title: Fibrinogen response with simvastatin versus atorvastatin in familial hypercholesterolemia.
abstract: The clinical and biochemical determinants of the fibrinogen response to simvastatin or atorvastatin therapy were assessed in 130 patients with severe polygenic or familial hypercholesterolemia treated in a randomized open-trial format design. Hyperfibrinogenemia was associated with atorvastatin, baseline fibrinogen, and initial concentration and change in concentration of apolipoprotein B or low-density lipoprotein cholesterol.
authors.affiliation: Department of Chemical Pathology, King's College London, Guy's, King's & St. Thomas' Medical School,  United Kingdom. Wierzbicki@kcl.ac.uk
authors.forename: A S
authors.initials: AS
authors.lastname: Wierzbicki
authors.forename: P J
authors.initials: PJ
authors.lastname: Lumb
authors.forename: G
authors.initials: G
authors.lastname: Chik
authors.forename: M A
authors.initials: MA
authors.lastname: Crook
mesh_terms: D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000069059:Atorvastatin; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy / Q000235:genetics; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006538:Heptanoic Acids / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000008:administration & dosage* / Q000009:adverse effects; D012307:Risk Factors; D019821:Simvastatin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D011758:Pyrroles; D005340:Fibrinogen; D000069059:Atorvastatin; D019821:Simvastatin