title: Microsphaeropsis olivacea keratitis and consecutive endophthalmitis.
abstract: OBJECTIVE
  To report a case of fungal keratitis with consecutive endophthalmitis caused by Microsphaeropsis olivacea.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 51-year-old man developed fungal keratitis and consecutive endophthalmitis after sustaining a penetrating injury to the right eye. Cultures of the aqueous humor yielded M. olivacea. Infection resolved after intraocular fungal debridement, intravitreous amphotericin B, and aggressive topical natamycin and oral fluconazole. Persistent, low-grade smoldering corneal and intraocular inflammation required topical corticosteroid therapy.
  
  
  CONCLUSIONS
  M. olivacea is an exceedingly rare ocular pathogen. The intraocular portion of the infection responded quickly to intravitreal antifungal treatment; however, the course was prolonged by smoldering corneal inflammation. Prompt recognition of intraocular spread and aggressive treatment may be beneficial in fungal infections caused by unusual organisms with uncertain virulence.
authors.affiliation: Baylor College of Medicine, Cullen Eye Institute, Houston, Texas, USA.
authors.forename: C V
authors.initials: CV
authors.lastname: Shah
authors.forename: D B
authors.initials: DB
authors.lastname: Jones
authors.forename: E R
authors.initials: ER
authors.lastname: Holz
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001082:Aqueous Humor / Q000382:microbiology; D065306:Corneal Injuries; D003646:Debridement; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015807:Eye Injuries, Penetrating / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D007908:Lens, Crystalline / Q000293:injuries; D008297:Male; D008875:Middle Aged; D003904:Mitosporic Fungi / Q000302:isolation & purification*; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; C009935:prednisolone acetate; D011239:Prednisolone