Effect of regular intake of vitamin-mineral complex on spontaneous and on induced clustogenesis in humans.
Regular intake of a vitamin-mineral complex for 2 weeks had no effect on spontaneous clustogenesis in blood cells from healthy donors. Significant differences between the levels of chromosome aberrations induced by bleomycin and dioxidine in vitro before and after 2-week vitamin treatment indicate increased resistance of blood cells to clustogens.
Nikitina
V A
VA
Laboratory of Pharmacology of Mutagenesis, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Vrzhesinskaya
O A
OA
Beketova
N A
NA
Pereverzeva
O G
OG
Kharitonchik
L A
LA
Isaeva
V A
VA
Kodentsova
V M
VM
Spirichev
V B
VB
Durnev
A D
AD
D000328:Adult; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D001761:Bleomycin / Q000633:toxicity*; D002869:Chromosome Aberrations; D004336:Drug Antagonism; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000633:toxicity*; D011810:Quinoxalines / Q000633:toxicity*; D014815:Vitamins / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D009153:Mutagens; D011810:Quinoxalines; D014815:Vitamins; D001761:Bleomycin; C001077:dioxidine