title: [Value of hematopoietic stem cell autotransplantation in the treatment of multiple myeloma: initial experience at the National Bone Marrow Transplantation Center and review of the literature].
abstract: Alkylating agents administered with predisone have been the standard therapy for myeloma over the lost three decades. Intensive treatment with autologous hematopoietic support has become the treatment of choice for multiple myeloma patients up to 60 years of age. From march 1999 to january 2000, seven patients with multiple myeloma (stage III) with a median age of 43 years (34-56) received an autologous stem cell transplantation. The myeloablative treatment regimen consisted of high-dose melphalan. All patients had sustained engraftment. The median duration of neutropenia (< 500/mm3) was 12 days (11-140) and the median duration of thrombocytopenia (< 20,000/mm3) was 13 days (11-110). One patient had a complete remission, one a very good partial remission, and 5 patients had a partial remission. With a median follow-up of 8 months (2-12), all patients are alive, without relapse.
authors.affiliation: Centre National de Greffe de Moelle Osseuse, Tunis.
authors.forename: A
authors.initials: A
authors.lastname: Abdelkefi
authors.forename: S
authors.initials: S
authors.lastname: Ladeb
authors.forename: T
authors.initials: T
authors.lastname: Ben Othman
authors.forename: L
authors.initials: L
authors.lastname: Torjman
authors.forename: R
authors.initials: R
authors.lastname: Jeddi
authors.forename: A
authors.initials: A
authors.lastname: Ben Abdeladhim
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008297:Male; D008558:Melphalan / Q000627:therapeutic use*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D009503:Neutropenia / Q000209:etiology; D012074:Remission Induction / Q000379:methods; D013921:Thrombocytopenia / Q000209:etiology; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods; D014182:Transplantation, Autologous / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome; D014416:Tunisia
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan