The molecular epidemiology of HIV type 1 of men in Mexico.
Genotypic characteristics of human immunodeficiency virus type 1 (HIV-1) in Mexico were investigated in a multicenter study that involved centers in five geographic regions of the country. Study samples (n = 65) collected from male patients in 1998-1999 were sequenced within the C2-V5 region of the gp120 env gene. Phylogenetic analysis revealed that subtype B predominates in Mexico. The level of interpatient nucleotide diversity (mean value of 8.9%) was congruent with multiple introductions of the virus and the "aging" epidemic in Mexico. One-third of samples (30.8% of cases) showed polymorphism within the crown of the V3 loop demonstrating non-GPGR motifs. Two new motifs in the V3 loop crown - HPGG and GPEG - were observed. The evolution of the AIDS epidemic in Mexico should be closely monitored since non-B HIV-1 subtypes might be introduced. The nucleotide sequences were deposited in the GenBank under accession numbers AF200855-AF200869, AF200871-AF200892, and AF200894-AF200921.
Rivera-Morales
L G
LG
Laboratorio de Inmunología y Virología de la Facultad de Ciencias Biológicas de la Universidad Autónoma de Nuevo León (UNAL), Mexico.
Novitsky
V A
VA
Trujillo
J R
JR
Lavalle-Montalvo
C
C
Cano-Dominguez
C
C
Ramos-Jimenez
J
J
Jimenez-Rios
E
E
Flores-Flores
L
L
Lopez-Guillen
P
P
Gilbert
P
P
Vannberg
F
F
Tamez-Guerra
R
R
Rodriguez-Padilla
C
C
Essex
M
M
D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D008297:Male; D008800:Mexico / Q000453:epidemiology; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA
D015699:HIV Envelope Protein gp120