title: Native bovine bone morphogenetic protein improves the potential of biocoral to heal segmental canine ulnar defects.
abstract: We studied the effect of a composite implant consisting of coral and native bovine bone morphogenetic protein (BMP) on the healing of 2 cm segmental defects in the canine ulna. Plain coral and cortical autograft bone implants were used as controls. The fixation was temporary for 9 weeks with an intramedullary Kirschner wire (6 ulnas with a composite implant of coral and BMP, 6 with plain coral and 6 with an autograft) or a plate and screws (3 ulnas with a composite implant and 3 with plain coral). X-rays were taken at 3, 6, 9, 12, 16, 26 and 36 weeks, and mechanical torsion tests were performed at the end of the study. The score for bone formation and bone union evaluated from radiographs was significantly higher in the composite implant group than in the plain coral group at 16 weeks, but the score was even higher with autografts. BMP accelerated the resorption of the coral implant. The mechanical strength of the composite implants was higher than that of the bones with a plain coral implant (P < 0.05), while the mechanical strength of the coral implants, even with BMP, was significantly lower than the strength of autografts (P < 0.01). In conclusion, BMP enhanced the capacity of a coral implant to heal a segmental ulnar defect by increasing bone formation, but the effect of this combination was not as good as that of a cortico-cancellous autograft.
authors.affiliation: Department of Surgery, Bone Transplantation Research Group, P.O. Box 5000, 90014 University of Oulu, Oulu, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Tuominen
authors.forename: T
authors.initials: T
authors.lastname: Jämsä
authors.forename: J
authors.initials: J
authors.lastname: Tuukkanen
authors.forename: P
authors.initials: P
authors.lastname: Nieminen
authors.forename: T C
authors.initials: TC
authors.lastname: Lindholm
authors.forename: T S
authors.initials: TS
authors.lastname: Lindholm
authors.forename: P
authors.initials: P
authors.lastname: Jalovaara
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D018786:Bone Substitutes; D016025:Bone Transplantation; D003063:Cnidaria; D004285:Dogs; D005260:Female; D008297:Male; D019736:Prostheses and Implants; D014182:Transplantation, Autologous; D014457:Ulna / Q000293:injuries*; D014945:Wound Healing / Q000502:physiology
chemical_list: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes