[Advances in research on the molecular pathogenesis of the malignant tumours and implications for their early diagnosis and treatment].
The present status of research on molecular mechanisms involved in the development and progression of human cancers is reviewed and major applications of molecular methods in early diagnosis and prediction of individual cancer treatment responses are discussed. The nature and mode of expression of hereditary traits resulting in cancer predispositions in children and adolescents is discussed in more detail, with emphasis on the contribution of recessive DNA repair defects, and on tumour spectra, risk of secondary cancers and of clinical relevance of molecular testing for germline defects of antioncogenes and oncogenes.
Steffen
J
J
Zaklad Immunologii, Centrum Onkologii - Instytut im. M. Sklodowskiej - Curie w Warszawie, ul. W.K.Roentgena 5, 02-781 Warszawa, Polska. jsteffen@coi.waw.pl
D000293:Adolescent; D002648:Child; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*