Immunosuppressive and non-immunosuppressive immunophilin ligands improve H(2)O(2)-induced cell damage by increasing glutathione levels in NG108-15 cells.
We examined the effects of FK506 and its non-immunosuppressive derivative, GPI1046, on H(2)O(2)-induced oxidative cell damage in NG 108-15 cells. Our results suggest that the protective properties of GPI1046 are equipotent with those of FK506 and may be mediated by increased intracellular concentrations of glutathione (GSH). Thus, non-immunosuppressive immunophilin ligands such as GPI1046 might be potentially for neurodegenerative diseases, particularly since they do not have serious side effects such as immune deficiency.
Tanaka
K
K
Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School, 2-5-1 Shikatacho, 700-8558, Okayama, Japan. kntanaka@cc.okayama-u.ac.jp
Fujita
N
N
Yoshioka
M
M
Ogawa
N
N
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003124:Colorimetry; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D020104:Immunophilins; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011759:Pyrrolidines / Q000494:pharmacology; D016559:Tacrolimus / Q000494:pharmacology
C104949:GPI 1046; D007166:Immunosuppressive Agents; D018696:Neuroprotective Agents; D011759:Pyrrolidines; D006861:Hydrogen Peroxide; D020104:Immunophilins; D005978:Glutathione; D016559:Tacrolimus