title: Cell-cycle-dependent translational control.
abstract: Control of translation in eukaryotes occurs mainly at the initiation step. Translation rates in mammals are robust in the G1 phase of the cell cycle but are low during mitosis. These changes correlate with the activity of several canonical translation initiation factors, which is modulated during the cell cycle to regulate translation.
authors.affiliation: Department of Biochemistry and McGill Cancer Center, 3655 promenade Sir William Osler, McGill University, Montréal, H3G 1Y6, Québec, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Pyronnet
authors.forename: N
authors.initials: N
authors.lastname: Sonenberg
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D007399:Interphase; D008938:Mitosis; D010849:Picornaviridae / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D012315:RNA Caps; D015398:Signal Transduction; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
chemical_list: D012315:RNA Caps