Allergen-containing drug from Malassezia spp. yeast.
Malassezia spp. yeast habituating the skin of healthy humans can be a source of allergens for patients with atopic dermatitis. We proposed a method for obtaining allergen-containing preparation by trimming outer cell wall proteins with 1% sodium dodecyl sulfate. The resultant preparation contained 36 and 67 kD proteins known as Malassezia allergens. IgE antibodies to these proteins were detected in the sera of young people with atopic dermatitis.
Arzumanyan
V G
VG
Institute of Microbiology, Russian Academy of Sciences, Moscow, Russia. veraar@hotmail.com
Bykova
S A
SA
Serdyuk
O A
OA
Kozlova
N N
NN
D000328:Adult; D000485:Allergens / Q000276:immunology / Q000302:isolation & purification*; D000946:Antigens, Fungal / Q000276:immunology / Q000302:isolation & purification*; D002473:Cell Wall; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology / Q000382:microbiology; D005656:Fungal Proteins / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008290:Malassezia / Q000737:chemistry* / Q000276:immunology; D012967:Sodium Dodecyl Sulfate
D000485:Allergens; D000946:Antigens, Fungal; D005656:Fungal Proteins; D012967:Sodium Dodecyl Sulfate