Discoid lupus erythematosus (DLE)-like lesion induced by uracil-tegafur (UFT).
A mixture of uracil and tegafur (UFT) is a common antineoplastic agent in Japan. We report a 64-year-old Japanese woman with discoid lupus erythematosus (DLE)-like lesions which were induced by UFT. After surgery to treat lung cancer, UFT (300 mg/day) was administered and she developed round erythema on her right cheek. A skin biopsy specimen taken from the right cheek site revealed atrophy of the epidermis, a slight liquefaction of the basal cell layer, and patchy lymphocytic infiltration in the perivascular and perifollicular regions. A test for antinuclear antibody was weakly positive (80 fold), and rheumatoid factor was slightly elevated (7.6 IU/ml). After discontinuation of UFT, the erythema completely regressed within 2 months. We reviewed 17 cases of DLE-like lesions induced by fluorouracil agents and summarized the common features.
Yoshimasu
T
T
Department of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-0012 Japan.
Hiroi
A
A
Uede
K
K
Furukawa
F
F
D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002610:Cheek; D017024:Chemotherapy, Adjuvant; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005148:Facial Dermatoses / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis; D008875:Middle Aged; D005641:Tegafur / Q000009:adverse effects*; D014498:Uracil / Q000009:adverse effects*
D000964:Antimetabolites, Antineoplastic; D005641:Tegafur; D014498:Uracil