title: Idiopathic hypocomplementemic interstitial nephritis with extensive tubulointerstitial deposits.
abstract: Most forms of interstitial nephritis are cell mediated and lack tubulointerstitial immune deposits. These forms include allergic, infectious, and idiopathic interstitial nephritis. Immune complex deposits in the tubular basement membranes and interstitium most commonly are encountered in conjunction with glomerular diseases. Predominantly tubulointerstitial immune deposits without significant glomerular involvement can occur in Sjögren's syndrome and in a small subset of lupus nephritis. We report eight unusual cases of tubulointerstitial nephritis with massive tubulointerstitial immune deposits occurring in adults with hypocomplementemia and no evidence of systemic lupus erythematosus or Sjögren's disease. Most patients were older men. The renal biopsy specimens manifested a spectrum of changes ranging from tubulointerstitial nephritis to atypical lymphoid hyperplasia to changes suggestive of marginal zone B-cell lymphoma. Chronic local antigenic stimulation may predispose to lymphoma in these cases, analogous to what is postulated to occur in cases of mucosa-associated lymphoid tissue (MALT) lymphomas in extranodal sites, such as salivary gland, stomach, and thyroid. The preferential tubulointerstitial immune deposition and significant interstitial plasma cell component suggest pathomechanisms that involve local immune complex formation.
authors.affiliation: Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, NY, USA. vdd1@columbia.edu
authors.forename: N
authors.initials: N
authors.lastname: Kambham
authors.forename: G S
authors.initials: GS
authors.lastname: Markowitz
authors.forename: N
authors.initials: N
authors.lastname: Tanji
authors.forename: M M
authors.initials: MM
authors.lastname: Mansukhani
authors.forename: A
authors.initials: A
authors.lastname: Orazi
authors.forename: V D
authors.initials: VD
authors.lastname: D'Agati
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005455:Fluorescent Antibody Technique; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007165:Immunosuppression Therapy; D007668:Kidney / Q000473:pathology; D007684:Kidney Tubules / Q000276:immunology* / Q000473:pathology* / Q000648:ultrastructure; D008214:Lymphocytes; D016393:Lymphoma, B-Cell / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000188:drug therapy / Q000473:pathology*