title: Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis.
abstract: Nkx-2.1 is a member of the vertebrate Nkx family of homeobox genes; it was originally identified as a tissue-specific regulator of thyroglobulin and thyroperoxidase gene transcription. Here we report on the embryonic expression of Xnkx-2.1, which is expressed in the presumptive forebrain from early neurulation onwards. In tadpole stage embryos Xnkx-2.1 transcripts are primarily detected in ventral forebrain, lung buds and thyroid anlage. Therefore, Xnkx-2.1 may be part of the genetic network that controls the early development of these organs.
authors.affiliation: Georg-August-Universität Göttingen, Institute of Biochemistry and Molecular Cell Biology, Humboldtallee 23, 37073 Göttingen, Germany. thollem1@gwdg.de
authors.forename: T
authors.initials: T
authors.lastname: Hollemann
authors.forename: T
authors.initials: T
authors.lastname: Pieler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics*; D008168:Lung / Q000196:embryology*; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D016548:Prosencephalon / Q000196:embryology*; D017386:Sequence Homology, Amino Acid; D013961:Thyroid Gland / Q000201:enzymology*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology
chemical_list: D017931:DNA Primers; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D029867:Xenopus Proteins; C000614411:nkx2-1 protein, Xenopus