title: Carcinoma in situ in the testis.
abstract: Carcinoma in situ (CIS) of the testis is a common precursor of germ-cell tumours in adults and adolescents, with the exception of spermatocytic seminoma. This article reviews existing knowledge on the pathobiology, genetic aspects and epidemiology of CIS, discusses current hypotheses concerning pathogenesis and invasive progression of germ-cell neoplasms and provides guidelines for diagnosis and clinical management of CIS.
authors.affiliation: Department of Oncology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark. mroerth@rh.dk
authors.forename: M
authors.initials: M
authors.lastname: Rørth
authors.forename: E
authors.initials: E
authors.lastname: Rajpert-De Meyts
authors.forename: L
authors.initials: L
authors.lastname: Andersson
authors.forename: K P
authors.initials: KP
authors.lastname: Dieckmann
authors.forename: S D
authors.initials: SD
authors.lastname: Fosså
authors.forename: K M
authors.initials: KM
authors.lastname: Grigor
authors.forename: W F
authors.initials: WF
authors.lastname: Hendry
authors.forename: H W
authors.initials: HW
authors.lastname: Herr
authors.forename: L H
authors.initials: LH
authors.lastname: Looijenga
authors.forename: J W
authors.initials: JW
authors.lastname: Oosterhuis
authors.forename: N E
authors.initials: NE
authors.lastname: Skakkebaek
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics; D002278:Carcinoma in Situ / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D006801:Humans; D015994:Incidence; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D017410:Practice Guidelines as Topic; D013736:Testicular Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology*; D013737:Testis / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor