[Effects of hypertonic solution on the membrane potential of isolated outer hair cell in the guinea pig cochlear].
To learn effects of hypertonic solution on the membrane potential and cell length of isolated outer hair cell in the guinea pig cochlear, we determined the membrane potential and cell length during hypertonic activation with ACAS 570 and the membrane potential sensitive probe DiBAC4(3). The results showed that the hypertonic activation depolarized the outer hair cell and made it elongate. We think that the outer hair cell has activity, the depolarization and elongation of the outer hair cell caused by hypertonic solution are cyto-electrophysiological basis of hearing loss and recruitment in Meniere's disease.
Jiang
J
J
Department of Otolaryngology, 305 Hospital of PLA, Beijing 100017.
Huang
Y
Y
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000502:physiology*; D006982:Hypertonic Solutions / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects
D006982:Hypertonic Solutions