[Role of biochemical indices as metastatic markers in patients with prostatic cancer invading skeleton].
Biochemical markers of resorption and formation of bone tissue (piridinoline-PD, desoxypiridinoline-DPD and alkaline phosphatase-AP, respectively) were measured in blood serum and urine of 41 prostatic cancer (PC) patients with metastases to the bones and 24 PC patients free of such metastases as well as of 40 healthy males and 11 males with benign prostatic hyperplasia (BPH). It was found that PD, DPD levels, general AP activity and activity of its bone fraction were significantly higher in PC patients with bone metastases than in the others (p < 0.001). The former had a significantly higher percent of peptide-bound and lower percent of free forms of PD and DPD (p < 0.001) vs patients without metastases and controls. Higher biochemical serum and urine indices in PC patients with bone metastases reflect enhanced intensity of both formation and resorption of bone tissue in PC with bone metastatic lesions. Therefore, it is possible to use PD, DPD and AP values in diagnosis and monitoring of metastatic skeletal destruction in PC.
Liubimova
N V
NV
Trapeznikova
M F
MF
Robins
S P
SP
Ognerubov
S A
SA
Kushlinskiĭ
N E
NE
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine; D001859:Bone Neoplasms / Q000097:blood / Q000175:diagnosis / Q000556:secondary* / Q000652:urine; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D012189:Retrospective Studies
D000596:Amino Acids; D014408:Biomarkers, Tumor; C015484:pyridinoline; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase