title: Inhibition of rubella virus growth by Fungizone.
abstract: Fungizone added to agar overlay medium inhibited plaque formation in both size and number by rubella virus in rabbit kidney 13 cells. In the presence of 1 microg/ml of Fungizone, the diameter of the plaques was reduced to one half of that in the absence of the drug, and at 5 microg/ml, plaque formation was inhibited by 80%. When the drug was added to the culture medium, the growth of infectious virus was also inhibited with reduction in the synthesis of envelope glycoprotein E1 and capsid protein C in infected cells.
authors.affiliation: Department of Viral Diseases and Vaccine Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, 208-0011, Tokyo, Japan.umino@nih.go.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Umino
authors.forename: M
authors.initials: M
authors.lastname: Tashiro
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002213:Capsid / Q000096:biosynthesis; D002460:Cell Line; D011817:Rabbits; D012412:Rubella virus / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D014758:Viral Core Proteins / Q000096:biosynthesis; D014759:Viral Envelope Proteins / Q000096:biosynthesis; D010948:Viral Plaque Assay; D014776:Virus Cultivation
chemical_list: D000900:Anti-Bacterial Agents; D014758:Viral Core Proteins; D014759:Viral Envelope Proteins; C074573:nucleocapsid protein (C), rubella virus; C061826:E1 envelope protein, Rubella virus; D000666:Amphotericin B