title: Electrolytic lesions of the medial septum enhance latent inhibition in a conditioned taste aversion paradigm.
abstract: The effects of medial septal lesions on latent inhibition (LI) were assessed in a conditioned taste aversion paradigm. Animals were tested in a LI paradigm 2 weeks after receiving medial septal or sham lesions. The LI paradigm involved a pre-exposure phase in which water-deprived rats were allowed access to either water (non-pre-exposed; NPE) or 5% sucrose (pre-exposed; PE), followed by a conditioning phase in which animals were allowed access to sucrose and subsequently injected with lithium chloride, and a test phase in which animals were allowed access to both sucrose and water. LI was assessed by comparing the %-sucrose consumed in PE and NPE groups on the test day. There was a significantly greater LI effect in the lesion group than in the sham group, suggesting that electrolytic lesions to the medial septum can enhance LI in a CTA paradigm.
authors.affiliation: Department of Psychology, Amherst College, Amherst, MA 01002, USA. smturgeon@amherst.edu
authors.forename: S M
authors.initials: SM
authors.lastname: Turgeon
authors.forename: G
authors.initials: G
authors.lastname: Kegel
authors.forename: M M
authors.initials: MM
authors.lastname: Davis
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology*; D003714:Denervation / Q000009:adverse effects; D004327:Drinking Behavior / Q000502:physiology; D004435:Eating / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology; D012686:Septal Nuclei / Q000033:anatomy & histology / Q000502:physiology* / Q000601:surgery; D013649:Taste / Q000502:physiology*