Glycine reduces novelty- and methamphetamine-induced locomotor activity in neonatal ventral hippocampal damaged rats.
The use of neonatal ventral hippocampal nVH lesioned rats is well established in animal models of schizophrenia. Moreover, the dysfunction of N-methyl-D-aspartate (NMDA) neurotransmission may play a crucial role in the pathophysiology of schizophrenia. To examine the effect of glycine (GLY) in this animal model, we compared the effects of GLY (0.8 and 1.6 g/kg, IP) on locomotor activity induced by a novel environment (NOVEL) and methamphetamine (MAP, 1.5 mg/kg, IP) in lesioned and sham-operated rats. Compared with sham rats, GLY significantly reduced NOVEL- and MAP-induced locomotor activity in lesioned rats (p <.001 and p <.05, respectively). It is suggested that GLY attenuated nVH-induced hyperactivity, and that this effect was evident both in the presence and absence of MAP. The nVH lesions may result in a form of hyperactivity that differs from normal locomotion in the degree to which it is highly sensitive to regulation by GLY.
Kato
K
K
Department of Neuropsychiatry, Fukushima Medical University, School of Medicine, Fukushima, Japan. kkozo@fmu.ac.jp
Shishido
T
T
Ono
M
M
Shishido
K
K
Kobayashi
M
M
Niwa
S
S
D000818:Animals; D004195:Disease Models, Animal; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D006948:Hyperkinesis / Q000139:chemically induced*; D007051:Ibotenic Acid / Q000009:adverse effects; D008694:Methamphetamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D012559:Schizophrenia / Q000139:chemically induced / Q000503:physiopathology*
D016194:Receptors, N-Methyl-D-Aspartate; D007051:Ibotenic Acid; D008694:Methamphetamine; D005998:Glycine