Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus in Chinese population.
OBJECTIVE
To investigate the possible association between the Xbal polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus (NIDDM) in Chinese population.


METHODS
216 NIDDM patients and 106 healthy controls were studied. DNA fragment containing Xbal restriction site was amplified by the polymerase chain reaction, digested by the Xbal enzyme and compared by gel electrophoresis with a positive control from Finland.


RESULTS
The Xbal polymorphism was found in 18 of 216 Chinese patients (8.3%) and was also found in 10 of 106 controls (9.4%) (P > 0.05).


CONCLUSIONS
The results suggest that the Xbal polymorphism of the glycogen synthase gene could not be used as a genetic marker for NIDDM in Chinese population of Henan Han nationality.
Wang
C
C
Department of Endocrinology, First Affiliated Hospital, Henan Medical University, Zhengzhou 450052, China.
Bai
Y
Y
Ouyang
A
A
D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics*; D005819:Genetic Markers; D006006:Glycogen Synthase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D006006:Glycogen Synthase; C025580:endodeoxyribonuclease XBAI; D015252:Deoxyribonucleases, Type II Site-Specific