Neurosyphilis presenting as schizophrenialike psychosis.
OBJECTIVE
The authors present a 30-year-old pregnant and previously healthy woman with sudden onset of agitation, delusions, and frontal lobe dementia. Serum and cerebrospinal fluid findings revealed the presence of untreated syphilis.


BACKGROUND
Neurosyphilis can present a variety of behavioral symptoms, including mania, depression, and psychosis.


METHODS
A neuropsychiatric and neurologic workup was performed before the start of antibiotic treatment. The status of the patient was observed throughout the course of her hospital stay for 7 months. Additionally, a neuropsychological evaluation was administered before treatment, and 2 weeks and 4 months after treatment.


RESULTS
After treatment of neurosyphilis, steady improvements were noted in psychotic and cognitive symptoms. By the end of 7 months, and after discontinuation of antipsychotic medication, no psychiatric symptoms were evident.


CONCLUSIONS
This case emphasizes the importance of considering neurosyphilis in the differential diagnosis of acute psychosis. Furthermore, this case shows the dramatic improvement in psychiatric symptoms and cognitive dysfunction in response to the treatment of neurosyphilis.
Kohler
C G
CG
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104-4283, USA.
Pickholtz
J
J
Ballas
C
C
D000208:Acute Disease; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006220:Haloperidol / Q000627:therapeutic use; D006801:Humans; D009494:Neurosyphilis / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010400:Penicillin G / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D012559:Schizophrenia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome
D006220:Haloperidol; D010400:Penicillin G