Cure of undifferentiated small cell carcinoma of the urinary bladder with M-VAC chemotherapy.
Small cell carcinoma (SCC) of the urinary bladder is a rare, aggressive malignancy with approximately 135 cases reported in the literature. Treatments have included chemotherapy, radical surgery, radiotherapy, and combinations of these. We present the apparent cure of a 73-year-old man who presented with clinical stage T2 SCC of the urinary bladder. He was treated with three cycles of methotrexate, vinblastine, Adriamycin (doxorubicin), and cisplatin (M-VAC) chemotherapy. Subsequent radical cystoprostatectomy revealed no pathologic evidence of tumor. The patient is alive and well with no evidence of recurrence 3 years post cystectomy. A brief review of the literature is also presented.
Nejat
R J.
RJ
Squier Urological Clinic, College of Physicians and Surgeons, Columbia University, 10032, New York, NY, USA
Purohit
R
R
Goluboff
E T.
ET
Petrylak
D
D
Rubin
M A.
MA
Benson
M C.
MC