title: Urinary levels of interleukin-8 (IL-8) and disease activity in patients with IgA nephropathy.
abstract: Using quantitative sandwich ELISA, we studied 27 patients with IgA nephropathy to determine whether the levels of urinary IL-8 might reflect the disease activity. The levels of urinary IL-8 in patients with advanced stage IgA nephropathy were significantly higher than those in the patients with the mild stage of this disease, or in the healthy controls. The results showed a positive significant correlation between the levels of IL-8 and disease activity, i.e., between levels of urinary protein and urinary casts. A significant correlation between levels of urinary IL-8 and tubular function damage was also found. It was thus suggested that measurement of urinary IL-8 might be useful in evaluating the degree of renal injuries and/or prognosis in patients with IgA nephropathy.
authors.affiliation: Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Huang
authors.forename: S
authors.initials: S
authors.lastname: Horikoshi
authors.forename: A
authors.initials: A
authors.lastname: Kurusu
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Funabiki
authors.forename: I
authors.initials: I
authors.lastname: Shirato
authors.forename: Y
authors.initials: Y
authors.lastname: Tomino
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005922:Glomerulonephritis, IGA / Q000652:urine*; D006801:Humans; D016209:Interleukin-8 / Q000652:urine*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011507:Proteinuria; D012016:Reference Values; D014556:Urine / Q000166:cytology
chemical_list: D016209:Interleukin-8; D003404:Creatinine