Bordetella pertussis, molecular pathogenesis under multiple aspects.
Recent studies, including those based on genomics, have demonstrated that besides toxins and adhesins, Bordetella pertussis uses many additional virulence determinants. Most of them are part of the BvgAS regulon, although some, in particular iron-uptake systems, are independent of BvgAS. They are regulated by iron, although in one case, the production of a siderophore receptor could be linked to the BvgAS regulon.
Locht
C
C
INSERM U447, Institut Pasteur de Lille, 1 rue du Prof. Calmette, F-59019, Lille Cedex, France. camille.locht@pasteur-lille.fr
Antoine
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R
Jacob-Dubuisson
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F
D018829:Adhesins, Bacterial / Q000235:genetics / Q000276:immunology; D000942:Antigens, Bacterial / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001427:Bacterial Toxins / Q000378:metabolism; D001886:Bordetella pertussis / Q000472:pathogenicity*; D006388:Hemagglutinins / Q000235:genetics / Q000276:immunology; D006801:Humans; D007501:Iron / Q000378:metabolism; D008070:Lipopolysaccharides / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014774:Virulence; D010566:Virulence Factors, Bordetella
D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001427:Bacterial Toxins; C065601:BvgA protein, Bacteria; D006388:Hemagglutinins; D008070:Lipopolysaccharides; D014157:Transcription Factors; D010566:Virulence Factors, Bordetella; C080662:bvgS protein, Bordetella pertussis; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis; D007501:Iron