Toxoplasmosis.
Recent advances in understanding toxoplasmosis have been made in the areas of the basic biology of the parasite and the host-parasite interaction, especially the cellular immune response. There is new insight into the biology of the cyst stage that is responsible for meat-associated transmission of infection and for the reactivation of disease in chronically infected humans. Fewer recent advances have been made in clinical diagnosis and treatment of toxoplasmosis. The fascinating revelation that Toxoplasma gondii contains an organelle--now known as the apicoplast--that derives from an algal endosymbiont, has opened many avenues of basic investigation. An understanding of the fundamental biology of T. gondii promises future progress in prevention or treatment of toxoplasmosis.
Schwartzman
Joseph D.
JD
Dartmouth Medical School, Dartmouth Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756, USA.