title: Three new cytochalasins produced by an endophytic fungus in the genus Rhinocladiella.
abstract: Three new cytotoxic cytochalasins (1-3) and the previously reported cytochalasin E (4) were isolated from a culture of the endophytic fungus Rhinocladiella sp. using bioassay-guided fractionation. Extensive NMR and HRCIMS experiments identified these new compounds as 22-oxa-[12]-cytochalasins.
authors.affiliation: Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Wagenaar
authors.forename: J
authors.initials: J
authors.lastname: Corwin
authors.forename: G
authors.initials: G
authors.lastname: Strobel
authors.forename: J
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D003572:Cytochalasins / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D003572:Cytochalasins