[Pulmonary complications occurring after allogeneic bone marrow transplantation].
OBJECTIVE
To explore the risk factors for and pathogenesis of pulmonary complications (PC) occurred after allogeneic bone marrow transplantation (allo-BMT).


METHODS
The PC in 185 patients undergone allo-BMT were analyzed.


RESULTS
Ninety-three PC episodes were observed in 89 patients and most of them were due to infections, including bacterial pneumonia (n = 27), interstitial pneumonia (n = 7), pulmonary fungus disease (n = 16), tuberculosis (n = 4), obstructive lung disease (n = 2), pulmonary edema (n = 2), lung abscess (n = 1) and 34 episodes caused by two or more pathogens. The overall mortality for PC was 12.43% (23/185).


CONCLUSIONS
The risk factors for PC occurred after allo-BMT were not related to age and sex of recipients, bone marrow status before BMT, conditioning regimen and pulmonary function. Graft-versus-host-disease significantly increased the morbidity and mortality of PC after allo-BMT.
Fan
Y
Y
Institute of Hematology, People's Hospital, Beijing Medical University, Beijing 100044.
Guo
N
N
Huang
X
X
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D005260:Female; D006086:Graft vs Host Disease; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008172:Lung Diseases, Fungal / Q000209:etiology*; D017563:Lung Diseases, Interstitial / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000209:etiology*; D019172:Transplantation Conditioning / Q000379:methods