title: Adaptive electric field control of epileptic seizures.
abstract: We describe a novel method of adaptively controlling epileptic seizure-like events in hippocampal brain slices using electric fields. Extracellular neuronal activity is continuously recorded during field application through differential extracellular recording techniques, and the applied electric field strength is continuously updated using a computer-controlled proportional feedback algorithm. This approach appears capable of sustained amelioration of seizure events in this preparation when used with negative feedback. Seizures can be induced or enhanced by using fields of opposite polarity through positive feedback. In negative feedback mode, such findings may offer a novel technology for seizure control. In positive feedback mode, adaptively applied electric fields may offer a more physiological means of neural modulation for prosthetic purposes than previously possible.
authors.affiliation: Krasnow Institute for Advanced Study, and Departments of Physics and Astronomy and Psychology, George Mason University, Fairfax, Virginia, 22030, USA. bgluckma@gmu.edu
authors.forename: B J
authors.initials: BJ
authors.lastname: Gluckman
authors.forename: H
authors.initials: H
authors.lastname: Nguyen
authors.forename: S L
authors.initials: SL
authors.lastname: Weinstein
authors.forename: S J
authors.initials: SJ
authors.lastname: Schiff
mesh_terms: D000465:Algorithms; D000818:Animals; D004599:Electric Stimulation Therapy / Q000379:methods*; D004563:Electrochemistry; D004594:Electrophysiology; D004827:Epilepsy / Q000503:physiopathology* / Q000628:therapy*; D005246:Feedback; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D008839:Microelectrodes; D009415:Nerve Net / Q000503:physiopathology; D009433:Neural Inhibition; D051381:Rats; D017207:Rats, Sprague-Dawley; D012684:Sensory Thresholds; D012815:Signal Processing, Computer-Assisted