BCL10 deletions in haematological malignancies: a cloning artefact?
Mutations within the BCL10 gene, a gene involved in apoptosis, have recently been found to occur in a variety of cancers and it was suggested that BCL10 was involved in the pathogenesis of human malignancies. Our investigations of the involvement of this gene in various malignancies, however, do not uphold this suggestion. We would like to propose that, in fact, the original results were obtained as a result of a rare cloning artefact.
Duke
V
V
Haematology Department, Royal Free and University College School of Medicine, Royal Free Campus, London, UK.
Kapoor
A
A
Gricks
C
C
Melo
J
J
Foroni
L
L
D000208:Acute Disease; D048868:Adaptor Proteins, Signal Transducing; D016477:Artifacts; D000074018:B-Cell CLL-Lymphoma 10 Protein; D016022:Case-Control Studies; D003001:Cloning, Molecular; D017353:Gene Deletion; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000235:genetics; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics; D007951:Leukemia, Myeloid; D008223:Lymphoma / Q000235:genetics; D009101:Multiple Myeloma / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction
D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D009363:Neoplasm Proteins