Vascular effects of HMG CoA-reductase inhibitors (statins) unrelated to cholesterol lowering: new concepts for cardiovascular disease.
Lefer
A M
AM
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA. allan.m.lefer@mail.tju.edu
Scalia
R
R
Lefer
D J
DJ
D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D003331:Coronary Vessels; D019332:Endothelin-1 / Q000096:biosynthesis; D016232:Endothelins / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008148:Lovastatin / Q000627:therapeutic use*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D020556:Neutrophil Infiltration / Q000187:drug effects; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III; D011498:Protein Precursors / Q000096:biosynthesis; D019821:Simvastatin / Q000627:therapeutic use
D019332:Endothelin-1; D016232:Endothelins; D005343:Fibrinolytic Agents; D016166:Free Radical Scavengers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011498:Protein Precursors; D009569:Nitric Oxide; D008148:Lovastatin; D019821:Simvastatin; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III