title: Severe glomerular sclerosis is not associated with poor outcome after kidney transplantation.
abstract: BACKGROUND
  The increased utilization of expanded criteria kidney donors has necessitated the reevaluation of multiple donor risk factors to insure the best outcome from this valuable resource. Reports of decreased graft survival in recipients of kidneys from donors with > or =20% glomerular sclerosis (GS) have led many transplant centers to refuse these donor kidneys. The purpose of this study is to compare outcome in recipients of cadaveric donor kidneys with > or =20% GS versus those with <20% or no GS at our center.
  
  
  METHODS
  We retrospectively reviewed 18 donor and 19 recipient and outcome variables in 89 recipients of kidneys, which were biopsied at the time of transplantation, between February 1995 and November 1998. We evaluated outcome based upon the percent of GS and the degree of vasculopathy.
  
  
  RESULTS
  Donors with > or =20% GS were older and had more hypertension. Recipients of kidneys with > or =20% GS were older, had higher serum creatinine values at 1 and 2 years, but similar rates of delayed graft function and 2-year graft survival. Vasculopathy did not correlate to any important donor criteria except the percent GS. However, serum creatinine was significantly higher in recipients of kidneys with moderate vasculopathy versus none, up to 2 years after transplantation. There was no significant difference in graft loss based upon vasculopathy.
  
  
  CONCLUSIONS
  Kidneys from donors with > or =20% GS provide excellent outcome similar to kidneys from donors with no GS.
authors.affiliation: Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Lu
authors.forename: D
authors.initials: D
authors.lastname: Desai
authors.forename: B D
authors.initials: BD
authors.lastname: Myers
authors.forename: D C
authors.initials: DC
authors.lastname: Dafoe
authors.forename: E J
authors.initials: EJ
authors.lastname: Alfrey
mesh_terms: D000328:Adult; D000075202:Contraindications; D003404:Creatinine / Q000097:blood; D006085:Graft Survival; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery; D007678:Kidney Glomerulus / Q000473:pathology*; D016030:Kidney Transplantation; D008875:Middle Aged; D012189:Retrospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome
chemical_list: D003404:Creatinine