Time sequence and types of memory deficits after experimental status epilepticus.
P35 rats subjected to kainate induced status epilepticus (SE) subsequently underwent four consecutive series of the Morris Water Maze. They demonstrated, compared with controls, an early (P46-49), and subsequent (P60-63) disturbance in acquisition, but not in long term retention, of spatial memory. They eventually achieved performance levels similar to those of controls (P74-77, P91-94). These data support the hypothesis that acquisition, but not long term retention, of spatial material is impaired in this model of temporal lobe epilepsy (TLE), probably due to the hippocampal injury that occurs after SE.
Mikati
M A
MA
Laboratory of Developmental Neuropharmacology, Epilepsy Program, Department of Pediatrics, American University of Beirut, 850 Third Avenue, 18th floor, New York, NY 10022, USA. mamikati@aub.edu.lb
Tarif
S
S
Lteif
L
L
Jawad
M A
MA
D000818:Animals; D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology* / Q000523:psychology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D013226:Status Epilepticus / Q000139:chemically induced / Q000523:psychology*; D013550:Swimming
D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid