title: Long-term weight loss and changes in blood pressure: results of the Trials of Hypertension Prevention, phase II.
abstract: BACKGROUND
  Weight loss appears to be an effective method for primary prevention of hypertension. However, the long-term effects of weight loss on blood pressure have not been extensively studied.
  
  
  OBJECTIVE
  To present detailed results from the weight loss arm of Trials of Hypertension Prevention (TOHP) II.
  
  
  METHODS
  Multicenter, randomized dinical trial testing the efficacy of lifestyle interventions for reducing blood pressure over 3 to 4 years. Participants in TOHP II were randomly assigned to one of four groups. This report focuses only on participants assigned to the weight loss (n = 595) and usual care control (n = 596) groups.
  
  
  METHODS
  Men and women 30 to 54 years of age who had nonmedicated diastolic blood pressure of 83 to 89 mm Hg and systolic blood pressure less than 140 mm Hg and were 110% to 165% of their ideal body weight at baseline.
  
  
  METHODS
  The weight loss intervention included a 3-year program of group meetings and individual counseling focused on dietary change, physical activity, and social support
  
  
  METHODS
  Weight and blood pressure data were collected every 6 months by staff who were blinded to treatment assignment
  
  
  RESULTS
  Mean weight change from baseline in the intervention group was -4.4 kg at 6 months, -2.0 kg at 18 months, and -0.2 kg at 36 months. Mean weight change in the control group at the same time points was 0.1, 0.7, and 1.8 kg. Blood pressure was significantly lower in the intervention group than in the control group at 6, 18, and 36 months. The risk ratio for hypertension in the intervention group was 0.58 (95% CI, 0.36 to 0.94) at 6 months, 0.78 (CI, 0.62 to 1.00) at 18 months, and 0.81 (CI, 0.70 to 0.95) at 36 months. In subgroup analyses, intervention participants who lost at least 4.5 kg at 6 months and maintained this weight reduction for the next 30 months had the greatest reduction in blood pressure and a relative risk for hypertension of 0.35 (CI, 0.20 to 0.59).
  
  
  CONCLUSIONS
  Clinically significant long-term reductions in blood pressure and reduced risk for hypertension can be achieved with even modest weight loss.
authors.affiliation: Kaiser Permanente Center for Health Research, Portland, Oregon 97227, USA. victor.j.stevens@kpchr.org
authors.forename: V J
authors.initials: VJ
authors.lastname: Stevens
authors.forename: E
authors.initials: E
authors.lastname: Obarzanek
authors.forename: N R
authors.initials: NR
authors.lastname: Cook
authors.forename: I M
authors.initials: IM
authors.lastname: Lee
authors.forename: L J
authors.initials: LJ
authors.lastname: Appel
authors.forename: D
authors.initials: D
authors.lastname: Smith West
authors.forename: N C
authors.initials: NC
authors.lastname: Milas
authors.forename: M
authors.initials: M
authors.lastname: Mattfeldt-Beman
authors.forename: L
authors.initials: L
authors.lastname: Belden
authors.forename: C
authors.initials: C
authors.lastname: Bragg
authors.forename: M
authors.initials: M
authors.lastname: Millstone
authors.forename: J
authors.initials: J
authors.lastname: Raczynski
authors.forename: A
authors.initials: A
authors.lastname: Brewer
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: J
authors.initials: J
authors.lastname: Cohen
mesh_terms: D000328:Adult; D001521:Behavior Therapy; D001794:Blood Pressure / Q000502:physiology*; D003376:Counseling; D004032:Diet; D015444:Exercise; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011322:Primary Prevention; D012044:Regression Analysis; D012307:Risk Factors; D012944:Social Support; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*