Can cerebral blood volume be measured reproducibly with an improved near infrared spectroscopy system?
In some circumstances, cerebral blood volume (CBV) can be used as a measure for cerebral blood flow. A new near infrared spectroscope was used for determining the reproducibility of CBV measurements assessed by the O2-method. Twenty-seven healthy subjects were investigated. An intrasubject coefficient of variation (CV) was calculated, based on four identical episodes of desaturation-resaturation (O2-method) procedures for CBV measurements. Two trials were performed, with (trial 1) and without (trial 2) disconnecting the equipment. A mean CV of 12.6% and 10.0% was found in trial 1 and 2, respectively. Cerebral blood volume values yield 3.60+/-0.82 mL 100 g(-1). Cerebral blood volume could be measured reproducible in adults using near infrared spectroscopy, if the arterial desaturation is limited to approximately 5% from baseline level.
Van de Ven
M J
MJ
Department of Pulmonology Dekkerswald, University of Nijmegen, Groesbeek, The Netherlands.
Colier
W N
WN
van der Sluijs
M C
MC
Walraven
D
D
Oeseburg
B
B
Folgering
H
H
D000328:Adult; D001810:Blood Volume; D001921:Brain / Q000098:blood supply*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000032:analysis; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin