title: Immunogenicity of pneumococcal vaccine in heart transplant recipients.
abstract: To assess the immunogenicity of pneumococcal vaccine in recipients of heart transplants, we immunized 35 long-term transplantation survivors with pneumococcal vaccine and measured the pre- and postvaccination IgG antibody titers to 5 representative vaccine capsular polysaccharides. Responses of heart transplant recipients to pneumococcal vaccine antigens were generally suppressed.
authors.affiliation: Department of Medicine and MCP Hahnemann School of Medicine, Philadelphia, PA, USA. blumbere@mail.med.upenn.edu
authors.forename: E A
authors.initials: EA
authors.lastname: Blumberg
authors.forename: S C
authors.initials: SC
authors.lastname: Brozena
authors.forename: P
authors.initials: P
authors.lastname: Stutman
authors.forename: D
authors.initials: D
authors.lastname: Wood
authors.forename: H M
authors.initials: HM
authors.lastname: Phan
authors.forename: D M
authors.initials: DM
authors.lastname: Musher
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D000917:Antibody Formation; D016667:Bacterial Capsules / Q000276:immunology; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D007110:Immunity, Active; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D013296:Streptococcus pneumoniae / Q000276:immunology; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines