Cytoskeletal changes in cell transformation and tumorigenesis.
Research during the past couple of years has provided important new information as to how the actin cytoskeleton contributes to growth control in both normal and transformed cells. The cytoskeleton can no longer be viewed as simply a structural framework playing a role in cell shape and motile events such as cell movement, intracellular transport, contractile-ring formation and chromosome movement. More recent experiments show that the cytoskeleton plays a critical role in the regulation of various cellular processes linked to transformation including proliferation, contact inhibition, anchorage-independent cell growth, and apoptosis.
Pawlak
G
G
Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, New York 11724, USA. pawlak@cshl.org
Helfman
D M
DM
D000199:Actins / Q000502:physiology; D000818:Animals; D017209:Apoptosis; D002448:Cell Adhesion; D002471:Cell Transformation, Neoplastic / Q000378:metabolism* / Q000473:pathology; D003599:Cytoskeleton / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction
D000199:Actins; D020558:GTP Phosphohydrolases