title: Can dietary intake influence plasma levels of amino acids in liver cirrhosis?
abstract: BACKGROUND
  Modifications in plasma amino acid patterns in cirrhotics are attributed to impaired liver function, being more evident in alcoholic than in viral cirrhosis.
  
  
  OBJECTIVE
  To evaluate whether diet influences plasma amino acid concentrations in different aetiological groups of cirrhotics.
  
  
  METHODS
  Study population comprised 40 patients with cirrhosis (25 virus- and 15 alcohol-related], all Child A, and 30 healthy subjects (controls).
  
  
  METHODS
  A food frequency and quality questionnaire was utilized to determine dietary history and alcohol intake. Nutritional status was evaluated by anthropometric method. Amino acids were determined, on venous blood samples, using a specific analyzer while cysteine was evaluated by fluorescent high power liquid chromatography
  
  
  RESULTS
  The total daily intake of calories, proteins, lipids, and carbohydrates was similar in all individuals. Food quality distinguished the cirrhotics from the controls, but not the different aetiological groups of cirrhotics. Plasma cysteine levels were significantly lower, while aromatic amino acids and methionine were significantly higher, in all cirrhotics (p<0.001 and p<0.01, respectively, versus controls). The decrease in cysteine and the increase in other amino acids were more marked in alcoholics (p<0.01).
  
  
  CONCLUSIONS
  Ethanol intake, but not diet, further enhances the changes in plasma aromatic amino acids, methionine and cysteine induced by impaired liver function in patients with cirrhosis, suggesting a direct interference of alcohol in their metabolism.
authors.affiliation: Interuniversity Research Centre on alimentary intake, nutrition and gastrointestinal tract, Gastrointestinal School, Faculty of Medicine, 2nd University of Naples, Italy. caloguer@tin.it
authors.forename: C
authors.initials: C
authors.lastname: Loguercio
authors.forename: F
authors.initials: F
authors.lastname: Del Vecchio Blanco
authors.forename: A
authors.initials: A
authors.lastname: Nastasi
authors.forename: A
authors.initials: A
authors.lastname: Federico
authors.forename: G
authors.initials: G
authors.lastname: Del Vecchio Blanco
authors.forename: V
authors.initials: V
authors.lastname: De Girolamo
authors.forename: D
authors.initials: D
authors.lastname: Disalvo
authors.forename: A
authors.initials: A
authors.lastname: Parente
authors.forename: C
authors.initials: C
authors.lastname: Del Vecchio Blanco
mesh_terms: D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D004032:Diet; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status
chemical_list: D000596:Amino Acids