title: Current and novel approaches to the drug treatment of schizophrenia.
authors.affiliation: Merck Sharp and Dohme, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. Michael_Rowley@Merck.com
authors.forename: M
authors.initials: M
authors.lastname: Rowley
authors.forename: L J
authors.initials: LJ
authors.lastname: Bristow
authors.forename: P H
authors.initials: PH
authors.lastname: Hutson
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D018679:Cholinergic Agonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D044402:Receptor, Serotonin, 5-HT2A; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D050638:Receptors, Dopamine D4; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D018028:Receptors, Neurotensin / Q000819:agonists; D011985:Receptors, Serotonin / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D018679:Cholinergic Agonists; C493599:DRD4 protein, human; D018492:Dopamine Antagonists; C493600:Drd4 protein, mouse; D004791:Enzyme Inhibitors; D018691:Excitatory Amino Acid Antagonists; D044402:Receptor, Serotonin, 5-HT2A; D018091:Receptors, AMPA; D017448:Receptors, Dopamine D2; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D018028:Receptors, Neurotensin; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C114036:neurotensin type 1 receptor; D050638:Receptors, Dopamine D4; D019001:Nitric Oxide Synthase