Dyshaemopoietic bone marrow features in healthy subjects are related to age.
We have quantified bone marrow dyshaemopoietic features in 54 "healthy" people aged 18-85 without peripheral blood cytopenia and we have detected a statistically significant positive correlation between age and both bone marrow dyserythropoietic and dysgranulopoietic features (r=+0.70, p<0.001 and r=+0.275, p=0.044, respectively), as well as a negative correlation between age and bone marrow blast cell count (r=-0.329, p=0.016). After taking into account other covariates, smokers showed in their bone marrow, at any age, a 3.73% higher percentage of dyserythropoietic features and a 0.28% higher percentage of blast cells than non-smokers.
Fernández-Ferrero
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Servicio de Hematología, Hospital de León, Altos de Nava s/n, E-24071 León, Spain.
Ramos
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F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology*; D001853:Bone Marrow / Q000502:physiology*; D005260:Female; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012907:Smoking