title: The effect of lumbar sympathectomy on increased tactile sensitivity in spinal nerve ligated rats.
abstract: The aim of this study was to investigate the reason for the contradictory results following surgical sympathectomy on increased tactile sensitivity in spinal nerve ligated rats. For this purpose, firstly the results of L5 spinal nerve ligation alone and both L5 and L6 (L5/6) spinal nerve ligation were compared in Sprague-Dawley rats. Secondly, the difference in tactile sensitivity between the plantar surface (the middle glabrous area on the foot pads of the hind paw) and on the toe (the proximal half of the third and fourth toe of the hind paw) after the spinal nerve injury was studied. Third, we divided the L5 spinal nerve ligated rats into two groups, (i.e. low and high threshold groups) based on the degree of tactile sensitivity and investigated the effect of surgical lumbar sympathectomy (L2-L5) on tactile sensitivity in both the plantar and toe areas. The results show that the tactile sensitivities of L5 spinal nerve ligated rats and L5/6 spinal nerve ligated rats were not different. However, tactile sensitivities of the plantar surface were less than those of toe area suggesting that the response from toe is a better indicator of neuropathic pain. Surgical sympathectomy reduced the response from only the toe area and only in the low threshold group. These results suggest that the reason for the contradictory results of surgical sympathectomy in spinal nerve ligation models is, at least in part, the difference in the degree of mechanical allodynia in each study.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA. dlee4@prius.jnj.com
authors.forename: D H
authors.initials: DH
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Katner
authors.forename: S
authors.initials: S
authors.lastname: Iyengar
authors.forename: D
authors.initials: D
authors.lastname: Lodge
mesh_terms: D000818:Animals; D006930:Hyperalgesia / Q000503:physiopathology*; D008026:Ligation; D008160:Lumbosacral Plexus / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D009437:Neuralgia / Q000503:physiopathology; D017288:Pain Threshold / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013562:Sympathectomy; D014110:Touch / Q000502:physiology*