Neuroscience. An antibiotic to treat Alzheimer's?
An antibiotic once used to treat traveler's diarrhea might battle Alzheimer's disease as well, researchers announced here last week at the Society for Neuroscience's annual meeting. The drug dissolves Alzheimer's-like plaques in mouse brains, apparently by trapping the copper and zinc that stud these deposits. A clinical trial to test whether the drug helps people with Alzheimer's is already under way.
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D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D017322:Clinical Trials, Phase II as Topic; D007464:Clioquinol / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D003300:Copper / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D051379:Mice; D058225:Plaque, Amyloid / Q000187:drug effects* / Q000378:metabolism; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology
D016229:Amyloid beta-Peptides; D003300:Copper; D007464:Clioquinol; D015032:Zinc