Innate immune response of Aedes aegypti.
Insects are able to protect themselves from invasion by pathogens by a rapid and potent arsenal of inducible immune peptides. This fast, extremely effective response is part of the innate immunity exhibited by all insects and many invertebrates, and shows striking similarities with the innate immune response of vertebrates. In Aedes aegypti invasion of the hemocoel by bacteria elicits the production of defensins, cecropins, a peptide active only against Gram-negative bacteria, and several other peptides that we are now characterizing. However, not all insects utilize the same peptides in the same concentrations, which may reflect the pathogens to which they may have been exposed through evolutionary time. These protective measures we see in mosquitoes are the current state of the evolution of a rapid immune response that has contributed to the success of insects in inhabiting essentially every niche on earth. The molecules involved in the response of Aedes aegypti to pathogens, and the potential role of these peptides against eukaryotic parasites ingested and transmitted by mosquitoes are discussed.
Lowenberger
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Animal Health and Biomedical Sciences, University of Wisconsin-Madison, 1656 Linden Drive, , Madison, WI 53706, USA. cal@ahabs.wisc.edu
D000330:Aedes / Q000276:immunology* / Q000469:parasitology; D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D023082:Defensins / Q000302:isolation & purification; D019476:Insect Proteins / Q000302:isolation & purification* / Q000494:pharmacology; D008969:Molecular Sequence Data; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology; D014168:Transferrin / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D023082:Defensins; D019476:Insect Proteins; D010455:Peptides; D014168:Transferrin