title: Pretreatment apoptotic scores do not predict response to radiation therapy in oropharyngeal squamous cell carcinoma.
abstract: The prognostic value of tumor apoptosis was studied in patients with oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Forty-eight patients with oropharyngeal squamous cell carcinoma who received radical radiotherapy between 1990 and 1995 were enrolled in the study. The radiation treatment for all patients involved the administration of 65 Gy in 26 fractions over a 6.5-week period. The apoptotic index (AI; the apoptotic cell count per 1000 tumor cells ) was distributed from 0 to 10 with a median at 2 and a mode of 1. There was a significant linear correlation between the AI and mitotic index (MI) (r=0.393, 95% confidence interval: 0.129-0.605). The cause-specific 5-year survival for patients with AI greater than the median was 46% and for the counterpart was 41%. There was no difference in cause-specific survival between AI/MI greater than the median (50%) and AI/MI smaller than the median (36%). The number of patients was too small to draw definite conclusions, but the AI and the AI/MI before treatment were not shown to have a prognostic value for oropharyngeal squamous cell carcinoma in our study. The primary sites and treatment methods may influence the prognostic value of AI even for the same histological types.
authors.affiliation: Department of Radiology, School of Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo 060-8638, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: H
authors.initials: H
authors.lastname: Shirato
authors.forename: T
authors.initials: T
authors.lastname: Nishioka
authors.forename: A
authors.initials: A
authors.lastname: Yamazaki
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: K
authors.initials: K
authors.lastname: Kagei
authors.forename: K
authors.initials: K
authors.lastname: Oomori
authors.forename: M
authors.initials: M
authors.lastname: Yasuda
authors.forename: M
authors.initials: M
authors.lastname: Shindo
authors.forename: K
authors.initials: K
authors.lastname: Miyasaka
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008940:Mitotic Index / Q000379:methods; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011237:Predictive Value of Tests; D011379:Prognosis