title: Nodularin-Har: a new nodularin from Nodularia.
abstract: A cyanobacterial hepatotoxin, nodularin-Har, having a homoarginine instead of an arginine in nodularin, was isolated from Nodularia PCC7804. The structure was elucidated as 1 on the basis of 2D NMR and FABMS. The LD(50) (mouse ip) value of 1 was 70 microg/kg.
authors.affiliation: School of Marine Science and Technology, Tokai University, 3-20-1 Orido, Shimizu, Shizuoka 424-8610, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Saito
authors.forename: A
authors.initials: A
authors.lastname: Konno
authors.forename: H
authors.initials: H
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: F
authors.initials: F
authors.lastname: Nishida
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: C
authors.initials: C
authors.lastname: Chen
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D000087522:Cyanobacteria Toxins; D008401:Gas Chromatography-Mass Spectrometry; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000633:toxicity; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000087522:Cyanobacteria Toxins; D010456:Peptides, Cyclic; C428197:nodularin-Har