title: Capillary blood pressure in the endocrine and exocrine parenchyma of rat pancreas transplants.
abstract: BACKGROUND
  Transplantation of isolated organs or cells leads to a functional denervation of the organ, which may cause a hyperperfusion of blood. The current study evaluated to what extent blood perfusion and capillary blood pressures were affected in the transplanted rat pancreas.
  
  
  METHODS
  Inbred, male Wistar-Furth rats underwent transplantation with a syngeneic pancreaticoduodenal graft. Four weeks later, blood flow to the native and transplanted pancreases was measured with a microsphere technique. Capillary pressures were measured by direct micropuncture technique.
  
  
  RESULTS
  An increased islet blood flow was consistently observed in the transplanted pancreas as compared with the native organ, while whole pancreatic and duodenal blood flow was similar in the native and transplanted organs. The capillary pressure was twice as high in the exocrine pancreas (6-7 mm Hg) of both the native and transplanted glands when compared with that of the islets (approximately 3 mm Hg). There were no differences in the capillary pressures in either the islets or exocrine gland when native and transplanted pancreases were compared.
  
  
  CONCLUSIONS
  We conclude that the transplanted whole pancreas retains a low islet capillary blood pressure after transplantation despite having a higher islet blood perfusion.
authors.affiliation: Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Jansson
authors.forename: P O
authors.initials: PO
authors.lastname: Carlsson
authors.forename: B
authors.initials: B
authors.lastname: Bodin
authors.forename: A
authors.initials: A
authors.lastname: Andersson
authors.forename: O
authors.initials: O
authors.lastname: Källskog
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002196:Capillaries / Q000503:physiopathology; D007422:Intestines / Q000098:blood supply; D007515:Islets of Langerhans / Q000098:blood supply / Q000294:innervation; D008297:Male; D010179:Pancreas / Q000098:blood supply* / Q000294:innervation; D016035:Pancreas Transplantation; D051381:Rats; D011920:Rats, Inbred WF; D012039:Regional Blood Flow; D013997:Time Factors