Multiple RNA-protein interactions in Drosophila dosage compensation.
From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved. Recent molecular genetic and biochemical studies have provided new insights into how regulatory factors in Drosophila are recruited and assembled on the X chromosome, leading to the essential hypertranscription of its genes.
Amrein
H
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Department of Genetics, Duke University Medical Center, Research Drive, Durham, NC 27710, USA. hoa1@duke.edu
D000818:Animals; D004303:Dosage Compensation, Genetic; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D012313:RNA / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D014960:X Chromosome / Q000235:genetics
D019476:Insect Proteins; D012313:RNA