title: Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract.
abstract: Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and Crohn's disease (CD).
authors.affiliation: Laboratoire Universitaire de Transfert en Immunologie, Universités Paris V, Paris VI/Laboratorie Pierre Fabre, France. frank.pages@cochin.univ-paris5.fr
authors.forename: F
authors.initials: F
authors.lastname: Pages
authors.forename: A
authors.initials: A
authors.lastname: Berger
authors.forename: S
authors.initials: S
authors.lastname: Lebel-Binay
authors.forename: F
authors.initials: F
authors.lastname: Zinzindohoue
authors.forename: C
authors.initials: C
authors.lastname: Danel
authors.forename: B
authors.initials: B
authors.lastname: Piqueras
authors.forename: O
authors.initials: O
authors.lastname: Carriere
authors.forename: N
authors.initials: N
authors.lastname: Thiounn
authors.forename: P H
authors.initials: PH
authors.lastname: Cugnenc
authors.forename: W H
authors.initials: WH
authors.lastname: Fridman
mesh_terms: D003110:Colonic Neoplasms / Q000276:immunology* / Q000473:pathology; D003424:Crohn Disease / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology; D020382:Interleukin-18 / Q000096:biosynthesis* / Q000737:chemistry / Q000502:physiology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000378:metabolism
chemical_list: D020382:Interleukin-18