[Influence of moderate hypothermia on the contents of 6-KETO-PGF1 alpha and TXB2 in brain tissues after cardiac arrest and resuscitation in dogs].
To investigate the effect of moderate hypothermia of whole brain (30 degrees C to 32 degrees C) on the levels of prostacyclin and thromboxane A2 in brain tissues after cardiac arrest and resuscitation. Twenty-one dogs were divided into four groups: Group A, nonischemic controls (n = 4); Group B, 15 minute cardiac arrest without reperfusion (n = 4); Group C, 15 minute cardiac arrest and standard resuscitation (n = 6); Group D, 15 minute cardiac arrest and moderate hypothermia (30 degrees C-32 degrees C). The results showed that as compared with those in Group A, the 6-Keto-PGF1 alpha levels remained substantially unchanged in Group C and D (P > 0.05), and the levels of TXB2 and TXB2/6-Keto-PGF1 alpha ratio increased significantly in Group C (P < 0.01), but both maintained basically stable in Group D (P > 0.05). In comparison with those in Group C, the levels of TXB2 and TXB2/6-Keto-PGF1 alpha ratio decreased dramatically (P < 0.01). It is concluded that the moderate hypothermia can depress the arachidonic acid metabolism and keep a certain balance between the activities of TXA2 and PGI2 during cerebral resuscitation.
Guo
Q
Q
Department of Anesthesiology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Tan
X
X
Cai
H
H
Lei
B
B
Xu
Q
Q
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism*; D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000378:metabolism*; D016887:Cardiopulmonary Resuscitation; D004285:Dogs; D005260:Female; D006323:Heart Arrest / Q000378:metabolism*; D007036:Hypothermia, Induced / Q000379:methods; D008297:Male; D013929:Thromboxane B2 / Q000378:metabolism*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha