Value of p53 protein in biological behavior of basal cell carcinoma and in normal epithelia adjacent to carcinomas.
Mutations in p53 gene are the most frequent gene alterations in human cancer. In this study, we have used the monoclonal antibody (DO7) to evaluate the role of the p53 gene mutation in the progression of basal cell carcinomas towards invasion. We tested the positivity for p53 protein in tumor cells in six cases of basosquamous cell carcinoma (BSCC), in twelve cases of infiltrative basal cell carcinoma (IBCC) and twenty-four cases of non-infiltrative basal cell carcinoma (NIBCC) in order to evaluate its potential prognostic significance. We also tested the expression of p53 protein in normal epithelia adjacent to carcinomas in order to determine its role in tumor progression. p53 protein staining with some peripheral accentuation was identified in 42,9% of all groups. No correlation was found between the immunreactivity of p53 protein and recurrence, pattern of tumor, diameter of the tumors and sex. However, there were statistically significant differences in positivity of p53 protein in normal epithelia adjacent to carcinomas and age of patients (t value: 2,21; p: 0,034). Results of the study suggest that the increasein p53 mutation frequency of morphologically normal epidermis was related to age and was independent of the degree of differentiation of BCC.
Demirkan
N C
NC
Department of Pathology, Pamukkale University, 269 sok. No: 46-8 Ucyol, Izmir, 35280, Turkey. nesefahir@hotmail.com
Colakoglu
N
N
Düzcan
E
E
D000367:Age Factors; D000368:Aged; D002280:Basal Cell Carcinoma / Q000473:pathology*; D018450:Disease Progression; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53