title: Translational roots for mental retardation?
abstract: A flurry of findings points to protein translation in the dendrites of neurons as a key feature leading to the changes at synapses that are vital to learning (see main text). And one recent discovery suggests that when this translation goes awry, it can lead to mental retardation.
authors.forename: M
authors.initials: M
authors.lastname: Barinaga
mesh_terms: D000818:Animals; D003712:Dendrites / Q000378:metabolism*; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D014176:Protein Biosynthesis; D016601:RNA-Binding Proteins; D013569:Synapses / Q000502:physiology*
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human; C497684:Fmr1 protein, mouse