title: [The determinations of tumor necrosis factor and interleukin 6 in serum of patients with sudden sensorineural hearing loss].
abstract: Serum level of tumor necrosis factor(TNF alpha) and interleukin 6(IL-6) were determined in 32 patients with sudden sensorineural hearing loss (SSHL), 15 patients with progressive sensorineural hearing loss(PSHL) and 20 normal controls by using enzyme-linked immunosorbent assay. The results showed that plasma TNF alpha and IL-6 levels in patients with SSHL were higher than those in PSHL group and in normal control group (P < 0.05). The study suggested that the TNF alpha and IL-6 played an important role in the pathogenesis of SSHL.
authors.affiliation: Department of Otolaryngology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000097:blood*; D003639:Hearing Loss, Sudden / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha