Protein phosphatase 5 in signal transduction.
Protein phosphatase 5 (PP5) possesses unique biochemical properties, which include its tetratricopeptide repeat (TPR) targeting/regulatory domain and its ability to be activated by lipids. PP5 has been studied as a paradigm for TPR protein structure and function. Roles for PP5 in signal transduction are emerging: from cell cycle regulation and signaling by nuclear receptors, to possible regulation of membrane receptors and ion channels.
Chinkers
M
M
Dept of Pharmacology, University of South Alabama, Mobile, AL 36688, USA. michaelc@jaguar1.usouthal.edu
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D006801:Humans; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D009687:Nuclear Proteins; D015221:Potassium Channels; D010749:Phosphoprotein Phosphatases; C089641:protein phosphatase 5