title: Achieving pregnancy against the odds: successful implantation of frozen-thawed embryos generated by ICSI using spermatozoa banked prior to chemo/radiotherapy for Hodgkin's disease and acute leukaemia.
abstract: Two cases are reported of successful pregnancies following long-term semen banking prior to chemotherapy and radiotherapy for malignancy. With the first case, the patient banked semen at the age of 20 years prior to chemotherapy for Hodgkin's disease; 11 years later the thawed semen was used for IVF with intracytoplasmic sperm injection (ICSI), resulting in twins being born following the transfer of frozen-thawed embryos. In the second case, the patient banked semen at the age of 17 years prior to chemotherapy and radiotherapy for acute myeloid leukaemia; 8 years later it was used for ICSI, resulting in triplets being born following the transfer of frozen-thawed embryos. These cases support long-term semen banking for men whose future fertility may be compromised by suppression of spermatogenesis secondary to administration of chemo/radiotherapy treatment. The advent of successful ICSI combined with embryo cryopreservation has increased the chance of thawed cryopreserved semen achieving fertilization. Banking of a single ejaculate prior to commencement of chemotherapy/radiotherapy treatment may preserve potential fertility without compromising the oncology treatment.
authors.affiliation: Department of Reproductive Medicine, St Mary's Hospital, Manchester M13 0JH, UK. greg.smh1.cmht.nwest.nhs.uk
authors.forename: G
authors.initials: G
authors.lastname: Horne
authors.forename: A
authors.initials: A
authors.lastname: Atkinson
authors.forename: D R
authors.initials: DR
authors.lastname: Brison
authors.forename: J
authors.initials: J
authors.lastname: Radford
authors.forename: J A
authors.initials: JA
authors.lastname: Yin
authors.forename: E C
authors.initials: EC
authors.lastname: Edi-Osagie
authors.forename: E H
authors.initials: EH
authors.lastname: Pease
authors.forename: B A
authors.initials: BA
authors.lastname: Lieberman
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D015925:Cryopreservation; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000532:radiotherapy*; D008297:Male; D009845:Oligospermia / Q000209:etiology / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D012662:Semen Preservation; D020554:Sperm Injections, Intracytoplasmic; D013091:Spermatogenesis / Q000187:drug effects / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents