[Metabolic calculation of the growth phase in rHSA fermentation].
The model equations of the growth phase of rHSA fermentation were derived on the base of both elemental balance and metabolic balance. The unknown parameters of the model were estimated by multivariable optimization. The model can preferably describe the relations between different macroscopic reaction rates of the process and provide the key for the high-density cultivation of Pichia pastoris.
Huang
M Z
MZ
State Key Laboratory of Bioreactor Engineering ECUST, Shanghai 200237.
Guo
M J
MJ
Chu
I
I
Hang
H F
HF
Zhuang
Y P
YP
Zhang
S L
SL
D005285:Fermentation; D010843:Pichia / Q000254:growth & development / Q000378:metabolism*; D011994:Recombinant Proteins / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*
D011994:Recombinant Proteins; D012709:Serum Albumin