title: Differential patterns of sympathetic responses to selective stimulation of nucleus tractus solitarius purinergic receptor subtypes.
abstract: 1. Studies are described that indicate that stimulation of different purinergic receptor subtypes (A1, A2A and P2X) located in the sub-postremal nucleus tractus solitarius (NTS) evokes qualitatively and quantitatively different regional haemodynamic and efferent sympathetic responses. 2. Stimulation of A2A receptors evoked the most diverse pattern of regional sympathetic responses: preganglionic adrenal nerve activity (pre-ASNA) was increased, lumbar sympathetic nerve activity (LSNA) did not change, while renal (RSNA) and post-ganglionic adrenal (post-ASNA) sympathetic nerve activity was decreased. Stimulation of A1 receptors evoked qualitatively uniform, although quantitatively different, sympathoactivation: pre-ASNA > RSNA > LSNA. Stimulation of P2X receptors evoked qualitatively uniform, although quantitatively different, sympathoinhibition: RSNA=post-ASNA > LSNA = pre-ASNA. 3. These qualitatively and quantitatively different patterns of regional sympathetic responses strongly suggest that purinergic receptor subtypes may be specifically located and differentially expressed on NTS neurons/neural terminals that control different sympathetic outputs. Different NTS purinoceptors may contribute to patterned autonomic responses observed in specific physiological or pathological situations.
authors.affiliation: Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. tscislo@med.wayne.edu
authors.forename: T J
authors.initials: TJ
authors.lastname: Scislo
authors.forename: A M
authors.initials: AM
authors.lastname: Kitchen
authors.forename: R A
authors.initials: RA
authors.lastname: Augustyniak
authors.forename: D S
authors.initials: DS
authors.lastname: O'Leary
mesh_terms: D000313:Adrenal Medulla / Q000502:physiology; D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D006801:Humans; D007668:Kidney / Q000502:physiology; D043705:Receptor, Adenosine A2A; D011983:Receptors, Purinergic / Q000502:physiology; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D018048:Receptors, Purinergic P2 / Q000502:physiology*; D058476:Receptors, Purinergic P2X2; D017552:Solitary Nucleus / Q000502:physiology*
chemical_list: C546401:P2RX2 protein, human; D043705:Receptor, Adenosine A2A; D011983:Receptors, Purinergic; D018047:Receptors, Purinergic P1; D018048:Receptors, Purinergic P2; D058476:Receptors, Purinergic P2X2