Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol.
Dietary fibers are widely used in hypoglycaemic, hypolipidemic, slimming diets. It is probable that their ingestion coincides with the oral administration of drugs and a modification of their pharmacokinetics can appear. In the present study, the influence of two soluble fibers (guar gum and psyllium) was evaluated on the pharmacokinetics of ethinyloestradiol (EE) when they were administered together to female rabbits via the oral route. Three groups of rabbits were used. All animals received 1 mg/kg of EE; this compound was administered alone in the control group and with 3.5 g of guar gum or psyllium in the other two groups. When guar gum was administered, there was a decrease in the extent of EE absorbed, but no change was observed in the rate of absorption. When psyllium was administered, the extent of EE absorbed increased slightly and the rate of absorption was slower.
García
J J
JJ
Departamento de Farmacología, Toxicología y Enfermería. Universidad de León, León, Spain.
Fernández
N
N
Diez
M J
MJ
Sahagún
A
A
González
A
A
Alonso
M L
ML
Prieto
C
C
Calle
A P
AP
Sierra
M
M
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D004043:Dietary Fiber / Q000494:pharmacology*; D045166:Estradiol Congeners / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D005685:Galactans / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects*; D008351:Mannans / Q000494:pharmacology; D053149:Plant Gums; D011620:Psyllium / Q000494:pharmacology; D011817:Rabbits
D004043:Dietary Fiber; D045166:Estradiol Congeners; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; D004997:Ethinyl Estradiol; D011620:Psyllium; C007894:guar gum