title: Gender-related differences in infrarenal aortic aneurysm morphologic features: issues relevant to Ancure and Talent endografts.
abstract: OBJECTIVE
  The purpose of this study was to determine whether gender-related anatomic variables may reduce applicability of aortic endografting in women.
  
  
  METHODS
  Data on all patients evaluated at our institution for endovascular repair of their abdominal aortic aneurysm were collected prospectively. Ancure (Endovascular Technologies (EVT)/Guidant Corporation, Menlo Park, Calif) and Talent (World Medical/Medtronic Corporation, Sunrise, Fla) endografts were used. Preoperative imaging included contrast-enhanced computed tomography and arteriography or magnetic resonance angiography.
  
  
  RESULTS
  One hundred forty-one patients were evaluated (April 1998-December 1999), 19 women (13.5%) and 122 men (86.5%). Unsuitable anatomy resulted in rejection of 63.2% of the women versus only 33.6% of the men (P = .026). Maximum aneurysm diameter in women and men were similar (women, 56.94 +/- 8.23 mm; men, 59.29 +/- 13.22 mm; P = .5). The incidence of iliac artery tortuosity was similar across gender (women, 36.8%; men, 54.9%; P = .2). The narrowest diameter of the larger external iliac artery in women was significantly smaller (7.29 +/- 2.37 mm) than in men (8.62 +/- 2.07 mm; P = .02). The proximal neck length was significantly shorter in women (10.79 +/- 12.5 mm) than in men (20.47 +/- 19.5 mm; P = .02). The proximal neck width was significantly wider in women (30.5 +/- 2.4 mm) than in men (27.5 +/- 2.5 mm; P = .013). Proximal neck angulation (>60 degrees) was seen in a significantly higher proportion of women (21%) than men (3.3%; P = .012). Of the patients accepted for endografting, a significantly higher proportion of women required an iliofemoral conduit for access (women, 28.6%; men, 1.2%; P = .016).
  
  
  CONCLUSIONS
  Gender-related differences in infrarenal aortic aneurysm morphologic features may preclude widespread applicability of aortic endografting in women, as seen by our experience with the Ancure and Talent devices. In addition to a significantly reduced iliac artery size, women are more likely to have a shorter, more dilated, more angulated proximal aortic neck.
authors.affiliation: Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
authors.forename: O C
authors.initials: OC
authors.lastname: Velazquez
authors.forename: R A
authors.initials: RA
authors.lastname: Larson
authors.forename: R A
authors.initials: RA
authors.lastname: Baum
authors.forename: J P
authors.initials: JP
authors.lastname: Carpenter
authors.forename: M A
authors.initials: MA
authors.lastname: Golden
authors.forename: M E
authors.initials: ME
authors.lastname: Mitchell
authors.forename: A
authors.initials: A
authors.lastname: Pyeron
authors.forename: C F
authors.initials: CF
authors.lastname: Barker
authors.forename: R M
authors.initials: RM
authors.lastname: Fairman
mesh_terms: D000368:Aged; D000792:Angiography; D017130:Angioplasty / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods* / Q000401:mortality / Q000706:statistics & numerical data; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods* / Q000401:mortality / Q000706:statistics & numerical data; D002423:Cause of Death; D015897:Comorbidity; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D018579:Patient Selection; D011446:Prospective Studies; D011474:Prosthesis Design; D012307:Risk Factors; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome