title: [Headcase gene--proliferation or hormonal control?].
abstract: A new insertion allele of the hdc gene was isolated and described. The nucleotide sequence of the coding region had no detectable homology with genomic DNA of any other Drosophila species, except for D. mauritiana. Gene expression was found both in adult testes and ovaries and at embryonic and larval stages. This expression pattern exhibits a strong similarity to that of cell-cycle genes. In contrast to cycE (a typical cell-cycle gene), which leads to expression termination after in vivo culturing of the wing disk, hdc did not arrest expression. It is concluded that hdc is a species-specific differentiation gene, whose regulatory activity in the development of an organism differs from that of proliferation genes.
authors.affiliation: Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kozlova
authors.forename: V P
authors.initials: VP
authors.lastname: Gur'ev
authors.forename: A G
authors.initials: AG
authors.lastname: Blinov
authors.forename: L V
authors.initials: LV
authors.lastname: Omel'ianchuk
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D007301:Insect Hormones / Q000502:physiology*; D019476:Insect Proteins / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; C098014:Hdc protein, Drosophila; D007301:Insect Hormones; D019476:Insect Proteins