Ca2+ signalling during fertilization of echinoderm eggs.
The Ca2+ rise at fertilization of echinoderm eggs is initiated by a process requiring the sequential activation of a Src family kinase, phospholipase C gamma, and the inositol trisphosphate receptor/channel in the endoplasmic reticulum. The consequences of the Ca2+ rise include exocytosis of cortical granules, which establishes a block to polyspermy, and inactivation of MAP kinase, which functions in linking the Ca2+ rise to the reinitiation of the cell cycle.
Jaffe
L A
LA
Department of Physiology, University of Connecticut Health Center, Farmington, CT 06032, USA.ljaffe@neuron.uchc.edu
Giusti
A F
AF
Carroll
D J
DJ
Foltz
K R
KR
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D004447:Echinodermata / Q000502:physiology*; D005306:Fertilization / Q000502:physiology*; D010063:Ovum / Q000166:cytology / Q000502:physiology*