Effects of beta-carotene and aspartame on clustogenic activity of cyclophosphamide and dioxidine in mice.
Antimutagenic effects of combination of aspartame (0.4 and 4 mg/kg) and beta-carotene (0.15-15 mg/kg) were studied by estimation of chromosome aberrations in bone marrow cells of C57Bl/6 mice. Single and 5-day treatment with this combination decreased the clastogenic effects of dioxidine and cyclophosphamide and produced a more potent and universal antimutagenic effect than its constituents.
Belogolovskaya
E G
EG
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Oreshchenko
A V
AV
Durnev
A D
AD
Seredenin
S B
SB
Litvinova
E V
EV
Zubtsov
Y N
YN
D000818:Animals; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001218:Aspartame / Q000008:administration & dosage / Q000494:pharmacology*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009153:Mutagens / Q000494:pharmacology / Q000633:toxicity*; D011810:Quinoxalines / Q000008:administration & dosage / Q000633:toxicity*; D019207:beta Carotene / Q000008:administration & dosage / Q000494:pharmacology*
D016587:Antimutagenic Agents; D009153:Mutagens; D011810:Quinoxalines; D019207:beta Carotene; C001077:dioxidine; D003520:Cyclophosphamide; D001218:Aspartame