Serum carotenoids, alpha-tocopherol and mortality risk in a prospective study among Dutch elderly.
BACKGROUND
Although beta-carotene has shown inverse associations with chronic diseases involving free radical damage in observational epidemiological studies less attention has been paid to five other major carotenoids also showing antioxidant activity in vitro.


METHODS
We studied the associations between 7.2-year mortality and serum levels of six carotenoids, and alpha-tocopherol, measured in stored serum, sampled in 1991/1992 during a health survey among 638 independently living elderly subjects aged 65-85 years. Proportional hazards regression was used to estimate hazard ratios of all-cause mortality for the lowest tertiles of serum vitamins with the highest tertiles, adjusting for possible confounding effects.


RESULTS
During a follow-up period of 7.2 years 171 elderly died. The adjusted hazard ratios for all-cause mortality for the lowest tertiles of vitamins compared with the highest tertiles were between 1.02 and 1.73. The strongest increase in mortality risk was seen for beta-cryptoxanthin (1.52, 95% CI : 1.00, 2.32), lutein (1.56, 95% CI : 1.05, 2.31) and zeaxanthin (1.32, 95% CI : 0.89, 1.97) and their sum (oxygenated carotenoids: 1.73, 95% CI : 1.12, 2.67). Tests for trend were significant (P < 0.05) for all-cause mortality risk and serum levels of total carotenoids, oxygenated carotenoids and beta-cryptoxanthin.


CONCLUSIONS
Our findings suggest that serum levels of individual carotenoids, particularly the oxygenated species are inversely associated with all-cause mortality and should be considered as candidates for further investigations.
De Waart
F G
FG
The Division of Human Nutrition and Epidemiology, Wageningen University and Research Center, Wageningen, The Netherlands. frouwkje.hans@consunet.nl
Schouten
E G
EG
Stalenhoef
A F
AF
Kok
F J
FJ
D000368:Aged; D000369:Aged, 80 and over; D016588:Anticarcinogenic Agents / Q000097:blood; D002338:Carotenoids / Q000097:blood*; D065366:Cryptoxanthins; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D009026:Mortality; D009426:Netherlands; D016016:Proportional Hazards Models; D011446:Prospective Studies; D014810:Vitamin E / Q000097:blood*; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives* / Q000097:blood
D016588:Anticarcinogenic Agents; D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids