Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model.
The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr--Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr--Abl upregulation of glucose transport was mediated by phosphatidylinositol-3-kinase. The observation that Bcr--Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.
Bentley
J
J
School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK. Johanne.Bentley@ncl.ac.uk
Walker
I
I
McIntosh
E
E
Whetton
A D
AD
Owen-Lynch
P J
PJ
Baldwin
S A
SA
D001692:Biological Transport; D016923:Cell Death; D002460:Cell Line; D003847:Deoxyglucose / Q000378:metabolism*; D016044:Fusion Proteins, bcr-abl / Q000378:metabolism*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism
D003847:Deoxyglucose; D019869:Phosphatidylinositol 3-Kinases; D016044:Fusion Proteins, bcr-abl