title: Transmural heterogeneity of myocardial integrated backscatter in diabetic patients without overt cardiac disease.
abstract: It is important to detect early changes in diabetic myocardium, because some diabetic patients suffer from diabetic cardiomyopathy, especially those with poorer glycemic control or hypertension (HT). To clarify whether ultrasonic tissue characterization can noninvasively detect ultrastructural changes in diabetic myocardium, we analyzed the transmural heterogeneity in myocardial integrated backscatter (THIB) in 20 diabetic patients and 16 normal subjects. THIB was defined as the absolute value of difference of integrated backscatter between the endocardial and epicardial half of the myocardium. THIB in diabetic patients was significantly greater than that in normal subjects. In diabetic patients, there was a significant correlation between glycosylated hemoglobin and THIB, and the greater THIB was shown in patients with HT compared with those without HT. Early changes in the myocardium, related to increased interstitial collagen deposition or other occult cardiomyopathic changes, may be detected on the basis of quantitative analysis of THIB in diabetic patients.
authors.affiliation: Cardiovascular Division, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540, Japan. j-naito@ohn.go.jp
authors.forename: J
authors.initials: J
authors.lastname: Naito
authors.forename: Y
authors.initials: Y
authors.lastname: Koretsune
authors.forename: N
authors.initials: N
authors.lastname: Sakamoto
authors.forename: R
authors.initials: R
authors.lastname: Shutta
authors.forename: J
authors.initials: J
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Yasuoka
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: W
authors.initials: W
authors.lastname: Chin
authors.forename: H
authors.initials: H
authors.lastname: Kusuoka
authors.forename: M
authors.initials: M
authors.lastname: Inoue
mesh_terms: D003094:Collagen / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology; D004452:Echocardiography; D004699:Endocardium / Q000502:physiology / Q000503:physiopathology; D005260:Female; D006321:Heart / Q000502:physiology / Q000503:physiopathology*; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism; D010496:Pericardium / Q000502:physiology / Q000503:physiopathology; D012016:Reference Values
chemical_list: D003094:Collagen