Development. Hear, hear, for the inner ear.
Although the development of the inner ear has been a favorite subject for biologists to study, it is not yet clear exactly which molecules are involved in the induction of the otic placode, the plug of embryonic ectoderm that will become the inner ear. In his Perspective, Graham takes us on an inner ear odyssey, explaining how the signaling molecules FGF-19 and Wnt-8c cooperate to induce formation of the otic placode (Ladher et al.).
Graham
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MRC Centre for Developmental Neurobiology, Kings College London, London SE1 1UL, UK. anthony.graham@kcl.ac.uk
D000818:Animals; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism; D002642:Chick Embryo; D018920:Coculture Techniques; D046508:Culture Techniques; D007758:Ear, Inner / Q000196:embryology* / Q000378:metabolism; D004475:Ectoderm / Q000378:metabolism; D004627:Embryonic Induction; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D008648:Mesoderm / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins; D029961:Zebrafish Proteins
C117476:FGF19 protein, human; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D005346:Fibroblast Growth Factors