title: [Single nucleotide polymorphism in beta2-adrenoceptor gene and the distribution in Chinese Han ethnic group].
abstract: OBJECTIVE
  The study was conducted to investigate single nucleotide polymorphism(SNP) in beta2-adrenoceptor(beta2-AR) gene and the distribution of these identified SNPs in Chinese Han ethnic group.
  
  
  METHODS
  beta2-AR gene was sequenced to detect SNPs by fluorescent labeling automatic sequencing method in 80 unrelated samples from territory of Dabie Mountain in Anhui province.
  
  
  RESULTS
  A total of 8 SNPs were identified in length of 3.8 kb, including 5 SNPs in code region, 3 SNPs in regulatory region. Although the variations, -468C to G, -367T to C, -47C to T,-20T to C, +79C to G, +100G to A, +491C to T, +1098T to C have been identified in other ethnic groups, they have not been found in our study. The allele distribution of SNPs is in good unity with the Hardy-Weinberg equilibrium.
  
  
  CONCLUSIONS
  The distribution of SNPs in beta2-AR gene is not equable and the SNPs in different ethnic groups differ greatly. The allele distribution of SNPs conforms well to the Hardy-Weinberg equilibrium.
authors.affiliation: Institute of Genetics, Fudan University, Shanghai, 200433 P.R.China. drlu@fudan.edu.cn
authors.forename: W U
authors.initials: WU
authors.lastname: Hong
authors.forename: G
authors.initials: G
authors.lastname: Cai
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Xiao
authors.forename: D
authors.initials: D
authors.lastname: Lu
authors.forename: J
authors.initials: J
authors.lastname: Xue
authors.forename: X
authors.initials: X
authors.lastname: Qiu
authors.forename: L
authors.initials: L
authors.lastname: Jin
mesh_terms: D000483:Alleles; D002681:China / Q000208:ethnology; D006801:Humans; D006973:Hypertension / Q000235:genetics; D011110:Polymorphism, Genetic; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
chemical_list: D018343:Receptors, Adrenergic, beta-2