Reporter resins for solid-phase chemistry.
[reaction: see text] An analytical construct resin, designed to aid the analysis of solid-phase chemistry, has been mixed in a small proportion with a conventional resin. The analytical construct ("reporter resin") contains two orthogonal linkers that allow cleavage of either the synthetic intermediates (at linker 2) or their analytically enhanced derivatives (at linker 1). The convenient and rapid monitoring of each step in the syntheses of representative library compounds was possible using small resin aliquots.
Congreve
M S
MS
Glaxo Wellcome Cambridge Chemistry Laboratory, University Chemical Laboratories, Lensfield Road, Cambridge, CB2 1EW, UK. mc0067@glaxowellcome.co.uk
Ladlow
M
M
Marshall
P
P
Parr
N
N
Scicinski
J J
JJ
Sheppard
T
T
Vickerstaffe
E
E
Carr
R A
RA
D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D012116:Resins, Plant / Q000138:chemical synthesis* / Q000737:chemistry
D012116:Resins, Plant