Antioxidant activity of parapharmaceutics containing natural inhibitors of free radical processes.
The duration of lag phase of ascorbate-dependent free radical oxidation of endogenous polyenic lipids in rat liver and myocardium considerably increased after oral administration of lacrinat containing licorice Glycyrrhiza glabra root powder for 1 month. Lacrinat markedly decreased the content of lipid peroxides in rat liver. Ex vivo antioxidant effects of lacrinat in rat liver were comparable with those of beta-carotene-containing preparations carinat and carinat CD. Parapharmaceutics containing both licorice Glycyrrhiza glabra root powder and beta-carotene (carinat forte) markedly increased antioxidant activity of the liver.
Konovalova
G G
GG
Laboratory of Biochemistry of Free Radical Processes, AL Myasnikov Institute of Cardiology, Russian Cardiology Research-and-Production Center, Russian Ministry of Health, Moscow.
Tikhaze
A K
AK
Lankin
V Z
VZ
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005609:Free Radicals; D006321:Heart / Q000187:drug effects; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D010936:Plant Extracts; C419905:lacrinat