title: Hepatitis C virus load is associated with human immunodeficiency virus type 1 disease progression in hemophiliacs.
abstract: Hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) coinfection is common in hemophiliacs and injection drug users. To assess the interaction between HCV load and HIV-1 disease progression, we examined 207 HIV-1/HCV-coinfected patients. Patients were followed prospectively for approximately 7 years, and annual measurements of CD4(+) cell counts and HCV and HIV-1 loads were obtained. Survival analysis was used to define the independent effects of HCV load on HIV-1 progression. After controlling for CD4(+) cell count and HIV-1 RNA level, every 10-fold increase in baseline HCV RNA was associated with a relative risk (RR) for clinical progression to acquired immunodeficiency syndrome (AIDS) of 1.66 (95% confidence interval [CI], 1.10-2.51; P=.016) and an RR for AIDS-related mortality of 1.54 (95% CI, 1.03-2.30; P=.036). These findings emphasize the need for further research regarding the use of HIV-1- and HCV-specific therapy in coinfected individuals.
authors.affiliation: Cedars-Sinai Burns and Allen Research Institute, Division of Infectious Diseases, B217, Department of Medicine, and University of California Los Angeles School of Medicine, 8700 Beverly Blvd., Los Angeles, CA 90048, USA. Daar@CSHS.org
authors.forename: E S
authors.initials: ES
authors.lastname: Daar
authors.forename: H
authors.initials: H
authors.lastname: Lynn
authors.forename: S
authors.initials: S
authors.lastname: Donfield
authors.forename: E
authors.initials: E
authors.lastname: Gomperts
authors.forename: S J
authors.initials: SJ
authors.lastname: O'Brien
authors.forename: M W
authors.initials: MW
authors.lastname: Hilgartner
authors.forename: W K
authors.initials: WK
authors.lastname: Hoots
authors.forename: D
authors.initials: D
authors.lastname: Chernoff
authors.forename: S
authors.initials: S
authors.lastname: Arkin
authors.forename: W Y
authors.initials: WY
authors.lastname: Wong
authors.forename: C A
authors.initials: CA
authors.lastname: Winkler
mesh_terms: D000293:Adolescent; D000328:Adult; D018791:CD4 Lymphocyte Count; D002648:Child; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications* / Q000401:mortality / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D006467:Hemophilia A / Q000821:virology*; D016174:Hepacivirus / Q000502:physiology*; D006526:Hepatitis C / Q000150:complications* / Q000821:virology; D006801:Humans; D011446:Prospective Studies; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load
chemical_list: D012367:RNA, Viral