title: [Development of the human monoclonal antibodies]
abstract: This article describes the current state of the development of human monoclonal antibodies. The last three years brought a wealth of new techniques and it seems that the long-awaited breakthrough of these "magic" therapeutic agents is close. This paper discusses both the classical cell-biological methods (e.g. fusion with other lymphoma cells and/or Epstein Barr virus transformation of human B-cells) and the "newc gene-technology approaches. The therapeutic possibilities of human monoclonal antibodies against infectious agents and cancer related antigens and their impact are reviewed and the development strategies - both "classical" and "new" - are discussed. The in vitro immunization technique is critically reviewed.
authors.affiliation: Institut für angewandte Zellkultur, D-München.
authors.forename: Toni
authors.initials: T
authors.lastname: Lindl