title: Intestinal secretory immunoglobulin A (sIgA) response to Aeromonas exoproteins in patients with naturally acquired Aeromonas diarrhea.
abstract: The secretory immunoglobulin A (sIgA) response at the intestinal mucosa is one of the primary defense mechanisms protecting against enteric infections and may therefore be used as an indicator of bacterial enteropathogenicity. In order to understand the role played by Aeromonas strains as gastrointestinal infectious agents, the sIgA response in fecal specimens obtained from patients with naturally acquired Aeromonas diarrhea was examined. Our results demonstrated a specific sIgA response which was directed against the exoproteins produced by Aeromonas strains. The specific Aeromonas sIgA reacted with extracellular products showing molecular masses similar to those of the Aeromonas hemolytic toxins such as aerolysin and AHH1. Some reactions were directed against other proteins that are known to be important factors in the pathogenicity of Aeromonas. The specific responses highlighted are in support of the view that one should consider at least certain biotypes of Aeromonas enteropathogenic.
authors.affiliation: Istituto Cantonale Batteriosierologico, Laboratory of Microbial Ecology, University of Geneva, Via Ospedale 6, 6904, Lugano, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Crivelli
authors.forename: A
authors.initials: A
authors.lastname: Demarta
authors.forename: R
authors.initials: R
authors.lastname: Peduzzi
mesh_terms: D000328:Adult; D000333:Aeromonas / Q000276:immunology*; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000378:metabolism; D015153:Blotting, Western; D002675:Child, Preschool; D003967:Diarrhea / Q000276:immunology* / Q000382:microbiology; D004591:Electrophoresis, Polyacrylamide Gel; D005243:Feces / Q000382:microbiology; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007223:Infant; D037102:Lectins; D008297:Male; D008875:Middle Aged; D037121:Plant Lectins
chemical_list: D001426:Bacterial Proteins; D007071:Immunoglobulin A, Secretory; D037102:Lectins; D037121:Plant Lectins; C043696:jacalin