[Study on androgen receptor mRNA expression on laryngocarcinoma tissue].
Exploring the role of androgen receptor (AR) in development of laryngocarcinoma, expression of AR in larynx squamous cell carcinoma and normal larynx tissue were observed and analysed by Northern blot hybridization. The results showed: AR mRNA was founded in both 27 larynx squamous carcinoma and 6 normal larynx tissue beside carcinoma samples. The intensity of AR mRNA expression in carcinoma was significantly stronger than that in normal larynx tissue, and the expression of AR mRNA was in low degree in normal larynx tissue. The existence and different expression of AR mRNA in both laryngocarcinoma and normal larynx tissue suggest that AR gene can control development of laryngocarcinoma tissue.
Zhu
J
J
Department of Otolaryngology-Head and Neck Surgery, Third Affiliated Hospital, Bethune Medical University, Changchun 130031.
Zhao
D
D
Li
G
G
D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011944:Receptors, Androgen / Q000096:biosynthesis* / Q000235:genetics
D012333:RNA, Messenger; D011944:Receptors, Androgen