title: Concurrent validity of negative symptom assessments in treatment refractory schizophrenia: relationship between interview-based ratings and inpatient ward observations.
abstract: The concurrent validity of interview-based ratings of negative symptoms in 35 inpatients with chronic, treatment refractory schizophrenia was evaluated. Correlations were examined between interview-based ratings of negative symptoms, measured by the Brief Psychiatric Rating Scale and the Positive and Negative Syndrome Scale, and the naturalistic behavior of inpatients as assessed by the Time Sample Behavior Checklist. Higher levels of interview-based negative symptoms were related to reduced interpersonal activity on the inpatient ward, but not to entertainment, instrumental or self-maintenance activities. These findings offer partial support for the concurrent validity of office-based ratings of negative symptoms, and highlight the importance of longitudinal observations of patients for accurate identification of negative symptoms.
authors.affiliation: Division of Psychology, Harbor-UCLA Medical Center, 1000 West Carson Street, Box 488, Torrance, CA 90509, USA. egilbert@ucla.edu
authors.forename: E A
authors.initials: EA
authors.lastname: Gilbert
authors.forename: R P
authors.initials: RP
authors.lastname: Liberman
authors.forename: J
authors.initials: J
authors.lastname: Ventura
authors.forename: R
authors.initials: R
authors.lastname: Kern
authors.forename: M J
authors.initials: MJ
authors.lastname: Robertson
authors.forename: S
authors.initials: S
authors.lastname: Hwang
authors.forename: M F
authors.initials: MF
authors.lastname: Green
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D010054:Brief Psychiatric Rating Scale; D004311:Double-Blind Method; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use*; D006760:Hospitalization; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D008875:Middle Aged; D019370:Observation; D011446:Prospective Studies; D015203:Reproducibility of Results; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000534:rehabilitation; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D006220:Haloperidol; D018967:Risperidone