title: [Successful treatment for disseminated intra-vascular coagulation due to sepsis and brain abscess with low molecular weight heparin in a patient with antiphospholipid syndrome].
abstract: The management of disseminated intravascular coagulation (DIC) in a 22-year-old female patient with antiphospholipid syndrome is reported. Gabexate mesilate was given by continuous drip infusion at 1.5 g/day. No effect was seen, therefore Dalteparin sodium (DS) was administered by continuous drip infusion at 70 U/kg/day. The DIC score improved gradually during the first 4 days to normalization by 10 days. However, convulsive seizure was developed. Computed tomographic scan of brain demonstrated brain abscess at lt-basal ganglia. Continuous drainage was performed while administered continuous drip infusion of DS. Follow-up CT after operation showed reduction of low density area which means brain abscess. Finding in this case suggest that DS may play a role in the management of DIC accompanying intracranial infection.
authors.affiliation: Third Department of Internal Medicine, Hyogo Medical College.
authors.forename: K
authors.initials: K
authors.lastname: Hiroishi
authors.forename: Y
authors.initials: Y
authors.lastname: Shigenobu
authors.forename: M
authors.initials: M
authors.lastname: Asai
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuzuki
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Tominaga
authors.forename: K
authors.initials: K
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Hada
authors.forename: K
authors.initials: K
authors.lastname: Higashino
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000188:drug therapy*; D001922:Brain Abscess / Q000150:complications*; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D018805:Sepsis / Q000150:complications*
chemical_list: D005343:Fibrinolytic Agents; D006495:Heparin, Low-Molecular-Weight