An observational evaluation of the rate of awakening after isoflurane or desflurane used in daily clinical practice.
OBJECTIVE
To evaluate the rate of awakening after desflurane (D) or isoflurane (I) anesthesia when used during daily clinical practice.


METHODS
Observational prospective study.


METHODS
University-affiliated metropolitan hospital.


METHODS
68 ASA physical status I and II patients (18-75 yrs) scheduled for abdominal surgeries.


METHODS
Patients scheduled for abdominal surgery of various duration received either D or I. No time was specified for discontinuation of the inhaled drugs at the end of the surgery. T0 for recovery parameters was stated as the end of the surgery. A p-value < 0.05 was considered as significant. Results are expressed as medians and ranges.


RESULTS
68 patients (32 in D group and 36 in I group) were analyzed. Patient demographic data were similar between the two groups. Duration of surgery was 151 minutes (83-428 min) and 174 minutes (40-552 min) for I and D, respectively. Extubation occurred earlier after D (18 min [9-35 min]) as compared to I (32 min [7-77 min]). Time to reach the Aldrete score at 10 was faster after D (30 min [12-45]) as compared to I (46 min [15-110]). Unlike I, the rate of awakening after D was independent of the duration of surgery. The differences between D and I reached statistical significance in surgical procedures lasting more than 100 minutes.


CONCLUSIONS
Used during routine conditions, D allows for faster recovery than I in surgical procedures lasting more than 100 minutes. The rate of awakening after D remained independent of the duration of the surgical procedure.
Beaussier
M
M
Department of Anesthesia and Intensive Care, Pharmacy, and Digestive Surgical Unit, St-Antoine University Hospital, Paris, France. mark.beaussier@sat.ap-hop-paris.fr
Decorps
A
A
Tilleul
P
P
Balladur
P
P
Lienhart
A
A
D000005:Abdomen / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation; D000077335:Desflurane; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D007530:Isoflurane / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane