Current status and perspectives in clinical islet transplantation.
Beta-cell replacement, by either pancreas or islet transplantation, is the only treatment to achieve an insulin-independent, constantly normoglycemic state avoiding hypoglycemic episodes in patients with type-1 diabetes mellitus. This article reviews the current state of the worldwide experience based on data provided by the International Islet Transplant Registry; it also illustrates the perspectives of clinical islet transplantation.
Bretzel
R G
RG
Third Medical Department, Justus-Liebig-University, Rodthohl 6, D-35392 Giessen, Germany.
D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery; D006085:Graft Survival; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000276:immunology; D016035:Pancreas Transplantation; D014184:Transplantation, Homologous