title: Medical treatment for reflux oesophagitis does not consistently improve asthma control: a systematic review.
abstract: BACKGROUND
  A systematic literature review was conducted to assess the effect of treating reflux oesophagitis on asthma outcomes.
  
  
  METHODS
  Randomised controlled trials of reflux oesophagitis treatment in adults or children that reported asthma health outcomes were included and assessed in accordance with the standard Cochrane systematic review process. Patients were typically adults with asthma and concurrent symptomatic gastro-oesophageal reflux who received interventions that included pharmacological therapy, conservative management, and surgery. The following outcome measures were assessed: lung function, peak expiratory flow, asthma symptoms, asthma medications, and nocturnal asthma.
  
  
  RESULTS
  From 22 potentially relevant published and unpublished randomised controlled trials, 12 were included. Treatment duration ranged from 1 week to 6 months. Eight trials reported that treatment improved at least one asthma outcome, but these outcomes differed between trials. Overall, treatment of reflux oesophagitis did not consistently improve forced expiratory volume in one second (FEV(1)), peak expiratory flow rate, asthma symptoms, nocturnal asthma symptoms, or use of asthma medications in asthmatic subjects. Significant improvement in wheeze was reported in two studies.
  
  
  CONCLUSIONS
  The published literature does not consistently support treatment of reflux oesophagitis as a means of controlling asthma. Further large randomised controlled trials in subjects with a demonstrated temporal relationship between gastro-oesophageal reflux and asthma are needed. These trials should be conducted over at least 6 months to allow adequate time to observe a treatment effect.
authors.affiliation: Department of Medicine, John Hunter Hospital, Locked Bag 1, Hunter Region Mail Centre, NSW 2310, Australia.
authors.forename: J L
authors.initials: JL
authors.lastname: Coughlan
authors.forename: P G
authors.initials: PG
authors.lastname: Gibson
authors.forename: R L
authors.initials: RL
authors.lastname: Henry
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control*; D002648:Child; D004942:Esophagitis, Peptic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome