The control and facilitation of MHC class II antigen processing by the BCR.
Antigens capable of cross-linking the BCR are preferentially captured, processed and presented to MHC-class-II-restricted T cells. Cross-linking antigens initiate tyrosine-kinase-dependent pathways that accelerate the delivery of antigen-receptor complexes to specialized late-endocytic processing compartments. Accelerated trafficking is mediated by the recruitment of signaling molecules required for transience through specific checkpoints along the endocytic pathway.
Siemasko
K
K
Department of Medicine, Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue, MCV0930, Chicago, IL 60637, USA. ksiemask@midway.uchicago.edu
Clark
M R
MR
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000502:physiology*
D000949:Histocompatibility Antigens Class II; D011947:Receptors, Antigen, B-Cell