Thoracic organ donor characteristics associated with successful lung procurement.
OBJECTIVE
A shortage of suitable donors is the major impediment to clinical lung transplantation. The rate of lung recovery from potential donors is lower than that for other organs. The purpose of this study was to evaluate what factors could be modified to improve the rate of cadaver lung recovery.


METHODS
We performed a retrospective review of records from all thoracic organ donors procured by the California Transplant Donor Network between 1 January 1995 and 31 May 1997 (251 donors) to determine which donor management factors were associated with an increased likelihood of successful lung procurement.


RESULTS
There were 88 lung donors (L) and 163 donors from which hearts but no lungs were procured (H). Longer time to donor network referral was associated with a reduced chance for successful lung procurement. Donor age, cause of death, and time of admission were not important factors. Most donors in this study had an acceptable A-a gradient at admission to the hospital but lung function deteriorated in group H. Corticosteroid usage and initially clear breath sounds were independent predictors of successful procurement by multivariate analysis.


CONCLUSIONS
Early contact with the donor referral network, and corticosteroids may help to improve the lung procurement rate from potential donors.
McElhinney
D B
DB
University of California San Francisco, 94143, USA.
Khan
J H
JH
Babcock
W D
WD
Hall
T S
TS
D000328:Adult; D002102:Cadaver; D002140:California; D016208:Databases, Factual; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000187:drug effects; D016040:Lung Transplantation; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D012189:Retrospective Studies; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data*
D005938:Glucocorticoids; D008776:Methylprednisolone Hemisuccinate