The use of designer rats in the genetic dissection of hypertension.
The rat is a well-established model for hypertension research, in both physiologic and pharmacologic study. Quantitative trait loci (QTL) for blood pressure and related phenotypes have been described on every rat chromosome; therefore, more simplified models must be generated to identify and study the function of the gene(s) located by QTL analysis. Designer rat strains, such as congenic and consomic strains, which share phenotypic and genotypic characteristics with humans but with a greatly simplified genetic background, would yield a powerful platform for functional studies, especially when combined with microarray technologies. Development of these designer rats would result in better-defined disease models that can be used in physiologic and applied pharmacologic studies to better treat human essential hypertension.
Kwitek-Black
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AE
Department of Physiology and the Human Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, USA. ablack@mcw.edu
Jacob
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HJ
D000818:Animals; D020296:Animals, Congenic / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D023421:Models, Animal; D019655:Quantitative Trait, Heritable; D051381:Rats / Q000235:genetics*