Corrective effect of clotrimazole and beta-ionol during exposure to thiophenol.
Toxic effect of thiophenol on rats can be prevented by injection of antioxidant beta-ionol and clotrimazole, an inductor of phase I and II detoxication enzymes. Both agents increase o-demethylase activity of cytochrome P-450, but do not prevent inhibition of its water-soluble form, and activate cytosol and microsomal glutathione-dependent enzymes. Both agents protected erythrocytes from peroxide damage by thiophenol and simultaneously enhanced its prooxidant effect in the liver.
Dadali
V A
VA
I. I. Metchnikov St. Petersburg State Medical Academy, Russia.
Golovanova
N E
NE
Pavlova
R N
RN
Dzhangulova
N E
NE
Vinogradova
V E
VE
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003022:Clotrimazole / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction; D004910:Erythrocyte Membrane / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D045792:Norisoprenoids; D010636:Phenols / Q000494:pharmacology*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013729:Terpenes / Q000494:pharmacology*
D000975:Antioxidants; D005609:Free Radicals; D006454:Hemoglobins; D045792:Norisoprenoids; D010636:Phenols; D013438:Sulfhydryl Compounds; D013729:Terpenes; D002084:Butylated Hydroxytoluene; C042983:thiophenol; D003577:Cytochrome P-450 Enzyme System; C008157:beta-ionone; D002374:Catalase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D003022:Clotrimazole