Nonrandom chromosome changes in Kaposi sarcoma: cytogenetic and FISH results in a new cell line (KS-IMM) and literature review.
The karyotype of a new tumorigenic Kaposi sarcoma (KS)-derived cell line, as defined by cytogenetic and fluorescence in situ hybridization (FISH) analysis is 49,XY,i(1)(q10),i(7)(p10),+i(7) (q10),+der(8)t(8;13)(p11;q11),-13,+del(14)(q22),+der(17)t(1;17)(p13;p13). Our aim was to point out some characteristics and recurrent chromosome changes probably playing a relevant role in the malignant progression of KS, by a comparison of the cytogenetic results obtained in the present study with data from the literature. The interpretation of the cytogenetic results is that KS development occurs by multiple steps: an initial reactive polyclonal cell proliferation is associated with chromosome instability; the cells in a later stage acquire clonal chromosome changes. If many chromosome changes are present, particularly 8q and 1q trisomy, 3p14-->pter deletion, 1p13, 13p14.3, 7q22, 8p11, 13q11, and 19q13 band rearrangements, KS acquires a neoplastic aggressive state.
Casalone
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R
Laboratorio di Citogenetica e Genetica, Ospedale di Circolo e Università dell'Insubria, Viale Borri 57, 21100, Varese, Italy. rosario_c@iol.it
Albini
A
A
Righi
R
R
Granata
P
P
Toniolo
A
A
D002869:Chromosome Aberrations / Q000235:genetics*; D006801:Humans; D007049:Iatrogenic Disease; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D011003:Ploidies; D012514:Sarcoma, Kaposi / Q000235:genetics*; D014407:Tumor Cells, Cultured