title: Analgesic activity of the lignans from Lychnophora ericoides.
abstract: Lychnophora ericoides is a Brazilian medicinal plant that is commercially available as an analgesic and anti-inflammatory agent. The extract from roots, which yielded 10 lignans, showed analgesic activity in the mouse writhing test and the lignan, cubebin, was one of the most active. Anti-inflammatory and anti-pyretic activities from cubebin (10 mg/kg) revealed no significant effects. In addition two previously unknown methyl clusin derivatives are reported.
authors.affiliation: Departamento de Fisica e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Brazil.
authors.forename: M L
authors.initials: ML
authors.lastname: Borsato
authors.forename: C F
authors.initials: CF
authors.lastname: Grael
authors.forename: G E
authors.initials: GE
authors.lastname: Souza
authors.forename: N P
authors.initials: NP
authors.lastname: Lopes
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000700:Analgesics; D017705:Lignans