title: Protein design based on folding models.
abstract: The basic rules governing the folding of small, single-domain proteins are being discovered. New algorithms that can predict the major features of the folding process give the opportunity to design and optimise protein folding in a rational way. Recent experimental works suggest that sequence-specific features should be integrated in folding models to improve their performance.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg D-69117, Germany. guerois@embl-heidelberg.de
authors.forename: R
authors.initials: R
authors.lastname: Guerois
authors.forename: L
authors.initials: L
authors.lastname: Serrano
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D008956:Models, Chemical; D008958:Models, Molecular; D015202:Protein Engineering / Q000379:methods*; D017510:Protein Folding