title: Abdominal decompression plays a major role in early postparacentesis haemodynamic changes in cirrhotic patients with tense ascites.
abstract: BACKGROUND
  Some cirrhotic patients with tense ascites who undergo paracentesis develop a circulatory dysfunction syndrome, manifested by an increase in plasma renin activity. Recently, a significant inverse correlation between postparacentesis changes in plasma renin activity and systemic vascular resistance has been demonstrated in these patients, suggesting that peripheral arterial vasodilatation could be responsible for this circulatory dysfunction, but the mechanisms by which tense ascites removal induces such changes are unknown
  
  
  OBJECTIVE
  To investigate the role of a decrease in intra-abdominal pressure (IAP) in the development of early postparacentesis haemodynamic changes
  
  
  METHODS
  Eleven cirrhotic patients with tense ascites received a large volume paracentesis. A specially designed pneumatic girdle was used to compress the abdomen to avoid a decrease in IAP during ascites removal. Haemodynamic studies were performed before paracentesis, one hour after ascites flow stopped, and 30 minutes after pneumatic girdle deflation
  
  
  RESULTS
  When IAP was maintained at its original level, no haemodynamic changes were observed, despite large volume paracentesis. However, a significant decrease in systemic vascular resistance was seen immediately after pneumatic girdle deflation
  
  
  CONCLUSIONS
  Early haemodynamic changes after paracentesis are avoided if IAP is maintained at its original level. The abrupt decrease in IAP could be the trigger for the development of the initial haemodynamic changes that eventually produce postparacentesis circulatory dysfunction.
authors.affiliation: Hepatology Section, Unit of Investigation, Hospital General Universitario de Gran Canaria, Doctor Negrín, Universidad de Las Palmas de Gran Canaria, Spain. med004083@nacom.es
authors.forename: J
authors.initials: J
authors.lastname: Cabrera
authors.forename: L
authors.initials: L
authors.lastname: Falcón
authors.forename: E
authors.initials: E
authors.lastname: Gorriz
authors.forename: M D
authors.initials: MD
authors.lastname: Pardo
authors.forename: R
authors.initials: R
authors.lastname: Granados
authors.forename: A
authors.initials: A
authors.lastname: Quinones
authors.forename: M
authors.initials: M
authors.lastname: Maynar
mesh_terms: D000005:Abdomen / Q000503:physiopathology; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001201:Ascites / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D019299:Decompression, Surgical / Q000009:adverse effects* / Q000379:methods; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016011:Normal Distribution; D019152:Paracentesis / Q000009:adverse effects* / Q000379:methods; D011312:Pressure; D014655:Vascular Resistance / Q000502:physiology