Serotonin 2A receptor-like immunoreactivity is detected in astrocytes but not in oligodendrocytes of rat spinal cord.
The distribution of the serotonin 2A (5-HT2A) receptor in glial cells in the white matter of rat spinal cord was immunohistochemically examined with specific antibodies against the 5-HT2A receptor. 5-HT2A receptor-like immunoreactivity was detected in astrocytes that were identified by an antibody against the glial fibrillary acidic protein. In contrast, 5-HT2A receptor-like immunoreactivity was not observed in oligodendrocytes.
Maxishima
M
M
Neurobiology Laboratory, Institute of Basic Medical Sciences, University of Tsukuba, 305-8575, Tsukuba, Japan.
Shiga
T
T
Shutoh
F
F
Hamada
S
S
Maeshima
T
T
Okado
N
N
D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D009836:Oligodendroglia / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin