulfamethazine, 2.42 x 10(7) dpm), the 14C residue concentration peaked in egg albumen and egg yolk with the concentration in the former >4-fold greater than in the latter. Three days postdose, the 14C residue concentration in the yolk was approximately 7-fold higher than in the egg albumen. A multiple dose of [14C]SMZ containing sulfamethazine mass equivalent of an average therapeutic dose (282 mg, 2.9 x 10(7) dpm) for chickens was also administered orally for six consecutive days to hens. A significantly reduced level of egg production was observed during the medication, and most of the hens stopped laying eggs after the last dose. The 14C residue concentrations peaked on the last day (sixth) of medication in egg albumen and yolk. The 14C residue concentrations were also measured in liver, muscle, blood, and plasma of chickens sacrificed at 1, 24, 48, and 72 h after the last dose. Highest concentrations of 14C residue were accumulated in liver followed by, in decreasing order, blood, plasma, and muscle.
Shaikh
B
B
Center for Veterinary Medicine, U.S. Food and Drug Administration, 8401 Muirkirk Road, Laurel, Maryland 20708, USA. bshaikh@cmv.fda.gov
Chu
P S
PS
D000284:Administration, Oral; D000818:Animals; D001822:Body Burden; D002247:Carbon Isotopes; D002645:Chickens / Q000378:metabolism* / Q000502:physiology; D004350:Drug Residues; D004527:Egg Proteins / Q000032:analysis*; D004530:Egg Yolk / Q000737:chemistry*; D005260:Female; D005506:Food Contamination; D013418:Sulfamethazine / Q000008:administration & dosage*; D013997:Time Factors
D002247:Carbon Isotopes; D004527:Egg Proteins; D013418:Sulfamethazine