title: DNA mismatch repair: the hands of a genome guardian.
abstract: DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.
authors.affiliation: Department of Molecular Biology and Skaggs Institute for Chemical Biology,  La Jolla, California, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Hopfner
authors.forename: J A
authors.initials: JA
authors.lastname: Tainer
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020137:Base Pair Mismatch / Q000235:genetics*; D003198:Computer Simulation; D004260:DNA Repair / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D016680:Genome, Bacterial; D008958:Models, Molecular; D051719:MutS DNA Mismatch-Binding Protein
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D000251:Adenosine Triphosphatases; D051719:MutS DNA Mismatch-Binding Protein; C497175:MutS protein, E coli