Effect of quinapril on intimal hyperplasia after coronary stenting as assessed by intravascular ultrasound.
We studied whether angiotensin-converting enzyme inhibition with quinapril treatment can prevent in-stent restenosis after successful implantation of Palmaz-Schatz stents. Intravascular ultrasound study, but not quantitative coronary angiography analysis, revealed that quinapril treatment significantly prevented the loss of both minimal lumen cross-sectional area and lumen volume in stents, in addition to reducing the increase in intimal hyperplasia volume.
Kondo
J
J
Department of Cardiology, Ogaki Municipal Hospital, Japan.
Sone
T
T
Tsuboi
H
H
Mukawa
H
H
Kosokabe
T
T
Tsuzuki
M
M
Tomida
T
T
Suzuki
T
T
Kamiya
H
H
Hayashi
K
K
Matsui
H
H
Okumura
K
K
D000368:Aged; D000800:Angioplasty, Balloon; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000517:prevention & control* / Q000628:therapy; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000517:prevention & control; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D000077583:Quinapril; D012008:Recurrence; D015607:Stents; D044005:Tetrahydroisoquinolines; D016896:Treatment Outcome; D017539:Tunica Intima / Q000473:pathology*; D018084:Ultrasonography, Interventional; D014743:Videotape Recording
D000806:Angiotensin-Converting Enzyme Inhibitors; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077583:Quinapril