DNA damage: Chk1 and Cdc25, more than meets the eye.
Control of mitotic entry is a component of the checkpoint response that contributes to cell survival following DNA damage. In some eukaryotic cells, mitotic entry relies heavily on regulation of the state of tyrosine phosphorylation of the cyclin-dependent kinase Cdc2. Evidence that checkpoint regulation of cell-cycle progression operates through controlling the state of Cdc2 tyrosine phosphorylation exists. Whether other targets of the checkpoint pathway could play important roles in the response to DNA damage is a subject of ongoing investigations.
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Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, The Cancer Institute of New Jersey, 675 Hoes Lane, Piscataway, New Jersey 08854-5635, USA. walworna@umdnj.edu
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism; D000071877:Checkpoint Kinase 1; D004249:DNA Damage / Q000235:genetics*; D005656:Fungal Proteins / Q000378:metabolism; D018816:Genes, cdc; D006801:Humans; D008938:Mitosis; D011494:Protein Kinases / Q000378:metabolism*; D015003:Yeasts / Q000235:genetics / Q000378:metabolism; D020687:cdc25 Phosphatases / Q000378:metabolism*; D020666:ras-GRF1 / Q000378:metabolism
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D020666:ras-GRF1; D011494:Protein Kinases; C000605867:CHEK1 protein, human; D000071877:Checkpoint Kinase 1; D016203:CDC2 Protein Kinase; D020687:cdc25 Phosphatases