title: Semiotes: a semantics for sharing.
abstract: BACKGROUND
  Reliable, automated communication of biological information requires methods to declare the information's semantics. In this paper I describe an approach to semantic declaration intended to permit independent, distributed databases, algorithms, and servers to exchange and process requests for information and computations without requiring coordination or agreement among them on universe of discourse, data model, schema, or implementation.
  
  
  RESULTS
  This approach uses Glossa, a formal language defining the semantics of biological ideas, information, and algorithms, to executably define the semantics of complex ideas and computations by constructs of semiotes, terms which axiomatically define very simple notions. A database or algorithm wishing to exchange information or computations maintains a set of mappings between its particular notions and semiotes, and a parser to translate between its indigenous ideas and implementation and the semiotes. Requests from other databases or algorithms are issued as semiotic messages, locally interpreted and processed, and the results returned as semiotes to the requesting entity. Thus, semiotes serve as a shared, abstract layer of definitions which can be computably combined by each database or algorithm according to its own needs and ideas. By combining the explicit declaration of semantics with the computation of the semantics of complex ideas, Glossa and its semiotes permit independent computational entities to lightly federate their capabilities as desired while maintaining their unique perspectives on both scientific and technical questions.
authors.affiliation: Institute for Biomedical Computing, Washington University, 700 South Euclid Avenue, St. Louis, MO 63110, USA. toni@athe.wustl.edu
authors.forename: T
authors.initials: T
authors.lastname: Kazic
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D016208:Databases, Factual; D012660:Semantics; D012984:Software