Ictal brain hemodynamics in the epileptic focus caused by a brain tumor using functional magnetic resonance imaging (fMRI).
Using functional magnetic resonance imaging (fMRI) we were able to observe, in detail, ictal brain hemodynamics during epileptic seizure caused by a brain tumor. A 53-year-old man was experencing partial motor seizures of the left side of his face and neck. In a brain MR image a mass lesion was found in the subcortical area of the right frontal lobe. We found focal spikes in his right hemisphere, though dominantly in C4 and T4 regions. fMRI investigations were carried out at 1.5 T (GE Signa Horizon) using gradient-echo echo-planar neuroimaging. We were able to perform the ictal examination twice. The activated regions were focalized and clearly found only on the lateral side of the tumor base. The region was in agreement with the epileptic focus examined using an electrocorticogram (ECOG). The signal intensity in the seizure focus rapidly increased 30 seconds before the convulsion was observed. After the end of the convulsion it also took 30 seconds to restore the signal intensity to the baseline value. fMRI is a very useful tool for various studies such as the identification of the epileptic focus, the mechanism of epileptic seizure, and so on.
Kubota
F
F
Department of Neuropsychiatry, Graduate School of Medical Science, Gunma University, 39-15, Showa-machi 3-Chome, Maebashi-shi, Gunma, 371-8511, Japan. kubota@showa.gunma-u.ac.jp
Kikuchi
S
S
Ito
M
M
Shibata
N
N
Akata
T
T
Takahashi
A
A
Sasaki
T
T
Oya
N
N
Aoki
J
J
D001931:Brain Mapping; D001932:Brain Neoplasms / Q000098:blood supply* / Q000175:diagnosis; D004292:Dominance, Cerebral / Q000502:physiology*; D017352:Echo-Planar Imaging; D004569:Electroencephalography; D020938:Epilepsy, Partial, Motor / Q000175:diagnosis / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D005625:Frontal Lobe / Q000098:blood supply*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000098:blood supply; D012039:Regional Blood Flow / Q000502:physiology