title: Management of hydrocephalus.
abstract: The present study is an analysis of 747 patients with hydrocephalus, treated and followed up in the Hydrocephalus Clinic run by the department of Paediatric Surgery at the All India Institute of Medical Sciences, New Delhi. The distribution of patients was: congenital-46%, post-meningomyelocoele excision-28%, post-meningitic-21% and others-5% (including post haemorrhagic and post encephalocoele excision hydrocephalus. The average age was 7 months in the shunted group and 10 months in the medical group with overall male to female ratio of 2.3:1. The data were analysed to study the effect of treatment on ventriculomegaly and mental development with special reference to the type of treatment (shunt versus medical) and age at starting treatment. The probability of shunt failure was also studied. A comparison of ventricular size in US/CAT scans between the time of starting treatment and last follow-up revealed improvement in ventriculomegaly in 60% of the shunted patients but only 30% of the medically treated patients. A significant difference was particularly noted in patients with severe hydrocephalus, 72% and 22%, respectively. Comparison of the mean Mental Performance Quotient (MPQ) scores in the shunted & medically treated patients also revealed significantly better MPQ scores in the shunted group (p = < 0.001). Probability of shunt survival, as depicted by the Kaplan-Meier survival curve, revealed that there is a high rate of shunt failure in the first 12 months, followed by a dramatic slowing down. Our observations support the contention that CSF shunt surgery offers better outcome than medical management even when ventriculomegaly is severe at the time of presentation.
authors.affiliation: Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi.
authors.forename: M
authors.initials: M
authors.lastname: Bajpai
authors.forename: R
authors.initials: R
authors.lastname: Kataria
authors.forename: V
authors.initials: V
authors.lastname: Bhatnagar
authors.forename: S
authors.initials: S
authors.lastname: Agarwala
authors.forename: D K
authors.initials: DK
authors.lastname: Gupta
authors.forename: M
authors.initials: M
authors.lastname: Bharadwaj
authors.forename: K
authors.initials: K
authors.lastname: Das
authors.forename: A
authors.initials: A
authors.lastname: Alladi
authors.forename: T
authors.initials: T
authors.lastname: Lama
authors.forename: M
authors.initials: M
authors.lastname: Srinivas
authors.forename: S
authors.initials: S
authors.lastname: Dave
authors.forename: M
authors.initials: M
authors.lastname: Arora
authors.forename: H
authors.initials: H
authors.lastname: Dutta
authors.forename: R M
authors.initials: RM
authors.lastname: Pandey
authors.forename: D K
authors.initials: DK
authors.lastname: Mitra
mesh_terms: D002552:Cerebral Ventricles / Q000473:pathology; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006984:Hypertrophy; D007223:Infant; D008607:Intellectual Disability / Q000175:diagnosis / Q000209:etiology; D007361:Intelligence Tests; D008297:Male; D018579:Patient Selection; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome