title: Steroidal saponins from the leaves of Cestrum sendtenerianum.
abstract: Five steroidal saponins were isolated from the EtOH extract of Cestrium sendtenerianum (Solanaceae), as confirmed by detailed analysis of their 1H, 13C, and two-dimensional NMR spectral data, and by the results of hydrolytic cleavage. The saponins were revealed to contain three hydroxyl groups at the C-1beta, C-2alpha, and C-3beta positions in the spirostanol skeleton, and to bear a di- or triglycoside at C-3 as the common structural features. One of the compounds, a spirostanol triglycoside, showed weak cytotoxic activity on HL-60 human promyelocytic leukemia cells, with an IC50 value of 7.7 microg/ml.
authors.affiliation: Centro de Sanidade Animal, Instituto Biológico, São Paulo, SP, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Haraguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Mimaki
authors.forename: M
authors.initials: M
authors.lastname: Motidome
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Takeya
authors.forename: H
authors.initials: H
authors.lastname: Itokawa
authors.forename: A
authors.initials: A
authors.lastname: Yokosuka
authors.forename: Y
authors.initials: Y
authors.lastname: Sashida
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D019657:Solanaceae / Q000737:chemistry*; D013057:Spectrum Analysis; D013256:Steroids / Q000737:chemistry*
chemical_list: D012503:Saponins; D013256:Steroids