Activity of detoxication enzymes in rat hepatoma 27 transplanted in different organs.
Activities of enzymes of active oxygen forms detoxication and phase II xenobiotic metabolism were measured in rat hepatoma 27 cells transplanted to different organs. Activity of phase II xenobiotic metabolizing enzymes was higher in hepatoma cells growing subcutaneously than in those transplanted into the liver, while activity of active oxygen forms detoxication enzymes (except catalase) was higher in cells transplanted into the liver. Benz(a)pyrene induced the enzyme activities in hepatoma growing both subcutaneously and in the liver.
Ostashkina
N M
NM
Institute of Carcinogenesis, Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
Dubovaya
T K
TK
Koblyakov
V A
VA
Konovalova
G G
GG
Lankin
V Z
VZ
D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000201:enzymology*; D002374:Catalase / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms / Q000201:enzymology*; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D009368:Neoplasm Transplantation; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D004798:Enzymes; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000444:Aldehyde Dehydrogenase; D016660:NAD(P)H Dehydrogenase (Quinone); D005980:Glutathione Reductase; D005982:Glutathione Transferase