VEGF mRNA is unaltered in decidual and placental tissues in preeclampsia at delivery.
BACKGROUND
VEGF (vascular endothelial growth factor) is a growth factor which is central in blood vessel formation. We wanted to determine whether the mRNA levels of VEGF are altered in preeclampsia in decidual and placental tissues compared to control pregnancies.


METHODS
Decidua basalis was obtained by vacuum aspiration during cesarean section in 25 preeclamptic and 19 uneventful pregnancies. Placental biopsies were taken immediately after delivery. Relative mRNA levels of VEGF were quantified and compared to those of the housekeeping gene beta-actin.


RESULTS
No statistically significant differences in VEGF mRNA levels were found between the preeclampsia and the control group for either the decidual or placental tissues. Furthermore, there were no significant differences between VEGF mRNA levels in the preeclamptic and control group with respect to gestational age of the women.


CONCLUSIONS
This study provides no evidence of abnormal VEGF expression at delivery in decidua basalis or placenta in pregnancies complicated by preeclampsia.
Ranheim
T
T
Institute for Nutrition Research, Aker Hospital, Oslo, Norway.
Staff
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AC
Henriksen
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T
D000328:Adult; D015152:Blotting, Northern; D016022:Case-Control Studies; D003656:Decidua / Q000378:metabolism*; D016228:Endothelial Growth Factors / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008222:Lymphokines / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors