title: Identification of Perfusion Abnormalities Using FSO69, a Novel Contrast Agent, in Conscious Dogs.
abstract: Recent advances in the production of echocardiographic contrast agents has resulted in the ability to delineate areas of hypoperfusion after coronary occlusions and stenoses following their intravenous injection. Most of these studies though have been done in open chest animals. This study was done to determine if we could assess myocardial perfusion following the intravenous administration of FSO69, a suspension of perfluoropropane filled albumin microspheres (3.6 µm average microbubble size, concentration 8 x 10(8)), in spontaneously breathing closed chest dogs. Twenty-seven mongrel dogs were instrumented on day 1. The chest was then closed and the dogs were restudied 3-7 days later, while spontaneously breathing. Homogeneous perfusion was observed in most dogs by all three independent and blinded observers. Perfusion abnormalities were likewise identified in most instances by all blinded reviewers on interventions designed to decrease regional blood flow. A good correlation between perfusion defect size between investigators was observed. In summary, our data suggest that FSO69 can be used to assess regional myocardial perfusion in spontaneously breathing dogs. These results support its use in humans.
authors.affiliation: Ochsner Medical Institutions 1514 Jefferson Highway, New Orleans, LA 70123.
authors.forename: Sameh
authors.initials: S
authors.lastname: Mobarek
authors.forename: Marc
authors.initials: M
authors.lastname: Kates
authors.forename: Mario
authors.initials: M
authors.lastname: Meza
authors.forename: Carlos
authors.initials: C
authors.lastname: Moreno
authors.forename: Susan
authors.initials: S
authors.lastname: Revall
authors.forename: Wayne
authors.initials: W
authors.lastname: Barbee
authors.forename: Joseph P.
authors.initials: JP
authors.lastname: Murgo
authors.forename: Jorge
authors.initials: J
authors.lastname: Cheirif