T-cell/natural killer cell lymphoblastic lymphoma with an unusual coexpression of B-cell antigens.
Lymphoblastic lymphomas are usually B- or T-cell neoplasms. There exists a small group of T-cell lymphomas additionally coexpressing cytotoxic or natural killer (NK)-cell markers, supporting the hypothesis of a common T/NK-cell precursor and respective neoplasms. Clinically, lymphatic neoplasms of T/NK-cell phenotype are either extranodal lymphomas or acute leukemias. The clinical course of these T/NK neoplasms cannot be predicted by morphology and/or phenotype alone. However, the expression of a heterogeneous (T + NK or myeloid) marker profile or of "early" antigens (such as TdT, CD10, RAG1, RAG2) render them more likely to be in the acute leukemia group. We present a case of a 63-year-old woman with a bone marrow infiltrate, enlarged lymph nodes, and B-symptoms. A cervical lymph node biopsy showed a monomorphic blastic infiltrate with a T-cell phenotype, coexpressing NK markers (CD56, CD57, NK1) and B-cell antigens (CD20, CD79). To the best of our knowledge, this is a newly recognized phenotype that has not been reported before. T/NK-cell lymphomas, including blastic NK-cell leukemia/lymphoma and T-lymphoblastic lymphomas, have to be included in the differential diagnosis. Both groups have a different clinical behavior and prognosis. In particular, T/NK-cell lymphomas associated with an Epstein Barr virus infection are clinically very aggressive neoplasms.
Gloeckner-Hofmann
K
K
Institute of Pathology, Medical University of Luebeck, Germany.
Ottesen
K
K
Schmidt
S
S
Nizze
H
H
Feller
A C
AC
Merz
H
H
D000941:Antigens / Q000096:biosynthesis; D000951:Antigens, Neoplasm / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology; D001706:Biopsy; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D009333:Neck; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology* / Q000473:pathology*
D000941:Antigens; D000951:Antigens, Neoplasm