Successful prolonged cardiopulmonary resuscitation after a combined intoxication with a tricyclic antidepressant, a benzodiazepine and a neuroleptic.
We report the case of a patient who co-ingested a tricyclic antidepressant (amitriptyline), benzodiazepines (alprazolam and lormetazepam) and a neuroleptic drug (prothipendyl). Major neurologic and cardiac symptoms occurred including a prolonged cardiac arrest. The cardiopulmonary resuscitation phase was complicated by a haematoma of the liver treated by a left hepatectomy. The clinical features and management of this combined intoxication are discussed.
Christiaens
F
F
Department of Critical Care, University Hospital, Vrije Universiteit Brussel, Brussels, Belgium.
Lessire
H
H
Dellers
I
I
Denis
B
B
Vankeerberghen
L
L
Verborgh
C
C
D000328:Adult; D000525:Alprazolam / Q000506:poisoning*; D000639:Amitriptyline / Q000506:poisoning*; D014151:Anti-Anxiety Agents / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D014150:Antipsychotic Agents / Q000506:poisoning*; D001569:Benzodiazepines; D016887:Cardiopulmonary Resuscitation; D004630:Emergencies; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000031:analogs & derivatives* / Q000506:poisoning*; D013406:Suicide, Attempted; D013843:Thiazines / Q000506:poisoning*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D013843:Thiazines; D001569:Benzodiazepines; D000639:Amitriptyline; C069248:prothipendyl; C023842:lormetazepam; D008140:Lorazepam; D000525:Alprazolam