title: Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress.
abstract: Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate.
authors.affiliation: Brain Research Institute, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. nadja@ ncyt.brain.msk.ru
authors.forename: N A
authors.initials: NA
authors.lastname: Andreeva
authors.forename: E V
authors.initials: EV
authors.lastname: Stel'mashuk
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaya
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: I V
authors.initials: IV
authors.lastname: Viktorov
mesh_terms: D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology*; D005947:Glucose / Q000172:deficiency; D018698:Glutamic Acid / Q000378:metabolism / Q000633:toxicity*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018697:Nootropic Agents / Q000494:pharmacology*; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004151:Dipeptides; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D018698:Glutamic Acid; C103871:ethyl phenylacetyl-Pro-Gly; D015763:2-Amino-5-phosphonovalerate; D005947:Glucose; D010100:Oxygen; D010889:Piracetam