3-[123I]iodo-alpha-methyl-L-tyrosine transport and 4F2 antigen expression in human glioma cells.
3[(123)I]iodo-alpha-methyl-L-tyrosine is a tracer of amino acid transport in brain tumors using single-photon emission-computed tomography and predominantly transported by amino acid transport system L. The 4F2 antigen has been identified to be linked to system L-like transport and is assumed to be a part of the transporter protein. We demonstrated that system L-mediated transport of IMT and 4F2 antigen expression are dependent on proliferation rate of human glioma cells and significantly correlated with each other.
Langen
K J
KJ
Institute of Medicine, Research Center Jülich GmbH, D-52425, Jülich, Germany. k.j.langen@fz-juelich.de
Bonnie
R
R
Mühlensiepen
H
H
Jansen
P
P
Bröer
S
S
Holschbach
M
M
Coenen
H H
HH
D015703:Antigens, CD / Q000378:metabolism*; D001692:Biological Transport; D001932:Brain Neoplasms / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D027261:Fusion Regulatory Protein-1; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D007457:Iodine Radioisotopes; D008781:Methyltyrosines / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D002352:Carrier Proteins; D027261:Fusion Regulatory Protein-1; D007457:Iodine Radioisotopes; D008781:Methyltyrosines; D019275:Radiopharmaceuticals; C030855:3-iodo-alpha-methyltyrosine