[Progress in targeting gene therapy].
In recent years the research on targeting in gene therapy has made much exciting progress. Many new technologies show great promising prospects such as the delivery of therapeutic gene to targeted cells by some antibodies or ligands, the use of specific gene promoter to tightly control gene expression within disease microenvironment, the use of some orally taken drugs for regulating expression time and expression level of DNA, and the targeted correction of deleted or mutated gene using RNA/DNA oligonucleotides. Yet, researchers still have a long way to go in order to reach the goal of applying the targeting gene therapy in clinical practice.
Xie
X
X
Cancer Center, the First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P.R. China. yuquanwei@mail.cninfo.net
Tian
L
L
Wei
Y
Y
D015870:Gene Expression; D018390:Gene Targeting; D015316:Genetic Therapy; D006801:Humans