Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow.
OBJECTIVE
To investigate the role of sonographic parameters in assessing endometrial receptivity in an in vitro fertilization (IVF) program.


METHODS
Prospective clinical study.


METHODS
University setting.


METHODS
One hundred thirty-five patients in our IVF program, selected prospectively on the day of oocyte retrieval.


METHODS
Transvaginal ultrasound examination was performed before oocyte collection.


METHODS
Association between implantation rate and spiral artery blood flow (primary outcome measure) and between implantation rate and endometrial measurements as well as uterine artery blood flow (secondary outcome measures).


RESULTS
Overall implantation rate was 23.7% per cycle. Subendometrial blood flow was detected in 113 (83.7%) cases, with pregnancy occurring in 21.2%. Mean spiral artery pulsatility index values were 1.12 +/- 0.28 and 1.21 +/- 0.27 for nonconception and conception cycles, respectively. Nondetectable spiral artery blood flow was not associated with a lower implantation rate. Neither endometrial thickness nor endometrial volume was correlated with the likelihood of successful implantation. Minimum endometrial thickness and volume associated with pregnancy were 6.9 mm and 1.59 mL, respectively.


CONCLUSIONS
Neither Doppler sonography of the spiral or uterine arteries nor measurement of the endometrial thickness or volume allowed a reliable prediction of subsequent IVF outcome.
Schild
R L
RL
Abteilung für Pränatale Diagnostik und Therapie, Frauenklinik der Universität, Bonn, Germany. r.schild@uni-bonn.de
Knobloch
C
C
Dorn
C
C
Fimmers
R
R
van der Ven
H
H
Hansmann
M
M
D001158:Arteries / Q000502:physiology; D001783:Blood Flow Velocity; D010064:Embryo Implantation; D004624:Embryo Transfer; D004717:Endometrium / Q000000981:diagnostic imaging* / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011446:Prospective Studies; D011673:Pulsatile Flow; D014463:Ultrasonography; D014599:Uterus / Q000098:blood supply*