Mitotic checkpoints: from yeast to cancer.
Separation of chromosomes during mitosis is monitored by a checkpoint that leads to cell-cycle arrest if the chromosomes are not properly attached to the mitotic spindle. Molecular mechanisms controlling this checkpoint have been identified. In addition, loss of this checkpoint has been shown to result in chromosome missegregation in higher eukaryotes and may contribute to the genomic instability observed in human cancers.
Wassmann
K
K
Cell Biology Program, Memorial Sloan-Kettering Cancer Center and the Sloan-Kettering Division, Graduate School of Medical Sciences, Cornell University, Box 241, 1275 York Avenue, New York, New York 10021, USA.
Benezra
R
R
D025601:Adenomatous Polyposis Coli Protein; D000705:Anaphase / Q000235:genetics; D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism; D018816:Genes, cdc; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D008677:Metaphase / Q000235:genetics; D008938:Mitosis / Q000235:genetics*; D009369:Neoplasms / Q000473:pathology*; D008941:Spindle Apparatus / Q000378:metabolism; D015003:Yeasts / Q000166:cytology*
D025601:Adenomatous Polyposis Coli Protein; D003598:Cytoskeletal Proteins