title: Role of nerve growth factor in experimental autoimmune encephalomyelitis.
abstract: The expression of neural regulatory molecules by immune cells that infiltrate the nervous system upon injury may be a mechanism for cross-regulation between the nervous system and the immune system. Several lines of evidence implicate nerve growth factor (NGF) signaling through its receptors (TrkA and p75(NGFR)) as a potential source of communication between the two systems. We observed changes in NGF mRNA expression and protein secretion by T lymphocytes polarized toward the Th2 phenotype. The presence of NGF did not affect T cell proliferation or cytokine production in vitro. Mice treated with NGF by i. p. injection following induction of experimental autoimmune encephalomyelitis, an inflammatory, demyelinating disease of the central nervous system, showed a delayed onset of disease and lower clinical scores during the course of disease. These data suggest a role for NGF signaling in the regulation of the immune response, possibly by enhancing sympathetic innervation of lymphoid tissues.
authors.affiliation: Department of Neurology, University of Texas-Southwestern Medical Center, Dallas, USA.
authors.forename: L R
authors.initials: LR
authors.lastname: Arredondo
authors.forename: C
authors.initials: C
authors.lastname: Deng
authors.forename: R B
authors.initials: RB
authors.lastname: Ratts
authors.forename: A E
authors.initials: AE
authors.lastname: Lovett-Racke
authors.forename: D M
authors.initials: DM
authors.lastname: Holtzman
authors.forename: M K
authors.initials: MK
authors.lastname: Racke
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology* / Q000276:immunology; D015847:Interleukin-4 / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D020932:Nerve Growth Factor / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D016207:Cytokines; D012333:RNA, Messenger; D015847:Interleukin-4; D020932:Nerve Growth Factor