Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection.
Human immunodeficiency virus (HIV) infection is associated with a progressive dementia, in addition to motor and behavioural deficits. Cognitive deterioration and motor impairments have been observed also in simian immunodeficiency virus (SIV)-infected monkeys, an animal model for HIV infection. We found recently that choline acetyltransferase activity is markedly reduced in brains of SIV-infected monkeys. We report now that selegiline, completely restores the reduced choline acetyltransferase activity which encourages for a meaningful anti-dementia therapeutic strategy.
Koutsilieri
E
E
Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Füchsleinstr. 15, 97080, Würzburg, Germany. eleni.koutsilieri@gmx.de  
Scheller
C
C
Sopper
S
S
Götz
M E
ME
Gerlach
M
M
Meulen
V
V
Riederer
P
P
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology; D008253:Macaca mulatta; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D011699:Putamen / Q000187:drug effects / Q000201:enzymology; D012642:Selegiline / Q000494:pharmacology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000201:enzymology* / Q000821:virology; D015302:Simian Immunodeficiency Virus
D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D002795:Choline O-Acetyltransferase