title: Failure of mebendazole in the treatment of humans with Trichinella spiralis infection at the stage of encapsulating larvae.
abstract: Trichinella spiralis larvae infective for laboratory mice were collected from muscle biopsies performed at different times (from 1 day to 16 months) following the end of treatment, indicating the failure of mebendazole to kill Trichinella parasites when they are encapsulating in muscles.
authors.affiliation: Laboratory of Parasitology, Istituto Superiore di Sanità, Rome, Italy. pozio@iss.it
authors.forename: E
authors.initials: E
authors.lastname: Pozio
authors.forename: D
authors.initials: D
authors.lastname: Sacchini
authors.forename: L
authors.initials: L
authors.lastname: Sacchi
authors.forename: A
authors.initials: A
authors.lastname: Tamburrini
authors.forename: F
authors.initials: F
authors.lastname: Alberici
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D001706:Biopsy; D006801:Humans; D007814:Larva / Q000187:drug effects / Q000502:physiology; D008463:Mebendazole / Q000627:therapeutic use*; D009132:Muscles / Q000469:parasitology; D017211:Treatment Failure; D017160:Trichinella spiralis / Q000187:drug effects / Q000254:growth & development* / Q000302:isolation & purification; D014235:Trichinellosis / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D000969:Antinematodal Agents; D008463:Mebendazole