[Significance of nm23 expression in malignant carcinoma of salivary gland].
In recent years, a tumor suppressor gene nm23 has been found to be associated with decreased tumor metastatic potential. Allelic deletion, mutation and low expression of this gene has been correlated with tumor metastatic potential in a number of tumors. We examined the expression of nm23 in 40 cases of salivary gland malignant carcinomas by immunohistochemical method. The results showed that nm23 lower expression tumors were associated with a higher rate of metastasis (81.8%) than nm23 higher expression (3.4%, P < 0.005). There is no correlation between nm23 lower expression and tumor size, location and pathologic type (P > 0.05). This result indicates that nm23 gene plays an important role in the metastasis of salivary gland malignant carcinoma.
Jin
H
H
School of Stomatology, Hubei Medical University, Wuhan 430070.
Li
J
J
Chen
X
X
D000328:Adult; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000096:biosynthesis*; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors / Q000096:biosynthesis*
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins