Genome-wide RNAi.
In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematode Caenorhabditis elegans; most of the genes on C. elegans chromosome I and III have now been tested for RNAi phenotypes. The results validate RNAi as a powerful functional genomics tool for C. elegans, and point the way for similar large-scale studies in other species.
Barstead
R
R
Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. barsteadr@pcm41.ouhsc.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D020868:Gene Silencing; D016678:Genome; D012330:RNA, Double-Stranded / Q000235:genetics* / Q000494:pharmacology
D012330:RNA, Double-Stranded