title: The effect of local recurrence on survival in resected osteosarcoma.
abstract: The aim of this study was to assess the effect of local recurrence on survival in primary osteosarcoma. 559 patients entered into two randomised trials of the European Osteosarcoma Intergroup who received surgery for primary operable high-grade osteosarcoma of the extremities were included in this analysis. Proportional hazards modelling techniques were used to assess the relative importance of sex, age, site, surgery performed and local recurrence. The last of these was considered as a time-dependent covariate. 42/559 (8%) patients had a local recurrence. In the multivariate analysis, local recurrence was found to greatly increase the risk of death (hazard ratio (HR)=5.10, 95% confidence interval (CI) 3.51-7.41). Site and surgery performed also had a significant influence within this model. Using the technique of landmark analysis, with the landmark time set at 18 months, local recurrence alone had a significant influence on survival (HR=4.60, 95% CI 2.80-7.57). Local recurrence is an indicator of poorer survival for patients with operable primary osteosarcoma.
authors.affiliation: Cancer Division, MRC Clinical Trials Unit, 222 Euston Road, NW1 2DA, London, UK. sw@ctu.mrc.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Weeden
authors.forename: R J
authors.initials: RJ
authors.lastname: Grimer
authors.forename: S R
authors.initials: SR
authors.lastname: Cannon
authors.forename: A H
authors.initials: AH
authors.lastname: Taminiau
authors.forename: B M
authors.initials: BM
authors.lastname: Uscinska
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D002648:Child; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000401:mortality* / Q000473:pathology; D012516:Osteosarcoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D016016:Proportional Hazards Models; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis