title: Differential regional cerebral uptake of (18)F-fluoro-2-deoxy-D-glucose in Alzheimer's disease and frontotemporal dementia at initial diagnosis.
abstract: In this paper, the cerebral uptake of (18)F-fluoro-2-deoxy-D-glucose (FDG) was studied in a relatively small group of patients suffering from either clinically diagnosed Alzheimer's disease (AD) or frontotemporal dementia during the initial differential diagnostic workup. The image analysis was done visually and semiquantitatively using three different reference regions. Visual analysis confirmed earlier literature findings on the distribution of decreased FDG uptake and demonstrated prevalent asymmetric patterns in both groups. Only semiquantitative analysis using the sensorimotor cortex as a reference region confirmed the visual findings. Moreover, there were no differences in medial temporal lobe activities between both groups, and there was no correlation of medial temporal lobe activity with dementia severity. In the AD group, a correlation of parietal FDG uptake with MMSE scores was found.
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium. patrick.santens@rug.ac.be
authors.forename: P
authors.initials: P
authors.lastname: Santens
authors.forename: J
authors.initials: J
authors.lastname: De Bleecker
authors.forename: P
authors.initials: P
authors.lastname: Goethals
authors.forename: K
authors.initials: K
authors.lastname: Strijckmans
authors.forename: I
authors.initials: I
authors.lastname: Lemahieu
authors.forename: G
authors.initials: G
authors.lastname: Slegers
authors.forename: R
authors.initials: R
authors.lastname: Dierckx
authors.forename: J
authors.initials: J
authors.lastname: De Reuck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D003704:Dementia / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18