Virology. Probing HIV's elusive activities within the host cell.
Once inside a host cell, HIV must make its way to the nucleus in order to replicate, but until now, its journey has largely been uncharted territory. As researchers begin to explore this landscape a common theme is emerging: Soon after viruses enter cells, they enlist components of their hosts to assist them in their journey. Now, in what is being called one of the most exciting frontiers in AIDS research, preliminary findings on how HIV enters cell nuclei are giving AIDS researchers new leads on possible drug targets to fight the ever-mounting epidemic.
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D002462:Cell Membrane / Q000821:virology; D002467:Cell Nucleus / Q000821:virology*; D003593:Cytoplasm / Q000821:virology; D004247:DNA / Q000378:metabolism; D004279:DNA, Viral / Q000378:metabolism; D015870:Gene Expression; D016336:Gene Products, vpr / Q000378:metabolism; D016679:Genome, Viral; D006678:HIV / Q000235:genetics / Q000502:physiology*; D015658:HIV Infections / Q000821:virology*; D019427:HIV Integrase / Q000378:metabolism; D006801:Humans; D008264:Macrophages / Q000821:virology; D008870:Microtubules / Q000502:physiology / Q000821:virology; D009685:Nuclear Envelope / Q000821:virology; D019913:Nuclear Localization Signals; D013601:T-Lymphocytes / Q000821:virology; D014158:Transcription, Genetic; D014763:Viral Matrix Proteins / Q000378:metabolism; D016662:Virus Integration; D054325:vpr Gene Products, Human Immunodeficiency Virus
D004279:DNA, Viral; D016336:Gene Products, vpr; D019913:Nuclear Localization Signals; D014763:Viral Matrix Proteins; C051802:triplex DNA; D054325:vpr Gene Products, Human Immunodeficiency Virus; D004247:DNA; D019427:HIV Integrase