title: Modern methods for diagnosis and monitoring of nephrotoxicity during antitumor therapy with platinum derivatives.
abstract: Chemotherapy is an important method of antitumor therapy. Nephrotoxicity characteristic of many cytostatics, including platinum compounds, is a serious complication limiting the drug dose [4,5,7-9]. Platinum derivatives, in particular, cisplatin, are drugs of choice in the treatment of the majority of solid tumors. However, cisplatin induces a dose-dependent toxic damage to the kidneys [5,7,8,10].
authors.affiliation: N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
authors.forename: N V
authors.initials: NV
authors.lastname: Lyubimova
authors.forename: S V
authors.initials: SV
authors.lastname: Topchieva
authors.forename: S G
authors.initials: SG
authors.lastname: Averinova
authors.forename: A V
authors.initials: AV
authors.lastname: Kashkadaeva
authors.forename: V A
authors.initials: VA
authors.lastname: Gorbunova
authors.forename: S V
authors.initials: SV
authors.lastname: Shiryaev
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskii
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology*; D007674:Kidney Diseases / Q000139:chemically induced / Q000175:diagnosis*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin