[Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma].
In order to research the relation between metalloproteinase (MMP) and tissue inhibitor of metalloproteinase (TIMP) and metastasis of salivary adenoid cystic carcinoma (ACC). We use dot blotting to analyse the expression of MMP-2, MMP-9 and TIMP-2 in ACC-2, a cell line of ACC in palate and ACC-M, a high lung metastasis clone which cloned from ACC-2. The result showed the expression of MMP-2 and MMP-9 were higher in ACC-M than that in ACC-2, but the expression of TIMP-2 were higher in ACC-2 than that in ACC-M This suggest MMP-2 and MMP-9 can promote ACC metastasis, TIMP-2 can suppress ACC metastasis. MMP and TIMP maybe a key mechanism of ACC metastasis.
Shi
H
H
School of Stomatology, Shanghai Second Medical University, Shanghai 200011.
He
R
R
Zhou
X
X
D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis* / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000096:biosynthesis* / Q000235:genetics; D014407:Tumor Cells, Cultured / Q000378:metabolism
D012333:RNA, Messenger; D019716:Tissue Inhibitor of Metalloproteinase-2; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9