The best defense is a good offense--Salmonella deploys an ADP-ribosylating toxin.
The dramatic clinical manifestations of toxigenic infections such as cholera and diphtheria occur without substantial bacterial invasion. Disease is mediated by the secretion of potent toxins that use ADP-ribosylation as the catalytic mechanism underlying their action. ADP-ribosylating toxins comprise a large family, including the cholera, diphtheria, pertussis and Escherichia coli heat-labile (LT) toxins, and all produce disease by altering key metabolic processes after transfer of an ADP-ribose moiety from NAD to specific host-cell target proteins. A new paradigm implicating ADP-ribosylation during intracellular pathogenesis is beginning to emerge from recent research in Salmonella.
Lesnick
M L
ML
Department of Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0640, USA.
Guiney
D G
DG
D036002:ADP Ribose Transferases / Q000378:metabolism*; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001427:Bacterial Toxins / Q000378:metabolism*; D017124:Conserved Sequence; D004731:Endotoxins / Q000378:metabolism*; D004768:Enterotoxins / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D012475:Salmonella / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D037521:Virulence Factors
D001427:Bacterial Toxins; D004731:Endotoxins; D004768:Enterotoxins; D037521:Virulence Factors; C027952:salmonella toxin; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D036002:ADP Ribose Transferases; C415223:spvB protein, Salmonella enterica virulence plasmid