title: Intramedullary and spinal canal tumors in patients with neurofibromatosis 2: MR imaging findings and correlation with genotype.
abstract: OBJECTIVE
  To determine the appearance of spinal tumors on magnetic resonance (MR) images of patients with neurofibromatosis 2 (NF2), to assess the biologic behavior of these tumors, and to determine the correlation between NF2 germline mutations and these tumors.
  
  
  METHODS
  Spinal MR images in 49 patients with NF2 were reviewed retrospectively. Intramedullary and intradural extramedullary tumors were counted, and imaging features and growth patterns of intramedullary tumors were determined. Medical records were reviewed for spinal tumor surgery. Data on spinal tumors and NF2 germline mutations in 37 patients from 19 families were analyzed for genotype-phenotype correlation.
  
  
  RESULTS
  Thirty-one patients (63%) had spinal tumors: Twenty-six (53%) had intramedullary tumors, 27 (55%) had intradural extramedullary tumors, and 22 (45%) had at least one tumor of each type. Three (12%) patients with intramedullary tumors versus 16 (59%) with extramedullary tumors had undergone surgery for the respective types of tumors. Compared with patients with all other types of mutations, a higher percentage of patients with nonsense and frameshift mutations had intramedullary tumors (P <.025); these patients also had higher mean numbers of all tumors (P <.001), intramedullary tumors (P <.001), and nerve sheath tumors (NSTs) (P <.001).
  
  
  CONCLUSIONS
  In patients with NF2 and spinal tumors, extramedullary tumors (predominantly NSTs) were present in higher numbers and were associated with more surgery than were intramedullary tumors. Our data suggest that the association between nonsense and frameshift mutations and severe NF2 may extend to specific categories of spinal tumors.
authors.affiliation: Department of Diagnostic Radiology, Clinical Center, National Institutes of Health, 10 Center Dr, MSC 1182, Rm 1C660, Bethesda, MD 20892-1182, USA. npatronas@nih.gov
authors.forename: N J
authors.initials: NJ
authors.lastname: Patronas
authors.forename: N
authors.initials: N
authors.lastname: Courcoutsakis
authors.forename: C M
authors.initials: CM
authors.lastname: Bromley
authors.forename: G L
authors.initials: GL
authors.lastname: Katzman
authors.forename: M
authors.initials: M
authors.lastname: MacCollin
authors.forename: D M
authors.initials: DM
authors.lastname: Parry
mesh_terms: D000328:Adult; D018389:Codon, Nonsense; D016368:Frameshift Mutation; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D009154:Mutation; D018317:Nerve Sheath Neoplasms / Q000235:genetics* / Q000473:pathology*; D016518:Neurofibromatosis 2 / Q000235:genetics* / Q000473:pathology*; D010641:Phenotype; D012189:Retrospective Studies; D013115:Spinal Canal / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000235:genetics* / Q000473:pathology*; D013125:Spinal Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D018389:Codon, Nonsense