Chemotherapy in the treatment of locally advanced cervical cancer and pregnancy.
BACKGROUND
Carcinoma of the cervix is the most common malignant tumor associated with pregnancy. The initial stages and premalignant lesions apparently present the same prognosis in pregnant and nonpregnant women; however, there are limited data regarding outcome for locally advanced cervical cancer in pregnancy.


METHODS
A 26-year-old woman, gravida 4, para 3, at 14 weeks and 4 days' gestation, was diagnosed with a FIGO stage IIB squamous cell carcinoma of the cervix, treated by primary chemotherapy with cisplatin and bleomycin, until pregnancy resolution at 38 weeks. The newborn infant is currently 3 years old and presents no evidence of abnormalities in neuropsychomotor development.


CONCLUSIONS
The present case demonstrates that chemotherapy was harmless for the child up to the present time. However, a longer follow-up is needed to determine the safe outcome of this child.
Marana
H R
HR
Department of Gynecology and Obstetrics of the Medical School of Ribeirão Preto, University of São Paulo, SP 14.049-900, Brazil. heitorrcm@highnet.com.br
de Andrade
J M
JM
da Silva Mathes
A C
AC
Duarte
G
G
da Cunha
S P
SP
Bighetti
S
S
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology