title: Polyether antibiotic CP44,161.
abstract: The crystal structure of antibiotic CP44,161, 6-(7-(2-ethyl-2-[5-(1-hydroxymethyl)-5-methyl-2,3,4,5-tetrahydro-2-furyl]-4,10,-12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl)-4-hydroxy-3,5-dimethyl-6-oxononyl)-2-hydroxy-3-methylbenzoic acid monohydrate, C43H66O10.H2O, has been determined by X-ray crystallography. The molecule adopts a cyclic conformation, with a centrally located water molecule contributing to the stability of the conformation through hydrogen-bonding interactions.
authors.affiliation: School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia.
authors.forename: P
authors.initials: P
authors.lastname: Allen
authors.forename: M A
authors.initials: MA
authors.lastname: Brimble
authors.forename: P
authors.initials: P
authors.lastname: Turner
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D004987:Ethers / Q000737:chemistry* / Q000302:isolation & purification; D006860:Hydrogen Bonding; D008848:Micromonosporaceae / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011714:Pyrans / Q000737:chemistry; D013302:Streptomyces; D000095662:Polyether Polyketides
chemical_list: D000900:Anti-Bacterial Agents; D001952:Bridged-Ring Compounds; D004987:Ethers; D011714:Pyrans; C425408:CP44,161; C010327:salinomycin; D000095662:Polyether Polyketides