The fetal lung. 2: Pulmonary hypoplasia.
This review describes the pathogenesis of pulmonary hypoplasia and highlights its clinical, radiological and pathologic features, with emphasis on oligohydramnios-related pulmonary hypoplasia. Since pulmonary hypoplasia may lead to severe respiratory distress immediately after birth and even to neonatal death, an accurate and patient-friendly prenatal test for early detection and distinction between lethal and non-lethal pulmonary hypoplasia is still highly desirable. An extended overview of the proposed methods for the prenatal prediction of pulmonary hypoplasia is presented.
Laudy
J A
JA
Department of Obstetrics and Gynecology, University Hospital Rotterdam, The Netherlands.
Wladimiroff
J W
JW
D005260:Female; D006801:Humans; D015994:Incidence; D008168:Lung / Q000002:abnormalities* / Q000000981:diagnostic imaging* / Q000196:embryology; D008176:Lung Volume Measurements; D011247:Pregnancy; D011379:Prognosis; D011652:Pulmonary Circulation; D012307:Risk Factors; D015996:Survival Rate; D018615:Ultrasonography, Doppler, Color / Q000379:methods; D016216:Ultrasonography, Prenatal / Q000379:methods*