Tubelactomicin A, a novel 16-membered lactone antibiotic, from Nocardia sp. I. Taxonomy, production, isolation and biological properties.
A novel 16-membered lactone antibiotic named tubelactomicin A was isolated from the culture broth of an actinomycete strain. The producing organism, designated MK703-102F1, was identified as a member of Nocardia. Tubelactomicin A was isolated from the culture broth by Diaion HP20 absorption, ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies and centrifugal liquid-liquid partition chromatography (CPC). Tubelactomicin A showed strong activity against acid-fast bacteria including the drug-resistant strains.
Igarashi
M
M
Institute of Microbial Chemistry, Tokyo, Japan.
Hayashi
C
C
Homma
Y
Y
Hattori
S
S
Kinoshita
N
N
Hamada
M
M
Takeuchi
T
T
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003470:Culture Media; D004352:Drug Resistance, Microbial; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D009615:Nocardia / Q000145:classification* / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D007783:Lactones; C418197:tubelactomicin A