[Valvular regurgitation caused by anorectic agents].
Valvular heart disease associated with the use of anorectic agents is a recently described clinical entity. We report the case of a 46-year-old woman with severe regurgitation of the mitral, aortic and tricuspid valves who had been taking fenfluramine and dexfenfluramine for two years. Surgical treatment was required with replacement of three valve by mechanical prostheses. The previous history of treatment with anorectic agents, the echocardiographic morphology of the injured valves and the macroscopic and histopathologic findings strongly suggested an association between the anorectic agents and the valvular disease of the patient.
Melero Tejedor
J M
JM
Servicios de Cirugía Cardiovascular. Hospital Clínico Universitario Virgen de la Victoria. Málaga. makjom@vnet.es
Rodríguez Bailón
I
I
Such Martínez
M
M
Porras Martín
C
C
Olalla Mercadé
E
E
Espinosa Caliani
J S
JS
D001022:Aortic Valve Insufficiency / Q000139:chemically induced* / Q000601:surgery; D001067:Appetite Depressants / Q000009:adverse effects*; D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000139:chemically induced* / Q000601:surgery; D014262:Tricuspid Valve Insufficiency / Q000139:chemically induced* / Q000601:surgery
D001067:Appetite Depressants; D005277:Fenfluramine