Transgenic mice overexpressing gamma-aminobutyric acid transporter subtype I develop obesity.
Transgenic mice ubiquitously overexpressing murine gamma-aminobutyric acid transporter subtype I were created. Unexpectedly, these mice markedly exhibited heritable obesity, which features significantly increased body weight and fat deposition. Behavioral examination revealed that transgenic mice have slightly reduced spontaneous locomotive capacity and altered feeding pattern. This preliminary finding indicates that the inappropriate level of gamma-aminobutyric acid transporters may be directly or indirectly involved in the pathogenic mechanism underlying certain types of obesity.
Ma
Y H
YH
Institute of Biochemistry and Cell Biology, Chinese Academy of Science, Shanghai.
Hu
J H
JH
Zhou
X G
XG
Zeng
R W
RW
Mei
Z T
ZT
Fei
J
J
Guo
L H
LH
D000818:Animals; D001835:Body Weight; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004435:Eating; D050485:GABA Plasma Membrane Transport Proteins; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009765:Obesity / Q000235:genetics* / Q000378:metabolism*; D027361:Organic Anion Transporters; D014280:Triglycerides / Q000097:blood
D002352:Carrier Proteins; D050485:GABA Plasma Membrane Transport Proteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D027361:Organic Anion Transporters; D014280:Triglycerides; D002784:Cholesterol