Gene targeting in hemostasis. tissue factor.
Tissue factor (TF) is the primary cellular initiator of blood coagulation. At sites of vascular injury, formation of a TF:FVIIa complex leads to the generation of FXa, thrombin and the deposition of fibrin to limit hemorrhage. In contrast to its beneficial role in hemostasis, TF initiates life-threatening intravascular thrombosis in sepsis, atherosclerosis and cancer. More recently, TF has been proposed to play a role in other biological processes, including tumor-associated angiogenesis, metastasis and inflammation. Indeed, gene targeting of TF resulted in embryonic lethality, which appeared to be due to a defect in the yolk sac vasculature.
Mackman
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The Scripps Research Institute, Depts. of Immunology & Vascular Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. nmackman@scripps.edu
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000196:embryology / Q000235:genetics; D020868:Gene Silencing; D018390:Gene Targeting; D006487:Hemostasis / Q000235:genetics*; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013917:Thrombin / Q000378:metabolism; D013925:Thromboplastin / Q000737:chemistry / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism; D015017:Yolk Sac / Q000378:metabolism
D013925:Thromboplastin; D013917:Thrombin