title: [Clinical analysis of 15 cases of jaundice type intrahepatic cholestasis in pregnancy (ICP)].
abstract: We have analysed 15 cases of jaundice type ICP (JICP). The result showed that the incidence of JICP was 12.7 percent in ICP patients while the rectified perinatal baby mortality was 12.7 percent in ICP patients while the rectified perinatal baby mortality was 26.7%. The main clinical features were early and severe jaundice. The average levels of the total bilirubin and direct bilirubin were 123.32 +/- 86.9 mumol.L-1 and 66.77 +/- 49.7 mumol.L-1, respectively. They were significantly higher than those of the common types (P < 0.01). The level of blood biliary acid increased obviously. The morbidity of JICP in the perinatal babies and postpartal hemorrhage in the mothers were increased. It is considered that: 1. The routine DIC examination should be taken and massive therapy of vitamin K should be given to these patients. 2. The proper delivery time is the 36-37th week gestation. 3. We should choose in principle the vaginal delivery in these patients. In the severe patients the elective caesarean section is the first choice and operative vaginal delivery is undesirable.
authors.affiliation: Department of Obstetrics and Gynecology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
authors.forename: Z
authors.initials: Z
authors.lastname: Wu
mesh_terms: D000328:Adult; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis*; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D013997:Time Factors