title: Magnetization transfer MRI: application to treatment of middle cerebral artery occlusion in rat.
abstract: The temporal profiles of MRI parameters which use quantitative estimates of magnetization transfer were measured in 22 male Wistar rats subjected to middle cerebral artery occlusion, with and without therapeutic intervention with an anti-ICAM-1 monoclonal antibody. Two measures were used: the value of a magnetization transfer-related parameter in a predetermined region of interest, and the area of damage, as measured by changes in this parameter. In both groups, the value and area of damage of the inverse of the apparent forward transfer rate for magnetization transfer (1/k(fa)) significantly increased from the preischemic values (P < 0.05), as did T1 under an off-resonance partial saturation of the macromolecular pool (T1sat), and T1 (P < 0.05). Moreover, the increase in the value and total area of damage, as measured by 1/k(fa), T1, and T1sat in the treated group, was smaller compared to that of the untreated group, with significant differences detected between groups at 5, 24, and 48 hours. Our data suggest that a quantitative measure of MT may provide a sensitive and early method to detect the efficacy of therapeutic intervention in experimental stroke.
authors.affiliation: Department of Neurology, Henry Ford Health Sciences Center, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Jiang
authors.forename: J R
authors.initials: JR
authors.lastname: Ewing
authors.forename: Z G
authors.initials: ZG
authors.lastname: Zhang
authors.forename: R L
authors.initials: RL
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Hu
authors.forename: G W
authors.initials: GW
authors.lastname: Divine
authors.forename: P
authors.initials: P
authors.lastname: Arniego
authors.forename: Q J
authors.initials: QJ
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Chopp
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000473:pathology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis* / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000175:diagnosis / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D018799:Intercellular Adhesion Molecule-1