title: Bombesin-induced HPA and sympathetic activation requires CRH receptors.
abstract: Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons.
authors.affiliation: School of Psychology, University of Ottawa, 11 Marie Curie, Ottawa, Ontario, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Kent
authors.forename: T
authors.initials: T
authors.lastname: Bédard
authors.forename: S
authors.initials: S
authors.lastname: Khan
authors.forename: H
authors.initials: H
authors.lastname: Anisman
authors.forename: Z
authors.initials: Z
authors.lastname: Merali
mesh_terms: D000818:Animals; D001839:Bombesin / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018019:Receptors, Corticotropin-Releasing Hormone / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*
chemical_list: D018019:Receptors, Corticotropin-Releasing Hormone; D001839:Bombesin