title: Evolution of prokaryotic gene order: genome rearrangements in closely related species.
abstract: Conservation of gene order in prokaryotes has become important in predicting protein function because, over the evolutionary timescale, genomes are shuffled so that local gene-order conservation reflects the functional constraints within the protein. Here, we compare closely related genomes to identify the rate with which gene order is disrupted and to infer the genes involved in the genome rearrangement.
authors.affiliation: EMBL, Meyerhofstr. 1, D-69012 Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Suyama
authors.forename: P
authors.initials: P
authors.lastname: Bork
mesh_terms: D019143:Evolution, Molecular; D015321:Gene Rearrangement; D016678:Genome; D011387:Prokaryotic Cells