Cerebroprotective effects of diquertin and ascorbic acid.
Electron microscopy and electrophysiological studies revealed pronounced structural and functional changes in the brain cortex in rats with experimental cerebral ischemia. Repeated administration of diquertin and ascorbic acid significantly attenuates ischemic damage induced by circulatory disturbances.
Plotnikov
M B
MB
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Science, Russia. oal@pharm.tsu.ru
Logvinov
S V
SV
Pugachenko
N V
NV
Maslov
M Y
MY
Aliev
O I
OI
Tyukavina
N A
NA
Suslov
N I
NI
Potapov
A V
AV
D000513:Alpha Rhythm / Q000187:drug effects; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001611:Beta Rhythm / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D002540:Cerebral Cortex / Q000293:injuries / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology; D020011:Protective Agents / Q000494:pharmacology; D011794:Quercetin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013826:Theta Rhythm / Q000187:drug effects
D000975:Antioxidants; D020011:Protective Agents; D011794:Quercetin; D001205:Ascorbic Acid