Use of penicillin MICs to predict in vitro activity of other beta-lactam antimicrobial agents against Streptococcus pneumoniae.
Linear regression analysis was used to compare penicillin MICs determined with 3,129 recent clinical isolates of Streptococcus pneumoniae to MICs obtained with nine other beta-lactam antimicrobial agents. A strong correlation between penicillin MICs and those obtained with other beta-lactams was demonstrated. It may be possible to test penicillin and use MICs obtained with penicillin to predict MICs of other beta-lactam antimicrobials for Streptococcus pneumoniae.
Brueggemann
A B
AB
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
Pfaller
M A
MA
Doern
G V
GV
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D016014:Linear Models; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D011008:Pneumococcal Infections / Q000382:microbiology; D011237:Predictive Value of Tests; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010406:Penicillins; D047090:beta-Lactams