Cutaneous immunocytoma presenting with multiple infiltrated macules and papules.
Cutaneous immunocytomas are low-grade malignant B-cell lymphomas that arise in the skin as solitary or multiple papules, plaques, or nodules. We describe a female patient with lymphoplasmocytic lymphoma who presented with multiple, brown-red to bluish macules and papules on the left thigh. The proliferation was monoclonal as evaluated by positive staining of the plasma cells with antibodies against IgG heavy chain and lambda-light chain and with polymerase chain reaction showing immunoglobulin heavy-chain gene rearrangement. Neither paraproteinemia nor involvement of bone marrow was present.
Aberer
E
E
Department of Dermatology, University of Graz, Austria. elisabeth.aberer@kfunigraz.ac.at
Cerroni
L
L
Kerl
H
H
D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D016898:Interferon-alpha / Q000627:therapeutic use; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D017444:Skin Diseases, Papulosquamous / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*
D016898:Interferon-alpha