CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon inflammation and demyelination.
Expression of CD1 by microglia, macrophages and T cells was investigated ex vivo. In the healthy central nervous system (CNS), resident microglia, macrophages and T cells express levels of CD1 significantly lower than that expressed by splenic macrophages and T cells. During experimental autoimmune encephalomyelitis (EAE), CD1 expression by microglia and the number of CD1+ microglia increase. Macrophages and T cells strongly upregulate CD1 expression in the CNS, but not in the spleen. Whereas the function of CD1 expressed by T cells remains unclear, the expression by microglia and macrophages provides the CNS with a (glyco)lipidic-presenting molecule in an inflammatory and demyelinating environment.
Busshoff
U
U
Department of Neurobiology, Interdisziplinäres Zentrum für Neurowissenschaften, University of Heidelberg, INF 364, 69120, Heidelberg, Germany.
Hein
A
A
Iglesias
A
A
Dörries
R
R
Régnier-Vigouroux
A
A
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D018949:Antigens, CD1 / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002452:Cell Count; D002490:Central Nervous System / Q000378:metabolism*; D003711:Demyelinating Diseases / Q000378:metabolism*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism* / Q000473:pathology; D039441:Integrin alpha4; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D017628:Microglia / Q000378:metabolism* / Q000473:pathology; D013154:Spleen / Q000378:metabolism / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism* / Q000502:physiology; D015854:Up-Regulation
D015703:Antigens, CD; D018949:Antigens, CD1; D039441:Integrin alpha4