Statistical optimization of a sustained-release matrix tablet of lobenzarit disodium.
The statistical optimization of sustained-release matrix tablets of lobenzarit disodium salt (LDS) was performed using the central composite experiment design 2(3) for three independent variables: the amount of polymer (Eudragit RS-PO) AP, the total volume of granulation solvent VS, and the amount of filler (microcrystalline cellulose) CE. The t90% was selected as the response variable. The response surfaces were performed from a statistical mathematical model. The optimal formulation was obtained for the variables (AP = 15 mg, VS = 60 microliters, and CE = 0).
Boza
A
A
Department of Chemical Synthesis, Center of Pharmaceutical Chemistry, Havana, Cuba.
De la Cruz
Y
Y
Jordán
G
G
Jáuregui-Haza
U
U
Alemán
A
A
Caraballo
I
I
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002482:Cellulose / Q000737:chemistry; D003692:Delayed-Action Preparations; D006801:Humans; D008962:Models, Theoretical; D011108:Polymers; D012997:Solvents; D013607:Tablets; D062367:ortho-Aminobenzoates / Q000008:administration & dosage* / Q000493:pharmacokinetics
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011108:Polymers; D012997:Solvents; D013607:Tablets; D062367:ortho-Aminobenzoates; D002482:Cellulose; C015735:lobenzarit