title: Azithromycin and gentamicin therapy for the treatment of humans with brucellosis.
abstract: Ten patients with brucellosis were treated with azithromycin and gentamicin to assess the treatment's safety and efficacy. Seven patients had an excellent therapeutic response at the end of therapy; however, relapse was noted in 3. When relapse was considered in combination with an initial lack of efficacy, 5 patients (50%; 95% confidence interval, 18.7%-81.3%) did not respond to therapy; these results do not favor the use of azithromycin to treat brucellosis in humans.
authors.affiliation: Unit of Infectious Diseases, Service of Internal Medicine, Hospital General, Albacete, Spain. jsolera@chospab.es
authors.forename: J
authors.initials: J
authors.lastname: Solera
authors.forename: J L
authors.initials: JL
authors.lastname: Beato
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Alfaro
authors.forename: J C
authors.initials: JC
authors.lastname: Segura
authors.forename: E
authors.initials: E
authors.lastname: de Tomas
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017963:Azithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D002006:Brucellosis / Q000188:drug therapy*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012449:Safety; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D017963:Azithromycin