The distribution of free sterols, polyhydroxysteroids and steroid glycosides in various body components of the starfish Patiria (=Asterina) pectinifera.
The distribution of free sterols, polyhydroxysteroids and steroid glycosides in different body components of the Far-eastern starfish Patiria (=Asterina) pectinifera has been studied. It was shown that free sterol fractions from aboral and oral body walls, gonads, stomach and pyloric ceca contained Delta(7) sterols with a preponderance of 5alpha-cholest-7-en-3beta-ol. All these body components had also toxic steroid oligoglycosides. However, polyhydroxysteroids and related low molecular weight steroid glycosides were found in stomach and pyloric ceca only. In pyloric ceca, the sulfated monoside 'asterosaponin' P(1) was identified as a main polar steroid, whereas 6-sodium sulfate of cholestane-3beta,4beta,6alpha,7alpha,8,15beta,16beta,26-octaol predominated in the stomach. Probable biological functions of polar steroids and free sterols in this starfish were discussed. It was suggested that some polyhydroxysteroids and related monoglycosides play the same biological role as bile alcohols and bile acids do in vertebrates.
Kicha
A A
AA
Laboratory of the Chemistry of Marine Natural Products, Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, 690022, Vladivostok, Russia.
Ivanchina
N V
NV
Gorshkova
I A
IA
Ponomarenko
L P
LP
Likhatskaya
G N
GN
Stonik
V A
VA
D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism; D006027:Glycosides / Q000302:isolation & purification* / Q000378:metabolism*; D006461:Hemolysis; D006914:Hydroxysteroids / Q000302:isolation & purification* / Q000378:metabolism*; D051379:Mice; D008956:Models, Chemical; D013215:Starfish / Q000378:metabolism*; D013261:Sterols / Q000096:biosynthesis* / Q000302:isolation & purification*; D013997:Time Factors; D014018:Tissue Distribution
D006027:Glycosides; D006914:Hydroxysteroids; D013261:Sterols