Lead reduces the nephrotoxicity of mercuric chloride.
The nephrotoxic effect of a single intraperitoneal dose of mercuric chloride (HgCl(2); 6 mg/kg) on adult CD-1 female mice was reduced at 24 and 48 h after injection, by a 48-h pretreatment nontoxic dose of lead acetate (Pb; 5 mg/kg) delivered by intravenous tail-vein injection (intravenous). While protection is temporally associated with lead-induced mitosis, occurring about 39 h after intracardiac lead injection (D. D Choie and G. W. Richter, 1974, Lab. Invest. 30, 447-451), the mechanism of the observed protection remains to be established.
Ewald
K A
KA
KERA Environmental, LLC, Worthington, Massachusetts 01098, USA.
Calabrese
E J
EJ
D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D007854:Lead / Q000494:pharmacology*; D008627:Mercuric Chloride / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D051379:Mice; D008938:Mitosis / Q000187:drug effects
D007854:Lead; D008627:Mercuric Chloride