title: Is an effective immune intervention for Alzheimer's disease in prospect?
abstract: Alzheimer's disease is characterized in part by abnormal deposits in the brain of the peptide beta amyloid (Abeta), in the form of plaques. Recent work with a transgenic model of Abeta deposition has uncovered a remarkable capacity of antibodies to prevent or clear these deposits. These experiments offer the attractive possibility, albeit some way in the future, of using antibodies as a therapy in Alzheimer's disease.
authors.affiliation: Departments of Clinical Neurology and Neuropathology, University of Oxford, Radcliffe Infirmary, Woodstock Road, OX2 6HE, Oxford, UK. margaret.esiri@cineuro.ox.ac.uk
authors.forename: M M
authors.initials: MM
authors.lastname: Esiri
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000517:prevention & control / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D006801:Humans; D007114:Immunization; D051379:Mice; D008822:Mice, Transgenic; D010446:Peptide Fragments / Q000276:immunology*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)