Effect of long-term exposure to ozone on functional activity of human phagocytes.
Functional activity (biocidal properties) of whole blood phagocytes from humans exposed to ozone was studied by measuring spontaneous and zymosan-induced luminol-dependent chemiluminescence. Generation of reactive oxygen species and biocidal properties of phagocytes depended on the time of ozone exposure and development of bronchopulmonary diseases. The data suggest that generation of reactive oxygen species must be assayed for elaboration of individual patient management programs.
Abdrashitova
N F
NF
Russian State Medical University, Moscow.
Balyakin
Y V
YV
Romanov
Y A
YA
D000328:Adult; D006801:Humans; D008875:Middle Aged; D010083:Oxidants, Photochemical / Q000494:pharmacology*; D010126:Ozone / Q000494:pharmacology*; D010586:Phagocytes / Q000502:physiology*; D010587:Phagocytosis / Q000187:drug effects; D017382:Reactive Oxygen Species; D013997:Time Factors
D010083:Oxidants, Photochemical; D017382:Reactive Oxygen Species; D010126:Ozone