[Dose-dependent tazepam modulation of amplitude-temporal characteristics of thalamocortical responses and the constant potential of the sensorimotor cortex in rabbits at eye opening].
The pronounced benzodiazepine (antiphobic) modulation of the amplitude-temporal parameters of different components of the thalamocortical responses (TCR) of the sensorimotor cortex is observed in rabbits in their early postnatal ontogeny. This modulation is of a dose-dependent character and is registered not after the injection of tazepam in a concentration of the "therapeutic tranquilizing window" but also in the psychotoxic plasma range. A gradual increase in blood tazepam concentration in a young rabbit pup is accompanied by the wave-like and differential decrease in the amplitude of the second and third positive (P2 and P3) and third negative (N3) TCR components, while the second negative (N2) and fourth positive (P4) components tend to a wave-like increase. The dose-dependent dynamics of tazepam modulation of the P2, P3, and N3 latencies is characterized by a wave-like and differential increase. The latency of P4 decreases slightly and that of the N2 increases with a low degree of significance. The selective dynamics of benzodiazepine modulation appears to be related with peculiarities of the electrogenesis of each of the components. The dose-dependent modulation of the level of cortical DC potential is of the same character as the respective amplitude changes in P2, P3, and N3, but its fluctiatuons are more pronounced.
Shimko
I A
IA
Brain Research Institute, Russian Academy of Medical Sciences, Moscow.
Fokin
V F
VF
D000818:Animals; D000831:Animals, Newborn; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000254:growth & development / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000254:growth & development; D008297:Male; D008564:Membrane Potentials; D009044:Motor Cortex / Q000254:growth & development / Q000502:physiology*; D010076:Oxazepam / Q000494:pharmacology*; D011817:Rabbits; D011930:Reaction Time; D013003:Somatosensory Cortex / Q000254:growth & development / Q000502:physiology*; D013788:Thalamus / Q000254:growth & development / Q000502:physiology*
D014151:Anti-Anxiety Agents; D010076:Oxazepam