title: Effects of aging and blood pressure on the structure of the thoracic aorta in SAM mice: a model of age-associated degenerative vascular changes.
abstract: The effects of aging and blood pressure on the structural alterations of the thoracic aorta were examined using male, accelerated senescence-prone, short-lived SAMP11 mice or accelerated senescence-resistant, long-lived SAMR1 mice. The aortic wall thickness increased significantly by 34% in SAMR1 and by 62% in SAMP11 with advanced age. We observed branching, breakage and disorganization of the elastic lamellae, an increase in thin collagen fibrils between the medial smooth muscle cells and hypertrophy but a significant decrease in the number of medial smooth muscle cells with aging in both strains. These alterations observed in SAMP11 occurred earlier and were more exaggerated with advanced age than in SAMR1. The aortic lumen dilated gradually in SAMR1, but narrowed significantly in SAMP11 with aging. The systolic blood pressure did not differ significantly among SAMP11s aged 3-9months, or among all ages of SAMR1. However, it was elevated in SAMP11 at the terminal stage of their life. Our results suggest that the aorta in SAMR1 might reflect the physiological process of aging, whereas SAMP11 showed earlier changes due to the senescence acceleration of the vascular cells, which were exaggerated by the elevated blood pressure.
authors.affiliation: Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Sakyo-ku, 606-8507, Kyoto, Japan.
authors.forename: B H
authors.initials: BH
authors.lastname: Zhu
authors.forename: M
authors.initials: M
authors.lastname: Ueno
authors.forename: T
authors.initials: T
authors.lastname: Matsushita
authors.forename: H
authors.initials: H
authors.lastname: Fujisawa
authors.forename: N
authors.initials: N
authors.lastname: Seriu
authors.forename: T
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Hosokawa
mesh_terms: D000375:Aging / Q000502:physiology*; D019588:Aging, Premature / Q000473:pathology* / Q000503:physiopathology*; D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology*; D001794:Blood Pressure / Q000502:physiology*; D001835:Body Weight; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014652:Vascular Diseases / Q000473:pathology