The human interferon alpha species and receptors.
Interferon (IFN) was approved by the U.S. Food and Drug Administration on June 5, 1986. As the first biotherapeutic approved, IFN-alpha paved the way for development of many other cytokines and growth factors. Nevertheless, we have just touched the surface of understanding the multitude of human IFNs. This paper reviews the history of the purification of human leukocyte IFN and key aspects of our current state of knowledge of human interferon alpha genes, proteins, and receptors.
Pestka
S
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Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854-5635, USA. Pestka@Genetics.Rugtgers.edu
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007370:Interferon Type I / Q000235:genetics / Q000302:isolation & purification; D016898:Interferon-alpha / Q000235:genetics / Q000302:isolation & purification* / Q000494:pharmacology; D008954:Models, Biological; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000235:genetics / Q000302:isolation & purification*; D011994:Recombinant Proteins; D020539:Sequence Analysis, Protein; D015398:Signal Transduction; D000096743:Interferon gamma Receptor
D007370:Interferon Type I; D016898:Interferon-alpha; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D000096743:Interferon gamma Receptor