title: An observational evaluation of the rate of awakening after isoflurane or desflurane used in daily clinical practice.
abstract: OBJECTIVE
  To evaluate the rate of awakening after desflurane (D) or isoflurane (I) anesthesia when used during daily clinical practice.
  
  
  METHODS
  Observational prospective study.
  
  
  METHODS
  University-affiliated metropolitan hospital.
  
  
  METHODS
  68 ASA physical status I and II patients (18-75 yrs) scheduled for abdominal surgeries.
  
  
  METHODS
  Patients scheduled for abdominal surgery of various duration received either D or I. No time was specified for discontinuation of the inhaled drugs at the end of the surgery. T0 for recovery parameters was stated as the end of the surgery. A p-value < 0.05 was considered as significant. Results are expressed as medians and ranges.
  
  
  RESULTS
  68 patients (32 in D group and 36 in I group) were analyzed. Patient demographic data were similar between the two groups. Duration of surgery was 151 minutes (83-428 min) and 174 minutes (40-552 min) for I and D, respectively. Extubation occurred earlier after D (18 min [9-35 min]) as compared to I (32 min [7-77 min]). Time to reach the Aldrete score at 10 was faster after D (30 min [12-45]) as compared to I (46 min [15-110]). Unlike I, the rate of awakening after D was independent of the duration of surgery. The differences between D and I reached statistical significance in surgical procedures lasting more than 100 minutes.
  
  
  CONCLUSIONS
  Used during routine conditions, D allows for faster recovery than I in surgical procedures lasting more than 100 minutes. The rate of awakening after D remained independent of the duration of the surgical procedure.
authors.affiliation: Department of Anesthesia and Intensive Care, Pharmacy, and Digestive Surgical Unit, St-Antoine University Hospital, Paris, France. mark.beaussier@sat.ap-hop-paris.fr
authors.forename: M
authors.initials: M
authors.lastname: Beaussier
authors.forename: A
authors.initials: A
authors.lastname: Decorps
authors.forename: P
authors.initials: P
authors.lastname: Tilleul
authors.forename: P
authors.initials: P
authors.lastname: Balladur
authors.forename: A
authors.initials: A
authors.lastname: Lienhart
mesh_terms: D000005:Abdomen / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation; D000077335:Desflurane; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D007530:Isoflurane / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D000077335:Desflurane; D007530:Isoflurane