title: Hypotension after coronary arterial occlusion induces regional expression of c-Fos protein in the rat brain.
abstract: The purpose of this study was to examine comprehensively and quantitatively the effects of sustained occlusion of the circumflex branch of the left coronary artery on neuronal expression of Fos, the protein product of the proto-oncogene c-fos, in the rat brain. Occlusion coronary artery induced a fall in mean arterial pressure of about 10-30%, maintained for a period of 60 min. Baroreceptors were activated by occlusion coronary artery-induced hypotension. In control rats treated with without coronary ligation, few Fos-positive cells were observed. Following coronary artery occlusion, there was a significant increase in the number of Fos-positive cells in the several brain regions. These brain regions containing Fos-positive neurons in rats treated with coronary artery occlusion included nucleus tractus solitarius (NTS), area postrema (AP), caudal and rostral ventrolateral medulla (VLM), lateral parabrachial nucleus (PBN), supraoptic nucleus (SON), paraventricular nucleus (PVN) and central nucleus of the amygdala (CE). This finding partly differs from previous studies where Fos expression occurred by other reasons such as hypovolemia, hemorrhage, nitroprusside or hydralazine etc. These results generally fit within an emerging understanding of brain circuitry underlying cardiovascular regulation.
authors.affiliation: Department of Anatomy, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan.
authors.forename: Q
authors.initials: Q
authors.lastname: Xie
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Kawada
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003327:Coronary Disease / Q000503:physiopathology*; D007022:Hypotension / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009474:Neurons / Q000378:metabolism; D011311:Pressoreceptors / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D016760:Proto-Oncogene Proteins c-fos