[Transcriptional control by nuclear steroid hormone receptors and endocrine disruptants].
Endocrine disruptant is supposed to act as a ligand to modulate function of nuclear steroid hormone receptors. The nuclear receptors form a superfamily compromising nearly hundred members in human including steroid/thyroid hormones, vitamin A and D, other fat-soluble compounds nuclear receptors, and a subfamily of orphan receptors. The nuclear receptors act as ligand-inducible transcription factors in concert with co-activators in nuclear complexes. In this review, the functions of nuclear receptors are described in terms of transcriptional controls and co-activator complexes.
Kato
S
S
Institute of Molecular and Cellular Biosciences, University of Tokyo.
D000818:Animals; D004703:Endocrine System / Q000187:drug effects*; D004785:Environmental Pollutants / Q000009:adverse effects*; D051548:Histone Acetyltransferases; D006801:Humans; D008024:Ligands; D056920:Nuclear Receptor Coactivator 1; D011987:Receptors, Steroid / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
D004785:Environmental Pollutants; D008024:Ligands; D011987:Receptors, Steroid; D014157:Transcription Factors; D051548:Histone Acetyltransferases; C538859:NCOA1 protein, human; D056920:Nuclear Receptor Coactivator 1