Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression.
Cell proliferation is dependent upon the activation of receptor tyrosine kinases and integrins by soluble growth factors and extracellular matrix proteins, respectively. It is now apparent that concerted, rather than individual, signaling by these receptors is the critical feature responsible for cell-cycle progression through G1 phase. ERK (extracellular signal-regulated kinase), Rho GTPases and G1-phase cyclin-dependent kinases are all regulated jointly by growth-factor receptors and integrins. Recent studies have begun to reveal how this regulated signaling in the cytoplasm is linked to activation of the G1-phase cyclin-dependent kinases in the nucleus.
Assoian
R K
RK
Department Of Pharmacology, University of Pennsylvania School of Medicine, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104, USA.rka@pharm.med.upenn.edu
Schwartz
M A
MA
D000818:Animals; D002448:Cell Adhesion; D019938:Cyclin D1 / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D005109:Extracellular Matrix; D016193:G1 Phase / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000502:physiology
D016023:Integrins; D019938:Cyclin D1; D020794:Receptor Protein-Tyrosine Kinases; D018844:Cyclin-Dependent Kinases; D020928:Mitogen-Activated Protein Kinases; D020741:rho GTP-Binding Proteins