Experimental Study on the Carcinogenicity of the Cytostatic Drug Ftorafur (Tegafur).
Long-term carcinogenicity of Ftorafur (Tegafur) was studied in rodents. Rats and mice were treated for one year per os with 40 (mice) and 60 (rat) mg/kg Ftorafur twice a week and were followed for their entire life. Analysis of the data provide no evidence for the carcinogenicity of Ftorafur in rodents. These findings are similar to other antimetabolite studies and contrasts with the carcinogenic alkylating agents.
Griciuté
Laima
L
Lithuanian Oncological Center, Vilnius, Lithuania.
Domkiené
Vida