Evaluation of anti-pyretic potential of Jussiaea suffruticosa L. extract in rats.
A study was carried out to evaluate the anti-pyretic potential of the methanol extract of the aerial part of Jussiaea suffruticosa Linn. (MEJS) on normal body temperature and yeast-induced pyrexia in albino rats. Yeast suspension (10 ml/kg body wt.) increased rectal temperature after 19 hours of subcutaneous injection. The MEJS, at doses of 100, 200 and 300 mg/kg body wt. p.o., showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect also extended up to 5 hours after the drug administration. The anti-pyretic effect of MEJS was comparable to that of paracetamol (150 mg/kg body wt, p.o.), a standard anti-pyretic agent.
Murugesan
T
T
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Mandal
S C
SC
Bhakta
T
T
Das
J
J
Pal
M
M
Saha
B P
BP
D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D015003:Yeasts
D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts