Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields.
Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF-MF). We report that ELF-MF, though not perturbing cell cycle progression, increases the rate of cell death in normal cell lines. In contrast, cell death is not affected in cells from genetic instability syndromes; this reflects a specific failure of the apoptotic response. Reintroduction of complementation group C in FA cells re-established the apoptotic response to ELF-MF. Thus, genes implicated in genetic instability syndromes are relevant in modulating the response of cells to ELF-MF.
Mangiacasale
R
R
CNR Centro di Genetica Evoluzionistica c/o Università La Sapienza, Rome, Italy.
Tritarelli
A
A
Sciamanna
I
I
Cannone
M
M
Lavia
P
P
Barberis
M C
MC
Lorenzini
R
R
Cundari
E
E
D017209:Apoptosis; D001260:Ataxia Telangiectasia / Q000235:genetics / Q000473:pathology; D002453:Cell Cycle; D016923:Cell Death; D002460:Cell Line; D005199:Fanconi Anemia / Q000235:genetics / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008280:Magnetics / Q000009:adverse effects*; D008854:Microscopy, Electron; D009154:Mutation; D014162:Transfection