Drug-Induced Liver Injury. Cholestatic Injury, Acute and Chronic.
Cholestasis is the failure of bile to reach duodenum due to three different mechanisms: a. alteration of bile secretion by hepatocytes into the canaliculus with or without liver cell damage; b. obstruction of the intrahepatic bile ducts caused by diseases of ductules or small/medium bile ducts; c. obstruction of extrahepatic bile ducts. This short review focuses on drugs which may induce cholestasis by any of these mechanisms.
Degott
Claude
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Hopital Beajuon, Service D'Anatomie et de Cytologie Pathologique, Clichy, France.