Repulsive factors and axon regeneration in the CNS.
During the past year, a major advance in the study of axon regeneration was the molecular cloning of Nogo. The expression of Nogo protein by CNS myelin may be a major factor in the failure of CNS axon regeneration. The effect of disrupting Nogo-dependent axon inhibition can now be studied conclusively. In related work, immunization with a Nogo-containing CNS myelin preparation was shown to promote regeneration and dramatic functional recovery after spinal cord trauma.
Fournier
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AE
Department of Neurology and Section of Neurobiology, Yale University School of Medicine, PO Box 208018, New Haven, Connecticut 06520, USA.
Strittmatter
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SM
D001369:Axons / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D006801:Humans; D009185:Myelin Proteins / Q000502:physiology; D009186:Myelin Sheath / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D000070798:Nogo Proteins
D009185:Myelin Proteins; D009414:Nerve Growth Factors; D000070798:Nogo Proteins; C000603199:RTN4 protein, human