Involvement of GABA(A) receptor in modulation of jaw muscle activity evoked by mustard oil application to the rat temporomandibular joint.
The effect of intrathecal administration of the GABA(A) receptor antagonist bicuculline methylbromide on jaw muscle electromyographic (EMG) activity evoked by mustard oil injection into the rat temporomandibular joint was studied. Bicuculline given prior to mustard oil augmented the EMG activity evoked by mustard oil, and "rekindling" of EMG activity was induced by bicuculline given 30 min after mustard oil. These results suggest that central GABA(A) receptors modulate reflex responses to noxious craniofacial stimuli.
Seo
K
K
Department of Dental Anesthesia, Niigata University Dental Hospital, 2-5274 Gakkocho-dori, Niigata city, Niigata 951-8514, Japan. seo@dent.niigata-u.ac.jp
Hu
J W
JW
Cairns
B E
BE
Someya
G
G
D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004576:Electromyography / Q000187:drug effects; D007839:Functional Laterality; D018756:GABA Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D007278:Injections, Spinal; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D008410:Masticatory Muscles / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D008845:Microinjections; D009149:Mustard Plant; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010938:Plant Oils; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D013704:Temporomandibular Joint / Q000187:drug effects / Q000502:physiology*
D018756:GABA Antagonists; D010936:Plant Extracts; D010938:Plant Oils; D011963:Receptors, GABA-A; C036615:bicuculline methobromide; C027793:mustard oil; D001640:Bicuculline