[An experimental study on the effect of xenogeneic bone combined with human recombinant bone morphogenetic protein-2].
OBJECTIVE
To determine the ability of a new type of composited xenogeneic bone to repair the bone defect.


METHODS
The new type of composited xenogeneic bone was obtained by combining the treated cancellous bone with recombinant human bone morphogenetic protein-2 (rhBMP-2) and was implanted in the bone defect of rabbit.


RESULTS
There were a large amount of new bone formation within the combined material and the amount was increasing as the time lapsed in the area of the bone defect. In contrast, there were a lot of fibrous tissues with a little new bone formed when the treated cancellous bone was implanted alone.


CONCLUSIONS
The results imply that the rhBMP-2 plays a very important role in new bone formation and the composited xenogeneic bone appears to be an ideal material for the repair of bone defect.
Wang
C
C
Stomatological College, Fourth Military Medical University, Xi'an 710032.
Mao
T
T
Zhao
M
M
D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D016025:Bone Transplantation; D006801:Humans; D051379:Mice; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D016212:Transforming Growth Factor beta; D014183:Transplantation, Heterologous / Q000379:methods; D016042:Transplantation, Heterotopic / Q000379:methods
C525718:BMP2 protein, human; C525719:Bmp2 protein, mouse; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2