title: Rhabdomyolysis and acute renal failure after changing statin-fibrate combinations.
abstract: Statin-fibrate combinations are commonly used to treat hyperlipidemia. These drugs have been previously reported to cause rhabdomyolysis with acute renal failure. Whether different statin-fibrate combinations have different risks for rhabdomyolysis is not known. We report a patient who developed rhabdomyolysis with acute renal failure promptly after switching from the combination of pravastatin and fenofibrate to simvastatin and gemfibrozil.
authors.affiliation: Department of Internal Medicine, Creighton University, Omaha, NE, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Oldemeyer
authors.forename: R J
authors.initials: RJ
authors.lastname: Lund
authors.forename: M
authors.initials: M
authors.lastname: Koch
authors.forename: A J
authors.initials: AJ
authors.lastname: Meares
authors.forename: R
authors.initials: R
authors.lastname: Dunlay
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D011345:Fenofibrate / Q000627:therapeutic use; D015248:Gemfibrozil / Q000009:adverse effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D000960:Hypolipidemic Agents / Q000009:adverse effects*; D008297:Male; D017035:Pravastatin / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000139:chemically induced*; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D019821:Simvastatin; D017035:Pravastatin; D015248:Gemfibrozil; D011345:Fenofibrate