Updated pathophysiologic concepts in unstable coronary artery disease.
BACKGROUND
The clinical syndrome of unstable angina has multiple causes; different therapies therefore may be indicated in different patients.


METHODS
Recent publications on unstable coronary artery disease were reviewed to identify pathophysiologic phenomena and concepts that can aid decision-making in the clinical management of patients with unstable coronary artery disease of different causes.


RESULTS
The fate of any coronary plaque depends on local and systemic factors. Autopsy studies have revealed that plaques most likely to rupture are those with a soft lipid core covered by a thin fibrous cap that may be inflamed. Systemic factors such as hypertension may be maximally expressed at the site of plaques that are prone to rupture. If an unstable plaque is identified, local therapy, such as angioplasty, stents, or radiation, and aggressive systemic therapy, such as lipid lowering, diabetes control, and hypertension control, can be used.


CONCLUSIONS
Specific therapy for acute symptoms can be used if the specific cause of the unstable state can be identified. Failure of the plaque to stabilize may result in recurrent ischemia, biochemical evidence for myocardial damage, and evidence of an inflammatory process. These factors influence prognosis; cardiac events occur more commonly when they are present.
Conti
C R
CR
School of Medicine, University of Florida, Gainesville 32610, USA.
D000789:Angina, Unstable / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D000818:Animals; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control; D003331:Coronary Vessels / Q000473:pathology; D003657:Decision Making; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D009204:Myocardial Revascularization / Q000379:methods; D011379:Prognosis; D012720:Severity of Illness Index; D015912:Thrombolytic Therapy / Q000379:methods
D000960:Hypolipidemic Agents