Quantitation of lipid-laden macrophages in evaluation of lower airway cytology specimens from pediatric patients.
Quantitation of lipid-laden macrophages has been used as a tool in the diagnosis of aspiration-related respiratory disorders. Fifty-six respiratory specimens from pediatric patients with lung diseases were retrospectively reviewed, and lipid-laden macrophage indices were evaluated according to modified published grading methods. The indices from patients at high risk for aspiration were significantly different from those at low risk. A simpler and more reproducible grading method was introduced. An important issue regarding sample adequacy was also addressed.
Yang
Y J
YJ
Department of Pathology, Upstate Medical University, State University of New York, 750 East Adams Street, Syracuse, NY 13210, USA. YangY@upstate.edu
Steele
C T
CT
Anbar
R D
RD
Sinacori
J T
JT
Powers
C N
CN
D000293:Adolescent; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D003581:Cytodiagnosis; D006801:Humans; D007223:Infant; D050356:Lipid Metabolism; D008264:Macrophages / Q000378:metabolism / Q000473:pathology*; D015588:Observer Variation; D011015:Pneumonia, Aspiration / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012189:Retrospective Studies