[Role of spermatic plasma enzyme in pathogenesis of relative male sterility].
A complex of biochemical tests and standard techniques were used in males with relative sterility (RS) for ejaculate study allowing to detect pathology by qualitative and quantitative characteristics of the activity of spermatic plasma enzymes: alkaline phosphatase, acid phosphatase, gamma-glutamyl transferase, dipeptyl aminotransferase IV. A comprehensive evaluation of spermatic plasma enzymes of membrane-bound and intrastructural location made in 602 patients helped to establish severity and pathogenetic mechanisms of spermatozoon membrane damage in male RS. Hyperenzymospermia in patients with RS was of membrane origin and could be due to destabilization of the membrane and spermatozoon intrastructural elements. Staging of and an original approach to pathogenesis of impaired fertilizing ability of spermatozoa in males with RS are proposed.
Neĭmark
A I
AI
Aliev
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RT
D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D015415:Biomarkers; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism*; D006801:Humans; D007248:Infertility, Male / Q000201:enzymology* / Q000209:etiology; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index; D013094:Spermatozoa / Q000201:enzymology*; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D015415:Biomarkers; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D018819:Dipeptidyl Peptidase 4