Signal transduction. An arresting start for MAPK.
Exactly how signaling proteins know where they need to be in the cell is one of the intriguing mysteries of signal transduction biology. In a Perspective, Pouysségur reviews new results that identify b-arrestin 2 as a scaffolding protein that holds together the different components of a MAPK signaling pathway that activates the transcription factor kinase, JNK3.
Pouysségur
J
J
Institute of Signaling, Developmental Biology and Cancer Research, CNRS-UMR 6543, Nice 06189, France. pouysseg@unice.fr
D000818:Animals; D019390:Arrestins / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D004789:Enzyme Activation; D048031:JNK Mitogen-Activated Protein Kinases; D048688:MAP Kinase Kinase 7; D048848:MAP Kinase Kinase Kinase 5; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism; D020935:MAP Kinase Signaling System; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048057:Mitogen-Activated Protein Kinase 10; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008954:Models, Biological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D044140:Receptor, Angiotensin, Type 1; D044464:Receptor, PAR-2; D011945:Receptors, Angiotensin / Q000378:metabolism; D018179:Receptors, Thrombin / Q000378:metabolism; D000071557:beta-Arrestins
D019390:Arrestins; D016755:Proto-Oncogene Proteins c-jun; D044140:Receptor, Angiotensin, Type 1; D044464:Receptor, PAR-2; D011945:Receptors, Angiotensin; D018179:Receptors, Thrombin; D000071557:beta-Arrestins; D048057:Mitogen-Activated Protein Kinase 10; D011505:Protein-Tyrosine Kinases; D048031:JNK Mitogen-Activated Protein Kinases; D019950:Mitogen-Activated Protein Kinase 1; D020928:Mitogen-Activated Protein Kinases; D048848:MAP Kinase Kinase Kinase 5; D020930:MAP Kinase Kinase Kinases; D048688:MAP Kinase Kinase 7; D020929:Mitogen-Activated Protein Kinase Kinases