title: The secretion of parotid saliva as stimulated by 10% citric acid is not related to precipitating factors in burning mouth syndrome.
abstract: Burning mouth syndrome (BMS) is known to have multiple precipitating factors and exists in various clinical subtypes. If salivary gland function was compromised in BMS it could help explain the link with diverse precipitating factors. This study quantified stimulated right and left parotid flow rates (SPFR) in 114 patients with BMS. It also attempted to correlate SPFR with haematinic parameters, oral candidal carriage, concurrent drug therapy and BMS subtype. No relationship was found between haematinic parameters and SPFR nor between SPFR and oral candidal carriage. Patients with Type 2 BMS had a significant reduction in SPFR. Antidepressant medication was associated with reduced SPFR but there was no such association with either tranquillisers or hypnotics. These results provide evidence of reduced parotid gland function in Type 2 BMS and a role for antidepressant medication in reducing SPFR.
authors.affiliation: Department of Oral Surgery, Oral Medicine and Oral Pathology, The Queen's University of Belfast, The Royal Victoria Hospital, Northern Ireland.
authors.forename: P J
authors.initials: PJ
authors.lastname: Lamey
authors.forename: B M
authors.initials: BM
authors.lastname: Murray
authors.forename: S A
authors.initials: SA
authors.lastname: Eddie
authors.forename: R E
authors.initials: RE
authors.lastname: Freeman
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D001774:Blood Chemical Analysis; D002054:Burning Mouth Syndrome / Q000097:blood / Q000145:classification / Q000503:physiopathology*; D002180:Candidiasis, Oral / Q000175:diagnosis; D016009:Chi-Square Distribution; D019343:Citric Acid / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D000090463:Iron Deficiencies; D010306:Parotid Gland / Q000187:drug effects* / Q000378:metabolism; D012463:Saliva / Q000187:drug effects* / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D014149:Tranquilizing Agents / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D006993:Hypnotics and Sedatives; D014149:Tranquilizing Agents; D019343:Citric Acid