title: Dynamic relationship of cycle length to reentrant circuit geometry and to the slow conduction zone during ventricular tachycardia.
abstract: BACKGROUND
  Knowledge of cycle-to-cycle changes in isthmus geometry is of potential importance for radiofrequency catheter ablation to stop reentrant ventricular tachycardia. It was hypothesized that isthmus geometry often undergoes continuous evolution throughout reentry and that cycle-length variability measurements could be used to segment reentry into distinct phases and to predict changes in isthmus geometry.
  
  
  RESULTS
  A canine infarct model of reentrant ventricular tachycardia in the epicardial border zone with a figure 8 pattern of conduction was used for analysis (25 monomorphic reentry episodes, 20 experiments). Tachycardias were segmented, on the basis of cycle-length variations, into 2 to 3 distinct phases corresponding to onset, maintenance, and spontaneous termination, when it occurred (6/25 episodes). Trends of linear cycle-length change occurred throughout the maintenance phase in all tachycardias. For each trend, quantitative geometric parameters of the isthmus were measured, and the following linear relationships were established. During a trend, the slow conduction zone activation interval and tachycardia cycle length increased, while isthmus length decreased. When isthmus length decreased, isthmus width decreased at its narrowed portion. Larger decreases in isthmus length corresponded to higher rates of linear cycle-length prolongation. Also, greater cycle-length variability tended to prolong tachycardia.
  
  
  CONCLUSIONS
  Cycle-length alterations occur throughout reentry in this canine model and are predictive of isthmus geometry changes. Because similar reentry dynamics, which affect catheter ablation efficacy, have been observed clinically, estimation of changes in geometry during electrophysiological study may help target ablation sites.
authors.affiliation: Departments of Pharmacology and Biomedical Engineering, College of Physicians and Surgeons, Columbia University, New York, NY, USA. ciaccio@columbia.edu
authors.forename: E J
authors.initials: EJ
authors.lastname: Ciaccio
mesh_terms: D000818:Animals; D001683:Biological Clocks; D018780:Body Surface Potential Mapping; D004195:Disease Models, Animal; D004285:Dogs; D022062:Electrophysiologic Techniques, Cardiac; D006329:Heart Conduction System / Q000473:pathology / Q000503:physiopathology*; D006339:Heart Rate; D011930:Reaction Time; D017180:Tachycardia, Ventricular / Q000473:pathology / Q000503:physiopathology*