In vitro screening of Indian medicinal plants for antiplasmodial activity.
Plants traditionally used in India to treat fever or malaria were examined in vitro for antiplasmodial properties against Plasmodium falciparum. Of 80 analysed ethanol extracts, from 47 species, significant effects were found for 31 of the extracts. These represent 23 different species from 20 families. Of the active species 20 were tested against P. falciparum for the first time. The following five species seems to be of special interest for further antimalarial studies, Casearia elliptica, Holarrhena pubescens, Pongamia pinnata, Soymida febrifuga, and Plumbago zeylanica.
Simonsen
H T
HT
Department of Medicinal Chemistry, Royal Danish School of Pharmacy, Group of Pharmacognosy, Universitetsparken 2, 2100 Copenhagen, Denmark.
Nordskjold
J B
JB
Smitt
U W
UW
Nyman
U
U
Palpu
P
P
Joshi
P
P
Varughese
G
G
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D007194:India; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development
D000962:Antimalarials; D010936:Plant Extracts; D002738:Chloroquine