title: Temperature quantitation and mapping of frozen tissue.
abstract: A method was developed for quantitating the temperature within frozen tissue with the magnetic resonance (MR) parameter R2*. The pulse sequence uses half-pulse excitation and a short spiral readout to achieve echo times as short as 0.2 msec. Fiber-optic temperature sensors were inserted into bovine liver tissue. The tissue was frozen at one end while being held warm at the other end. Once steady state was reached, the parameter R2* was measured. A linear dependence of R2* on temperature was demonstrated. R2* is independent of freeze number and of the orientation of the temperature gradient with respect to the main magnetic field. Feasibility in a canine prostate during cryosurgery is demonstrated. J. Magn. Reson. Imaging 2001;13:99-104.
authors.affiliation: Department of Radiology, Stanford University, Stanford, California, USA. kim@lucas.stanford.edu
authors.forename: K
authors.initials: K
authors.lastname: Butts
authors.forename: J
authors.initials: J
authors.lastname: Sinclair
authors.forename: B L
authors.initials: BL
authors.lastname: Daniel
authors.forename: J
authors.initials: J
authors.lastname: Wansapura
authors.forename: J M
authors.initials: JM
authors.lastname: Pauly
mesh_terms: D000818:Animals; D001831:Body Temperature; D002417:Cattle; D003452:Cryosurgery; D004285:Dogs; D005336:Fiber Optic Technology / Q000295:instrumentation; D005615:Freezing; D008099:Liver; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D055100:Optical Fibers; D011467:Prostate / Q000601:surgery; D013821:Thermometers