title: A centuries-long epidemic of scrapie in British sheep?
abstract: The apparent persistence of scrapie in British sheep for more than 250 years is difficult to explain. Susceptibility to scrapie is associated with particular alleles at a single locus, the PrP gene. As the only known effect of these alleles is to confer susceptibility to a fatal disease, natural selection is expected to reduce their frequency, as has been observed in practice during scrapie outbreaks in single sheep flocks. Susceptibility alleles, and hence scrapie itself, are therefore expected to become rare, yet the disease remains widespread. We suggest that the paradox of scrapie's persistence can be explained by the exceptionally long time-scales inherent in the epidemiology of the disease. It is proposed that scrapie should be regarded as epidemic in British sheep but, unlike more familiar epidemics, which have time-scales of months or years, the scrapie epidemic has a time-scale of centuries. This interpretation implies that scrapie should eventually disappear from the sheep population.
authors.affiliation: Centre for Tropical Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, EH25 9RG, Midlothian, UK. mark.woolhouse@ed.ac.uk
authors.forename: M E
authors.initials: ME
authors.lastname: Woolhouse
authors.forename: P
authors.initials: P
authors.lastname: Coen
authors.forename: L
authors.initials: L
authors.lastname: Matthews
authors.forename: J D
authors.initials: JD
authors.lastname: Foster
authors.forename: J M
authors.initials: JM
authors.lastname: Elsen
authors.forename: R M
authors.initials: RM
authors.lastname: Lewis
authors.forename: D T
authors.initials: DT
authors.lastname: Haydon
authors.forename: N
authors.initials: N
authors.lastname: Hunter
mesh_terms: D000818:Animals; D004196:Disease Outbreaks / Q000266:history / Q000662:veterinary*; D020022:Genetic Predisposition to Disease; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D012608:Scrapie / Q000453:epidemiology / Q000235:genetics / Q000266:history*; D012756:Sheep; D006113:United Kingdom / Q000453:epidemiology