Clinically relevant rat model for testing BOLD functional MR imaging techniques by using single-shot echo-planar imaging at 1.5 T.
By using a 1.5-T whole-body magnetic resonance (MR) imager, a high-spatial-resolution single-shot echo-planar technique was developed to perform blood oxygen level dependent functional MR imaging of rat sensory cortex during forepaw stimulation. This technique produced cubic 1-mm(3) voxels. Signal-to-noise ratio was 140-160 (43-44 dB). Optimal effective echo time was 50 msec. This system should prove useful for developing new functional MR imaging techniques with rapid adaptation to human use.
Morton
D W
DW
Departments of Radiology, University of Washington, 1959 NE Pacific St, Box 357115, Seattle, WA 98195, USA.
Maravilla
K R
KR
Meno
J R
JR
Winn
H R
HR
D000818:Animals; D001921:Brain / Q000473:pathology*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley
D010100:Oxygen