title: Mixed connective tissue disease following interstitial cystitis.
abstract: A 64-year-old woman complained of severe infrapubic pain and pollakisuria with nausea, vomiting and diarrhea, but with normal urinalysis since 1987. The clinical diagnosis of interstitial cystitis (IC) was made, and cystectomy was performed in 1996. The bladder taken was markedly shrunken with a capacity of 50 ml, and showed bleeding on the mucosal surface. Histological findings of the bladder showed ulcer formation in the mucous membrane, and marked infiltration of mononuclear cells, edema and fibrosis in the submucosal tissue. She had noticed exudative erythema, swelling and sclerosis on the bilateral fingers and dorsal aspects of the hands since 1993, and Raynaud's phenomenon and morning stiffness of the fingers from November, 1998. Laboratory data showed positive anti-nuclear antibody (titer: 1: 2,560) and anti-U1 RNP antibody (titer: 69.5 by ELISA). A diagnosis of mixed connective tissue disease following IC was made.
authors.affiliation: Department of Dermatology, Ogaki Municipal Hospital, Minaminokawa-cho, 4-86, Ogaki, 503-8502, Japan. seimarik@gifu-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Seishima
authors.forename: H
authors.initials: H
authors.lastname: Shimizu
authors.forename: Z
authors.initials: Z
authors.lastname: Oyama
authors.forename: K
authors.initials: K
authors.lastname: Isogai
mesh_terms: D015653:Cystectomy; D018856:Cystitis, Interstitial / Q000150:complications / Q000601:surgery*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000175:diagnosis*