Gastrointestinal first-pass effect of furosemide in rats.
The first-pass effect of furosemide was investigated in rats. Furosemide intravenous solution (20 mg kg(-1) Lasix), was administered via the jugular vein and the portal vein, orally, and instilled directly into the duodenum of rats. The first-pass effects of furosemide by lung, heart, and liver seemed to be negligible in rats. The absolute bioavailability of furosemide was 28.9 and 48.3% after oral and intraduodenal administration, respectively. Based on the gastrointestinal (GI) recovery study, 68.3 and 69.5% of furosemide were found to have disappeared mainly due to absorption and/or metabolism from rat GI tract after oral and intraduodenal administration, respectively. The results indicate that gastrointestinal and intestinal first-pass effects of furosemide were approximately 40% (68.3-28.9%) and 20% (69.5-48.3%) of the dose, respectively.
Kim
E J
EJ
College of Pharmacy, Seoul National University, Korea.
Han
K S
KS
Lee
M G
MG
D000284:Administration, Oral; D000327:Adsorption; D000818:Animals; D001682:Biological Availability; D004064:Digestive System / Q000187:drug effects; D004232:Diuretics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004386:Duodenum; D005665:Furosemide / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D004232:Diuretics; D005665:Furosemide