Evidence for an alteration of plasma and liver proteins response to dexamethasone in aging rats.
The aim of this study was carried out to analyse the liver and plasma proteins response to dexamethasone in adult (6-8 months) and old (24 months) rats in order to ascertain the involvement of glucocorticoids in the aging process. The animals received dexamethasone (Dex) for 5 or 6 days. As Dex decreased food intake, all groups were pair fed to dexamethasone-treated old rats. The synthesis of mixed plasma and liver proteins (assessed by a flooding dose of [13C] valine) was similarly greatly improved in adult and old rats after Dex treatment. However, the level of mixed plasma proteins was only slightly increased. When specific plasma proteins were assessed, a similar increase in the concentration of albumin and alpha1 acid glycoprotein was observed in adult and old rats. By contrast, fibrinogen decreased to a greater extend in old rats and alpha2 macroglobulin became undetectable in old animals. It was concluded that the response of plasma and liver proteins to Dex was altered in old rats and may contribute to the pathogenesis of several diseases which occur during aging.
Savary
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Unité de Recherche sur les Herbivores, Equipe Nutriments et Métabolismes, Institut National de la Recherche Agronomique, Centre de Recherches de Clermont-Ferrand Theix, 63122, St Genès Champanelle, France. Savary@clermont.inra.fr
Debras
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E
Dardevet
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Rambourdin
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Vasson
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MP
Obled
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Grizard
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J
D000375:Aging / Q000097:blood* / Q000187:drug effects / Q000378:metabolism; D000418:Albumins / Q000378:metabolism; D000818:Animals; D015415:Biomarkers; D003907:Dexamethasone / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism; D005938:Glucocorticoids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009961:Orosomucoid / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000511:alpha-Macroglobulins / Q000378:metabolism
D000418:Albumins; D015415:Biomarkers; D005938:Glucocorticoids; D009961:Orosomucoid; D011506:Proteins; D000511:alpha-Macroglobulins; D003907:Dexamethasone; D005340:Fibrinogen