Treatment of Adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL).
The German Multicenter Study Group for Adult Acute Lymphoblastic leukemia (GMALL) has conducted 5 consecutive trials with more than 3000 patients since 1981. This article provides an overview on aims, treatment concepts, and results of these studies. It includes brief summaries on the development of prognostic models within the GMALL group and on approaches for prophylaxis of CNS relapse, and it summarizes specific treatment concepts for mature B-lineage acute lymphocytic leukemia.
Gökbuget
N
N
German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia, Frankfurt, Germany.
Hoelzer
D
D
Arnold
R
R
Böhme
A
A
Bartram
C R
CR
Freund
M
M
Ganser
A
A
Kneba
M
M
Langer
W
W
Lipp
T
T
Ludwig
W D
WD
Maschmeyer
G
G
Rieder
H
H
Thiel
E
E
Weiss
A
A
Messerer
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000145:classification / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D016543:Central Nervous System Neoplasms / Q000517:prevention & control; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005858:Germany / Q000453:epidemiology; D006801:Humans; D016130:Immunophenotyping; D007278:Injections, Spinal; D016393:Lymphoma, B-Cell / Q000188:drug therapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D008962:Models, Theoretical; D015337:Multicenter Studies as Topic; D010865:Pilot Projects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D012306:Risk; D015996:Survival Rate; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome
D008727:Methotrexate