title: MR-guided percutaneous cryotherapy of the liver: in vivo evaluation with histologic correlation in an animal model.
abstract: The purpose of this study was to evaluate the feasibility of MR-guided percutaneous cryotherapy of the porcine liver and to correlate the resulting tissue necrosis with MR imaging and histology. Using an MR-compatible, argon-based cryotherapy system (CryoHit; Galil Medical Ltd., Israel) with 2- and 3-mm diameter tapered cryotherapy probes, MR-guided percutaneous cryotherapy was performed in seven pigs (mean body weight, 40 kg) under general anesthesia in a short-bore magnet (1.5 T ACS NT; Philips, The Netherlands) using an ultrafast T2-weighted single-shot LoLo TSE sequence and a T1-weighted gradient-echo sequence. The frozen liver tissue was depicted accurately on fast T2- and T1-weighted sequences, providing precise delineation of the ablated tissue volume. On follow-up postcontrast MR controls, the cryolesions appeared avascular. They decreased in size compared with the initially frozen volume down to 70% at a 2-week follow-up. Histologically, a coagulation necrosis with a close correlation to the MR follow-up examinations was objectified. No cryotherapy-related complications occurred. J. Magn. Reson. Imaging 2001;13:50-56.
authors.affiliation: Department of Diagnostic Radiology, University of Technology, Pauwelsstrasse 30, 52074 Aachen, Germany. tacke@rad.rwth-aachen.de
authors.forename: J
authors.initials: J
authors.lastname: Tacke
authors.forename: G
authors.initials: G
authors.lastname: Adam
authors.forename: P
authors.initials: P
authors.lastname: Haage
authors.forename: B
authors.initials: B
authors.lastname: Sellhaus
authors.forename: S
authors.initials: S
authors.lastname: Grosskortenhaus
authors.forename: R W
authors.initials: RW
authors.lastname: Günther
mesh_terms: D000818:Animals; D003452:Cryosurgery / Q000295:instrumentation; D005240:Feasibility Studies; D005500:Follow-Up Studies; D008099:Liver / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008297:Male; D009336:Necrosis; D013552:Swine; D013997:Time Factors