title: The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens.
abstract: The ability to induce a protective immunity against Jembrana disease, an acute lentivirus disease of Bali cattle (Bos javanicus) present in Indonesia, was investigated. A protective immune response was induced in cattle by vaccination with virus-containing plasma and spleen tissue derived from acutely affected cattle. The virus was inactivated with Triton X-100 and emulsified in either incomplete Freund's adjuvant or a mineral oil adjuvant (MOA). The vaccination procedure suppressed the duration and severity of the disease but did not completely prevent the development of disease in animals challenged with 100 infectious doses of virus.
authors.affiliation: Bali Cattle Disease Investigation Unit, BPPH, PO Box 3322, Denpasar, Bali, Indonesia.
authors.forename: N
authors.initials: N
authors.lastname: Hartaningsih
authors.forename: D M
authors.initials: DM
authors.lastname: Dharma
authors.forename: S
authors.initials: S
authors.lastname: Soeharsono
authors.forename: G E
authors.initials: GE
authors.lastname: Wilcox
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood / Q000276:immunology*; D015153:Blotting, Western / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005557:Formaldehyde; D005620:Freund's Adjuvant / Q000276:immunology / Q000494:pharmacology; D016180:Lentivirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017960:Lentiviruses, Bovine / Q000254:growth & development / Q000276:immunology*; D008899:Mineral Oil / Q000494:pharmacology; D017830:Octoxynol; D013154:Spleen / Q000821:virology; D014611:Vaccination / Q000662:veterinary*; D015164:Vaccines, Inactivated / Q000276:immunology / Q000592:standards; D014765:Viral Vaccines / Q000276:immunology / Q000592:standards
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D005557:Formaldehyde; D008899:Mineral Oil; D017830:Octoxynol; D005620:Freund's Adjuvant