Biological properties of citrus flavonoids pertaining to cancer and inflammation.
Citrus flavonoids encompass a diverse set of structures, including numerous flavanone and flavone O- and C-glycosides and methoxylated flavones. Each of these groups of compounds exhibits a number of in vitro and in vivo anti-inflammatory and anticancer actions. These biological properties are consistent with their effects on the microvascular endothelial tissue. Evidence suggests that the biological actions of the citrus flavonoids are possibly linked to their interactions with key regulatory enzymes involved in cell activation and receptor binding. The citrus flavonoids show little effect on normal, healthy cells, and thus typically exhibit remarkably low toxicity in animals. The citrus flavonoids extend their influence in vivo through their induction of hepatic phase I and II enzymes, and through the biological actions of their metabolites. Evidence clearly indicates to the potential health promoting properties of these dietary compounds.
Manthey
J A
JA
US Citrus and Subtropical Products Laboratory, USDA, ARS, SAA, 600 Avenue S, NW, Winter Haven, FL 33881, USA. jmanthey@citrus.usda.gov
Grohmann
K
K
Guthrie
N
N
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002957:Citrus / Q000737:chemistry* / Q000378:metabolism; D005419:Flavonoids / Q000096:biosynthesis / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids