Effect of nicardipine and magnesiumon cerebral infarction - brain surface perfusion technique.
The protective effect of pre- and postischemia treatment of the brain by surface perfusion with nicardipine (Nic) and/or magnesium (Mg) was evaluated in a rat focal cerebral ischemia model. Artificial cerebrospinal fluid was perfused into the subarachnoid space of rats, containing Nic or Nic/Mg prior to vessel occlusion and Nic/Mg after occlusion. Reductions in the total amount of glutamate in the microdialysis perfusate and the volume of infarction tissue stained with 2,3,5-triphenyltetrazolium chloride were significant in all treated groups, even in rats treated after ischemia. An additive effect of Mg was also observed. These results suggest that this method may have clinical applications in patients suffering from ischemic insult.
Mikami
C
C
Department of Neurosurgery, Iwate Medical University School of Medicine, Morioka, Japan.
Suzuki
M
M
Tsuiki
K
K
Ogawa
A
A
D000287:Administration, Topical; D000818:Animals; D001921:Brain / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000378:metabolism; D004338:Drug Combinations; D005110:Extracellular Space / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D017078:Laser-Doppler Flowmetry; D008274:Magnesium / Q000627:therapeutic use*; D008297:Male; D017551:Microdialysis; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009529:Nicardipine / Q000627:therapeutic use*; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley
D002121:Calcium Channel Blockers; D004338:Drug Combinations; D018696:Neuroprotective Agents; D018698:Glutamic Acid; D009529:Nicardipine; D008274:Magnesium