Immunotoxic effects during acute ethylene glycol poisoning.
Experiments on outbred and inbred male CBA mice showed that acute poisoning with ethylene glycol (0.8 LD50) increased mortality from infections, decreased the number of spleen colony-forming units, inhibited antibody formation (mainly to thymus-dependent antigens, and suppressed natural and antibody-dependent cytotoxicity and delayed-type hypersensitivity. Ethylene glycol in concentrations of 10 and 100 mM in vitro inhibited the formation of antibody-producing cells by acting on T and B lymphocytes.
Zabrodskii
P F
PF
Department of Toxicology, Saratov Medical University.
Germanchuk
V G
VG
D000818:Animals; D021461:Animals, Outbred Strains; D000917:Antibody Formation / Q000187:drug effects*; D001402:B-Lymphocytes / Q000276:immunology*; D003114:Colony-Forming Units Assay; D004342:Drug Hypersensitivity / Q000276:immunology; D004927:Escherichia coli Infections / Q000276:immunology; D019855:Ethylene Glycol / Q000506:poisoning*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010538:Peritonitis / Q000276:immunology / Q000382:microbiology; D011041:Poisoning / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D019855:Ethylene Glycol