title: Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.
abstract: Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2'-oxygen and the 4'-carbon. This conformation restriction increases binding affinity for complementarity sequences and provides an exciting new chemical approach for the control of gene expression and optimization of microarrays.
authors.affiliation: Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Braasch
authors.forename: D R
authors.initials: DR
authors.lastname: Corey
mesh_terms: D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004355:Drug Stability; D004789:Enzyme Activation; D015870:Gene Expression; D066298:In Vitro Techniques; D009696:Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D020135:Peptide Nucleic Acids / Q000737:chemistry / Q000378:metabolism; D012313:RNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D016914:Ribonuclease H / Q000378:metabolism
chemical_list: D009696:Nucleic Acids; D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA; D016914:Ribonuclease H