title: Separation of chiral 4-substituted imidazole derivatives by cyclodextrin-modified capillary electrophoresis.
abstract: Enantiomeric separations by cyclodextrin-modified capillary electrophoresis of chiral carbamates containing a 4-substituted imidazole heterocycle, pharmacologically acting as histamine H3-receptor antagonists, were carried out. Various cyclodextrins (alpha-, beta- and substituted beta-cyclodextrins) were investigated. Baseline resolution was achieved with six out of 11 compounds. Heptakis-2,3,6-trimethyl-beta-cyclodextrin modified buffers seemed to be most efficient in separating most of the investigated compounds. The optical purity of one pair of enantiomers was determined.
authors.affiliation: Institut für Pharmazie, Freie Universität Berlin, Königin-Luise-Strasse 2 + 4, 14195 Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Sasse
authors.forename: W
authors.initials: W
authors.lastname: Schunack
authors.forename: H
authors.initials: H
authors.lastname: Stark
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D003505:Cyclodextrins; D007093:Imidazoles