title: Multiple daily fractionation radiotherapy schedules in lung cancer.
abstract: Lung cancer is the number one worldwide cancer killer, and in spite of therapeutic advances, the overall impact on survival has remained very modest. For both small and non-small-cell lung cancer, treatment trends have shifted toward combined-modality approaches, chemotherapy for the control of systemic micrometastases, and radiotherapy for intrathoracic control. However, on both counts, rates of failure remain unacceptably high, and several novel strategies are currently being explored. The use of altered fractionation, including multiple daily fractions, reflects one approach for modifying radiotherapy. The two most common approaches are hyperfractionation and acceleration, the former designed to reduce late normal tissue toxicities and the latter to counteract accelerated tumor repopulation. Recent randomized trials suggest that such approaches may result not only in lowered rates of intrathoracic failure but also in improved survival.
authors.affiliation: Department of Human Oncology, University of Wisconsin Medical School, 600 Highland Avenue, K4/310 CSC, Madison, WI 53792, USA. mehta@mail.humonc.wis.edu
authors.forename: C A
authors.initials: CA
authors.lastname: Schulz
authors.forename: P M
authors.initials: PM
authors.lastname: Harari
authors.forename: M P
authors.initials: MP
authors.lastname: Mehta
mesh_terms: D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*