title: Early changes in quasispecies repertoire in HIV-infected infants: correlation with disease progression.
abstract: The evolution of HIV-1 quasispecies in patients during the first year of life was investigated in 10 vertically infected infants, using heteroduplex analysis of the V3-V5 region of env. Four subjects, who showed little viral evolution during the period of the study, had rapid progression of disease and early loss of CD4(+) cells. The remaining six subjects, who were slow progressors, evolved new viral variants within 6 months, and in one case by 1 month of age. Of the four patients who were PCR positive at birth, one was infected with multiple HIV-1 variants. These results show that in HIV-infected children, multiple variants may initiate infection and early quasispecies diversification is associated with a favorable clinical outcome.
authors.affiliation: Department of Pediatric Infectious Diseases, New York University Medical Center, New York City, New York 10016, USA. shaffiq.essajee@med.nyu.edu
authors.forename: S M
authors.initials: SM
authors.lastname: Essajee
authors.forename: H
authors.initials: H
authors.lastname: Pollack
authors.forename: G
authors.initials: G
authors.lastname: Rochford
authors.forename: I
authors.initials: I
authors.lastname: Oransky
authors.forename: K
authors.initials: K
authors.lastname: Krasinski
authors.forename: W
authors.initials: W
authors.lastname: Borkowsky
mesh_terms: D018450:Disease Progression; D019143:Evolution, Molecular; D015686:Gene Products, env / Q000235:genetics; D015752:Genes, env; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000503:physiopathology* / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics*; D020180:Heteroduplex Analysis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010446:Peptide Fragments / Q000235:genetics; D016133:Polymerase Chain Reaction
chemical_list: D015686:Gene Products, env; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments