Activation of neostriatal dopaminergic system in rats prevents toxic effects of picrotoxin administered into globus pallidus.
Multiple bilateral microinjections of 5 microg picrotoxin (antagonist of chloride channels coupled with GABAA receptors) into the globus pallidus induced lethal seizures in some rats and impaired conditioned avoidance responses in survivors. Administration of 15 microg amphetamine into the rostral neostriatum prevented picrotoxin-induced lethal seizures and reduced its negative effects on active avoidance behavior. Activation of the neostriatal dopaminergic system in animals receiving no intrapallidal picrotoxin promoted recovery of conditioned responses after implantation procedure.
Yakimovskii
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Department of Normal Physiology, I. P. Pavlov State Medical Academy, St. Petersburg. martyn@spmu.rssi.ru
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D058787:GABA-A Receptor Antagonists; D005917:Globus Pallidus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000502:physiology*; D010852:Picrotoxin / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000502:physiology; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000661:Amphetamine; D004298:Dopamine; D058787:GABA-A Receptor Antagonists; D010852:Picrotoxin; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid