Impact of oncogenes and tumor suppressor genes on deregulation of hemostasis and angiogenesis in cancer.
We postulate that oncogenes and tumor suppressor genes may influence tumor angiogenesis not only directly (e.g. by upregulating vascular endothelial growth factor) but also through their impact on expression (and/or function) of tissue factor and other elements of the hemostatic system.
Rak
J
J
Hamilton Civic Hospital Research Centre, McMaster University, Hamilton, Ontario, Canada. jrak@thrombasis.hhscr.org
Klement
G
G
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006487:Hemostasis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000098:blood supply / Q000235:genetics*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000503:physiopathology*; D009857:Oncogenes