Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN.
Proper completion of mitosis requires careful coordination of numerous cellular events. It is crucial, for example, that cells do not initiate spindle disassembly and cytokinesis until chromosomes have been properly segregated. Cells have developed numerous safeguards or checkpoints to delay exit from mitosis and initiation of the next cell cycle in response to defects in late mitosis. In this review, we discuss recent work on two homologous signaling pathways in budding and fission yeast, termed the mitotic exit network (MEN) and septation initiation network (SIN), respectively, that are essential for coordinating completion of mitosis and cytokinesis with other mitotic events.
McCollum
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Dept of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA. dannel.mccollum@umassmed.edu
Gould
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KL
D001426:Bacterial Proteins / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D004249:DNA Damage / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D009363:Neoplasm Proteins; D010445:Peptide Elongation Factors; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000502:physiology*; D012568:Schizosaccharomyces / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D035602:Transcriptional Elongation Factors
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C090862:ELL protein, human; D009363:Neoplasm Proteins; D010445:Peptide Elongation Factors; D014157:Transcription Factors; D035602:Transcriptional Elongation Factors; C076733:FlaD protein, Bacteria