Plasma lipids and urinary albumin excretion rate in Type 1 diabetes mellitus: the EURODIAB IDDM Complications Study.
OBJECTIVE
To examine the relationship between increased urinary albumin excretion rate and fasting plasma lipids among male and female respondents to the EURODIAB IDDM Complications Study, and attempt to explain inconsistencies in previous reports.


METHODS
A cross-sectional study of 3250 randomly selected Type 1 diabetic patients from 31 diabetes clinics in 16 European countries was carried out between 1989 and 1990. Plasma lipids and urinary albumin were measured centrally. The present analysis was confined to the subgroup of 2205 patients attending after a 10-12 h overnight fast. Mean age was 33 years (SD 10) and mean duration of Type 1 diabetes mellitus was 15 years (SD 9).


RESULTS
The prevalence of microalbuminuria (24-h urinary albumin excretion rate 20-200 microg/min) was 21.7% (95% confidence interval 19.9-23.5) and macroalbuminuria (24-h urinary albumin excretion rate > 200 microg/min) 7.8% (6.6-9.0). In comparison to patients with normal urinary albumin excretion rate (< 20 microg/min), and after controlling for age, sex, glycaemic control, duration of diabetes and current smoking, macroalbuminuria was associated with significantly (P<0.01) increased fasting plasma triglycerides, cholesterol, LDL-cholesterol, cholesterol:HDL-cholesterol ratio and, in women, reduced HDL-cholesterol. In men and women with microalbuminuria, the only significant association was with increased plasma triglycerides.


CONCLUSIONS
These data confirm that there is an association between fasting plasma lipids and increasing urinary albumin excretion rate in European Type 1 diabetic patients. In microalbuminuric patients, however, the association was weaker than previously reported and partly explained by confounding factors.
Mattock
M B
MB
South-West Thames Institute for Renal Research, St. Helier Hospital, Carshalton, UK.
Cronin
N
N
Cavallo-Perin
P
P
Idzior-Walus
B
B
Penno
G
G
Bandinelli
S
S
Standl
E
E
Kofinis
A
A
Fuller
J H
JH
D000328:Adult; D017668:Age of Onset; D000419:Albuminuria / Q000453:epidemiology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D015897:Comorbidity; D016001:Confidence Intervals; D003401:Creatine / Q000097:blood; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D003925:Diabetic Angiopathies / Q000453:epidemiology; D005060:Europe; D005215:Fasting; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D008597:Menstrual Cycle; D015995:Prevalence; D012907:Smoking; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D003401:Creatine