[New findings on the pathogenesis of psoriasis].
Psoriasis is currently considered to be an inflammatory disease of the skin mediated by T-lymphocytes. The key role in the pathogenesis of psoriasis is played by IL-8 which together with INF-gamma have a mitogenic effect on keratinocytes and trigger their hyperproliferation and activation of neutrofile leucocytes as well as the inflammatory reaction. The skin afflicted with psoriatic lesions contains 100-times increased expression of active IL-8. Its most significant source is probably represented by keratinocytes, but it is produced also by endothelial cells, fibroblasts, T-lymphocytes, polymorphonuclear leucocytes, fibroblasts, Langerhans cells, macrophages. The revealed pathogenetic coincidences render new prospective possibilities in the treatment of psoriasis.
Svecova
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Dermatovenerologická klinika LFUK v Bratislave. svecova@fmed.uniba.sk
D006801:Humans; D016209:Interleukin-8 / Q000502:physiology; D015603:Keratinocytes / Q000502:physiology; D011565:Psoriasis / Q000276:immunology / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000276:immunology
D016209:Interleukin-8