Recalcitrant necrobiotic xanthogranuloma responding to pulsed high-dose oral dexamethasone plus maintenance therapy with oral prednisolone.
A patient with the rare condition necrobiotic xanthogranuloma was treated from 1992 to 1999 with multiple therapies, none of which was effective. Her disease was progressive, causing significant disability. In September 1999 a trial of high-dose pulsed oral dexamethasone with maintenance corticosteroids led to a substantial improvement in her condition.
Chave
T A
TA
Department of Dermatology, University Hospital of Wales, Cardiff CF14 4XN, UK. Toby@Chave.fsbusiness.co.uk
Chowdhury
M M
MM
Holt
P J
PJ
D000368:Aged; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006099:Granuloma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D017441:Necrobiotic Disorders / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D014973:Xanthomatosis / Q000188:drug therapy* / Q000473:pathology
D005938:Glucocorticoids; D003907:Dexamethasone; D011239:Prednisolone