Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract.
Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and Crohn's disease (CD).
Pages
F
F
Laboratoire Universitaire de Transfert en Immunologie, Universités Paris V, Paris VI/Laboratorie Pierre Fabre, France. frank.pages@cochin.univ-paris5.fr
Berger
A
A
Lebel-Binay
S
S
Zinzindohoue
F
F
Danel
C
C
Piqueras
B
B
Carriere
O
O
Thiounn
N
N
Cugnenc
P H
PH
Fridman
W H
WH
D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D003424:Crohn Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D020382:Interleukin-18 / Q000096:biosynthesis* / Q000737:chemistry / Q000502:physiology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism
D020382:Interleukin-18