title: Use of non-invasive positive-pressure ventilation for acute respiratory failure: prospective study.
abstract: OBJECTIVE
  To study the effectiveness and safety of non-invasive positive-pressure ventilation in the management of acute respiratory failure.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Regional public hospital, Hong Kong.
  
  
  METHODS
  One hundred and eighty-nine haemodynamically stable adult Chinese patients with acute respiratory failure (119 men and 70 women; mean age, 71.2 years [range, 18-92 years]) who were treated with non-invasive positive-pressure ventilation as the primary mode of ventilatory assistance from 1 January 1996 to 31 December 1998.
  
  
  METHODS
  Arterial blood gas measurements, respiratory rate, airway pressures used, use of endotracheal intubation, and standardised mortality ratio.
  
  
  RESULTS
  Fifty-two patients had hypoxaemic respiratory failure (group I); 97 had hypercapnic respiratory failure (group II); and 40 had either type with advanced co-morbidities and were not planned to receive endotracheal intubation (group III). For groups I and II, the overall mean duration of non-invasive positive-pressure ventilation was 56.2 hours. Improvements in gas exchange were seen in approximately 71% of these patients, endotracheal intubation was not needed for 82%, and the standardised mortality ratio was 0.86. The hospital survival rate was approximately 93% in non-intubated patients and 41% in intubated patients. Predictors of success were reduction in respiratory rate within 6 hours (P<0.005), and (for hypercapnic respiratory failure) increased pH and reduced arterial carbon dioxide tension within 24 hours (P<0.005). Patients with pneumonia had significantly higher failure rates (P<0.05). Group III patients were older, had higher Acute Physiology and Chronic Health Evaluation II scores, and required longer ventilatory support, but their gas exchange response rate was 68%. The only complication of treatment was minor facial skin abrasions.
  
  
  CONCLUSIONS
  Non-invasive positive-pressure ventilation is effective in treating haemodynamically stable patients with acute respiratory failure and causes few and minor complications.
authors.affiliation: Department of Medicine, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong.
authors.forename: M T
authors.initials: MT
authors.lastname: Cheung
authors.forename: L Y
authors.initials: LY
authors.lastname: Yam
authors.forename: C W
authors.initials: CW
authors.lastname: Lau
authors.forename: C K
authors.initials: CK
authors.lastname: Ching
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007385:Intermittent Positive-Pressure Ventilation; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D012131:Respiratory Insufficiency / Q000628:therapy*; D012449:Safety; D016019:Survival Analysis; D016896:Treatment Outcome