title: Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men.
abstract: We examined the relation of serum lipids and apolipoprotein E genotype to colorectal adenomas among 205 cases and 220 controls with normal colonoscopy in Japanese men. With adjustment for body mass index, cigarette smoking, alcohol use, and other covaiates, odds ratios of proximal and distal adenomas associated with the presence of an allele varepsilon4 were 0.59 (95% confidence interval 0.23-1.45) and 0.99 (0.50-1.98), respectively. While serum total and LDL cholesterol were unrelated to both proximal and distal adenomas, serum triglycerides were positively related to distal adenomas. The findings suggest that altered lipid metabolism may be differentially associated with tumorigenesis in the proximal and distal colorectum.
authors.affiliation: Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. shinomi@phealth.med.kyushu-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Shinomiya
authors.forename: J
authors.initials: J
authors.lastname: Sasaki
authors.forename: C
authors.initials: C
authors.lastname: Kiyohara
authors.forename: E
authors.initials: E
authors.lastname: Tsuji
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Marugame
authors.forename: K
authors.initials: K
authors.lastname: Handa
authors.forename: H
authors.initials: H
authors.lastname: Hayabuchi
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: H
authors.initials: H
authors.lastname: Eguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Fukushima
authors.forename: S
authors.initials: S
authors.lastname: Kono
mesh_terms: D000236:Adenoma / Q000097:blood* / Q000235:genetics*; D000428:Alcohol Drinking; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000097:blood* / Q000235:genetics*; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood*; D008297:Male; D016017:Odds Ratio; D012907:Smoking; D014280:Triglycerides / Q000097:blood
chemical_list: D001057:Apolipoproteins E; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol