title: New adhesion formation after laparoscopic and conventional adhesiolysis: a comparative study in the rabbit.
abstract: This study aimed to compare new adhesion formation after laparoscopic and conventional adhesiolysis. In a first operation, 24 rabbits underwent fixation of deserosated cecum (6 cm2) to the lateral abdominal wall to induce standardized adhesions. After 4 weeks, adhesiolysis was performed by laparoscopy (n = 12) or laparotomy (n = 12). Outcome was assessed by the incidence, extent, and location of adhesion reformation. After conventional adhesiolysis, new adhesions developed in all the rabbits, as compared with 75% after laparoscopic adhesiolysis. The extent of newly formed adhesions was significantly reduced (p < 0.001) after laparoscopic adhesiolysis (368+/-115 mm2) as compared with conventional adhesiolysis (2434+/-245 mm2). There were no adhesions to trocar wounds, but adhesions to the abdominal incision were found in 33% of the conventional group. In a rabbit model comparing laparoscopic and conventional adhesiolysis in a standardized experimental setting, laparoscopic adhesiolysis is associated with a significantly reduced formation of new postoperative adhesions.
authors.affiliation: Department of Surgery, Technical University, Aachen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Tittel
authors.forename: K H
authors.initials: KH
authors.lastname: Treutner
authors.forename: S
authors.initials: S
authors.lastname: Titkova
authors.forename: A
authors.initials: A
authors.lastname: Ottinger
authors.forename: V
authors.initials: V
authors.lastname: Schumpelick
mesh_terms: D000005:Abdomen; D000818:Animals; D010535:Laparoscopy; D011817:Rabbits; D011897:Random Allocation; D000267:Tissue Adhesions / Q000601:surgery*