[Treatment of asthma with antileukotrienes and Churg-Strauss syndrome].
Since antileukotriene treatment for asthma was introduced, there has been debate about whether such therapy can lead to Churg-Strauss Syndrome (CSS) or whether CSS is simply inhibited by the use of steroids, as various authors have suggested. We report a case in which we suspected CSS in a patient with bronchopulmonary, cutaneous and analytical signs and whom we treated with oral steroids. After clinical improvement, one year later, steroids were replaced by antileukotrienes, after which the same clinical picture developed. The vasculitis characteristic of CSS was confirmed pathologically.
Sala Félix
J
J
Servicio de Neumología II, Hospital Central de Asturias, Oviedo, Hospital Puerta de Hierro, Madrid.
Pereiro Alonso
M E
ME
Salas Antón
C
C
D000085:Acetates / Q000009:adverse effects*; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D015267:Churg-Strauss Syndrome / Q000139:chemically induced*; D003521:Cyclopropanes; D006801:Humans; D020024:Leukotriene Antagonists / Q000009:adverse effects*; D008297:Male; D011804:Quinolines / Q000009:adverse effects*; D013440:Sulfides
D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast