Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat.
Orexin A (10-300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 microM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy.
Brown
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RE
Institut für Neurophysiologie, Heinrich-Heine-Universität, D-40001, Düsseldorf, Germany. brown@uni-duesseldorf.de
Sergeeva
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O
Eriksson
K S
KS
Haas
H L
HL
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D002352:Carrier Proteins / Q000494:pharmacology*; D066298:In Vitro Techniques; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009290:Narcolepsy / Q000378:metabolism; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009479:Neuropeptides / Q000494:pharmacology*; D000068797:Orexins; D018408:Patch-Clamp Techniques; D011903:Raphe Nuclei / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D017366:Serotonin Receptor Agonists; D012701:Serotonin; D013779:Tetrodotoxin