Growth regulation by oncogenes--new insights from model organisms.
A great deal of work has focused on how oncogenes regulate the cell cycle during normal development and in cancer, yet their roles in regulating cell growth have been largely unexplored. Recent work in several model organisms has demonstrated that homologs of several oncogenes regulate cell growth and has suggested that some of the effects of oncogenes on the cell cycle may be a result of growth promotion. These studies have also suggested how growth and cell-cycle progression may be coupled.
Prober
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DA
Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA. dprober@u.washington.edu
Edgar
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BA
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D056741:Cyclin D; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism; D016213:Cyclins / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D018816:Genes, cdc; D016259:Genes, myc; D011905:Genes, ras; D006801:Humans; D009154:Mutation; D011518:Proto-Oncogene Proteins; D011519:Proto-Oncogenes; D013002:Somatomedins / Q000235:genetics / Q000378:metabolism
D056741:Cyclin D; D016213:Cyclins; D011518:Proto-Oncogene Proteins; D013002:Somatomedins; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases