Outbreak of Pasteurella pneumotropica in a closed colony of STOCK-Cd28(tm1Mak) mice.
Fifteen mice with Pasteurella pneumotropica orbital abscesses were noted in mice that were homozygous for a targeted Cd28 gene mutation. Only one mouse heterozygous for the Cd28 mutation was affected. According to phenotypic reactions and 16S rDNA sequencing, the isolates were most similar to biotype Heyl. This article provides evidence for an immunologic basis of susceptibility to P. pneumotropica infection. Fifteen mice with Pasteurella pneumotropica orbital abscesses were noted in mice that were homozygous for a targeted Cd28 gene mutation. Only one mouse heterozygous for the Cd28 mutation was affected. According to phenotypic reactions and 16S rDNA sequencing, the isolates were most similar to biotype Heyl. This article provides evidence for an immunologic basis of susceptibility to P. pneumotropica infection.
Artwohl
J E
JE
Biologic Resources Lab, University of Illinois at Chicago, 1840 West Taylor Street MC 533, Chicago, IL 60612, USA.
Flynn
J C
JC
Bunte
R M
RM
Angen
O
O
Herold
K C
KC
D000818:Animals; D000830:Animals, Laboratory; D018106:CD28 Antigens / Q000235:genetics / Q000502:physiology; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009894:Opportunistic Infections / Q000453:epidemiology / Q000662:veterinary; D010325:Pasteurella / Q000145:classification / Q000302:isolation & purification; D010326:Pasteurella Infections / Q000453:epidemiology / Q000662:veterinary*; D012376:Rodent Diseases / Q000453:epidemiology* / Q000382:microbiology
D018106:CD28 Antigens