title: Conformational changes during kinesin motility.
abstract: Nucleotide-dependent movements of the head and neck of kinesin have been visualized by cryoelectron microscopy and have been inferred from single-molecule studies. Key predictions of the hand-over-hand model for dimeric kinesin have been confirmed, and a novel processivity mechanism for the one-headed, kinesin-related motor KIF1A has been discovered.
authors.affiliation: Department of Physiology & Biophysics, University of Washington, Box 357290, Seattle, Washington 98195-2790, USA. schief@u.washington.edu
authors.forename: W R
authors.initials: WR
authors.lastname: Schief
authors.forename: J
authors.initials: J
authors.lastname: Howard
mesh_terms: D000818:Animals; D016547:Kinesins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D020409:Molecular Motor Proteins; D016547:Kinesins