Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint.
From an oncological and immunological perspective, the T-cell-mediated induction of psoriatic plaques should be prone to malignant transformation as the phenotype of psoriatic plaques includes: chronic inflammation, epidermal hyperplasia, prolonged survival and elevated telomerase levels in lesional keratinocytes, as well as angiogenesis, exposure to carcinogens and immunosuppressants. However, conversion of a psoriatic plaque to squamous cell carcinoma is exceedingly rare. This paper explores the possible molecular mechanism for the tumor suppressor pathway in psoriatic lesions, with an emphasis on a putative senescence-switch involving p16.
Nickoloff
B J
BJ
Loyola University Medical Center, Cardinal Bernardin Cancer Center, Maywood, IL 60153, USA. bnickol@lumc.edu
D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D008954:Models, Biological; D011230:Precancerous Conditions; D011565:Psoriasis / Q000150:complications / Q000235:genetics / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*