title: Unilateral fixed dilated pupil in a ventilated child with asthma.
abstract: An 11-year-old boy known to have asthma was referred to our intensive care unit (ICU) with progressive respiratory distress. He was sedated, paralysed, and intubated approximately 3 hours after arrival and nebulization with salbutamol and ipratropium was continued on the ventilator. About 16 hours later, he presented with transient unilateral fixed dilated pupils which resolved spontaneously without any neurological deficit. Computerized tomography scan revealed no signs of generalized cerebral oedema. Local contamination with ipratropium was most likely to be the cause of pupil dilatation, which could have occurred during connecting and disconnecting the nebulization system or through contaminated hands.
authors.affiliation: St. Antonius Hospital, Department of Paediatrics, Nieuwegein, The Netherlands.
authors.forename: S D
authors.initials: SD
authors.lastname: Geraerts
authors.forename: F B
authors.initials: FB
authors.lastname: Plötz
authors.forename: C
authors.initials: C
authors.lastname: van Goor
authors.forename: E L
authors.initials: EL
authors.lastname: Duval
authors.forename: H
authors.initials: H
authors.lastname: van Vught
mesh_terms: D001249:Asthma / Q000628:therapy*; D001993:Bronchodilator Agents / Q000009:adverse effects*; D002648:Child; D006801:Humans; D009241:Ipratropium / Q000009:adverse effects*; D008297:Male; D011681:Pupil Disorders / Q000139:chemically induced*; D012121:Respiration, Artificial
chemical_list: D001993:Bronchodilator Agents; D009241:Ipratropium