Analysis and characterization of an odorant receptor gene cluster in the zebrafish genome.
A 140.7-kb segment of zebrafish genomic DNA known to contain odorant receptor (OR) genes was fully sequenced to characterize more completely the organization of this gene cluster. A total of 20 OR genes were identified in this region. The most highly related genes are grouped in closest proximity to one another and in the same transcriptional orientation, indicating that a series of tandem duplications was responsible for the expansion of the OR gene family in teleost fish. Our analysis also revealed sequences that may be involved in the transcriptional regulation of OR genes within the cluster.
Dugas
J C
JC
Department of Molecular and Cell Biology, Division of Neurobiology, University of California at Berkeley, 269 Life Sciences Addition, Berkeley, California 94720-3200, USA.
Ngai
J
J
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004251:DNA Transposable Elements; D016678:Genome; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D018035:Receptors, Odorant / Q000235:genetics*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D015027:Zebrafish / Q000235:genetics*
D004251:DNA Transposable Elements; D018035:Receptors, Odorant