title: B-mode, power Doppler and contrast-enhanced power Doppler ultrasonography in the diagnosis of breast tumors.
abstract: OBJECTIVE
  To investigate the role of B-mode and unenhanced and enhanced power Doppler ultrasonography (US) in differentiating solid breast lesions, and to find out whether morphologically different tumors differ in terms of vascularity.
  
  
  METHODS
  Sixty-five lesions, indeterminate or suggestive of malignancy after mammography were prospectively examined with B-mode and unenhanced and enhanced power Doppler US. The lesions were classified as benign, indeterminate or malignant at B-mode, and as benign or malignant at power Doppler US. The results were compared to the histologic diagnoses. Vascularity was analyzed also quantitatively to find out whether threshold values for differential diagnostics could be set.
  
  
  RESULTS
  The sensitivity, specificity, and overall accuracy of the morphologic evaluation were 100%, 10%, and 57%, respectively. Rounded lesions were more vascular than spiculated lesions, but vascular assessment was only helpful when it supported a benign morphology. In quantitative analysis, due to the overlap between the benign and malignant lesions, no threshold values could be set.
  
  
  CONCLUSIONS
  Morphologic criteria were useful in characterizing malignant lesions, but the large proportion of indeterminate findings decreased the specificity of US. Neither unenhanced, nor enhanced power Doppler US was able to improve diagnostic accuracy.
authors.affiliation: Department of Diagnostic Radiology, Oulu University Central Hospital, Finland.
authors.forename: H
authors.initials: H
authors.lastname: Reinikainen
authors.forename: T
authors.initials: T
authors.lastname: Rissanen
authors.forename: M
authors.initials: M
authors.lastname: Päivänsalo
authors.forename: E
authors.initials: E
authors.lastname: Pääkkö
authors.forename: J
authors.initials: J
authors.lastname: Jauhiainen
authors.forename: I
authors.initials: I
authors.lastname: Suramo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D001943:Breast Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018567:Breast Neoplasms, Male / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler / Q000379:methods*