title: The best defense is a good offense--Salmonella deploys an ADP-ribosylating toxin.
abstract: The dramatic clinical manifestations of toxigenic infections such as cholera and diphtheria occur without substantial bacterial invasion. Disease is mediated by the secretion of potent toxins that use ADP-ribosylation as the catalytic mechanism underlying their action. ADP-ribosylating toxins comprise a large family, including the cholera, diphtheria, pertussis and Escherichia coli heat-labile (LT) toxins, and all produce disease by altering key metabolic processes after transfer of an ADP-ribose moiety from NAD to specific host-cell target proteins. A new paradigm implicating ADP-ribosylation during intracellular pathogenesis is beginning to emerge from recent research in Salmonella.
authors.affiliation: Department of Medicine, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0640, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Lesnick
authors.forename: D G
authors.initials: DG
authors.lastname: Guiney
mesh_terms: D036002:ADP Ribose Transferases / Q000378:metabolism*; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001427:Bacterial Toxins / Q000378:metabolism*; D017124:Conserved Sequence; D004731:Endotoxins / Q000378:metabolism*; D004768:Enterotoxins / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D012475:Salmonella / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D037521:Virulence Factors
chemical_list: D001427:Bacterial Toxins; D004731:Endotoxins; D004768:Enterotoxins; D037521:Virulence Factors; C027952:salmonella toxin; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D036002:ADP Ribose Transferases; C415223:spvB protein, Salmonella enterica virulence plasmid