title: Evolution of Streptococcus pneumoniae serotypes and antibiotic resistance in Belgium-update (1994-98).
abstract: OBJECTIVE
  To follow the evolution of capsular types and resistance of Streptococcus pneumoniae, isolated from deep sites.
  
  
  METHODS
  More than 100 Belgian laboratories permanently collect S. pneumoniae strains isolated from puncture specimens (blood, cerebrospinal fluid, middle ear fluid, etc.) and forward them to the reference center in Leuven, in order to determine the capsular serogroups and types (SGTs) and their resistance.
  
  
  RESULTS
  From 1994 to 1998, the 5486 S. pneumoniae strains examined belonged to 39 of the 46 currently identified SGTs. The 10 most frequent SGTs accounted for 78.9% of the isolates, and 97% of all isolates belonged to SGTs included in the 23-valent vaccine. Overall mortality of patients with pneumococcal bacteremia or meningitis was 9.7%, and 23.8% in patients over 80 years. From 1994 to 1998, resistance to penicillin (P) increased from 7.6% to 14.2%, to tetracycline (T) from 14.9% to 28.0%, and to erythromycin (E) from 22.9% to 31%. Triple resistance (PTE) increased from 0.9% in 1994 to 6.6% in 1998. Five SGTs (6, 9, 14, 19 and 23) accounted for 50% of the isolates, but for > 90% of the penicillin-resistant or erythromycin-resistant isolates.
  
  
  CONCLUSIONS
  Resistance of S. pneumoniae to penicillin, erythromycin and tetracycline is steadily increasing and is concentrated in five serotypes included in the 23-valent pneumococcal vaccine. Increasing resistance and high mortality of invasive infections are an incentive to vaccinate vulnerable groups.
authors.affiliation: Department of Microbiology, University Hospital Leuven, Belgium. Jan.Verhaegen@uz.kuleuven.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Verhaegen
authors.forename: J
authors.initials: J
authors.lastname: Van De Ven
authors.forename: N
authors.initials: N
authors.lastname: Verbiest
authors.forename: J
authors.initials: J
authors.lastname: Van Eldere
authors.forename: L
authors.initials: L
authors.lastname: Verbist
mesh_terms: D000293:Adolescent; D000328:Adult; D001530:Belgium; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000401:mortality; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000187:drug effects / Q000302:isolation & purification