The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation.
The endoplasmic reticulum is the entry point into the secretory pathway. To acquire a correct conformation, secretory proteins encounter the endoplasmic reticulum molecular machines of folding, quality control, signaling and disposal, which function as an integrated mechanism. The creation of such a molecular network, spatially regulated, suggests how the endoplasmic reticulum promotes the release of correctly folded secretory proteins.
Chevet
E
E
Anatomy and Cell Biology, McGill University, Montreal, Quebec, H3A 2B2, Canada.
Cameron
P H
PH
Pelletier
M F
MF
Thomas
D Y
DY
Bergeron
J J
JJ
D004721:Endoplasmic Reticulum / Q000502:physiology*; D008954:Models, Biological; D017510:Protein Folding; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
D011506:Proteins