title: Origin of the mutations in the parkin gene in Europe: exon rearrangements are independent recurrent events, whereas point mutations may result from Founder effects.
abstract: A wide variety of mutations in the parkin gene, including exon deletions and duplications, as well as point mutations, result in autosomal recessive early-onset parkinsonism. Interestingly, several of these anomalies were found repeatedly in unrelated patients and may therefore result from recurrent, de novo mutational events or from founder effects. In the present study, haplotype analysis, using 10 microsatellite markers covering a 4.7-cM region known to contain the parkin gene, was performed in 48 families, mostly from European countries, with early-onset autosomal recessive parkinsonism. The patients carried 14 distinct mutations in the parkin gene, and each mutation was detected in more than one family. Our results support the hypothesis that exon rearrangements occurred independently, whereas some point mutations, found in families from different geographic origins, may have been transmitted by a common founder.
authors.affiliation: INSERM U289, Hôpital de la Salpêtrière, 75651 Paris, Cedex 13, France.
authors.forename: M
authors.initials: M
authors.lastname: Periquet
authors.forename: C
authors.initials: C
authors.lastname: Lücking
authors.forename: J
authors.initials: J
authors.lastname: Vaughan
authors.forename: V
authors.initials: V
authors.lastname: Bonifati
authors.forename: A
authors.initials: A
authors.lastname: Dürr
authors.forename: G
authors.initials: G
authors.lastname: De Michele
authors.forename: M
authors.initials: M
authors.lastname: Horstink
authors.forename: M
authors.initials: M
authors.lastname: Farrer
authors.forename: S N
authors.initials: SN
authors.lastname: Illarioshkin
authors.forename: P
authors.initials: P
authors.lastname: Pollak
authors.forename: M
authors.initials: M
authors.lastname: Borg
authors.forename: C
authors.initials: C
authors.lastname: Brefel-Courbon
authors.forename: P
authors.initials: P
authors.lastname: Denefle
authors.forename: G
authors.initials: G
authors.lastname: Meco
authors.forename: T
authors.initials: T
authors.lastname: Gasser
authors.forename: M M
authors.initials: MM
authors.lastname: Breteler
authors.forename: N
authors.initials: N
authors.lastname: Wood
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
authors.forename: A
authors.initials: A
authors.lastname: Brice
mesh_terms: D017668:Age of Onset; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6; D005060:Europe; D005091:Exons; D005190:Family; D018703:Founder Effect; D015321:Gene Rearrangement; D005808:Genes, Recessive; D005819:Genetic Markers; D006801:Humans; D008025:Ligases / Q000235:genetics*; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats / Q000235:genetics; D009154:Mutation; D009679:Nuclear Family; D010300:Parkinson Disease / Q000235:genetics*; D020734:Parkinsonian Disorders / Q000235:genetics*; D017354:Point Mutation; D017384:Sequence Deletion; D044767:Ubiquitin-Protein Ligases; D044465:White People / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D044767:Ubiquitin-Protein Ligases; D008025:Ligases