Pyrrolidine PNA: a novel conformationally restricted PNA analogue.
[reaction:see text] A new conformationally restricted PNA adenine monomer has been synthesized in 13 steps from cis-4-hydroxy-D-proline. A fully modified adenine decamer displayed improved binding affinity toward complementary DNA and RNA oligonucleotides as compared to that of the parent PNA adenine decamer.
Püschl
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Center for Biomolecular Recognition, Department for Biochemistry and Genetics, Biochemistry Laboratory B, The Panum Institute, Blegdamsvej 3C, DK-2200, Copenhagen, Denmark. ask@kiku.dk
Tedeschi
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Nielsen
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PE
D004247:DNA / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
D020135:Peptide Nucleic Acids; D011759:Pyrrolidines; D004247:DNA