title: Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.
abstract: Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.
authors.affiliation: Department of Rheumatology, University of Göteborg, Göteborg, Sweden. guo-min@immuno.gu.se
authors.forename: G M
authors.initials: GM
authors.lastname: Deng
authors.forename: A
authors.initials: A
authors.lastname: Tarkowski
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D002474:Cell-Free System / Q000276:immunology; D002478:Cells, Cultured; D018899:CpG Islands / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology / Q000378:metabolism; D004269:DNA, Bacterial / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D018664:Interleukin-12 / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009838:Oligodeoxyribonucleotides / Q000008:administration & dosage / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000276:Adjuvants, Immunologic; C408982:CPG-oligonucleotide; D016207:Cytokines; D004269:DNA, Bacterial; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12