Azithromycin and gentamicin therapy for the treatment of humans with brucellosis.
Ten patients with brucellosis were treated with azithromycin and gentamicin to assess the treatment's safety and efficacy. Seven patients had an excellent therapeutic response at the end of therapy; however, relapse was noted in 3. When relapse was considered in combination with an initial lack of efficacy, 5 patients (50%; 95% confidence interval, 18.7%-81.3%) did not respond to therapy; these results do not favor the use of azithromycin to treat brucellosis in humans.
Solera
J
J
Unit of Infectious Diseases, Service of Internal Medicine, Hospital General, Albacete, Spain. jsolera@chospab.es
Beato
J L
JL
Martínez-Alfaro
E
E
Segura
J C
JC
de Tomas
E
E
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017963:Azithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D002006:Brucellosis / Q000188:drug therapy*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012449:Safety; D017211:Treatment Failure; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D017963:Azithromycin