Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse.
Consumption of lycopene has been associated with reduced risk of prostate cancer. We have investigated the effects of lycopene, fed as a lycopene-rich tomato oleoresin (LTO) at two doses, on in vivo mutagenesis in prostate, colon, and lungs of lacZ mice. Both short-term benzo[a]pyrene (BaP)- induced and long-term spontaneous mutagenesis were monitored. Non-significant inhibition of spontaneous mutagenesis in prostate and colon was observed at the higher dose of LTO, and the observation of inhibition in colon was facilitated by an unusually high spontaneous mutagenesis rate. BaP-induced mutagenesis was slightly inhibited by LTO in prostate. However, enhancement of BaP-induced-mutagenesis was observed in colon and lung. These results indicate that any antimutagenic effects of LTO may be organospecific.
Guttenplan
J B
JB
Division of Basic Sciences/Biochemistry, New York University, Dental Center, 345 E. 24th St., New York, NY 10100, USA. joseph.guttenplan@nyu.edu
Chen
M
M
Kosinska
W
W
Thompson
S
S
Zhao
Z
Z
Cohen
L A
LA
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001564:Benzo(a)pyrene; D002338:Carotenoids / Q000097:blood / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D004247:DNA / Q000187:drug effects; D004032:Diet; D019587:Dietary Supplements; D007763:Lac Operon; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D000077276:Lycopene; D008297:Male; D051379:Mice; D016296:Mutagenesis; D009153:Mutagens; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D009153:Mutagens; D001564:Benzo(a)pyrene; D002338:Carotenoids; D004247:DNA; D000077276:Lycopene