[The expression of nm23-H1 and p53 protein in nasopharyngeal carcinoma].
To evaluate the role of nm23-H1 and p53 protein expression in Nasopharyngeal Carcinoma (NPC), the S-P immunohistochemical method was used to detect the expression of nm23-H1 and p53 protein in 125 cases of NPC.


RESULTS
The positive expression for nm23-H1 and p53 were 50.4%(63/125), 90.4%(113/125), respectively nm23-H1 expression in the NPC with cervical lymph node metastasis and without cervical lymph node metastasis were 27.9%(17/61) and 71.9%(46/64), respectively (P < 0.001).


CONCLUSIONS
1. Mutations of p53 may play a role in carcinogenesis of NPC. 2. The difference between the NPC with cervical lymph node metastasis and without cervical lymph node metastasis for nm23-H1 expression was significant. The nm23-H1 gene may play a role in antimetastasis of NPC.
Zhou
Y
Y
Department of Pathology, Guilin Medical College, Guilin 541001.
Xu
A
A
Ling
X
X
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D016158:Genes, p53; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000096:biosynthesis*; D054778:NM23 Nucleoside Diphosphate Kinases; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009701:Nucleoside-Diphosphate Kinase; D015996:Survival Rate; D014157:Transcription Factors / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins