The combination of HLA-DR1 and HLA-DR53 protects against MS.
The DRB1/3/4/5 loci from 97 patients with MS and 100 normal control subjects were analyzed. DRB1*15 increased the risk of MS (OR = 4.2, p < 0.0001), whereas DR1 decreased the risk (OR = 0.30, p(c )= 0.005). In analyses of the DR1 risk in relation to DR51, DR52, and DR53 alleles, DR1 in combination with DR53 was found to have the strongest protective effect against MS in all subjects (OR = 0.05, p < 0.0001) and in DRB1*15-negative subjects (OR = 0.09, p(c )= 0.026). DR53 may be an important allele or haplotype, acting together with DR1 to protect against MS.
Luomala
M
M
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Finland. mari.luomala@csc.fi
Elovaara
I
I
Ukkonen
M
M
Koivula
T
T
Lehtimäki
T
T
D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D015798:HLA-DR1 Antigen / Q000235:genetics*; D059845:HLA-DRB4 Chains; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology
D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; C050610:HLA-DR53; D059845:HLA-DRB4 Chains