Successful chelation therapy in a case of neonatal iron overload following intravascular intrauterine transfusion.
OBJECTIVE
We report a newborn infant who was successfully treated with chelation therapy having developed severe liver disease secondary to iron overload following multiple intrauterine, intravascular transfusions (IVTs).


METHODS
Case report with review of the literature.


RESULTS
An infant was born at 33 weeks' gestation having received multiple IVTs for severe rhesus hemolytic disease. At birth there was severe anemia with hydrops and ascites. Severe liver disease was present with portal hypertension, coagulopathy and abnormal liver enzymes. A liver biopsy showed histologic features consistent with iron overload. The serum ferritin was in excess of 4000 micrograms/l. A 7-week course of deferoxamine resulted in a marked reduction in ferritin levels and significant improvement in liver function.


CONCLUSIONS
The possibility of neonatal iron overload following multiple IVTs should be borne in mind. Successful chelation therapy is possible in such cases.
Sreenan
C
C
Neonatal Intensive Care Unit, University of Alberta Hospital, Canada.
Idikio
H A
HA
Osiovich
H
H
D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects*; D015913:Chelation Therapy; D004899:Erythroblastosis, Fetal / Q000628:therapy; D005260:Female; D005315:Fetal Diseases / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D019190:Iron Overload / Q000209:etiology* / Q000473:pathology / Q000628:therapy*; D008099:Liver / Q000473:pathology; D011247:Pregnancy