title: JC virus as a marker of human migration to the Americas.
abstract: JC virus is a ubiquitous human polyomavirus present in populations worldwide. Seven genotypes differing in DNA sequence by approximately 1-3% characterize three Old World population groups (African, European and Asian) as well as Oceania. It is possible to follow Old World populations into the New World by the JC virus genotypes they carried. The first population to settle in the Americas, the Native Americans, brought with them type 2A from northeast Asia. European settlers arriving after Columbus carried primarily type 1 and type 4. Africans brought by the slave trade carried type 3 and type 6.
authors.affiliation: Neurotoxicology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. stonerg@ninds.nih.gov
authors.forename: G L
authors.initials: GL
authors.lastname: Stoner
authors.forename: D V
authors.initials: DV
authors.lastname: Jobes
authors.forename: M
authors.initials: M
authors.lastname: Fernandez Cobo
authors.forename: H T
authors.initials: HT
authors.lastname: Agostini
authors.forename: S C
authors.initials: SC
authors.lastname: Chima
authors.forename: C F
authors.initials: CF
authors.lastname: Ryschkewitsch
mesh_terms: D000569:Americas / Q000453:epidemiology; D015415:Biomarkers; D004641:Emigration and Immigration; D005828:Genetics, Population; D006801:Humans; D007577:JC Virus / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D027601:Polyomavirus Infections / Q000453:epidemiology / Q000821:virology*
chemical_list: D015415:Biomarkers