title: The clinical use of deproteinized bovine bone mineral on bone regeneration in conjunction with immediate implant installation.
abstract: Twenty-one c.p. titanium screw-shaped implants were immediately installed after extraction and thorough curettage of the alveoli in 15 patients. Granules of deproteinized bovine bone of 0.25-1.0 mm diameter were used to fill the remaining defect when the distance of the defect wall to the implant surface was > 3 mm. Dimensional measurements of the defect height and width were made with a pocket probe. Fourteen sites in the upper jaw and 7 sites in the lower jaw were thus treated. The mean defect depth varied between 7 mm vestibularly and 10 mm mesially. The mucoperiosteal flaps were hermetically closed. At re-entry, the particles were packed and firmly attached but still distinguishable from the surrounding bone. Of the 21 sites treated, 5 sites had an exposure of the implant cover screw during the healing period. An exposure of the granular material occurred in 4 sites, but loss of granules in only 3. Even in these sites no signs of infection or inflammation of the soft tissues were observed. At re-entry after 6 months, 10 sites were completely and 9 partially filled. For the partial fills, the mean remaining defect height was 1.6 mm (range: 0.6-3.0 mm). Two sites showed an increased defect of respectively 2.4 and 4.8 mm. No fixtures were lost. The present results indicate that deproteinized bovine bone is a safe filling material to fill remaining defects around implants installed in fresh extraction sockets.
authors.affiliation: Department of Periodontology, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Catholic University, Leuven, Belgium. Daniel.vansteenberghe@uz.kuleuven.ac.be
authors.forename: D
authors.initials: D
authors.lastname: van Steenberghe
authors.forename: A
authors.initials: A
authors.lastname: Callens
authors.forename: L
authors.initials: L
authors.lastname: Geers
authors.forename: R
authors.initials: R
authors.lastname: Jacobs
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003758:Dental Implantation, Endosseous / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000494:pharmacology; D018709:Statistics, Nonparametric; D014081:Tooth Extraction; D020390:Tooth Socket; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals