Perception of pain coincides with the spatial expansion of electroencephalographic dynamics in human subjects.
The dynamics of cortex driven by painful median nerve stimulation were investigated in event-related oscillation (ERO). We applied a wavelet time-frequency analysis to differentiate the brain dynamics between painful and non-painful somatosensory stimulation. The observed pattern to pain-induced effects exhibited a stepwise decrease of frequencies over time, starting around 26 ms over somatosensory cortex at 80 Hz, intermediate oscillations at 40 and 20 Hz around 40 ms, and reaching down to 10 Hz after 160 ms. This step-wise frequency decrease of ERO, coincident with spatial shift from the contralateral somatosensory area at 80 Hz to the centro-frontal brain at 40/20 Hz and final spatial expansion to the large region of centro-parietal areas at 10 Hz, may represent the cortical processes necessary to transfer sensory information from perceptual stages to subsequent cognitive stages in consciousness.
Chen
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AC
Human Brain Mapping and Cortical Imaging Laboratory, The International Doctoral School in Biomedical Sciences and Engineering, SMI, Aalborg University, Fred Bayers Vej 7D3, DK-9220, Aalborg, Denmark. ac@smi.auc.dk
Herrmann
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CS
D000328:Adult; D001683:Biological Clocks; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D004569:Electroencephalography; D004585:Electrooculography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D010147:Pain Measurement; D010296:Parietal Lobe / Q000502:physiology; D010465:Perception / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology