title: Approaches to vaccines for Psoroptes ovis (sheep scab).
abstract: A brief outline of the history of sheep scab in the UK is presented together with the current chemical methods used for its control and problems associated with these. Possible alternative approaches to control are discussed, as are selected aspects of the physiology of Psoroptes ovis and the pathogenesis of the scab lesion from the perspective of control through immunisation. Evidence is provided that immunity to the disease can indeed be acquired, both naturally after a previous infection and following inoculation of mite proteins in adjuvant. These results support the view that control by vaccination may be possible, although little is known to date about the antigens involved or the mechanism of protection.
authors.affiliation: Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Midlothian, Scotland, UK. smitd@mri.sari.ac.uk
authors.forename: W D
authors.initials: WD
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: van den Broek
authors.forename: J
authors.initials: J
authors.lastname: Huntley
authors.forename: D
authors.initials: D
authors.lastname: Pettit
authors.forename: J
authors.initials: J
authors.lastname: Machell
authors.forename: H R
authors.initials: HR
authors.lastname: Miller
authors.forename: P
authors.initials: P
authors.lastname: Bates
authors.forename: M
authors.initials: M
authors.lastname: Taylor
mesh_terms: D000821:Animal Feed; D000818:Animals; D004063:Digestion; D008924:Mite Infestations / Q000517:prevention & control / Q000662:veterinary*; D008925:Mites / Q000276:immunology; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*; D006113:United Kingdom; D014611:Vaccination / Q000662:veterinary*