Generating diversity at GABAergic synapses.
GABA-mediated transmission is characterized by high variability of synaptic responses. Major contributors to this variability are: presynaptic factors, including release probability and number of release sites; factors that determine synaptic GABA transients in the cleft, including diffusion and the actions of GABA transporters; and postsynaptic factors, including GABA(A) receptors subtypes, their location and number, their modulation by endogenous and exogenous factors, and their interactions with postsynaptic-anchoring proteins.
Cherubini
E
E
Biophysics Sector, International School of Advanced Studies, I-34014 Trieste, Italy.
Conti
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F
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D050485:GABA Plasma Membrane Transport Proteins; D006801:Humans; D008322:Mammals; D008565:Membrane Proteins / Q000502:physiology; D026901:Membrane Transport Proteins; D027361:Organic Anion Transporters; D010802:Phylogeny; D011487:Protein Conformation; D011963:Receptors, GABA-A / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D002352:Carrier Proteins; D050485:GABA Plasma Membrane Transport Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D027361:Organic Anion Transporters; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid