[Analysis on associations of cytochrome P450 1A1-Hinc II and glutathion S-transferase-theta with primary dysmenorrhea].
OBJECTIVE
To investigate the genetic susceptibility to primary dysmenorrhea.


METHODS
Data of 499 female workers in a textile mill were collected. The associations of cytochrome P450 1A1-Hinc II(CYP 1A1-Hinc II) and glutathion S-transferase-theta(GSTT1) polymorphisms with heavy primary dysmenorrhea were evaluated by Logistic regression, with adjustment for potential confounders.


RESULTS
The result showed variant of CYP1A1- Hinc II genotypes slightly reduced the risk of primary dysmenorrhea, but its OR value was not statistically significant (CYP1A1-Hinc II:OR=0.64, 95% CI 0.35-1.17). The GSTT1 genotype variant increased the risk of primary dysmenorrhea (GSTT1:OR=1.83, 95% CI 1.04-3.21). After potential confounders were adjusted, the data showed that CYP1A1-Hinc II variant had the trend of decreasing the risk of dysmenorrhea (CYP1A1-Hinc II:OR=0.58, 95% CI 0.31-1.08), but its decreasing scope was still not statistically significant. The GSTT1 variant genotypes showed a significantly increased risk of dysmenorrhea (GSTT1:OR=2.01, 95% CI 1.12-3.62).


CONCLUSIONS
The results suggested that GSTT1 polymorphism be associated with heavy primary dysmenorrhea.
Wu
D
D
The Biomedical Institute of Anhui Medical University, Hefei, Aihui, 230032 P.R. China. ppgamu@mail.hf.ah.cn
Chen
D
D
Liu
X
X
Ni
J
J
Jin
Y
Y
Xu
X
X
D000328:Adult; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004412:Dysmenorrhea / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
D019363:Cytochrome P-450 CYP1A1; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase