The role of Notch and Rho GTPase signaling in the control of dendritic development.
Dendritic patterning exerts a profound influence on neuronal connectivity. Recent studies indicate that mammalian Notch receptors are expressed by postmitotic neurons and that Notch signaling has a considerable influence on dendritic growth and branching. Investigations into the intracellular effectors of dendritic development have revealed that dendritic growth and branching are differentially affected by activation of the Rho-family GTPases, RhoA, Rac1, and Cdc42. These observations suggest that the differential activation of Notch receptors and Rho-family GTPases by extracellular signals may be important in the generation of morphological diversity in the developing nervous system.
Redmond
L
L
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore MD 21205, USA. lredmond@jhmi.edu
Ghosh
A
A
D000818:Animals; D003712:Dendrites / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D051880:Receptors, Notch; D015398:Signal Transduction / Q000502:physiology*
D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch