title: Chromosomal passengers and the (aurora) ABCs of mitosis.
abstract: Chromosomal passengers are proteins that move from centromeres to the spindle midzone during mitosis. Recent experiments show that the passengers inner centromere protein (INCENP) and aurora-B kinase are in a macromolecular complex that might also contain a third passenger, survivin. The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesis.
authors.affiliation: Wellcome Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Michael Swann Building, King's Buildings, Mayfield Road, EH9 3JR, Edinburgh, UK.
authors.forename: R R
authors.initials: RR
authors.lastname: Adams
authors.forename: M
authors.initials: M
authors.lastname: Carmena
authors.forename: W C
authors.initials: WC
authors.lastname: Earnshaw
mesh_terms: D064107:Aurora Kinase B; D064127:Aurora Kinases; D016923:Cell Death / Q000502:physiology; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D009363:Neoplasm Proteins; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D002868:Chromosomal Proteins, Non-Histone; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011506:Proteins; D000077022:Survivin; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases