Introduction: markers of oxidative damage and antioxidant modulation.
The question of the function of antioxidants in human health can only be resolved when validated markers of oxidative damage are available. Markers allow determination of the effect of antioxidants on damage to DNA, proteins, and lipids. The final goal is the execution of human intervention studies based on markers that are clearly linked to physiological function. These data will be critical in determining the effectiveness of nutrients in promoting health and wellbeing and reducing disease risk.
Diplock
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International Antioxidant Research Centre, Guy's, King's College and St. Thomas's Hospitals Medical and Dental School, Guy's Hospital, London, UK.
D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D015415:Biomarkers; D004249:DNA Damage / Q000187:drug effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*
D000975:Antioxidants; D015415:Biomarkers