IL4-R1 (5q31-q33) and FcepsilonRI-betaca (11q13) markers and atopy: a case/control study in a spanish population.
BACKGROUND
Rhinoconjunctivitis and bronchial asthma are atopic diseases with a high prevalence in the Canary Islands (Spain). Given that the most prevalent allergen is the house-dust mite Dermatophagoides pteronyssinus, early detection of genetically susceptible subjects would allow the application of preventive measures. The objective was to investigate the possible association of IL4-R1 (chromosome 5q31-q33) and FcepsilonRI-betaca (chromosome 11q13) markers with the atopic disease in our population.


METHODS
We performed a case/control study in which patients were recruited on the basis of diagnosis of rhinoconjunctivitis and/or bronchial asthma, and positive skin prick test to D. pteronyssinus. Analysis of IL4-R1 and FcepsilonRI-betaca microsatellites was carried out by PCR and electrophoresis in acrylamide gels.


RESULTS
We have not found evidence of association between IL4-R1 and FcepsilonRI-betaca markers and atopic disease in our population. In addition, these markers have shown a high percentage of homozygosis.


CONCLUSIONS
IL4-R1 and FcepsilonRI-betaca markers have not proved to be useful genetic markers for linkage or association studies in our population.
Torres-Galván
M J
MJ
Research Unit, Hospital de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Canary Islands, Spain.
Quiralte
J
J
Pestano
J J
JJ
Ortega
N
N
Blanco
C
C
Castillo
R
R
Carrillo
T
T
Pérez-Aciego
P
P
Sánchez-García
F
F
D000328:Adult; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000276:immunology; D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D003231:Conjunctivitis / Q000276:immunology; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D017455:Receptors, IgE / Q000235:genetics*; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D012220:Rhinitis / Q000276:immunology; D012882:Skin Tests; D013030:Spain
D039741:Antigens, Dermatophagoides; D006023:Glycoproteins; D017455:Receptors, IgE; D019948:Receptors, Interleukin-4