title: Oral probiotics can resolve urogenital infections.
abstract: We report the first clinical evidence that probiotic lactobacilli can be delivered to the vagina following oral intake. In 10 women with a history of recurrent yeast vaginitis, bacterial vaginosis (BV) and urinary tract infections, strains Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 suspended in skim milk and given twice daily for 14 days, were recovered from the vagina and identified by morphology and molecular typing within 1 week of commencement of therapy. In six cases of asymptomatic BV or intermediate BV (based upon Nugent scoring) was resolved within 1 week of therapy.
authors.affiliation: Lawson Research Institute, London, Ont., Canada. gregor@julian.uwo.ca
authors.forename: G
authors.initials: G
authors.lastname: Reid
authors.forename: A W
authors.initials: AW
authors.lastname: Bruce
authors.forename: N
authors.initials: N
authors.lastname: Fraser
authors.forename: C
authors.initials: C
authors.lastname: Heinemann
authors.forename: J
authors.initials: J
authors.lastname: Owen
authors.forename: B
authors.initials: B
authors.lastname: Henning
mesh_terms: D000284:Administration, Oral; D001424:Bacterial Infections / Q000382:microbiology / Q000628:therapy*; D005260:Female; D052776:Female Urogenital Diseases / Q000382:microbiology / Q000628:therapy*; D006801:Humans; D007778:Lactobacillus / Q000145:classification / Q000302:isolation & purification; D019936:Probiotics / Q000627:therapeutic use*; D014621:Vagina / Q000382:microbiology