title: Competence modulation by the NADH oxidase of Streptococcus pneumoniae involves signal transduction.
abstract: Oxygen controls competence development in Streptococcus pneumoniae. Oxygen signaling involves the two-component signal transduction systems CiaRH and ComDE and the competence-stimulating peptide encoded by comC and processed by ComAB. We found that NADH oxidase (Nox) was required for optimal competence. Transcriptional analysis and genetic dissection showed that Nox was involved in post-transcriptional activation of the response regulator ComE and in the transcriptional control of ciaRH and comCDE. Thus, in S. pneumoniae, Nox, with O(2) as its secondary substrate, is part of the O(2)-signaling pathway.
authors.affiliation: Laboratoire de Genétique et Physiologie Bactérienne, Centre Hospitalo Universitaire de Rangueil, Université Paul Sabatier, 31403 Toulouse Cedex, France.
authors.forename: J R
authors.initials: JR
authors.lastname: Echenique
authors.forename: M C
authors.initials: MC
authors.lastname: Trombe
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000378:metabolism*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction; D013296:Streptococcus pneumoniae / Q000235:genetics*; D014169:Transformation, Bacterial
chemical_list: D001426:Bacterial Proteins; C103179:ComE protein, Streptococcus pneumoniae; D009097:Multienzyme Complexes; C061650:comC protein, Bacillus subtilis; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; D011494:Protein Kinases