Emotional state and one-trial learning in OXYS rats with hereditarily elevated production of oxygen radicals.
Comparative analysis of unconditioned and conditioned behavior of Wistar and prematurely aging OXYS rats revealed that the latter have significantly reduced locomotor and exploratory activities, increased anxiety in the elevated plus-maze test, spatial disorientation, and abnormal associative learning. OXYS rats can be used as a biological model for studying molecular, neurobiological, and neurochemical mechanisms of brain aging.
Loskutova
L V
LV
Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Kolosova
N G
NG
D019588:Aging, Premature / Q000235:genetics / Q000378:metabolism* / Q000523:psychology*; D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004195:Disease Models, Animal; D004644:Emotions / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D009043:Motor Activity / Q000235:genetics / Q000502:physiology; D009154:Mutation; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species