Actin dynamics: assembly and disassembly of actin networks.
Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP(2) and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as filaments age.
Wear
M A
MA
Department of Cell Biology and Physiology, Washington University, Box 8228, 660 S. Euclid Avenue, St. Louis, Missouri 63110, USA.
Schafer
D A
DA
Cooper
J A
JA
D000199:Actins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism*; D008954:Models, Biological; D011108:Polymers / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D051316:Wiskott-Aldrich Syndrome Protein
D000199:Actins; D008840:Microfilament Proteins; D011108:Polymers; D011506:Proteins; C495767:WAS protein, human; D051316:Wiskott-Aldrich Syndrome Protein