title: Two cases of right ventricular ischemic injury due to massive pulmonary embolism.
abstract: In general, massive pulmonary embolism induces severe right ventricular overload, but pathological changes in the right ventricle due to pulmonary embolism is rarely seen. In this report, we describe two autopsy cases of massive pulmonary embolism without pre-existing cardiopulmonary disease. Both cases were accompanied by myocarditis-like changes in the right ventricle and infiltration of a number of polymorphonuclear neutrophils and mononuclear cells into the dilated right ventricular wall. Transmural or subendocardial coagulation necrosis was not apparent. Almost all of the mononuclear cells were immunohistochemically revealed to be CD68-positive macrophages. We speculated that these findings resulted from ischemia due to massive pulmonary embolism.
authors.affiliation: Department of Legal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, 113-8519, Tokyo, Japan. iwadate.legm@med.tmd.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Iwadate
authors.forename: K
authors.initials: K
authors.lastname: Tanno
authors.forename: M
authors.initials: M
authors.lastname: Doi
authors.forename: T
authors.initials: T
authors.lastname: Takatori
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
mesh_terms: D000063:Accidents, Traffic; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D001344:Autopsy; D002423:Cause of Death; D005260:Female; D006801:Humans; D007869:Leg Injuries / Q000150:complications; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D017202:Myocardial Ischemia / Q000209:etiology* / Q000473:pathology*; D009205:Myocarditis / Q000209:etiology* / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology; D011655:Pulmonary Embolism / Q000150:complications*; D018497:Ventricular Dysfunction, Right / Q000209:etiology* / Q000473:pathology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule