A Brownian model of glutamate diffusion in excitatory synapses of hippocampus.
We simulated the diffusion of glutamate, following the release of a single vesicle from a pre-synaptic terminal, in the synaptic cleft by using a Brownian diffusion model based on Langevin equations. The synaptic concentration time course and the time course of quantal excitatory post-synaptic current have been analyzed. The results showed that they depend on the number of receptors located at post-synaptic membrane. Their time course are dependent both on the total number of the post-synaptic receptors and on the eccentricity of the pre-synaptic glutamate vesicle.
Ventriglia
F
F
Istituto di Cibernetica, CNR, Arco Felice (NA), Italy. franco@biocib.cib.na.cnr.it
Di Maio
V
V
D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D008959:Models, Neurological; D013569:Synapses / Q000378:metabolism*
D018698:Glutamic Acid