title: Ankyrins and cellular targeting of diverse membrane proteins to physiological sites.
abstract: Ankyrins are spectrin-binding proteins that associate via ANK repeats with a variety of ion channels/pumps, calcium release channels and cell adhesion molecules. Recent studies in mice indicate that ankyrins have a physiological role in restricting voltage-gated sodium channels and members of the L1 CAM family of cell adhesion molecules to excitable membranes in the central nervous system and in targeting calcium-release channels to the calcium homeostasis compartment of striated muscle.
authors.affiliation: Howard Hughes Medical Institute and the Departments of Cell Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA. benne012@mc.duke.edu
authors.forename: V
authors.initials: V
authors.lastname: Bennett
authors.forename: L
authors.initials: L
authors.lastname: Chen
mesh_terms: D000818:Animals; D017487:Ankyrins / Q000737:chemistry / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology; D019143:Evolution, Molecular; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D017487:Ankyrins; D008565:Membrane Proteins