Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?
The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.
Labib
K
K
Chromosome Replication Laboratory, ICRF Clare Hall Laboratories, Blanche Lane, South Mimms, EN6 3LD, Hertfordshire, UK.labib@icrf.icnet.uk
Diffley
J F
JF
D000251:Adenosine Triphosphatases / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism*; D011485:Protein Binding; D053484:RecQ Helicases; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins; D029701:Saccharomyces cerevisiae Proteins; D000251:Adenosine Triphosphatases; C085463:PIF1 protein, S cerevisiae; C506724:RecQ protein, E coli; D004265:DNA Helicases; C410222:DNA2 protein, S cerevisiae; D053484:RecQ Helicases