title: IL4-R1 (5q31-q33) and FcepsilonRI-betaca (11q13) markers and atopy: a case/control study in a spanish population.
abstract: BACKGROUND
  Rhinoconjunctivitis and bronchial asthma are atopic diseases with a high prevalence in the Canary Islands (Spain). Given that the most prevalent allergen is the house-dust mite Dermatophagoides pteronyssinus, early detection of genetically susceptible subjects would allow the application of preventive measures. The objective was to investigate the possible association of IL4-R1 (chromosome 5q31-q33) and FcepsilonRI-betaca (chromosome 11q13) markers with the atopic disease in our population.
  
  
  METHODS
  We performed a case/control study in which patients were recruited on the basis of diagnosis of rhinoconjunctivitis and/or bronchial asthma, and positive skin prick test to D. pteronyssinus. Analysis of IL4-R1 and FcepsilonRI-betaca microsatellites was carried out by PCR and electrophoresis in acrylamide gels.
  
  
  RESULTS
  We have not found evidence of association between IL4-R1 and FcepsilonRI-betaca markers and atopic disease in our population. In addition, these markers have shown a high percentage of homozygosis.
  
  
  CONCLUSIONS
  IL4-R1 and FcepsilonRI-betaca markers have not proved to be useful genetic markers for linkage or association studies in our population.
authors.affiliation: Research Unit, Hospital de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Canary Islands, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Torres-Galván
authors.forename: J
authors.initials: J
authors.lastname: Quiralte
authors.forename: J J
authors.initials: JJ
authors.lastname: Pestano
authors.forename: N
authors.initials: N
authors.lastname: Ortega
authors.forename: C
authors.initials: C
authors.lastname: Blanco
authors.forename: R
authors.initials: R
authors.lastname: Castillo
authors.forename: T
authors.initials: T
authors.lastname: Carrillo
authors.forename: P
authors.initials: P
authors.lastname: Pérez-Aciego
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-García
mesh_terms: D000328:Adult; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000276:immunology; D016022:Case-Control Studies; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D003231:Conjunctivitis / Q000276:immunology; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D017455:Receptors, IgE / Q000235:genetics*; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D012220:Rhinitis / Q000276:immunology; D012882:Skin Tests; D013030:Spain
chemical_list: D039741:Antigens, Dermatophagoides; D006023:Glycoproteins; D017455:Receptors, IgE; D019948:Receptors, Interleukin-4