title: Duplication of the leg--renal agenesis: congenital malformation syndrome.
abstract: A case is given of a male born with a duplication of the left leg and ipsilateral kidney agenesis. Although the etiology is unknown, we believe this association represents a congenital malformation syndrome. It is a polytopic developmental field defect. The growth factor IGF-I produced by the intermediary mesoderm or mesonephros (embryonary kidney) could be implicated in the induction limb development and the application of FGF-8 protein to the flank of young chick embryos inducing the development of additional limbs. It is possible that one or more of the growth factors produced by the mesonephros take some cells of the intermediary mesoderm out of their renal way to form a supernumerary limb.
authors.affiliation: Department of Orthopaedic Surgery, Hospital Archet, BP 3079 F06202 Nice, France.
authors.forename: J
authors.initials: J
authors.lastname: Griffet
authors.forename: F
authors.initials: F
authors.lastname: Bastiani-Griffet
authors.forename: S
authors.initials: S
authors.lastname: Jund
authors.forename: M
authors.initials: M
authors.lastname: Moreigne
authors.forename: K F
authors.initials: KF
authors.lastname: Zabjek
mesh_terms: D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000032:analysis; D006801:Humans; D007223:Infant; D007668:Kidney / Q000002:abnormalities* / Q000601:surgery*; D007866:Leg / Q000002:abnormalities*; D017880:Limb Deformities, Congenital / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery*; D008297:Male; D017689:Polydactyly / Q000000981:diagnostic imaging / Q000601:surgery; D011859:Radiography; D017526:Receptor, IGF Type 1 / Q000032:analysis; D013577:Syndrome; D014034:Toes / Q000002:abnormalities*
chemical_list: C496456:FGF8 protein, human; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors; D017526:Receptor, IGF Type 1