Apolipoprotein D expression in endometrial carcinomas.
BACKGROUND
Apolipoprotein D is a protein component of the human plasma lipid transport system but is also associated with a more favorable prognosis in breast cancer and ovarian cancer women. This study was undertaken to examine the tumoral expression of apolipoprotein D in endometrial cancer and to analyze the possible correlation with tumor and patients characteristics as well as androgen receptors and its prognostic significance.


METHODS
Immunohistochemical evaluation was used to examine apolipoprotein D expression in paraffin blocks from 58 endometrial carcinomas.


RESULTS
A total of twenty (34%) tumors stained positively. Staining was localized in tumor cells. No significant correlation was found between apo D expression and patients or tumor characteristics and androgen receptor status. In addition, apolipoprotein D expression was not associated with patient prognosis.


CONCLUSIONS
Apolipoprotein D is expressed by a significant percentage of endometrial carcinomas without apparent association with other clinicopathologic parameters or with outcome of patients.
Rojo
J V
JV
Department of Gynecology, Hospital de Jove, Gijón, Asturias, Spain.
González
L O
LO
Lamelas
M L
ML
Merino
A
A
Vizoso
F
F
D001053:Apolipoproteins / Q000378:metabolism*; D053399:Apolipoproteins D; D014408:Biomarkers, Tumor / Q000032:analysis*; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000401:mortality; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D011379:Prognosis; D011944:Receptors, Androgen / Q000378:metabolism
D001053:Apolipoproteins; D053399:Apolipoproteins D; D014408:Biomarkers, Tumor; D011944:Receptors, Androgen