title: Prenatal diagnosis of agnathia-holoprosencephaly: three-dimensional imaging by helical computed tomography.
abstract: We report a case of agnathia-holoprosencephaly which was prenatally diagnosed based on helical computed tomography (CT) images obtained at 23 weeks of gestation. Ultrasound examination first showed the presence of alobar holoprosencephaly, but the facial structures were not clearly detailed. However, three-dimensional imaging by helical CT precisely demonstrated the most striking feature of agnathia: absence of the mandible. This technique provided us valuable information that contributed to the in utero diagnosis. In utero helical CT is a useful examination tool for the diagnosis of osteogenic abnormalities.
authors.affiliation: Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, N15 W7, Kita-Ku, Sapporo, Japan. ebiyas@med.hokudai.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ebina
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: E H
authors.initials: EH
authors.lastname: Kato
authors.forename: F
authors.initials: F
authors.lastname: Tanuma
authors.forename: S
authors.initials: S
authors.lastname: Shimada
authors.forename: K
authors.initials: K
authors.lastname: Cho
authors.forename: S
authors.initials: S
authors.lastname: Fujimoto
mesh_terms: D000328:Adult; D005260:Female; D016142:Holoprosencephaly / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D007569:Jaw Abnormalities / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D014054:Tomography / Q000379:methods*; D014057:Tomography, X-Ray Computed; D016216:Ultrasonography, Prenatal