The use of neural transplantation for suppression of seizure activity in genetically epilepsy-prone rats.
The possibility of correcting seizure activity with neural transplantation was studied in Wistar rats with audiogenic seizures and in Krushinskii-Molodkina rats with high level of audiogenic seizures. In Wistar rats seizures were absent during 24 weeks after combined bilateral transplantation of striatal and cerebellar tissue from newborn rats into the parietal cortex. The same transplantation performed in Krushinskii--Molodkina rats increased the latency of audiogenic seizures. In some rats the intensity of seizures decreased, but they did not completely disappeared. Suppression of seizure activity in Krushinskii-Molodkina rats was observed after transplantation of striatal and cerebellar tissue simultaneously into the parietal cortex and inferior colliculi.
Ermakova
I V
IV
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Kuznetsova
G D
GD
Loseva
E V
EV
Sidorenkov
A E
AE
Ioffe
M E
ME
D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D004827:Epilepsy / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D009474:Neurons / Q000473:pathology / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*