title: Successful lysis of an obstructive aortic and renal artery thrombus in a neonate on extracorporeal membrane oxygenation.
abstract: We describe a neonate on venoarterial extracorporeal membrane oxygenation (ECMO) with acute renal failure associated with extensive aortic and bilateral renal artery thrombosis. Concurrent anticoagulation and continuous systemic thrombolytic therapy with tissue plasminogen activator (t-PA) resulted in complete thrombolysis as evaluated by Doppler flow. The relative risk and benefits of thrombolytic therapy in heparinized patients undergoing ECMO needs to be further studied.
authors.affiliation: Department of Pediatrics, Children's Hospital of Buffalo and State University of New York at Buffalo, 219 Bryant Street, Buffalo, NY 14222-2099, USA.
authors.forename: B
authors.initials: B
authors.lastname: Gunnarsson
authors.forename: C M
authors.initials: CM
authors.lastname: Heard
authors.forename: D J
authors.initials: DJ
authors.lastname: Martin
authors.forename: M L
authors.initials: ML
authors.lastname: Brecher
authors.forename: R H
authors.initials: RH
authors.lastname: Steinhorn
mesh_terms: D001018:Aortic Diseases / Q000188:drug therapy*; D015199:Extracorporeal Membrane Oxygenation; D017809:Fatal Outcome; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D012077:Renal Artery; D012078:Renal Artery Obstruction / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator