Effects of angiotensin II on proliferative activity of epitheliocytes and smooth muscle cells of the tracheobronchial system in newborn albino rats.
Angiotensin II was injected intraperitoneally in a dose of 5x10(-8) mol/kg to newborn rats from the 2nd to 6th day of life. Autoradiography with 3H-thymidine showed that angiotensin II stimulated DNA synthesis in epitheliocytes and smooth muscle cells of the trachea and large (cartilaginous) and small (noncartilaginous) bronchi, intensified lipid peroxidation, and activated the antioxidant defense system in the lungs.
Lebed'ko
O A
OA
Institute of Maternity and Child Welfare, Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Khabarovsk.
Timoshin
S S
SS
Bespalova
N N
NN
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001980:Bronchi / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D014132:Trachea / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D000804:Angiotensin II