title: Histomorphometric analysis of age changes in the human inferior alveolar artery.
abstract: Angiography is often used to investigate age-related changes in the inferior alveolar artery, the major nutrient artery of the mandible. Although histological examinations have been made from several viewpoints, e.g. age change, pathogenesis of osteoradionecrosis, and relation to tooth extraction, these studies have used a limited number of samples and simple histometric methods. The purpose here was to describe histopathological and histomorphometric age-related changes, and to investigate the relation between dentate status and the histomorphometry of the artery. Inferior alveolar arteries from 162 autopsy cases (age range 3-86 years) were examined histometrically with a mathematically standardized method. Histologically, there was diffuse fibrous intimal thickening, but no atheroma formation. Histometric analyses revealed a very gradual increase in both the radius of the artery and the thickness of the media with age, but the luminal radius did not correlate with age. Intimal thickness increased exponentially with age with very different features from those of the increase in the media. The relative radius of the lumen decreased with age after the sixth decade; this is thought to be an index for senile changes in the artery. Among the variables of arterial architecture examined, no particular difference was found between the dentate and non-dentate cases in the molar region.
authors.affiliation: Department of Oral Pathology, Kagoshima University Dental School, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan. semba@dentb.hal.kagoshima-u.ac.jp
authors.forename: I
authors.initials: I
authors.lastname: Semba
authors.forename: K
authors.initials: K
authors.lastname: Funakoshi
authors.forename: M
authors.initials: M
authors.lastname: Kitano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000539:Alveolar Process / Q000098:blood supply*; D001158:Arteries / Q000033:anatomy & histology* / Q000502:physiology; D001161:Arteriosclerosis / Q000473:pathology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000098:blood supply*; D008875:Middle Aged; D012044:Regression Analysis; D017539:Tunica Intima / Q000033:anatomy & histology; D014654:Vascular Patency / Q000502:physiology