title: Dermatofibroma-like granular cell tumor.
abstract: BACKGROUND
  There have been several reports in the literature of dermatofibromas with granular cells. Here we report a granular cell tumor with the architecture of a dermatofibroma. This is the first report of this histological variant of granular cell tumor. The lesion was a 2.5-cm oval, hyperpigmented plaque present for "years" on the back of a 60-year-old African-American woman.
  
  
  METHODS
  The specimen was processed using formalin fixation and paraffin embedding. Tissue sections were stained with hematoxylin and eosin. Immunohistochemical studies were performed with antibodies directed against S-100 protein, neuron-specific enolase, and factor XIIIa.
  
  
  RESULTS
  Histopathologic examination revealed granular cells, some of which were spindle shaped, distributed singly and in small groups between collagen bundles resembling a dermatofibroma. Immunohistochemical studies showed the tumor cells to be positive for S-100 and neuron-specific enolase and negative for factor XIIIa.
  
  
  CONCLUSIONS
  The immunohistochemical findings support the diagnosis of a granular cell tumor with a dermatofibroma-like pattern.
authors.affiliation: The Ohio State University, University Medical Center, Columbus, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Cheng
authors.forename: A S
authors.initials: AS
authors.lastname: Usmani
authors.forename: B R
authors.initials: BR
authors.lastname: DeYoung
authors.forename: M
authors.initials: M
authors.lastname: Ly
authors.forename: A E
authors.initials: AE
authors.lastname: Pellegrini
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D011503:Transglutaminases / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D009418:S100 Proteins; D011503:Transglutaminases; D010751:Phosphopyruvate Hydratase