title: Prevention of acute otitis media by prophylaxis and treatment of influenza virus infections.
abstract: Human experimental challenge studies with influenza virus infection and controlled intervention trials have demonstrated beyond doubt the role of influenza virus infection in the pathogenesis of acute otitis media. Influenza virus infections not only disrupt eustachian tube function, but also impair recovery from infection and facilitate attachment of bacterial pathogens to respiratory epithelial cells. Immunization of young children with either inactivated or live, attenuated influenza vaccine will significantly reduce the incidence of acute otitis media. Early treatment of influenza with antiviral medication will reduce eustachian tube dysfunction that results from influenza virus infection. Influenza produces high morbidity in children that could be averted by universal immunization with attenuated nasal spray vaccine.
authors.affiliation: Molecular Virology and Microbiology, Influenza Research Center at Baylor College of Medicine, One Baylor Plaza, Suite 221D, Houston, TX 77030, USA. wglezen@bcm.tmc.edu
authors.forename: W P
authors.initials: WP
authors.lastname: Glezen
mesh_terms: D000208:Acute Disease; D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002656:Child Day Care Centers; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005064:Eustachian Tube / Q000503:physiopathology; D006801:Humans; D007223:Infant; D009980:Influenza A virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D015337:Multicenter Studies as Topic; D009657:North Carolina / Q000453:epidemiology; D010033:Otitis Media / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D016032:Randomized Controlled Trials as Topic; D013781:Texas / Q000453:epidemiology; D014611:Vaccination
chemical_list: D000336:Aerosols; D000998:Antiviral Agents; D007252:Influenza Vaccines