[Microabluminuria in arterial hypertension. Measurement, variables, interpretation, recommendations].
Permanent hypertension is frequently associated with increased glomerular permeability to albumin at an early stage, indicating renal involvement and endothelial dysfunction. The definition of microalbuminuria is an urinary albumin excretion of 30-300 mg/24 hrs, confirmed on two occasions over a 3 month period. It may also be expressed in microgram/min, m/l or mg/mmol of creatinine. Radio-immunological, immunonephelometric methods and Elisa are specific and the most sensitive methods of measurement. There is a large intra-individual variability (25-60%) making it essential to repeat measurements always by the same technique. The prevalence of microalbuminuria is 5-8% in the general population and 6-24% in hypertensive patients. When present, it is a marker of increased cardiovascular risk. Clinical recommendations suggest adaptation of urinary collection according to the context: screening, diagnosis or clinical research. It is always necessary to start by dip-stick detection of proteinuria, haematuria or urinary infection. Clinical research requires repeated measurement of 24 hour microalbuminuria, sometimes divided into two periods of day and night, often associated with ambulatory blood pressure recordings and renal function tests. Studies of the effects of anti-hypertensive drugs on microalbuminuria could provide better evaluation. In conclusion, measurement of microalbuminuria remains a tool of clinical research allowing an assessment of cardiovascular and renal risk of hypertensive patients.
Hornych
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Service de néphrologie, hôpital Broussais, 96, rue Didot, 75674 Paris.
Marre
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M
Mimran
A
A
Chaignon
M
M
Asmar
R
R
Fauvel
J P
JP
D000419:Albuminuria / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology; D015995:Prevalence; D012307:Risk Factors