Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male factor indications for in vitro fertilization: a prospective randomized study.
OBJECTIVE
To compare the fertilization rate and formation of good-quality embryos with conventional IVF and ICSI in patients with non-male factor infertility.


METHODS
Prospective controlled study.


METHODS
Infertility clinic.


METHODS
Thirty-five patients with non-male factor infertility.


METHODS
Retrieved sibling oocytes were randomly assigned to conventional IVF or ICSI. Of sibling oocytes assigned to ICSI, only metaphase II oocytes were injected with sperm.


METHODS
Fertilization rate and formation of good-quality embryos per retrieved oocyte.


RESULTS
Per retrieved oocyte, ICSI resulted in better fertilization rate compared with conventional IVF (71.3% [134 of 188] vs. 57.2% [107 of 187]). Per retrieved oocyte, ICSI also resulted in better formation of good-quality embryos at 48 hours after retrieval compared with conventional IVF (64.4% [121 of 188] vs. 47.1% [88 of 187]).


CONCLUSIONS
In IVF patients with non-male factor infertility, subjecting some sibling oocytes to ICSI increased the fertilization rate and formation of good-quality embryos per retrieved oocyte. It also avoided the problem of total fertilization failure in almost all cases.
Khamsi
F
F
Toronto Fertility Sterility Institute, 66 Avenue Road, Toronto, Ontario, Canada, M5R 3N8. tfsi@aaa-tfsi.cim
Yavas
Y
Y
Roberge
S
S
Wong
J C
JC
Lacanna
I C
IC
Endman
M
M
D000328:Adult; D046508:Culture Techniques; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic