title: Should adjuvant radiotherapy be recommended following resection of regional lymph node metastases of malignant melanomas?
abstract: BACKGROUND
  Several authors have recommended adjuvant radiotherapy following resection of regional lymph node metastases in cutaneous malignant melanoma. There is, however, little evidence from controlled trials that patients benefit from this treatment.
  
  
  OBJECTIVE
  To evaluate the usefulness of adjuvant radiotherapy following resection of lymph node metastases in cutaneous malignant melanoma.
  
  
  METHODS
  We performed a retrospective study comparing 58 patients who underwent radiotherapy following resection of regional lymph node metastases with 58 controls from another centre who exclusively underwent regional lymphadenectomy. Patients and their controls were matched with respect to the number of tumour-bearing lymph nodes (1 vs. > 1) and to gender, although the proportion of thick tumours was greater in the irradiation group.
  
  
  RESULTS
  The overall survival curves were almost identical in the two groups. There were nine disease recurrences in the study group and 12 in the control group (not significant). Regional recurrences in the irradiated patients were usually accompanied by metastases at other sites.
  
  
  CONCLUSIONS
  The present study does not support the recommendation of adjuvant radiotherapy following resection of regional lymph node metastases in patients with malignant melanoma.
authors.affiliation: Fachklinik Hornheide, Dorbaumstrasse 300, D-48157 Münster, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Fuhrmann
authors.forename: A
authors.initials: A
authors.lastname: Lippold
authors.forename: F
authors.initials: F
authors.lastname: Borrosch
authors.forename: U
authors.initials: U
authors.lastname: Ellwanger
authors.forename: C
authors.initials: C
authors.lastname: Garbe
authors.forename: L
authors.initials: L
authors.lastname: Suter
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis / Q000532:radiotherapy; D008297:Male; D008545:Melanoma / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D015996:Survival Rate; D016896:Treatment Outcome