Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.
Nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (HPT), isolated from the peel of Citrus plants, were examined for the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide, as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter. HPT exhibited the remarkable anti-tumor-initiating effect on mouse skin and it suggested the possibility of HPT being a chemopreventive agent against nitric oxide (NO) carcinogenesis.
Iwase
Y
Y
Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koshien Kyubancho, Nishinomiya, 663-8179, Hyogo, Japan.
Takemura
Y
Y
Ju-ichi
M
M
Yano
M
M
Ito
C
C
Furukawa
H
H
Mukainaka
T
T
Kuchide
M
M
Tokuda
H
H
Nishino
H
H
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D002273:Carcinogens / Q000008:administration & dosage; D002957:Citrus / Q000737:chemistry*; D005260:Female; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology*; D051379:Mice; D009574:Nitro Compounds / Q000008:administration & dosage; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013047:Specific Pathogen-Free Organisms; D013755:Tetradecanoylphorbol Acetate / Q000009:adverse effects; D013997:Time Factors
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D047309:Flavones; D005419:Flavonoids; D009574:Nitro Compounds; D010936:Plant Extracts; C101316:methyl-2-hydroxyimino-5-nitro-6-methoxy-3-hexeneamide; C059294:3,3',4',5,6,7,8-heptamethoxyflavone; D015127:9,10-Dimethyl-1,2-benzanthracene; C008661:nobiletin; D013755:Tetradecanoylphorbol Acetate