title: Scale-up of filamentous organisms from tubes and shake-flasks into stirred vessels.
abstract: The choice of small-scale fermentation systems contributes significantly to a successful scale-up. Creasing of flasks and the chosen shaker parameters influence the production of secondary metabolites in a strain- and even compound-specific manner. Using actinomycetes and fungi as model organisms the influence of the small-scale fermentation system on the production of various secondary metabolites is described and the effects on screening success and scale-up are considered.
authors.affiliation: TerraGen Discovery (UK) Ltd., Slough, UK
authors.forename: W
authors.initials: W
authors.lastname: Katzer
authors.forename: M
authors.initials: M
authors.lastname: Blackburn
authors.forename: K
authors.initials: K
authors.lastname: Charman
authors.forename: S
authors.initials: S
authors.lastname: Martin
authors.forename: J
authors.initials: J
authors.lastname: Penn
authors.forename: S
authors.initials: S
authors.lastname: Wrigley