Calcineurin A and calbindin immunoreactivity in the spinal cord of G93A superoxide dismutase transgenic mice.
A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneurons are affected by the neurodegenerative process; in contrast, calbindin-positive cells are selectively spared. The findings suggest that calcineurin plays a role as an accessory factor responsible for selective vulnerability in the neurodegenerative process of amyotrophic lateral sclerosis.
Knirsch
U
U
Department of Neurology, University of Ulm, Oberer Eselsberg 45, D-89081, Ulm, Germany. ursula.knirsch@medizin.uni-ulm.de
Sturm
S
S
Reuter
A
A
Bachus
R
R
Gosztonyi
G
G
Voelkel
H
H
Ludolph
A C
AC
D000818:Animals; D015153:Blotting, Western; D064026:Calbindins; D019703:Calcineurin / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000235:genetics*
D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D013482:Superoxide Dismutase; D019703:Calcineurin