title: Tissue engineering: current state and prospects.
abstract: Organ shortage and suboptimal prosthetic or biological materials for repair or replacement of diseased or destroyed human organs and tissues are the main motivation for increasing research in the emerging field of tissue engineering. No organ or tissue is excluded from this multidisciplinary research field, which aims to provide vital tissues with the abilities to function, grow, repair, and remodel. There are several approaches to tissue engineering, including the use of cells, scaffolds, and the combination of the two. The most common approach is biodegradable or resorbable scaffolds configured to the shape of the new tissue (e.g. a heart valve). This scaffold is seeded with cells, potentially derived from either biopsies or stem cells. The seeded cells proliferate, organize, and produce cellular and extracellular matrix. During this matrix formation, the starter matrix is degraded, resorbed, or metabolized. First clinical trials using skin or cartilage substitutes are currently under way. Both the current state of the field and future prospects are discussed.
authors.affiliation: Department of Surgery, Harvard Medical School, Massachusetts General Hospital, Center for Innovative Minimally Invasive Therapy, 55 Fruit Street, Boston, Massachusetts 02114, USA. jvacanti@partners.org
authors.forename: U A
authors.initials: UA
authors.lastname: Stock
authors.forename: J P
authors.initials: JP
authors.lastname: Vacanti
mesh_terms: D046508:Culture Techniques / Q000379:methods* / Q000639:trends*; D005544:Forecasting; D006801:Humans; D008567:Membranes, Artificial; D020380:Needs Assessment; D010348:Patient Care Team / Q000458:organization & administration; D012106:Research / Q000458:organization & administration; D009927:Tissue and Organ Procurement / Q000379:methods* / Q000639:trends*
chemical_list: D008567:Membranes, Artificial