Effects of small dose of brotizolam on P300.
Nine healthy men (mean age, 22.2 years) participated in two experimental sessions cross-overed randomly in a double blind manner; one with a placebo and the other with 0.125 mg of brotizolam (BTZ) administered in the morning. Resting electroencephalogram and event-related potential under oddball paradigm was recorded before and 1, 2, 4, 6 and 8 h after the administration. Mean 30-msec bin amplitude from 240 msec to 450 msec after the stimulus was compared between placebo and drug sessions in order to observe P300. Brotizolam reduced the amplitude of P300 at 6 h after administration. It was noted that the effects of BTZ were most marked at Fz.
Hayakawa
T
T
Department of Psychiatry, Kohnodai Hospital, National Center of Neurology and Psychiatry, Ichikawa, Japan. hykw@xa2.so-net.ne.jp
Uchiyama
M
M
Enomoto
T
T
Nakajima
T
T
Kim
K
K
Shibui
K
K
Kudo
Y
Y
Ozaki
S
S
Nakajima
T
T
Suzuki
H
H
Urata
J
J
Okawa
M
M
D000328:Adult; D001381:Azepines / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D018913:Event-Related Potentials, P300 / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D014229:Triazolam / Q000494:pharmacology
D001381:Azepines; D006993:Hypnotics and Sedatives; D014229:Triazolam; C020960:brotizolam