title: Clinically relevant rat model for testing BOLD functional MR imaging techniques by using single-shot echo-planar imaging at 1.5 T.
abstract: By using a 1.5-T whole-body magnetic resonance (MR) imager, a high-spatial-resolution single-shot echo-planar technique was developed to perform blood oxygen level dependent functional MR imaging of rat sensory cortex during forepaw stimulation. This technique produced cubic 1-mm(3) voxels. Signal-to-noise ratio was 140-160 (43-44 dB). Optimal effective echo time was 50 msec. This system should prove useful for developing new functional MR imaging techniques with rapid adaptation to human use.
authors.affiliation: Departments of Radiology, University of Washington, 1959 NE Pacific St, Box 357115, Seattle, WA 98195, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Morton
authors.forename: K R
authors.initials: KR
authors.lastname: Maravilla
authors.forename: J R
authors.initials: JR
authors.lastname: Meno
authors.forename: H R
authors.initials: HR
authors.lastname: Winn
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010100:Oxygen