title: Versatile, diastereoselective additions of silyl ketene acetals, allyl tributylstannane, and Me(3)SiCN to N-acyl pyrazolines: asymmetric synthesis of densely functionalized pyrazolidines
abstract: We report the diastereoselective addition of a wide range of nucleophiles to chiral pyrazolines to provide facile access to a range of useful densely functionalized building blocks for asymmetric synthesis. Coupled with the asymmetric cycloaddition reaction of Me(3)SiCHN(2) to chiral acrylates, access to these chiral heterocycles is considerably expanded.
authors.affiliation: Laboratorium fur Organische Chemie, ETH-Zentrum, Universitatrasse 16, CH-8092 Zurich, Switzerland.
authors.initials: FM
authors.lastname: Guerra
authors.initials: MR
authors.lastname: Mish
authors.initials: EM
authors.lastname: Carreira