title: Possible Role of Formaldehyde in the Apoptotic and Mitotic Effect of 1-Methyl-Ascorbigen.
abstract: PC-3 human prostate carcinoma cells were treated with 100 mg/ml 1-methyl-ascorbigen (Me-Asc). This treatment resulted in a significant decrease in tumor cell number in parallel with an increase in apoptotic cells. The formaldehyde (HCHO) level in the culture medium was also increased. Dimedone (Di), a known capture molecule forming formal-demethone with HCHO, applied simultaneously with Me-Asc in 10 mg/ml doses diminished the apoptosis-inducing effect of Me-Asc. The possible role of in situ generated HCHO in the induction of apoptosis is discussed.
authors.affiliation: Semmelweis University of Medicine, 1st Institute of Pathology and Experimental Cancer Research, Budapest, Hungary.
authors.forename: Béla
authors.initials: B
authors.lastname: Szende
authors.forename: Ernô
authors.initials: E
authors.lastname: Tyihák
authors.forename: Gyula
authors.initials: G
authors.lastname: Szókán
authors.forename: György
authors.initials: G
authors.lastname: Kátay