Antitubercular activity of triterpenoids from Lippia turbinata.
Assay-guided fractionation of the antitubercular MeOH-CH(2)Cl(2) extract obtained from Lippia turbinata led to the isolation of four novel triterpenoids-3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-(3-methylbut-2-en-1-oyloxy)olean-12-ene-28-oic acid (1); 3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-angeloyloxyolean-12-ene-28-oic acid (2); 3beta,25-epoxy-3alpha,21alpha-dihydroxy-22beta-tigloyloxyolean-12-ene-28-oic acid (3); and 3beta,25-epoxy-3alpha-hydroxy-22beta-(2-methylbutan-1-oyloxy)olean-12-ene-28-oic acid (4)-together with the known triterpenoids lantanilic acid (5), camaric acid (6), lantanolic acid (7), and rehmannic acid (8). The MIC values of 1-8 for growth inhibition of Mycobacterium tuberculosis were determined in the radiorespirometric BACTEC system.
Wächter
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GA
Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, 1703 E. Mabel Street, Tucson, Arizona 85721-0207, USA.
Valcic
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Franzblau
S G
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Suarez
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Timmermann
B N
BN
D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002677:Chile; D002522:Chlorocebus aethiops; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D010947:Plants, Toxic / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D014709:Vero Cells
D000995:Antitubercular Agents; D010936:Plant Extracts; D014315:Triterpenes