Separation of nicotine metabolites by capillary zone electrophoresis and capillary zone electrophoresis/mass spectrometry.
The use of capillary zone electrophoresis (CZE) and capillary zone electrophoresis/mass spectrometry (CZE/MS) has been demonstrated, in principle, for the separation of nicotine and nicotine metabolites. The buffer system developed for separation and detection by CZE/UV was modified for use in CZE/MS analysis. Several of the metabolites are isobaric and tandem mass spectrometric (MS/MS) techniques have been used to differentiate such analytes.
Palmer
M E
ME
Division of Chemistry, Sheffield Hallam University, Howard St., Sheffield S1 1WB, UK.
Smith
R F
RF
Chambers
K
K
Tetler
L W
LW
D019075:Electrophoresis, Capillary / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D009538:Nicotine / Q000032:analysis* / Q000378:metabolism
D009538:Nicotine