title: Allgrove syndrome in adulthood.
abstract: A 35-year-old man with a past history of achalasia developed progressive spastic tetraparesis, distal limb atrophy, dysarthria, and dysphagia. A clinical diagnosis of amyotrophic lateral sclerosis (ALS) was considered before neurophysiological investigation, which disclosed a polyneuropathy and a prolonged central conduction time. One year later, the patient developed dysautonomic symptoms. Following confirmation of adrenal insufficiency, a diagnosis of Allgrove syndrome was made. This is a rare case, and we emphasize its clinical similarity with ALS.
authors.affiliation: Department of Neurology, EMG Laboratory, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1600, Lisboa, Portugal.
authors.forename: C
authors.initials: C
authors.lastname: Bentes
authors.forename: M
authors.initials: M
authors.lastname: Santos-Bento
authors.forename: J
authors.initials: J
authors.lastname: de Sá
authors.forename: M
authors.initials: M
authors.lastname: de Lurdes Sales Luís
authors.forename: M
authors.initials: M
authors.lastname: de Carvalho
mesh_terms: D000328:Adult; D004574:Electromagnetic Fields; D004576:Electromyography; D004931:Esophageal Achalasia / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology; D005938:Glucocorticoids / Q000172:deficiency*; D006801:Humans; D007766:Lacrimal Apparatus Diseases / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D013577:Syndrome
chemical_list: D005938:Glucocorticoids