title: [A case of pulmonary fibrosis with many asbestos bodies in bronchoalveolar lavage fluid after exposure to asbestos and man-made mineral fibers].
abstract: We report a case of severe pulmonary fibrosis in a patient exposed to asbestos and other natural and man-made mineral fibers (MMMF) over a period of time. A 63-year-old man was admitted to our hospital because of progressive dyspnea and severe hypoxemia with hypercapnea. Mineral fibers recovered by bronchoalveolar lavage were analyzed by scanning electron microscope (SEM) and energy-dispersive x-ray spectroscopy (SEM-EDS). The bronchoalveolar lavage fluid (BALF) included a large number of asbestos bodies (116,000/ml). The cores of the asbestos fibers were crocidolite, and no vitreous fibers nor other kinds of man-made mineral fibers (MMMFs) were identified. To our knowledge, the number of asbestos bodies per ml of this patient's BALF is the greatest ever reported. Insufficient personal protection of the airways, high concentrations of inhaled fibers, co-exposure to cigarette smoke, and prolonged biopersistence of crocidolite asbestos fibers are presumed to be the causes of such severe asbestosis.
authors.affiliation: Department of Respiratory Disease, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yatera
authors.forename: C
authors.initials: C
authors.lastname: Yoshii
authors.forename: Y
authors.initials: Y
authors.lastname: Morimoto
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Imanaga
authors.forename: H
authors.initials: H
authors.lastname: Yamato
authors.forename: M
authors.initials: M
authors.lastname: Kido
mesh_terms: D001194:Asbestos / Q000009:adverse effects* / Q000032:analysis*; D001195:Asbestosis / Q000209:etiology* / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019016:Mineral Fibers / Q000009:adverse effects*; D016273:Occupational Exposure / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000378:metabolism
chemical_list: D019016:Mineral Fibers; D001194:Asbestos