Uremic toxins and peritoneal dialysis.
Uremic toxicity is related in part to the accumulation of toxic substances, the nature of which has only partly been characterized. Because of the use of a highly permeable membrane and better preservation of the residual renal function, it could be anticipated that some of these uremic toxins are more efficiently cleared across the peritoneal membrane, and that the plasma and tissue levels of these compounds are lower than in hemodialysis patients. This article analyzes the generation and removal of several uremic toxins in peritoneal dialysis patients. The following uremic toxins are discussed: beta2-microglobulin, advanced glycation end products, advanced oxidation protein products, granulocyte inhibitory proteins, p-Cresol, and hyperhomocysteinemia. Some recent studies are reviewed suggesting that uremic toxins are involved in the progression of renal failure and are at least partially removed by peritoneal dialysis. We conclude that, although the plasma levels of some of these compounds are lower in peritoneal dialysis versus hemodialysis patients, it does not mean that the peritoneal dialysis patient is "better" protected against the numerous disturbances caused by these toxins.
Lameire
N
N
Renal Division, Department of Medicine, University Hospital, Gent, Belgium.
Vanholder
R
R
De Smet
R
R
D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology; D003408:Cresols / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D020138:Hyperhomocysteinemia / Q000209:etiology / Q000378:metabolism; D010530:Peritoneal Dialysis; D011506:Proteins / Q000378:metabolism; D014118:Toxins, Biological / Q000378:metabolism*; D014511:Uremia / Q000150:complications / Q000378:metabolism* / Q000628:therapy*; D001613:beta 2-Microglobulin / Q000378:metabolism
D003408:Cresols; D016207:Cytokines; D017127:Glycation End Products, Advanced; D011506:Proteins; D014118:Toxins, Biological; D001613:beta 2-Microglobulin; C085114:granulocyte inhibitory protein, human; C032538:4-cresol