Cell cycle. License withheld--geminin blocks DNA replication.
A cell ensures that its genome is replicated only once during its division cycle through a process called licensing. In an enlightening Perspective, Lygerou and Nurse explain how binding of the Geminin protein to Cdt1 blocks the binding of licensing factors to chromatin, inhibiting the onset of S phase (Wohlschlegel et al.).
Lygerou
Z
Z
Laboratory of General Biology, School of Medicine, University of Patras, 26110 Rio, Patras, Greece. z_lygerou@yahoo.com
Nurse
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P
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D004249:DNA Damage; D004265:DNA Helicases / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D019143:Evolution, Molecular; D064248:Geminin; D006801:Humans; D007399:Interphase; D008677:Metaphase; D008938:Mitosis; D008954:Models, Biological; D051738:Origin Recognition Complex; D016196:S Phase; D014981:Xenopus; D029867:Xenopus Proteins
C467199:CDT1 protein, human; D018797:Cell Cycle Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; C577998:GMNN protein, Xenopus; C577995:GMNN protein, human; D064248:Geminin; D051738:Origin Recognition Complex; D029867:Xenopus Proteins; D004265:DNA Helicases