[The predictor for platelet recovery after PBSCT].
OBJECTIVE
In order to find out a predictor more accurate, reliable and convenient for platelet recovery capacity after peripheral blood stem cell transplantation (PBSCT).


METHODS
The number of megakaryocyte progenitor cells in PBSC grafts of 17 patients with hematological malignancies or solid tumors was measured by clonogenic (CFU-MK) and flow cytometric assays.


RESULTS
1. The expression of platelet membrane glycoprotein was on < 5% of CD34+ cells. 2. The time needed for platelet recovery was better correlated with the number of CD34+/CD41a+ cells than with the total number of CD34+ cells. 3. There was a close correlation between the number of CFU-MK and the time needed for platelet recovery. 4. Correlation was observed between the number of CD34+/CD41a+ cells and that of CFU-MK.


CONCLUSIONS
The numbers of CD34+/CD41a+ cells and CFU-MK are predictors for platelet recovery after PBSCT, but the former may be a more convenient and reliable marker for clinical study.
Feng
R
R
Department of Hematology, Nanfang Hospital, Guangzhou 510515.
Shimazaki
C
C
Inaba
T
T
D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism
D018952:Antigens, CD34; D019039:Platelet Glycoprotein GPIIb-IIIa Complex