[Effect of Ruboxyl (nitroxyl derivative of daunorubicin) on hepatic  metastases of colorectal carcinoma].
Inhibition by ruboxyl, a nitroxyl derivative of daunorubicin, source preparation and 5-fluorouracil was compared in metastases of experimental colorectal carcinoma to murine liver. The indices of metastasis inhibition were 84.43 and 70%, respectively. In rats receiving the drugs by continuous intravenous infusion for 7 days, the number of metastases was reduced (ruboxyl--1.0 +/- 1.4; 5-fluorouracil 3.2 +/- 1.3.
Konovalova
N P
NP
Institute of Problems of Chemical Physics, Russian Academy of Sciences, Moscow.
Volkova
L M
LM
Codacci-Pisanelli
D
D
Seminara
P
P
Franchi
F
F
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology*; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D015179:Colorectal Neoplasms / Q000473:pathology*; D003630:Daunorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005472:Fluorouracil / Q000494:pharmacology; D007262:Infusions, Intravenous; D008113:Liver Neoplasms / Q000188:drug therapy / Q000517:prevention & control* / Q000556:secondary; D051379:Mice; D051381:Rats
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; C042480:ruboxyl; D005472:Fluorouracil; D003630:Daunorubicin