Basilar artery thrombosis in a child heterozygous for factor V Leiden mutation.
Activated protein C resistance, usually because of factor V Leiden mutation, is considered to be the most common hereditary prothrombotic condition. A 9-year-old male with a basilar artery stroke and activated protein C resistance is described. The patient, found to be heterozygous for factor V Leiden mutation, is one of several recent reports that suggest that activated protein C resistance is an important risk factor for spontaneous arterial thrombosis in infancy and childhood.
Verdú
A
A
Pediatric Neurology Unit, Hospital Virgen de la Salud, Toledo, Spain.
Cazorla
M R
MR
Granados
M A
MA
Alonso
J A
JA
Casado
L F
LF
D020016:Activated Protein C Resistance / Q000175:diagnosis / Q000235:genetics*; D001488:Basilar Artery / Q000473:pathology; D002533:Cerebral Angiography; D002648:Child; D005165:Factor V / Q000235:genetics*; D006580:Genetic Carrier Screening; D006801:Humans; D020766:Intracranial Embolism / Q000175:diagnosis / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male
C095381:factor V Leiden; D005165:Factor V