Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers.
Several types of virus were found to have a strong association with different types of cancers. Thus, a selective antiviral compound without toxicity upon long-term usage will be useful not only for the treatment of viral diseases but also for the prevention or the delayed onset of those cancers, which have a strong association with viruses. L(-)Nucleoside analogs were discovered recently in my laboratory as an important class of antiviral and anticancer chemical entities. L(-)SddC (3TC, Lamivudine), FTC, Fd4C, and L(-)FMAU are potent anti-HBV compounds with different pharmacological profiles. These compounds may be useful in the prevention or delayed onset of hepatocellular carcinoma associated with HBV. L(-)I-OddU is the most potent anti-Epstein-Barr Virus (EBV) compound without cytotoxicity and animal toxicity upon long-term dosing which gives the pharmacological levels of the drug in plasma. This compound may have the potential to prevent B-cell lymphoma associated with patients undergoing organ transplants in addition to its potential use for the treatment of EBV infection.
Cheng
Y C
YC
Department of Pharmacology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, USA.
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives / Q000494:pharmacology; D004148:Dioxolanes / Q000494:pharmacology; D006515:Hepatitis B virus / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000209:etiology; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives / Q000494:pharmacology; D014777:Virus Diseases / Q000150:complications / Q000517:prevention & control* / Q000821:virology; D016047:Zalcitabine / Q000031:analogs & derivatives* / Q000494:pharmacology
C419688:5-iododioxolane uracil; D000998:Antiviral Agents; D004148:Dioxolanes; D009705:Nucleosides; D001086:Arabinofuranosyluracil; D014498:Uracil; D016047:Zalcitabine; C034935:clevudine; C099405:dexelvucitabine