title: Osteoclastoma-like Giant Cell Tumor of the Lung.
abstract: The main components of an unusual form of lung tumor were osteoclast-like multinucleated giant cells and mononuclear stromal cells. Besides, scattered islands of moderately differentiated squamous cells also appeared. Both the mononuclear and the osteoclast-like giant cells reacted with antibodies against CD68 and vimentin, but did not react with antibodies against cytokeratin, EMA and CEA, or lysozyme and a-1-antitrypsin. The p53 and PCNA antigens were positive only in mononuclear cells and not the osteoclast-like giant cells, suggesting that mononuclear cells represent proliferating elements with histiocytic differentiation while osteoclast-like giant cells are stromal, presumably reactive components of the tumor.
authors.affiliation: National Institute of Oncology, Department of Human and Experimental Tumor Pathology, Budapest, Hungary.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Orosz
authors.forename: Erika
authors.initials: E
authors.lastname: Tóth
authors.forename: Anna
authors.initials: A
authors.lastname: Viski