title: Force dependence of the Michaelis constant in a two-state ratchet model for molecular motors.
abstract: We present a quantitative analysis of recent data on the kinetics of ATP hydrolysis, which has presented a puzzle regarding the load dependence of the Michaelis constant. Within the framework of coarse grained two-state ratchet models, our analysis not only explains the puzzling data, but provides a modified Michaelis law, which could be useful as a guide for future experiments.
authors.affiliation: International School of Advanced Studies and Istituto Nazionale di Fisica della Materia, trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Lattanzi
authors.forename: A
authors.initials: A
authors.lastname: Maritan
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D007700:Kinetics; D008962:Models, Theoretical; D020409:Molecular Motor Proteins / Q000378:metabolism*
chemical_list: D020409:Molecular Motor Proteins; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate