title: Functional imaging of the brain in sedated newborn infants using near infrared topography during passive knee movement.
abstract: Near infrared topography was used for functional imaging of the sensorimotor cortex of newborn infants during passive knee movement under sedated sleep. Contralateral knee movement caused a marked increase in oxyhemoglobin and total hemoglobin from the baseline values at almost all locations in the primary sensorimotor area of all neonates and a decrease in local deoxyhemoglobin in six of seven neonates. During ipsilateral knee movement, oxyhemoglobin and total hemoglobin showed slighter changes at a few locations, equal to 30% (mean) and 29% (mean) of the changes that occurred with contralateral stimulation, respectively. The mean times corresponding to maximal changes were 11.9 s for oxyhemoglobin and 19.1 s for deoxyhemoglobin, demonstrating that oxyhemoglobin has a much faster response than does deoxyhemoglobin.
authors.affiliation: Department of Pediatrics, Kagawa Medical University, 1750-1 Mikicho, Kitagun, 761-0793, Kagawa, Japan. isobe@kms.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Isobe
authors.forename: T
authors.initials: T
authors.lastname: Kusaka
authors.forename: K
authors.initials: K
authors.lastname: Nagano
authors.forename: K
authors.initials: K
authors.lastname: Okubo
authors.forename: S
authors.initials: S
authors.lastname: Yasuda
authors.forename: M
authors.initials: M
authors.lastname: Kondo
authors.forename: S
authors.initials: S
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Onishi
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007231:Infant, Newborn; D007719:Knee Joint / Q000294:innervation* / Q000502:physiology; D009068:Movement / Q000502:physiology*; D016059:Range of Motion, Articular / Q000502:physiology*; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013840:Thiamylal / Q000494:pharmacology
chemical_list: D006454:Hemoglobins; D006993:Hypnotics and Sedatives; D013840:Thiamylal