The mannan-binding-lectin pathway of the innate immune response.
Dramatic progress has been achieved during the past year in our understanding of how the complement system is activated via the mannan-binding-lectin pathway. Surprising discoveries have changed our concepts of the complexes that are formed upon engagement of mannan-binding lectin with its serine proteases.
Gadjeva
M
M
The Center for Blood Research, Harvard Medical School, 221 Longwood Avenue, Boston, MA 01215, USA. gadjeva@cbr.med.harvard.edu
Thiel
S
S
Jensenius
J C
JC
D000818:Animals; D002352:Carrier Proteins / Q000276:immunology* / Q000378:metabolism* / Q000502:physiology; D037222:Collectins; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D037102:Lectins / Q000276:immunology* / Q000378:metabolism; D008351:Mannans / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
D002352:Carrier Proteins; D037222:Collectins; D037102:Lectins; D008351:Mannans