title: The interaction between anticoagulant protein S and complement regulatory C4b-binding protein (C4BP).
abstract: An important mechanism of regulation of blood coagulation is the anticoagulant protein C pathway. In this pathway, the anticoagulant activity of activated protein C is increased by its cofactor protein S. The cofactor activity of protein S can be regulated by binding to complement regulatory C4b-binding protein (C4BP). The sites of interaction of protein S and C4BP are discussed.
authors.affiliation: Department of Haematology, University Medical Center Utrecht, the Netherlands.
authors.forename: R H
authors.initials: RH
authors.lastname: van de Poel
authors.forename: J C
authors.initials: JC
authors.lastname: Meijers
authors.forename: B N
authors.initials: BN
authors.lastname: Bouma
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000097:blood*; D001665:Binding Sites; D001777:Blood Coagulation / Q000502:physiology; D015935:Complement C4b / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D016167:Integrin alphaXbeta2 / Q000097:blood*; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000925:Anticoagulants; D016167:Integrin alphaXbeta2; D011486:Protein C; D017293:Protein S; D015935:Complement C4b