title: Antiamnesic effect of acyl-prolyl-containing dipeptide (GVS-111) in compression-induced damage to frontal cortex.
abstract: Antiamnestic effect of acyl-prolyl-containing dipeptide GVS-111 was demonstrated in rats with bilateral compression-induced damage to the frontal cortex. Both intraperitoneal and oral administration of the dipeptide improved retrieval of passive avoidance responses in rats with compression-induced cerebral ischemia compared to untreated controls.
authors.affiliation: Institute of General Pathology and Pathophysiology; Institute of Pharmacology; Brain Research Institute, Russian Academy of Medical Sciences, Moscow.parochial@mtu-net.ru
authors.forename: G A
authors.initials: GA
authors.lastname: Romanova
authors.forename: T K
authors.initials: TK
authors.lastname: Mirzoev
authors.forename: I V
authors.initials: IV
authors.lastname: Barskov
authors.forename: I V
authors.initials: IV
authors.lastname: Victorov
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaya
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology*; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
chemical_list: D004151:Dipeptides; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly