title: [Mitomycin C in open angle glaucoma surgery with previous failed glaucoma surgery].
abstract: OBJECTIVE
  This study investigates the results of trabeculectomy with peroperative topical application of mitomycin-C performed on eyes with previous failed glaucoma filtering surgery.
  
  
  METHODS
  The study includes 34 eyes of 26 patients operated on open angle glaucoma between March 1992 and October 1996, with a minimum of 6 months follow-up (mean 28.1 months). All the eyes had undergone prior one (27) o two (7) filtering surgeries. We evaluated intraocular pressure (IOP) and treatment reduction after surgery. Success was defined as IOP <20 mmHg, without deterioration of the visual field and/or papilla and without oral carbonic anhydrase inhibitors (OCAI) treatment.
  
  
  RESULTS
  Average IOP decrease (p<0,001) from 21.06+/-3.70 mmHg to 13.88+/-2.42 mmHg after surgery and the number of medications dropped from 2.44+/-0.69 to 0.68+/-1.02 (p<0.01). The success rate was 88.2%. The major complication was hypotony maculopathy in 3 eyes (8.8%).
  
  
  CONCLUSIONS
  Trabeculectomy with mitomycin-C decreases IOP and postoperative medications in eyes with previous unsuccessful filtering surgery.
authors.affiliation: Complejo Hospitalario Universitario de Santiago de Compostela, La Coruña, España.
authors.lastname: Martínez García A
authors.lastname: Pérez García R
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D012086:Reoperation; D017211:Treatment Failure
chemical_list: D016685:Mitomycin