Enantioselective addition of a chiral thiazolidinethione-derived titanium enolate to acetals.
[reaction: see text] High stereoselectivities (up to 98% de) have been achieved for the Lewis acid-mediated cross-coupling reaction of dimethyl acetals to a chiral 1,3-thiazolidine-2-thione-derived titanium enolate. The reaction affords enantiopure anti alpha-methyl-beta-alkoxy carbonyl compounds in a wide range of acetals.
Cosp
A
A
Departaments de Química Orgànica and Cristal.lografia, Mineralogia i Dipòsits Minerals, Universitat de Barcelona, Catalonia, Spain.
Romea
P
P
Talavera
P
P
Urpí
F
F
Vilarrasa
J
J
Font-Bardia
M
M
Solans
X
X