Spinal cord lesions of myelitis with hyperIgEemia and mite antigen specific IgE (atopic myelitis) manifest eosinophilic inflammation.
We report the neuropathological findings of spinal cord specimens obtained from two patients who had localized myelitis with hyperIgEemia and mite antigen specific IgE (atopic myelitis). Both cases showed mild spinal cord dysfunction, and the gadolinium-enhanced area of the isolated spinal cord lesion observed on MRI was biopsied, respectively. Neuropathologically, both cases showed many perivascular lymphocyte cuffings associated with disrupted vessels, and the infiltration of eosinophils in the spinal cord lesions. Both myelin and axons were lost in the lesions, which were associated with astrogliosis. These findings suggest that an allergic mechanism may play a role in this condition.
Kikuchi
H
H
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 812-8582, Fukuoka, Japan.
Osoegawa
M
M
Ochi
H
H
Murai
H
H
Horiuchi
I
I
Takahashi
H
H
Yamabe
K
K
Iwaki
T
T
Mizutani
T
T
Oda
M
M
Kira
J
J
D000328:Adult; D000941:Antigens / Q000378:metabolism; D002574:Cervical Vertebrae; D004804:Eosinophils / Q000378:metabolism*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000473:pathology*; D007073:Immunoglobulin E / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D009187:Myelitis / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*
D000941:Antigens; D007073:Immunoglobulin E