title: [Mechanism f kidney participation in maintaining osmotic and ion homeostasis in chronic renal failure].
abstract: In examination of patients with chronic renal failure (CRF) at glomerular filtration rate below 30 ml/min and blood serum ion concentration within limits of normal values hyperosmia has been found. Under the natural regimen essential differences have been revealed neither in variation limits of renal excretion of ions nor osmotically active substances in CRF patients as compared with healthy controls. Diuresis correlated with renal excretion of osmotically active substances. It is shown that a decrease in reabsorption of osmotically active substances depends on secretion and excretion of prostaglandin E2. A suggestion is made about the role of prostaglandins in regulation of renal tubular function at terminal CRF stages.
authors.forename: A E
authors.initials: AE
authors.lastname: Bogolepova
authors.forename: A A
authors.initials: AA
authors.lastname: Kuznetsova
authors.forename: B G
authors.initials: BG
authors.lastname: Lukichev
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Natochkin
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Parshukova
authors.forename: N P
authors.initials: NP
authors.lastname: Prutskova
authors.forename: E I
authors.initials: EI
authors.lastname: Shakhmatova
mesh_terms: D000293:Adolescent; D000328:Adult; D018450:Disease Progression; D004231:Diuresis; D005260:Female; D005919:Glomerular Filtration Rate; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000503:physiopathology; D007684:Kidney Tubules / Q000378:metabolism; D008274:Magnesium / Q000097:blood / Q000652:urine; D008297:Male; D009995:Osmosis; D012720:Severity of Illness Index; D012964:Sodium / Q000097:blood / Q000652:urine
chemical_list: D012964:Sodium; D008274:Magnesium