One-trial conditioning of the antibody response to hen egg lysozyme in rats.
In Wistar rats, reexposure to a novel conditioned stimulus (CS) previously paired with a protein antigen, hen egg lysozyme (HEL) on a single conditioning trial increased anti-HEL IgG levels relative to conditioned rats that were not reexposed to the CS, conditioned rats that were preexposed to the CS, and nonconditioned rats. These results confirm previous findings that a single exposure to a CS associated with immunization is sufficient to elicit an antibody response upon subsequent reexposure to the CS in the absence of exogenous antigen.
Madden
K S
KS
Center for Psychoneuroimmunology Research, Departments of Psychiatry, Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, 300 Crittenden Blvd., Rochester, NY, USA. Kelley_Madden@urmc.rochester.edu
Boehm
G W
GW
Lee
S C
SC
Grota
L J
LJ
Cohen
N
N
Ader
R
R
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D003213:Conditioning, Psychological / Q000502:physiology*; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009113:Muramidase / Q000276:immunology*; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013997:Time Factors
D000906:Antibodies; D007074:Immunoglobulin G; C421864:hen egg lysozyme; D009113:Muramidase