title: Increased survival after cecal ligation and puncture in mice consuming diets enriched with sesame seed oil.
abstract: OBJECTIVE
  Lignans that present in the nonfat portion of sesame seed oil (SSO) can inhibit delta-5 desaturase activity, resulting in an increase in the accumulation of dihomo-gamma-linolenic acid and, subsequently, decrease the production of proinflammatory dienoic eicosanoids with a concomitant increase in the secretion of less inflammatory monoenoic eicosanoids.
  
  
  METHODS
  Female Balb/c mice were fed diets supplemented with 5wt% SSO or a physical mixture of oils (control) whose fatty acid composition resembled that of SSO for 3 wks.
  
  
  RESULTS
  During a 4-day observation period after cecal ligation and puncture, only 20% of the controls and as many as 65% in the SSO group survived. Furthermore, the levels of cytokines and dienoic eicosanoids produced in response to an intraperitoneal injection of a nonlethal dose (50 microg/mouse) of endotoxin were measured in both groups. The interleukin (IL)-10 levels were markedly higher in mice fed SSO diets compared with the controls. However, the plasma concentrations of prostaglandin E1 + 2, tumor necrosis factor-alpha, IL-6, and IL-12 did not differ significantly between the two groups of mice.
  
  
  CONCLUSIONS
  Because the fatty acid composition is almost similar between the two diets, sesamin, sesamol and other lignans in SSO appear to be responsible for an increase in survival after cecal ligation and puncture and also for an increase in the IL-10 levels in response to a nonlethal dose of endotoxin in mice.
authors.affiliation: Department of Surgery, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Chavali
authors.forename: T
authors.initials: T
authors.lastname: Utsunomiya
authors.forename: R A
authors.initials: RA
authors.lastname: Forse
mesh_terms: D000818:Animals; D002432:Cecum / Q000293:injuries; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D019587:Dietary Supplements; D015232:Dinoprostone / Q000097:blood; D005260:Female; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D017705:Lignans / Q000276:immunology; D008070:Lipopolysaccharides; D051379:Mice; D008807:Mice, Inbred BALB C; D012715:Sesame Oil; D012772:Shock, Septic / Q000276:immunology* / Q000401:mortality*; D018709:Statistics, Nonparametric; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014950:Wounds, Penetrating / Q000150:complications
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D017705:Lignans; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D012715:Sesame Oil; D015232:Dinoprostone