title: Perinatal human hypoxia-ischemia vulnerability correlates with brain calcification.
abstract: Deregulation of intracellular calcium homeostasis is widely considered as one of the underlying pathophysiological mechanisms of hypoxic-ischemic brain injury. Whether this alteration can result in cerebral calcification was investigated in basal ganglia, cerebral cortex, and hippocampus of human premature and term neonates together with glial reaction. In all samples nonarteriosclerotic calcifications were observed, their number and size were area-specific and increased in term neonates. Basal ganglia always presented the highest degree of calcification and hippocampus the lowest, located mainly in the CA1 subfield. In all cases, neuronal damage was associated with astroglial reaction and calcium precipitates, with microglial reaction only in basal ganglia and cerebral cortex, and argues for the participation of excitatory amino acid receptors in hypoxia-ischemia damage. These data correlate with hypoxia-ischemia vulnerability in the perinatal period. The clinical relevance of these precipitates and the neuroprotective interest of non-NMDA receptor manipulation are discussed in the light of our results.
authors.affiliation: Unitat de Bioquímica, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Rodríguez
authors.forename: G
authors.initials: G
authors.lastname: Ursu
authors.forename: F
authors.initials: F
authors.lastname: Bernal
authors.forename: V
authors.initials: V
authors.lastname: Cusí
authors.forename: N
authors.initials: N
authors.lastname: Mahy
mesh_terms: D001479:Basal Ganglia / Q000473:pathology; D002114:Calcinosis / Q000378:metabolism / Q000473:pathology*; D002118:Calcium / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D007231:Infant, Newborn; D009457:Neuroglia / Q000473:pathology
chemical_list: D005904:Glial Fibrillary Acidic Protein; D002118:Calcium