Porins and lipopolysaccharide induce apoptosis in human spermatozoa.
Treatment of human spermatozoa with porins or lipopolysaccharide (LPS) increases spontaneous apoptosis in these cells. Porins and LPS were extracted from Salmonella enterica serovar Typhimurium and Pasteurella multocida and were mixed with human spermatozoa for detection of levels of apoptosis.
Gorga
F
F
Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy. francesco.galdiero@unina2.it
Galdiero
M
M
Buommino
E
E
Galdiero
E
E
D017209:Apoptosis; D002470:Cell Survival / Q000187:drug effects; D053938:DNA Fragmentation; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D016979:Pasteurella multocida; D011112:Polymyxin B / Q000494:pharmacology; D018272:Porins / Q000378:metabolism* / Q000494:pharmacology; D012486:Salmonella typhimurium; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology*
D008070:Lipopolysaccharides; D018272:Porins; D011112:Polymyxin B