Numerical and experimental investigation of the diffusional release of a dispersed solute from polymeric multilaminate matrices.
In the present work the release behavior of special, multilaminate matrix-type polymer systems, is studied both theoretically and experimentally. Two different mathematical models have been employed to describe the release of a dispersed solute from both single- and multilayer matrices. A parameter sensitivity study shows that the incorporation of supersaturated matrices in the formation of multilaminate devices, with a nonuniform initial solute loading, can provide a delivery system with optimized performance compared to monolithic ones. Finally, the findings of this theoretical analysis show good agreement with measurements of the release rates of a model disperse dye from both single- and multilayer matrices.
Charalambopoulou
G C
GC
National Center for Scientific Research Demokritos, 153 10 Ag. Paraskevi Attikis, Athens, Greece.
Kikkinides
E S
ES
Papadokostaki
K G
KG
Stubos
A K
AK
Papaioannou
A T
AT
D004058:Diffusion; D016503:Drug Delivery Systems; D008433:Mathematics; D008962:Models, Theoretical; D011108:Polymers
D011108:Polymers