[Chemokines].
Chemokines are a group of approximately 50 small peptides that are potent activators and chemoattractants of leucocytes. Except of their role in inflammation they are involved also in other biological activities as angiogenesis, hematopoesis, and enhancing the host response to tumors. The chemokine family is divided according to their different biochemical structure and biological activities into 4 subfamilies--C, CC, CXC, and CX3C. Activities of chemokines are mediated by a family of 7-transmembrane G-protein-coupled receptors. Chemokine receptors have been implicated in several disease states, esp. in allergy and malaria. However, the most fascinating was discovery that some of them serve as coreceptors for human immunodeficiency virus type 1. (Tab. 2, Fig. 1, Ref. 38.)
Buc
M
M
Department of Immunology, Faculty of Medicine, Comenius University, Bratislava. buc@fmed.uniba.sk
Bucova
M
M
D000818:Animals; D018925:Chemokines / Q000502:physiology*; D006801:Humans; D019707:Receptors, Chemokine / Q000502:physiology
D018925:Chemokines; D019707:Receptors, Chemokine