title: A multicentre study on eradication of Helicobacter pylori using four 1-week triple therapies in China.
abstract: BACKGROUND
  Short-term proton pump inhibitor-based triple therapies for the eradication of Helicobacter pylori are used widely. The eradication rates vary greatly from country to country and from region to region.
  
  
  OBJECTIVE
  To assess the efficacy at eradicating H. pylori of 1-week regimens containing three medications: omeprazole (O) or colloidal bismuth subcitrate (B), furazolidone (F) or metronidazole (M), and amoxicillin (A) or clarithromycin (C).
  
  
  METHODS
  A multicentre study involving 20 hospitals in different regions of China. A total of 892 patients with H. pylori-positive non-ulcer dyspepsia or healed duodenal ulcer confirmed by endoscopy were recruited to receive, randomly, one of four regimens: OMC, OFC, OFA, and BFC, b.d. for 7 days. 13C-urea breath test was performed 4-8 weeks after completion of treatment.
  
  
  RESULTS
  The eradication rates with per protocol/intention-to-treat analyses were: OMC (n=217/219) 66%/65%; OFC (n=227/229) 69%/69%; OFA (n=223/225) 87%/86%; and BFC (n=214/219) 80%/78%. The eradication rate (per protocol analysis) in duodenal ulcer (79%) was higher than that in non-ulcer dyspepsia (73%, P=0.033). Patient compliance was good. The adverse events of the four regimens were mild, and mainly gastrointestinal.
  
  
  CONCLUSIONS
  The omeprazole, furazolidine and amoxicillin regimen achieves a high H. pylori eradication rate in different geographical regions of China.
authors.affiliation: Shanghai Institute of Digestive Disease, Shanghai Second Medical University Renji Hospital, Shanghai, China. sdxiao@guomai.sh.cn
authors.forename: S D
authors.initials: SD
authors.lastname: Xiao
authors.forename: W Z
authors.initials: WZ
authors.lastname: Liu
authors.forename: P J
authors.initials: PJ
authors.lastname: Hu
authors.forename: Q
authors.initials: Q
authors.lastname: Ouyang
authors.forename: J L
authors.initials: JL
authors.lastname: Wang
authors.forename: L Y
authors.initials: LY
authors.lastname: Zhou
authors.forename: N N
authors.initials: NN
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000008:administration & dosage; D001944:Breath Tests; D017291:Clarithromycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D005664:Furazolidone / Q000008:administration & dosage; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage; D011446:Prospective Studies
chemical_list: D008795:Metronidazole; D005664:Furazolidone; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole