Polymeric Ig receptor: defender of the fort or Trojan horse?
The polymeric immunoglobulin receptor (pIgR) is important in host defense, transporting antibodies across mucosal epithelial cells. Recent work has shown that, using a protein that binds directly to the pIgR, Streptococcus pneumoniae can co-opt the transcytosis machinery and gain entry into airway epithelial cells.
Kaetzel
C S
CS
Department of Pathology, University of Kentucky, Lexington, Kentucky 40536, USA.
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001422:Bacterial Adhesion / Q000502:physiology; D019143:Evolution, Molecular; D006801:Humans; D019056:Receptors, Polymeric Immunoglobulin / Q000502:physiology*; D013296:Streptococcus pneumoniae / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D019056:Receptors, Polymeric Immunoglobulin