title: Genetics of anesthetic response: autosomal mutations that render Drosophila resistant to halothane.
abstract: Molecular mechanisms of anesthetic action are poorly understood. Genetic approaches to investigate mechanisms of anesthesia, although sparse and rather new, are turning out to be informative and add a new perspective. Before beginning a systematic investigation of anesthesia by this approach, it is necessary to have at hand a large collection of mutations in different loci that alter anesthetic response. We report here the isolation and characterization of six mutant autosomal lines that show a decreased sensitivity to the inhalation of anesthetic halothane. Two of these mutations, Omar(82) and Qajjem(211) are shown to map to separate loci on the third chromosome.
authors.affiliation: Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, Mumbai 400 005, India.
authors.forename: M C
authors.initials: MC
authors.lastname: Madhavan
authors.forename: R A
authors.initials: RA
authors.lastname: Kumar
authors.forename: K S
authors.initials: KS
authors.lastname: Krishnan
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002874:Chromosome Mapping; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D005824:Genetics, Behavioral / Q000187:drug effects; D006221:Halothane / Q000494:pharmacology*; D008297:Male; D016296:Mutagenesis / Q000187:drug effects* / Q000235:genetics; D010641:Phenotype
chemical_list: D018685:Anesthetics, Inhalation; D006221:Halothane