title: Functional MRI activation of individual interictal epileptiform spikes.
abstract: We used spike-triggered functional MRI in a patient with localization-related epilepsy to determine whether individual (as opposed to averaged) focal interictal epileptiform discharges (spikes) were associated with hemodynamic changes detectable with blood oxygen level-dependent functional MRI (fMRI). It was found that 15 of 43 spikes (34.9%) were associated with significant focal fMRI activation. Single event-related fMRI of interictal spikes is feasible in selected patients, giving complementary information to that provided by averaged fMRI data.
authors.affiliation: Epilepsy Research Group, Department of Clinical Neurology, Institute of Neurology, University College London, London and National Society for Epilepsy, Chalfont St. Peter, Buckinghamshire, United Kingdom.
authors.forename: K
authors.initials: K
authors.lastname: Krakow
authors.forename: D
authors.initials: D
authors.lastname: Messina
authors.forename: L
authors.initials: L
authors.lastname: Lemieux
authors.forename: J S
authors.initials: JS
authors.lastname: Duncan
authors.forename: D R
authors.initials: DR
authors.lastname: Fish
mesh_terms: D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D004660:Encephalitis / Q000175:diagnosis / Q000503:physiopathology*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013702:Temporal Lobe / Q000503:physiopathology