Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus.
The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compound mellein as the active component of the extract. Also isolated were circumdatin F and a new alkaloid, circumdatin G. The structure of circumdatin G was determined by spectroscopic analysis.
Dai
J
J
Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore.
Carté
B K
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Sidebottom
P J
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Sek Yew
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Huang
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Butler
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D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001235:Aspergillus ochraceus / Q000737:chemistry*; D005285:Fermentation; D016174:Hepacivirus / Q000187:drug effects / Q000201:enzymology; D049934:Isocoumarins; D009682:Magnetic Resonance Spectroscopy; D009793:Ochratoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D000470:Alkaloids; D000998:Antiviral Agents; D049934:Isocoumarins; D009793:Ochratoxins; D011480:Protease Inhibitors; C428194:circumdatin F; C428193:circumdatin G; C120538:ochracin