Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection.
In an attempt to determine why high frequencies of circulating virus-specific CD8+ T cells are unable to control human immunodeficiency virus and simian immunodeficiency virus (SIV) replication, we assessed the functional nature of SIV-specific CD8+ lymphocytes. After vaccination and early after infection, nearly all tetramer-staining CD8+ cells produced gamma interferon in response to their specific stimulus. However, by 4 months postinfection with pathogenic SIVmac239, signs of functional impairment in the CD8+ T-cell compartment were detected which might prevent these T cells from efficiently controlling the infection during the chronic phase.
Vogel
T U
TU
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715 , USA.
Allen
T M
TM
Altman
J D
JD
Watkins
D I
DI
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D008253:Macaca mulatta; D018449:SAIDS Vaccines / Q000008:administration & dosage / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
D018449:SAIDS Vaccines; D007371:Interferon-gamma