title: Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors.
abstract: In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1',3'-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.
authors.affiliation: Molecular and Structural Neurobiology and Gene Therapy Program, State University of New York, Buffalo, New York 14214, USA.
authors.forename: H
authors.initials: H
authors.lastname: Peng
authors.forename: J
authors.initials: J
authors.lastname: Moffett
authors.forename: J
authors.initials: J
authors.lastname: Myers
authors.forename: X
authors.initials: X
authors.lastname: Fang
authors.forename: E K
authors.initials: EK
authors.lastname: Stachowiak
authors.forename: P
authors.initials: P
authors.lastname: Maher
authors.forename: E
authors.initials: E
authors.lastname: Kratz
authors.forename: J
authors.initials: J
authors.lastname: Hines
authors.forename: S J
authors.initials: SJ
authors.lastname: Fluharty
authors.forename: E
authors.initials: E
authors.lastname: Mizukoshi
authors.forename: D C
authors.initials: DC
authors.lastname: Bloom
authors.forename: M K
authors.initials: MK
authors.lastname: Stachowiak
mesh_terms: D000313:Adrenal Medulla / Q000166:cytology / Q000378:metabolism; D000804:Angiotensin II / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites; D002417:Cattle; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D018983:DNA Footprinting; D003850:Deoxyribonuclease I / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D011725:Pyridines / Q000494:pharmacology; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D020218:Response Elements / Q000502:physiology; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
chemical_list: D007093:Imidazoles; D011725:Pyridines; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D011994:Recombinant Proteins; D015534:Trans-Activators; D016222:Fibroblast Growth Factor 2; D000804:Angiotensin II; C073402:PD 123319; D014443:Tyrosine; C074793:angiotensin II, Sar(1)-; D003850:Deoxyribonuclease I