Use of dermal-like tissue in the management of chronic and acute full-thickness cutaneous wounds.
This paper presents a dermal replacement technique for cutaneous wounds of diverse origin. An autologous tissue-engineered dermal-like structure was implanted in one patient with an acute surgical excision of a nevus and in another patient with a chronic post-traumatic ulcer. The dermal constructs were well integrated with the wound area, and, at 3 weeks, an epidermal covering was implanted. In both cases, 3 to 8 weeks after autografting, good integration of the transplanted epidermis with the surrounding native skin and a good take over the dermal-like tissue occurred. The use of this technology, despite its high cost, is increasing. Clinicians choose it because it helps heal critical wounds for which current therapies have failed.
Brun
P
P
Institute of Histology and Embryology, Faculty of Medicine, University of Padova, Italy.
Grosso
F
F
Galassi
G
G
Radice
M
M
Tonello
C
C
Cortivo
R
R
Abatangelo
G
G
D000208:Acute Disease; D000293:Adolescent; D002908:Chronic Disease; D005347:Fibroblasts / Q000166:cytology / Q000637:transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000601:surgery*; D016038:Skin Transplantation / Q000379:methods*; D014947:Wounds and Injuries / Q000601:surgery*