Peptidergic input to immunohistochemically-identified Renshaw cells.
Peptidergic influences on Renshaw cells were assessed in rat using gephyrin-immunoreactivity, as a Renshaw cell specific marker, in combination with substance P, calcitonin gene-related peptide- and nicotinic acetylcholine receptor-immunolabelling. An average of 3.9 substance P-, and 8.1 calcitonin gene-related peptide-, and 16.3 nicotinic acetylcholine receptor-immunoreactive close contacts or puncta were observed per Renshaw cell. Most appositions were somatic. These results provide neuroanatomical support for the peptidergic modulation of Renshaw cells.
Carr
P A
PA
Department of Anatomy and Cell Biology, University of North Dakota, Grand Forks 58202, USA. pcarr@medicine.nodak.edu
Roller
M J
MJ
Zaruba
R A
RA
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D007150:Immunohistochemistry; D008161:Lumbosacral Region; D008297:Male; D009474:Neurons / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011978:Receptors, Nicotinic / Q000032:analysis*; D013116:Spinal Cord / Q000737:chemistry*; D013373:Substance P / Q000032:analysis*
D011978:Receptors, Nicotinic; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide