title: Aging research. Old flies may hold secrets of aging.
abstract: On page 2137, a research team reports the discovery of a gene that, when altered, can double the life-span of fruit flies and may one day offer the promise of perpetual youth. Preliminary data suggest that the protein encoded by this gene transports and recycles metabolic byproducts. The researchers think that defects in the gene can lead to production of a protein that renders metabolism less efficient; as a result the body functions as if the fruit fly were dieting, even though its eating habits are unchanged. The work may lead to a better understanding of how metabolism plays into aging.
authors.forename: E
authors.initials: E
authors.lastname: Pennisi
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D029382:Dicarboxylic Acid Transporters; D004064:Digestive System / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D005216:Fat Body / Q000378:metabolism; D017344:Genes, Insect; D008136:Longevity / Q000235:genetics*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D009154:Mutation; D029363:Organic Anion Transporters, Sodium-Dependent; D027981:Symporters
chemical_list: D002352:Carrier Proteins; D029382:Dicarboxylic Acid Transporters; D029721:Drosophila Proteins; C417606:Indy protein, Drosophila; D008565:Membrane Proteins; D029363:Organic Anion Transporters, Sodium-Dependent; C092524:SLC13A2 protein, human; D027981:Symporters