title: Cerivastatin modulates antiatherogenic properties of high-density lipoproteins in patients with coronary heart disease and hyperlipidemia.
abstract: The effects of cerivastatin on antiatherogenic properties of high-density lipoproteins were studied in patients with coronary heart disease and hyperlipidemia. Apart from hypolipidemic effects, cerivastatin changed the phospholipid composition of high-density lipoproteins and improved their cholesterol-acceptor properties. This effect was most pronounced in the serum from patients with low content of high-density lipoprotein cholesterol. These data indicate that cerivastatin modulates antiatherogenic properties of high-density lipoproteins.
authors.affiliation: Department of Metabolic Disorders, Research Center of Preventive Medicine, Russian Ministry of Health, Moscow.
authors.forename: I N
authors.initials: IN
authors.lastname: Ozerova
authors.forename: D M
authors.initials: DM
authors.lastname: Jeevan
authors.forename: A P
authors.initials: AP
authors.lastname: Serdyuk
authors.forename: I V
authors.initials: IV
authors.lastname: Paramonova
authors.forename: N M
authors.initials: NM
authors.lastname: Akhmedzhanov
authors.forename: V A
authors.initials: VA
authors.lastname: Metel'skaya
authors.forename: N V
authors.initials: NV
authors.lastname: Perova
mesh_terms: D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D004311:Double-Blind Method; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000188:drug therapy; D008075:Lipoproteins, HDL / Q000097:blood / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood / Q000737:chemistry; D011725:Pyridines / Q000494:pharmacology*
chemical_list: D008075:Lipoproteins, HDL; D010743:Phospholipids; D011725:Pyridines; D002784:Cholesterol; C086276:cerivastatin