title: Radiotherapy with concurrent chemotherapy for vulvar adenocarcinoma associated with extramammary Paget's disease.
abstract: BACKGROUND
  There have been no reports of the efficacy of primary radiotherapy with concurrent chemotherapy for vulvar adenocarcinoma associated with extramammary Paget's disease. In this report we discuss the differential diagnosis and efficacy of treatment for this rare tumor.
  
  
  METHODS
  The patient was diagnosed as having vulvar carcinoma stage IVb. A dose of 40 Gy in 20 fractions was administered to the vulva, including the tumor mass, and the inguinal-femoral lymph nodes with concurrent systemic chemotherapy. Outside the radiated field, bone scintigraphy showed an increase in abnormal uptake images. However, in the radiated field, the tumors disappeared macroscopically, and bone scintigraphy also showed a disappearance of the abnormal uptake images.
  
  
  CONCLUSIONS
  Within the radiated field, the efficacy was brought about by either radiotherapy only or by radiotherapy together with the sensitizing effects of chemotherapy. As for the chemotherapy itself, it was not effective in this case.
authors.affiliation: Department of Obstetrics and Gynecology, Department of Radiology, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-Ku, Sapporo 060-8638, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: N
authors.initials: N
authors.lastname: Sakuragi
authors.forename: H
authors.initials: H
authors.lastname: Shirato
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: S
authors.initials: S
authors.lastname: Fujimoto
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D000368:Aged; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D010145:Paget Disease, Extramammary / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000532:radiotherapy*