Differences in DNA packaging genes and sensitivity to benzimidazole ribonucleosides between human cytomegalovirus strains AD169 and Towne.
The AD169 strain of human cytomegalovirus was approximately twofold more sensitive to polyhalogenated benzimidazole ribonucleosides than Towne strain. Sequence differences between the two strains have been identified in genes UL51, UL52, UL56, UL77, UL89 and UL104. Because these genes are involved in cleavage and packaging of viral DNA and the benzimidazole ribonucleosides inhibit this process, these sequence differences may be involved in the difference in drug sensitivity.
Krosky
P M
PM
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor 48109-1078, USA.
Ptak
R G
RG
Underwood
M R
MR
Biron
K K
KK
Townsend
L B
LB
Drach
J C
JC
D001562:Benzimidazoles / Q000737:chemistry*; D003587:Cytomegalovirus / Q000235:genetics / Q000502:physiology*; D005814:Genes, Viral; D008969:Molecular Sequence Data; D012263:Ribonucleosides / Q000737:chemistry / Q000494:pharmacology*; D019065:Virus Assembly / Q000235:genetics*
D001562:Benzimidazoles; D012263:Ribonucleosides