Biomarkers of oxidative stress: an analytical approach.
Oxidative stress is implicated in many pathological processes and results from a disruption of the prooxidant/antioxidant balance. This review will focus on noninvasive biomarkers of radical-induced damage in biological fluids and particularly in blood. Special attention will be addressed to new analytical methods for the measurement of radical-mediated alterations in the integrity of lipids, proteins and DNA.
Thérond
P
P
Department of Biochemistry, Pharmacology and Toxicologie, Versailles Hospital, Le Chesnay, France.
Bonnefont-Rousselot
D
D
Davit-Spraul
A
A
Conti
M
M
Legrand
A
A
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D004247:DNA / Q000032:analysis / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D011506:Proteins / Q000032:analysis / Q000378:metabolism; D012680:Sensitivity and Specificity
D000975:Antioxidants; D015415:Biomarkers; D008055:Lipids; D011506:Proteins; D004247:DNA