title: Computational modeling of RBC and neutrophil transit through the pulmonary capillaries.
abstract: A computational model of the pulmonary microcirculation is developed and used to examine blood flow from arteriole to venule through a realistically complex alveolar capillary bed. Distributions of flow, hematocrit, and pressure are presented, showing the existence of preferential pathways through the system and of large segment-to-segment differences in all parameters, confirming and extending previous work. Red blood cell (RBC) and neutrophil transit are also analyzed, the latter drawing from previous studies of leukocyte aspiration into micropipettes. Transit time distributions are in good agreement with in vivo experiments, in particular showing that neutrophils are dramatically slowed relative to the flow of RBCs because of the need to contract and elongate to fit through narrower capillaries. Predicted neutrophil transit times depend on how the effective capillary diameter is defined. Transient blockage by a neutrophil can increase the local pressure drop across a segment by 100--300%, leading to temporal variations in flow and pressure as seen by videomicroscopy. All of these effects are modulated by changes in transpulmonary pressure and arteriolar pressure, although RBCs, neutrophils, and rigid microspheres all behave differently.
authors.affiliation: Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: C M
authors.initials: CM
authors.lastname: Doerschuk
authors.forename: R D
authors.initials: RD
authors.lastname: Kamm
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D002196:Capillaries / Q000033:anatomy & histology / Q000502:physiology; D002465:Cell Movement; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000502:physiology*; D008168:Lung / Q000098:blood supply / Q000166:cytology / Q000502:physiology; D008863:Microspheres; D008962:Models, Theoretical; D009504:Neutrophils / Q000166:cytology / Q000502:physiology*; D011652:Pulmonary Circulation; D012680:Sensitivity and Specificity; D013997:Time Factors