title: Apolipoprotein D expression in endometrial carcinomas.
abstract: BACKGROUND
  Apolipoprotein D is a protein component of the human plasma lipid transport system but is also associated with a more favorable prognosis in breast cancer and ovarian cancer women. This study was undertaken to examine the tumoral expression of apolipoprotein D in endometrial cancer and to analyze the possible correlation with tumor and patients characteristics as well as androgen receptors and its prognostic significance.
  
  
  METHODS
  Immunohistochemical evaluation was used to examine apolipoprotein D expression in paraffin blocks from 58 endometrial carcinomas.
  
  
  RESULTS
  A total of twenty (34%) tumors stained positively. Staining was localized in tumor cells. No significant correlation was found between apo D expression and patients or tumor characteristics and androgen receptor status. In addition, apolipoprotein D expression was not associated with patient prognosis.
  
  
  CONCLUSIONS
  Apolipoprotein D is expressed by a significant percentage of endometrial carcinomas without apparent association with other clinicopathologic parameters or with outcome of patients.
authors.affiliation: Department of Gynecology, Hospital de Jove, Gijón, Asturias, Spain.
authors.forename: J V
authors.initials: JV
authors.lastname: Rojo
authors.forename: L O
authors.initials: LO
authors.lastname: González
authors.forename: M L
authors.initials: ML
authors.lastname: Lamelas
authors.forename: A
authors.initials: A
authors.lastname: Merino
authors.forename: F
authors.initials: F
authors.lastname: Vizoso
mesh_terms: D001053:Apolipoproteins / Q000378:metabolism*; D053399:Apolipoproteins D; D014408:Biomarkers, Tumor / Q000032:analysis*; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000401:mortality; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D011379:Prognosis; D011944:Receptors, Androgen / Q000378:metabolism
chemical_list: D001053:Apolipoproteins; D053399:Apolipoproteins D; D014408:Biomarkers, Tumor; D011944:Receptors, Androgen