The canine as a model of human cognitive aging: recent developments.
1. Aged dogs display many of the cognitive impairments associated with aging and dementia. 2. Aged dogs, like humans, display a wide range of individual variability in cognitive functioning (i.e., different cognitive functions decline at different rates in aged dogs). 3. Different categories of aged canines can be identified on the basis of neuropsychological test performance, and these categories can be used to model different subgroups of aged humans (i.e., dementia, mild cognitive impairment and successful aging). 4. Additional research is required to further validate the dog as a model of human cognitive aging and dementia.
Adams
B
B
Department of Pharmacology, University of Toronto, Ontario, Canada.
Chan
A
A
Callahan
H
H
Milgram
N W
NW
D000375:Aging / Q000473:pathology*; D000818:Animals; D003071:Cognition; D004193:Discrimination Learning; D004195:Disease Models, Animal; D006801:Humans; D008568:Memory; D012660:Semantics