title: [Analysis on associations of cytochrome P450 1A1-Hinc II and glutathion S-transferase-theta with primary dysmenorrhea].
abstract: OBJECTIVE
  To investigate the genetic susceptibility to primary dysmenorrhea.
  
  
  METHODS
  Data of 499 female workers in a textile mill were collected. The associations of cytochrome P450 1A1-Hinc II(CYP 1A1-Hinc II) and glutathion S-transferase-theta(GSTT1) polymorphisms with heavy primary dysmenorrhea were evaluated by Logistic regression, with adjustment for potential confounders.
  
  
  RESULTS
  The result showed variant of CYP1A1- Hinc II genotypes slightly reduced the risk of primary dysmenorrhea, but its OR value was not statistically significant (CYP1A1-Hinc II:OR=0.64, 95% CI 0.35-1.17). The GSTT1 genotype variant increased the risk of primary dysmenorrhea (GSTT1:OR=1.83, 95% CI 1.04-3.21). After potential confounders were adjusted, the data showed that CYP1A1-Hinc II variant had the trend of decreasing the risk of dysmenorrhea (CYP1A1-Hinc II:OR=0.58, 95% CI 0.31-1.08), but its decreasing scope was still not statistically significant. The GSTT1 variant genotypes showed a significantly increased risk of dysmenorrhea (GSTT1:OR=2.01, 95% CI 1.12-3.62).
  
  
  CONCLUSIONS
  The results suggested that GSTT1 polymorphism be associated with heavy primary dysmenorrhea.
authors.affiliation: The Biomedical Institute of Anhui Medical University, Hefei, Aihui, 230032 P.R. China. ppgamu@mail.hf.ah.cn
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Ni
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: X
authors.initials: X
authors.lastname: Xu
mesh_terms: D000328:Adult; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004412:Dysmenorrhea / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D019363:Cytochrome P-450 CYP1A1; C413545:glutathione S-transferase T1; D005982:Glutathione Transferase