title: PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases.
abstract: A new protein domain was found in several proteins involved in apoptosis, inflammation, cancer and immune responses. Its location within these proteins and predicted fold suggests that it functions as a protein-protein interaction domain, possibly uniting different signaling pathways.
authors.affiliation: Program in Bioinformatics and Biological Complexity, The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: K
authors.initials: K
authors.lastname: Pawłowski
authors.forename: F
authors.initials: F
authors.lastname: Pio
authors.forename: Z
authors.initials: Z
authors.lastname: Chu
authors.forename: J C
authors.initials: JC
authors.lastname: Reed
authors.forename: A
authors.initials: A
authors.lastname: Godzik
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D016208:Databases, Factual; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism*; D011485:Protein Binding; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D000071198:Pyrin; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D003598:Cytoskeletal Proteins; D011506:Proteins; D000071198:Pyrin