Failure of mebendazole in the treatment of humans with Trichinella spiralis infection at the stage of encapsulating larvae.
Trichinella spiralis larvae infective for laboratory mice were collected from muscle biopsies performed at different times (from 1 day to 16 months) following the end of treatment, indicating the failure of mebendazole to kill Trichinella parasites when they are encapsulating in muscles.
Pozio
E
E
Laboratory of Parasitology, Istituto Superiore di Sanità, Rome, Italy. pozio@iss.it
Sacchini
D
D
Sacchi
L
L
Tamburrini
A
A
Alberici
F
F
D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D001706:Biopsy; D006801:Humans; D007814:Larva / Q000187:drug effects / Q000502:physiology; D008463:Mebendazole / Q000627:therapeutic use*; D009132:Muscles / Q000469:parasitology; D017211:Treatment Failure; D017160:Trichinella spiralis / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D014235:Trichinellosis / Q000188:drug therapy* / Q000469:parasitology
D000969:Antinematodal Agents; D008463:Mebendazole