[The impact of alcohol and chronic liver disease of micronutrients metabolism].
Liver disease, alcohol and malnutrition are combinations usually associated with micronutrient impairment. Chronic liver disease courses with lower storage and activation of vitamin-coenzymes related to their malabsorption. Alcohol worsens the picture by reducing food intake, increasing micronutrients utilization and decreasing their absorption secondary to either intestinal or pancreatic injuries. Other concurrent causes would be drug treatments, urinary losses, protein deficiency and oxidative stress. As consequences the clinical signs are anemia, liver steatosis, oxidative stress and immunosuppression.
Maio
R
R
Centro de Metabolismo e Nutrição (CeMeNutri) da Faculdade de Medicina da Universidade Estadual Paulista-UNESP, Botucatu, SP.
Dichi
J B
JB
Burini
R C
RC
D000437:Alcoholism / Q000150:complications / Q000378:metabolism; D000740:Anemia / Q000209:etiology*; D001361:Avitaminosis / Q000209:etiology*; D002908:Chronic Disease; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000150:complications / Q000378:metabolism*; D018977:Micronutrients / Q000378:metabolism*; D018384:Oxidative Stress
D018977:Micronutrients