title: Calcineurin A and calbindin immunoreactivity in the spinal cord of G93A superoxide dismutase transgenic mice.
abstract: A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneurons are affected by the neurodegenerative process; in contrast, calbindin-positive cells are selectively spared. The findings suggest that calcineurin plays a role as an accessory factor responsible for selective vulnerability in the neurodegenerative process of amyotrophic lateral sclerosis.
authors.affiliation: Department of Neurology, University of Ulm, Oberer Eselsberg 45, D-89081, Ulm, Germany. ursula.knirsch@medizin.uni-ulm.de
authors.forename: U
authors.initials: U
authors.lastname: Knirsch
authors.forename: S
authors.initials: S
authors.lastname: Sturm
authors.forename: A
authors.initials: A
authors.lastname: Reuter
authors.forename: R
authors.initials: R
authors.lastname: Bachus
authors.forename: G
authors.initials: G
authors.lastname: Gosztonyi
authors.forename: H
authors.initials: H
authors.lastname: Voelkel
authors.forename: A C
authors.initials: AC
authors.lastname: Ludolph
mesh_terms: D000818:Animals; D015153:Blotting, Western; D064026:Calbindins; D019703:Calcineurin / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D013482:Superoxide Dismutase; D019703:Calcineurin