title: Age-related changes in cortical and trabecular bone mineral status. A quantitative CT study in lumbar vertebrae.
abstract: OBJECTIVE
  To investigate the age and sex dependence of the bone mineral status of human lumbar vertebrae with special regard to differences between cortical and trabecular bone.
  
  
  METHODS
  The study group comprised 125 normal Japanese healthy volunteers (54 males and 71 females), and was subdivided into adult male and female groups (subjects younger than 40 years), intermediate male and female groups (ages ranging between 41 and 64 years) and old male and female groups (subjects older than 65 years). The cortical bone mineral status was estimated using a single-energy quantitative CT (SE-QCT) technique, whereas trabecular bone mineral density (BMD) was estimated using a dual-energy (DE-QCT) technique.
  
  
  RESULTS
  A considerable gender difference in the age-related cortical bone status was found. There was a significant reduction of the mean values of the cortical volume and BMD in the old female group compared with those obtained in the old male group.
  
  
  CONCLUSIONS
  The results suggest that in men, cortical and trabecular bone volume decrease very little with age. In women, cortical volume and BMD and trabecular BMD decrease with age while trabecular bone volume does not. The study showed that all variables had higher values in men than in women and that the difference increased with age.
authors.affiliation: Department of Radiology, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tanno
authors.forename: T
authors.initials: T
authors.lastname: Horiuchi
authors.forename: I
authors.initials: I
authors.lastname: Nakajima
authors.forename: S
authors.initials: S
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
authors.forename: H
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D007564:Japan; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000254:growth & development / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed / Q000379:methods*