title: Polyunsaturated fatty acid-specific elongation enzymes.
abstract: We have isolated a novel gene (GLELO) from Mortierella alpina and its homologue (CEELO1) from Caenorhabditis elegans and demonstrate the involvement of their encoded proteins in the elongation of C(18) polyunsaturated fatty acids.
authors.affiliation: Ross Products Division, Abbott Laboratories, Columbus, OH 43215, USA.
authors.forename: T
authors.initials: T
authors.lastname: Das
authors.forename: J M
authors.initials: JM
authors.lastname: Thurmond
authors.forename: E
authors.initials: E
authors.lastname: Bobik
authors.forename: A E
authors.initials: AE
authors.lastname: Leonard
authors.forename: J M
authors.initials: JM
authors.lastname: Parker-Barnes
authors.forename: Y S
authors.initials: YS
authors.lastname: Huang
authors.forename: P
authors.initials: P
authors.lastname: Mukerji
mesh_terms: D000123:Acetyltransferases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology; D003001:Cloning, Molecular; D000081031:Fatty Acid Elongases; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D007700:Kinetics; D009090:Mucorales / Q000201:enzymology* / Q000235:genetics; D011994:Recombinant Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae; D013379:Substrate Specificity
chemical_list: D005231:Fatty Acids, Unsaturated; D011994:Recombinant Proteins; D000123:Acetyltransferases; D000081031:Fatty Acid Elongases