Serum albumin as indicator of clinical evolution in patients on parenteral nutrition. Multivariate study.
OBJECTIVE
The aim of this study is to establish whether serum albumin concentration at the beginning of parenteral nutrition is related to morbidity and mortality.


METHODS
In this cohort study spanning four years, a number of patients were classified into twelve groups, depending on their clinical status at the beginning of parenteral nutrition. Their serum albumin concentration and other clinical parameters were then measured and twelve multiple logistic regression models were thus generated in order to model the relationship between initial albumin concentration and risk of morbidity/mortality.


RESULTS
1953 (84%) of the 2321 patients studied were hypoalbuminemic. In six models, this condition was associated with a significant increase in the risk of nosocomial infection. However, no model could be associated to significant risk of renal failure, and only patients with previous hepatopathy were at risk for hepatic failure. In seven models, there was a significant increase in mortality.


CONCLUSIONS
Serum albumin concentration at the beginning of parenteral nutrition is related to mortality and morbidity associated with nosocomial infection in some groups of the study.
Llop
J M
JM
Servicio de Medicina Preventiva, Unidad de Nutrición Parenteral del Servicio de Farmacia, Ciutat Sanitària i Universitària de Bellvitge, Feixa Llarga s/n, E-08907 L'Hospitalet de Llobregat, Spain.
Muñoz
C
C
Badía
M B
MB
Virgili
N
N
Tubau
M
M
Ramón
J M
JM
Pita
A
A
Jódar
J R
JR
D015415:Biomarkers; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000453:epidemiology; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D009017:Morbidity; D009026:Mortality; D015999:Multivariate Analysis; D010288:Parenteral Nutrition; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000453:epidemiology; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis* / Q000378:metabolism
D015415:Biomarkers; D012709:Serum Albumin