title: Long-term results of a phase-II-pilot trial on preoperative high-dose chemotherapy with stem cell rescue in patients with cancer of the upper gastrointestinal tract.
abstract: We have tested the feasibility, tolerability, and efficacy of a multimodality treatment approach for patients with locally advanced cancer of the upper gastrointestinal tract including preoperative chemotherapy with the EAP-protocol as induction and a consecutive high-dose chemotherapy with MCVB and autologous stem cell rescue for responding patients. This first pilot trial in 16 patients shows that the approach is feasible with tolerable toxicity and can lead to prolonged disease-free survival in responding patients.
authors.affiliation: Department of Medicine/Hematology and Oncology, University Hospital, Westfaelische Wilhelms Universitaet Muenster, D-48149 Muenster, Germany. berdel@uni-muenster.de
authors.forename: W E
authors.initials: WE
authors.lastname: Berdel
authors.forename: T
authors.initials: T
authors.lastname: Heldmann
authors.forename: E
authors.initials: E
authors.lastname: Thiel
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D002330:Carmustine / Q000008:administration & dosage; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects; D009367:Neoplasm Staging; D010865:Pilot Projects; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D017741:Survivors; D013997:Time Factors; D014182:Transplantation, Autologous
chemical_list: D016685:Mitomycin; D002945:Cisplatin; D002330:Carmustine