title: Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields.
abstract: Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF-MF). We report that ELF-MF, though not perturbing cell cycle progression, increases the rate of cell death in normal cell lines. In contrast, cell death is not affected in cells from genetic instability syndromes; this reflects a specific failure of the apoptotic response. Reintroduction of complementation group C in FA cells re-established the apoptotic response to ELF-MF. Thus, genes implicated in genetic instability syndromes are relevant in modulating the response of cells to ELF-MF.
authors.affiliation: CNR Centro di Genetica Evoluzionistica c/o Università La Sapienza, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Mangiacasale
authors.forename: A
authors.initials: A
authors.lastname: Tritarelli
authors.forename: I
authors.initials: I
authors.lastname: Sciamanna
authors.forename: M
authors.initials: M
authors.lastname: Cannone
authors.forename: P
authors.initials: P
authors.lastname: Lavia
authors.forename: M C
authors.initials: MC
authors.lastname: Barberis
authors.forename: R
authors.initials: R
authors.lastname: Lorenzini
authors.forename: E
authors.initials: E
authors.lastname: Cundari
mesh_terms: D017209:Apoptosis; D001260:Ataxia Telangiectasia / Q000235:genetics / Q000473:pathology; D002453:Cell Cycle; D016923:Cell Death; D002460:Cell Line; D005199:Fanconi Anemia / Q000235:genetics / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008280:Magnetics / Q000009:adverse effects*; D008854:Microscopy, Electron; D009154:Mutation; D014162:Transfection