Peculiarities of cholinergic regulation of smooth muscles in rabbit pulmonary arteries.
Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-induced relaxation was suppressed by denudation or nitric oxide synthase blocker L-NAME.
Kapilevich
L V
LV
Siberian Medical University, Tomsk.
Anfinogenova
Y D
YD
Baskakov
M B
MB
Kovalev
I V
IV
Nosarev
A V
AV
Medvedev
M A
MA
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D018721:Muscarinic Agonists / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010862:Pilocarpine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects
D004791:Enzyme Inhibitors; D018721:Muscarinic Agonists; D011950:Receptors, Cholinergic; D010862:Pilocarpine; D001285:Atropine; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester