[Endocrine disrupter and reproductive disorders in women].
Endocrine disrupters, which are exogenous substances with estrogenic or other hormonally active properties, may adversely affect the reproductive health of both women and men. The resulting disorders can include cancer development in hormonally sensitive tissues, structural alteration of reproductive organs, and delay or acceleration of the estrus cycle. However, the available laboratory and epidemiological data do not provide consistent or convincing evidence that industrial chemicals suspected of modulating estrogenic pathways are responsible for adverse health effects in women. The present review covers the recent literature and assesses the risk of endocrine disrupters to the reproductive health of women.
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National Institute for Environmental Studies, Regional Environment Division.
D000818:Animals; D001559:Benzhydryl Compounds; D004054:Diethylstilbestrol / Q000009:adverse effects; D004147:Dioxins / Q000009:adverse effects; D004703:Endocrine System / Q000187:drug effects; D004785:Environmental Pollutants / Q000009:adverse effects; D004965:Estrogen Antagonists; D004967:Estrogens / Q000502:physiology; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects; D005260:Female; D005831:Genital Diseases, Female / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010636:Phenols / Q000009:adverse effects; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*; D013629:Tamoxifen; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004054:Diethylstilbestrol; D004147:Dioxins; D004785:Environmental Pollutants; D004965:Estrogen Antagonists; D004967:Estrogens; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D013629:Tamoxifen; C006780:bisphenol A; D000098826:Bisphenol A Compounds