Role of 5-HT(1A) and 5-HT(1B) receptors in the mediation of behavior in the forced swim test in mice.
The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT(1A) agonist 8-OH-DPAT decreased immobility in the forced swim test in mice as previously described. Both the selective 5-HT(1B) agonist anpirtoline (1.25-5 mg/kg) and mixed 5-HT(1A/B) agonist RU24969 (0.6-2.5 mg/kg) significantly increased time spent swimming in the FST.
O'Neill
M F
MF
Lilly Research Centre, Eli Lilly & Co, Surrey, UK. oneill_michael_f@lilly.com
Conway
M W
MW
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007099:Imipramine / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D010069:Oxadiazoles / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013550:Swimming / Q000502:physiology
D000929:Antidepressive Agents, Tricyclic; D007211:Indoles; D010069:Oxadiazoles; D010879:Piperazines; D010880:Piperidines; D011725:Pyridines; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; C090701:GR 127935; C075631:anpirtoline; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007099:Imipramine