title: Chromosomal changes in a dedifferentiated chondrosarcoma: a case report and review of the literature.
abstract: The chromosome abnormalities observed in a dedifferentiated chondrosarcoma are reported. A new molecular cytogenetic technique, spectral karyotyping, was used to identify and confirm structural rearrangements in this case. A review of the literature revealed that nine cases have been reported, in eight of which a complete description of the cytogenetic abnormalities was described. Structural aberrations were most frequently reported in chromosomes 1 and 9, and chromosomes 7 and 19 were most frequently observed to be involved in numerical aberrations (trisomy and tetrasomy). In chondrosarcomas, structural aberrations in chromosomes 1 and 9 and trisomy or tetrasomy of chromosome 7 are among the more frequently observed aberrations.
authors.affiliation: Department of Pathology, Loma Linda University Medical Center, Loma Linda, CA, USA.
authors.forename: D P
authors.initials: DP
authors.lastname: O'Malley
authors.forename: K E
authors.initials: KE
authors.lastname: Opheim
authors.forename: T S
authors.initials: TS
authors.lastname: Barry
authors.forename: D B
authors.initials: DB
authors.lastname: Chapman
authors.forename: M J
authors.initials: MJ
authors.lastname: Emond
authors.forename: E U
authors.initials: EU
authors.lastname: Conrad
authors.forename: T H
authors.initials: TH
authors.lastname: Norwood
mesh_terms: D019645:Arthroplasty, Replacement, Knee; D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002869:Chromosome Aberrations; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005266:Femoral Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged