title: Functional disturbances in hemopoietic microenvironment in various forms of myelodysplastic syndrome.
abstract: We studied the ability of stromal sublayer of long-term bone marrow cultures and peripheral blood macrophages from patients with various forms of myelodysplastic syndrome to maintain the growth of normal granulocyte-macrophage colony-forming units in mixed cultures. There were changes in the hemopoietic microenvironment in these patients: decreased cellularity of the bone marrow and impaired formation of sublayers in long-term bone marrow cultures, production of growth factors, maintaining the growth of normal granulocyte-macrophage precursors by stromal cells. Dysfunction of macrophages in the stromal microenvironment was probably related to the presence of pathological macrophages./Abstract>
authors.affiliation: Laboratory of Hemopoiesis Physiology, Hematology Research Center, Russian Academy of Medical Sciences, Moscow.
authors.forename: T
authors.initials: T
authors.lastname: Manakova
authors.forename: L
authors.initials: L
authors.lastname: Gerasimova
authors.forename: N
authors.initials: N
authors.lastname: Tsvetaeva
authors.forename: K
authors.initials: K
authors.lastname: Momotyuk
mesh_terms: D001853:Bone Marrow / Q000473:pathology / Q000503:physiopathology*; D006410:Hematopoiesis; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000473:pathology / Q000503:physiopathology*