Peroxidases.
The family of human peroxidases described includes myeloperoxidase, eosinophil peroxidase, uterine peroxidase, lactoperoxidase, salivary peroxidase, thyroid peroxidase and prostaglandin H1/2 synthases. The chemical identity of the peroxidase compound I and II oxidation states for the different peroxidases are compared. The identities of the distal and proximal amino acids of the catalytic site of each peroxidase are also compared. The gene characteristics and chromosomal location of the human peroxidase family have been tabulated and their molecular evolution discussed. Myeloperoxidase polymorphism and the mutations identified so far that affect myeloperoxidase activity and modulate their susceptibility to disease is described. The mechanisms for hypohalous and hypothiocyanate formation by the various peroxidases have been compared. The cellular function of the peroxidases and their hypohalites have been described as well as their inflammatory effects. The peroxidase catalysed cooxidation of drugs and xenobiotics that results in oxygen activation by redox cycling has been included. Low-density lipoprotein oxidation (initiation of atherosclerosis), chemical carcinogenesis, idiosyncratic drug reactions (e.g. agranulocytosis), liver necrosis or teratogenicity initiated by the cooxidation of endogenous substrates, plasma amino acids, drugs and xenobiotics catalysed by peroxidases or peroxidase containing cells have also been compared. Finally, peroxidase inhibitors currently in use for treating various diseases are described.
O'Brien
P J
PJ
Faculty of Pharmacy, University of Toronto, 19 Russell Street, Ont., M5S 2S2, Toronto, Canada. peter.obrien@utoronto.ca
D000818:Animals; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D006801:Humans; D008658:Inactivation, Metabolic; D008322:Mammals; D010544:Peroxidases / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D013379:Substrate Specificity; D015262:Xenobiotics / Q000493:pharmacokinetics*
D015262:Xenobiotics; D010544:Peroxidases