Mutagenicity studies of FAVOR PAC.
A series of in vitro and in vivo assays have been conducted using FAVOR PAC (CAS Registry No. 9003-04-7), a cross-linked sodium polyacrylate polymer, to test its ability to induce mutations. FAVOR PAC is a member of the FAVOR family of superabsorbent polymers (SAPs) developed by Stockhausen GmbH & Co KG (Krefeld, Germany). These SAPs are known for their ability to retain large volumes of fluid, even against pressure. The genotoxic potential of FAVOR PAC and its extracts was examined in the following five standard mutagenicity assays: the Salmonella typhimurium and Escherichia coli reverse mutation assay, the mouse lymphoma fluctuation assay, the mouse lymphoma forward mutation assay, the in vivo mouse micronucleus assay, and an in vitro rat DNA synthesis assay. Based on the results of these assays, it was concluded that FAVOR PAC was clearly not genotoxic under any of the conditions of the mutagenicity assays performed.
Haselbach
J
J
Stockhausen GmbH & Co KG, 47704 Krefeld, Germany.
Hey
S
S
Diener
B
B
Mehta
N
N
D000180:Acrylic Resins / Q000633:toxicity*; D000818:Animals; D004260:DNA Repair / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008223:Lymphoma / Q000139:chemically induced; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011108:Polymers / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012486:Salmonella typhimurium / Q000187:drug effects
D000180:Acrylic Resins; D009153:Mutagens; D011108:Polymers; C006903:carbopol 940; D007041:Hypoxanthine Phosphoribosyltransferase