title: Trityl isothiocyanate support for solid-phase synthesis.
abstract: Trityl isothiocyanate resin [1], prepared from commercially available trityl chloride resin, is a useful precursor of the trityl thiosemicarbazide resin [2]. This resin can be employed in the solid-phase synthesis of a variety of supported isatin beta-thiosemicarbazones [4] and their Mannich derivatives [6]. A variety of thioureas [7] can be easily prepared by the reaction of [1] with amines. The supported thioureas are directly and efficiently converted to 2-aminothiazole-5-carboxylates [8] by reaction with methyl 2-chloroacetoacetate.
authors.affiliation: Department of Chemistry, Levine Science Research Center, Duke University, Durham, North Carolina 27708-0317, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Pirrung
authors.forename: S V
authors.initials: SV
authors.lastname: Pansare
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007510:Isatin / Q000737:chemistry*; D017879:Isothiocyanates; D009682:Magnetic Resonance Spectroscopy; D008352:Mannich Bases / Q000138:chemical synthesis*; D012116:Resins, Plant; D013844:Thiazoles / Q000138:chemical synthesis*; D013882:Thiosemicarbazones / Q000737:chemistry; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D017879:Isothiocyanates; D008352:Mannich Bases; D012116:Resins, Plant; D013844:Thiazoles; D013882:Thiosemicarbazones; D007510:Isatin; D013890:Thiourea