Non-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors.
The essential steps of the novel non-mevalonate pathway of isopentenyl diphosphate and isoprenoid biosynthesis in plants are described. The first five enzymes and genes of this 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway are known. The herbicide fosmidomycin specifically blocks the second enzyme, the DOXP reductoisomerase. The DOXP/MEP pathway is also present in several pathogenic bacteria and the malaria parasite. Hence, all herbicides and inhibitors blocking this novel isoprenoid pathway in plants are also potential drugs against malaria and diseases caused by pathogenic bacteria.
Lichtenthaler
H K
HK
Botanical Institute II, University of Karlsruhe, Kaiserstr. 12, D-76128 Karlsruhe, Germany. hartmut.lichtenthaler@bio-geo.uni.karlsruhe.de
D019747:Aldose-Ketose Isomerases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D004896:Erythritol / Q000031:analogs & derivatives / Q000378:metabolism*; D006540:Herbicides / Q000494:pharmacology; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010428:Pentosephosphates / Q000378:metabolism*; D010944:Plants / Q000201:enzymology* / Q000235:genetics*; D010961:Plasmodium / Q000201:enzymology; D013403:Sugar Phosphates / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism*
C109460:1-deoxylulose 5-phosphate; C114232:2-C-methylerythritol 4-phosphate; D006540:Herbicides; D009097:Multienzyme Complexes; D010428:Pentosephosphates; D013403:Sugar Phosphates; D013729:Terpenes; D010088:Oxidoreductases; C114231:1-deoxy-D-xylulose 5-phosphate reductoisomerase; D019747:Aldose-Ketose Isomerases; D004896:Erythritol