title: Work and productivity loss in the rizatriptan multiple attack study.
abstract: The objective of this study was to measure the self-reported effect of acute migraine and its treatment on paid work and productivity loss. Patients self-administered a questionnaire in which the impact of a recent migraine on paid work and productivity activities was assessed. We included the questionnaire in a randomized, double-blind, placebo-controlled, crossover, out-patient study designed to examine the safety and efficacy of rizatriptan (5-HT1B/1D receptor agonist) 10 mg p.o. in patients treating four separate migraine attacks. A total of 407 patients, aged 18-65 years, suffering from moderate to severe migrainous headaches was studied. Patients receiving rizatriptan compared with placebo reported 0.7 fewer hours (P < 0.01) of paid worked missed due to absenteeism, 0.4 fewer hours (P < 0.05) of productive time lost on the job, and 1.1 fewer total hours (P < 0.01) of work loss per migraine attack. Rizatriptan compared with placebo significantly reduced migraine-related work loss associated with absenteeism and decreased effectiveness on the job.
authors.affiliation: Merck & Co, Inc, Blue Bell, PA 19422, USA. erik_dasbach@merck.com
authors.forename: E J
authors.initials: EJ
authors.lastname: Dasbach
authors.forename: G W
authors.initials: GW
authors.lastname: Carides
authors.forename: W C
authors.initials: WC
authors.lastname: Gerth
authors.forename: N C
authors.initials: NC
authors.lastname: Santanello
authors.forename: J G
authors.initials: JG
authors.lastname: Pigeon
authors.lastname: Kramer
mesh_terms: D000041:Absenteeism; D000328:Adult; D004526:Efficiency / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy* / Q000503:physiopathology*; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D014230:Triazoles / Q000627:therapeutic use*; D014363:Tryptamines; D014937:Work
chemical_list: D017366:Serotonin Receptor Agonists; D014230:Triazoles; D014363:Tryptamines; C093622:rizatriptan