Serotonergic heterotypic sprouting in the unilaterally dopamine-depleted mouse neostriatum.
The effects of unilateral 6-hydroxydopamine (6-OHDA) treatment on striatal serotonin neurons in 12-day-old mice were studied using immunohistochemistry. The unilateral 6-OHDA lesions were evaluated with tyrosine hydroxylase (TH) immunohistochemistry. The majority of the TH-immunoreactive structures disappeared from the substantia nigra and neostriatum on the 6-OHDA lesioned side. However, the density of serotonin fibers was markedly increased throughout the 6-OHDA-depleted neostriatum 1 year later. These results suggest that serotonergic heterotypic sprouting may be permanent.
Yamazoe
I
I
Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan. Ichiro.Yamazoe@ma2.seikyou.ne.jp
Takeuchi
Y
Y
Matsushita
H
H
Kawano
H
H
Sawada
T
T
D000367:Age Factors; D000818:Animals; D004298:Dopamine / Q000172:deficiency*; D007150:Immunohistochemistry; D051379:Mice; D008813:Mice, Inbred ICR; D017072:Neostriatum / Q000166:cytology* / Q000378:metabolism; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism; D016501:Neurites / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology; D016627:Oxidopamine; D012701:Serotonin / Q000032:analysis / Q000502:physiology*; D013565:Sympatholytics; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D013565:Sympatholytics; D012701:Serotonin; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine