title: [Acute normovolemic hemodilutin (ANH). Effects of ANH on the diastolic function of the left ventricle].
abstract: Ischemia-induced changes of diastolic leftventricular (LV) properties commonly precede corresponding ECG-changes. In the present experimental study the consequences of acute normovolemic hemodilution (ANH) induced dilutional anemia (hematocrit, hct 20%) for LV diastolic function were investigated. A total of 22 anaesthetized, splenectomized beagle dogs breathing room air were hemodiluted with isooncotic hydroxyethylstarch solution (6% HAES 200,000/0.5) until a hct value of 20% was reached. Before and after ANH intravascular blood volume (indocyaningreen dilution technique), global and regional myocardial blood flow (radioactive microspheres technique) and the following parameters reflecting LV diastolic properties were ascertained: 1) the maximum rate of LV pressure decrease (LVdp/dtmin), 2) slope and intercept of the enddiastolic pressure-volume relationship (EDPVR, conductance technique) and 3) the time-constant of isovolumic LV pressure decline "tau". After ANH to hct 20% diastolic LV function was found unchanged. Particularly the load-independent parameters (EDPVR-slope and tau) remained constant. The decrease of LV dp/dtmin (-2724 +/- 479 vs. -2388 +/- 408 mmHg.sek-1; p < 0.05) reflects ANH induced changes of LV pre- and afterload. Signs of subendocardial perfusion mismatch were not encountered. Presumed that the coronary vascular system is intact ANH to hct 20% does not provoque changes of LV diastolic function. Moreover neither myocardial perfusion and oxygenation nor myocardial function are endangered by this degree of dilutional anemia.
authors.affiliation: Klinik für Anästhesiologie, Ludwig-Maximilians-Universität, München. habler@icf.med.uni-muenchen.de
authors.forename: O
authors.initials: O
authors.lastname: Habler
authors.forename: M
authors.initials: M
authors.lastname: Kleen
authors.forename: A
authors.initials: A
authors.lastname: Podtschaske
authors.forename: J
authors.initials: J
authors.lastname: Hutter
authors.forename: M
authors.initials: M
authors.lastname: Tiede
authors.forename: G
authors.initials: G
authors.lastname: Kemming
authors.forename: K
authors.initials: K
authors.lastname: Messmer
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000502:physiology; D004396:Coloring Agents; D003326:Coronary Circulation; D003971:Diastole / Q000502:physiology; D004285:Dogs; D004562:Electrocardiography; D006438:Hemodilution; D007208:Indocyanine Green; D010100:Oxygen / Q000097:blood; D013156:Splenectomy; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green; D010100:Oxygen