[Effect of preliminary adaptive irradiation on the concentration of lipid peroxidation products in blood serum and degradation of DNA in thymus of irradiated mice].
The animals were irradiated within adaptive dose of 0.1 Gy and 5 hours later with a challenge dose of 2 Gy. The adaptive dose reduced the effects induced by the challenge dose of 2 Gy: the increased content of the products of lipid peroxidation reactive to thiobarbituric acid in blood serum, and the increased number of breaks in thymus DNA of irradiated mice.
Riabchenko
N I
NI
Medical Radiology Research Centre, Russian Academy of Medical Sciences, Obninsk, 249020 Russia.
Ivannik
B P
BP
Khorokhorina
V A
VA
Dzikovskaia
L A
LA
Sin'kova
R V
RV
Riabchenko
V I
VI
Grosheva
I P
IP
Degtiareva
E V
EV
D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D015415:Biomarkers; D004247:DNA / Q000235:genetics / Q000528:radiation effects*; D004249:DNA Damage / Q000235:genetics*; D004307:Dose-Response Relationship, Radiation; D015227:Lipid Peroxidation / Q000528:radiation effects*; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000235:genetics; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D004247:DNA