Acute intermittent porphyria, seizures, and antiepileptic drugs: a report on a 3-year-old Nigerian boy.
A 3-year-old Nigerian boy was treated with phenobarbitone after having a nonfebrile seizure. Two weeks later his urine was found to contain porphobilinogen, indicating that latent acute intermittent porphyria had been unmasked by phenobarbitone. The drug was discontinued and carbamazepine was substituted. The urine became free of porphobilinogen and the patient remained well. In developing countries phenobarbitone is the most widely used anticonvulsant; it must be avoided in acute intermittent porphyria, and carbamazepine may be tolerated.
Sykes
R M
RM
Institute of Child Health, University of Benin and University of Benin Teaching Hospital, Benin City, Nigeria.
D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000627:therapeutic use*; D002675:Child, Preschool; D004829:Epilepsy, Generalized / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects*; D011162:Porphobilinogen / Q000652:urine; D017118:Porphyria, Acute Intermittent / Q000175:diagnosis* / Q000652:urine; D012720:Severity of Illness Index
D000927:Anticonvulsants; D002220:Carbamazepine; D011162:Porphobilinogen; D010634:Phenobarbital