Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain.
We report the identification of a fourth member of the VPS10 domain containing receptor family, SorCS2, highly expressed in the developing and mature murine central nervous system. During early central nervous system development its main site of expression is the floor plate. In addition, high transcript levels were detected transiently in a variety of brain regions including the dopaminergic midbrain nuclei and the dorsal thalamus. Outside the nervous system expression is detected in lung and heart and transiently in a variety of mesodermally derived tissues.
Rezgaoui
M
M
Zentrum für Molekulare Neurobiologie, Universität Hamburg, Martinistrasse 52, D- 20246, Hamburg, Germany.
Hermey
G
G
Riedel
I B
IB
Hampe
W
W
Schaller
H C
HC
Hermans-Borgmeyer
I
I
D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D005656:Fungal Proteins / Q000096:biosynthesis*; D006321:Heart / Q000196:embryology; D017403:In Situ Hybridization; D008168:Lung / Q000196:embryology; D008636:Mesencephalon / Q000196:embryology; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics*; D009474:Neurons / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins; D014018:Tissue Distribution; D033921:Vesicular Transport Proteins
D018076:DNA, Complementary; D005656:Fungal Proteins; D009419:Nerve Tissue Proteins; C087335:PEP1 protein, S cerevisiae; D011956:Receptors, Cell Surface; D029701:Saccharomyces cerevisiae Proteins; C426856:SorCS2 protein, mouse; D033921:Vesicular Transport Proteins