A different retinal glia response to optic nerve injury/lipopolysaccharide administration in hooded and albino rats.
Despite a massive degeneration of retinal ganglion cells (RGC) after optic nerve crush (ONC) in hooded rats only a minor increase in retinal glial fibrillary acidic protein (GFAP)-immunoreactivity was found in the inner retina. Interestingly, a combination of ONC with the administration of the proinflammatory agent lipopolysaccharide (LPS) but not LPS alone induces increased GFAP-immunoreactivity. In contrast albino rats showed elevated GFAP-immunoreactivity in response to both, LPS-administration and ONC with no further increase after a combination of both. These data demonstrate significant differences in retinal glia responsiveness between hooded and albino rats after optic nerve lesions.
Engelmann
R
R
Forschergruppe 'Visuelle Entwicklung und Plastizität', Leibniz Institute for Neurobiology, Magdeburg, Germany.
Dieterich
D C
DC
Bien
A
A
Kreutz
M R
MR
D000818:Animals; D015153:Blotting, Western; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D008070:Lipopolysaccharides / Q000633:toxicity*; D008297:Male; D009409:Nerve Crush; D009457:Neuroglia / Q000378:metabolism / Q000473:pathology*; D020221:Optic Nerve Injuries / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012160:Retina / Q000378:metabolism / Q000473:pathology*
D005904:Glial Fibrillary Acidic Protein; D008070:Lipopolysaccharides