title: Thermophilic multidrug-resistant Campylobacter fetus infection with hypersplenism and histiocytic phagocytosis in a patient with acquired immunodeficiency syndrome.
abstract: We present a case report of a patient who had acquired immunodeficiency syndrome (AIDS) and Campylobacter fetus infection with a number of unusual clinical and microbiological features. The patient had prominent gastrointestinal symptoms, splenic infarction, splenomegaly with hypersplenism, and hemophagocytic histiocytosis in the spleen and lymph nodes; the organism displayed growth on Campy-selective blood agar, thermotolerance, and resistance to quinolones, piperacillin/tazobactam, ceftazidime, and erythromycin.
authors.affiliation: Department of Internal Medicine, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. anstead@uthscsa.edu
authors.forename: G
authors.initials: G
authors.lastname: Anstead
authors.forename: J
authors.initials: J
authors.lastname: Jorgensen
authors.forename: F
authors.initials: F
authors.lastname: Craig
authors.forename: M
authors.initials: M
authors.lastname: Blaser
authors.forename: T
authors.initials: T
authors.lastname: Patterson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002169:Campylobacter Infections / Q000150:complications* / Q000382:microbiology; D002168:Campylobacter fetus / Q000187:drug effects*; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D003967:Diarrhea / Q000209:etiology; D004352:Drug Resistance, Microbial; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D006644:Histiocytes / Q000276:immunology*; D015614:Histiocytosis / Q000150:complications; D006801:Humans; D006971:Hypersplenism / Q000150:complications*; D008297:Male; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010587:Phagocytosis; D010878:Piperacillin / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology; D013159:Splenic Infarction / Q000209:etiology; D013163:Splenomegaly / Q000150:complications; D000078142:Tazobactam
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004791:Enzyme Inhibitors; D010406:Penicillins; D015363:Quinolones; D004917:Erythromycin; D010397:Penicillanic Acid; D002442:Ceftazidime; D000078142:Tazobactam; D010878:Piperacillin