In vitro development of resistance to six quinolones in Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus.
Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus isolates were exposed to subinhibitory MICs of ciprofloxacin, sparfloxacin, gatifloxacin, moxifloxacin, clinafloxacin, and gemifloxacin during a 10-day period. Subculturing led to resistance development, regardless of the initial potencies of the quinolones. None of the quinolones was associated with a significantly slower rate of resistance development.
Boos
M
M
Institute for Medical Microbiology and Virology, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.
Mayer
S
S
Fischer
A
A
Köhrer
K
K
Scheuring
S
S
Heisig
P
P
Verhoef
J
J
Fluit
A C
AC
Schmitz
F J
FJ
D000890:Anti-Infective Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000502:physiology; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013297:Streptococcus pyogenes / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones