title: Cell-transistor hybrid systems and their potential applications.
abstract: Electrogenic cells fire spontaneous or triggered action potentials (transient changes of their membrane potentials) and can be electronically coupled to external electrodes (arrays). Signals from rat heart-muscle cells were recorded by a field-effect transistor and the results described on the basis of an equivalent circuit. This technique has potential applications in drug screening, such as measuring the dose-response curve of isoproterenol, a beta-adrenergic agonist with a positive chronotropic effect.
authors.affiliation: Max-Planck-Institute for Polymer Research, Ackermannweg 10, D-55128, Mainz, Germany. offenhaeusser@mpip-mainz.mpg.de
authors.forename: A
authors.initials: A
authors.lastname: Offenhäusser
authors.forename: W
authors.initials: W
authors.lastname: Knoll
mesh_terms: D000200:Action Potentials; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D004566:Electrodes; D006321:Heart / Q000187:drug effects / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology; D051381:Rats; D012666:Semiconductors
chemical_list: D000318:Adrenergic beta-Agonists; D007545:Isoproterenol