Subchronic oral toxicity of a combination of insecticide (HCH) and herbicide (ISP) in male rats.
Rats were treated orally with technical hexachlorocyclohexane (HCH, 12.5, 25 and 50 mg kg-1 day(-1)) and technical isoproturon (ISP 22.5. 45 and 90 mg kg-1 day(-1)) daily for a period of 90 days alone and in combination. Treatment with HCH alone showed mild to severe toxicity and death. Significant changes occurred in liver weight, clinical enzyme profiles, haematological parameters and pathomorphological changes. Treatment with ISP alone did not produce such changes. The combination of HCH and ISP produced changes not suggestive of synergism.
Raizada
R B
RB
Pesticide Toxicology Laboratory, Industrial Toxicology Research Centre. Mahatma Gandhi Marg. PO Box 80. Lucknow 226001. India. intox.itrc.sirnet.ernet.in
Srivastava
M K
MK
Kaushal
R A
RA
Singh
R P
RP
Gupta
K P
KP
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006403:Hematologic Tests; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008136:Longevity / Q000187:drug effects; D008297:Male; D008782:Methylurea Compounds / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010671:Phenylurea Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D018675:Toxicity Tests
D004338:Drug Combinations; D006540:Herbicides; D007306:Insecticides; D008782:Methylurea Compounds; D010671:Phenylurea Compounds; D001556:Hexachlorocyclohexane; C028904:isoproturon