title: Expression of CD44 and its variant isoform v3 has no prognostic value in gastric cancer.
abstract: OBJECTIVE
  To study the controversial role of transmembrane glycoprotein CD44 as a moderator of tumour spread and as a prognostic factor in gastric cancer.
  
  
  RESULTS
  The expression of all CD44 forms and that with exon v3 was assessed in 198 stage I-IV gastric adenocarcinomas using immunohistochemistry. CD44 expression was found in 72% and CD44v3 in 55% of the cases. The intensity of CD44 expression was associated with the level of invasion and with hyaluronan expression, while the frequency of CD44 positive cells was not significantly related to any of the clinical or histological features of the tumours. CD44v3 expression failed to show any association with the clinical or histological variables examined. Neither total CD44 nor CD44v3 expression affected survival. The most important prognostic factors in this cohort were the level of invasion, lymph node status, tumour size and vascular or perineural invasion.
  
  
  CONCLUSIONS
  Changes in CD44 or CD44v3 expression level do not predict tumour spread or patient survival in gastric cancer.
authors.affiliation: Department of Surgery, Kuopio University Hospital, Finland. leena.setala@kuh.fi
authors.forename: L
authors.initials: L
authors.lastname: Setälä
authors.forename: P
authors.initials: P
authors.lastname: Lipponen
authors.forename: R
authors.initials: R
authors.lastname: Tammi
authors.forename: M
authors.initials: M
authors.lastname: Tammi
authors.forename: M
authors.initials: M
authors.lastname: Eskelinen
authors.forename: E
authors.initials: E
authors.lastname: Alhava
authors.forename: V M
authors.initials: VM
authors.lastname: Kosma
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000368:Aged; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: C121450:CD44V3,8-10; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid