title: [The study of biocompatibility of titanium in middle ear cave of guinea-pig].
abstract: In order to supply full objective basis about tympanoplasty with titanium, 30 middle ear caves of guinea-pigs were implanted titanium ring in accordance with different time groups. Both before and after titanium ring were implanted, the guinea-pigs were detected in biochemical criterion of blood, titanium content of the hair, the changing of auditory threshold, tissue structural of middle ear and inner ear by energy spectrometry, electro-physiology, microscopy and scanning electron microscopy. The results showed that function of hepatorenal and titanium content of hair haven't significant change between pre- and postimplantation of titanium ring. Only 10 days group, it appeared the rising of auditory threshold and inverting of cilia by ABR and scanning electron microscopy. In 10 days and 1 month groups, there were blood stain and inflammatory cells under mucosa. The results suggested that titanium is good biocompatibility and no toxic for organism and mucosa.
authors.affiliation: ENT Department of Nanfang Hospital, 1st Military Medical University, Guangzhuo 510515.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Zhong
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D007758:Ear, Inner / Q000648:ultrastructure; D004432:Ear, Middle / Q000648:ultrastructure*; D016057:Evoked Potentials, Auditory, Brain Stem; D006168:Guinea Pigs; D006197:Hair / Q000378:metabolism; D009998:Ossicular Prosthesis; D014025:Titanium / Q000378:metabolism / Q000633:toxicity*
chemical_list: D001672:Biocompatible Materials; D014025:Titanium