Biochemistry. An absorbing study of cholesterol.
We obtain sterols from the animal and plant food that we eat. How these plant and animal sterols are absorbed, transported around the body, and excreted has been the subject of much investigation. In a Perspective, Allayee and colleagues discuss a new study (Berge et al.) that implicates two new ABC transporter proteins in the efflux of plant and animal sterols from gut epithelial cells into the gut lumen.
Allayee
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Department of Medicine, University of California, Los Angeles (UCLA) School of Medicine, Los Angeles, CA 90095, USA. hallayee@ucla.edu
Laffitte
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BA
Lusis
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AJ
D000071019:ATP Binding Cassette Transporter, Subfamily G, Member 8; D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D002784:Cholesterol / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D002889:Chromosomes, Human, Pair 2; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D008052:Lipid Metabolism, Inborn Errors / Q000235:genetics* / Q000378:metabolism; D008074:Lipoproteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D000071518:Liver X Receptors; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D012855:Sitosterols / Q000097:blood* / Q000378:metabolism
C416946:ABCG8 protein, human; D000071019:ATP Binding Cassette Transporter, Subfamily G, Member 8; D018528:ATP-Binding Cassette Transporters; D002791:Cholesterol, Dietary; D004268:DNA-Binding Proteins; D008074:Lipoproteins; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D012855:Sitosterols; D000255:Adenosine Triphosphate; D002784:Cholesterol