Study of interaction of gastroenterological agents in the presence of cytoprotective drugs. Part I: Adsorption of the chosen inhibitors of histamine H2 receptors on sucralfat in vitro.
We investigated adsorption of the chosen histamine H2 receptor inhibitors on sucralfat. Evaluation of adsorption was conducted by statistic methods in vitro taking into account environment reaction and sucralfat form. The obtained results prove that the tested therapeutic substances are adsorbed on sucralfat in all used pH ranges and the ability of sucralfat bounding depends on its form and environment reaction. The highest adsorption value was observed in the samples with pH 3.6 in the presence of sucralfat suspension, and the lowest in environment pH 1.5 in the presence of sucralfat paste. From among the tested histamine receptors ranitidine hydrochloride is adsorbed in the best way and cimetidine hydrochloride and famotidine in much worse way.
Grimling
B
B
Department of Applied Pharmacy, Wrocław Medical University, 38 Szewska Str., 50-139 Wrocław, Poland.
Pluta
J
J
D000327:Adsorption; D004347:Drug Interactions; D005765:Gastrointestinal Agents / Q000737:chemistry*; D006635:Histamine H2 Antagonists / Q000737:chemistry; D013392:Sucralfate / Q000737:chemistry*; D013816:Thermodynamics
D005765:Gastrointestinal Agents; D006635:Histamine H2 Antagonists; D013392:Sucralfate