Interaction between factor VIII and LDL receptor-related protein. Modulation of coagulation?
Recent reports suggest that the multifunctional receptor low-density lipoprotein receptor-related protein (LRP) may contribute to the regulation of blood coagulation by mechanisms that differ from the simple removal of protease/inhibitor complexes from the circulation. This possibility became apparent from the observation that LRP is involved in down-regulation of Tissue Factor expression at the surface of monocytes and fibroblasts. Furthermore, coagulation Factor VIII and activated Factor IX (Factor IXa) have been identified as proteins that are able to bind to LRP. In the present review, the potential contribution of LRP to the regulation of the coagulation cascade through these novel pathways is discussed, with particular reference to the interaction between LRP and coagulation Factor VIII.
Neels
J G
JG
Department of Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Bovenschen
N
N
van Zonneveld
A J
AJ
Lenting
P J
PJ
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D004347:Drug Interactions; D005169:Factor VIII / Q000378:metabolism*; D015944:Factor VIIIa / Q000378:metabolism; D006801:Humans; D008024:Ligands; D011973:Receptors, LDL / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism
D008024:Ligands; D011973:Receptors, LDL; D014841:von Willebrand Factor; D015944:Factor VIIIa; D005169:Factor VIII