Human placental NAD(P)H oxidase: solubilization and properties.
The NAD(P)H oxidase in the syncytiotrophoblast of the term human placenta, which had previously been identified only by cytochemical methods, has been solubilized and a number of its biochemical properties have been defined. It is a protein composed of a 58 kDa and a 33 kDa subunit, with properties that clearly distinguish it from the respiratory burst oxidase of transient neutrophils and macrophages. The enzyme activity is constitutive in the trophoblast and is a source of reactive oxygen species (ROS) at the fetal-maternal interface.
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Department of Biology, University of San Diego, 5998 Alcala Park, San Diego, CA 92110-2492, USA.
D000328:Adult; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D009247:NADH, NADPH Oxidoreductases / Q000302:isolation & purification / Q000378:metabolism*; D019255:NADPH Oxidases; D011247:Pregnancy; D014327:Trophoblasts / Q000201:enzymology*
D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases