title: Brainstem function in rapid eye movement sleep behavior disorder: the evaluation of brainstem function by proton MR spectroscopy (1H-MRS).
abstract: Brainstem function was evaluated by proton magnetic resonance (MR) spectroscopy (1H-MRS) in a 69-year-old man with idiopathic rapid eye movement (REM) sleep behavior disorder. An analysis of spectral peak area ratios revealed an increase in the choline/creatine ratio. This change suggests that brainstem neurons have functional impairment at the cell membrane level. Further, our results suggest that 1H-MRS may provide for non-invasive, metabolic evaluation of brainstem neuronal function in REM sleep behavior disorder and find application in the differentiation of secondary REM sleep behavior disorders with neurodegenerative disorders from idiopathic disorders.
authors.affiliation: Department of Neurology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan. miyamasa@dokkyomed.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Miyamoto
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: J
authors.initials: J
authors.lastname: Kubo
authors.forename: N
authors.initials: N
authors.lastname: Yokota
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001933:Brain Stem / Q000503:physiopathology*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004325:Dreams / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011149:Pons / Q000503:physiopathology; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline