Hemodynamic effects of tetrindol in alert normotensive mice and rats after blockade of nitric oxide synthesis.
Single intravenous injection of antidepressant tetrindol (1 and 10 mg/kg), a reversible monoamine oxidase A inhibitor, dose-dependently decreased heart rate and mean arterial pressure (in a concentration of 10 mg/kg) in alert NMRI mice and Sprague-Dawley rats. Nitric oxide synthase blockade with L-NAME attenuated tetrindol-induced bradycardia in rats and completely abolished this effect in mice.
Korshunov
V A
VA
Group of Pharmacology, Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow region.
Murashev
A N
AN
Ivashev
M N
MN
Dugin
S F
SF
Medvedev
O S
OS
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000928:Antidepressive Agents; D002227:Carbazoles; D004791:Enzyme Inhibitors; D008996:Monoamine Oxidase Inhibitors; C082644:tetrindole; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester