title: Effect of Semax on homeostasis of gastric mucosa in albino rats.
abstract: The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University.
authors.forename: S E
authors.initials: SE
authors.lastname: Zhuikova
authors.forename: E A
authors.initials: EA
authors.lastname: Smirnova
authors.forename: Z V
authors.initials: ZV
authors.lastname: Bakaeva
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
authors.forename: I P
authors.initials: IP
authors.lastname: Ashmarin
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects* / Q000503:physiopathology; D006706:Homeostasis / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D018696:Neuroprotective Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone