Effect of uridine derivatives on myocardial stunning during postischemic reperfusion of rat heart.
Uridine and uridine-5'-monophosphate prevent myocardial stunning during postischemic reperfusion of isolated rat heart. Uridine-5'-diphosphate does not prevent postischemic myocardial dysfunction, while uridine-5'-triphosphate aggravates it.
Sapronov
N S
NS
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg. sns@iem.spb.ru
Eliseev
V V
VV
Rodionova
O M
OM
D000818:Animals; D021461:Animals, Outbred Strains; D003326:Coronary Circulation / Q000187:drug effects; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000150:complications*; D015425:Myocardial Reperfusion; D017682:Myocardial Stunning / Q000188:drug therapy* / Q000209:etiology; D051381:Rats; D014529:Uridine / Q000494:pharmacology*; D014530:Uridine Diphosphate / Q000494:pharmacology; D014542:Uridine Monophosphate / Q000494:pharmacology; D014544:Uridine Triphosphate / Q000494:pharmacology
D014530:Uridine Diphosphate; D014542:Uridine Monophosphate; D014544:Uridine Triphosphate; D014529:Uridine