title: Self-sterilizing and self-cleaning of silicone catheters coated with TiO(2) photocatalyst thin films: a preclinical work.
abstract: TiO(2) photocatalysts were successfully coated on silicone catheters or medical tubes by pretreatment of the silicone surface with a sulfuric acid solution (5 M) for 3 h. The TiO(2) film adhered to the silicone substrate strongly against tensile and bending stresses. On the TiO(2)-coated silicone-catheters under UV illumination, both the bleaching of methylene blue dye and the photocatalytic bactericidal effect on Escherichia coli (E. coli) cells were confirmed. Thus, this type of catheter can be sterilized and cleaned simply by irradiation with low-intensity UV light and can, therefore, be useful in the protection from catheter-related bacterial infections.
authors.affiliation: Department of Applied Chemistry, School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohko
authors.forename: Y
authors.initials: Y
authors.lastname: Utsumi
authors.forename: C
authors.initials: C
authors.lastname: Niwa
authors.forename: T
authors.initials: T
authors.lastname: Tatsuma
authors.forename: K
authors.initials: K
authors.lastname: Kobayakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: A
authors.initials: A
authors.lastname: Fujishima
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000528:radiation effects; D004866:Equipment Contamination / Q000517:prevention & control*; D004867:Equipment Design; D004926:Escherichia coli / Q000528:radiation effects; D017053:Infection Control / Q000379:methods*; D008422:Materials Testing; D008751:Methylene Blue / Q000528:radiation effects; D008855:Microscopy, Electron, Scanning; D010084:Oxidation-Reduction; D010777:Photochemistry; D018583:Pliability; D017382:Reactive Oxygen Species; D012828:Silicones / Q000737:chemistry*; D013242:Sterilization / Q000379:methods*; D013464:Sulfuric Acids / Q000494:pharmacology; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D020099:Coated Materials, Biocompatible; D017382:Reactive Oxygen Species; D012828:Silicones; D013464:Sulfuric Acids; C009495:titanium dioxide; D014025:Titanium; C033158:sulfuric acid; D008751:Methylene Blue