[Relation between serum leptin levels, blood parameters and erythropoietin levels in hemodialyzed patients].
BACKGROUND
Serum leptin levels are significantly increased in hemodialysed patients compared to healthy subjects. There are some data suggesting the possible relationship of leptin and the regulation of haematopoiesis. The aim of our study was to compare serum leptin levels in two groups of hemodialysed patients: the group treated by recombinant human erythropoietin (n = 40) (HD + EPO), the group without erythropoietin treatment (HD) and the control group of healthy subjects (n = 20) to explore the influence of erythropoietin treatment on serum leptin levels.


RESULTS
The tendency towards lower body fat content and higher serum leptin levels was found in both groups of HD patients compared to control group, but the differences did not reach statistical significance due to high variability of those parameters (leptinu levels: HD 19.5 +/- 18.5, HD + EPO 24.9 +/- 23.3, K 10.4 +/- 8.8 ng.ml-1). The erythrocyte count and haemoglobin levels in both groups of HD patients were significantly lower than in control group. The erythrocyte count and haemoglobin levels were significantly lower in HD patients treated by erythropoietin compared to untreated HD group. The leptin/body fat content ratio was significantly higher in HD patients compared to healthy subjects (HD 0.86 +/- 0.72, HD + EPO 0.92 +/- 0.78, K 0.35 +/- 0.21, p < 0.05). Serum leptin levels in all studied groups correlated positively with body fat content and negatively with erythrocyte count. No significant relationships of serum leptin levels to erythropoietin levels or other parameters studied were found in any of groups.


CONCLUSIONS
Our study further supported the fact that serum leptin levels in HD patients are relatively higher than in healthy subjects. Serum leptin levels in HD patients treated by recombinant human erythropoietin did not significantly differ from HD patients without this treatment. Except of the negative correlation between serum leptin levels and the erythrocyte count no statistically significant relationships of serum leptin levels and the blood count parameters were found.
Haluzík
M
M
III. interní klinika 1. LF UK a VFN, Praha.
Marková
M
M
Sulková
S
S
Haluzíková
D
D
Svobodová
J
J
Bednárová
V
V
Jiskra
J
J
D001772:Blood Cell Count; D004921:Erythropoietin / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D006435:Renal Dialysis
D006454:Hemoglobins; D020738:Leptin; D011994:Recombinant Proteins; D004921:Erythropoietin