title: Immunohistochemical Expression of N-ras Oncogene is a Late Event in Head and Neck Carcinomas.
abstract: This study investigated the expression of the N-ras oncogene in routinely processed tissue sections from 133 patients with squamous cell carcinoma of the head and neck (SCCHN) by immunohistochemistry using anti-N-ras monoclonal antibody. N-ras expression was present in 67 of 133 (49.6%) cases. There was a highly significant correlation between N-ras expression and clinical stage of disease (P=0.003). This study confirmed that overexpression of the N-ras oncogene is common in SCCHN and that it may be an important event in the late stage of disease.
authors.affiliation: University of Cincinnati College of Medicine, Department of Otolaryngology-Head and Neck Surgery, Cincinnati, USA.
authors.forename: John S
authors.initials: JS
authors.lastname: McDonald
authors.forename: Keith M
authors.initials: KM
authors.lastname: Wilson
authors.forename: Peter
authors.initials: P
authors.lastname: Gartside
authors.forename: Robert L
authors.initials: RL
authors.lastname: Sonke
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Pavelic
authors.forename: Eric
authors.initials: E
authors.lastname: Okum
authors.forename: Julie
authors.initials: J
authors.lastname: Neanen
authors.forename: Jack L
authors.initials: JL
authors.lastname: Gluckman
authors.forename: Zlatko P
authors.initials: ZP
authors.lastname: Pavelic