No association between apolipoprotein E polymorphisms and general cognitive ability in children.
In this work we explored the hypothesis that variation in the gene encoding apolipoprotein E (ApoE) is a factor modifying general cognitive ability (g). A case control sample of 101 high g and 101 average g children was scored for ApoE genotypes and two variants in the transcriptional regulatory region of the gene (Th1/E47cs and -491 AT). No evidence of association between these polymorphisms and g was found. We conclude that variation at these loci is not a factor with a measurable impact on general cognitive ability in the healthy population.
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Neuropsychiatric Genetics Unit, Psychological Medicine, Tenovus Building, Heat Park, UWCM, Cardiff CF14 4XN, UK.
Fisher
P J
PJ
Plomin
R
R
Owen
M J
MJ
D000293:Adolescent; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D001921:Brain / Q000254:growth & development* / Q000378:metabolism; D001923:Brain Chemistry / Q000235:genetics*; D002648:Child; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000235:genetics* / Q000503:physiopathology; D004252:DNA Mutational Analysis; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D007360:Intelligence / Q000235:genetics* / Q000502:physiology; D011110:Polymorphism, Genetic / Q000235:genetics*
D001057:Apolipoproteins E