title: Palladium-catalyzed intramolecular delta-lactam formation of aryl halides and amide-enolates: syntheses of cherylline and latifine.
abstract: [reaction: see text] Palladium-catalyzed intramolecular carbon-carbon bond formation of aryl halides and amide-enolates gave 4-arylisoquinoline derivatives in good yields, which were further converted into the isoquinoline alkaloids cherylline and latifine.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan. honda@hoshi.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Honda
authors.forename: H
authors.initials: H
authors.lastname: Namiki
authors.forename: F
authors.initials: F
authors.lastname: Satoh
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D047151:Amaryllidaceae Alkaloids; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D007769:Lactams / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D006846:Hydrocarbons, Halogenated; D007546:Isoquinolines; D007769:Lactams; C424145:cherylline; C424146:latifine; D010165:Palladium