Embryotoxicity and teratogenicity studies of an ayurvedic contraceptive--pippaliyadi vati.
An ayurvedic contraceptive--pippaliyadi vati, containing equal parts of powdered seeds or fruit berries of Embelia ribes, fruit of Piper longum and borax powder was fed orally to two groups of pregnant rats: 2.5 times to one and five times to the other; the recommended dose for humans. The foetuses of mothers fed with pippaliyadi had low birth weights and were smaller in length. The mothers gained less weight during gestation. Developmental defects of soft tissues and skeletons were analyzed. There were instances of herniation of the intestines into the umbilical cord in foetuses of mothers who were administered pippaliyadi. The control and the gum acacia groups did not show such herniation.
Chaudhury
M R
MR
Division of Toxicology, National Institute of Immunology, Aruna Asaf Ali Marg, 110067, New Delhi, India.
Chandrasekaran
R
R
Mishra
S
S
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D001842:Bone and Bones / Q000473:pathology; D003276:Contraceptives, Oral / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D004622:Embryo, Mammalian / Q000473:pathology*; D005260:Female; D005333:Fetus / Q000473:pathology; D005638:Fruit / Q000737:chemistry; D006552:Hernia, Inguinal / Q000139:chemically induced / Q000151:congenital; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D012639:Seeds / Q000737:chemistry; D013723:Teratogens / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
D003276:Contraceptives, Oral; D010936:Plant Extracts; D013723:Teratogens