title: The endoplasmic reticulum: integration of protein folding, quality control, signaling and degradation.
abstract: The endoplasmic reticulum is the entry point into the secretory pathway. To acquire a correct conformation, secretory proteins encounter the endoplasmic reticulum molecular machines of folding, quality control, signaling and disposal, which function as an integrated mechanism. The creation of such a molecular network, spatially regulated, suggests how the endoplasmic reticulum promotes the release of correctly folded secretory proteins.
authors.affiliation: Anatomy and Cell Biology, McGill University, Montreal, Quebec, H3A 2B2, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Chevet
authors.forename: P H
authors.initials: PH
authors.lastname: Cameron
authors.forename: M F
authors.initials: MF
authors.lastname: Pelletier
authors.forename: D Y
authors.initials: DY
authors.lastname: Thomas
authors.forename: J J
authors.initials: JJ
authors.lastname: Bergeron
mesh_terms: D004721:Endoplasmic Reticulum / Q000502:physiology*; D008954:Models, Biological; D017510:Protein Folding; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011506:Proteins