title: Elevated vitreous concentration of monoclonal immunoglobulin manifesting as schlieren in juvenile rheumatoid arthritis-associated uveitis.
abstract: We report the clinical findings and analysis of the immunoglobulin (Ig) composition of the vitreous of a 10-year-old girl with juvenile rheumatoid arthritis-associated uveitis. The vitreous had a schlieren appearance at the time of pars plana lensectomy and vitrectomy. Analysis of the vitreous fluid revealed marked elevation of IgG, IgM, IgA, and albumin levels relative to vitreous fluids from control patients without uveitis. The immunoglobulin coefficients were also elevated for the IgG and IgM classes of immunoglobulins. Immunofixation electrophoresis of the vitreous fluid revealed 2 distinct bands of restricted electrophoretic mobility. These studies suggest that there may be local (intraocular) production of immunoglobulins as an immunologic response in ocular inflammatory diseases such as juvenile rheumatoid arthritis-associated uveitis and that this immunologic response may be monoclonal (possibly biclonal or oligoclonal) in nature.
authors.affiliation: Maumenee Building, Room 738, Wilmer Ophthalmological Institute, the Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, Md 21287, USA. mhumayun@jhmi.edu
authors.forename: Q D
authors.initials: QD
authors.lastname: Nguyen
authors.forename: R L
authors.initials: RL
authors.lastname: Humphrey
authors.forename: J P
authors.initials: JP
authors.lastname: Dunn
authors.forename: M S
authors.initials: MS
authors.lastname: Humayun
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000378:metabolism; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology / Q000601:surgery; D007136:Immunoglobulins / Q000378:metabolism*; D007908:Lens, Crystalline / Q000601:surgery; D008875:Middle Aged; D012030:Refractive Errors / Q000209:etiology*; D054140:Refractive Surgical Procedures; D014605:Uveitis / Q000209:etiology* / Q000276:immunology; D014821:Vitrectomy; D014822:Vitreous Body / Q000276:immunology*
chemical_list: D000418:Albumins; D007136:Immunoglobulins