title: Whole-bladder irradiation and doxorubicin-containing chemotherapy as successful treatment for a primary mucosa-associated lymphoid tissue lymphoma of the bladder.
abstract: Primary bladder lymphoma, a rare disease, is usually of the low-grade mucosa-associated lymphoid tissue (MALT) type. The best treatment approach for this disease remains unknown. We encountered a case of localized MALT lymphoma with a partial high-grade component in a 27-year-old Japanese man. Taking therapeutic efficacy and the quality of life of the patient into consideration, we treated him with a combination of doxorubicin-containing chemotherapy and 30-Gy whole-bladder irradiation. The patient had a complete remission and has been disease-free without serious adverse effects or sequelae for a year and a half since completion of the treatment. These observations suggest that a combination of systemic chemotherapy and relatively low-dose irradiation without a total cystectomy is effective for a MALT lymphoma of the bladder, even with a high-grade component.
authors.affiliation: Division of Hematology, Suzuka General Hospital, Mie, Japan. kawakei@cocoa.ocn.ne.jp
authors.forename: K
authors.initials: K
authors.lastname: Kawakami
authors.forename: K
authors.initials: K
authors.lastname: Oka
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Shiku
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D001743:Urinary Bladder / Q000528:radiation effects; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D004317:Doxorubicin