Ileus after administration of cold remedy in an elderly diabetic patient treated with acarbose.
A 69-year-old type 2 diabetic man was admitted due to diabetic gangrane. He had a history of subtotal gastrectomy. During hospitalization, he was treated with regular insulin and 300 mg/day of acarbose. He developed a low grade fever, cough and nasal discharge, and was given a compound "cold" remedy with anticholenergic properties. The next day, he suffered from a paralytic ileus. Oral intake and acarbose were withheld and the ileus spontaneously resolved after 2 days. These finding indicate the possibility that the ileus was triggered by drugs with anticholinergic properties in this elderly diabetic patient treated with alpha-glucosidase inhibitors.
Oba
K
K
The Division of Geriatric Medicine, Nippon Medical School, Tokyo, Japan.
Kudo
R
R
Yano
M
M
Watanabe
K
K
Ajiro
Y
Y
Okazaki
K
K
Suzuki
T
T
Nakano
H
H
Metori
S
S
D020909:Acarbose / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D003139:Common Cold / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007415:Intestinal Obstruction / Q000139:chemically induced*; D008297:Male
D018680:Cholinergic Antagonists; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D020909:Acarbose