Immunogenicity of pneumococcal vaccine in heart transplant recipients.
To assess the immunogenicity of pneumococcal vaccine in recipients of heart transplants, we immunized 35 long-term transplantation survivors with pneumococcal vaccine and measured the pre- and postvaccination IgG antibody titers to 5 representative vaccine capsular polysaccharides. Responses of heart transplant recipients to pneumococcal vaccine antigens were generally suppressed.
Blumberg
E A
EA
Department of Medicine and MCP Hahnemann School of Medicine, Philadelphia, PA, USA. blumbere@mail.med.upenn.edu
Brozena
S C
SC
Stutman
P
P
Wood
D
D
Phan
H M
HM
Musher
D M
DM
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D000917:Antibody Formation; D016667:Bacterial Capsules / Q000276:immunology; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007110:Immunity, Active; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D013296:Streptococcus pneumoniae / Q000276:immunology; D014611:Vaccination
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines