Resolution of childhood peanut allergy.
BACKGROUND
Peanut allergy creates great fear in many families because it is one of the leading causes of fatal and near-fatal food-induced allergies. Earlier reports suggested that peanut allergy was life-long, but a recent study described resolution of peanut allergy in some children.


OBJECTIVE
Tolerance to peanut allergy in childhood was studied. Examination of the natural history of childhood peanut allergy was explored.


METHODS
A retrospective review of all children with peanut allergy seen at the Children's Hospital of Philadelphia in a 3-year period (n = 293). Children with histories of peanut allergy were challenged at the mean age [3.8 years; range 1.5 to 8 year] which was 1.8 years [range: 0.5 to 6.8 years], following their last known clinical reaction. Food allergy or tolerance was confirmed by open challenges.


RESULTS
Thirty-three patients with histories of peanut allergy and a positive skin test to peanut underwent oral challenges. Not one patient (n = 5) with a history of peanut anaphylaxis developed tolerance to peanuts. In comparison, 9 of 17 patients with history of urticaria upon ingestion to peanuts developed tolerance. Also, 4 of 10 patients with flaring of their atopic dermatitis upon ingestion to peanuts developed tolerance. The 14 patients with a negative challenge to peanut had a significantly smaller wheal and flare reaction than the 19 patients with positive challenges. Tolerance to peanut was documented by a positive challenge reverting to a negative challenge in one patient. Oral challenge of 13 additional patients with positive skin tests and histories of only refusing to eat peanut resulted in 5 (39%) positive challenges.


CONCLUSIONS
A selected group of peanut-allergic children, who do not have a history anaphylaxis to peanut, may develop tolerance to peanuts.
Spergel
J M
JM
Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, Pennsylvania 19104, USA.
Beausoleil
J L
JL
Pawlowski
N A
NA
D010367:Arachis / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005512:Food Hypersensitivity / Q000150:complications / Q000209:etiology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000209:etiology; D007108:Immune Tolerance / Q000502:physiology; D007223:Infant; D012189:Retrospective Studies; D012882:Skin Tests