Model Systems: transgenic mouse models for measles pathogenesis.
Studies of the diseases caused by measles virus (MV) in humans have been restricted owing to the lack of suitable animal models. The discovery of cellular receptors for MV entry has facilitated the development of transgenic mice that are susceptible to MV infection, and that mimic certain aspects of the central nervous system diseases and immunosuppression that can occur in infected humans. Moreover, such mouse models have allowed a clearer understanding of the contributions of the innate and adaptive immune response following infection, and will no doubt be important tools in the future for the development of new antiviral and vaccine reagents.
Manchester
M
M
Dept of Neuropharmacology (IMM6), The Scripps Research Institute, La Jolla, CA 92037, USA. marim@scripps.edu
Rall
G F
GF
D000208:Acute Disease; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000209:etiology; D002648:Child; D004195:Disease Models, Animal; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D007136:Immunoglobulins / Q000378:metabolism; D008457:Measles / Q000150:complications / Q000276:immunology / Q000821:virology*; D008459:Measles virus / Q000235:genetics / Q000472:pathogenicity*; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics / Q000378:metabolism / Q000821:virology*; D011956:Receptors, Cell Surface; D011991:Receptors, Virus / Q000378:metabolism; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1
D015703:Antigens, CD; C497857:CD46 protein, human; D006023:Glycoproteins; D007136:Immunoglobulins; C497859:Mcp protein, mouse; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1