Inhibition of rubella virus growth by Fungizone.
Fungizone added to agar overlay medium inhibited plaque formation in both size and number by rubella virus in rabbit kidney 13 cells. In the presence of 1 microg/ml of Fungizone, the diameter of the plaques was reduced to one half of that in the absence of the drug, and at 5 microg/ml, plaque formation was inhibited by 80%. When the drug was added to the culture medium, the growth of infectious virus was also inhibited with reduction in the synthesis of envelope glycoprotein E1 and capsid protein C in infected cells.
Umino
Y
Y
Department of Viral Diseases and Vaccine Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, 208-0011, Tokyo, Japan.umino@nih.go.jp
Tashiro
M
M
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002213:Capsid / Q000096:biosynthesis; D002460:Cell Line; D011817:Rabbits; D012412:Rubella virus / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D014758:Viral Core Proteins / Q000096:biosynthesis; D014759:Viral Envelope Proteins / Q000096:biosynthesis; D010948:Viral Plaque Assay; D014776:Virus Cultivation
D000900:Anti-Bacterial Agents; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins; C074573:nucleocapsid protein (C), rubella virus; C061826:E1 envelope protein, Rubella virus; D000666:Amphotericin B