Defects in B-cell function and metabolism in uremia: role of parathyroid hormone.
Patients with chronic renal failure have impaired humoral immunity, inadequate B-cell proliferation and antibody production, and elevated basal levels of cytosolic calcium ([Ca2+]i) in their B cells. Multiple mechanisms can be involved in generation of these derangements. This article reviews data suggesting that high levels of parathyroid hormone (PTH) of uremia affect the metabolism and function of B cells. We also review studies on the role of normalization of [Ca2+]i in these abnormalities. Small but well-documented studies suggest that treatment of dialysis patients with calcium channels blockers can reverse the elevation of [Ca2+]i in B cells, which was followed by improvement of B-cell function. Thus, therapy with calcium channel blockers has the potential to decrease the infectious complication of uremia.
Smogorzewski
M
M
Division of Nephrology, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
Massry
S G
SG
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002455:Cell Division; D000242:Cyclic AMP / Q000096:biosynthesis; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D009543:Nifedipine / Q000494:pharmacology; D010281:Parathyroid Hormone / Q000378:metabolism* / Q000494:pharmacology; D014511:Uremia / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*
D002121:Calcium Channel Blockers; D010281:Parathyroid Hormone; D000242:Cyclic AMP; D009543:Nifedipine; D002118:Calcium