title: Identification of reaction products of methamphetamine and hydrogen peroxide in hair dye and decolorant treatments by high-performance liquid chromatography/mass spectrometry.
abstract: The effect of hydrogen peroxide, a main component of hair dye and decolorant treatments, on methamphetamine (MA) was studied. Two analytical methods, thin-layer chromatography (TLC) and high-performance liquid chromatography/mass spectrometry (LC/MS), were used for the separation and identification of MA derivatives. Mixtures of MA solutions and hydrogen peroxide that had been incubated at 39 degrees C for 24 h were shown to contain para-hydroxy MA by TLC and para-, meta- and ortho-hydroxy MAs by LC/MS. In addition, MA N-oxide and N-hydroxy MA were found in MA/hydrogen peroxide mixtures immediately after mixing. Therefore, we concluded that MA changed to MA N-oxide and N-hydroxy MA before changing to para-, meta- and ortho-hydroxy MAs.
authors.affiliation: Forensic Science Laboratory, Ishikawa Prefectural Police Headquarters, 2-1-1 Hirosaka, Kanazawa 920-8553, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: R
authors.initials: R
authors.lastname: Iio
authors.forename: S
authors.initials: S
authors.lastname: Chinaka
authors.forename: N
authors.initials: N
authors.lastname: Takayama
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006202:Hair Dyes / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods*; D008694:Methamphetamine / Q000737:chemistry*
chemical_list: D006202:Hair Dyes; D008694:Methamphetamine; D006861:Hydrogen Peroxide