title: Systemic cidofovir in papillomatosis.
abstract: An 8-year-old patient with severe recurrent respiratory papillomatosis and pulmonary spread was treated by systemic administration of cidofovir in association with laser treatment for tracheal lesions. Complete disappearance of the lesions in the pharynx and larynx and a significant yet incomplete regression in the bronchi and lung parenchyma were observed without deleterious side effects. This is the first case report of systemic use of cidofovir to treat recurrent respiratory papillomatosis.
authors.affiliation: Otorhinolaryngology Department, Universitaire Ziekenhuizen Leuven, Leuven, Belgium. isabelle.vanvalckenborgh@med.kuleuven.ac.be
authors.forename: I
authors.initials: I
authors.lastname: Van Valckenborgh
authors.forename: W
authors.initials: W
authors.lastname: Wellens
authors.forename: K
authors.initials: K
authors.lastname: De Boeck
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: L
authors.initials: L
authors.lastname: Feenstra
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010212:Papilloma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D012142:Respiratory Tract Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir