Absolute configuration of N-[(-)-2-(7-methoxy-1,2,3,3-tetrahydro-1-naphthyl)ethyl]cyclopropylcarboxamide, a highly potent and selective melatonin analogue.
The title compound, C17H23NO2, a tetrahydronaphthalenic analogue of melatonin, crystallizes in the monoclinic space group P2(1) with one molecule in the asymmetric unit. The crystal structure has been determined by X-ray analysis at room temperature. The absolute configuration of this compound was determined unambiguously as R at the chiral naphthalene C-1 position.
Guelzim
A
A
Laboratoire de Dynamique et Structure des Matériaux Moléculaires ESA 8024, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq CEDEX, France. halim.guelzim@univ-lille1.fr
Belloli
E
E
Yous
S
S
Vaccher
C
C
D003521:Cyclopropanes / Q000737:chemistry*; D008550:Melatonin / Q000031:analogs & derivatives* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*; D014961:X-Ray Diffraction
D003521:Cyclopropanes; C425411:N-((-)-2-(7-methoxy-1,2,3,3-tetrahydro-1-naphthyl)ethyl)cyclopropylcarboxamide; D009281:Naphthalenes; D008550:Melatonin