title: Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats.
abstract: Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.
authors.affiliation: Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Pravenec
authors.forename: V
authors.initials: V
authors.lastname: Landa
authors.forename: V
authors.initials: V
authors.lastname: Zidek
authors.forename: A
authors.initials: A
authors.lastname: Musilova
authors.forename: V
authors.initials: V
authors.lastname: Kren
authors.forename: L
authors.initials: L
authors.lastname: Kazdova
authors.forename: T J
authors.initials: TJ
authors.lastname: Aitman
authors.forename: A M
authors.initials: AM
authors.lastname: Glazier
authors.forename: A
authors.initials: A
authors.lastname: Ibrahimi
authors.forename: N A
authors.initials: NA
authors.lastname: Abumrad
authors.forename: N
authors.initials: N
authors.lastname: Qi
authors.forename: J M
authors.initials: JM
authors.lastname: Wang
authors.forename: E M
authors.initials: EM
authors.lastname: St  Lezin
authors.forename: T W
authors.initials: TW
authors.lastname: Kurtz
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D018955:CD36 Antigens / Q000096:biosynthesis / Q000235:genetics*; D005227:Fatty Acids / Q000097:blood; D005951:Glucose Tolerance Test; D006973:Hypertension / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics*; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D018955:CD36 Antigens; D005227:Fatty Acids