The use of 2 health-related quality-of-life measures in a sample of persons infected with human immunodeficiency virus.
The purpose of this analysis was to examine the ability of the MOS-HIV (Medical Outcomes Study-Human Immunodeficiency Virus) Health Survey and the EuroQol Group's EQ-5D questionnaire to discriminate between subjects in predefined disease-severity groups on the basis of clinical-indicator status (i.e., CD4 cell counts, HIV type 1 [HIV-1] RNA copies). This study used medical records of and instruments completed by 242 HIV-infected patients. The ability of the health-related quality-of-life instruments to discriminate between subjects stratified by disease severity was assessed by means of receiver-operating characteristic (ROC) curve analysis. The EQ-5D (P<.05) and MOS-HIV physical health summary (PHS) scores (P<.01) were able to discriminate between groups of subjects stratified by disease severity on the basis of either CD4 cell counts or HIV-1 RNA copies. These findings provide further evidence of the validity of the use of EQ-5D and the MOS-HIV questionnaire and suggest that they may be practical tools for the monitoring of health status from the HIV-infected patient's perspective.
Delate
T
T
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona Health Sciences Center, Tucson, AZ, USA. delate@pharmacy.arizona.edu
Coons
S J
SJ
D000328:Adult; D000368:Aged; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology* / Q000523:psychology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012367:RNA, Viral / Q000032:analysis; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D019562:Viral Load
D012367:RNA, Viral