title: Detection of caustic oesophageal injury with technetium 99m-labelled sucralfate.
abstract: OBJECTIVE
  Radiolabelled sucralfate has been used to show the extent and severity of reflux oesophagitis, peptic ulceration, and inflammatory bowel disease. Endoscopy under general anaesthetic has been the preferred method to assess the injury after caustic ingestion. The aim of this study was to assess whether sucralfate has an affinity for the chemically injured oesophageal mucosa and, if so, to assess the accuracy of radiolabeled sucralfate as an indicator of presence and extent of oesophageal injury.
  
  
  METHODS
  A prospective study was conducted of 22 patients with mean age of 30 months (range, 13 to 90) admitted consecutively with a history of caustic ingestion between January 1998 and January 2000. A sucralfate-labelled scan followed by endoscopic assessment of upper gastrointestinal tract with documentation of extent and grade of injury was performed in all patients within 24 hours of admission except the first 6 who underwent scan after the endoscopy. The sucralfate was labelled by the direct stannous reduction method. Oesophageal transit was studied by recording 120 images (64 x 64 matrix size) at 1 image per second while the child swallowed 5 mL of labelled sucralfate containing 2 to 3 MBq Technetium 99m. Retention of radiolabelled oesophageal activity was considered abnormal.
  
  
  RESULTS
  The caustic substances ingested were household cleaners in 18, potassium permanganate in 3, and pool chlorine in 1. There were 11 scans that showed residual activity in the oesophagus, which correlated exactly with endoscopic findings. The other 11 patients had normal oesophageal mucosa, but 2 were found to be falsely positive on scanning. In 2 cases repeat sucralfate scan results correlated well with the healing process assessed endoscopically.
  
  
  CONCLUSIONS
  The results indicate that technetium 99m sucralfate swallow is an accurate technique for assessing oesophageal injury after ingestion of caustic substances. In addition, it may be used to document healing.
authors.affiliation: Department of Paediatric Surgery, University of Cape Town, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
authors.forename: A J
authors.initials: AJ
authors.lastname: Millar
authors.forename: A
authors.initials: A
authors.lastname: Numanoglu
authors.forename: M
authors.initials: M
authors.lastname: Mann
authors.forename: S
authors.initials: S
authors.lastname: Marven
authors.forename: H
authors.initials: H
authors.lastname: Rode
mesh_terms: D002057:Burns, Chemical / Q000000981:diagnostic imaging*; D002424:Caustics / Q000009:adverse effects*; D002675:Child, Preschool; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000000981:diagnostic imaging; D004947:Esophagus / Q000000981:diagnostic imaging / Q000293:injuries*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015609:Organotechnetium Compounds; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013392:Sucralfate; D015599:Trauma Severity Indices
chemical_list: D002424:Caustics; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C038248:technetium Tc 99m sucralfate; D013392:Sucralfate