Interferon treatment on glomerulonephritis associated with hepatitis C virus.
We report on a 10-year-old girl with glomerulonephritis associated with hepatitis C virus infection, who was treated with interferon-alpha. On the first renal biopsy at 8 years of age, mild mesangial hypercellularity in a segmental to semiglobal pattern was present in all glomeruli. After 6 months interferon-alpha therapy, proteinuria diminished completely. However, mesangial proliferation was advanced on the second biopsy at 10 years of age. We concluded that the interferon-alpha was effective in the treatment of proteinuria despite the lack of pathological improvement.
Matsumoto
S
S
Department of Pediatrics, D-5, Developmental Medicine, Osaka University Graduate School of Medical Science, Suita, Osaka, 565-0871, Japan.
Nakajima
S
S
Nakamura
K
K
Etani
Y
Y
Hirai
H
H
Shimizu
N
N
Yokoyama
H
H
Kobayashi
Y
Y
Tajiri
H
H
Shima
M
M
Okada
S
S
D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy* / Q000635:transmission; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D007370:Interferon Type I / Q000627:therapeutic use*; D007668:Kidney / Q000473:pathology; D008854:Microscopy, Electron; D011994:Recombinant Proteins
D000998:Antiviral Agents; D007370:Interferon Type I; D011994:Recombinant Proteins