Novel treatment of meningitis caused by multidrug-resistant Mycobacterium tuberculosis with intrathecal levofloxacin and amikacin: case report.
We report the case of a 25-year-old HIV-negative man with disseminated multidrug-resistant tuberculosis (MDRTB), who-on a retreatment regimen-experienced total resolution of TB miliary disease, but progressive TB meningitis. Therefore, intrathecal treatment with amikacin and levofloxacin was instituted, with successful clinical and microbiological results.
Berning
S E
SE
Department of Medicine, National Jewish Medical and Research Center, University of Colorado School of Pharmacy, Denver, CO 80206, USA. bernings@njc.org
Cherry
T A
TA
Iseman
M D
MD
D000328:Adult; D000583:Amikacin / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007278:Injections, Spinal; D064704:Levofloxacin; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D014390:Tuberculosis, Meningeal / Q000188:drug therapy* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D064704:Levofloxacin; D000583:Amikacin; D015242:Ofloxacin