title: Mode of action of plasmolysed yeast on lymphocytes under microgravity stress.
abstract: A newly developed device to simulate microgravity for space biological investigations under laboratory conditions allowed us to apply a reproducible environmental stress on immunologically active cells. Cell proliferation, soluble IL-2 receptor in the culture supernatant, lymphocyte surface activation markers like CD25 (IL-2R), CD69 and HLA-Dr were the endpoints measured. Untreated donor lymphocyte reactions under microgravity were compared to the same cells treated with an immunomodulator from herbal plasmolysed yeast (Bio-Strath Food Supplement). The main finding is the enhancement of the proliferation inhibition under microgravitational stress by the herbal plasmolysed yeast.
authors.affiliation: PHOENIX-ANAWA, Wangen.
authors.forename: P W
authors.initials: PW
authors.lastname: Joller
authors.forename: M
authors.initials: M
authors.lastname: Schwarzenberg
authors.forename: A A
authors.initials: AA
authors.lastname: Cogoli
mesh_terms: D000276:Adjuvants, Immunologic; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D018474:Weightlessness Simulation; D015002:Yeast, Dried / Q000276:immunology* / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; C005065:Bio-Strath; D003208:Concanavalin A