[Bcl-2 oncoprotein expression in head and neck malignant neoplasm].
To investigate the expression of the apoptosis-suppressing protein Bcl-2 in head and neck neoplasm and the relationship between Bcl-2 and p53 oncoprotein, 90 malignant tumours and 20 benign diseases were studied with immunohistochemical LSAB(labeled streptavidin biotin) method. The results indicated that 48.9% (44/90) cases of head and neck malignant tumours were Bcl-2 positive, and all benign diseases were negative. The expression rate of Bcl-2 in head and neck squamous carcinoma (59.6%) was obviously higher than adenocarcinoma (24.8%), undifferentiated tumour (33.3%) and malignant lymphoma (P < 0.05). The expression rate of Bcl-2 in p53-positive tumours was significantly higher in p53-negative neoplasm. The positive rate of Bcl-2 oncoprotein was not connected with clinical stage and pathological grade. The positive staining intensity was significantly related with clinical stage. This study suggested that Bcl-2 oncoprotein may play an important role in the development of head and neck tumour.
Lei
Z
Z
Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
Liu
Q
Q
D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D006258:Head and Neck Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000737:chemistry / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53