A histological evaluation of TiO2-gritblasted and Ca-P magnetron sputter coated implants placed into the trabecular bone of the goat: Part 2.
The aim of this study was to investigate the synergetic influence of surface topography and chemical composition of oral implant materials on bone response. For the experiment screw designed implants were used. The implants were grit-blasted with TiO2 particles. The implants were left uncoated (Ti) or provided with three different amorphous/crystalline Ca-P magnetron sputter coatings, resp. 0.1 micron (CaP-0.1), 1 micron (CaP-1) and 4 microns (CaP-4), in thickness. The implants were inserted in the medial femoral condyles of 12 goats. Each femur received 2 implants. After implantation periods of 6 and 12 weeks the implants were retrieved and prepared for histological and histomorphometrical evaluation (bone contact and bone mass). The light microscopy revealed that bone response to CaP-4 and CaP-1 implants was similar. For example, after 12 weeks, screw threads were almost completely covered with bone. In contrast to CaP-0.1 and Ti implants, where bone apposition was less pronounced. Histomorphometry demonstrated that the bone-to-implant contact for the CaP-1 and CaP-4 implants was significantly higher (P < 0.05) than for the CaP-0.1 and Ti implants. This difference existed already after 6 weeks and was even enhanced after 12 weeks. The bone mass measurements revealed that only at 12 weeks CaP-4 implants had significantly more bone contact inside the screw threads than non-coated Ti-implants (P < 0.05). Supported by our findings, we conclude that the additional application of a 1-4 microns thick Ca-P magnetron sputter coating can further improve the healing response to surface roughened oral implants placed into trabecular bone.
Vercaigne
S
S
Department of Biomaterials, College of Dental Science, University of Nijmegen, POB 9101, 6500 HB Nijmegen, The Netherlands.
Wolke
J G
JG
Naert
I
I
Jansen
J A
JA
D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D016723:Bone Remodeling / Q000502:physiology; D001842:Bone and Bones / Q000473:pathology* / Q000601:surgery; D002130:Calcium Phosphates / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003461:Crystallography; D055590:Electromagnetic Phenomena; D005269:Femur / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006041:Goats; D008855:Microscopy, Electron, Scanning; D008872:Microwaves; D016348:Osseointegration; D010012:Osteogenesis / Q000502:physiology; D019736:Prostheses and Implants; D013223:Statistics as Topic; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014945:Wound Healing
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C009495:titanium dioxide; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; D014025:Titanium; C485829:calcium phosphate, dibasic, anhydrous