Oxidative degradation of pharmaceuticals: theory, mechanisms and inhibition.
Oxidation is a common pathway for drug degradation in liquid and solid formulations. The present article reviews mechanistic details of autoxidation and chain oxidation processes, as well as the oxidation of selected functional groups commonly affected in drugs.
Hovorka
S
S
Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA.
Schöneich
C
C
D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D017382:Reactive Oxygen Species
D004364:Pharmaceutical Preparations; D017382:Reactive Oxygen Species