From ancient remedies to modern therapeutics: pine bark uses in skin disorders revisited.
The effect of French maritime pine bark extract (PBE) on the gene expression profile of HaCaT human keratinocytes was studied using high density filter arrays. The expression profile of both control and PBE-treated cells was determined. Interestingly, PBE was shown to downregulate both calgranulin A and B genes which are known to be upregulated in psoriasis and various dermatoses. Thus, PBE could be considered in human dermatoses.
Rihn
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B
Membrane Bioenergetics Group, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA. rihn@inrs.fr
Saliou
C
C
Bottin
M C
MC
Keith
G
G
Packer
L
L
D002460:Cell Line / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D005786:Gene Expression Regulation; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects*; D010936:Plant Extracts; D010946:Plants, Medicinal; D012871:Skin Diseases / Q000188:drug therapy / Q000235:genetics*
D005419:Flavonoids; D010936:Plant Extracts; C024070:pycnogenols