Enantioselective hydride abstraction in organic substrates: a novel use for chiral carbenium ions.
[reaction: see text] It is surprising that chiral cations have not been used to distinguish between prochiral hydrides when converse notions, such as asymmetric addition of a hyride to a prochiral functional group or use of a chiral anion to distinguish between a pair of prochiral protons, are methods employed everyday in enantioselective synthesis. To the best of our knowledge, this Letter describes the first example of an oxidative enantioselective hydride transfer process.
Magdziak
D
D
Department of Chemistry and Biochemistry, University of California at Santa Barbara, 93106, USA.
Pettus
L H
LH
Pettus
T R
TR