title: Study of temporal and perfusion physiology of skin capillaries in the dorsum of the foot.
abstract: The aim of this study was twofold: firstly, to study the nature of any temporal variation in capillary numbers, and secondly to determine the proportion of perfused to total nutritional capillaries in normal skin. Using in vivo microscopy, the temporal behaviour of the number of visible capillaries in the skin of the dorsum of foot was observed over periods of time varying from 5 min to 55 days in 15 healthy subjects. Capillary perfusion was then studied by comparing capillary numbers before and after intravenous injection of sodium fluorescein. The mean percent difference in the number of visible capillaries over a mean period of 25.3 days was 5.5%. The percentage ratio of perfused to total capillaries was 54.2%. This study shows that there is little quantitative change in capillary numbers over periods of up to 50 days, and that under physiological conditions, about half of the nutritional capillaries of skin are not perfused.
authors.affiliation: Department of Surgery, St. George's Hospital Medical School, London, UK. marclamah@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Lamah
authors.forename: P S
authors.initials: PS
authors.lastname: Mortimer
authors.forename: J A
authors.initials: JA
authors.lastname: Dormandy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002196:Capillaries / Q000502:physiology; D005260:Female; D019793:Fluorescein; D005456:Fluorescent Dyes; D005528:Foot / Q000098:blood supply*; D006801:Humans; D008297:Male; D008833:Microcirculation; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D012016:Reference Values; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D013997:Time Factors
chemical_list: D005456:Fluorescent Dyes; D019793:Fluorescein