title: The inhibition of fatty acid elongation by pebulate can be effectively counteracted by the safener dichlormid.
abstract: The thiocarbamate herbicide pebulate inhibits fatty acid elongation, which is necessary for surface lipid biosynthesis. As both barley and wild oats are susceptible to pebulate, the safener dichlormid was used to study the reversal of its herbicidal effect. Fatty acid elongation was restored by a dichlormid pretreatment in barley, but not in pebulate-expressed oats.
authors.affiliation: Cardiff School of Biosciences, Cardiff University, P.O. Box 911, Cardiff CF10 3US, UK.
authors.forename: A
authors.initials: A
authors.lastname: Baldwin
authors.forename: D
authors.initials: D
authors.lastname: Francis
authors.forename: H J
authors.initials: HJ
authors.lastname: Rogers
authors.forename: J L
authors.initials: JL
authors.lastname: Harwood
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000085:Acetates / Q000378:metabolism; D000123:Acetyltransferases / Q000378:metabolism*; D018554:Avena / Q000187:drug effects / Q000378:metabolism*; D002250:Carbon Radioisotopes; D000081031:Fatty Acid Elongases; D005227:Fatty Acids / Q000096:biosynthesis*; D005230:Fatty Acids, Nonesterified / Q000096:biosynthesis; D006540:Herbicides / Q000494:pharmacology; D001467:Hordeum / Q000187:drug effects / Q000378:metabolism*; D018520:Plant Shoots / Q000378:metabolism; D013859:Thiocarbamates / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D000081:Acetamides; D000085:Acetates; D002250:Carbon Radioisotopes; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D006540:Herbicides; D013859:Thiocarbamates; C006284:dichlormid; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases; C017605:pebulate