Diterpene from Baccharis trimera with a relaxant effect on rat vascular smooth muscle.
A bioassay monitored fractionation of a chloroform extract from the aerial parts of Baccharis trimera yielded a mixture that blocked the Ca2+-induced contractions of KCl- depolarized rat portal vein preparations. Pharmacological tests of two pure compounds isolated from the mixture revealed the dilactonic clerodane diterpene as the active compound.
Torres
L M
LM
Universidade Federal de São Paulo, Escola Paulista de Medicina, Department of Pharmacology, SP, Brazil. luce.farm@infar.epm.br
Gamberini
M T
MT
Roque
N F
NF
Lima-Landman
M T
MT
Souccar
C
C
Lapa
A J
AJ
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D004224:Diterpenes