Etiology and pathophysiology of chronic transplant dysfunction.
Chronic transplant dysfunction (CTD) is the predominant cause of late graft failure. The common histopathological feature in all transplanted organs is intimal hyperplasia accompanied by organ specific lesions. The knowledge about CTD is incomplete, and there is no therapy to prevent or treat it. This review describes the current knowledge on the etiology of CTD, with emphasis on kidney transplants, and postulates a pathophysiologic route through which CTD may develop.
Kouwenhoven
E A
EA
Department of Surgery, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
IJzermans
J N
JN
de Bruin
R W
RW
D000208:Acute Disease; D000818:Animals; D002102:Cadaver; D002908:Chronic Disease; D015331:Cohort Studies; D016207:Cytokines / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D006084:Graft Rejection / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control; D006085:Graft Survival; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D006965:Hyperplasia; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007511:Ischemia / Q000209:etiology / Q000473:pathology; D007518:Isoantibodies / Q000276:immunology; D008262:Macrophage Activation; D051379:Mice; D015337:Multicenter Studies as Topic; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D011183:Postoperative Complications; D051381:Rats; D012307:Risk Factors; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014019:Tissue Donors; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D017539:Tunica Intima / Q000473:pathology
D016207:Cytokines; D006133:Growth Substances; D007166:Immunosuppressive Agents; D007518:Isoantibodies