Effect of resveratrol on intimal hyperplasia after endothelial denudation in an experimental rabbit model.
The ability of resveratrol to inhibit vascular intimal thickening was tested in an experimental model in which endothelial denudation was performed in the normal rabbit iliac artery. Resveratrol (2 approximately 4mg/ kg/d) was administered intragastrically for 5 weeks beginning 1 week before denudation. At the higher concentration of resveratrol, the intimal hyperplasia of injured vascular wall was effectively inhibited; the intimal proliferation index also was significantly less than that in the untreated control group (0.28 +/- 0.07 vs 0.41 +/- 0.13, respectively, p<0.01); the relative luminal area increased from 0.38 +/- 0.06 in the untreated control group to 0.53 +/- 0.10 in the resveratrol treatment group (p < 0.001); and the count of smooth muscle cells in the thickened intima was statistically significantly reduced in the high dose resveratrol treatment group than that in the untreated group (1,115 +/- 510 vs 1,796 +/- 963, respectively, p < 0.05). Resveratrol added to the culture media of cultured rabbit vascular smooth muscle cells inhibited DNA synthesis in a dose-dependent manner. These results showing that resveratrol is capable of inhibiting intimal hyperplasia of injured artery raise the possibility that this polyphenol might have clinical potential in prevention and treatment of restenosis after angioplasty.
Zou
J
J
Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, China.
Huang
Y
Y
Cao
K
K
Yang
G
G
Yin
H
H
Len
J
J
Hsieh
T C
TC
Wu
J M
JM
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002417:Cattle; D002478:Cells, Cultured; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000601:surgery; D006083:Graft Occlusion, Vascular / Q000188:drug therapy / Q000517:prevention & control*; D006965:Hyperplasia / Q000473:pathology; D007083:Iliac Artery / Q000187:drug effects / Q000601:surgery; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D011817:Rabbits; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol