Suppression of hemopoiesis during CCl(4)-induced hepatic fibrosis: role of systemic endotoxemia.
CCl(4)-induced hepatic fibrosis in mice was accompanied by insufficiency of bone marrow myelo- and erythropoiesis. Polymyxin B completely abolished these changes. This phenomenon can be explained by the development of macrophage endotoxin tolerance during hepatic fibrosis.
Shvarts
Y S
YS
Institute of Therapy, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Zubakhin
A A
AA
Dushkin
M I
MI
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D019446:Endotoxemia / Q000209:etiology* / Q000473:pathology*; D006410:Hematopoiesis / Q000187:drug effects*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced* / Q000473:pathology*; D008264:Macrophages / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011112:Polymyxin B / Q000494:pharmacology
D002251:Carbon Tetrachloride; D011112:Polymyxin B