Dogger Bank Itch revisited: isolation of (2-hydroxyethyl) dimethylsulfoxonium chloride as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis.
(2-Hydroxyethyl) dimethylsulfoxonium chloride (1), the well-known causative agent of Dogger Bank Itch, has been isolated as a cytotoxic constituent from the marine sponge Theonella aff. mirabilis. The structure of 1 was determined by spectral and X-ray crystallographic analyses.
Warabi
K
K
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, 113-8657, Tokyo, Japan.
Nakao
Y
Y
Matsunaga
S
S
Fukuyama
T
T
Kan
T
T
Yokoshima
S
S
Fusetani
N
N
D000818:Animals; D002712:Chlorides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000737:chemistry; D003877:Dermatitis, Contact / Q000209:etiology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008956:Models, Chemical; D008958:Models, Molecular; D011161:Porifera / Q000737:chemistry*; D013452:Sulfonium Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D002712:Chlorides; D003603:Cytotoxins; D013452:Sulfonium Compounds; C033899:2-hydroxyethyl-dimethylsulfoxonium