title: Childhood bullous pemphigoid developed after the first vaccination.
abstract: Bullous pemphigoid (BP) typically affects the elderly. There are at least 40 reported cases of BP in childhood, 10 reported cases at 1 year of age or younger. The antigen of this autoimmune disease is localized to the hemidesmosome. Neoplasia, recurrent trauma, some systemic diseases, and psoriasis were previously reported as possible triggering factors of bullous pemphigoid in some cases. In the last 5 years, 10 adult and 2 infantile BP cases with a close relation of vaccination have been reported. Anti-influenza vaccine, tetanus toxoid booster, and tetracoq vaccine were the possible causes of these cases. We report herein a 3.5-month-old BP case in whom the lesions developed 24 hours after the first tetracoq vaccine. We suggest that vaccination may be the triggering factor of BP of any age by stimulating the immune system with an unexplained mechanism.
authors.affiliation: Department of Dermatology, Istanbul Medical Faculty, Istanbul University, Turkey. baykalc@istambul.edu.tr
authors.forename: C
authors.initials: C
authors.lastname: Baykal
authors.forename: G
authors.initials: G
authors.lastname: Okan
authors.forename: R
authors.initials: R
authors.lastname: Sarica
mesh_terms: D000900:Anti-Bacterial Agents; D001707:Biopsy, Needle; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D010391:Pemphigoid, Bullous / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D023321:Poliovirus Vaccines / Q000009:adverse effects*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014611:Vaccination / Q000009:adverse effects
chemical_list: D000900:Anti-Bacterial Agents; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D023321:Poliovirus Vaccines; D008775:Methylprednisolone