Development of anorexia in concanavalin A-induced hepatitis in mice.
Anorexia that develops in chronic hepatitis is associated with cytokine expression in the brain. Treatment of mice with concanavalin A (12.5 mg/kg, i.v.) elevated the plasma alanine aminotransferase activity at 8.5 h after treatment. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta mRNA expression was induced at 6 and 24 h after concanavalin A treatment in both the liver and brain. Treatment of mice with concanavalin A reduced the body weight at 24 h after treatment and this decreased body weight was accompanied by a decreased food intake. Glycyrrhizin (200 mg/kg, i.p.) inhibited the concanavalin A-induced elevation of plasma alanine aminotransferase activity, however, it did not inhibit the concanavalin A-induced decreased body weight. The present results indicate that treatment of mice with concanavalin A caused the development of anorexia and that this anorexia might develop independently of the induction of hepatitis.
Okamoto
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T
Research Laboratories, Nippon Chemiphar Co., Ltd, 1-22 Hikokawato, Misato, Saitama 341-0005, Japan.
Okabe
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S
D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000818:Animals; D000855:Anorexia / Q000209:etiology*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000209:etiology; D003208:Concanavalin A / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects; D005260:Female; D019695:Glycyrrhizic Acid / Q000494:pharmacology; D006520:Hepatitis, Animal / Q000139:chemically induced / Q000150:complications*; D007375:Interleukin-1 / Q000235:genetics; D008099:Liver / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D007375:Interleukin-1; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D003208:Concanavalin A; D019695:Glycyrrhizic Acid; D000410:Alanine Transaminase