Prognostic value of cytogenetic findings in adults with acute myeloid leukemia.
The majority of adults diagnosed with acute myeloid leukemia (AML) display acquired cytogenetic aberrations at presentation. Numerous recurring chromosomal abnormalities have been and continue to be identified in AML. In many instances, genes altered by these aberrations have been cloned, providing insights into the mechanisms of leukemogenesis and paving the way to designing novel therapeutic strategies that target specific genetic abnormalities in leukemic blasts. Moreover, karyotypic abnormalities, whether molecularly characterized or not, are among the most important independent prognostic factors in AML and are being used in the clinical management of AML patients. In this review, we present an overview of major cytogenetic findings in AML and discuss associations between karyotype and clinical outcome of adults with AML.
Mrózek
K
K
Division of Hematology and Oncology and the Comprehensive Cancer Center, The Authur G. James Cancer Hospital, The Ohio State University, Columbus 43210-1228, USA. mrozek-1@medctr.osu.edu
Heinonen
K
K
Bloomfield
C D
CD
D000208:Acute Disease; D000328:Adult; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis