Synthesis of a novel lysophosphatidylcholine.
The novel lysophosphatidylcholine (1), which naturally occurs in the marine sponge Spirastrella abata and was reported to inhibit cholesterol biosynthesis in the Chang liver cell, has been synthesized in four steps from methyl cis-11-octadecenoate (2).
Zhu
C
C
Department of Natural Science, Graduate School of Okayama University, Okayama 700-8530, Japan. zhuchangjin@hotmail.com
Morimoto
T
T
Nakajima
S
S
Nitoda
T
T
Baba
N
N
D007202:Indicators and Reagents; D008244:Lysophosphatidylcholines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment
C428180:1-O-(11',12'-methylene-octadecanoyl)glycero-3-phosphocholine; D007202:Indicators and Reagents; D008244:Lysophosphatidylcholines