Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides.
This study describes the antinociceptive activity of some N-aryl-glutaramic acids and N-aryl-glutarimides in writhing and formalin tests, two classical models of pain in mice. These compounds show high activity, being more active than acetyl salycilic acid, acetaminophen and indomethacin, used as standard drugs for comparison. The introduction of different substituent groups in the aromatic ring caused a significant change in activity. The results obtained here are promising from a pharmacological point of view, since these simple compounds might be used as models to obtain new and potent analgesic drugs.
Stiz
D S
DS
Núcleo de Investigações Químico-Farmacêuticas (NIQFAR)/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí-SC, Brasil.
Souza
M M
MM
Golin
V
V
Neto
R A
RA
Corrêa
R
R
Nunes
R J
RJ
Yunes
R A
RA
Cechinel-Filho
V
V
D019342:Acetic Acid; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D005557:Formaldehyde; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction / Q000187:drug effects; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control; D010147:Pain Measurement / Q000187:drug effects; D010881:Piperidones / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000700:Analgesics; D010881:Piperidones; D005557:Formaldehyde; D018698:Glutamic Acid; D019342:Acetic Acid; D001241:Aspirin; D007213:Indomethacin