Peripheral T-cell subsets in patients with reticular and atrophic-erosive oral lichen planus.
OBJECTIVE
Oral lichen planus (OLP) presents with various clinical forms that can be classified into 2 major types: reticular OLP and atrophic-erosive OLP. Our objective was to investigate immunologic differences between these 2 types.


METHODS
We investigated possible immunologic differences between 26 patients with reticular OLP and 26 patients with atrophic-erosive OLP.


RESULTS
No differences were detected in serum Ig levels or complement levels. However, the mean proportions of CD4+CD45RO+ and DR+ lymphocytes were significantly higher in patients with atrophic-erosive OLP than in patients with reticular OLP, whereas the mean proportion of CD8+CD45RA+ lymphocytes was significantly lower in patients with atrophic-erosive OLP.


CONCLUSIONS
These findings suggest that the 2 clinical types of OLP might have different immunopathogenic mechanisms.
Rodríguez-Núñez
I
I
University of Santiago de Compostela and Hospital General de Galicia. t155867002@abonados.cplus.es
Blanco-Carrión
A
A
García
A G
AG
Rey
J G
JG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D016009:Chi-Square Distribution; D003176:Complement C3 / Q000276:immunology; D003181:Complement C4 / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D017493:Leukocyte Common Antigens / Q000276:immunology; D017676:Lichen Planus, Oral / Q000145:classification / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D016176:T-Lymphocyte Subsets / Q000145:classification*
D003176:Complement C3; D003181:Complement C4; D006684:HLA-DR Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E; D017493:Leukocyte Common Antigens