Trisomy 14 in myeloid malignancies: report of two cases and review of the literature.
To our knowledge, 58 cases of trisomy 14 in association with hematological malignancies have been reported, predominantly in myeloid malignancies. We report two patients with trisomy 14 associated with myelodysplasia. The bone marrow showed trilineage dysplasia, monocytosis and only mild thrombocytopenia. A nonmosaic karyotype was seen in both patients and survival from diagnosis was short (<1 year). The features are consistent with data from other published cases and support the hypothesis that trisomy 14 is a non-random karyotypic abnormality, with defined clinical associations and a poor prognosis.
Horton
Y M
YM
University of Edinburgh, Leukaemia Research Fund, John Hughes Bennett Laboratory, Department of Oncology, Edinburgh, UK.
Johnson
P R
PR
D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D001854:Bone Marrow Cells / Q000473:pathology*; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D014314:Trisomy