Isolation of human faecal bifidobacteria which reduce signs of Salmonella infection when orogastrically dosed to mice.
OBJECTIVE
The aim of the study was to isolate human bifidobacteria that inhibit growth of Salmonella typhimurium in vitro, and provide protection against Salmonella infection in mice.


RESULTS
A total of 92 micro-organisms, which displayed antagonist activity against Salm. typhimurium in vitro, were isolated from human faecal material. Based on their Gram stain status, cultures were pooled and tested for anti-Salmonella activity. The Gram-variable group was the most active. From that group, three bifidobacteria (Laftitrade markB22, B74 and B97) individually showed good pathogen inhibition in vivo.


CONCLUSIONS
Oral administration of certain human bifidobacteria provides protection against Salmonella infection in mice.


CONCLUSIONS
These results indicate that certain bifidobacteria may be used as a prophylaxis for reduced incidence and severity of Salmonella infections.
Henriksson
A
A
CRC for Food Industry Innovation, School of Microbiology and Immunology, University of New South Wales, Sydney, NSW, 2052, Australia. a.henriksson@unsw.edu.au
Conway
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PL
D000818:Animals; D000898:Antibiosis; D001644:Bifidobacterium / Q000254:growth & development / Q000302:isolation & purification*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D012480:Salmonella Infections / Q000382:microbiology / Q000517:prevention & control*; D012486:Salmonella typhimurium / Q000254:growth & development*