High-dose intravenous ribavirin therapy for subacute sclerosing panencephalitis.
Two patients with subacute sclerosing panencephalitis (SSPE) were treated safely and effectively with high doses of intravenous ribavirin combined with intraventricular alpha interferon. The ribavirin concentrations maintained in the serum and cerebrospinal fluid were higher than those which inhibit SSPE virus replication in vitro and in vivo.
Hosoya
M
M
Department of Pediatrics, School of Medicine, Fukushima Medical University, Japan. mhosoya@fmu.ac.jp
Shigeta
S
S
Mori
S
S
Tomoda
A
A
Shiraishi
S
S
Miike
T
T
Suzuki
H
H
D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012254:Ribavirin / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D013344:Subacute Sclerosing Panencephalitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D016896:Treatment Outcome; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D012254:Ribavirin