[Laryngeal amyloidosis: a rare cause of hoarseness].
BACKGROUND
The larynx is a rare site of deposition for amyloidosis. Diagnosis may be delayed and evoked in patients with prolonged hoarseness. We have reported two cases of laryngeal amyloidosis.


METHODS
One man and one woman suffered from hoarseness during one and three years, respectively. Laryngoscopic examination showed diffuse infiltration of the larynx. Amyloidosis was confirmed by the characteristic Congo-red staining of laryngeal biopsies. The search for other localizations of amyloidosis was negative. No monoclonal plasma cell proliferation was detected. Both patients received endoscopic CO2 laser excision. In one case, chemotherapy was initially associated due to dystrophic plasma cells in bone marrow aspiration and then withdrawn because of clinical failure. With a 6-month follow-up, hoarseness remained stable.


CONCLUSIONS
Laryngeal amyloidosis is an essentially localized disease revealed by hoarseness. Treatment is endoscopic by laser excision. In nearly half of the cases in the literature, it had to be repeated due to localized recurrent lesions. Long-term prognosis of localized laryngeal amyloidosis is better than systemic AL amyloidosis.
Vignes
S
S
Service de médecine interne, hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75571 Paris, France.
Brasnu
D
D
Hénégar
C
C
Tiev
K P
KP
Généreau
T
T
Cabane
J
J
D000686:Amyloidosis / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D001706:Biopsy; D005260:Female; D006685:Hoarseness / Q000209:etiology*; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged