Vear, a novel Golgi-associated protein, is preferentially expressed in type I cells in skeletal muscle.
Vear is a novel Golgi-associated protein with a domain structure characteristic of many vesicular transport-associated proteins. It has been suggested that Vear is involved in vesicle transport through trans-Golgi. In this study, we have determined the localization of Vear in skeletal muscle. The staining for Vear in normal human muscle revealed a distribution pattern similar to that of type I fibers. We conclude that Vear is preferentially expressed in type I fibers in human muscle, presumably indicative of a specific function that remains to be identified.
Poussu
A M
AM
Department of Pathology, University of Oulu, PO Box 5000 (Aapistie 5), Oulu FIN-90410, Finland.
Thompson
P H
PH
Mäkinen
M J
MJ
Lehto
V P
VP
D033942:Adaptor Proteins, Vesicular Transport; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D002352:Carrier Proteins; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008856:Microscopy, Fluorescence; D018657:Muscle Fibers, Slow-Twitch / Q000166:cytology / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D009928:Organ Specificity; D014176:Protein Biosynthesis
D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; C405944:GGA2 protein, human; D009243:NAD; D000251:Adenosine Triphosphatases