title: Quantification of the diastolic notch in Doppler ultrasound screening of uterine arteries.
abstract: OBJECTIVE
  To investigate a new method of quantification of the diastolic notch of the flow velocity waveforms of uterine arteries in the prediction of hypertensive disorders of pregnancy.
  
  
  METHODS
  Pulsed-wave Doppler was used to obtain flow velocity waveforms (FVWs) from the uterine arteries at 21-22 weeks of gestation from 531 nulliparous women and 94 multiparous women at high risk. From the FVWs, both the pulsatility index (PI) and the notch index (NI) were calculated and the predictive values for both indices were compared using logistic regression analysis for mild and severe early onset hypertensive pregnancy complications.
  
  
  RESULTS
  Both the PI and the NI were poor predictors for mild gestational hypertension and pre-eclampsia; predictive values for severe early onset disease, however, were much better. Logistic regression analysis showed the NI has no additional value compared with the PI in the prediction of either mild or severe disease.
  
  
  CONCLUSIONS
  The NI offers the possibility to quantify the diastolic notch in uterine artery analysis. Compared to the PI, this does not lead to better predictive values for hypertensive disorders of pregnancy.
authors.affiliation: Department of Obstetrics and Gynaecology, Division of Obstetrics and Perinatal Medicine, University Hospital, Post-box 30.001, 9700RB Groningen, The Netherlands.
authors.forename: M W
authors.initials: MW
authors.lastname: Aardema
authors.forename: B T
authors.initials: BT
authors.lastname: De Wolf
authors.forename: M C
authors.initials: MC
authors.lastname: Saro
authors.forename: H
authors.initials: H
authors.lastname: Oosterhof
authors.forename: V
authors.initials: V
authors.lastname: Fidler
authors.forename: J G
authors.initials: JG
authors.lastname: Aarnoudse
mesh_terms: D001158:Arteries / Q000000981:diagnostic imaging; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging*; D010298:Parity; D021041:Placental Circulation; D011225:Pre-Eclampsia / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000000981:diagnostic imaging*; D018566:Pregnancy, High-Risk; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color; D016216:Ultrasonography, Prenatal; D014599:Uterus / Q000098:blood supply*