title: [Course of the progression of experimentally induced  arteriosclerotic vessel wall changes after treatment with  magnesium orotate]  .
abstract: There are some experimental and clinical results regarding blood vessel protective properties of magnesium orotate (CAS 27067-77-2) till now. The goal of the present investigation was to verify the therapeutical efficacy of magnesium orotate vs. its singular components in cholesterol fed rabbits. Besides, the blood-lipid concentrations (LDL as risk factor for atherosclerosis and HDL as negative risk factor) were analyzed in relation to pathomorphological changes in the aortic blood vessel wall. The results of our experiments in New Zealand rabbits support the assumption that orotic acid and especially magnesium orotate influence the lipid level and/or the LDL/HDL-quotient in a favorable way and that they decrease the interaction between monocytes/macrophages and the endothelium of the blood vessels. Consequently, the plaque formation will be decreased in a clinically relevant manner.
authors.affiliation: Nationalinstitut für Pathologie, Budapest, Ungarn.
authors.forename: H
authors.initials: H
authors.lastname: Jellinek
authors.forename: E
authors.initials: E
authors.lastname: Takács
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000473:pathology* / Q000517:prevention & control*; D001808:Blood Vessels / Q000473:pathology* / Q000648:ultrastructure; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004036:Diet, Atherogenic; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009963:Orotic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011817:Rabbits
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D009963:Orotic Acid; D002784:Cholesterol; C104468:magnesium orotate