Biochemical changes induced in liver and serum of aflatoxin B1-treated male wistar rats: preventive effect of picroliv.
Administration of aflatoxin B1 to rats (2 mg/kg intraperitoneally) caused significant increase in the activities of gamma-glutamyl transpeptidase, 5'-nucleotidase, acid phosphatase, acid ribonuclease as well as content of lipid peroxides in liver after six weeks. However, the activities of succinate dehydrogenase, glucose-6-phosphatase, catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase and glutathione reductase in liver were decreased. The levels of glycogen and reduced glutathione were also decreased. There were significant elevations in the levels of serum transaminases, phosphatases (acid and alkaline), dehydrogenases (sorbitol, lactate and glutamate) and bilirubin following aflatoxin B1 administration. Picroliv (25 mg/kg/day orally for six weeks), an iridoid glycoside isolated from the roots and rhizomes of Picrorhiza kurroa, significantly prevented the biochemical changes induced by aflatoxin B1.
Rastogi
R
R
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Srivastava
A K
AK
Rastogi
A K
AK
D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000517:prevention & control*; D002934:Cinnamates / Q000494:pharmacology*; D004347:Drug Interactions; D004798:Enzymes / Q000097:blood*; D005978:Glutathione / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006027:Glycosides / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014641:Vanillic Acid / Q000494:pharmacology*
D002934:Cinnamates; D004798:Enzymes; D006027:Glycosides; D010936:Plant Extracts; C057463:kutkin; D006003:Glycogen; D016604:Aflatoxin B1; D005978:Glutathione; D014641:Vanillic Acid