title: Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease.
abstract: A 5-bp deletion and a Val1000 polymorphism at the alpha(2)-macroglobulin (A2M) gene have recently been reported to be associated with late onset Alzheimer's disease (AD). As recently it has been suggested that the effect of the A2M gene on AD susceptibility may be limited to certain populations or families, we analyzed the segregation of A2M and apolipoprotein E polymorphisms in Italian sporadic and familial AD. We analyzed the two polymorphisms in a total of 346 subjects including 98 controls by polymerase chain reaction-restriction fragment length polymorphism method. Our data do not confirm these associations, in particular we found a significant decrease of the deletion allele in AD with respect to controls. Our data do not support a role for the A2M gene as genetic risk factor for AD.
authors.affiliation: Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Nacmias
authors.forename: A
authors.initials: A
authors.lastname: Tedde
authors.forename: E
authors.initials: E
authors.lastname: Cellini
authors.forename: P
authors.initials: P
authors.lastname: Forleo
authors.forename: A
authors.initials: A
authors.lastname: Orlacchio
authors.forename: B M
authors.initials: BM
authors.lastname: Guarnieri
authors.forename: C
authors.initials: C
authors.lastname: Petruzzi
authors.forename: F
authors.initials: F
authors.lastname: D'Andrea
authors.forename: A
authors.initials: A
authors.lastname: Serio
authors.forename: S
authors.initials: S
authors.lastname: Sorbi
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D000511:alpha-Macroglobulins / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D000511:alpha-Macroglobulins