title: Behavioral peculiarities and reactions of brain dopaminergic systems in rats with different resistance to acute hypobaric hypoxia.
abstract: Locomotor activity in the open field test did not correlate with rat resistance to acute hypobaric hypoxia; there was a correlation between this resistance and rat behavior during acute stress. Immobility was characteristic of rats with low and particularly medium resistance to hypoxia; this reaction can be abolished by antidepressants. by contrast, highly resistant rats were mainly hyperactive. The resistance to hypoxia was associated with extreme parameters of dopaminergic neuron functioning. In low-resistant rats locomotor stereotypia was maximal, while perioral stereotypia was the minimal; highly resistant rats were characterized by an opposite pattern, and medium-resistant rats occupied an intermediate position.
authors.affiliation: Laboratory of Bioenergetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
authors.forename: N A
authors.initials: NA
authors.lastname: Bondarenko
authors.forename: E L
authors.initials: EL
authors.lastname: Germanova
authors.forename: L D
authors.initials: LD
authors.lastname: Luk'yanova
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004924:Escape Reaction; D000860:Hypoxia / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*
chemical_list: D011954:Receptors, Dopamine; D004298:Dopamine