[Progress in the knowledge on endothelial dysfunction and its application in clinical practice].
The endothelium plays a crucial role in the maintenance of vascular homeostasis; endothelial cells produce a series of molecules that determine vascular tone and modulate the interactions between the arterial wall components and the circulating blood. Endothelial dysfunction (ED) thus results in significantly impaired physiological responses that often lead to atheroma formation. Recent studies suggest that endothelial dysfunction as assessed invasively during coronary angiography is a prognostic marker. Recently, a non-invasive ultrasound technique has been developed which may allow screening of ED in both patients and healthy subjects. This article reviews current knowledge regarding non-invasive assessment of endothelial dysfunction and proposes potential uses of a promising ultrasound technique.
Simón
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Coronary Artery Disease Research Unit, Department of Cardiological Sciences, St. George's Hospital Medical School, London SW17 0RE, UK.
Castro
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Kaski
J C
JC
D002320:Cardiovascular Physiological Phenomena; D015510:Clinical Medicine; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology*; D006801:Humans; D014652:Vascular Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology