title: Modification of Acute and Chronic Liver Damage by Thiazolidine Compounds.
abstract: As high sulfhydril levels were shown to reduce the action of agents causing tissueinjury, increasing glutathion concentrations may have cytoprotective potential. In this study the hepatoprotective effects of several derivatives of 4carboxy5,5dimethyl thiazolidine, a modulator of glutathion metabolism were studied in rat liver damaged with CCl4. It was found that 4(S) carboxy 5,5dimethyl2 (5'nitro2furyl) thiazolidine (dimethylthiazolidinenitrofuran: DTNF) had the most significant hepatoprotective action; therefore it was subjected to detailed investigation in various models for acute and chronic liver injury. This compound was shown to ameliorate allylalcohol induced liver injury in rats, galactosamine induced hepatitis of mice and CCl4 induced chronic liver damage in rats. Our study on protein synthesis in primary hepatocyte suspension culture showed that cell injury induced by CCl4 could be reduced in the presence of this thiazolidine compound.
authors.affiliation: Semmelweis University of Medicine, 1st Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Divald
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Györgydeák
authors.forename: Ferenc
authors.initials: F
authors.lastname: Tímár
authors.forename: Attila
authors.initials: A
authors.lastname: Zalatnai
authors.forename: Rezsô
authors.initials: R
authors.lastname: Bognár
authors.forename: Gábor
authors.initials: G
authors.lastname: Horváth
authors.forename: Károly
authors.initials: K
authors.lastname: Lapis
authors.forename: András
authors.initials: A
authors.lastname: Jeney