title: Clinical trials in HIV-associated cognitive impairment: cognitive and functional outcomes.
abstract: Cognitive and functional outcomes are of primary interest in the design of efficacy trials in HIV-associated cognitive impairment. In a longitudinal cohort study, weak associations were found between measures of cognitive performance and commonly used measures of daily functioning (mostly self-report measures) in HIV-infected individuals. Modifications of current functional scales or new functional instruments are needed to assess the clinical relevance of cognitive changes in clinical trials of HIV-associated cognitive impairment.
authors.affiliation: Department of Neurology, University of Rochester, NY, USA.
authors.forename: G
authors.initials: G
authors.lastname: Schifitto
authors.forename: K
authors.initials: K
authors.lastname: Kieburtz
authors.forename: M P
authors.initials: MP
authors.lastname: McDermott
authors.forename: J
authors.initials: J
authors.lastname: McArthur
authors.forename: K
authors.initials: K
authors.lastname: Marder
authors.forename: N
authors.initials: N
authors.lastname: Sacktor
authors.forename: D
authors.initials: D
authors.lastname: Palumbo
authors.forename: O
authors.initials: O
authors.lastname: Selnes
authors.forename: Y
authors.initials: Y
authors.lastname: Stern
authors.forename: L
authors.initials: L
authors.lastname: Epstein
authors.forename: S
authors.initials: S
authors.lastname: Albert
mesh_terms: D015526:AIDS Dementia Complex / Q000503:physiopathology* / Q000523:psychology*; D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests