title: The EGF and FGF receptors mediate neuroglian function to control growth cone decisions during sensory axon guidance in Drosophila.
abstract: Cell adhesion molecules (CAMs) implement the process of axon guidance by promoting specific selection and attachment to substrates. We show that, in Drosophila, loss-of-function conditions of either the Neuroglian CAM, the FGF receptor coded by the gene heartless, or the EGF receptor coded by DER display a similar phenotype of abnormal substrate selection and axon guidance by peripheral sensory neurons. Moreover, neuroglian loss-of-function phenotype can be suppressed by the expression of gain-of-function conditions of heartless or DER. The results are consistent with a scenario where the activity of these receptor tyrosine kinases is controlled by Neuroglian at choice points where sensory axons select between alternative substrates for extension.
authors.affiliation: Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, 03550, San Juan de Alicante, Spain. lgalonso@umh.es
authors.forename: L
authors.initials: L
authors.lastname: García-Alonso
authors.forename: S
authors.initials: S
authors.lastname: Romani
authors.forename: F
authors.initials: F
authors.lastname: Jiménez
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000648:ultrastructure; D004330:Drosophila; D029721:Drosophila Proteins; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism*; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D009154:Mutation; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism*; D009475:Neurons, Afferent / Q000166:cytology / Q000378:metabolism; D010641:Phenotype; D011505:Protein-Tyrosine Kinases; D011679:Pupa / Q000166:cytology / Q000235:genetics / Q000378:metabolism; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D017468:Receptors, Fibroblast Growth Factor; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; C102667:htl protein, Drosophila