title: Suppression of hemopoiesis during CCl(4)-induced hepatic fibrosis: role of systemic endotoxemia.
abstract: CCl(4)-induced hepatic fibrosis in mice was accompanied by insufficiency of bone marrow myelo- and erythropoiesis. Polymyxin B completely abolished these changes. This phenomenon can be explained by the development of macrophage endotoxin tolerance during hepatic fibrosis.
authors.affiliation: Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
authors.forename: Y S
authors.initials: YS
authors.lastname: Shvarts
authors.forename: A A
authors.initials: AA
authors.lastname: Zubakhin
authors.forename: M I
authors.initials: MI
authors.lastname: Dushkin
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D019446:Endotoxemia / Q000209:etiology* / Q000473:pathology*; D006410:Hematopoiesis / Q000187:drug effects*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000473:pathology*; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011112:Polymyxin B / Q000494:pharmacology
chemical_list: D002251:Carbon Tetrachloride; D011112:Polymyxin B