title: Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET.
abstract: Acetylcholinesterase (AChE) activities in the brain of three patients with AD were measured once before and once during donepezil treatment (5 mg/d in two patients, 3 mg/d in one patient) using PET and N-[11C]methylpiperidin-4-yl acetate. Donepezil reduced k(3) values, an index of AChE activity, in the cerebral cortex by 39 +/- 5%. All patients showed some degree of symptomatic improvement, and it was concluded that this improvement was likely caused by improved cholinergic activity by inhibition of AChE in the brain.
authors.affiliation: Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Shinotoh
authors.forename: A
authors.initials: A
authors.lastname: Aotsuka
authors.forename: K
authors.initials: K
authors.lastname: Fukushi
authors.forename: S
authors.initials: S
authors.lastname: Nagatsuka
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Ota
authors.forename: S
authors.initials: S
authors.lastname: Tanada
authors.forename: T
authors.initials: T
authors.lastname: Irie
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000201:enzymology; D001921:Brain / Q000000981:diagnostic imaging / Q000201:enzymology*; D000077265:Donepezil; D005260:Female; D006801:Humans; D007189:Indans / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D013997:Time Factors; D014055:Tomography, Emission-Computed
chemical_list: D007189:Indans; D010880:Piperidines; D000077265:Donepezil; D000110:Acetylcholinesterase