Phenolic compounds from Brazilian propolis with pharmacological activities.
Four compounds were isolated from Brazilian propolis. They are identified as: (1) 3-prenyl-4-hydroxycinnamic acid (PHCA), (2) 2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyrane (DCBEN), (3) 3,5-diprenyl-4-hydroxycinnamic acid (DHCA), and (4) 2,2-dimethyl-6-carboxyethenyl-8-prenyl-2H-1-benzopyran (DPB). The structures of the compounds were determined by MS and NMR techniques. All compounds were assayed against Trypanosoma cruzi and the bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus faecalis. Compounds (1) to (4) were active against T. cruzi. Except (1), all compounds presented activity against the bacteria tested. When compounds (1)-(3) were tested in the guinea pig isolated trachea, all induced a relaxant effect similar to propolis extract.
Marcucci
M C
MC
Laboratorio de Fitoquímica, CEBAS (CSIC) Apdo Correos 4195, 30080, Murcia, Spain. mcmarcucci@hotmail.com
Ferreres
F
F
García-Viguera
C
C
Bankova
V S
VS
De Castro
S L
SL
Dantas
A P
AP
Valente
P H
PH
Paulino
N
N
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001938:Brazil; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D011429:Propolis / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014344:Trypanocidal Agents / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D000900:Anti-Bacterial Agents; D010636:Phenols; D014344:Trypanocidal Agents; D011429:Propolis