[Chlorinated hydrocarbon insecticides(DDT, methoxychlor, HCH etc.)].
Endocrine disrupting properties of organochlorine(chlorinated hydrocarbon) insecticides are reviewed. Physicochemical properties such as water solubility and partition coefficient of the organochlorine insecticides greatly influence their environmental fates. Insolubility in water and high partition coefficient usually enhance the environmental persistence of the compounds. On the endocrine disrupting properties, an important metabolite of p,p'-DDT, p,p'-DDE, is known to exhibit weak anti-androgenic properties. An isomer o,p'-DDT is estrogenic. Metabolites of methoxychlor, mono-demethylated and di-demethylated methoxychlor derivatives, are weakly estrogenic. Their dehydochlorinated product also exhibits estrogenicity. HCH isomers are environmentally persistent compounds, but there is few reports on their endocrine disrupting properties. Some other organochlorine pesticides such as cyclodienes and chlordecone is reported to be estrogenic.
Kurihara
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D000726:Androgen Antagonists; D000818:Animals; D001673:Biodegradation, Environmental; D003634:DDT / Q000009:adverse effects / Q000378:metabolism; D004703:Endocrine System / Q000187:drug effects*; D004785:Environmental Pollutants / Q000009:adverse effects / Q000378:metabolism; D004968:Estrogens, Non-Steroidal; D001556:Hexachlorocyclohexane / Q000009:adverse effects / Q000378:metabolism; D006801:Humans; D007306:Insecticides / Q000009:adverse effects / Q000378:metabolism; D008731:Methoxychlor / Q000009:adverse effects / Q000378:metabolism
D000726:Androgen Antagonists; D004785:Environmental Pollutants; D004968:Estrogens, Non-Steroidal; D007306:Insecticides; D001556:Hexachlorocyclohexane; D003634:DDT; D008731:Methoxychlor