title: No beneficial effect of interferon-gamma treatment in 2 human immunodeficiency virus-infected patients with Mycobacterium avium complex infection.
abstract: Two human immunodeficiency virus-infected patients with refractory disseminated Mycobacterium avium complex infection were treated with recombinant interferon-gamma (IFN-gamma) given subcutaneously for 3 and 4 months, respectively. Although both patients demonstrated some clinical improvement initially, IFN-gamma therapy did not produce sustained benefit.
authors.affiliation: Department of Infectious Diseases, Tropical Medicine, and AIDS, Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: F N
authors.initials: FN
authors.lastname: Lauw
authors.forename: J T
authors.initials: JT
authors.lastname: van Der Meer
authors.forename: J
authors.initials: J
authors.lastname: de Metz
authors.forename: S A
authors.initials: SA
authors.lastname: Danner
authors.forename: T
authors.initials: T
authors.lastname: van Der Poll
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology; D000328:Adult; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D015269:Mycobacterium avium Complex; D015270:Mycobacterium avium-intracellulare Infection / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D007371:Interferon-gamma