title: Delayed expression of somatostatin mRNA in GDNFs-dependent rat sensory neurons during postnatal development.
abstract: Gene expression of somatostatin (SST) and preprotachykinin A (PPTA) in lumbar DRG neurons of postnatal developing rats was examined by in situ hybridization. SST mRNA signals were not seen in DRG neurons until postnatal day 1 to 7, and were detected in about 10% of DRG neurons of 2- and 8-week-old rats. The positive neurons expressed c-ret mRNA in 8-week-old rats. On the other hand, PPTA mRNA signals were constantly seen in about 30% of DRG neurons. This study demonstrates the differential expression patterns of SST and PPTA mRNAs in DRG neurons of developing rats.
authors.affiliation: Department of Physiology, Kansai College of Oriental Medicine, 2-11-1 Wakaba, Kumatori, Sennan, 590-0433, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kashiba
authors.forename: E
authors.initials: E
authors.lastname: Senba
mesh_terms: D000818:Animals; D029721:Drosophila Proteins; D005727:Ganglia, Spinal / Q000166:cytology / Q000254:growth & development*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008297:Male; D009475:Neurons, Afferent / Q000166:cytology / Q000502:physiology*; D011498:Protein Precursors / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051096:Proto-Oncogene Proteins c-ret; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D013004:Somatostatin / Q000235:genetics*; D015320:Tachykinins / Q000235:genetics
chemical_list: D029721:Drosophila Proteins; D011498:Protein Precursors; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D015320:Tachykinins; C044206:preprotachykinin; D013004:Somatostatin; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila; C495001:Ret protein, rat