[Association of HLA-DQB1 alleles and the susceptibility to beta-thalassemia in Guangxi Chinese Zhuang nationality].
OBJECTIVE
To investigate the relationship between HLA-DQB1 allele and susceptibility to beta-thalassemia in Guangxi Chinese Zhuang nationality.


METHODS
The polymorphism of the HLA-DQB1 loci in 64 randomly selected, unrelated Guangxi Zhuang individuals with beta-thalassemia was investigated by PCR-SSP.


RESULTS
Compared with normal controls, the frequency of HLA-DQB1*0604 allele was significantly increased in the patient group, with a relative risk(RR) of 9.9(chi 2 = 20.78, P < 0.005), while the frequencies of other HLA-DQB1 alleles did not in the patient group.


CONCLUSIONS
The susceptibility to beta-thalassemia in the Guangxi Zhuang individuals is associated with HLA-DQB1*0604 allele.
Long
G
G
First Affiliated Hospital of Guangxi Medical University, Nanning 530021.
Mohamed
A A
AA
D000328:Adult; D000483:Alleles; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006801:Humans; D008297:Male; D017086:beta-Thalassemia / Q000208:ethnology / Q000235:genetics* / Q000276:immunology
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen