Antioxidant benzoylated flavan-3-ol glycoside from Celastrus orbiculatus.
A new flavan-3-ol glycoside, (-)-epicatechin-5-O-beta-D-glucosyl-3-benzoate (1), and two known compounds, (-)-epicatechin and (-)-epiafzelechin, were isolated from an EtOAc extract of Celastrus orbiculatus aerial parts that exhibited significant antioxidant effect in a 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical assay. The structure of 1 was elucidated by spectroscopic analyses, and compound 1 and its aglycon, (-)-epicatechin-3-benzoate (2), were found to be moderately active as antioxidants in the DPPH assay.
Hwang
B Y
BY
Anticancer Agent Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
Kim
H S
HS
Lee
J H
JH
Hong
Y S
YS
Ro
J S
JS
Lee
K S
KS
Lee
J J
JJ
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D015764:Bepridil / Q000031:analogs & derivatives* / Q000737:chemistry; D001713:Biphenyl Compounds; D002392:Catechin / Q000737:chemistry / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification*; D005609:Free Radicals / Q000737:chemistry; D006868:Hydrolysis; D010851:Picrates; D010946:Plants, Medicinal / Q000737:chemistry*
D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D010851:Picrates; C120647:epiafzelechin; D015764:Bepridil; D002392:Catechin; C004931:1,1-diphenyl-2-picrylhydrazyl