Interleukin 10 expression is correlated with thrombospondin expression and decreased vascular involvement in colon cancer.
Interleukin 10 (IL-10) is an immuno-suppressive cytokine produced by T-lymphocytes, and a regulatory molecule for angiogenesis in various cancers. We examined IL-10 gene expression in 53 colon cancer patients who underwent surgical resection. IL-10 gene expression was correlated with TSP1 and TSP2 gene expression (P=0.0049, P=0.0285). Colon cancer with IL-10 gene expression (19/53) showed significantly decreased venous involvement (P=0.0433). The mean vessel counts in the colon cancers with IL-10 gene expression were significantly lower than those without IL-10 gene expression (P<0.001). These results suggested that IL-10 stimulates angiostatic factor gene expression, and results in suppression of venous involvement.
Kawakami
T
T
Department of Pathology, Tokai University, School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan.
Tokunaga
T
T
Hatanaka
H
H
Tsuchida
T
T
Tomii
Y
Y
Osada
H
H
Onoda
N
N
Morino
F
F
Nagata
J
J
Kijima
H
H
Yamazaki
H
H
Abe
Y
Y
Osamura
Y
Y
Ueyama
Y
Y
Nakamura
M
M
D000230:Adenocarcinoma / Q000098:blood supply / Q000235:genetics / Q000378:metabolism*; D002288:Adenocarcinoma, Mucinous / Q000098:blood supply / Q000235:genetics / Q000378:metabolism*; D026905:Amino Acid Transport Systems; D020533:Angiogenesis Inhibitors; D042683:Angiopoietin-1; D018952:Antigens, CD34 / Q000032:analysis; D002352:Carrier Proteins / Q000378:metabolism; D003110:Colonic Neoplasms / Q000098:blood supply / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers / Q000737:chemistry; D016228:Endothelial Growth Factors / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D011506:Proteins / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D029701:Saccharomyces cerevisiae Proteins; D027981:Symporters; D019700:Thrombospondin 1 / Q000378:metabolism*; D019699:Thrombospondins / Q000378:metabolism; D014158:Transcription, Genetic; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000099262:Thrombospondin 2
D026905:Amino Acid Transport Systems; D020533:Angiogenesis Inhibitors; D042683:Angiopoietin-1; D018952:Antigens, CD34; D002352:Carrier Proteins; D017931:DNA Primers; D016228:Endothelial Growth Factors; D016753:Interleukin-10; D008222:Lymphokines; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011506:Proteins; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; D027981:Symporters; D019700:Thrombospondin 1; D019699:Thrombospondins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000099262:Thrombospondin 2; C402286:Agp2 protein, S cerevisiae