title: The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).
abstract: Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.
authors.affiliation: Division of Clinical Immunology and Rheumatology, Department of Medicine, Academic Medical Center, Amsterdam, The Netherlands. m.c.kraan@amc.uva.nl
authors.forename: M C
authors.initials: MC
authors.lastname: Kraan
authors.forename: D D
authors.initials: DD
authors.lastname: Patel
authors.forename: J J
authors.initials: JJ
authors.lastname: Haringman
authors.forename: M D
authors.initials: MD
authors.lastname: Smith
authors.forename: H
authors.initials: H
authors.lastname: Weedon
authors.forename: M J
authors.initials: MJ
authors.lastname: Ahern
authors.forename: F C
authors.initials: FC
authors.lastname: Breedveld
authors.forename: P P
authors.initials: PP
authors.lastname: Tak
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016209:Interleukin-8 / Q000096:biosynthesis*; D007719:Knee Joint / Q000737:chemistry / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*
chemical_list: D016209:Interleukin-8