Genetics of anesthetic response: autosomal mutations that render Drosophila resistant to halothane.
Molecular mechanisms of anesthetic action are poorly understood. Genetic approaches to investigate mechanisms of anesthesia, although sparse and rather new, are turning out to be informative and add a new perspective. Before beginning a systematic investigation of anesthesia by this approach, it is necessary to have at hand a large collection of mutations in different loci that alter anesthetic response. We report here the isolation and characterization of six mutant autosomal lines that show a decreased sensitivity to the inhalation of anesthetic halothane. Two of these mutations, Omar(82) and Qajjem(211) are shown to map to separate loci on the third chromosome.
Madhavan
M C
MC
Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400 005, India.
Kumar
R A
RA
Krishnan
K S
KS
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D005824:Genetics, Behavioral / Q000187:drug effects; D006221:Halothane / Q000494:pharmacology*; D008297:Male; D016296:Mutagenesis / Q000187:drug effects* / Q000235:genetics; D010641:Phenotype
D018685:Anesthetics, Inhalation; D006221:Halothane