Synapses call the shots.
Neuroscience research is shedding light on how neurons delegate their protein synthesis, shipping some messenger RNAs out to the dendrites, where they are translated to protein under the control of local synapses. Indeed, it appears that finely controlled, decentralized protein production may contribute to learning and memory in a way that neuroscientists could scarcely have imagined 20 years ago. As researchers presss on, they are filling in a picture of a complex loop of communication and supply, with synapses acting as local managers wielding more power than anyone might have imagined, to get what they need for carrying out the critical task of storing memories.
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D020413:3' Untranslated Regions; D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000096:biosynthesis / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003712:Dendrites / Q000378:metabolism*; D029721:Drosophila Proteins; D005786:Gene Expression Regulation; D007858:Learning / Q000502:physiology*; D017774:Long-Term Potentiation; D008568:Memory / Q000502:physiology*; D009124:Muscle Proteins / Q000096:biosynthesis / Q000235:genetics; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D013569:Synapses / Q000502:physiology*
D020413:3' Untranslated Regions; D029721:Drosophila Proteins; D009124:Muscle Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C069927:stau protein, Drosophila; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases