title: Serotonergic heterotypic sprouting in the unilaterally dopamine-depleted mouse neostriatum.
abstract: The effects of unilateral 6-hydroxydopamine (6-OHDA) treatment on striatal serotonin neurons in 12-day-old mice were studied using immunohistochemistry. The unilateral 6-OHDA lesions were evaluated with tyrosine hydroxylase (TH) immunohistochemistry. The majority of the TH-immunoreactive structures disappeared from the substantia nigra and neostriatum on the 6-OHDA lesioned side. However, the density of serotonin fibers was markedly increased throughout the 6-OHDA-depleted neostriatum 1 year later. These results suggest that serotonergic heterotypic sprouting may be permanent.
authors.affiliation: Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan. Ichiro.Yamazoe@ma2.seikyou.ne.jp
authors.forename: I
authors.initials: I
authors.lastname: Yamazoe
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Matsushita
authors.forename: H
authors.initials: H
authors.lastname: Kawano
authors.forename: T
authors.initials: T
authors.lastname: Sawada
mesh_terms: D000367:Age Factors; D000818:Animals; D004298:Dopamine / Q000172:deficiency*; D007150:Immunohistochemistry; D051379:Mice; D008813:Mice, Inbred ICR; D017072:Neostriatum / Q000166:cytology* / Q000378:metabolism; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism; D016501:Neurites / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology; D016627:Oxidopamine; D012701:Serotonin / Q000032:analysis / Q000502:physiology*; D013565:Sympatholytics; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
chemical_list: D013565:Sympatholytics; D012701:Serotonin; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine