title: Peculiarities of cholinergic regulation of smooth muscles in rabbit pulmonary arteries.
abstract: Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.
authors.affiliation: Siberian Medical University, Tomsk.
authors.forename: L V
authors.initials: LV
authors.lastname: Kapilevich
authors.forename: Y D
authors.initials: YD
authors.lastname: Anfinogenova
authors.forename: M B
authors.initials: MB
authors.lastname: Baskakov
authors.forename: I V
authors.initials: IV
authors.lastname: Kovalev
authors.forename: A V
authors.initials: AV
authors.lastname: Nosarev
authors.forename: M A
authors.initials: MA
authors.lastname: Medvedev
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D018721:Muscarinic Agonists / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010862:Pilocarpine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D004791:Enzyme Inhibitors; D018721:Muscarinic Agonists; D011950:Receptors, Cholinergic; D010862:Pilocarpine; D001285:Atropine; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester