Pyrrole analogues of chloramphenicol. I. Synthesis and antibacterial activity of DL-threo-1-(1-methyl-4-nitropyrrole-2-yl)-2-dichloroacetamidopropane-1,3-diol.
The seven-stage synthesis of a pyrrole analogue of chloramphenicol [IX] was described. The compound exhibits a significant antibacterial activity, over the 12-50% range of the chloramphenicol activity.
Krajewska
D
D
Department of Organic Chemistry, Institute of Chemistry, Medical Academy, 2A Mickiewicza Str., 15-230 Białystok, Poland.
Dabrowska
M
M
Jakoniuk
P
P
Rózański
A
A
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002701:Chloramphenicol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
C420022:1-(1-methyl-4-nitropyrrol-2-yl)-2-dichloroacetamidopropane-1,3-diol; D000900:Anti-Bacterial Agents; D011758:Pyrroles; D002701:Chloramphenicol