Latent intracellular Epstein-Barr Virus DNA demonstrated in ocular posttransplant lymphoproliferative disorder mimicking granulomatous uveitis with iris nodules in a child.
A case of intraocular posttransplant lymphoproliferative disorder (PTLD) is described in a 9-year-old female who underwent orthotopic liver transplantation at the age of 18 months. The prevalence of ophthalmic involvement in PTLD can be expected to rise with the increasing number of major organ transplantations, as well as improved survivorship. Children are particularly at risk for this posttransplant complication because they are usually seronegative for the Epstein-Barr virus (EBV) prior to transplant. Accurate diagnostic classification of PTLD to include confirmation of EBV infection carries significant therapeutic and prognostic implications.
O'hara
M
M
Department of Surgery, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Lloyd
W C
WC
Scribbick
F W
FW
Gulley
M L
ML
D002648:Child; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000532:radiotherapy / Q000821:virology; D015828:Eye Infections, Viral / Q000175:diagnosis* / Q000532:radiotherapy / Q000821:virology; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy; D006099:Granuloma / Q000175:diagnosis / Q000209:etiology; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007499:Iris Diseases / Q000175:diagnosis / Q000209:etiology; D016031:Liver Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000532:radiotherapy / Q000821:virology; D016559:Tacrolimus / Q000627:therapeutic use; D014605:Uveitis / Q000175:diagnosis / Q000209:etiology
D004279:DNA, Viral; D007166:Immunosuppressive Agents; D016559:Tacrolimus