ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men.
A number of previous investigations showed significant associations between polymorphisms of the vitamin D receptor (VDR) gene and bone mineral density (BMD). BMD is influenced by hormones and the rate of skeletal remodeling. A study was performed to investigate the possible relationship between Apa I, Bsm I, Taq I, and Fok I polymorphisms of the VDR gene and serum 1,25-dihydroxyvitamin D (1,25[OH]2D), osteocalcin, and propeptide of type I collagen (PICP)-markers of bone turnover, total body calcium, and BMD of the total body, radius, lumbar spine, trochanter, and femoral neck-in 39 young adult black men of 20 to 40 years of age and 44 age-, height-, and weight-matched white men. The distribution of each of the four alleles of the VDR genotypes was similar in the two racial groups. The Apa I VDR genotype was associated with serum PICP (P =.0494) but not with serum 1,25(OH)2D or serum osteocalcin. A significant association between the Apa I VDR genotype and BMD of the lumbar spine (P =.0291) was also observed. However, the Bsm I, Taq I, and Fok I genotypes were not significantly associated with BMD or serum osteocalcin, PICP, or 1,25(OH)2D. Multivariate stepwise analysis indicated that (1) the Apa I VDR genotype was associated with BMD of the lumbar spine in the two groups together; with total body calcium and BMD of the total body, radius, trochanter, and femoral neck in the black men; and with BMD of the radius in the white men; analysis also indicated that (2) race was significantly associated with total body calcium and BMD of the total body, lumbar spine, and femoral neck. In summary, the Apa I VDR genotype is associated with serum PICP and BMD at a number of sites but does not contribute to or account for racial differences in BMD in young adult men.
Bell
N H
NH
Departments of Medicine, Pharmacology, and Pediatrics, Medical University of South Carolina, Charleston, USA.
Morrison
N A
NA
Nguyen
T V
TV
Eisman
J
J
Hollis
B W
BW
D000328:Adult; D000483:Alleles; D015415:Biomarkers / Q000032:analysis; D044383:Black People; D015519:Bone Density; D016723:Bone Remodeling; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000032:analysis; D015252:Deoxyribonucleases, Type II Site-Specific; D005838:Genotype; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D012150:Polymorphism, Restriction Fragment Length; D011347:Procollagen / Q000097:blood; D044469:Racial Groups; D018167:Receptors, Calcitriol / Q000235:genetics*; D044465:White People
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; D018167:Receptors, Calcitriol; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; C053864:endodeoxyribonuclease BsmI; C035042:endodeoxyribonuclease FokI; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases; C027046:TCGA-specific type II deoxyribonucleases; D002117:Calcitriol; D002118:Calcium