Effect of amitriptyline on daily variations in cell composition of immune organs in rats with experimental desynchronosis.
We studied the effects of amitriptyline (preparation stimulating melatonin synthesis in the pineal gland) on daily variations of cell composition in immune organs of Wistar rats with experimental desynchronosis. Amitriptyline administered in the evening restored the daily dynamics of the number of thymus cells.
Litvinenko
G I
GI
Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Verbitskaya
L V
LV
Taradanova
L V
LV
Mel'nikova
E V
EV
Tenditnik
M V
MV
Shurlygina
A V
AV
Trufakin
V A
VA
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D021081:Chronobiology Disorders / Q000188:drug therapy*; D002940:Circadian Rhythm / Q000187:drug effects*; D004195:Disease Models, Animal; D007958:Leukocyte Count; D008027:Light; D018655:Lymphocyte Count; D008221:Lymphoid Tissue / Q000166:cytology / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
D000928:Antidepressive Agents; D000639:Amitriptyline