title: Nicorandil can induce severe oral ulceration.
abstract: OBJECTIVE
  To increase physicians' and dentists' awareness that nicorandil is a potential inducer of severe mouth ulceration.
  
  
  METHODS
  Nine new cases of ulceration from 3 European countries were included in this study.
  
  
  RESULTS
  Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia.
  
  
  CONCLUSIONS
  A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients.
authors.affiliation: Department of Oral Medicine, Eastman Dental Institute of Oral Health Care Sciences, University College London, England. CScully@eastman.ucl.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: A M
authors.initials: AM
authors.lastname: Azul
authors.forename: A
authors.initials: A
authors.lastname: Crighton
authors.forename: D
authors.initials: D
authors.lastname: Felix
authors.forename: A
authors.initials: A
authors.lastname: Field
authors.forename: S R
authors.initials: SR
authors.lastname: Porter
mesh_terms: D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000188:drug therapy; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects; D020108:Nicorandil / Q000009:adverse effects*; D019226:Oral Ulcer / Q000139:chemically induced*; D015221:Potassium Channels / Q000187:drug effects; D013997:Time Factors; D014060:Tongue Diseases / Q000139:chemically induced; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D000889:Anti-Arrhythmia Agents; D015221:Potassium Channels; D014665:Vasodilator Agents; D020108:Nicorandil