title: Quantitative expression analysis of the small conductance calcium-activated potassium channels, SK1, SK2 and SK3, in human brain.
abstract: Small conductance calcium-activated potassium (SK) channels are important in controlling neuronal excitability and three SK channels have been identified to date. In the present study, we report the first quantitative analysis of SK1, SK2 and SK3 expression in human brain using TaqMan RT-PCR on a range of human brain and peripheral tissue samples. SK1 expression is restricted to the brain whereas SK2 and SK3 are more widely expressed.
authors.affiliation: Molecular Biology and Biochemistry Unit, Biology Department, GlaxoWellcome Medicines Research Centre, Via A. Fleming 4, 37135 Verona, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Rimini
authors.forename: J M
authors.initials: JM
authors.lastname: Rimland
authors.forename: G C
authors.initials: GC
authors.lastname: Terstappen
mesh_terms: D001923:Brain Chemistry / Q000235:genetics*; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D015221:Potassium Channels / Q000235:genetics*; D024681:Potassium Channels, Calcium-Activated; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051640:Small-Conductance Calcium-Activated Potassium Channels; D014158:Transcription, Genetic / Q000502:physiology
chemical_list: C496894:KCNN1 protein, human; C496897:KCNN2 protein, human; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels