Protein design based on folding models.
The basic rules governing the folding of small, single-domain proteins are being discovered. New algorithms that can predict the major features of the folding process give the opportunity to design and optimise protein folding in a rational way. Recent experimental works suggest that sequence-specific features should be integrated in folding models to improve their performance.
Guerois
R
R
European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg D-69117, Germany. guerois@embl-heidelberg.de
Serrano
L
L
D000465:Algorithms; D003198:Computer Simulation; D008956:Models, Chemical; D008958:Models, Molecular; D015202:Protein Engineering / Q000379:methods*; D017510:Protein Folding