title: Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8594, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: R B
authors.initials: RB
authors.lastname: Gaynor
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000235:genetics; D001172:Arthritis, Rheumatoid / Q000209:etiology; D001249:Asthma / Q000209:etiology; D002455:Cell Division / Q000235:genetics; D018925:Chemokines / Q000096:biosynthesis / Q000235:genetics; D051546:Cyclooxygenase 2; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D005938:Glucocorticoids / Q000627:therapeutic use; D051550:I-kappa B Kinase; D020672:I-kappa B Proteins / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000209:etiology; D007527:Isoenzymes / Q000096:biosynthesis / Q000235:genetics; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis / Q000235:genetics; D052247:Nitric Oxide Synthase Type II; D010766:Phosphorylation; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D018925:Chemokines; D016207:Cytokines; D005938:Glucocorticoids; D020672:I-kappa B Proteins; D007166:Immunosuppressive Agents; D007527:Isoenzymes; D016328:NF-kappa B; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D017346:Protein Serine-Threonine Kinases; D051550:I-kappa B Kinase