title: Hemostatic profiles in 39 dogs with congenital portosystemic shunts.
abstract: OBJECTIVE
  To determine if there were significant changes in prothrombin time (PT), partial thromboplastin time (PTT), and fibrinogen levels in dogs with naturally occurring congenital portosystemic shunts (CPSS) and to determine if there was any association between these values, serum albumin concentration, and the ability to attenuate the shunt vessel.
  
  
  METHODS
  Retrospective clinical study.
  
  
  METHODS
  Thirty-nine client-owned dogs.
  
  
  METHODS
  Medical records of 60 dogs with confirmed CPSS were retrospectively evaluated. Hemostatic profiles had been performed before surgery in 39 cases.
  
  
  RESULTS
  Dogs with CPSS had significantly higher values for PTT (P < .001) when compared with normal dogs. Of the total number of dogs, 64.1% had a PTT greater than 16 seconds (25/39). PTT was prolonged by 25% or more in 51.3% of dogs (20/39). PT tended to be higher in dogs with CPSS (P = .036), although only 7.7% (3/39) of dogs had a PT greater than 12 seconds (the maximum reference value). Dogs with CPSS had significantly lower values for albumin and fibrinogen (P < .001). Platelet numbers were within the normal range in 87.2% of cases (34/39). Of the 5 dogs with platelet numbers outside the normal range, 3 were mildly thrombocytopenic. Fibrin degradation product concentrations were not elevated in any dogs tested (N = 22). There was no significant difference in any of the measured variables between dogs with extrahepatic shunts and those with intrahepatic shunts (P > .1). For PT, PTT, albumin, and fibrinogen, there was no significant difference between dogs that underwent total, partial, or no attenuation (P > .3).
  
  
  CONCLUSIONS
  Dogs with CPSS have a tendency to have a prolonged PTT. There was no significant difference in hemostatic profile results between dogs with intrahepatic shunts versus extrahepatic shunts. Preoperative hemostatic profile abnormalities were not useful as predictors of ability to attenuate CPSS.
  
  
  CONCLUSIONS
  Prolonged PTT was not associated with bleeding tendencies in any of the dogs. Assays of individual clotting factors may help to further characterize the abnormalities present in animals with CPSS and may identify specific factor deficiencies. This might enable identification of a noninvasive diagnostic or prognostic indicator.
authors.affiliation: Small Animal Teaching Hospital, The University of Liverpool, England.
authors.forename: J D
authors.initials: JD
authors.lastname: Niles
authors.forename: J M
authors.initials: JM
authors.lastname: Williams
authors.forename: P J
authors.initials: PJ
authors.lastname: Cripps
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006487:Hemostasis; D006975:Hypertension, Portal / Q000097:blood / Q000662:veterinary*; D008297:Male; D010314:Partial Thromboplastin Time / Q000662:veterinary; D011168:Portal System / Q000002:abnormalities*; D011517:Prothrombin Time / Q000662:veterinary; D011996:Records / Q000662:veterinary; D012189:Retrospective Studies
chemical_list: D005340:Fibrinogen