Chromosomal changes in a dedifferentiated chondrosarcoma: a case report and review of the literature.
The chromosome abnormalities observed in a dedifferentiated chondrosarcoma are reported. A new molecular cytogenetic technique, spectral karyotyping, was used to identify and confirm structural rearrangements in this case. A review of the literature revealed that nine cases have been reported, in eight of which a complete description of the cytogenetic abnormalities was described. Structural aberrations were most frequently reported in chromosomes 1 and 9, and chromosomes 7 and 19 were most frequently observed to be involved in numerical aberrations (trisomy and tetrasomy). In chondrosarcomas, structural aberrations in chromosomes 1 and 9 and trisomy or tetrasomy of chromosome 7 are among the more frequently observed aberrations.
O'Malley
D P
DP
Department of Pathology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Opheim
K E
KE
Barry
T S
TS
Chapman
D B
DB
Emond
M J
MJ
Conrad
E U
EU
Norwood
T H
TH
D019645:Arthroplasty, Replacement, Knee; D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002869:Chromosome Aberrations; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005266:Femoral Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged