Pro-inflammatory cytokine production by synoviocytes following exposure to protein I/II, a modulin from oral streptococci.
We have tested the ability of protein I/II, an adhesin from oral streptococci, to stimulate the production of pro-inflammatory cytokines by synovial cells isolated from both rheumatoid arthritis and control patients. Protein I/II triggers synovial fluid cells to produce interleukin (IL)-6 and IL-8 while secretion of tumor necrosis factor-alpha (TNF-alpha) was less enhanced. Using fibroblast-like synoviocytes, we found that protein I/II also exerts an immunomodulatory effect (IL-6 and IL-8 release) on these cells. These findings indicate that, if it gains access to the joint cavity, protein I/II could participate in the initiation and/or perpetuation of rheumatic diseases, by stimulating pro-inflammatory cytokine release from various synovial cells.
Gourieux
B
B
INSERM U392, Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, Illkirch, France.
Al-Okla
S
S
Schöller-Guinard
M
M
Klein
J
J
Sibilia
J
J
Wachsmann
D
D
D018829:Adhesins, Bacterial / Q000235:genetics / Q000276:immunology*; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000503:physiopathology*; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000276:immunology; D013295:Streptococcus mutans / Q000378:metabolism*; D013582:Synovial Fluid / Q000166:cytology / Q000276:immunology*
D018829:Adhesins, Bacterial; D016207:Cytokines; D011994:Recombinant Proteins