Different effects of yohimbine and idazoxan in the light-dark choice procedure.
In a light-dark choice situation, the alpha(2) adrenoceptor antagonists yohimbine and idazoxan had different effects: idazoxan decreased time spent in the fit box, but yohimbine did not. The effects of idazoxan were not blocked by the alpha(2) adrenoceptor agonist clonidine. The benzodiazepine receptor antagonist Ro 15-1788 itself decreased time spent in the lit box, but in the presence of Ro 15-1788, idazoxan did not cause any further reduction.
Chapouthier
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Génétique, Neurogénétique et Comportement, URA 1294, CNRS, UFR Biomédicalé Paris V, 45, Rue des Saints Pères, 75270 Paris Cedex 06, France.
Jacquot
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Venault
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Sara
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