[Potential screening model for tissue specific calcium channel blockers]
Cardiovascular diseases are still the major cause of death in industrialized countries. The available therapies need improvement and specially tissue specific drugs. We have tested the possibility to establish cell lines expressing tissue specific cardiac muscular or smooth muscle L-type calcium channels. The cardiac and the smooth muscle L-type calcium channel differ in the IS6 segment of the alphaIC-gene. The established cell lines expressing the alphaIC-a or the alphaIC-b splice variants of the alphaIC-gene can be used for the screening of tissue specific calcium channel blockers.
Seisenberger
Claudia
C
Institut für Pharmakologie und Toxikologie der Technischen Universität München, D-München.
Hofmann
Franz
F