Acute effects of transdermal estrogen in postmenopausal women with coronary artery disease. Using a clinically relevant estrogen dose and concurrent antianginal therapy.
In the present study the acute anti-ischemic effect of clinically relevant doses of transdermal estradiol during concurrent antianginal therapy was investigated in 14 postmenopausal women with stable coronary artery disease. Plasma estradiol was significantly increased, but no significant effects on time to angina, time to 1 mm S--T depression, total exercise time, maximum rate-pressure product, maximum S--T depression or maximum workload were found. However, resting diastolic blood pressure was significantly decreased due to estrogen.
Manhem
K
K
Clinical-Experimental Research Laboratory, Department of Medicine, Sahlgrenska University Hospital/Ostra, Göteborg University, Göteborg, Sweden. karin.manhem@hjl.gu.se
Ahlm
H
H
Dellborg
M
M
Milsom
I
I
D000279:Administration, Cutaneous; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy*; D017698:Postmenopause
D004958:Estradiol