Cardiotropic effects of Met-enkephalin and somatostatin under conditions of neurotensin receptor blockade.
Pretreatment with the neurotensin receptor antagonist decreased the severity and time of Met-enkephalin-induced inhibition of vagal chronotropic effects in cats. The opiate receptor antagonist naloxone produced a delayed inhibitory effect on the synchronizing component of the vagal chronotropic effect under conditions of neurotensin receptor blockade. Cardiotropic effects of somatostatin remained unchanged during neurotensin receptor blockade. These data indicate one-way and two-way interactions between peptides modulating parasympathetic cardiac regulation.
Osadchii
O E
OE
Department of Normal Physiology, Kuban Medical Academy, Krasnodar, Russia.
Totskaya
E K
EK
Pokrovskii
V M
VM
Kurzanov
A N
AN
D000818:Animals; D002415:Cats; D004744:Enkephalin, Methionine / Q000378:metabolism* / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors*; D013004:Somatostatin / Q000378:metabolism* / Q000494:pharmacology; D014630:Vagus Nerve / Q000187:drug effects*
D009292:Narcotic Antagonists; D018028:Receptors, Neurotensin; D009270:Naloxone; D013004:Somatostatin; D004744:Enkephalin, Methionine