The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites.
Several vertebrate genes of the Hairy/Enhancer-of-split (HES) family are involved in paraxial mesoderm segmentation and intersomitic boundary establishment/maintenance. Here, we show that the zebrafish hairy-related gene, her6, highly homologous to the mammalian and chicken HES-1 genes, is expressed in the posterior part of each segmented somite and in stripes in the anterior presomitic mesoderm (PSM), and also in a dynamic, segmentally restricted pattern during hindbrain segmentation, with all rhombomeres expressing her6 at different time points and at different levels.
Pasini
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Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK.
Henrique
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Wilkinson
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D001921:Brain / Q000196:embryology*; D002645:Chickens; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D004625:Embryo, Nonmammalian; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D012097:Repressor Proteins / Q000096:biosynthesis* / Q000235:genetics*; D012249:Rhombencephalon / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D019170:Somites / Q000378:metabolism*; D013997:Time Factors; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics*; D014981:Xenopus; D015027:Zebrafish; D029961:Zebrafish Proteins
D051792:Basic Helix-Loop-Helix Proteins; D018076:DNA, Complementary; D012097:Repressor Proteins; D014157:Transcription Factors; D029961:Zebrafish Proteins; C426854:Her6 protein, zebrafish