Osteopenia assessed by body composition analysis is related to malnutrition in alcoholic patients.
Osteopenia is frequent among alcoholics. Its pathogenesis seems to be multifactorial, including ethanol intake, hormonal changes, liver cirrhosis, and malnutrition. Our objective is to determine the relative role of malnutrition on bone loss. One hundred and eighty-one male alcoholic patients, drinkers of more than 80 g ethanol/day, were included, recording data on the intensity of alcoholism, liver cirrhosis, nutritional assessment based on feeding habits, body mass index (BMI), midarm anthropometrics, subjective nutritional assessment, lean and fat mass by dual energy X-ray absorptiometry (DEXA), serum proteins and insulin growth factor Type I (IGF-I), calcitropic hormones, parathyroid hormone (PTH), osteocalcin 25OHD3, and bone mass assessed by DEXA, which was also performed in 43 healthy controls. Alcoholics showed decreased serum osteocalcin, PTH, 25OHD3, IGF-I, and bone mass. Alcoholics were frequently malnourished with decreased BMI, lean, and fat mass. The loss of bone mass was not related to the alteration of calcitropic hormones, to the intensity of alcoholism, or to the existence of liver cirrhosis, but to malnutrition. For a similar BMI, bone loss was more intense in alcoholics than in controls, especially in those with irregular feeding habits. Although cross-sectional ones, our data suggest that alcoholic osteopenia may be interpreted as a form of nutritional osteoporosis, notwithstanding the influence of other factors.
Santolaria
F
F
Servicio de Medicina Interna, Hospital Universitario de Canarias, Universidad de la Laguna, Tenerife, Spain.
González-Reimers
E
E
Pérez-Manzano
J L
JL
Milena
A
A
Gómez-Rodríguez
M A
MA
González-Díaz
A
A
de la Vega
M J
MJ
Martínez-Riera
A
A
D015502:Absorptiometry, Photon; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D001798:Blood Proteins / Q000032:analysis; D001823:Body Composition; D015992:Body Mass Index; D001851:Bone Diseases, Metabolic / Q000175:diagnosis* / Q000209:etiology*; D002112:Calcifediol / Q000097:blood; D002116:Calcitonin / Q000097:blood; D000431:Ethanol / Q000008:administration & dosage; D006519:Hepatitis, Alcoholic / Q000150:complications; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015596:Nutrition Assessment; D009748:Nutrition Disorders / Q000150:complications*; D009752:Nutritional Status; D015675:Osteocalcin / Q000097:blood; D019512:Pancreatitis, Alcoholic / Q000150:complications; D010281:Parathyroid Hormone / Q000097:blood
D001798:Blood Proteins; D010281:Parathyroid Hormone; D015675:Osteocalcin; D000431:Ethanol; D007334:Insulin-Like Growth Factor I; D002116:Calcitonin; D002112:Calcifediol