title: Brucellosis in laboratory workers at a Saudi Arabian hospital.
abstract: BACKGROUND
  Saudi Arabia is hyperendemic for brucellosis, with more than 8000 cases reported each year to public health authorities. During 1998, brucellosis ranked as the No. 1 reportable communicable disease (22.5%) in Saudi Arabian National Guard communities. King Fahad Hospital is the major referral center for National Guard personnel in the nation's central region.
  
  
  RESULTS
  From 1991 to 2000, brucellosis developed in 7 expatriate hospital employees. Six employees were bacteriology technologists, and one was a pathologist. Each had a clinical syndrome compatible with brucellosis (headache, fever, rigors, sweats, and myalgias) plus elevated Brucella sp serum agglutinin titers > or = 1:1280; one patient also had positive blood cultures. All patients responded to anti-Brucella therapy. Two patients had relapses, and complications occurred in four patients (septic endophlebitis of the leg, infected prosthesis, epididymoorchitis, and lumbar spondylitis). In all these employees except the pathologist, the infection was associated with processing Brucella sp cultures.
  
  
  CONCLUSIONS
  Despite the enforcement of stringent infection control measures including the use of a class II biosafety hood in the laboratory, the problem of nosocomial brucellosis persists because of the large number of infected specimens handled by the laboratory (17,500 specimens per year). Ultimately, risk reduction depends on efforts to reduce disease endemicity in the country. In the meantime, conversion of the laboratory to biosafety level 3 is under way.
authors.affiliation: Department of Infection Prevention and Control, King Fahad National Guard Hospital, Riyadh, Saudi Arabia.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Memish
authors.forename: M W
authors.initials: MW
authors.lastname: Mah
mesh_terms: D000818:Animals; D017347:Brucella melitensis / Q000302:isolation & purification; D002006:Brucellosis / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D005260:Female; D006761:Hospitals; D006801:Humans; D017053:Infection Control; D007757:Laboratory Infection / Q000453:epidemiology* / Q000382:microbiology; D008297:Male; D017056:Medical Laboratory Personnel / Q000706:statistics & numerical data*; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D012529:Saudi Arabia / Q000453:epidemiology; D015047:Zoonoses