title: Effects of metal ions on simultaneous production of glucose oxidase and catalase by Aspergillus niger.
abstract: The effects of various metal ions on the simultaneous production of glucose oxidase and catalase by Aspergillus niger were investigated. Calcium carbonate induced synthesis of both enzymes. The induction of calcium carbonate was accompanied by a metabolic shift from the glycolytic pathway (EMP, Embden-Meyerhof-Parnas) to direct oxidation of glucose by glucose oxidase. The time course of the biosynthesis of both enzymes is reported. The logistic model was in good agreement with the experimental growth results. The production of both enzymes was growth-associated. Finally, a model of growth and product formation was also proposed.
authors.affiliation: The Key Laboratory of Gene Engineering of Ministry of Education and Department of Chemistry, Zhongshan University, Guangzhou, China.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Liu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Huang
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: L P
authors.initials: LP
authors.lastname: Weng
authors.forename: L N
authors.initials: LN
authors.lastname: Ji
mesh_terms: D001234:Aspergillus niger / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D002119:Calcium Carbonate / Q000494:pharmacology; D002374:Catalase / Q000096:biosynthesis*; D004790:Enzyme Induction; D005947:Glucose / Q000378:metabolism; D005949:Glucose Oxidase / Q000096:biosynthesis*; D008670:Metals / Q000494:pharmacology*
chemical_list: D008670:Metals; D005949:Glucose Oxidase; D002374:Catalase; D002119:Calcium Carbonate; D005947:Glucose