Clinical and experimental study of antiarrhythmic and antianginal effects of quaternidine.
High antiarrhythmic activity of a new Russian antiarrhythmic drug quaternidine in ventricular arrhythmia was studied in 96 coronary patients by Holter monitoring, bicycle ergometry, and echocardiography. The drug had a positive impact on local kinetics in left-ventricular ischemic myocardium and some parameters of bicycle exercise test. The preparation possesses no arrhythmogenic effect. Experiments on 30 random-bred rats showed that the drug reduced the necrotic zone under conditions of experimental coronary occlusion. Experiments on 14 intact cats demonstrated that quaternidine had no effect on coronary bloodflow.
Kostin
Y V
YV
Department of Pharmacology, Mordovian University, Saransk, Russia.
Sernov
L N
LN
Moiseeva
I Y
IY
Kulikova
N N
NN
Shmyreva
M V
MV
Klimovich
Y G
YG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000188:drug therapy*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology; D051381:Rats; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy / Q000503:physiopathology; D018879:Ventricular Premature Complexes / Q000188:drug therapy / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents