title: Role of Complement and Antibodies in the Control and Facilitation of HIV Disease.
abstract: In humans the HIV infection results in a chronic disease with a permanent fight between factors controlling HIV and the escape of the virus. Fromthese control mechanisms the present review summarizes the role betwen complement and autoantibodies; the competition of complement and anti-HIV antibodies for binding sites, the role of mannan-binding lectin in the susceptibility to and in the survival after HIV infection, the contribution of complement-dependent enhancing type antibodies to the clinical progression of HIV disease as well as the changing pattern of some autoantibodies (mimicking MHC class II molecules, anti-heat shock protein 60 antibodies and anti-C1q antibodies) which were found to correlate to immunological and clinical parameters.
authors.affiliation: Semmelweis University of Medicine, 3rd Department of Medicine, Budapest, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Prohászka
authors.forename: Ferenc D
authors.initials: FD
authors.lastname: Tóth
authors.forename: Dénes
authors.initials: D
authors.lastname: Bánhegyi
authors.forename: George
authors.initials: G
authors.lastname: Füst