No beneficial effect of interferon-gamma treatment in 2 human immunodeficiency virus-infected patients with Mycobacterium avium complex infection.
Two human immunodeficiency virus-infected patients with refractory disseminated Mycobacterium avium complex infection were treated with recombinant interferon-gamma (IFN-gamma) given subcutaneously for 3 and 4 months, respectively. Although both patients demonstrated some clinical improvement initially, IFN-gamma therapy did not produce sustained benefit.
Lauw
F N
FN
Department of Infectious Diseases, Tropical Medicine, and AIDS, Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands.
van Der Meer
J T
JT
de Metz
J
J
Danner
S A
SA
van Der Poll
T
T
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology; D000328:Adult; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
D007371:Interferon-gamma