title: [Intravenously administered gamma-globulins in reactive hemaphagocytic syndrome. Multicenter study to assess their importance, by the immunoglobulins group of experts of CEDIT of the AP-HP].
abstract: Reactive hemophagocytic syndrome is characterized by systemic proliferation and activation of benign hemophagocytic cells of the monocyte-macrophage lineage. Treatment should be directed to the etiology, but successful treatment with high-dose gamma-globulin has been reported, especially in viral-associated hemophagocytic syndrome. We report 17 patients, of which 9 had infection-associated hemophagocytic syndrome, all treated with high-dose gamma-globulin. High-dose gamma-globulins appear to be more effective in infection-associated hemophagocytic syndrome, with a mean dose of 1.6gm/kg for one or two cycles. A multicentric randomized study is required to evaluate high-dose gamma-globulin in the treatment of reactive hemophagocytic syndrome.
authors.affiliation: Service de Médecine Interne, Hôpital Avicenne, 125, rue de Stalingrad, 93009 Bobigny.
authors.forename: C
authors.initials: C
authors.lastname: Larroche
authors.forename: F
authors.initials: F
authors.lastname: Bruneel
authors.forename: M H
authors.initials: MH
authors.lastname: André
authors.forename: B
authors.initials: B
authors.lastname: Bader-Meunier
authors.forename: A
authors.initials: A
authors.lastname: Baruchel
authors.forename: B
authors.initials: B
authors.lastname: Tribout
authors.forename: T
authors.initials: T
authors.lastname: Genereau
authors.forename: P
authors.initials: P
authors.lastname: Zunic
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002675:Child, Preschool; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007111:Immunity, Cellular; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D016756:Immunoglobulins, Intravenous