Interleukin 12 and autoimmune diabetes.
Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B). This finding has potential implications for the prediction of at-risk individuals and, perhaps, for the implementation of prevention strategies relevant to several autoimmune diseases.
Adorini
L
L
Roche Milano Ricerche, 20132 Milano, Italy. luciano.adorini@roche.com
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D051379:Mice; D016688:Mice, Inbred NOD; D018448:Models, Immunological
D018664:Interleukin-12