title: [Selenium correction of male subfertility].
abstract: To study the effect of selenium in subfertile men, three groups of men were studied. Group 1--31 subfertile men living in healthy environment, group 2--25 subfertile men exposed for a long time to low doses of gas containing hydrogen sulfide, group 3--control 43 fertile men. Men of groups 1 and 2 received 3 courses of selenium (3.5 microg/kg/day for 30 days). Before the treatment and after each course ejaculate fertility was assessed by spermogram, enzyme activity of alpha-amylase (EC 3.2.1.1) and lactate dehydrogenase (EC 1.1.1.27), concentrations of prostatic acid phosphatase, sperm-specific inhibitor tripsin and prostate-specific antigen. Selenium proved effective, the response being higher in group 2 than in group 1. The causes of this difference are discussed. It is thought possible to use selenium for correction of some subfertility forms in men.
authors.forename: A A
authors.initials: AA
authors.lastname: Nikolaev
authors.forename: D L
authors.initials: DL
authors.lastname: Lutskiĭ
authors.forename: L V
authors.initials: LV
authors.lastname: Lozhkina
authors.forename: V A
authors.initials: VA
authors.lastname: Bochanovskiĭ
authors.forename: L A
authors.initials: LA
authors.lastname: Goncharova
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D006862:Hydrogen Sulfide / Q000009:adverse effects; D007248:Infertility, Male / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D010940:Plant Proteins / Q000378:metabolism; D011379:Prognosis; D011467:Prostate / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000378:metabolism; D012643:Selenium / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D014361:Trypsin Inhibitors; D000516:alpha-Amylases / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D010940:Plant Proteins; D014361:Trypsin Inhibitors; D007770:L-Lactate Dehydrogenase; D000135:Acid Phosphatase; D000516:alpha-Amylases; D017430:Prostate-Specific Antigen; D012643:Selenium; D006862:Hydrogen Sulfide