title: Effect of the treatment of Helicobacter pylori infection on gastric emptying and its influence on the glycaemic control in type 1 diabetes mellitus.
abstract: Helicobacter pylori (Hp) infection plays a role in gastric emptying (GE) in type 1 diabetic patients and may have implications for glycaemic control. The aim of our study was to investigate this relationship. Gastric emptying was studied in 13 patients with type 1 diabetes and Hp infection. The Hp infection status was assessed by serology and urease breath test (UBT). In addition upper gastrointestinal endoscopy with gastric mucosal biopsy was performed to look for gastritis. A radionuclide-labeled solid meal was used to study GE before and after eradication therapy (amoxicillin, clarithromycin and omeprazole) for Hp infection. All patients were evaluated for autonomic and peripheral neuropathy and were asked for symptoms of gastrointestinal motor dysfunction. Blood glucose levels were determined before the meal and at 30,60,90 and 120 min after the start of the meal. Home blood glucose self-monitoring and HbA(1c) were performed to document glycaemic control during the study. Three months after treatment, five patients were free of Hp infection and were without gastritis (group I: no Hp infection, no gastritis); eight of the patients continued to have gastritis after treatment (group II) and of these eight patients, six had gastritis without Hp infection and two had gastritis plus persistent Hp infection. These last two patients were re-treated with eradication therapy. Patients with gastritis were re-evaluated 6 months after initial treatment; at which time four were now free of gastritis and were added to group I (n=9) while four continual to have gastritis although without Hp infection (group II, n=4). In group I, GE half-time showed an increase (30.6+/-10.3 min vs. 60.2+/-15.4 min; P<0.05) while no change (28.8+/-9.5 vs. 26.9+/-8.7 min; n.s.) was observed in group II. GE half-time was not altered by autonomic and peripheral neuropathy or blood glucose during solid meal test. HbA(1c) did not change significantly after treatment in either groups but the blood glucose levels were more stable in group I compared to group II. A delay in GE was observed with disappearance of gastritis associated to H. pylori infection after eradication treatment in patients with type 1 diabetes. This change in GE could help to stabilise the blood glucose levels in these patients treated with insulin before each meal.
authors.affiliation: Department of Endocrinology, Institute of Endocrinology and Nutrition, Hospital Rio Hortega, Valladolid, Spain. ddlr@pulso.com
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: J M
authors.initials: JM
authors.lastname: Cordero
authors.forename: C
authors.initials: C
authors.lastname: Caballero
authors.forename: D
authors.initials: D
authors.lastname: Boixeda
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.forename: R
authors.initials: R
authors.lastname: Cantón
authors.forename: H
authors.initials: H
authors.lastname: de la Calle
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D017291:Clarithromycin / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000503:physiopathology*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005746:Gastric Emptying; D005756:Gastritis / Q000382:microbiology / Q000503:physiopathology; D006442:Glycated Hemoglobin / Q000032:analysis; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D016480:Helicobacter pylori; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009853:Omeprazole / Q000627:therapeutic use
chemical_list: D000658:Amoxicillin; D000907:Antibodies, Bacterial; D001786:Blood Glucose; D017291:Clarithromycin; D006442:Glycated Hemoglobin; D007074:Immunoglobulin G; D009853:Omeprazole