title: In vitro uptake of SCH 27899 (evernimicin) by rat alveolar macrophages.
abstract: The in vitro uptake of [(14)C]evernimicin ([(14)C]SCH 27899) by primary cultures of rat alveolar macrophages and hepatocytes was determined. Both cell populations exhibited linear rates of uptake. However, the initial rate of drug uptake by alveolar macrophages was about threefold higher than that by hepatocytes. These findings demonstrate that [(14)C]evernimicin is taken up by rat alveolar macrophages, supporting the likelihood that the drug is able to reach sites of infection.
authors.affiliation: Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Kenilworth, New Jersey 07033-1300, USA. shmuel.zbaida@spcorp.com
authors.forename: S
authors.initials: S
authors.lastname: Zbaida
authors.forename: J
authors.initials: J
authors.lastname: Brieland
authors.forename: P
authors.initials: P
authors.lastname: Krieter
authors.forename: D
authors.initials: D
authors.lastname: Loebenberg
authors.forename: G
authors.initials: G
authors.lastname: Krishna
authors.forename: D
authors.initials: D
authors.lastname: Horne
authors.forename: X
authors.initials: X
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Yuan
authors.forename: R
authors.initials: R
authors.lastname: Hare
authors.forename: M N
authors.initials: MN
authors.lastname: Cayen
authors.forename: J E
authors.initials: JE
authors.lastname: Patrick
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D001692:Biological Transport; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D022781:Hepatocytes / Q000378:metabolism; D016676:Macrophages, Alveolar / Q000378:metabolism*; D019275:Radiopharmaceuticals / Q000378:metabolism; D051381:Rats
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; C001202:evernimicin