Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.
Neuroprotective effects of GABA(B) agonist baclofen and GABA(A) agonists THIP and muscimol are completely additive. GABAA and GABA(B) receptor antagonists block the neuroprotective effects of the corresponding agonists without cross-blocking. In fact, the blockade of combined effect of two agonists with selective GABA(A) and GABAB antagonists separately and in combination is not below the estimated value. Therefore, GABA(A) and GABA(B) receptor mechanisms of the neuroprotective effects independently and separately contribute to the improvement of brain resistance to global ischemia.
Kulinskii
V I
VI
Department of Biochemistry, Irkutsk Medical University. kulinsky@pp.irkutsk.ru
Mikhel'son
G V
GV
D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D001640:Bicuculline / Q000008:administration & dosage; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D018755:GABA Agonists / Q000008:administration & dosage; D018756:GABA Antagonists / Q000008:administration & dosage; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D007555:Isoxazoles / Q000008:administration & dosage; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009118:Muscimol / Q000008:administration & dosage; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D010852:Picrotoxin / Q000008:administration & dosage
D001418:Baclofen; D001640:Bicuculline; D018755:GABA Agonists; D018756:GABA Antagonists; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D007555:Isoxazoles; D009118:Muscimol; D018696:Neuroprotective Agents; D010852:Picrotoxin; C015542:gaboxadol; C057491:2-hydroxysaclofen