Current cases in which epitope mimicry is considered a component cause of autoimmune disease: Guillain-Barré syndrome.
Some patients develop Guillain-Barré syndrome (GBS) after the administration of bovine gangliosides. Patients with GBS subsequent to Campylobacter jejuni enteritis frequently have IgG antibody to GM1 ganglioside. Miller Fisher syndrome (MFS), a variant of GBS, is associated with IgG antibody to GQ1b ganglioside. Molecular mimicry between GM1 and lipopolysaccharide of C. jejuni isolated from patients with GBS, and between GQ1b and C. jejuni lipopolysaccharides from patients with MFS have been demonstrated. The molecular mimicry between infectious agents and gangliosides may function in the production of anti-ganglioside antibodies. This sugar mimicry is one possible cause of the Guillain-Barré and Miller Fisher syndromes; however, unidentified host factors may contribute to the development of these syndromes.
Yuki
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Department of Neurology, Dokkyo University School of Medicine, Shimotsuga, Tochigi, Japan. yuki@dokkyomed.ac.jp
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology; D002169:Campylobacter Infections / Q000276:immunology*; D016123:Campylobacter jejuni / Q000276:immunology*; D002417:Cattle; D018985:Epitopes, B-Lymphocyte / Q000276:immunology*; D005677:G(M1) Ganglioside / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D019846:Miller Fisher Syndrome / Q000209:etiology / Q000276:immunology*; D018716:Molecular Mimicry / Q000276:immunology*
D000942:Antigens, Bacterial; D001324:Autoantigens; D018985:Epitopes, B-Lymphocyte; D005732:Gangliosides; D008070:Lipopolysaccharides; D005677:G(M1) Ganglioside; C039129:GQ1b ganglioside