Efficacy of ofloxacin and other otic preparations for otitis externa.
Ofloxacin otic is as effective in curing otitis externa in children (<12 years of age) as is the preparation combining polymyxin/neomycin plus hydrocortisone and as ciprofloxacin otic. Furthermore ofloxacin otic, as it requires less frequent dosing, is likely to encourage greater patient adherence and consequently to achieve a better cure rate than both of these treatment options. Because a number of cases of otitis externa are complicated by an undiagnosed tympanic membrane perforation, the lack of ototoxicity associated with ofloxacin otic makes it a particularly safe option for use in these patients.
Ruben
R J
RJ
Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467-2401, USA. r.j.ruben@worldnet.att.net
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008876:Middle Ear Ventilation; D015242:Ofloxacin / Q000627:therapeutic use*; D010032:Otitis Externa / Q000188:drug therapy* / Q000382:microbiology; D012449:Safety; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D015242:Ofloxacin