title: [Analysis of regions determining resistence to fluoroquinolones in genes gyrA and parC in clinical isolates of Mycoplasma hominis].
abstract: Fifteen strains of M. hominis isolated from patients with urogenital inflammations were analyzed. Variations in the quinolone resistance-determining regions (QRDR) have been found in fluoroquinolone-resistant M. hominis clinical isolates in comparison with the reference PG21 strain. In one isolate, parC had Asn substitute at position 91.
authors.affiliation: Laboratory of Gene Engineering and Immunogenetics, Institute of Physico-Chemical Medicine, Ministry of Health of Russian Federation, Moscow, St. Petersburg.
authors.forename: A E
authors.initials: AE
authors.lastname: Gushchin
authors.forename: V G
authors.initials: VG
authors.lastname: Ladygina
authors.forename: V M
authors.initials: VM
authors.lastname: Govorun
authors.forename: A M
authors.initials: AM
authors.lastname: Taraskina
authors.forename: A M
authors.initials: AM
authors.lastname: Savicheva
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001483:Base Sequence; D027081:DNA Gyrase; D017931:DNA Primers; D027101:DNA Topoisomerase IV; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D024841:Fluoroquinolones; D019535:Mycoplasma hominis / Q000187:drug effects* / Q000235:genetics
chemical_list: D000890:Anti-Infective Agents; D017931:DNA Primers; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II