title: Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.
abstract: The chronological accumulation of mitochondrial dysfunction has been proposed as a potential mechanism in the physiological processes of aging. Cytochrome c oxidase deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders. We show that there is an age-related increase in cytochrome c oxidase-deficient cells in both hippocampal pyramidal neurons and choroid plexus epithelial cells. We suggest that these cells contribute to the cell death and dysfunction in CNS aging.
authors.affiliation: Department of Neurology, The Medical School, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK. d.a.cottrell@ncl.ac.uk
authors.forename: D A
authors.initials: DA
authors.lastname: Cottrell
authors.forename: E L
authors.initials: EL
authors.lastname: Blakely
authors.forename: M A
authors.initials: MA
authors.lastname: Johnson
authors.forename: P G
authors.initials: PG
authors.lastname: Ince
authors.forename: G M
authors.initials: GM
authors.lastname: Borthwick
authors.forename: D M
authors.initials: DM
authors.lastname: Turnbull
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002831:Choroid Plexus / Q000166:cytology / Q000378:metabolism*; D030401:Cytochrome-c Oxidase Deficiency; D004272:DNA, Mitochondrial / Q000235:genetics; D004847:Epithelial Cells / Q000201:enzymology; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011180:Postmortem Changes; D017966:Pyramidal Cells / Q000201:enzymology; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D004272:DNA, Mitochondrial; D013385:Succinate Dehydrogenase