title: [Acute eosinophilic pneumonia induced by cigarette smoking: positive lymphocyte stimulation test of a cigarette extract].
abstract: A 21-year-old man was admitted to our hospital with high fever, general fatigue and dyspnea. Chest radiography on admission showed diffuse bilateral infiltrate shadows with Kerley's B lines, and a CT scan showed patches of infiltrates with thickened interlobular septa in both lungs. Examination of the bronchoalveolar lavage fluid and the clinical course led to a diagnosis of acute eosinophilic pneumonia. The patient improved without steroid therapy. We suspected that the disease was related to smoking because the patient had started smoking seven days before the onset of the symptoms. Because a lymphocyte stimulation test gave a positive reaction to a cigarette extract, a challenge test was done. After this, the patient had fever and hypoxemia. These findings suggest that cigarette smoking induces acute eosinophilic pneumonia.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, 930-0194, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Matsui
authors.forename: N
authors.initials: N
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
authors.forename: J
authors.initials: J
authors.lastname: Araya
authors.forename: H
authors.initials: H
authors.lastname: Oda
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Miwa
authors.forename: R
authors.initials: R
authors.lastname: Hayashi
authors.forename: N
authors.initials: N
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Kashii
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000208:Acute Disease; D000328:Adult; D006801:Humans; D007159:Immunologic Tests; D008213:Lymphocyte Activation; D008297:Male; D010936:Plant Extracts / Q000276:immunology*; D010947:Plants, Toxic; D011657:Pulmonary Eosinophilia / Q000209:etiology* / Q000276:immunology; D012907:Smoking / Q000009:adverse effects*; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D010936:Plant Extracts