Persistent paraneoplastic neurologic syndrome after successful therapy of Hodgkin's disease.
Paraneoplastic neurologic syndromes may develop in Hodgkin's disease (HD). We describe three young female patients with neurological disorders, not explained by other causes, preceding diagnosis or relapse of HD. The lack of response of the paraneoplastic syndrome to successful treatment of HD among our three patients emphasizes the poor prognosis of longstanding paraneoplastic neurologic symptoms in HD.
Maslovsky
I
I
Hematology Institute, Barzilai Medical Center, Ashkelon, Israel. igorgn@attglobal.net
Volchek
L
L
Blumental
R
R
Ducach
A
A
Lugassy
G
G
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001259:Ataxia / Q000209:etiology; D001761:Bleomycin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D020275:Guillain-Barre Syndrome / Q000209:etiology*; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008466:Mechlorethamine / Q000008:administration & dosage; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000209:etiology; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D011115:Polyneuropathies / Q000209:etiology; D011241:Prednisone / Q000008:administration & dosage; D011247:Pregnancy; D011344:Procarbazine / Q000008:administration & dosage; D011644:Puerperal Disorders / Q000209:etiology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000209:etiology; D012008:Recurrence; D012021:Reflex, Abnormal; D012678:Sensation Disorders / Q000209:etiology; D014747:Vinblastine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D011241:Prednisone