title: The DAPIN family: a novel domain links apoptotic and interferon response proteins.
abstract: We report the discovery of a protein domain, hereafter referred to as DAPIN, in diverse vertebrate and viral proteins that is associated with tumor biology, apoptosis and inflammation. Based on a secondary structure prediction, we suggest an all-alpha fold for DAPIN, which is also adopted by apoptotic protein domains of the CARD, death domain and death effector domain type.
authors.affiliation: metaGen Gesellschaft für Genomforschung mbH, 14195, Berlin, Germany. eike.staub@metagen.de
authors.forename: E
authors.initials: E
authors.lastname: Staub
authors.forename: E
authors.initials: E
authors.lastname: Dahl
authors.forename: A
authors.initials: A
authors.lastname: Rosenthal
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D005091:Exons; D006801:Humans; D007372:Interferons / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics
chemical_list: D014157:Transcription Factors; D007372:Interferons