PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate.
Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver. This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes. Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology. Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.
Okar
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Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Manzano
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Navarro-Sabatè
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Riera
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Bartrons
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Lange
A J
AJ
D000818:Animals; D003920:Diabetes Mellitus / Q000628:therapy; D019143:Evolution, Molecular; D005544:Forecasting; D005635:Fructosediphosphates / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D025481:Phosphofructokinase-2; D010744:Phosphoric Monoester Hydrolases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011487:Protein Conformation
D005635:Fructosediphosphates; D007527:Isoenzymes; C027652:fructose 2,6-diphosphate; D025481:Phosphofructokinase-2; D010744:Phosphoric Monoester Hydrolases