Src family kinase function during early Xenopus development.
The Src family kinase Laloo functions downstream of the fibroblast growth factor (FGF) receptor, as a component of a signaling pathway required for mesoderm formation. In this study, we first show that Laloo expression can mimic FGF function in a distinct context, suggesting that the Src-related kinases are general transducers of FGF signaling during development. We then characterize the role of the SH-PTP2 phosphatase, and of bone morphogenetic protein (BMP)-pathway signaling, in mesoderm induction by Laloo. Finally, we demonstrate that the mesoderm-inducing activity of the Src family kinases is not limited to Laloo, indicating a degree of functional overlap between members of this gene family during early vertebrate development.
Weinstein
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DC
Department of Molecular Vertebrate Embryology, The Rockefeller University, New York, NY, USA. weinsd01@doc.mssm.edu
Hemmati-Brivanlou
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AA
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D008648:Mesoderm / Q000502:physiology*; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000502:physiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction; D014981:Xenopus / Q000196:embryology*; D029867:Xenopus Proteins; D018909:src Homology Domains; D019061:src-Family Kinases / Q000378:metabolism*
D019485:Bone Morphogenetic Proteins; C114358:HCK protein, Xenopus; D017468:Receptors, Fibroblast Growth Factor; D029867:Xenopus Proteins; D019061:src-Family Kinases