title: [76Br]Bromodeoxyuridine PET in tumor-bearing animals.
abstract: 5-bromodeoxyuridine (BUdR) provides in vitro measures of tumor cell proliferation. We used positron emission tomography to study tissue and plasma kinetics of [76Br]BUdR in tumor-bearing animals. In order to account for the slow washout of the major plasma metabolite, [76Br]bromide, a mathematical correction for the distribution volume of [76Br]bromide was applied. However, following correction specific tumor tracer retention was low or even zero and did not correlate with independent measures of proliferation. The kinetic characteristics of [76Br]BUdR make this tracer unsuitable for proliferation imaging.
authors.affiliation: Section of Diagnostic Imaging, Veterinary School, University of Zurich, 8057, Zürich, Switzerland.
authors.forename: O
authors.initials: O
authors.lastname: Gardelle
authors.forename: U
authors.initials: U
authors.lastname: Roelcke
authors.forename: P
authors.initials: P
authors.lastname: Vontobel
authors.forename: N E
authors.initials: NE
authors.lastname: Crompton
authors.forename: I
authors.initials: I
authors.lastname: Guenther
authors.forename: P
authors.initials: P
authors.lastname: Bläuenstein
authors.forename: A P
authors.initials: AP
authors.lastname: Schubiger
authors.forename: H
authors.initials: H
authors.lastname: Blattmann
authors.forename: J E
authors.initials: JE
authors.lastname: Ryser
authors.forename: K L
authors.initials: KL
authors.lastname: Leenders
authors.forename: B
authors.initials: B
authors.lastname: Kaser-Hotz
mesh_terms: D000818:Animals; D001967:Bromine Radioisotopes / Q000097:blood; D001973:Bromodeoxyuridine / Q000097:blood / Q000493:pharmacokinetics*; D002415:Cats; D004285:Dogs; D005260:Female; D005434:Flow Cytometry; D006207:Half-Life; D008297:Male; D008433:Mathematics; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D001967:Bromine Radioisotopes; D011838:Radiation-Sensitizing Agents; D001973:Bromodeoxyuridine