Mechanisms of action of intravenous immunoglobulin (IVIG).
Therapeutic preparations of pooled normal polyspecific immunoglobulin G for intravenous use (intravenous immunoglobulin, IVIG) have been shown to be effective in the treatment of a number of autoimmune and systemic inflammatory conditions. IVIG prevents the occurrence of experimental autoimmune encephalomyelitis. Increasing evidence suggests that IVIG is of benefit in patients with relapsing-remitting multiple sclerosis. The present review discusses the immunoregulatory properties and mechanisms of action of IVIG in autoimmune disease.
Kazatchkine
M D
MD
INSERM U430 and Université Pierre et Marie Curie, H pital Broussais, Paris, France.
Bellon
B
B
Kaveri
S V
SV
D000906:Antibodies / Q000187:drug effects; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D001402:B-Lymphocytes / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D011961:Receptors, Fc / Q000502:physiology; D013601:T-Lymphocytes / Q000187:drug effects
D000906:Antibodies; D016756:Immunoglobulins, Intravenous; D011961:Receptors, Fc