Nodularin-Har: a new nodularin from Nodularia.
A cyanobacterial hepatotoxin, nodularin-Har, having a homoarginine instead of an arginine in nodularin, was isolated from Nodularia PCC7804. The structure was elucidated as 1 on the basis of 2D NMR and FABMS. The LD(50) (mouse ip) value of 1 was 70 microg/kg.
Saito
K
K
School of Marine Science and Technology, Tokai University, 3-20-1 Orido, Shimizu, Shizuoka 424-8610, Japan.
Konno
A
A
Ishii
H
H
Saito
H
H
Nishida
F
F
Abe
T
T
Chen
C
C
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D000087522:Cyanobacteria Toxins; D008401:Gas Chromatography-Mass Spectrometry; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000633:toxicity; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000087522:Cyanobacteria Toxins; D010456:Peptides, Cyclic; C428197:nodularin-Har