title: Evidence of human papilloma virus infection but lack of Epstein-Barr virus in lymphoepithelioma-like carcinoma of uterine cervix: report of two cases and review of the literature.
abstract: Lymphoepithelioma-like carcinoma (LELC) of uterine cervix is an uncommon variant of squamous cell carcinoma (SCC). We report here 2 new cases in which DNA sequences from human papilloma virus (HPV) types 16 and 18 were detected by polymerase chain reaction (PCR). To the best of our knowledge, HPV infection has not been previously described in similar cases occuring in European women. Moreover, Epstein-Barr virus (EBV), which is frequently associated with cervical LELC in Asian women, was absent in our 2 cases. These results suggest that HPVs but not EBV can play a role in the pathogenesis of LELC occuring in women originating from Western countries.
authors.affiliation: Department of Pathology, Erasme University Hospital, CHU Saint-Pierre/Institut Bordet, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Noel
authors.forename: L
authors.initials: L
authors.lastname: Lespagnard
authors.forename: I
authors.initials: I
authors.lastname: Fayt
authors.forename: A
authors.initials: A
authors.lastname: Verhest
authors.forename: J
authors.initials: J
authors.lastname: Dargent
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology
chemical_list: D004279:DNA, Viral