Clinical trials in HIV-associated cognitive impairment: cognitive and functional outcomes.
Cognitive and functional outcomes are of primary interest in the design of efficacy trials in HIV-associated cognitive impairment. In a longitudinal cohort study, weak associations were found between measures of cognitive performance and commonly used measures of daily functioning (mostly self-report measures) in HIV-infected individuals. Modifications of current functional scales or new functional instruments are needed to assess the clinical relevance of cognitive changes in clinical trials of HIV-associated cognitive impairment.
Schifitto
G
G
Department of Neurology, University of Rochester, NY, USA.
Kieburtz
K
K
McDermott
M P
MP
McArthur
J
J
Marder
K
K
Sacktor
N
N
Palumbo
D
D
Selnes
O
O
Stern
Y
Y
Epstein
L
L
Albert
S
S
D015526:AIDS Dementia Complex / Q000503:physiopathology* / Q000523:psychology*; D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests