[Analysis of regions determining resistence to fluoroquinolones in genes gyrA and parC in clinical isolates of Mycoplasma hominis].
Fifteen strains of M. hominis isolated from patients with urogenital inflammations were analyzed. Variations in the quinolone resistance-determining regions (QRDR) have been found in fluoroquinolone-resistant M. hominis clinical isolates in comparison with the reference PG21 strain. In one isolate, parC had Asn substitute at position 91.
Gushchin
A E
AE
Laboratory of Gene Engineering and Immunogenetics, Institute of Physico-Chemical Medicine, Ministry of Health of Russian Federation, Moscow, St. Petersburg.
Ladygina
V G
VG
Govorun
V M
VM
Taraskina
A M
AM
Savicheva
A M
AM
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001483:Base Sequence; D027081:DNA Gyrase; D017931:DNA Primers; D027101:DNA Topoisomerase IV; D004250:DNA Topoisomerases, Type II / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000235:genetics*; D024841:Fluoroquinolones; D019535:Mycoplasma hominis / Q000187:drug effects* / Q000235:genetics
D000890:Anti-Infective Agents; D017931:DNA Primers; D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase; D004250:DNA Topoisomerases, Type II