title: Design and synthesis of new DNA photocleavers, 4'-bromoace-tophenone-pyrrolecarboxamide hybrid compounds.
abstract: 4-Bromoacetophenone-pyrrolecarboxamide conjugates were designed and synthesized as photoinducible DNA cleaving agents which can generate monophenyl radicals capable of causing the hydrogen atom abstraction which initiates the scission of DNA.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, Seoul, Korea. rjeon@sookmyung.ac.kr
authors.forename: R
authors.initials: R
authors.lastname: Jeon
authors.forename: P A
authors.initials: PA
authors.lastname: Wender
mesh_terms: D004247:DNA / Q000187:drug effects*; D015195:Drug Design; D007202:Indicators and Reagents; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D012997:Solvents
chemical_list: D007202:Indicators and Reagents; D011758:Pyrroles; D012997:Solvents; D004247:DNA