Cilostazol suppresses intimal formation in dog grafted veins with reduction of angiotensin II-forming enzymes.
Cilostazol prevents neointimal formation, but its mechanism has remained unclear. We investigated whether intimal formation in dog grafted veins is suppressed by cilostazol, and studied the effect of cilostazol on angiotensin II-forming enzymes. The external jugular vein was grafted to the carotid artery, and cilostazol (60 mg/kg/day) was administered orally. By 28 days after the surgery, the intimal cross-sectional area of the grafted vein was reduced to 16.7% by treatment of cilostazol, and the activities of angiotensin II-forming enzymes were suppressed significantly. The inhibitory effect of cilostazol in intimal formation may be dependent on inhibition of angiotensin II-forming enzymes.
Takai
S
S
Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka 569-8686, Japan. pha010@art.osaka-med.ac.jp
Jin
D
D
Nishimoto
M
M
Sakaguchi
M
M
Kirimura
K
K
Yuda
A
A
Miyazaki
M
M
D000804:Angiotensin II / Q000096:biosynthesis*; D000818:Animals; D001808:Blood Vessels / Q000201:enzymology / Q000378:metabolism* / Q000637:transplantation; D053818:Chymases; D000077407:Cilostazol; D004285:Dogs; D066298:In Vitro Techniques; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects; D012697:Serine Endopeptidases / Q000378:metabolism; D013777:Tetrazoles / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D013777:Tetrazoles; D014665:Vasodilator Agents; D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D012697:Serine Endopeptidases; D053818:Chymases; D000077407:Cilostazol