Systemic antineutrophil cytoplasmic antibody vasculitis associated with lymphoid neoplasia.
Two cases of systemic antineutrophil cytoplasmic antibody (ANCA) vasculitis in the setting of chronic lymphocytic leukaemia and angioimmunoblastic lymphadenopathy type T cell lymphoma are reported. The two patients had fever of unknown origin associated with cutaneous vasculitis and "pulmonary-renal syndrome" with alveolar haemorrhage. Despite anti-infectious treatments, steroids, and chemotherapy, the vasculitis had a fatal paraneoplastic course in several weeks. When infection is excluded in patients with malignancy, atypical features should be promptly investigated for systemic vasculitis, and an ANCA test performed.
Hamidou
M A
MA
Department of Internal Medicine, University Hospital, Hôtel-Dieu, Nantes 44035, France. mohamed.hamidou@chu-nantes.fr
El Kouri
D
D
Audrain
M
M
Grolleau
J Y
JY
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D017809:Fatal Outcome; D005335:Fever of Unknown Origin / Q000209:etiology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014657:Vasculitis / Q000209:etiology* / Q000276:immunology
D019268:Antibodies, Antineutrophil Cytoplasmic