title: Isocapnic hyperventilation increases carbon monoxide elimination and oxygen delivery.
abstract: Hyperventilation with mixtures of O2 and CO2 has long been known to enhance carbon monoxide (CO) elimination at low HbCO levels in animals and humans. The effect of this therapy on oxygen delivery (DO2) has not been studied. Isocapnic hyperventilation utilizing mechanical ventilation may decrease cardiac output and therefore decrease DO2 while increasing CO elimination. We studied the effects of isocapnic hyperventilation on five adult mechanically ventilated sheep exposed to multiple episodes of severe CO poisoning. Five ventilatory patterns were studied: baseline minute ventilation (RR. VT), twice (2. RR) and four times (4. RR) baseline respiratory rate, and twice (2. VT) and four times (4. VT) baseline tidal volume. The mean carboxyhemoglobin (HbCO) washout half-time (t1/2) was 14.3 +/- 1.6 min for RR. VT, decreasing to 9.5 +/- 0.9 min for 2. RR, 8.0 +/- 0.5 min for 2. VT, 6.2 +/- 0.5 min for 4. RR, and 5.2 +/- 0.5 min for 4. VT. DO2 was increased during hyperventilation compared with baseline ventilation for 2. VT, 4. RR, and 4. VT ventilatory patterns. Isocapnic hyperventilation, in our animal model, did not alter arterial or pulmonary blood pressures, arterial pH, or cardiac output. Isocapnic hyperventilation is a promising therapy for CO poisoning.
authors.affiliation: Department of Medicine, University of Washington, Seattle, Washington 98195-6522, USA. kreck@u.washington.edu
authors.forename: T C
authors.initials: TC
authors.lastname: Kreck
authors.forename: E D
authors.initials: ED
authors.lastname: Shade
authors.forename: W J
authors.initials: WJ
authors.lastname: Lamm
authors.forename: S E
authors.initials: SE
authors.lastname: McKinney
authors.forename: M P
authors.initials: MP
authors.lastname: Hlastala
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D002248:Carbon Monoxide / Q000097:blood*; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000628:therapy*; D002263:Carboxyhemoglobin / Q000378:metabolism; D005260:Female; D006207:Half-Life; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D012756:Sheep; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D010100:Oxygen