title: The optimum time to employ telephotoscreening to detect retinopathy of prematurity.
abstract: OBJECTIVE
  Labor-intensive screening of infants in the neonatal intensive care units is the only way to detect retinopathy of prematurity (ROP). Our purpose is to determine if RetCam 120 photos, acquired by a neonatal nurse, can be used to screen for ROP by performing 2 screening examinations, at 32 to 34 weeks (exam 1) and at 38 to 40 weeks (exam 2) post-conceptional age.
  
  
  METHODS
  RetCam examinations are performed by a nurse on infants at exam 1 and exam 2 intervals. At the same time, an examination is performed by an experienced ophthalmologist. Masked readers evaluate the photos for ROP and determine if each eye will progress to prethreshold or threshold disease. The data are compared to the clinical course of the eyes.
  
  
  RESULTS
  Forty-six eyes were photographed at exam 1 and 50 eyes at exam 2 from July 1, 1999, to December 15, 1999. Sensitivity and specificity of detecting ROP were 76% and 100% for exam 2 and 46% and 100% for exam 1. Sensitivity and specificity of predicting prethreshold disease were 64% and 97% for exam 2 and 33% and 100% for exam 1. Sensitivity and specificity of predicting threshold were both 100% at exam 2 and 0% (one photo in category) and 95% at exam 1.
  
  
  CONCLUSIONS
  A potential reason for low sensitivity is technical limitations of the Retcam, such as the difficulty in capturing peripheral retina in small eyes and the need for a better lid speculum.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA.
authors.forename: K G
authors.initials: KG
authors.lastname: Yen
authors.forename: D
authors.initials: D
authors.lastname: Hess
authors.forename: B
authors.initials: B
authors.lastname: Burke
authors.forename: R A
authors.initials: RA
authors.lastname: Johnson
authors.forename: W J
authors.initials: WJ
authors.lastname: Feuer
authors.forename: J T
authors.initials: JT
authors.lastname: Flynn
mesh_terms: D018450:Disease Progression; D006801:Humans; D007231:Infant, Newborn; D009726:Nurses; D009885:Ophthalmology / Q000379:methods; D010781:Photography; D010808:Physical Examination; D011237:Predictive Value of Tests; D011379:Prognosis; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D019113:Telepathology