title: Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain.
abstract: Chronic hypertension during aging is a serious threat to the cerebral vasculature. The larger brain arteries can react to hypertension with an abnormal wall thickening, a loss of elasticity and a narrowed lumen. However, little is known about the hypertension-induced alterations of cerebral capillaries. The present study describes ultrastructural alterations of the cerebrocortical capillary wall, such as thickening and collagen accumulation in the basement membrane of aging spontaneously hypertensive stroke-prone rats. The ratio of cortical capillaries with such vascular pathology occurred significantly more frequently in hypertensive animals. Nimodipine and nifedipine are potential drugs to decrease blood pressure in hypertension but their beneficial effects in experimental studies reach beyond the control of blood pressure. Nimodipine and nifedipine can alleviate ischemia-related symptoms and improve cognition. These drugs differ in that nifedipine, but not nimodipine reduces blood pressure at the here-used concentration while both drugs can penetrate the blood-brain barrier. Here we show that chronic treatment of aging hypertensive stroke-prone rats with nimodipine or nifedipine could preserve microvascular integrity in the cerebral cortex.
authors.affiliation: Department of Animal Physiology, Graduate School of Behavioral and Cognitive Neurosciences, University of Groningen, P.O.B. 14, 9750 AA, Haren, The Netherlands. E.FARKAS@biol.rug.nl
authors.forename: E
authors.initials: E
authors.lastname: Farkas
authors.forename: G I
authors.initials: GI
authors.lastname: De Jong
authors.forename: E
authors.initials: E
authors.lastname: Apró
authors.forename: J I
authors.initials: JI
authors.lastname: Keuker
authors.forename: P G
authors.initials: PG
authors.lastname: Luiten
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D001522:Behavior, Animal; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D002196:Capillaries / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004326:Drinking; D004435:Eating; D005106:Exploratory Behavior; D006973:Hypertension / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009543:Nifedipine / Q000494:pharmacology; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D020521:Stroke / Q000188:drug therapy / Q000473:pathology
chemical_list: D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D009553:Nimodipine; D009543:Nifedipine