Synthesis and antimycobacterial activity of some 4H-1,2,4-triazin-5-one derivatives.
6-[(Arylmethylenamino)carbonyl]-3-(pyridin-2-yl)-4H-1,2,4-triazin-5-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis.
Mamolo
M G
MG
Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy. mamolo@univ.trieste.it
Falagiani
V
V
Zampieri
D
D
Vio
L
L
Banfi
E
E
D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009162:Mycobacterium avium / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000995:Antitubercular Agents; D014227:Triazines