title: BCG immunotherapy: be cautious of granulomas. Disseminated BCG infection and mycotic aneurysm as late complications of intravesical BCG instillations.
abstract: We describe a 65-year-old man with a granulomatous hepatitis and a progressive mycotic aneurysm of the abdominal aorta. One year before he received intravesical bacillus Calmette--Guérin (BCG) for carcinoma of the bladder without any complaints. Only post-mortem investigations could confirm that he suffered from a systemic BCG infection. Literature is reviewed for this rare complication.
authors.affiliation: Department of Internal Medicine, St. Elisabeth Hospital, P.O. Box 90151, 5000 LC Tilburg, The Netherlands. interezt@wxs.nl
authors.forename: J T
authors.initials: JT
authors.lastname: Kamphuis
authors.forename: A G
authors.initials: AG
authors.lastname: Buiting
authors.forename: J F
authors.initials: JF
authors.lastname: Miseré
authors.forename: D P
authors.initials: DP
authors.lastname: van Berge Henegouwen
authors.forename: D
authors.initials: D
authors.lastname: van Soolingen
authors.forename: P L
authors.initials: PL
authors.lastname: Rensma
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000382:microbiology* / Q000601:surgery; D001500:BCG Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D004269:DNA, Bacterial; D017809:Fatal Outcome; D006101:Granuloma, Giant Cell / Q000382:microbiology*; D006505:Hepatitis / Q000382:microbiology*; D006801:Humans; D016233:Immunotherapy, Active / Q000009:adverse effects; D007322:Instillation, Drug; D008297:Male; D009163:Mycobacterium bovis / Q000302:isolation & purification / Q000472:pathogenicity*; D012150:Polymorphism, Restriction Fragment Length; D001749:Urinary Bladder Neoplasms / Q000628:therapy
chemical_list: D001500:BCG Vaccine; D004269:DNA, Bacterial