title: Pro-inflammatory cytokine production by synoviocytes following exposure to protein I/II, a modulin from oral streptococci.
abstract: We have tested the ability of protein I/II, an adhesin from oral streptococci, to stimulate the production of pro-inflammatory cytokines by synovial cells isolated from both rheumatoid arthritis and control patients. Protein I/II triggers synovial fluid cells to produce interleukin (IL)-6 and IL-8 while secretion of tumor necrosis factor-alpha (TNF-alpha) was less enhanced. Using fibroblast-like synoviocytes, we found that protein I/II also exerts an immunomodulatory effect (IL-6 and IL-8 release) on these cells. These findings indicate that, if it gains access to the joint cavity, protein I/II could participate in the initiation and/or perpetuation of rheumatic diseases, by stimulating pro-inflammatory cytokine release from various synovial cells.
authors.affiliation: INSERM U392, Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, Illkirch, France.
authors.forename: B
authors.initials: B
authors.lastname: Gourieux
authors.forename: S
authors.initials: S
authors.lastname: Al-Okla
authors.forename: M
authors.initials: M
authors.lastname: Schöller-Guinard
authors.forename: J
authors.initials: J
authors.lastname: Klein
authors.forename: J
authors.initials: J
authors.lastname: Sibilia
authors.forename: D
authors.initials: D
authors.lastname: Wachsmann
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics / Q000276:immunology*; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000503:physiopathology*; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000276:immunology; D013295:Streptococcus mutans / Q000378:metabolism*; D013582:Synovial Fluid / Q000166:cytology / Q000276:immunology*
chemical_list: D018829:Adhesins, Bacterial; D016207:Cytokines; D011994:Recombinant Proteins