Asymmetric cell division: fly neuroblast meets worm zygote.
Both Drosophila neuroblasts and Caenorhabditis elegans zygotes use a conserved protein complex to establish cell polarity and regulate spindle orientation. Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote.
Doe
C Q
CQ
Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, Oregon 97403, USA.
Bowerman
B
B
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology*; D002455:Cell Division / Q000502:physiology; D016764:Cell Polarity / Q000502:physiology; D004330:Drosophila / Q000166:cytology / Q000196:embryology*; D006801:Humans; D009420:Nervous System / Q000166:cytology / Q000196:embryology*; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D015053:Zygote / Q000166:cytology* / Q000254:growth & development