title: Progression of cervical lesions in HIV-seropositive women: a cytological study.
abstract: It has been reported that cervical intraepithelial lesions have a more aggressive course in HIV-seropositive than in HIV-seronegative women. In the present investigation, the progression of these cervical lesions was studied in a group of HIV-seropositive women. Of 1,587 patients, 200 (12.6%) had a cytological diagnosis of squamous intraepithelial lesion (SIL) or invasive carcinoma. In 409 patients, more than one cytological smear was collected in 3(1/2) years. Progression occurred in 39 cases. In 24 (61.5%), the first diagnosis was benign cellular changes (BCC) and the second was low-grade SIL (LSIL) (1-yr interval in 21 cases); in 11 (28.2%), the first was BCC, and the second, high-grade SIL (HSIL) (1-yr interval in 9 cases); in 2 (5.0%), the first diagnosis was LSIL. and the second, HSIL (1-yr interval); in 2 (5.0%), the first was HSIL, and the second, invasive carcinoma (2-yr interval). These results point to the importance of cervical cytologic surveillance in HIV-seropositive patients.
authors.affiliation: Section of Pathology, Emílio Ribas Institute, Av. Dr Arnaldo 165, 01246-902 São Paulo, S.P., Brazil. calore@sti.com.br
authors.forename: E E
authors.initials: EE
authors.lastname: Calore
authors.forename: S M
authors.initials: SM
authors.lastname: Pereira
authors.forename: M J
authors.initials: MJ
authors.lastname: Cavaliere
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D002277:Carcinoma / Q000145:classification / Q000473:pathology / Q000821:virology; D018450:Disease Progression; D005260:Female; D006679:HIV Seropositivity; D006801:Humans; D009361:Neoplasm Invasiveness; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology; D012189:Retrospective Studies; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000145:classification / Q000473:pathology* / Q000821:virology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000145:classification / Q000473:pathology* / Q000821:virology