[Aberrant expression of immunoglobulin germline gene C mu in leukemias].
OBJECTIVE
To investigate the significance of immunoglobulin germline gene C mu expression in leukemias.


METHODS
Immunoglobulin germline gene C mu transcripts in 63 bone marrow samples from 59 leukemia patients were examined by RT-PCR.


RESULTS
Germline C mu transcripts could be identified in 17 of 26 AML, 9 of 12 ALL, 4 CML-BC and 2 CLL patients. HLA-DR was expressed in 80% C mu(+) patients and in 92.9% C mu(+) AML patients. In 10 normal bone marrow or peripheral blood samples C mu transcripts were undetectable.


CONCLUSIONS
Leukemogenesis in most acute leukemia may originate from the common progenitors of early B-lymphoid and myeloid cells.
Guo
M
M
Beijing North Taiping Road Hospital, Beijing 100039.
Dong
L
L
Huang
S
S
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000096:biosynthesis / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology*
D007148:Immunoglobulin mu-Chains