[IL-8 in experimental proliferative vitreoretiopathy induced by macrophages].
OBJECTIVE
To measure the concentration changes of IL-8 during the development of experimental proliferative vitreoretiopathy (PVR) induecd by macrophages and explore the effect on the inflammatory cells at the early stage of the model.


METHODS
Rabbit PVR model was induced by homogenous macrophages. The vitreous, agueous and vein blood were taken at different periods and IL-8 levels in them were measured with an ELISA kit.


RESULTS
The IL-8 level reached its peak of 1,325 pg/ml at 14th day in the model which was 14 times as the level of controls. The level then decreased to 48 pg/ml at 28th day after macrophage injection.


CONCLUSIONS
The changes of IL-8 in the model were parallel to the inflammatory reaction during the development of PVR, suggesting that IL-8 may play an important role the inflammatory cells' infiltrating and migrating to the vitreous.
Shi
Y
Y
Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, China.
Hui
Y
Y
Zhang
X
X
Yang
K
K
Yu
C
C
D000818:Animals; D016209:Interleukin-8 / Q000378:metabolism*; D008264:Macrophages; D011817:Rabbits; D013997:Time Factors; D018630:Vitreoretinopathy, Proliferative / Q000209:etiology / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism
D016209:Interleukin-8