Tumor progression: defining the soil round the tumor seed.
The tumor microenvironment, or stroma, is known to contribute to tumor progression. Two recent studies have shown that the stromal protein matrix metalloproteinase MMP-9 has a role in the early stages of tumor growth and angiogenesis.
McCawley
L J
LJ
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232-2175, USA.
Matrisian
L M
LM
D018450:Disease Progression; D020780:Matrix Metalloproteinase 9 / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology*; D009389:Neovascularization, Pathologic
D020780:Matrix Metalloproteinase 9