title: Low-density lipoprotein apheresis in the treatment of atherosclerosis and other potential uses.
abstract: This review concerns the clinical impact of low-density lipoprotein (LDL) apheresis for patients with refractory hypercholesterolemia. We examine and provide examples of investigations that have demonstrated the clinical benefits of LDL apheresis. In addition to benefits derived from the stabilization or regression of arterial lesions, we highlight other possible mechanisms related to clinical improvement. We also discuss the potential advantages of lipid apheresis for the treatment of patient populations other than those characterized by severe hypercholesterolemia and premature coronary heart disease.
authors.affiliation: Lipid, Atherosclerosis, and Metabolic Clinic, University of Kansas Medical Center, 1336 KU Hospital, 3901 Rainbow Boulevard, Kansas City, KS 66160-7374, USA. pmoriart@kumc.edu
authors.forename: P M
authors.initials: PM
authors.lastname: Moriarty
authors.forename: C A
authors.initials: CA
authors.lastname: Gibson
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000209:etiology* / Q000628:therapy*; D003928:Diabetic Nephropathies / Q000628:therapy; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D003639:Hearing Loss, Sudden / Q000628:therapy; D016027:Heart Transplantation; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications* / Q000175:diagnosis; D008077:Lipoproteins, LDL; D008297:Male; D010316:Particle Size; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D008077:Lipoproteins, LDL