title: Evaluation of pleomorphic xanthoastrocytoma by use of positron emission tomography with.
abstract: We present a case of pleomorphic xanthoastrocytoma (PXA) in a patient with temporal lobe seizures. Imaging sequences included MR, and results of positron emission tomography (PET) with [18F]-fluorodeoxyglucose (FDG) and [11C]-methionine (Met) tracers revealed a hypermetabolic region equivalent or nearly equivalent to normal cerebral cortex, suggesting that the tumor might have malignant potential. Histopathologic findings indicated low-grade glioma. The mechanism for glucose hypermetabolic activity of PXA is not clear; however, the positive findings obtained from FDG-PET may not always indicate the degree of malignancy associated with PXA.
authors.affiliation: Department of Neurosurgery, Osaka City University Medical School, Osaka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Tsuyuguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: I
authors.initials: I
authors.lastname: Sunada
authors.forename: Y
authors.initials: Y
authors.lastname: Matsusaka
authors.forename: M
authors.initials: M
authors.lastname: Haque
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008715:Methionine; D011859:Radiography; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine