The effect of a new tissue-adhesive wound dressing on the healing of traumatic abrasions.
BACKGROUND
Octylcyanoacrylate is a new medical-grade adhesive with antimicrobial properties. It forms a thin, flexible, occlusive bandage.


OBJECTIVE
To determine the gross and histological effects of the spray bandage when treating abrasions.


METHODS
Abrasions were produced on the flanks of 18 albino guinea pigs and randomized to treatment with a control (Biobrane) or octylcyanoacrylate dressing. The wounds were assessed with digital photography using a previously validated method. Histopathological analysis was done on day 14.


RESULTS
There were no differences in the mean wound-healing ratios on days 1 (1.25 vs. 1.23, p = 0.61), 7 (1.15 vs. 1.13, p = 0. 14) and 14 (1.03 vs. 1.02, p = 0.63) for tissue adhesive and Biobrane, respectively. There were no differences found on histopathological analysis either.


CONCLUSIONS
This external spray bandage was well tolerated and did not show any signs of histotoxicity or adverse wound healing.
Quinn
J
J
Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA. quinnj@medicine.ucsf.edu
Lowe
L
L
Mertz
M
M
D000818:Animals; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use; D003487:Cyanoacrylates / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D009779:Occlusive Dressings; D012867:Skin / Q000187:drug effects / Q000293:injuries; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014945:Wound Healing; D014950:Wounds, Penetrating / Q000628:therapy*
C042816:Biobrane; D020099:Coated Materials, Biocompatible; D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate