title: JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta.
abstract: On the basis of significant sequence similarity, we have identified JmjC domains in more than 100 eukaryotic and bacterial sequences. These include human hairless, mutated in individuals with alopecia universalis, retinoblastoma-binding protein 2 and several putative chromatin-associated proteins. JmjC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling.
authors.affiliation: MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX, Oxford, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Clissold
authors.forename: C P
authors.initials: CP
authors.lastname: Ponting
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D019143:Evolution, Molecular; D054513:Group IV Phospholipases A2; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism; D010741:Phospholipases A / Q000737:chemistry* / Q000378:metabolism; D063151:Polycomb Repressive Complex 2; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D056485:Retinoblastoma-Binding Protein 2; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins
chemical_list: D002352:Carrier Proteins; D002843:Chromatin; C490267:HR protein, human; D047908:Intracellular Signaling Peptides and Proteins; C093650:Jarid2 protein, mouse; D009419:Nerve Tissue Proteins; D011506:Proteins; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D004247:DNA; C070050:KDM5A protein, human; D056485:Retinoblastoma-Binding Protein 2; D063151:Polycomb Repressive Complex 2; D010741:Phospholipases A; D054513:Group IV Phospholipases A2