The ligand that came from within.
Recent evidence suggests that the endogenous activators of neuronal vanilloid (capsaicin) receptors should be sought inside, not outside, the neuron. 12-Lipoxygenase metabolites of arachidonic acid, produced by pain-inducing mediators such as bradykinin, might trigger vanilloid receptor activation by interacting with an intracellular site on the receptor. Are these lipid-like second messengers the long-sought endogenous vanilloids?
Piomelli
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Department of Pharmacology, 360 MSRII, University of California, Irvine, CA 92697-4625, USA. piomelli@uci.edu
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D009619:Nociceptors / Q000378:metabolism / Q000502:physiology; D011955:Receptors, Drug / Q000378:metabolism / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology; D050916:TRPV Cation Channels
D015289:Leukotrienes; D008054:Lipid Peroxides; D011955:Receptors, Drug; D050916:TRPV Cation Channels; C494484:TRPV1 receptor; D016718:Arachidonic Acid; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid