[Application of comparative genomic hybridization to hyperdiploid acute lymphoblastic leukemia].
OBJECTIVE
To evaluate the implication of comparative genomic hybridization (CGH) in leukemia study.


METHODS
Genomic abnormalities in 14 ALL patients were assayed by CGH, and the results were compared with those of conventional karyotype analysis.


CONCLUSIONS
Regional and/or whole chromosome over-representation was found to be more frequent than under-representation (43 gains versus 6 losses), the most common gains involved being chromosomes 21 and X. Comparison between the results of CGH and conventional R-banding analysis showed that: 1. In 2 cases with trisomy, both the methods gave identical results. 2. In 8 cases, both the results were consistent excepting for minor discrepancies. 3. In 3 cases, including 2 each with triploidy and tetraploidy respectively, and one with chimeric karyotype of normal/+22, the results from the two methods were discrepant.
Cao
Q
Q
Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025.
Wu
Q
Q
Su
X
X
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D004171:Diploidy; D005260:Female; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*