Stevens-Johnson syndrome caused by the antiretroviral drug nevirapine.
Nevirapine is a non-nucleoside reverse transcriptase inhibitor widely used in combination with other antiretroviral agents for the treatment of HIV infection. Severe rash, including the Stevens-Johnson syndrome (SJS), is the major toxicity of nevirapine and is described in the package labeling with a prominent, boxed warning. Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature. We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.
Metry
D W
DW
Department of Dermatology, The University of Texas Medical School at Houston, 77030, USA.
Lahart
C J
CJ
Farmer
K L
KL
Hebert
A A
AA
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019829:Nevirapine / Q000009:adverse effects* / Q000627:therapeutic use; D011379:Prognosis; D018570:Risk Assessment; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
D019380:Anti-HIV Agents; D019829:Nevirapine