Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230.
The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. Some of the prepared cyclitol derivatives (i.e. 9, 11, 12, and 14) proved to be very powerful and specific irreversible inhibitors of PI4K230 at or below a concentration of 1 mM.
Pelyvás
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IF
Research Group of Antibiotics of the Hungarian Academy of Sciences, University of Debrecen, P.O. Box 70, Debrecen H-4010, Hungary. antibiotics@tigris.klte.hu
Tóth
Z G
ZG
Vereb
G
G
Balla
A
A
Kovács
E
E
Gorzsás
A
A
Sztaricskai
F
F
Gergely
P
P
D000818:Animals; D002417:Cattle; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013402:Sugar Alcohols / Q000138:chemical synthesis* / Q000737:chemistry
D003512:Cyclohexanones; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D013402:Sugar Alcohols; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase