title: MR diffusion imaging and 1H spectroscopy in a child with medulloblastoma. A case report.
abstract: We report on a child with a metastasising medulloblastoma which was assessed by MR diffusion imaging and 1H MR spectroscopy (MRS). Reduced mean apparent diffusion coefficients and a high amount of taurine could be demonstrated. This is the first reported case of high taurine in medulloblastoma in vivo and confirms earlier in vitro findings. It is suggested that the changes on diffusion imaging, possibly reflecting the small-cell histology of the tumour and high taurine in MRS, are indicative of medulloblastoma.
authors.affiliation: NMR Study Group, Max-Planck-Institute of Psychiatry, Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Wilke
authors.forename: A
authors.initials: A
authors.lastname: Eidenschink
authors.forename: S
authors.initials: S
authors.lastname: Müller-Weihrich
authors.forename: D P
authors.initials: DP
authors.lastname: Auer
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D002528:Cerebellar Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008527:Medulloblastoma / Q000737:chemistry / Q000175:diagnosis*; D013654:Taurine / Q000378:metabolism
chemical_list: D013654:Taurine; D001224:Aspartic Acid; C000179:N-acetylaspartate