Nutrition in inflammatory bowel disease.
Recent developments concerning nutritional complications of inflammatory bowel disease include a better understanding of disease-associated anorexia and increasing recognition of the interaction of nutrition and cytokines in the pathogenesis of growth impairment of children. Decreased bone mineral density is a multifactorial complication and an increased focus of research. Enteral nutrition continues to play an important role in the therapy of Crohn's disease. The mechanisms whereby specific nutrients, such as n-3 fatty acids, antioxidants, and butyrate, ameliorate inflammation are being elucidated in in-vitro studies, but beneficial effects have yet to be translated into the clinical sphere.
Ling
S C
SC
Royal Hospital for Sick Children, Yorkhill, Glasgow, UK. lingsimon@hotmail.com
Griffiths
A M
AM
D000855:Anorexia / Q000150:complications; D000975:Antioxidants / Q000627:therapeutic use; D015519:Bone Density; D002087:Butyrates / Q000627:therapeutic use; D003424:Crohn Disease / Q000178:diet therapy; D016207:Cytokines / Q000097:blood / Q000276:immunology; D004750:Enteral Nutrition; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use; D005973:Glutamine / Q000627:therapeutic use; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000178:diet therapy* / Q000276:immunology; D009748:Nutrition Disorders / Q000150:complications / Q000178:diet therapy* / Q000209:etiology; D009747:Nutritional Physiological Phenomena; D010024:Osteoporosis / Q000209:etiology
D000975:Antioxidants; D002087:Butyrates; D016207:Cytokines; D015525:Fatty Acids, Omega-3; D005973:Glutamine