Dermatofibroma-like granular cell tumor.
BACKGROUND
There have been several reports in the literature of dermatofibromas with granular cells. Here we report a granular cell tumor with the architecture of a dermatofibroma. This is the first report of this histological variant of granular cell tumor. The lesion was a 2.5-cm oval, hyperpigmented plaque present for "years" on the back of a 60-year-old African-American woman.


METHODS
The specimen was processed using formalin fixation and paraffin embedding. Tissue sections were stained with hematoxylin and eosin. Immunohistochemical studies were performed with antibodies directed against S-100 protein, neuron-specific enolase, and factor XIIIa.


RESULTS
Histopathologic examination revealed granular cells, some of which were spindle shaped, distributed singly and in small groups between collagen bundles resembling a dermatofibroma. Immunohistochemical studies showed the tumor cells to be positive for S-100 and neuron-specific enolase and negative for factor XIIIa.


CONCLUSIONS
The immunohistochemical findings support the diagnosis of a granular cell tumor with a dermatofibroma-like pattern.
Cheng
S D
SD
The Ohio State University, University Medical Center, Columbus, USA.
Usmani
A S
AS
DeYoung
B R
BR
Ly
M
M
Pellegrini
A E
AE
D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*; D011503:Transglutaminases / Q000032:analysis
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D009418:S100 Proteins; D011503:Transglutaminases; D010751:Phosphopyruvate Hydratase