title: Validation of markers for their relevance to health and disease.
abstract: Validation of markers requires two different steps. The first one is the analytical validation including analytical procedures, definition of standard reference, and round-tests analysis. The second one is the assessment of the biological relevance of the selected marker. This biological relevance may be in the field of physiology to measure a physiological function, or in the area of pathology to measure a disease. Validation of markers is a time-consuming task that needs cooperation between laboratories. On the other hand a validated marker is a keystone for scientists to share their results and to explore more efficiently a given biological system.
authors.affiliation: Groupe Danone, Le Plessis-Robinson, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Antoine
authors.forename: A T
authors.initials: AT
authors.lastname: Diplock
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000175:diagnosis; D002386:Cataract / Q000175:diagnosis; D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis; D012015:Reference Standards; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers