Regulation of neural determination by evolutionarily conserved signals: anti-BMP factors and what next?
The evolutionary conservation of Chordin/bone morphogenetic protein (BMP) signaling supports the hypothesis of dorsal-ventral axis inversion of vertebrates and invertebrates, and implies that the invention of a central nervous system occurred only once during animal evolution. This hypothesis is further strengthened by recent findings of the conservation of downstream genes and modifier genes of neural induction. On the other hand, in contrast with such gross conservation, recent data suggest that the requirement for some signals in neural determination may differ even within the vertebrate subphylum.
Sasai
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Department of Medical Embryology and Neurobiology, Institute for Frontier Medical Sciences, Kyoto University, Sakyo, Kyoto 606-8507, Japan. sasai@phy.med.kyoto-u.ac.jp
D000663:Amphibians; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics*; D002454:Cell Differentiation / Q000502:physiology; D017124:Conserved Sequence / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D004330:Drosophila; D024002:HMGB Proteins; D006801:Humans; D008322:Mammals; D009474:Neurons / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics; D055748:SOXB1 Transcription Factors; D015398:Signal Transduction / Q000235:genetics*; D014157:Transcription Factors
D019485:Bone Morphogenetic Proteins; D004268:DNA-Binding Proteins; D024002:HMGB Proteins; D009687:Nuclear Proteins; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors