title: Impact of oncogenes and tumor suppressor genes on deregulation of hemostasis and angiogenesis in cancer.
abstract: We postulate that oncogenes and tumor suppressor genes may influence tumor angiogenesis not only directly (e.g. by upregulating vascular endothelial growth factor) but also through their impact on expression (and/or function) of tissue factor and other elements of the hemostatic system.
authors.affiliation: Hamilton Civic Hospital Research Centre, McMaster University, Hamilton, Ontario, Canada. jrak@thrombasis.hhscr.org
authors.forename: J
authors.initials: J
authors.lastname: Rak
authors.forename: G
authors.initials: G
authors.lastname: Klement
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006487:Hemostasis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000098:blood supply / Q000235:genetics*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000503:physiopathology*; D009857:Oncogenes