Effect of Semax on homeostasis of gastric mucosa in albino rats.
The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg.
Zhuikova
S E
SE
Department of Human and Animal Physiology, Biological Faculty of M. V. Lomonosov Moscow State University.
Smirnova
E A
EA
Bakaeva
Z V
ZV
Samonina
G E
GE
Ashmarin
I P
IP
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects* / Q000503:physiopathology; D006706:Homeostasis / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000503:physiopathology
D018696:Neuroprotective Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone