title: High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis.
abstract: To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twofold higher thrombopoietin levels and 20-fold higher reticulated platelet counts, but lower levels of glycocalicin in fetuses compared with their mothers (P < 0.05). Neither the expression of platelet glycoprotein Ib and IIb on platelets nor the platelet counts were different between mothers and their fetuses. These data indicate enhanced thrombopoiesis and/or increased platelet turnover in fetuses.
authors.affiliation: Clinic for Blood Group Serology and Transfusion Medicine, University of Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Jilma-Stohlawetz
authors.forename: M
authors.initials: M
authors.lastname: Homoncik
authors.forename: B
authors.initials: B
authors.lastname: Jilma
authors.forename: C C
authors.initials: CC
authors.lastname: Folman
authors.forename: A E
authors.initials: AE
authors.lastname: von dem Borne
authors.forename: G
authors.initials: G
authors.lastname: Bernaschek
authors.forename: J
authors.initials: J
authors.lastname: Deutinger
authors.forename: B
authors.initials: B
authors.lastname: Ulm
authors.forename: W
authors.initials: W
authors.lastname: Eppel
authors.forename: S
authors.initials: S
authors.lastname: Panzer
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry* / Q000166:cytology; D006410:Hematopoiesis; D006801:Humans; D007958:Leukocyte Count; D009504:Neutrophils / Q000166:cytology; D010975:Platelet Aggregation Inhibitors / Q000032:analysis; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000032:analysis; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013926:Thrombopoietin / Q000032:analysis*
chemical_list: D010975:Platelet Aggregation Inhibitors; D019038:Platelet Glycoprotein GPIb-IX Complex; C023592:glycocalicin; D013926:Thrombopoietin