Identification and characterisation of a novel gene, TSGA10, expressed in testis.
We describe the isolation of a novel gene, TSGA10, by differential mRNA display which is expressed solely in adult human testis. It seems likely that the gene is expressed during spermatogenesis possibly in spermatocytes. The gene is composed of 19 exons extending over more than 80 kb. The complete cDNA contains an open reading frame of 2094 nucleotides, which appears to encode a novel protein. It has been mapped by polymerase chain reaction on a panel of somatic cell hybrids and by fluorescence in situ hybridization to chromosome 2q11.2.
Modarressi
M H
MH
Department of Biology, University College London, Wolfson House, 4, Stephenson Way, NW1 2HE, London, UK.
Cameron
J
J
Taylor
K E
KE
Wolfe
J
J
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D017398:Alternative Splicing; D001483:Base Sequence; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D003598:Cytoskeletal Proteins; D005091:Exons; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009845:Oligospermia / Q000235:genetics; D009928:Organ Specificity; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D013091:Spermatogenesis / Q000235:genetics; D013737:Testis / Q000502:physiology*
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D003598:Cytoskeletal Proteins; D011506:Proteins; C429756:TSGA10 protein, human