title: Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model.
abstract: The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr--Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr--Abl upregulation of glucose transport was mediated by phosphatidylinositol-3-kinase. The observation that Bcr--Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.
authors.affiliation: School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK. Johanne.Bentley@ncl.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Bentley
authors.forename: I
authors.initials: I
authors.lastname: Walker
authors.forename: E
authors.initials: E
authors.lastname: McIntosh
authors.forename: A D
authors.initials: AD
authors.lastname: Whetton
authors.forename: P J
authors.initials: PJ
authors.lastname: Owen-Lynch
authors.forename: S A
authors.initials: SA
authors.lastname: Baldwin
mesh_terms: D001692:Biological Transport; D016923:Cell Death; D002460:Cell Line; D003847:Deoxyglucose / Q000378:metabolism*; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism
chemical_list: D003847:Deoxyglucose; D019869:Phosphatidylinositol 3-Kinases; D016044:Fusion Proteins, bcr-abl