title: Increased prevalence of atopy among children exposed to mold in a school building.
abstract: BACKGROUND
  The purpose of this study was to assess the occurrence of immunoglobulin E sensitization to common environmental allergens (atopy) and new allergic diseases among schoolchildren after starting school in a water-damaged school building. The staff and pupils of a Finnish elementary school with visible water damage and mold complained of respiratory and skin symptoms. The school building was examined and widespread moisture damage was found. A control school with no visible water damage was also examined. No indication of exceptional microbial growth was found in the samples taken from this school.
  
  
  METHODS
  History of allergic diseases and the year of diagnosis were established by a questionnaire. IgE antibodies to the common environmental allergens were determined from randomly selcted groups from both schools.
  
  
  RESULTS
  Elevated IgE values were significantly more common among the exposed children, as was the occurrence of new allergic diseases after the children started at the school.
  
  
  CONCLUSIONS
  The odds ratios for the IgE values of the study groups indicated a possible relationship between exposure to microorganisms and IgE sensitization. Exposure to spores, toxins, and other metabolites of molds may have complex results with unknown immunogenic effects that may act as a nonspecific trigger for allergic sensitization leading to the development of atopy.
authors.affiliation: Espoo Health Centre, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Savilahti
authors.forename: J
authors.initials: J
authors.lastname: Uitti
authors.forename: P
authors.initials: P
authors.lastname: Roto
authors.forename: P
authors.initials: P
authors.lastname: Laippala
authors.forename: T
authors.initials: T
authors.lastname: Husman
mesh_terms: D002648:Child; D004781:Environmental Exposure; D005260:Female; D005387:Finland; D005658:Fungi / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012574:Schools; D011795:Surveys and Questionnaires
chemical_list: D007073:Immunoglobulin E