title: Effect of 3 mg melatonin on jet lag syndrome in an 8-h eastward flight.
abstract: In order to assess the effect of melatonin on jet lag a field study was undertaken. The process of re-entrainment of circadian melatonin rhythm was investigated in six subjects. Except during 24-h blood sampling, the subjects were exposed to natural zeitgeber (time giver) outdoors and given 3 mg melatonin at 23:00 h. The subjects were exposed to bright sunlight from 3000 to 12000 lx. All of them showed orthodromic re-entrainment with taking melatonin, while two out of the six did not show orthodromic re-entrainment without taking melatonin. Melatonin accelerated the rate of the re-entrainment of the circadian melatonin rhythm. Melatonin was useful to jet travel from Tokyo to Los Angeles.
authors.affiliation: Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan. tositaka@bd.mbn.or.jp
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Ozone
authors.forename: W
authors.initials: W
authors.lastname: Yamadera
authors.forename: K
authors.initials: K
authors.lastname: Hayshida
authors.forename: S
authors.initials: S
authors.lastname: Ushijima
authors.forename: N
authors.initials: N
authors.lastname: Matsunaga
authors.forename: K
authors.initials: K
authors.lastname: Obuchi
authors.forename: H
authors.initials: H
authors.lastname: Sano
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects; D006801:Humans; D020179:Jet Lag Syndrome / Q000097:blood / Q000188:drug therapy*; D008550:Melatonin / Q000008:administration & dosage* / Q000097:blood; D008875:Middle Aged; D017286:Polysomnography; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D008550:Melatonin