title: The molecular epidemiology of HIV type 1 of men in Mexico.
abstract: Genotypic characteristics of human immunodeficiency virus type 1 (HIV-1) in Mexico were investigated in a multicenter study that involved centers in five geographic regions of the country. Study samples (n = 65) collected from male patients in 1998-1999 were sequenced within the C2-V5 region of the gp120 env gene. Phylogenetic analysis revealed that subtype B predominates in Mexico. The level of interpatient nucleotide diversity (mean value of 8.9%) was congruent with multiple introductions of the virus and the "aging" epidemic in Mexico. One-third of samples (30.8% of cases) showed polymorphism within the crown of the V3 loop demonstrating non-GPGR motifs. Two new motifs in the V3 loop crown - HPGG and GPEG - were observed. The evolution of the AIDS epidemic in Mexico should be closely monitored since non-B HIV-1 subtypes might be introduced. The nucleotide sequences were deposited in the GenBank under accession numbers AF200855-AF200869, AF200871-AF200892, and AF200894-AF200921.
authors.affiliation: Laboratorio de Inmunología y Virología de la Facultad de Ciencias Biológicas de la Universidad Autónoma de Nuevo León (UNAL), Mexico.
authors.forename: L G
authors.initials: LG
authors.lastname: Rivera-Morales
authors.forename: V A
authors.initials: VA
authors.lastname: Novitsky
authors.forename: J R
authors.initials: JR
authors.lastname: Trujillo
authors.forename: C
authors.initials: C
authors.lastname: Lavalle-Montalvo
authors.forename: C
authors.initials: C
authors.lastname: Cano-Dominguez
authors.forename: J
authors.initials: J
authors.lastname: Ramos-Jimenez
authors.forename: E
authors.initials: E
authors.lastname: Jimenez-Rios
authors.forename: L
authors.initials: L
authors.lastname: Flores-Flores
authors.forename: P
authors.initials: P
authors.lastname: Lopez-Guillen
authors.forename: P
authors.initials: P
authors.lastname: Gilbert
authors.forename: F
authors.initials: F
authors.lastname: Vannberg
authors.forename: R
authors.initials: R
authors.lastname: Tamez-Guerra
authors.forename: C
authors.initials: C
authors.lastname: Rodriguez-Padilla
authors.forename: M
authors.initials: M
authors.lastname: Essex
mesh_terms: D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA
chemical_list: D015699:HIV Envelope Protein gp120