Modern methods for diagnosis and monitoring of nephrotoxicity during antitumor therapy with platinum derivatives.
Chemotherapy is an important method of antitumor therapy. Nephrotoxicity characteristic of many cytostatics, including platinum compounds, is a serious complication limiting the drug dose [4,5,7-9]. Platinum derivatives, in particular, cisplatin, are drugs of choice in the treatment of the majority of solid tumors. However, cisplatin induces a dose-dependent toxic damage to the kidneys [5,7,8,10].
Lyubimova
N V
NV
N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
Topchieva
S V
SV
Averinova
S G
SG
Kashkadaeva
A V
AV
Gorbunova
V A
VA
Shiryaev
S V
SV
Kushlinskii
N E
NE
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
D000970:Antineoplastic Agents; D002945:Cisplatin