Periarterial electrical nerve stimulation-induced adrenergic vasoconstriction inhibited by adrenergic alpha1B-receptor blockade but not by alpha1A-blockade.
The periarterial electrical nerve stimulation at a frequency of 4 Hz (30-s trains of pulses) induced a double-peaked vasoconstriction in the canine splenic artery. The treatment with chloroethylclonidine (CEC, 60 microM) markedly inhibited the second-peaked constriction, whereas it produced an insignificant effect on the first-peaked response. The vasoconstriction to noradrenaline (NA, 1 nmol) was not significantly influenced by 60 microM CEC. On the other hand, WB 4101 (1 microM) consistently abolished the vascular response induced by NA (1 nmol), but rather potentiated the double-peaked constriction. The results indicate that neuronal NA may junctionally exert its vasoconstrictor effect via an activation of postjunctional alpha1B-receptors, whereas exogenous NA may extrajunctionally activate alpha1A-receptors for its vascular action in the canine splenic artery.
Yang
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XP
Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan.
Chiba
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D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology; D010525:Peripheral Nerves / Q000502:physiology*; D018340:Receptors, Adrenergic, alpha-1 / Q000187:drug effects* / Q000502:physiology; D013157:Splenic Artery / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D018340:Receptors, Adrenergic, alpha-1; D014662:Vasoconstrictor Agents; D009638:Norepinephrine