title: Evaluation of premalignant potential in oral lichen planus using interphase cytogenetics.
abstract: This study attempted to evaluate whether oral lichen planus (OLP) has the potential to progress to oral squamous cell carcinoma (OSCC) by comparing the degree of genetic instability between clinically-curable OLP and lesions that progressed to OSCC. Fifteen cases of steroid-responsive OLP and two cases of lichenoid dysplasia (LD) that progressed to OSCC were used for this study. Chromosome in situ hybridization (CISH) was performed for chromosomes 9 and 17. The fraction of polysomic and monosomic cells for chromosome 9 increased in mucosal epithelium compared to those of lymphocytes in OLP. This difference was statistically significant (P=0.0017, 0.0054, respectively). Two LD patients showed 15.38% and 22.58% of PI for chromosome 9. In OSCC that developed from LD, the fraction of monosomic cells for chromosome 9 increased by more than 70%. We concluded that LD should be treated as a high-risk premalignant lesion and strongly suggest that the monosomy of chromosome 9 may have a critical role in progress to malignancy from LD.
authors.affiliation: Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry, Seoul, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: J I
authors.initials: JI
authors.lastname: Yook
authors.forename: E H
authors.initials: EH
authors.lastname: Lee
authors.forename: M H
authors.initials: MH
authors.lastname: Ryu
authors.forename: J H
authors.initials: JH
authors.lastname: Yoon
authors.forename: J C
authors.initials: JC
authors.lastname: Hong
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000328:Adult; D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D003582:Cytogenetics; D018450:Disease Progression; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007399:Interphase / Q000235:genetics*; D017676:Lichen Planus, Oral / Q000235:genetics* / Q000473:pathology; D017512:Lichenoid Eruptions / Q000235:genetics / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009006:Monosomy / Q000235:genetics; D009059:Mouth Diseases / Q000235:genetics / Q000473:pathology; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology