Chloride channels in the loop of Henle.
Cl- transport in the loop of Henle is responsible for reclamation of 25-40% of the filtered NaCl load and for the formation of dilute urine. Our understanding of the physiologic and molecular mechanisms responsible for Cl- reabsorption in both the thin ascending limb and thick ascending limb of Henle's loop has increased greatly over the last decade. Plasma membrane Cl- channels are known to play an integral role in transcellular Cl- transport in both the thin and thick ascending limbs. This review focuses on the functional characteristics and molecular identities of these Cl- channels, as well as the role of these channels in the pathophysiology of disease.
Reeves
W B
WB
Division of Nephrology, University of Arkansas College of Medicine and the John L McClellan Veterans Hospital, Little Rock, Arkansas 72205, USA. WReeves@psu.edu
Winters
C J
CJ
Andreoli
T E
TE
D000595:Amino Acid Sequence; D000818:Animals; D001477:Bartter Syndrome / Q000235:genetics / Q000378:metabolism; D018118:Chloride Channels / Q000235:genetics* / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D008138:Loop of Henle / Q000378:metabolism*; D008969:Molecular Sequence Data
C086321:CLC-1 channel; D018118:Chloride Channels; D002712:Chlorides