Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys.
Six rhesus monkeys were trained to stable performance on neuropsychological tests of memory, reinforcer efficacy, reaction time and bimanual motor coordination. Three monkeys were then exposed to a high-dose, short course regimen of (+/-)3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") (4 days, 10 mg/kg i.m., b.i.d.). Following treatment, concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) were reduced by approximately 50% in the treated animals, and this effect persisted for approximately three months post-MDMA. Behavioral performance was disrupted during acute MDMA treatment but returned to baseline within one week following treatment. MDMA also produced persistent alterations in late peak latencies of brainstem auditory evoked potentials (BSAEP), lasting three months post-MDMA. Both CSF 5-HIAA concentrations and evoked potential latencies were normalized four months after treatment. These findings indicate that serotonergic alterations associated with MDMA use may result in persisting changes in brain function.
Taffe
M A
MA
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA. mtaffe@scripps.edu
Weed
M R
MR
Davis
S
S
Huitrón-Resendiz
S
S
Schroeder
R
R
Parsons
L H
LH
Henriksen
S J
SJ
Gold
L H
LH
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid / Q000737:chemistry; D008253:Macaca mulatta / Q000523:psychology*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000008:administration & dosage / Q000633:toxicity*; D009483:Neuropsychological Tests / Q000592:standards*; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D018817:N-Methyl-3,4-methylenedioxyamphetamine