Influence of bovine antiserum (Bo-Bac 2X) injection on colostral immunoglobulin G absorption in neonatal dairy calves.
On the background of positive survival data from farms in Mississippi, treating calves with antiserum injection in addition to normal colostrum administration, the objective of the present study was to evaluate the influence of a single subcutaneously administered bovine antiserum injection (0.031 g of IgG/kg of body weight) and pooled colostrum administration on efficiency of Ig absorption and on 24-h plasma IgG concentration in neonatal bull calves. Twenty-nine male dairy calves (21 Holsteins and 8 Jerseys) were assigned randomly at parturition to receive one of four treatments: 1) colostrum (n = 9), 2) colostrum and bovine antiserum injection (n = 7), 3) milk replacer (n = 5), or 4) milk replacer and bovine antiserum injection (n = 8). At birth, calves either did or did not receive an injection of bovine antiserum and were fed pooled colostrum or milk replacer (Holsteins, 3.8 L; Jerseys, 1.9 L) via an esophageal feeder. Blood was collected immediately before administration of the colostrum or milk replacer, then again at 24 and 48 h postpartum. Immunoglobulin G concentrations of colostrum, milk replacer, antiserum, and plasma were monitored by single radial immunodiffusion. Colostrum administration and injection of bovine antiserum each increased plasma Ig concentration at 24 h posttreatment. In addition, antiserum injection increased the apparent efficiency of absorption of colostral Ig by 42% over that for calves fed colostrum alone. The increase in plasma IgG for antiserum-treated calves exceeded the total amount of IgG administered in the antiserum injection; hence, this increase appeared to be the result of an increase in total absorption of colostral IgG, or possibly antiserum injection somehow triggered active synthesis of IgG. Injection of antiserum might possibly serve as a beneficial adjunct to a colostrum management program by enhancing the acquisition of passive immunity from colostral sources.
Pedersen
R E
RE
Department of Animal and Dairy Sciences, Mississippi State University, MS 39762, USA.
Paulrud
C O
CO
Tucker
W B
WB
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology / Q000378:metabolism*; D002417:Cattle / Q000276:immunology / Q000378:metabolism*; D003126:Colostrum / Q000276:immunology* / Q000378:metabolism; D007106:Immune Sera / Q000008:administration & dosage / Q000494:pharmacology*; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism*; D007279:Injections, Subcutaneous / Q000662:veterinary; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D013534:Survival; D015430:Weight Gain / Q000276:immunology
D007106:Immune Sera; D007074:Immunoglobulin G