title: Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population.
abstract: In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of gamma-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.
authors.affiliation: Department of Public Health, Fujita Health University School of Health Sciences, Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan. yoshiito@fujita-hu.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Imai
authors.forename: H
authors.initials: H
authors.lastname: Sakamoto
authors.forename: H
authors.initials: H
authors.lastname: Nakano
mesh_terms: D015126:8,11,14-Eicosatrienoic Acid / Q000097:blood; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D004281:Docosahexaenoic Acids / Q000097:blood; D015777:Eicosanoids / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D005757:Gastritis, Atrophic / Q000097:blood* / Q000208:ethnology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D017678:Sex Distribution; D017965:gamma-Linolenic Acid / Q000097:blood
chemical_list: D015777:Eicosanoids; D005231:Fatty Acids, Unsaturated; D004281:Docosahexaenoic Acids; D017965:gamma-Linolenic Acid; D015126:8,11,14-Eicosatrienoic Acid