Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives.
The effects of imperatorin and its synthetic derivative, Y355, on anti-Fas antibody-induced mice hepatitis were studied. Pretreatment of mice by intraperitoneal administration of imperatorine or Y355 at 30 mg/kg inhibited more than 80% of the anti-Fas antibody (150 microg/kg, i.v.)-induced elevation of plasma alanine aminotransferase activity. Furthermore, oral administration of imperatorin or Y355 at 100 mg/kg also had an inhibitory effect on anti-Fas antibody-induced hepatitis. Both compounds inhibited anti-Fas antibody (250 microg/kg)-induced caspase-1 and caspase-3 activities. The present results showed the inhibition of anti-Fas antibody-induced hepatitis by imperatorin and Y355, which might be a result of inhibition of caspase activities.
Okamoto
T
T
Research Laboratories, Nippon Chemiphar Co., Ltd., 1-22 Hikokawato, Misato, Saitama 341-0005, Japan.
Yoshida
S
S
Kobayashi
T
T
Okabe
S
S
D000410:Alanine Transaminase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000906:Antibodies / Q000187:drug effects / Q000494:pharmacology*; D020170:Caspase 1 / Q000187:drug effects; D053148:Caspase 3; D020169:Caspases / Q000187:drug effects; D005260:Female; D011564:Furocoumarins / Q000008:administration & dosage / Q000494:pharmacology*; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D008099:Liver / Q000201:enzymology; D051379:Mice; D008807:Mice, Inbred BALB C; D019014:fas Receptor / Q000276:immunology*
D000906:Antibodies; D011564:Furocoumarins; D019014:fas Receptor; D000410:Alanine Transaminase; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases; D020170:Caspase 1; C031534:imperatorin