Angiogenic gene therapy for heart disease: a review of animal studies and clinical trials.
The current published clinical literature on angiogenic gene therapy for the treatment of myocardial ischemia does not include a single randomized, placebo-controlled trial. Based on current clinical literature, it is an unproven therapy. Successful animal studies combined with published reports of good outcomes in patients enrolled in uncontrolled trials has led to the expectation that angiogenic gene therapy will ultimately become a clinical reality. The next important landmark in the field will be the publication of data showing a favorable effect of angiogenic gene transfer in placebo-controlled, blinded clinical trials.
Hammond
H K
HK
San Diego VA Healthcare System, Department of Medicine, University of California (111A) 3350 La Jolla Village Drive, San Diego, CA 92161, USA. khammond@ucsd.edu
McKirnan
M D
MD
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D003097:Collateral Circulation; D018849:Controlled Clinical Trials as Topic; D003326:Coronary Circulation; D003331:Coronary Vessels; D004247:DNA / Q000008:administration & dosage; D004195:Disease Models, Animal; D016228:Endothelial Growth Factors / Q000235:genetics*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000008:administration & dosage; D006352:Heart Ventricles; D006801:Humans; D007267:Injections; D007269:Injections, Intra-Arterial; D008222:Lymphokines / Q000235:genetics*; D017202:Myocardial Ischemia / Q000628:therapy*; D018919:Neovascularization, Physiologic; D010496:Pericardium; D013552:Swine; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D004247:DNA