title: [HBV markers in severe hepatitis B].
abstract: In order to elucidate the relationship between hepatitis B virus (HBV) replication and severity of hepatitis B, HBV serological markers and HBV-DNA in 56 patients with chronic hepatitis B were detected using the methods of ELISA and PCR, respectively. The results showed that the positive prevalence of HBeAg and/or HBV-DNA in chronic severe hepatitis B (5/25) was much lower than that in non-severe chronic hepatitis B (26/31) (P < 0.01). The study provides the suggestive evidence that viral replication is significantly reduced in severe hepatitis B. Also, increased replication of HBV appears to be not the cause of hepatic necrosis in severe hepatitis B.
authors.affiliation: Department of Infectious Diseases, Xiangya Hospital, Hunan Medical University, Changsha 410008.
authors.forename: X
authors.initials: X
authors.lastname: Fan
authors.forename: P
authors.initials: P
authors.lastname: Ren
authors.forename: S
authors.initials: S
authors.lastname: Weng
authors.forename: G
authors.initials: G
authors.lastname: Hu
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000097:blood; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D006513:Hepatitis B e Antigens