title: The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.
abstract: The Notch signalling pathway has recently been implicated in the development and patterning of the sensory epithelium in the cochlea, the organ of Corti. As part of an ongoing large-scale mutagenesis programme to identify new deaf or vestibular mouse mutants, we have identified a novel mouse mutant, slalom, which shows abnormalities in the patterning of hair cells in the organ of Corti and missing ampullae, structures that house the sensory epithelia of the semicircular canals. We show that the slalom mutant carries a mutation in the Jagged1 gene, implicating a new ligand in the signalling processes that pattern the inner ear neuro-epithelium.
authors.affiliation: MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK.
authors.forename: H
authors.initials: H
authors.lastname: Tsai
authors.forename: R E
authors.initials: RE
authors.lastname: Hardisty
authors.forename: C
authors.initials: C
authors.lastname: Rhodes
authors.forename: A E
authors.initials: AE
authors.lastname: Kiernan
authors.forename: P
authors.initials: P
authors.lastname: Roby
authors.forename: Z
authors.initials: Z
authors.lastname: Tymowska-Lalanne
authors.forename: P
authors.initials: P
authors.lastname: Mburu
authors.forename: S
authors.initials: S
authors.lastname: Rastan
authors.forename: A J
authors.initials: AJ
authors.lastname: Hunter
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
authors.forename: K P
authors.initials: KP
authors.lastname: Steel
mesh_terms: D000818:Animals; D001483:Base Sequence; D019521:Body Patterning; D002135:Calcium-Binding Proteins; D003001:Cloning, Molecular; D017931:DNA Primers; D006720:Homozygote; D036341:Intercellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008809:Mice, Inbred C3H; D008855:Microscopy, Electron, Scanning; D009154:Mutation; D009436:Neural Tube Defects / Q000235:genetics; D009925:Organ of Corti / Q000196:embryology*; D000072099:Serrate-Jagged Proteins
chemical_list: D002135:Calcium-Binding Proteins; D017931:DNA Primers; D036341:Intercellular Signaling Peptides and Proteins; C000606274:Jag1 protein, mouse; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; D000072099:Serrate-Jagged Proteins