title: Selection of bioprocess simulation software for industrial applications.
abstract: Two commercially available, process-simulation software packages (Aspen Batch Plus v1.2, Aspen Technology, Inc., Cambridge, Massachusetts, and Intelligen SuperPro v3.0, INTELLIGEN, INC., Scotch Plains, Ner Jersey) are evaluated for use in modeling industrial, biotechnology processes. Software is quantitatively evaluated by Kepner-Tregoe Decision Analysis (Kepner and Tregoe, 1981). This evaluation shows that Aspen Batch Plus v1.2 (ABP) and Intelligen SuperPro v3.0 (ISP) can successfully perform specific simulation tasks but do not provide a complete model of all phenomena occurring within a biotechnology process. Software is best suited to provide a format for process management, using material and energy balances to answer scheduling questions, explore equipment change-outs, and calculate cost data. The ability of simulation software to accurately predict unit operation scale-up and optimize bioprocesses is limited. To realistically evaluate the software, a vaccine manufacturing process under development at Merck & Company is simulated. Case studies from the vaccine process are presented as examples of how ABP and ISP can be used to shed light on real-world processing issues.
authors.affiliation: Department of Chemical & Biochemical Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA.
authors.forename: T
authors.initials: T
authors.lastname: Shanklin
authors.forename: K
authors.initials: K
authors.lastname: Roper
authors.forename: P K
authors.initials: PK
authors.lastname: Yegneswaran
authors.forename: M R
authors.initials: MR
authors.lastname: Marten
mesh_terms: D001709:Biotechnology; D002498:Centrifugation; D003198:Computer Simulation; D017076:Computer-Aided Design; D004340:Drug Contamination; D008954:Models, Biological; D012984:Software; D012985:Software Design; D013996:Time and Motion Studies; D014835:Volatilization