title: Mycobacterium tuberculosis in the post-genomic age.
abstract: Since the publication of the complete genome sequence of Mycobacterium tuberculosis in 1998, there has been a marked intensification and diversification of activities in the field of tuberculosis research. Among the areas that have advanced spectacularly are comparative genomics, functional genomics-notably the study of the transcriptome and proteome - and cell envelope biogenesis, especially as it relates to the mechanism of action of antimycobacterial drugs.
authors.affiliation: Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Cedex 15, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Domenech
authors.forename: C E
authors.initials: CE
authors.lastname: Barry
authors.forename: S T
authors.initials: ST
authors.lastname: Cole
mesh_terms: D000940:Antigenic Variation; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D020543:Proteome; D014158:Transcription, Genetic; D014376:Tuberculosis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology
chemical_list: D020543:Proteome