Involvement of central and peripheral cannabinoid receptors in the regulation of heart resistance to arrhythmogenic effects of epinephrine.
Intravenous injection of the selective cannabinoid receptor agonist HU-210 in doses of 0.05 and 0.25 mg/kg increased heart resistance to arrhythmogenic effects of epinephrine, while intracerebroventricular infusion of this substance had no effect on the incidence of epinephrine-induced arrhythmia. The selective antagonist of type I cannabinoid receptors SR141716A in a dose of 3 mg/kg and ganglion blocker hexamethonium in a dose of 10 mg/kg did not modify the antiarrhythmic effect of HU-210. This effect of HU-210 is probably related to activation of type II peripheral cannabinoid receptors.
Ugdyzhekova
D S
DS
Tomsk State Pedagogical University, Russia.
Davydova
Y G
YG
Maimeskulova
L A
LA
Mechoulam
R
R
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000378:metabolism*; D002186:Cannabinoids / Q000819:agonists / Q000037:antagonists & inhibitors; D004195:Disease Models, Animal; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D005730:Ganglionic Blockers / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D018738:Hexamethonium / Q000494:pharmacology; D007113:Immunity, Innate; D010880:Piperidines / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000378:metabolism*; D000077285:Rimonabant
D002186:Cannabinoids; D005730:Ganglionic Blockers; D010880:Piperidines; D011720:Pyrazoles; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D018738:Hexamethonium; D013759:Dronabinol; C062018:HU 211; D000077285:Rimonabant; D004837:Epinephrine