Regulation of matrix metalloproteinase expression in endothelial cells by heat-inactivated Streptococcus pneumoniae.
Matrix metalloproteinases (MMPs) may contribute to an impaired endothelial layer in several diseases. We examined the effect of heat-inactivated Streptococcus pneumoniae R6 on MMP-2 and MMP-9 release by cultured aortic and brain capillary endothelial cells. Treatment with heat-inactivated S. pneumoniae caused an increased release of MMP-2 by both cell types.
Michel
U
U
Neurobiologisches Labor, Neurologische und Psychiatrische Klinik, 37075 Göttingen, Germany. umichel@gwdg.de
Zobotke
R
R
Mäder
M
M
Nau
R
R
D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology*; D015971:Gene Expression Regulation, Enzymologic; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis; D020782:Matrix Metalloproteinases / Q000096:biosynthesis*; D013296:Streptococcus pneumoniae / Q000276:immunology / Q000472:pathogenicity*; D013552:Swine; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D020782:Matrix Metalloproteinases; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D013755:Tetradecanoylphorbol Acetate