Polymorphism in regulatory gene sequences.
The extensive polymorphism revealed in non-coding gene-regulatory sequences, particularly in the immune system, suggests that this type of genetic variation is functionally and evolutionarily far more important than has been suspected, and provides a lead to new therapeutic strategies.
Mitchison
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Department of Immunology, Windeyer Institute of Medical Science, University College London Medical School, Cleveland Street, London W1P 6DB, UK. n.mitchison@ucl.ac.uk
D000818:Animals; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D011110:Polymorphism, Genetic; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*