title: Gastric scirrhous carcinoma as a rare cause of aggressive fibromatosis in the neck.
abstract: Aggressive fibromatosis is characterized by locally aggressive proliferation of fibroblasts and occasionally occurs in the head and neck. Although the etiology of this disease is still controversial, recent studies have shown that high levels of growth factors are found in these lesions. This article reports a case of 51-year-old woman with aggressive fibromatosis in the neck and inguinal region bilaterally. Gastric fiberscopic examination revealed a complication of advanced gastric scirrhous carcinoma. There were remarkably high levels of basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF) in the serum. Postmortem autopsy examination was performed and scattered gastric carcinoma cells were observed in the fibromatosis lesions. Immunohistological staining showed positive expression of bFGF in the fibromatoses and stomach. We concluded that this was a rare case in which bFGF and PDGF released from gastric carcinoma cells caused aggressive fibromatosis by promoting unregulated proliferation of fibroblasts and collagen production locally.
authors.affiliation: Department of Otolaryngology, Ehime University School of Medicine, Ehime, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hyodo
authors.forename: E
authors.initials: E
authors.lastname: Yumoto
authors.forename: H
authors.initials: H
authors.lastname: Wakisaka
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Takada
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000150:complications* / Q000175:diagnosis* / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D005336:Fiber Optic Technology / Q000379:methods; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D005347:Fibroblasts / Q000378:metabolism; D018222:Desmoid Tumors / Q000175:diagnosis / Q000209:etiology*; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000378:metabolism; D014057:Tomography, X-Ray Computed
chemical_list: D010982:Platelet-Derived Growth Factor; D016222:Fibroblast Growth Factor 2; D003094:Collagen