title: Fenbendazole treatment without environmental decontamination eradicates Syphacia muris from all rats in a large, complex research institution.
abstract: Syphacia muris parasitism was eliminated from rats and voles by feeding fenbendazole-medicated chow (150 ppm) for five 7-day periods; treatment periods were separated by 7-day periods of feeding non-medicated chow, yielding atotal treatment course of 9 weeks. No other manipulations to facilitate eradication, including the use of filter tops, autoclaved cages, environmental decontamination, colony depopulation, breeding cessation, and research restriction, were done. The examination of 3143 cellophane-tape impressions of the anus and 160 cecal examinations from euthanized rats and voles during the treatment period and for 7 months afterwards confirmed the efficacy of treatment. Treatment was rapidly effective in voles. In rats, pinworm eggs persisted at high levels for 2 weeks after the start of treatment, but no eggs were found after 22 days.
authors.affiliation: Division of Animal Resources, Emory University, Atlanta, GA 30322, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Huerkamp
authors.forename: K A
authors.initials: KA
authors.lastname: Benjamin
authors.forename: L A
authors.initials: LA
authors.lastname: Zitzow
authors.forename: J K
authors.initials: JK
authors.lastname: Pullium
authors.forename: J A
authors.initials: JA
authors.lastname: Lloyd
authors.forename: W D
authors.initials: WD
authors.lastname: Thompson
authors.forename: S K
authors.initials: SK
authors.lastname: Webb
authors.forename: N D
authors.initials: ND
authors.lastname: Lehner
mesh_terms: D001003:Anal Canal / Q000469:parasitology; D000821:Animal Feed; D000818:Animals; D000830:Animals, Laboratory; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003411:Arvicolinae; D006224:Cricetinae; D003666:Decontamination; D017229:Enterobiasis / Q000517:prevention & control / Q000662:veterinary*; D004757:Enterobius / Q000302:isolation & purification; D005273:Fenbendazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006799:Housing, Animal; D010270:Parasite Egg Count / Q000662:veterinary; D051381:Rats; D012376:Rodent Diseases / Q000469:parasitology / Q000517:prevention & control*
chemical_list: D000969:Antinematodal Agents; D005273:Fenbendazole