A pattern grouping algorithm for analysis of spatiotemporal patterns in neuronal spike trains. 2. Application to simultaneous single unit recordings.
This study demonstrates the practical application of the pattern grouping algorithm (PGA), presented in the companion paper (Tetko IV, Villa AEP. A pattern grouping algorithm for analysis of spatiotemporal patterns in neuronal spike trains. 1. Detection of repeated patterns. J. Neurosci. Methods 2000; accompanying article), to data sets including up to 30 simultaneously recorded spike trains. The analysis of a large network of simulated neurons shows that the incidence of patterns cannot be simply related to an increase in firing rates obtained after Hebbian learning. Patterns that disappeared and reappeared in the thalamus of anesthetized rats when the cerebral cortex was reversibly inactivated suggest that widespread cell assemblies contribute to the generation and propagation of precisely timed activity. In an another experiment multiple spike trains were recorded from the temporal cortex of freely moving rats performing a complex two-choice discrimination task. The presence or absence of particular patterns in the period preceding the cue was associated with changes in reaction time. In conclusion, neuronal network interactions may generate spatiotemporal firing patterns detectable by PGA. We provide evidence of such patterned activity associated with specific animal's behavior, thus suggesting the existence of complex temporal coding schemes in the higher nervous centers of the brain.
Tetko
I V
IV
Laboratoire de Neuro-heuristique, Institut de Physiologie, Université de Lausanne, Rue du Bugnon 7, CH-1005, Lausanne, Switzerland.
Villa
A E
AE
D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology; D001921:Brain / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology; D004594:Electrophysiology / Q000379:methods*; D005829:Geniculate Bodies / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010363:Pattern Recognition, Automated; D051381:Rats; D020318:Rats, Long-Evans; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors