Urethane anaesthesia could partly mask antinociceptive effects of non-steroidal anti-inflammatory drugs: a spinal c-Fos protein study.
Urethane anaesthesia strongly reduced the peripheral edema (31+/-5 and 96+/-8% reduction of carrageenan-enhanced paw and ankle diameters, respectively; P<0.001 for both) and the spinal c-Fos protein expression (71+/-4% reduction of the number of c-Fos protein-labeled nuclei; P<0.001), 3 h after intraplantar injection of carrageenan in rats. In urethane anaesthetised rats, i.v. injection of racemic-flurbiprofen (0.3, 3 and 9 mg/kg) has weaker effects on carrageenan-evoked spinal c-Fos protein expression and peripheral edema than those previously described in the same inflammatory nociceptive model in awake rats.
Buritova
J
J
Unité de Recherches de Physiopharmacologie du Système Nerveux, INSERM U161 and EPHE, 2 rue d'Alésia, F-75014, Paris, France. buritova@broca.inserm.fr
Besson
J M
JM
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D002452:Cell Count; D004195:Disease Models, Animal; D004347:Drug Interactions / Q000502:physiology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005480:Flurbiprofen / Q000494:pharmacology; D008297:Male; D009619:Nociceptors / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism; D010147:Pain Measurement / Q000187:drug effects; D020671:Posterior Horn Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014520:Urethane / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016760:Proto-Oncogene Proteins c-fos; D014520:Urethane; D005480:Flurbiprofen; D002351:Carrageenan