title: Crawling and wiggling on DNA: structural insights to the mechanism of DNA unwinding by helicases.
abstract: Crystal structures have recently been solved of the monomeric DNA helicase PcrA bound to forked DNA, and of the hexameric helicase domain of the bacteriophage T7 gene 4 protein, a replication fork DNA helicase/primase. These structures have led to the elaboration of the first molecular models to describe DNA helicase action.
authors.affiliation: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. k-marians@ski.mskcc.org
authors.forename: K J
authors.initials: KJ
authors.lastname: Marians
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D003198:Computer Simulation; D004265:DNA Helicases / Q000737:chemistry* / Q000378:metabolism*; D019915:DNA Primase / Q000737:chemistry / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; C084217:pcrA protein, Bacteria; D019915:DNA Primase; D004265:DNA Helicases