title: Hedgehog signaling in vertebrate and invertebrate limb patterning.
abstract: Invertebrate and vertebrate limbs have very different anatomies and modes of development. Despite these differences, recent studies demonstrate that a significant overlap exists in the signals used to pattern invertebrate and vertebrate limbs. One of these signaling molecules is Hedgehog, a secreted protein that functions to coordinate growth and proliferation along the anterior-posterior axis of developing limbs. Recent studies indicate that the mechanism of action, regulation and function of Hedgehog signaling in Drosophila and vertebrate limb development are often quite similar, yet at other times are distinct. Here we highlight the similarities and differences between the use of Hedgehog signaling in these two systems.
authors.affiliation: Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla California 92037-1099, USA. jcapdevila@ems.salk.edu
authors.forename: J
authors.initials: J
authors.lastname: Capdevila
authors.forename: R L
authors.initials: RL
authors.lastname: Johnson
mesh_terms: D000818:Animals; D019521:Body Patterning; D004330:Drosophila / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins; D005121:Extremities / Q000254:growth & development*; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology*; D007448:Invertebrates / Q000235:genetics / Q000254:growth & development; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D015534:Trans-Activators; D014714:Vertebrates / Q000235:genetics / Q000254:growth & development; D014921:Wings, Animal / Q000254:growth & development
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D011506:Proteins; D015534:Trans-Activators; C077245:hh protein, Drosophila