Homocysteine and transmethylations in uremia.
Homocysteine is regarded as a cardiovascular risk factor in both the general population and chronic renal failure patients. Among the mechanisms for homocysteine toxicity, its interference with transmethylation reactions, through its precursor/derivative S-adenosylhomocysteine, plays a multifarious role. In uremia, inhibition of S-adenosylmethionine methyl transfer reactions has been reported by independent investigators, using multiple approaches. This has several possible consequences, which can ultimately affect the patient's relative state of health.
Perna
A F
AF
Division of Nephrology and Institute of Biochemistry of Macromolecules, SUN School of Medicine, Naples, Italy.
Ingrosso
D
D
Castaldo
P
P
Galletti
P
P
De Santo
N G
NG
D000215:Acylation; D000596:Amino Acids / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000209:etiology; D006710:Homocysteine / Q000378:metabolism*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000453:epidemiology; D008745:Methylation; D009603:Nitroso Compounds / Q000378:metabolism; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism; D014511:Uremia / Q000150:complications / Q000378:metabolism*
D000596:Amino Acids; D009603:Nitroso Compounds; D011506:Proteins; D006710:Homocysteine