Postoperative mortality in patients with liver cirrhosis undergoing transurethral resection of the prostate: a Danish nationwide cohort study.
OBJECTIVE
To examine the risk of 30-day postoperative mortality from transurethral resection of the prostate (TURP) in patients with liver cirrhosis, who are reportedly at considerably increased perioperative risk.


METHODS
For the period 1 January 1977 to 31 December 1993, a population-based cohort was identified comprising Danish patients diagnosed with liver cirrhosis and a random sample of Danes also undergoing TURP. Logistic regression models were used to estimate the association between liver cirrhosis, age, type of admission, comorbidity and 30-day mortality.


RESULTS
In a cohort of 23 133 patients with liver cirrhosis, 30 underwent TURP; 150 controls with no liver cirrhosis also underwent the same procedure. Of the patients with liver cirrhosis, 6.7% died within 30 days of TURP; the estimated adjusted odds ratio was 3.0 (95% confidence interval 0.4-22.9) for the 30-day postoperative mortality in patients with liver cirrhosis compared with patients without (mortality 2%). Advanced age, comorbidity and acute admission seemed to be associated with an increased postoperative mortality.


CONCLUSIONS
This study indicates that TURP in patients with liver cirrhosis was associated with increased mortality.
Nielsen
S S
SS
Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Aarhus, Denmark.
Thulstrup
A M
AM
Lund
L
L
Vilstrup
H
H
Sørensen
H T
HT
D000368:Aged; D015331:Cohort Studies; D016001:Confidence Intervals; D000075202:Contraindications; D003718:Denmark / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000401:mortality; D008297:Male; D016017:Odds Ratio; D011183:Postoperative Complications / Q000401:mortality*; D011470:Prostatic Hyperplasia / Q000150:complications / Q000601:surgery*; D012044:Regression Analysis; D012307:Risk Factors; D016019:Survival Analysis; D020728:Transurethral Resection of Prostate / Q000401:mortality; D016896:Treatment Outcome