Haptoglobin phenotype as a predictor of restenosis after percutaneous transluminal coronary angioplasty.
We have demonstrated that a genetic polymorphism in the antioxidant protein haptoglobin is important in determining which patients develop restenosis after percutaneous transluminal coronary angioplasty. Knowledge of the haptoglobin phenotype may be useful in the assessment and utilization of new therapies to reduce restenosis, particularly in patients who are homozygous for the haptoglobin 2 allele.
Roguin
A
A
Rappaport Faculty of Medicine, Technion-Israel of Technology, Bat Galim.
Hochberg
I
I
Nikolsky
E
E
Markiewicz
W
W
Meisel
S R
SR
Hir
J
J
Grenadier
E
E
Beyar
R
R
Levy
A P
AP
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000235:genetics* / Q000628:therapy; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics; D010641:Phenotype; D012008:Recurrence; D012307:Risk Factors
D006242:Haptoglobins