title: TT virus levels in the plasma of infected individuals with different hepatic and extrahepatic pathology.
abstract: TT virus (TTV) infection is extremely widespread in the general population. A sensitive real-time PCR assay was developed that quantitated accurately the most prevalent TTV genotypes in Italy. When used to test 217 individuals for TTV viraemia, the overall prevalence was 94%. Viraemia levels varied widely amongst individual subjects, with no major differences related to gender or age. The highest TTV titres were in haemophiliacs and in patients with non-A-E hepatitis, but they did not differ from the group with miscellaneous diseases. HIV- and HCV-infected subjects and patients with primary liver diseases had TTV loads similar to those of healthy individuals.
authors.affiliation: Virology Section and Retrovirus Centre, Department of Biomedicine, University of Pisa, Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pistello
authors.forename: A
authors.initials: A
authors.lastname: Morrica
authors.forename: F
authors.initials: F
authors.lastname: Maggi
authors.forename: M L
authors.initials: ML
authors.lastname: Vatteroni
authors.forename: G
authors.initials: G
authors.lastname: Freer
authors.forename: C
authors.initials: C
authors.lastname: Fornai
authors.forename: F
authors.initials: F
authors.lastname: Casula
authors.forename: S
authors.initials: S
authors.lastname: Marchi
authors.forename: P
authors.initials: P
authors.lastname: Ciccorossi
authors.forename: P
authors.initials: P
authors.lastname: Rovero
authors.forename: M
authors.initials: M
authors.lastname: Bendinelli
mesh_terms: D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D017931:DNA Primers; D004266:DNA Virus Infections / Q000150:complications / Q000821:virology*; D006467:Hemophilia A / Q000150:complications / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000821:virology; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000821:virology*; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D022783:Torque teno virus / Q000235:genetics / Q000302:isolation & purification*; D019562:Viral Load; D014766:Viremia
chemical_list: D017931:DNA Primers