title: A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the clinical effectiveness of a bovine porous bone mineral used in combination with a porcine derived collagen membrane as a barrier in promoting periodontal regeneration in intrabony defects in humans.
  
  
  METHODS
  The study employed a split-mouth design. 22 paired intrabony defects were treated and surgically re-entered 6 months after treatment. Experimental sites were grafted with bovine porous bone mineral and received a collagen membrane for guided tissue regeneration. Control sites were treated with an open flap debridement.
  
  
  RESULTS
  Preoperative pocket depths, attachment levels and trans-operative bone measurements were similar for control and experimental sites. Post surgical measurements revealed a significantly greater reduction in pocket depth (differences of 1.89 +/- 0.31 mm on buccal 0.88 +/- 0.27 mm on lingual measurements) and more gain in clinical attachment (differences of 1.51 +/- 0.33 mm on buccal and 1.50 +/- 0.35 mm on lingual measurements) in experimental sites. Surgical reentry of the treated defects revealed a significantly greater amount of defect fill in favor of experimental sites (differences of 2.67 +/- 0.91 mm on buccal and 2.54 +/- 0.87 mm on lingual measurements).
  
  
  CONCLUSIONS
  The results of this study indicate that clinical resolution of intrabony defects can be achieved using a combination of bovine porous bone mineral and an absorbable, porcine derived collagen membrane when employing a technique based on the principles of guided tissue regeneration. The nature of the attachment between the newly regenerated tissue and the root surfaces needs to be evaluated histologically to confirm the presence of new attachment.
authors.affiliation: University of California, Los Angeles, School of Dentistry, 90095, USA. pauloc@dentnet.dent.ucla.edu
authors.forename: P M
authors.initials: PM
authors.lastname: Camargo
authors.forename: V
authors.initials: V
authors.lastname: Lekovic
authors.forename: M
authors.initials: M
authors.lastname: Weinlaender
authors.forename: M
authors.initials: M
authors.lastname: Nedic
authors.forename: N
authors.initials: N
authors.lastname: Vasilic
authors.forename: L E
authors.initials: LE
authors.lastname: Wolinsky
authors.forename: E B
authors.initials: EB
authors.lastname: Kenney
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D018786:Bone Substitutes; D002417:Cattle; D003094:Collagen; D012534:Dental Scaling; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008567:Membranes, Artificial; D008903:Minerals; D017622:Periodontal Attachment Loss / Q000601:surgery; D010514:Periodontal Pocket / Q000601:surgery; D012086:Reoperation; D016896:Treatment Outcome
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen