Biosynthesis of natural products on modular peptide synthetases.
Microbial nonribosomally processed peptides represent a large class of natural products including numerous important pharmaceutical agents, as well as other representatives that play a prevalent role in pathogenicity of certain microorganisms [M. A. Marahiel, T. Stachelhaus, and H. D. Mootz (1997). Chem. Rev. 97, 2651-2673]. Although diverse in structure, nonribosomally synthesized peptides have a common mode of biosynthesis. They are assembled on very large protein templates called peptide synthetases that exhibit a modular organization, allowing polymerization of monomers in an assembly-line-like mechanism.
Doekel
S
S
Fachbereich Chemie/Biochemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, Marburg, 35032, Germany. doekel@chemie.uni-marburg.de
Marahiel
M A
MA
D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D001688:Biological Products / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D005658:Fungi / Q000201:enzymology / Q000235:genetics; D005798:Genes, Bacterial; D005800:Genes, Fungal; D018716:Molecular Mimicry; D016297:Mutagenesis, Site-Directed; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism*
D001688:Biological Products; D010453:Peptide Synthases