Micronized ethylcellulose used for designing a directly compressed time-controlled disintegration tablet.
Ethylcellulose (EC) of varying particle sizes has been used as an outer coating layer to design a novel dry-coated tablet with time-controlled drug release. This dry-coated tablet, containing a core tablet of sodium diclofenac and an outer coating layer of EC, was prepared by direct compression. The drug release from dry-coated tablet exhibited an initial lag period that was dependent on the particle size of the EC powder, followed by a stage of rapid drug release. The smaller the EC particle size used the longer the lag time obtained, suggesting the particle size of EC powder could modulate the timing of drug release from such a dry-coated tablet. The period of the lag time for sodium diclofenac released from dry-coated tablets was correlated with the penetration distance of the solvent into dry-coated tablet by an in vitro dye penetration study. The densest packing of EC powders appeared on the upper and lower surfaces of dry-coated tablet after compression, resulting in a tight structure yielding a slower penetration of the solvent. Whereas loose packing of EC powders occurred in the middle of the lateral surface of dry-coated tablet, this loosely packed surface readily allowed solvent penetration and that finally caused the splitting of tablet shell into two halves in the dissolution medium. The results suggest that these dry-coated tablets prepared with different particle sizes of EC powder as an outer coating layer might offer a desirable release profile for drug delivery at the predetermined times and/or sites.
Lin
S Y
SY
Biopharmaceutical Laboratory, Department of Medical Research and Education, Veterans General Hospital-Taipei, Taipei, Taiwan, ROC. sylin@vghtpe.gov.tw
Lin
K H
KH
Li
M J
MJ
D002482:Cellulose / Q000008:administration & dosage* / Q000031:analogs & derivatives; D010316:Particle Size; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D013607:Tablets; C013517:ethyl cellulose; D002482:Cellulose