title: Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: a possible mechanism of the garlic induced hypotension.
abstract: Serum collected from unilaterally clipped and unclipped rats before and after treatment with water, garlic or cilazapril and subsequent to measuring blood pressure was assayed for thromboxane-B2 and prostaglandin-E2. The unclipped rats' thromboxane-B2 and prostaglandin-E2 levels were about 23 ng/ml and 2 ng/ml, respectively, and blood pressure was 126+/-3 mmHg. These values were not affected by either water or garlic administration. The clipped rats' thromboxane-B2 and prostaglandin-E2 concentrations were close to 34 ng/ml and 4 ng/ml, respectively, and declined only in response to garlic (by 15 ng/ml and 3 ng/ml) and cilazapril (by 12 ng/ml and 1.5 ng/ml). The blood pressure of these rats was 196+/-7 mmHg and again was reduced only by garlic to 169+/-14 mmHg and cilazapril to 137+/-5 mmHg. The no-treatment and water-treatment readings were significantly higher in the clipped rats. The data suggest that prostanoid system activity in the 2-kidney 1-clip rat is enhanced and mostly toward maintaining the hypertension. Furthermore, the blood pressure lowering effects of garlic and cilazapril might have been induced partially by a greater reduction in the synthesis of vasoconstrictor prostanoids.
authors.affiliation: Department of Biological Sciences, Faculty of Science, Kuwait University, P.O. Box 5969, Al-Safat 13060, Kuwait. qattan@kuc01.kuniv.edu.kw
authors.forename: K K
authors.initials: KK
authors.lastname: Al-Qattan
authors.forename: I
authors.initials: I
authors.lastname: Khan
authors.forename: M A
authors.initials: MA
authors.lastname: Alnaqeeb
authors.forename: M
authors.initials: M
authors.lastname: Ali
mesh_terms: D000818:Animals; D017315:Cilazapril / Q000494:pharmacology; D015232:Dinoprostone / Q000097:blood*; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D005737:Garlic / Q000627:therapeutic use; D006978:Hypertension, Renovascular / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013929:Thromboxane B2 / Q000097:blood*; D013997:Time Factors; D014867:Water / Q000494:pharmacology
chemical_list: D014867:Water; D017315:Cilazapril; D013929:Thromboxane B2; D015232:Dinoprostone