title: Comparison of efficacy and side effects of epidural tramadol and morphine in patients undergoing laminectomy: a repeated dose study.
abstract: Tramadol acts through multiple mechanisms and has a low risk of post operative respiratory depression. We compared the efficacy of epidural tramadol with that of morphine for postoperative analgesia in these patients. The demographic data and the summed pain intensity difference scores (SPID) were similar in both the groups. The time to first supplementary dose was significantly shorter in the tramadol group compared to the morphine group (p<0.05). No patient in either group suffered respiratory depression.
authors.affiliation: Department of Anaesthesia, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
authors.forename: L N
authors.initials: LN
authors.lastname: Yaddanapudi
authors.forename: J
authors.initials: J
authors.lastname: Wig
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: M K
authors.initials: MK
authors.lastname: Tewari
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000601:surgery; D007796:Laminectomy; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects*; D010149:Postoperative Pain / Q000188:drug therapy; D014147:Tramadol / Q000008:administration & dosage* / Q000009:adverse effects*
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol; D009020:Morphine