Functional and structural measurements in a multifactorial glaucoma risk model.
OBJECTIVE
To evaluate the relationship between a multifactorial probability risk model of developing glaucomatous visual field defects and the assessment of the retinal nerve fiber layer (RNFL) and short-wavelength automated perimetry (SWAP) in glaucoma suspects.


METHODS
157 eyes of 157 glaucoma suspects were included in the study. The risk of developing glaucomatous defects was assessed by applying a multifactorial model that included intraocular pressure, vertical cup-to-disk ratio, age and family history. Photographs of the RNFL and SWAP were performed.


RESULTS
The SWAP was abnormal in 54 cases (34.3%); 21% of abnormal perimetries were obtained in the low-risk group, 37% in the moderate risk group and 56% in the high risk group. The nerve fiber layer evaluation in the different risk stages showed a pattern similar to the results obtained with SWAP. Multiple regression analyses, performed with the four variables included in the model with SWAP and RNFL evaluation, showed the relationship between the risk factors and the presence of glaucomatous damage--evaluated by RNFL and SWAP (p<0001).


CONCLUSIONS
The probability model showed a good correlation between the risk scale and the RNFL and SWAP assessment.
Polo
V
V
Department of Ophthalmology, Miguel Servet Hospital, Zaragoza, Spain.
Abecia
E
E
Pablo
L E
LE
Pinilla
I
I
Larrosa
J M
JM
Honrubia
F M
FM
D000328:Adult; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D015233:Models, Statistical; D009412:Nerve Fibers / Q000473:pathology; D009798:Ocular Hypertension / Q000175:diagnosis; D011336:Probability; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology; D012307:Risk Factors; D014786:Vision Disorders / Q000175:diagnosis*; D014792:Visual Acuity; D058609:Visual Field Tests; D014794:Visual Fields