title: Dogger Bank Itch revisited: isolation of (2-hydroxyethyl) dimethylsulfoxonium chloride as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis.
abstract: (2-Hydroxyethyl) dimethylsulfoxonium chloride (1), the well-known causative agent of Dogger Bank Itch, has been isolated as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis. The structure of 1 was determined by spectral and X-ray crystallographic analyses.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, 113-8657, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Warabi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakao
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.forename: T
authors.initials: T
authors.lastname: Fukuyama
authors.forename: T
authors.initials: T
authors.lastname: Kan
authors.forename: S
authors.initials: S
authors.lastname: Yokoshima
authors.forename: N
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000818:Animals; D002712:Chlorides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000737:chemistry; D003877:Dermatitis, Contact / Q000209:etiology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008956:Models, Chemical; D008958:Models, Molecular; D011161:Porifera / Q000737:chemistry*; D013452:Sulfonium Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D002712:Chlorides; D003603:Cytotoxins; D013452:Sulfonium Compounds; C033899:2-hydroxyethyl-dimethylsulfoxonium