title: Use of dermal-like tissue in the management of chronic and acute full-thickness cutaneous wounds.
abstract: This paper presents a dermal replacement technique for cutaneous wounds of diverse origin. An autologous tissue-engineered dermal-like structure was implanted in one patient with an acute surgical excision of a nevus and in another patient with a chronic post-traumatic ulcer. The dermal constructs were well integrated with the wound area, and, at 3 weeks, an epidermal covering was implanted. In both cases, 3 to 8 weeks after autografting, good integration of the transplanted epidermis with the surrounding native skin and a good take over the dermal-like tissue occurred. The use of this technology, despite its high cost, is increasing. Clinicians choose it because it helps heal critical wounds for which current therapies have failed.
authors.affiliation: Institute of Histology and Embryology, Faculty of Medicine, University of Padova, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Brun
authors.forename: F
authors.initials: F
authors.lastname: Grosso
authors.forename: G
authors.initials: G
authors.lastname: Galassi
authors.forename: M
authors.initials: M
authors.lastname: Radice
authors.forename: C
authors.initials: C
authors.lastname: Tonello
authors.forename: R
authors.initials: R
authors.lastname: Cortivo
authors.forename: G
authors.initials: G
authors.lastname: Abatangelo
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002908:Chronic Disease; D005347:Fibroblasts / Q000166:cytology / Q000637:transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000601:surgery*; D016038:Skin Transplantation / Q000379:methods*; D014947:Wounds and Injuries / Q000601:surgery*