title: Radiosynthesis of [123I]betaCIT, a selective ligand for the study of the dopaminergic and serotoninergic systems in human brain.
abstract: The procedure previously reported for the radiosynthesis of [123I]betaCIT was modified in order to improve both radiochemical yield and purity of betaCIT (2beta-carbomethoxy-3beta(4-iodophenyl) tropane) to be injected for SPECT (Single Photon Emission Computed Tomography) analysis imaging. The overall procedure, involving a HPLC purification step, results in quite good and reproducible yields of a highly purified tracer.
authors.affiliation: CNR-INB, University of Milano-Bicocca, Scientific Institute H San Raffaele, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Carpinelli
authors.forename: M
authors.initials: M
authors.lastname: Matarrese
authors.forename: R M
authors.initials: RM
authors.lastname: Moresco
authors.forename: P
authors.initials: P
authors.lastname: Simonelli
authors.forename: S
authors.initials: S
authors.lastname: Todde
authors.forename: F
authors.initials: F
authors.lastname: Magni
authors.forename: M
authors.initials: M
authors.lastname: Galli Kienle
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D012701:Serotonin / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D007457:Iodine Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals; D012701:Serotonin; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine; D004298:Dopamine