[Prevalence of anti-CMV antibodies in blood donors in the Sfax region (value in blood transfusion)].
Detection of anti-CMV antibodies was carried out in sera of healthy blood donors, divided into groups of 20 according to age and sex. Sera were tested for anti-CMV by an ELISA test (Enzygnost anti-CMV/IgG-Behring). Among 280 sera, 272 were positive for IgG to CMV (97.14%). The prevalence of those antibodies was high in all age stratum (95-100%) but was higher in women than in men (98.57% versus 95.71%). The titre of IgG to CMV was superior to 12 Ul/ml in 56.43% of CMV positive donors. So, the leucocyte removal is the only alternative for the prevention of post-transfusional CMV infection. The high percentage of donors with anti-CMV antibodies level more than to 12 Ul/ml allow to consider the use of plasmapheresis for preparing specific immunoglobulins to CMV.
Gargouri
J
J
Centre Régional de Transfusion Sanguine de Sfax.
Elleuch
H
H
Karray
H
H
Rekik
H
H
Hammami
A
A
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000914:Antibodies, Viral / Q000097:blood*; D001782:Blood Donors / Q000706:statistics & numerical data*; D001803:Blood Transfusion / Q000379:methods; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control / Q000635:transmission; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007937:Leukapheresis; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D065227:Transfusion Reaction; D014416:Tunisia / Q000453:epidemiology
D000914:Antibodies, Viral; D007074:Immunoglobulin G