[76Br]Bromodeoxyuridine PET in tumor-bearing animals.
5-bromodeoxyuridine (BUdR) provides in vitro measures of tumor cell proliferation. We used positron emission tomography to study tissue and plasma kinetics of [76Br]BUdR in tumor-bearing animals. In order to account for the slow washout of the major plasma metabolite, [76Br]bromide, a mathematical correction for the distribution volume of [76Br]bromide was applied. However, following correction specific tumor tracer retention was low or even zero and did not correlate with independent measures of proliferation. The kinetic characteristics of [76Br]BUdR make this tracer unsuitable for proliferation imaging.
Gardelle
O
O
Section of Diagnostic Imaging, Veterinary School, University of Zurich, 8057, Zürich, Switzerland.
Roelcke
U
U
Vontobel
P
P
Crompton
N E
NE
Guenther
I
I
Bläuenstein
P
P
Schubiger
A P
AP
Blattmann
H
H
Ryser
J E
JE
Leenders
K L
KL
Kaser-Hotz
B
B
D000818:Animals; D001967:Bromine Radioisotopes / Q000097:blood; D001973:Bromodeoxyuridine / Q000097:blood / Q000493:pharmacokinetics*; D002415:Cats; D004285:Dogs; D005260:Female; D005434:Flow Cytometry; D006207:Half-Life; D008297:Male; D008433:Mathematics; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D001967:Bromine Radioisotopes; D011838:Radiation-Sensitizing Agents; D001973:Bromodeoxyuridine