title: NdWFamide: a novel excitatory peptide involved in cardiovascular regulation of Aplysia.
abstract: Although diverse peptides are known to affect invertebrate cardiac activity, the peptidergic regulation of the cardiovascular system of Aplysia is still poorly understood. Asn-D-Trp-Phe-NH(2) (NdWFamide) is a recently purified cardioactive peptide in Aplysia. Pharmacological experiments showed that NdWFamide was one of the most potent cardioexcitatory peptides among the known endogenous cardioactive peptides in Aplysia. NdWFamide-immunopositive neuronal processes were abundant in the cardiovascular region of Aplysia, and many of them originated from neurosecretory cells in the abdominal ganglion (R3-R13 cells). The data suggest that NdWFamide is a cardioexcitatory peptide utilized by R3-R13 cells of Aplysia.
authors.affiliation: Department of Biological Science, Faculty of Science, Hiroshima University Kagamiyama 1-3-1, Higashi-Hiroshima 739-8526, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Morishita
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Kanemaru
authors.forename: Y
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: O
authors.initials: O
authors.lastname: Matsushima
authors.forename: Y
authors.initials: Y
authors.lastname: Furukawa
mesh_terms: D000818:Animals; D001048:Aplysia / Q000502:physiology*; D002319:Cardiovascular System / Q000294:innervation / Q000378:metabolism*; D005724:Ganglia / Q000502:physiology; D007150:Immunohistochemistry; D009842:Oligopeptides / Q000378:metabolism*
chemical_list: D009842:Oligopeptides; C109335:asparaginyl-tryptophyl-phenylalaninamide