title: An outbreak of asthma in a modern detergent factory.
abstract: The striking decrease in the occurrence of protease-induced occupational asthma in the detergent Industry has been attributed to enzyme encapsulation. We report an outbreak of asthma, at least equal in size to those reported in the 1960s, in a modem European factory which has exclusively used encapsulated enzymes. A survey revealed that enzyme sensitisation and work-related respiratory symptoms were positively correlated with airborne enzyme exposure. We suggest that encapsulation alone is insufficient to prevent enzyme-Induced allergy and asthma.
authors.forename: P
authors.initials: P
authors.lastname: Cullinan
authors.forename: J M
authors.initials: JM
authors.lastname: Harris
authors.forename: A J
authors.initials: AJ
authors.lastname: Newman Taylor
authors.forename: A M
authors.initials: AM
authors.lastname: Hole
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: F
authors.initials: F
authors.lastname: Barnes
authors.forename: G
authors.initials: G
authors.lastname: Jolliffe
mesh_terms: D000293:Adolescent; D000328:Adult; D000681:Amylases / Q000009:adverse effects; D001249:Asthma / Q000453:epidemiology / Q000209:etiology*; D002480:Cellulase / Q000009:adverse effects; D003902:Detergents / Q000009:adverse effects*; D004196:Disease Outbreaks; D010450:Endopeptidases / Q000009:adverse effects; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012882:Skin Tests
chemical_list: D003902:Detergents; D000681:Amylases; D002480:Cellulase; D010450:Endopeptidases