Do children with Hodgkin's disease have a better prognosis than adults? Application of a generalised linear model to a systematic review of published results.
This investigation aimed to compare survival rates in paediatric and adult Hodgkin's disease using published results. When comparing results obtained in different studies and institutions it is important to explain, estimate and allow for heterogeneity between studies. This was attempted though systematic inclusion of a large number of published results, through modelling the influence of covariates on survival using a generalised linear model, and by estimation of both the sampling errors in the extracted survival rates and the heterogeneity between studies. A significant superiority of treatment results in paediatric institutions compared with adult institutions was demonstrated, allowing for differences in patient and treatment characteristics.
Franklin
J
J
Biometrie, Zentrum für Innere Medizin, Universität Köln, Herder Str. 52-54, 50931 Köln, Germany.
D000328:Adult; D002648:Child; D015331:Cohort Studies; D006689:Hodgkin Disease / Q000401:mortality* / Q000628:therapy; D006801:Humans; D016014:Linear Models; D011379:Prognosis; D016019:Survival Analysis