Alteration in CD29(high) CD4(+) lymphocyte subset is a common feature of early HIV disease and of active tuberculosis.
Peripheral CD4 T-cell depletion has been observed in human immunodeficiency virus (HIV)-negative patients with pulmonary tuberculosis (TB). To investigate more accurately this alteration, we studied peripheral blood CD45RA(+) and CD29(high) CD4 subsets in 79 TB patients with (HIV(+)TB(+)) or without (HIV(-)TB(+)) HIV infection, 85 HIV-infected patients without TB (HIV(+)TB(-)), and 43 healthy controls, all living in West Africa. The high proportion of CD4(+)CD29(high) T cells observed in controls was dramatically decreased in CDC-A stage HIV(+)TB(-) patients. CD45RA(+) CD4(+) T cells were depleted during the CDC-B stage. Both the percentage and the absolute count of CD29(high)CD4(+) T cells were decreased in HIV(-)TB(+) and HIV(+)TB(+) patients versus controls, but CD45RA(+)CD4(+) T cells were not decreased in TB patients without HIV-infection. Although distinct alterations in the CD4(+) T-cell homeostasis are involved in TB(-) versus HIV-infected subjects, our data suggest that the CD29(+)CD4(+) T-cell depletion observed during the early HIV disease contributes to the risk of active TB, by reducing the pool of T cells able to relocalize to the sites of the M. tuberculosis multiplication.
Diagbouga
S
S
Centre Muraz, Organisation de Coordination et de Coopération pour la lutte contre les Grandes Endémies, Burkina Faso, West Africa. diagbouga_serge@hotmail.com
Chiron
J P
JP
Sanou
O
O
Ledru
E
E
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D000328:Adult; D002050:Burkina Faso / Q000453:epidemiology; D015704:CD4 Antigens / Q000032:analysis; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000145:classification*; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D019012:Integrin beta1 / Q000032:analysis*; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D016176:T-Lymphocyte Subsets; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000276:immunology*
D015704:CD4 Antigens; D019012:Integrin beta1; D017493:Leukocyte Common Antigens