Behavioral peculiarities and reactions of brain dopaminergic systems in rats with different resistance to acute hypobaric hypoxia.
Locomotor activity in the open field test did not correlate with rat resistance to acute hypobaric hypoxia; there was a correlation between this resistance and rat behavior during acute stress. Immobility was characteristic of rats with low and particularly medium resistance to hypoxia; this reaction can be abolished by antidepressants. by contrast, highly resistant rats were mainly hyperactive. The resistance to hypoxia was associated with extreme parameters of dopaminergic neuron functioning. In low-resistant rats locomotor stereotypia was maximal, while perioral stereotypia was the minimal; highly resistant rats were characterized by an opposite pattern, and medium-resistant rats occupied an intermediate position.
Bondarenko
N A
NA
Laboratory of Bioenergetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Germanova
E L
EL
Luk'yanova
L D
LD
D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004924:Escape Reaction; D000860:Hypoxia / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*
D011954:Receptors, Dopamine; D004298:Dopamine