Neurochemical characteristics of the effects of delta sleep-inducing peptide in Wistar rats with hyperactivity of the dopaminergic system.
Quantitative cytochemical assay showed that single injection of delta sleep-inducing peptide increased monoamine oxidase activity (substrates: serotonin and tryptamine) in the caudate and accumbens nuclei and glutamate dehydrogenase activity in the hippocampus of stress-resistant Wistar rats chronically treated with L-DOPA. Enzyme activities in the sensorimotor cortex did not change. Delta sleep-inducing peptide had no effects on acetylcholine esterase and aminopeptidase activities in the brain of Wistar rats.
Sergutina
A V
AV
Laboratory of Cytochemistry, Institute of Brain Research, Russian Academy of Medical Sciences, Moscow, Russia.
Gershtein
L M
LM
D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000201:enzymology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D007980:Levodopa / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism; D009044:Motor Cortex / Q000187:drug effects; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar
D018377:Neurotransmitter Agents; D007980:Levodopa; D003701:Delta Sleep-Inducing Peptide; D005969:Glutamate Dehydrogenase; D008995:Monoamine Oxidase; D000626:Aminopeptidases