title: Immunotoxic effects during acute ethylene glycol poisoning.
abstract: Experiments on outbred and inbred male CBA mice showed that acute poisoning with ethylene glycol (0.8 LD50) increased mortality from infections, decreased the number of spleen colony-forming units, inhibited antibody formation (mainly to thymus-dependent antigens, and suppressed natural and antibody-dependent cytotoxicity and delayed-type hypersensitivity. Ethylene glycol in concentrations of 10 and 100 mM in vitro inhibited the formation of antibody-producing cells by acting on T and B lymphocytes.
authors.affiliation: Department of Toxicology, Saratov Medical University.
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskii
authors.forename: V G
authors.initials: VG
authors.lastname: Germanchuk
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000276:immunology*; D003114:Colony-Forming Units Assay; D004342:Drug Hypersensitivity / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology; D019855:Ethylene Glycol / Q000506:poisoning*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010538:Peritonitis / Q000276:immunology / Q000382:microbiology; D011041:Poisoning / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D019855:Ethylene Glycol