title: Photodynamic therapy with verteporfin for age-related macular degeneration. American Academy of Ophthalmology.
abstract: OBJECTIVE
  This document describes photodynamic therapy (PDT) with verteporfin for age-related macular degeneration (AMD) and examines the evidence to answer the key question about whether the treatment is safe and effective in reducing visual loss from AMD.
  
  
  METHODS
  A literature search that was conducted in April 2000 retrieved eight relevant citations, and the reference lists of these articles were consulted for additional citations. Panel members reviewed this information, and a methodologist reviewed and rated all articles according to the strength of evidence.
  
  
  RESULTS
  The published literature contains a report of the combined results from two identically designed, double-masked randomized controlled trials. Ninety-four percent of participants completed the one-year follow-up. Patients treated with verteporfin had a decreased risk of at least moderate visual loss over this one-year period, but the beneficial effect on visual acuity was greatest among eyes in which the area of classic choroidal neovascularization (CNV) occupied 50% or more of the entire lesion area. There was no statistically significant difference in visual acuity outcomes at one year for yees in which the classic CNv was more than 0% but less than 50% of the area of the entire lesion. Serious systemic complications were rare. Severe vision decrease (equivalent to four lines or more of vision) within 7 days of treatment with verteporfin has been reported in 1% to 4% of patients. Partial recovery of vision was observed in many of these patients.
  
  
  CONCLUSIONS
  To date, evidence suggests that PDT using verteporfin can reduce the risk of visual loss in patients with predominantly classic subfoveal CNV from AMD at one year. The rate of ocular and systemic complications is low. Additional clinical research is needed to determine the long-term effectiveness of treatment and the comparitive effectiveness with existing and new treatment modalities under investigation.
mesh_terms: D020256:Choroidal Neovascularization / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000188:drug therapy*; D009885:Ophthalmology / Q000592:standards*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D012449:Safety; D013673:Technology Assessment, Biomedical / Q000592:standards*; D016896:Treatment Outcome; D000077362:Verteporfin; D014786:Vision Disorders / Q000209:etiology / Q000517:prevention & control; D014792:Visual Acuity
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin