Effect of quinine on the morphology of mouse testes.
Single injection of quinine in a maximum tolerable dose to BALB/c mice caused morphological changes in the testes and suppressed spermatogenesis. Gonocytes in all layers of the spermatogenic epithelium, interstitial endocrinocytes, and sustenocytes proved to be sensitive to the toxic effect of the drug. The majority of detected morphological changes were reversible.
Borovskaya
T G
TG
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk.
Gol'dberg
E D
ED
Abramova
E V
EV
Fomina
T I
TI
Tkachenko
S B
SB
D000818:Animals; D007985:Leydig Cells / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009845:Oligospermia / Q000139:chemically induced; D011803:Quinine / Q000009:adverse effects*; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology* / Q000502:physiology
D011803:Quinine