Juvenile hyaline fibromatosis complicated with oral squamous cell carcinoma: a case report.
A 45-year-old woman was referred because of swelling of the palate, gingival hypertrophy, and multiple cutaneous tumors. She had many cutaneous tumors, which covered most of her body, and she also displayed contractures of the major joints. Maxillary and mandibular gingival hypertrophy, malposition of the teeth, and swelling of the hard palate were the oral findings. The histopathologic features of the cutaneous and gingival tumors were consistent with hyaline fibromatosis, and the swelling of the palate proved to be a squamous cell carcinoma. The carcinoma was treated with tegafur/uracil and seemed to respond to this therapy.
Kawasaki
G
G
First Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan. gkawa@net.nagasaki-u.ac.jp
Yanamoto
S
S
Mizuno
A
A
Fujita
S
S
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003286:Contracture / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005350:Fibroma / Q000473:pathology*; D005886:Gingival Hypertrophy / Q000473:pathology; D006801:Humans; D008310:Malocclusion / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010157:Palatal Neoplasms / Q000473:pathology*; D021362:Palate, Hard / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D005641:Tegafur; D014498:Uracil