Use of transgenic animals to investigate drug hypersensitivity.
Hypersensitivity reactions to drugs and environmental agents are often due to exaggerated humoral (Th(2)) or cell mediated (Th(1)) immune responses with typical cytokine profiles. Overexpression of Th(2) cytokines, such as IL-4, IL-5 or IL-13 in mice, enhances an IgE antibody mediated response, while deletion of these cytokines attenuates and/or prevents allergic responses. Conversely, modulation of Th(1) cytokine gene expression may affect cell-mediated immune responses. Therefore, cytokine transgenic mice are used as investigative tools to study potential chemicals and/or drug allergies. In addition to cytokines and chemokines, other factors are important for the development of allergic responses, such as IgE, Fc receptors, vasopressin and several other factors, which can be tested in transgenic mice.
Moser
R
R
Institute of Biopharmaceutical Research, Matzingen, Pharma Novartis AG, Basel, Switzerland.
Quesniaux
V
V
Ryffel
B
B
D000485:Allergens / Q000633:toxicity*; D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000503:physiopathology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D023421:Models, Animal; D018418:Th2 Cells / Q000187:drug effects / Q000378:metabolism; D015262:Xenobiotics / Q000633:toxicity*
D000485:Allergens; D016207:Cytokines; D015262:Xenobiotics