title: [Results of a therapeutic strategy against monosymptomatic nocturnal enuresis].
abstract: BACKGROUND
  There are many therapeutic options against enuresis.
  
  
  OBJECTIVE
  To evaluate several therapies introduced progressively to treat monosymptomatic nocturnal enuresis.
  
  
  METHODS
  Eighty-four patients, aged 6 to 14 years old, were studied. The 67 year olds were treated with desmopressin and oxybutynin was added in nonresponders. If enuresis persisted, Alarm was given. Children over 7 years of age were randomly divided and treated with Alarm or Alarm plus desmopressin. Nonresponders were treated with desmopressin alone.
  
  
  RESULTS
  In children aged 6-7 years the cumulative response was 72%. Those who wetted themselves less responded to desmopressin. In children over 7 years of age, response to Alarm was 73.3% and response to Alarm plus desmopressin was 58.6%. In nonresponders the cumulative response after desmopressin treatment increased to 80% and 62% respectively.
  
  
  CONCLUSIONS
  In the group of 6 to 7 year-olds desmopressin was indicated as first line therapy. Treatment efficacy was increased by adding oxybutynin especially in the children who wetted themselves the most. In children over 7 years of age Alarm was the most effective treatment and relapses were fewer. No advantages were observed with the combination of Alarm and desmopressin in our protocol.
authors.affiliation: Unidades de Nefrología Pediátrica. Departamentos de Pediatría. Complexo Hospitalario Cristal-Piñor. Orense. Hospital Clínico Universitario. Santiago de Compostela.
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez do Forno
authors.forename: G
authors.initials: G
authors.lastname: Ariceta Iraola
mesh_terms: D000293:Adolescent; D002648:Child; D003131:Combined Modality Therapy; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D004775:Enuresis / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000627:therapeutic use; D012076:Renal Agents / Q000627:therapeutic use
chemical_list: D008333:Mandelic Acids; D012076:Renal Agents; D003894:Deamino Arginine Vasopressin; C005419:oxybutynin