title: Long-term mortality rates reflect progressive prognostic benefits of thrombolysis in patients with first acute myocardial infarction.
abstract: This community nonrandomized study comprised a consecutive cohort of 1,545 (81% males) < or = 65-year-old patients who survived a first acute myocardial infarction (AMI). The all-cause 4- to 5-year mortality rate was 9% (80% cardiac). Univariate analysis revealed that older age, female gender, hypertension, diabetes, not undergoing thrombolysis, higher Killip class, preinfarction heart disease, peripheral vascular disease (PVD) and chronic obstructive lung disease (COLD) were significantly associated with increased mortality. Multivariate analyses disclosed the latter five parameters as being independent predictors of mortality. Our results show that patients undergoing thrombolysis enjoyed a progressive prognostic benefit over time. The independent contribution of PVD and COLD to long-term mortality is highlighted, in addition to the contribution of thrombolytic therapy, Killip class, and heart disease prior to infarction as being important predictors of long-term mortality in patients with a first AMI.
authors.affiliation: Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Shapira
authors.forename: A
authors.initials: A
authors.lastname: Pines
authors.forename: U
authors.initials: U
authors.lastname: Goldbourt
authors.forename: Y
authors.initials: Y
authors.lastname: Villa
authors.forename: Y
authors.initials: Y
authors.lastname: Drory
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D016019:Survival Analysis; D015912:Thrombolytic Therapy