title: Real-time molecular and cellular analysis: the new frontier of drug discovery.
abstract: The pharmaceutical industry is currently facing the challenge of maintaining increased efficiency and productivity while contending with a deluge of genomic and high-throughput screening data. To ease the bottlenecks at target validation and lead optimization, the industry must look to the living cell, the ultimate target of all drugs, as a source of new biological knowledge. This new 'cell-centric' perspective must integrate reagents that report on the state of molecular processes within the cell, automated detection and analysis of these processes, and cellular knowledge, building into a single platform.
authors.affiliation: Cellomics, Inc., 635 William Pitt Way, Pittsburgh, PA 15238, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Taylor
authors.forename: E S
authors.initials: ES
authors.lastname: Woo
authors.forename: K A
authors.initials: KA
authors.lastname: Giuliano
mesh_terms: D002477:Cells / Q000187:drug effects; D003199:Computer Systems; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000639:trends; D008164:Luminescent Proteins; D008853:Microscopy / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
chemical_list: D008164:Luminescent Proteins