In vitro removal of human IgG autoantibodies by affinity filtration using immobilized L-histidine onto PEVA hollow fiber membranes.
Histidine was immobilized onto PEVA membrane to obtain an affinity support for human IgG removal from serum with a view to clinical apheresis for the treatment of autoimmune diseases. These membranes were able to remove in vitro several autoantibodies from the serum of SLE patients.
Ventura
R C
RC
School of Chemical Engineering, State University of Campinas, UNICAMP, SP, Campinas, Brazil.
Zollner
R L
RL
Legallais
C
C
Vijayalakshmi
M
M
Bueno
S M
SM
D000596:Amino Acids / Q000737:chemistry; D000906:Antibodies / Q000302:isolation & purification; D005374:Filtration / Q000379:methods*; D006639:Histidine / Q000737:chemistry*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology / Q000628:therapy; D011145:Polyvinyls / Q000737:chemistry*
D000596:Amino Acids; D000906:Antibodies; D007074:Immunoglobulin G; D011145:Polyvinyls; C020320:ethylene-vinyl alcohol copolymer; D006639:Histidine