Modifying with mitochondria.
An elegant set of mouse crosses has been used to identify a mitochondrial variant that interacts with a nuclear locus on chromosome 10, Ahl, to modify age-related hearing loss. This discovery sets the stage for the identification of factors that modify expression levels and variability of human hearing impairments.
Avraham
K B
KB
Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. karena@post.tau.ac.il
D000367:Age Factors; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D003433:Crosses, Genetic; D003638:Deafness / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D008928:Mitochondria / Q000235:genetics*; D009154:Mutation; D019655:Quantitative Trait, Heritable