[Post-ischemic myocardial protection with Cabernet-Sauvignon red wine].
The objective was to assess the action of two Argentine (from Mendoza) non-alcoholic red wine extracts (Cabernet-Sauvignon (CS) and a generic control (G)) on myocardial stunning that follows the reperfusion period. In the isolated isovolumically perfused rat heart the recovery of systolic and diastolic functions after 20 min of global ischemia were assessed through left ventricular developed pressure (LVDP) and end diastolic pressure (EDP), respectively. After 30 min of reperfusion LVDP recovered to 66 +/- 7% in control ischemic hearts. The administration of non-alcoholic extract of CS not of G wine significantly increased the post-ischemic recovery (101 +/- 4%, p < 0.05) of the hearts. The ischemic contracture was not modified by either of the wines. However, during reperfusion the CS, not the G wine, decreased significantly the increase in EDP observed in control ischemic hearts. These results present experimental evidence that the non-alcoholic extracts of CS and not of G Argentine red wine induces protection of postischemic myocardial function.
Mosca
S M
SM
Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina. smosca@attas.med.unlp.edu.ar
Cingolani
H E
HE
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D006321:Heart / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects*; D015425:Myocardial Reperfusion; D017682:Myocardial Stunning / Q000503:physiopathology / Q000628:therapy*; D051381:Rats; D014920:Wine
D000975:Antioxidants