title: Molecular analysis of Tn1546-like elements in vancomycin-resistant enterococci isolated from patients in Europe shows geographic transposon type clustering.
abstract: Resistance mechanism relatedness was studied in 18 clinical, European vanA vancomycin-resistant enterococci. Molecular analysis revealed 10 Tn1546-like elements, suggesting two evolutionary lineages. Lineage I dominated the European mainland, and lineage II dominated the United Kingdom and Israel. Geographic clustering reflected different types of meat consumption between countries, since each lineage is associated with colonization of different animals.
authors.affiliation: Department of Medical Microbiology, University Hospital St. Radboud, 6500 HB Nijmegen, The Netherlands. rschouten@rijnstate.nl
authors.forename: M A
authors.initials: MA
authors.lastname: Schouten
authors.forename: R J
authors.initials: RJ
authors.lastname: Willems
authors.forename: W A
authors.initials: WA
authors.lastname: Kraak
authors.forename: J
authors.initials: J
authors.lastname: Top
authors.forename: J A
authors.initials: JA
authors.lastname: Hoogkamp-Korstanje
authors.forename: A
authors.initials: A
authors.lastname: Voss
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001426:Bacterial Proteins / Q000235:genetics; D019729:Carbon-Oxygen Ligases / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004251:DNA Transposable Elements / Q000235:genetics*; D004739:England; D016983:Enterococcus / Q000235:genetics*; D005060:Europe; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D020713:Vancomycin Resistance / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements; C071437:VanA ligase, Bacteria; D019729:Carbon-Oxygen Ligases