title: Gastric dysrhythmias occur in gastro-oesophageal reflux disease complicated by food regurgitation but not in uncomplicated reflux.
abstract: OBJECTIVE
  To investigate gastric pacemaker activity in gastro-oesophageal reflux disease using the electrogastrogram.
  
  
  METHODS
  Forty patients with gastro-oesophageal reflux disease (20 with acid reflux, 20 with the additional symptom of food regurgitation) and 30 asymptomatic controls.
  
  
  METHODS
  Patients were studied using an electrogastrogram, oesophageal manometry, and 24 hour ambulatory oesophageal pH analysis.
  
  
  RESULTS
  An abnormal electrogastrogram was recorded in two (7%) controls, two (10%) patients with acid reflux, and 10 (50%) patients with food regurgitation. Food regurgitators had significantly more gastric dysrhythmias (tachygastrias) both before (p<0.02) and after (p<0.01) a test meal. Gastric pacemaker activity was also significantly less stable following the test meal in food regurgitators (p<0.003). Patients with food regurgitation and an abnormal electrogastrogram had higher oesophageal acid exposure than those with a normal electrogastrogram (p<0.05).
  
  
  CONCLUSIONS
  The electrogastrogram is usually normal in gastro-oesophageal reflux disease but an abnormal rhythm occurred in half of our patients with the additional symptom of food regurgitation. Furthermore, an abnormal electrogastrogram is associated with increased oesophageal acid exposure.
authors.affiliation: Department of Gastroenterology, Royal Free Hospital, Pond St, London NW3 2QG, UK.
authors.forename: A
authors.initials: A
authors.lastname: Leahy
authors.forename: K
authors.initials: K
authors.lastname: Besherdas
authors.forename: C
authors.initials: C
authors.lastname: Clayman
authors.forename: I
authors.initials: I
authors.lastname: Mason
authors.forename: O
authors.initials: O
authors.lastname: Epstein
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004576:Electromyography; D005260:Female; D005583:Fourier Analysis; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric