title: The conditional nature of the dietary need for polyunsaturates: a proposal to reclassify 'essential fatty acids' as 'conditionally-indispensable' or 'conditionally-dispensable' fatty acids.
abstract: The term essential fatty acid no longer clearly identifies the fatty acids it was originally used to describe. It would be more informative if the concept of essentiality shifted away from the symptoms arising from the lack of de novo synthesis of linoleate or alpha-linolenate and towards the adequacy of the capacity for synthesis and conservation of both the parent and the derived long-chain polyunsaturates. For instance, despite the existence of the pathway for synthesis of docosahexaenoate from alpha-linolenate, the former would be more correctly classified as 'conditionally indispensable' because the capacity of the pathway appears insufficient during early development, although it may be sufficient later in life in healthy individuals. Similarly, despite the inability to synthesize linoleate de novo, abundant linoleate stores and its relatively slow turnover in healthy adults probably makes linoleate 'conditionally dispensable' for long periods. There are two other anomalies with the terms essential and non-essential fatty acids: (1) under several different experimental circumstances, the C-skeleton of essential fatty acids is avidly used in the synthesis of non-essential fatty acids; (2) to function normally, the brain is required to endogenously synthesize several non-essential fatty acids. As with essential amino acids, which have been reclassified as indispensable or conditionally indispensable, such a change in terminology should lead to an improved understanding of the function and metabolism of polyunsaturates in particular, and long-chain fatty acids in general.
authors.affiliation: Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada. cunnane@utoronto.ca.
authors.forename: S C
authors.initials: SC
authors.lastname: Cunnane
mesh_terms: D005228:Fatty Acids, Essential / Q000145:classification*; D006801:Humans; D019787:Linoleic Acid / Q000172:deficiency / Q000378:metabolism; D009751:Nutritional Requirements; D010084:Oxidation-Reduction; D009626:Terminology as Topic
chemical_list: D005228:Fatty Acids, Essential; D019787:Linoleic Acid