title: Drug-Induced Liver Injury. Cholestatic Injury, Acute and Chronic.
abstract: Cholestasis is the failure of bile to reach duodenum due to three different mechanisms: a. alteration of bile secretion by hepatocytes into the canaliculus with or without liver cell damage; b. obstruction of the intrahepatic bile ducts caused by diseases of ductules or small/medium bile ducts; c. obstruction of extrahepatic bile ducts. This short review focuses on drugs which may induce cholestasis by any of these mechanisms.
authors.affiliation: Hopital Beajuon, Service D'Anatomie et de Cytologie Pathologique, Clichy, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Degott