Peroxisome biogenesis and degradation in yeast: a structure/function analysis.
In yeast, peroxisomes are the site of specific catabolic pathways that characteristically include hydrogen peroxide producing oxidases and catalase. During the last 10 years, much progress has been made in unravelling the molecular mechanisms involved in the biogenesis of this organelle. At present, 23 different genes (PEX genes) have been identified that are involved in different aspects of peroxisome biogenesis (e.g., proliferation, formation of the peroxisomal membrane, import of matrix proteins). The principles of peroxisome degradation are still much less understood. Recently, the first yeast mutants affected in this process have become available and used to clone corresponding genes by functional complementation. In this paper, an overview is presented of the research on yeast peroxisomes, focusing on recent achievements in the molecular aspects of peroxisome development, function, and turnover.
Veenhuis
M
M
Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands. M.Veenhuis@biol.rug.nl
Salomons
F A
FA
Van Der Klei
I J
IJ
D053402:PHEX Phosphate Regulating Neutral Endopeptidase; D020675:Peroxisomes / Q000502:physiology* / Q000648:ultrastructure*; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D015003:Yeasts / Q000502:physiology* / Q000648:ultrastructure
D011506:Proteins; D053402:PHEX Phosphate Regulating Neutral Endopeptidase