title: A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis.
abstract: Vascular polarity is a fundamental feature of angiogenesis and left-right asymmetry of the vascular network. Contrary to this importance, the molecular basis of vascular polarity is completely unknown. In this report, we show that the combinatorial function of angiopoietin-1 and the orphan receptor TIE1 is critical specifically for the development of the right-hand side venous system but is dispensable for the left-hand side venous system. Furthermore, our current finding reveals the existence of a distinct genetic program for the establishment of the right-hand side and left-hand side vascular networks well before the network asymmetry becomes morphologically discernible.
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
authors.forename: S
authors.initials: S
authors.lastname: Loughna
authors.forename: T N
authors.initials: TN
authors.lastname: Sato
mesh_terms: D042683:Angiopoietin-1; D000818:Animals; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D018919:Neovascularization, Physiologic / Q000502:physiology*; D010641:Phenotype; D012333:RNA, Messenger / Q000032:analysis; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D042810:Receptor, TIE-1; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D042764:Receptors, TIE; D014682:Vena Cava, Inferior / Q000196:embryology* / Q000201:enzymology; D014683:Vena Cava, Superior / Q000196:embryology* / Q000201:enzymology
chemical_list: D042683:Angiopoietin-1; C467628:Angpt1 protein, mouse; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D020794:Receptor Protein-Tyrosine Kinases; D042810:Receptor, TIE-1; D042764:Receptors, TIE