title: [Evaluation of indications and the perspectives of limb salvage surgery in malignant bone tumours in children and youth].
abstract: Malignant bone tumours constitute about 7% of paediatric cancer. Within the last 20 years much has changed in cancer treatment. Neoadjuvant chemotherapy, the first phase of comprehensive treatment, results in regression of the tumour. This makes limb salvage surgery possible. At the National Research Institute of Mother and Child more than 250 patients with malignant bone tumours were treated. In this group there were 131 limb salvage operations. The analysis includes 117 patients with osteogenic sarcoma, 46 with Ewing sarcoma, 7 with chondro-sarcoma, treated between 1985 and 1995. Five years survival was achieved in 74.5% osteogenic sarcoma patients and 41.3% Ewing sarcoma patients.
authors.affiliation: Klinika Chirurgii Onkologicznej Dzieci, Instytut Matki i Dziecka w Warszawie, ul. Kasprzaka 17a, 01-211 Warszawa, Polska. imid@imid.med.pl
authors.forename: W
authors.initials: W
authors.lastname: Wozniak
authors.forename: M
authors.initials: M
authors.lastname: Rychlowska
authors.forename: M
authors.initials: M
authors.lastname: Kuczabski
authors.forename: A
authors.initials: A
authors.lastname: Szafranski
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001859:Bone Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D002813:Chondrosarcoma / Q000188:drug therapy / Q000601:surgery*; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery*; D011292:Premedication; D012189:Retrospective Studies; D016879:Salvage Therapy; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000601:surgery*; D015996:Survival Rate
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate