title: Protein kinase C inhibitors attenuate protective effect of high glucose against hypoxic injury in H9c2 cardiac cells.
abstract: In this study, we demonstrated that PKC inhibitors significantly attenuated the cardioprotective effect produced by high-glucose (22 mM) treatment for 48 h against hypoxic injury in H9c2 cardiac cells. PKC activators mimicked the cardioprotective effect of high glucose. These results suggest a possible role of PKC activation in high-glucose--induced protection.
authors.affiliation: Department of Physiology, School of Medicine, Ajou University, Suwon 442-749, Korea.
authors.forename: C H
authors.initials: CH
authors.lastname: Moon
authors.forename: Y S
authors.initials: YS
authors.lastname: Jung
authors.forename: M H
authors.initials: MH
authors.lastname: Kim
authors.forename: R M
authors.initials: RM
authors.lastname: Park
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: E J
authors.initials: EJ
authors.lastname: Baik
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects*; D002460:Cell Line; D004336:Drug Antagonism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D011493:Protein Kinase C; D005947:Glucose