Microbial models of mammalian metabolism: microbial transformation of naproxen.
Preparative-scale fermentation of S-naproxen, the known antiinflammatory, analgesic and antipyretic drug, with Cunninghamella elegans ATCC 9245 afforded S-demethylnaproxen, the known human active metabolite of naproxen, in a 90% yield. Demethylnaproxen was also detected as the major metabolite of naproxen using Cunninghamella blakesleeana ATCC 8688a. A review of the previous microbial metabolism studies using the fungi Cunninghamella species suggested that it could be a plausible in vitro predictor for mammalian metabolism.
el Sayed
K A
KA
Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saud University, Saudi Arabia. elsayed99@yahoo.com
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism*; D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008322:Mammals / Q000378:metabolism*; D008954:Models, Biological; D009288:Naproxen / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen