title: Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis.
abstract: Decreased glutamate uptake and a loss of the astrocytic glutamate transporter EAAT2 (GLT-1) have been shown in spinal cord and motor cortex of patients with ALS. Because platelets express the three major glutamate transporter subtypes, including GLT-1, and possess a high-affinity glutamate uptake, the authors investigated glutamate uptake in platelets from patients with ALS and controls. A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS.
authors.affiliation: Department of Neurosciences and Biomedical Technologies, University of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ferrarese
authors.forename: G
authors.initials: G
authors.lastname: Sala
authors.forename: R
authors.initials: R
authors.lastname: Riva
authors.forename: B
authors.initials: B
authors.lastname: Begni
authors.forename: C
authors.initials: C
authors.lastname: Zoia
authors.forename: L
authors.initials: L
authors.lastname: Tremolizzo
authors.forename: G
authors.initials: G
authors.lastname: Galimberti
authors.forename: A
authors.initials: A
authors.lastname: Millul
authors.forename: A
authors.initials: A
authors.lastname: Bastone
authors.forename: T
authors.initials: T
authors.lastname: Mennini
authors.forename: C
authors.initials: C
authors.lastname: Balzarini
authors.forename: L
authors.initials: L
authors.lastname: Frattola
authors.forename: E
authors.initials: E
authors.lastname: Beghi
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D000704:Analysis of Variance; D015415:Biomarkers; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D018698:Glutamic Acid