title: Can we replace the 90-minute thrombolysis in myocardial infarction (TIMI) flow grades with those at 60 minutes as a primary end point in thrombolytic trials? TIMI Study Group.
abstract: The establishment of patency (Thrombolysis In Myocardial Infarction [TIMI] grade 2 or 3 flow) and/or TIMI grade 3 flow at 60 minutes after thrombolytic administration is both a univariate and multivariate predictor of in-hospital and 30-day mortality, and the odds ratios for mortality are nearly identical for TIMI grade 3 flow at 60 and 90 minutes. Thus, the 60-minute angiographic end point appears to be a valid alternative to that at 90 minutes and may permit earlier decisions regarding post-thrombolytic intervention.
authors.affiliation: Department of Medicine, The University of California San Francisco, 94118, USA. mgibson@perfuse.org
authors.forename: C M
authors.initials: CM
authors.lastname: Gibson
authors.forename: S A
authors.initials: SA
authors.lastname: Murphy
authors.forename: S J
authors.initials: SJ
authors.lastname: Marble
authors.forename: C H
authors.initials: CH
authors.lastname: McCabe
authors.forename: E M
authors.initials: EM
authors.lastname: Antman
authors.forename: C P
authors.initials: CP
authors.lastname: Cannon
authors.forename: E
authors.initials: E
authors.lastname: Braunwald
mesh_terms: D017023:Coronary Angiography; D017052:Hospital Mortality; D006801:Humans; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D016019:Survival Analysis; D015912:Thrombolytic Therapy; D013997:Time Factors; D016896:Treatment Outcome; D014654:Vascular Patency