[Overexpression of cyclin D1 in laryngeal carcinomas].
Cyclin D1 is a set of periodic protein which governs G1 progression. Cyclin D1 gene is localized on chromosome 11q13 which encodes a 295-aa protein. Overexpression of cyclin D1 leads to abnormal cellular proliferation. Which underlies processes of tumorigenesis. In this paper twenty-five fresh specimens of laryngeal carcinomas were examined by means of immune flurescence technique. Overexpression of cyclin D1 was found in 9 of 16 laryngeal carcinomas (37%). There was no statistical correlation between overexpression of cyclin D1 and TNM staging, differentiation grading (P > 0.05). Normal tissue adjacent to tumors lacked any detectable cyclin D1 expression or rare scattered positive cells. It was likely that cyclin D1 overexpression wasn't an early event in processes of tumorigenesis and tumor progression. Follow-up investigation demonstrated that tumors recurred in 4 of 9 primary tumors overexpressing cyclin D1. But only 1 of 16 that expressed cyclin D1-negative. There was statistical significance between them, so overexpression of cyclin D1 could serve as a new prognostic marker.
Zhou
W
W
Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Zhong
R
R
Tan
S
S
D019938:Cyclin D1 / Q000096:biosynthesis*; D004311:Double-Blind Method; D005500:Follow-Up Studies; D015870:Gene Expression; D019940:Genes, bcl-1; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D011379:Prognosis
D019938:Cyclin D1