title: Profenofos metabolites in human poisoning.
abstract: Profenofos and its metabolites were determined in a case of fatal poisoning. Little profenofos and large amounts of metabolites were detected by gas chromatography/flame photometric detection in the acid extracts of blood and urine after methylation with diazomethane. Four major metabolites containing phosphorus were identified with the synthesized metabolites, namely, despropylated profenofos, desethylated profenofos and des-S-propylated profenofos, respectively. 4-Bromo-2-chlorophenol (BCP), an aryl moiety of profenofos, was also determined in blood and urine with high performance liquid chromatograph (HPLC) as free or conjugated metabolites.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Kanazawa, 061-0293, Ishikari-Tobetsu, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: M
authors.initials: M
authors.lastname: Sakata
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Seno
authors.forename: O
authors.initials: O
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy / Q000379:methods*; D002423:Cause of Death; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D062787:Drug Overdose; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007306:Insecticides / Q000378:metabolism* / Q000506:poisoning*; D062025:Organophosphate Poisoning; D063086:Organothiophosphates / Q000378:metabolism*; D013405:Suicide
chemical_list: D007306:Insecticides; D063086:Organothiophosphates; C024273:profenofos