title: [Effects of non-focused ultrasound on the cochlea in guinea pigs].
abstract: Guinea pigs with normal preyer's reflex were researched for the morphological and the enzymatic change of cochlea under the influence of 2.5 MHz, 8 MHz non-focused ultrasound irradiation for 3 hours or 6 hours. The results showed that no histopathological changes could be found. But enzyme histochemistry studies showed that 2.5 MHz or 8 MHz non-focused ultrasound irradiation for 6 hours has led to enervation of SDH activity and enhancement of LDH activity of hair cells in the 0.87 +/- 0.20 or 0.80 +/- 0.20 mm areas of the second circle or the first circle respectively. The results suggest that the non-focused ultrasound irradiation for some dose may cause special injury of cochlear hair cells.
authors.affiliation: Department of Otorhinolaryngolgy, Union Hospital of Tongji Medical University, Wuhan, 430022.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000000981:diagnostic imaging / Q000201:enzymology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D013385:Succinate Dehydrogenase / Q000378:metabolism*; D014465:Ultrasonics; D014463:Ultrasonography
chemical_list: D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase