title: Glycopeptide-resistant Enterococcus faecium infections in paediatric liver transplant recipients: safety and clinical efficacy of quinupristin/dalfopristin.
abstract: We describe our experience of quinupristin/dalfopristin for glycopeptide-resistant Enterococcus faecium (GREF) infections in 19 paediatric liver transplant recipients. The median patient age was 2 years and all were receiving immunosuppressive regimens. Quinupristin/dalfopristin was well tolerated and complete resolution of infection was seen in 74% of patients. Side-effects included reversible elevation of serum alkaline phosphatase, skin rash, itching, diarrhoea and vomiting, but therapy was not withdrawn from any patient. Quinupristin/dalfopristin appears safe and efficacious in critically ill immunocompromised children with renal or hepatic impairment.
authors.affiliation: Dulwich Public Health Laboratory & Medical Microbiology, King's College Hospital, London, SE5 9RS, UK.
authors.forename: A
authors.initials: A
authors.lastname: Verma
authors.forename: A
authors.initials: A
authors.lastname: Dhawan
authors.forename: J
authors.initials: J
authors.lastname: Philpott-Howard
authors.forename: M
authors.initials: M
authors.lastname: Rela
authors.forename: N
authors.initials: N
authors.lastname: Heaton
authors.forename: G M
authors.initials: GM
authors.lastname: Vergani
authors.forename: J
authors.initials: J
authors.lastname: Wade
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000009:adverse effects / Q000627:therapeutic use*; D016984:Enterococcus faecium / Q000187:drug effects; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D007231:Infant, Newborn; D016031:Liver Transplantation; D008297:Male; D016896:Treatment Outcome; D014769:Virginiamycin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin