Protection of the kidney by Wen-Pi-Tang against ischemia-reperfusion injury.
Electrophoretic and densitometric data revealed induction of apoptosis in the kidney due to experimentally induced ischemia-reperfusion injury. Such apoptosis in the kidney was reduced in rats given 62.5 or 125 mg/kg body wt./day Wen-Pi-Tang orally for 30 days prior to ischemia-reperfusion. An increase in the dose of Wen-Pi-Tang was associated with suppressed fragmentation of DNA, a ladder pattern of low-molecular-weight molecules, resulting in a beneficial effect on renal function.
Yokozawa
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T
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan. yokozawa@ms.toyama-mpu.ac.jp
Dong
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Chen
C P
CP
D058186:Acute Kidney Injury / Q000235:genetics / Q000517:prevention & control*; D000284:Administration, Oral; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine; D053938:DNA Fragmentation / Q000187:drug effects*; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000235:genetics / Q000517:prevention & control*
D004365:Drugs, Chinese Herbal; D003404:Creatinine