Perinatal risk factors for cranial ultrasound abnormalities in neonates born after spontaneous labour before 34 weeks.
OBJECTIVE
The aim of this study was to identify risk factors for cranial ultrasound abnormalities in neonates born after spontaneous preterm labour with or without prolonged premature rupture of the membranes (PROM).


METHODS
The presence of intraventricular haemorrhage and cystic periventricular leucomalacia was investigated in a cohort of neonates born between 24 and 34 weeks using cranial ultrasound. A stepwise forward logistic regression was performed to analyse the influence of antenatal and postnatal variables on cranial ultrasound abnormalities.


RESULTS
The study group consisted of 205 neonates and cranial ultrasound abnormalities were identified in 27 infants. Early onset neonatal infectious disease (OR 3.09, 95% CI 1.24--7.70, P=0.01) increased the risk for cranial ultrasound abnormalities. Gestational age at birth (OR 0.96, 95% CI 0.93--0.99, P=0.03) and a full course of antenatal steroids (OR 0.33, 95% CI 0.13--0.85, P=0.02) reduced the risk for cranial ultrasound abnormalities.


CONCLUSIONS
Early onset neonatal infectious disease is an independent risk factor for cranial ultrasound abnormalities in the very preterm neonate born after spontaneous labour with or without PROM.
Vermeulen
G M
GM
Department of Obstetrics and Gynaecology, Diaconessenhuis Meppel, PO Box 502, NL 7940 AM Meppel, The Netherlands. vermeulengm@diacmeppel.nl
Bruinse
H W
HW
Gerards
L J
LJ
de Vries
L S
LS
D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D004453:Echoencephalography; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007239:Infections / Q000453:epidemiology; D015931:Intensive Care, Neonatal; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D012121:Respiration, Artificial; D012307:Risk Factors; D013256:Steroids / Q000008:administration & dosage; D013997:Time Factors; D015145:Tocolysis; D014427:Twins
D013256:Steroids