Heat shock proteins: the fountainhead of innate and adaptive immune responses.
The ability of heat shock proteins to (1) chaperone peptides, including antigenic peptides; (2) interact with antigen-presenting cells through a receptor; (3) stimulate antigen-presenting cells to secrete inflammatory cytokines; and (4) mediate maturation of dendritic cells, makes them a unique starting point for generation of immune responses. These properties also permit the use of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases.
Basu
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S
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington 06030-1601, USA.
Srivastava
P K
PK
D000222:Adaptation, Physiological / Q000276:immunology*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000276:immunology*
D006360:Heat-Shock Proteins