title: A study to assess the plaque inhibitory action of a new zinc citrate toothpaste formulation.
abstract: OBJECTIVE
  Zinc-citrate-containing toothpastes have previously been suggested to be of value at inhibiting plaque and gingival inflammation. Present formulations have included triclosan which is thought to contribute major antibacterial/antiplaque effects. Alternative antimicrobial agents and other ingredients such as oils could help to produce equally effective formulations. The aim of this study was to determine whether zinc citrate toothpastes containing bromochlorophene and a triglyceride oil (1% and 8%) could inhibit de novo plaque formation.
  
  
  METHODS
  Toothpaste slurry rinses were used over a 96-h period by 24 volunteers, whilst omitting all other oral hygiene procedures. For comparative purposes, a conventional commercial fluoride control toothpaste was also used in this triple cross-over double blind study.
  
  
  RESULTS
  After 24 and 48 h, there were no statistically significant differences in plaque between the 2 test pastes and the control paste, whether assessed using a plaque index or plaque area. After 96 h, however, a significant reduction in plaque score of 10.6% and 24.2%) in plaque area (both p < 0.001) was found for the zinc citrate/1% oil toothpaste compared to the control paste. In addition, at 96 h, the 8% oil toothpaste significantly reduced plaque score compared to the control paste by 4.3% (p = 0.029).
  
  
  CONCLUSIONS
  These findings would appear to warrant further investigation into the potential value of the zinc citrate/bromochlorophene/triglyceride formulation at inhibiting both plaque and gingival inflammation.
authors.affiliation: Department of Oral & Dental Science, University of Bristol, UK.
authors.forename: J
authors.initials: J
authors.lastname: Moran
authors.forename: M
authors.initials: M
authors.lastname: Addy
authors.forename: D
authors.initials: D
authors.lastname: Corry
authors.forename: R G
authors.initials: RG
authors.lastname: Newcombe
authors.forename: J
authors.initials: J
authors.lastname: Haywood
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002733:Chlorophenols / Q000627:therapeutic use; D002951:Citrates; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009821:Oils / Q000627:therapeutic use; D014100:Toothpastes / Q000737:chemistry* / Q000627:therapeutic use*; D014280:Triglycerides / Q000008:administration & dosage; D017967:Zinc Compounds / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D002733:Chlorophenols; D002951:Citrates; D009821:Oils; D014100:Toothpastes; D014280:Triglycerides; D017967:Zinc Compounds; C013422:bromochlorophen