Increase in plasma levels of oxidized low-density lipoproteins in patients with coronary spastic angina.
Oxidized low-density lipoproteins (LDL) impair endothelium-dependent dilation and constrict arteries. This study examined possible relation of the circulating plasma levels of Ox-LDL to coronary spastic angina (CSA). The plasma levels of Ox-LDL were measured by ELISA in 37 consecutive patients with CSA and normal coronary angiograms and in 79 consecutive control patients. The Ox-LDL levels in patients with CSA were significantly higher than those in controls. In multivariate analysis, higher levels of Ox-LDL were a risk factor for CSA independently of other traditional risk factors. The Ox-LDL levels had a significant and positive correlation with constrictor response of coronary arteries to the intracoronary acetylcholine infusion. Thus, Ox-LDL may play a possible role in pathogenesis of coronary spasm.
Kugiyama
K
K
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, 860-8556, Kumamoto City, Japan. kiyo@gpo.kumamoto-u.ac.jp
Sugiyama
S
S
Soejima
H
H
Kawano
H
H
Sakamoto
T
T
Takazoe
K
K
Ogawa
H
H
Doi
H
H
Yasue
H
H
D000109:Acetylcholine / Q000008:administration & dosage; D000788:Angina Pectoris, Variant / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003331:Coronary Vessels; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D012307:Risk Factors; D012720:Severity of Illness Index; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage
D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014665:Vasodilator Agents; C099252:oxidized low density lipoprotein; D002784:Cholesterol; D000109:Acetylcholine