Actin filament nucleation by endosomes, lysosomes and secretory vesicles.
Intracellular pathogens such as Listeria monocytogenes and vaccinia virus propel themselves through the cytoplasm of mammalian cells by nucleating actin filaments. Recently, actin assembly has also been shown to power the movement of intracellular vesicles, and this may be a mechanism underlying endomembrane movement in a variety of physiological contexts. Surprisingly, class I myosins have been found to play important roles in both actin nucleation and endomembrane trafficking.
Taunton
J
J
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA. taunton@cmp.ucsf.edu
D008841:Actin Cytoskeleton / Q000378:metabolism / Q000502:physiology*; D000199:Actins / Q000378:metabolism* / Q000502:physiology*; D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism / Q000502:physiology; D022142:Secretory Vesicles / Q000378:metabolism / Q000502:physiology
D000199:Actins