Different wheat germ agglutinin-horseradish peroxidase labeling in structures related to the development of amygdaline kindling in the rat.
The anterior commissure, medial and lateral bed nuclei of the stria terminalis and both sides of the medial prefrontal cortex showed a progressive increasing of wheat germ agglutinin-horseradish peroxidase labeling (WGA-HRP) in successive stages of amygdaline kindling, after 48 h of a right amygdala WGA-HRP injection. In contrast, during the first stages the number of labeled cells in the contralateral amygdala was reduced, reaching control values after the first generalized seizure. The present paper indicates that these structures are involved in the propagation and generalization of the epileptic activity. Our findings show that both sides of the medial prefrontal cortex can be activated before the contralateral amygdaloid complex, during the development of the amygdaline electrical kindling in the rat.
Condés-Lara
M
M
Departamento de Neurofisilogíaa, Centro de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM-Juriquilla, Apartado Postal 1-1141, Querétaro, 76001, Qro. Mexico. condes@servidor.unam.mx
Talavera-Cuevas
E
E
Larriva-Sahd
J
J
Martínez-Lorenzana
G
G
D000679:Amygdala / Q000473:pathology* / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D007696:Kindling, Neurologic / Q000473:pathology* / Q000502:physiology; D008297:Male; D015335:Molecular Probes / Q000494:pharmacology; D009434:Neural Pathways / Q000473:pathology* / Q000503:physiopathology; D009474:Neurons / Q000473:pathology; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012686:Septal Nuclei / Q000473:pathology / Q000503:physiopathology; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate / Q000494:pharmacology
D015335:Molecular Probes; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate