title: Adrafinil: effects on behavior and cognition in aged canines.
abstract: 1. Adrafmil is a novel vigilance promoting agent developed in France by Louis Lafon Laboratories. 2. Adrafinil causes increased locomotion without producing stereotypical activity in canines tested in an open field. 3. The effectiveness of a single treatment is long-lasting, and the effectiveness persists over repeated treatments. 4. Acquisition of a size discrimination problem is enhanced by adrafinil. This may be linked to performance motivation. 5. Adrafinil causes a long-lasting increase in high frequency electroencephalographic activity recorded from cortical electrodes. 6. These results indicate that adrafinil is novel behavioral stimulant with cognitive enhancing potential. The underlying mechanisms of action are still unknown.
authors.affiliation: Institute of Medical Science, University of Toronto, Canada.
authors.forename: C T
authors.initials: CT
authors.lastname: Siwak
authors.forename: H
authors.initials: H
authors.lastname: Callahan
authors.forename: N W
authors.initials: NW
authors.lastname: Milgram
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology; D003071:Cognition / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects*; D004285:Dogs; D004569:Electroencephalography; D005260:Female; D006877:Hydroxamic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008124:Locomotion / Q000187:drug effects*; D008297:Male
chemical_list: D000697:Central Nervous System Stimulants; D006877:Hydroxamic Acids; C022116:adrafinil