Effects of nootropics on electrical activity in rat hippocampal CA1 area.
Experiments on rat hippocampal slices showed that high concentrations of nooglutil and mexidol, but not piracetam, suppressed the ortho- and antidromic population responses in the CA1 area evoked by paired stimulation, the orthodromic responses being more sensitive to the drugs. The effects of both drugs were blocked by AP7, a specific antagonist of N-methyl-D-aspartate receptors. It is suggested that N-activation of methyl-D-aspartate receptors by high concentrations of nooglutil and mexidol reduced CA1 pyramidal cell responsiveness.
Motin
V
V
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
Yasnetsov
V
V
Kovalev
S
S
Krylova
I
I
D000818:Animals; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018697:Nootropic Agents