title: Mitochondrial dysfunction and neuromuscular disease.
abstract: Mitochondrial diseases are a heterogeneous group of disorders with widely varying clinical features, due to defects in mitochondrial function. Involvement of both muscle and nerve is common in mitochondrial disease. In some cases, this involvement is subclinical or a minor part of a multisystem disorder, but myopathy and neuropathy are a major, often presenting, feature of a number of mitochondrial syndromes. In addition, mitochondrial dysfunction may play a role in a number of classic neuromuscular diseases. This article reviews the role of mitochondrial dysfunction in neuromuscular disease and discusses a rational approach to diagnosis and treatment of patients presenting with a neuromuscular syndrome due to mitochondrial disease.
authors.affiliation: Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Harvard Institute of Medicine, Rm 858, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Nardin
authors.forename: D R
authors.initials: DR
authors.lastname: Johns
mesh_terms: D006801:Humans; D017240:Mitochondrial Myopathies / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D009468:Neuromuscular Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy