title: Immunolocalisation of cartilage-derived retinoic acid-sensitive protein in pleomorphic adenoma of the parotid salivary gland.
abstract: Pleomorphic adenoma of the parotid salivary glands often contains chondroid elements and may exhibit cartilaginous and osseous differentiation, although the latter is extremely rare. Twenty-nine pleomorphic adenomas (PAs) of the parotid gland were examined immunohistochemically for the distribution of cartilage-derived retinoic acid-sensitive protein (CD-RAP), a recently described marker of chondrocytes, which may be important in the morphogenesis and development of the salivary gland. In the normal parotid gland, the ductal cells expressed CD-RAP, but not the myoepithelial cells. In the pleomorphic salivary adenomas, the duct-like cells, but not the myoepithelial cells, expressed CD-RAP. Since many authorities consider myoepithelial cells to be the source of the chondroid matrix, it is surprising that these cells do not express the chondrocytic marker, CD-RAP. Putative neoplastic myoepithelium in the pleomorphic adenoma and some cells in the myxochondroid areas expressed S-100 and calponin.
authors.affiliation: University Dental Hospital of Manchester, UK.
authors.forename: H
authors.initials: H
authors.lastname: Devlin
authors.forename: P
authors.initials: P
authors.lastname: Sloan
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000911:Antibodies, Monoclonal; D015415:Biomarkers / Q000032:analysis; D002135:Calcium-Binding Proteins / Q000032:analysis; D002356:Cartilage / Q000473:pathology*; D002454:Cell Differentiation; D019902:Chondrocytes / Q000473:pathology; D004396:Coloring Agents; D004847:Epithelial Cells / Q000473:pathology; D016326:Extracellular Matrix Proteins; D006801:Humans; D007150:Immunohistochemistry; D008840:Microfilament Proteins / Q000032:analysis; D009024:Morphogenesis; D009124:Muscle Proteins / Q000032:analysis; D009130:Muscle, Smooth / Q000473:pathology; D009363:Neoplasm Proteins; D010306:Parotid Gland / Q000473:pathology; D010307:Parotid Neoplasms / Q000473:pathology*; D011506:Proteins / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis; D018987:Salivary Ducts / Q000473:pathology; D000096985:Calponins
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004396:Coloring Agents; D016326:Extracellular Matrix Proteins; D008840:Microfilament Proteins; D009124:Muscle Proteins; D009363:Neoplasm Proteins; D011506:Proteins; D009418:S100 Proteins; D000096985:Calponins; C090059:MIA protein, human