Mechanisms of myelopoiesis stimulation with pantohematogen and granulocyte colony-stimulating factor during cytostatic myelosuppression.
We compared hemopoiesis-stimulating activities of dry pantohematogen and recombinant granulocyte colony-stimulating factor under conditions of cyclophosphamide-induced myelosuppression. These preparations stimulated regeneration of bone marrow granulomonocytopoiesis by various mechanisms.
Gol'dberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.
Dygai
A M
AM
Gur'yantseva
L A
LA
Zhdanov
V V
VV
Pozhen'ko
N S
NS
Simanina
E V
EV
Suslov
N I
NI
Khrichkova
T Y
TY
Udut
E V
EV
Gol'dberg
V E
VE
Matyash
M G
MG
Popova
N O
NO
D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D001685:Biological Factors; D003520:Cyclophosphamide / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects; D019891:Leukopoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009000:Monocytes / Q000187:drug effects; D011994:Recombinant Proteins
D000485:Allergens; D018906:Antineoplastic Agents, Alkylating; D001685:Biological Factors; D011994:Recombinant Proteins; C404022:pantohematogen; D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide