title: Spontaneous regression of CIN and delayed-type hypersensitivity to HPV-16 oncoprotein E7.
abstract: We investigated delayed-type hypersensitivity to human papillomavirus (HPV) in women with cervical dysplasia or cancer. Women were challenged by skin tests with synthetic HPV-16 E7 oncoprotein peptides. 11 women were regressors (cleared disease without treatment) and 37 were progressors (required surgery). Antibodies to early antigens (markers for progression) were detectable in a higher proportion of cancer patients than all other patients, particularly progressors with cervical intraepithelial neoplasia (CIN). By contrast, cellular immunity to HPV-16 E7, measured by skin test, was significantly (p=0.0001) associated with clinical and cytological resolution of HPV-induced CIN, indicating that E7-specific T-helper cells have a role in control of HPV.
authors.forename: R
authors.initials: R
authors.lastname: Höpfl
authors.forename: K
authors.initials: K
authors.lastname: Heim
authors.forename: N
authors.initials: N
authors.lastname: Christensen
authors.forename: K
authors.initials: K
authors.lastname: Zumbach
authors.forename: U
authors.initials: U
authors.lastname: Wieland
authors.forename: B
authors.initials: B
authors.lastname: Volgger
authors.forename: A
authors.initials: A
authors.lastname: Widschwendter
authors.forename: S
authors.initials: S
authors.lastname: Haimbuchner
authors.forename: E
authors.initials: E
authors.lastname: Müller-Holzner
authors.forename: M
authors.initials: M
authors.lastname: Pawlita
authors.forename: H
authors.initials: H
authors.lastname: Pfister
authors.forename: P
authors.initials: P
authors.lastname: Fritsch
mesh_terms: D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000821:virology; D008297:Male; D009856:Oncogene Proteins, Viral / Q000276:immunology*; D027383:Papillomaviridae / Q000276:immunology; D050725:Papillomavirus E7 Proteins; D030361:Papillomavirus Infections / Q000276:immunology; D012075:Remission, Spontaneous; D012882:Skin Tests; D014412:Tumor Virus Infections / Q000276:immunology; D002578:Uterine Cervical Dysplasia / Q000276:immunology* / Q000821:virology
chemical_list: D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; C059731:oncogene protein E7, Human papillomavirus type 16