Correlation between cholesterol, soluble P-selectin, and D-dimer in obese children and adolescents.
Thirty-eight obese children and adolescents were investigated for a possible relation between cholesterol and markers of platelet activation, endothelial cell dysfunction, and activation of the coagulation system. Soluble P-selectin, von Willebrand factor antigen (vWf-Ag), D-dimer, and prothrombin fragment 1 + 2 (F1 + 2) were determined by enzyme-linked immunosorbent assays, and factor VIII coagulant activity (VIIIc) was measured by means of one-stage clotting assay. Cholesterol correlated significantly with log P-selectin (r = 0.43, P = 0.003) and log D-dimer (r = 0.33, P = 0.02). Cholesterol did not correlate with vWf-Ag, factor VIIIc, and F1 + 2. Log P-selectin correlated significantly with log D-dimer (r = 0.42, P = 0.003), which remained significant after adjustment for cholesterol (P = 0.02). Log D-dimer correlated significantly with F1 + 2 (r = 0.38, P = 0.01). Our study demonstrates that, in obese children and adolescents, cholesterol is significantly associated with P-selectin and D-dimer, and suggests an unfavorable intercorrelation between metabolic and hemostatic risk factors for coronary heart disease in childhood obesity.
Gallistl
S
S
Ludwig Boltzmann Research Institute for Pediatric Hemostasis and Thrombosis, Department of Pediatrics, University of Graz, Austria. Siegfried.gallistl@kfunigraz.ac.at
Sudi
K M
KM
Borkenstein
M
M
Weinhandl
G
G
Zotter
H
H
Muntean
W
W
D000293:Adolescent; D001777:Blood Coagulation; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood*; D019007:P-Selectin / Q000097:blood*
D005338:Fibrin Fibrinogen Degradation Products; D019007:P-Selectin; C036309:fibrin fragment D; D002784:Cholesterol