title: Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy.
abstract: The relationship between the levels of serum cystatin C and the prognostic stages of IgA nephropathy was determined in a multicenter trial in Japan. The levels of serum cystatin C in patients with IgA nephropathy were measured using the Dade Behring N Latex Cystain C assay. In 1995, the Joint Committee of the Special Study Group on Progressive Glomerular Diseases, Ministry of Health and Welfare of Japan, and the Japanese Society of Nephropathy reported four prognostic stages. These are: good prognosis group (Group I), relatively good prognosis group (Group II), relatively poor prognosis group (Group III), and poor prognosis group (Group IV), for this disease. Three-hundred and six patients with IgA nephropathy and other glomerular diseases were examined. There were no significant changes in the levels of serum creatinine (Cr) or creatinine clearance (CCr) between Group I and Group II. The mean levels of serum cystatin C in Group II were significantly higher than those in Group I (P < 0.05). The mean levels of serum cystatin C in Group III or IV were significantly higher than those in Group I (P < 0.001, P < 0.005, respectively). These suggest that the measurement of serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy.
authors.affiliation: Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Tomino
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Gohda
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Horikoshi
authors.forename: H
authors.initials: H
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: N
authors.initials: N
authors.lastname: Yorioka
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: Y
authors.initials: Y
authors.lastname: Yasumoto
authors.forename: H
authors.initials: H
authors.lastname: Kida
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Endoh
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Saito
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005920:Glomerular Mesangium / Q000648:ultrastructure; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011379:Prognosis; D012016:Reference Values
chemical_list: C525030:CST3 protein, human; D003176:Complement C3; D055316:Cystatin C; D015891:Cystatins; D007070:Immunoglobulin A; D003404:Creatinine