Cell motility: proline-rich proteins promote protrusions.
Many proline-rich proteins participate in delivering actin monomers to specific cellular locations where actin-rich membrane protrusions, such as ruffles, filopodia and microspikes, are formed. These protrusions are necessary for cell motility. Actin monomer is usually delivered to the site of polymerization in the form of profilactin - a complex of G-actin with a polyproline-binding protein, profilin. Here, we describe proline-rich proteins involved in regulating actin polymerization and classify them according to their role in recruiting profilin to the membrane.
Holt
M R
MR
Department of Physiology, University College London, 21 University Street, WC1E 6JJ., London, UK.
Koffer
A
A
D000199:Actins / Q000502:physiology*; D020816:Amino Acid Motifs; D002465:Cell Movement / Q000502:physiology*; D003285:Contractile Proteins; D008840:Microfilament Proteins / Q000502:physiology; D010455:Peptides / Q000502:physiology*; D051304:Profilins; D011392:Proline; D055232:Proline-Rich Protein Domains; D011506:Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D000199:Actins; D003285:Contractile Proteins; D008840:Microfilament Proteins; D010455:Peptides; D051304:Profilins; D011506:Proteins; C024782:profilactin; D011392:Proline; D020741:rho GTP-Binding Proteins