title: Differential filtering of two presynaptic depression mechanisms.
abstract: The filtering of input signals carried out at synapses is key to the information processing performed by networks of neurons. Two forms of presynaptic depression, vesicle depletion and G-protein inhibition of Ca2+ channels, can play important roles in the presynaptic processing of information. Using computational models, we demonstrate that these two forms of depression filter information in very different ways. G-protein inhibition acts as a high-pass filter, preferentially transmitting high-frequency input signals to the postsynaptic cell, while vesicle depletion acts as a low-pass filter. We examine how these forms of depression separately and together affect the steady-state postsynaptic responses to trains of stimuli over a range of frequencies. Finally, we demonstrate how differential filtering permits the multiplexing of information within a single impulse train.
authors.affiliation: Institute of Molecular Biophysics, Florida State University, Tallahassee 32306, USA.
authors.forename: R
authors.initials: R
authors.lastname: Bertram
mesh_terms: D015220:Calcium Channels / Q000378:metabolism*; D004553:Electric Conductivity; D004594:Electrophysiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D008959:Models, Neurological; D017729:Presynaptic Terminals / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D013572:Synaptic Vesicles / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D019204:GTP-Binding Proteins