Neurological disease-associated autoantibodies against an unknown protein encoded by a RES4-22 homologous gene.
Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti-res4-22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti-res4-22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.
Amin
M
M
Department of Clinical Chemistry and Pathobiochemistry, University Hospital, Leipzig, Germany.
Uhlig
H H
HH
Kamprad
M
M
Karbe
J
J
Osman
A A
AA
Grahmann
F
F
Hummelsheim
H
H
Mothes
T
T
D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000235:genetics / Q000276:immunology*; D020274:Autoimmune Diseases of the Nervous System / Q000097:blood / Q000235:genetics / Q000276:immunology; D002545:Brain Ischemia / Q000097:blood / Q000276:immunology; D002531:Cerebellum / Q000276:immunology; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D015723:Gene Library; D005796:Genes; D006801:Humans; D000071058:Huntingtin Protein; D007070:Immunoglobulin A / Q000276:immunology*; D007413:Intestinal Mucosa / Q000737:chemistry; D007421:Intestine, Small / Q000737:chemistry; D008856:Microscopy, Fluorescence; D009130:Muscle, Smooth / Q000737:chemistry; D009186:Myelin Sheath / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000276:immunology*; D009422:Nervous System Diseases / Q000097:blood / Q000235:genetics / Q000276:immunology*; D009687:Nuclear Proteins / Q000235:genetics; D011506:Proteins; D012583:Schwann Cells / Q000737:chemistry; D012689:Sequence Homology, Nucleic Acid
D001323:Autoantibodies; D001324:Autoantigens; C422982:FAM193A protein, human; C086055:HTT protein, human; D000071058:Huntingtin Protein; D007070:Immunoglobulin A; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D011506:Proteins