title: Catecholamines and their metabolites in the brain and urine of rats with experimental Parkinson's disease.
abstract: The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopamine, dioxyphenilalanine, and DOPAC by more than 90%. A positive correlation was found between the concentrations of these metabolites in the urine and striatum. Measurement of urinary catecholamines and their metabolites is a perspective test for evaluating the status of the dopaminergic nigrosostriate system of the brain in experimental parkinsonism.
authors.affiliation: V. P. Serbskii State Center of Social and Forensic Psychiatry, Moscow.
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhonin
authors.forename: V P
authors.initials: VP
authors.lastname: Baklaushev
authors.forename: B M
authors.initials: BM
authors.lastname: Kogan
authors.forename: E A
authors.initials: EA
authors.lastname: Savchenko
authors.forename: S V
authors.initials: SV
authors.lastname: Lebedev
authors.forename: I V
authors.initials: IV
authors.lastname: Man'kovskaya
authors.forename: T S
authors.initials: TS
authors.lastname: Filatova
authors.forename: I U
authors.initials: IU
authors.lastname: Yusupova
authors.forename: T B
authors.initials: TB
authors.lastname: Dmitrieva
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism / Q000652:urine; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D002395:Catecholamines / Q000378:metabolism* / Q000652:urine; D004295:Dihydroxyphenylalanine / Q000378:metabolism / Q000652:urine; D004298:Dopamine / Q000378:metabolism / Q000652:urine; D004837:Epinephrine / Q000378:metabolism / Q000652:urine; D006719:Homovanillic Acid / Q000378:metabolism / Q000652:urine; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D009638:Norepinephrine / Q000378:metabolism / Q000652:urine; D016627:Oxidopamine / Q000633:toxicity; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology / Q000652:urine; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002395:Catecholamines; D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D004295:Dihydroxyphenylalanine; D016627:Oxidopamine; C010117:3,4-dihydroxyphenylglycol; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine