title: Serum p53 antibodies in small cell lung cancer: the lack of prognostic relevance.
abstract: Prognostic relevance of serum p53 antibodies was assessed in 96 patients with microscopically proven small cell lung cancer (SCLC). The study group included 67 males and 29 females; mean age 58 years; range 35--86 years; 60 with limited disease (LD), and 36 with extensive disease (ED). The control group consisted of 41 patients with non-malignant diseases. The presence of p53 antibodies was assayed by the immunoenzymatic method (P53 ELISA kit, PharmaCell, France). Antibodies were present in 26 SCLC cases (27%); 15 (25%) in LD and 11 (31%) in ED. Antibodies were also found in one out of 41 control subjects (2%). There was no correlation between the level of antibodies and clinical characteristics of SCLC patients including age, gender and extent of disease. The median follow-up for the entire group was 30 months (range: 11--39 months). By the time of analysis, 78 patients (82%) had deceased. Median survival in SCLC patients with and without antibodies was 42 and 39 weeks, respectively (log rank, P=0.81). These results indicate the lack of clinical relevance of serum p53 antibodies in SCLC.
authors.affiliation: Department of Pneumonology, Medical University of Gdańsk, 7 Debinki St, 80-211, Gdańsk, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Jassem
authors.forename: J
authors.initials: J
authors.lastname: Bigda
authors.forename: R
authors.initials: R
authors.lastname: Dziadziuszko
authors.forename: B
authors.initials: B
authors.lastname: Schlichtholz
authors.forename: D
authors.initials: D
authors.lastname: Le Roux
authors.forename: T
authors.initials: T
authors.lastname: Grodzki
authors.forename: W
authors.initials: W
authors.lastname: Rzyman
authors.forename: K
authors.initials: K
authors.lastname: Konopa
authors.forename: M
authors.initials: M
authors.lastname: Poberezna
authors.forename: Z
authors.initials: Z
authors.lastname: Dobrzańska
authors.forename: J
authors.initials: J
authors.lastname: Skokowski
authors.forename: T
authors.initials: T
authors.lastname: Soussi
authors.forename: J
authors.initials: J
authors.lastname: Jassem
mesh_terms: D000328:Adult; D000368:Aged; D000912:Antibodies, Neoplasm / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*
chemical_list: D000912:Antibodies, Neoplasm; D016159:Tumor Suppressor Protein p53