ITF expression in mouse brain during acquisition of alcohol self-administration.
Expression of inducible transcription factors (ITFs) c-Fos and FosB was investigated during acquisition of alcohol drinking in C57BL/6J mice. A slight but statistically significant increase in c-Fos expression was found in the Edinger-Westphal nucleus (EW) of animals consuming 2% ethanol/10% sucrose for the first time. Stronger expression of c-Fos in EW was found in animals repeatedly consuming ethanol-containing solutions. These findings underscore the potential importance of EW in alcohol-related behaviors.
Ryabinin
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Department of Behavioral Neuroscience, L470, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA. ryabinin@ohsu.edu
Bachtell
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RK
Freeman
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Risinger
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FO
D000428:Alcohol Drinking / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D002492:Central Nervous System Depressants / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D017781:Genes, Immediate-Early / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D012646:Self Administration
D002492:Central Nervous System Depressants; D016760:Proto-Oncogene Proteins c-fos; D000431:Ethanol