Synovial cytokine mRNA expression during arthritis triggered by CpG motifs of bacterial DNA.
Our results show that cytokines derived from macrophages play an important role in pathogenesis of arthritis triggered by CpG oligodinucleotide (CpG ODN). IL-12 is in this respect an important immunomodulator during the development of joint inflammation.
Deng
G M
GM
Department of Rheumatology, University of Göteborg, Göteborg, Sweden. guo-min@immuno.gu.se
Tarkowski
A
A
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D002474:Cell-Free System / Q000276:immunology; D002478:Cells, Cultured; D018899:CpG Islands / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology / Q000378:metabolism; D004269:DNA, Bacterial / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D018664:Interleukin-12 / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009838:Oligodeoxyribonucleotides / Q000008:administration & dosage / Q000276:immunology*; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000276:Adjuvants, Immunologic; C408982:CPG-oligonucleotide; D016207:Cytokines; D004269:DNA, Bacterial; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12