title: Fenvalerate treatment affects development of olfactory glomeruli in Manduca sexta.
abstract: Low doses of fenvalerate, a widely used type-II pyrethroid insecticide, have been shown previously to produce abnormal olfactory centers in the brain and abnormal olfactory-mediated behavior in beetles (Wegerhoff et al. [1998] Neuroreport 9:3241-3245). Here, we use the experimental advantages of the moth Manduca sexta to explore the cellular changes that lead to these abnormalities. Our results indicate that treatment with fenvalerate may affect multiple aspects of the development of the primary olfactory centers, the antennal lobes, in Manduca, including ingrowth of olfactory receptor axons, axon fasciculation, and targeting within the antennal lobe, and intercellular signaling between the receptor axons and the glial cells that ordinarily surround and stabilize the developing olfactory glomeruli.
authors.affiliation: Institute of Biochemistry, University of Kiel, D-24098 Kiel, Germany. rwegerhoff@netscape.net
authors.forename: R
authors.initials: R
authors.lastname: Wegerhoff
authors.forename: W
authors.initials: W
authors.lastname: Rössler
authors.forename: M
authors.initials: M
authors.lastname: Higgins
authors.forename: L A
authors.initials: LA
authors.lastname: Oland
authors.forename: L P
authors.initials: LP
authors.lastname: Tolbert
mesh_terms: D000818:Animals; D000906:Antibodies; D005260:Female; D017952:Ganglia, Invertebrate / Q000737:chemistry / Q000187:drug effects / Q000254:growth & development; D019476:Insect Proteins / Q000032:analysis / Q000276:immunology; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D018402:Manduca / Q000187:drug effects*; D008675:Metamorphosis, Biological / Q000187:drug effects; D009570:Nitriles; D018034:Olfactory Receptor Neurons / Q000737:chemistry / Q000187:drug effects* / Q000254:growth & development; D010675:Pheromones / Q000502:physiology; D011722:Pyrethrins / Q000494:pharmacology*; D015320:Tachykinins / Q000032:analysis / Q000276:immunology
chemical_list: D000906:Antibodies; D019476:Insect Proteins; D007306:Insecticides; D009570:Nitriles; D010675:Pheromones; D011722:Pyrethrins; D015320:Tachykinins; C063414:locustatachykinin II protein, Locusta migratoria; C017690:fenvalerate