title: Tc-99m HDP bone scan showing bone changes in a case of tuberous sclerosis or Bourneville's disease.
abstract: Whole-body Tc-99m HDP scintigraphy was performed in a 25-year-old woman with known tuberous sclerosis. The scintigraphic pattern showed multiple foci of abnormal activity over the hands, phalanges, feet, tibias, fibulas, ulnas, and radii, where radiographs showed periosteal apposition, irregular cortical thickening, and cystlike lesions on the phalanges. The spine, pelvis, and ribs showed heterogeneous tracer uptake where radiographs showed patchy areas of increased bone density. This radiographic pattern is characteristic of osseous tuberous sclerosis. Although previous reports suggested the opposite conclusion, this observation indicates that an abnormal result of bone scintiscan can be observed in osseous tuberous sclerosis.
authors.affiliation: Center of Nuclear Medicine, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Jonard
authors.forename: M
authors.initials: M
authors.lastname: Lonneux
authors.forename: B
authors.initials: B
authors.lastname: Boland
authors.forename: J
authors.initials: J
authors.lastname: Malghem
authors.forename: F
authors.initials: F
authors.lastname: Jamar
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives*; D014402:Tuberous Sclerosis / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate