title: Effects of perfluorochemical distribution and elimination dynamics on cardiopulmonary function.
abstract: Based on a physicochemical property profile, we tested the hypothesis that different perfluorochemical (PFC) liquids may have distinct effects on intrapulmonary PFC distribution, lung function, and PFC elimination kinetics during partial liquid ventilation (PLV). Young rabbits were studied in five groups [healthy, PLV with perflubron (PFB) or with perfluorodecalin (DEC); saline lavage injury and conventional mechanical ventilation (CMV); saline lavage injury PLV with PFB or with DEC]. Arterial blood chemistry, respiratory compliance (Cr), quantitative computed tomography of PFC distribution, and PFC loss rate were assessed for 4 h. Initial distribution of PFB was more homogenous than that of DEC; over time, PFB redistributed to dependent regions whereas DEC distribution was relatively constant. PFC loss rate decreased over time in all groups, was higher with DEC than PFB, and was lower with injury. In healthy animals, arterial PO(2) (Pa(O(2))) and Cr decreased with either PFC; the decrease was greater and sustained with DEC. Lavaged animals treated with either PFC demonstrated increased Pa(O(2)), which was sustained with PFB but deteriorated with DEC. Lavaged animals treated with PFB demonstrated increased Cr, higher Pa(O(2)), and lower arterial PCO(2) than with CMV or PLV with DEC. The results indicate that 1) initial distribution and subsequent intrapulmonary redistribution of PFC are related to PFC properties; 2) PFC distribution influences PFC elimination, gas exchange, and Cr; and 3) PFC elimination, gas exchange, and Cr are influenced by PFC properties and lung condition.
authors.affiliation: Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
authors.forename: T F
authors.initials: TF
authors.lastname: Miller
authors.forename: B
authors.initials: B
authors.lastname: Milestone
authors.forename: R
authors.initials: R
authors.lastname: Stern
authors.forename: T H
authors.initials: TH
authors.lastname: Shaffer
authors.forename: M R
authors.initials: MR
authors.lastname: Wolfson
mesh_terms: D000818:Animals; D005466:Fluorocarbons / Q000493:pharmacokinetics* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006842:Hydrocarbons, Brominated; D007700:Kinetics; D021061:Liquid Ventilation; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D008170:Lung Compliance; D008657:Metabolic Clearance Rate; D010100:Oxygen / Q000097:blood; D011817:Rabbits; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
chemical_list: D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C008805:perfluorodecalin; C003072:perflubron; D010100:Oxygen