title: Regulation of matrix metalloproteinase expression in endothelial cells by heat-inactivated Streptococcus pneumoniae.
abstract: Matrix metalloproteinases (MMPs) may contribute to an impaired endothelial layer in several diseases. We examined the effect of heat-inactivated Streptococcus pneumoniae R6 on MMP-2 and MMP-9 release by cultured aortic and brain capillary endothelial cells. Treatment with heat-inactivated S. pneumoniae caused an increased release of MMP-2 by both cell types.
authors.affiliation: Neurobiologisches Labor, Neurologische und Psychiatrische Klinik, 37075 Göttingen, Germany. umichel@gwdg.de
authors.forename: U
authors.initials: U
authors.lastname: Michel
authors.forename: R
authors.initials: R
authors.lastname: Zobotke
authors.forename: M
authors.initials: M
authors.lastname: Mäder
authors.forename: R
authors.initials: R
authors.lastname: Nau
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology*; D015971:Gene Expression Regulation, Enzymologic; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis; D020782:Matrix Metalloproteinases / Q000096:biosynthesis*; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000472:pathogenicity*; D013552:Swine; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D013755:Tetradecanoylphorbol Acetate