title: Separation of nicotine metabolites by capillary zone electrophoresis and capillary zone electrophoresis/mass spectrometry.
abstract: The use of capillary zone electrophoresis (CZE) and capillary zone electrophoresis/mass spectrometry (CZE/MS) has been demonstrated, in principle, for the separation of nicotine and nicotine metabolites. The buffer system developed for separation and detection by CZE/UV was modified for use in CZE/MS analysis. Several of the metabolites are isobaric and tandem mass spectrometric (MS/MS) techniques have been used to differentiate such analytes.
authors.affiliation: Division of Chemistry, Sheffield Hallam University, Howard St., Sheffield S1 1WB, UK.
authors.forename: M E
authors.initials: ME
authors.lastname: Palmer
authors.forename: R F
authors.initials: RF
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Chambers
authors.forename: L W
authors.initials: LW
authors.lastname: Tetler
mesh_terms: D019075:Electrophoresis, Capillary / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D009538:Nicotine / Q000032:analysis* / Q000378:metabolism
chemical_list: D009538:Nicotine