title: High prevalence of sleep-disordered breathing in patients with primary open-angle glaucoma.
abstract: OBJECTIVE
  Elevated intraocular pressure and systemic hemodynamic changes are main risk factors in primary open-angle glaucoma (POAG). Sleep-disordered breathing (SDB) characterized by snoring, excessive daytime sleepiness and insomnia is accompanied by large swings in blood pressure and repetitive hypoxic periods during sleep. The aim of this study was to evaluate whether there is any relationship between SDB and POAG.
  
  
  METHODS
  Consecutively, 212 outpatients with POAG and 218 outpatients without POAG were recruited. Both eyes were examined. An interviewer-administered semi-structured questionnaire was used to collect SDB-related symptoms.
  
  
  RESULTS
  After controlling for age, relative to control group, POAG patients showed a high prevalence of snoring (47.6%, p=0.04), snoring plus, excessive daytime sleepiness (27.3%, p=0.01) and snoring plus, excessive daytime sleepiness, plus insomnia (14.6%, p=0.01).
  
  
  CONCLUSIONS
  We found a high prevalence of SDB in patients with POAG. Chronic hemodynamic changes and recurrent severe hypoxia resulting from SDB may contribute to anoxic optic nerve damage, implicated in glaucoma.
authors.affiliation: Clinique du Sommeil, CHRU de Lille, France. Hakki.Onen@u-clermont1.fr
authors.forename: S H
authors.initials: SH
authors.lastname: Onen
authors.forename: F
authors.initials: F
authors.lastname: Mouriaux
authors.forename: L
authors.initials: L
authors.lastname: Berramdane
authors.forename: J C
authors.initials: JC
authors.lastname: Dascotte
authors.forename: J F
authors.initials: JF
authors.lastname: Kulik
authors.forename: J F
authors.initials: JF
authors.lastname: Rouland
mesh_terms: D000368:Aged; D001794:Blood Pressure; D005260:Female; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D015995:Prevalence; D012891:Sleep Apnea Syndromes / Q000453:epidemiology / Q000209:etiology*; D011795:Surveys and Questionnaires