title: Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male factor indications for in vitro fertilization: a prospective randomized study.
abstract: OBJECTIVE
  To compare the fertilization rate and formation of good-quality embryos with conventional IVF and ICSI in patients with non-male factor infertility.
  
  
  METHODS
  Prospective controlled study.
  
  
  METHODS
  Infertility clinic.
  
  
  METHODS
  Thirty-five patients with non-male factor infertility.
  
  
  METHODS
  Retrieved sibling oocytes were randomly assigned to conventional IVF or ICSI. Of sibling oocytes assigned to ICSI, only metaphase II oocytes were injected with sperm.
  
  
  METHODS
  Fertilization rate and formation of good-quality embryos per retrieved oocyte.
  
  
  RESULTS
  Per retrieved oocyte, ICSI resulted in better fertilization rate compared with conventional IVF (71.3% [134 of 188] vs. 57.2% [107 of 187]). Per retrieved oocyte, ICSI also resulted in better formation of good-quality embryos at 48 hours after retrieval compared with conventional IVF (64.4% [121 of 188] vs. 47.1% [88 of 187]).
  
  
  CONCLUSIONS
  In IVF patients with non-male factor infertility, subjecting some sibling oocytes to ICSI increased the fertilization rate and formation of good-quality embryos per retrieved oocyte. It also avoided the problem of total fertilization failure in almost all cases.
authors.affiliation: Toronto Fertility Sterility Institute, 66 Avenue Road, Toronto, Ontario, Canada, M5R 3N8. tfsi@aaa-tfsi.cim
authors.forename: F
authors.initials: F
authors.lastname: Khamsi
authors.forename: Y
authors.initials: Y
authors.lastname: Yavas
authors.forename: S
authors.initials: S
authors.lastname: Roberge
authors.forename: J C
authors.initials: JC
authors.lastname: Wong
authors.forename: I C
authors.initials: IC
authors.lastname: Lacanna
authors.forename: M
authors.initials: M
authors.lastname: Endman
mesh_terms: D000328:Adult; D046508:Culture Techniques; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic