title: Synthesis of diastereomerically enriched 2-bromoesters and their reaction with nucleophiles.
abstract: 2-Bromoesters enriched in the (S,R)-diastereoisomer can be easily prepared by coupling of racemic 2-bromoacids with (R)-pantolactone. Displacement of the bromine atom with nucleophiles, under suitable reaction conditions, occurs without epimerization of starting compounds, giving (R,R)-2-substituted carboxylic acid derivatives.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università "G. D'Annunzio," Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ammazzalorso
authors.forename: R
authors.initials: R
authors.lastname: Amoroso
authors.forename: G
authors.initials: G
authors.lastname: Bettoni
authors.forename: B
authors.initials: B
authors.lastname: Filippis