Nitric oxide synthase in bronchial epithelium and nitric oxide metabolites in the lungs of rats with bronchial asthma after fenoterol inhalation.
Nitric oxide synthase of the bronchial epithelium and concentrations of nitric oxide metabolites (NO(2)(-)and NO(3)(-)) in bronchoalveolar lavage fluids were measured in rats with bronchial asthma after fenoterol inhalation. It was suggested that nitric oxide-ergic mechanisms can mediate the effects of inhaled beta(2)-adrenergic agonists.
Eliseeva
E V
EV
Department of Histology, Vladivostok State Medical University.
Kulakova
N V
NV
Nevzorova
V A
VA
D000280:Administration, Inhalation; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism*; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D001993:Bronchodilator Agents / Q000008:administration & dosage; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005280:Fenoterol / Q000008:administration & dosage*; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D051381:Rats
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D005280:Fenoterol; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase