[The effect of tamoxifen on experimental nasal hypersensitivity].
The effect of estrogen on nasal hypersensitivity was observed in female adult guinea pigs with high level of estrogen. The animal were divided into three groups: group A as normal control; in group B, tamoxifen was given before inducing high level estrogen and in group C, estrogen was given but without tamoxifen. The groups B and C were sensitized and then challenge with TDI as described previously. The result showed that tamoxifen may inhibit significantly the development of nasal hypersensitivity and reduce the pathologic changes of nasal mucosa. It is suggested that the mast cells may be the target of estrogen and tamoxifen might be useful in treatment of nasal hyperreaction concerning with the change of estrogen level.
Dong
Z
Z
Department of Otorhinolaryngology & Head and Neck Surgery, 3rd Clinical College, Bethune University of Medical Sciences, Changchun, 130031.
Zhu
J
J
Sun
S
S
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D009297:Nasal Mucosa / Q000473:pathology; D009668:Nose Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D011897:Random Allocation; D011959:Receptors, Estradiol / Q000037:antagonists & inhibitors*; D013629:Tamoxifen / Q000627:therapeutic use*; D014051:Toluene 2,4-Diisocyanate
D011959:Receptors, Estradiol; D013629:Tamoxifen; D014051:Toluene 2,4-Diisocyanate