Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease.
Our previous studies have shown that a minor isoform of acetylcholinesterase (AChE) is increased in the cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients. In the present study, the glycosylation of butyrycholinesterase (BuChE) was found to be altered in AD CSF. By combining an analysis of CSF AChE and BuChE glycosylation, it is possible to identify cases of AD with more than 90% sensitivity and specificity.
Sáez-Valero
J
J
Laboratory of Molecular Neurobiology, Department of Pathology, University of Melbourne, 3010, Victoria, Australia.
Small
D H
DH
D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000201:enzymology*; D002091:Butyrylcholinesterase / Q000134:cerebrospinal fluid*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D007527:Isoenzymes / Q000134:cerebrospinal fluid
D020746:Calcium Channels, L-Type; D007527:Isoenzymes; D002091:Butyrylcholinesterase