Recent developments in weekly paclitaxel therapy in lung cancer.
Paclitaxel has undergone a remarkable evolution of schedule and dosage based on observed schedule-dependent toxicity and consequent improvement of therapeutic index. A weekly schedule of administration was originally developed to exploit opportunities for radiation synergy and was subsequently explored without radiation to evaluate the potential for reduced toxicity. Three weekly schedules have emerged: paclitaxel 50 mg/m(2)/wk with concurrent radiation, paclitaxel 80 to 90 mg/m(2)/wk as a dose-dense schedule without radiation, and paclitaxel 150 to 175 mg/m(2)/wk as a dose-intensive schedule. The efficacy of these schedules, their integration as combination treatment with chemotherapy and nonchemotherapeutic agents, and their role are the subjects of substantial investigation.
Akerley
W
W
Center for Cancer and Blood Disorders, Boston University Medical Center, 88 East Newton Avenue, Boston, MA 02115, USA. wallace.akerley@bmc.org
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D019583:Dose Fractionation, Radiation; D004334:Drug Administration Schedule; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D017239:Paclitaxel / Q000008:administration & dosage* / Q000627:therapeutic use; D011379:Prognosis
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel