Similarities and differences between free 211At and 125I- transport in porcine thyroid epithelial cells cultured in bicameral chambers.
The transport and accumulation of free 211At and 125I- were investigated in thyrocytes cultured as monolayers in bicameral chambers under the influence of thyroid-stimulating hormone, stable iodide, ouabain and perchlorate. The results indicate that there are similarities and differences in the transport mechanisms of free 211At and 125I-. These results will be valuable in the development of radiation protection when handling and using 211At-labeled radiopharmaceuticals, and for the potential use of free 211At in radiation therapy of poorly differentiated thyroid cancer.
Lindencrona
U
U
Department of Radiation Physics, Göteborg University, Sahlgrenska University Hospital, SE-413 45, Göteborg, Sweden. ulrika.lindencrona@radfys.gu.se
Nilsson
M
M
Forssell-Aronsson
E
E
D000818:Animals; D001246:Astatine / Q000493:pharmacokinetics*; D001692:Biological Transport / Q000187:drug effects; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics*; D010042:Ouabain / Q000494:pharmacology; D010472:Perchlorates / Q000494:pharmacology; D017670:Sodium Compounds / Q000494:pharmacology; D013552:Swine; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology
D004791:Enzyme Inhibitors; D007457:Iodine Radioisotopes; D010472:Perchlorates; D017670:Sodium Compounds; D010042:Ouabain; D013972:Thyrotropin; C031068:sodium perchlorate; D001246:Astatine