Role of potassium ions in monocyte-regulating effects of chorionic gonadotropin.
We studied the effects of chorionic gonadotropin on intracellular K(+)content and phagocytic activity of human peripheral blood monocytes. Since the immunomodulating properties of chorionic gonadotropin are known to depend on female sex steroids, the phase of the menstrual cycle was taken into account. Chorionic gonadotropic modulated the content of intracellular K(+)and phagocytic activity of monocytes. These changes were most pronounced under the effect of chorionic gonadotropin in high physiological doses (100 U/ml) and depended on the phase of the menstrual cycle. A direct correlation was found between elevation of K(+)content in monocytes and activation of phagocytosis during the luteal phase.
Shirshev
S V
SV
Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm', Russia.
Lyalina
O G
OG
Zamorina
S A
SA
D002414:Cations, Monovalent; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000378:metabolism* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010587:Phagocytosis / Q000187:drug effects; D011188:Potassium / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
D002414:Cations, Monovalent; D006063:Chorionic Gonadotropin; D011188:Potassium