Evaluation of a fully automated assay to measure C-telopeptide of type I collagen in serum.
The measurement of the degradation product of the C-telopeptide of type I collagen in serum (s-betaCTX) has been evaluated in the form of an automated chemiluminometric assay. The between-day coefficients of variation ranged between 2.6 and 6.0% over the concentration range 0.12 to 3.25 microg/l. The s-betaCTX value correlated well with alternative serum C-telopeptide (r = 0.983) and urine deoxypyridinoline (r = 0.729) measurements. A significant inverse correlation was found between the s-betaCTX measurement and creatinine clearance in patients with renal disease.
Pagani
F
F
Laboratorio Analisi Chimico Cliniche 1, Azienda Ospedaliera Spedali Civili, Brescia, Italy.
Bonetti
G
G
Stefini
F
F
Panteghini
M
M
D000328:Adult; D001331:Automation; D015415:Biomarkers; D001862:Bone Resorption; D016022:Case-Control Studies; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood; D010455:Peptides / Q000097:blood*; D017697:Premenopause; D012680:Sensitivity and Specificity
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen