Protein kinase C inhibitors attenuate protective effect of high glucose against hypoxic injury in H9c2 cardiac cells.
In this study, we demonstrated that PKC inhibitors significantly attenuated the cardioprotective effect produced by high-glucose (22 mM) treatment for 48 h against hypoxic injury in H9c2 cardiac cells. PKC activators mimicked the cardioprotective effect of high glucose. These results suggest a possible role of PKC activation in high-glucose--induced protection.
Moon
C H
CH
Department of Physiology, School of Medicine, Ajou University, Suwon 442-749, Korea.
Jung
Y S
YS
Kim
M H
MH
Park
R M
RM
Lee
S H
SH
Baik
E J
EJ
D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects*; D002460:Cell Line; D004336:Drug Antagonism; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D011493:Protein Kinase C; D005947:Glucose