Plasma concentrations of interleukin-1beta, interleukin-6, soluble interleukin-2 receptor and tumor necrosis factor alpha of depressed patients in Japan.
There are a number of investigations which indicate the important relationship between depression and cytokines. In this study, we investigated plasma interleukin (IL)-1beta, IL-6, soluble IL-2 receptor (sIL-2R) and tumor necrosis factor (TNF)-alpha of depressed patients whose clinical evaluation was performed by the Hamilton Rating Scale for Depression (HAM-D) and the Profile of Mood States (POMS). They were compared with those of the control subjects, and before and after treatment with antidepressants. Before the treatment, plasma IL-1beta, IL-6, sIL-2R and TNF-alpha of the patients were not significantly different from those of the control subjects. sIL-2R was positively correlated with the POMS-tension-anxiety subscale and tended to have a positive correlation with HAM-D. After pharmacotherapy, TNF-alpha levels of the depressed patients increased, without any relationship between the change in the HAM-D or the POMS and the change in TNF-alpha. These results suggest that the plasma sIL-2R concentration is associated with mood state, and that the plasma TNF-alpha concentration is increased after pharmacotherapy in Japanese depressed patients.
Kagaya
A
A
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, 123 Kasumi, Minami-ku, Hiroshima,734-8551, Japan. kagaya@hiroshima-u.ac.jp
Kugaya
A
A
Takebayashi
M
M
Fukue-Saeki
M
M
Saeki
T
T
Yamawaki
S
S
Uchitomi
Y
Y
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007564:Japan; D008297:Male; D011569:Psychiatric Status Rating Scales; D015375:Receptors, Interleukin-2 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000928:Antidepressive Agents; D007375:Interleukin-1; D015850:Interleukin-6; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha