Lowering the extracellular potassium concentration elicits epileptic activity in neocortical tissue of epileptic patients.
The increase in the extracellular potassium concentration ([K(+)](o)) is a well-established model of epilepsy (the so-called high potassium model). Therefore, it is generally accepted that for the prevention of abnormal excitability and seizure generation, increases of [K(+)](o) must be avoided. In this paper, however, we show that on the contrary, a reduction of [K(+)](o) also elicits epileptic activity in brain slices of man.
Gorji
A
A
Institut für Physiologie, Westfälische Wilhelms-University Münster, Robert-Koch-Strasse 27a, D-48149 Münster, Germany. gorjial@uni-muenster.de
Köhling
R
R
Straub
H
H
Höhling
J M
JM
Madeja
M
M
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D017029:Epilepsy, Complex Partial / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D008297:Male; D008875:Middle Aged; D019579:Neocortex / Q000378:metabolism / Q000503:physiopathology*; D011188:Potassium / Q000494:pharmacology*
D011188:Potassium