An HphI polymorphism in the E-selectin gene is associated with premature coronary artery disease.
An increased expression of E-selectin has been observed in the arterial endothelium interacting with lymphocytes and macrophages in human atherosclerotic lesions. We examined whether a polymorphism in the E-selectin gene, due to a G to T mutation (G98T) in the untranslated region of exon 2, was associated with premature coronary artery disease (CAD). Other lipid and nonlipid risk factors including a Ser to Arg (S128R) substitution in the E-selectin gene were also assessed. In patients with premature CAD (men < or = 45 years old and women < or =55 years old, N = 51) who underwent an elective diagnostic coronary arteriography, the frequency of the mutation was significantly higher than in controls (N = 50, 0.22 vs. 0.10, p = 0.024). After controlling for other CAD risk factors (plasma total cholesterol, triglyceride, LDL-apolipoprotein B. cigarette smoking and the S128R mutation) by multiple logistic analysis, the G98T mutation in the E-selectin gene was still a significant predictor of premature CAD [p = 0.022, odds ratio (95%, CI)= 3.58 (1.20-10.67)].
Zheng
F
F
Lipid Research Atherosclerosis Division, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Chevalier
J A
JA
Zhang
L Q
LQ
Virgil
D
D
Ye
S Q
SQ
Kwiterovich
P O
PO
D000483:Alleles; D001053:Apolipoproteins / Q000097:blood; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000235:genetics*; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000737:chemistry; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D019040:E-Selectin / Q000235:genetics*; D005787:Gene Frequency; D005998:Glycine / Q000737:chemistry; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011859:Radiography; D012307:Risk Factors; D013912:Threonine / Q000737:chemistry; D044465:White People
D001053:Apolipoproteins; D017931:DNA Primers; D019040:E-Selectin; D008055:Lipids; D013912:Threonine; D015252:Deoxyribonucleases, Type II Site-Specific; C024412:GGTGA-specific type II deoxyribonucleases; D005998:Glycine