title: The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression.
abstract: The activity of transport system A for neutral amino acids is adaptively stimulated upon amino acid starvation. In cultured human fibroblasts this treatment causes an increase in the expression of the ATA2 system A transporter gene. ATA2 mRNA increase and transport stimulation are suppressed by system A substrates, but they are unaffected by other amino acids. Supplementation of amino acid-starved cells with substrates of system A causes a decrease in both ATA2 mRNA and system A transport activity. These results suggest a direct relationship between ATA2 expression and system A transport activity.
authors.affiliation: Department of Experimental Medicine, University of Parma, Via Volturno 39, 43100 Parma, Italy.
authors.forename: R F
authors.initials: RF
authors.lastname: Gazzola
authors.forename: R
authors.initials: R
authors.lastname: Sala
authors.forename: O
authors.initials: O
authors.lastname: Bussolati
authors.forename: R
authors.initials: R
authors.lastname: Visigalli
authors.forename: V
authors.initials: V
authors.lastname: Dall'Asta
authors.forename: V
authors.initials: V
authors.lastname: Ganapathy
authors.forename: G C
authors.initials: GC
authors.lastname: Gazzola
mesh_terms: D026905:Amino Acid Transport Systems; D015152:Blotting, Northern; D002352:Carrier Proteins / Q000096:biosynthesis*; D002460:Cell Line; D003470:Culture Media / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D011392:Proline / Q000378:metabolism; D021381:Protein Transport; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors
chemical_list: D026905:Amino Acid Transport Systems; D002352:Carrier Proteins; D003470:Culture Media; D012333:RNA, Messenger; D011392:Proline