Antiamnesic effect of acyl-prolyl-containing dipeptide (GVS-111) in compression-induced damage to frontal cortex.
Antiamnestic effect of acyl-prolyl-containing dipeptide GVS-111 was demonstrated in rats with bilateral compression-induced damage to the frontal cortex. Both intraperitoneal and oral administration of the dipeptide improved retrieval of passive avoidance responses in rats with compression-induced cerebral ischemia compared to untreated controls.
Romanova
G A
GA
Institute of General Pathology and Pathophysiology; Institute of Pharmacology; Brain Research Institute, Russian Academy of Medical Sciences, Moscow.parochial@mtu-net.ru
Mirzoev
T K
TK
Barskov
I V
IV
Victorov
I V
IV
Gudasheva
T A
TA
Ostrovskaya
R U
RU
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology*; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D004151:Dipeptides; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly