title: The value of MnDPDP enhancement during MR guided laser interstitial thermoablation of liver tumors.
abstract: Magnetic resonance (MR)-guided thermal ablation procedures are feasible in modern open low field strength MR scanners. The compromises for rapid imaging in this configuration worsen liver lesino conspicuity. To overcome this, we utilize liver-specific contrast Mangafodipir Trisodium (MnDPDP) to improve lesion recognition and targeting and allow a longer contrast-assisted window. Three observers assessed pre- and post-contrast MR scans of 14 liver ablation patients. They assessed the number of lesions, ease of puncture planning, conspicuity of lesions, gallbladder, vessels, and surrounding bowel. There was a significant improvement in lesion conspicuity and ease of puncture planning when MnDPDP was used. In two of the observers, there was also a significant improvement in the number of lesions seen and in bowel conspicuity. No significant difference was shown in the detection of the gallbladder or vessels. We conclude that the liver-specific contrast agent MnDPDP improves the overall accuracy and safety of MR-guided thermal ablation of liver tumors facilitating this procedure at lower field strengths. J. Magn. Reson. Imaging 2001;13:37-41.
authors.affiliation: Department of Interventional Magnetic Resonance, St. Mary's Hospital, London, United Kingdom.
authors.forename: R
authors.initials: R
authors.lastname: Joarder
authors.forename: M
authors.initials: M
authors.lastname: de Jode
authors.forename: G A
authors.initials: GA
authors.lastname: Lamb
authors.forename: W M
authors.initials: WM
authors.lastname: Gedroyc
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D004492:Edetic Acid / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D017075:Laser Coagulation; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives*
chemical_list: D003287:Contrast Media; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid