Coexistent cutaneous Aspergillus and cytomegalovirus infection in a liver transplant recipient.
Cutaneous infections are a significant cause of morbidity in solid organ recipients. These infections may be complex with multiple pathogens occurring in the same lesion. We describe the unusual association of cutaneous Aspergillus and cytomegalovirus (CMV) infections in a liver transplant recipient. Cutaneous CMV infection is rare and often indicates severe systemic involvement, whereas Aspergillus is a frequent cause of opportunistic cutaneous fungal infection. Seven weeks after liver transplantation, our patient had hemorrhagic, eroded plaques develop on his arms. The results of routine histology, immunoperoxidase staining for CMV antibody, and fungal culture revealed coexistent cutaneous Aspergillus flavus and CMV infections. The patient was treated with ganciclovir, amphotericin B, and topical terbinafine cream; however, 2 weeks after the development of the cutaneous lesions, the patient died.
Wong
J
J
Department of Dermatology, University of Illinois at Chicago, 60612-7307, USA.
McCracken
G
G
Ronan
S
S
Aronson
I
I
D000935:Antifungal Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D016867:Immunocompromised Host; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications / Q000601:surgery; D017093:Liver Failure / Q000209:etiology / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; D000998:Antiviral Agents