title: Pathomorphological characteristics of experimental toxemia induced by thermostable Yersinia pseudotuberculosis toxin.
abstract: Pathogenic properties of thermostable toxin responsible for pathogenicity of Yersinia pseudotuberculosis were experimentally studied. The toxin exerted a pronounced polyorgan cytopathogenic effect with predominating degenerative destructive changes and membranolytic effect on cell ultrastructure of parenchymatous organs. The toxin is believed to be directly involved in the development of typical pathomorphological picture of pseudotuberculosis, which confirms its pathogenetic role.
authors.affiliation: Institute of Epidemiology and Microbiology, Siberian Division, Russian Academy of Medical Sciences, Vladivostok, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Isachkova
authors.forename: N F
authors.initials: NF
authors.lastname: Timchenko
authors.forename: E P
authors.initials: EP
authors.lastname: Nedashkovskaya
authors.forename: S D
authors.initials: SD
authors.lastname: Raznik
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000008:administration & dosage / Q000633:toxicity*; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D004768:Enterotoxins / Q000008:administration & dosage / Q000633:toxicity*; D005704:Gallbladder / Q000187:drug effects / Q000473:pathology; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D051379:Mice; D009206:Myocardium / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D014115:Toxemia / Q000473:pathology*; D015011:Yersinia pseudotuberculosis
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; C048669:heat-stable enterotoxin (Yersinia)