Water-soluble 99mTc-labeled dendritic novel porphyrins tumor imaging and diagnosis.
We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeled them with 99mTc. These 99mTc-labeled porphyrins were administered to C6-glioma tumor bearing Wistar rats and scintiimaging and biodistribution studies were carried out. Tumor to muscle ratios of DP1 and DP2 were 8.0 and 9.7, respectively. These molecules may have potential for tumor imaging and diagnosis and may even prove useful as photosensitizers in photodynamic therapy applications.
Subbarayan
M
M
Radiation Medicine Centre, Tata Memorial Hospital Annexe, Parel, Mumbai, 400 012, India.
Shetty
S J
SJ
Srivastava
T S
TS
Noronha
O P
OP
Samuel
A M
AM
Mukhtar
H
H
D000818:Animals; D000831:Animals, Newborn; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology; D005910:Glioma / Q000175:diagnosis / Q000473:pathology; D008024:Ligands; D008956:Models, Chemical; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D017319:Photosensitizing Agents / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis*; D051381:Rats; D017208:Rats, Wistar; D013667:Technetium; D014407:Tumor Cells, Cultured
D008024:Ligands; D017319:Photosensitizing Agents; D011166:Porphyrins; D013667:Technetium