Is ApoE gene a risk factor for vascular dementia in Han Chinese?
We have compared the apolipoprotein E (ApoE) genotypes of Han Chinese with late-onset sporadic Alzheimer's disease (LOAD, n=191), and vascular dementia (VaD, n=124) to controls (n=218) with a similar age distribution. The frequency of ApoE epsilon4 allele in the LOAD group was significantly higher than that in the control group (30.1% versus 10.55%, p<10-7). The risk rate of LOAD was 3.5 times higher for carriers with at least one ApoE epsilon4 allele than for non-epsilon4 bearing controls. ApoE epsilon4 allele was also significantly associated with vascular dementia (OR=1.75, p=0.026). Our findings support previous reports of a positive association between ApoE epsilon4 and both Alzheimer's disease and vascular dementia in Han Chinese.
Yang
J
J
Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, P.R. China.
Feng
G
G
Zhang
J
J
Hui
Z
Z
Breen
G
G
St Clair
D
D
He
L
L
D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000209:etiology / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002681:China / Q000453:epidemiology; D015140:Dementia, Vascular / Q000209:etiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016555:Matched-Pair Analysis; D016017:Odds Ratio; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E