title: [The role of L-3-I-123-iodine-alpha-methyltyrosine SPECT in cerebral gliomas].
abstract: L-3-I-123-iodine-alpha-methyltyrosine (IMT) is a I-123-labelled amino acid which has been used for single photon emission computed tomography (SPECT) of cerebral gliomas for more than a decade. IMT-SPECT is able to detect tumor infiltration independent of disruptions of the blood-brain barrier which is often difficult with computed tomography or magnetic resonance tomography. The method is useful to detect tumor recurrences and helps to distinguish gliomas from non-neoplastic brain masses. IMT-SPECT is thus a valuable tool in the diagnostic evaluation and in therapy planning of patients with cerebral gliomas.
authors.affiliation: Klinik und Poliklinik für Nuklearmedizin, Universität Münster.
authors.forename: M
authors.initials: M
authors.lastname: Weckesser
authors.forename: D
authors.initials: D
authors.lastname: Schmidt
authors.forename: P
authors.initials: P
authors.lastname: Matheja
authors.forename: H H
authors.initials: HH
authors.lastname: Coenen
authors.forename: K J
authors.initials: KJ
authors.lastname: Langen
mesh_terms: D001812:Blood-Brain Barrier; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005910:Glioma / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D008781:Methyltyrosines; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D019275:Radiopharmaceuticals; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007457:Iodine Radioisotopes; D008781:Methyltyrosines; D019275:Radiopharmaceuticals; C030855:3-iodo-alpha-methyltyrosine