SPECT imaging of the dopamine transporter in juvenile-onset dystonia.
Juvenile-onset dystonia that improves after levodopa may occur in both dopa-responsive dystonia (DRD) and juvenile parkinsonism (JP), clinically similar conditions with different prognoses and management goals. The authors show normal striatal uptake of the dopamine transporter ligand FP-CIT with SPECT in a clinically atypical case of DRD, in contrast to the reduced uptake observed in JP.
O'Sullivan
J D
JD
Reta Lila Weston Institute of Neurological Studies, Royal Free and University College Medical School, University College London, UK.
Costa
D C
DC
Gacinovic
S
S
Lees
A J
AJ
D000293:Adolescent; D002352:Carrier Proteins / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D020821:Dystonic Disorders / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D015899:Tomography, Emission-Computed, Single-Photon
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins