Variant-specific surface protein switching in Giardia lamblia.
Surface antigen switching in Giardia lamblia was analyzed using monoclonal antibodies specific for two variant-specific surface proteins (VSPs). Two VSPs were detected on the surface of single trophozoites. Dual expression persisted for 13 h but disappeared at 36 h, as in other parasites that undergo surface antigenic variation.
Nash
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Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. tnash@niaid.nih.gov
Luján
H T
HT
Mowatt
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MR
Conrad
J T
JT
D000818:Animals; D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000940:Antigenic Variation; D000953:Antigens, Protozoan / Q000235:genetics*; D000954:Antigens, Surface / Q000235:genetics*; D016829:Giardia lamblia / Q000235:genetics / Q000276:immunology*; D015800:Protozoan Proteins
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D015800:Protozoan Proteins; C072464:variant surface protein H7, Giardia lamblia