A high-density genetic map of the chromosome 13q14 atopy locus.
Atopy describes a syndrome of immunoglobulin E (IgE)-mediated allergy that underlies asthma and infantile eczema. We have previously identified a locus on chromosome 13q14 that is linked to atopy and to the total serum immunoglobulin A concentration. We have therefore made a saturation genetic map of the region by typing 59 polymorphic microsatellite loci on chromosome 13q. Multipoint linkage analysis identified a 1-LOD support unit for the location of the atopy locus with a 7.5-cM region flanked by the loci D13S328 and D13S1269. The peak of linkage was at locus D13S161 with a nonparametric -log of P score of approximately 4.5. Parent of origin effects were present, with linkage primarily observed to paternally derived alleles. The genetic map of this region provides a basis for the effective identification of the chromosome 13 atopy gene.
Bhattacharyya
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Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, United Kingdom.
Leaves
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Wiltshire
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Cox
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Cookson
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D000293:Adolescent; D000328:Adult; D002648:Child; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D008875:Middle Aged
D007070:Immunoglobulin A