Mechanisms of motor protein reversal.
Members of the kinesin superfamily of microtubule-based motors and the myosin superfamily of actin-based motors that move 'backwards' have been identified. As the core catalytic domains of myosins and kinesins are similar in structure, this raises the intriguing questions of how direction reversal is accomplished and whether kinesins and myosins share mechanisms for switching their motors into reverse.
Hasson
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Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, California 92093-0368, USA. tama@ucsd.edu
Cheney
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D000818:Animals; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology
D020409:Molecular Motor Proteins