Therapeutic progress of two sibling cases exhibiting sleep-wake rhythm disorder.
In this study, two females, siblings who exhibited a non-24 h sleep-wake rhythm (non-24 h) at home were observed. However, they showed a delayed sleep phase syndrome (DSPS) immediately after admission to Kurume University Hospital. Melatonin (3 mg) was commenced following chronotherapy and this improved their sleep-wake rhythm. Polysomnography (PSG) showed decreased sleep latency and increased sleep stage. In these cases, the involvement of environmental factors was strongly suggested for the sleep-wake rhythm abnormalities as well as familial factors.
Mukai
M
M
Department of Neuropsychiatry, Kurume University, School of Medicine, Fukuoka, Japan. mukai.m@dream.ocn.ne.jp
Uchimura
N
N
Takeuchi
N
N
Waseda
Y
Y
Takaishi
J
J
Sakamoto
T
T
Maeda
H
H
D000293:Adolescent; D005260:Female; D006801:Humans; D008550:Melatonin / Q000008:administration & dosage*; D017286:Polysomnography; D012892:Sleep Deprivation; D020178:Sleep Disorders, Circadian Rhythm / Q000235:genetics* / Q000628:therapy; D016896:Treatment Outcome
D008550:Melatonin