title: Knockout of renin-angiotensin system genes: effects on vascular development.
abstract: Pharmacologic inhibition of the renin-angiotensin system (RAS) is a widely accepted and effective treatment for hypertension. However, in the past several years, much attention has been focused on additional roles of the RAS including the possibility that its end-product, angiotensin II, could elicit end-organ pathologies independent of its effect on blood pressure. The ability to selectively delete genes in mice (by homologous recombination or gene knockouts) has led to new--and sometimes surprising--insights into the roles of the RAS in the developmental modeling and pathologic remodeling of the heart and blood vessels.
authors.affiliation: Department of Pathology, University of Washington, Vascular Biology, Seattle 98195-7335, USA.
authors.forename: D
authors.initials: D
authors.lastname: Methot
authors.forename: T L
authors.initials: TL
authors.lastname: Reudelhuber
mesh_terms: D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D001808:Blood Vessels / Q000254:growth & development; D006321:Heart / Q000254:growth & development; D051379:Mice; D018345:Mice, Knockout; D012084:Renin-Angiotensin System / Q000235:genetics* / Q000502:physiology*
chemical_list: D000808:Angiotensinogen