Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma.
Multiple myeloma (MM) is a B-lineage malignancy with unknown aetiology. It has been considered that predisposing genetic factors might be implicated in the disease. In this study, the microsatellite polymorphism in the exon 3 of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene was analysed in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), together with ethnically matched healthy controls. The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and MGUS compared with matched healthy controls, indicating that the CTLA-4 microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.
Zheng
C
C
Division of Haematology, Department of Medicine, Karolinska Hospital and Karolinska Institutet, Stockholm, Sweden. Chengyun.Zheng@cmm.ki.se
Huang
D
D
Liu
L
L
Björkholm
M
M
Holm
G
G
Yi
Q
Q
Sundblad
A
A
D000069594:Abatacept; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D060908:CTLA-4 Antigen; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018796:Immunoconjugates; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D010265:Paraproteinemias / Q000235:genetics; D011110:Polymorphism, Genetic; D011336:Probability
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D018796:Immunoconjugates; D000069594:Abatacept