title: Arabidopsis thaliana mutants disrupted in lipid mobilization.
abstract: To isolate mutants in the process of lipid mobilization during post-germinative growth we employed a screen using the pro-herbicide 2,4-dichlorophenoxybutyric acid (2,4-DB). The phenotypes of a number of 2,4-DB-resistant mutants are compared with previously characterized mutants disrupted in beta-oxidation or the glyoxylate cycle. We conclude that the strength of 2,4-DB resistance and the ability of the seedlings to grow in the absence of exogenous sugar are inversely correlated. Sugar dependence of 2,4-DB-resistant seedlings is a consequence of impaired storage-lipid mobilization.
authors.affiliation: Centre for Novel Agricultural Products, Department of Biology, University of York, CSL, Sand Hutton, York YO41 1LZ, UK.
authors.forename: P R
authors.initials: PR
authors.lastname: Lange
authors.forename: I
authors.initials: I
authors.lastname: Graham
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism*; D001711:Biotransformation; D003433:Crosses, Genetic; D003624:Darkness; D004351:Drug Resistance / Q000235:genetics; D005227:Fatty Acids / Q000378:metabolism; D006540:Herbicides / Q000494:pharmacology; D050356:Lipid Metabolism; D008053:Lipid Mobilization / Q000187:drug effects / Q000502:physiology*; D008956:Models, Chemical; D010641:Phenotype; D013395:Sucrose / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid; D013395:Sucrose; C004764:4-(2,4-dichlorophenoxy)butyric acid