title: Is there a relationship between muscle fatigue resistance and cardiovascular responses to isometric exercise in mild chronic heart failure?
abstract: BACKGROUND
  Exercise intolerance in chronic heart failure (CHF) may be due to altered fatigue resistance and muscle afferent input to the cardiovascular system from dysfunctional skeletal muscle.
  
  
  OBJECTIVE
  To determine whether calf muscle fatigue resistance was associated with the magnitude of a muscle afferent driven cardiovascular response to isometric exercise.
  
  
  RESULTS
  Cardiovascular responses were recorded in eight stable CHF patients (ejection fraction 20-40%) and nine healthy, age-matched controls during voluntary and electrically evoked isometric plantar flexion and post-exercise circulatory occlusion. The force developed by the plantar flexors during a 2-min submaximal electrically evoked fatigue test was measured. There was no relationship between ischaemic muscle fatigue and cardiovascular changes during and after voluntary contraction in either group nor evoked contraction in the CHF group. In the control group, the change in diastolic blood pressure (DBP) at the end of evoked contraction was related to the severity of fatigue at 90 s and 120 s (FI=0.01DeltaDBP+0.3, r=0.81, P<0.05 and FI=0.02DeltaDBP+0.8, r=0.84, P<0.01, respectively).
  
  
  CONCLUSIONS
  Muscle fatigue resistance did not relate to the magnitude of the cardiovascular stress generated by isometric exercise of the same muscle in these patients.
authors.affiliation: School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham, UK. c.a.carrington@bham.ac.uk
authors.forename: C A
authors.initials: CA
authors.lastname: Carrington
authors.forename: W J
authors.initials: WJ
authors.lastname: Fisher
authors.forename: M K
authors.initials: MK
authors.lastname: Davies
authors.forename: M J
authors.initials: MJ
authors.lastname: White
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D002908:Chronic Disease; D015444:Exercise / Q000502:physiology*; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D007866:Leg / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D018709:Statistics, Nonparametric