title: Pathogenesis of calcium pyrophosphate crystal deposition disease.
abstract: Calcium pyrophosphate dihydrate deposition (CPPDD) disease is an increasingly common form of arthritis affecting the elderly. It is characterized by the formation of CPPD crystals in articular cartilage and usually results in severe cartilage destruction with loss of joint function. This article discusses our understanding of how and why these crystals form, highlighting recent developments in the field.
authors.affiliation: The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin, 5000 W. National Ave., Milwaukee, WI 53295-1000, USA. akrose@mcw.edu
authors.forename: A K
authors.initials: AK
authors.lastname: Rosenthal
mesh_terms: D000368:Aged; D002358:Cartilage, Articular / Q000737:chemistry / Q000378:metabolism; D002805:Chondrocalcinosis / Q000209:etiology*; D003460:Crystallization; D006801:Humans; D011503:Transglutaminases / Q000378:metabolism
chemical_list: D011503:Transglutaminases