title: Near-field scanner for moving molecules.
abstract: We have fabricated using electron beam nanolithography a fixed slit near-field optical scanning device which uses near-field fluorimetry to achieve 200 nm spatial resolution of objects moving over the slits. We explore the basic physics of operating narrow slits in the waveguide cutoff mode and present data from the passage of extended double-stranded DNA molecules passing over the slits as a first example of how this device can be used to do ultrahigh spatial resolution mapping of long polymers.
authors.affiliation: Department of Physics, Princeton University, Princeton, New Jersey 08544, USA.
authors.forename: J O
authors.initials: JO
authors.lastname: Tegenfeldt
authors.forename: O
authors.initials: O
authors.lastname: Bakajin
authors.forename: C F
authors.initials: CF
authors.lastname: Chou
authors.forename: S S
authors.initials: SS
authors.lastname: Chan
authors.forename: R
authors.initials: R
authors.lastname: Austin
authors.forename: W
authors.initials: W
authors.lastname: Fann
authors.forename: L
authors.initials: L
authors.lastname: Liou
authors.forename: E
authors.initials: E
authors.lastname: Chan
authors.forename: T
authors.initials: T
authors.lastname: Duke
authors.forename: E C
authors.initials: EC
authors.lastname: Cox
mesh_terms: D000465:Algorithms; D004247:DNA / Q000737:chemistry*; D005453:Fluorescence; D005470:Fluorometry; D008855:Microscopy, Electron, Scanning
chemical_list: D004247:DNA