title: Statistical optimization of a sustained-release matrix tablet of lobenzarit disodium.
abstract: The statistical optimization of sustained-release matrix tablets of lobenzarit disodium salt (LDS) was performed using the central composite experiment design 2(3) for three independent variables: the amount of polymer (Eudragit RS-PO) AP, the total volume of granulation solvent VS, and the amount of filler (microcrystalline cellulose) CE. The t90% was selected as the response variable. The response surfaces were performed from a statistical mathematical model. The optimal formulation was obtained for the variables (AP = 15 mg, VS = 60 microliters, and CE = 0).
authors.affiliation: Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Havana, Cuba.
authors.forename: A
authors.initials: A
authors.lastname: Boza
authors.forename: Y
authors.initials: Y
authors.lastname: De la Cruz
authors.forename: G
authors.initials: G
authors.lastname: Jordán
authors.forename: U
authors.initials: U
authors.lastname: Jáuregui-Haza
authors.forename: A
authors.initials: A
authors.lastname: Alemán
authors.forename: I
authors.initials: I
authors.lastname: Caraballo
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002482:Cellulose / Q000737:chemistry; D003692:Delayed-Action Preparations; D006801:Humans; D008962:Models, Theoretical; D011108:Polymers; D012997:Solvents; D013607:Tablets; D062367:ortho-Aminobenzoates / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011108:Polymers; D012997:Solvents; D013607:Tablets; D062367:ortho-Aminobenzoates; D002482:Cellulose; C015735:lobenzarit