Topical tacrolimus.
Tacrolimus, available for intravenous, oral and now topical administration, is a potent immunosuppressive agent with the ability to block the production of Interleukin-2 (IL-2) and inhibit T-cell proliferation. Originally developed for use in organ transplantation, it is currently being studied for the treatment of inflammatory dermatoses. The US FDA recently approved tacrolimus ointment (Protopic (R), Fujisawa) for the treatment of atopic dermatitis.
Frankel
S J
SJ
Department of Dermatology, University of Miami School Of Medicine, Miami, Florida, USA.
Kerdel
F A
FA
D000287:Administration, Topical; D002986:Clinical Trials as Topic; D003872:Dermatitis / Q000188:drug therapy*; D004347:Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D014481:United States
D007166:Immunosuppressive Agents; D016559:Tacrolimus