The UNC-104/KIF1 family of kinesins.
Most UNC-104/KIF1 kinesins are monomeric motors that transport membrane-bounded organelles toward the plus ends of microtubules. Recent evidence implies that KIF1A, a synaptic vesicle motor, moves processively. This surprising behavior for a monomeric motor depends upon a lysine-rich loop in KIF1A that binds to the negatively charged carboxyl terminus of tubulin and, in the context of motor processivity, compensates for the lack of a second motor domain on the KIF1A holoenzyme.
Bloom
G S
GS
University of Virginia, Department of Biology, Gilmer Hall, Room 229, Charlottesville, Virginia 22903, USA. gsb4g@virginia.edu
D000818:Animals; D001693:Biological Transport, Active; D029742:Caenorhabditis elegans Proteins; D006801:Humans; D016547:Kinesins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D020409:Molecular Motor Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; C094065:KIF1A protein, human; D020409:Molecular Motor Proteins; D009419:Nerve Tissue Proteins; C423186:UNC-104 protein, C elegans; D016547:Kinesins