title: Cure of undifferentiated small cell carcinoma of the urinary bladder with M-VAC chemotherapy.
abstract: Small cell carcinoma (SCC) of the urinary bladder is a rare, aggressive malignancy with approximately 135 cases reported in the literature. Treatments have included chemotherapy, radical surgery, radiotherapy, and combinations of these. We present the apparent cure of a 73-year-old man who presented with clinical stage T2 SCC of the urinary bladder. He was treated with three cycles of methotrexate, vinblastine, Adriamycin (doxorubicin), and cisplatin (M-VAC) chemotherapy. Subsequent radical cystoprostatectomy revealed no pathologic evidence of tumor. The patient is alive and well with no evidence of recurrence 3 years post cystectomy. A brief review of the literature is also presented.
authors.affiliation: Squier Urological Clinic, College of Physicians and Surgeons, Columbia University, 10032, New York, NY, USA
authors.forename: R J.
authors.initials: RJ
authors.lastname: Nejat
authors.forename: R
authors.initials: R
authors.lastname: Purohit
authors.forename: E T.
authors.initials: ET
authors.lastname: Goluboff
authors.forename: D
authors.initials: D
authors.lastname: Petrylak
authors.forename: M A.
authors.initials: MA
authors.lastname: Rubin
authors.forename: M C.
authors.initials: MC
authors.lastname: Benson