The pathogenesis of nontypable Haemophilus influenzae otitis media.
Nontypable Haemophilus influenzae is a common cause of otitis media and initiates infection by colonizing the upper respiratory tract. In this article, I review our current understanding of the molecular determinants of H. influenzae colonization and discuss the relationship between colonization and otitis media.
St  Geme
J W
JW
Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Ave., Campus Box 8208, St Louis, MO 63110, USA.
D018829:Adhesins, Bacterial / Q000235:genetics / Q000502:physiology; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology; D000940:Antigenic Variation; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology; D015373:Bacterial Typing Techniques; D002353:Carrier State / Q000453:epidemiology / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D002923:Cilia / Q000382:microbiology; D036781:Fimbriae Proteins; D010861:Fimbriae, Bacterial / Q000502:physiology; D006192:Haemophilus Infections / Q000453:epidemiology / Q000382:microbiology*; D006193:Haemophilus influenzae / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007223:Infant; D008070:Lipopolysaccharides / Q000378:metabolism; D009093:Mucus / Q000382:microbiology; D009876:Operon / Q000235:genetics; D010033:Otitis Media / Q000382:microbiology*; D017354:Point Mutation; D012697:Serine Endopeptidases / Q000502:physiology; D013045:Species Specificity
D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; C117431:HMW1 protein, bacteria; C117432:HMW2 protein, bacteria; C091552:Hap protein, Hemophilus influenzae; C429644:Hia adhesin; C090992:HifA protein, Haemophilus influenzae; D007070:Immunoglobulin A; D008070:Lipopolysaccharides; D036781:Fimbriae Proteins; D012697:Serine Endopeptidases; C021433:IgA-specific serine endopeptidase