Ankyrins and cellular targeting of diverse membrane proteins to physiological sites.
Ankyrins are spectrin-binding proteins that associate via ANK repeats with a variety of ion channels/pumps, calcium release channels and cell adhesion molecules. Recent studies in mice indicate that ankyrins have a physiological role in restricting voltage-gated sodium channels and members of the L1 CAM family of cell adhesion molecules to excitable membranes in the central nervous system and in targeting calcium-release channels to the calcium homeostasis compartment of striated muscle.
Bennett
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Howard Hughes Medical Institute and the Departments of Cell Biology and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA. benne012@mc.duke.edu
Chen
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D000818:Animals; D017487:Ankyrins / Q000737:chemistry / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology; D019143:Evolution, Molecular; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D017487:Ankyrins; D008565:Membrane Proteins