Delayed behavioral effects of beta-casomorphin-7 depend on age and gender of albino rat pups.
Systemic administration of beta-casein heptapeptide beta-casomorphin-7 (YPFPGPI, 1 mg/kg daily) to 10-23-day-old albino rat pups produced delayed anxiolytic effects, which were more pronounced in female than in male rats. Experimental findings confirm our assumption on the important role of nutritional opioids in brain development in newborn mammals.
Dubynin
V A
VA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia. dubynin@5.human.bio.msu.ru
Malinovskaya
I V
IV
Ivleva
Y A
YA
Andreeva
L A
LA
Kamenskii
A A
AA
Ashmarin
I P
IP
D000161:Acoustic Stimulation; D000367:Age Factors; D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism / Q000494:pharmacology*; D004723:Endorphins / Q000378:metabolism / Q000494:pharmacology*; D004924:Escape Reaction / Q000187:drug effects*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009294:Narcotics / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013312:Stress, Physiological
D014151:Anti-Anxiety Agents; D004723:Endorphins; D009294:Narcotics; D010446:Peptide Fragments; C041128:beta-casomorphin 7