Prolonged longevity of hypopituitary dwarf mice.
In two types of mutant dwarf mice, congenital deficiencies in pituitary function are associated with remarkably increased life expectancy. In this review, we will describe the key phenotypic characteristics of these animals, the evidence that they exhibit delayed aging, and the mechanisms that are suspected to account for their prolonged longevity.
Bartke
A
A
Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901-6512, USA. abartke@som.siu.edu
Brown-Borg
H
H
Mattison
J
J
Kinney
B
B
Hauck
S
S
Wright
C
C
D000375:Aging; D000818:Animals; D004392:Dwarfism / Q000150:complications* / Q000235:genetics / Q000503:physiopathology*; D007018:Hypopituitarism / Q000150:complications* / Q000503:physiopathology*; D008136:Longevity; D051379:Mice; D010641:Phenotype