title: High-throughput high-performance liquid chromatography/mass spectrometry for modern drug discovery.
abstract: High-throughput high-performance liquid chromatography/mass spectrometry can be used in the analysis of high-throughput organic synthesis products, bioanalytical target analysis for preclinical and clinical studies, and early absorption, distribution, metabolism and excretion (ADME) screening. New techniques are emerging, including system automation, faster analysis, programmed multiple extraction and analysis columns, multiple electrospray ionization channels, and automated 96-well sample preparation.
authors.affiliation: ArQule Inc., 19 Presidential Way, Wolburn, MA 01801, USA. Jkyranos@arqule.com
authors.forename: J N
authors.initials: JN
authors.lastname: Kyranos
authors.forename: H
authors.initials: H
authors.lastname: Cai
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.forename: W K
authors.initials: WK
authors.lastname: Goetzinger
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D013058:Mass Spectrometry; D010330:Patents as Topic; D013678:Technology, Pharmaceutical / Q000379:methods*