title: Radical combined treatment of locally extensive head and neck cancer in the elderly.
abstract: OBJECTIVE
  Few studies have described the effects of aggressive combined therapy for locally extensive head and neck cancer in the elderly. Our study evaluated the outcome of this particular cohort of patients after such treatments.
  
  
  METHODS
  Survival, failure, morbidity, and complication rates were determined retrospectively in 43 elderly patients with stage III or IV head and neck cancer who underwent curative surgery and postoperative radiotherapy (n = 33) or neoadjuvant, 3-drug chemotherapy plus radiotherapy (n = 10) between the years 1977 and 1992.
  
  
  RESULTS
  The crude survival rate at 3 years was 27% in patients managed by surgery plus radiotherapy, and 30% in individuals treated with chemoradiation; the corresponding locoregional failure rates were 23% and 30%; and the distant failure rates were 13% and 0%, respectively. The acute toxicity rate was 12% in the surgery plus radiotherapy group and 30% in the chemoradiation patients; the corresponding late complication rates were 0% and 10%. There were no toxic deaths.
  
  
  CONCLUSIONS
  Radical combined treatments can be performed safely and achieve long-term, disease-free survival in selected elderly patients with locally extensive head and neck cancer.
authors.affiliation: Department of Radiology, Louisiana State University School of Medicine, Shreveport 71130, USA.
authors.forename: F L
authors.initials: FL
authors.lastname: Ampil
authors.forename: G M
authors.initials: GM
authors.lastname: Mills
authors.forename: F J
authors.initials: FJ
authors.lastname: Stucker
authors.forename: G V
authors.initials: GV
authors.lastname: Burton
authors.forename: C O
authors.initials: CO
authors.lastname: Nathan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D012189:Retrospective Studies