Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8.
Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted into the inflamed synovium and accumulate there has not been completely delineated. The results of this study show that rheumatoid arthritis synovial stromal cells produce the chemokines monocyte chemotactic protein-1 and IL-8, and these have the capacity to attract peripheral monocytes. These results suggest that one of the mechanisms by which macrophages accumulate in the inflamed synovium is by responding to the chemokines produced locally.
Hayashida
K
K
University of Texas, Southwestern Medical Center, Dallas, Texas, USA. lipskyp@mail.nih.gov
Nanki
T
T
Girschick
H
H
Yavuz
S
S
Ochi
T
T
Lipsky
P E
PE
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000473:pathology*; D002460:Cell Line; D002465:Cell Movement; D002474:Cell-Free System; D018932:Chemokine CCL2 / Q000096:biosynthesis* / Q000502:physiology; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000502:physiology; D009000:Monocytes / Q000378:metabolism / Q000473:pathology*; D012333:RNA, Messenger / Q000096:biosynthesis; D019707:Receptors, Chemokine / Q000096:biosynthesis; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D018932:Chemokine CCL2; D016209:Interleukin-8; D012333:RNA, Messenger; D019707:Receptors, Chemokine; D014409:Tumor Necrosis Factor-alpha