Stability of cefotaxime sodium in solid state.
The influence of temperature and relative humidity on the stability of cefotaxime sodium in the solid state was investigated. Changes in the concentration of cefotaxime sodium were followed by a HPLC method with UV detection. The kinetic and thermodynamic parameters of the decomposition reaction were calculated.
Zajac
M
M
Department of Pharmaceutical Chemistry, University of Medical Sciences, Poznań, Poland.
Musiał
W
W
Pawłowski
L
L
D002439:Cefotaxime / Q000737:chemistry*; D002511:Cephalosporins / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006813:Humidity; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013816:Thermodynamics
D002511:Cephalosporins; D002439:Cefotaxime