title: Can cerebral blood volume be measured reproducibly with an improved near infrared spectroscopy system?
abstract: In some circumstances, cerebral blood volume (CBV) can be used as a measure for cerebral blood flow. A new near infrared spectroscope was used for determining the reproducibility of CBV measurements assessed by the O2-method. Twenty-seven healthy subjects were investigated. An intrasubject coefficient of variation (CV) was calculated, based on four identical episodes of desaturation-resaturation (O2-method) procedures for CBV measurements. Two trials were performed, with (trial 1) and without (trial 2) disconnecting the equipment. A mean CV of 12.6% and 10.0% was found in trial 1 and 2, respectively. Cerebral blood volume values yield 3.60+/-0.82 mL 100 g(-1). Cerebral blood volume could be measured reproducible in adults using near infrared spectroscopy, if the arterial desaturation is limited to approximately 5% from baseline level.
authors.affiliation: Department of Pulmonology Dekkerswald, University of Nijmegen, Groesbeek, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Van de Ven
authors.forename: W N
authors.initials: WN
authors.lastname: Colier
authors.forename: M C
authors.initials: MC
authors.lastname: van der Sluijs
authors.forename: D
authors.initials: D
authors.lastname: Walraven
authors.forename: B
authors.initials: B
authors.lastname: Oeseburg
authors.forename: H
authors.initials: H
authors.lastname: Folgering
mesh_terms: D000328:Adult; D001810:Blood Volume; D001921:Brain / Q000098:blood supply*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000032:analysis; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin