Chemokines and disease.
We examine here several diseases that are associated with inappropriate activation of the chemokine network. Detailed comment has been restricted to pathological states for which there are compelling data either from clinical observations or animal models. These include cardiovascular disease, allergic inflammatory disease, transplantation, neuroinflammation, cancer and HIV-associated disease. Discussion focuses on therapeutic directions in which the rapidly evolving chemokine field appears to be headed.
Gerard
C
C
Department of Pediatrics, Perlmutter Laboratory, Children's Hospital, Boston, MA, USA. gerard_c@gonzo.tch.harvard.edu
Rollins
B J
BJ
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001249:Asthma / Q000276:immunology; D018925:Chemokines / Q000276:immunology*; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D015658:HIV Infections / Q000276:immunology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology; D009369:Neoplasms / Q000276:immunology; D019707:Receptors, Chemokine / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D014652:Vascular Diseases / Q000276:immunology
D018925:Chemokines; D019707:Receptors, Chemokine