title: Enantioselective addition of a chiral thiazolidinethione-derived titanium enolate to acetals.
abstract: [reaction: see text] High stereoselectivities (up to 98% de) have been achieved for the Lewis acid-mediated cross-coupling reaction of dimethyl acetals to a chiral 1,3-thiazolidine-2-thione-derived titanium enolate. The reaction affords enantiopure anti alpha-methyl-beta-alkoxy carbonyl compounds in a wide range of acetals.
authors.affiliation: Departaments de Química Orgànica and Cristal.lografia, Mineralogia i Dipòsits Minerals, Universitat de Barcelona, Catalonia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Cosp
authors.forename: P
authors.initials: P
authors.lastname: Romea
authors.forename: P
authors.initials: P
authors.lastname: Talavera
authors.forename: F
authors.initials: F
authors.lastname: Urpí
authors.forename: J
authors.initials: J
authors.lastname: Vilarrasa
authors.forename: M
authors.initials: M
authors.lastname: Font-Bardia
authors.forename: X
authors.initials: X
authors.lastname: Solans