title: Fats, lipids and blood coagulation.
abstract: Saturated and n-3 fatty acids, postprandial lipaemia, and the combined effects of fatty acids and lipid-lowering drugs have been of principal interest in recent studies in the field of dietary fats, lipids and haemostasis. The sex-specific effect of individual saturated fatty acids on coagulation factor VII activity has been discovered, and the significant effect of factor VII R353Q polymorphism on the postprandial response has also been found. An increased intake of n-3 fatty acids or fat reduction when combined with intensive lifestyle interventions may lead to reduced thrombotic potential in type 2 diabetic patients and obese individuals. Furthermore, positive effects on haemostasis by combined treatment with long-chain n-3 fatty acids and simvastatin indicate that n-3 fatty acids may be of some relevance with lipid-lowering drugs. The possible unfavourable effect of n-3 fatty acids on plasminogen activator inhibitor-1 activity is still a matter of dispute, but recent studies suggest that n-3 fatty acids, including alpha-linolenic acid, may have antithrombotic effects by enhancing protein C activity.
authors.affiliation: Department of Applied Chemistry and Microbiology (Nutrition), University of Helsinki, Helsinki, Finland. marja.mutanen@helsinki.fi
authors.forename: M
authors.initials: M
authors.lastname: Mutanen
authors.forename: R
authors.initials: R
authors.lastname: Freese
mesh_terms: D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage*; D015444:Exercise; D005215:Fasting; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005260:Female; D005342:Fibrinolysis; D005502:Food; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008055:Lipids / Q000097:blood*; D008297:Male
chemical_list: D001779:Blood Coagulation Factors; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D000960:Hypolipidemic Agents; D008055:Lipids