title: Therapeutic progress of two sibling cases exhibiting sleep-wake rhythm disorder.
abstract: In this study, two females, siblings who exhibited a non-24 h sleep-wake rhythm (non-24 h) at home were observed. However, they showed a delayed sleep phase syndrome (DSPS) immediately after admission to Kurume University Hospital. Melatonin (3 mg) was commenced following chronotherapy and this improved their sleep-wake rhythm. Polysomnography (PSG) showed decreased sleep latency and increased sleep stage. In these cases, the involvement of environmental factors was strongly suggested for the sleep-wake rhythm abnormalities as well as familial factors.
authors.affiliation: Department of Neuropsychiatry, Kurume University, School of Medicine, Fukuoka, Japan. mukai.m@dream.ocn.ne.jp
authors.forename: M
authors.initials: M
authors.lastname: Mukai
authors.forename: N
authors.initials: N
authors.lastname: Uchimura
authors.forename: N
authors.initials: N
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Waseda
authors.forename: J
authors.initials: J
authors.lastname: Takaishi
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Maeda
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D008550:Melatonin / Q000008:administration & dosage*; D017286:Polysomnography; D012892:Sleep Deprivation; D020178:Sleep Disorders, Circadian Rhythm / Q000235:genetics* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D008550:Melatonin