Response to Kondrashov.
The 'mutational deterministic' hypothesis proposes that a high genomic rate of deleterious mutation (U) might maintain sexual reproduction. Our recent work casts doubt on this, as we estimate a low U for sexually reproducing species with short generation times. Following criticism by Kondrashov, here we defend our methods for estimating U and challenge the mutational deterministic hypothesis.
Keightley
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PD
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, EH9 3JT, Edinburgh, UK. p.keightley@ed.ac.uk
Eyre-Walker
A
A
D000818:Animals; D005075:Biological Evolution; D003062:Codon; D006801:Humans; D009154:Mutation; D012744:Sex Ratio
D003062:Codon