title: Effect of vagal autotransplantation on quantitative [3H]-vesamicol binding image in rats with unilateral lesions of nucleus baslis magnocellularis.
abstract: It is considered that nodosal ganglion grafting improves learning and memory disorder in nucleus basalis magnocellularis lesioned rats, and that [3H]-vesamicol is one of the mapping agents for presynaptic cholinergic neurons. Quantitative autoradiography was performed using high sensitive imaging plate system to evaluate the effect of neurotransplantation on [3H]-vesamicol binding. The affected-side to unaffected-side ratio of [3H]-vesamicol in the nucleus basalis magnocellularis lesioned group was significantly lower than that in the sham-operated group at 1, 2 and 4weeks (P<0.01). In the transplanted group, the ratio was significantly higher than that in the untreated group at 4weeks (P<0.05). [3H]-vesamicol binding is one of the most sensitive indicators of nucleus basalis magnocellularis lesions and the effect of the nodosal ganglion grafting.
authors.affiliation: Department of Nuclear Medicine, Kanazawa University School of Medicine, 13-1 Takara-machi, 920-8640, Kanazawa, Japan. eikeda1@mac.com
authors.forename: E
authors.initials: E
authors.lastname: Ikeda
authors.forename: A
authors.initials: A
authors.lastname: Ichikawa
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Shiba
authors.forename: I
authors.initials: I
authors.lastname: Kuji
authors.forename: H
authors.initials: H
authors.lastname: Sumiya
authors.forename: N
authors.initials: N
authors.lastname: Tonami
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D001345:Autoradiography; D020532:Basal Nucleus of Meynert / Q000033:anatomy & histology / Q000378:metabolism*; D007091:Image Processing, Computer-Assisted; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000378:metabolism*; D010880:Piperidines / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014182:Transplantation, Autologous / Q000502:physiology*; D014630:Vagus Nerve / Q000637:transplantation*
chemical_list: D009467:Neuromuscular Depolarizing Agents; D010880:Piperidines; C006189:vesamicol