Antioxidant capacity of G-6-PD-deficient erythrocytes.
Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency is the most common human enzymopathy. In this research, we studied two groups consisting of 30 male subjects who are G-6-PD deficient and 30 normal male subjects matched with the G-6-PD-deficient patients for age. All 30 assays were performed under normal conditions free of any oxidative attack that may result in haemolytic crisis in G-6-PD-deficient subjects. The erythrocyte glucose-6-phosphate dehydrogenase, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST) activities, reduced glutathione (GSH) levels and erythrocyte and plasma thiobarbituric acid-reactive substances (TBARS) levels were measured. All parameters in each group did not differ significantly except for G-6-PD levels. These data show that G-6-PD-deficient subjects can survive in normal conditions unless they are exposed to any oxidative stress.
Bilmen
S
S
Department of Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey. bilmen@hipokrat.med.akdeniz.edu.tr
Aksu
T A
TA
Gümüşlü
S
S
Korgun
D K
DK
Canatan
D
D
D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D004912:Erythrocytes / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood*; D006801:Humans; D008297:Male
D000975:Antioxidants; D005954:Glucosephosphate Dehydrogenase