Biological activities of the plant-derived bisindole voacamine with reference to malaria.
The in vivo antiplasmodial activity of voacamine was assessed in a 4-day test. It was shown to exhibit in vivo activity with 25.4% and 43.4% inhibition of parasitaemia with 2.5 and 10 mg/kg, respectively. In synchronized cultures, it was found to act on trophozoite and schizont stages of Plasmodium falciparum. Using the FMC29 strain of Plasmodium falciparum as parasite and the isobologram curve as a method to assess interaction in drug combination, it was shown to lack any chloroquine-enhancing activity and its in vitro antiplasmodial effect was not potentiated by the chemosensitizer malagashanine.
Ramanitrahasimbola
D
D
Laboratoire de Phytochimie et de Pharmacologie Cellulaire et Parasitaire, Institut Malgache de Recherches Appliquées, B. P. 3833, 101-Antananarivo, Madagascar.
Rasoanaivo
P
P
Ratsimamanga-Urverg
S
S
Federici
E
E
Palazzino
G
G
Galeffi
C
C
Nicoletti
M
M
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004357:Drug Synergism; D007050:Ibogaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D010967:Plasmodium yoelii / Q000187:drug effects*
D000470:Alkaloids; D000962:Antimalarials; C103769:malagashanine; C005891:voacamine; D007050:Ibogaine; D002738:Chloroquine