title: [Insulin-dependent diabetes mellitus as a possible sequelae of treatment of viral hepatitis with interferon-alpha] .
abstract: Treatment of chronic hepatitis with interferon-alpha is an increasingly used successful therapeutic procedure. In the literature in recent years data accumulated on side-effects of interferon therapy, among which relatively frequently insulin dependent diabetes is mentioned. Interferon-alpha enhances the expression of molecules of the histocompatible complex I which may cause in genetically predisposed subjects the clinical manifestation of diabetes. It is therefore recommended to monitor before the onset of treatment and during interferon treatment the auto-antibody formation against islet cells and against insulin which signalizes changes in the pancreas before the clinical disease proper.
authors.affiliation: Ustav preventívnej a klinickej medicíny, Bratislava.
authors.forename: A
authors.initials: A
authors.lastname: Petrovicová
mesh_terms: D000998:Antiviral Agents / Q000009:adverse effects*; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006525:Hepatitis, Viral, Human / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha