HLA-B*07 allele frequencies and haplotypic associations in Koreans.
We have investigated the frequencies of HLA-B*07 alleles and their haplotypic associations with HLA-A, -C and -DRB1 loci in 489 healthy unrelated Koreans, including 214 parents from 107 families. All of the 45 samples (9.2%) typed as B7 by serology were analyzed for B*07 alleles using polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) method. Two different B*07 alleles were detected: B*0702 (allele frequency 0.041) and B*0705 (0.005). Two characteristic haplotypes showing strong linkage disequilibrium in Koreans were A*2402-Cw*07-B*0702-DRB1*0101 (haplotype frequency 0.028) and A*2901-B*0705-DRB1*0803 (0.005). The characteristic haplotype A*2901-B*0705-DRB1*0803, found in 100% (5/5) of B*0705-positive individuals, has not been previously described in other ethnic groups. HLA-B7 alleles comprise distinctive extended haplotypes in the Korean population. The probability of HLA-B7 allele mismatches among ABDR-matched unrelated donor-recipient pairs is expected to be low in Koreans.
Whang
D H
DH
Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea.
Kang
S J
SJ
Han
K S
KS
Park
M H
MH
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015793:HLA-B7 Antigen; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007723:Korea
D015235:HLA-B Antigens; C425023:HLA-B*07 antigen; D015793:HLA-B7 Antigen