title: [Differentiated carcinoma of the thyroid in the young. Clinical and histopathologic aspects].
abstract: BACKGROUND
  The surgical approach to Differentiated Thyroid Carcinoma (DTC) is controversial. Aim of this study is to evaluate the opportunity of total thyroidectomy as treatment of choice for DTC in children.
  
  
  METHODS
  We examined the tumor features at diagnosis, the complications of surgery and the clinical outcome in a consecutive series of 33 young patients, (age range 7-19 yrs), who underwent total thyroidectomy for DTC as compared to a consecutive series of 181 adult patients operated for DTC (age range 20-64 yrs).
  
  
  RESULTS
  Histopathological examination has shown that bilateral foci of the tumor and extrathyroidal extension, were present with similar frequency in both groups of patients (15 vs 18% and 39 vs 48% respectively); node metastases and distant metastases were more frequent in young patients than in adult patients. Complications of total thyroidectomy were not frequent with 6% of permanent hypoparathyroidism. No case of laryngeal nerve damage was observed. In 7/8 patients with lung metastases the radioiodine treatment was effective: in four patients we observed a complete remission of disease, and in three patients a partial response with a decrease of Tg levels and a reduction of the radioiodine uptake areas.
  
  
  CONCLUSIONS
  Thyroid carcinoma is not less aggressive in children than in adults. Total thyroidectomy plus lymph node dissections appears to be the treatment of choice as routine surgical treatment of DTC in children. Radioiodine therapy gives good results for the treatment of lung metastases.
authors.affiliation: Istituto di Medicina Interna e di Malattie Endocrine e del Metabolismo, Università degli Studi, Catania.
authors.forename: M P
authors.initials: MP
authors.lastname: Iurato
authors.forename: C
authors.initials: C
authors.lastname: Scollo
authors.forename: A
authors.initials: A
authors.lastname: Belfiore
authors.forename: G
authors.initials: G
authors.lastname: Pellegriti
authors.forename: P
authors.initials: P
authors.lastname: Salice
authors.forename: V
authors.initials: V
authors.lastname: Pezzino
authors.forename: D
authors.initials: D
authors.lastname: Giuffrida
mesh_terms: D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D007011:Hypoparathyroidism / Q000209:etiology; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects*