title: Diabetes insipidus revealing acute myelogenous leukaemia with a high platelet count, monosomy 7 and abnormalities of chromosome 3: a new entity?
abstract: We describe three cases of acute myeloid leukaemia revealed by diabetes insipidus. The patients were 42, 38 and 39 yr old and they had marked hyperleukocytosis, circulating immature granular cells and a normal or elevated platelet count. The leukaemia was type AML-M2 according to the FAB classification. Cytogenetic studies showed inversion of chromosome 3 (q21;q26) in 2 cases and a translocation (3;3)(q21;q29?) in the remaining case, both associated with monosomy 7. All the cerebral CT scans were normal. Complete remission was never achieved, and all three patients survived less than 14 months. Desmopressin therapy was active but treatment could not be reduced. The association of dysmegakaryopoiesis with a chromosome 3 abnormality and diabetes insipidus is probably not fortuitous and could represent a new entity.
authors.affiliation: Laboratoire de Biologie cellulaire et de Cytogénétique Moléculaire, Faculté de Médecine de Montpellier-Nîmes, France. t-lavabre@usa.net
authors.forename: T
authors.initials: T
authors.lastname: Lavabre-Bertrand
authors.forename: P
authors.initials: P
authors.lastname: Bourquard
authors.forename: J
authors.initials: J
authors.lastname: Chiesa
authors.forename: M F
authors.initials: MF
authors.lastname: Berthéas
authors.forename: G
authors.initials: G
authors.lastname: Lefort
authors.forename: J
authors.initials: J
authors.lastname: Taïb
authors.forename: C
authors.initials: C
authors.lastname: Lavabre-Bertrand
authors.forename: M
authors.initials: M
authors.lastname: Navarro
authors.forename: J P
authors.initials: JP
authors.lastname: Bureau
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure*; D002897:Chromosomes, Human, Pair 7; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000188:drug therapy / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D007964:Leukocytosis / Q000209:etiology; D008297:Male; D009006:Monosomy; D010976:Platelet Count; D013922:Thrombocytosis / Q000209:etiology*; D014178:Translocation, Genetic
chemical_list: D003894:Deamino Arginine Vasopressin