title: Long-term followup of newborns with myelodysplasia and normal urodynamic findings: Is followup necessary?
abstract: OBJECTIVE
  A subset of newborns with myelodysplasia have normal bladder function on urodynamic assessment. We analyzed long-term followup in this population to determine the necessity for subsequent urological surveillance.
  
  
  METHODS
  We retrospectively analyzed the records of 25 of 204 newborns (12%) with myelodysplasia in whom neurourological evaluation was normal after surgical repair of the spinal defect. Initial assessment included complete urodynamic study, renal ultrasound, urinalysis and urine culture. These patients were reevaluated every 3 months until age 3 years, semiannually until age 6 years and yearly thereafter. The longest followup was 18.6 years.
  
  
  RESULTS
  Of the 25 newborns 22 had myelomeningocele and 3 had meningocele. During a mean followup of 9.1 years urodynamics subsequently showed neurourological deterioration in 8 children (32%). No changes in urodynamics were observed in any patient older than 6 years. All children with neurourological deterioration underwent magnetic resonance imaging, which confirmed a tethered spinal cord that was then surgically corrected. After the untethering procedure 2 patients (25%) regained normal voiding function, whereas in 6 (75%) mild or moderate neurogenic bladder dysfunction persisted.
  
  
  CONCLUSIONS
  Newborns with myelodysplasia and initially normal urodynamic studies are at risk for neurological deterioration secondary to spinal cord tethering, especially during the first 6 years of life. Close followup of these children is important for the early diagnosis and timely surgical correction of tethered spinal cord, and for the prevention of progressive urinary tract deterioration.
authors.affiliation: Departments of Urology and Neurology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: T
authors.initials: T
authors.lastname: Tarcan
authors.forename: S
authors.initials: S
authors.lastname: Bauer
authors.forename: E
authors.initials: E
authors.lastname: Olmedo
authors.forename: S
authors.initials: S
authors.lastname: Khoshbin
authors.forename: M
authors.initials: M
authors.lastname: Kelly
authors.forename: M
authors.initials: M
authors.lastname: Darbey
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009436:Neural Tube Defects / Q000503:physiopathology*; D012189:Retrospective Studies; D013997:Time Factors; D014563:Urodynamics