title: Primary anaplastic large cell lymphoma of the lung: a clinicopathologic study of five patients.
abstract: Primary anaplastic large-cell lymphoma is a rare malignancy in the lung. Anaplastic large-cell lymphoma characteristically involves the lymph nodes or skin, with few reports from other sites. We studied the clinical and pathologic features of five cases of anaplastic large-cell lymphoma limited to the lungs. The patients were three women and two men aged 27 to 66 years (mean, 44.6 y) The tumors ranged in size from 1.1 to 5 cm. All patients were CD 30 (Ki-1) positive and CD 15 (LeuM-1) negative. Epithelial membrane antigen immunoreactivity was seen in two patients. Epstein-Barr virus was not detected by immunohistochemistry (four patients tested) or by polymerase chain reaction studies (three patients tested). The immunophenotypes were T cell (n = 3) and null (n = 2). Gene rearrangement studies supported the immunophenotypic findings. One patient who had underlying HIV infection died of infectious complications. One patient died at 6 months. Two patients developed recurrent disease and are alive after 42 and 51 months of follow-up. The remaining patient is alive at 8 years of follow-up without evidence of disease. ALCL can mimic metastatic or primary carcinoma and should be considered in the differential diagnosis of large cell neoplasms of the lung.
authors.affiliation: Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Rush
authors.forename: J A
authors.initials: JA
authors.lastname: Andriko
authors.forename: J K
authors.initials: JK
authors.lastname: Taubenberger
authors.forename: A M
authors.initials: AM
authors.lastname: Nelson
authors.forename: S L
authors.initials: SL
authors.lastname: Abbondanzo
authors.forename: W D
authors.initials: WD
authors.lastname: Travis
authors.forename: M N
authors.initials: MN
authors.lastname: Koss
mesh_terms: D000328:Adult; D000368:Aged; D017809:Fatal Outcome; D005260:Female; D015321:Gene Rearrangement; D015658:HIV Infections / Q000150:complications; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016019:Survival Analysis