title: Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis.
abstract: We investigated the effects of the water soluble fraction of Terminalia chebula (Combretaceae) (WFTC) on systemic and local anaphylaxis. WFTC administered 1h before compound 48/80 injection inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.01-1.0 g/kg. When WFTC was administered 5 or 10 min after compound 48/80 injection, the mortality also decreased in a dose-dependent manner. Passive cutaneous anaphylaxis was inhibited by 63.5+/-7.8% by oral administration of WFTC (1.0 g/kg). When WFTC was pretreated at concentrations ranging from 0.005 to 1.0 g/kg, the serum histamine levels were reduced in a dose-dependent manner. WFTC (0.01-1.0 mg/ml) also significantly inhibited histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. However, WFTC (1.0 mg/ml) had a significant increasing effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha production from RPMC. These results indicate that WFTC may possess a strong antianaphylactic action.
authors.affiliation: College of Pharmacy, Woosuk University, Chonju, 565-701, Chonbuk, South Korea.
authors.forename: T Y
authors.initials: TY
authors.lastname: Shin
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeong
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: J K
authors.initials: JK
authors.lastname: Lee
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: B S
authors.initials: BS
authors.lastname: Chae
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: H W
authors.initials: HW
authors.lastname: Kang
authors.forename: C M
authors.initials: CM
authors.lastname: Lee
authors.forename: K C
authors.initials: KC
authors.lastname: Lee
authors.forename: S T
authors.initials: ST
authors.lastname: Park
authors.forename: E J
authors.initials: EJ
authors.lastname: Lee
authors.forename: J P
authors.initials: JP
authors.lastname: Lim
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: Y M
authors.initials: YM
authors.lastname: Lee
mesh_terms: D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D004140:Dinitrophenols / Q000037:antagonists & inhibitors; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000276:immunology; D007202:Indicators and Reagents; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D004140:Dinitrophenols; D007202:Indicators and Reagents; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine