Regional distribution of methamphetamine in autopsied brain of chronic human methamphetamine users.
We measured levels of methamphetamine and those of its metabolite amphetamine in 15 autopsied brain regions of 14 human methamphetamine users. Only slight regional differences were observed in drug concentrations among the brain areas. Although, some redistribution of the drugs probably occurred postmortem, these data suggest that methamphetamine might not be preferentially retained in dopamine-rich brain areas but is heterogenously distributed in brain of chronic human users of the drug. The possible pharmacological actions of methamphetamine in both dopamine-rich and poor brain areas of chronic drug users need to be considered.
Kalasinsky
K S
KS
Office of the Armed Forces Medical Examiner, Division of Forensic Toxicology, Armed Forces institute of Pathology, Washington, DC, USA.
Bosy
T Z
TZ
Schmunk
G A
GA
Reiber
G
G
Anthony
R M
RM
Furukawa
Y
Y
Guttman
M
M
Kish
S J
SJ
D000328:Adult; D000661:Amphetamine / Q000032:analysis*; D019969:Amphetamine-Related Disorders / Q000378:metabolism* / Q000473:pathology*; D001344:Autopsy / Q000379:methods*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002423:Cause of Death; D002908:Chronic Disease; D005260:Female; D006197:Hair / Q000737:chemistry; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000032:analysis* / Q000378:metabolism* / Q000506:poisoning; D011180:Postmortem Changes; D014018:Tissue Distribution
D008694:Methamphetamine; D000661:Amphetamine