Idiotypic regulation of anti-factor VIII antibodies.
This review focuses on the relationship between natural autoreactivity, autoimmunity in disease and antigen-driven immune responses to factor VIII and on idiotype-mediated immune regulation of anti-factor VIII antibodies in health and disease.
Kazatchkine
M D
MD
INSERM U430 and University Pierre et Marie Curie, H pital Broussais, Paris, France.
Lacroix-Desmazes
S
S
Moreau
A
A
Kaveri
S V
SV
D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D005169:Factor VIII / Q000276:immunology*; D006467:Hemophilia A / Q000276:immunology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000097:blood; D007518:Isoantibodies / Q000097:blood / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes; D007518:Isoantibodies; D005169:Factor VIII