title: Screening the Brazilian flora for antihypertensive plant species for in vitro angiotensin-I-converting enzyme inhibiting activity.
abstract: The evaluation of several antihypertensive activity of Brazilian plant species was performed using in vitro inhibition of the angiotensin I-converting enzyme (ACE). Nineteen species belonging to 13 families were investigated. Plants were selected based on their use as diuretics and on a chemosystematic consideration. Extracts of the following species presented the highest ACE inhibition rate, at concentrations of 0.33 mg/ml: Ouratea semiserrata (Mart. & Nees) Engl. stems (68%), Cuphea cartagenesis (Jacq.) Macbride leaves (50%) and Mansoa hirsuta DC. leaves (54%). Some hypotheses about the nature of the compounds that may be responsible for the activity of these species are discussed in the paper.
authors.affiliation: Faculdade de Farmácia, UFMG, Belo Horizonte, Brazil. fernao@dedalus.lcc.ufmg.br
authors.forename: F
authors.initials: F
authors.lastname: Castro Braga
authors.forename: H
authors.initials: H
authors.lastname: Wagner
authors.forename: J A
authors.initials: JA
authors.lastname: Lombardi
authors.forename: A B
authors.initials: AB
authors.lastname: de Oliveira
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry*; D000959:Antihypertensive Agents / Q000737:chemistry*; D001938:Brazil; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D010936:Plant Extracts