title: Decreased reuptake of serotonin in human platelets after surgery.
abstract: We have documented earlier a decrease in platelet serotonin and a concurrent increase in plasma serotonin, 5-hydroxytryptamin (5-HT) after various forms of stress, suggesting a disturbed platelet 5-HT reuptake mechanism following stress. In order to further elucidate these findings, we have studied platelet 5-HT reuptake kinetics (Vmax and Km) in nine patients before and 4 days after major, uncomplicated abdominal surgery. We found a significant decrease in the maximal 5-HT reuptake velocity (Vmax) after surgery and changes in Km, verifying alterations in the affinity of the platelet 5-HT transport system. The present results thus confirm the hypothesis that 5-HT reuptake kinetics are altered following adrenergic hyperactivity. A decrease in platelet 5-HT reuptake may bear implications for our understanding of poststress adaptive changes in the cardiovascular system as well as in the central nervous system (CNS) serotonergic neurones following stressful stimulation.
authors.affiliation: Department of Anaesthesiology, Herlev Hospital, and Department of Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark.
authors.forename: O
authors.initials: O
authors.lastname: Naesh
authors.forename: I
authors.initials: I
authors.lastname: Hindberg
authors.forename: A B
authors.initials: AB
authors.lastname: Bruun
mesh_terms: D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000378:metabolism; D011184:Postoperative Period; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin