Contrast-enhanced MR imaging of experimental acute tubular necrosis.
OBJECTIVE
To demonstrate the involvement of the various renal structures in acute tubular necrosis (ATN).


METHODS
In 15 rats, using a T1-/T2-weighted sequence, either gadodiamide alone, or gadodiamide in combination with sprodiamide (a susceptibility agent) were used to enhance the various anatomical substrates of the kidney. The results were compared to those of pathological verification.


RESULTS
Experimentally induced ATN of the rat kidney causes profound changes in the medulla, leaving the cortex largely intact. The difference between the normal cortex and the partially necrotic outer medulla, on the one hand, and the papillary region, was significantly enhanced with the combination, whereas a larger region composed of the inner and outer medulla was enhanced after the gadolinium chelate alone.


CONCLUSIONS
The results varied considerably between the two procedures; the double contrast demonstrated a clear difference between the inner and outer medulla, and the gadolinium chelate alone demonstrated a clear difference between the medulla and the cortex. These results demonstrated a clear difference in the compartmentalization between the inner and outer medullary regions, providing complementary information about the pathological condition of the kidney.
Dupas
B
B
Department of Radiology and Medical Imaging, Centre Hospitalier Universitaire, Nantes, France.
Buzelin
M F
MF
Karam
G
G
Vasse
N
N
Meflah
K
K
Bach-Gansmo
T
T
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D004338:Drug Combinations; D004419:Dysprosium; D019786:Gadolinium DTPA / Q000008:administration & dosage; D007275:Injections, Intravenous; D007679:Kidney Medulla / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000175:diagnosis*; D007684:Kidney Tubules / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D051381:Rats; D011914:Rats, Inbred BN
D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; C061756:sprodiamide; D004419:Dysprosium; D004369:Pentetic Acid; C064925:gadodiamide; D019786:Gadolinium DTPA