Gonadectomy unmasks an inhibitory effect of progesterone on amygdala kindling in male rats.
Previous studies have suggested that the effects of progesterone on kindling in rats may be sexually differentiated, significant effects of physiological levels of progesterone being observed only in females. The present study demonstrates that this difference results from the hormones secreted by the testes. Thus, in orchidectomized males, progesterone induces a delay in the onset of amygdala-kindled seizures similar to that observed in females.
Edwards
H E
HE
Department of Physiology, University of Toronto, Ontario, Toronto, Canada.
Mo
V
V
Burnham
W M
WM
MacLusky
N J
NJ
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009919:Orchiectomy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D011374:Progesterone