Canine models for human genetic neurodegenerative diseases.
1. Canine models of human neurodegenerative disorders are uncommon. However, the similarity between canines and humans in body sizes and physiology provides an exceptional opportunity to use these models to study human diseases. 2. The authors will present a review on the neurological deficits that have been observed in canine models of genetic neurodegenerative diseases, and summarize the current gene therapy treatments being developed for some of these conditions.
Barsoum
S C
SC
Department of Pediatric, McMaster University, Ontario, Canada.
Callahan
H M
HM
Robinson
K
K
Chang
P L
PL
D000818:Animals; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D004195:Disease Models, Animal; D004285:Dogs; D015316:Genetic Therapy; D020271:Heredodegenerative Disorders, Nervous System / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy