Resistance to melanoma metastases in mice selected for high acute inflammatory response.
The role of innate immunity in natural resistance to tumor progression was investigated in two mouse lines, AIRmax and AIRmin, selected by bi-directional selective breeding on the basis of high or low acute inflammatory response. Compared with AIRmin, AIRmax mice were shown to be resistant to 7,12-dimethylbenz[a]anthracene (DMBA)/12-O:-tetradecanoylphorbol-13-acetate-induced skin cancers and here we demonstrate that AIRmax are also able to restrain the development of metastases upon transfer of MHC compatible, incompatible or xenogeneic melanomas. An acute inflammatory response to melanoma cells was observed in AIRmax mice only, although both lines were found to mount similar specific immune responses to melanoma antigens. The genetically selected lines therefore represent a model system to analyze the positive correlation between multiple resistance to tumorigenesis and host inflammatory responsiveness.
Maria
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DA
Laboratório de Imunogenética, Instituto Butantan, Avenida Vital Brazil 1500, CEP 05503-900, São Paulo, SP, Brazil and Laboratoire d'Immunodifferenciation, Université Paris 7, Paris, France.
Ribeiro
O G
OG
Pizzocaro
K F
KF
De Franco
M
M
Cabrera
W K
WK
Starobinas
N
N
Gallois
V
V
Siqueira
M
M
Seman
M
M
Ibañez
O M
OM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000912:Antibodies, Neoplasm / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000276:immunology; D001241:Aspirin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D004797:Enzyme-Linked Immunosorbent Assay; D020022:Genetic Predisposition to Disease; D008545:Melanoma / Q000276:immunology / Q000556:secondary*; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008817:Mice, Mutant Strains; D015166:Monitoring, Immunologic; D009368:Neoplasm Transplantation / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology / Q000556:secondary*; D013449:Sulfonamides / Q000494:pharmacology; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D013449:Sulfonamides; D001241:Aspirin; C012655:nimesulide