title: Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor.
abstract: Three new 2-phenyl-benzofurans, ebenfuran I, ebenfuran II, and ebenfuran III, were isolated from Onobrychis ebenoides. Their structures were elucidated on the basis of chemical and spectral data as 2-(2,4-dihydroxyphenyl)-5-hydroxy-6-methoxy-benzofuran (1), 2-(2,4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-methoxy-benzofuran (2), and 2-(2, 4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-methoxy-5-(3-methyl-buten- 2-y l)-benzofuran (3). The affinity of these compounds for the estrogen receptor was studied using a receptor-binding assay.
authors.affiliation: Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens, Panepistimiopolis, Zografou, GR-15771, Athens, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Halabalaki
authors.forename: N
authors.initials: N
authors.lastname: Aligiannis
authors.forename: Z
authors.initials: Z
authors.lastname: Papoutsi
authors.forename: S
authors.initials: S
authors.lastname: Mitakou
authors.forename: P
authors.initials: P
authors.lastname: Moutsatsou
authors.forename: C
authors.initials: C
authors.lastname: Sekeris
authors.forename: A L
authors.initials: AL
authors.lastname: Skaltsounis
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D007887:Fabaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal; D011485:Protein Binding; D011960:Receptors, Estrogen / Q000378:metabolism*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
chemical_list: C000592622:2-(2,4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-methoxy-5-(3-methylbuten-2-yl)benzofuran; D001572:Benzofurans; D011960:Receptors, Estrogen; D012118:Resorcinols