title: Numerical and experimental investigation of the diffusional release of a dispersed solute from polymeric multilaminate matrices.
abstract: In the present work the release behavior of special, multilaminate matrix-type polymer systems, is studied both theoretically and experimentally. Two different mathematical models have been employed to describe the release of a dispersed solute from both single- and multilayer matrices. A parameter sensitivity study shows that the incorporation of supersaturated matrices in the formation of multilaminate devices, with a nonuniform initial solute loading, can provide a delivery system with optimized performance compared to monolithic ones. Finally, the findings of this theoretical analysis show good agreement with measurements of the release rates of a model disperse dye from both single- and multilayer matrices.
authors.affiliation: National Center for Scientific Research Demokritos, 153 10 Ag. Paraskevi Attikis, Athens, Greece.
authors.forename: G C
authors.initials: GC
authors.lastname: Charalambopoulou
authors.forename: E S
authors.initials: ES
authors.lastname: Kikkinides
authors.forename: K G
authors.initials: KG
authors.lastname: Papadokostaki
authors.forename: A K
authors.initials: AK
authors.lastname: Stubos
authors.forename: A T
authors.initials: AT
authors.lastname: Papaioannou
mesh_terms: D004058:Diffusion; D016503:Drug Delivery Systems; D008433:Mathematics; D008962:Models, Theoretical; D011108:Polymers
chemical_list: D011108:Polymers