The future of gene therapy for stroke.
New diagnostic and treatment strategies are being developed for stroke. Gene therapy has several potential advantages over classical pharmacologic therapy. Direct administration of DNA into the brain offers the advantage of producing high concentrations of therapeutic agents in a relatively localized environment. Gene transfer also provides longer duration of effect than traditional drug therapy. Recent studies indicate that gene transfer can produce functional proteins in brain parenchyma and cerebral blood vessels after stroke. In animal models, gene transfer may reduce effects of cerebral ischemia or subarachnoid hemorrhage. This review summarizes some current methods of gene transfer to the brain and recent progress that may lead to gene therapy for stroke.
Gunnett
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E315B-GH Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242-1081, USA.
Heistad
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D005544:Forecasting; D015316:Genetic Therapy / Q000639:trends*; D006801:Humans; D020521:Stroke / Q000628:therapy*