Urinary levels of interleukin-8 (IL-8) and disease activity in patients with IgA nephropathy.
Using quantitative sandwich ELISA, we studied 27 patients with IgA nephropathy to determine whether the levels of urinary IL-8 might reflect the disease activity. The levels of urinary IL-8 in patients with advanced stage IgA nephropathy were significantly higher than those in the patients with the mild stage of this disease, or in the healthy controls. The results showed a positive significant correlation between the levels of IL-8 and disease activity, i.e., between levels of urinary protein and urinary casts. A significant correlation between levels of urinary IL-8 and tubular function damage was also found. It was thus suggested that measurement of urinary IL-8 might be useful in evaluating the degree of renal injuries and/or prognosis in patients with IgA nephropathy.
Huang
F
F
Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Horikoshi
S
S
Kurusu
A
A
Shibata
T
T
Suzuki
S
S
Funabiki
K
K
Shirato
I
I
Tomino
Y
Y
D000328:Adult; D003404:Creatinine / Q000097:blood / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005922:Glomerulonephritis, IGA / Q000652:urine*; D006801:Humans; D016209:Interleukin-8 / Q000652:urine*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011507:Proteinuria; D012016:Reference Values; D014556:Urine / Q000166:cytology
D016209:Interleukin-8; D003404:Creatinine