title: [Antiinflammatory capacity of topical ketorolac in experimental model of ocular inflammation].
abstract: OBJECTIVE
  We studied the antiinflammatory effect of topical Ketorolac-Tromethamine on a model of endotoxin-induced uveitis in albino rabbits.
  
  
  METHODS
  Endotoxin-induced uveitis was produced by intravitreal injection in the right eye of 10 ng lipopolysaccharide (LPS) A Salmonella typhimurium endotoxin in 5 microl saline solution. We have used 60 animals (5 groups of 12 animals each). Control group (G-I) was injected with saline (5 microl); endotoxin group (G-II) was injected with 10 ng of endotoxin; groups III, IV and V were injected with the same amount of endotoxin and treated with topical ketorolac-tromethamine every 6, 4 and 2 hours respectively. The animals were sacrificed 24 hours after endotoxin administration. We determined the ocular clinical signs and inflammatory cells and protein concentration in the aqueous humor.
  
  
  RESULTS
  In all the groups treated with Ketorolac-Tromethamine we observed a significant reduction (p<0.05) in all parameters studied when compared with those of the endotoxin group (G-II).
  
  
  CONCLUSIONS
  Topical Ketorolac-Tromethamine has demonstrated a significant reduction of endotoxin-induced-uveitis inflammation.
authors.affiliation: Servicio de Oftalmología, Hospital Miguel Servet, Po. Isabel la Católica, 1-3, 50009 Zaragoza, Spain.
authors.forename: O R
authors.initials: OR
authors.lastname: Moreno
authors.forename: R C
authors.initials: RC
authors.lastname: Andrés
authors.forename: L P
authors.initials: LP
authors.lastname: Júlvez
authors.forename: V P
authors.initials: VP
authors.lastname: Llorens
authors.forename: D
authors.initials: D
authors.lastname: Marín Del Tiempo
authors.forename: E F
authors.initials: EF
authors.lastname: Novella
authors.forename: C
authors.initials: C
authors.lastname: Torrón
authors.forename: F M
authors.initials: FM
authors.lastname: Honrubia
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D020910:Ketorolac / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D014605:Uveitis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D020910:Ketorolac