title: Gastric MALT lymphoma. A clinico-pathological study of 65 cases. Relationship to Helicobacter pylori.
abstract: We report 65 cases of MALT gastric lymphomas. HP was looked for with Giemsa and Whartin Starry stains. Immunohistochemistry was done with PAP method. Anti-HP treatment was used in 9 cases. 38 were of low grade of malignancy, 23 were high grade, 4 were high grade with a low grade component. The mean age was 51.5 years, the sex ratio 1.5. Epigastric pain was the most frequent feature (87.7% of cases). Endoscopically, low grade lymphomas presented as unique or multiple ulcerations (55.3% of cases) with antral localisation (52.6% of cases). 60% of our patients were stage IE, of which 61% had low grade lymphoma, 18% were at stage II2E, 10% at stage III and 10% at stage IV. From 23 operated patients, 29% had early lymphoma which was low grade malignant in 71.5% of cases, and 71% had lymphomas which were widely spread beyond the submucosa. HP was found in 63% of cases. Histologic regression of two early lymphomas of low grade malignancy was achieved after HP eradication.
authors.affiliation: Department of Pathology, Rabta Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Ben Rejeb
authors.forename: N
authors.initials: N
authors.lastname: Kchir
authors.forename: M R
authors.initials: MR
authors.lastname: Bouali
authors.forename: N
authors.initials: N
authors.lastname: Ebdelli
authors.forename: R
authors.initials: R
authors.lastname: Fsili
authors.forename: F
authors.initials: F
authors.lastname: Khediri
authors.forename: F
authors.initials: F
authors.lastname: Ben Ayedó
authors.forename: M M
authors.initials: MM
authors.lastname: Zitouna
authors.forename: N
authors.initials: N
authors.lastname: Ben Mami
authors.forename: M
authors.initials: M
authors.lastname: Kacem
authors.forename: A
authors.initials: A
authors.lastname: Filali
authors.forename: A
authors.initials: A
authors.lastname: Ben Ammar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D005743:Gastrectomy; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D018442:Lymphoma, B-Cell, Marginal Zone / Q000382:microbiology* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000382:microbiology* / Q000473:pathology* / Q000601:surgery