Role of IL-12 in Staphylococcus aureus-triggered arthritis and sepsis.
The present study demonstrates that endogenous production of IL-12 is crucial for survival in Staphylococcus aureus-induced arthritis in mice. Staphylococcal load is enhanced in several organs, because of lack of IL-12. This might be due to decreased production of IFN-gamma in IL-12-deficient mice. Although IL-12-deficient mice were exposed to higher staphylococcal load, they demonstrated no increased severity of arthritis as compared with control animals.
Hultgren
O H
OH
Department of Rheumatology, University of Göteborg, Göteborg, Sweden. olof.hultgren@immuno.gu.se
Stenson
M
M
Tarkowski
A
A
D000818:Animals; D001170:Arthritis, Infectious / Q000097:blood / Q000276:immunology* / Q000382:microbiology*; D015169:Colony Count, Microbial; D007371:Interferon-gamma / Q000096:biosynthesis / Q000097:blood; D018664:Interleukin-12 / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D007596:Joints / Q000382:microbiology; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018805:Sepsis / Q000276:immunology* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology
D018664:Interleukin-12; D007371:Interferon-gamma