Mycobacterium tuberculosis in the post-genomic age.
Since the publication of the complete genome sequence of Mycobacterium tuberculosis in 1998, there has been a marked intensification and diversification of activities in the field of tuberculosis research. Among the areas that have advanced spectacularly are comparative genomics, functional genomics-notably the study of the transcriptome and proteome - and cell envelope biogenesis, especially as it relates to the mechanism of action of antimycobacterial drugs.
Domenech
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Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Cedex 15, Paris, France.
Barry
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Cole
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D000940:Antigenic Variation; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity; D020543:Proteome; D014158:Transcription, Genetic; D014376:Tuberculosis / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology
D020543:Proteome