[Prediction of final height in girls with Turner syndrome treated with growth hormone].
Treatment with growth hormone (GH) in girls with Turner syndrome (TS) would improve growth velocity (GV) and final height (FH) prediction. A total of 21 girls with TS treated with GH for 1 (n = 21), 2 (n = 18) and 3 years (n = 10) were studied. At the onset of GH treatment, the mean chronological age was 11.6 +/- 2.6 years and the mean bone age was 9.7 +/- 2.4 years. The mean height SDS was: -0.04 +/- 1.0 at the beginning, 0.4 +/- 1.0 at 1st year, 0.9 +/- 1.1 at 2nd year and 1.25 +/- 0.56 at 3rd year of treatment (p = 0.0001, p < 0.0001 and p < 0.05 respectively). The mean GV SDS was 1.6 +/- 1.8 at the beginning, 2.5 +/- 1.7 at 1st year, 3.8 +/- 2.9 at 2nd year and 2.2 +/- 2.0 at 3rd year (p = 0.01, p = 0.04 and p = 0.29 respectively). The FH prediction by Bayley-Pinneau method was: 142.8 +/- 5.2 cm at the beginning, 143.8 +/- 6.0 at 1st year, 146.0 +/- 5.9 at 2nd year and 145.6 +/- 6.4 at 3rd year (p = 0.026, p = 0.05 y p = 0.87 respectively). The mean ending height treatment (EH), in 8 patients, was 145.1 cm +/- 6.7. In conclusion, 1) studied patients showed systematic bone age delay at the beginning of GH treatment; 2) during the treatment, GV increment and improvement in relative heights and in FH prediction were observed; 3) the EH, nearest to the FH prediction, previously made at 3rd year of treatment, was 7.2 cm higher than mean FH's for Argentinean girls with TS without GH treatment.
Morin
A
A
Unidad de Endocrinología y Crecimiento, Hospital Sor S.M. Ludovica, calle 14 No. 1631, 1900 La Plata, Argentina. Imguima@museo.fcnym.unlp.edu.ar
Guimarey
L
L
Santucci
Z
Z
Apezteguia
M
M
D001827:Body Height / Q000187:drug effects*; D002675:Child, Preschool; D005260:Female; D019382:Human Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000188:drug therapy*
D019382:Human Growth Hormone