Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.
The chronological accumulation of mitochondrial dysfunction has been proposed as a potential mechanism in the physiological processes of aging. Cytochrome c oxidase deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders. We show that there is an age-related increase in cytochrome c oxidase-deficient cells in both hippocampal pyramidal neurons and choroid plexus epithelial cells. We suggest that these cells contribute to the cell death and dysfunction in CNS aging.
Cottrell
D A
DA
Department of Neurology, The Medical School, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK. d.a.cottrell@ncl.ac.uk
Blakely
E L
EL
Johnson
M A
MA
Ince
P G
PG
Borthwick
G M
GM
Turnbull
D M
DM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002831:Choroid Plexus / Q000166:cytology / Q000378:metabolism*; D030401:Cytochrome-c Oxidase Deficiency; D004272:DNA, Mitochondrial / Q000235:genetics; D004847:Epithelial Cells / Q000201:enzymology; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011180:Postmortem Changes; D017966:Pyramidal Cells / Q000201:enzymology; D013385:Succinate Dehydrogenase / Q000378:metabolism
D004272:DNA, Mitochondrial; D013385:Succinate Dehydrogenase