Role of granuloma in the immunopathogenesis of Crohn's disease.
Inflammatory bowel diseases (ulcerative colitis and Crohn's disease) are chronic long-lasting inflammatory diseases with yet unknown etiology. Recent advancement revealed that both diseases are associated with genetic predisposition and environmental factors such as luminal microorganisms and antigens. Crohn's disease is associated with histopathologic features such as granuloma formation and longitudinal ulceration. In this article we describe the role of granuloma in the immunopathogenesis of Crohn's disease. Granuloma of Crohn's disease may play crucial roles as antigen-presenting cites to memory type T cells, which leads to activation and proliferation of T cells. Antigens presented at granuloma may be closely related to the disease.
Matsumoto
T
T
Department of Internal Medicine III, Osaka City University Medical School, Osaka, Japan. matsut@med.osaka-cu.ac.jp
Nakamura
S
S
Jin-No
Y
Y
Sawa
Y
Y
Hara
J
J
Oshitani
N
N
Arakawa
T
T
Otani
H
H
Nagura
H
H
D015703:Antigens, CD / Q000276:immunology; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D002455:Cell Division; D003424:Crohn Disease / Q000276:immunology* / Q000503:physiopathology*; D006099:Granuloma / Q000150:complications* / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000276:immunology; D012333:RNA, Messenger / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D008562:Membrane Glycoproteins; D012333:RNA, Messenger