The non-mevalonate isoprenoid biosynthesis of plants as a test system for drugs against malaria and pathogenic bacteria.
Two plant test systems are presented in the search for new inhibitors of the non-mevalonate isoprenoid pathway. A derivative of clomazone appears to be an inhibitor of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate (DOXP/MEP) pathway of isoprenoid formation.
Zeidler
J
J
Botanical Institute II, University of Karlsruhe, Kaiserstr. 12, D-76128 Karlsruhe, Germany.
Schwender
J
J
Mueller
C
C
Lichtenthaler
H K
HK
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002070:Butadienes / Q000378:metabolism*; D002338:Carotenoids / Q000096:biosynthesis*; D002734:Chlorophyll / Q000096:biosynthesis*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D045782:Hemiterpenes; D006540:Herbicides / Q000494:pharmacology; D001467:Hordeum / Q000187:drug effects / Q000378:metabolism; D007555:Isoxazoles / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology; D010420:Pentanes; D018515:Plant Leaves / Q000502:physiology; D010944:Plants / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D002070:Butadienes; D045782:Hemiterpenes; D006540:Herbicides; D007555:Isoxazoles; D023303:Oxazolidinones; D010420:Pentanes; C005059:isoprene; D002734:Chlorophyll; D002338:Carotenoids; C095255:clomazone