Characterisation of the transition states for protein folding: towards a new level of mechanistic detail in protein engineering analysis.
The field of protein folding now offers considerable excitement. Comparative studies of the transition-state structures for a series of protein families with analogous structures have helped to uncover the overall rules for protein folding. In addition, new protein engineering experiments that continuously follow the growth of the folding nucleus have started to fill in the missing details.
Oliveberg
M
M
Biochemistry, Umeå University, 901 87 Umeå, Sweden. mikael.oliveberg@chem.umu.se
D008956:Models, Chemical; D008958:Models, Molecular; D015202:Protein Engineering; D017510:Protein Folding; D013816:Thermodynamics