New co-metabolites of the streptazolin pathway.
Variation of the culture conditions of Streptomyces sp. strain A1, which produces streptazolin (1), resulted in the isolation of four new co-metabolites: 5-O-(beta-D-xylopyranosyl)streptazolin (3), 9-hydroxystreptazolin (4), 13-hydroxystreptazolin (5), and streptenol E (6). Their structures were established by spectroscopic and chemical methods. The possible biosynthetic relationship between the streptazolins and the streptenols is discussed.
Puder
C
C
Institut für Organische Chemie, Universität Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Loya
S
S
Hizi
A
A
Zeeck
A
A
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D003470:Culture Media; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010880:Piperidines / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D010880:Piperidines; C428165:streptazolin