title: Gastric intramucosal pH and intraluminal PCO2 during weaning from mechanical ventilation.
abstract: OBJECTIVE
  To study the value of gastric intramucosal pH and gastric intraluminal PCO2 measurements to predict weaning outcome from mechanical ventilation.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  Intensive care medicine department of a university hospital.
  
  
  METHODS
  Nineteen adult critically ill patients who were mechanically ventilated because of acute respiratory failure and were considered ready to be weaned.
  
  
  METHODS
  The patients were weaned with: synchronized intermittent mandatory ventilation plus positive end-expiratory pressure (SIMV+PEEP) or continuous positive airway pressure with pressure support ventilation (CPAP+PSV). A gastric tonometer was placed in all the patients. Tonometric, respiratory, and hemodynamic variables were measured during the weaning process.
  
  
  METHODS
  Hemodynamic variables, respiratory mechanics, pulmonary gas exchange, respiratory muscle force, spontaneous pattern of breathing, and the central control of breathing were recorded. Simultaneously, the intramucosal pH and gastric intraluminal PCO2 were measured.
  
  
  RESULTS
  Eleven patients were successfully extubated and eight failed. The patients who failed showed higher values of mouth occlusion pressure, respiratory rate, and effective inspiratory impedance (mouth occlusion pressure/mean inspiratory flow). The intramucosal pH was initially 7.19 +/- 0.22 and decreased to 7.10 +/- 0.16 during the weaning process in patients who failed (p < .05). At the same time, the intramucosal pH showed a nonsignificant change from 7.36 +/- 0.07 to 7.32 +/- 0.07 in the patients who were successfully extubated. The intramucosal pH was statistically different when both groups were compared during the initial and the final evaluations (p < .05). For the initial evaluation, the sensitivity and specificity to predict weaning failure when the intramucosal pH was < or =7.30 were 0.88 (95% confidence interval [CI], 0.66-1) and 0.82 (95% CI, 0.59-1), respectively. The gastric intraluminal PCO2 was higher in patients who failed (p < .05). When gastric intraluminal PCO2 was . or =40 torr during the initial evaluation, weaning failure occurred with a sensitivity of 1 (95% CI, 0.31-1) and a specificity of 0.55 (95% CI, 0.26-0.84).
  
  
  CONCLUSIONS
  Weaning failure was associated with gastric intramucosal acidosis. The intramucosal pH and gastric intraluminal PCO2 may be helpful to predict weaning outcome. Further controlled clinical trials in a larger group of patients are needed.
authors.affiliation: Department of Intensive Care Medicine, Hospital de Clínicas, School of Medicine, Universidad de la República, Montevideo, Uruguay.
authors.forename: F J
authors.initials: FJ
authors.lastname: Hurtado
authors.forename: M
authors.initials: M
authors.lastname: Berón
authors.forename: W
authors.initials: W
authors.lastname: Olivera
authors.forename: R
authors.initials: R
authors.lastname: Garrido
authors.forename: J
authors.initials: J
authors.lastname: Silva
authors.forename: E
authors.initials: E
authors.lastname: Caragna
authors.forename: D
authors.initials: D
authors.lastname: Rivara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D016013:Likelihood Functions; D008297:Male; D008365:Manometry; D008875:Middle Aged; D010313:Partial Pressure; D012131:Respiratory Insufficiency / Q000517:prevention & control*; D015656:Respiratory Mechanics; D012680:Sensitivity and Specificity; D013152:Splanchnic Circulation; D018709:Statistics, Nonparametric; D015300:Ventilator Weaning
chemical_list: D002245:Carbon Dioxide