[Distribution of beta-thalassemia CD17 mutant(A-->T) in Shanxi, Gansu and Xinjiang along the "Silk Road"].
OBJECTIVE
To explore the distribution of beta-thalassemia CD17 mutant along the "Silk Road".


METHODS
Polymerase chain reaction in combination with dot-blot hybridization of allele-specific oligonucleotide probes(PCR/ASO) was used.


RESULTS
Twenty-four cases of beta-thalassemia with CD17 mutant(A-->T) including 3 cases in Shanxi, 20 cases in Gansu and 1 in Xinjiang, were found among 85 probands of beta-thalassemia.


CONCLUSIONS
According to distribution characteristics of beta-thalassemia CD17 along the "Silk Road" of China, the CD17 mutant of beta-thalassemia might probably originate from the "Silk Road" in Longxi district of Gansu.
Zhang
Y
Y
Laboratory of Medical Genetics, Urumqi General Hospital of Lanzhou Military Region, PLA, Urumqi 830000.
Yu
W
W
Li
H
H
D000293:Adolescent; D000328:Adult; D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People; D002648:Child; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D017086:beta-Thalassemia / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
D015703:Antigens, CD