A novel reciprocal (10;17)(p11.2;q23) in myxoid fibrosarcoma.
Recurring reciprocal translocations have been identified as the primary chromosome aberrations in a number of neoplasms. These aberrations are often closely associated with particular morphologic or phenotypic subtypes of tumors and in some cases have prognostic implications. We have identified a novel reciprocal t(10;17)(p11.2;q23) in a case of low-grade myxoid fibrosarcoma, which may prove to be a new tumor specific chromosome aberration.
Sawyer
J R
JR
Department of Pathology, University of Arkansas for Medical Sciences, 4301 W. Markham, Little Rock, AR, USA.
Binz
R L
RL
Gilliland
J C
JC
Nicholas
R W
RW
Thomas
J R
JR
D002879:Chromosomes, Human, Pair 10; D002886:Chromosomes, Human, Pair 17; D005354:Fibrosarcoma / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D013848:Thigh / Q000473:pathology / Q000601:surgery; D014178:Translocation, Genetic