title: Collateral projections of nucleus raphe dorsalis neurones to the caudate-putamen and region around the nucleus raphe magnus and nucleus reticularis gigantocellularis pars alpha in the rat.
abstract: It was examined whether or not the nucleus raphe dorsalis (RD) neurons projecting to the caudate-putamen (CPu) might also project to the motor-controlling region around the nucleus raphe magnus (NRM) and nucleus reticularis gigantocellularis pars alpha (Gia) in the rat. Single RD neurons projecting to the CPu and NRM/Gia by way of axon collaterals were identified by the retrograde double-labeling method with fluorescent dyes, Fast Blue and Diamidino Yellow, which were injected respectively into the CPu and NRM/Gia. Then, serotonin (5-HT)-like immunoreactivity of the double-labeled RD neurons was examined immunohistochemically; approximately 60% of the double-labeled RD neurons showed 5-HT-like immunoreactivity. The results indicated that some of serotonergic and non-serotonergic RD neurons might control motor functions simultaneously at the levels of the CPu and NRM/Gia by way of axon collaterals.
authors.affiliation: Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Li
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: N
authors.initials: N
authors.lastname: Mizuno
mesh_terms: D000578:Amidines / Q000494:pharmacology; D000818:Animals; D001369:Axons / Q000378:metabolism / Q000648:ultrastructure*; D002452:Cell Count; D005456:Fluorescent Dyes / Q000494:pharmacology; D007150:Immunohistochemistry; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology* / Q000378:metabolism; D008636:Mesencephalon / Q000166:cytology* / Q000378:metabolism; D017072:Neostriatum / Q000166:cytology* / Q000378:metabolism; D009434:Neural Pathways / Q000166:cytology* / Q000378:metabolism; D011903:Raphe Nuclei / Q000166:cytology* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012154:Reticular Formation / Q000166:cytology* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
chemical_list: D000578:Amidines; D005456:Fluorescent Dyes; C031455:diamidino compound 253-50; D012701:Serotonin; C037945:diamidino yellow