title: Gastric tube graft interposition as an oesophageal substitute.
abstract: BACKGROUND
  Use and techniques of oesophageal replacement for long gap oesophageal atresia are still evolving. Gastric tube graft interposition as an oesophageal substitute was evaluated on an animal model.
  
  
  METHODS
  Twenty-three postweaned, 28-day-old-piglets were used as the experimental animals. Isoperistaltic gastric tube interposition based on the right gastroepiploic vessels was performed at 28 days of life. Postoperative evaluation included weekly measurement of weight, clinical assessment for gastrointestinal and respiratory complications and deglutition difficulties. Haemoglobin, serum ferritin, albumin, globulins, total proteins and red cell folate were assayed. Pigs were killed and analysed histopathologically following a maximum observation period of 149 days.
  
  
  RESULTS
  Growth of the pigs was normal. Deglutition was not impaired in 16 pigs (89%). Minor leak was diagnosed in three pigs (17%), which was successfully managed conservatively. Anastomotic stricture was seen in two pigs (11%). Graft necrosis was not seen. Gross histology showed the absence of hypertrophy, redundancy and kinking of the interposed gastric tube graft. Microscopically non-erosive oesophagitis was seen in three pigs (17%), ulcerative oesophagitis was seen in two pigs (11%) and submucosal fibrosis was seen in seven pigs (39%). Dysplasia or Barrett's oesophagitis was not observed at the end of animal growth.
  
  
  CONCLUSIONS
  Gastric tube graft interposition is an immediate ideal oesophageal substitute due to fewer complications, probable absence of gastro-oesophageal reflux in the majority by histology, and absence of dilatation and redundancy of the interpose tube. The oesophageal substitute adequately met the nutritional needs for growth and development in the animal model.
authors.affiliation: Department of Paediatric Surgery, St George's Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Samuel
authors.forename: D M
authors.initials: DM
authors.lastname: Burge
authors.forename: I E
authors.initials: IE
authors.lastname: Moore
mesh_terms: D000818:Animals; D003679:Deglutition / Q000502:physiology; D004944:Esophagoplasty / Q000379:methods*; D004947:Esophagus / Q000473:pathology; D013270:Stomach / Q000098:blood supply / Q000601:surgery*; D013552:Swine