Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation.
A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.
Maizels
N
N
Departments of Immunology and Biochemistry, University of Washington Medical School, 1959 NE Pacific Street, Seattle, WA 98195-7650, USA. maizels@u.washington.edu
D000071479:APOBEC-1 Deaminase; D000818:Animals; D003564:Cytidine Deaminase / Q000378:metabolism*; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007107:Immune System / Q000201:enzymology* / Q000276:immunology / Q000378:metabolism; D017578:Immunoglobulin Class Switching / Q000235:genetics* / Q000276:immunology; D009154:Mutation / Q000235:genetics*; D017393:RNA Editing / Q000235:genetics*; D011995:Recombination, Genetic / Q000235:genetics; D013379:Substrate Specificity; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D000098830:AICDA (Activation-Induced Cytidine Deaminase); D000071479:APOBEC-1 Deaminase; C000605089:APOBEC1 protein, human; D003564:Cytidine Deaminase