title: Expression of cyclin E and cyclin D1 in non-small cell lung cancers.
abstract: The relationships between overexpression of cyclin D1 or cyclin E and clinicopathological factors were investigated in 157 patients with non-small cell lung cancers (NSCLCs) using immunohistochemical analysis. Fifty-eight cases of NSCLCs (58/157, 37%) showed the overexpression of cyclin D1, and 64 cases (64/157, 41%) were positive for cyclin E. Cyclin E and cyclin D1 were infrequently concurrently overexpressed (17/157, 10.8%). Overexpression of cyclin E was more frequently observed in squamous cell carcinoma (29/57, 51%) compared with that in adenocarcinoma (28/86, 33%) (P<0.05). In addition, overexpression of cyclin E was more frequently observed in poorly or moderately differentiated NSCLCs (52/103, 50%) than in well-differentiated ones (12/54, 22%) regardless of their histological types (P<0.01). On the contrary, there was no statistically significant relationship between cyclin D1 overexpression and histological types or grade of tumor differentiation. These findings suggest that expression of cyclin E was frequently independent of that of cyclin D1 and played some roles in the grade of tumor differentiation in NSCLCs.
authors.affiliation: Department of Pathology II, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamanouchi
authors.forename: M
authors.initials: M
authors.lastname: Furihata
authors.forename: J
authors.initials: J
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Yoshinouchi
authors.forename: J
authors.initials: J
authors.lastname: Takahara
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry* / Q000503:physiopathology; D002471:Cell Transformation, Neoplastic; D019938:Cyclin D1 / Q000096:biosynthesis*; D019927:Cyclin E / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
chemical_list: D019927:Cyclin E; D019938:Cyclin D1