Noninvasive detection of genetic instability in cells from prostatic secretion as a marker of prostate cancer.
We present a clinical and molecular study of a series of specific loss of heterozygosity (LOH) indicators which, together with PSA, increase the predictability of cancer in early prostate cancer patients. Considering a positive biopsy as the standard reference, the testing parameters for LOH testing are better than the PSA F/T ratio (<25%), suggesting that this noninvasive approach to detecting early prostate cancer could be very useful as a new tool to optimize the indications for iterative prostate biopsies.
Cussenot
O
O
CeRePP-EA3104 and Urogène, Génopole, 4 Rue Pierre Fontaine, F-91000, Evry, France
Teillac
P
P
Berthon
P
P
Latil
A
A