Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress.
Argon anoxia and glucose deprivation were used for modeling of ischemic damage in the cultures of cerebellar granule cells. Protective effect of peptide piracetam analogue GVS-111 was demonstrated. GVS-111 prevented neurodegeneration induced by glutamate and oxidative stress. In contrast to GVS-111, piracetam did not attenuate neurocytotoxic effect of glutamate.
Andreeva
N A
NA
Brain Research Institute, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. nadja@ ncyt.brain.msk.ru
Stel'mashuk
E V
EV
Isaev
N K
NK
Ostrovskaya
R U
RU
Gudasheva
T A
TA
Viktorov
I V
IV
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D004151:Dipeptides / Q000494:pharmacology*; D005947:Glucose / Q000172:deficiency; D018698:Glutamic Acid / Q000378:metabolism / Q000633:toxicity*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018697:Nootropic Agents / Q000494:pharmacology*; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D004151:Dipeptides; D018696:Neuroprotective Agents; D018697:Nootropic Agents; D018698:Glutamic Acid; C103871:ethyl phenylacetyl-Pro-Gly; D015763:2-Amino-5-phosphonovalerate; D005947:Glucose; D010100:Oxygen; D010889:Piracetam