Immune response in Stat2 knockout mice.
Type I IFNs induce gene expression through Stat1 and Stat2, which can in turn associate either to form Stat1 homodimers or the transcription factor ISGF-3. Stat1 homodimers also transduce signals for IFN-gamma. To explore the unique properties of Stat2 and ISGF-3 in type I IFN signaling, its gene was targeted for deletion. Stat2 null mice exhibit a number of defects in immune response. This includes an increased susceptibility to viral infection and the loss of a type I IFN autocrine/ paracrine loop, which in turn regulates several aspects of immune response. Intriguingly, Stat2-deficient fibroblasts exhibit a more significant defect in their response to type I IFNs than macrophages, highlighting tissue-specific differences in the response to this family of ligands.
Park
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Department of Microbiology, Columbia University, New York, New York 10021, USA.
Li
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Cha
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Schindler
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D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology*; D020558:GTP Phosphohydrolases / Q000235:genetics; D017353:Gene Deletion; D015870:Gene Expression; D018390:Gene Targeting; D050856:Interferon Regulatory Factor-1; D050832:Interferon-Stimulated Gene Factor 3; D050834:Interferon-Stimulated Gene Factor 3, gamma Subunit; D016898:Interferon-alpha / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D010750:Phosphoproteins / Q000235:genetics; D018353:Rhabdoviridae Infections / Q000276:immunology; D050795:STAT2 Transcription Factor; D015398:Signal Transduction / Q000276:immunology*; D015534:Trans-Activators / Q000276:immunology*; D014157:Transcription Factors / Q000235:genetics; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology
D004268:DNA-Binding Proteins; D050856:Interferon Regulatory Factor-1; D050832:Interferon-Stimulated Gene Factor 3; D050834:Interferon-Stimulated Gene Factor 3, gamma Subunit; D016898:Interferon-alpha; C494258:Irf1 protein, mouse; C494228:Isgf3g protein, mouse; D010750:Phosphoproteins; D050795:STAT2 Transcription Factor; C494085:Stat2 protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; D007371:Interferon-gamma; D020558:GTP Phosphohydrolases