title: Why are NICU infants at risk for chronic otitis media with effusion?
abstract: Newborns in a Neonatal Intensive Care Unit (NICU) and even later have a high incidence of otitis media with effusion (OME). It is unclear which aspects play a role in the incidence of chronic OME during infancy. In order to investigate the effect of nasally-placed tubes, cranial growth, immune system, and neuromotor function on the occurrence of chronic OME, 83 NICU patients were observed prospectively for middle ear status. Duration and type of treatment with nasal tubes were obtained from the NICU notes. At the NICU, and 1 and 2 years of age the cranial circumference and neuromotor function were assessed. As a proxy for disturbed local immune system parental reports of snoring, mouth breathing and common cold were used. Multivariate analysis revealed that infants treated with nasotracheal and nasopharyngeal tubes showed a marginally significant increased risk for chronic OME (OR=3.2 [95% CI 0.5--21.2]). Treatment with nasogastric tubes appeared to have a lower risk for chronic OME (OR=1.5 [95% CI 0.1--25.1]). No significant effect was found for cranial circumference. Signs of disturbed local immunity during the first 6 months of life (OR=1.4 [95% CI 0.4--4.7]), as well as impaired neuromotor function (OR=1.9 [95% CI 0.5--6.8]), showed also a marginally significant increased risk for chronic OME. The cohort of NICU patients might be relatively too small in order to find significant effects. Although the results of this study should be interpreted cautiously, it is suggested that nasally-placed tubes for ventilatory assistance, disturbed local immunity and impaired neuromotor function are associated with chronic OME.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands. jamengel@wxs.nl
authors.forename: J
authors.initials: J
authors.lastname: Engel
authors.forename: E
authors.initials: E
authors.lastname: Mahler
authors.forename: L
authors.initials: L
authors.lastname: Anteunis
authors.forename: E
authors.initials: E
authors.lastname: Marres
authors.forename: G
authors.initials: G
authors.lastname: Zielhuis
mesh_terms: D002908:Chronic Disease; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D015994:Incidence; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D007440:Intubation; D008297:Male; D015999:Multivariate Analysis; D009468:Neuromuscular Diseases / Q000453:epidemiology; D010034:Otitis Media with Effusion / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D012121:Respiration, Artificial; D012307:Risk Factors