title: Acute measles gastric infection.
abstract: We describe the case of a 44-year-old man who was referred for gastroscopy because of abdominal pain. During endoscopy, inflammatory changes of the antrum and corpus mucosa were clearly visible, and biopsy samples from the antrum and corpus mucosa were taken. At histology, routine hematoxylin and eosin staining showed characteristics indicative of so-called ex-Helicobacter pylori-gastritis that had developed after antibiotic treatment 2 years ago. Additional large, bizarre inclusion bodies and clusters of multinucleated giant cells were located in the surface epithelium and within the lamina propria. These giant cells had an appearance similar to that of Warthin-Finkeldey cells, which can be found during the prodromal phase of measles infection. Anti-measles virus immunochemistry showed a strong positivity for measles virus antigen within the giant cells. Based on these results, the final diagnosis of morbilliform gastritis was made. To our knowledge, no case of measles gastritis has been described in the literature. Our case report confirms the systemic character of measles virus infection and confirms that measles viral replication can involve the gastric mucosa in addition to the conjunctiva, lung, and intestina.
authors.affiliation: Institut für Pathologie, Klinikum Bayreuth, Germany. vieth.lkpathol@uni-bayreuth.de
authors.forename: M
authors.initials: M
authors.lastname: Vieth
authors.forename: K
authors.initials: K
authors.lastname: Dirshmid
authors.forename: U
authors.initials: U
authors.lastname: Oehler
authors.forename: B
authors.initials: B
authors.lastname: Helpap
authors.forename: A G
authors.initials: AG
authors.lastname: von Luckner
authors.forename: M
authors.initials: M
authors.lastname: Stolte
mesh_terms: D000208:Acute Disease; D000328:Adult; D005753:Gastric Mucosa / Q000473:pathology / Q000821:virology; D005756:Gastritis / Q000473:pathology* / Q000821:virology; D015726:Giant Cells / Q000473:pathology / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008457:Measles / Q000150:complications / Q000473:pathology*; D018103:Morbillivirus / Q000254:growth & development / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D011706:Pyloric Antrum / Q000473:pathology / Q000821:virology; D014779:Virus Replication
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M