Gene diversity of chimpanzee ABO blood group genes elucidated from exon 7 sequences.
Human and non-human primate ABO blood group genes show relatively large numbers of nucleotide differences. In this study, we determined exon 7 sequences for 10 individuals of common chimpanzee and for four individuals of bonobo to estimate nucleotide diversities among them. Sequence data showed the existence of chimpanzee specific 9-base deletion in the beginning of the exon 7 coding region. From a phylogenetic network of exon 7 sequences of ABO blood group genes for human, common chimpanzee, bonobo and gorilla, effects of parallel substitutions and/or some kinds of convergent events are inferred in the chimpanzee lineage. We also estimated nucleotide diversities for common chimpanzee and bonobo ABO blood group genes, and these values were 0.4% and 0.2%, respectively. These values are higher than that of most human genes.
Sumiyama
K
K
Laboratory of Evolutionary Genetics, National Institute of Genetics, Mishima 411-8540, Japan.
Kitano
T
T
Noda
R
R
Ferrell
R E
RE
Saitou
N
N
D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005091:Exons / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D016695:Glycosyltransferases / Q000235:genetics*; D006071:Gorilla gorilla / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D019974:Pan paniscus / Q000235:genetics; D002679:Pan troglodytes / Q000235:genetics*; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
D000017:ABO Blood-Group System; D004247:DNA; D016695:Glycosyltransferases