title: [Hypertension and primary hyperaldosteronism].
abstract: Hypokalaemic hypertension or resistant hypertension justify investigation for primary hyperaldosteronism. The first step of this investigation is to exclude the ingestion of liquorice, alkalis and diuretics. The second is to make sure that the treatment is compatible with the hormonal tests and that the natriuresis and kaliuresis are normal. The diagnosis then depends on an increased plasma or urinary concentration of aldosterone with a low plasma renin activity. The adenoma of Conn is present in 2/3 of cases and surgically curable, and should be distinguished from adrenal hyperplasia which is treatable with distal diuretics. This is a diagnosis which requires computerised tomography or, when inconclusive, demonstration of unilateral secretion of aldosterone. Adrenalectomy, usually by coelioscopy, is indicated in Conn's adenoma when the patient is young and the hypertension severe or recent. Surgical abstention is strongly advised in cases of adrenal hyperplasia.
authors.affiliation: Service d'hypertension artérielle, hôpital Européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris.
authors.forename: P F
authors.initials: PF
authors.lastname: Plouin
authors.forename: B
authors.initials: B
authors.lastname: Fiquet-Kempf
authors.forename: F
authors.initials: F
authors.lastname: Fakhoudi
authors.forename: J P
authors.initials: JP
authors.lastname: Rezolle
authors.forename: B
authors.initials: B
authors.lastname: Guéry
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D000307:Adrenal Gland Diseases / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D000328:Adult; D000367:Age Factors; D000368:Aged; D003937:Diagnosis, Differential; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D012083:Renin / Q000378:metabolism
chemical_list: D012083:Renin